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Sample records for kairomone induced life

  1. Fish kairomones induce spine elongation and reduce predation in marine crab larvae.

    Science.gov (United States)

    Charpentier, Corie L; Wright, Alexander J; Cohen, Jonathan H

    2017-08-01

    Specialized defense strategies are induced in zooplankton upon detection of predator chemical cues or kairomones. These defenses are well-described for freshwater zooplankters, with morphological defenses being particularly striking, but few studies have reported kairomone-induced morphological defenses in marine zooplankton. Here, we compare morphological responses to kairomones in the larvae of two marine crab species, estuarine mud crabs (Rhithropanopeus harrisii) and Asian shore crabs (Hemigrapsus sanguineus). When reared in the presence of fish kairomones, spine length increased by 2-3% in larval R. harrisii, while no morphological changes were identified in H. sanguineus. In subsequent feeding assays with a co-occurring fish predator (Atlantic silversides, Menidia menidia), consumption of R. harrisii was lower on larvae that had been reared with kairomones. In addition, we found that broods with smaller larvae are more likely to exhibit increases in spine length after kairomone exposure. Hence, the observed morphological response is likely influenced by larval size. © 2017 by the Ecological Society of America.

  2. Variation in copper effects on kairomone-mediated responses in Daphnia pulicaria.

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    DeMille, C M; Arnott, S E; Pyle, G G

    2016-04-01

    Chemical signals play an integral role in many predator-prey relationships but their effectiveness can be altered by environmental conditions. Prey species can detect predator kairomones, which induce anti-predator defenses. An example of this predator-prey relationship exists between Daphnia spp. and Chaoborus spp.; however, when living in water contaminated with low concentrations of copper (Cu) Daphnia can fail to respond to Chaoborus kairomone and, in turn, become more susceptible to predation. This has implications for Daphnia living in regions with Cu contamination, such as areas where mining activity has resulted in increased levels of metals in the surrounding lakes. We examined kairomone-mediated responses of multiple Daphnia pulicaria clones obtained from 8 lakes in Ontario, Canada, in the absence and presence of environmentally-relevant Cu concentrations. Life history traits and morphological anti-predator defenses were assessed using neonates collected from mothers that were exposed to kairomone and Cu treatments. We found that kairomone-mediated responses and Cu-tolerance varied among D. pulicaria clones. Clones exposed to kairomone, in the absence of Cu additions, had diverse responses, including larger neonates, delayed reproduction, or altered brood size relative to no-kairomone controls. These kairomone-induced responses act as antipredator defense strategies against Chaoborus by preventing predation or stabilizing population growth. When exposed to Cu, two clones were able to respond to kairomone, while four clones no longer induced a response to kairomone. This variation in non-lethal effects of Cu on aquatic organisms suggests that toxicity tests should incorporate multiple genotypes and include predator-prey interactions. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice

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    Lluís eFortes-Marco

    2015-10-01

    Full Text Available Chemosignals mediate both intra- and inter-specific communication in most mammals. Pheromones elicit stereotyped reactions in conspecifics, whereas kairomones provoke a reaction in an allospecific animal. For instance, predator kairomones elicit anticipated defensive responses in preys. The aim of this work was to test the behavioral responses of female mice to two chemosignals: 2-heptanone (2-HP, a putative alarm pheromone, and 2,4,5-trimethylthiazoline (TMT, a fox-derived putative kairomone, widely used to investigate fear and anxiety in rodents. The banana-like odorant isoamyl acetate (IA, unlikely to act as a chemosignal, served as a control odorant. We first presented increasing amounts of these odorants in consecutive days, in a test box in which mice could explore or avoid them. Female mice avoided the highest amounts of all three compounds, with TMT and IA eliciting avoidance at lower amounts (3.8 pmol and 0.35 μmol, respectively than 2-HP (35 μmol. All three compounds induced minimal effects in global locomotion and immobility in this set up. Further, mice detected 3.5 pmol of TMT and IA in a habituation-dishabituation test, so avoidance of IA started well beyond the detection threshold. Finally, both TMT and IA, but not 2-HP, induced conditioned place avoidance and increased immobility in the neutral compartment during a contextual memory test. These data suggest that intense odors can induce contextual learning irrespective of their putative biological significance. Our results support that synthetic predator-related compounds (like TMT or other intense odorants are useful to investigate the neurobiological basis of emotional behaviors in rodents. Since intense odorants unlikely to act as chemosignals can elicit similar behavioral reactions than chemosignals, we stress the importance of using behavioral measures in combination with other physiological (e.g. hormonal levels or neural measures (e.g. immediate early gene expression to

  4. Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice.

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    Fortes-Marco, Lluís; Lanuza, Enrique; Martínez-García, Fernando; Agustín-Pavón, Carmen

    2015-01-01

    Chemosignals mediate both intra- and inter-specific communication in most mammals. Pheromones elicit stereotyped reactions in conspecifics, whereas kairomones provoke a reaction in an allospecific animal. For instance, predator kairomones elicit anticipated defensive responses in preys. The aim of this work was to test the behavioral responses of female mice to two chemosignals: 2-heptanone (2-HP), a putative alarm pheromone, and 2,4,5-trimethylthiazoline (TMT), a fox-derived putative kairomone, widely used to investigate fear and anxiety in rodents. The banana-like odorant isoamyl acetate (IA), unlikely to act as a chemosignal, served as a control odorant. We first presented increasing amounts of these odorants in consecutive days, in a test box in which mice could explore or avoid them. Female mice avoided the highest amounts of all three compounds, with TMT and IA eliciting avoidance at lower amounts (3.8 pmol and 0.35 μmol, respectively) than 2-HP (35 μmol). All three compounds induced minimal effects in global locomotion and immobility in this set up. Further, mice detected 3.5 pmol of TMT and IA in a habituation-dishabituation test, so avoidance of IA started well beyond the detection threshold. Finally, both TMT and IA, but not 2-HP, induced conditioned place avoidance and increased immobility in the neutral compartment during a contextual memory test. These data suggest that intense odors can induce contextual learning irrespective of their putative biological significance. Our results support that synthetic predator-related compounds (like TMT) or other intense odorants are useful to investigate the neurobiological basis of emotional behaviors in rodents. Since intense odorants unlikely to act as chemosignals can elicit similar behavioral reactions than chemosignals, we stress the importance of using behavioral measures in combination with other physiological (e.g., hormonal levels) or neural measures (e.g., immediate early gene expression) to establish

  5. Interactions between predator kairomone and food level complicate the ecological interpretation of Daphnia laboratory results

    NARCIS (Netherlands)

    Weber, A.

    2001-01-01

    The effect of food concentration on the phenotypic response of life history traits to two predator kairomones war investigated in Daphnia. For the experiment, one clone of Daphnia galeata war used as the prey organism and solutions containing infochemicals (kairomones) of Chaoborus (phantom midge)

  6. Of pheromones and kairomones: what receptors mediate innate emotional responses?

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    Fortes-Marco, Lluis; Lanuza, Enrique; Martinez-Garcia, Fernando

    2013-09-01

    Some chemicals elicit innate emotionally laden behavioral responses. Pheromones mediate sexual attraction, parental care or agonistic confrontation, whereas predators' kairomones elicit defensive behaviors in their preys. This essay explores the hypothesis that the detection of these semiochemicals relies on highly specific olfactory and/or vomeronasal receptors. The V1R, V2R, and formyl-peptide vomeronasal receptors bind their ligands in highly specific and sensitive way, thus being good candidates for pheromone- or kairomone-detectors (e.g., secreted and excreted proteins, peptides and lipophilic volatiles). The olfactory epithelium also expresses specific receptors, for example trace amine-associated receptors (TAAR) and guanylyl cyclase receptors (GC-D and other types), some of which bind kairomones and putative pheromones. However, most of the olfactory neurons express canonical olfactory receptors (ORs) that bind many ligands with different affinity, being not suitable for mediating responses to pheromones and kairomones. In this respect, trimethylthiazoline (TMT) is considered a fox-derived kairomone for mice and rats, but it seems to be detected by canonical ORs. Therefore, we have reassessed the kairomonal nature of TMT by analyzing the behavioral responses of outbred (CD1) and inbred mice (C57BL/J6) to TMT. Our results confirm that both mouse strains avoid TMT, which increases immobility in C57BL/J6, but not CD1 mice. However, mice of both strains sniff at TMT throughout the test and show no trace of TMT-induced contextual conditioning (immobility or avoidance). This suggests that TMT is not a kairomone but, similar to a loud noise, in high concentrations it induces aversion and stress as unspecific responses to a strong olfactory stimulation. Copyright © 2013 Wiley Periodicals, Inc.

  7. Do bacteria, not fish, produce 'fish kairomone'?

    NARCIS (Netherlands)

    Ringelberg, J.; Van Gool, E.

    1998-01-01

    Fish-associated chemicals enhance phototactic downward swimming in Daphnia. If perch were treated with the antibiotic ampicillin, this enhancement was significantly decreased. Therefore, not fish, but bacteria associated with fish, seem to produce this kairomone. [KEYWORDS: Diel vertical migration;

  8. Gene up-regulation in response to predator kairomones in the water flea, Daphnia pulex

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    Okada Yasukazu

    2010-04-01

    Full Text Available Abstract Background Numerous cases of predator-induced polyphenisms, in which alternate phenotypes are produced in response to extrinsic stimuli, have been reported in aquatic taxa to date. The genus Daphnia (Branchiopoda, Cladocera provides a model experimental system for the study of the developmental mechanisms and evolutionary processes associated with predator-induced polyphenisms. In D. pulex, juveniles form neckteeth in response to predatory kairomones released by Chaoborus larvae (Insecta, Diptera. Results Previous studies suggest that the timing of the sensitivity to kairomones in D. pulex can generally be divided into the embryonic and postembryonic developmental periods. We therefore examined which of the genes in the embryonic and first-instar juvenile stages exhibit different expression levels in the presence or absence of predator kairomones. Employing a candidate gene approach and identifying differentially-expressed genes revealed that the morphogenetic factors, Hox3, extradenticle and escargot, were up-regulated by kairomones in the postembryonic stage and may potentially be responsible for defense morph formation. In addition, the juvenile hormone pathway genes, JHAMT and Met, and the insulin signaling pathway genes, InR and IRS-1, were up-regulated in the first-instar stage. It is well known that these hormonal pathways are involved in physiological regulation following morphogenesis in many insect species. During the embryonic stage when morphotypes were determined, one of the novel genes identified by differential display was up-regulated, suggesting that this gene may be related to morphotype determination. Biological functions of the up-regulated genes are discussed in the context of defense morph formation. Conclusions It is suggested that, following the reception of kairomone signals, the identified genes are involved in a series of defensive phenotypic alterations and the production of a defensive phenotype.

  9. Lack of spatial segregation in the representation of pheromones and kairomones in the mouse medial amygdala.

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    Vinicius Miessler de Andrade Carvalho

    2015-08-01

    Full Text Available The nervous system is organized to detect, internally represent and process sensory information to generate appropriate behaviors. Despite the crucial importance of odors that elicit instinctive behaviors, such as pheromones and kairomones, their neural representation remains little characterized in the mammalian brain. Here we used expression of the immediate early gene product c-Fos as a marker of neuronal activity to find that a wide range of pheromones and kairomones produces activation in the medial nucleus of the amygdala, a brain area anatomically connected with the olfactory sensory organs. We see that activity in this nucleus depends on vomeronasal organ input, and that distinct vomeronasal stimuli activate a dispersed ensemble of cells, without any apparent spatial segregation. This activity pattern does not reflect the chemical category of the stimuli, their valence or the induced behaviors. These findings will help build a complete understanding of how odor information is processed in the brain to generate instinctive behaviors.

  10. Chemical investigations of volatile kairomones produced by Hyphantria cunea (Drury), a host of the parasitoid Chouioia cunea Yang.

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    Zhu, G; Pan, L; Zhao, Y; Zhang, X; Wang, F; Yu, Y; Fan, W; Liu, Q; Zhang, S; Li, M

    2017-04-01

    In tritrophic 'plants-herbivores-natural enemies' systems, there are relatively few reports concerning the role(s) of kairomones in pupal parasitism. Chouioia cunea Yang (Hymenoptera: Eulophidae), an endoparasitic chalcid wasp, parasitizes pupae of the fall webworm (Hyphantria cunea Drury). The role of host-related kairomones was investigated using electroantennogram (EAG) and behavioral techniques. Chemicals from some host stages (pupae) and host by-products (frass), induced arrestment behavior of female parasitoids, while chemicals from prepupae, were inactive. Gas chromatography-mass spectrometry analysis of volatiles collected from pupae, frass and prepupae using solid-phase microextration revealed seven compounds with carbon chain lengths ranging from C4 to C20. All of the chemicals elicited significant EAG responses in C. cunea. Y-tube olfactometer bioassays demonstrated a significant positive response of mated female C. cunea to 1-dodecene. These data provide a better understanding of the host location mechanisms of pupal parasitoid.

  11. ß-Phellandrene: Kairomone for Pine Engraver, Ips pini (Say) (Coleoptera: Scolytidae)

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    Daniel R. Miller; John H. Borden

    1990-01-01

    The responses of Ips pini (Scolytidae) to multiple-funnel traps baited with the pheromone, ipsdienol, and various monoterpenes were determined in stands of lodgepole pine in southern and central British Columbia. Ips pini was attracted to both ipsdienol and ß-phellandrene, demonstrating that ß-phellandrene is a kairomone for this...

  12. Prey preference of the phytoseiid mite Typhlodromus pyri. 1. Response to volatile kairomones.

    NARCIS (Netherlands)

    Dicke, M.

    1988-01-01

    Using a Y-tube olfactometer, a study has been made of the response of females of the predatory miteTyphlodromus pyri Scheuten (Acarina: Phytoseiidae) to volatile kairomones of three prey species: the European red spider mite (Panonychus ulmi (Koch)), the two-spotted spider mite (Tetranychus urticae

  13. Kairomonal communication in mice is concentration-dependent with a proportional discrimination threshold [v2; ref status: indexed, http://f1000r.es/2h5

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    Anand Vasudevan

    2013-12-01

    Full Text Available Odors of predators are often co-opted by prey species to serve as warning signals. Perceptual properties of such kairomonal communication are under studied despite their common use in many mammals. We demonstrate that the kairomonal response in mice to rat odors varies monotonically with the volume of rat odor. Moreover, the ability of mice to differentiate between two strengths of rat odors is dependent on the ratio of the two concentrations. These results show that mice can compare kairomonal strength over a large range of values, and that kairomonal communication follows Weber’s law.

  14. Insecticide resistance may enhance the response to a host-plant volatile kairomone for the codling moth, Cydia pomonella (L.)

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    Sauphanor, Benoît; Franck, Pierre; Lasnier, Thérèse; Toubon, Jean-François; Beslay, Dominique; Boivin, Thomas; Bouvier, Jean-Charles; Renou, Michel

    2007-06-01

    The behavioral and electroantennographic responses of Cydia pomonella (L.) to the ripe pear volatile ethyl (2 E,4 Z)-2,4-decadienoate (Et- E, Z-DD), were compared in insecticide-susceptible and -resistant populations originating from southern France. A dose-response relationship to this kairomonal attractant was established for antennal activity and did not reveal differences between susceptible and resistant strains. Conversely, males of the laboratory strains expressing metabolic [cytochrome P450-dependent mixed-function oxidases (mfo)] or physiological (kdr-type mutation of the sodium-channel gene) resistance mechanisms exhibited a significantly higher response to Et- E, Z-DD than those of the susceptible strain in a wind tunnel experiment. No response of the females to this kairomone could be obtained in our wind-tunnel conditions. In apple orchards, mfo-resistant male moths were captured at significantly higher rates in kairomone-baited traps than in traps baited with the sex pheromone of C. pomonella. Such a differential phenomenon was not verified for the kdr-resistant insects, which exhibited a similar response to both the sex pheromone and the kairomonal attractant in apple orchards. Considering the widespread distribution of metabolic resistance in European populations of C. pomonella and the enhanced behavioral response to Et- E, Z-DD in resistant moths, the development of control measures based on this kairomonal compound would be of great interest for the management of insecticide resistance in this species.

  15. Isolation and identification of volatile kairomone that affects acarine predator-prey interactions: involvement of host plant in its production.

    NARCIS (Netherlands)

    Dicke, M.; Beek, van T.A.; Posthumus, M.A.; Dom, Ben N.; Bokhoven, van H.; Groot, de Ae.

    1990-01-01

    A volatile kairomone emitted from lima bean plants (Phaseolus lunatus) infested with the spider miteTetranychus urticae, was collected on Tenax-TA and analyzed with GC-MS. Two components were identified as the methylene monoterpene (3E)-4,8-dimethyl-1,3,7-nonatriene and the methylene sesquiterpene

  16. Inhibition of predator attraction to kairomones by non-host plant volatiles for herbivores: a bypass-trophic signal.

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    Qing-He Zhang

    2010-06-01

    Full Text Available Insect predators and parasitoids exploit attractive chemical signals from lower trophic levels as kairomones to locate their herbivore prey and hosts. We hypothesized that specific chemical cues from prey non-hosts and non-habitats, which are not part of the trophic chain, are also recognized by predators and would inhibit attraction to the host/prey kairomone signals. To test our hypothesis, we studied the olfactory physiology and behavior of a predaceous beetle, Thanasimus formicarius (L. (Coleoptera: Cleridae, in relation to specific angiosperm plant volatiles, which are non-host volatiles (NHV for its conifer-feeding bark beetle prey.Olfactory detection in the clerid was confirmed by gas chromatography coupled to electroantennographic detection (GC-EAD for a subset of NHV components. Among NHV, we identified two strongly antennally active molecules, 3-octanol and 1-octen-3-ol. We tested the potential inhibition of the combination of these two NHV on the walking and flight responses of the clerid to known kairomonal attractants such as synthetic mixtures of bark beetle (Ips spp. aggregation pheromone components (cis-verbenol, ipsdienol, and E-myrcenol combined with conifer (Picea and Pinus spp. monoterpenes (alpha-pinene, terpinolene, and Delta(3-carene. There was a strong inhibitory effect, both in the laboratory (effect size d = -3.2, walking bioassay and in the field (d = -1.0, flight trapping. This is the first report of combining antennal detection (GC-EAD and behavioral responses to identify semiochemical molecules that bypass the trophic system, signaling habitat information rather than food related information.Our results, along with recent reports on hymenopteran parasitoids and coleopteran predators, suggest that some NHV chemicals for herbivores are part of specific behavioral signals for the higher trophic level and not part of a background noise. Such bypass-trophic signals could be of general importance for third trophic level

  17. Radiation-induced life shortening. Annex K

    International Nuclear Information System (INIS)

    1982-01-01

    The purpose of this Annex is to review the cumulative evidence in the field of non-neoplastic long-term effects of whole-body irradiation. In particular, the existence and extent of life-span shortening in irradiated animals and man, and the relationships of life shortening to the physical and biological variables which may influence this effect of radiation are examined.

  18. Vitamin A deficiency modifies response of predatory mite Amblyseius potentillae to volatile kairomone of two-spotted spider mite, Tetranychus urticae.

    NARCIS (Netherlands)

    Dicke, M.; Sabelis, M.W.; Groeneveld, A.

    1986-01-01

    volatile kairomone of the two-spotted spider mite,Tetranychus urticae, elicits a searching response of the phytoseiid predatorAmblyseius potentillae, only when the predator is reared on a carotenoid-free diet. However, after addition of crystalline betta-carotene or vitamin A acetate to the

  19. Training for Translocation: Predator Conditioning Induces Behavioral Plasticity and Physiological Changes in Captive Eastern Hellbenders (Cryptobranchus alleganiensis alleganiensis (Cryptobranchidae, Amphibia

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    Erin K. Kenison

    2018-03-01

    Full Text Available Translocations are stressful, especially when captive animals are naïve to natural stimuli. Captive eastern hellbenders (Cryptobranchus alleganiensis alleganiensis identify predatory fish as threats, but may be more vulnerable to predation and stress because of inexperience with them. We investigated the use of predator conditioning to prepare hellbenders, behaviorally and physiologically, for the presence of a common predator, largemouth bass (Micropterus salmoides. We reared hellbenders for 30 d with and without continuous exposure to largemouth bass kairomones and heterospecific alarm cues and found conditioned hellbenders became less active compared to unconditioned individuals (p = 0.017. After conditioning, we exposed hellbenders to water, a low concentration of kairomones, or a high concentration of kairomones in a closed respirometer system. We measured activity within respirometer chambers and routine metabolic rate. We found unconditioned hellbenders exposed to low and high concentrations of kairomones were 41% and 119% more active than conditioned animals (p = 0.002 and p < 0.001. Moreover, conditioned individuals had on average 6.5% lower metabolic rates across all three kairomone concentrations compared to unconditioned individuals (p = 0.017. Our data suggest that predator conditioning induces behavioral avoidance tactics and physiological changes that could improve future translocation efforts for hellbenders and other imperiled species.

  20. Field and laboratory responses of adult Ixodes scapularis (Acari: Ixodidae) to kairomones produced by white-tailed deer.

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    Carroll, J F; Mills, G D; Schmidtmann, E T

    1996-07-01

    In a field test, adult blacklegged ticks, Ixodes scapularis Say, of both sexes exhibited an arrestant response to substances associated with external glands on the legs of white-tailed deer, Odocoileus virginianus (Zimmermann), their principal host. Substances rubbed from the pelage covering tarsal and interdigital glands were applied to artificial vantage points simulating vegetation on which I. scapularis adults wait for host contact. A combination of tarsal substances (applied to the apex of the simulated vantage point) and interdigital gland substances (applied to the horizontal base) elicited a greater response than either treatment alone. A minimal response was observed on untreated vantage points. In laboratory bioassays using glass tubing as vantage points, substances associated with preorbital glands of deer elicited a strong arrestant response among I. scapularis females, whereas samples rubbed from the forehead, back, and a nonglandular area on deer tarsi evoked weak arrestant responses. These results support the hypothesis that the kairomonal properties of host-generated residues, either in conjunction with or in lieu of the effects of carbon dioxide, help account for the prevalence of host-seeking ticks along animal trails.

  1. Early-life family structure and microbially induced cancer risk.

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    Blaser, Martin J; Nomura, Abraham; Lee, James; Stemmerman, Grant N; Perez-Perez, Guillermo I

    2007-01-01

    Cancer may follow exposure to an environmental agent after many decades. The bacterium Helicobacter pylori, known to be acquired early in life, increases risk for gastric adenocarcinoma, but other factors are also important. In this study, we considered whether early-life family structure affects the risk of later developing gastric cancer among H. pylori+ men. We examined a long-term cohort of Japanese-American men followed for 28 y, and performed a nested case-control study among those carrying H. pylori or the subset carrying the most virulent cagA+ H. pylori strains to address whether family structure predicted cancer development. We found that among the men who were H. pylori+ and/or cagA+ (it is possible to be cagA+ and H. pylori- if the H. pylori test is falsely negative), belonging to a large sibship or higher birth order was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. For those with cagA+ strains, the risk of developing gastric cancer was more than twice as high (odds ratio 2.2; 95% confidence interval 1.2-4.0) among those in a sibship of seven or more individuals than in a sibship of between one and three persons. These results provide evidence that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later, and these findings lead to new models to explain these interactions.

  2. A promising biotechnical approach to pest management of Diabrotica virgifera virgifera in Illinois maize fields under kairomonal shielding with the new MSD technique.

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    Hummel, H E; Shaw, J T; Hein, D F

    2005-01-01

    Environmentally compatible and sustainable plant protection requires novel approaches to pest management characterized by minimal emphasis on toxicants. Classical toxicants traditionally dominated economic entomology for half a century. But worldwide problems with environmental pollution and with increasing resistance levels in all major pesticide classes and in many key insect species including Diabrotica virgifera virgifera (D.v.v.) strongly advocate a rethinking and a change in management paradigms used. Soft, minimally invasive, biological, biotechnical and cultural approaches should replace hard pesticides which are in favor up to now. Fortunately, pheromones, kairomones, plant attractants, better traps, new plant varieties and cultural methods like crop rotation, in short more sophisticated methods are now available as pressure for finding and exploring novel strategies increases. Facing this situation, a new biotechnical approach of population reduction of D.v.v., called "MSD" technique, is introduced. MSD is characterized as an approach combining mass trapping, shielding and deflecting of adult insects along an invisible odor barrier of synthetic kairomone which diminishes the flux of insects across a high capacity trap line baited with kairomone, thus reducing both the population fluctuation and number and its reproductive success within the shielded area. In the case of D.v.v. in Zea mays fields, effects realized by the MSD technique have been measured simultaneously by a number of independent criteria during the summers of 2003 and 2004 at 2 different locations in Illinois maize fields of up to one half hectare size. Results observed are statistically significant and cannot be explained by mass trapping alone. There is also an additional shielding and deflection, in short "diversion" effect whose basic sensory and behavioral mechanisms call for future exploration.

  3. The scent of wolves: pyrazine analogs induce avoidance and vigilance behaviors in prey

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    Kazumi eOsada

    2015-10-01

    Full Text Available The common grey wolf (Canis lupus is an apex predator located at the top of the food chain in the Northern Hemisphere. It preys on rodents, rabbits, ungulates, and many other kinds of mammal. However, the behavioral evidence for, and the chemical basis of, the fear-inducing impact of wolf urine on prey are unclear. Recently, the pyrazine analogs 2, 6-dimethylpyrazine, 2, 3, 5-trimethylpyrazine and 3-ethyl-2, 5-dimethyl pyrazine were identified as kairomones in the urine of wolves. When mice were confronted with a mixture of purified pyrazine analogs, vigilance behaviors, including freezing and excitation of neurons at the accessory olfactory bulb, were markedly increased. Additionally, the odor of the pyrazine cocktail effectively suppressed the approach of deer to a feeding area, and for those close to the feeding area elicited fear-related behaviors such as the tail-flag, flight, and jump actions. In this review, we discuss the transfer of chemical information from wolf to prey through the novel kairomones identified in wolf urine and also compare the characteristics of wolf kairomones with other predator-produced kairomones that affect rodents.

  4. Early-life family structure and microbially induced cancer risk.

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    Martin J Blaser

    2007-01-01

    Full Text Available Cancer may follow exposure to an environmental agent after many decades. The bacterium Helicobacter pylori, known to be acquired early in life, increases risk for gastric adenocarcinoma, but other factors are also important. In this study, we considered whether early-life family structure affects the risk of later developing gastric cancer among H. pylori+ men.We examined a long-term cohort of Japanese-American men followed for 28 y, and performed a nested case-control study among those carrying H. pylori or the subset carrying the most virulent cagA+ H. pylori strains to address whether family structure predicted cancer development. We found that among the men who were H. pylori+ and/or cagA+ (it is possible to be cagA+ and H. pylori- if the H. pylori test is falsely negative, belonging to a large sibship or higher birth order was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. For those with cagA+ strains, the risk of developing gastric cancer was more than twice as high (odds ratio 2.2; 95% confidence interval 1.2-4.0 among those in a sibship of seven or more individuals than in a sibship of between one and three persons.These results provide evidence that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later, and these findings lead to new models to explain these interactions.

  5. Respuesta kairomonal de coleópteros asociados a Dendroctonus frontalis y dos especies de Ips (Coleoptera: Curculionidae en bosques de Chiapas, México Kairomonal response of coleopterans associated with Dendroctonus frontalis and two Ips species (Coleoptera: Curculionidae in forest of Chiapas, Mexico

    Directory of Open Access Journals (Sweden)

    Bernardo Domínguez-Sánchez

    2008-06-01

    Full Text Available Se evaluó la diversidad de escarabajos descortezadores y la respuesta diferencial de sus coleópteros asociados a feromonas comerciales de agregación, en bosques de pino del estado de Chiapas, México. Durante los meses de junio a octubre del 2006, se colocaron 40 trampas multiembudo tipo Lindgren cebadas con las feromonas racémicas frontalina, ipsenol e ipsdienol y un testigo (sin feromona. La captura fue más abundante para los escarabajos descortezadores Dendroctonus frontalis (Zimmermann con frontalina, y de Ips spp. con ipsenol e ipsdienol. Se registró respuesta kairomonal específica de los depredadores Temnochila chlorodia (Mannerheim, Enoclerus ablusus (Barr y Elacatis sp. hacia las feromonas de agregación. Tanto para descortezadores como para depredadores, las mayores abundancias fueron registradas durante el verano y a comienzos del otoño. Temmnochila chlorodia exhibió una atracción diferencial hacia los semioquímicos evaluados, mientras que E. ablusus, Elacatis sp. y Leptostylus sp. fueron atraídos principalmente por las feromonas ipsenol e ipsdienol. Además, por primera vez para México se determinó la respuesta kairomonal del fitófago Leptostylus sp. (Cerambycidae. Estos resultados indican que hay una comunicación intra e inter específica entre los escarabajos descortezadores y sus especies asociadas que promueven interacciones de competencia y depredación.We assessed the bark beetle diversity and the response of associated predators to aggregation pheromones in pine forests in Chiapas, Mexico. From June to October 2006, 40 Lindgren funnel traps were established with different baits that included frontalin, ipsenol and ipsdienol pheromones and a control (without pheromone. We registered the attractiveness of frontalin to the bark beetle Dendroctonus frontalis (Zimmermann, and ipsenol and ipsdienol to Ips spp. Kairomonal specific response of the predators Temnochila chlorodia (Mannerheim, Enoclerus ablusus (Barr and

  6. Using a kairomone-based attracting system to enhance biological control of mealybugs (Hemiptera: Pseudococcidae by Anagyrus sp. near pseudococci (Hymenoptera: Encyrtidae in Sicilian vineyards

    Directory of Open Access Journals (Sweden)

    Ramzi Mansour

    2010-11-01

    Full Text Available The “potato trap” technique was applied for the fi rst time in Italian (Sicily vineyards in an attempt to assess: a the impact of the kairomonal activity of the vine mealybug sex pheromone (S-(+-lavandulyl senecioate (LS on the parasitism of mealybugs by the encyrtid Anagyrus sp. near pseudococci, b the influence of two commonly used insecticides on the parasitization activity of A. sp. near pseudococci towards mealybugs, and c the efficiency of the release of A. sp. near pseudococci in enhancing parasitism rates of mealybugs. The number of captured A. sp. near pseudococci females in LS baited traps was significantly higher than that in unbaited traps. The minimal number of days for the first parasitoid emergence in LS baited traps was almost 3 days earlier, compared to unbaited control, suggesting a faster host detection by the encyrtid when LS is applied. These findings resulted in a significant increase in parasitism of mealybugs by A. sp. near pseudococci in LS baited traps relative to unbaited traps suggesting that the LS is used by the encyrtid as kairomone to ensure greater potential for host searching activity. Insecticide treatments significantly affected parasitization activity of A. sp. near pseudococci on mealybugs when compared to an untreated control with parasitoid release. The buprofezin, chlorpyriphos-methyl and untreated control with no parasitoid release treatments had statistically similar numbers of emerged parasitoids from exposed mealybugs. The obtained results provide evidence that, in the absence of conventional insecticides applications, the use of the LS could be a promising tool to improve and strengthen biological control of mealybugs by A. sp. near pseudococci within Sicilian vineyard conditions.

  7. Chemotherapy-induced peripheral neuropathy : Impact on quality of life

    NARCIS (Netherlands)

    Scheel, A.; Beijers, A.J.M.; Mols, F.; Faber, C.G.; Vreugdenhil, G.

    2014-01-01

    Peripheral neuropathy is a frequently occurring side-effect of chemotherapy as a cancer treatment. The incidence of chemotherapy-induced peripheral neuropathy (CIPN) is increasing as a consequence of better treatment of cancer becoming available and increasing use of chemotherapy, and because CIPN

  8. Radiation-induced life-shortening and premature aging

    International Nuclear Information System (INIS)

    Walburg, H.E. Jr.

    1975-01-01

    Data from a number of studies on irradiated laboratory animals showed that almost none of the characteristic lesions associated with senescence that were studied adequately reflects a radiation effect analogous to premature aging. In fact, most of the age-related changes showed no effect of radiation at all, and many of those that did (for example, graying of hair, sterility, cataract formation) did not appear to be due to similar mechanisms. It is concluded that, in the light of more recent information, the hypothesis of radiation-induced premature aging requires reassessment. (80 references) (CH)

  9. Clusterin: an IR-inducible protein determining life and death

    International Nuclear Information System (INIS)

    DAVID A. BOOTHMAN

    2006-01-01

    The roles of ionizing radiation (IR)-inducible genes/proteins are now being elucidated and the research team will focus on the functions of the clusterin (CLU) proteins after low dose IR exposures. With funding from the DOE, we discovered that x-ray-inducible transcript/protein No.8 (xip8) bound to the Ku70 DNA double strand break repair protein using various molecular biology techniques. We showed that translation of the CLU/xip8 transcript was complicated, leading to two classes of proteins separated by their intracellular processing. One set of CLU proteins (a secreted and precursor protein, sCLU and psCLU, respectively) were induced by very low doses of IR (>2.0 cGy) and subsequently secreted from the cell. The functions of sCLU, particularly in bystander effects, are not known; sCLU does not bind Ku70, but can interact with the TGF-? II receptor. Another intracellular class of CLU proteins was targeted to the cytoplasm and existed in a dormant precursor nuclear form (pnCLU). After higher IR doses (>1.0 Gy), pnCLU was activated via post-translational modification, and translocated to the nucleus, where nuclear CLU (nCLU) interacted with Ku70/Ku80, and signaled cell death. The mechanism(s) of how cells die following nCLU accumulation are unknown. Recent data from our lab indicate that CLU gene transcription is also complicated. Thus far, the data suggest that: (a) p53 is a negative regulator of CLU transcription, however, the mechanisms by which it exerts this negative pressure are not known; and (b) IR induces transcription of the CLU promoter, independent of p53, at regulatory elements that lie between -1403 and -325 bps 5'-from the TATAA box. In this renewal, the research team will investigate three separate, but interrelated hypotheses: (1) p53 negatively regulates the CLU promoter via distinct head to tail p53 half sites, and induction is mediated by the combination of retinoblatoma control elements (RCEs) and NF-?B sites; (2) sCLU is cytoprotective and

  10. Clusterin: an IR-inducible protein determining life and death

    Energy Technology Data Exchange (ETDEWEB)

    DAVID A. BOOTHMAN, Ph.D.

    2006-07-11

    The roles of ionizing radiation (IR)-inducible genes/proteins are now being elucidated and the research team will focus on the functions of the clusterin (CLU) proteins after low dose IR exposures. With funding from the DOE, we discovered that x-ray-inducible transcript/protein #8 (xip8) bound to the Ku70 DNA double strand break repair protein using various molecular biology techniques. We showed that translation of the CLU/xip8 transcript was complicated, leading to two classes of proteins separated by their intracellular processing. One set of CLU proteins (a secreted and precursor protein, sCLU and psCLU, respectively) were induced by very low doses of IR (>2.0 cGy) and subsequently secreted from the cell. The functions of sCLU, particularly in bystander effects, are not known; sCLU does not bind Ku70, but can interact with the TGF-ß II receptor. Another intracellular class of CLU proteins was targeted to the cytoplasm and existed in a dormant precursor nuclear form (pnCLU). After higher IR doses (>1.0 Gy), pnCLU was activated via post-translational modification, and translocated to the nucleus, where nuclear CLU (nCLU) interacted with Ku70/Ku80, and signaled cell death. The mechanism(s) of how cells die following nCLU accumulation are unknown. Recent data from our lab indicate that CLU gene transcription is also complicated. Thus far, the data suggest that: (a) p53 is a negative regulator of CLU transcription, however, the mechanisms by which it exerts this negative pressure are not known; and (b) IR induces transcription of the CLU promoter, independent of p53, at regulatory elements that lie between -1403 and -325 bps 5'-from the TATAA box. In this renewal, the research team will investigate three separate, but interrelated hypotheses: (1) p53 negatively regulates the CLU promoter via distinct head to tail p53 half sites, and induction is mediated by the combination of retinoblatoma control elements (RCEs) and NF-∫B sites; (2) sCLU is cytoprotective

  11. The effect of residual stresses induced by prestraining on fatigue life of notched specimens

    Science.gov (United States)

    Sadeler, R.; Ozel, A.; Kaymaz, I.; Totik, Y.

    2005-06-01

    The effect of tensile prestraining-induced residual stress on the fatigue life of notched steel parts was investigated. The study was performed on AISI 4140 steel. Rotating bending fatigue tests were carried out on semicircular notched specimens with different notch radii in the as-quenched and tempered conditions. Metallography of the specimens was performed by means of light optical microscopy. The finite-element method was used to evaluate the residual stress distribution near the notch region. Fatigue tests revealed fatigue life improvement for notched specimens, which changes depending on the notch radii and applied stress. Scanning electron microscopy was used to examine the fracture surfaces of the specimens.

  12. Persistence of docetaxel-induced neuropathy and impact on quality of life among breast cancer survivors

    DEFF Research Database (Denmark)

    Eckhoff, L.; Knoop, A.; Jensen, M. B.

    2015-01-01

    BACKGROUND: This study evaluates persistence and severity of docetaxel-induced neuropathy (peripheral neuropathy (PN)) and impact on health related quality of life in survivors from early-stage breast cancer. METHODS: One thousand and thirty-one patients with early-stage breast cancer, who received...... at least one cycle of docetaxel and provided information on PN during treatment, completed questionnaires on PN as an outcome (Common Toxicity Criteria (CTC) scores, European Organisation for Research and Treatment of Cancer Chemotherapy-Induced Peripheral Neuropathy 20 (EORTC CIPN20) and EORTC Quality...

  13. Heparin-Induced Cardiac Tamponade and Life-Threatening Hyperkalemia in a Patient with Chronic Hemodialysis

    Directory of Open Access Journals (Sweden)

    Ho-Ming Su

    2005-03-01

    Full Text Available Heparin, a commonly used anticoagulant agent, is frequently used in patients undergoing hemodialysis. As with most medications, heparin has a significant side effect profile. Two of its most important side effects, major bleeding and hyperkalemia, may be devastating without immediate diagnosis and treatment. Major bleeding such as gastrointestinal, genitourinary or intracranial bleeding is occasionally encountered and rarely neglected. However, heparin-induced cardiac tamponade is rarely encountered and may be easily overlooked. Another side effect, heparin-induced hyperkalemia, an unusual but well-described side effect, is frequently forgotten until life-threatening arrhythmia has occurred. We report a case involving a 40-year-old male patient with uremia, who had received heparin for 10 days for deep vein thrombosis in the left lower extremity. Hemopericardium with cardiac tamponade and life-threatening hyperkalemia were both noted in this patient.

  14. Life-threatening bleeding in a case of autoantibody-induced factor VII deficiency.

    Science.gov (United States)

    Okajima, K; Ishii, M

    1999-02-01

    A male patient presented with life-threatening bleeding induced by autoantibody-induced factor VII (F.VII) deficiency. This patient had macroscopic hematuria, skin ecchymosis, gastrointestinal bleeding, and a neck hematoma that was causing disturbed respiration. He developed acute renal failure and acute hepatic failure, probably due to obstruction of the ureters and the biliary tract, respectively. Although activated partial thromboplastin time was normal, prothrombin time (PT) was remarkably prolonged at 71.8 seconds compared to 14.0 seconds in a normal control. Both the immunoreactive level of F.VII antigen and the F.VII activity of the patient's plasma samples were VII activity. These findings suggested the presence of a plasma inhibitor for F.VII. After administration of large doses of methylprednisolone, PT was gradually shortened and plasma levels of F.VII increased over time. Bleeding, acute renal failure, and acute hepatic failure improved markedly following the steroid treatment. These observations suggest that life-threatening bleeding can be induced by autoantibody-induced F.VII deficiency and that immunosuppressive therapy using large doses of steroid can be successful in inhibiting the production of the autoantibody.

  15. Ionotropic glutamate receptors mediate inducible defense in the water flea Daphnia pulex.

    Directory of Open Access Journals (Sweden)

    Hitoshi Miyakawa

    Full Text Available Phenotypic plasticity is the ability held in many organisms to produce different phenotypes with a given genome in response to environmental stimuli, such as temperature, nutrition and various biological interactions. It seems likely that environmental signals induce a variety of mechanistic responses that influence ontogenetic processes. Inducible defenses, in which prey animals alter their morphology, behavior and/or other traits to help protect against direct or latent predation threats, are among the most striking examples of phenotypic plasticity. The freshwater microcrustacean Daphnia pulex forms tooth-like defensive structures, "neckteeth," in response to chemical cues or signals, referred to as "kairomones," in this case released from phantom midge larvae, a predator of D. pulex. To identify factors involved in the reception and/or transmission of a kairomone, we used microarray analysis to identify genes up-regulated following a short period of exposure to the midge kairomone. In addition to identifying differentially expressed genes of unknown function, we also found significant up-regulation of genes encoding ionotropic glutamate receptors, which are known to be involved in neurotransmission in many animal species. Specific antagonists of these receptors strongly inhibit the formation of neckteeth in D. pulex, although agonists did not induce neckteeth by themselves, indicating that ionotropic glutamate receptors are necessary but not sufficient for early steps of neckteeth formation in D. pulex. Moreover, using co-exposure of D. pulex to antagonists and juvenile hormone (JH, which physiologically mediates neckteeth formation, we found evidence suggesting that the inhibitory effect of antagonists is not due to direct inhibition of JH synthesis/secretion. Our findings not only provide a candidate molecule required for the inducible defense response in D. pulex, but also will contribute to the understanding of complex mechanisms

  16. Rivaroxaban-Induced Nontraumatic Spinal Subdural Hematoma: An Uncommon Yet Life-Threatening Complication

    Directory of Open Access Journals (Sweden)

    Mazen Zaarour

    2015-01-01

    Full Text Available In the last decade, the desire for safer oral anticoagulants (OACs led to the emergence of newer drugs. Available clinical trials demonstrated a lower risk of OACs-associated life-threatening bleeding events, including intracranial hemorrhage, compared to warfarin. Nontraumatic spinal hematoma is an uncommon yet life-threatening neurosurgical emergency that can be associated with the use of these agents. Rivaroxaban, one of the newly approved OACs, is a direct factor Xa inhibitor. To the best of our knowledge, to date, only two published cases report the incidence of rivaroxaban-induced nontraumatic spinal subdural hematoma (SSDH. Our case is the third one described and the first one to involve the cervicothoracic spine.

  17. Radiation-induced life shortening in neonatally thymectomized germ-free mice

    International Nuclear Information System (INIS)

    Anderson, R.E.; Howarth, J.L.; Troup, G.M.

    1980-01-01

    Radiation in sufficient amounts is carcinogenic, immunosuppressive, and results in a reduced life span. Similar consequences follow neonatal thymectomy (nTx) in some strains of rodents. The tumorigenic effects of irradiation appear to be partly mediated via suppression of the thymus-dependent portion of the immune response. Our purpose was to determine whether a similar relationship exists for radiation-induced accelerated aging. Female germ-free Charles River mice had neonatal or sham thymectomies within 24 hours of birth. Half of each group was exposed to 700 rads at 6 weeks of age. When mice with histologically malignant tumors were excluded, the combined life-shortening effects of nTx and irradiation were less pronounced than the sum of the individual effects. This suggests that some of the decreased longevity associated with irradiation may be mediated by T-cell injury

  18. Effect of residual stresses induced by prestressing on rolling element fatigue life

    Science.gov (United States)

    Parker, R. J.; Zaretsky, E. V.

    1972-01-01

    A mechanical prestress cycle suitable to induce compressive stress beneath the surface of the inner race of radially loaded 207-size bearings was determined. Compressive residual stress in excess 0.69 x 10 to the 9th power N/sq m (100,000 psi), as measured by X-ray diffraction, were induced at the depth of maximum shearing stress. The prestress cycle consisted of running the bearings for 25 hours at 2750 rpm at a radial load which produced a maximum Hertz stress of 3.3 x 10 to the 9th power N/sq m (480,000 psi) at the contact of the inner race and the heaviest loaded ball. Bearings subjected to this prestress cycle and subsequently fatigue tested gave a 10 percent fatigue life greater than twice that of a group of baseline bearings.

  19. Transfer of an induced preferred retinal locus of fixation to everyday life visual tasks.

    Science.gov (United States)

    Barraza-Bernal, Maria J; Rifai, Katharina; Wahl, Siegfried

    2017-12-01

    Subjects develop a preferred retinal locus of fixation (PRL) under simulation of central scotoma. If systematic relocations are applied to the stimulus position, PRLs manifest at a location in favor of the stimulus relocation. The present study investigates whether the induced PRL is transferred to important visual tasks in daily life, namely pursuit eye movements, signage reading, and text reading. Fifteen subjects with normal sight participated in the study. To develop a PRL, all subjects underwent a scotoma simulation in a prior study, where five subjects were trained to develop the PRL in the left hemifield, five different subjects on the right hemifield, and the remaining five subjects could naturally chose the PRL location. The position of this PRL was used as baseline. Under central scotoma simulation, subjects performed a pursuit task, a signage reading task, and a reading-text task. In addition, retention of the behavior was also studied. Results showed that the PRL position was transferred to the pursuit task and that the vertical location of the PRL was maintained on the text reading task. However, when reading signage, a function-driven change in PRL location was observed. In addition, retention of the PRL position was observed over weeks and months. These results indicate that PRL positions can be induced and may further transferred to everyday life visual tasks, without hindering function-driven changes in PRL position.

  20. Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity.

    Science.gov (United States)

    Gazea, Mary; Patchev, Alexandre V; Anderzhanova, Elmira; Leidmaa, Este; Pissioti, Anna; Flachskamm, Cornelia; Almeida, Osborne F X; Kimura, Mayumi

    2018-01-10

    Early-life obesity predisposes to obesity in adulthood, a condition with broad medical implications including sleep disorders, which can exacerbate metabolic disturbances and disrupt cognitive and affective behaviors. In this study, we examined the long-term impact of transient peripubertal diet-induced obesity (ppDIO, induced between 4 and 10 weeks of age) on sleep-wake behavior in male mice. EEG and EMG recordings revealed that ppDIO increases sleep during the active phase but reduces resting-phase sleep quality. This impaired sleep phenotype persisted for up to 1 year, although animals were returned to a non-obesiogenic diet from postnatal week 11 onwards. To better understand the mechanisms responsible for the ppDIO-induced alterations in sleep, we focused on the lateral hypothalamus (LH). Mice exposed to ppDIO did not show altered mRNA expression levels of orexin and melanin-concentrating hormone, two peptides that are important for sleep-wake behavior and food intake. Conversely, the LH of ppDIO-exposed mice had reduced contents of serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter involved in both sleep-wake and satiety regulation. Interestingly, an acute peripheral injection of the satiety-signaling peptide YY 3-36 increased 5-HT turnover in the LH and ameliorated the ppDIO-induced sleep disturbances, suggesting the therapeutic potential of this peptide. These findings provide new insights into how sleep-wake behavior is programmed during early life and how peripheral and central signals are integrated to coordinate sleep. SIGNIFICANCE STATEMENT Adult physiology and behavior are strongly influenced by dynamic reorganization of the brain during puberty. The present work shows that obesity during puberty leads to persistently dysregulated patterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothalamus. It also shows that pharmacological mimicry of satiety with peptide YY 3-36 can reverse this neurochemical imbalance and

  1. Opioid-induced constipation, use of laxatives, and health-related quality of life.

    Science.gov (United States)

    Christensen, Helene Nordahl; Olsson, Urban; From, Jesper; Breivik, Harald

    2016-04-01

    Real-life data on laxative use in patients suffering from opioid-induced constipation (OIC) are very limited, and many OIC patients are only using over the counter laxatives to resolve their constipation. Our aim was to describe laxative utilization and quality of life in participants in Norway who ever experienced OIC. This was a cross-sectional online survey conducted between 27th of June and 3rd of July 2014 among participants above 18 years with self-reported OIC and who had agreed to receive information from the pharmacy chain (Boots A/S, Norway). The questionnaire comprised a series of multiple choice, close-ended, and free text questions on abdominal symptoms, laxative use and health-related quality of life. A total of 417 participants met the study eligibility criteria: (1) treated with opioid for a minimum of 4 weeks, (2) actively accepted participation, and (3) confirmed ever experiencing OIC and in addition completed the survey. Among the eligible participants, 86% were females, 85% were younger than 60 years of age, and 57% were currently suffering OIC. More than half of the currently constipated participants were experiencing moderate to very severe abdominal bloating (63%), abdominal pain (55%) and/or pain during bowel movement (50%). Less than every fourth participant (23%) had consulted health care professionals (HCPs) about their constipation. Up to 39% reported that they handled their OIC by self-management, e.g., bought laxative, reduced the dose and/or changed opioid without consulting HCP or pharmacy. Less than half (48%) of the laxative users were satisfied with the laxative they were using to relieve their constipation. The EQ-5D health-related quality of life score was mean (SD): 0.587 (0.272). Although not statistically significant (p=0.067), there was a tendency of lower quality of life among the participants who were currently constipated compared with those not currently constipated (difference of mean EQ-5D: 0.629-0.555=0.074). A

  2. Sex differences in stress-induced visceral hypersensitivity following early life adversity: a two hit model.

    Science.gov (United States)

    Prusator, D K; Greenwood-Van Meerveld, B

    2016-12-01

    Early life adversity (ELA) has been indicated as a risk factor for the development of stress axis dysfunction in adulthood, specifically in females. We previously showed that unpredictable ELA induces visceral hyperalgesia in adult female rats. It remains to be determined whether ELA alters visceral nociceptive responses to stress in adulthood. The current study tested the hypothesis that following ELA, exposure to an adulthood stressor, or second hit, serves as a risk factor for exaggerated stress-induced visceral hypersensitivity that is sex-specific. Following ELA, adult stress was induced via a single exposure (acute) or repetitive daily exposure, 1 h/day for 7 days (chronic), to water avoidance stress (WAS). Acute WAS increased pain behaviors in all adult female rats, however, females that experienced unpredictable ELA exhibited significantly more pain behaviors compared to those exposed to predictable ELA or controls. Following chronic WAS, all adult females exhibited increased pain responses, however, an exaggerated response was observed in rats exposed to unpredictable or predictable ELA compared to controls. Similarly, in adult male rats exposure to acute or chronic WAS increased pain behaviors, however, there were no differences in pain behaviors between ELA groups. This study highlights a novel consequence of ELA on stress-induced visceral nociception in adulthood that is sex-specific. More importantly, our study suggests that ELA not only serves as a risk factor for development of chronic pain in adulthood, but also serves as a predisposition for worsening of visceral pain following adult stress in female rats. © 2016 John Wiley & Sons Ltd.

  3. Occupational noise-induced tinnitus: does it affect workers' quality of life?

    Science.gov (United States)

    Muluk, Nuray Bayar; Oguztürk, Omer

    2008-02-01

    This prospective study aimed to investigate the quality of life of workers in a steel factory. The study group was composed of 16 male workers with tinnitus and 30 ears. Fifteen male workers without tinnitus and 30 ears were included into the control group. Workers were evaluated by questionnaire, pure-tone audiometry, and the SF-36 Health Survey. In the study group, tinnitus loudness levels (TLLs) were found. In the study group, the domains general mental health and role limitations owing to emotional problems were significantly lower than in the control group. Older age, industrial noise exposure over a long period, higher noise exposure during work, and hearing loss secondary to occupational noise caused workers to experience higher TLLs. Earheadings protected workers more than earplugs, and TLLs were lower. Important factors that affect workers' quality of life are maximum exposed noise levels, daily and total noise exposure time, and exposure to continuous noise. Occupational noise-induced tinnitus mainly causes emotional disability rather than physical disability. Emotionally impaired QOL results may be due to tinnitus-related psychological problems. Workers should have knowledge about the hazardous effects of noise. Periodic health checkups and regular seminars have great importance. Workers must be aware of other ototoxic factors, such as medications and noisy music. In the future, researchers should develop a screening method to detect those with a more hereditary affinity to hearing loss.

  4. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia

    Directory of Open Access Journals (Sweden)

    Jessica L. Bolton

    2018-02-01

    Full Text Available Early-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model of childhood adversity (i.e., rearing pups for one week in cages with limited bedding and nesting, LBN. Drug use and addiction are highly comorbid with psychiatric disorders featuring anhedonia, yet effects of LBN on drug-seeking behavior and the reward and stress-related circuits that underlie it remain unknown. Here we examined the effects of LBN on cocaine intake and seeking, using a battery of behavioral tests measuring distinct aspects of cocaine reward, and for comparison, chocolate intake. We also examined activation of neurons within the pleasure/reward and stress circuits following cocaine in LBN and control rats. Early-life adversity reduced spontaneous intake of palatable chocolate, extending prior reports of sucrose and social-play anhedonia. In a within-session cocaine behavioral economic test, LBN rats self-administered lower dosages of cocaine under low-effort conditions, consistent with a reduced hedonic set-point for cocaine, and potentially anhedonia. In contrast, cocaine demand elasticity was not consistently affected, indicating no major changes in motivation to maintain preferred cocaine blood levels. These changes were selective, as LBN did not cause an overt anxiety-like phenotype, nor did it affect sensitivity to self-administered cocaine dose, responding for cocaine under extinction conditions, cocaine- or cue-induced reinstatement of cocaine seeking, or locomotor response to acute cocaine. However, high Fos expression was seen after cocaine in both reward- and stress-related brain regions of LBN rats, including nucleus accumbens core, central amygdala, and lateral habenula. In contrast, hypothalamic orexin neuron activation after cocaine was significantly attenuated in LBN rats. Together, these findings demonstrate

  5. Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice

    Directory of Open Access Journals (Sweden)

    Asquith Kelly L

    2010-02-01

    Full Text Available Abstract Background Early-life respiratory viral infections, notably with respiratory syncytial virus (RSV, increase the risk of subsequent development of childhood asthma. The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure predisposed to the development of features of asthma. Methods We employed a unique combination of animal models in which BALB/c mice were neonatally infected with pneumonia virus of mice (PVM, which replicates severe RSV disease in human infants and following recovery, were intranasally sensitised with ovalbumin. Animals received low-level challenge with aerosolised antigen for 4 weeks to elicit changes of chronic asthma, followed by a single moderate-level challenge to induce an exacerbation of inflammation. We then assessed airway inflammation, epithelial changes characteristic of remodelling, airway hyperresponsiveness (AHR and host immunological responses. Results Allergic airway inflammation, including recruitment of eosinophils, was prominent only in animals that had recovered from neonatal infection with PVM and then been sensitised and chronically challenged with antigen. Furthermore, only these mice exhibited an augmented Th2-biased immune response, including elevated serum levels of anti-ovalbumin IgE and IgG1 as well as increased relative expression of Th2-associated cytokines IL-4, IL-5 and IL-13. By comparison, development of AHR and mucous cell change were associated with recovery from PVM infection, regardless of subsequent allergen challenge. Increased expression of IL-25, which could contribute to induction of a Th2 response, was demonstrable in the lung following PVM infection. Signalling via the IL-4 receptor α chain was crucial to the development of allergic inflammation, mucous cell change and AHR, because all of these were absent in receptor-deficient mice. In contrast, changes of remodelling were evident in mice

  6. Small for Gestational Age and Magnesium: Intrauterine magnesium deficiency may induce metabolic syndrome in later life

    Directory of Open Access Journals (Sweden)

    Junji Takaya

    2015-12-01

    Full Text Available Magnesium deficiency during pregnancy as a result of insufficient or low intake of magnesium is common in developing and developed countries. Previous reports have shown that intracellular magnesium of cord blood platelets is lower among small for gestational age (SGA groups than that of appropriate for gestational age (AGA groups, suggesting that intrauterine magnesium deficiency may result in SGA. Additionally, the risk of adult-onset diseases such as insulin resistance syndrome is greater among children whose mothers were malnourished during pregnancy, and who consequently had a low birth weight. In a number of animal models, poor nutrition during pregnancy leads to offspring that exhibit pathophysiological changes similar to human diseases. The offspring of pregnant rats fed a magensium restricted diet have developed hypermethylation in the hepatic 11β-hydroxysteroid dehydrogenase-2 promoter. These findings indicate that maternal magnesium deficiencies during pregnancy influence regulation of non-imprinted genes by altering the epigenetic regulation of gene expression, thereby inducing different metabolic phenotypes. Magnesium deficiency during pregnancy may be responsible for not only maternal and fetal nutritional problems, but also lifelong consequences that affect the offspring throughout their life. Epidemiological, clinical, and basic research on the effects of magnesium deficiency now indicates underlying mechanisms, especially epigenetic processes.

  7. Prevention of radiation induced xerostomia and improved quality of life: Submandibular salivary gland transfer

    International Nuclear Information System (INIS)

    Heck, K.

    2003-01-01

    Over 60,000 new cases of head and neck cancers, and approximately 15,000 deaths occur every year in the United States (1). Head and neck cancers affect more men then women by a factor of 2:1, although the incidence of women is increasing as a result of increased tobacco use (2). Over 90% of all head and neck cancers are squamous cell carcinomas; most of the remaining cancers are adenocarcinomas. A combination of radiation therapy and surgery is used as the standard, primary treatment modality. Xerostomia occurs when the salivary glands are affected by irradiation. Patients experiencing xerostomia are at an increased risk for a wide variety of oral problems; all adversely affecting one's quality of life. Currently patients make lifestyle changes, dietary modifications, and use artificial salivas, sprays, gels, and lozenges to help mask their xerostomia. However, none of these products stimulate natural salivary production and act as a replacement therapy rather then a cure for xerostomia. A new protocol, RTOG 1083 has been approved by the Radiation Therapy Oncology Group, which involves a surgical transfer of a submandibular salivary gland to the submental space (where it can be easily shielded) as a method of prevention of radiation induced xerostomia. (author)

  8. On the possibility of galactic cosmic ray-induced radiolysis-powered life in subsurface environments in the Universe.

    Science.gov (United States)

    Atri, Dimitra

    2016-10-01

    Photosynthesis is a mechanism developed by terrestrial life to utilize the energy from photons of solar origin for biological use. Subsurface regions are isolated from the photosphere, and consequently are incapable of utilizing this energy. This opens up the opportunity for life to evolve alternative mechanisms for harvesting available energy. Bacterium Candidatus Desulforudis audaxviator, found 2.8 km deep in a South African mine, harvests energy from radiolysis, induced by particles emitted from radioactive U, Th and K present in surrounding rock. Another radiation source in the subsurface environments is secondary particles generated by galactic cosmic rays (GCRs). Using Monte Carlo simulations, it is shown that it is a steady source of energy comparable to that produced by radioactive substances, and the possibility of a slow metabolizing life flourishing on it cannot be ruled out. Two mechanisms are proposed through which GCR-induced secondary particles can be utilized for biological use in subsurface environments: (i) GCRs injecting energy in the environment through particle-induced radiolysis and (ii) organic synthesis from GCR secondaries interacting with the medium. Laboratory experiments to test these hypotheses are also proposed. Implications of these mechanisms on finding life in the Solar System and elsewhere in the Universe are discussed. © 2016 The Author(s).

  9. Are light traps baited with kairomones effective in the capture of Lutzomyia longipalpis and Lutzomyia intermedia? An evaluation of synthetic human odor as an attractant for phlebotomine sand flies (Diptera: Psychodidae: Phlebotominae).

    Science.gov (United States)

    Andrade, Andrey J; Andrade, Mateus R; Dias, Edelberto S; Pinto, Mara C; Eiras, Alvaro E

    2008-06-01

    Phlebotomine sand flies are often captured with human bait and/or light traps, either with or without an animal bait. More recently, synthetic attractants have been used as bait in traps to improve the capture of phlebotomine sand flies as well as other insects of medical and veterinary importance. The aim of the present study was to evaluate the effects of the kairomone 1-octen-3-ol (octenol) and the synthetic human odor BG-Mesh Lure (BGML--lactic acid, caproic acid and ammonia) baited in modified CDC light traps on the capture of phlebotomine sand flies. The experiments followed the 5x5 Latin square design. Among the species caught, Lutzomyia intermedia apparently presented a dose-dependent response to octenol. The response obtained with the BGML, alone or in combination with octenol (5 mg/h), indicated some degree of attractiveness of these baits to different phlebotomine sand fly species. Octenol seems to be more attractive to L. intermedia than to Lutzomyia longipalpis, while the BGML presented a higher success in capturing L. longipalpis. When the components of the BGML were used separately, there was no increase in catching the female of L. intermedia. Apparently, there was no synergistic effect between the octenol and the BGML. In conclusion, the octenol and the BGML were demonstrated to be possible baits to attract some phlebotomine sand fly species.

  10. Specific synbiotics in early life protect against diet-induced obesity in adult mice

    NARCIS (Netherlands)

    Mischke, Mona; Arora, Tulika; Tims, Sebastian; Engels, Eefje; Sommer, Nina; Limpt, van Kees; Baars, Annemarie; Oozeer, Raish; Oosting, Annemarie; Bäckhed, Fredrik; Knol, Jan

    2018-01-01

    Aims: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health throughout life. Here, we determined how beneficial microbiome interventions in early life

  11. Specific synbiotics in early life protect against diet-induced obesity in adult mice

    DEFF Research Database (Denmark)

    Mischke, Mona; Arora, Tulika; Tims, Sebastian

    2018-01-01

    AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how beneficial microbiome interventions in early life a...... as preventive measure to ameliorate obesity risk and improve metabolic health throughout life....

  12. Chemogenetic activation of the lateral hypothalamus reverses early life stress-induced deficits in motivational drive.

    Science.gov (United States)

    Campbell, Erin J; Mitchell, Caitlin S; Adams, Cameron D; Yeoh, Jiann Wei; Hodgson, Deborah M; Graham, Brett A; Dayas, Christopher V

    2017-10-01

    Altered motivated behaviour is a cardinal feature of several neuropsychiatric conditions including mood disorders. One well-characterized antecedent to the development of mood disorders is exposure to early life stress (ELS). A key brain substrate controlling motivated behaviour is the lateral hypothalamus (LH). Here, we examined the effect of ELS on LH activation and the motivation to self-administer sucrose. We tested whether chemogenetic activation of LH circuits could modify sucrose responding in ELS rats and examined the impact on LH cell populations. Male rat pups were maternally separated for 0 or 3 h on postnatal days 2-14. During adolescence, rats received bilateral injections of hM3D(Gq), the excitatory designer receptor exclusively activated by designer drugs, into LH. In adulthood, rats were trained to self-administer sucrose and tested under a progressive ratio schedule to determine their motivation for reward following injection with either vehicle or 5 mg/kg clozapine-N-oxide. Brains were processed for Fos-protein immunohistochemistry. ELS significantly suppressed lever responding for sucrose, indicating a long-lasting impact of ELS on motivation circuits. hM3D(Gq) activation of LH increased responding, normalizing deficits in ELS rats, and increased Fos-positive orexin and MCH cell numbers within LH. Our findings indicate that despite being susceptible to environmental stressors, LH circuits retain the capacity to overcome ELS-induced deficits in motivated behaviour. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  13. Sucrose-induced analgesia during early life modulates adulthood learning and memory formation.

    Science.gov (United States)

    Nuseir, Khawla Q; Alzoubi, Karem H; Alabwaini, Jehad; Khabour, Omar F; Kassab, Manal I

    2015-06-01

    This study is aimed at examining the long-term effects of chronic pain during early life (postnatal day 0 to 8weeks), and intervention using sucrose, on cognitive functions during adulthood in rats. Pain was induced in rat pups via needle pricks of the paws. Sucrose solution or paracetamol was administered for analgesia before the paw prick. Control groups include tactile stimulation to account for handling and touching the paws, and sucrose alone was used. All treatments were started on day one of birth and continued for 8weeks. At the end of the treatments, behavioral studies were conducted to test the spatial learning and memory using radial arm water maze (RAWM), as well as pain threshold via foot-withdrawal response to a hot plate apparatus. Additionally, the hippocampus was dissected, and blood was collected. Levels of neurotrophins (BDNF, IGF-1 and NT-3) and endorphins were assessed using ELISA. The results show that chronic noxious stimulation resulted in comparable foot-withdrawal latency between noxious and tactile groups. On the other hand, pretreatment with sucrose or paracetamol increased pain threshold significantly both in naive rats and noxiously stimulated rats (Pmemory, and sucrose treatment prevented such impairment (Pmemory impairment, and pretreatment with sucrose prevented this impairment via mechanisms that seem to involve BDNF. As evident in the results, sucrose, whether alone or in the presence of pre-noxious stimulation, increases pain threshold in such circumstances; most likely via a mechanism that involves an increase in endogenous opioids. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Laser induced fluorescence emission (L.I.F.E.): in situ and remote detection of life in Antarctic and Alaskan ice

    Science.gov (United States)

    Storrie-Lombardi, Michael C.; Sattler, Birgit

    2009-08-01

    Once thought to be a barren desert devoid of life, it now appears that Earth's cryosphere is an ice ecosystem harbouring a rich community of metabolically active microorganisms inhabiting ice, snow, water, and lithic environments. The ability to rapidly survey this ecosystem during in situ and orbital missions is of considerable interest for monitoring Earth's carbon budget and for efficiently searching for life on Mars or any exoplanet with an analogous cryosphere. Laser induced fluorescence emission (L.I.F.E.) imaging and spectroscopy using excitation in ultraviolet (UV) wavelengths have been proposed as non-destructive astrobiological survey tools to search for amino acids, nucleic acids, microbial life, and polycyclic aromatic hydrocarbons (PAHs) deep in the Mars regolith. However, the technique is easily adapted to search for larger, more complex biomolecular targets using longer wavelength sources. Of particular interest is the ability for excitation at blue, green, and red wavelengths to produce visible and near infrared fluorescence of photosynthetic pigments in cyanobacteria-dominated microbial communities populating the ice of alpine, Arctic, and Antarctic lakes, glaciers, ice sheets, and even the supercooled water-ice droplets of clouds. During the Tawani 2008 International Antarctic Expedition we tested the in situ use of the technique as part of a field campaign in the Dry Valleys of Schirmacher Oasis and Lake Untersee, Queen Maud Land, Antarctica. In the spring of 2009, we performed airborne remote sensing tests of the technology in Alaska. In this paper we review our in situ laser detection experiments and present for the first time preliminary results on our efforts to detect cryosphere L.I.F.E. from an airborne platform.

  15. 3D additive manufactured 316L components microstructural features and changes induced by working life cycles

    Science.gov (United States)

    Pace, M. L.; Guarnaccio, A.; Dolce, P.; Mollica, D.; Parisi, G. P.; Lettino, A.; Medici, L.; Summa, V.; Ciancio, R.; Santagata, A.

    2017-10-01

    The ability of processing through laser beams different kinds of metallic powders for direct production of 3D components with complex geometries has been gaining an impressive and growing attention for specific industrial applications. The process which can be distinguished as Selective Laser Sintering or Selective Laser Melting is even considered, more generally, as Additive Manufacturing where layer by layer material is built by the interaction between a laser beam and a powder bed. The rapid heating of the powder due to the laser beam energy transfer process followed by a rapid cooling rate induces within the manufactured material a cellular structure with fine sub-grains, which are in the range of few hundreds of micrometers. These metastable structures, which are smaller than the grain size in conventionally manufactured 316L stainless steel components, can undertake towards a recrystallization process due to either heat or mechanical treatments. For instance, when sub-grain boundaries of the cells are enriched with Mo and higher concentration of dislocation, dynamical processes occur generating local residual stresses. In these circumstances the segregation of Mo in cell boundaries is out of thermodynamic equilibrium conditions so that microstructures and phases are metastable. In the range of 1100-1400 °C heat treatments a complete dissolution of Mo in the Fe matrix with a gradual disappearance of sub-microns cell is observed feeding the growth of larger austenitic sub-grains formation. It follows a higher degree of Mo dissolution in the material matrix and a decrease of dislocation's concentration (Saeidi et al., 2015) [1]. In the work here presented we point out which are the microstructural features of stainless steel 316L components realized by Additive Manufacturing. Furthermore, the occurrence of a microstructural evolution is presented after experiencing to fatigue of 80000 cycles some door joints obtained by this technique. A decrease of dislocation

  16. The combined effect of bottom-up and top-down factors on life history and reproduction of Daphnia in the field: is a strategic dilemma underlying population declines?

    Directory of Open Access Journals (Sweden)

    Stephan HÜLSMANN

    2011-08-01

    Full Text Available In a detailed field study covering three years, population dynamics, life history shifts and reproductive patterns of a population of Daphnia galeata were investigated in relation to food availability and dynamics of young of the year fish, the main vertebrate predators. In all years an increase of Daphnia abundance in spring was associated with declining food conditions (clear water stage. The size at maturity (SAM during this period was high and even increased, brood size declined, while egg volume increased. These patterns may be explained as response to food limitation. A decline of Daphnia abundance in every year was associated with increasing food conditions and the end of the clear water stage. Egg volumes as well as the size of egg-carrying daphnids also decreased, while brood size remained at low values. In two years in which these changes were particularly pronounced, the available fish data suggest that both the biomass (determining predation pressure, as well as the size of the fish (determining size selection are important for the observed dynamics. No decrease of SAM occurred as long as fish were smaller than 25 mm TL, when they are still gape-limited and not able to feed on the largest size-classes of Daphnia. Although fish biomass, which should correspond to kairomone level, would have suggested a reduction of SAM as induced defence, probably the selection of small (egg-carrying daphnids by small fish, besides severe food limitation, prevented this response to become effective. The sudden decline of SAM at the end of the clear water stage may not be explained by gradual phenotypic responses or indirect demographic effects, but must be due to an alternation of generations. SAM may be further reduced by direct and indirect effects of predation, interacting with increasing food levels. The Daphnia population is most vulnerable to predation at the time when the new generation takes over. Consequently, predation impact depends on

  17. Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish

    Energy Technology Data Exchange (ETDEWEB)

    Tu, Tzu-Yi; Hong, Chwan-Yang [Department of Agricultural Chemistry, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan (China); Sasado, Takao [Laboratory of Bioresources, National Institute for Basic Biology, Okazaki (Japan); Kashiwada, Shosaku [Research Center for Life and Environmental Sciences, Department of Life Sciences, the Toyo University, Gunma (Japan); Chen, Pei-Jen, E-mail: chenpj@ntu.edu.tw [Department of Agricultural Chemistry, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan (China)

    2016-01-15

    Highlights: • Propiconazole initiates ROS-induced oxidative stress and damage in medaka fish. • Early life exposure to propiconazole increases incidence of hepatocarcionogensis in p53{sup −/−} medaka. • Oxidative stress and CYP induction involved in p53 regulation are key events in propiconazole-induced hepatotumorigenesis. • Propiconazole-induced toxic response in medaka is compatible with that in rodents. - Abstract: Conazole pollution is an emerging concern to human health and environmental safety because of the broad use of conazole fungicides in agriculture and medicine and their frequent occurrence in aquifers. The agricultural pesticide propiconazole has received much regulatory interest because it is a known rodent carcinogen with evidence of multiple adverse effects in mammals and non-targeted organisms. However, the carcinogenic effect and associated mechanism of propiconazole in fish under microgram-per-liter levels of environmental-relevant exposure remains unclear. To explore whether early life of propiconzaole exposure would induce oxidative stress and latent carcinogenic effects in fish, we continuously exposed larvae of wild type or p53{sup −/−} mutant of medaka fish (Oryzias latipes) to propiconazole (2.5–250 μg/L) for 3, 7, 14 or 28 days and assessed liver histopathology and/or the oxidative stress response and gene expression during exposure and throughout adulthood. Propiconazole dose-dependently induced reactive oxygen species (ROS) level, altered homeostasis of antioxidant superoxide dismutase, catalase and glutathione S-transferase and caused lipid and protein peroxidation during early life exposure in wild type medaka. Such exposure also significantly upregulated gene expression of the cytochrome P450 CYP1A, but marginally suppressed that of tumor suppressor p53 in adults. Furthermore, histopathology revealed that p53{sup −/−} mutant medaka with early life exposure to propiconazole showed increased incidence of

  18. Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish

    International Nuclear Information System (INIS)

    Tu, Tzu-Yi; Hong, Chwan-Yang; Sasado, Takao; Kashiwada, Shosaku; Chen, Pei-Jen

    2016-01-01

    Highlights: • Propiconazole initiates ROS-induced oxidative stress and damage in medaka fish. • Early life exposure to propiconazole increases incidence of hepatocarcionogensis in p53"−"/"− medaka. • Oxidative stress and CYP induction involved in p53 regulation are key events in propiconazole-induced hepatotumorigenesis. • Propiconazole-induced toxic response in medaka is compatible with that in rodents. - Abstract: Conazole pollution is an emerging concern to human health and environmental safety because of the broad use of conazole fungicides in agriculture and medicine and their frequent occurrence in aquifers. The agricultural pesticide propiconazole has received much regulatory interest because it is a known rodent carcinogen with evidence of multiple adverse effects in mammals and non-targeted organisms. However, the carcinogenic effect and associated mechanism of propiconazole in fish under microgram-per-liter levels of environmental-relevant exposure remains unclear. To explore whether early life of propiconzaole exposure would induce oxidative stress and latent carcinogenic effects in fish, we continuously exposed larvae of wild type or p53"−"/"− mutant of medaka fish (Oryzias latipes) to propiconazole (2.5–250 μg/L) for 3, 7, 14 or 28 days and assessed liver histopathology and/or the oxidative stress response and gene expression during exposure and throughout adulthood. Propiconazole dose-dependently induced reactive oxygen species (ROS) level, altered homeostasis of antioxidant superoxide dismutase, catalase and glutathione S-transferase and caused lipid and protein peroxidation during early life exposure in wild type medaka. Such exposure also significantly upregulated gene expression of the cytochrome P450 CYP1A, but marginally suppressed that of tumor suppressor p53 in adults. Furthermore, histopathology revealed that p53"−"/"− mutant medaka with early life exposure to propiconazole showed increased incidence of

  19. Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages.

    Science.gov (United States)

    Xu, Lanlan; Peng, Xiao; Yu, Deliang; Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng

    2016-08-01

    Cadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by local residents. Evidences indicate that the early stages of marine organisms are more sensitive to metal contaminants. In this study, we applied two-dimensional electrophoresis-based proteomics to characterize the biological effects of Cd (50 μg L(-1)) in the early life stages (D-shape larval and juvenile) of mussels. The different proteomic responses demonstrated the differential responsive mechanisms to Cd exposure in these two early life stages of mussels. In details, results indicated that Cd mainly induced immune and oxidative stresses in both D-shape larval and juvenile mussels via different pathways. In addition, the significant up-regulation of triosephosphate isomerase and metallothionein confirmed the enhanced energy demand and mobilized detoxification mechanism in D-shape larval mussels exposed to Cd. In juvenile mussels, Cd exposure also induced clear apoptosis. Overall, this work suggests that Cd is a potential immune toxicant to mussel M. galloprovincialis at early life stages. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Perinatal BPA Exposure Induces Hyperglycemia, Oxidative Stress and Decreased Adiponectin Production in Later Life of Male Rat Offspring

    Directory of Open Access Journals (Sweden)

    Shunzhe Song

    2014-04-01

    Full Text Available The main object of the present study was to explore the effect of perinatal bisphenol A (BPA exposure on glucose metabolism in early and later life of male rat offspring, and to establish the potential mechanism of BPA-induced dysglycemia. Pregnant rats were treated with either vehicle or BPA by drinking water at concentrations of 1 and 10 µg/mL BPA from gestation day 6 through the end of lactation. We measured the levels of fasting serum glucose, insulin, adiponectin and parameters of oxidative stress on postnatal day (PND 50 and PND100 in male offspring, and adiponectin mRNA and protein expression in adipose tissue were also examined. Our results showed that perinatal exposure to 1 or 10 µg/mL BPA induced hyperglycemia with insulin resistance on PND100, but only 10 µg/mL BPA exposure had similar effects as early as PND50. In addition, increased oxidative stress and decreased adiponectin production were also observed in BPA exposed male offspring. Our findings indicated that perinatal exposure to BPA resulted in abnormal glucose metabolism in later life of male offspring, with an earlier and more exacerbated effect at higher doses. Down-regulated expression of adiponectin gene and increased oxidative stress induced by BPA may be associated with insulin resistance.

  1. Roles of density-dependent growth and life history evolution in accounting for fisheries-induced trait changes.

    Science.gov (United States)

    Eikeset, Anne Maria; Dunlop, Erin S; Heino, Mikko; Storvik, Geir; Stenseth, Nils C; Dieckmann, Ulf

    2016-12-27

    The relative roles of density dependence and life history evolution in contributing to rapid fisheries-induced trait changes remain debated. In the 1930s, northeast Arctic cod (Gadus morhua), currently the world's largest cod stock, experienced a shift from a traditional spawning-ground fishery to an industrial trawl fishery with elevated exploitation in the stock's feeding grounds. Since then, age and length at maturation have declined dramatically, a trend paralleled in other exploited stocks worldwide. These trends can be explained by demographic truncation of the population's age structure, phenotypic plasticity in maturation arising through density-dependent growth, fisheries-induced evolution favoring faster-growing or earlier-maturing fish, or a combination of these processes. Here, we use a multitrait eco-evolutionary model to assess the capacity of these processes to reproduce 74 y of historical data on age and length at maturation in northeast Arctic cod, while mimicking the stock's historical harvesting regime. Our results show that model predictions critically depend on the assumed density dependence of growth: when this is weak, life history evolution might be necessary to prevent stock collapse, whereas when a stronger density dependence estimated from recent data is used, the role of evolution in explaining fisheries-induced trait changes is diminished. Our integrative analysis of density-dependent growth, multitrait evolution, and stock-specific time series data underscores the importance of jointly considering evolutionary and ecological processes, enabling a more comprehensive perspective on empirically observed stock dynamics than previous studies could provide.

  2. Intrinsic vs. extrinsic influences on life history expression: metabolism and parentally induced temperature influences on embryo development rate

    Science.gov (United States)

    Martin, Thomas E.; Ton, Riccardo; Nikilson, Alina

    2013-01-01

    Intrinsic processes are assumed to underlie life history expression and trade-offs, but extrinsic inputs are theorised to shift trait expression and mask trade-offs within species. Here, we explore application of this theory across species. We do this based on parentally induced embryo temperature as an extrinsic input, and mass-specific embryo metabolism as an intrinsic process, underlying embryonic development rate. We found that embryonic metabolism followed intrinsic allometry rules among 49 songbird species from temperate and tropical sites. Extrinsic inputs via parentally induced temperatures explained the majority of variation in development rates and masked a relationship with metabolism; metabolism explained a minor proportion of the variation in development rates among species, and only after accounting for temperature effects. We discuss evidence that temperature further obscures the expected interspecific trade-off between development rate and offspring quality. These results demonstrate the importance of considering extrinsic inputs to trait expression and trade-offs across species.

  3. Ceftriaxone-induced immune hemolytic anemia as a life-threatening complication of antibiotic treatment of 'chronic Lyme disease'.

    Science.gov (United States)

    De Wilde, Maarten; Speeckaert, Marijn; Callens, Rutger; Van Biesen, Wim

    2017-04-01

    'Chronic Lyme disease' is a controversial condition. As any hard evidence is lacking that unresolved systemic symptoms, following an appropriately diagnosed and treated Lyme disease, are related to a chronic infection with the tick-borne spirochaetes of the Borrelia genus, the term 'chronic Lyme disease' should be avoided and replaced by the term 'post-treatment Lyme disease syndrome.' The improper prescription of prolonged antibiotic treatments for these patients can have an impact on the community antimicrobial resistance and on the consumption of health care resources. Moreover, these treatments can be accompanied by severe complications. In this case report, we describe a life-threatening ceftriaxone-induced immune hemolytic anemia with an acute kidney injury (RIFLE-stadium F) due to a pigment-induced nephropathy in a 76-year-old woman, who was diagnosed with a so-called 'chronic Lyme disease.'

  4. Tissue characteristics of high- and low-incidence plutonium-induced osteogenic sarcoma sites in life-span beagles

    International Nuclear Information System (INIS)

    Miller, S.C.; Jee, W.S.S.; Smith, J.M.; Wronski, T.J.

    1986-01-01

    On the basis of information gathered from the 239 Pu life-span study in beagles at the University of Utah, the tissue features were found to be characteristic of high-incidence bone-tumor sites compared to low-incidence sites included more hematopoietic tissues in the bone marrow; greater trabecular bone mass; greater bone remodeling rates; greater mineral apposition rates; greater density and activity of bone surface cells; greater density of putative bone-cell precursors; greater initial uptake of plutonium on bone surfaces; and greater marrow vascular volumes and a venous sinusoidal bed. Although most of these studies are not yet complete, the information being collected should contribute to our understanding of the mechanisms of radiation-induced osteogenic sarcomas. This should aid in predicting the types and characteristics of osseous tissues where radiation-induced osteogenic sarcomas may arise in humans. 25 refs., 4 figs., 3 tabs

  5. Photo-induced toxicity in early life stage fiddler crab (Uca longisignalis) following exposure to Deepwater Horizon oil.

    Science.gov (United States)

    Damare, Leigh M; Bridges, Kristin N; Alloy, Matthew M; Curran, Thomas E; Soulen, Brianne K; Forth, Heather P; Lay, Claire R; Morris, Jeffrey M; Stoeckel, James A; Roberts, Aaron P

    2018-05-01

    The 2010 explosion of the Deepwater Horizon (DWH) oil rig led to the release of millions of barrels of oil in the Gulf of Mexico. Oil in aquatic ecosystems exerts toxicity through multiple mechanisms, including photo-induced toxicity following co-exposure with UV radiation. The timing and location of the spill coincided with both fiddler crab reproduction and peak yearly UV intensities, putting early life stage fiddler crabs at risk of injury due to photo-induced toxicity. The present study assessed sensitivity of fiddler crab larvae to photo-induced toxicity during co-exposure to a range of environmentally relevant dilutions of high-energy water accommodated fractions of DWH oil, and either dark recovery period (duration: 17-h) in between. Survival was significantly decreased in treatments the presence of >10% UV and relatively low concentrations of oil. Results of the present study indicate fiddler crab larvae are sensitive to photo-induced toxicity in the presence of DWH oil. These results are of concern, as fiddler crabs play an important role as ecosystem engineers, modulating sediment biogeochemical processes via burrowing action. Furthermore, they occupy an important place in the food web in the Gulf of Mexico.

  6. Antistranspirant compounds alleviate the mild-desiccation-induced reduction of vase life in cut roses

    NARCIS (Netherlands)

    Fanourakis, D.; Gebraegziabher, Habtamu; Li, Tao; Kambourakis, Emmanouil; Ligoxigakis, Eleftherios K.; Padadimitriou, Michael; Strataridaki, Argiro; Bouranis, Dimitrios; Fiorani, F.; Heuvelink, E.; Ottosen, Carl-Otto

    2016-01-01

    The vase life sensitivity to mild desiccation (12% weight loss) was addressed in rose, together with alleviation possibilities. The postharvest longevity upon arrival or following mild desiccation was determined on eight cultivars, combined with several morpho-physiological traits. Mild desiccation

  7. Early life history and habitat ecology of estuarine fishes: responses to natural and human induced change

    Directory of Open Access Journals (Sweden)

    Kenneth Able

    2015-12-01

    Full Text Available Our understanding of the early life history of fishes and their habitats has proceeded from basic natural history to ecology, but we often need to return to natural history to address deficiencies in conceptual and quantitative models of ecosystems. This understanding is further limited by the complex life history of fishes and the lack of appreciation of shifting baselines in estuaries. These inadequacies are especially evident when we try to address the effects of human influences, e.g. fishing, urbanization, and climate change. Often our baselines are inadequate or inaccurate. Our work has detected these along the coasts of the U.S. in extensive time series of larval fish ingress into estuaries, studies of the effects of urbanization, and responses to catastrophes such as the BP oil spill. Long-term monitoring, especially, continues to provide critical insights

  8. Life Cycle Inventory Modelling of Land Use Induced by Crop Consumption

    DEFF Research Database (Denmark)

    Kløverpris, Jesper; Wenzel, Henrik; Nielsen, Per Henning

    2008-01-01

    The actual land use consequences of crop consumption are not very well reflected in existing life cycle inventories. The state of the art is that such inventories typically include data from crop production in the country in which the crop is produced, and consequently the inventories do...... establishment of a link between crop demand and technological development. Through this approach, life cycle inventories for crops reflecting the actual land use consequences of consumption can be established. Further work (based on the methodological framework in this study) will address the practical....... Based on the current market trend for crops and an analysis of basic mechanisms in crop production, concepts for modelling how crop consumption affects the global agricultural area and the intensity of crop production are suggested. It is demonstrated how the assumptions concerning drivers...

  9. Environmentally-induced plasticity of life history parameters in the cladoceran Simocephalus vetulus

    Czech Academy of Sciences Publication Activity Database

    Šorf, Michal; Cábová, M.; Rychtecký, Pavel

    2017-01-01

    Roč. 66, SEP 01 (2017), s. 40-43 ISSN 0075-9511 R&D Projects: GA ČR(CZ) GA14-29857S Institutional support: RVO:60077344 Keywords : cladocera * life history traits * feeding Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 1.427, year: 2016 http://www.sciencedirect.com/science/article/pii/S007595111630192X

  10. CHANGES IN MENTAL HEALTH AND SATISFACTION WITH LIFE DURING PHYSICAL INACTIVITY INDUCED BY BED REST EXPERIMENT

    Directory of Open Access Journals (Sweden)

    Tjaša Dimec Časar

    2016-01-01

    Full Text Available Simulated weightlessness by bed rest model represents an important method to study the consequences of physical inactivity and sedentarism on the human body. The purpose of the study was to examine the effects of prolonged physical inactivity on psychological distress, depressive symptoms and satisfaction with life of healthy male adults. Participants were ten volunteers, aged between 21 and 28 years who were subjected to a 35-day head-down bed rest. Psychological state of the participants was measured with the General Health Questionnaire (GHQ-12, the Center for Epidemiological Studies Depression Scale (CES-D, and the Satisfaction with Life Scale (SWLS. Participants completed psychological inventories before, during and after the experiment. The results revealed no significant differences in mental health and satisfaction with life of participants following the head-down bed rest, however there was a tendency towards an increase in neurotic and depressive symptoms at the end of the experiment. The obtained results are interpreted in the light of stimulative living conditions in which the experiment was carried out, as well as the amount and quality of social interactions during the period of extended physical inactivity.

  11. [Aging-induced differences in relationships between intelligence and self-assessment of quality of life].

    Science.gov (United States)

    Razumnikova, O M; Prokhorova, L V; Yashanina, A A

    2016-01-01

    Relationships between a self-assessment of quality of life and level of verbal, figurative and social intelligence in three age groups of students (middle age 63,9±5,8, 32±7,2, and 19,7±1,5 years; 90 % women) are studied. The group of elderly people differed from younger in low values of an integrated indicator physical health according to SF-36 questionnaire, especially - on scales physical and role functioning, and decreased figurative and social intelligence at relative constancy of verbal IQ. The different age-associated forms of interrelation of components of intelligence and quality of life are found: positive correlation between social intelligence and role functioning scores at senior persons; more numerous positive correlations between verbal and figurative intelligence and indicators of quality of life including integrated indicator of mental health in the thirty-year-old group; and positive correlation between verbal intelligence and values on a scale physical functioning, but negative correlations between figurative intelligence and role functioning and between social intelligence and an integrated indicator physical health for the twenty-year-old group. Therefore, continuous education and IQ increasing during professional activity and after retirement it is possible to consider as prognostic valuable factors of «successful» aging.

  12. Dietary consumption of monosodium L-glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster.

    Science.gov (United States)

    Abolaji, Amos O; Olaiya, Charles O; Oluwadahunsi, Oluwagbenga J; Farombi, Ebenezer O

    2017-04-01

    Adaptive response is the ability of an organism to better counterattack stress-induced damage in response to a number of different cytotoxic agents. Monosodium L-glutamate (MSG), the sodium salt of amino acid glutamate, is commonly used as a food additive. We investigated the effects of MSG on the life span and antioxidant response in Drosophila melanogaster (D. melanogaster). Both genders (1 to 3 days old) of flies were fed with diet containing MSG (0.1, 0.5, and 2.5-g/kg diet) for 5 days to assess selected antioxidant and oxidative stress markers, while flies for longevity were fed for lifetime. Thereafter, the longevity assay, hydrogen peroxide (H 2 O 2 ), and reactive oxygen and nitrogen species levels were determined. Also, catalase, glutathione S-transferase and acetylcholinesterase activities, and total thiol content were evaluated in the flies. We found that MSG reduced the life span of the flies by up to 23% after continuous exposure. Also, MSG increased reactive oxygen and nitrogen species and H 2 O 2 generations and total thiol content as well as the activities of catalase and glutathione S-transferase in D. melanogaster (P reduced life span of flies. This study may therefore have public health significance in humans, and thus, moderate consumption of MSG is advocated by the authors. Copyright © 2017 John Wiley & Sons, Ltd.

  13. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

    Science.gov (United States)

    Leclercq, Sophie; Mian, Firoz M.; Stanisz, Andrew M.; Bindels, Laure B.; Cambier, Emmanuel; Ben-Amram, Hila; Koren, Omry; Forsythe, Paul; Bienenstock, John

    2017-01-01

    There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics has long-term effects on brain neurochemistry and behaviour. Here we investigate whether low-dose penicillin in late pregnancy and early postnatal life induces long-term effects in the offspring of mice. We find that penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood–brain barrier integrity and alters behaviour. The antibiotic-treated mice exhibit impaired anxiety-like and social behaviours, and display aggression. Concurrent supplementation with Lactobacillus rhamnosus JB-1 prevents some of these alterations. These results warrant further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders, and the possible attenuation of these by beneficial bacteria. PMID:28375200

  14. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.

    Science.gov (United States)

    Soffritti, Morando; Belpoggi, Fiorella; Manservigi, Marco; Tibaldi, Eva; Lauriola, Michelina; Falcioni, Laura; Bua, Luciano

    2010-12-01

    Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life. The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice. Six groups of 62-122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0  ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined. APM in our experimental conditions induces in males a significant dose-related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000  ppm (P < 0.01) and 16,000  ppm (P < 0.05). Moreover, the results show a significant dose-related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000  ppm (P < 0.05). The results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197-1206, 2010. © 2010 Wiley-Liss, Inc.

  15. The potential role of diffusion-induced grain-boundary migration in extended life prediction

    International Nuclear Information System (INIS)

    Handwerker, C.A.; Blendell, J.E.; Interrante, C.G.; Ahn, T.M.

    1993-01-01

    The selection of materials that are suitable for various high-level waste-packaging designs must reflect the need to meet requirements for long-term performance in repository environments that change with time. With this in mind, we examine how grain boundaries in materials are induced to migrate as a result of solute diffusion even at low temperatures, how the composition of the matrix material is changed significantly by this diffusion-induced grain boundary migration (DIGM), and how the changing microstructures and compositions during DIGM lead to major changes in materials performance, such as corrosion or embrittlement. Methods are discussed for prediction of the long-term behavior of materials affected by DIGM

  16. External gamma irradiation-induced effects in early-life stages of zebrafish, Danio rerio

    International Nuclear Information System (INIS)

    Gagnaire, B.; Cavalié, I.; Pereira, S.; Floriani, M.; Dubourg, N.; Camilleri, V.; Adam-Guillermin, C.

    2015-01-01

    Highlights: • The present study aimed to evaluate the effects of gamma rays on zebrafish larvae. • Different techniques were used: gene expression, biochemistry, microscopy and macroscopical observations. • The results showed that gamma irradiation can alter embryo-larval development at several levels of organization. - Abstract: In the general context of validation of tools useful for the characterization of ecological risk linked to ionizing radiation, the effects of an external gamma irradiation were studied in zebrafish larvae irradiated for 96 h with two dose rates: 0.8 mGy/d, which is close to the level recommended to protect ecosystems from adverse effects of ionizing radiation (0.24 mGy/d) and a higher dose rate of 570 mGy/d. Several endpoints were investigated, such as mortality, hatching, and some parameters of embryo-larval development, immunotoxicity, apoptosis, genotoxicity, neurotoxicity and histological alterations. Results showed that an exposure to gamma rays induced an acceleration of hatching for both doses and a decrease of yolk bag diameter for the highest dose, which could indicate an increase of global metabolism. AChE activity decreased with the low dose rate of gamma irradiation and alterations were also shown in muscles of irradiated larvae. These results suggest that gamma irradiation can induce damages on larval neurotransmission, which could have repercussions on locomotion. DNA damages, basal ROS production and apoptosis were also induced by irradiation, while ROS stimulation index and EROD biotransformation activity were decreased and gene expression of acetylcholinesterase, choline acetyltransferase, cytochrome p450 and myeloperoxidase increased. These results showed that ionizing radiation induced an oxidative stress conducting to DNA damages. This study characterized further the modes of action of ionizing radiation in fish.

  17. External gamma irradiation-induced effects in early-life stages of zebrafish, Danio rerio

    Energy Technology Data Exchange (ETDEWEB)

    Gagnaire, B., E-mail: beatrice.gagnaire@irsn.fr [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Cavalié, I. [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Pereira, S. [Neolys Diagnostics, Lyon 69373 (France); Floriani, M.; Dubourg, N.; Camilleri, V.; Adam-Guillermin, C. [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France)

    2015-12-15

    Highlights: • The present study aimed to evaluate the effects of gamma rays on zebrafish larvae. • Different techniques were used: gene expression, biochemistry, microscopy and macroscopical observations. • The results showed that gamma irradiation can alter embryo-larval development at several levels of organization. - Abstract: In the general context of validation of tools useful for the characterization of ecological risk linked to ionizing radiation, the effects of an external gamma irradiation were studied in zebrafish larvae irradiated for 96 h with two dose rates: 0.8 mGy/d, which is close to the level recommended to protect ecosystems from adverse effects of ionizing radiation (0.24 mGy/d) and a higher dose rate of 570 mGy/d. Several endpoints were investigated, such as mortality, hatching, and some parameters of embryo-larval development, immunotoxicity, apoptosis, genotoxicity, neurotoxicity and histological alterations. Results showed that an exposure to gamma rays induced an acceleration of hatching for both doses and a decrease of yolk bag diameter for the highest dose, which could indicate an increase of global metabolism. AChE activity decreased with the low dose rate of gamma irradiation and alterations were also shown in muscles of irradiated larvae. These results suggest that gamma irradiation can induce damages on larval neurotransmission, which could have repercussions on locomotion. DNA damages, basal ROS production and apoptosis were also induced by irradiation, while ROS stimulation index and EROD biotransformation activity were decreased and gene expression of acetylcholinesterase, choline acetyltransferase, cytochrome p450 and myeloperoxidase increased. These results showed that ionizing radiation induced an oxidative stress conducting to DNA damages. This study characterized further the modes of action of ionizing radiation in fish.

  18. Fatigue failure by in-line flow-induced vibration and fatigue life evaluation

    International Nuclear Information System (INIS)

    Odahara, Satoru; Murakami, Yukitaka; Inoue, Masahiro; Sueoka, Atsuo

    2004-01-01

    The phenomenon of fatigue failure by the In-line flow-induced vibration was studied. A newly water-flow-induced vibration system was made and used to reproduce fatigue failure by flow-induced vibration. A medium carbon steel specimen was fixed to the experimental equipment. A small artificial hole was introduced onto the specimen surface. Fatigue crack initiated from the artificial hole. A small portable strain histogram recorder (Mini Rainflow Corder, MRC) developed in another project of the authors' team was used to acquire the service strain hisogram at a critical point of the specimen and to measure the variation of natural frequency. Cumulative fatigue damage D defined by the Modified Miner Rule was calculated by using the strain histogram at the initial stage of test. The value of D was almost unity in the case of In-line vibration, while the values of D in the case of the Cross-flow vibration ranged from 0.2 to 0.8. (author)

  19. Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood.

    Science.gov (United States)

    Dinel, A L; Rey, C; Baudry, C; Fressange-Mazda, C; Le Ruyet, P; Nadjar, A; Pallet, P; Joffre, C; Layé, S

    2016-10-01

    Polyunsaturated fatty acids (PUFAs) are essential fatty acids, which are critical for brain development and later life cognitive functions. The main brain PUFAs are docosahexaenoic acid (DHA) for the n-3 family and arachidonic acid (ARA) for the n-6 family, which are provided to the post-natal brain by breast milk or infant formula. Recently, the use of dairy lipids (DL) in replacement of vegetable lipids (VL) was revealed to potently promote the accretion of DHA in the developing brain. Brain DHA, in addition to be a key component of brain development, display potent anti-inflammatory activities, which protect the brain from adverse inflammatory events. In this work, we evaluated the protective effect of partial replacement of VL by DL, supplemented or not with DHA and ARA, on post-natal inflammation and its consequence on memory. Mice were fed with diets poor in vegetal n-3 PUFA (Def VL), balanced in vegetal n-3/n-6 PUFA (Bal VL), balanced in dairy lipids (Bal DL) or enriched in DHA and ARA (Supp VL; Supp DL) from the first day of gestation until adulthood. At post-natal day 14 (PND14), pups received a single administration of the endotoxin lipopolysaccharide (LPS) and brain cytokine expression, microglia phenotype and neurogenesis were measured. In a second set of experiments, memory and neurogenesis were measured at adulthood. Overall, our data showed that lipid quality of the diet modulates early life LPS effect on microglia phenotype, brain cytokine expression and neurogenesis at PND14 and memory at adulthood. In particular, Bal DL diet protects from the adverse effect of early life LPS exposure on PND14 neurogenesis and adult spatial memory. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span.

    Science.gov (United States)

    Bale, Laurie K; West, Sally A; Conover, Cheryl A

    2017-08-01

    Pregnancy-associated plasma protein-A (PAPP-A) knockout (KO) mice, generated through homologous recombination in embryonic stem cells, have a significantly increased lifespan compared to wild-type littermates. However, it is unknown whether this longevity advantage would pertain to PAPP-A gene deletion in adult animals. In the present study, we used tamoxifen (Tam)-inducible Cre recombinase-mediated excision of the floxed PAPP-A (fPAPP-A) gene in mice at 5 months of age. fPAPP-A mice, which were either positive (pos) or negative (neg) for Tam-Cre, received Tam treatment with quarterly boosters. Only female mice could be used with this experimental design. fPAPP-A/neg and fPAPP-A/pos mice had similar weights at the start of the experiment and showed equivalent weight gain. We found that fPAPP-A/pos mice had a significant extension of life span (P = 0.005). The median life span was increased by 21% for fPAPP-A/pos compared to fPAPP-A/neg mice. Analysis of mortality in life span quartiles indicated that the proportion of deaths of fPAPP-A/pos mice were lower than fPAPP-A/neg mice at young adult ages (P = 0.002 for 601-800 days) and higher than fPAPP-A/neg mice at older ages (P = 0.004 for >1000 days). Thus, survival curves and age-specific mortality indicate that female mice with knockdown of PAPP-A gene expression as adults have an extended healthy life span. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  1. Early Maternal Deprivation Enhances Voluntary Alcohol Intake Induced by Exposure to Stressful Events Later in Life

    Directory of Open Access Journals (Sweden)

    Sara Peñasco

    2015-01-01

    Full Text Available In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9, on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v was investigated using the two-bottle free choice paradigm. To better understand the relationship between stress and alcohol consumption, voluntary alcohol intake was also evaluated following additional stressful events later in life, that is, a week of alcohol cessation and a week of alcohol cessation combined with exposure to restraint stress. Female animals consumed more alcohol than males only after a second episode of alcohol cessation combined with restraint stress. MD did not affect baseline voluntary alcohol intake but increased voluntary alcohol intake after stress exposure, indicating that MD may render animals more vulnerable to the effects of stress on alcohol intake. During adolescence, when animals had free access to alcohol, MD animals showed lower body weight gain but a higher growth rate than control animals. Moreover, the higher growth rate was accompanied by a decrease in food intake, suggesting an altered metabolic regulation in MD animals that may interact with alcohol intake.

  2. Apoptosis-related genes induced in response to ketamine during early life stages of zebrafish.

    Science.gov (United States)

    Félix, Luís M; Serafim, Cindy; Valentim, Ana M; Antunes, Luís M; Matos, Manuela; Coimbra, Ana M

    2017-09-05

    Increasing evidence supports that ketamine, a widely used anaesthetic, potentiates apoptosis during development through the mitochondrial pathway of apoptosis. Defects in the apoptotic machinery can cause or contribute to the developmental abnormalities previously described in ketamine-exposed zebrafish. The involvement of the apoptotic machinery in ketamine-induced teratogenicity was addressed by assessing the apoptotic signals at 8 and 24 hpf following 20min exposure to ketamine at three stages of early zebrafish embryo development (256 cell, 50% epiboly and 1-4 somites stages). Exposure at the 256-cell stage to ketamine induced an up-regulation of casp8 and pcna at 8 hpf while changes in pcna at the mRNA level were observed at 24 hpf. After the 50% epiboly stage exposure, the mRNA levels of casp9 were increased at 8 and 24 hpf while aifm1 was affected at 24 hpf. Both tp53 and pcna expressions were increased at 8 hpf. After exposure during the 1-4 somites stage, no meaningful changes on transcript levels were observed. The distribution of apoptotic cells and the caspase-like enzymatic activities of caspase-3 and -9 were not affected by ketamine exposure. It is proposed that ketamine exposure at the 256-cell stage induced a cooperative mechanism between proliferation and cellular death while following exposure at the 50% epiboly, a p53-dependent and -independent caspase activation may occur. Finally, at the 1-4 somites stage, the defence mechanisms are already fully in place to protect against ketamine-insult. Thus, ketamine teratogenicity seems to be dependent on the functional mechanisms present in each developmental stage. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders.

    Science.gov (United States)

    Carlson, Michelle J; Moore, Carolyn E; Tsai, Cynthia M; Shulman, Robert J; Chumpitazi, Bruno P

    2014-03-01

    It is unknown whether children with functional gastrointestinal (GI) disorders identify specific foods that exacerbate their GI symptoms. The objectives of this study were to determine the perceived role of food on GI symptoms and to determine the impact of food-induced symptoms on quality of life (QOL) in children with functional GI disorders. Between August and November 2010, 25 children ages 11 to 17 years old with functional GI disorders and a parent completed a food symptom association questionnaire and validated questionnaires assessing FGID symptoms and QOL. In addition, children completed a 24-hour food recall, participated in focus groups to identify problematic foods and any coping strategies, and discussed how their QOL was affected. Statistical analyses were conducted using χ2, t test, Mann-Whitney U test, Wilcoxon signed rank, and Spearman's ρ. Children identified a median of 11 (range=2 to 25) foods as exacerbating a GI symptom, with the most commonly identified foods being spicy foods, cow's milk, and pizza. Several coping strategies were identified, including consuming smaller portions, modifying foods, and avoiding a median of 8 (range=1 to 20) foods. Children reported that food-induced symptoms interfered with school performance, sports, and social activities. Although the parent's assessment of their child's QOL negatively correlated with the number of perceived symptom-inducing foods in their child, this relationship was not found in the children. Findings suggest that specific foods are perceived to exacerbate GI symptoms in children with functional GI disorders. In addition, despite use of several coping strategies, food-induced symptoms can adversely impact children's QOL in several important areas. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  4. Docetaxel induced Lyell′s syndrome: A rare life threatening cause of dermatitis medicamentosas

    Directory of Open Access Journals (Sweden)

    Faheem Arshad

    2014-01-01

    Full Text Available Lyell′s syndrome or toxic epidermal necrolysis (TEN is a life threatening complication mostly caused by medications, characterized by desquamative lesions of the skin and mucous membranes with 30 percent or more epidermal involvement along with mucus membrane. We report a rare case of toxic epidermal necrolysis following administration of docetaxel, a semi-synthetic taxane. A female diagnosed as having metastatic breast carcinoma received chemotherapy in form of docetaxel after being exposed to adjuvant chemotherapy, developed severe involvement of skin and mucus membrane. Diagnosis of TEN was made and she was managed with steroids, antibiotics, intravenous fluids and antiseptic dressings. Common toxicities reported with this drug include myelosuppression, alopecia, nail damage, erythema multiforme major and neuropathy. We believe this is the first case report of Lyell′s syndrome following docetaxel. Main aim of this case is to make physicians aware of the severe skin reactions with docetaxel, measures to avoid them, early recognition and prompt treatment.

  5. Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells

    Directory of Open Access Journals (Sweden)

    Brand Joseph

    2010-06-01

    Full Text Available Abstract Background The mammalian taste bud, a complex collection of taste sensory cells, supporting cells, and immature basal cells, is the structural unit for detecting taste stimuli in the oral cavity. Even though the cells of the taste bud undergo constant turnover, the structural homeostasis of the bud is maintained by balancing cell proliferation and cell death. Compared with nongustatory lingual epithelial cells, taste cells express higher levels of several inflammatory receptors and signalling proteins. Whether inflammation, an underlying condition in some diseases associated with taste disorders, interferes with taste cell renewal and turnover is unknown. Here we report the effects of lipopolysaccharide (LPS-induced inflammation on taste progenitor cell proliferation and taste bud cell turnover in mouse taste tissues. Results Intraperitoneal injection of LPS rapidly induced expression of several inflammatory cytokines, including tumor necrosis factor (TNF-α, interferon (IFN-γ, and interleukin (IL-6, in mouse circumvallate and foliate papillae. TNF-α and IFN-γ immunoreactivities were preferentially localized to subsets of cells in taste buds. LPS-induced inflammation significantly reduced the number of 5-bromo-2'-deoxyuridine (BrdU-labeled newborn taste bud cells 1-3 days after LPS injection, suggesting an inhibition of taste bud cell renewal. BrdU pulse-chase experiments showed that BrdU-labeled taste cells had a shorter average life span in LPS-treated mice than in controls. To investigate whether LPS inhibits taste cell renewal by suppressing taste progenitor cell proliferation, we studied the expression of Ki67, a cell proliferation marker. Quantitative real-time RT-PCR revealed that LPS markedly reduced Ki67 mRNA levels in circumvallate and foliate epithelia. Immunofluorescent staining using anti-Ki67 antibodies showed that LPS decreased the number of Ki67-positive cells in the basal regions surrounding circumvallate taste buds

  6. Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells.

    Science.gov (United States)

    Cohn, Zachary J; Kim, Agnes; Huang, Liquan; Brand, Joseph; Wang, Hong

    2010-06-10

    The mammalian taste bud, a complex collection of taste sensory cells, supporting cells, and immature basal cells, is the structural unit for detecting taste stimuli in the oral cavity. Even though the cells of the taste bud undergo constant turnover, the structural homeostasis of the bud is maintained by balancing cell proliferation and cell death. Compared with nongustatory lingual epithelial cells, taste cells express higher levels of several inflammatory receptors and signalling proteins. Whether inflammation, an underlying condition in some diseases associated with taste disorders, interferes with taste cell renewal and turnover is unknown. Here we report the effects of lipopolysaccharide (LPS)-induced inflammation on taste progenitor cell proliferation and taste bud cell turnover in mouse taste tissues. Intraperitoneal injection of LPS rapidly induced expression of several inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-6, in mouse circumvallate and foliate papillae. TNF-alpha and IFN-gamma immunoreactivities were preferentially localized to subsets of cells in taste buds. LPS-induced inflammation significantly reduced the number of 5-bromo-2'-deoxyuridine (BrdU)-labeled newborn taste bud cells 1-3 days after LPS injection, suggesting an inhibition of taste bud cell renewal. BrdU pulse-chase experiments showed that BrdU-labeled taste cells had a shorter average life span in LPS-treated mice than in controls. To investigate whether LPS inhibits taste cell renewal by suppressing taste progenitor cell proliferation, we studied the expression of Ki67, a cell proliferation marker. Quantitative real-time RT-PCR revealed that LPS markedly reduced Ki67 mRNA levels in circumvallate and foliate epithelia. Immunofluorescent staining using anti-Ki67 antibodies showed that LPS decreased the number of Ki67-positive cells in the basal regions surrounding circumvallate taste buds, the niche for taste progenitor

  7. Life cycle energy and greenhouse gas emission effects of biodiesel in the United States with induced land use change impacts

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Rui; Qin, Zhangcai; Han, Jeongwoo; Wang, Michael; Taheripour, Farzad; Tyner, Wallace; O' Connor, Don; Duffield, James

    2018-03-01

    This study conducted the updated simulations to depict a life cycle analysis (LCA) of the biodiesel production from soybeans and other feedstocks in the U.S. It addressed in details the interaction between LCA and induced land use change (ILUC) for biodiesel. Relative to the conventional petroleum diesel, soy biodiesel could achieve 76% reduction in GHG emissions without considering ILUC, or 66-72% reduction in overall GHG emissions when various ILUC cases were considered. Soy biodiesel’s fossil fuel consumption rate was also 80% lower than its petroleum counterpart. Furthermore, this study examined the cause and the implication of each key parameter affecting biodiesel LCA results using a sensitivity analysis, which identified the hot spots for fossil fuel consumption and GHG emissions of biodiesel so that future efforts can be made accordingly. Finally, biodiesel produced from other feedstocks (canola oil and tallow) were also investigated to contrast with soy biodiesel and petroleum diesel

  8. Climate-induced trends in predator–prey synchrony differ across life-history stages of an anadromous salmonid

    Science.gov (United States)

    Bell, Donovan A.; Kovach, Ryan; Vulstek, Scott C.; Joyce, John E.; Tallmon, David A.

    2017-01-01

    Differential climate-induced shifts in phenology can create mismatches between predators and prey, but few studies have examined predator–prey mismatch across multiple life-history stages. We used long-term data from a warming stream with shifting salmonid migration timings to quantify intra-annual migration synchrony between predatory Dolly Varden (Salvelinus malma) and Pacific salmon prey and examined how predator–prey synchrony has been influenced by climate change. We demonstrate that Dolly Varden have become increasingly mismatched with spring downstream migrations of abundant pink salmon (Oncorhynchus gorbuscha) juveniles. However, Dolly Varden have remained matched with fall upstream migrations of spawning Pacific salmon, including coho (Oncorhynchus kisutch), sockeye (Oncorhynchus nerka), and pink salmon. Downstream predator–prey migration synchrony decreased over time and with higher temperatures, particularly with pink salmon. In contrast, upstream migration synchrony was temporally stable and increased with rising temperatures. Differing trends in Dolly Varden predator–prey synchrony may be explained by the direct use of salmon to cue upstream migration, but not downstream migration. Overall, we show that climate change can have differing impacts on predator–prey synchrony across life-history stages.

  9. Application of microbeam in bio-science and life science. Biological effects induced in bystander cells by particle microbeams

    International Nuclear Information System (INIS)

    Suzuki, Masao

    2006-01-01

    Biological events occurring in cells directly hit by radiation appear in bystander cells nearby not hit directly, which is called the bystander effect. This review describes the events and mechanisms of biological bystander effect yielded by the low-dose radiation including the microbeam. Bystander effects, particularly by charged particle beams, have been studied by two representative approaches by α-ray from plutonium (stochastic irradiation) and by particle microbeams (targeted irradiation), where a bystander effect like chromosome aberrations is shown to occur by communication between irradiated and non-irradiated cells through gap junction. Bystander effects that do not require the cell contact also occur in the irradiated cell-conditioned medium (ICCM), where, not only the short-life radicals like reactive oxygen species and NO, but also more long-life factors participate. Authors have shown the presence of such bystander-inducing factors in ICCM, producing the aberrations even 48 hr after irradiation of either low or high linear energy transfer (LET) radiation. Bystander effects can be important from the aspect of risk assessments of radiation in the terrestrial/spatial environment involving aircraft as well as in cancer therapy by low-dose heavy particle beams. (T.I)

  10. Life cycle stage and water depth affect flooding-induced adventitious root formation in the terrestrial species Solanum dulcamara.

    Science.gov (United States)

    Zhang, Qian; Visser, Eric J W; de Kroon, Hans; Huber, Heidrun

    2015-08-01

    Flooding can occur at any stage of the life cycle of a plant, but often adaptive responses of plants are only studied at a single developmental stage. It may be anticipated that juvenile plants may respond differently from mature plants, as the amount of stored resources may differ and morphological changes can be constrained. Moreover, different water depths may require different strategies to cope with the flooding stress, the expression of which may also depend on developmental stage. This study investigated whether flooding-induced adventitious root formation and plant growth were affected by flooding depth in Solanum dulcamara plants at different developmental stages. Juvenile plants without pre-formed adventitious root primordia and mature plants with primordia were subjected to shallow flooding or deep flooding for 5 weeks. Plant growth and the timing of adventitious root formation were monitored during the flooding treatments. Adventitious root formation in response to shallow flooding was significantly constrained in juvenile S. dulcamara plants compared with mature plants, and was delayed by deep flooding compared with shallow flooding. Complete submergence suppressed adventitious root formation until up to 2 weeks after shoots restored contact with the atmosphere. Independent of developmental stage, a strong positive correlation was found between adventitious root formation and total biomass accumulation during shallow flooding. The potential to deploy an escape strategy (i.e. adventitious root formation) may change throughout a plant's life cycle, and is largely dependent on flooding depth. Adaptive responses at a given stage of the life cycle thus do not necessarily predict how the plant responds to flooding in another growth stage. As variation in adventitious root formation also correlates with finally attained biomass, this variation may form the basis for variation in resistance to shallow flooding among plants. © The Author 2015. Published by

  11. β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.

    Science.gov (United States)

    Zhou, Xianchong; Escala, Wilfredo; Papapetropoulos, Spyridon; Zhai, R Grace

    2010-11-01

    The neurotoxic non-protein amino acid, β-N-methylamino-L-alanine (BMAA), was first associated with the high incidence of Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) in Guam. Recently, BMAA has been implicated as a fierce environmental factor that contributes to the etiology of Alzheimer's and Parkinson's diseases, in addition to ALS. However, the toxicity of BMAA in vivo has not been clearly demonstrated. Here we report our investigation of the neurotoxicity of BMAA in Drosophila. We found that dietary intake of BMAA reduced life span, locomotor functions, and learning and memory abilities in flies. The severity of the alterations in phenotype is correlated with the concentration of BMAA detected in flies. Interestingly, developmental exposure to BMAA had limited impact on survival rate, but reduced fertility in females, and caused delayed neurological impairment in aged adults. Our studies indicate that BMAA exposure causes chronic neurotoxicity, and that Drosophila serves as a useful model in dissecting the pathogenesis of ALS/PDC.

  12. Energy dependence of average half-life of delayed neutron precursors in fast neutron induced fission of 235U and 236U

    International Nuclear Information System (INIS)

    Isaev, S.G.; Piksaikin, L.E.; Kazakov, L.E.; Tarasko, M.Z.

    2000-01-01

    The measurements of relative abundances and periods of delayed neutrons from fast neutron induced fission of 235 U and 236 U have been made at the electrostatic accelerator CG-2.5 at IPPE. The preliminary results were obtained and discussed in the frame of the systematics of the average half-life of delayed neutron precursors. It was shown that the average half-life value in both reactions depends on the energy of primary neutrons [ru

  13. Influence of age, sex and life style factors (smoking habits) on the spontaneous and radiation induced micronuclei frequencies

    International Nuclear Information System (INIS)

    Di Giorgio, M.; Nasazzi, N.; Heredia, M.L.

    1995-01-01

    Several endpoints have been used for monitoring human populations for environmental or occupational exposure to genotoxic agents, particularly ionizing radiation. The cytokinesis-block micronucleus (MN) assay in peripheral lymphocytes is a reliable method for assessing radiation induced chromosomal damage (DNA breaks and mitotic spindle disturbances) and thus, a suitable dosimeter for estimating in vivo whole body exposures. To further define the use of this assay in Biological Dosimetry, a study to determine the influence of age, sex and life style factors (smoking habit) on the spontaneous and radiation induced MN frequencies was performed. The estimation of MN frequencies was analyzed in lymphocytes cultures from 50 healthy donors aged between 4 and 62 years. On the basis of their smoking habit they were divided into 2 groups. A fraction of the sample was irradiated in vitro with γ rays in the range of 0.35 Gy to 4 Gy. A statistically significant influence on the spontaneous MN frequency was observed (R 2 = 0.59) when the variables age and smoking habit were analyzed and also a statistically significant influence on the radiation induced MN frequency was obtained (R 2 = 0.86) when dose, age and smoking habit were studied. Sex did not influence MN variability significantly but there was a greater dispersion in the results for females when compared to males, possibly due to the loss of X chromosomes. The comparison of the data from smoking donors to non smoking donors supports the convenience of taking into account the smoking habit for estimating in vivo whole body exposure to γ rays for doses below 2 Gy. (author). 8 refs., 3 figs., 1 tab

  14. Impact of chemotherapy-induced neutropenia on quality of life: a prospective pilot investigation.

    Science.gov (United States)

    Fortner, Barry V; Schwartzberg, Lee; Tauer, Kurt; Houts, Arthur C; Hackett, James; Stolshek, Brad S

    2005-07-01

    In this exploratory, prospective study evaluated quality of life (QoL) changes in patients with diverse cancers during the first cycle of myelosuppressive chemotherapy. Of 80 patients enrolled, 71 were observed during one of five chemotherapy regimens: docetaxel; CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone); carboplatin-paclitaxel; carboplatin-docetaxel; and carboplatin-gemcitabine. Complete blood counts were taken weekly. QoL and symptom burden measures were administered at baseline and throughout the cycle, and included SF-36, Cancer Care Monitor (CCM), Hospital Anxiety and Depression Scale (HADS), and Psychosocial Adjustment to Illness Scale (PAIS). Using generalized estimating equations, we modeled the change in each measure from baseline to the end of each week using the following covariates: baseline QoL measure, baseline SF-36 Physical and Mental Health Summary scores, sex, age, cycle week, grade 4 neutropenia any time in the past 7 days (yes/no), and the interaction of the latter two covariates. Of the 71 patients observed, 33 developed grade 4 neutropenia during the first 2 weeks. Changes from baseline in SF-36 Bodily Pain, HADS Anxiety, and PAIS Social Environment scores were significantly less favorable (P<0.05) when patients experienced grade 4 neutropenia any time in the past 7 days compared to when they did not (grade 0-3). A similar, but non-significant, trend was also observed for 12 other QoL measures. QoL may be adversely affected up to 7 days after patients experience grade 4 (versus grade 0-3) neutropenia. Such findings need to be examined further in studies with adequate statistical power to test a priori hypotheses regarding specific QoL measures.

  15. Chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer survivors : Results from the population-based PROFILES registry

    NARCIS (Netherlands)

    Ezendam, N.P.M.; Pijlman, B.M.; Bhugwandass, C.; Pruijt, J.F.; Mols, F.; Vos, M.C.; Pijnenborg, J.M.; van de Poll-Franse, L.

    2014-01-01

    Objective This study assessed the prevalence and risk factors of chemotherapy-induced peripheral neuropathy, and its impact on health-related quality of life among ovarian cancer survivors, 2–12 years after diagnosis. Methods Women (n = 348) diagnosed with ovarian cancer between 2000 and 2010, as

  16. Azadirachtin-induced effects on various life history traits and cellular immune reactions of Galleria mellonella (Lepidoptera: Pyralidae

    Directory of Open Access Journals (Sweden)

    Er Aylin

    2017-01-01

    Full Text Available The effects of the botanical insecticide azadirachtin were examined on the life history traits, fecundity and immune parameters of Galleria mellonella L. (Lepidoptera: Pyralidae. We determined that for the topical application of azadirachtin, the LC50 was 16.564 ppm; at 100 ppm the adult emergence time was prolonged, however the longevity of adults remained unchanged above sublethal concentrations. The mean number of healthy eggs and the fecundity of adults decreased, whereas the number of defective eggs increased with azadirachtin treatment. At concentrations >50 ppm female G. mellonella adults laid no eggs. Azadirachtin reduced total hemocyte counts at 24 and 48 h posttreatment, however the alterations in differential hemocyte counts were only significant at 100 ppm. Laminarin-induced nodulation response and the spreading ability of hemocytes were also suppressed with azadirachtin treatment. Our results suggest that azadirachtin, as a good candidate for integrated pest control, has the capability to affect the biological parameters and cellular immunity of the model insect G. mellonella.

  17. Impact of Radiation-Induced Xerostomia on Quality of Life After Primary Radiotherapy Among Patients With Head and Neck Cancer

    International Nuclear Information System (INIS)

    Jellema, Anke Petra; Slotman, Ben J.; Doornaert, Patricia; Leemans, C. Rene M.D.; Langendijk, Johannes A.

    2007-01-01

    Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among head and neck cancer patients treated with primary radiotherapy. Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included. Late xerostomia according to the Radiation Therapy Oncology Group (RTOG-xerostomia) and QoL (European Organization for Research and Treatment of Cancer QLC-C30) were assessed at baseline and every 6th month from 6 months to 24 months after radiotherapy. Results: A significant association was found between RTOG-xerostomia and overall QoL outcome (effect size [ES] 0.07, p 65 years). An analysis of the impact of RTOG-xerostomia on overall QoL outcome over time showed an increase from 0.09 at 6 months to 0.22 at 24 months. With elapsing time, a worsening was found for these individual scales with increasing RTOG-xerostomia. Conclusions: The results of this prospective study are the first to show a significant impact of radiation-induced xerostomia on QoL. Although the incidence of Grade ≥2 RTOG-xerostomia decreases with time, its impact on QoL increases. This finding emphasizes the importance of prevention of xerostomia

  18. Life cycle energy and greenhouse gas emission effects of biodiesel in the United States with induced land use change impacts.

    Science.gov (United States)

    Chen, Rui; Qin, Zhangcai; Han, Jeongwoo; Wang, Michael; Taheripour, Farzad; Tyner, Wallace; O'Connor, Don; Duffield, James

    2018-03-01

    This study conducted the updated simulations to depict a life cycle analysis (LCA) of the biodiesel production from soybeans and other feedstocks in the U.S. It addressed in details the interaction between LCA and induced land use change (ILUC) for biodiesel. Relative to the conventional petroleum diesel, soy biodiesel could achieve 76% reduction in GHG emissions without considering ILUC, or 66-72% reduction in overall GHG emissions when various ILUC cases were considered. Soy biodiesel's fossil fuel consumption rate was also 80% lower than its petroleum counterpart. Furthermore, this study examined the cause and the implication of each key parameter affecting biodiesel LCA results using a sensitivity analysis, which identified the hot spots for fossil fuel consumption and GHG emissions of biodiesel so that future efforts can be made accordingly. Finally, biodiesel produced from other feedstocks (canola oil and tallow) were also investigated to contrast with soy biodiesel and petroleum diesel. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  19. Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.

    Science.gov (United States)

    Murphy, Margaret O; Herald, Joseph B; Wills, Caleb T; Unfried, Stanley G; Cohn, Dianne M; Loria, Analia S

    2017-02-01

    Experimental studies in rodents have shown that females are more susceptible to exhibiting fat expansion and metabolic disease compared with males in several models of fetal programming. This study tested the hypothesis that female rat pups exposed to maternal separation (MatSep), a model of early-life stress, display an exacerbated response to diet-induced obesity compared with male rats. Also, we tested whether the postnatal treatment with metyrapone (MTP), a corticosterone synthase inhibitor, would attenuate this phenotype. MatSep was performed in WKY offspring by separation from the dam (3 h/day, postnatal days 2-14). Upon weaning, male and female rats were placed on a normal (ND; 18% kcal fat) or high-fat diet (HFD; 60% kcal fat). Nondisturbed littermates served as controls. In male rats, no diet-induced differences in body weight (BW), glucose tolerance, and fat tissue weight and morphology were found between MatSep and control male rats. However, female MatSep rats displayed increased BW gain, fat pad weights, and glucose intolerance compared with control rats (P obesity risk factors, including elevated adiposity, hyperleptinemia, and glucose intolerance. These findings show that exposure to stress hormones during early life could be a key event to enhance diet-induced obesity and metabolic disease in female rats. Thus, pharmacological and/or behavioral inflection of the stress levels is a potential therapeutic approach for prevention of early life stress-enhanced obesity and metabolic disease. Copyright © 2017 the American Physiological Society.

  20. COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.

    Science.gov (United States)

    Henquet, C; Rosa, A; Delespaul, P; Papiol, S; Fananás, L; van Os, J; Myin-Germeys, I

    2009-02-01

    A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25). Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability. The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.

  1. Hemoglobin levels and quality of life in patients with symptomatic chemotherapy-induced anemia: the eAQUA study

    Directory of Open Access Journals (Sweden)

    Mouysset JL

    2016-01-01

    Full Text Available Jean-Loup Mouysset,1 Beata Freier,2 Joan van den Bosch,3 Charles Briac Levaché,4 Alain Bols,5 Hans Werner Tessen,6 Laura Belton,7 G Chet Bohac,8 Jan-Henrik Terwey,9 Giuseppe Tonini101Department of Medical Oncology, Clinique Rambot Provencale, Aix en Provence, France; 2Clinical Oncology, Wojewodzki Szpital Specjalistyczny, Wroclaw, Poland; 3Department of Internal Medicine/Oncology, Albert Schweitzer Ziekenhuis locatie Dordwijk, Dordrecht, the Netherlands; 4Radiotherapy Service, Medical Oncology, Polyclinique Francheville, Périgueux, France; 5Central Pharmacy, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium; 6Private Oncology Practice. Goslar, Germany; 7LB Biostatistics, London, UK; 8Clinical Research, Amgen Inc., Thousand Oaks, CA, USA; 9Medical Development – Oncology, Amgen (Europe GmbH, Zug, Switzerland; 10Department of Medical Oncology, Università Campus Bio-Medico, Roma, ItalyPurpose: To assess hemoglobin (Hb outcomes and fatigue-related quality-of-life (QoL (electronic assessment in patients with solid tumors and symptomatic chemotherapy-induced anemia receiving cytotoxic chemotherapy and darbepoetin alfa (DA or another erythropoiesis-stimulating agent according to European indication.Methods: eAQUA was a Phase IV prospective observational study. The primary outcome (assessed in the primary analysis set [PAS]: patients receiving one or more DA dose who had baseline and week 9 assessments for Hb and QoL was the proportion of patients receiving DA having both Hb increases ≥1 g/dL and improved QoL between baseline and week 9. Functional Assessment of Cancer Therapy-Fatigue (FACT-F subscale scores were anchored to fatigue visual analog scale scores to determine the minimally important difference for improved QoL. Overall data/data over time are reported for the full analysis set (patients receiving one or more erythropoiesis-stimulating agent dose, n=1,158; week 9 data (ie, data relating to the primary and secondary outcomes are reported

  2. Exercise-Induced Anaphylaxis: A Case Report and Review of the Diagnosis and Treatment of a Rare but Potentially Life-Threatening Syndrome

    Directory of Open Access Journals (Sweden)

    Nathan T. Jaqua

    2013-01-01

    Full Text Available A 24-year-old male Marine with an uncomplicated medical history and a long history of strenuous, daily exercise presented to the emergency department after experiencing anaphylactic shock while running. Symptoms resolved following administration of intramuscular diphenhydramine, ranitidine, intravenous methylprednisolone, and intravenous fluids. On followup in the allergy clinic, a meticulous clinical history was obtained which elucidated a picture consistent with exercise-induced anaphylaxis. He had experienced diffuse pruritus and urticaria while exercising on multiple occasions over the last three years. His symptoms would usually increase as exercise continued. Prior to the first episode, he regularly exercised without symptoms. Exercise-induced anaphylaxis is a rare but potentially life-threatening syndrome that requires a careful clinical history and is a diagnosis of exclusion. Treatment is primarily exercise avoidance. Prophylactic mediations are inconsistently effective but are empirically used. Successful treatment with omalizumab was recently reported in a case of refractory exercise-induced anaphylaxis.

  3. Early-Life Experience Decreases Drug-Induced Reinstatement of Morphine CPP in Adulthood via Microglial-Specific Epigenetic Programming of Anti-Inflammatory IL-10 Expression

    Science.gov (United States)

    Schwarz, Jaclyn M.; Hutchinson, Mark R.; Bilbo, Staci D.

    2012-01-01

    A critical component of drug addiction research involves identifying novel biological mechanisms and environmental predictors of risk or resilience to drug addiction and associated relapse. Increasing evidence suggests microglia and astrocytes can profoundly affect the physiological and addictive properties of drugs of abuse, including morphine. We report that glia within the rat Nucleus Accumbens (NAcc) respond to morphine with an increase in cytokine/chemokine expression, which predicts future reinstatement of morphine conditioned place preference (CPP) following a priming dose of morphine. This glial response to morphine is influenced by early-life experience. A neonatal handling paradigm that increases the quantity and quality of maternal care significantly increases baseline expression of the anti-inflammatory cytokine IL-10 within the NAcc, attenuates morphine-induced glial activation, and prevents the subsequent reinstatement of morphine CPP in adulthood. IL-10 expression within the NAcc and reinstatement of CPP are negatively correlated, suggesting a protective role for this specific cytokine against morphine-induced glial reactivity and drug-induced reinstatement of morphine CPP. Neonatal handling programs the expression of IL-10 within the NAcc early in development, and this is maintained into adulthood via decreased methylation of the IL-10 gene specifically within microglia. The effect of neonatal handling is mimicked by pharmacological modulation of glia in adulthood with Ibudilast, which increases IL-10 expression, inhibits morphine-induced glial activation within the NAcc, and prevents reinstatement of morphine CPP. Taken together, we have identified a novel gene X early-life environment interaction on morphine-induced glial activation, and a specific role for glial activation in drug-induced reinstatement of drug-seeking behavior. PMID:22159099

  4. Early life hormetic treatments decrease irradiation-induced oxidative damage, increase longevity, and enhance sexual performance during old age in the Caribbean fruit fly

    International Nuclear Information System (INIS)

    López-Martínez, Giancarlo; Hahn, Daniel A.

    2014-01-01

    Early life events can have dramatic consequences on performance later in life. Exposure to stressors at a young age affects development, the rate of aging, risk of disease, and overall lifespan. In spite of this, mild stress exposure early in life can have beneficial effects on performance later in life. These positive effects of mild stress are referred to as physiological conditioning hormesis. In our current study we used anoxia conditioning hormesis as a pretreatment to reduce oxidative stress and improve organismal performance, lifespan, and healthspan of Caribbean fruit flies. We used gamma irradiation to induce mild oxidative damage in a low-dose experiment, and massive oxidative damage in a separate high-dose experiment, in pharate adult fruit flies just prior to adult emergence. Irradiation-induced oxidative stress leads to reduced adult emergence, flight ability, mating performance, and lifespan. We used a hormetic approach, one hour of exposure to anoxia plus irradiation in anoxia, to lower post-irradiation oxidative damage. We have previously shown that this anoxic-conditioning treatment elevates total antioxidant capacity and lowers post-irradiation oxidative damage to lipids and proteins. In this study, conditioned flies had lower mortality rates and longer lifespan compared to those irradiated without hormetic conditioning. As a metric of healthspan, we tracked mating both at a young age (10 d) and old age (30 d). We found that anoxia-conditioned male flies were more competitive at young ages when compared to unconditioned irradiation stressed male flies, and that the positive effects of anoxic conditioning hormesis on mating success were even more pronounced in older males. Our data shows that physiological conditioning hormesis at a young age, not only improves immediate metrics of organismal performance (emergence, flight, mating), but the beneficial effects also carry into old age by reducing late life oxidative damage and improving lifespan and

  5. Spoilage of Microfiltered and Pasteurized Extended Shelf Life Milk Is Mainly Induced by Psychrotolerant Spore-Forming Bacteria that often Originate from Recontamination.

    Science.gov (United States)

    Doll, Etienne V; Scherer, Siegfried; Wenning, Mareike

    2017-01-01

    Premature spoilage and varying product quality due to microbial contamination still constitute major problems in the production of microfiltered and pasteurized extended shelf life (ESL) milk. Spoilage-associated bacteria may enter the product either as part of the raw milk microbiota or as recontaminants in the dairy plant. To identify spoilage-inducing bacteria and their routes of entry, we analyzed end products for their predominant microbiota as well as the prevalence and biodiversity of psychrotolerant spores in bulk tank milk. Process analyses were performed to determine the removal of psychrotolerant spores at each production step. To detect transmission and recontamination events, strain typing was conducted with isolates obtained from all process stages. Microbial counts in 287 ESL milk packages at the end of shelf life were highly diverse ranging from shelf life is influenced only to a minor extent by raw-milk-associated factors. In contrast, recontamination with spores, particularly from the B. cereus complex, seems to occur. To enhance milk quality throughout the entire shelf life, improved plant sanitation and disinfection that target the elimination of spores are necessary.

  6. Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model.

    Science.gov (United States)

    Bock, J; Breuer, S; Poeggel, G; Braun, K

    2017-03-01

    In a novel animal model Octodon degus we tested the hypothesis that, in addition to genetic predisposition, early life stress (ELS) contributes to the etiology of attention-deficit hyperactivity disorder-like behavioral symptoms and the associated brain functional deficits. Since previous neurochemical observations revealed that early life stress impairs dopaminergic functions, we predicted that these symptoms can be normalized by treatment with methylphenidate. In line with our hypothesis, the behavioral analysis revealed that repeated ELS induced locomotor hyperactivity and reduced attention towards an emotionally relevant acoustic stimulus. Functional imaging using ( 14 C)-2-fluoro-deoxyglucose-autoradiography revealed that the behavioral symptoms are paralleled by metabolic hypoactivity of prefrontal, mesolimbic and subcortical brain areas. Finally, the pharmacological intervention provided further evidence that the behavioral and metabolic dysfunctions are due to impaired dopaminergic neurotransmission. Elevating dopamine in ELS animals by methylphenidate normalized locomotor hyperactivity and attention-deficit and ameliorated brain metabolic hypoactivity in a dose-dependent manner.

  7. Life Estimation of PWR Steam Generator U-Tubes Subjected to Foreign Object-Induced Fretting Wear

    International Nuclear Information System (INIS)

    Jo, Jong Chull; Jhung, Myung Jo; Kim, Woong Sik; Kim, Hho Jung

    2005-01-01

    This paper presents an approach to the remaining life prediction of steam generator (SG) U-tubes, which are intact initially, subjected to fretting-wear degradation due to the interaction between a vibrating tube and a foreign object in operating nuclear power plants. The operating SG shell-side flow field conditions are obtained from a three-dimensional SG flow calculation using the ATHOS3 code. Modal analyses are performed for the finite element models of U-tubes to get the natural frequency, corresponding mode shape, and participation factor. The wear rate of a U-tube caused by a foreign object is calculated using the Archard formula, and the remaining life of the tube is predicted. Also discussed in this study are the effects of the tube modal characteristics, external flow velocity, and tube internal pressure on the estimated results of the remaining life of the tube

  8. Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer

    NARCIS (Netherlands)

    Jellema, Anke Petra; Slotman, Ben J.; Doornaert, Patricia; Leemans, C. Rene; Langendijk, Johannes A.

    2007-01-01

    Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among bead and neck cancer patients treated with primary radiotherapy. Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included.

  9. Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper

    DEFF Research Database (Denmark)

    Jensen, Trine Hammer; Nielsen, Line; Aasted, Bent

    2009-01-01

    Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres...

  10. Life cycle inventory modelling of land use induced by crop consumption - Part 1: Conceptual analysis and methodological proposal

    DEFF Research Database (Denmark)

    Kløverpris, Jesper; Wenzel, Henrik; Nielsen, Per H.

    2008-01-01

    Background, Aims and Scope. The actual land use consequences of crop consumption are not very well reflected in existing life cycle inventories. The state of the art is that such inventories typically include data from crop production in the country in which the crop is produced, and consequently...... to reflect long-term changes, and possibly establishment of a link between crop demand and technological development. Through this approach, life cycle inventories for crops reflecting the actual land use consequences of consumption can be established.Recommendations and Perspectives. Further work (based...... use consequences of crop consumption.Results. Based on the current market trend for crops and an analysis of basic mechanisms in crop production, concepts for modelling how crop consumption affects the global agricultural area and the intensity of crop production are suggested. It is demonstrated how...

  11. Warfarin-induced sublingual hematoma mimicking Ludwig angina: Conservative management of a potentially life-threatening condition.

    LENUS (Irish Health Repository)

    Cashman, Emma

    2012-02-01

    Sublingual hematoma secondary to excessive anticoagulation is a rare, life-threatening condition. Reports in the literature have emphasized the importance of a prompt reversal of the causative coagulopathy by intravenous administration of vitamin K and fresh frozen plasma. In the event of an unstable airway, surgical intervention via tracheostomy or cricothyroidectomy is advocated. We report a case of sublingual hematoma that was treated conservatively, and we discuss the presentation and management of this entity.

  12. Warfarin-induced sublingual hematoma mimicking Ludwig angina: Conservative management of a potentially life-threatening condition.

    LENUS (Irish Health Repository)

    Cashman, Emma

    2011-02-01

    Sublingual hematoma secondary to excessive anticoagulation is a rare, life-threatening condition. Reports in the literature have emphasized the importance of a prompt reversal of the causative coagulopathy by intravenous administration of vitamin K and fresh frozen plasma. In the event of an unstable airway, surgical intervention via tracheostomy or cricothyroidectomy is advocated. We report a case of sublingual hematoma that was treated conservatively, and we discuss the presentation and management of this entity.

  13. Effect of hardening induced by cold expansion on damage fatigue accumulation and life assessment of Aluminum alloy 6082 T6

    Directory of Open Access Journals (Sweden)

    Bendouba Mostefa

    2012-12-01

    Full Text Available Hole cold expansion (HCE is an effective method to extend the fatigue life of mechanical structures. During cold expansion process compressive residual stresses around the expanded hole are generated. The enhancement of fatigue life and the crack initiation and growth behavior of a holed specimen were investigated by using the 6082 Aluminum alloy. The present study suggests a simple technical method for enhancement of fatigue life by a cold expansion hole of pre-cracked specimen. Fatigue damage accumulation of cold expanded hole in aluminum alloy which is widely used in transportation and in aeronautics was analyzed. Experimental tests were carried out using pre-cracked SENT specimens. Tests were performed in two and four block loading under constant amplitude. These tests were performed by using two and four blocks under uniaxial constant amplitude loading. The increasing and decreasing loading were carried. The experimental results were compared to the damage calculated by the Miner's rule and a new simple fatigue damage indicator. This comparison shows that the 'damaged stress model', which takes into account the loading history, yields a good estimation according to the experimental results. Moreover, the error is minimized in comparison to the Miner's model.

  14. Has long-term metal exposure induced changes in life history traits and genetic diversity of the enchytraeid worm Cognettia sphagnetorum (Vejd.)?

    International Nuclear Information System (INIS)

    Haimi, Jari; Knott, Karelyn Emily; Selonen, Salla; Laurikainen, Marjo

    2006-01-01

    We studied whether long-term metal exposure has affected life history traits, population growth patterns and genetic diversity of the asexual enchytraeid worm Cognettia sphagnetorum (Vejd.). Enchytraeids from metal contaminated and uncontaminated forest soil were compared by growing them individually in the laboratory and by following their population development in patchily Cu contaminated microcosms. Genetic differences between the two native populations were studied using allozyme electrophoresis. Individuals from the contaminated site had slower growth rate and they produced fewer fragments of larger size when compared to individuals from the uncontaminated site. In patchily Cu contaminated microcosms, C. sphagnetorum from the contaminated site had a slower population growth rate. Most alleles were shared by the two native populations, but there was greater diversity and more unique genotypes in the population living in the uncontaminated site. Overall, long-term exposure to metals has induced only slight changes in life history properties and clonal diversity of C. sphagnetorum. - Long-term exposure to metals caused only small changes in life histories of two populations of Cognettia sphagnetorum

  15. Deep sea minerals prolong life span of streptozotocin-induced diabetic rats by compensatory augmentation of the IGF-I-survival signaling and inhibition of apoptosis.

    Science.gov (United States)

    Liao, Hung-En; Shibu, Marthandam Asokan; Kuo, Wei-Wen; Pai, Pei-Ying; Ho, Tsung-Jung; Kuo, Chia-Hua; Lin, Jing-Ying; Wen, Su-Ying; Viswanadha, Vijaya Padma; Huang, Chih-Yang

    2016-07-01

    Consumption of deep sea minerals (DSM), such as magnesium, calcium, and potassium, is known to reduce hypercholesterolemia-induced myocardial hypertrophy and cardiac-apoptosis and provide protection against cardiovascular diseases. Heart diseases develop as a lethal complication among diabetic patients usually due to hyperglycemia-induced cardiac-apoptosis that causes severe cardiac-damages, heart failure, and reduced life expectancy. In this study, we investigated the potential of DSM and its related cardio-protection to increase the life expectancy in diabetic rats. In this study, a heart failure rat model was developed by using streptozotocin (65 mg kg(-1) ) IP injection. Different doses of DSM-1× (37 mg kg(-1) day(-1) ), 2× (74 mg kg(-1) day(-1) ) and 3× (111 mg kg(-1) day(-1) ), were administered to the rats through gavages for 4 weeks. The positive effects of DSM on the survival rate of diabetes rats were determined with respect to the corresponding effects of MgSO4 . Further, to understand the mechanism by which DSM enhances the survival of diabetic rats, their potential to regulate cardiac-apoptosis and control cardiac-dysfunction were examined. Echocardiogram, tissue staining, TUNEL assay, and Western blotting assay were used to investigate modulations in the myocardial contractile function and related signaling protein expression. The results showed that DSM regulate apoptosis and complement the cardiomyocyte proliferation by enhancing survival mechanisms. Moreover DSM significantly reduced the mortality rate and enhanced the survival rate of diabetic rats. Experimental results show that DSM administration can be an effective strategy to improve the life expectancy of diabetic subjects by improving cardiac-cell proliferation and by controlling cardiac-apoptosis and associated cardiac-dysfunction. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 769-781, 2016. © 2015 Wiley Periodicals, Inc.

  16. Early-life stress induces persistent alterationsin 5-HT1Areceptor and serotonin transporter mRNA expression in the adultrat brain.

    Directory of Open Access Journals (Sweden)

    Javier A. Bravo

    2014-04-01

    Full Text Available Early-life experience plays a major role in the stress response throughout life. Neonatal maternal separation (MS is an animal model of depression with an altered serotonergic response. We hypothesize that this alteration may be caused by differences in 5-HT1A receptor and serotonin transporter (SERT mRNA expression in brain areas involved in the control of emotions, memory and fear as well as in regions controlling the central serotonergic tone.To test this, Sprague-Dawley rats were subjected to MS for 3h daily during post-natal days 2-12. As control, age matched rats were not separated (NS from their dams. When animals reached adulthood (11-13 weeks brain was extracted and mRNA expression of 5-HT1A receptor in amygdala, hippocampus and dorsal raphé nucleus (DRN and SERT in the DRN was analyzed through in-situ hybridisation.Densitometric analysis revealed that MS increased 5-HT1A receptor mRNA expression in the amygdala, and reduced its expression in the DRN, but no changes were observed in the hippocampus in comparison to NS controls. Also, MS reduced SERT mRNA expression in the DRN when compared to NS rats.These results suggest that early-life stress induces persistent changes in 5-HT1A receptor and SERT mRNA expression in key brain regions involved in the development of stress-related psychiatric disorders. The reduction in SERT mRNA indicates an alteration that is in line with clinical findings such as polymorphic variants in individuals with higher risk of depression. These data may help to understand how early-life stress contributes to the development of mood disorders in adulthood.

  17. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.

    Directory of Open Access Journals (Sweden)

    Richard J Kraus

    2017-06-01

    Full Text Available When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs. We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV. Incubation of EBV-positive gastric carcinoma AGS-Akata and SNU-719 and Burkitt lymphoma Sal and KemIII cell lines with a prolyl hydroxylase inhibitor, L-mimosine or deferoxamine, or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens. ShRNA knockdown of HIF-1α significantly reduced deferoxamine-mediated lytic reactivation. HIF-1α directly bound the promoter of the EBV primary latent-lytic switch BZLF1 gene, Zp, activating transcription via a consensus hypoxia-response element (HRE located at nt -83 through -76 relative to the transcription initiation site. HIF-1α did not activate transcription from the other EBV immediate-early gene, BRLF1. Importantly, expression of HIF-1α induced EBV lytic-gene expression in cells harboring wild-type EBV, but not in cells infected with variants containing base-pair substitution mutations within this HRE. Human oral keratinocyte (NOK and gingival epithelial (hGET cells induced to differentiate by incubation with either methyl cellulose or growth in organotypic culture accumulated both HIF-1α and Blimp-1α, another cellular factor implicated in lytic reactivation. HIF-1α activity also accumulated along with Blimp-1α during B-cell differentiation into plasma cells. Furthermore, most BZLF1-expressing cells observed in lymphomas induced by EBV in NSG mice with a humanized immune system were located distal to blood vessels in hypoxic regions of the tumors. Thus, we conclude that HIF-1α plays central roles in both EBV's natural life cycle and EBV-associated tumorigenesis. We propose that drugs that induce HIF-1α protein accumulation are good candidates for

  18. Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life.

    Directory of Open Access Journals (Sweden)

    Catrina Sims-Robinson

    Full Text Available A high-fat diet (HFD, one of the major factors contributing to metabolic syndrome, which is associated with an increased risk of neurodegenerative diseases, leads to insulin resistance and cognitive impairment. It is not known whether these alterations are improved with dietary intervention. To investigate the long-term impact of a HFD on hippocampal insulin signaling and memory, C57BL6 mice were placed into one of three groups based on the diet: a standard diet (control, a HFD, or a HFD for 16 weeks and then the standard diet for 8 weeks (HF16. HFD-induced impairments in glucose tolerance and hippocampal insulin signaling occurred concurrently with deficits in both short- and long-term memory. Furthermore, these conditions were improved with dietary intervention; however, the HFD-induced decrease in insulin receptor expression in the hippocampus was not altered with dietary intervention. Our results demonstrate that memory deficits due to the consumption of a HFD at an early age are reversible.

  19. Opioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: findings from the National Health and Wellness Survey.

    Science.gov (United States)

    Bell, Timothy; Annunziata, Kathy; Leslie, John B

    2009-01-01

    To characterize the impact of opioid-induced constipation (OIC) on healthcare resource use, work productivity, and health-related quality of life (HRQOL) in patients receiving chronic opioid therapy. Data were collected via Internet questionnaires during the international National Health and Wellness Survey (NHWS) 2004 from individuals aged > or = 18 years who reported taking opioids for > or = 6 months. Healthcare resource utilization, Work Productivity, and Activity Impairment, and Short-Form 8 (SF-8) questionnaire responses were compared between those who did or did not report OIC. Data were available from 2,430 individuals receiving opioids, of whom 359 reported OIC. Participants with OIC reported significantly more physician visits (mean difference 3.84 visits; p hospitalization were observed. Respondents with OIC also reported significantly greater time missed from work, impairment while working, overall work impairment, and activity impairment (p constipation in patients receiving chronic opioid therapy.

  20. Stress-induced hypermutation as a physical property of life, a force of natural selection and its role in four thought experiments

    International Nuclear Information System (INIS)

    Hilbert, Lennart

    2013-01-01

    The independence of genetic mutation rate from selection is central to neo-Darwinian evolutionary theory. However, it has been continuously challenged for more than 30 years by experimental evidence of genetic mutation rate transiently increasing in response to stress (stress-induced hypermutation, SIH). The prominent concept of evolved evolvability (EE) explains that natural selection for strategies more competitive at evolutionary adaptation itself gives rise to mechanisms dynamically adjusting mutation rates to environmental stress. Here, we theoretically investigate the alternative (not mutually exclusive) hypothesis that SIH is an inherent physical property of all genetically reproducing life. We define stress as any condition lowering the capability of utilizing metabolic resources for genome storage and replication. This thermodynamical analysis indicates stress-induced increases in the genetic mutation rate in genome storage and in genome replication as inherent physical properties of genetically reproducing life. Further integrating SIH into an overall organismic thermodynamic budget identifies SIH as a force of natural selection, alongside death rate, replication rate and constitutive mutation rate differences. We execute four thought experiments with a non-recombinant lesion mutant strain to predict experimental observations due to SIH in response to different stresses and stress combinations. We find (1) acceleration of adaptation over models without SIH, (2) possibility of adaptation at high stresses which are not explicable by mutation in genome replication alone and (3) different adaptive potential under high growth-inhibiting versus high lethal stresses. The predictions are directly comparable to culture experiments (colony size time courses, antibacterial resistance assay and occurrence of lesion-reversion mutant colonies) and genome sequence analysis. Considering suggestions of drug-mediated disruption of SIH and attempts to target mutation

  1. THE EFFECT OF HERBAL ESSENTIAL OIL IN PRESERVATIVE SOLUTION, ON QUANTITATIVE, VASE LIFE, BACTERIA-INDUCED STEM XYLEM BLOCKAGE OF LISIANTHUS VAR. ECHO

    Directory of Open Access Journals (Sweden)

    Farzaneh Pourianejad

    2014-06-01

    Full Text Available In this study the effect of essential oil taken from medicinal plant as antibacterial components in preservative solution of Lisianthus var. Echo (Eustoma grandiflorum was investigated. The test was done with application of preservative solution. Cut flowers were treated with different concentrations of Thyme (Thymus vulgaris, Spearmint (Mentha spicata and Lavender (Lavandula officinalis essential oil in addition to Sucrose 2.5%. The results showed that there was the longest time in vase life with Thyme in 50 ppm (15.6 days and the control treatment showed the shortest vase life (11.6 days. Moreover, Thyme with 50 ppm had the highest effect on relative fresh weight and solution uptake. In addition, bacteria-induced stem xylem blockage, extracted from the end of stem, was cultured in NA medium culture with several concentrations of essential oil. The result showed that in pure concentration (100% inhibition was completed and in various concentrations of essential oil the bacterial population was reduced.

  2. Similar effects of two modified constraint-induced therapy protocols on motor impairment, motor function and quality of life in patients with chronic stroke

    Directory of Open Access Journals (Sweden)

    Wilma Costa Souza

    2015-03-01

    Full Text Available Modified constraint-induced movement therapy (CIMT protocols show motor function and real-world arm use improvement. Meanwhile it usually requires constant supervision by physiotherapists and is therefore more expensive than customary care. This study compared the preliminary efficacy of two modified CIMT protocols. A two-group randomized controlled trial with pre and post treatment measures and six months follow-up was conducted. Nineteen patients with chronic stroke received 10 treatment sessions distributed three to four times a week over 22 days. CIMT3h_direct group received 3 hours of CIMT supervised by a therapist (n=10 while CIMT1.5h_direct group had 1.5 hours of supervised CIMT+1.5 hours home exercises supervised by a caregiver (n=9. Outcome measures were the Fugl-Meyer Assessment, the Motor Activity Log, and the Stroke Specific Quality of Life Scale. The modified CIMT protocols were feasible and well tolerated. Improvements in motor function, real-world arm use and quality of life did not differ significantly between treated groups receiving either 3 or 1.5 hours mCIMT supervised by a therapist.

  3. Evaluation of the Efficacy of Aprepitant on the Prevention of Chemotherapy-Induced Nausea and Vomiting and Quality of Life with Functional Living Index Emesis

    Directory of Open Access Journals (Sweden)

    Görkem Aksu

    2013-03-01

    Full Text Available Objective: Functional Living Index Emesis (FLIE is developed to evaluate the relationship between emesis and it's effects on patient's daily life and is far more relevant to detect the effectiveness of antiemetic treatment compared with self-diary reports. In this study, the efficacy of oral neurokinin-1 antagonist aprepitant on the prevention of chemotherapy-induced nausea and vomiting and quality of life is evaluated with FLIE. Study Design: Cross sectional study. Material and Methods: Sixty patients with Non-Small Cell Lung Cancer (NSCLC receiving a chemotherapy regimen consisting of Cisplatin and Docetaxel were evaluated. The patients were prospectively randomized to two groups before the first cycle of chemotherapy. Patients in Group A (31 patients received 3 daily doses of aprepitant along with oral ondansetron and dexamethasone. The patients in group B (29 patients received only ondansetron and dexamathasone. The efficacy of both regimens was evaluated by a modified Turkish version of FLIE scale consisting of 18 questions. Results: The number of patients with complete response was 31 in the whole group. Of these 18 patients (58% were in Group A (Aprepitant and 13 patients in group B (42%. Median FLIE score in group A was 24.97 (±12.45 while it was 38.1 (±26.987 in group B and the difference was statistically significant (p=0.022. Total score >20 was seen in only 5 of 31 patients in aprepitant group (16% showing the significant efficiency of aprepitant on quality of life, while in group B, 13 of 29 patients (44% had total scores >20 (p=0.02. Conclusion: Regarding these findings, it is certain to state that aprepitant in combination with other drugs optimizes protection against both nausea and vomiting compared to the prior standard of care, and must be recommended as first-line therapy for patients who are treated with moderately or highly emetogenic chemotherapy.

  4. Stress-induced neuroplasticity: (mal)adaptation to adverse life events in patients with PTSD--a critical overview.

    Science.gov (United States)

    Deppermann, S; Storchak, H; Fallgatter, A J; Ehlis, A-C

    2014-12-26

    Stress is an adaptive response to demands of the environment and thus essential for survival. Exposure to stress triggers hypothalamic-pituitary-adrenocortical (HPA) axis activation and associated neurochemical reactions, following glucocorticoid release from the adrenal glands, accompanied by rapid physiological responses. Stimulation of this pathway results in the activation of specific brain regions, including the hippocampus, amygdala and prefrontal cortex which are enriched with glucocorticoid receptors (GRs). Recent findings indicate that the activation of GRs mediates the regulation of the brain-derived neurotrophic factor (BDNF). BDNF is crucial for neural plasticity, as it promotes cellular growth and synaptic changes. Hence stress-induced activation of these pathways leads to neuroplastic changes, including the formation of long-lasting memories of the experiences. As a consequence, organisms can learn from stressful events and respond in an adaptive manner to similar demands in the future. Whereas an optimal stress level leads to enhancement of memory performance, the exposure to extreme, traumatic or chronic stressors is a risk factor for psychopathologies which are associated with memory impairment and cognitive deficits such as posttraumatic stress disorder (PTSD). In this review article, we will outline the implications of stress exposure on memory formation involving the role of glucocorticoids and BDNF. Within this context, potential adverse effects of neuroplastic alterations will be discussed using the example of PTSD. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

  5. Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal Women: The SHAPE-2 Randomised Controlled Trial.

    Science.gov (United States)

    van Gemert, Willemijn A M; van der Palen, Job; Monninkhof, Evelyn M; Rozeboom, Anouk; Peters, Roelof; Wittink, Harriet; Schuit, Albertine J; Peeters, Petra H

    2015-01-01

    This study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight loss, and that exercise-induced weight loss is more effective for this than diet-induced weight loss. The SHAPE-2 trial was primarily designed to evaluate any additional effect of weight loss by exercise compared with a comparable amount of weight loss by diet on biomarkers relevant for breast cancer risk. In the present analysis we focus on HRQoL. We randomly assigned 243 eligible women to a diet (n = 97), exercise (n = 98), or control group (n = 48). Both interventions aimed for 5-6 kg weight loss. HRQoL was measured at baseline and after 16 weeks by the SF-36 questionnaire. Data of 214 women were available for analysis. Weight loss was 4.9 kg (6.1%) and 5.5 kg (6.9%) with diet and exercise, respectively. Scores of the SF-36 domain 'health change' increased significantly by 8.8 points (95% CI 1.6;16.1) with diet, and by 20.5 points (95% CI 13.2;27.7) with exercise when compared with control. Direct comparison of diet and exercise showed a statistically significantly stronger improvement with exercise. Both intervention groups showed a tendency towards improvements in most other domains, which were more pronounced in the exercise group, but not statistically different from control or each other. In a randomized trial in overweight-to-obese and inactive postmenopausal women a comparable 6%-7% weight loss was achieved by diet-only or mainly by exercise and showed improvements in physical and mental HRQoL domains, but results were not statistically significant in either the diet or exercise group. However, a modest weight loss does lead to a positive change in self-perceived health status. This effect was significantly larger with exercise-induced weight loss than with comparable diet-induced

  6. Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal Women: The SHAPE-2 Randomised Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Willemijn A M van Gemert

    Full Text Available This study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight loss, and that exercise-induced weight loss is more effective for this than diet-induced weight loss.The SHAPE-2 trial was primarily designed to evaluate any additional effect of weight loss by exercise compared with a comparable amount of weight loss by diet on biomarkers relevant for breast cancer risk. In the present analysis we focus on HRQoL. We randomly assigned 243 eligible women to a diet (n = 97, exercise (n = 98, or control group (n = 48. Both interventions aimed for 5-6 kg weight loss. HRQoL was measured at baseline and after 16 weeks by the SF-36 questionnaire.Data of 214 women were available for analysis. Weight loss was 4.9 kg (6.1% and 5.5 kg (6.9% with diet and exercise, respectively. Scores of the SF-36 domain 'health change' increased significantly by 8.8 points (95% CI 1.6;16.1 with diet, and by 20.5 points (95% CI 13.2;27.7 with exercise when compared with control. Direct comparison of diet and exercise showed a statistically significantly stronger improvement with exercise. Both intervention groups showed a tendency towards improvements in most other domains, which were more pronounced in the exercise group, but not statistically different from control or each other.In a randomized trial in overweight-to-obese and inactive postmenopausal women a comparable 6%-7% weight loss was achieved by diet-only or mainly by exercise and showed improvements in physical and mental HRQoL domains, but results were not statistically significant in either the diet or exercise group. However, a modest weight loss does lead to a positive change in self-perceived health status. This effect was significantly larger with exercise-induced weight loss than with comparable

  7. Studies on the mechanism of the epileptiform activity induced by U18666A. II. concentration, half-life and distribution of radiolabeled U18666A in the brain

    Energy Technology Data Exchange (ETDEWEB)

    Cenedella, R.J.; Sarkar, C.P.; Towns, L.

    1982-06-01

    The concentration, half-life, and distribution in brain of U18666A, a drug that can drastically alter cerebral lipids and induce a chronic epileptiform state, was determined following both acute and chronic drug administration. U18666A specifically labeled with tritium was prepared by custom synthesis. Brain levels of 1 x 10(-6)M and higher were reached soon after giving an acute 10-mg/kg dose (i.p. or s.c.) of U18666A containing 7-/sup 3/H-U18666A of known specific activity. A steady state concentration of 1 to 2 x 10(-6)M was reached with chronic injection of 10 mg/kg every 4th day, a treatment schedule that results in altered brain lipids and induction of epilepsy if begun soon after birth. The disappearance of U18666A from both brain and serum was described by two similar biexponential processes, a brief rapid clearance (t1/2 . 10 h) and a sustained and much slower one (t1/2 . 65 h). Brain levels of the drug were about 10 times higher than serum at all times examined. Few differences were seen in the regional distribution of radiolabeled drug in brain as determined by both direct analysis and by autoradiographic examination; but the drug did concentrate in lipid-rich subcellular fractions. For example, the synaptosome and myelin fractions each contained about 25-35% of both the total /sup 3/H-labeled drug and total lipid in whole brain. The lipid composition of these fractions was drastically altered in treated animals. In conclusion, the chronic epileptiform state induced by U18666A does not appear to involve localization of the drug in a specific brain region or particular cell type. Rather, the condition could involve localization of the drug in lipid-rich membranes and marked changes in the composition of these membranes.

  8. Neuron-specific knockdown of the Drosophila fat induces reduction of life span, deficient locomotive ability, shortening of motoneuron terminal branches and defects in axonal targeting.

    Science.gov (United States)

    Nakamura, Aya; Tanaka, Ryo; Morishita, Kazushige; Yoshida, Hideki; Higuchi, Yujiro; Takashima, Hiroshi; Yamaguchi, Masamitsu

    2017-07-01

    Mutations in FAT4 gene, one of the human FAT family genes, have been identified in Van Maldergem syndrome (VMS) and Hennekam lymphangiectasia-lymphedema syndrome (HS). The FAT4 gene encodes a large protein with extracellular cadherin repeats, EGF-like domains and Laminin G-like domains. FAT4 plays a role in tumor suppression and planar cell polarity. Drosophila contains a human FAT4 homologue, fat. Drosophila fat has been mainly studied with Drosophila eye and wing systems. Here, we specially knocked down Drosophila fat in nerve system. Neuron-specific knockdown of fat shortened the life span and induced the defect in locomotive abilities of adult flies. In consistent with these phenotypes, defects in synapse structure at neuromuscular junction were observed in neuron-specific fat-knockdown flies. In addition, aberrations in axonal targeting of photoreceptor neuron in third-instar larvae were also observed, suggesting that fat involves in axonal targeting. Taken together, the results indicate that Drosophila fat plays an essential role in formation and/or maintenance of neuron. Both VMS and HS show mental retardation and neuronal defects. We therefore consider that these two rare human diseases could possibly be caused by the defect in FAT4 function in neuronal cells. © 2017 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

  9. Laser-Induced Fluorescence Emission (L.I.F.E.): searching for Mars organics with a UV-enhanced PanCam.

    Science.gov (United States)

    Storrie-Lombardi, Michael C; Muller, Jan-Peter; Fisk, Martin R; Cousins, Claire; Sattler, Birgit; Griffiths, Andrew D; Coates, Andrew J

    2009-12-01

    The European Space Agency will launch the ExoMars mission in 2016 with a primary goal of surveying the martian subsurface for evidence of organic material. We have recently investigated the utility of including either a 365 nm light-emitting diode or a 375 nm laser light source in the ExoMars rover panoramic camera (PanCam). Such a modification would make it feasible to monitor rover drill cuttings optically for the fluorescence signatures of aromatic organic molecules and map the distribution of polycyclic aromatic hydrocarbons (PAHs) as a function of depth to the 2 m limit of the ExoMars drill. The technique described requires no sample preparation, does not consume irreplaceable resources, and would allow mission control to prioritize deployment of organic detection experiments that require sample destruction, expenditure of non-replaceable consumables, or both. We report here for the first time laser-induced fluorescence emission (L.I.F.E.) imaging detection limits for anthracene, pyrene, and perylene targets doped onto a Mars analog granular peridotite with a 375 nm Nichia laser diode in optically uncorrected wide-angle mode. Data were collected via the Beagle 2 PanCam backup filter wheel fitted with original blue (440 nm), green (530 nm), and red (670 nm) filters. All three PAH species can be detected with the PanCam green (530 nm) filter. Detection limits in the green band for signal-to-noise ratios (S/N) > 10 are 49 parts per million (ppm) for anthracene, 145 ppm for pyrene, and 20 ppm for perylene. The anthracene detection limit improves to 7 ppm with use of the PanCam blue filter. We discuss soil-dependent detection limit constraints; use of UV excitation with other rover cameras, which provides higher spatial resolution; and the advantages of focused and wide-angle laser modes. Finally, we discuss application of L.I.F.E. techniques at multiple wavelengths for exploration of Mars analog extreme environments on Earth, including Icelandic hydrothermally

  10. Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study

    Science.gov (United States)

    Shiga, Hisashi; Miyazawa, Teruko; Kinouchi, Yoshitaka; Takahashi, Seiichi; Tominaga, Gen; Takahashi, Hiroki; Takagi, Sho; Obana, Nobuya; Kikuchi, Tatsuya; Oomori, Shinya; Nomura, Eiki; Shiraki, Manabu; Sato, Yuichirou; Takahashi, Shuichiro; Umemura, Ken; Yokoyama, Hiroshi; Endo, Katsuya; Kakuta, Yoichi; Aizawa, Hiroki; Matsuura, Masaki; Kimura, Tomoya; Kuroha, Masatake; Shimosegawa, Tooru

    2013-01-01

    Objective Stress is thought to be one of the triggers of relapses in patients with inflammatory bowel disease (IBD). We examined the rate of relapse in IBD patients before and after the Great East Japan Earthquake. Design A retrospective cohort study. Settings 13 hospitals in Japan. Participants 546 ulcerative colitis (UC) and 357 Crohn's disease (CD) patients who received outpatient and inpatient care at 13 hospitals located in the area that were seriously damaged by the earthquake. Data on patient's clinical characteristics, disease activity and deleterious effects of the earthquake were obtained from questionnaires and hospital records. Primary outcome We evaluated the relapse rate (from inactive to active) across two consecutive months before and two consecutive months after the earthquake. In this study, we defined ‘active’ as conditions with a partial Mayo score=2 or more (UC) or a Harvey-Bradshaw index=6 or more (CD). Results Among the UC patients, disease was active in 167 patients and inactive in 379 patients before the earthquake. After the earthquake, the activity scores increased significantly (p<0.0001). A total of 86 patients relapsed (relapse rate=15.8%). The relapse rate was about twice that of the corresponding period in the previous year. Among the CD patients, 86 patients had active disease and 271 had inactive disease before the earthquake. After the earthquake, the activity indices changed little. A total of 25 patients experienced a relapse (relapse rate=7%). The relapse rate did not differ from that of the corresponding period in the previous year. Multivariate analyses revealed that UC, changes in dietary oral intake and anxiety about family finances were associated with the relapse. Conclusions Life-event stress induced by the Great East Japan Earthquake was associated with relapse in UC but not CD. PMID:23396562

  11. Sex differences in early growth during the first three years of life in offspring from mothers with pregnancy-induced hypertension.

    Science.gov (United States)

    Mitsui, Takashi; Masuyama, Hisashi; Eguchi, Takeshi; Tamada, Shoko; Eto, Eriko; Hayata, Kei; Hiramatsu, Yuji

    2016-10-01

    Newborns born to mothers with pregnancy-induced hypertension (PIH) are thought to be at high risk for lifestyle-related diseases, such as obesity and hypertension, in adulthood. A longitudinal study of 78 pregnant women with PIH and their newborns, who visited Okayama University Hospital from 2009 to 2013. We investigated the change in growth of offspring born to mothers with PIH and compared it with the standard growth curve in Japanese to examine whether there was rapid catch-up growth during the first 3years of life. Subjects were 78 pregnant women with PIH and their offspring, who visited Okayama University Hospital from 2009 to 2013. Valid responses were obtained from 29 of 78 (37.1%) women. Body weight and length at birth were at the third percentile or less in females, and at the 10th percentile or less, in males. When body weight and length were compared at 6months, 18months, and 3years old between male and female toddlers, male toddlers slowly caught up until 3years old, but female toddlers rapidly caught up in the first 6months. Furthermore, in newborns with fetal growth restriction caused by the intrauterine environment of PIH, differences in physical development between male and female toddlers were more remarkable. There is a significant sex difference in catch-up growth during the first 3years, which might be involved in lifestyle-related diseases in adulthood, suggesting continuous follow-up is necessary, especially for female offspring. Copyright © 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  12. Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life.

    Science.gov (United States)

    Novakova, Silviya Mihaylova; Staevska, Maria Toncheva; Novakova, Plamena Ivanova; Yoncheva, Manuela Dimitrova; Bratoycheva, Maria Stoykova; Musurlieva, Nina Mihaylova; Tzekov, Valeri Dimitrov; Nicolov, Dimitar Georgiev

    2017-09-29

    Along with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. Тhe advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis. A total number of 191 adult patients [105 (54,979%) men; mean age 27.3 years (SD-6.14)] with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust mites or grass pollen were prospectively evaluated in the course of management of their disease. Health-related quality of life was assessed by Rhinoconjunctivitis Quality of Life Questionnaire at baseline and after three-year course of sublingual immunotherapy. The mean overall Qol score assessed at baseline and at the end of the third year of treatment decreased significantly in patients treated with HDM extract (from 2.95 to 0.76) as well as with Grass pollen extract (from 2.83 to 1.22) (р life provided evidence that a three-year course of SLIT with HDM extract as well as with grass pollen extract significantly increased QoL in patients with allergic rhinitis.

  13. SIMPLE LIFE AND RELIGION

    Directory of Open Access Journals (Sweden)

    Ahmet YILDIRIM

    2014-07-01

    Full Text Available Individuals in terms of the economy in which we live is one of the most important phenomenon of the century. This phenomenon present itself as the only determinant of people's lives by entering almost makes itself felt. The mo st obvious objective needs of the economy by triggering motive is to induce people to consume . Consumer culture pervades all aspects of the situation are people . Therefore, these people have the blessing of culture , beauty and value all in the name of w hatever is consumed. This is way out of the siege of moral and religious values we have is to go back again . Referred by local cultural and religious values, based on today increasingly come to the fore and the Muslim way of life appears to be close to th e plain / lean preferred by many people life has been a way of life. Even the simple life , a way of life in the Western world , a conception of life , a philosophy, a movement as it has become widely accepted. Here in determining the Muslim way of life Pr ophet. Prophet (sa lived the kind of life a very important model, sample, and determining which direction is known. Religious values, which is the carrier of the prophets, sent to the society they have always been examples and models. Because every aspect of human life, his life style and the surrounding area has a feature. We also value his life that he has unknowingly and without learning and skills and to understand it is not possible to live our religion . We also our presentation, we mainly of Islam o utlook on life and predicted life - style, including the Prophet of Islam 's (sa simple life to scrutinize and lifestyle issues related to reveal , in short Islam's how life has embraced and the Prophet. Prophet's will try to find answers to questions reg arding how to live.

  14. Metabolic programming of zebra fish Danio rerio uncovered. Physiological performance as explained by dynamic energy budget theory and life-cycle consequence of uranium induced perturbations

    International Nuclear Information System (INIS)

    Starrlight, A.

    2012-01-01

    The aim of this dissertation is to characterize the toxicity of uranium on the metabolism of zebra fish, nio rerio. The first three chapters of this manuscript are dedicated to characterizing the blank metabolism of zebra fish. I used the Dynamic Energy Budget (deb) theory for this characterisation; it is presently the only theory that covers the full life cycle of the organism and quantifies feeding, assimilation, growth, reproduction, maturation, maintenance and ageing. Any metabolic effect of uranium should appear as effects on one or more of these fundamental processes. Since the life span of zebra fish is some four and a half years, and larger individuals respond slower to chemical stress, the focus was on the early life stages. Considerable breakthroughs in the quantification of zebra fish development, growth and reproduction have been made. It turned out the zebra fish accelerates its metabolism after birth till metamorphosis, when acceleration ceases. This process is seen in some, but not all, species of fish. Another striking conclusion was that somatic maintenance was much higher than is typical for fish. We don't yet have an explanation for this funding. Further it turned out that the details of reproduction matter: allocation to reproduction (in adults) accumulates in a reproduction buffer and this buffer is used to prepare batches of eggs. We needed to detail this preparation process to understand how zebra fish can eliminate uranium via eggs. Deb theory specifies that a particular developmental stage (birth, metamorphosis, puberty) is reached at specified levels of maturity. For different temperatures and food levels, that can occur at different ages and body sizes. We extended this idea to include all the described morphologically defined developmental stages of the zebra fish in the literature; the observed variations in ages and body sizes can now be explained by deb theory. To test if deb theory can also explain perturbations of maturation, we

  15. Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanic Acid (PFOA) Exposure in CD-1 Mice: Low Doses Induce Elevated Serum, Leptin, Insulin, and Overweight in Mid-Life.

    Science.gov (United States)

    The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing prenatal pregnancy loss, increased neonatal mortality, delayed eye opening, and abnormal mammary gland growth in animals exposed during fetal life. PFOA is found in the ser...

  16. Using Human Life Stage PBPK/PD Model Predictions of Perchlorate-Induced Iodide Inhibition to Inform Risk Assessment in Sensitive Populations

    National Research Council Canada - National Science Library

    Mattie, David R; Sterner, Teresa R; Merrill, Elaine A; Clewell, Rebecca A

    2006-01-01

    .... Recently, existing physiologically based pharmacokinetics/pharmacodynamic (PBPK/PD) models across life-stages in rat and in adult human were expanded to describe inhibition kinetics during-perinatal development in humans...

  17. A unified metabolism for Mars: A new approach developed from research on extraterrestrial life detection by enzymatically induced exchange of O 18

    Science.gov (United States)

    1972-01-01

    A general graded life detection approach ranging from environmental and in situ observations to specific metabolic experiments on Mars is reported. A zero dead volume leak and computer mediated data acquisition system is also discussed. Soil analyses were also conducted.

  18. Development of kairomone based control programs for cocoa pod borer

    Science.gov (United States)

    The Cocoa Pod Borer moth presents a unique opportunity to develop host volatile attractants for control strategies for the following reasons. First, knowing what volatiles are critical for host finding by females will allow for development of mass trapping and/or attract and kill strategies to cont...

  19. Field attraction of the vine weevil Otiorhynchus sulcatus to Kairomones

    NARCIS (Netherlands)

    Tol, van R.W.H.M.; Bruck, D.J.; Griepink, F.C.; Kogel, de W.J.

    2012-01-01

    Root weevils in the genus Otiorhynchus are cited as one of the most important pests in the major nursery and small fruit production areas throughout the United States, western Canada, and northern Europe. A major problem in combating weevil attack is monitoring and timing of control measures.

  20. Early-life adversity-induced long-term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals.

    Science.gov (United States)

    Chistiakov, Dimitry A; Chekhonin, Vladimir P

    2017-06-05

    To examine whether chronic physical aggression (CPA) in adulthood can be epigenetically programmed early in life due to exposure to early-life adversity. Literature search of public databases such as PubMed/MEDLINE and Scopus. Children/adolescents susceptible for CPA and exposed to early-life abuse fail to efficiently cope with stress that in turn results in the development of CPA later in life. This phenomenon was observed in humans and animal models of aggression. The susceptibility to aggression is a complex trait that is regulated by the interaction between environmental and genetic factors. Epigenetic mechanisms mediate this interaction. Subjects exposed to stress early in life exhibited long-term epigenetic programming that can influence their behaviour in adulthood. This programming affects expression of many genes not only in the brain but also in other systems such as neuroendocrine and immune. The propensity to adult CPA behaviour in subjects experienced to early-life adversity is mediated by epigenetic programming that involves long-term systemic epigenetic alterations in a whole genome.

  1. The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial.

    Science.gov (United States)

    Marx, Wolfgang; McCarthy, Alexandra L; Ried, Karin; McKavanagh, Dan; Vitetta, Luis; Sali, Avni; Lohning, Anna; Isenring, Elisabeth

    2017-08-12

    Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic factors. Over three consecutive chemotherapy cycles, nausea was more prevalent than vomiting (47% vs. 12%). In chemotherapy Cycle 1, intervention participants reported significantly better QoL related to CIN ( p = 0.029), chemotherapy-induced nausea and vomiting (CINV)-related QoL ( p = 0.043), global QoL ( p = 0.015) and less fatigue ( p = 0.006) than placebo participants. There were no significant results in Cycle 2. In Cycle 3, global QoL ( p = 0.040) and fatigue ( p = 0.013) were significantly better in the intervention group compared to placebo. This trial suggests adjuvant ginger supplementation is associated with better chemotherapy-induced nausea-related quality of life and less cancer-related fatigue, with no difference in adverse effects compared to placebo.

  2. Quality of life after diet or exercise-induced weight loss in overweight to obese postmenopausal women: The SHAPE-2 randomised controlled trial

    NARCIS (Netherlands)

    van Gemert, Willemijn A.M.; van der Palen, Jacobus Adrianus Maria; Monninkhof, Evelyn M.; Rozeboom, Anouk; Peters, Roelof; Wittink, Harriet; Schuit, Albertine J.; Peeters, Petra H.

    2015-01-01

    Introduction This study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight

  3. Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal Women: The SHAPE-2 Randomised Controlled Trial

    NARCIS (Netherlands)

    van Gemert, W.A.M.; van der Palen, J.; Monninkhof, E.M.; Rozeboom, A.; Peters, R; Wittink, H.; Schuit, A.J.; Peeters, P.H.

    2015-01-01

    Introduction: This study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight

  4. Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal Women : The SHAPE-2 Randomised Controlled Trial

    NARCIS (Netherlands)

    van Gemert, Willemijn A. M.; van der Palen, Job; Monninkhof, Evelyn M.; Rozeboom, Anouk; Peters, Roelof; Wittink, Harriet; Schuit, Albertine J.; Peeters, Petra H.

    2015-01-01

    Introduction This study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight

  5. Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Wohlrab J

    2014-08-01

    Full Text Available Johannes Wohlrab,1 Nikola Bangemann,2 Anke Kleine-Tebbe,3 Marc Thill,4,5 Sherko Kümmel,6 Eva-Maria Grischke,7 Rainer Richter,8 Sophie Seite,9 Diana Lüftner10 1Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale, 2Interdisciplinary Breast Centre, University Hospital Charité Berlin, Campus Benjamin Franklin, Berlin, Germany, 3Breast Centre DRK Hospital, Berlin, 4Breast Centre University of Lübeck, Department of Gynaecology and Obstetrics, Lübeck, 5Department of Gynaecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt am Main, 6Breast Centre and Clinic of Senology, Hospital Essen-Mitte, Essen, 7Breast Centre University of Tübingen, Department of Gynaecology, Tübingen, 8L'Oréal, Deutschland GmbH, Düsseldorf, 9La Roche-Posay, Dermatological Laboratories, Asnières, France; 10University Hospital Charité Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3. Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and

  6. Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life.

    Directory of Open Access Journals (Sweden)

    Mei Bai

    Full Text Available Some environmental stressors lead to the onset of depression via inhibiting hippocampal BDNF expression, but other environmental stressors-induced depression exhibits no change in BDNF expression. The underlying mechanisms behind the divergence remain unknown. In this study, depression-like behaviors were induced in rats by maternal deprivation (MD and chronic unpredictable stress (CUPS. Depression-like behaviors were tested by open field test, forced swimming test, and sucrose consumption test. BDNF and miR-16 expressions in the hippocampus were examined by real-time PCR. MD and CUPS rats crawled less distance, exhibited decreased vertical activity, and produced more fecal pellets than control rats in the open field test. However, MD rats crawled less distance and produced significantly less fecal pellets than CUPS rats. In the forced swimming and sucrose consumption tests, CUPS and MD rats exhibited longer floating time and consumed less sucrose than control rats, but MD rats exhibited shorter floating time and consumed less sucrose than CUPS rats. MD but not CUPS rats showed lower BDNF mRNA and higher miR-16 expression than control rats. In MD rats, BDNF mRNA expression negatively correlated with the expression of miR-16. BDNF expression positively correlated with the total distance rats crawled and vertical activity in the open field test while miR-16 expression negatively correlated the two behaviors. BDNF positively correlated with sucrose preference rate while miR-16 negatively correlated with sucrose preference rate of the sucrose consumption test. Our study suggests that MD and CUPS induced different depression-like behaviors in rats. Depression induced by MD but not CUPS was significantly associated with upregulation of miR-16 and possibly subsequent downregulation of BDNF in hippocampus.

  7. The effectiveness of a saline mouth rinse regimen and education programme on radiation-induced oral mucositis and quality of life in oral cavity cancer patients: A randomised controlled trial.

    Science.gov (United States)

    Huang, B-S; Wu, S-C; Lin, C-Y; Fan, K-H; Chang, J T-C; Chen, S-C

    2018-03-01

    Radiation therapy (RT) and concurrent chemotherapy RT (CCRT) generate radiation-induced oral mucositis (OM) and lower quality of life (QOL). This study assessed the impact of a saline mouth rinse regimen and education programme on radiation-induced OM symptoms, and QOL in oral cavity cancer (OCC) patients receiving RT or CCRT. Ninety-one OCC patients were randomly divided into a group that received saline mouth rinses and an education programme and a control group that received standard care. OM symptoms and QOL were assessed with the WHO Oral Toxicity Scale, MSS-moo and UW-QOL. Data were collected at the first postoperative visit to the radiation department (T0) and at 4 weeks and 8 weeks after beginning RT or CCRT. Patients in both groups had significantly higher levels of physical and social-emotional QOL at 8 weeks after beginning RT or CCRT compared to the first visit. Patients in the saline rinse group had significantly better physical and social-emotional QOL as compared to the standard care group at 8 weeks. Radiation-induced OM symptoms and overall QOL were not different between the groups. We thus conclude the saline rinse and education programme promote better physical and social-emotional QOL in OCC patients receiving RT/CCRT. © 2018 John Wiley & Sons Ltd.

  8. Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping

    DEFF Research Database (Denmark)

    Vindas, Marco A.; Fokos, Stefanos; Pavlidis, Michail

    2018-01-01

    Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected...... of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv...

  9. Mindfulness and zest for life buffer the negative effects of experimentally-induced perceived burdensomeness and thwarted belongingness: Implications for theories of suicide.

    Science.gov (United States)

    Collins, Khan R L; Best, Ida; Stritzke, Werner G K; Page, Andrew C

    2016-07-01

    Suicide research can be enhanced by an ability to safely manipulate putative causal variables. The present studies developed an experimental task to modify risk factors identified by the interpersonal theory of suicide (perceived burdensomeness and thwarted belongingness) and examine their hypothesized suppressive effect on persistence in adversity in undergraduate university students. Variables that may moderate the impact of these risk factors on persistence (zest for life and mindful awareness) were incorporated as potential resilience factors. Study 1 (N = 92) found elevated burdensomeness and diminished belongingness significantly impaired persistence. Additionally, these predicted effects were moderated by individual differences in zest for life. In Study 2 (N = 52), individuals trained in mindfulness prior to the experimental task displayed greater persistence relative to controls. Findings provide experimental support for the role of perceived burdensomeness and thwarted belongingness in the manner predicted by the interpersonal theory, and demonstrate a way to experimentally test the effects of resilience factors that reduce the impact of these interpersonal factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  10. Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.

    Science.gov (United States)

    Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis; O'Connor, George T; Bacharier, Leonard B; Bloomberg, Gordon R; Kattan, Meyer; Wood, Robert A; Presnell, Scott; LeBeau, Petra; Jaffee, Katy; Visness, Cynthia M; Busse, William W; Gern, James E

    2018-03-05

    Childhood asthma in inner-city populations is a major public health burden, and understanding early-life immune mechanisms that promote asthma onset is key to disease prevention. Children with asthma demonstrate a high prevalence of aeroallergen sensitization and T H 2-type inflammation; however, the early-life immune events that lead to T H 2 skewing and disease development are unknown. We sought to use RNA sequencing of PBMCs collected at age 2 years to determine networks of immune responses that occur in children with allergy and asthma. In an inner-city birth cohort with high asthma risk, we compared gene expression using RNA sequencing in PBMCs collected at age 2 years between children with 2 or more aeroallergen sensitizations, including dust mite, cockroach, or both, by age 3 years and asthma by age 7 years (cases) and matched control subjects who did not have any aeroallergen sensitization or asthma by age 7 years. PBMCs from the cases showed higher levels of expression of natural killer (NK) cell-related genes. After cockroach or dust mite allergen but not tetanus antigen stimulation, PBMCs from the cases compared with the control subjects showed differential expression of 244 genes. This gene set included upregulation of a densely interconnected NK cell-like gene network reflecting a pattern of cell activation and induction of inflammatory signaling molecules, including the key T H 2-type cytokines IL9, IL13, and CCL17, as well as a dendritic cell-like gene network, including upregulation of CD1 lipid antigen presentation molecules. The NK cell-like response was reproducible in an independent group of children with later-onset allergic sensitization and asthma and was found to be specific to only those children with both aeroallergen sensitization and asthma. These findings provide important mechanistic insight into an early-life immune pathway involved in T H 2 polarization, leading to the development of allergic asthma. Copyright © 2018 American

  11. Picturing Life

    Directory of Open Access Journals (Sweden)

    Molly Bathje MS, OTR/L

    2013-08-01

    Full Text Available The cover art of the summer 2013 issue of The Open Journal of Occupational Therapy provided by Jonathan Darnall reflects his unique life perspective, current roles, and values. An exploration of Jon’s life experience reveals how creative arts, including photography, have positively influenced his life and inform OT practitioners about the benefits of photography as an intervention and an occupation.

  12. Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats.

    Science.gov (United States)

    Möller, Frank Josef; Pemp, Daniela; Soukup, Sebastian T; Wende, Kathleen; Zhang, Xiajie; Zierau, Oliver; Muders, Michael H; Bosland, Maarten C; Kulling, Sabine E; Lehmann, Leane; Vollmer, Günter

    2016-08-01

    There is an ongoing debate whether the intake of soy-derived isoflavones (sISO) mediates beneficial or adverse effects with regard to breast cancer risk. Therefore, we investigated whether nutritional exposure to a sISO-enriched diet from conception until adulthood impacts on 17β-estradiol (E2)-induced carcinogenesis in the rat mammary gland (MG). August-Copenhagen-Irish (ACI) rats were exposed to dietary sISO from conception until postnatal day 285. Silastic tubes containing E2 were used to induce MG tumorigenesis. Body weight, food intake, and tumor growth were recorded weekly. At necropsy, the number, position, size, and weight of each tumor were determined. Plasma samples underwent sISO analysis, and the morphology of MG was analyzed. Tumor incidence and multiplicity were reduced by 20 and 56 %, respectively, in the sISO-exposed rats compared to the control rats. Time-to-tumor onset was shortened from 25 to 20 weeks, and larger tumors developed in the sISO-exposed rats. The histological phenotype of the MG tumors was independent of the sISO diet received, and it included both comedo and cribriform phenotypes. Morphological analyses of the whole-mounted MGs also showed no diet-dependent differences. Lifelong exposure to sISO reduced the overall incidence of MG carcinomas in ACI rats, although the time-to-tumor was significantly shortened.

  13. Sodium Butyrate, a Histone Deacetylase Inhibitor, Reverses Behavioral and Mitochondrial Alterations in Animal Models of Depression Induced by Early- or Late-life Stress.

    Science.gov (United States)

    Valvassori, Samira S; Resende, Wilson R; Budni, Josiane; Dal-Pont, Gustavo C; Bavaresco, Daniela V; Réus, Gislaine Z; Carvalho, André F; Gonçalves, Cinara L; Furlanetto, Camila B; Streck, Emilio L; Quevedo, João

    2015-01-01

    The aim of the present study was to evaluate the effects of sodium butyrate on depressive-like behavior and mitochondrial alteration parameters in animal models of depression induced by maternal deprivation or chronic mild stress in Wistar rats. maternal deprivation was established by separating pups from their mothers for 3 h daily from postnatal day 1 to day 10. Chronic mild stress was established by water deprivation, food deprivation, restraint stress, isolation and flashing lights. Sodium butyrate or saline was administered twice a day for 7 days before the behavioral tests. Depressive behavior was evaluated using the forced swim test. The activity of tricarboxylic acid cycle enzymes (succinate dehydrogenase and malate dehydrogenase) and of mitochondrial chain complexes (I, II, II-III and IV) was measured in the striatum of rats. From these analyses it can be observed that sodium butyrate reversed the depressive-like behavior observed in both animal models of depression. Additionally, maternal deprivation and chronic mild stress inhibited mitochondrial respiratory chain complexes and increased the activity of tricarboxylic acid cycle enzymes. Sodium butyrate treatment reversed -maternal deprivation and chronic mild stress- induced dysfunction in the striatum of rats. In conclusion, sodium butyrate showed antidepressant effects in maternal deprivation and chronic mild stress-treated rats, and this effect can be attributed to its action on the neurochemical pathways related to depression.

  14. Impact of diabetes on treatment-induced changes in left ventricular structure and function in hypertensive patients with left ventricular hypertrophy. The LIFE study

    DEFF Research Database (Denmark)

    Gerdts, E; Okin, P M; Omvik, P

    2009-01-01

    in diabetic and non-diabetic groups during treatment (33/18 vs. 28/16mmHg (ns)), diabetes was associated with higher prevalence of persistent LVH (47 vs. 39%, pdiabetes independently predicted less LV mass reduction and less improvement in stress-corrected LV midwall......BACKGROUND AND AIM: Diabetes is associated with left ventricular hypertrophy (LVH) and impaired systolic function in hypertensive patients, but less is known about its impact on LVH regression and functional improvement during antihypertensive treatment. METHODS AND RESULTS: We performed annual...... echocardiography in 730 non-diabetic and 93 diabetic patients (aged 55-80 years) with hypertension and electrocardiographic LVH during 4.8-year losartan- or atenolol-based treatment in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Baseline mean blood pressure (BP) and LV mass did...

  15. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.

    Science.gov (United States)

    Walker, Claire-Dominique; Bath, Kevin G; Joels, Marian; Korosi, Aniko; Larauche, Muriel; Lucassen, Paul J; Morris, Margaret J; Raineki, Charlis; Roth, Tania L; Sullivan, Regina M; Taché, Yvette; Baram, Tallie Z

    2017-09-01

    The immediate and long-term effects of exposure to early life stress (ELS) have been documented in humans and animal models. Even relatively brief periods of stress during the first 10 days of life in rodents can impact later behavioral regulation and the vulnerability to develop adult pathologies, in particular an impairment of cognitive functions and neurogenesis, but also modified social, emotional, and conditioned fear responses. The development of preclinical models of ELS exposure allows the examination of mechanisms and testing of therapeutic approaches that are not possible in humans. Here, we describe limited bedding and nesting (LBN) procedures, with models that produce altered maternal behavior ranging from fragmentation of care to maltreatment of infants. The purpose of this paper is to discuss important issues related to the implementation of this chronic ELS procedure and to describe some of the most prominent endpoints and consequences, focusing on areas of convergence between laboratories. Effects on the hypothalamic-pituitary adrenal (HPA) axis, gut axis and metabolism are presented in addition to changes in cognitive and emotional functions. Interestingly, recent data have suggested a strong sex difference in some of the reported consequences of the LBN paradigm, with females being more resilient in general than males. As both the chronic and intermittent variants of the LBN procedure have profound consequences on the offspring with minimal external intervention from the investigator, this model is advantageous ecologically and has a large translational potential. In addition to the direct effect of ELS on neurodevelopmental outcomes, exposure to adverse early environments can also have intergenerational impacts on mental health and function in subsequent generation offspring. Thus, advancing our understanding of the effect of ELS on brain and behavioral development is of critical concern for the health and wellbeing of both the current

  16. Early Life Exposure to Chronic Intermittent Hypoxia Primes Increased Susceptibility to Hypoxia-Induced Weakness in Rat Sternohyoid Muscle During Adulthood

    Directory of Open Access Journals (Sweden)

    Fiona B Mcdonald

    2016-03-01

    Full Text Available Intermittent hypoxia is a feature of apnea of prematurity, chronic lung disease and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH during postnatal development (pCIH causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 hours of delivery, pups and their respective dams were exposed to CIH: 90s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 hrs per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH, where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life.

  17. Early life exposure to chronic intermittent Hypoxia Primes Increased Susceptibility to Hypoxia-Induced Weakness in Rat Sternohyoid Muscle during adulthood.

    LENUS (Irish Health Repository)

    McDonald, Fiona B

    2016-03-01

    Intermittent hypoxia is a feature of apnea of prematurity (AOP), chronic lung disease, and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH) during postnatal development (pCIH) causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and\\/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 h of delivery, pups and their respective dams were exposed to CIH: 90 s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 h per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH), where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm) weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life.

  18. Life-threatening urethral hemorrhage after placement of a Foley catheter in a patient with uroseptic disseminated intravascular coagulation due to chronic urinary retention induced by untreated benign prostatic hyperplasia.

    Science.gov (United States)

    Ikegami, Yukihiro; Yoshida, Keisuke; Imaizumi, Tsuyoshi; Isosu, Tsuyoshi; Kurosawa, Shin; Murakawa, Masahiro

    2016-10-01

    A 77-year-old man with severe septic disseminated intravascular coagulation following urinary infection was transported to our hospital. He had developed urinary retention induced by untreated prostatic hyperplasia. Immediate drainage with a Foley catheter was successfully carried out, but the hematuria progressed to life-threatening hemorrhage. Complete hemostasis was impossible by surgical treatment because the tissue around the prostatic urethra was very fragile and hemorrhagic. Organized treatments (continuous hemodiafiltration combined with polymyxin-B immobilized fiber column hemoperfusion and systemic treatment with antibiotics and coagulation factors) were commenced soon after the operation. The patient eventually recovered from the septic disseminated intravascular coagulation. This case report illustrates the risk of placement of Foley catheters in patients with severe septic disseminated intravascular coagulation.

  19. Histopathological changes induced by acute toxicity of mercuric chloride on the air-breathing organ (branchial diverticulum) of the life-fish Heteropneustes (= Saccobranchus) fossilis (BLOCH)

    Energy Technology Data Exchange (ETDEWEB)

    Rajan, M.T. (Histochemistry and Histopathology Lab., Dept. of Zoology, Banaras Hindu Univ., Varanasi (India)); Banerjee, T.K. (Histochemistry and Histopathology Lab., Dept. of Zoology, Banaras Hindu Univ., Varanasi (India))

    1993-01-01

    Toxicity induced by 0.3 ppm (96 h LC[sub 50] value) mercuric chloride solution on the histomorphology of the innerlining of the air breathing organ (branchial diverticulum) of Heteropneustes fossilis has been described. The outer cell layers of the epithelial lining show cyclic necrosis leading to shedding with ultimate haemorrhage and drainage of blood into the lumen causing decrease in the number of blood islets. Simultaneously the epithelium regenerates causing hyperplasia of its cells and increased gas diffusion distance impairing normal aerial respiration. Also the number of foldings decreases and the secondary lamella like structures fuse together. This results in smoothening of the inner lining of the air sac. Later reappearance of the blood islets, secondary lamellae and foldings of the inner lining are observed along with the repair of the epithelium. Damage of the repaired inner lining follows again. (orig.)

  20. Life sciences

    Energy Technology Data Exchange (ETDEWEB)

    Day, L. (ed.)

    1991-04-01

    This document is the 1989--1990 Annual Report for the Life Sciences Divisions of the University of California/Lawrence Berkeley Laboratory. Specific progress reports are included for the Cell and Molecular Biology Division, the Research Medicine and Radiation Biophysics Division (including the Advanced Light Source Life Sciences Center), and the Chemical Biodynamics Division. 450 refs., 46 figs. (MHB)

  1. Life sciences

    International Nuclear Information System (INIS)

    Day, L.

    1991-04-01

    This document is the 1989--1990 Annual Report for the Life Sciences Divisions of the University of California/Lawrence Berkeley Laboratory. Specific progress reports are included for the Cell and Molecular Biology Division, the Research Medicine and Radiation Biophysics Division (including the Advanced Light Source Life Sciences Center), and the Chemical Biodynamics Division. 450 refs., 46 figs

  2. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer.

    Science.gov (United States)

    Lua, Pei Lin; Salihah, Noor; Mazlan, Nik

    2015-06-01

    To assess the efficacy of inhaled ginger aromatherapy on nausea, vomiting and health-related quality of life (HRQoL) in chemotherapy breast cancer patients. Single-blind, controlled, randomized cross-over study. Patients received 5-day aromatherapy treatment using either ginger essential oil or fragrance-matched artificial placebo (ginger fragrance oil) which was instilled in a necklace in an order dictated by the treatment group sequence. Two oncology clinics in the East Coast of Peninsular Malaysia. VAS nausea score, frequency of vomiting and HRQoL profile (EORTC QLQ-C30 scores). Sixty female patients completed the study (age=47.3±9.26 years; Malay=98.3%; on highly emetogenic chemotherapy=86.7%). The VAS nausea score was significantly lower after ginger essential oil inhalation compared to placebo during acute phase (P=0.040) but not sustained for overall treatment effect (treatment effect: F=1.82, P=0.183; time effect: F=43.98, Paromatherapy on vomiting [F(1, 58)=0.29, P=0.594]. However, a statistically significant change from baseline for global health status (Paromatherapy is an effective complementary therapy for CINV. The findings for HRQoL were however encouraging with significant improvement in several domains. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Early-life exposure to Tris(1,3-dichloroisopropyl) phosphate induces dose-dependent suppression of sexual behavior in male rats.

    Science.gov (United States)

    Kamishima, Manami; Hattori, Tatsuya; Suzuki, Go; Matsukami, Hidenori; Komine, Chiaki; Horii, Yasuyuki; Watanabe, Gen; Oti, Takumi; Sakamoto, Hirotaka; Soga, Tomoko; Parhar, Ishwar S; Kondo, Yasuhiko; Takigami, Hidetaka; Kawaguchi, Maiko

    2018-05-01

    Exposure to endocrine-disrupting chemicals may adversely affect animals, particularly during development. Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) is an organophosphate with anti-androgen function in vitro that is present in indoor dust at relatively high concentrations. In male rats, androgens are necessary for the development of reproductive organs, as well as the endocrine and central nervous systems. However, we currently do not know the exact effects of TDCIPP exposure through suckling on subsequent reproductive behavior in males. Here, we show that TDCIPP exposure (25-250 mg kg -1 via oral administration over 28 consecutive days post-birth) suppressed male sexual behavior and reduced testes size. These changes were dose-dependent and appeared first in adults rather than in juveniles. These results demonstrate that TDCIPP exposure led to normal body growth and appearance in juveniles, but disrupted the endocrine system and physiology in adults. Therefore, assays should be performed using adult animals to ensure accuracy, and to confirm the influence of chemical substances given during early mammalian life. Copyright © 2017 John Wiley & Sons, Ltd.

  4. Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats.

    Science.gov (United States)

    Kim, Jin Young; Lee, Jong-Ho; Kim, Doyun; Kim, Soung-Min; Koo, JaeHyung; Jahng, Jeong Won

    2015-01-01

    This study examined the effects of highly palatable food during adolescence on the psycho-emotional and neural disturbances caused by early life stress experience in female rats. Female Sprague-Dawley pups were separated from dam for 3 h daily during the first two weeks of birth (MS) or left undisturbed (NH). Half of MS females received free access to chocolate cookies in addition to ad libitum chow from postnatal day 28. Pups were subjected to the behavioral tests during young adulthood. The plasma corticosterone response to acute stress, ΔFosB and brain-derived neurotrophic factor (BDNF) levels in the brain regions were analyzed. Total caloric intake and body weight gain during the whole experimental period did not differ among the experimental groups. Cookie access during adolescence and youth improved anxiety-/depression-like behaviors by MS experience. ΔFosB expression was decreased, but BDNF was increased in the nucleus accumbens of MS females, and ΔFosB expression was normalized and BDNF was further increased following cookie access. Corticosterone response to acute stress was blunted by MS experience and cookie access did not improve it. Results suggest that cookie access during adolescence improves the psycho-emotional disturbances of MS females, and ΔFosB and/or BDNF expression in the nucleus accumbens may play a role in its underlying neural mechanisms.

  5. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure

    International Nuclear Information System (INIS)

    Boyd, Windy A.; Crocker, Tracey L.; Rodriguez, Ana M.; Leung, Maxwell C.K.; Wade Lehmann, D.; Freedman, Jonathan H.; Van Houten, Ben; Meyer, Joel N.

    2010-01-01

    We performed experiments to characterize the inducibility of nucleotide excision repair (NER) in Caenorhabditis elegans, and to examine global gene expression in NER-deficient and -proficient strains as well as germline vs. somatic tissues, with and without genotoxic stress. We also carried out experiments to elucidate the importance of NER in the adult life of C. elegans under genotoxin-stressed and control conditions. Adult lifespan was not detectably different between wild-type and NER-deficient xpa-1 nematodes under control conditions. However, exposure to 6 J/m 2 /day of ultraviolet C radiation (UVC) decreased lifespan in xpa-1 nematodes more than a dose of 100 J/m 2 /day in wild-type. Similar differential sensitivities were observed for adult size and feeding. Remarkably, global gene expression was nearly identical in young adult wild-type and xpa-1 nematodes, both in control conditions and 3 h after exposure to 50 J/m 2 UVC. Neither NER genes nor repair activity were detectably inducible in young adults that lacked germ cells and developing embryos (glp-1 strain). However, expression levels of dozens of NER and other DNA damage response genes were much (5-30-fold) lower in adults lacking germ cells and developing embryos, suggesting that somatic and post-mitotic cells have a much lower DNA repair ability. Finally, we describe a refinement of our DNA damage assay that allows damage measurement in single nematodes.

  6. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, Windy A. [Biomolecular Screening Branch, National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (United States); Crocker, Tracey L. [Nicholas School of the Environment, Duke University, Durham, NC 27708 (United States); Rodriguez, Ana M. [Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (United States); Leung, Maxwell C.K. [Nicholas School of the Environment, Duke University, Durham, NC 27708 (United States); Wade Lehmann, D. [Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (United States); Freedman, Jonathan H. [Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (United States); Van Houten, Ben [Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (United States); Meyer, Joel N., E-mail: joel.meyer@duke.edu [Nicholas School of the Environment, Duke University, Durham, NC 27708 (United States)

    2010-01-05

    We performed experiments to characterize the inducibility of nucleotide excision repair (NER) in Caenorhabditis elegans, and to examine global gene expression in NER-deficient and -proficient strains as well as germline vs. somatic tissues, with and without genotoxic stress. We also carried out experiments to elucidate the importance of NER in the adult life of C. elegans under genotoxin-stressed and control conditions. Adult lifespan was not detectably different between wild-type and NER-deficient xpa-1 nematodes under control conditions. However, exposure to 6 J/m{sup 2}/day of ultraviolet C radiation (UVC) decreased lifespan in xpa-1 nematodes more than a dose of 100 J/m{sup 2}/day in wild-type. Similar differential sensitivities were observed for adult size and feeding. Remarkably, global gene expression was nearly identical in young adult wild-type and xpa-1 nematodes, both in control conditions and 3 h after exposure to 50 J/m{sup 2} UVC. Neither NER genes nor repair activity were detectably inducible in young adults that lacked germ cells and developing embryos (glp-1 strain). However, expression levels of dozens of NER and other DNA damage response genes were much (5-30-fold) lower in adults lacking germ cells and developing embryos, suggesting that somatic and post-mitotic cells have a much lower DNA repair ability. Finally, we describe a refinement of our DNA damage assay that allows damage measurement in single nematodes.

  7. Solvothermal-induced 3D macroscopic SnO2/nitrogen-doped graphene aerogels for high capacity and long-life lithium storage.

    Science.gov (United States)

    Wang, Ronghua; Xu, Chaohe; Sun, Jing; Gao, Lian; Yao, Heliang

    2014-03-12

    3D macroscopic tin oxide/nitrogen-doped graphene frameworks (SnO2/GN) were constructed by a novel solvothermal-induced self-assembly process, using SnO2 colloid as precursor (crystal size of 3-7 nm). Solvothermal treatment played a key role as N,N-dimethylmethanamide (DMF) acted both as reducing reagent and nitrogen source, requiring no additional nitrogen-containing precursors or post-treatment. The SnO2/GN exhibited a 3D hierarchical porous architecture with a large surface area (336 m(2)g(-1)), which not only effectively prevented the agglomeration of SnO2 but also facilitated fast ion and electron transport through 3D pathways. As a result, the optimized electrode with GN content of 44.23% exhibited superior rate capability (1126, 855, and 614 mAh g(-1) at 1000, 3000, and 6000 mA g(-1), respectively) and extraordinary prolonged cycling stability at high current densities (905 mAh g(-1) after 1000 cycles at 2000 mA g(-1)). Electrochemical impedance spectroscopy (EIS) and morphological study demonstrated the enhanced electrochemical reactivity and good structural stability of the electrode.

  8. Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in a Drosophila Multiparent Population.

    Science.gov (United States)

    Stanley, Patrick D; Ng'oma, Enoch; O'Day, Siri; King, Elizabeth G

    2017-06-01

    The nutritional environments that organisms experience are inherently variable, requiring tight coordination of how resources are allocated to different functions relative to the total amount of resources available. A growing body of evidence supports the hypothesis that key endocrine pathways play a fundamental role in this coordination. In particular, the insulin/insulin-like growth factor signaling (IIS) and target of rapamycin (TOR) pathways have been implicated in nutrition-dependent changes in metabolism and nutrient allocation. However, little is known about the genetic basis of standing variation in IIS/TOR or how diet-dependent changes in expression in this pathway influence phenotypes related to resource allocation. To characterize natural genetic variation in the IIS/TOR pathway, we used >250 recombinant inbred lines (RILs) derived from a multiparental mapping population, the Drosophila Synthetic Population Resource, to map transcript-level QTL of genes encoding 52 core IIS/TOR components in three different nutritional environments [dietary restriction (DR), control (C), and high sugar (HS)]. Nearly all genes, 87%, were significantly differentially expressed between diets, though not always in ways predicted by loss-of-function mutants. We identified cis ( i.e. , local) expression QTL (eQTL) for six genes, all of which are significant in multiple nutrient environments. Further, we identified trans ( i.e. , distant) eQTL for two genes, specific to a single nutrient environment. Our results are consistent with many small changes in the IIS/TOR pathways. A discriminant function analysis for the C and DR treatments identified a pattern of gene expression associated with the diet treatment. Mapping the composite discriminant function scores revealed a significant global eQTL within the DR diet. A correlation between the discriminant function scores and the median life span ( r = 0.46) provides evidence that gene expression changes in response to diet are

  9. Extraterrestrial Life

    Science.gov (United States)

    Klein, M. J.

    1993-01-01

    Extraterrestrial Intelligence is intelligent life that developed somewhere other than the earth. Such life has not yet been discovered. However, scientific research, including astronomy, biology, planetary science and studies of fossils here on earth have led many scientists to conclude that such life may exist on planets orbiting at least some of the hundreds of billions of stars in our Milky Way Galaxy. Today, some researchers are trying to find evidence for extraterrestrial intelligence. This effort is often called SETI, which stands for Search for Extraterrestrial Intelligence. SETI researchers decided that looking for evidence of their technology might be the best way to discover other intelligent life in the Galaxy. They decided to use large radio telescopes to search the sky over a wide range of radio frequencies...

  10. Diet-induced developmental plasticity in life histories and energy metabolism in a beetle La dieta induce plasticidad del desarrollo en los rasgos de historia de vida y metabolismo energético en un escarabajo

    Directory of Open Access Journals (Sweden)

    SERGIO URREJOLA

    2011-12-01

    Full Text Available Adaptive phenotypic plasticity, has been recognized as an important strategy by which organisms maximize fitness in variable environments, which vary through development. A disassociation among stages should represent a null effect of the environment experienced during early ontogeny in the expression of adult traits. Food quality greatly influences survival, development and reproduction in many arthropod herbivores. We examined the effects of diet protein in physiological and life-history traits in the yellow mealworm beetle Tenebrio molitor through ontogeny. We established four experimental treatments: Low Protein (LP, Low Protein Control (LPC, High Protein (HP, and High Protein Control (HPC with recently eclosioned larvae each. Individuals were maintained on the same diet or transferred to the opposite diet for all pupae period and almost all adult period. Contrary to the expected, the duration of life-cycle, larval growth rate and body mass in T. molitor were similar in diet treatments. We found intra-individual trade-offs between environmental diet (rich or poor in protein content during larval phase and egg number. Larvae fed on a protein-deficient diet exhibited significantly higher respiratory rates than larvae fed on a rich protein diet. Compensatory feeding could act in T. molitor larvae indicating differences in metabolism but not in growth rate, body mass and life-cycle characteristics. Our results demonstrate the plasticity of reproductive and metabolic traits and life-cycle characteristics of T. molitor and how changes that occur in relation to diet can have profound effects on progeny and female fitness.La plasticidad fenotípica adaptativa ha sido reconocida como una estrategia importante por el cual los organismos maximizan su adecuación biológica en ambientes variables y la cual varía a lo largo del desarrollo. En los organismos la plasticidad fenotípica generalmente se refiere a como los diferentes tipos de rasgos pueden

  11. Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages.

    Science.gov (United States)

    Arcanjo, Caroline; Armant, Olivier; Floriani, Magali; Cavalie, Isabelle; Camilleri, Virginie; Simon, Olivier; Orjollet, Daniel; Adam-Guillermin, Christelle; Gagnaire, Béatrice

    2018-04-27

    Tritium ( 3 H) is a radioactive isotope of hydrogen. In the environment, the most common form of tritium is tritiated water (HTO). The present study aimed to identify early biomarkers of HTO contamination through the use of an aquatic model, the zebrafish (Danio rerio). We used the zebrafish embryo-larvae model to investigate the modes of action of HTO exposure at dose rates of 0.4 and 4 mGy/h, dose rates expected to induce deleterious effects on fish. Zebrafish were exposed to HTO from 3 hpf (hours post fertilization) to 96 hpf. The transcriptomic effects were investigated 24 h and 96 h after the beginning of the contamination, using mRNAseq. Results suggested an impact of HTO contamination, regardless of the dose rate, on genes involved in muscle contraction (tnnt2d, tnni2a.4, slc6a1a or atp2a1l) and eye opacity (crygm2d9, crygmxl1, mipb or lim2.3) after 24 h of contamination. Interestingly, an opposite differential expression was highlighted in genes playing a role in muscle contraction and eye opacity in 24 hpf embryos when comparing dose rates, suggesting an onset of DNA protective mechanisms. The expression of h2afx and ddb2 involved in DNA repair was enhanced in response to HTO exposure. The entrainment of circadian clock and the response to H 2 O 2 signalling pathways were enriched at 96 hpf at 0.4 mGy/h and in both stages after 4 mGy/h. Genes involved in ROS scavenging were differentially expressed only after 24 h of exposure for the lowest dose rate, suggesting the onset of early protective mechanisms against oxidative stress. Effects highlighted on muscle at the molecular scale were confirmed at a higher biological scale, as electron microscopy observations revealed sarcomere impairments in 96 hpf larvae for both dose rates. Together with other studies, the present work provides useful data to better understand modes of action of tritium on zebrafish embryos-larvae. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Recognising life

    DEFF Research Database (Denmark)

    Nissen, Morten

    2013-01-01

    ’ – that the contemporary discursive pragmatics of more or less pharmaceutical life practices still include forms of transcendence – and by the wish to fertilize the field of bio-politics with the indexical inter-subjectivity of the concept of ideology, as derived from an antiessentialist reading of Hegelian......–Marxist traditions. The analysis unfolds as an ideology critique that reconstructs, and seeks ways to overcome, particular forms of recognition that are identifiable in the data and in the field of drug practices, and how these form part of the constitution of singular collectives and participants – in these life...

  13. One life

    Directory of Open Access Journals (Sweden)

    Demkova E.E.

    2016-06-01

    Full Text Available It is not easy to care for a special needs child. Especially, it is easy to understand parents’ worries about their grown up children. Living in one’s own family or supported living in the community are much more preferable than the options the state can offer. The author — a mother of a young woman with autism — contemplates about possibilities for independent living for a person with special needs after their parents are gone. She is confident that teaching a child skills for independent living is not less important than giving them school education. The author illustrates her thoughts with real examples of support for adults with disabilities in their independent life or life in a foster family in a city, as well in rural areas.

  14. Pumping life

    DEFF Research Database (Denmark)

    Sitsel, Oleg; Dach, Ingrid; Hoffmann, Robert Daniel

    2012-01-01

    The name PUMPKIN may suggest a research centre focused on American Halloween traditions or the investigation of the growth of vegetables – however this would be misleading. Researchers at PUMPKIN, short for Centre for Membrane Pumps in Cells and Disease, are in fact interested in a large family o......’. Here we illustrate that the pumping of ions means nothing less than the pumping of life....

  15. Loperamide Induced Life Threatening Ventricular Arrhythmia

    Directory of Open Access Journals (Sweden)

    Ankit Upadhyay

    2016-01-01

    Full Text Available Loperamide is over-the-counter antidiarrheal agent acting on peripherally located μ opioid receptors. It is gaining popularity among drug abusers as opioid substitute. We report a case of a 46-year-old male that was presented after cardiac arrest. After ruling out ischemia, cardiomyopathy, pulmonary embolism, central nervous system pathology, sepsis, and other drug toxicity, we found out that patient was using around 100 mg of Loperamide to control his chronic diarrhea presumably because of irritable bowel syndrome for last five years and consumed up to 200 mg of Loperamide daily for last two days before the cardiac arrest. We hypothesize that the patient’s QTc prolongation and subsequent cardiac arrest are due to Loperamide toxicity. Patient experienced gradual resolution of tachyarrhythmia and gradual decrease in QTc interval during hospitalization which supports the evidence of causal relationship between Loperamide overdose and potentially fatal arrhythmias. It also provided the clue that patient may have congenital long QT syndrome which was unmasked by Loperamide causing ventricular arrhythmias. This case adds one more pearl in the literature to support that Loperamide overdose related cardiac toxicity does exist and it raises concerns over Loperamide abuse in the community.

  16. EXTRA LIFE

    Directory of Open Access Journals (Sweden)

    Ruth S. Contreras Espinosa

    2016-02-01

    Full Text Available El creciente número de personas jugando videojuegos significa que estos están teniendo un efecto innegable sobre nuestra cultura. Este efecto es claramente visible en una aceptación general. Los videojuegos también han cambiado la forma en que muchas otras formas de medios de comunicación, se producen y consumen. Los videojuegos tienen una influencia creciente en nuestra cultura, y en "EXTRA LIFE" diferentes autores expresan sus opiniones sobre este nuevo medio. EXTRA LIFE Abstract The increasing number of people playing video games means that they are having an undeniable effect on culture. This effect is clearly visible in the increasing mainstream acceptance of aspects of gaming culture. Video games have also changed the way that many other forms of media, are produced and consumed. Video games have an increasing influence on our culture,  and in "EXTRA LIFE" diferent authors have voiced their opinions on this new media. Keywords: Video games; culture; effects; games.

  17. Life lessons.

    Science.gov (United States)

    Nitschke, Jonathan R

    2015-01-01

    Reminiscing about his younger self: "I mean I can't very well just 86 [in American slang, to "86" is to eject, remove, or discard someone or something, J.R.N.] this guy from my life. On the other hand, if through some as yet undeveloped technology I were to run into him today, how comfortable would I feel about lending him money, or for that matter even stepping down the street to have a beer and talk over old times?" - Thomas Pynchon, Slow Learner.

  18. Lake Roosevelt Fisheries Monitoring Progam; Thyroid-Induced Chemical Imprinting in Early Life Stages and Assessment of Smoltification in Kokanee Salmon Implications for Operating Lake Roosevelt Kokanee Salmon Hatcheries; 1993 Supplement Report.

    Energy Technology Data Exchange (ETDEWEB)

    Tilson, Mary Beth; Galloway, Heather; Scholz, Allan T. (Eastern Washington University, Upper Columbia United Tribes Fisheries Research Center, Cheney, WA)

    1994-06-01

    In 1991, two hatcheries were built to provide a kokanee salmon and rainbow trout fishery for Lake Roosevelt as partial mitigation for the loss of anadromous salmon and steelhead caused by construction of Grand Coulee Dam. The Sherman Creek Hatchery, located on a tributary of Lake Roosevelt to provide an egg collection and imprinting site, is small with limited rearing capability. The second hatchery was located on the Spokane Indian Reservation because of a spring water source that supplied cold, pure water for incubating and rearing eggs.`The Spokane Tribal Hatchery thus serves as the production facility. Fish reared there are released into Sherman Creek and other tributary streams as 7-9 month old fry. However, to date, returns of adult fish to release sites has been poor. If hatchery reared kokanee imprint to the hatchery water at egg or swim up stages before 3 months of age, they may not be imprinting as 7-9 month old fry at the time of stocking. In addition, if these fish undergo a smolt phase in the reservoir when they are 1.5 years old, they could migrate below Grand Coulee Dam and out of the Lake Roosevelt system. In the present investigation, which is part of the Lake Roosevelt monitoring program to assess hatchery effectiveness, kokanee salmon were tested to determine if they experienced thyroxine-induced chemical imprinting and smoltification similar to anadromous salmonids. Determination of the critical period for olfactory imprinting was determined by exposing kokanee to different synthetic chemicals (morpholine or phenethyl alcohol) at different life stages, and then measuring the ability to discriminate the chemicals as sexually mature adults. Whole body thyroxine content and blood plasma thyroxine concentration was measured to determine if peak thyroid activity coincided with imprinting or other morphological, physiological or behavioral transitions associated with smoltification.

  19. Induced Abortion

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Induced Abortion Home For Patients Search FAQs Induced Abortion Page ... Induced Abortion FAQ043, May 2015 PDF Format Induced Abortion Special Procedures What is an induced abortion? What ...

  20. Inducing Lactation: Breastfeeding for Adoptive Moms

    Science.gov (United States)

    ... Dynamics > Adoption & Foster Care > Inducing Lactation: Breastfeeding for Adoptive Moms Family Life Listen Español Text Size Email Print Share Inducing Lactation: Breastfeeding for Adoptive Moms Page Content Article Body A growing number ...

  1. Personel and life coaching

    DEFF Research Database (Denmark)

    Spaten, Ole Michael

    2018-01-01

    Personal coaching and life-coaching psychology is for assisting individuals clarify values, visions and meaning of life, through a systematic process in which the coach facilitates improvement of satisfying and fruitful life experiences and achievement of personal life goals....

  2. Ectopic hTERT expression extends the life span of human CD4(+) helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis

    NARCIS (Netherlands)

    Luiten, Rosalie M.; Péne, Jérome; Yssel, Hans; Spits, Hergen

    2003-01-01

    Human somatic cells have a limited life span in vitro. Upon aging and with each cell division, shortening of telomeres occurs, which eventually will lead to cell cycle arrest. Ectopic hTERT expression has been shown to extend the life span of human T cells by preventing this telomere erosion. In the

  3. The Greenlandic Life Script and Life Stories

    DEFF Research Database (Denmark)

    Zaragoza Scherman, Alejandra; Berntsen, Dorthe

    Adults older than 40 years remember a significantly greater amount of personal life events from their 15 - 30 years of age. This phenomenon is known as the reminiscence bump (Rubin, Rahal, & Poon, 1998). The reminiscence bump is highly populated by emotionally positive events (Rubin & Berntsen......, 2003), when cued by requests for important events. This dominance of positive events is not seen when cued by random words. Berntsen and Rubin (2004) presented a cultural explanation for the bump: cultural life script theory. Their theory claims that the bump for the life story can be explained...... by the life script; that is, culturally shared expectations about the order and timing of life events in an typical, idealized life course. According to the cultural life script theory, the life script is used as a guideline for the recall of autobiographical memories, which help construct personal life...

  4. Predation Risk versus Pesticide Exposure: Consequences of Fear and Loathing in the Life of Stream Shredders

    Science.gov (United States)

    Pestana, J. T.; Baird, D. J.; Soares, A. M.

    2005-05-01

    Stream invertebrates are exposed to complex stressor regimes including both biotic and abiotic factors. Species living in streams in agricultural landscapes are often subjected to episodic or continuous exposures to low levels of agrochemicals, which may approach or exceed specific substance guidelines. Sublethal effects of pesticides may result in direct effects on organisms (e.g. reduced physiological performance), which may in turn contribute to indirect effects relating to survival (e.g. increased predation risk). Here, we investigate the possibility that predator-release kairomones can act additively with low-level pesticide exposure to reduce physiological performance and survival of stream invertebrates in previously unforeseen ways. Feeding, metabolic and behavioural responses of two shredder insects, the North American stonefly Pteronarcys comstockii and the European caddisfly Sericostoma vittatum were measured under exposure to the insecticide imidacloprid at different levels of indirect predation stress using predator-release kairomones from Brown Trout (Salmo trutta). Pteronarcys feeding was measured in terms of mass of naturally conditioned alder leaf discs consumed over a 6-day and 10 -day period in animals held in cages in stream mesocosms. Pteronarcys feeding was impaired at 1 ppb in the 6-day trial and at 0,5 ppb in the 10-day trial relatively to unexposed controls. Metabolic rate was measured in the lab in terms of oxygen consumption of Pteronarcys. Animals exposed to 0.5 and 1 ppb imidacloprid showed elevated respiratory rates compared to controls. Laboratory experiments with Sericostoma, currently in progress, are examining the separate and combined effects of imidacloprid and predator kairomone on similar endpoints. These preliminary results are discussed in relation to the development of the Mechanistic Unifying Stressor Effects (MUSE) model which can be used to predict combined ecological effects of multiple stressors at the population level.

  5. Managing Daily Life

    Science.gov (United States)

    ... Duchenne / Managing Daily Life Print Email Managing Daily Life Environmental accessibility As the person with Duchenne starts ... such as wider doorways and ramps, can make life easier once the person with Duchenne cannot climb ...

  6. The impact of hearing impairment and noise-induced hearing injury on quality of life in the active-duty military population: challenges to the study of this issue.

    Science.gov (United States)

    Alamgir, Hasanat; Turner, Caryn A; Wong, Nicole J; Cooper, Sharon P; Betancourt, Jose A; Henry, James; Senchak, Andrew J; Hammill, Tanisha L; Packer, Mark D

    2016-01-01

    The objectives of this research were to 1) summarize the available evidence on the impact of hearing loss on quality of life (QOL) among U.S. active-duty service members, 2) describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life, 3) examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members, and 4) provide recommendations for future studies that seek to quantify the impact of hearing loss in this population. There is a lack of literature that addresses the intersection of hearing impairment, the military population, and quality of life measures. For audiological research, U.S. military personnel offer a unique research population, as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these conditions. Our team recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.

  7. Defending definitions of life.

    Science.gov (United States)

    Mix, Lucas John

    2015-01-01

    Over the past 10 years, it has become unpopular to talk about definitions of life, under the assumption that attempts at a precise definition are counterproductive. Recent attempts have failed to meet strict philosophical criteria for definitions and have failed to reach consensus. I argue that provisional definitions are necessary for clear communications. Our current knowledge of biology justifies a number of universal claims about the category of life. Whether or not "life" represents a natural category, it maps to a number of important, observable processes. Given the importance of those processes and the extent of our knowledge, plural explicit definitions of life (and related categories) will be necessary for progress in astrobiology and origin-of-life studies as well as biology in general. I propose concrete categories related to, but not necessarily coextensive with, life for clear communication and hypothesis formation: Woese life, Darwin life, Haldane life.

  8. Life Stories and Trauma

    DEFF Research Database (Denmark)

    Kongshøj, Inge Lise Lundsgaard; Bohn, Annette; Berntsen, Dorthe

    Research has shown a connection between Posttraumatic Stress Disorder (PTSD) and integration of traumatic experiences into the life story. Furthermore, empirical evidence suggests that life story formation begins in mid to late adolescence. Following these findings, the present study investigated...... whether experiencing trauma in youth was associated with a greater risk to integrate the trauma into the life story compared to adult traumatic exposure. Life stories were collected from 115 participants recruited via Amazon Mechanical Turk. Moreover, participants filled out questionnaires regarding...... often integrate the trauma into their life story? Results will be discussed in relation to theories of development of life stories and of PTSD....

  9. Architecture is Life... ...Life is Architecture

    OpenAIRE

    Snider, David E

    2001-01-01

    When thinking about architecture, I cannot help but think about my life and the things that have affected my life. How does the environment around us effect the daily decisions we make? How do the experiences throughout our life impact who we are and who we become? The people and surroundings we choose will ultimately decide the type of people we become. When we select our surroundings we are in turn selecting our ideal community. Everyone is trying to achieve community in some sense, from in...

  10. Go4Life

    Medline Plus

    Full Text Available ... This item has been hidden Go4Life Exercises — Building Strength Play all Try some of these Go4Life exercises to improve your strength! Stronger muscles can make it easier to do ...

  11. Life cycle assessment (LCA)

    DEFF Research Database (Denmark)

    Thrane, Mikkel; Schmidt, Jannick Andresen

    2004-01-01

    The chapter introduces Life Cycle Assessment (LCA) and its application according to the ISO 1404043 standards.......The chapter introduces Life Cycle Assessment (LCA) and its application according to the ISO 1404043 standards....

  12. Go4Life

    Medline Plus

    Full Text Available ... useful upper body exercise from Go4Life, the Overhead Arm Raise. CC 3:10 Play next Play now Go4Life Exercise--Hand Grip - Duration: 3 minutes, 10 seconds. National Institute ...

  13. YOUR LIFE@CERN

    CERN Multimedia

    Guinot, Genevieve

    2016-01-01

    Balancing work and home life, getting support for your family and thriving in an inclusive and respectful workplace: find out more about the support structures in place to enhance your working life@CERN!

  14. Go4Life

    Medline Plus

    Full Text Available ... more This item has been hidden Go4Life Exercises — Balance Play all Try some of these Go4Life exercises to improve your balance! Balance is important because it can help reduce ...

  15. Study of the desintegration of short-life fission products. Application to the mass distribution in the fission of 238U and 233U induced by 14MeV neutrons

    International Nuclear Information System (INIS)

    Cavallini, Pierre.

    1975-01-01

    Nuclear spectrometry of short-life fission products was investigated, together with direct applications to the study of mass and charge distribution in fission reactions. It is shown that, by choosing judiciously the target in which the fission product is created and owing to the differences in stabilities and evaporation temperatures of the compounds obtained, it is possible to separate some elements. For example, niobium was separated by heating after irradiation of a mixture of UC and RuCl 3 , and sublimation in a tube with temperature gradient. It was thus possible to study the 99 Nb isotope. Other classical chemical separation processes were used for yttrium and strontium. The half-lifes beta and gamma spectra, decay schemes of 93 Sr, 94 Y and 95 Y were studied. It was shown how to obtain mass distribution in fission using a nondestructive gamma analysis method. As an application, results obtained in the fission of 233 U and 238 U at 14 MeV are given [fr

  16. End of Life Issues

    Science.gov (United States)

    Planning for the end of life can be difficult. But by deciding what end-of-life care best suits your needs when you are healthy, you can ... right choices when the time comes. End-of-life planning usually includes making choices about the following: ...

  17. Chinese Student Life.

    Science.gov (United States)

    Braswell, James; Boone, Jerry N.

    1991-01-01

    Places life of university students in China in context of Tiananmen Square and Cultural Revolution, with implications of serving them as students in the United States. Presents basic facts of student life in China. Although the emphasis is on college life, some attention is paid to earlier student experiences as well. (Author/NB)

  18. Go4Life

    Medline Plus

    Full Text Available ... Go4Life Exercises — Stretching Play all Try some of these Go4Life exercises to improve your flexibility! 2:48 ... Exercises — Building Strength Play all Try some of these Go4Life exercises to improve your strength! Stronger muscles ...

  19. Life Cycle Management

    DEFF Research Database (Denmark)

    Bey, Niki

    2018-01-01

    This chapter gives an overview of Life Cycle Management (LCM)—a discipline that deals with the managerial tasks related to practicing sustainable development in an organisation . Just as Life Cycle Assessment, LCM advocates the life cycle perspective , and it applies this perspective in decision...

  20. Go4Life

    Medline Plus

    Full Text Available ... some of these Go4Life exercises to improve your flexibility! 2:48 Play next Play now Go4Life Exercise-- ... 17,679 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. CC 1: ...

  1. Work–Life Interventions

    OpenAIRE

    He Lu Calvin Ong; Senthu Jeyaraj

    2014-01-01

    Despite disparities in the conceptualization of work–life balance (WLB) and work–life harmony (WLH) in the literature, there remains no evidence till date to validate these differences. Furthermore, there are currently no insights that shed light on the relationship between work–life initiatives and key business strategies of contemporary organizations. Hence, the current study investigated the differences between the ...

  2. Life in other planets

    International Nuclear Information System (INIS)

    Ghosh, S.N.

    1977-01-01

    Speculations of life on other planets in space are discussed. The life history of a star in terms of the high temperature fusion reactions taking place in it, is outlined. The phenomenon of gases escaping from planetary atmospheres which destroys life on them is explained. Solar radiation effects, pulsar detection etc. are briefly touched upon. (K.B.)

  3. Life in other planets

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, S N [Calcutta Univ. (India). Dept. of Applied Physics

    1977-12-01

    Speculations of life on other planets in space are discussed. The life history of a star in terms of the high-temperature fusion reactions taking place in it is outlined. The phenomenon of gases escaping from planetary atmospheres which destroys life on them is explained. Solar radiation effects, pulsar detection, etc., are briefly touched upon.

  4. Quality of Life

    Science.gov (United States)

    Military Child Education DSN: (315) 477-9422 COMM: (808) 477-9422 Individual Contacts Branch Chief, Quality Directory Media Inquiries Home : Resources : Quality of Life J102 Quality of Life and Military Child Education Branch PACOM Quality of Life and Education Facebook Page | USPACOM SAPR 24/7 Emergency Lines and

  5. The Use of Monoterpenes as Kairomones by Ips latidens (LeConte) (Coleoptera: Scolytidae)

    Science.gov (United States)

    D.R. Miller; J.H. Borden

    1990-01-01

    The responses of Ips lutidens (LeConte) to multiple-funnel traps baited with various monoterpenes were determined in stands of lodgepole pine in British Columbia. ß-Phellandrene was attractive to I. lutidens in the absence of the pheromone ipsenol ß-Phellandrene increased the attraction of I. lutidens to...

  6. Costly defense in a fluctuating environment-sensitivity of annual Nothobranchius fishes to predator kairomones

    Czech Academy of Sciences Publication Activity Database

    Polačik, Matej; Janáč, Michal

    2017-01-01

    Roč. 7, č. 12 (2017), s. 4289-4298 ISSN 2045-7758 R&D Projects: GA ČR(CZ) GBP505/12/G112 Institutional support: RVO:68081766 Keywords : Clarias * diapause * embryo * olfactory cue * tilapia Subject RIV: EG - Zoology OBOR OECD: Ecology Impact factor: 2.440, year: 2016

  7. Change in phenotypic plasticity of a morphological defence in Daphnia galeata (Crustacea: Cladocera in a selection experiment

    Directory of Open Access Journals (Sweden)

    Koichi FUJII

    2007-08-01

    Full Text Available Some water fleas Daphnia change their head morphology to reduce predation risk in response to chemical substances (kairomones released from larvae of the invertebrate predator Chaoborus (Insecta: Diptera. We tested for evidence of the costs associated with elongation of the head spine in Daphnia galeata and the consequences of these costs on the inducibility of head spine elongation in predictable and unpredictable environments. We exposed D. galeata in outdoor experimental ponds to conditions under which predation pressure by Chaoborus larvae and the concentration of kairomones from this predator were controlled for about 70 days. In the laboratory, we then used Daphnia clones collected from the outdoor ponds to investigate the inducibility of head spine formation in response to Chaoborus kairomones. The inducibility of head spine formation increased in D. galeata from the ponds that had contained both predators and kairomones, whereas in water fleas from the ponds containing only kairomones the plasticity (inducibility of head spine formation decreased compared with that in the control ponds. These results suggest that the production of a defensive head spine, its phenotypic plasticity, or both entail some costs. Contrary to our predictions, exposure to Chaoborus kairomones in the laboratory resulted in head lengths that were not significantly different among any of the clones from the three outdoor treatments. We found no evidence for costs associated with head spine elongation in terms of fecundity, time to maturity, or intrinsic rate of natural population increase. Average within-clone partial correlations calculated for head length and intrinsic rate of natural population increase, corrected for body length, were not significantly negative, indicating no cost of defence. This was probably because food conditions in the laboratory were so good that the costs of defence could not be detected. Furthermore, community-level changes, such as

  8. NPP service life management

    International Nuclear Information System (INIS)

    Elagin, Yu.P.

    2001-01-01

    Problems of NPP service life management and service life prolongation are reviewed. Methods for the prolongation of the French NPP service life are discussed, priority directions of nuclear block service life management in regard to aging in the context of the European program of investigation into the materials aging are identified. Questions of the provision of the 60 years service life of the Mihama 1 block (Japan) and decision of the problem of the control equipment aging in Great Britain are discussed. Situation with the prolongation of licenses on the NPP operation in the USA and Spain is considered [ru

  9. Life is pretty meaningful.

    Science.gov (United States)

    Heintzelman, Samantha J; King, Laura A

    2014-09-01

    The human experience of meaning in life is widely viewed as a cornerstone of well-being and a central human motivation. Self-reports of meaning in life relate to a host of important functional outcomes. Psychologists have portrayed meaning in life as simultaneously chronically lacking in human life as well as playing an important role in survival. Examining the growing literature on meaning in life, we address the question "How meaningful is life, in general?" We review possible answers from various psychological sources, some of which anticipate that meaning in life should be low and others that it should be high. Summaries of epidemiological data and research using two self-report measures of meaning in life suggest that life is pretty meaningful. Diverse samples rate themselves significantly above the midpoint on self-reports of meaning in life. We suggest that if meaning in life plays a role in adaptation, it must be commonplace, as our analysis suggests. (c) 2014 APA, all rights reserved.

  10. Best Practice Life Expectancy

    DEFF Research Database (Denmark)

    Medford, Anthony

    2017-01-01

    been reported previously by various authors. Though remarkable, this is simply an empirical observation. Objective: We examine best-practice life expectancy more formally by using extreme value theory. Methods: Extreme value distributions are fit to the time series (1900 to 2012) of maximum life......Background: Whereas the rise in human life expectancy has been extensively studied, the evolution of maximum life expectancies, i.e., the rise in best-practice life expectancy in a group of populations, has not been examined to the same extent. The linear rise in best-practice life expectancy has...... expectancies at birth and age 65, for both sexes, using data from the Human Mortality Database and the United Nations. Conclusions: Generalized extreme value distributions offer a theoretically justified way to model best-practice life expectancies. Using this framework one can straightforwardly obtain...

  11. Rules of Thumb in Life-Cycle Saving Decisions

    OpenAIRE

    Winter, Joachim; Schlafmann, Kathrin; Rodepeter, Ralf

    2011-01-01

    We analyse life-cycle saving decisions when households use simple heuristics, or rules of thumb, rather than solve the underlying intertemporal optimization problem. We simulate life-cycle saving decisions using three simple rules and compute utility losses relative to the solution of the optimization problem. Our simulations suggest that utility losses induced by following simple decision rules are relatively low. Moreover, the two main saving motives re ected by the canonical life-cyc...

  12. Induced Seismicity

    Science.gov (United States)

    Keranen, Katie M.; Weingarten, Matthew

    2018-05-01

    The ability of fluid-generated subsurface stress changes to trigger earthquakes has long been recognized. However, the dramatic rise in the rate of human-induced earthquakes in the past decade has created abundant opportunities to study induced earthquakes and triggering processes. This review briefly summarizes early studies but focuses on results from induced earthquakes during the past 10 years related to fluid injection in petroleum fields. Study of these earthquakes has resulted in insights into physical processes and has identified knowledge gaps and future research directions. Induced earthquakes are challenging to identify using seismological methods, and faults and reefs strongly modulate spatial and temporal patterns of induced seismicity. However, the similarity of induced and natural seismicity provides an effective tool for studying earthquake processes. With continuing development of energy resources, increased interest in carbon sequestration, and construction of large dams, induced seismicity will continue to pose a hazard in coming years.

  13. The essence of life.

    Science.gov (United States)

    Ma, Wentao

    2016-09-26

    Although biology has achieved great successes in recent years, we have not got a clear idea on "what is life?" Actually, as explained here, the main reason for this situation is that there are two completely distinct aspects for "life", which are usually talked about together. Indeed, in respect to these two aspects: Darwinian evolution and self-sustaining, we must split the concept of life correspondingly, for example, by defining "life form" and "living entity", separately. For life's implementation (related to the two aspects) in nature, three mechanisms are crucial: the replication of DNA/RNA-like polymers by residue-pairing, the sequence-dependent folding of RNA/protein-like polymers engendering special functions, and the assembly of phospholipid-like amphiphiles forming vesicles. The notion "information" is significant for us to comprehend life phenomenon: the life form of a living entity can just be defined by its genetic information; Darwinian evolution is essentially an evolution of such information, transferred across generations. The in-depth analysis concerning the essence of life would improve our cognition in the whole field of biology, and may have a direct influence on its subfields like the origin of life, artificial life and astrobiology. This article was reviewed by Anthony Poole and Thomas Dandekar.

  14. Artificial life and Piaget.

    Science.gov (United States)

    Mueller, Ulrich; Grobman, K H.

    2003-04-01

    Artificial life provides important theoretical and methodological tools for the investigation of Piaget's developmental theory. This new method uses artificial neural networks to simulate living phenomena in a computer. A recent study by Parisi and Schlesinger suggests that artificial life might reinvigorate the Piagetian framework. We contrast artificial life with traditional cognitivist approaches, discuss the role of innateness in development, and examine the relation between physiological and psychological explanations of intelligent behaviour.

  15. The government of life

    DEFF Research Database (Denmark)

    Villadsen, Kaspar; Wahlberg, Ayo

    2015-01-01

    . Subsequent research on biopolitics and governmentality has tended to separate the concepts, differentiating into distinct research traditions each with different intellectual pathways. We propose to bring these conceptual innovations together to understand contemporary problems of the government of life...... of death power, the interplay of sovereignty, discipline and security, governmentalization through medical normalization, and ‘securitization’ of life as circulations and open series. The article also introduces this special feature on the government of life in which significant scholars explores issues...

  16. Life Span Developmental Approach

    OpenAIRE

    Ali Eryilmaz

    2011-01-01

    The Life Span Developmental Approach examines development of individuals which occurs from birth to death. Life span developmental approach is a multi-disciplinary approach related with disciplines like psychology, psychiatry, sociology, anthropology and geriatrics that indicates the fact that development is not completed in adulthood, it continues during the life course. Development is a complex process that consists of dying and death. This approach carefully investigates the development of...

  17. The quantum life

    Science.gov (United States)

    Davies, Paul

    2009-07-01

    To a physicist, life seems little short of miraculous-all those stupid atoms getting together to perform such clever tricks! For centuries, living organisms were regarded as some sort of magic matter. Today, we know that no special "life force" is at work in biology; there is just ordinary matter doing extraordinary things, all the while obeying the familiar laws of physics. What, then, is the secret of life's remarkable properties?

  18. Life insurance mathematics

    CERN Document Server

    Gerber, Hans U

    1997-01-01

    This concise introduction to life contingencies, the theory behind the actuarial work around life insurance and pension funds, will appeal to the reader who likes applied mathematics. In addition to model of life contingencies, the theory of compound interest is explained and it is shown how mortality and other rates can be estimated from observations. The probabilistic model is used consistently throughout the book. Numerous exercises (with answers and solutions) have been added, and for this third edition several misprints have been corrected.

  19. Work-Life Balance

    OpenAIRE

    Kvasničková, Katarína

    2011-01-01

    The subject of this thesis is Work-Life Balance - the reconciliation of professional and personal lives. The primary objective of this work is to analyze employee satisfaction in achieving a balance between the professional and personal life and to develop recommendations for employer on that basis. The theoretical portion of this work defines the issues surrounding Work-Life Balance and tools that employees can use to harmonize the two with an analysis of applications in the Czech Republic a...

  20. Early Life Exposures and Cancer

    Science.gov (United States)

    Early-life events and exposures have important consequences for cancer development later in life, however, epidemiological studies of early-life factors and cancer development later in life have had significant methodological challenges.

  1. Life as quale

    Directory of Open Access Journals (Sweden)

    Roland Cazalis

    2013-07-01

    Full Text Available The developments of relational biology during these last thirty years tend to classify autonomous system such as biological, cognitive or social groups among the living systems which they models as such. This present article tries to understand the nature of life by the transition phase which characterizes the passage from the inanimate world to the organic one. Our proposal is that life belongsto the category of qualia. Consequently, qualia are already obvious at least with the simplest forms of the living world. Furthermore, if life, consciousness and language are emergences of complex entities,life as quale is specifically the self of the cellular organism.

  2. Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of a Nonrandomized Prospective Study Using a Standardized Follow-Up Program

    International Nuclear Information System (INIS)

    Vergeer, Marije R.; Doornaert, Patricia A.H.; Rietveld, Derek H.F.; Leemans, C. Rene; Slotman, Ben J.; Langendijk, Johannes A.

    2009-01-01

    Purpose: The purpose of this study was to compare intensity-modulated radiation therapy (IMRT) and three-dimensional conventional radiotherapy (3D-CRT) with regard to patient-rated xerostomia, Radiation Therapy Oncology Group (RTOG) acute and late xerostomia and health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma (HNSCC). Methods and Materials: Included were 241 patients with HNSCC treated with bilateral irradiation ± chemotherapy. Since 2000, all patients treated with HNSCC were included in a program, which prospectively assessed acute and late morbidity according to the RTOG and HRQoL on a routine basis at regular intervals. Before October 2004, all patients were treated with 3D-CRT (N = 150). After clinical implementation in October 2004, 91 patients received IMRT. In this study, the differences regarding RTOG toxicity, xerostomia, and other items of HRQoL were analyzed. Results: The use of IMRT resulted in a significant reduction of the mean dose of the parotid glands (27 Gy vs. 43 Gy (p < 0.001). During radiation, Grade 2 RTOG xerostomia was significantly less with IMRT than with 3D-CRT. At 6 months, the prevalence of patient-rated moderate to severe xerostomia and Grade 2 or higher RTOG xerostomia was significantly lower after IMRT versus 3D-CRT. Treatment with IMRT also had a positive effect on several general and head and neck cancer-specific HRQoL dimensions. Conclusions: IMRT results in a significant reduction of patient- and observer-rated xerostomia, as well as other head and neck symptoms, compared with standard 3D-CRT. These differences translate into a significant improvement of the more general dimensions of HRQoL.

  3. Life Is Hard But Life Is Good

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Cancer, paralysis, the death of her loved ones...Lei Juli has experienced more unexpected suffering than most other people. She was once in despair, but she managed to overcome all of these catastrophes. She tells the world what her experience has taught her: Love the life you’re given.

  4. Curcuma alismatifolia vase life

    DEFF Research Database (Denmark)

    Trevenzoli Favero, Bruno; Pace Pereira Lima, Giuseppina; Dole, John

    2017-01-01

    Cut curcuma stem has a reported vase life of 7 to 21 days and this difference in vase life is probably due to a combination of different factors such as growing conditions and postharvest treatments. However, the cut flower industry needs key postharvest information for new species and cultivars ...

  5. Partying as Everyday Life

    DEFF Research Database (Denmark)

    Demant, Jakob; Østergaard, Jeanette

    2007-01-01

    situates the event in everyday life. By drawing on Maffesoli's (1996) concept of ‘sociality' and Lincoln's (2005) concept of zoning the spatial and social logic of the house, partying is analysed using both qualitative and quantitative material. The analysis suggests that the consumption of alcohol (i...... to reaffirm friendship and is therefore an integrated part of adolescents' everyday life.  ...

  6. Go4Life

    Medline Plus

    Full Text Available ... now Alzheimer's Disease-Related Dementias: Research Challenges and Opportunities - Duration: 5 minutes, 32 seconds. National Institute On ... This item has been hidden Go4Life Exercises — Building Strength Play all Try some of these Go4Life exercises ...

  7. Quality of life technologies

    DEFF Research Database (Denmark)

    Wac, Katarzyna; Fiordelli, M.; Gustarini, M.

    2015-01-01

    Inevitably, as basic human needs are assured in any developed society, differentiating factors for quality of life (QoL) relate to a greater capacity to make informed decisions across daily life activities, especially those related to health. The availability of powerful, personalized, and wearable...

  8. Life cycle management (LCM)

    DEFF Research Database (Denmark)

    Remmen, Arne; Thrane, Mikkel

    2004-01-01

    The chapter gives an introduction to Life Cycle Management (LCM) and shows how LCM can be practiced in different contexts and at different ambition levels.......The chapter gives an introduction to Life Cycle Management (LCM) and shows how LCM can be practiced in different contexts and at different ambition levels....

  9. A Life in Words

    DEFF Research Database (Denmark)

    Siegumfeldt, Inge Birgitte; Auster, Paul

    "Paul Auster's A Life in Words--a wide-ranging dialogue between Auster and the Danish professor I.B. Siegumfeldt--is a remarkably candid and often surprising celebration of one writer's art, craft, and life. It includes many revelations that have never been shared before, such as that he doesn...

  10. Go4Life

    Medline Plus

    Full Text Available ... all Try some of these Go4Life exercises to improve your flexibility! 2:48 Play next Play now ... all Try some of these Go4Life exercises to improve your strength! Stronger muscles can make it easier ...

  11. ICTs and Political Life.

    Science.gov (United States)

    Robbin, Alice; Courtright, Christina; Davis, Leah

    2004-01-01

    Presents a literature review that covers the following topics related to information and communications technologies (ICTs): (1) theories of ICTs and how they frame political life; (2) normative democratic theory and concepts; (3) e-political life; and (4) research on e-government, e-governance, and e-democracy; (Contains 276 references.) (MES)

  12. Thermostable Shelf Life Study

    Science.gov (United States)

    Perchonok, M. H.; Antonini, D. K.

    2008-01-01

    The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

  13. Thermostabilized Shelf Life Study

    Science.gov (United States)

    Perchonok, Michele H.; Catauro, Patricia M.

    2009-01-01

    The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

  14. Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.; Hauschild, Michael Zwicky; Boulay, Anne-Marie

    2018-01-01

    This chapter is dedicated to the third phase of an LCA study, the Life Cycle Impact Assessment (LCIA) where the life cycle inventory’s information on elementary flows is translated into environmental impact scores. In contrast to the three other LCA phases, LCIA is in practice largely automated...

  15. Life sciences report 1987

    Science.gov (United States)

    1987-01-01

    Highlighted here are the major research efforts of the NASA Life Sciences Division during the past year. Topics covered include remote health care delivery in space, space biomedical research, gravitational biology, biospherics (studying planet Earth), the NASA Closed Ecological Life Support System (CELSS), exobiology, flight programs, international cooperation, and education programs.

  16. The right to life

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Stavri Sinjari

    2013-06-01

    Full Text Available The right to life constitutes one of the main human rights and freedoms, foreseen by article 21 of the Albanian Constitution and article 2 of European Human Rights Convention. No democratic or totalitarian society can function without guarantees and protection of the human right to life We intend to address these issues on our article: What is life. What we legally understand with life. When the life starts and finish. How this right has evolved. Which is the state interest on protecting the life. Should we consider that the life is the same for all. Should the state interfere at any cost to protect the life. Is there any criminal charge for responsible persons to the violation of this right. Is this issue treated by European Human Rights Court. What are the Albanian legal provisions on protection of this right. This research is performed mainly according to a comparative and analytical methodology. Comperative analysis will be present almost throughout the paper. Treatment of issues of this research will be achieved through a system comparable with international standards in particular and the most advanced legislation in this area. At the same time, this research is conducted by analytical and statistical data processing. We believe that our research will make a modest contribution, not only to the legal literature, but also to criminal policy makers, law makers, lawyers and attorneys.

  17. Go4Life

    Medline Plus

    Full Text Available ... Go4Life exercises to improve your strength! Stronger muscles can make it easier to do everyday things like ... 513 views Trainer Sandy shows Irene that you can do Go4Life exercises anywhere, even the kitchen! CC ...

  18. Go4Life

    Medline Plus

    Full Text Available ... Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight 360° ... more This item has been hidden Go4Life Exercises — Balance Play all Try some of these Go4Life exercises ...

  19. Go4Life

    Medline Plus

    Full Text Available ... years ago 17,529 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. ... Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's Toe Stand. ...

  20. Is Life Unique?

    Science.gov (United States)

    Abel, David L.

    2011-01-01

    Is life physicochemically unique? No. Is life unique? Yes. Life manifests innumerable formalisms that cannot be generated or explained by physicodynamics alone. Life pursues thousands of biofunctional goals, not the least of which is staying alive. Neither physicodynamics, nor evolution, pursue goals. Life is largely directed by linear digital programming and by the Prescriptive Information (PI) instantiated particularly into physicodynamically indeterminate nucleotide sequencing. Epigenomic controls only compound the sophistication of these formalisms. Life employs representationalism through the use of symbol systems. Life manifests autonomy, homeostasis far from equilibrium in the harshest of environments, positive and negative feedback mechanisms, prevention and correction of its own errors, and organization of its components into Sustained Functional Systems (SFS). Chance and necessity—heat agitation and the cause-and-effect determinism of nature’s orderliness—cannot spawn formalisms such as mathematics, language, symbol systems, coding, decoding, logic, organization (not to be confused with mere self-ordering), integration of circuits, computational success, and the pursuit of functionality. All of these characteristics of life are formal, not physical. PMID:25382119

  1. Go4Life

    Medline Plus

    Full Text Available ... Balance Play all Try some of these Go4Life exercises to improve your balance! Balance is important because it can help reduce your risk for falls. 3:01 Play next Play now Go4Life Exercise--Stand on One Foot - Duration: 3 minutes, 1 ...

  2. Alternative way of life

    International Nuclear Information System (INIS)

    Fischer, C.

    1980-01-01

    The volume describes the reasons why more and more people seek alternative ways of life, the theoretical background and what alternative life means in practice as well as the sociological significance and history of the alternative movement. It also contains statements of persons who have 'got out' and advice on energy-saving. (HSCH) [de

  3. Planets and Life

    Science.gov (United States)

    Sullivan, Woodruff T., III; Baross, John

    2007-09-01

    Foreword; Preface; Contributors; Prologue; Part I. History: 1. History of astrobiological ideas W. T. Sullivan and D. Carney; 2. From exobiology to astrobiology S. J. Dick; Part II. The Physical Stage: 3. Formation of Earth-like habitable planets D. E. Brownlee and M. Kress; 4. Planetary atmospheres and life D. Catling and J. F. Kasting; Part III. The Origin of Life on Earth: 5. Does 'life' have a definition? C.E. Cleland and C. F. Chyba; 6. Origin of life: crucial issues R. Shapiro; 7. Origin of proteins and nucleic acids A. Ricardo and S. A. Benner; 8. The roots of metabolism G.D. Cody and J. H. Scott; 9. Origin of cellular life D. W. Deamer; Part IV. Life on Earth: 10. Evolution: a defining feature of life J. A. Baross; 11. Evolution of metabolism and early microbial communities J. A. Leigh, D. A. Stahl and J. T. Staley; 12. The earliest records of life on Earth R. Buick; 13. The origin and diversification of eukaryotes M. L. Sogin, D. J. Patterson and A. McArthur; 14. Limits of carbon life on Earth and elsewhere J. A. Baross, J. Huber and M. Schrenk; 15. Life in ice J. W. Deming and H. Eicken; 16. The evolution and diversification of life S. Awramik and K. J. McNamara; 17. Mass extinctions P. D. Ward; Part V. Potentially Habitable Worlds: 18. Mars B. M. Jakosky, F. Westall and A. Brack; 19. Europa C. F. Chyba and C. B. Phillips; 20. Titan J. I. Lunine and B. Rizk; 21. Extrasolar planets P. Butler; Part VI. Searching for Extraterrestrial Life: 22. How to search for life on other worlds C. P. McKay; 23. Instruments and strategies for detecting extraterrestrial life P. G. Conrad; 24. Societial and ethical concerns M. S. Race; 25. Planetary protection J. D. Rummel; 26. Searching for extraterrestrial intelligence J. C. Tarter; 27. Alien biochemistries P. D. Ward and S. A. Benner; Part VII. Future of the Field: 28. Disciplinary and educational opportunities L. Wells, J. Armstrong and J. Huber; Epilogue C. F. Chyba; Appendixes: A. Units and usages; B. Planetary

  4. Life History Approach

    DEFF Research Database (Denmark)

    Olesen, Henning Salling

    2015-01-01

    as in everyday life. Life histories represent lived lives past, present and anticipated future. As such they are interpretations of individuals’ experiences of the way in which societal dynamics take place in the individual body and mind, either by the individual him/herself or by another biographer. The Life...... History approach was developing from interpreting autobiographical and later certain other forms of language interactive material as moments of life history, i.e. it is basically a hermeneutic approach. Talking about a psycho-societal approach indicates the ambition of attacking the dichotomy...... of the social and the psychic, both in the interpretation procedure and in some main theoretical understandings of language, body and mind. My article will present the reflections on the use of life history based methodology in learning and education research as a kind of learning story of research work....

  5. Disrupted Refugee Family Life

    DEFF Research Database (Denmark)

    Shapiro, Ditte Krogh

    2017-01-01

    Fleeing civil war involves managing life threatening events and multiple disruptions of everyday life. The theoretical potentials of analysing the recreation of everyday family life among Syrian refugees in Denmark is explored based on conceptualizations that emphasize the collective agency...... of family members in social historical contexts. Studying the multiple perspectives of family members shows how social support conceptualized as care practises is conflictual in the changing everyday family practices that are transformed by policy. The purpose of studying how families manage to flee civil...... war and struggle to recreate an everyday life in exile is to contribute with contextualization and expansion of mainstream understandings of family life, suffering, and resilience in refugee family trajectories in multiple contexts....

  6. Emergence of Life

    Directory of Open Access Journals (Sweden)

    Marie-Paule Bassez

    2011-09-01

    Full Text Available Indeed, even if we know that many individual components are necessary for life to exist, we do not yet know what makes life emerge. One goal of this journal Life is to juxtapose articles with multidisciplinary approaches and perhaps to answer in the near future this question of the emergence of life. Different subjects and themes will be developed, starting of course with the multiple definitions of life and continuing with others such as: life diversity and universality; characteristics of living systems; thermodynamics with energy and entropy; kinetics and catalysis; water in its different physical states; circulation of sap and blood and its origin; the first blood pump and first heart; the first exchange of nutrients between cells, sap and blood; essential molecules of living systems; chirality; molecular asymmetry and its origin; formation of enantiomer excess and amplification; microscopic observations on a micrometer and sub-micrometer scales, at molecular and atomic levels; the first molecules at the origin of genetic information, viroids, circular RNA; regions of space or the area inside membranes and cells capable of initiating and maintaining life; phenomena at the origin of the emergence of life; molecules studied in the traditional field of chemistry and in the recent field of nanoscience governed by new laws; interaction between the individual molecules and components of living systems; interaction between living systems and the environment; transfer of information through generations; continuation of life from one generation to the next; prebiotic chemistry and prebiotic signatures on Earth, on Mars, on other planets; biosignatures of the first forms of life; fossils and pseudofossils dating 3.5 Ga ago and more recent ones; experimental fossilization; pluricellular eukaryotes dating 2.1 Ga ago; sudden increase in oxygen in the atmosphere around 2.0 to 2.5 Ga ago and its relation to geology; shell symmetry; aging with

  7. Web of life and ways of life

    Directory of Open Access Journals (Sweden)

    Caterina Croce

    2013-03-01

    Full Text Available The notion of bios is a key-concept in Foucault's research. In the studies about the ancient world, bios stands out as an ethic substance relevant to the practice, the control and the transformation of the self. It is worth investigating the analogies and the differences between the notion of bios as it is meant in the last lectures at the Collège de France and that of bios as a creative force, shared and plural, that we find in previous seasons of Foucault research. The issue of 'way of life' allows us to explore the ambivalences of this topic. In its singular/plural declination, bios raises questions about the common living, which results from the coexistence and sharing of different ways of life – bioi – that cut through the ground of the institutionalized relationships.

  8. Between Gorleben life and city life

    International Nuclear Information System (INIS)

    Halbach, D.; Panzer, G.

    1980-01-01

    The authors lived for quite a long time in Wendland, the village of opponents of atomic energy at Gorleben. They regard the conflict on the issue of Gorleben and atomic energy as being located within the fundamental conflict existing between various ways of life: between the rather traditional region with the centralistic model of the atomic state and their hopes for decentralized ecological communities. They report on the practical development of this resistance and point out its forms of struggle which have to be proportionate to the atomic antagonist, friends and foes in the region as well as to their own requirements and objectives concerning an ecological and independent way of life. (HSCH) [de

  9. Life on Mars

    Science.gov (United States)

    McKay, Christopher P.; Cuzzi, Jeffrey (Technical Monitor)

    1996-01-01

    Although the Viking results may indicate that Mars has no life today, the possibility exists that Mars may hold the best record of the events that led to the origin of life. There is direct geomorphological evidence that in the past Mars had large amounts of liquid water on its surface. Atmospheric models would suggest that this early period of hydrological activity was due to the presence of a thick atmosphere and the resulting warmer temperatures. From a biological perspective the existence of liquid water, by itself motivates the question of the origin of life on Mars. From studies of the Earth's earliest biosphere we know that by 3.5 Gyr. ago, life had originated on Earth and reached a fair degree of biological sophistication. Surface activity and erosion on Earth make it difficult to trace the history of life before the 3.5 Gyr timeframe. If Mars did maintain a clement environment for longer than it took for life to originate on Earth, then the question of the origin of life on Mars follows naturally.

  10. Major stressful life events and other risk factors for first admission with mania

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Agerbo, Esben; Mortensen, Preben Bo

    2004-01-01

    OBJECTIVES: To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age. METHODS: Case register study with linkage of the Danish Psychiatric Central Research ...... disorder. The susceptibility to major life stressors of inducing mania does not seem to change throughout life....

  11. Life Writing After Empire

    DEFF Research Database (Denmark)

    A watershed moment of the twentieth century, the end of empire saw upheavals to global power structures and national identities. However, decolonisation profoundly affected individual subjectivities too. Life Writing After Empire examines how people around the globe have made sense of the post...... in order to understand how individual life writing reflects broader societal changes. From far-flung corners of the former British Empire, people have turned to life writing to manage painful or nostalgic memories, as well as to think about the past and future of the nation anew through the personal...

  12. NNP Life Management Programmes

    International Nuclear Information System (INIS)

    Hervia Ruperez, F.

    1996-01-01

    Around the world, power station owners are increasingly concerned to optimise Plant Life Management. In response, they are setting up Life Management programmes, of more or less ambitious scope and depth. Strategic, economic and security concerns and the close link between life extension work and the improved maintenance practices that are so important today, will increase and global these programmes for monitoring and conservation or mitigation of ageing. These programmes are all based on knowledge of the precise condition of all components and population with the greatest effect on the economics and safety of the plant, and trends in changes in their condition. (Author)

  13. Conducting everyday life

    DEFF Research Database (Denmark)

    Juhl, Pernille

    , they are involved in preventive interventions. I conducted participatory observations with the children in their everyday life. Overall, the study stresses that even small children must be perceived as active participants who act upon and struggle with different conditions and meaning making processes across......In the paper I discuss how small children (0-4 year) develop through ‘conducting everyday life’ across contexts (Holzkamp 2013). I discuss how this process of conducting everyday life is essential when discussing the ‘good life for children’ from a child perspective. These issues are addressed...... contexts (home, day care, part-time foster family) and in relation to other co-participants....

  14. Life Cycle Sustainability Dashboard

    DEFF Research Database (Denmark)

    Traverso, Marzia; Finkbeiner, Matthias; Jørgensen, Andreas

    2012-01-01

    One method to assess the sustainability performance of products is life cycle sustainability assessment (LCSA), which assesses product performance considering the environmental,economic, and social dimensions of the life cycle. The results of LCSA can be used to compare different products...... of sustainability is the communicability of the results by means of a graphical representation (a cartogram), characterized by a suitable chromatic scale and ranking score. The integration of LCSA and the dashboard of sustainability into a so-called Life Cycle Sustainability Dashboard (LCSD) is described here...

  15. Virkeligheder i Second Life

    DEFF Research Database (Denmark)

    Jensen, Sisse Siggaard

    "Virkeligheder i Second Life" er en beretning, der bygger på tre case studier samt omfattende observationer i den virtuelle verden Second Life i perioden 2006 til 2008. Beretningen er den ene af to bøger der bygger på forskning i virtuelle verdener; de tre case studier er: Wonderful Denmark, en...... virtuel virksomhed, Literary, et virtuelt bibliotek, Times, en afdeling af en real life virksomhed. Den anden bog: "Oplevelser i en virtuel verden" omhandler den virtuelle verden EverQuest - et masserollespil....

  16. Life extension economic analysis

    International Nuclear Information System (INIS)

    Smithling, A.P.

    1992-01-01

    Life extension economic analyses of fossil fueled power plants need the development of consistent methods which consider the capital costs associated with component replacement or repair and estimates of normal station capital expenditures over the units remaining life. In order to link capital and production costs, Niagra Mohawk Power Corp. develops most and worst cases. A most case includes capital components that would definitely need replacement or modification for life extension. The worst case scenario contains must case capital costs plus various components which may need replacement or modification. In addition, two forecasted conditions are used, base case capacity and low capacity

  17. BWR internals life assurance

    International Nuclear Information System (INIS)

    Herrera, M.L.; Stancavage, P.P.

    1988-01-01

    Boiling water reactor (BWR) internal components play an important role in power plant life extension. Many important internals were not designed for easy removal and changes in material properties and local environmental effects due to high radiation makes stress corrosion cracking more likely and more difficult to correct. Over the past several years, operating experience has shown that inspection, monitoring and refurbishment can be accomplished for internal structures with existing technology. In addition, mitigation techniques which address the causes of degradation are available to assure that life extension targets can be met. This paper describes the many considerations and aspects when evaluating life extension for reactor vessel internals

  18. Noise and Quality of Life

    Directory of Open Access Journals (Sweden)

    Michael D. Seidman

    2010-10-01

    Full Text Available Noise is defined as an unwanted sound or a combination of sounds that has adverse effects on health. These effects can manifest in the form of physiologic damage or psychological harm through a variety of mechanisms. Chronic noise exposure can cause permanent threshold shifts and loss of hearing in specific frequency ranges. Noise induced hearing loss (NIHL is thought to be one of the major causes of preventable hearing loss. Approximately 10 million adults and 5.2 million children in the US are already suffering from irreversible noise induced hearing impairment and thirty million more are exposed to dangerous levels of noise each day. The mechanisms of NIHL have yet to be fully identified, but many studies have enhanced our understanding of this process. The role of oxidative stress in NIHL has been extensively studied. There is compelling data to suggest that this damage may be mitigated through the implementation of several strategies including anti-oxidant, anti-ICAM 1 Ab, and anti JNK intervention. The psychological effects of noise are usually not well characterized and often ignored. However, their effect can be equally devastating and may include hypertension, tachycardia, increased cortisol release and increased physiologic stress. Collectively, these effects can have severe adverse consequences on daily living and globally on economic production. This article will review the physiologic and psychologic consequences of noise and its effect on quality of life.

  19. Meaning in life and intuition.

    Science.gov (United States)

    Heintzelman, Samantha J; King, Laura A

    2016-03-01

    Three correlational studies and 2 experiments examined the association between meaning in life (MIL) and reliance on intuitive information processing. In Studies 1-3 (total N = 5,079), Faith in Intuition (FI) scale and MIL were correlated positively, controlling for religiosity, positive mood, self-esteem, basic need satisfaction, and need for cognition. Two experiments manipulated processing style. In Study 4 (N = 614), participants were randomly assigned to complete the Cognitive Reflection Task (CRT; Fredrick, 2005) either immediately before (reflective/low intuitive mindset condition) or immediately after (control condition) rating MIL. Condition did not affect MIL. However, low MIL rated before the CRT predicted superior performance and greater time spent on the task. The association between reflection and MIL was curvilinear, such that MIL was strongly negatively related to CRT performance particularly at low levels of MIL. In Study 5 (N = 804), intuitive or reflective mindsets were induced and FI and MIL were measured. Induced processing style study did not affect MIL. However, those high in MIL were more responsive to the intuitive mindset induction. The relationship between FI and MIL was curvilinear (in this and the correlational studies), with intuitive processing being strongly positively related to MIL particularly at higher levels of MIL. Although often considered in the context of conscious reflection, MIL shares a positive relationship with reliance on gut feelings, and high MIL may facilitate reliance on those feelings. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  20. Go4Life

    Medline Plus

    Full Text Available ... is important because it can help reduce your risk for falls. 3:01 Play next Play now Go4Life Exercise--Stand on One Foot - Duration: 3 minutes, 1 second. National Institute ...

  1. End of Life Care

    Science.gov (United States)

    ... Related Topics Choosing Wisely Join our e-newsletter! Aging & Health A to Z End of Life Care ... be used. Ice chips, popsicles, moist swabs, or artificial saliva can help prevent the mouth from becoming ...

  2. The stress of life

    National Research Council Canada - National Science Library

    Selye, H

    1978-01-01

    .... This is also a dependable personal guide that tells you how to combat both physical and mental stress, how to handle yourself during the stress of everyday life, and how your bodily changes can help...

  3. Life-history interviews

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    2010-01-01

    in qualitative interviews. I first presented the paper on a conference on life history research at Karlstad University in November 2010. My main purpose was to establish whether a paper discussing the use of time line interviews should be placed in the context of a life history research. The valuable comments......My first encounter with life history research was during my Ph.D. research. This concerned a multi-method study of nomadic mobility in Senegal. One method stood out as yielding the most interesting and in-depth data: life story interviews using a time line. I made interviews with the head...... of the nomadic households and during these I came to understand the use of mobility in a complex context of continuity and change, identity and belonging in the Fulani community. Time line interviews became one of my favourite tool in the years to follow, a tool used both for my research in various settings...

  4. Aquatic Life Criterion - Selenium

    Science.gov (United States)

    Documents pertaining to the 2016 Acute and Chronic Ambient Aquatic Life Water Quality Criteria for Selenium (Freshwater). These documents include what the safe levels of Selenium are in water for the majority of species.

  5. Life after stoma creation

    DEFF Research Database (Denmark)

    Danielsen, Anne Kjærgaard

    2013-01-01

    , as well as an alteration in the bodily design. Research in the field may provide additional information about central elements when adapting to life with a stoma. There are currently no studies that adequately focus on the relationship between health-related quality of life and stoma construction...... in a Danish context, neither for temporary or permanent construction, nor in relation to the importance of stoma handling. Purpose: The overall objective of the study was to investigate health-related quality of life related to stoma creation and patient education. Methodologically, the project......: Impact on everyday life and Educational Needs. The study included 15 participants who were interviewed in groups related to whether they were treated for cancer or non-cancer. The results showed that participants often experienced the stoma as a taboo, and emotions related to stigma were identified...

  6. Early life vaccination

    DEFF Research Database (Denmark)

    Nazerai, Loulieta; Bassi, Maria Rosaria; Uddbäck, Ida Elin Maria

    2016-01-01

    Intracellular pathogens represent a serious threat during early life. Importantly, even though the immune system of newborns may be characterized as developmentally immature, with a propensity to develop Th2 immunity, significant CD8+ T-cell responses may still be elicited in the context of optimal...... the first period of life and provide a pertinent alternative in infant vaccinology. To address this, infant mice were vaccinated with three different adenoviral vectors and the CD8+ T-cell response after early life vaccination was explored. We assessed the frequency, polyfunctionality and in vivo...... cytotoxicity of the elicited memory CD8+ T cells, as well as the potential of these cells to respond to secondary infections and confer protection. We further tested the impact of maternal immunity against our replication-deficient adenoviral vector during early life vaccination. Overall, our results indicate...

  7. Life History Patterns

    DEFF Research Database (Denmark)

    Jones, Owen

    2016-01-01

    of these patterns and highlights the need to consider senescence from a broad taxonomic scope to truly understand the evolution of aging. Keywords: Aging; Demography; Evolution; Fertility; Gompertz; Life span; Mortality; Ontogenescence; Reproduction; Reproductive senescence; Senescence; Survivorship...

  8. Go4Life

    Medline Plus

    Full Text Available ... strength! Stronger muscles can make it easier to do everyday things like get up from a chair, ... 797 views Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's ...

  9. Is life supernatural?

    Science.gov (United States)

    Levin, Gilbert V.

    2015-09-01

    The big question of the origin of life is examined. The paradox created by Pasteur's resounding edict: Life only comes from life, pitted against the need for spontaneous generation is explored. This seemingly dead-end conundrum contrasts sharply with the great progress we have made in understanding the evolution of the species since Darwin's revolutionary insight. The conditions and sources of energy that might have promoted non-living molecules and compounds to cross the sharp line from inert to living are contemplated. Abiotic synthesis might help explain the origin, but still fails to explain the moment of vitalization. A different approach to discovering when the inert becomes alive is proposed. The need for, and a way to bring forth, a "Bio-Einstein" to solve this penultimate question of life's origin are presented.

  10. Aquatic Life Criteria - Ammonia

    Science.gov (United States)

    Documents related to EPA's final 2013 Aquatic Life Ambient Water Quality Criteria for Ammonia (Freshwater). These documents pertain to the safe levels of Ammonia in water that should protect to the majority of species.

  11. [Limiting life sustaining therapies].

    Science.gov (United States)

    Azoulay, E

    2006-09-01

    Intensivists are increasingly implementing end-of-life decisions in patients who remain dependent on life sustaining therapies without hope for recovery. Descriptive studies have provided epidemiological data on ICU end-of-life care, identifying areas for improvement. Qualitative studies have highlighted the complexity of the decision making process. In addition to considering the legal and ethical issues involved, this review describes cultural, religious and individual variations observed in ICU end-of-life care. It is important for intensivists to respect patients' preferences and values, but also, in some family members, to avoid increasing the burden and the guilt of sharing the decision. Intensivists should improve their ability to meet the needs of dying patients and their family members. Each situation, patient, family and caregiver is unique, and therefore needs a specific approach. Introducing palliative care and multidisciplinary teams into the ICU might provide an additional opportunity for patients and families to be informed and listened to.

  12. Life not death

    DEFF Research Database (Denmark)

    Milner, George R.; Boldsen, Jesper L.

    2017-01-01

    Analytically sophisticated paleoepidemiology is a relatively new development in the characterization of past life experiences. It is based on sound paleopathological observations, accurate age-at-death estimates, an explicit engagement with the nature of mortality samples, and analytical procedures...

  13. Extending mine life

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Mine layouts, new machines and techniques, research into problem areas of ground control and so on, are highlighted in this report on extending mine life. The main resources taken into account are coal mining, uranium mining, molybdenum and gold mining

  14. Early Life Stages

    Science.gov (United States)

    Childhood should be viewed as a sequence of lifestages, from birth through infancy and adolescence. When assessing early life risks, consideration is given to risks resulting from fetal exposure via the pregnant mother, as well as postnatal exposures.

  15. Aquatic Life Criteria - Copper

    Science.gov (United States)

    Documents pertain to Aquatic Life Ambient Water Quality criteria for Copper (2007 Freshwater, 2016 Estuarine/marine). These documents contain the safe levels of Copper in water that should protect to the majority of species.

  16. Go4Life

    Medline Plus

    Full Text Available ... Play next Play now How Alzheimer's Changes the Brain - Duration: 4 minutes. National Institute On Aging 36, ... views Trainer Sandy shows Leo how to improve his grip with this exercise from Go4Life. CC 2: ...

  17. Everyday Family Life

    DEFF Research Database (Denmark)

    Westerling, Allan

    2010-01-01

    and methods and it illustrates this by presenting a research design which comprises a multi-methodological approach combining quantitative and qualitative methods in the study of the relationship between the individual and the social (the individual/social), thus enabling analysis of both meaning...... project takes a social psychological approach, combining quantitative and qualitative methods in a longitudinal study of family life. The knowledge interest of the project is the constitution of communality and individuality in everyday family life. This article presents the theoretical framework......What are the implications of ongoing processes of modernization and individualization for social relations in everyday life? This overall research question is the pivotal point in empirical studies at the Centre of Childhood-, Youth- and Family Life Research at Roskilde University. One research...

  18. Go4Life

    Medline Plus

    Full Text Available ... 17,679 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. CC 1: ... 19 Play next Play now Choosing Nutrient Dense Foods - Duration: 6 minutes, 19 seconds. National Institute On ...

  19. Life: Complexity and Diversity

    Indian Academy of Sciences (India)

    tinual increase in the diversity of life over evolutionary time. Ways of ... Centre for Ecological. Scienc'es .... plants evolved flowers to attract pollinators and reward them with .... with the evolving complexity of their interactions in communi- ties.

  20. Aquatic Life Benchmarks

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Aquatic Life Benchmarks is an EPA-developed set of criteria for freshwater species. These benchmarks are based on toxicity values reviewed by EPA and used in the...

  1. Nuclear plant life extension

    International Nuclear Information System (INIS)

    Negin, C.A.

    1989-01-01

    The nuclear power industry's addressing of life extension is a natural trend in the maturation of this technology after 20 years of commercial operation. With increasing emphasis on how plants are operated, and less on how to build them, attention is turning on to maximizing the use of these substantial investments. The first studies of life extension were conducted in the period from 1978 and 1982. These were motivated by the initiation, by the Nuclear Regulatory Commission (NRC), of studies to support decommissioning rulemaking. The basic conclusions of those early studies that life extension is feasible and worth pursuing have not been changed by the much more extensive investigations that have since been conducted. From an engineering perspective, life extension for nuclear plants is fundamentally the same as for fossil plants

  2. Earliest life on earth

    CERN Document Server

    Golding, Suzanne D

    2010-01-01

    This volume integrates the latest findings on earliest life forms, identified and characterized in some of the oldest rocks on Earth. It places emphasis on the integration of analytical methods with observational techniques and experimental simulations.

  3. Life expectancy and education

    DEFF Research Database (Denmark)

    Hansen, Casper Worm; Strulik, Holger

    2017-01-01

    , we find that US states with higher mortality rates from cardiovascular disease prior to the 1970s experienced greater increases in adult life expectancy and higher education enrollment. Our estimates suggest that a one-standard deviation higher treatment intensity is associated with an increase...... in adult life expectancy of 0.37 years and 0.07–0.15 more years of higher education....

  4. NPP life management (abstracts)

    International Nuclear Information System (INIS)

    Litvinskij, L.L.; Barbashev, S.V.

    2002-01-01

    Abstracts of the papers presented at the International conference of the Ukrainian Nuclear Society 'NPP Life Management'. The following problems are considered: modernization of the NPP; NPP life management; waste and spent nuclear fuel management; decommissioning issues; control systems (including radiation and ecological control systems); information and control systems; legal and regulatory framework. State nuclear regulatory control; PR in nuclear power; training of personnel; economics of nuclear power engineering

  5. Life between buildings

    DEFF Research Database (Denmark)

    Gehl, Jan

    2001-01-01

    A classic is republished. Life between Buildings was first published in 1971. This book - frequently revised over the years - is still the best source for understanding how people use public spaces in our cities. Published in many languages, it is a standard textbook in Architecture and Planning...... Schools around the world, and continues to be the undisputed basic introduction to the interplay between public space design and social life. This book is now available in its third English language version....

  6. Technology makes life better

    Institute of Scientific and Technical Information of China (English)

    李红

    2015-01-01

    There are many theories about the relationship between technology and society.With the development of world economy,technology has made great progress.However,many changes were taken place in our daily life,especially the appearance of computer.Sending emails,chatting with others online,search for information which is what we need to learn and many other demands in people’s daily life,computers make all of it into possibility.

  7. NASA Life Sciences Program

    Science.gov (United States)

    1995-01-01

    This Life Science Program video examines the variety of projects that study both the physiological and psychological impacts on astronauts due to extended space missions. The hazards of space radiation and microgravity effects on the human body are described, along with these effects on plant growth, and the performance of medical procedures in space. One research technique, which is hoped to provide help for future space travel, is the study of aquanauts and their life habits underwater.

  8. Patient life in hospital

    DEFF Research Database (Denmark)

    Ludvigsen, Mette Spliid

    Patient life in hospital.A qualitative study of informal relationships between hospitalised patients Introduction Within a patientology framework, this PhD dissertation is about an empirical study on patient life that provides insight into the nature of informal relationships between patients...... are created through stories about three roughly framed aspects of hospitalisation: A. Being together with fellow patients entails a constant dilemma, B. Relationships between patients are restricted and extended and C. Shifting perspectives in solidarity. Conclusion Patients' hospitalisation is strongly...

  9. Life In The Universe!

    CERN Multimedia

    2001-01-01

    Is there life elsewhere in the Universe? Are we alone? These questions have always fascinated humanity and for more than 30 years, physicists, biologists, chemists, cosmologists and astronomers have worked tirelessly to answer these questions. Yet just this past week at CERN students from all over Europe came to present their ideas on the subject and listen to the latest on extraterrestrial life from some of the world's most prestigious researchers.

  10. Life extension and life cycle management

    International Nuclear Information System (INIS)

    Hoang, H.

    2010-10-01

    To continue the effort of nuclear energy as the clean energy offsetting the increase in greenhouse gas emission that contributes to the increased global warming effect, the nuclear industry is focused on the optimization of their current nuclear generation assets. Plant life extension (Plex) and Plant life management (Plim), together with power up rate, are the key strategies for the optimization effort. Plex begins with the process to obtain the regulatory approval for an additional 20 years of operation, beyond the current 40-year limit. This highly standardized process consists of the following steps: 1) Scoping: identify the systems, structures and components for inclusion in the license renewal scope of work. 2) Screening: narrow down the selection of the in-scope systems, structures and components based on passive and long-lived characteristics. 3) Aging management review: demonstrate that aging effects will continue to be managed during the additional 20 years of operation. 4) Time limiting aging analyses: confirm the acceptability of design bases analyses that assume the 40-year plant life as a key input assumptions. To provide a consistent approach for the preparation of the license renewal application, the following are the key guidance documents: NUREG-1800: Standard review plan; NUREG-1801: Generic aging lessons learned; Nuclear Energy Institute NEI 95-10. The objectives of Plim are to focus on improving plant reliability/availability, and to plan for equipment upgrades for efficiency improvement as well as technological obsolescence. Plim is a technical evaluation combined with a risk assessment to produce a long-range business plant with a time horizon of 10 years or longer. Due to its long view nature, this plan will be reviewed on a yearly basis for any required adjustments. The technical evaluation consists of the following major steps: 1) Select systems, structures and components with performance deficiencies experience. 2) Collect operating data

  11. Curcuma alismatifolia vase life

    Directory of Open Access Journals (Sweden)

    Bruno Trevenzoli Favero

    2017-04-01

    Full Text Available Cut curcuma stem has a reported vase life of 7 to 21 days and this difference in vase life is probably due to a combination of different factors such as growing conditions and postharvest treatments. However, the cut flower industry needs key postharvest information for new species and cultivars to be able to effectively market the flowers. The objectives of this study was to evaluate the effect of commercial hydrator and holding solutions, commercial growth regulator formulation, floral foam, ethylene and silver thiosulfate (STS on the postharvest handling of C. alismatifolia cultivars. Control treatment (deionized water had better vase life than the combinations of the commercial hydrator for 4h and commercial holding solution for 44h. Floral foam reduced vase life to 17 days from 23 days for the control treatment. The growth regulators gibberellin plus benzyladenine (GA4+7 + BA had a positive effect on the fresh weight keeping parameter, but further studies are necessary. STS did not improve vase life, nor did ethylene at 1 µL L-1 reduce it. The curcuma cultivars tested were not positively affected by vase solution composition and had an average vase life in deionized water of 21 days.

  12. Life Span Developmental Approach

    Directory of Open Access Journals (Sweden)

    Ali Eryilmaz

    2011-03-01

    Full Text Available The Life Span Developmental Approach examines development of individuals which occurs from birth to death. Life span developmental approach is a multi-disciplinary approach related with disciplines like psychology, psychiatry, sociology, anthropology and geriatrics that indicates the fact that development is not completed in adulthood, it continues during the life course. Development is a complex process that consists of dying and death. This approach carefully investigates the development of individuals with respect to developmental stages. This developmental approach suggests that scientific disciplines should not explain developmental facts only with age changes. Along with aging, cognitive, biological, and socioemotional development throughout life should also be considered to provide a reasonable and acceptable context, guideposts, and reasonable expectations for the person. There are three important subjects whom life span developmental approach deals with. These are nature vs nurture, continuity vs discontinuity, and change vs stability. Researchers using life span developmental approach gather and produce knowledge on these three most important domains of individual development with their unique scientific methodology.

  13. [Pregnancy-induced haemolytic anaemia].

    Science.gov (United States)

    Karagiozova, J; Masseva, A; Ivanov, St; Marinov, B; Kulinska, R; Boiadjiev, D; Jordanova, D

    2014-01-01

    This is the clinical case of a primiparous eight month pregnant female, presenting with symptoms of pregnancy-induced acute haemolytic anaemia (haemolytic aneamia provoked by an immune mechanism, intra- and extra-erythrocyte defects, and HELLP syndrome were excluded). The anaemia progressed to become life-threatening for both the pregnant women and the foetus, which brought the following questions into consideration: diagnosis of anaemia during pregnancy; dosing of corticosteroid therapy; possibility of giving birth to a viable foetus and prognosis for next pregnancies. Owing to the inter-disciplinary efforts, the life and health of this pregnant woman were preserved, but the foetus was lost.

  14. Sex and life expectancy.

    Science.gov (United States)

    Seifarth, Joshua E; McGowan, Cheri L; Milne, Kevin J

    2012-12-01

    A sexual dimorphism in human life expectancy has existed in almost every country for as long as records have been kept. Although human life expectancy has increased each year, females still live longer, on average, than males. Undoubtedly, the reasons for the sex gap in life expectancy are multifaceted, and it has been discussed from both sociological and biological perspectives. However, even if biological factors make up only a small percentage of the determinants of the sex difference in this phenomenon, parity in average life expectancy should not be anticipated. The aim of this review is to highlight biological mechanisms that may underlie the sexual dimorphism in life expectancy. Using PubMed, ISI Web of Knowledge, and Google Scholar, as well as cited and citing reference histories of articles through August 2012, English-language articles were identified, read, and synthesized into categories that could account for biological sex differences in human life expectancy. The examination of biological mechanisms accounting for the female-based advantage in human life expectancy has been an active area of inquiry; however, it is still difficult to prove the relative importance of any 1 factor. Nonetheless, biological differences between the sexes do exist and include differences in genetic and physiological factors such as progressive skewing of X chromosome inactivation, telomere attrition, mitochondrial inheritance, hormonal and cellular responses to stress, immune function, and metabolic substrate handling among others. These factors may account for at least a part of the female advantage in human life expectancy. Despite noted gaps in sex equality, higher body fat percentages and lower physical activity levels globally at all ages, a sex-based gap in life expectancy exists in nearly every country for which data exist. There are several biological mechanisms that may contribute to explaining why females live longer than men on average, but the complexity of the

  15. Life sciences recruitment objectives

    Science.gov (United States)

    Keefe, J. Richard

    1992-01-01

    The goals of the Life Sciences Division of the Office of Space Sciences and Application are to ensure the health, well being and productivity of humans in space and to acquire fundamental scientific knowledge in space life sciences. With these goals in mind Space Station Freedom represents substantial opportunities and significant challenges to the Life Sciences Division. For the first time it will be possible to replicate experimental data from a variety of simultaneously exposed species with appropriate controls and real-time analytical capabilities over extended periods of time. At the same time, a system for monitoring and ameliorating the physiological adaptations that occur in humans subjected to extended space flight must be evolved to provide the continuing operational support to the SSF crew. To meet its goals, and take advantage of the opportunities and overcome the challenges presented by Space Station Freedom, the Life Sciences Division is developing a suite of discipline-focused sequence. The research phase of the Life Sciences Space Station Freedom Program will commence with the utilization flights following the deployment of the U.S. laboratory module and achievement of Man Tended Capability. Investigators that want the Life Sciences Division to sponsor their experiment on SSF can do so in one of three ways: submitting a proposal in response to a NASA Research Announcement (NRA), submitting a proposal in response to an Announcement of Opportunity (AO), or submitting an unsolicited proposal. The scientific merit of all proposals will be evaluated by peer review panels. Proposals will also be evaluated based on relevance to NASA's missions and on the results of an Engineering and Cost Analyses. The Life Sciences Division expects that the majority of its funding opportunities will be announced through NRA's. It is anticipated that the first NRA will be released approximately three years before first element launch (currently scheduled for late 1995

  16. Quality of Life in Europe

    Directory of Open Access Journals (Sweden)

    Norina Popovici

    2016-01-01

    Many times we wondered why people want a certain comfort in exchange for sacrifices on longterm: we want houses, cars, holidays, quality services. All our life we work and give up many tothings (maybe more important than achieving material benefits. It's about quality of life. In thispaper we analyzed the quality of life in Europe addressing several factors, such as subjective wellbeing,living standards and material constraints, work-life balance, family life and social life,health and education.

  17. Maintenance for life management

    International Nuclear Information System (INIS)

    Hevia, F.

    1997-01-01

    Life Management is based on the detection, monitoring and control of long-term degradation that affects individual plant components and important populations. Experience has shown that in many cases current maintenance practices do not attend to ageing directly; instead they deal with the consequences when it is already too late, when good Life Management is no longer practical. This has brought about the need for specific Maintenance Evaluation and Improvement Programmes to adjust to the basic objective of Life Management which is to project against, monitor and mitigate ageing that can affect the safe and profitable operating life of the facility. New regulatory requirements for ageing monitoring and effective maintenance to ensure safety (Maintenance Rule) have made it even more necessary to implement the Maintenance Evaluation Programme to cope with ageing, and to integrate that tasks in both programmes to optimise effort and use of tools. This paper presents a brief description of the objectives and methodologies of these Programmes which has been applied to plants around the world and in Spain at the Garona and Vandellos II plants in Spain as part of the PIE project for developing a Remanent Life Evaluation System for nuclear power plants. (Author)

  18. Work–Life Interventions

    Directory of Open Access Journals (Sweden)

    He Lu Calvin Ong

    2014-07-01

    Full Text Available Despite disparities in the conceptualization of work–life balance (WLB and work–life harmony (WLH in the literature, there remains no evidence till date to validate these differences. Furthermore, there are currently no insights that shed light on the relationship between work–life initiatives and key business strategies of contemporary organizations. Hence, the current study investigated the differences between the constructs of WLB and WLH using a cognitive dissonance approach and assessed the impact of work–life interventions, based on these approaches, on individual creativity at work. Hundred participants, age ranging from 18 to 32 years (M = 23.94, SD = 3.87, with at least 6 months of working experience were recruited. Using an online questionnaire, participants were randomly assigned into WLB (n = 55 or WLH (n = 45 conditions. Participants were tasked to complete pre- and post-intervention measures of individual creativity, as well as a manipulation check using a cognitive dissonance scale. Results showed that participants in the WLB condition elicit higher levels of cognitive dissonance compared with participants in the WLH condition. This indicates an implicit difference in the constructs of WLB and harmony. Second, findings also suggest that work–life interventions adopting a WLH approach will have a more positive impact on individuals’ creativity at work compared with interventions targeted at achieving balance. Research, practical, and cultural implications of the findings are discussed in the article.

  19. Steam generator life management

    International Nuclear Information System (INIS)

    King, P.; McGillivray, R.; Reinhardt, W.; Millman, J.; King, B.; Schneider, W.

    2003-01-01

    'Full-Text:' Steam Generator Life Management responsibility embodies doing whatever is necessary to maintain the steam generation equipment of a nuclear plant in effective, reliable service. All comes together in that most critical deliverable, namely the submission of the documentation which wins approval for return to service after an outage program. Life management must address all aspects of SG reliability over the life of the plant. Nevertheless, the life management activities leading up to return to service approval is where all of it converges. Steam Generator Life Management activities entail four types of work, all equally important in supporting the objective of successful operation. These activities are i) engineering functions; including identification of inspection and maintenance requirements, outage planning and scope definition plus engineering assessment, design and analysis as necessary to support equipment operation, ii) fitness of service work; including the expert evaluation of degradation mechanisms, disposition of defects for return to service or not, and the fitness for service analysis as required to justify ongoing operation with acceptable defects, iii) inspection work; including large scale eddy current inspection of tubing, the definition of defect size and character, code inspections of pressure vessel integrity and visual inspections for integrity and iv) maintenance work; including repairs, retrofits, cleaning and modifications, all as necessary to implement the measures defined during activities i) through iii). The paper discusses the approach and execution of the program for the achievement of the above objectives and particularly of items i) and ii). (author)

  20. Experimentally increasing sedentary behavior results in decreased life satisfaction

    OpenAIRE

    Edwards, Meghan K.; Loprinzi, Paul D.

    2017-01-01

    Background: No study has experimentally manipulated sedentary behavior and evaluated its effect on life satisfaction. Thus, the purpose of this study was to evaluate the effects of a free-living, sedentary behavior-inducing randomized controlled intervention on life satisfaction. Methods: Active, young adults between the ages of 18-35 were recruited and randomly assigned into a sedentary behavior intervention group (n = 26) or a control group (n = 13). The intervention group par...

  1. Life quality index revisited

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager

    2004-01-01

    The derivation of the life quality index (LQI) is revisited for a revision. This revision takes into account the unpaid but necessary work time needed to stay alive in clean and healthy conditions to be fit for effective wealth producing work and to enjoyable free time. Dimension analysis...... at birth should not vary between countries. Finally the distributional assumptions are relaxed as compared to the assumptions made in an earlier work by the author. These assumptions concern the calculation of the life expectancy change due to the removal of an accident source. Moreover a simple public...... consistency problems with the standard power function expression of the LQI are pointed out. It is emphasized that the combination coefficient in the convex differential combination between the relative differential of the gross domestic product per capita and the relative differential of the expected life...

  2. Life Out of Chaos

    Science.gov (United States)

    Arrhenius, Gustaf

    2002-01-01

    Doctinary overlays on the definition of life can effectively be avoided by focusing discussion on microorganisms, their vital processes, and their genetic pedigree. To reach beyond these present and highly advanced forms of life and to inquire about its origin it is necessary to consider the requirements imposed by the environment. These requirements include geophysically and geochemically acceptable conjectures for the generation of source compounds, their concentration from dilute solution, and their selective combination into functional biomolecules. For vital function these macromolecules require programming in the form of specific sequence motifs. This critical programming constitutes the scientifically least understood process in the origin of life. Once this stage has been surpassed the laws of Darwinian evolution can operate in ways that are understood and experimentally demonstrated.

  3. The origami of life

    Energy Technology Data Exchange (ETDEWEB)

    Lezon, Timothy R [Department of Physics, 104 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States); Banavar, Jayanth R [Department of Physics, 104 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States); Maritan, Amos [Dipartimento di Fisica ' G Galilei' and INFN, Universita di Padova, Via Marzolo 8, 35131 Padova (Italy)

    2006-01-25

    All living organisms rely upon networks of molecular interactions to carry out their vital processes. In order for a molecular system to display the properties of life, its constituent molecules must themselves be endowed with several features: stability, specificity, self-organization, functionality, sensitivity, robustness, diversity and adaptability. We argue that these are the emergent properties of a unique phase of matter, and we demonstrate that proteins, the functional molecules of terrestrial life, are perfectly suited to this phase. We explore, through an understanding of this phase of matter, the physical principles that govern the operation of living matter. Our work has implications for the design of functionally useful nanoscale devices and the ultimate development of physically based artificial life.

  4. The origami of life

    International Nuclear Information System (INIS)

    Lezon, Timothy R; Banavar, Jayanth R; Maritan, Amos

    2006-01-01

    All living organisms rely upon networks of molecular interactions to carry out their vital processes. In order for a molecular system to display the properties of life, its constituent molecules must themselves be endowed with several features: stability, specificity, self-organization, functionality, sensitivity, robustness, diversity and adaptability. We argue that these are the emergent properties of a unique phase of matter, and we demonstrate that proteins, the functional molecules of terrestrial life, are perfectly suited to this phase. We explore, through an understanding of this phase of matter, the physical principles that govern the operation of living matter. Our work has implications for the design of functionally useful nanoscale devices and the ultimate development of physically based artificial life

  5. Plant life management

    International Nuclear Information System (INIS)

    Charbonneau, S.; Framatome, J.B.

    1992-01-01

    Plant life assessment and extension studies have been performed by numerous companies all over the world. Critical equipment has been identified as well as various degradation mechanisms involved in the plant aging process. Nowadays one has to think what to implement to improve the existing situation in the Nuclear Power Plant (NPP). FRAMATOME has undertaken this thought process in order to find the right answers and bring them to utilities facing either critical concern for plant life extension or the problem of management of power plant potential longevity. This is why we prepared a Plant Life Improvement Action Plan, comprising 10 (ten) major items described hereafter using examples of work performed by FRAMATOME for its utility customers desiring to manage the lives of their plants, both in France with EDF and abroad

  6. Life with osteoporosis

    DEFF Research Database (Denmark)

    Hansen, Carrinna

    Background: Osteoporosis is considered a major worldwide public health problem. Men and women with osteoporosis are mostly unaware of the illness, until bone fractures occur. It is estimated that more than one in three European women and one in five men over 50 years will experience osteoporotic...... fractures followed by considerable morbidity and mortality. In line with many other chronic illnesses, one of the pronounced challenges related to osteoporosis is considered to be compliance and persistence to medical treatment. The causes of low compliance and persistence to treatment remain unclear....... Living with a chronic illness often affects the entire human life situation, specifically, emotionally and existentially. How this is experienced personally and how this affects the individual’s life is still unknown. Aim: To gain a deeper understanding of patients’ life with osteoporosis by determining...

  7. Strategies of Life Detection

    CERN Document Server

    Botta, Oliver; Gomez-Elvira, Javier; Javaux, Emmanuelle; Selsis, Franck; Summons, Roger

    2008-01-01

    The search for life outside the Earth has been one of mankind's most challenging quests. We have reached a level of technology that allows for initial steps toward thorough scientific investigation. The aim of this workshop was to take an interdisciplinary look at the signatures that would be indicative of past or present life on another planet and compare them to biosignatures on Earth. The purpose of the workshop was also to discuss state-of-the-art in-situ instruments that are envisioned to search for these signatures in the exploration of the solar system, as well as the discussion of concepts descriptive of the search for habitable planets around other stars. This book is intended to provide a reference to scientists and instrument developers working in the field of in-situ and remote life detection. It can also be used as an interdisciplinary introduction for students and post-doctoral researchers entering this new and exciting field.

  8. Negotiating Life Chances

    DEFF Research Database (Denmark)

    Korzenevica, Marina

    to and negotiate both educational and labour mobility - both of which are associated with the chance of a better life. This thesis is about young people (aged 16-31): How they negotiate their life chances and how they contribute to transformations of the socio-political space of their communities in two villages...... becoming. Aspirations prevail over political interests: young people navigate and negotiate their engagement in party and community politics by making calculations concerning their own mobility, life strategies and obligations to kin. In this way, young men engage in, but also balance and shift......, conversely, can only aspire to educational mobility due to gender norms. Furthermore, many of their hopes of ‘becoming somebody’ collapse upon marriage. Women find that they cannot continue their education, nor use the skills they have acquired in local politics, as they need to follow traditional...

  9. Life In The Universe!

    CERN Multimedia

    2001-01-01

    An alien invasion of CERN? Is there life elsewhere in the Universe? Are we alone? These questions have always fascinated humanity and for more than 30 years, physicists, biologists, chemists, cosmologists and astronomers have worked tirelessly to answer these questions. Yet just this past week at CERN students from all over Europe came to present their ideas on the subject and listen to the latest on extraterrestrial life from some of the world's most prestigious researchers. Students participating in the programme were encouraged to present their views on extraterrestrial life creatively and boy did they! The team from Portugal ran performances of Greek Theatre, the team from Hungary created a board game, while the team from Belgium recited poetry questioning the existence of extraterrestrials. But all was not light hearted, there were touching presentations of violin and piano by the French team and a very thought provoking theatre performance by the German team contrasting the search for extraterrestrial...

  10. Practical Life: The Keystone of Life, Culture, and Community

    Science.gov (United States)

    Ramani, Uma

    2013-01-01

    Uma Ramani's characterization of practical life is philosophical and anthropological, suggesting that "human history is the story of the evolution of our practical life activities." Practical life is a collaborative activity that creates community and culture. One's adaptation to life through the daily work of ordering our environment…

  11. Balancing Life Roles to Achieve Career Happiness and Life Satisfaction.

    Science.gov (United States)

    Peronne, Kristin Marie

    2000-01-01

    A study guided by Super's Life Span, Life Space approach included a survey of 119 women and 66 men about sacrifices made in life and work roles to achieve balance and satisfaction. Differences in sacrifices and satisfaction were related to the combination of life roles they occupied. (SK)

  12. COMPETENCYTHE FORMATION FOR LIFE

    Directory of Open Access Journals (Sweden)

    Milagros Mederos-Piñeiro

    2016-07-01

    Full Text Available The formation of life competences is the result of a quality education that prepares students to meet the challenges of a fast moving world where equality and equal opportunities should constitute premises of education; training them is a challenge teachers to assume new generations contribute actively to a better world. In Cuba are important research on the formation of communication competences and self-regulated learning in primary school. The paper shows the result of an investigation that provides a methodology for the formation of life competences in primary school education, used as an essential pathway research activity. The methodological approach of research has a quantitative approach and an explanatory scope to establish and make sense of understanding the causal relationship between the direction of research activity and training of life competences. Theoretical, empirical and mathematical-statistical, for characterizing the initial state, processing of results and analysis: research methods are used. The application of the methodology for the formation of life competences makes teachers lead the teaching-learning process with a research and transforming teaching concept, where the school is the protagonist of their learning and causes changes in their performances, which are evident in the formed competences related to effective and affective communication; the solution of problems related to life; the use of means in obtaining the knowledge and the expression of a behavior consistent with school and social demands. The effectiveness of the methodology confirms that there is a causal relationship between the direction of research activity by teachers and the formation of life competences in school.

  13. Autonomy: Life and Being

    Science.gov (United States)

    Williams, Mary-Anne

    This paper uses robot experience to explore key concepts of autonomy, life and being. Unfortunately, there are no widely accepted definitions of autonomy, life or being. Using a new cognitive agent architecture we argue that autonomy is a key ingredient for both life and being, and set about exploring autonomy as a concept and a capability. Some schools of thought regard autonomy as the key characteristic that distinguishes a system from an agent; agents are systems with autonomy, but rarely is a definition of autonomy provided. Living entities are autonomous systems, and autonomy is vital to life. Intelligence presupposes autonomy too; what would it mean for a system to be intelligent but not exhibit any form of genuine autonomy. Our philosophical, scientific and legal understanding of autonomy and its implications is immature and as a result progress towards designing, building, managing, exploiting and regulating autonomous systems is retarded. In response we put forward a framework for exploring autonomy as a concept and capability based on a new cognitive architecture. Using this architecture tools and benchmarks can be developed to analyze and study autonomy in its own right as a means to further our understanding of autonomous systems, life and being. This endeavor would lead to important practical benefits for autonomous systems design and help determine the legal status of autonomous systems. It is only with a new enabling understanding of autonomy that the dream of Artificial Intelligence and Artificial Life can be realized. We argue that designing systems with genuine autonomy capabilities can be achieved by focusing on agent experiences of being rather than attempting to encode human experiences as symbolic knowledge and know-how in the artificial agents we build.

  14. Women in public life.

    Science.gov (United States)

    1992-01-01

    The UN Division for the Advancement of Women publication has devoted an issue to the role of women in public lie based on an analysis of women's status in industrialized countries presented in Vienna, Austria, in May 1991. Women already contribute to political life and make a difference in politics, but societal institutions and government processes have not yet adapted to this fact. Women's nongovernmental organizations promote women's interests at the governmental level, but often do not have the economic or political power as do other interests groups such as trade unions. Women often participation public life via their membership in women's organizations, community action groups, voluntary organizations, and other close to home groups. They prefer to participate in activities which are problem solving rather than institution building. These activities and groups operate outside established political institutions and are not considered as part of public and political life. Society's exclusion of women from leadership positions in public life keeps it from benefiting from the special contributions that women bring to decision making. Women show a tendency to have different leadership styles than men (e.g., ability to relate to people affected by their decisions), which are most needed for the modern world. They often do not campaign just for women's issues, but, once in office, they do tend to become more involved in women's issues. Women have affected positive changes in career and child care, often on a non-Socialist agenda, in various countries (e.g. Norway). This effect is referred to as the politics of motherhood. More access to politics and public life calls for removal of structural and situational barriers including the glass ceiling, discrimination, insufficient funds, and bearing most of the responsibility for child care. The UN women's groups has drafted a platform for interregional consultation on women's role in public life and scheduled the 4th

  15. Resistance in Everyday Life

    DEFF Research Database (Denmark)

    This book is about resistance in everyday life, illustrated through empirical contexts from different parts of the world. Resistance is a widespread phenomenon in biological, social and psychological domains of human cultural development. Yet, it is not well articulated in the academic literature....... The contributors deal with strategies for handling dissent by individuals or groups, specifically dissent through resistance. Resistance can be a location of intense personal, interpersonal and cultural negotiation, and that is the primary reason for interest in this phenomenon. Ordinary life events contain...

  16. Meaning in Work Life

    DEFF Research Database (Denmark)

    Ravn, Ib

    meaningful is still lacking (Harpaz & Fu, 2002), as are definitions of key terms. Here, I define meaning as the experience that something fits into a wider context or coheres within a larger whole.     I conceptualize meaning in work life as deriving from four factors, each of which helps us contribute...... to something larger than ourselves (Seligman, 2002) through our work. Thus, a person experiences meaning in work life when she... A. is able to use her signature strengths at work (Peterson and Seligman, 2004), B. makes an important contribution to the workplace (Drucker, 1999), C. participates in a productive...

  17. Spacelab Life Sciences-1

    Science.gov (United States)

    Dalton, Bonnie P.; Jahns, Gary; Meylor, John; Hawes, Nikki; Fast, Tom N.; Zarow, Greg

    1995-01-01

    This report provides an historical overview of the Spacelab Life Sciences-1 (SLS-1) mission along with the resultant biomaintenance data and investigators' findings. Only the nonhuman elements, developed by Ames Research Center (ARC) researchers, are addressed herein. The STS-40 flight of SLS-1, in June 1991, was the first spacelab flown after 'return to orbit', it was also the first spacelab mission specifically designated as a Life Sciences Spacelab. The experiments performed provided baseline data for both hardware and rodents used in succeeding missions.

  18. Life Cycle Environmental Management

    DEFF Research Database (Denmark)

    Pedersen, Claus Stig; Jørgensen, Jørgen; Pedersen, Morten Als

    1996-01-01

    A precondition for environmentally conscious management is the awareness of the environmental impact potentials created by an industrial company. There is an obvious need for management tools to support the implementation of relevant environmental criteria into the industrial decision making...... processes. The discipline of life cycle environmental management (LCEM) focuses on the incorporation of environmental criteria from the life cycles of products and other company activities into the company management processes. This paper introduces the concept of LCEM as an important element...... of the complete set of environmental objects in an industrial manufacturing company....

  19. Earth before life.

    Science.gov (United States)

    Marzban, Caren; Viswanathan, Raju; Yurtsever, Ulvi

    2014-01-09

    A recent study argued, based on data on functional genome size of major phyla, that there is evidence life may have originated significantly prior to the formation of the Earth. Here a more refined regression analysis is performed in which 1) measurement error is systematically taken into account, and 2) interval estimates (e.g., confidence or prediction intervals) are produced. It is shown that such models for which the interval estimate for the time origin of the genome includes the age of the Earth are consistent with observed data. The appearance of life after the formation of the Earth is consistent with the data set under examination.

  20. Life-threatening lithium-induced diabetes insipidus after colonic ...

    African Journals Online (AJOL)

    ... concentration of 185mmol/l and required ventilation after a respiratory arrest. We suggest any surgical patient who describes a history of bipolar disorder or lithium therapy should be questioned directly to ascertain confirmatory features of LINDI, and have post-operative polyuria treated with aggressive fluid replacement.

  1. Life in the Universe

    Science.gov (United States)

    2001-10-01

    Live Webcast from Europe's Leading Research Organisations Summary Is there life elsewhere in the Universe? Are we alone? These questions have always fascinated humanity and for more than 50 years, physicists, biologists, chemists, cosmologists, astronomers and other scientists have worked tirelessly to answer these fundamental questions. And now this November via webcast, all the world will have the opportunity to see and hear the latest news on extraterrestrial life from the most prestigious research centers and how for the past three months, European students have had the chance to jump into the scientists' shoes and explore these questions for themselves. The event is being sponsored by the European Organisation for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , in cooperation with the European Molecular Biology Laboratory (EMBL) and the European Synchrotron Radiation Facility (ESRF) and the European Association for Astronomy Education (EAAE). "Life in the Universe" is being mounted in collaboration with the Research Directorate-General of the European Commission for the European Week of Science and Technology in November 2001 . "Life in the Universe" competitions are already underway in 23 European countries to find the best projects from school students between 14 and 18. Two winning teams from each country will be invited to a final event at CERN in Geneva on 8-11 November 2001 to present their projects and discuss them with a panel of International Experts at a special three-day event. They will also compete for the "Super Prize" - a free visit to ESA's and ESO's research and technology facilities at Kourou and Paranal in South America. Students participating in the programme are encouraged to present their views on extraterrestrial life creatively. The only requirement is that the views be based upon scientific evidence. Many projects are being submitted just now - among them are scientific essays

  2. Corticosterone and pace of life in two life-history ecotypes of the garter snake Thamnophis elegans.

    Science.gov (United States)

    Palacios, Maria G; Sparkman, Amanda M; Bronikowski, Anne M

    2012-02-01

    Glucocorticoids are main candidates for mediating life-history trade-offs by regulating the balance between current reproduction and survival. It has been proposed that slow-living organisms should show higher stress-induced glucocorticoid levels that favor self-maintenance rather than current reproduction when compared to fast-living organisms. We tested this hypothesis in replicate populations of two ecotypes of the garter snake (Thamnophis elegans) that exhibit slow and fast pace of life strategies. We subjected free-ranging snakes to a capture-restraint protocol and compared the stress-induced corticosterone levels between slow- and fast-living snakes. We also used a five-year dataset to assess whether baseline corticosterone levels followed the same pattern as stress-induced levels in relation to pace of life. In accordance with the hypothesis, slow-living snakes showed higher stress-induced corticosterone levels than fast-living snakes. Baseline corticosterone levels showed a similar pattern with ecotype, although differences depended on the year of study. Overall, however, levels of glucocorticoids are higher in slow-living than fast-living snakes, which should favor self-maintenance and survival at the expense of current reproduction. The results of the present study are the first to relate glucocorticoid levels and pace of life in a reptilian system and contribute to our understanding of the physiological mechanisms involved in life-history evolution. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Second Life, Revisited

    Science.gov (United States)

    Bugeja, Michael J.

    2008-01-01

    An article this author wrote about avatar harassment and assault in Second Life (SL) inspired a considerable response after it was published. Perhaps the most notable reply was from Linden Lab, the company that created the virtual-reality world. In his initial essay ("The Chronicle of Higher Education," September 14, 2007; "The Education Digest,"…

  4. Emotions in Everyday Life.

    Science.gov (United States)

    Trampe, Debra; Quoidbach, Jordi; Taquet, Maxime

    2015-01-01

    Despite decades of research establishing the causes and consequences of emotions in the laboratory, we know surprisingly little about emotions in everyday life. We developed a smartphone application that monitored real-time emotions of an exceptionally large (N = 11,000+) and heterogeneous participants sample. People's everyday life seems profoundly emotional: participants experienced at least one emotion 90% of the time. The most frequent emotion was joy, followed by love and anxiety. People experienced positive emotions 2.5 times more often than negative emotions, but also experienced positive and negative emotions simultaneously relatively frequently. We also characterized the interconnections between people's emotions using network analysis. This novel approach to emotion research suggests that specific emotions can fall into the following categories 1) connector emotions (e.g., joy), which stimulate same valence emotions while inhibiting opposite valence emotions, 2) provincial emotions (e.g., gratitude), which stimulate same valence emotions only, or 3) distal emotions (e.g., embarrassment), which have little interaction with other emotions and are typically experienced in isolation. Providing both basic foundations and novel tools to the study of emotions in everyday life, these findings demonstrate that emotions are ubiquitous to life and can exist together and distinctly, which has important implications for both emotional interventions and theory.

  5. Go4Life

    Medline Plus

    Full Text Available ... YouTube Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight ... Go4Life exercises to improve your balance! Balance is important because it can help reduce your risk for ...

  6. Life and death.

    Science.gov (United States)

    Lloyd, J W

    1983-03-01

    In contrast with the other lectures given in the course on humanics and bioethics at the UOEH, which address the questions of life and death from the standpoint of the physician or the philosopher, this lecture considers these issues as seen by the cancer patient who has had a close encounter with death. The attitudes of Americans concerning abortion, the use of life-support systems, "mercy killings", suicide and the use of cancer chemotherapy are discussed with particular emphasis on restraints imposed by the courts, the churches and the family systems. An attempt is made to contrast the American and Japanese attitudes on these questions but this is difficult because of different cultural and religious backgrounds. The author describes his own experiences as a cancer patient who has approached death very closely and the changes in his own attitude toward life which results from the encounter with death. He also talks about the joy of being alive and describes his own experience with receiving cancer chemotherapy, the resulting discomfort and inconveniences and his feelings about a "tolerable" existence. Finally, the author considers the question of the "quality of life" for the cancer patient who has a violent reaction to certain forms of chemotherapy. This is a dilemma for the patient and the doctor who must consider the choice between death and a miserable existence.

  7. Learning for Life

    Science.gov (United States)

    Robotham, Dan

    2011-01-01

    People working in the field of education know well the positive effects adult and community learning can have on mental health and wellbeing. Participating in adult and community learning can help to widen social networks and improve life and employment chances; it makes for better general health; and can strengthen the learner's self-confidence,…

  8. Go4Life

    Medline Plus

    Full Text Available ... Alzheimer’s Disease Research Summit 2015 - Duration: 4 minutes, 36 seconds. National Institute On Aging 2,520 views ... now Go4Life Exercise--Back Stretch - Duration: 2 minutes, 36 seconds. National Institute On Aging 8,789 views ...

  9. Go4Life

    Medline Plus

    Full Text Available ... National Institute On Aging 6,876 views 6 years ago CC This item has been hidden Go4Life Exercises — Building Strength ... National Institute On Aging 29,945 views 6 years ago CC This item has been hidden Popular Uploads Play all ...

  10. Life Cycle Inventory Analysis

    DEFF Research Database (Denmark)

    Bjørn, Anders; Moltesen, Andreas; Laurent, Alexis

    2018-01-01

    of different sources. The output is a compiled inventory of elementary flows that is used as basis of the subsequent life cycle impact assessment phase. This chapter teaches how to carry out this task through six steps: (1) identifying processes for the LCI model of the product system; (2) planning...

  11. Go4Life

    Medline Plus

    Full Text Available ... YouTube Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight ... 17,362 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. CC 1: ...

  12. Go4Life

    Medline Plus

    Full Text Available ... YouTube Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight ... all Try some of these Go4Life exercises to improve your flexibility! 2:48 Play next Play now ...

  13. Go4Life

    Medline Plus

    Full Text Available ... National Institute On Aging 6,899 views 6 years ago CC This item has been hidden Go4Life Exercises — Building Strength ... National Institute On Aging 30,060 views 6 years ago CC This item has been hidden Popular Uploads Play all ...

  14. Investigating Teachers' Life Satisfaction

    Science.gov (United States)

    Dagli, Abidin; Baysal, Nigah

    2017-01-01

    The aim of this study is to determine the life satisfaction perceptions of teachers working at public primary schools according to some variables. In this study, descriptive survey model was used. A random sample of 200 teachers from 25 public primary schools in Diyarbakir/Turkey during 2013-2014 academic year were selected to represent the…

  15. Emotions in Everyday Life

    Science.gov (United States)

    2015-01-01

    Despite decades of research establishing the causes and consequences of emotions in the laboratory, we know surprisingly little about emotions in everyday life. We developed a smartphone application that monitored real-time emotions of an exceptionally large (N = 11,000+) and heterogeneous participants sample. People’s everyday life seems profoundly emotional: participants experienced at least one emotion 90% of the time. The most frequent emotion was joy, followed by love and anxiety. People experienced positive emotions 2.5 times more often than negative emotions, but also experienced positive and negative emotions simultaneously relatively frequently. We also characterized the interconnections between people’s emotions using network analysis. This novel approach to emotion research suggests that specific emotions can fall into the following categories 1) connector emotions (e.g., joy), which stimulate same valence emotions while inhibiting opposite valence emotions, 2) provincial emotions (e.g., gratitude), which stimulate same valence emotions only, or 3) distal emotions (e.g., embarrassment), which have little interaction with other emotions and are typically experienced in isolation. Providing both basic foundations and novel tools to the study of emotions in everyday life, these findings demonstrate that emotions are ubiquitous to life and can exist together and distinctly, which has important implications for both emotional interventions and theory. PMID:26698124

  16. Life Cycle Collection Management

    Directory of Open Access Journals (Sweden)

    Helen Shenton

    2003-09-01

    Full Text Available Life cycle collection management is a way of taking a long-term approach to the responsible stewardship of the British Library's collections and is one of the Library's strategic strands. It defines the different stages in a collection item's existence over time. These stages range from selection and acquisitions processing, cataloguing and press marking, through to preventive conservation, storage and retrieval. Life cycle collection management seeks to identify the costs of each stage in order to show the economic interdependencies between the phases over time. It thereby aims to demonstrate the long-term consequences of what the library takes into its collections, by making explicit the financial and other implications of decisions made at the beginning of the life cycle for the next 100 plus years. This paper describes the work over the past year at the British Library on this complex and complicated subject. It presents the emerging findings and suggests how it can be used for practical reasons (by individual curators and selectors and for economic, governance and political purposes. The paper describes the next steps in the project, for example, on a predictive data model. The British Library is seeking to benchmark itself against comparable organisations in this area. It intends to work with others on specific comparison for example, of life cycle costing of electronic and paper journals, as a prelude to eliding digital and 'traditional' formats.

  17. The secret of life

    Science.gov (United States)

    Jenkins, David; Kirsebom, Oliver

    2013-02-01

    Life as we know it would not be possible were it not for a particular nuclear energy level of carbon-12 predicted 60 years ago by Fred Hoyle. But the true nature of this energy level remains one of the biggest unsolved questions in nuclear physics, say David Jenkins and Oliver Kirsebom.

  18. Life's end: Ethnographic perspectives.

    Science.gov (United States)

    Goodwin-Hawkins, Bryonny; Dawson, Andrew

    2018-01-01

    In this introduction to the special issue, Life's End: Ethnographic Perspectives, we review the field of anthropological studies of death and dying. We make the argument that, largely because of its sub-disciplining into the larger field of the anthropology of religion, ritual and symbolism, the focus of anthropological research on death has been predominantly on post- rather than pre-death events, on death's beginnings rather than life's ends. Additionally, we argue that an anthropological aversion to the study of dying may also lie in the intimacy of the discipline's principal method, ethnography. Contrastingly, we argue that this very methodological intimacy can be a source of insight, and we offer this as a rationale for the special issue as a whole, which comprises eight ethnographic studies of dying and social relations at life's end from across Africa, Australia, Europe, and North America. Each of these studies is then summarized, and a rationale for their presentation around the themes of "structures of dying," "care for the dying," "hope in dying," and "ending life" is presented.

  19. Ethics for life scientists

    NARCIS (Netherlands)

    Korthals, M.J.J.A.A.; Bogers, R.J.

    2004-01-01

    In this book we begin with two contributions on the ethical issues of working in organizations. A fruitful side effect of this start is that it gives a good insight into business ethics, a branch of applied ethics that until now is far ahead of ethics for life scientists. In the second part, ethics

  20. Symposium: Student Life

    Science.gov (United States)

    Academic Questions, 2010

    2010-01-01

    To get an inside view of campus life today, the Intercollegiate Studies Institute (whose purpose is to foster in college students an appreciation of the values that sustain a free society) was approached and asked to supply a list of their Collegiate Network editors--students who are active on their campuses, interested in the issues facing higher…

  1. Emotions in Everyday Life.

    Directory of Open Access Journals (Sweden)

    Debra Trampe

    Full Text Available Despite decades of research establishing the causes and consequences of emotions in the laboratory, we know surprisingly little about emotions in everyday life. We developed a smartphone application that monitored real-time emotions of an exceptionally large (N = 11,000+ and heterogeneous participants sample. People's everyday life seems profoundly emotional: participants experienced at least one emotion 90% of the time. The most frequent emotion was joy, followed by love and anxiety. People experienced positive emotions 2.5 times more often than negative emotions, but also experienced positive and negative emotions simultaneously relatively frequently. We also characterized the interconnections between people's emotions using network analysis. This novel approach to emotion research suggests that specific emotions can fall into the following categories 1 connector emotions (e.g., joy, which stimulate same valence emotions while inhibiting opposite valence emotions, 2 provincial emotions (e.g., gratitude, which stimulate same valence emotions only, or 3 distal emotions (e.g., embarrassment, which have little interaction with other emotions and are typically experienced in isolation. Providing both basic foundations and novel tools to the study of emotions in everyday life, these findings demonstrate that emotions are ubiquitous to life and can exist together and distinctly, which has important implications for both emotional interventions and theory.

  2. Advanced Cardiac Life Support.

    Science.gov (United States)

    Kirkwood Community Coll., Cedar Rapids, IA.

    This document contains materials for an advanced college course in cardiac life support developed for the State of Iowa. The course syllabus lists the course title, hours, number, description, prerequisites, learning activities, instructional units, required text, six references, evaluation criteria, course objectives by units, course…

  3. Mosquito Life Cycle

    Science.gov (United States)

    Knowing the stages of the mosquito's life will help you prevent mosquitoes around your home and help you choose the right pesticides for your needs, if you decide to use them. All mosquito species go through four distinct stages during their live cycle.

  4. Ionizing radiation and life.

    Science.gov (United States)

    Dartnell, Lewis R

    2011-01-01

    Ionizing radiation is a ubiquitous feature of the Cosmos, from exogenous cosmic rays (CR) to the intrinsic mineral radioactivity of a habitable world, and its influences on the emergence and persistence of life are wide-ranging and profound. Much attention has already been focused on the deleterious effects of ionizing radiation on organisms and the complex molecules of life, but ionizing radiation also performs many crucial functions in the generation of habitable planetary environments and the origins of life. This review surveys the role of CR and mineral radioactivity in star formation, generation of biogenic elements, and the synthesis of organic molecules and driving of prebiotic chemistry. Another major theme is the multiple layers of shielding of planetary surfaces from the flux of cosmic radiation and the various effects on a biosphere of violent but rare astrophysical events such as supernovae and gamma-ray bursts. The influences of CR can also be duplicitous, such as limiting the survival of surface life on Mars while potentially supporting a subsurface biosphere in the ocean of Europa. This review highlights the common thread that ionizing radiation forms between the disparate component disciplines of astrobiology. © Mary Ann Liebert, Inc.

  5. Life Complexity and Diversity

    Indian Academy of Sciences (India)

    engineer life capable of surviving in outer space, and thereby trigger off ... sions; either a hit by an enormous asteroid or a major volcanic eruption. Madhav ... these, so that the world is now populated by around 9000 species of birds and 4000 ...

  6. Moral Life and Education

    Science.gov (United States)

    Noddings, Nel

    2016-01-01

    Nel Noddings, Lee Jacks Professor of Education, Emerita, at Stanford University, agrees with Professors Lapsley and Woodbury that moral aims are central to education. She has argued that the main aim of education is to produce better people--better in "all aspects of a complete life: moral, physical, social, vocational, aesthetic,…

  7. Life Expectancy in 2040

    DEFF Research Database (Denmark)

    Canudas-Romo, Vladimir; DuGoff, Eva H; Wu, Albert W.

    2016-01-01

    We use expert clinical and public health opinion to estimate likely changes in the prevention and treatment of important disease conditions and how they will affect future life expectancy. Focus groups were held including clinical and public health faculty with expertise in the six leading causes...

  8. Where life begins

    Energy Technology Data Exchange (ETDEWEB)

    Wickramasinghe, C [University Coll. of South Wales and Monmouthshire, Cardiff (UK)

    1977-04-21

    Recent laboratory studies of meteorites which, when combined with astronomical data on interstellar dust and prestellar molecular clouds, point to the evolution of a primitive biological system in interstellar space, are discussed. It is suggested that meteorites, which carried such systems, could have brought life to our planet.

  9. Where life begins

    International Nuclear Information System (INIS)

    Wickramasinghe, C.

    1977-01-01

    Recent laboratory studies of meteorites which, when combined with astronomical data on interstellar dust and prestellar molecular clouds, point to the evolution of a primitive biological system in interstellar space, are discussed. It is suggested that meteorites, which carried such systems, could have brought life to our planet. (U.K.)

  10. Life: Complexity and Diversity

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 4. Life : Complexity and Diversity Growing Larger. Madhav Gadgil. Series Article Volume 1 Issue 4 April 1996 pp 15-22. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/001/04/0015-0022 ...

  11. How life shaped Earth.

    Science.gov (United States)

    Gross, Michael

    2015-10-05

    Earth is much more complex than all the other solar system objects that we know. Thanks to its rich and diverse geology, our planet can offer habitats to a wide range of living species. Emerging insights suggest that this is not just a happy coincidence, but that life itself has in many ways helped to shape the planet.

  12. Go4Life

    Medline Plus

    Full Text Available ... Duration: 117 seconds. National Institute On Aging 6 years ago 12,952 views Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's Toe Stand. CC ... Exercise--Overhead Arm Raise - Duration: 88 seconds. National Institute On Aging 6 years ago 9,529 views Trainer Sandy shows Carol ...

  13. Life and language

    DEFF Research Database (Denmark)

    Cowley, Stephen

    2018-01-01

    , he argues, arises from participating in the living. Knowing, and coming to know, use repression and selection that can only be captured by non-disciplinary views of meaning. As part how life and language unfold, humans owe a duty of care to all of the living world: hence, action is needed now....

  14. The soil life cycle

    NARCIS (Netherlands)

    Leeuwen, van J.P.

    2016-01-01

    Soil is one of the most important natural resource for life on Earth and provides important ecosystem services, such as food production, carbon sequestration, water regulation and contaminant attenuation. Soil quality, defined as the soil’s ability to provide these services, is drastically

  15. Life History and Identity

    Science.gov (United States)

    Tierney, William G.

    2013-01-01

    This article uses the life history method to chronicle the challenges of a low-income, first-generation student en route to college. The paper addresses three questions: how Manuel navigates college and related topics such as roommates, family, and money; how he creates social networks; and how he works with adults such as teachers and…

  16. Life Satisfaction in Old Age

    OpenAIRE

    BRDIČKOVÁ, Monika

    2009-01-01

    The paper describes life satisfaction in old age. The theoretical part defines negative and positive aspects of old age, and further describes cognitive and emotional changes. The main content of the theoretical part is focused on life satisfaction, purposfulness and self-conception of seniors. The practical part includes qualitative research, which survays life satisfaction of seniors, directed on four dimensions of human life: self-conception, purpose of life, family and social relations. T...

  17. The positive and negative consequences of stressors during early life.

    Science.gov (United States)

    Monaghan, Pat; Haussmann, Mark F

    2015-11-01

    We discuss the long-term effects of stress exposure in pre- and early postnal life. We present an evolutionary framework within which such effects can be viewed, and describe how the outcomes might vary with species life histories. We focus on stressors that induce increases in glucocorticoid hormones and discuss the advantages of an experimental approach. We describe a number of studies demonstrating how exposure to these hormones in early life can influence stress responsiveness and have substantial long-term, negative consequences for adult longevity. We also describe how early life exposure to mild levels of stressors can have beneficial effects on resilience to stress in later life, and discuss how the balance of costs and benefits is likely dependent on the nature of the adult environment. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. Life Sciences Accomplishments 1994

    Science.gov (United States)

    Burnell, Mary Lou (Editor)

    1993-01-01

    The NASA Life and Biomedical Sciences and Applications Division (LBSAD) serves the Nation's life sciences community by managing all aspects of U.S. space-related life sciences research and technology development. The activities of the Division are integral components of the Nation's overall biological sciences and biomedical research efforts. However, NASA's life sciences activities are unique, in that space flight affords the opportunity to study and characterize basic biological mechanisms in ways not possible on Earth. By utilizing access to space as a research tool, NASA advances fundamental knowledge of the way in which weightlessness, radiation, and other aspects of the space-flight environment interact with biological processes. This knowledge is applied to procedures and technologies that enable humans to live and work in and explore space and contributes to the health and well-being of people on Earth. The activities of the Division are guided by the following three goals: Goal 1) Use microgravity and other unique aspects of the space environment to enhance our understanding of fundamental biological processes. Goal 2) Develop the scientific and technological foundations for supporting exploration by enabling productive human presence in space for extended periods. Goal 3) Apply our unique mission personnel, facilities, and technology to improve education, the quality of life on Earth, and U.S. competitiveness. The Division pursues these goals with integrated ground and flight programs involving the participation of NASA field centers, industry, and universities, as well as interactions with other national agencies and NASA's international partners. The published work of Division-sponsored researchers is a record of completed research in pursuit of these goals. During 1993, the LBSAD instituted significant changes in its experiment solicitation and peer review processes. For the first time, a NASA Research Announcement (NRA) was released requesting

  19. Starship Life Support

    Science.gov (United States)

    Jones, Harry W.

    2009-01-01

    The design and mass cost of a starship and its life support system are investigated. The mission plan for a multi generational interstellar voyage to colonize a new planet is used to describe the starship design, including the crew habitat, accommodations, and life support. Only current technology is assumed. Highly reliable life support systems can be provided with reasonably small additional mass, suggesting that they can support long duration missions. Bioregenerative life support, growing crop plants that provide food, water, and oxygen, has been thought to need less mass than providing stored food for long duration missions. The large initial mass of hydroponics systems is paid for over time by saving the mass of stored food. However, the yearly logistics mass required to support a bioregenerative system exceeds the mass of food solids it produces, so that supplying stored dehydrated food always requires less mass than bioregenerative food production. A mixed system that grows about half the food and supplies the other half dehydrated has advantages that allow it to breakeven with stored dehydrated food in about 66 years. However, moderate increases in the hydroponics system mass to achieve high reliability, such as adding spares that double the system mass and replacing the initial system every 100 years, increase the mass cost of bioregenerative life support. In this case, the high reliability half food growing, half food supplying system does not breakeven for 389 years. An even higher reliability half and half system, with three times original system mass and replacing the system every 50 years, never breaks even. Growing food for starship life support requires more mass than providing dehydrated food, even for multigeneration voyages of hundreds of years. The benefits of growing some food may justify the added mass cost. Much more efficient recycling food production is wanted but may not be possible. A single multigenerational interstellar voyage to

  20. Radiation induced oral mucositis

    Directory of Open Access Journals (Sweden)

    P S Satheesh Kumar

    2009-01-01

    Full Text Available Patients receiving radiotherapy or chemotherapy will receive some degree of oral mucositis The incidence of oral mucositis was especially high in patients: (i With primary tumors in the oral cavity, oropharynx, or nasopharynx; (ii who also received concomitant chemotherapy; (iii who received a total dose over 5,000 cGy; and (iv who were treated with altered fractionation radiation schedules. Radiation-induced oral mucositis affects the quality of life of the patients and the family concerned. The present day management of oral mucositis is mostly palliative and or supportive care. The newer guidelines are suggesting Palifermin, which is the first active mucositis drug as well as Amifostine, for radiation protection and cryotherapy. The current management should focus more on palliative measures, such as pain management, nutritional support, and maintenance, of good oral hygiene

  1. Group life insurance

    CERN Multimedia

    2013-01-01

    The CERN Administration wishes to inform staff members and fellows having taken out optional life insurance under the group contract signed by CERN that the following changes to the rules and regulations entered into force on 1 January 2013:   The maximum age for an active member has been extended from 65 to 67 years. The beneficiary clause now allows insured persons to designate one or more persons of their choice to be their beneficiary(-ies), either at the time of taking out the insurance or at a later date, in which case the membership/modification form must be updated accordingly. Beneficiaries must be clearly identified (name, first name, date of birth, address).   The membership/modification form is available on the FP website: http://fp.web.cern.ch/helvetia-life-insurance For further information, please contact: Valentina Clavel (Tel. 73904) Peggy Pithioud (Tel. 72736)

  2. Work-life balance

    Energy Technology Data Exchange (ETDEWEB)

    Roche, Pat

    2011-03-15

    Gay Renouf has opted for a work/life balance; with a chemistry degree she joined the Saskatchewan Research Council out of graduate school in 1986. She first worked on understanding surfactants in emulsions and then dealt more with petroleum engineering issues like pipeline specifications. She is looking at waterfloods in heavy and medium gravity pools and has discovered factors helping to produce heavy oil waterfloods. But all Renouf's life is not devoted to her work: she has been working part-time, spending her free time being a parent, training for marathons and being a running coach. Renouf believes that her passion for running is consistent with her work as a scientist.

  3. Life and language

    DEFF Research Database (Denmark)

    Cowley, Stephen

    2018-01-01

    Through evolution, the living unites life, language and human experience. A ‘one system’ view thus attends to acts of meaning, knowing and ethics. Pursuing this domain, I offer general discussion based on Paul Cobley’s Cultural Implications of Biosemiotics (2016). Interpretation, he argues, peels...... back symbolic, indexical and iconic layers of living. While applauding the scope of his view, as a linguist, I baulk at identifying ‘knowing’ with symbolic reference and its objects. Given first-order language, I think, people use observations (by both others and self) to construct as persons. While......, he argues, arises from participating in the living. Knowing, and coming to know, use repression and selection that can only be captured by non-disciplinary views of meaning. As part how life and language unfold, humans owe a duty of care to all of the living world: hence, action is needed now....

  4. Partying as Everyday Life

    DEFF Research Database (Denmark)

    Demant, Jakob; Østergaard, Jeanette

    2007-01-01

    situates the event in everyday life. By drawing on Maffesoli's (1996) concept of ‘sociality' and Lincoln's (2005) concept of zoning the spatial and social logic of the house, partying is analysed using both qualitative and quantitative material. The analysis suggests that the consumption of alcohol (i.......e. collective intoxication) is one way the parents' dining room is transformed creatively into a space for teenage partying. Hence, the social logic of a party is to consume alcohol collectively as it symbolises commitment to both the party and to the specific group of friends. Finally, attention is drawn...... to reaffirm friendship and is therefore an integrated part of adolescents' everyday life.  ...

  5. Abortion: Defending Life

    Directory of Open Access Journals (Sweden)

    Myriam Aldana

    2008-05-01

    Full Text Available This essay will analyze some of the debates around abortion in the National Congress due to the Constitutional Amendment Bill – PEC25/95, by Deputy Severino Cavalcanti (PPB/PE, where the main issue was precisely life defense. The discursive blocks that present the debate in relation to pregnancy interruption, the religious principles or biological determinism on which those debates are based, and the ways in which such discourses are maintained will be identified. Distinct understandings of life, as a result of the points used in such discourses, which are aligned with the position of the Catholic Church and the Feminist Movement - the social actors of this debate- are also discussed here.

  6. Chemical evolution and life

    Directory of Open Access Journals (Sweden)

    Malaterre Christophe

    2015-01-01

    Full Text Available In research on the origins of life, the concept of “chemical evolution” aims at explaining the transition from non-living matter to living matter. There is however strong disagreement when it comes to defining this concept more precisely, and in particular with reference to a chemical form of Darwinian evolution: for some, chemical evolution is nothing but Darwinian evolution applied to chemical systems before life appeared; yet, for others, it is the type of evolution that happened before natural selection took place, the latter being the birthmark of living systems. In this contribution, I review the arguments defended by each side and show how both views presuppose a dichotomous definition of “life”.

  7. The Right to Life

    Directory of Open Access Journals (Sweden)

    Varvara Coman

    2012-05-01

    Full Text Available In the present study, we set ourselves to analyze a subject, which, due to its importance andextreme complexity, generated many discussions and controversies both at national and international level:the right to life. The great evolution of the contemporary society and the progress registered in various fieldsbrought into the attention of the states, international organizations, specialists in the field and public opinionthe pressing problem of interpreting the content and limits of the human fundamental rights and liberties. Weset ourselves to analyze the main international instruments regulating the right to life and to identify thesituations where determining the content of this fundamental right in necessary. Without the intent of acomplete work, we understand, throughout this study, to highline the great importance of the right to liferespecting for the entire humanity.

  8. [Sedation in the terminal phase of life].

    Science.gov (United States)

    Verhagen, E H; Eliel, M R; de Graeff, A; Teunissen, S C

    1999-12-25

    In 2 patients, a woman aged 38 years and a man aged 48 years, in the terminal phase of life due to metastasized+ malignancy, palliative care failed. They suffered seriously from pain, delirium, restlessness, nausea, and fear. Deep sedation was given to induce almost continuous sleep without the intention of causing death. After one and five quiet days respectively the patients died. Deep sedation is an option when palliative care fails to diminish serious suffering. Midazolam, given by continuous subcutaneous infusion is the drug of choice.

  9. The Life Span Dwelling

    OpenAIRE

    Hans-Peter Hebensperger-Hüther; Gabriele Franger-Huhle

    2014-01-01

    The paper presents the findings from a survey of 10 different experimental housing projects in Bavaria. In 2005 students of architecture and students of social work at the University of Applied Science in Coburg approached the topic of “Life Span Dwelling” using interdisciplinary research methods. The scope of the research ranges from urban planning concepts to common spaces in the different neighborhoods, documenting user satisfaction with the individual unit and feasibility of rooms offered...

  10. AHP 47: LIFE

    Directory of Open Access Journals (Sweden)

    Bla ma skyabs བླ་མ་སྐྱབས།

    2017-04-01

    Full Text Available I had a female yak when I was a young child and drank her milk, which helped me grow. She was like a mother. One day I got very sick and was put in the hospital. My family did not have enough money for my medical care so Father sold the female yak to pay for my treatment. That yak saved my life again. While I was in the hospital, an old relative came to visit. ...

  11. Earth before life

    OpenAIRE

    Marzban, Caren; Viswanathan, Raju; Yurtsever, Ulvi

    2014-01-01

    Background A recent study argued, based on data on functional genome size of major phyla, that there is evidence life may have originated significantly prior to the formation of the Earth. Results Here a more refined regression analysis is performed in which 1) measurement error is systematically taken into account, and 2) interval estimates (e.g., confidence or prediction intervals) are produced. It is shown that such models for which the interval estimate for the time origin of the genome i...

  12. Extended Life Coolant Testing

    Science.gov (United States)

    2016-06-06

    number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 06-06-2016 2. REPORT TYPE Interim Report 3. DATES COVERED ... Corrosion Testing of Traditional and Extended Life Coolants 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Hansen, Gregory A. T...providing vehicle specific coolants. Several laboratory corrosion tests were performed according to ASTM D1384 and D2570, but with a 2.5x extended time

  13. Astronomy in Second Life

    Directory of Open Access Journals (Sweden)

    Gauthier, A.

    2007-10-01

    Full Text Available Second Life (SL is a multi-user virtual environment that is not limited to adult social entertainment. SL is also a 3D playground for innovative instructors and education/outreach professionals in the sciences. Astronomy and space science have a presence in SL, but it could be so much more. This paper describes some of the current astronomy themed spaces in SL and briefly discusses future innovations.

  14. Finance/security/life.

    OpenAIRE

    Langley, P.

    2017-01-01

    What is the contemporary relation between finance and security? This essay encourages further research into the securitization of finance by developing the notion of ‘finance/security/life’. A focus on the intersections of finance/security/life will be shown to prompt a broadened range of critical, cross-disciplinary concerns with the various ways in which financial markets are positioned as vital to securing wealth, welfare and wellbeing.

  15. Life on the cusp

    CERN Document Server

    Wu, Weimin

    2016-01-01

    While the first 30 years of new China's scientific development was a self-reliant era marked by the detonations of the atomic bomb, the hydrogen bomb, and the launch of the first artificial satellite, the second 30 years after the reform and opening up was signified by the introduction of the Internet to China. Weimin Wu is a unique legendary figure whose career spanned both periods. He not only contributed to the bomb and satellite projects, but also sent out the email from China to Switzerland in 1986, which was listed as the first event in the history of China's Internet development. The Tiananmen Square Protest in 1989 changed his life's trajectory, leading him to eventually immigrate to the US. His personal emotional life is also remarkable. With his experiences immersed in both Eastern and Western cultures, Wu came to believe in the convergence theory of social development, which provides a refreshing perspective for the readers. The autobiography records the details of his legendary life stories, from ...

  16. Stamina in later life.

    Science.gov (United States)

    Colerick, E J

    1985-01-01

    Patterns of aging raise a number of important questions concerning the paths to successful adaptation. What gives some older individuals their staying power in the face of misfortune? What causes others to function less effectively when stressed, to resist change? Clearly, the margin of safety, the degree of elasticity and resilience varies across individuals in the later years. This study focuses on event histories and current behavior of 62 elderly men and women (Phase I) and reports by their confidants (N = 62; Phase II). A central proposition, that stamina in later life depends, in part, on the appraisal of previous events involving loss is investigated using a model that incorporates aspects of earlier life, cognitive appraisal and clinically judged dimensions of stamina in old age. Multivariate (particularly path analytic) techniques are used to test the links between variable foci. Results suggest that antecedents of stamina involve the interaction of social resources and cognitive orientations. Specifically, stamina in later life is contingent, for the most part, on a triumphant, positive outlook during periods of adversity. Elderly so oriented are also those with robust health histories and marked educational accomplishments. Conversely, persons who view situations involving loss as threatening, overwhelming and potentially defeating experience no such outcome; low levels of stamina mark their later years. Interestingly, quality childhood ties matter for stamina in old age only by increasing the likelihood of perceptions of a supportive environment during hard times. The findings corroborate the general pattern of research documenting the importance of cognitive orientations in adaptive processes.

  17. Group Life Insurance

    CERN Multimedia

    2013-01-01

    The CERN Administration would like to remind you that staff members and fellows have the possibility to take out a life insurance contract on favourable terms through a Group Life Insurance.   This insurance is provided by the company Helvetia and is available to you on a voluntary basis. The premium, which varies depending on the age and gender of the person insured, is calculated on the basis of the amount of the death benefit chosen by the staff member/fellow and can be purchased in slices of 10,000 CHF.    The contract normally ends at the retirement age (65/67 years) or when the staff member/fellow leaves the Organization. The premium is deducted monthly from the payroll.   Upon retirement, the staff member can opt to maintain his membership under certain conditions.   More information about Group Life Insurance can be found at: Regulations (in French) Table of premiums The Pension Fund Benefit Service &...

  18. How life began.

    Science.gov (United States)

    Cloud, P

    1986-11-01

    Study of the origin of life has become a legitimate scientific inquiry, with an international, multidisciplinary membership and a cogent body of data. Experiments involving plausible early Earth conditions and biogeochemical analyses of carbonaceous meteorites imply a variety of available starting molecules. Biogeological evidence indicates microbial beginnings about 3800 million years (3.8 aeons) ago. By then the known universe had been in existence for perhaps 15 aeons and galaxies abundant for ten. Conditions suitable for the origin of life may require a long prior cosmic evolution. The natural origin of life on the early Earth is now widely agreed upon but not the pathways. The beginnings of catalysis, replication and a functional cell remain moot. Much discussion has centered on the templating role that crystals such as clays and zeolites might have played in prebiotic evolution. Recent discovery of the catalytic and replicative functions of RNA recommend it as the key molecule in the transition from chemical to biological evolution. Copyright © 1986. Published by Elsevier Ltd.

  19. Child life services.

    Science.gov (United States)

    Wilson, Jerriann M

    2006-10-01

    Child life programs have become standard in most large pediatric centers and even on some smaller pediatric inpatient units to address the psychosocial concerns that accompany hospitalization and other health care experiences. The child life specialist focuses on the strengths and sense of well-being of children while promoting their optimal development and minimizing the adverse effects of children's experiences in health care or other potentially stressful settings. Using play and psychological preparation as primary tools, child life interventions facilitate coping and adjustment at times and under circumstances that might prove overwhelming otherwise. Play and age-appropriate communication may be used to (1) promote optimal development, (2) present information, (3) plan and rehearse useful coping strategies for medical events or procedures, (4) work through feelings about past or impending experiences, and (5) establish therapeutic relationships with children and parents to support family involvement in each child's care, with continuity across the care continuum. The benefits of this collaborative work with the family and health care team are not limited to the health care setting; it may also optimize reintegration into schools and the community.

  20. Informal science education: lifelong, life-wide, life-deep.

    Science.gov (United States)

    Sacco, Kalie; Falk, John H; Bell, James

    2014-11-01

    Informal Science Education: Lifelong, Life-Wide, Life-Deep Informal science education cultivates diverse opportunities for lifelong learning outside of formal K-16 classroom settings, from museums to online media, often with the help of practicing scientists.

  1. Energy and quality of life

    International Nuclear Information System (INIS)

    Pasten, Cesar; Santamarina, Juan Carlos

    2012-01-01

    Energy is required to sustain life. A human-centered analysis of the worldwide energy situation is conducted in terms of quality of life-related variables that are affected, but not directly determined, by energy consumption. Data since 1980 show a continuous global increase in both energy consumption and quality of life, and lower population growth in countries with higher quality of life. Based on these trends, we advance non-linear energy consumption predictions and identify various plausible scenarios to optimally steer future energy demands, in order to maximize quality of life. The scenarios consider the coupling between energy consumption rate per capita, quality of life, population growth, social inequality, and governments’ energy-for-life efficiency. The results show the energy cost of increasing quality of life in the developing world, energy savings that can be realized by limiting overconsumption without impacting quality of life, and the role of governments on increasing energy-for-life efficiency and reducing social inequality. - Highlights: ► Energy consumption is inherently coupled to quality of life and population growth. ► Limiting overconsumption can keep 2040 energy consumption at 2010 levels. ► Restricting population growth has a minor effect on future energy demand. ► Social inequality reduction increases quality of life with a minor energy use. ► Increasing energy-for-life efficiency can keep 2040 energy use at 2010 levels.

  2. Inducing autophagy

    DEFF Research Database (Denmark)

    Harder, Lea M; Bunkenborg, Jakob; Andersen, Jens S.

    2014-01-01

    catabolism, which has recently been found to induce autophagy in an MTOR independent way and support cancer cell survival. In this study, quantitative phosphoproteomics was applied to investigate the initial signaling events linking ammonia to the induction of autophagy. The MTOR inhibitor rapamycin was used...... as a reference treatment to emphasize the differences between an MTOR-dependent and -independent autophagy-induction. By this means 5901 phosphosites were identified of which 626 were treatment-specific regulated and 175 were coregulated. Investigation of the ammonia-specific regulated sites supported that MTOR...

  3. Spacelab Life Sciences Research Panel

    Science.gov (United States)

    Sulzman, Frank; Young, Laurence R.; Seddon, Rhea; Ross, Muriel; Baldwin, Kenneth; Frey, Mary Anne; Hughes, Rod

    2000-01-01

    This document describes some of the life sciences research that was conducted on Spacelab missions. Dr. Larry Young, Director of the National Space Biomedical Research Institute, provides an overview of the Life Sciences Spacelabs.

  4. Medicine's Life Inside the Body

    Science.gov (United States)

    ... All Articles | Inside Life Science Home Page A Medicine's Life Inside the Body By Alison Davis Posted ... field that studies how the body reacts to medicines and how medicines affect the body. Scientists funded ...

  5. Life, Death, and Second Chances

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Special Section Life, Death, and Second Chances Past Issues / Fall 2007 ... that she was beginning to fear for her life. Was there any hope at all? Dr. Richard ...

  6. "Control Your Diabetes. For Life."

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Diabetes "Control Your Diabetes. For Life." Past Issues / Fall 2009 Table of Contents For information about "Control Your Diabetes. For Life" campaign, visit www.YourDiabetesInfo. ...

  7. Bioinformatics: future of life sciences

    International Nuclear Information System (INIS)

    Arif, R.; Ghafoor, M.; Saleem, M.; Baig, S.J.; Hassan, S.W.

    2004-01-01

    The vital part of our life or the basic unit of life is the cell. The cellular biomolecules function in a conjugate manner and this system provide us with the necessary elements of life, and the sciences that deals with nature function of the cell and it's molecular components are defined as life sciences. Vital subjects involved in maintaining the identity and functioning of cells are genomics and proteomics. (author)

  8. Boiler-turbine life extension

    Energy Technology Data Exchange (ETDEWEB)

    Natzkov, S. [TOTEMA, Ltd., Sofia (Bulgaria); Nikolov, M. [CERB, Sofia (Bulgaria)

    1995-12-01

    The design life of the main power equipment-boilers and turbines is about 105 working hours. The possibilities for life extension are after normatively regulated control tests. The diagnostics and methodology for Boilers and Turbines Elements Remaining Life Assessment using up to date computer programs, destructive and nondestructive control of metal of key elements of units equipment, metal creep and low cycle fatigue calculations. As well as data for most common damages and some technical decisions for elements life extension are presented.

  9. PREMIUMS CALCULATION FOR LIFE INSURANCE

    Directory of Open Access Journals (Sweden)

    ANA PREDA

    2012-10-01

    Full Text Available The paper presents the techniques and the formulas used on international practice for establishing the premiums for a life policy. The formulas are generally based on a series of indicators named mortality indicators which mainly point out the insured survival probability, the death probability and life expectancy at certain age. I determined, using a case study, the unique net premium, the annual net premium for a survival insurance, whole life insurance and mixed life insurance.

  10. Steam generator life management

    International Nuclear Information System (INIS)

    Tapping, R.L.; Nickerson, J.; Spekkens, P.; Maruska, C.

    1998-01-01

    Steam generators are a critical component of a nuclear power reactor, and can contribute significantly to station unavailability, as has been amply demonstrated in Pressurized Water Reactors (PWRs). CANDU steam generators are not immune to steam generator degradation, and the variety of CANDU steam generator designs and tube materials has led to some unexpected challenges. However, aggressive remedial actions, and careful proactive maintenance activities, have led to a decrease in steam generator-related station unavailability of Canadian CANDUs. AECL and the CANDU utilities have defined programs that will enable existing or new steam generators to operate effectively for 40 years. Research and development work covers corrosion and mechanical degradation of tube bundles and internals, chemistry, thermal hydraulics, fouling, inspection and cleaning, as well as provision for specially tool development for specific problem solving. A major driving force is development of CANDU-specific fitness-for-service guidelines, including appropriate inspection and monitoring technology to measure steam generator condition. Longer-range work focuses on development of intelligent on-line monitoring for the feedwater system and steam generator. New designs have reduced risk of corrosion and fouling, are more easily inspected and cleaned, and are less susceptible to mechanical damage. The Canadian CANDU utilities have developed programs for remedial actions to combat degradation of performance (Gentilly-2, Point Lepreau, Bruce A/B, Pickering A/B), and have developed strategic plans to ensure that good future operation is ensured. This report shows how recent advances in cleaning technology are integrated into a life management strategy, discusses downcomer flow measurement as a means of monitoring steam generator condition, and describes recent advances in hideout return as a life management tool. The research and development program, as well as operating experience, has identified

  11. Managing rail service life

    Directory of Open Access Journals (Sweden)

    Z. Popović

    2014-10-01

    Full Text Available The service life of rails depends especially on the operational loads and speeds on the railway lines, as well as on the rail maintenance policy. There are multiple aspects of rail maintenance optimization. The following article considers optimisation of rail maintenance activities relating to rail head surface condition in order to reduce corrective work on track geometry, as well as to minimize the overall costs for track maintenance. The objects of this research are issues and challenges related to rail and track maintenance in curves on modern conventional railway lines for mixed traffic.

  12. The principle of life

    International Nuclear Information System (INIS)

    Kelly, P.K.; Leinen, J.

    1982-01-01

    The chapters ''History of the movement'', ''How war against man relates to war against the environment'', ''The hurdles'', ''The strategic controversy'' point out that the slow death of mankind by the destruction of the conditions of life is certain, the sudden one by a nuclear war probable. This, of course, applies only to those who have not fallen victim to starvation before. It is something everybody knows, especially there ''in change''; yet the old jog-trot is going on. The book reports how people who fear the worst are forming a new power and advocating a change. The battle is about new majorities that have to be won. (orig./HSCH) [de

  13. Life of Science

    DEFF Research Database (Denmark)

    Engelhardt, Robin; Margot Ricard, Lykke

    Learning Lab Denmark, København. 2003 Short description: In connection to the conference Changes and Challenges the White Book "Life of Science" was published. Member states of the European Union as well as applying countries were invited to contribute to the book with texts in order to present...... inspiring cases of concrete educational strategies for improving learning, teaching and recruitment in the fields of science and technology. Abstract: The aim of this white book is to present some of the most inspiring examples of Science and Technology Education in Europe. In creating the white book, we...

  14. The software life cycle

    CERN Document Server

    Ince, Darrel

    1990-01-01

    The Software Life Cycle deals with the software lifecycle, that is, what exactly happens when software is developed. Topics covered include aspects of software engineering, structured techniques of software development, and software project management. The use of mathematics to design and develop computer systems is also discussed. This book is comprised of 20 chapters divided into four sections and begins with an overview of software engineering and software development, paying particular attention to the birth of software engineering and the introduction of formal methods of software develop

  15. Life raft stabilizer

    Science.gov (United States)

    Radnofsky, M. I.; Barnett, J. H., Jr.; Harrison, F. L.; Marak, R. J. (Inventor)

    1973-01-01

    An improved life raft stabilizer for reducing rocking and substantially precluding capsizing is discussed. The stabilizer may be removably attached to the raft and is defined by flexible side walls which extend a considerable depth downwardly to one another in the water. The side walls, in conjunction with the floor of the raft, form a ballast enclosure. A weight is placed in the bottom of the enclosure and water port means are provided in the walls. Placement of the stabilizer in the water allows the weighted bottom to sink, producing submerged deployment thereof and permitting water to enter the enclosure through the port means, thus forming a ballast for the raft.

  16. A Life of Neurotransmitters.

    Science.gov (United States)

    Snyder, Solomon H

    2017-01-06

    Development of scientific creativity is often tied closely to mentorship. In my case, two years with Julius Axelrod, the sum total of my research training, was transformative. My mentoring generations of graduate students and postdoctoral fellows has been as nurturing for me as it has been for them. Work in our lab over fifty years has covered the breadth of neurotransmitters and related substances, focusing on the discovery and characterization of novel messenger molecules. I can't conceptualize a more rewarding professional life.

  17. Periperformative Life Narrative: Queer Collages

    NARCIS (Netherlands)

    Poletti, A.L.|info:eu-repo/dai/nl/377063525

    2016-01-01

    This essay reconsiders the importance of performativity to scholarship on life writing by exploring the potential of Eve Sedgwick's concept of the periper-formative utterance for reading queer life narratives. Taking the documentary Tarnation (2003) as an example, I argue that a range of life

  18. Geography of European Life Satisfaction

    Science.gov (United States)

    Okulicz-Kozaryn, Adam

    2011-01-01

    The vast majority of studies analyze life satisfaction at individual and/or country level. This study contributes with analysis of life satisfaction at the (sub-national) province level across multiple countries. The purpose of this study is to call attention to spatial aspects of life satisfaction. Literature does not discuss the fact that life…

  19. End of Life: An Overview

    Science.gov (United States)

    Toner, Mary Ann; Shadden, Barbara B.

    2012-01-01

    Speech-language pathologists (SLPs) provide services to patients confronting the end of life (EOL) in a variety of settings. Instead of targeting improvement of health or sustaining life, EOL services focus primarily on quality of life. Although SLPs may not consider themselves core members of the health care team providing EOL services, the…

  20. Lupeol induces S-phase arrest and mitochondria-mediated ...

    Indian Academy of Sciences (India)

    48

    Lupeol induces S-phase arrest and mitochondria-mediated apoptosis in cervical cancer cells. Nupoor Prasad1, Akash Sabarwal2, Umesh C. S. Yadav1, Rana P. Singh2,*. 1School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India. 2Cancer Biology Laboratory, School of Life Sciences, Jawaharlal ...

  1. Predicting life-history adaptations to pollutants

    Energy Technology Data Exchange (ETDEWEB)

    Maltby, L. [Univ. of Sheffield (United Kingdom). Dept. of Animal and Plant Sciences

    1995-12-31

    Animals may adapt to pollutant stress so that individuals from polluted environments are less susceptible than those from unpolluted environments. In addition to such direct adaptations, animals may respond to pollutant stress by life-history modifications; so-called indirect adaptations. This paper will demonstrate how, by combining life-history theory and toxicological data, it is possible to predict stress-induced alterations in reproductive output and offspring size. Pollutant-induced alterations in age-specific survival in favor of adults and reductions in juvenile growth, conditions are predicted to select for reduced investment in reproduction and the allocation of this investment into fewer, larger offspring. Field observations on the freshwater crustaceans, Asellus aquaticus and Gammarus pulex, support these predictions. Females from metal-polluted sites had lower investment in reproduction and produced larger offspring than females of the same species from unpolluted sites. Moreover, interpopulation differences in reproductive biology persisted in laboratory cultures indicating that they had a genetic basis and were therefore due to adaptation rather than acclimation. The general applicability of this approach will be considered.

  2. Learning for life.

    Science.gov (United States)

    Fisher, N

    1989-07-01

    UNICEF's position on education availability in Africa is posited, and both recent initiatives taken on its own and those conducted through collaborative efforts with other international agencies are described. UNICEF supports the notion of learning for life, with education being accessible to all of Africa's children. Learning should be relevant and responsive to the needs of individuals and communities, helpful for surviving and developing in a dynamic environment, and emphasize their roles in the community, the nation, the work force, and the household. UNICEF supports low cost, community-based early child care and education programs, with a view to maintaining flexible approaches depending upon the types of education which may be required in different contexts. Presently, UNICEF's work in Africa centers upon communicating practical child survival and maternal health information to children, families, opinion leaders, and communicators. Collaborative efforts by UNICEF, WHO, and UNESCO include publishing a new book entitles "Facts for Life," and implementing an action-oriented school health curriculum for primary schools in 5 countries. "Health-into-Mathematics" is another UNICEF publication integrating the 2 fields for children. women in development, the importance of primary education, and the use of radio in education are also addressed. In the face of economic crisis and destabilization, education services must be protected. An initiative to promote renewed national and international commitment to basic education for all, a World Conference on Education for All-Meeting Basic Learning Needs," is noted.

  3. ENDOWMENT LIFE INSURANCE

    Directory of Open Access Journals (Sweden)

    Zeljko Sain

    2013-06-01

    Full Text Available The aim of the paper that treats the actuarial model of insurance in case of survival or early death is to show the actuarial methods and methodology for creating a model and an appropriate number of sub-models of the most popular form of life insurance in the world. The paper applies the scientific methodology of the deductive character based on scientific, theoretical knowledge and practical realities. Following the basic theoretical model’s determinants, which are at the beginning of the paper, the basic difference between models further in this paper was carried out according to the character of the premium to be paid. Finally, the financial repercussions of some models are presented at examples in insurance companies. The result of this paper is to show the spectrum of possible forms of capital endowment insurance which can be, without major problems, depending on the financial policy of the company, applied in actual practice. The conclusion of this paper shows the theoretical and the practical reality of this model, life insurance, and its quantitative and qualitative guidelines.

  4. Facets of a life

    International Nuclear Information System (INIS)

    Sakharov, A.

    1991-01-01

    This book is physicist's tribute to Andrei Dmitrievich Sakharov. This out-standing person - a talented physicist and citizen of the world - has played an extremely important role in the deep-going changes occurring in our country. His name belongs to history. Accounts of people who met him and are capable of assessing his scientific work and public activism are just beginning to pour in. In our view, this collection of reminiscences is only a small but essential, contribution to the restoration of A.D. Sakharov's image. Most of the authors, physicists, mathematicians and computer scientists from many countries, knew him as a colleague. To a varying extent, they were a part of his difficult life. This is what this collection is about. Both professional and humanistic facets of his life are described. The book begins with the texts published when he ran for a post of a people's deputy of the USSR and the biographical note printed in the Uspekhi Fizicheskikh Nauk journal after his death. They are mutually complementary for the former contains a short description of his biography and human rights activism, and the latter emphasizes Sakharov's scientific work. The authors' index contains basic data about them. The Annexes contain some previously unpublished Sakharov's documents. Among them there is 'The Letter to Soviet Scientists' with an appeal which, unfortunately, did not get the support it deserved

  5. Family life education.

    Science.gov (United States)

    Maniar, N

    1968-01-01

    Family life education is not just instruction of sex and reproduction, but an attitude of love and values that starts from infancy. A child who comes into the world wanted is already loved. Later on, he himself will give love because his 1st contact in the world was a happy one. Most children will go through thumb sucking and masturbation, which is normal and innocent behavior. Toilet training is another important factor in sex education. According to our attitude the child will learn that this part of his body is good or bad. By the age of 3 or 6, children learn to discover the difference in sex from our attitude to each other, and when parents practice double standards, the child is confused and worried. Children's curiousity for knowledge is insatiable. If parents find they are embarressed by their children's questions about sex, it is better to put off answering than to convey the impression that something is not quite nice. 11-year old females should be prepared for menarche with knowledge, and fathers should explain to their sons about voice changes, night emissions and fantasy dreams. Masturbation is normal during adolescence, and the only harm comes from wrong anxiety about it. If 2 young people wish to have premarital intercourse, we must have the courage to tell them that chastity remains a value whether they accept it or not. Education for family life means taking account of the child's attitudes and sex values as a future marriage partner and parent.

  6. Marketing in life insurance

    Directory of Open Access Journals (Sweden)

    Njegomir Vladimir

    2006-01-01

    Full Text Available Insurance industry has traditionally been oriented on sale of its products i.e. at the stage which from the aspect of marketing theory can be characterized as sales phase, phase which proceeds the marketing orientation. However, faced with numerous challenges of modern business environment such as globalization, deregulation and sophisticated information technology insurance companies must change their way of doing business. Competition is becoming fierce as insurance companies are faced with competition not only from insurance industry but also from other competitors, such as banks, that are in position to offer product substitutes for life insurance products. In this new environment information about customers and their education are becoming critical factors. Insurance companies must know their customers what influences their demand for life insurance, what is the amount of their income, what is inflation rate, their expenditures on other goods i.e. opportunity costs, etc. Those are factors that force insurance companies to concentrate more on present and potential buyers and their needs and force them to give their best to satisfy those needs in a way that will produce delighted customers.

  7. Forms of Life

    Directory of Open Access Journals (Sweden)

    Peter Hacker

    2015-10-01

    Full Text Available The phrase ‘Lebensform’ (form of life had a long and varied history prior to Wittgenstein’s use of it on a mere three occasions in the Philosophical Investigations. It is not a pivotal concept in Wittgenstein’s philosophy. But it is a minor signpost of a major reorientation of philosophy, philosophy of language and logic, and philosophy of mathematics that Wittgenstein instigated. For Wittgenstein sought to replace the conception of a language as a meaning calculus (Frege, Russell, the Tractatus by an anthropological or ethnological conception. A language is not a class of sentences that can be formed from a set of axioms (definitions, formation and transformation rules and the meanings of which is given by their truth-conditions, but an open-ended series of interlocking language-games constituting a form of life or way of living (a culture. Wittgenstein’s uses of ‘Lebensform’ and its cognates, both in the Investigations and in his Nachlass are severally analysed, and various exegetical misinterpretations are clarified.

  8. Life on Mars

    Energy Technology Data Exchange (ETDEWEB)

    Venkatavaradan, V S [Tata Inst. of Fundamental Research, Bombay (India)

    1976-10-01

    The miniature biological laboratory of the Viking-1 lander had three experiments to determine, whether the micro-organisms of the Martian soil has: (1) photo-synthetic activity (2) metabolic process activity (utilisation of nutrients) and (3) respiration. The Martian soil was warmed in an incubator and exposed to carbon dioxide (containing C/sup 14/) in presence of xenon arc lamp to simulate the Sun. If the Martian organisms of the expected type are present in the soil, the gas released during the heating would be radio-active which can be detected by a radiation counter. The three experiments had given positive signals denoting the presence of micro-organisms on the surface of Mars. The presence of superoxide in the soil would be poisonous to life but it is likely that organisms may survive deeper below the soil, where the chemicals would not be formed. The Viking-2 results also offered similar results. However, the basic question whether there is life on Mars still remains unanswered.

  9. Life on Mars

    International Nuclear Information System (INIS)

    Venkatavaradan, V.S.

    1976-01-01

    The miniature biological laboratory of the Viking-1 lander had three experiments to determine, whether the micro-organisms of the Martian soil has: (1) photo-synthetic activity (2) metabolic process activity (utilisation of nutrients) and (3) respiration. The Martian soil was warmed in an incubator and exposed to carbon dioxide (containing C 14 ) in presence of xenon arc lamp to simulate the Sun. If the Martian organisms of the expected type are present in the soil, the gas released during the heating would be radio-active which can be detected by a radiation counter. The three experiments had given positive signals denoting the presence of micro-organisms on the surface of Mars. The presence of superoxide in the soil would be poisonous to life but it is likely that organisms may survive deeper below the soil, where the chemicals would not be formed. The Viking-2 results also offered similar results. However, the basic question whether there is life on Mars still remains unanswered. (K.M.)

  10. Plant life management in Hungary

    International Nuclear Information System (INIS)

    Gillemot, F.

    1998-01-01

    The life management in Hungary is in an early stage. The preparation of a suitable database, development of maintenance systems and education of the plant and consultant staff is essential. The Act of Nuclear Safety, the introduction of the 10 years periodic safety review system (periodic licence extension) is a good basis for life management. At the same time the economic changes in the country make the life management difficult. Presently most important task is to prepare the technical environment and the methodology for NPP Life management, and within a few years, when the economy would be consolidated, a real life management will be performed

  11. Nuclear power plant life management

    International Nuclear Information System (INIS)

    Rorive, P.; Berthe, J.; Lafaille, J.P.; Eussen, G.

    1998-01-01

    Several definitions can be given to the design life of a nuclear power plant just as they can be attributed to the design life of an industrial installation: the book-keeping life which is the duration of the provision for depreciation of the plant, the licensed life which corresponds to the duration for which the plant license has been granted and beyond which a new license should be granted by the safety authorities, the design life which corresponds to the duration specified for ageing and fatigue calculations in the design of some selected components during the plant design phase, the technical life which is the duration of effective technical operation and finally the economic life corresponding to the duration of profitable operation of the plant compared with other means of electricity production. Plant life management refers to the measures taken to cope with the combination of licensed, design, technical and economical life. They can include repairs and replacements of components which have arrived to the end of their life due to known degradation processes such as fatigue, embrittlement, corrosion, wear, erosion, thermal ageing. In all cases however, it is of great importance to plan the intervention so as to minimise the economic impact. Predictive maintenance is used together with in-service inspection programs to fulfil this goal. The paper will go over the methodologies adopted in Belgium in all aspects of electrical, mechanical and civil equipment for managing plant life. (author)

  12. Radiation-induced xerostomia in a patient with nasopharyngeal ...

    African Journals Online (AJOL)

    OBJECTIVE: This study reports a case of radiation-induced xerstomia in a patient with nasopharyngeal cancer, to emphasize the need for prompt oral care to prevent untoward effects of xerostomia and to improve patients' quality of life. CASE REPORT: A 60 year old man diagnosed of radiation-induced xerostomia, after 6 ...

  13. Temporary Life Changes and the Timing of Divorce.

    Science.gov (United States)

    Fallesen, Peter; Breen, Richard

    2016-10-01

    Marriage is a risky undertaking that people enter with incomplete information about their partner and their future life circumstances. A large literature has shown how new information gained from unforeseen but long-lasting or permanent changes in life circumstances may trigger a divorce. We extend this literature by considering how information gained from a temporary change in life circumstances-in our case, a couple having a child with infantile colic-may affect divorce behavior. Although persistent life changes are known to induce divorce, we argue that a temporary stressful situation allows couples more quickly to discern the quality of their relationship, in some cases leading them to divorce sooner than they otherwise would have. We formalize this argument in a model of Bayesian updating and test it using data from Denmark. We find that the incidence of infantile colic shortens the time to divorce or disruption among couples who would have split up anyway.

  14. Psychiatry: life events and social support in late life depression

    Directory of Open Access Journals (Sweden)

    Clóvis Alexandrino-Silva

    2011-01-01

    Full Text Available OBJECTIVES: To examine the association of life events and social support in the broadly defined category of depression in late life. INTRODUCTION: Negative life events and lack of social support are associated with depression in the elderly. Currently, there are limited studies examining the association between life events, social support and late-life depression in Brazil. METHODS: We estimated the frequency of late-life depression within a household community sample of 367 subjects aged 60 years or greater with associated factors. ''Old age symptomatic depression'' was defined using the Composite International Diagnostic Interview 1.1 tool. This diagnostic category included only late-life symptoms and consisted of the diagnoses of depression and dysthymia as well as a subsyndromal definition of depression, termed ''late subthreshold depression''. Social support and life events were assessed using the Comprehensive Assessment and Referral Evaluation (SHORT-CARE inventory. RESULTS: ''Old age symptomatic depression'' occurred in 18.8% of the patients in the tested sample. In univariate analyses, this condition was associated with female gender, lifetime anxiety disorder and living alone. In multivariate models, ''old age symptomatic depression'' was associated with a perceived lack of social support in men and life events in women. DISCUSSION: Social support and life events were determined to be associated with late-life depression, but it is important to keep in mind the differences between genders. Also, further exploration of the role of lifetime anxiety disorder in late-life depression may be of future importance. CONCLUSIONS: We believe that this study helps to provide insight into the role of psychosocial factors in late-life depression.

  15. Homochirality and the origin of life

    Science.gov (United States)

    Pohl, Robert; Leitner, J. J.; Firneis, M. G.

    2012-05-01

    Homochirality is generally considered a crucial signature for life on Earth, which uses left-handed amino acids and right-handed sugars. A mirror-image life, using right-handed amino acids and left- handed sugars, is perfectly conceivable and might have developed on another planet. Life which would simultaneously use both right- and left-handed forms of the same biological molecules is unlikely for geometrical reasons. Secondary peptide structures are not possible without one-handedness. Various theories try to explain the origin of homochirality. Physicists used as argument the phenomenon of parity violation discovered on 60Co, which does not explain homochirality on prebiotic substances. Astrophysicists suggested that the observed enantiomeric excesses could have been induced by circularly polarized light arising from dust scattering in regions of high mass star formations or even due to super nova remnants or pulsars. An extraterrestrial origin of homochiral substances is discusses as well as catalytic processes on early Earth using different mineral surfaces. Thermodynamics i.e. its 2nd law is considered to explain homochirality as consequence of increasing entropy. There are many questions not yet answered. The author looks forward to discuss some of them with interested scientists.

  16. Life Span Extension and Neuronal Cell Protection by Drosophila Nicotinamidase*S⃞

    OpenAIRE

    Balan, Vitaly; Miller, Gregory S.; Kaplun, Ludmila; Balan, Karina; Chong, Zhao-Zhong; Li, Faqi; Kaplun, Alexander; VanBerkum, Mark F. A.; Arking, Robert; Freeman, D. Carl; Maiese, Kenneth; Tzivion, Guri

    2008-01-01

    The life span of model organisms can be modulated by environmental conditions that influence cellular metabolism, oxidation, or DNA integrity. The yeast nicotinamidase gene pnc1 was identified as a key transcriptional target and mediator of calorie restriction and stress-induced life span extension. PNC1 is thought to exert its effect on yeast life span by modulating cellular nicotinamide and NAD levels, resulting in increased activity of Sir2 family class III histone ...

  17. Methodology for the Life Cycle Assessment of a Car-sharing Service

    OpenAIRE

    Guyon, Olivier

    2017-01-01

    Nowadays, circular economy is becoming more relevant in society. In the context of the automotive industry, we no longer simply work on emissions emitted during the vehicle use phase but rather on the environmental impacts induced during all phases of the vehicle's life cycle (manufacturing, logistics, use, maintenance and end of life). For this purpose, many automakers, including the Group PSA, use life cycle assessment (LCA) to determine these environmental impacts. Also, the economy of sha...

  18. Gender and Working Life

    Directory of Open Access Journals (Sweden)

    Tapio Bergholm

    2011-11-01

    Full Text Available Analysis of occupational segregation by sex and gendered practices in the workplace are complex, multidimensional and contested fields of research and academic discourse. Since the 1960s, we have seen a rapid growth in both quantity and quality of academic work in this field. Earlier simplistic main (male stream as well as straightforward feminist explanations has been roundly criticised and deconstructed. It is now clear that the study of gender relations in working life is far more complicated than it was believed decades ago. The central question in gender research is how gendered structures – in which men in general have more power, more prestigious positions and higher pay – are reproduced in a world in which demography, economy, production, education and therefore society and family have changed over time. Nordic countries represents an interesting geographical arena to examine gender relations in working life, because many factors, which have been seen in other countries as causes for female subordination, appear in other forms. At present, the labour force participation rate of women in Nordic countries is nearly equal to that of men, but there are still substantial differences. Women are better educated than men, and also, to a large extent unionised. Although these factors make Nordic women stand out globally, gender equality at work or at home has not yet been achieved. The male breadwinner is still a societal norm and a construct, which conditions the behaviour of organisations and individuals in many circumstances in working life. This influence can be obvious or obscure. From the 1990s, research has turned to focus also on the fate of the male workforce during deindustrialisation and global restructuring. Participation rate of men in gainful employment have diminished in all industrialised countries (Crouch; 1999, Walby; 1997. Nordic countries are not an exception to this trend. Men’s difficulties to adapt to a new service

  19. Quality of life philosophy I. Quality of life, happiness, and meaning in life.

    Science.gov (United States)

    Ventegodt, Søren; Andersen, Niels Jørgen; Merrick, Joav

    2003-12-01

    In the Danish Quality of Life Survey, we asked 10,000 people about their quality of life with the validated SEQOL questionnaire with more than 300 questions on their quality of life. How did they feel? How content were they with their lives? How happy were they? Did they feel their needs were fulfilled? And many more questions. We asked the questions we believed to be important for their quality of life (QOL). The results were quite surprising and forced us to recontemplate the following philosophical questions: What is quality of life, happiness, and meaning in life? What is a human being? Do we need a new biology? Is the brain the seat of consciousness? How do we seize the meaning of life and by doing so, will we become well again? What are the key concepts of quality of life? The meaning of life is connectedness and development. It is about realizing every opportunity and potential in one"s existence. The opportunities must be found and acknowledged. What do you find when you find yourself deep down? You find your real self and your purpose in life. You realize that you are already a part of a larger totality. Antonovsky called it "coherence". Maslow called it "transcendence". Frankl called it "meaning of life". We call it simply "being". To test if these philosophical questions are actually relevant for medicine, we looked at the consequences for patients being taught the quality of life philosophy. Quite surprisingly we learned from our pilot studies with "quality of life as medicine" that just by assimilating the basic concepts of the quality of life philosophy presented in this series of papers, patients felt better and saw their lives as more meaningful. The improvement of the patient"s personal philosophy of life seems to be the essence of holistic medicine, helping the patient to assume more responsibility for his or her own existence.

  20. Life Shocks and Homelessness

    Science.gov (United States)

    Corman, Hope; Noonan, Kelly; Reichman, Nancy E.

    2014-01-01

    We exploited an exogenous health shock—namely, the birth of a child with a severe health condition—to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide. PMID:23868747

  1. Life shocks and homelessness.

    Science.gov (United States)

    Curtis, Marah A; Corman, Hope; Noonan, Kelly; Reichman, Nancy E

    2013-12-01

    We exploited an exogenous health shock-namely, the birth of a child with a severe health condition-to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide.

  2. Game of Life Music

    Science.gov (United States)

    Miranda, Eduardo R.; Kirke, Alexis

    At the time when the first author was post-graduate student, in the evenings he used to entertain himself with the equipment in the electronic music studio at the University of York until dawn. It must have been around three o'clock in the morning of a rather cold winter night in the late 1980s, when he connected his Atari 1040ST computer to a synthesizer to test the first prototype of a system, which he was developing for his thesis. The system, named CAMUS (short for Cellular Automata Music), implemented a method that he invented to render music from the behaviour of the Game of Life (GoL) cellular automata (CA).

  3. Recording Village Life

    DEFF Research Database (Denmark)

    Cromwell, Jennifer Adele

    and economic changes happening at both the community and country-wide levels during the early years of Islamic rule in Egypt. Additionally, they offer a fascinating picture of the scribe’s role within this world, illuminating both the practical aspects of his work and the social and professional connections......Recording Village Life presents a close study of over 140 Coptic texts written between 724–756 CE by a single scribe, Aristophanes son of Johannes, of the village Djeme in western Thebes. These texts, which focus primarily on taxation and property concerns, yield a wealth of knowledge about social...... of late antique studies, papyrology, philology, early Islamic history, social and economic history, and Egyptology....

  4. Fossil life on Mars

    Science.gov (United States)

    Walter, M. R.

    1989-01-01

    Three major problems beset paleontologists searching for morphological evidence of life on early Earth: selecting a prospective site; finding biogenic structures; and distinguishing biogenic from abiogenic structures. The same problems arise on Mars. Terrestrial experience suggests that, with the techniques that can be employed remotely, ancient springs, including hot springs, are more prospective than lake deposits. If, on the other hand, the search is for chemical evidence, the strategy can be very different, and lake deposits are attractive targets. Lakes and springs frequenly occur in close proximity, and therefore a strategy that combines the two would seem to maximize the chance of success. The strategy for a search for stromatolite on Mars is discussed.

  5. Mathematics in everyday life

    CERN Document Server

    Haigh, John

    2016-01-01

    How does mathematics impact everyday events? The purpose of this book is to show a range of examples where mathematics can be seen at work in everyday life. From money (APR, mortgage repayments, personal finance), simple first and second order ODEs, sport and games (tennis, rugby, athletics, darts, tournament design, soccer, snooker), business (stock control, linear programming, check digits, promotion policies, investment), the social sciences (voting methods, Simpson’s Paradox, drug testing, measurements of inequality) to TV game shows and even gambling (lotteries, roulette, poker, horse racing), the mathematics behind commonplace events is explored. Fully worked examples illustrate the ideas discussed and each chapter ends with a collection of exercises. Everyday Mathematics supports other first year modules by giving students extra practice in working with calculus, linear algebra, geometry, trigonometry and probability. Secondary/high school level mathematics is all that is required for students to und...

  6. Physics in daily life

    CERN Document Server

    Hermans, Jo

    2012-01-01

    This book provides answers to everyday questions that any curious mind would ask, like : Why is water blue ? What makes ice so slippery ? How do we localize sound ? How do we keep our body temperature so nice and constant ? How do we survive the sauna at 90 C ? Why do large raindrops fall faster than small ones, and what exactly is their speed ? The answers are given in an accessible and playful way, and are illustrated with funny cartoons. In this book forty "Physics in Daily Life" columns, which appeared earlier in Europhysics News, are brought together in one inspiring volume. As well as being a source of enjoyment and satisfying insights for anyone with some physics background, it also serves as a very good teaching tool for science students. This booklet is a feast of erudition and humour.

  7. A life under pressure

    DEFF Research Database (Denmark)

    Jacobsen, Jens Christian Brings; von Holstein-Rathlou, Niels-Henrik

    2012-01-01

    Microvessels live 'a life under pressure' in several ways. In a literal sense, vessels of the microcirculation are exposed to high levels of stress caused primarily by the intravascular pressure head. In a figurative sense, the individual vessel and the microvascular network as a whole must...... continuously strive to meet the changing demands of the surrounding tissue. The 'principle of optimal operation' as formulated by Y. C. Fung states that living tissues adapts structurally through remodelling and growth until a level of tensile and compressive stresses is reached at which tissue performance...... stress component has a huge impact on the state of the vascular wall. It is involved as a unifying factor on vastly different timescales in processes as diverse as acute regulation of vessel diameter, structural vessel remodelling and growth or atrophy of the vascular wall. The aim of this Mini...

  8. Contemporary family life

    DEFF Research Database (Denmark)

    Viala, Eva Silberschmidt

    2011-01-01

    to parents’ daily practices with their child. Contrary to the paradox in existing research between the ideal of gender equality on the one hand, and the differentiated and gender-based division of housework and care on the other, it is argued that changes are accruing even though parents still appear...... to adopt gender-based models when it comes to the day-to-day care and the distribution of domestic chores. Through empirical analyses it is demonstrated how the advent of the child becomes a fulcrum, and also how female and male parents’ expectations, beliefs and practises are rooted in traditional notions...... of complementary gender roles as well as in new understandings of gender equality based on ideals of mutual trust, respect and support. As a result, it is important to investigate how parenthood, family life and parental roles are constantly reflected upon and reproduced, negotiated and transformed through...

  9. [Death is also life].

    Science.gov (United States)

    Belliard, F

    1985-01-01

    A nurse at the Center for Voluntary Pregnancy Interruption and Contraception in Angers, which receives 30 abortion requests each week, describes psychological aspects of nursing care for abortion patients. Abortion patients statistically are most likely to be married women around 27 years old with husbands aged 31 on average and with 2 children. Abortions are done under local anesthesia, so that there is no hiatus between the time "before" and that "after" the procedure. Women speak about their moral and physical suffering; their choice is respected by the staff. Despite the regret or mild depression that may follow an abortion, most women experience the greatest difficulty before the procedure and feel primarily relieved afterwards. Nursing work with abortion patients consists in being open to them and accompanying them for a few hours. The patients' comfort and postabortion morbidity depend largely on the reception and understanding they are given by the staff. After the procedure, the topic of contraception is discussed with the patient. Abortion and contraception cannot be dissociated because fertility regulation involves greater well-being for all members of the family. The abortion center is a place of life in which women and couples take responsibility for their sexuality and begin again. It is important not to impose beliefs or feelings about sexuality on the patient. A training which encouraged reflection on the grand problems of life and death as well as understanding of emotions, sentiments, and reactions would be helpful in gaining self knowledge and in living through events such as abortion. A meeting with a psychiatrist every 3 weeks is arranged for all staff members who desire it in order to maintain their emotional balance and work out troubling situations encountered at work. The work at the abortion center is 1 of listening and gaining the patient's confidence in order to dedramatize the abortion and permit the woman and the couple to elect an

  10. Life on Crude Island

    International Nuclear Information System (INIS)

    Welbourn, K.; Locke, G.

    1998-01-01

    Working conditions and labour relations aboard Hibernia's offshore oil platform are described, as gathered from informal interviews with platform workers. The platform holds about 270 staff members at a time. Workers are engaged either in the production, or maintenance or the accommodations area, but opportunities to move from one area to another are good, and many workers take advantage of the opportunity to upgrade their skills. There are no roughnecks on the platform as all production work is computerized. Workers are on duty from 7 till 7, back to back, alternating day and night, three weeks on, three weeks off. All workers agree that their salaries are good, (about $ 50,000 minimum per year, plus several unique benefits), but life offshore requires many adjustments, including dealing with being separated from families for weeks at a time. Safety is the overwhelming concern of both workers and management. To go anywhere on the platform, requires written permission, and slight fluctuations in heat or light, or the leaking of a 'cupful' of oil can cause the entire plant to shut down. Anxiety about families onshore, fog and fire, the false alarms, sometimes in the middle of the night, the tight and non-descript living quarters, and the highly regulated life (no alcohol, no drugs, no gambling, no fraternizing with the 17 women on board) on this huge one million ton steel and concrete structure 315 kms from the mainland, are some of the major sources of tension. Despite these unpleasant aspects, and much grumbling, working on the Hibernia is considered a blessing by most workers. The world wants oil. People want jobs. Hibernia provides both. photos

  11. Life on Crude Island

    Energy Technology Data Exchange (ETDEWEB)

    Welbourn, K.; Locke, G.

    1998-10-01

    Working conditions and labour relations aboard Hibernia`s offshore oil platform are described, as gathered from informal interviews with platform workers. The platform holds about 270 staff members at a time. Workers are engaged either in the production, or maintenance or the accommodations area, but opportunities to move from one area to another are good, and many workers take advantage of the opportunity to upgrade their skills. There are no roughnecks on the platform as all production work is computerized. Workers are on duty from 7 till 7, back to back, alternating day and night, three weeks on, three weeks off. All workers agree that their salaries are good, (about $ 50,000 minimum per year, plus several unique benefits), but life offshore requires many adjustments, including dealing with being separated from families for weeks at a time. Safety is the overwhelming concern of both workers and management. To go anywhere on the platform, requires written permission, and slight fluctuations in heat or light, or the leaking of a `cupful` of oil can cause the entire plant to shut down. Anxiety about families onshore, fog and fire, the false alarms, sometimes in the middle of the night, the tight and non-descript living quarters, and the highly regulated life (no alcohol, no drugs, no gambling, no fraternizing with the 17 women on board) on this huge one million ton steel and concrete structure 315 kms from the mainland, are some of the major sources of tension. Despite these unpleasant aspects, and much grumbling, working on the Hibernia is considered a blessing by most workers. The world wants oil. People want jobs. Hibernia provides both. photos.

  12. Death in life or life in death? Dementia's ontological challenge.

    Science.gov (United States)

    Macdonald, Gaynor

    2018-01-01

    Is it possible to end one's life well with dementia? The perception of dementia as death brought into life flows from ideas about humanness embedded in medicine's Cartesian paradigm. Dementia as incurable brain disease exacerbates negativity. But the real impact of dementia is that it changes social relations: to live well with dementia requires a relational not Cartesian understanding of life. A relational ontology prioritizes social health: to live is to be held in connection. Negativity produces the disconnection that is death, with or without disease. When people with dementia are held in connection, they live a better life.

  13. Quality of Life Philosophy I. Quality of Life, Happiness, and Meaning in Life

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt

    2003-01-01

    Full Text Available In the Danish Quality of Life Survey, we asked 10,000 people about their quality of life with the validated SEQOL questionnaire with more than 300 questions on their quality of life. How did they feel? How content were they with their lives? How happy were they? Did they feel their needs were fulfilled? And many more questions. We asked the questions we believed to be important for their quality of life (QOL. The results were quite surprising and forced us to recontemplate the following philosophical questions: What is quality of life, happiness, and meaning in life? What is a human being? Do we need a new biology? Is the brain the seat of consciousness? How do we seize the meaning of life and by doing so, will we become well again? What are the key concepts of quality of life? The meaning of life is connectedness and development. It is about realizing every opportunity and potential in one’s existence. The opportunities must be found and acknowledged. What do you find when you find yourself deep down? You find your real self and your purpose in life. You realize that you are already a part of a larger totality. Antonovsky called it “coherence”. Maslow called it “transcendence”. Frankl called it “meaning of life”. We call it simply “being”.To test if these philosophical questions are actually relevant for medicine, we looked at the consequences for patients being taught the quality of life philosophy. Quite surprisingly we learned from our pilot studies with “quality of life as medicine” that just by assimilating the basic concepts of the quality of life philosophy presented in this series of papers, patients felt better and saw their lives as more meaningful. The improvement of the patient’s personal philosophy of life seems to be the essence of holistic medicine, helping the patient to assume more responsibility for his or her own existence.

  14. Experimentally increasing sedentary behavior results in decreased life satisfaction

    Directory of Open Access Journals (Sweden)

    Meghan K. Edwards

    2017-03-01

    behavior-inducing randomized controlled intervention on life satisfaction. Methods: Active, young adults between the ages of 18-35 were recruited and randomly assigned into a sedentary behavior intervention group (n = 26 or a control group (n = 13. The intervention group participants were instructed to eliminate all exercise and restrict daily steps (as measured via pedometry to 5000 or less per day for one week. The control group was instructed to maintain regular levels of exercise and other physical activity for one week. Both groups completed the Satisfaction with Life Scale (SWLS pre-intervention and immediately post-intervention. Results: There was a significant group x time interaction (F = 32.75, P < 0.001, with post-hoc contrast tests indicating decreased SWLS score (indicating lower levels of life satisfaction in the intervention group during Visit 2 (post-intervention compared with Visit 1 (pre-intervention; this corresponded with a mean absolute (Visit 2 minus Visit 1 change of -8.58 (95% CI: -5.91, -11.24 for SWLS scores in the intervention group (31.1% reduction. Conclusion: A one-week sedentary behavior-inducing intervention may negatively impact life satisfaction in an active, young adult population. Regular physical activity may be imperative in avoiding negative life satisfaction-related consequences.

  15. Developmental aspects of a life course approach to healthy ageing

    Science.gov (United States)

    Cooper, C.; Aihie Sayer, A.; Eendebak, R. J.; Clough, G. F.; Beard, J. R.

    2016-01-01

    Abstract We examine the mechanistic basis and wider implications of adopting a developmental perspective on human ageing. Previous models of ageing have concentrated on its genetic basis, or the detrimental effects of accumulated damage, but also have raised issues about whether ageing can be viewed as adaptive itself, or is a consequence of other adaptive processes, for example if maintenance and repair processes in the period up to reproduction are traded off against later decline in function. A life course model places ageing in the context of the attainment of peak capacity for a body system, starting in early development when plasticity permits changes in structure and function induced by a range of environmental stimuli, followed by a period of decline, the rate of which depends on the peak attained as well as the later life conditions. Such path dependency in the rate of ageing may offer new insights into its modification. Focusing on musculoskeletal and cardiovascular function, we discuss this model and the possible underlying mechanisms, including endothelial function, oxidative stress, stem cells and nutritional factors such as vitamin D status. Epigenetic changes induced during developmental plasticity, and immune function may provide a common mechanistic process underlying a life course model of ageing. The life course trajectory differs in high and low resource settings. New insights into the developmental components of the life course model of ageing may lead to the design of biomarkers of later chronic disease risk and to new interventions to promote healthy ageing, with important implications for public health. PMID:26518329

  16. LIFE CYCLE OF INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Y. S. Sennik

    2015-01-01

    Full Text Available This work is a generalization of the theoretical propositions related to the life cycle of information systems. There was given the definition of the life cycle, specify which items you should include every step of the cycle. Describes the methodology division of the life cycle on the main stage, including methodology Rational Unified Process. The description of the fundamental standards in this area. Special attention was paid to the work of the basic life cycle models. It was carried out their comparative characteristics. On the basis of the theoretical propositions, it was concluded that the preferred model of the life cycle for the corporate network is a spiral model and the use of international standards in the life cycle saves a lot of effort, time and material resources.

  17. Statistical inference on residual life

    CERN Document Server

    Jeong, Jong-Hyeon

    2014-01-01

    This is a monograph on the concept of residual life, which is an alternative summary measure of time-to-event data, or survival data. The mean residual life has been used for many years under the name of life expectancy, so it is a natural concept for summarizing survival or reliability data. It is also more interpretable than the popular hazard function, especially for communications between patients and physicians regarding the efficacy of a new drug in the medical field. This book reviews existing statistical methods to infer the residual life distribution. The review and comparison includes existing inference methods for mean and median, or quantile, residual life analysis through medical data examples. The concept of the residual life is also extended to competing risks analysis. The targeted audience includes biostatisticians, graduate students, and PhD (bio)statisticians. Knowledge in survival analysis at an introductory graduate level is advisable prior to reading this book.

  18. Plant life management at Loviisa

    International Nuclear Information System (INIS)

    Hytoenen, Y.; Savikoski, A.

    1998-01-01

    IVO, Power Engineering Ltd. has developed a company-wide approach to plant life management. The first stage of plant life management comprises operational and maintenance histories, design and plant inspection data using advanced computer systems. The life of the plant can be controlled by maintenance, refurbishment and inspection programs, and by varying the method of plant operation. On-line monitoring is needed, and cost control and training must be taken into account if the life of the plant is to be managed efficiently. Identifying the life-limiting factors is essential at Loviisa. It has been concentrated on the aging in the form of materials degradation due to fatigue, erosion, corrosion, radiation and thermal effects. Certain other life-limiting factors are also mentioned

  19. Media life of the young

    DEFF Research Database (Denmark)

    Westlund, Oscar; Bjur, Jakob

    2014-01-01

    This is a thorough investigation into contemporary young people and their media life. The article conceptualizes a typology of media life, drawing on a theoretical body involving the sociology of generations, life course research, media life and individualization. This empirically derived typology...... makes a strong instrument for an understanding of the media life of the young, furnishing insights into how they have constructed their use of media. The investigation is based on a robust national survey with Swedes born 1994–2001, conducted in 2010, and focusing on four media: television, gaming......, the Internet and mobile devices. Two of the findings are particularly surprising. Firstly, the results reveal that the young generally lead heterogeneous media lives, varying with age and sex. Secondly, although some young people literarily live their life in media, there are also de facto young who live...

  20. Managing BWR plant life extension

    International Nuclear Information System (INIS)

    Ianni, P.W.; Kiss, E.

    1985-01-01

    Recent studies have confirmed that extending the useful life of a large nuclear plant can be justified with very high cost benefit ratio. In turn, experience with large power plant systems and equipment has shown that a well-integrated and -managed plan is essential in order to achieve potential economic benefits. Consequently, General Electric's efforts have been directed at establishing a life extension plan that considers alternative options and cost-effective steps that can be taken in early life, those appropriate during middle life, and those required in late life. This paper briefly describes an approach designed to provide the plant owner a maximum of flexibility in developing a life extension plan

  1. Life history plasticity of a tropical seabird in response to El Niño anomalies during early life.

    Directory of Open Access Journals (Sweden)

    Sergio Ancona

    Full Text Available Food shortage and other challenges associated with El Niño Southern Oscillation (ENSO experienced early in life may have long-term impacts on life history traits, but these potential impacts remain virtually unexplored. By monitoring 2556 blue-footed boobies from 11 cohorts, we showed that birds facing warm water ENSO conditions (and probably low food availability in the natal year were underweight at fledging, recruited earlier and bred less frequently, but showed no deficit in longevity or breeding success over the first 10 years. Life history impacts of ENSO were substantial when experienced in the prenatal year, the natal year, or the second year of life, and absent when experienced in the third year of life, implying that harsh conditions have greater effects when experienced earlier in life. Sexual differences in impacts depended on the age when warm water conditions were experienced: pre-natal and natal experience, respectively, induced early recruitment and influenced the relationship between age and laying date only in females, whereas second year experience reduced total breeding success only of males. Most surprising were positive transgenerational impacts in females: daughters of females that experienced ENSO conditions in their natal year showed improved breeding success. Developmental plasticity of boobies thus enables them to largely neutralize potential long-term impacts of harsh climatic conditions experienced early in life.

  2. Life history plasticity of a tropical seabird in response to El Niño anomalies during early life.

    Science.gov (United States)

    Ancona, Sergio; Drummond, Hugh

    2013-01-01

    Food shortage and other challenges associated with El Niño Southern Oscillation (ENSO) experienced early in life may have long-term impacts on life history traits, but these potential impacts remain virtually unexplored. By monitoring 2556 blue-footed boobies from 11 cohorts, we showed that birds facing warm water ENSO conditions (and probably low food availability) in the natal year were underweight at fledging, recruited earlier and bred less frequently, but showed no deficit in longevity or breeding success over the first 10 years. Life history impacts of ENSO were substantial when experienced in the prenatal year, the natal year, or the second year of life, and absent when experienced in the third year of life, implying that harsh conditions have greater effects when experienced earlier in life. Sexual differences in impacts depended on the age when warm water conditions were experienced: pre-natal and natal experience, respectively, induced early recruitment and influenced the relationship between age and laying date only in females, whereas second year experience reduced total breeding success only of males. Most surprising were positive transgenerational impacts in females: daughters of females that experienced ENSO conditions in their natal year showed improved breeding success. Developmental plasticity of boobies thus enables them to largely neutralize potential long-term impacts of harsh climatic conditions experienced early in life.

  3. How Mathematics Describes Life

    Science.gov (United States)

    Teklu, Abraham

    2017-01-01

    The circle of life is something we have all heard of from somewhere, but we don't usually try to calculate it. For some time we have been working on analyzing a predator-prey model to better understand how mathematics can describe life, in particular the interaction between two different species. The model we are analyzing is called the Holling-Tanner model, and it cannot be solved analytically. The Holling-Tanner model is a very common model in population dynamics because it is a simple descriptor of how predators and prey interact. The model is a system of two differential equations. The model is not specific to any particular set of species and so it can describe predator-prey species ranging from lions and zebras to white blood cells and infections. One thing all these systems have in common are critical points. A critical point is a value for both populations that keeps both populations constant. It is important because at this point the differential equations are equal to zero. For this model there are two critical points, a predator free critical point and a coexistence critical point. Most of the analysis we did is on the coexistence critical point because the predator free critical point is always unstable and frankly less interesting than the coexistence critical point. What we did is consider two regimes for the differential equations, large B and small B. B, A, and C are parameters in the differential equations that control the system where B measures how responsive the predators are to change in the population, A represents predation of the prey, and C represents the satiation point of the prey population. For the large B case we were able to approximate the system of differential equations by a single scalar equation. For the small B case we were able to predict the limit cycle. The limit cycle is a process of the predator and prey populations growing and shrinking periodically. This model has a limit cycle in the regime of small B, that we solved for

  4. [Habitability and life support systems].

    Science.gov (United States)

    Nefedov, Iu G; Adamovich, B A

    1988-01-01

    This paper discusses various aspects of space vehicle habitability and life support systems. It describes variations in the chemical and microbial composition of an enclosed atmosphere during prolonged real and simulated flights. The paper gives a detailed description of life support systems and environmental investigations onboard the Mir station. It also outlines the development of space vehicle habitability and life support systems as related to future flights.

  5. The search for alien life

    Science.gov (United States)

    Meyer, M.

    Life on Earth relies exclusively on the complex coordination among DNA, RNA, proteins, and an encompassing cell membrane. This level of complexity has been amenable to new molecular techniques with extreme specificity and sensitivity, enabling spectacular advances in cell biology and microbial ecology. Armed with molecular techniques, the last few decades of research have revealed the surprising extent of life on our own planet, expanding the habitable range of salinity, pressure, temperature, and radiation of our world. Given the relatively recent discoveries about life on Earth, how then can we expect to look for alien life that may use completely different sets of molecules for structure and activity? Astrobiology has taken on the challenge of developing the intellectual basis, target identification, instrument capabilities, and operational procedures for the search for life elsewhere. The research aims to develop general principles of how life maintains itself, how life interacts with its environment, and how the signatures of life may be preserved and recognized. The approach has been to move from the laboratory, to the environment, to robotic exploration of planetary analogs. To date, generic evidence for life can be perceived through life's creation and utilization of disequilibria, multiple uses of a relatively few sets of molecules, a preference for chiral compounds, and a predilection for lighter isotopes. It is through application of life detection instrumentation in environmental extremes that we hope to develop a catalogue of generic biosignatures, robust instrumentation capable of revealing the unexpected, and effective exploration strategies for robotic platforms in the search for signs of life. In 2009, Mars Science Laboratory and ExoMars may be the first beneficiaries of this approach.

  6. Character profiles and life satisfaction.

    Science.gov (United States)

    Park, Hwanjin; Suh, Byung Seong; Kim, Won Sool; Lee, Hye-Kyung; Park, Seon-Cheol; Lee, Kounseok

    2015-04-01

    There is a surge of interest in subjective well-being (SWB), which concerns how individuals feel about their happiness. Life satisfaction tends to be influenced by individual psychological traits and external social factors. The aim of this study was to examine the relationship between individual character and SWB. Data from 3522 university students were analyzed in this study. Character profiles were evaluated using the Temperament and Character Inventory-Revised Short version (TCI-RS). Life satisfaction was assessed using the Satisfaction with Life Scale (SWLS). All statistical tests regarding the correlations between each character profile and life satisfaction were conducted using ANOVAs, t-tests, multiple linear regression models and correlation analyses. The creative (SCT) profile was associated with the highest levels of life satisfaction, whereas the depressive (sct) profile was associated with the lowest levels of life satisfaction. Additionally, high self-directedness, self-transcendence and cooperation were associated with high life satisfaction. The results of gender-adjusted multiple regression analysis showed that the effects of self-directedness were the strongest in the assessment of one's quality of life, followed by self-transcendence and cooperativeness, in that order. All of the three-character profiles were significantly correlated with one's quality of life, and the character profiles of TCI-RS explained 27.6% of life satisfaction in total. Among the three-character profiles, the self-directedness profile was most associated with life satisfaction. Our study was cross-sectional, and self-reported data from students at a single university were analyzed. The results of this study showed that, among the character profiles, the effects of self-directedness were the strongest for predicting life satisfaction. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. The Life of Australian Banknotes

    OpenAIRE

    Alexandra Rush

    2015-01-01

    Understanding the life of banknotes is important to a currency issuer's forward planning. Without accurate predictions of banknote life, there is a risk of incurring the economic costs of overproducing and storing excess banknotes or conversely, in an extreme case, of not being able to meet the public's demand. The life of a banknote, however, is not directly observed and must be estimated – a process complicated by the manner in which banknotes are issued and circulated. Often currency issue...

  8. The Life of Digital Photographs

    DEFF Research Database (Denmark)

    Larsen, Jonas

    )mobilities of things, practice approaches to photography and multi sited ethnography, this talk discusses and empirically track the life (the conception, birth, transformative years, ageing and death) travel, detours, makeovers and destinations of (analogue and digital) photographs in our present network societies. So...... we can understand the life of more-than representational photographs, and then I turn to my ethnographies to flesh out empirically the life of tourist photographs...

  9. Smartphones and hyper everyday life

    Directory of Open Access Journals (Sweden)

    Bernardo Amigo

    2016-07-01

    Full Text Available In this paper we present some results from our research on technological media convergence and everyday life. The results suggest that new changes would be happening on the space-temporal dimension of daily experience on people and in the way in which those give stability, structure and meaning to the intersubjective world, as a consequence of uses, appropriations and meanings about smartphones. We propose the concept of enriched everyday life or hyper everyday life in order to explain what we consider one of the principal transformations in daily life to people in the contemporary world related to the incorporation of smartphones.

  10. Water and Life on Mars

    Science.gov (United States)

    McKay, Christopher P.; DeVincenzi, Donald (Technical Monitor)

    2000-01-01

    Mars appears to be cold dry and dead world. However there is good evidence that early in its history it had liquid water, more active volcanism, and a thicker atmosphere. Mars had this earth-like environment over three and a half billion years ago, during the same time that life appeared on Earth. The main question in the exploration of Mars then is the search for a independent origin of life on that planet. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils. Although the Viking results may indicate that Mars has no life today, there is direct geomorphological evidence that, in the past, Mars had large amounts of liquid water on its surface - possibly due to a thicker atmosphere. From a biological perspective the existence of liquid water, by itself motivates the question of the origin of life on Mars. One of the martian meteorites dates back to this early period and may contain evidence consistent with life. From studies of the Earth's earliest biosphere we know that by 3.5 Gyr. ago, life had originated on Earth and reached a fair degree of biological sophistication. Surface activity and erosion on Earth make it difficult to trace the history of life before the 3.5 Gyr timeframe. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils.

  11. Is life most likely around Sun-like stars?

    Science.gov (United States)

    Lingam, Manasvi; Loeb, Abraham

    2018-05-01

    We consider the habitability of Earth-analogs around stars of different masses, which is regulated by the stellar lifetime, stellar wind-induced atmospheric erosion, and biologically active ultraviolet (UV) irradiance. By estimating the timescales associated with each of these processes, we show that they collectively impose limits on the habitability of Earth-analogs. We conclude that planets orbiting most M-dwarfs are not likely to host life, and that the highest probability of complex biospheres is for planets around K- and G-type stars. Our analysis suggests that the current existence of life near the Sun is slightly unusual, but not significantly anomalous.

  12. Schizophrenia and city life.

    Science.gov (United States)

    Lewis, G; David, A; Andréasson, S; Allebeck, P

    1992-07-18

    Prevalence of schizophrenia and rates of first admission to hospital for this disorder are higher in most modern industrialised cities, and in urban compared with rural areas. The "geographical drift" hypothesis (ie, most schizophrenics tend to drift into city areas because of their illness or its prodrome) has remained largely unchallenged. We have investigated the association between place of upbringing and the incidence of schizophrenia with data from a cohort of 49,191 male Swedish conscripts linked to the Swedish National Register of Psychiatric Care. The incidence of schizophrenia was 1.65 times higher (95% confidence interval 1.19-2.28) among men brought up in cities than in those who had had a rural upbringing. The association persisted despite adjustment for other factors associated with city life such as cannabis use, parental divorce, and family history of psychiatric disorder. This finding cannot be explained by the widely held notion that people with schizophrenia drift into cities at the beginning of their illness. We conclude that undetermined environmental factors found in cities increase the risk of schizophrenia.

  13. Life fraction rules

    International Nuclear Information System (INIS)

    Maile, K.

    1989-01-01

    Evaluations for lifetime estimation of high temperature loaded HTR-components under creep fatigue load had been performed. The evaluations were carried out on the basis of experimental data of strain controlled fatigue tests with respectively without hold times performed on material NiCr 22 Co 12 Mo (Inconel 617). Life prediction was made by means of the linear damage accumulation rule. Due to the high temperatures no realistic estimates of creep damage can be obtained with this rule. Therefore the rule was modified. The modifications consist in a different analysis of the relaxation curve including different calculation of the creep damage estimate resp. in an extended rule, taking into consideration the interaction between creep and fatigue. In order to reach a better result transparency and to reduce data set dependent result scattering a round robin with a given data set was carried out. The round robin yielded that for a given test temperature of T = 950deg C realistic estimate of damage can be obtained with each modification. Furthermore a reduction of resulting scatterbands in the interaction diagram can be observed, i.e. the practicability of the rule has been increased. (orig.)

  14. Human Life History Strategies.

    Science.gov (United States)

    Chua, Kristine J; Lukaszewski, Aaron W; Grant, DeMond M; Sng, Oliver

    2017-01-01

    Human life history (LH) strategies are theoretically regulated by developmental exposure to environmental cues that ancestrally predicted LH-relevant world states (e.g., risk of morbidity-mortality). Recent modeling work has raised the question of whether the association of childhood family factors with adult LH variation arises via (i) direct sampling of external environmental cues during development and/or (ii) calibration of LH strategies to internal somatic condition (i.e., health), which itself reflects exposure to variably favorable environments. The present research tested between these possibilities through three online surveys involving a total of over 26,000 participants. Participants completed questionnaires assessing components of self-reported environmental harshness (i.e., socioeconomic status, family neglect, and neighborhood crime), health status, and various LH-related psychological and behavioral phenotypes (e.g., mating strategies, paranoia, and anxiety), modeled as a unidimensional latent variable. Structural equation models suggested that exposure to harsh ecologies had direct effects on latent LH strategy as well as indirect effects on latent LH strategy mediated via health status. These findings suggest that human LH strategies may be calibrated to both external and internal cues and that such calibrational effects manifest in a wide range of psychological and behavioral phenotypes.

  15. Dosimetry in life sciences

    International Nuclear Information System (INIS)

    1975-01-01

    The uses of radiation in medicine and biology have grown in scope and diversity to make the Radiological Sciences a significant factor in both research and medical practice. Of critical importance in the applications and development of biomedical and radiological techniques is the precision with which the dose may be determined at all points of interest in the absorbing medium. This has developed as a result of efficacy of investigations in clinical radiation therapy, concern for patient safety and diagnostic accuracy in diagnostic radiology and the advent of clinical trials and research into the use of heavily ionizing radiations in biology and medicine. Since the last IAEA Symposium on Dosimetry Techniques applied to Agriculture, Industry, Biology and Medicine, held in Vienna in 1972, it has become increasingly clear that advances in the techniques and hardware of biomedical dosimetry have been rapid. It is for these reasons that this symposium was organized in a concerted effort to focus on the problems, developments and areas of further research in dosimetry in the Life Sciences. (author)

  16. Photonics for life.

    Science.gov (United States)

    Cubeddu, Rinaldo; Bassi, Andrea; Comelli, Daniela; Cova, Sergio; Farina, Andrea; Ghioni, Massimo; Rech, Ivan; Pifferi, Antonio; Spinelli, Lorenzo; Taroni, Paola; Torricelli, Alessandro; Tosi, Alberto; Valentini, Gianluca; Zappa, Franco

    2011-01-01

    Light is strictly connected with life, and its presence is fundamental for any living environment. Thus, many biological mechanisms are related to light interaction or can be evaluated through processes involving energy exchange with photons. Optics has always been a precious tool to evaluate molecular and cellular mechanisms, but the discovery of lasers opened new pathways of interactions of light with biological matter, pushing an impressive development for both therapeutic and diagnostic applications in biomedicine. The use of light in different fields has become so widespread that the word photonics has been utilized to identify all the applications related to processes where the light is involved. The photonics area covers a wide range of wavelengths spanning from soft X-rays to mid-infrared and includes all devices related to photons as light sources, optical fibers and light guides, detectors, and all the related electronic equipment. The recent use of photons in the field of telecommunications has pushed the technology toward low-cost, compact, and efficient devices, making them available for many other applications, including those related to biology and medicine where these requirements are of particular relevance. Moreover, basic sciences such as physics, chemistry, mathematics, and electronics have recognized the interdisciplinary need of biomedical science and are translating the most advanced researches into these fields. The Politecnico school has pioneered many of them,and this article reviews the state of the art of biomedical research at the Politecnico in the field internationally known as biophotonics.

  17. Life Sciences and employability

    Directory of Open Access Journals (Sweden)

    Wynand J. Boshoff

    2012-03-01

    Full Text Available This article addresses unemployment in rural areas. South Africa is also characterised by skills shortage and high unemployment figures, especially in rural areas as compared to urban areas. The institutional reality of education is that every rural village hosts a high school which is primarily engaged in preparing learners for further studies, whilst the Further Training Colleges (previously known as technical colleges are mainly located in the larger centres. It is with this scenario as a backdrop that the possible role of high schools to alleviate the problem is being argued. It is clear that rural employers do not expect from school leavers to be in possession of applicable knowledge, but rather to be in possession of the ability as well as certain personal characteristics that would make them employable. Unfortunately, however, this is not always found in young persons who have completed their schooling successfully. Life Sciences educators can render a valuable service should certain nontraditional approaches be incorporated into the teaching practice. This will enable them to contribute to solving one of South Africa’s serious problems.

  18. Human Life History Strategies

    Directory of Open Access Journals (Sweden)

    Kristine J. Chua

    2016-12-01

    Full Text Available Human life history (LH strategies are theoretically regulated by developmental exposure to environmental cues that ancestrally predicted LH-relevant world states (e.g., risk of morbidity–mortality. Recent modeling work has raised the question of whether the association of childhood family factors with adult LH variation arises via (i direct sampling of external environmental cues during development and/or (ii calibration of LH strategies to internal somatic condition (i.e., health, which itself reflects exposure to variably favorable environments. The present research tested between these possibilities through three online surveys involving a total of over 26,000 participants. Participants completed questionnaires assessing components of self-reported environmental harshness (i.e., socioeconomic status, family neglect, and neighborhood crime, health status, and various LH-related psychological and behavioral phenotypes (e.g., mating strategies, paranoia, and anxiety, modeled as a unidimensional latent variable. Structural equation models suggested that exposure to harsh ecologies had direct effects on latent LH strategy as well as indirect effects on latent LH strategy mediated via health status. These findings suggest that human LH strategies may be calibrated to both external and internal cues and that such calibrational effects manifest in a wide range of psychological and behavioral phenotypes.

  19. The Life within Preaching

    DEFF Research Database (Denmark)

    Gaarden, Marianne

    2017-01-01

    In my paper I will present the notion of the Third Room which can bring new perspectives in understanding how listeners create meaning when hearing the sermon. It is the result of an empirical research utilizes qualitative interviews. The encounter between the listeners’ experience and the preach......In my paper I will present the notion of the Third Room which can bring new perspectives in understanding how listeners create meaning when hearing the sermon. It is the result of an empirical research utilizes qualitative interviews. The encounter between the listeners’ experience...... and the preachers’ words facilitates a third room in which the listeners, in internal dialogue, create a surplus of meaning that was previously not present in either the preacher’s intent or the listener’s frame of reference. Thus the semantic meaning is not embedded only in the words that the preacher speaks...... but is emerging in the situation. The preacher cannot control the production of meaning, but the production of meaning is activated by the preacher which can look like a paradox. I will argue, however, that this emerging life within preaching can be considered both as a premise, a relief and a promise....

  20. Ovarian volume throughout life

    DEFF Research Database (Denmark)

    Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham

    2013-01-01

    conception to 82 years of age. This model shows that 69% of the variation in ovarian volume is due to age alone. We have shown that in the average case ovarian volume rises from 0.7 mL (95% CI 0.4-1.1 mL) at 2 years of age to a peak of 7.7 mL (95% CI 6.5-9.2 mL) at 20 years of age with a subsequent decline...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis......The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian...

  1. Self Righting Life Raft

    Science.gov (United States)

    1982-01-01

    The Givens Buoy Raft was designed and manufactured for inventor Jim Givens of Givens Marine Survival Co. Inc., by RPR Industries, Inc. The Raft consists of a canopied topside and an underwater hemispheric ballast chamber. It has a heavy ballast stabilization system, adopted from NASA technology, which negates the capsizing problem. A "flapper valve" admits large amounts of water to the hemisphere chamber providing ballast to keep the center of gravity constant; stabilization system compensates for changes in wave angle and weight shifting of raft occupants. Mr. Givens has an exclusive patent license for use of the NASA technology. Produced in various sizes, capacities range from six to 20 persons. Raft is housed in a canister, available in several configurations. A pull on a line triggers the automatic inflation process, which takes 12 seconds. The raft has been credited with saving 230 lives in the last five years. It has found wide acceptance with operators of fishing boats, pleasure craft and other vessels. The Coast Guard is purchasing the rafts for use on its rescue helicopters and the Navy has a development program to adapt the system. The Coast Guard last year announced a proposed amendment of its regulations that would require large ballast chambers on inflatable life rafts.

  2. Dosimetry in life sciences

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-06-15

    The uses of radiation in medicine and biology have grown in scope and diversity to make the Radiological Sciences a significant factor in both research and medical practice. Of critical importance in the applications and development of biomedical and radiological techniques is the precision with which the dose may be determined at all points of interest in the absorbing medium. This has developed as a result of efficacy of investigations in clinical radiation therapy, concern for patient safety and diagnostic accuracy in diagnostic radiology and the advent of clinical trials and research into the use of heavily ionizing radiations in biology and medicine. Since the last IAEA Symposium on Dosimetry Techniques applied to Agriculture, Industry, Biology and Medicine, held in Vienna in 1972, it has become increasingly clear that advances in the techniques and hardware of biomedical dosimetry have been rapid. It is for these reasons that this symposium was organized in a concerted effort to focus on the problems, developments and areas of further research in dosimetry in the Life Sciences. (author)

  3. Learning through life

    Directory of Open Access Journals (Sweden)

    Ingolf Waßmann

    2014-12-01

    Full Text Available Web 2.0 and social networks introduced impulses for novel forms of online teaching using the comprehensive interconnections of objects and users within the Internet. The diversity of existing systems complicates a holistic usage in broad learning scenarios which meet the requirements of the modern information society. This contribution presents a connectivism-based platform for online teaching called “Wiki-Learnia”, which covers the most important periods of lifelong learning. Contemporary technologies are the foundation, which not only connect users to each other but also users with dedicated contents and possibly associated authors and/or tutors. For the former, various communication tools of Web 2.0 (social networks, chats, forums, etc. are used. The latter is using the so-called “Learning Hub”, which is based on Web 3.0 mechanisms, in particular a semantic meta-search engine. To show the practical relevance of the approach the media-based Junior Studies is presented, a project of the University of Rostock with the aim of preparing pupils to be fit for university life. Based on the specific requirements of this project, the enormous function range and the great flexibility of Wiki-Learnia are demonstrated.

  4. Appraisal Of Quality Of Life Of Diabetic Patients, Including Life ...

    African Journals Online (AJOL)

    The review showed that patients with diabetes mellitus had signi cantly low ... of life (physical health, psychological health, social relations, and environment). ... of quality of life regarding gender, age, or the level of education of the patients. ... neuropathy, impaired vision, elevated blood lipids and amputation of toes or feet.

  5. Experience and Life History. Roskilde University Life History Project Paper.

    Science.gov (United States)

    Salling Olesen, Henning

    The Life History Project at Denmark's Roskilde University is a 5-year research project that was initiated in 1998 to examine learning and participation in adult and continuing education from a life history perspective. The project was designed to build on a broad range of qualitative interview studies and case studies into learning processes. The…

  6. Globalization and Life History Research: Fragments of a Life Foretold

    Science.gov (United States)

    Tierney, William G.

    2010-01-01

    The goal of this paper is to understand, by way of a life history of one low-income working-class youth, how globalization impacts the working class in a developing nation. The concept of globalization and the method of life history seem diametrically opposed. Globalization is an idea about large social forces that impact the economic and material…

  7. [Quality of life and life project, two inseparable concepts?].

    Science.gov (United States)

    Deconstanza, Patrice

    2010-01-01

    The construction of a life project within a long-stay unit for people living with chronic psychiatric disorders must take into account a dimension of care centred around the quality of life and the care provided "here and now". Here, the concept of care finds its full meaning. The example of a long-stay psychiatric unit.

  8. Extraterrestrial Life: Life on Mars - Then and Now

    Science.gov (United States)

    Arrhenius, Gustaf; Mojzsis, Stephen

    1996-01-01

    The recent claim to have identified possible signs of ancient life on Mars has been widely publicized and discussed. The authors conceded that none of the half-dozen pieces of evidence adduced in their paper individually provided strong support for extraterrestrial life, though they argued that the pieces added up to a case worth considering. Most - perhaps all - of the observed phenomena have counterparts in the inorganic world, so even the combination does not make a compelling case that there was ever life on Mars. Nevertheless, the importance of the problem has justified bringing the results to general attention. The paper has focussed interest on the origin and possible ubiquity of life, and on how we can design techniques capable of giving a more definitive answer to the question of whether there is, or has ever been, life elsewhere in the Universe.

  9. Life span extension and neuronal cell protection by Drosophila nicotinamidase.

    Science.gov (United States)

    Balan, Vitaly; Miller, Gregory S; Kaplun, Ludmila; Balan, Karina; Chong, Zhao-Zhong; Li, Faqi; Kaplun, Alexander; VanBerkum, Mark F A; Arking, Robert; Freeman, D Carl; Maiese, Kenneth; Tzivion, Guri

    2008-10-10

    The life span of model organisms can be modulated by environmental conditions that influence cellular metabolism, oxidation, or DNA integrity. The yeast nicotinamidase gene pnc1 was identified as a key transcriptional target and mediator of calorie restriction and stress-induced life span extension. PNC1 is thought to exert its effect on yeast life span by modulating cellular nicotinamide and NAD levels, resulting in increased activity of Sir2 family class III histone deacetylases. In Caenorhabditis elegans, knockdown of a pnc1 homolog was shown recently to shorten the worm life span, whereas its overexpression increased survival under conditions of oxidative stress. The function and regulation of nicotinamidases in higher organisms has not been determined. Here, we report the identification and biochemical characterization of the Drosophila nicotinamidase, D-NAAM, and demonstrate that its overexpression significantly increases median and maximal fly life span. The life span extension was reversed in Sir2 mutant flies, suggesting Sir2 dependence. Testing for physiological effectors of D-NAAM in Drosophila S2 cells, we identified oxidative stress as a primary regulator, both at the transcription level and protein activity. In contrast to the yeast model, stress factors such as high osmolarity and heat shock, calorie restriction, or inhibitors of TOR and phosphatidylinositol 3-kinase pathways do not appear to regulate D-NAAM in S2 cells. Interestingly, the expression of D-NAAM in human neuronal cells conferred protection from oxidative stress-induced cell death in a sirtuin-dependent manner. Together, our findings establish a life span extending the ability of nicotinamidase in flies and offer a role for nicotinamide-modulating genes in oxidative stress regulated pathways influencing longevity and neuronal cell survival.

  10. Life span study, 8

    International Nuclear Information System (INIS)

    Beebe, G.W.; Kato, Hiroo; Land, C.E.

    1978-02-01

    Since the last report, covering the experience of the 82,000 A-bomb survivors for the period 1950-72, there have been 1,704 deaths (by 30 September 1974) and total deaths now stand at 20,230 since 1 October 1950. For cancer the increase was 390 and the new total 3,957. The entire 1950-74 mortality experience, supplemented by tumor registry information for Hiroshima (1957-70) and Nagasaki (1958-70), has been re-analyzed. The leukemogenic effect that dominated any consideration of late mortality effects until recently had now been exceeded by the effect of radiation on forms of cancer other than leukemia. At the end of 1974 excess deaths numbered about 85 for leukemia and 100 for other forms of cancer among the 82,000 A-bomb survivors under study. Sites of cancer that seemed especially involved in the continued increase in absolute risk estimates for all forms of cancer except leukemia were the respiratory organs, and the digestive organs. Under the linear hypothesis, which is far from proved for any form of cancer, except perhaps leukemia in Hiroshima, the estimated absolute risk for all forms of cancer, including leukemia, would suggest that the A-bomb survivor population of 285,000 registrants at the time of the 1950 census may have experienced 400 or 500 deaths from cancer induced by radiation in addition to perhaps 69,000 naturally occurring deaths in the interval 1950-74. (author)

  11. Charting Ingredients for Life

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] Figure 1: Spectrum Charts Light from a Faraway Galaxy This graph, or spectrum, charts light from a faraway galaxy located 10 billion light years from Earth. It tracks mid-infrared light from an extremely luminous galaxy when the universe was only 1/4 of its current age. Spectra are created when an instrument called a spectrograph spreads light out into its basic parts, like a prism turning sunlight into a rainbow. They reveal the signatures, or 'fingerprints,' of molecules that make up a galaxy and contribute to its light. Spitzer's infrared spectrometer identified characteristic fingerprints of complex organic molecules called polycyclic aromatic hydrocarbons, illustrated in the artist's concept in the inset. These large molecules comprised of carbon and hydrogen, are considered among the building blocks of life. Scientists determined it took 10 billion years for photons from this galaxy to reach Spitzer's infrared eyes. These complex carbon and hydrogen molecules are from a young galaxy which is undergoing intense star formation, at the time the universe was only 3.5 billion years old. These distant galaxies with enormous amounts of gas being converted into young stars are some of the most luminous objects in the sky. Enshrouded by dust, they are only faint, inconspicuous little dots in optical images. They are as bright as 10 trillion suns put together and 10 times brighter than starburst galaxies seen in our local universe. This prompts a fascinating question as to what physical process is driving such enormous energy production in these galaxies when the universe is so young. These data were taken by Spitzer's infrared spectrograph in August and September 2004.

  12. INIS in My Life

    International Nuclear Information System (INIS)

    Tolstenkov, Anatoly

    2015-01-01

    The first time I learned about INIS was in 1975, when I began my career as a junior researcher at the Institute for High Energy Physics (IHEP). At that time, I could not imagine that my future life would be so closely linked to this unique system. Having begun scientific work at IHEP, I faced a serious problem of lack of access to foreign nuclear information that was a vital prerequisite for any scientific activity. At the time, there were only 3 main ways to access foreign information: the use of the Russian information system Referativnyi Zhurnal; a subscription to the leading nuclear journals such as Physical Review and Nuclear Physics; and direct personal contacts, mainly at international conferences. This was obviously insufficient, and access to pre-prints and reports was necessary, considering that at that time there was a significant time lag in published journal articles. Receiving the first magnetic tape with INIS records was a momentous occasion for scientists at my Institute. The first use of INIS information demonstrated the many innovative ideas and thoughts used to develop INIS. Obviously, at that time, there was no other nuclear information system that could compete with INIS on completeness of coverage, the volume of the information, and on the number of people involved in data collection and processing. Even now, I continue to be amazed that from the first day of operations, INIS started collecting NCL documents. As a result, the INIS NCL archive, with over 700 000 documents, was created and many of the documents from the NCL archive remain relevant to modern nuclear research

  13. Life skills and children's characterstrengths

    DEFF Research Database (Denmark)

    Ledertoug, Mette Marie; Linder, Anne

    Psychologist Anne Linder and Psychologist and PhDstudent Mette Marie Ledertoug focus in ‘Life skills and Childrens’ Character Strengths’ on improving life skills for children and adolescents by adopting a strengths-based approach combining a theoretical foundation based on VIA strengths...

  14. Life Cycle Assessment for Biofuels

    Science.gov (United States)

    A presentation based on life cycle assessment (LCA) for biofuels is given. The presentation focuses on energy and biofuels, interesting environmental aspects of biofuels, and how to do a life cycle assessment with some examples related to biofuel systems. The stages of a (biofuel...

  15. Custom Orthotics Changed My Life

    Science.gov (United States)

    Holeton, Richard

    2010-01-01

    The narrator relates his life's downward spiral and miraculous rebound from severe foot problems using animated bullet points, images, charts, and graphs. "Custom Orthotics Changed My Life" is a work of presentation fiction, or slideshow fiction, in the form of a video with an original soundtrack. The music was composed by David Kettler, a…

  16. Decomposing change in life expectancy

    DEFF Research Database (Denmark)

    Vaupel, James W.; Canudas Romo, Vladimir

    2003-01-01

    We extend Nathan Keyfitz's research on continuous change in life expectancy over time by presenting and proving a new formula for decomposing such change. The formula separates change in life expectancy over time into two terms. The first term captures the general effect of reduction in death rates...... in Sweden and Japan....

  17. Life sciences and Mars exploration

    Science.gov (United States)

    Sulzman, Frank M.; Rummel, John D.; Leveton, Lauren B.; Teeter, Ron

    1990-01-01

    The major life science considerations for Mars exploration missions are discussed. Radiation protection and countermeasures for zero gravity are discussed. Considerations of crew psychological health considerations and life support systems are addressed. Scientific opportunities presented by manned Mars missions are examined.

  18. Emissions from photovoltaic life cycles

    NARCIS (Netherlands)

    Fthenakis, V.M.; Kim, H.C.; Alsema, E.A.|info:eu-repo/dai/nl/073416258

    2008-01-01

    Photovoltaic (PV) technologies have shown remarkable progress recently in terms of annual production capacity and life cycle environmental performances, which necessitate timely updates of environmental indicators. Based on PV production data of 2004–2006, this study presents the life-cycle

  19. Life Style Assessment: So What!

    Science.gov (United States)

    Aubry, William E.

    The construct life style was used by Alfred Adler to describe the characteristic way in which individuals act and think. Followers of his theories are now collecting evidence to support or validate his contentions. The assessment of client life styles serves: (1) to make the client aware of his misconceptions, (2) as a reference point for therapy,…

  20. Evolution of complex life cycles

    NARCIS (Netherlands)

    ten Brink, J.A.

    2018-01-01

    The majority of all animal species have a metamorphosis, even though fossil evidence suggests that this life-history strategy only evolved a few times. It is thought that ontogenetic niche shifts, where individuals change their diet, habitat, and/or behaviour during their life, have been the first

  1. Roots: The Life Space Pioneers

    Science.gov (United States)

    James, Adrienne Brant

    2008-01-01

    Traditional approaches to education and youth work were transformed by two psychologists who came to the United States as Hitler rose to power. Practical theorist Kurt Lewin challenged mechanistic ideas of behavior by studying children in their natural "life space." Theory practitioner Fritz Redl applied life space concepts to work with…

  2. The Quality of Working Life.

    Science.gov (United States)

    Burke, Ronald J.

    1979-01-01

    Defines the concept "quality of working life," why interest in this has increased, and why guidance counselors and students should understand it. Quality of working life means more than job satisfaction or flexible working hours. It helps guidance teachers understand attitudes and expectations of students embarking on their first job.…

  3. Work flows in life science

    NARCIS (Netherlands)

    Wassink, I.

    2010-01-01

    The introduction of computer science technology in the life science domain has resulted in a new life science discipline called bioinformatics. Bioinformaticians are biologists who know how to apply computer science technology to perform computer based experiments, also known as in-silico or dry lab

  4. Life Role Salience and Values

    NARCIS (Netherlands)

    van Hattem, A.H.; Ossenkop, C.; Dikkers, J.S.E.; Vinkenburg, C.J.

    2013-01-01

    Purpose-Even though both values and life roles are intensively studied topics, limited research has been conducted regarding the association between the two. In the context of the Dutch public sector, this study therefore examines how life roles and values relate to each other. Moreover, the

  5. The Map of My Life

    CERN Document Server

    Shimura, Goro

    2008-01-01

    Tells about the author's life, beginning with his earliest childhood days. This book describes his survival of American bombing raids when he was a teenager in Japan, his emergence as a researcher in a post-war university system that was seriously deficient, and his life as a mathematician in Princeton and in the international academic community.

  6. Suburban areas and urban life

    DEFF Research Database (Denmark)

    Melgaard, Bente

    the cultural and urban life took place in squares, shops, cafes, etc. However, changed conditions as new forms of everyday life, the current climate and sustainability agenda, increasing social segregation, etc. give us a need to see the suburb in a new perspective. This industrial PhD project examines...

  7. Astrobiology: Life in Extreme Environments

    Science.gov (United States)

    Kaur, Preeti

    2011-01-01

    Astrobiology is the study of the origin, evolution and distribution of life in the universe. It seeks to answer two important scientific questions: how did we get here and are we alone in the universe? Scientists begin by studying life on Earth and its limits. The discovery of extremophiles on Earth capable of surviving extremes encourages the…

  8. Men, Women, and Life Annuities

    Science.gov (United States)

    King, Francis P.

    1976-01-01

    A senior research officer of Teacher Insurance and Annuity Association (TIAA) and College Retirement Equities Fund (CREF) discusses the issue of different life annuity benefits to men and women concluding that age and sex are two objective and statistically reliable factors used in determining life expectancy and thus the expected duration of…

  9. Methaemoglobinemia Induced by MDMA?

    Directory of Open Access Journals (Sweden)

    L. L. W. Verhaert

    2011-01-01

    Full Text Available Case. A 45-year-old man with a blank medical history presented at the emergency room with dizziness and cyanosis. Physical examination showed cyanosis with a peripheral saturation (SpO2 of 85%, he did not respond to supplemental oxygen. Arterial blood gas analysis showed a striking chocolate brown colour. Based on these data, we determined the arterial methaemoglobin concentration. This was 32%. We gave 100% oxygen and observed the patient in a medium care unit. The next day, patient could be discharged in good condition. Further inquiry about exhibitions and extensive history revealed that the patient used MDMA (3,4- methylenedioxymethamphetamine, the active ingredient of ecstasy. Conclusion. Acquired methaemoglobinemia is a condition that occurs infrequently, but is potentially life threatening. Different nutrients, medications, and chemicals can induce methaemoglobinemia by oxidation of haemoglobin. The clinical presentation of a patient with methaemoglobinemia is due to the impossibility of O2 binding and transport, resulting in tissue hypoxia. Important is to think about methaemoglobin in a patient who presents with cyanosis, a peripheral saturation of 85% that fails to respond properly to the administration of O2. Because methaemoglobin can be reduced physiologically, it is usually sufficient to remove the causative agent, to give O2, and to observe the patient.

  10. The Life Mission Theory II. The Structure of the Life Purpose and the Ego

    Directory of Open Access Journals (Sweden)

    Soren Ventegodt

    2003-01-01

    Full Text Available Pursuing your life mission is often very difficult, and many frustrations are experienced along the way. Major failures to bring out our potential can cause us considerable emotional pain. When this pain is unbearable, we are induced to shift from one intention and talent to another that better allows us to adapt and survive. Thus, we become set on a course that brings out a secondary or tertiary talent instead of the primary talent. This talent displacement may be expressed as a loss of our true nature or true self. The new purpose in life now functions as the core of a new personality: the ego. The ego has a structure similar to that of the true self. It is anchored in a talent and it draws on subtalents. But the person who is centered in his or her ego is not as powerful or talented as the person he or she originally was, living the primary purpose of life. This is because the original personality (the true self or “higher self” is still there, active and alive, behind the ego. Symptoms, disorders, and diseases may be explained by the loss of energy, joy in life, and intuitive competence because of inner conflicts, which may be alleviated or cured in the salutogenetic process of Antonovsky that helps patients find their sense of coherence or their primary purpose in life. Many cases of reduced ability to function, physically as well as psychologically, socially or sexually, can also be explained and alleviated in this way. When a person discovers his true talent and begins to use it with dedication, privately as well as professionally, his life will flourish and he may overcome even serious disease and great adversity in life. The salutogenetic process can also be called personal development or “quality of life as medicine”. It is important to note that the plan for personal development laid out by this theory is a plan not for the elimination of the ego, but for its cultivation. An existentially sound person still has a mental ego of

  11. Getting Acquainted in Second Life

    DEFF Research Database (Denmark)

    Pallay, Christian; Rehm, Matthias; Kurdyukova, Ekaterina

    2009-01-01

    The paper investigates human agent interactions in virtual environments like Second Life. As interactions in such environments are inherently social, the agent should be able to participate in social interaction rituals like getting acquainted when meeting someone for the first time. The differen....... The differences between these rituals in real life and in Second Life are analyzed. Different rule sets for each version of the ritual have been developed and the performance of the different sets is compared in interactions with users in Second Life.......The paper investigates human agent interactions in virtual environments like Second Life. As interactions in such environments are inherently social, the agent should be able to participate in social interaction rituals like getting acquainted when meeting someone for the first time...

  12. Life expectancy in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    OBJECTIVE: Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20 years. These calculations are based on data for individuals at the age of 15 years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later...... onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder. METHODS: Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we...... remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life-years during early and mid-adulthood. CONCLUSIONS: Life expectancy in bipolar disorder is decreased substantially, but less so than previously...

  13. Physics of the Life Sciences

    CERN Document Server

    Newman, Jay

    2008-01-01

    Originally developed for the author's course at Union College, this text is designed for life science students who need to understand the connections of fundamental physics to modern biology and medicine. Almost all areas of modern life sciences integrally involve physics in both experimental techniques and in basic understanding of structure and function. Physics of the Life Sciences is not a watered-down, algebra-based engineering physics book with sections on relevant biomedical topics added as an afterthought. This authoritative and engaging text, which is designed to be covered in a two-semester course, was written with a thoroughgoing commitment to the needs and interests of life science students. Although covering most of the standard topics in introductory physics in a more or less traditional sequence, the author gives added weight and space to concepts and applications of greater relevance to the life sciences. Students benefit from occasional sidebars using calculus to derive fundamental relations,...

  14. Life skills, wealth, health, and wellbeing in later life.

    Science.gov (United States)

    Steptoe, Andrew; Wardle, Jane

    2017-04-25

    Life skills play a key role in promoting educational and occupational success in early life, but their relevance at older ages is uncertain. Here we measured five life skills-conscientiousness, emotional stability, determination, control, and optimism-in 8,119 men and women aged 52 and older (mean 66.7 y). We show that the number of skills is associated with wealth, income, subjective wellbeing, less depression, low social isolation and loneliness, more close relationships, better self-rated health, fewer chronic diseases and impaired activities of daily living, faster walking speed, and favorable objective biomarkers (concentration of high-density lipoprotein cholesterol, vitamin D and C-reactive protein, and less central obesity). Life skills also predicted sustained psychological wellbeing, less loneliness, and a lower incidence of new chronic disease and physical impairment over a 4-y period. These analyses took account of age, sex, parental socioeconomic background, education, and cognitive function. No single life skill was responsible for the associations we observed, nor were they driven by factors such as socioeconomic status or health. Despite the vicissitudes of later life, life skills impact a range of outcomes, and the maintenance of these attributes may benefit the older population.

  15. The mental health, quality of life and life satisfaction of internally displaced persons living in Nakuru County, Kenya.

    Science.gov (United States)

    Getanda, Elijah Mironga; Papadopoulos, Chris; Evans, Hala

    2015-08-06

    Internally displaced persons (IDPs) are among the most vulnerable people in the world today. Previous research highlights that conflict-induced forced displacement can cause problems with mental health and wellbeing. This study aimed to contribute to this body of knowledge by investigating the mental health, quality of life, and life satisfaction among IDPs living in Nakuru, Kenya. A questionnaire that included the General Health Questionnaire-12, Satisfaction with Life Scale, and a modified version of the WHO Quality of Life-BREF tool was used for data collection. The questionnaire also included an open-ended question inviting qualitative responses about their experience as an IDP. The questionnaire was distributed through a three-stage sampling approach across four refugee camps from four regions of the Nakuru County in Kenya. One hundred IDPs participated in this study. All participants scored substantially higher than the applied GHQ-12 threshold for caseness (mean GHQ-12 score = 28.7, SD = 3.6). Quality of life and life satisfaction scores were also very poor (M = 10.24, SD = 1.9; M = 6.82, SD = 1.5 respectively). The qualitative results reflected these findings with statements reflecting suicidal thoughts, unhappiness with the government, lack of support, and fear for themselves and their children. Significantly higher GHQ-12 scores were found among older IDPs (rho = .202, sig = .046), widowers compared to married IDPs (mean difference = -2.41, SE = .885, sig = .027), while lower scores were found among IDPs who reported having friends as a source of support (U = 834, sig = .045), while quality of life scores were higher among IDPs who reported receiving governmental support (U = 248, sig = .018). The findings revealed poor levels of mental health, quality of life and life satisfaction. Older, widowed IDPs and those who did not perceive support from friends or the government were found to be at the highest risk of poor health and wellbeing.

  16. Energy sources, self-organization, and the origin of life.

    Science.gov (United States)

    Boiteau, Laurent; Pascal, Robert

    2011-02-01

    The emergence and early developments of life are considered from the point of view that contingent events that inevitably marked evolution were accompanied by deterministic driving forces governing the selection between different alternatives. Accordingly, potential energy sources are considered for their propensity to induce self-organization within the scope of the chemical approach to the origin of life. Requirements in terms of quality of energy locate thermal or photochemical activation in the atmosphere as highly likely processes for the formation of activated low-molecular weight organic compounds prone to induce biomolecular self-organization through their ability to deliver quanta of energy matching the needs of early biochemical pathways or the reproduction of self-replicating entities. These lines of reasoning suggest the existence of a direct connection between the free energy content of intermediates of early pathways and the quanta of energy delivered by available sources of energy.

  17. Development of fatigue life evaluation method using small specimen

    International Nuclear Information System (INIS)

    Nogami, Shuhei; Nishimura, Arata; Wakai, Eichi; Tanigawa, Hiroyasu; Itoh, Takamoto; Hasegawa, Akira

    2013-01-01

    For developing the fatigue life evaluation method using small specimen, the effect of specimen size and shape on the fatigue life of the reduced activation ferritic/martensitic steels (F82H-IEA, F82H-BA07 and JLF-1) was investigated by the fatigue test at room temperature in air using round-bar and hourglass specimens with various specimen sizes (test section diameter: 0.85–10 mm). The round-bar specimen showed no specimen size and no specimen shape effects on the fatigue life, whereas the hourglass specimen showed no specimen size effect and obvious specimen shape effect on it. The shorter fatigue life of the hourglass specimen observed under low strain ranges could be attributed to the shorter micro-crack initiation life induced by the stress concentration dependent on the specimen shape. On the basis of this study, the small round-bar specimen was an acceptable candidate for evaluating the fatigue life using small specimen

  18. Pump cavitation and inducer design

    International Nuclear Information System (INIS)

    Heslenfeld, M.W.; Hes, M. de

    2002-01-01

    Details of past work on sodium pump development and cavitation studies executed mainly for SNR 300 were reported earlier. Among the requirements for large sodium pumps are long life (200000 hours up to 300000 hours) and small size of impeller and pump, fully meeting the process and design criteria. These criteria are the required 'Q, H, r characteristics' in combination with a low NPSH value and the avoidance of cavitation damage to the pump. The pump designer has to develop a sound hydraulic combination consisting of suction arrangement, impeller design and diffuser. On the other hand the designer is free to choose an optimal pump speed. The pump speed in its turn influences the rotor dynamic pump design and the pump drive. The introduction of the inducer as an integral part of the pump design is based on following advantages: no tip cavitation; (possible) cavitation bubbles move to the open centre due to centrifugal forces on the fluid; the head of the inducer improves the inlet conditions of the impeller. The aim of an inducer is the increase in the suction specific speed (SA value) of a pump whereby the inducer functions as a pressure source improving the impeller inlet conditions. With inducer-impeller combinations values up to SA=15000 are realistic. With the use of an inducer the overall pump sizes can be reduced with Ca. 30%. Pumps commonly available have SA values up to a maximum of ca. 10000. A development programme was executed for SNR 300 in order to reach an increase of the suction specific speed of the impeller from SA 8200 to SA 11000. Further studies to optimize pumps design for the follow up line introduced the 'inducer acting as a pre-impeller' development. This programme was executed in the period 1979-1981. At the FDO premises a scale 1 2.8 inducer impeller combination with a suction specific speed SA=15000 was developed, constructed and tested at the water test rig. This water test rig is equipped with a perspex pipe allowing also visualisation

  19. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Moumita Maiti; Indian Institute of Technology Roorkee, Roorkee, Uttarakhand

    2013-01-01

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  20. Emerging technology for component life assessment

    International Nuclear Information System (INIS)

    O'Donnell, W.J.; Porowski, J.S.

    1991-01-01

    In this paper operating plant component damage and failure experience is reviewed. Loading conditions such as thermal stratification and striping, turbulent flow and flow-induced vibrations are often found to limit useful life, even though such loadings were typically not considered when the components were designed. High cycle thermal and mechanical fatigue are identified as important damage mechanisms. A new method of correlating fatigue data and extrapolating to the very high cycle regime is described. The results of environmental degradation testing during the past fifteen years have shown that such effects are much more deleterious than previously assumed. Therefore environmental and aging effects must be taken into account in evaluating the reliability and dependability of components for extended periods of operation. Since most of the available data on environmental effects focuses on measured crack growth rates, methods of developing improved fatigue life evaluation methods which include environmental effects on crack growth rates are now being developed. Fatigue tests on polished specimens are characterized by nominal stress amplitudes over yield, where linear elastic fracture mechanics (da/dn vs Δk) methods, such as those used in the ASME Code, are not valid