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Sample records for kahweol confer protection

  1. Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity

    International Nuclear Information System (INIS)

    Cárdenas, Casimiro; Quesada, Ana R.; Medina, Miguel Ángel

    2014-01-01

    Highlights: • Kahweol inhibits growth and attachment-independent proliferation of tumor cells. • Kahweol induces apoptosis in MDA-MB231 human breast cancer cells. • Kahweol-induced apoptosis involves caspase activation and cytochrome c release. • Kahweol does not protect against hydrogen peroxide cytotoxicity. • Kahweol increases hydrogen peroxide production by human breast cancer cells. - Abstract: The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene present in coffee beans, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells. In the estrogen receptor-negative MDA-MB231 human breast cancer, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release. On the other hand, kahweol increases the production of reactive oxygen species and their cytotoxicity in human breast cancer cells but not in normal cells. Taken together, our data suggest that kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA-MB231 breast cancer cells

  2. Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Cárdenas, Casimiro [Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, E-29071 Málaga (Spain); IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga (Spain); Research Support Central Services (SCAI) of the University of Málaga, E-29071 Málaga (Spain); Quesada, Ana R. [Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, E-29071 Málaga (Spain); IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga (Spain); CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga (Spain); Medina, Miguel Ángel, E-mail: medina@uma.es [Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, E-29071 Málaga (Spain); IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga (Spain); CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga (Spain)

    2014-05-09

    Highlights: • Kahweol inhibits growth and attachment-independent proliferation of tumor cells. • Kahweol induces apoptosis in MDA-MB231 human breast cancer cells. • Kahweol-induced apoptosis involves caspase activation and cytochrome c release. • Kahweol does not protect against hydrogen peroxide cytotoxicity. • Kahweol increases hydrogen peroxide production by human breast cancer cells. - Abstract: The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene present in coffee beans, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells. In the estrogen receptor-negative MDA-MB231 human breast cancer, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release. On the other hand, kahweol increases the production of reactive oxygen species and their cytotoxicity in human breast cancer cells but not in normal cells. Taken together, our data suggest that kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA-MB231 breast cancer cells.

  3. The coffee diterpene kahweol inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules in human endothelial cells

    International Nuclear Information System (INIS)

    Kim, Hyung Gyun; Kim, Ji Young; Hwang, Yong Pil; Lee, Kyung Jin; Lee, Kwang Youl; Kim, Dong Hee; Kim, Dong Hyun; Jeong, Hye Gwang

    2006-01-01

    Endothelial cells produce adhesion molecules after being stimulated with various inflammatory cytokines. These adhesion molecules play an important role in the development of atherogenesis. Recent studies have highlighted the chemoprotective and anti-inflammatory effects of kahweol, a coffee-specific diterpene. This study examined the effects of kahweol on the cytokine-induced monocyte/human endothelial cell interaction, which is a crucial early event in atherogenesis. Kahweol inhibited the adhesion of TNFα-induced monocytes to endothelial cells and suppressed the TNFα-induced protein and mRNA expression of the cell adhesion molecules, VCAM-1 and ICAM-1. Furthermore, kahweol inhibited the TNFα-induced JAK2-PI3K/Akt-NF-κB activation pathway in these cells. Overall, kahweol has anti-inflammatory and anti-atherosclerotic activities, which occurs partly by down-regulating the pathway that affects the expression and interaction of the cell adhesion molecules on endothelial cells

  4. Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma

    Directory of Open Access Journals (Sweden)

    Lee Kyung-Ae

    2012-06-01

    Full Text Available Abstract Background Malignant pleural mesothelioma (MPM is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-xl by kahweol. Conclusions Sp1 can be a novel

  5. The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.

    Science.gov (United States)

    Park, Gwang Hun; Song, Hun Min; Jeong, Jin Boo

    2016-09-01

    Kahweol as a coffee-specific diterpene has been reported to exert anti-cancer properties. However, the mechanism responsible for the anti-cancer effects of kahweol is not fully understood. The main aim of this investigation was to determine the effect of kahweol on cell proliferation and the possible mechanisms in human colorectal cancer cells. Kahweol inhibited markedly the proliferation of human colorectal cancer cell lines such as HCT116, SW480. Kahweol decreased cyclin D1 protein level in HCT116 and SW480 cells. Contrast to protein levels, cyclin D1 mRNA level and promoter activity did not be changed by kahweol treatment. MG132 treatment attenuated kahweol-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in kahweol-treated cells. Kahweol increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by kahweol. Inhibition of ERK1/2 by PD98059, JNK by SP600125 or GSK3β by LiCl suppressed cyclin D1 phosphorylation and downregulation by kahweol. Furthermore, the inhibition of nuclear export by LMB attenuated cyclin D1 degradation by kahweol. In conclusion, kahweol-mediated cyclin D1 degradation may contribute to the inhibition of the proliferation in human colorectal cancer cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers

    Directory of Open Access Journals (Sweden)

    Schouten Evert G

    2004-07-01

    Full Text Available Abstract Background Coffee oil potently raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol are responsible for this elevation. Coffee oil also causes elevation of liver enzyme levels in serum. It has been suggested that cafestol is mainly responsible for the effect on serum cholesterol levels and that kahweol is mainly responsible for the effect on liver enzyme levels. The objective of this study was to investigate whether coffee oil that only contains a minute amount of kahweol indeed does not cause elevation of liver enzyme levels. Methods The response of serum alanine aminotransferase (ALAT and aspartate aminotransferase (ASAT to Robusta coffee oil (62 mg/day cafestol, 1.6 mg/day kahweol was measured in 18 healthy volunteers. Results After nine days one subject was taken off Robusta oil treatment due to an ALAT level of 3.6 times the upper limit of normal (ULN. Another two subjects stopped treatment due to other reasons. After 16 days another two subjects were taken off Robusta oil treatment. One of those subjects had levels of 5.8 ULN for ALAT and 2.0 ULN for ASAT; the other subject had an ALAT level of 12.4 ULN and an ASAT level of 4.7 ULN. It was then decided to terminate the study. The median response of subjects to Robusta oil after 16 days was 0.27 ULN (n = 15, 25th,75th percentile: 0.09;0.53 for ALAT and 0.06 ULN (25th,75th percentile -0.06;0.22 for ASAT. Conclusions We conclude that the effect on liver enzyme levels of coffee oil containing hardly any kahweol is similar to that of coffee oil containing high amounts of kahweol. Therefore it is unlikely that kahweol is the component of coffee oil that is responsible for the effect. Furthermore, we conclude that otherwise unexplained elevation of liver enzyme levels observed in patients might be caused by a switch from consumption of filtered coffee to unfiltered coffee.

  7. Optimization of the isolation and quantitation of kahweol and cafestol in green coffee oil.

    Science.gov (United States)

    Chartier, Agnes; Beaumesnil, Mathieu; de Oliveira, Alessandra Lopes; Elfakir, Claire; Bostyn, Stephane

    2013-12-15

    Kahweol and cafestol are two diterpenes that exist mainly as esters of fatty acids in green coffee oil. To recover them under their free form they have to be either saponified or trans-esterified. These two compounds are well known to be sensitive to heat, and reagents, therefore experimental conditions used in the transesterification reaction are critical. In this paper, a Doehlert experimental design plan is used to optimize the transesterification conditions using some key variables such as the temperature of the reaction, the reagent base concentration and the duration of the reaction. Therefore, the optimal parameters determined from the Doehlert design are equal to 70 °C, temperature of the reaction; 1.25 mol L(-1) concentration of the reagent base; and 60 min reaction time. The contour plots show that the extracted quantity of kahweol and cafestol can depend greatly from the experimental conditions. After transesterification, the free form of the diterpernes is extracted from the lipid fraction using liquid-liquid extraction and analyzed using GC-FID without prior derivatization. The amount of kahweol and cafestol obtained from green coffee oil obtained by cold mechanical press of Catuai coffee bean is equal to 33.2±2.2 and 24.3±2.4 g kg(-1)oil, respectively. In an attempt to streamline the process, the transesterification reaction is performed in an in-flow chemistry reactor using the optimal conditions obtained with the Doehlert experimental design. The amount of kahweol and cafestol obtained from the same green coffee oil is equal to 43.5 and 30.072 g kg(-1)oil, respectively. Results are slightly higher compared to the ones obtained with the batch procedure. This can be explained by a better mixing of the coffee oil with the reagents and a faster transesterification reaction. © 2013 Elsevier B.V. All rights reserved.

  8. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

    International Nuclear Information System (INIS)

    Higgins, Larry G.; Cavin, Christophe; Itoh, Ken; Yamamoto, Masayuki; Hayes, John D.

    2008-01-01

    Mice fed diets containing 3% or 6% coffee for 5 days had increased levels of mRNA for NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase class Alpha 1 (GSTA1) of between 4- and 20-fold in the liver and small intestine. Mice fed 6% coffee also had increased amounts of mRNA for UDP-glucuronosyl transferase 1A6 (UGT1A6) and the glutamate cysteine ligase catalytic (GCLC) subunit of between 3- and 10-fold in the small intestine. Up-regulation of these mRNAs was significantly greater in mice possessing Nrf2 (NF-E2 p45 subunit-related factor 2) than those lacking the transcription factor. Basal levels of mRNAs for NQO1, GSTA1, UGT1A6 and GCLC were lower in tissues from nrf2 -/- mice than from nrf2 +/+ mice, but modest induction occurred in the mutant animals. Treatment of mouse embryonic fibroblasts (MEFs) from nrf2 +/+ mice with either coffee or the coffee-specific diterpenes cafestol and kahweol (C + K) increased NQO1 mRNA up to 9-fold. MEFs from nrf2 -/- mice expressed less NQO1 mRNA than did wild-type MEFs, but NQO1 was induced modestly by coffee or C + K in the mutant fibroblasts. Transfection of MEFs with nqo1-luciferase reporter constructs showed that induction by C + K was mediated primarily by Nrf2 and required the presence of an antioxidant response element in the 5'-upstream region of the gene. Luciferase reporter activity did not increase following treatment of MEFs with 100 μmol/l furan, suggesting that this ring structure within C + K is insufficient for gene induction. Priming of nrf2 +/+ MEFs, but not nrf2 -/- MEFs, with C + K conferred 2-fold resistance towards acrolein

  9. XXVII. Days of Radiation Protection. Conference Proceedings

    International Nuclear Information System (INIS)

    2005-11-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 83 papers are published

  10. Proceedings of the Tenth Radiation Physics and Protection Conference

    International Nuclear Information System (INIS)

    2011-01-01

    The publication has been set up as proceedings of the Radiation Physics and Protection Conference.. The conference consists Natural Radiation Sources; Radiation Detection and Measurements; Applied Radiation Physics; Radiation Medical Physics and Biophysics; Radiation Dosimetry; Operational Radiation Protection; Radiation Shielding; Transport of Radioactive Materials; Nuclear and Radiation Physics; Medical Physics and Public Protection Against Radiological Attack. This conference consists of 402 p., figs., tabs., refs.

  11. XXX. Days of Radiation Protection. Conference Proceedings of the 30-th Days of Radiation Protection

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-11-15

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 107 papers are published. The Conference consists of following sections: Effects of ionizing radiation; Regulation of radiation protection; Dosimetry and Metrology of ionizing radiation; Radiation protection in nuclear Power plants; Medical exposure and radiation protection in diagnostic radiology, nuclear medicine and radiation oncology; Natural radioactivity issues in radiation protection; Education, societal aspects and public involvement in radiation protection, trends and perspectives.

  12. XXX. Days of Radiation Protection. Conference Proceedings of the 30-th Days of Radiation Protection

    International Nuclear Information System (INIS)

    2008-11-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 107 papers are published. The Conference consists of following sections: Effects of ionizing radiation; Regulation of radiation protection; Dosimetry and Metrology of ionizing radiation; Radiation protection in nuclear Power plants; Medical exposure and radiation protection in diagnostic radiology, nuclear medicine and radiation oncology; Natural radioactivity issues in radiation protection; Education, societal aspects and public involvement in radiation protection, trends and perspectives

  13. 2. National scientific conference on process engineering in environment protection. Conference materials

    International Nuclear Information System (INIS)

    1994-01-01

    The national conference on 'Process engineering in environment protection' Jachranka 1994 has been divided into three sessions. Section 1 has been devoted to flue gas purification and collects 13 papers. Section 2 on liquid purification gathered 8 presentation. Section 3 - the poster session with 12 posters on related topics. During the conference 2 lectures and 3 posters have been devoted to the application of nuclear techniques to the solution different problems connected with environment protection

  14. 10. VDE/ABB lightning protection conference. Lectures

    International Nuclear Information System (INIS)

    2013-01-01

    The proceedings of the 10. VDE/ABB lightning protection conference include lectures on the following issues: Status on the standardization and resulting consequences; lightning protection of specific facilities; electrical grounding and potential equalization; lightning research; personal security and protection.

  15. Proceedings of the Seventh Radiation Physics and Protection Conference (RPC-2004)

    International Nuclear Information System (INIS)

    2005-04-01

    The Conference of radiation physics and protection was held on 27-30 November, 2004 in Egypt. the specialists discussed radiation physics and protection, fundamental radiation physics and application, Natural and man made radiation sources and radiation measurements, radiation protection and environmental, applied radiation physics, physics in medicine and biology were disscused at the conference. More than 800 papers were presented in the conference

  16. Days of Radiation Protection 2001. Conference Proceedings of the 24th Days of Radiation Protection

    International Nuclear Information System (INIS)

    Bohunice NPP

    2001-11-01

    Already the 24 th annual international conference 'Days of Protection from Radiation' was taking place in Jan Sverma Hotel in Demaenova dolina on 26-29 November 2001. More than 180 participants from the Slovak Republic and the Czech Republic participated in the meetings of experts on protection from radiation. Representative of IAEA Division for Protection from Radiation and the representatives of several European companies securing the project, advisory and supplier's activities in dosimetry of ionising radiation also participated in the conference. The participants discussed in 7 expert panels the issue of protection from radiation in the legislative field, in the nuclear facilities operation and in medicine. The expert part of the other panels concerned the issues of ionising radiation impact on the environment and working environment, natural radio-nuclides, including radon and biologic impacts of radiation. One separate panel was dedicated to device techniques and methods of dosimetry of ionising radiation. More than 45 expert lectures and more than 40 poster presentations were presented at the conference during 3 days. The exhibition and presentation of measuring technique products and devices and of materials used in the area of radiation protection and nuclear medicine was prepared during the course of the conference. Participation in the conference showed that a great interest in problems of protection from radiation persists. This was proved by rich lecturing activity and wide discussions on the floor and during the poster presentations. Participants were satisfied since the organisers of the event prepared a worthy event with the rich expert themes at a good organisational and social level in a beautiful environment of Low Tatras

  17. Proceedings of the National Conference on Radiological Protection

    International Nuclear Information System (INIS)

    2014-01-01

    The Radioprotection Argentine Society (SAR) was organized the National Conference on Radiation Protection in 2014, in order to inform to the technical and scientific community about the scopes on radiation protection. The principal treated topics were the following: radiological protection in medical applications, radiology, nuclear medicine, radiotherapy, nuclear fuel cycle, industrial gammagraphy, oil well logging.

  18. Proceedings of the Ninth Radiation Physics and Protection Conference

    International Nuclear Information System (INIS)

    2009-01-01

    The publication has been set up as proceedings of the Radiation Physics and Protection conference, the conference contains of the following subjects: Radiation Sources and Radioactive Waste; Theoretical Radiation Physics; Experimental Radiation Physics; Radiation and Nuclear Emergency; Non Ionizing Radiation; Medical Physics; Environment; Natural Radioactivity; Radiation Effect; Dosimetry; Elemental Analysis; Radiation Instruments. This conference consists of one volume and 459 pages., figs., tabs., refs

  19. Conference on the public health aspects of protection against ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-07-01

    The Conference on Public Health Aspects of Protection against Ionizing Radiation was convened by the World Health Organization at Duesseldorf, Germany, from 25 June - 4 July 1962. It was designed to examine the part which public health authorities should play in controlling the hazards of ionizing radiation, and it was attended by 63 participants from 36 countries and from a number of international organizations. The aims of the Conference were: a) to specify the role of public health services in respect of radiation protection; b) to review, on the basis of existing material and information to be made available at the Conference, the present situation of radiation protection services in different countries and to discuss desirable trends in the organization and administration of these services within the public health services; and c) to consider requirements as regards qualifications and training of public health personnel in charge of radiation protection services. The programme of the Conference centred around seven major topics: 1) ionizing radiation as a public health problem; 2) principles of public health in radiation protection; 3) review of existing laws, regulations, codes of practice and examples of radiation protection services; 4) the role of public health radiation protection services; 5) the role of public health services in planning for and dealing with emergencies (incidents and accidents); 6) qualifications and training of public health personnel in charge of radiation protection services; 7) health education of the public in the field of radiation protection.

  20. Conference on the public health aspects of protection against ionizing radiation

    International Nuclear Information System (INIS)

    1963-01-01

    The Conference on Public Health Aspects of Protection against Ionizing Radiation was convened by the World Health Organization at Duesseldorf, Germany, from 25 June - 4 July 1962. It was designed to examine the part which public health authorities should play in controlling the hazards of ionizing radiation, and it was attended by 63 participants from 36 countries and from a number of international organizations. The aims of the Conference were: a) to specify the role of public health services in respect of radiation protection; b) to review, on the basis of existing material and information to be made available at the Conference, the present situation of radiation protection services in different countries and to discuss desirable trends in the organization and administration of these services within the public health services; and c) to consider requirements as regards qualifications and training of public health personnel in charge of radiation protection services. The programme of the Conference centred around seven major topics: 1) ionizing radiation as a public health problem; 2) principles of public health in radiation protection; 3) review of existing laws, regulations, codes of practice and examples of radiation protection services; 4) the role of public health radiation protection services; 5) the role of public health services in planning for and dealing with emergencies (incidents and accidents); 6) qualifications and training of public health personnel in charge of radiation protection services; 7) health education of the public in the field of radiation protection

  1. Proceedings of the Eleventh Radiation Physics and Protection Conference

    International Nuclear Information System (INIS)

    2013-01-01

    The proceeding contains of 404 pages, the available maertial of 35 contributions: and covering of conference topics: Plenary, Invited, Keynote Talks. Nuclear Power Plant Accident. Cosmogenic Radionuclides. Waste Storage and Disposal Solutions. Radiation Medical Physics. Radiation Detection and Measurements. Radioactive in Building Materials. Radiation Protection Regulations and public Protection. Environmental Radioactivity.

  2. Proceedings: 2003 Radiation Protection Technology Conference

    International Nuclear Information System (INIS)

    2004-01-01

    Health physics professionals within the nuclear industry are continually upgrading their programs with new methods and technologies. The Third Annual EPRI Radiation Protection Technology Conference facilitated this effort by communicating technical developments, program improvements, and experience throughout the nuclear power industry. When viewed from the perspective of shorter outages, diminishing numbers of contract RP technicians and demanding emergent work, this information flow is critical for the industry

  3. The Oslo consensus conference on protection of the environment

    International Nuclear Information System (INIS)

    Oughton, D.H.; Strand, P.

    2004-01-01

    A number of international organisations are focussing on a revision of radiation protection policy from the existing system which addresses only effects on man, to one which also addresses effects on the wider environment. These developments are expected to effect a wide range of stakeholders, including industry, regulators, scientists, users and the public. With this in mind a 'Consensus Conference on Protection of the Environment' was arranged as part of an International Seminar on 'Radiation Protection in the 21st Century: Ethical, Philosophical and Environmental Issues' held at the Norwegian Academy of Science and Letters. The conference attracted 46 international experts representing various disciplines and affiliations including Environmental Science, Health Physics, Radioecology, Ethics and Philosophy and a wide spectrum of perspectives bearing on the question of radiation protection of the environment. The conference was novel in that the participants were professionals rather than laypersons, and the purpose of the consensus procedure was to identify areas of agreement as an input to the ongoing regulatory developments. The success and innovation of the model is reflected in the significant areas of agreement identified in the final consensus statement, and the subsequent interest at an international level. Participants also noted the need for furthering the debate through ongoing work. Notable issues were the harmonisation of standards for radiation with other environmental stressors, guidance for balancing different interests and values within practical management, and the need for assessment criteria

  4. International conference to explore ways to improve radiological protection of patients

    International Nuclear Information System (INIS)

    2001-01-01

    The first international conference specifically focused on the radiological protection of patients will be held in Torremolinos (Malaga), Spain, next week, from 26 to 30 March 2001. The conference, formally titled, 'International Conference on the Radiological Protection of Patients in Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy', is being organized by the IAEA, hosted by the Government of Spain and co-sponsored by the European Commission, the Pan American Health Organization and the World Health Organization. Medical applications of ionizing radiation are accepted world-wide as essential tools for keeping or restoring human health. However, they also represent by far the largest man-made source of radiation exposure. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) estimates that diagnostic medical applications of radiation account for about 95% of the exposure to radiation from man-made sources of radiation and about 12% of total exposure, which includes the exposures received from natural sources. More than 900 participants from 80 countries are expected to attend the conference. They cover a broad spectrum of expertise, including radiologists, nuclear medicine specialists, radiation oncologists, medical physicists, technologists/radiographers, radiological protection officers, equipment manufacturers, experts who develop standards for radiological equipment, hospital administrators and public health officials and representatives of professional societies. In addition, a number of patients who have undergone radiation treatment will represent patients' interests and a patient will chair one of the round table debates. The conclusions of the Conference will be incorporated into the IAEA's programme of work in the field of radiation safety and will be reported to the IAEA General Conference at its next meeting in September 2001

  5. Third conference on radiation protection and dosimetry

    International Nuclear Information System (INIS)

    1991-01-01

    This conference has been designed with the objectives of promoting communication among applied, research, regulatory, and standards personnel involved in radiation protection and providing them with sufficient information to evaluate their programs. To partly fulfill these objectives, a technical program consisting of more than 75 invited and contributed oral presentations encompassing all aspects of radiation protection has been prepared. General topics include external dosimetry, internal dosimetry, instruments, regulations and standards, accreditation and test programs, research advances, and applied program experience. This publication provides a summary of the technical program and a collection of abstracts of the oral presentations

  6. International conference on electromagnetic fields hazard protection of the human being

    International Nuclear Information System (INIS)

    Grigor'ev, Yu.G.

    1999-01-01

    The Second International conference concerning the problems of electromagnetic protection of the human being, fundamental and applied studies, normalization of the EMP: philosophy, criteria and harmonization which took place in Moscow in September 1999 is reported. The topics of reports covered both the mechanism of biological action of electromagnetic fields and aspects of impact of electromagnetic fields from various household appliances on the health of practically all modern people (television, radio, energetic, communication). The plenary section on evaluation of hazards of the mobile communication electromagnetic fields and the round table meeting dealing with evaluation of hazards of electromagnetic fields of the cellular communication base stations were conducted in the course of the conference. The plenary meetings were devoted to harmonization of the electromagnetic protection standards of Russia and western countries. The above conference constitutes one of the stages of the WHO international program concerning electromagnetic fields and the human being [ru

  7. 18th international conference on lightning protection ICLP '85. Conference proceedings. 18. internationale Blitzschutzkonferenz ICLP '85. Conference Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The proceedings contain all conference papers on the following main topics: 1) Research on thunderstorm and lightning (12 papers); 2) striking mechanism (6 papers); 3) lightning down conductors and grounding (10 papers); 4) electromagnetic lightning impulse (LEMP) and induction effects (9 papers); 5) protection of electronic systems and devices (16 papers); 6) life hazard due to lightning (9 papers).

  8. Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits.

    Science.gov (United States)

    Weiss, Shay; Kobiler, David; Levy, Haim; Marcus, Hadar; Pass, Avi; Rothschild, Nili; Altboum, Zeev

    2006-01-01

    Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to challenge with B. anthracis spores. Immunized rabbits were challenged by intranasal spore instillation with one of two virulent strains (strains Vollum and ATCC 6605). The immune competence was estimated by measuring the level of total anti-PA antibodies, the neutralizing antibody titers, and the conferred protective immunity. The results indicate that total anti-PA antibody titers greater than 1 x 10(5) conferred protection, whereas lower titers (between 10(4) and 10(5)) provided partial protection but failed to predict protection. Neutralizing antibody titers between 500 and 800 provided partial protection, while titers higher than 1,000 conferred protection. In conclusion, this study emphasizes that regardless of the immunization regimen or the time of challenge, neutralizing antibody titers are better predictors of protection than total anti-PA titers.

  9. Joint American Nuclear Society and Health Physics Society Conference: Applicability of Radiation Response Models to Low Dose Protection Standards.

    Science.gov (United States)

    Glines, Wayne M; Markham, Anna

    2018-05-01

    Seventy-five years after the Hanford Site was initially created as the primary plutonium production site for atomic weapons development under the Manhattan Project, the American Nuclear Society and the Health Physics Society are sponsoring a conference from 30 September through 3 October 2018, in Pasco, Washington, titled "Applicability of Radiation Response Models to Low Dose Protection Standards." The goal of this conference is to use current scientific data to update the approach to regulating low-level radiation doses; i.e., to answer a quintessential question of radiation protection-how to best develop radiation protection standards that protect human populations against detrimental effects while allowing the beneficial uses of radiation and radioactive materials. Previous conferences (e.g., "Wingspread Conference," "Arlie Conference") have attempted to address this question; but now, almost 20 y later, the key issues, goals, conclusions, and recommendations of those two conferences remain and are as relevant as they were then. Despite the best efforts of the conference participants and increased knowledge and understanding of the science underlying radiation effects in human populations, the bases of current radiation protection standards have evolved little. This 2018 conference seeks to provide a basis and path forward for evolving radiation protection standards to be more reflective of current knowledge and understanding of low dose response models.

  10. Proceedings of the Eigth Radiation Physics and Protection Conference (RPC-2006)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-06-15

    The publication's has been set up in 487 papers and also as electronic of the conference of Radiation Physics and Protection, it consists of the following session (1) nuclear physics; (2) neutron physics, shielding and applications; (3) radiation detection and dosimetry; (4) environmental and protection; (5) nuclear physics; (6) radiation effects; (7) medical physics and biophysics; (8) atmospheric dispersion, atomic physics; (9) radiation physics and protection awarded contribution.

  11. Proceedings of the Eigth Radiation Physics and Protection Conference (RPC-2006)

    International Nuclear Information System (INIS)

    2007-06-01

    The publication's has been set up in 487 papers and also as electronic of the conference of Radiation Physics and Protection, it consists of the following session (1) nuclear physics; (2) neutron physics, shielding and applications; (3) radiation detection and dosimetry; (4) environmental and protection; (5) nuclear physics; (6) radiation effects; (7) medical physics and biophysics; (8) atmospheric dispersion, atomic physics; (9) radiation physics and protection awarded contribution

  12. Proceedings of the second conference on radiation protection and dosimetry

    International Nuclear Information System (INIS)

    Swaja, R.E.; Sims, C.S.

    1988-11-01

    The Second Conference on Radiation Protection and Dosimetry was held during October 31--November 3, 1988, at the Holiday Inn, Crowne Plaza Hotel in Orlando, Florida. This meeting was designed with the objectives of promoting communication among applied, research, regulatory, and standards personnel involved in radiation protection and providing them with sufficient information to evaluate their programs. To facilitate meeting these objectives, a technical program consisting of more than 75 invited and contributed oral presentations encompassing all aspects of radiation protection was prepared. General topics considered in the technical sessions included external dosimetry, internal dosimetry, calibration, standards and regulations, instrumentation, accreditation and test programs, research advances, and applied program experience. In addition, special sessions were held to afford attendees the opportunity to make short presentations of recent work or to discuss topics of general interest. This document provides a summary of the conference technical program and a partial collection of full papers for the oral presentations in order of delivery. Individual papers were processed separately for the data base

  13. Proceedings of the second conference on radiation protection and dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Swaja, R. E.; Sims, C. S. [eds.

    1988-11-01

    The Second Conference on Radiation Protection and Dosimetry was held during October 31--November 3, 1988, at the Holiday Inn, Crowne Plaza Hotel in Orlando, Florida. This meeting was designed with the objectives of promoting communication among applied, research, regulatory, and standards personnel involved in radiation protection and providing them with sufficient information to evaluate their programs. To facilitate meeting these objectives, a technical program consisting of more than 75 invited and contributed oral presentations encompassing all aspects of radiation protection was prepared. General topics considered in the technical sessions included external dosimetry, internal dosimetry, calibration, standards and regulations, instrumentation, accreditation and test programs, research advances, and applied program experience. In addition, special sessions were held to afford attendees the opportunity to make short presentations of recent work or to discuss topics of general interest. This document provides a summary of the conference technical program and a partial collection of full papers for the oral presentations in order of delivery. Individual papers were processed separately for the data base.

  14. Fourth conference on radiation protection and dosimetry: Proceedings, program, and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Casson, W.H.; Thein, C.M.; Bogard, J.S. [eds.

    1994-10-01

    This Conference is the fourth in a series of conferences organized by staff members of Oak Ridge National Laboratory in an effort to improve communication in the field of radiation protection and dosimetry. Scientists, regulators, managers, professionals, technologists, and vendors from the United States and countries around the world have taken advantage of this opportunity to meet with their contemporaries and peers in order to exchange information and ideas. The program includes over 100 papers in 9 sessions, plus an additional session for works in progress. Papers are presented in external dosimetry, internal dosimetry, radiation protection programs and assessments, developments in instrumentation and materials, environmental and medical applications, and on topics related to standards, accreditation, and calibration. Individual papers are indexed separately on EDB.

  15. International conference on the protection of the environment from the effects of ionizing radiation. Contributed papers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-09-01

    An International Conference on the Protection of the Environment from the Effects of Ionizing Radiation, organized by the International Atomic Energy Agency (IAEA) in co-operation with the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), the European Commission (EC) and the International Union of Radioecology (IUR), will be held in Stockholm, Sweden, from 6-10 October 2003. This Conference will be hosted by the Government of Sweden through the Swedish Radiation Protection Authority (SSI). This publication contains contributed papers submitted on issues within the scope of the conference, which were accepted following a review by the Conference Programme Committee. The primary objective of this Conference is to foster information exchange, with the aim of promoting the development of a coherent international policy on the protection of the environment from effects attributable to ionizing radiation. This Conference is one in a series of meetings organized by, or held in co-operation with, the IAEA on this subject. It will include a review of recent developments in this area, and consideration of their implications for future work at national and international levels. The topics on which contributed papers were requested are as follows: Existing environmental protection approaches; Development of an international assessment framework; The scientific basis for environmental radiation assessment; Development of management approaches.

  16. 2. National scientific conference on process engineering in environment protection. Conference materials; 2. Ogolnopolska konferencja naukowa ``inzynieria procesowa w ochronie srodowiska``. Materialy konferencyjne

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The national conference on `Process engineering in environment protection` Jachranka 1994 has been divided into three sessions. Section 1 has been devoted to flue gas purification and collects 13 papers. Section 2 on liquid purification gathered 8 presentation. Section 3 - the poster session with 12 posters on related topics. During the conference 2 lectures and 3 posters have been devoted to the application of nuclear techniques to the solution different problems connected with environment protection.

  17. XXXIII. Days of Radiation Protection. Conference Proceedings of Abstracts; XXXIII. Dni radiacnej ochrany. Zbornik abstraktov

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 120 abstracts are published. The Conference consists of following sections: (I) Effects of ionizing radiation (radiology, health effects, risk factors); (II) General aspects of radiation protection (recommendations and legislative in radiation protection); (III): Dosimetry and metrology of ionizing radiation (metrology, instrumentation, use of computational methods); (IV) Radiation protection in nuclear power industry (working environment in the nuclear industry, the impact on the environment, nuclear power shutdown management); (V) Emergency management (emergencies, accidents, waste); (VI) Radiation load and protection in diagnostics, nuclear medicine and radiation oncology (burden on patients, staff, size of population exposure from medical sources of ionizing radiation, security, and quality control, optimization); (VII) Natural sources of radiation in workplaces and the environment (radon and other radionuclides, the risk estimation, optimization); (VIII) Education (new trends in education of radiation experts, medical physicists and stake-holders).

  18. Chemistry for protection of the environment, Eight international conference: Proceedings

    International Nuclear Information System (INIS)

    Lacy, W.J.; Pawlowski, L.; Dlugosz, J.J.

    1991-01-01

    This report presents research programs from the International Conference on the Chemistry For Protection of the Environment. Topics covered include environmental transport, waste minimization, pollution control and prevention, waste management, soil remediation, and health concerns associated with environmental contamination. Individual projects are processed separately for the data bases

  19. 2006 Chemical Biological Individual Protection (CBIP) Conference and Exhibition

    Science.gov (United States)

    2006-03-09

    Requirements Office (JRO), MAJ W. Scott Smedley , Joint Requirements Office for Chemical, Biological, Radiological, and Nuclear Defense JPEO...Decker Director of Engineering 410-436-5600 www.ecbc.army.mil Gabe Patricio, JPEO 703 681-0808 Robert Wattenbarger, JPMOIP 703 432-3198 Canadian CBRN...UNCLASSIFIED Joint Requirements Office for Chemical, Biological, and Nuclear Defense MAJ W. Scott Smedley 8 March 2006 Individual Protection Conference

  20. Proceedings: Radiation Protection Technology Conference: Providence, RI, November 2001

    International Nuclear Information System (INIS)

    2002-01-01

    Health physics (HP) professionals within the nuclear industry are continually upgrading their respective programs with new methods and technologies. The move to shorter outages combined with a diminishing group of contract HP technicians and demanding emergent work makes such changes even more important. The EPRI Radiation Protection Technology Conference focused on a number of key health physics issues and developments

  1. 1987 Oak Ridge model conference: Proceedings: Volume 2, Environmental protection

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    See the abstract for Volume I for general information on the conference. Topics discussed in Volume II include data management techiques for environmental protection efforts, the use of models in environmental auditing, in emergency plans, chemical accident emergency response, risk assessment, monitoring of waste sites, air and water monitoring of waste sites, and in training programs. (TEM)

  2. 1987 Oak Ridge model conference: Proceedings: Volume 2, Environmental protection

    International Nuclear Information System (INIS)

    1987-01-01

    See the abstract for Volume I for general information on the conference. Topics discussed in Volume II include data management techiques for environmental protection efforts, the use of models in environmental auditing, in emergency plans, chemical accident emergency response, risk assessment, monitoring of waste sites, air and water monitoring of waste sites, and in training programs

  3. A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

    NARCIS (Netherlands)

    Rivas, Manuel A.; Graham, Daniel; Sulem, Patrick; Stevens, Christine; Desch, A. Nicole; Goyette, Philippe; Gudbjartsson, Daniel; Jonsdottir, Ingileif; Thorsteinsdottir, Unnur; Degenhardt, Frauke; Mucha, Soeren; Kurki, Mitja I.; Li, Dalin; D'Amato, Mauro; Annese, Vito; Vermeire, Severine; Weersma, Rinse K.; Halfvarson, Jonas; Paavola-Sakki, Paulina; Lappalainen, Maarit; Lek, Monkol; Cummings, Beryl; Tukiainen, Taru; Haritunians, Talin; Halme, Leena; Koskinen, Lotta L. E.; Ananthakrishnan, Ashwin N.; Luo, Yang; Heap, Graham A.; Visschedijk, Marijn C.; MacArthur, Daniel G.; Neale, Benjamin M.; Ahmad, Tariq; Anderson, Carl A.; Brant, Steven R.; Duerr, Richard H.; Silverberg, Mark S.; Cho, Judy H.; Palotie, Aarno; Saavalainen, Paivi; Kontula, Kimmo; Farkkila, Martti; McGovern, Dermot P. B.; Franke, Andre; Stefansson, Kari; Rioux, John D.; Xavier, Ramnik J.; Daly, Mark J.

    Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against inflammatory bowel disease exploiting knowledge of common variants

  4. Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria

    Directory of Open Access Journals (Sweden)

    Hong Ming Huang

    2017-09-01

    Full Text Available Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate host–parasite interactions during malaria infections. In this study, we described a gene encoding erythrocytic ankyrin-1 (Ank-1 which exhibits allelic-dependent heterogeneous phenotypes during malaria infections. We conducted an ENU mutagenesis screen on mice and identified two Ank-1 mutations, one resulting in an amino acid substitution (MRI95845, and the other a truncated Ank-1 protein (MRI96570. Both mutations caused hereditary spherocytosis-like phenotypes and confer differing protection against Plasmodium chabaudi infections. Upon further examination, the Ank-1(MRI96570 mutation was found to inhibit intraerythrocytic parasite maturation, whereas Ank-1(MRI95845 caused increased bystander erythrocyte clearance during infection. This is the first description of allelic heterogeneity in ankyrin-1 from the direct comparison between two Ank-1 mutations. Despite the lack of direct evidence from population studies, this data further supported the protective roles of ankyrin-1 mutations in conferring malaria protection. This study also emphasized the importance of such phenomena in achieving a better understanding of host–parasite interactions, which could be the basis of future studies.

  5. Patients radiation protection in medical imaging. Conference proceedings

    International Nuclear Information System (INIS)

    2011-12-01

    This document brings together the available presentations given at the conference organised by the French society of radiation protection about patients radiation protection in medical imaging. Twelve presentations (slides) are compiled in this document and deal with: 1 - Medical exposure of the French population: methodology and results (Bernard Aubert, IRSN); 2 - What indicators for the medical exposure? (Cecile Etard, IRSN); 3 - Guidebook of correct usage of medical imaging examination (Philippe Grenier, Pitie-Salpetriere hospital); 4 - Radiation protection optimization in pediatric imaging (Hubert Ducou-Le-Pointe, Aurelien Bouette (Armand-Trousseau children hospital); 5 - Children's exposure to image scanners: epidemiological survey (Marie-Odile Bernier, IRSN); 6 - Management of patient's irradiation: from image quality to good practice (Thierry Solaire, General Electric); 7 - Dose optimization in radiology (Cecile Salvat (Lariboisiere hospital); 8 - Cancer detection in the breast cancer planned screening program - 2004-2009 era (Agnes Rogel, InVS); 9 - Mammographic exposures - radiobiological effects - radio-induced DNA damages (Catherine Colin, Lyon Sud hospital); 10 - Breast cancer screening program - importance of non-irradiating techniques (Anne Tardivon, Institut Curie); 11 - Radiation protection justification for the medical imaging of patients over the age of 50 (Michel Bourguignon, ASN); 12 - Search for a molecular imprint for the discrimination between radio-induced and sporadic tumors (Sylvie Chevillard, CEA)

  6. The Report of the National Invitational Conference on Consumer Protection in Postsecondary Education. Report No. 53.

    Science.gov (United States)

    Education Commission of the States, Denver, CO.

    This report covers the background, major issues, major recommendations, and agencies and associations represented at the National Invitational Conference on Consumer Protection in Postsecondary Education held at Denver, Colorado in June 1974. Major recommendations of the conference suggest that: (1) The states should provide by legislation or by…

  7. Proceedings of the third conference on radiation protection and dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Swaja, R.E.; Sims, C.S.; Casson, W.H. [eds.

    1991-10-01

    The Third Conference on Radiation Protection and Dosimetry was held during October 21--24, 1991, at the Sheraton Plaza Hotel in Orlando, Florida. This meeting was designed with the objectives of promoting communication among applied, research, regulatory, and standards personnel involved in radiation protection, and providing them with sufficient information to evaluate their programs. To meet these objectives, a technical program consisting of more than 75 invited and contributed oral presentations encompassing all aspects of radiation protection was prepared. General topics considered in the technical session included external dosimetry, internal dosimetry, instruments, accident dosimetry, regulations and standards, research advances, and applied program experience. In addition, special sessions were held to afford attendees the opportunity to make short presentations of recent work or to discuss topics of general interest. Individual reports are processed separately on the database.

  8. Proceedings of the third conference on radiation protection and dosimetry

    International Nuclear Information System (INIS)

    Swaja, R.E.; Sims, C.S.; Casson, W.H.

    1991-10-01

    The Third Conference on Radiation Protection and Dosimetry was held during October 21--24, 1991, at the Sheraton Plaza Hotel in Orlando, Florida. This meeting was designed with the objectives of promoting communication among applied, research, regulatory, and standards personnel involved in radiation protection, and providing them with sufficient information to evaluate their programs. To meet these objectives, a technical program consisting of more than 75 invited and contributed oral presentations encompassing all aspects of radiation protection was prepared. General topics considered in the technical session included external dosimetry, internal dosimetry, instruments, accident dosimetry, regulations and standards, research advances, and applied program experience. In addition, special sessions were held to afford attendees the opportunity to make short presentations of recent work or to discuss topics of general interest. Individual reports are processed separately on the database

  9. The Report of the Second National Conference on Consumer Protection in Postsecondary Education. Report No. 64.

    Science.gov (United States)

    Education Commission of the States, Denver, CO.

    The second National Conference on Consumer Protection in Postsecondary Education was a series of seminars on specific issues. The topics under discussion were (1) protecting the student financial interest; (2) student information needs and systems; (3) postsecondary education institutional responses; (4) regulations and safeguards; and (5) full…

  10. International Conference of Ukrainian Nuclear Society ''NPP's safety and protection''(annotations)

    International Nuclear Information System (INIS)

    Barbashev, S.V.

    1997-01-01

    The abstracts of reports submitted to the Conference include: - New developments of the safe nuclear installations; - NPP ecological safety; - Methods of personnel and population protection; - Waste management safety (at transportation, processing and storage); - Spent nuclear fuel management; - NPP life extension and decommissioning; - Public opinion as an element of NPP safety; - Training of personnel, scientific support and safety culture; - Forecasting of nuclear power and industry safe development; - Development of international cooperation in nuclear power

  11. Stockholm Safety Conference. Analysis of the sessions on radiological protection, licensing and risk assessment

    International Nuclear Information System (INIS)

    Gea, A.

    1981-01-01

    A summary of the sessions on radiological protection, licensing and risk assessment in the safety conference of Stockholm is presented. It is considered the new point of view of the nuclear safety, probabilistic analysis, components failures probability and accident analysis. They are included conclusions applicable in many cases to development countries. (author)

  12. The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.

    Science.gov (United States)

    Elahi, Shokrollah; Buchanan, Rachelle M; Attah-Poku, Sam; Townsend, Hugh G G; Babiuk, Lorne A; Gerdts, Volker

    2006-04-01

    Innate immunity plays an important role in protection against respiratory infections in humans and animals. Host defense peptides such as beta-defensins represent major components of innate immunity. We recently developed a novel porcine model of pertussis, an important respiratory disease of young children and infants worldwide. Here, we investigated the role of porcine beta-defensin 1 (pBD-1), a porcine defensin homologue of human beta-defensin 2, in conferring protection against respiratory infection with Bordetella pertussis. In this model, newborn piglets were fully susceptible to infection and developed severe bronchopneumonia. In contrast, piglets older than 4 weeks of age were protected against infection with B. pertussis. Protection was associated with the expression of pBD-1 in the upper respiratory tract. In fact, pBD-1 expression was developmentally regulated, and the absence of pBD-1 was thought to contribute to the increased susceptibility of newborn piglets to infection with B. pertussis. Bronchoalveolar lavage specimens collected from older animals as well as chemically synthesized pBD-1 displayed strong antimicrobial activity against B. pertussis in vitro. Furthermore, in vivo treatment of newborn piglets with only 500 mug pBD-1 at the time of challenge conferred protection against infection with B. pertussis. Interestingly, pBD-1 displayed no bactericidal activity in vitro against Bordetella bronchiseptica, a closely related natural pathogen of pigs. Our results demonstrate that host defense peptides play an important role in protection against pertussis and are essential in modulating innate immune responses against respiratory infections.

  13. Papers of All-Polish Conference on Nuclear Techniques in Industry, Medicine, Agriculture and Environmental Protection

    International Nuclear Information System (INIS)

    2002-01-01

    These proceedings comprise papers presented at All-Polish Conference on nuclear techniques in industry, medicine, agriculture and environmental protection. Most of the papers are in the field of uses of radiation sources and particle beams in industry, radiation chemistry, nuclear medicine and dosimetry, environmental sciences

  14. The main findings of the third Russian international conference on nuclear material protection, control and accounting, Obninsk, RF, 16-20 May, 2005

    International Nuclear Information System (INIS)

    Kondratov, S.

    2005-01-01

    Full text: The first and the second Russian international conferences on MPC+A held in 1997 and 2000 correspondingly, under the Russian-American program of the MPC+A cooperation proved to be a useful tool for Russian, American specialists and experts from a number for sharing their opinions and exchanging achievements in this sensitive area. The recommendation to hold the next third MPC+A conference in Russia was formulated in the final document of the second conference in 2000. The results of the Russian-American cooperation are especially valuable since they demonstrate how much can be done due to the joint efforts of even previously adversarial countries. This paper gives a summary of the main findings of the third Russian conference on the MPC+A with a specific emphasis on physical protection of the Russian nuclear materials and nuclear facilities. Besides the physical protection, materials accounting, education and training of personnel, security culture and some other associated topics of the conference are also addressed. (author)

  15. Variability of some diterpene esters in coffee beverages as influenced by brewing procedures.

    Science.gov (United States)

    Moeenfard, Marzieh; Erny, Guillaume L; Alves, Arminda

    2016-11-01

    Several coffee brews, including classical and commercial beverages, were analyzed for their diterpene esters content (cafestol and kahweol linoleate, oleate, palmitate and stearate) by high performance liquid chromatography with diode array detector (HPLC-DAD) combined with spectral deconvolution. Due to the coelution of cafestol and kahweol esters at 225 nm, HPLC-DAD did not give accurate quantification of cafestol esters. Accordingly, spectral deconvolution was used to deconvolve the co-migrating profiles. Total cafestol and kahweol esters content of classical coffee brews ranged from 5-232 to 2-1016 mg/L, respectively. Commercial blends contained 1-54 mg/L of total cafestol esters and 2-403 mg/L of total kahweol esters. Boiled coffee had the highest diterpene esters content, while filtered and instant brews showed the lowest concentrations. However, individual diterpene esters content was not affected by brewing procedure as in terms of kahweol esters, kahweol palmitate was the main compound in all samples, followed by kahweol linoleate, oleate and stearate. Higher amounts of cafestol palmitate and stearate were also observed compared to cafestol linoleate and cafestol oleate. The ratio of diterpene esters esterified with unsaturated fatty acids to total diterpene esters was considered as measure of their unsaturation in analyzed samples which varied from 47 to 52%. Providing new information regarding the diterpene esters content and their distribution in coffee brews will allow a better use of coffee as a functional beverage.

  16. Obstacles to hydroelectric power. VDI conference on chances of hydroelectric power - conservation and environmental protection in conflict

    International Nuclear Information System (INIS)

    Sauer, H.D.

    1994-01-01

    Hydroelectric power is one of the most efficient energy sources and presents no CO 2 pollution problem, but there are obstacles as was shown at a VDI conference. Regional landscape conservation interests are in conflict with global environmental protection considerations. (orig.) [de

  17. International Conference on Recent Developments and Applications of Nuclear Technologies - Conference Abstracts

    International Nuclear Information System (INIS)

    Zakrzewska-Trznadel, G.

    2008-01-01

    The aim of the Conference was to offer an opportunity to interchange views and experiences, as well as to present the state of the art and modern trends concerning research and applications in the field of nuclear technologies. It was hoped that the Conference may fill up the gap on the field of information about possibilities and results of the application of nuclear technologies in modern economy of the 21 century, particularly in: industry, food processing, heritage preservation, environmental protection, homeland security and health protection. One session, with invited lectures, was entirely devoted to modern nuclear technologies for power generation. Conference participants presented 7 plenary lectures, 68 oral communications in 8 sessions and 98 posters

  18. Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo

    Directory of Open Access Journals (Sweden)

    Evelyne M Houang

    Full Text Available Duchenne muscular dystrophy (DMD is a fatal disease of striated muscle deterioration. A unique therapeutic approach for DMD is the use of synthetic membrane stabilizers to protect the fragile dystrophic sarcolemma against contraction-induced mechanical stress. Block copolymer-based membrane stabilizer poloxamer 188 (P188 has been shown to protect the dystrophic myocardium. In comparison, the ability of synthetic membrane stabilizers to protect fragile DMD skeletal muscles has been less clear. Because cardiac and skeletal muscles have distinct structural and functional features, including differences in the mechanism of activation, variance in sarcolemma phospholipid composition, and differences in the magnitude and types of forces generated, we speculated that optimized membrane stabilization could be inherently different. Our objective here is to use principles of pharmacodynamics to evaluate membrane stabilization therapy for DMD skeletal muscles. Results show a dramatic differential effect of membrane stabilization by optimization of pharmacodynamic-guided route of poloxamer delivery. Data show that subcutaneous P188 delivery, but not intravascular or intraperitoneal routes, conferred significant protection to dystrophic limb skeletal muscles undergoing mechanical stress in vivo. In addition, structure-function examination of synthetic membrane stabilizers further underscores the importance of copolymer composition, molecular weight, and dosage in optimization of poloxamer pharmacodynamics in vivo.

  19. Eighth meeting of the radiation protection-skilled persons - Conference proceedings

    International Nuclear Information System (INIS)

    Juhel, Thierry; Lahaye, Thierry; Rousse, Carole; Perrin, Marie-Line; Billarand, Yann; Scanff, Pascale; Celier, David; El Jammal, Marie-Helene; Jacob, Sophie; Vecchiola, Sophie; Bulla, Giuseppina; Guillalmon, Christophe; Mechin, Guillaume; Guersen, Joel; Blaise, Philipp; Ammerich, Marc; Bordy, Jean-Marc; Sevestre, Bernard; Massiot, Philippe; Michel, Xavier; Raffoux, Yann; Kernisant, Billy; Lefaure, Christian; Balduyck, Sebastien; Wassilieff, Serge; Ouabdelkader, Said; Lecu, Alexis; Roy, Catherine; Pigree, Gilbert; Barbey, Pierre; Bergeron, Christophe; Schieber, Caroline

    2012-12-01

    This eighth meeting of the radiation protection skilled persons celebrated the 15. anniversary of this type of meetings. It is the occasion for radiation protection specialists to share information and their experience on various topics, in particular the recent evolutions of the regulation. This document gathers the available presentations given during this conference: 1 - Opening talk (T. Juhel); 2 - Regulatory evolutions in the domain of protection of workers exposed to ionising radiations (T. Lahaye); 3 - Evolution of the regulatory documents on the basis of the French public health law (C. Rousse); 4 - Relations between IRSN and Companies - regulatory obligations from the perspective of the radiation protection-skilled person (Y. Billarand); 5 - IRSN's follow up of workers' exposure (P. Scanff); 6 - Contribution of a 18 F preparation and injection system to the radiation protection of workers (D. Celier); 7 - Workplace analysis in interventional radiology (G. Bulla, C. Guillalmon); 8 - Interest of Workplace analyses in risk information (G. Mechin); 9 - Running of a joint operators/contractors club of radiation protection skilled persons at the scale of a CEA centre (P. Blaise); 10 - Radiological exposure of the maintenance personnel of aerial monitoring radars (X. Michel); 11 - The IRSN barometer (M.H. El Jammal); 12 - An original network of professional radiation protection: the GoogleGroup for dental radiation protection-skilled persons (Y. Raffoux); 13 - Cirkus radiation protection association - a portal for a practical and operational radiation protection (B. Kernisant); 14 - Situation of networks - what do we do in a network? What is the role of the national coordination? (S. Balduyck, C. Lefaure); 15 - Update on the situation at Fukushima (M. Ammerich); 15 - Radio-induced cataracts: why lowering the eye lens legal limit? (S. Wassilieff); 16 - O'CLOC study - Radio-induced cataracts among interventional Cardiologists (S. Jacob); 17 - Photon dosimetry of

  20. Immunization with plasmid DNA encoding the hemagglutinin and the nucleoprotein confers robust protection against a lethal canine distemper virus challenge.

    Science.gov (United States)

    Dahl, Lotte; Jensen, Trine Hammer; Gottschalck, Elisabeth; Karlskov-Mortensen, Peter; Jensen, Tove Dannemann; Nielsen, Line; Andersen, Mads Klindt; Buckland, Robin; Wild, T Fabian; Blixenkrone-Møller, Merete

    2004-09-09

    We have investigated the protective effect of immunization of a highly susceptible natural host of canine distemper virus (CDV) with DNA plasmids encoding the viral nucleoprotein (N) and hemagglutinin (H). The combined intradermal and intramuscular routes of immunization elicited high virus-neutralizing serum antibody titres in mink (Mustela vison). To mimic natural exposure, we also conducted challenge infection by horizontal transmission from infected contact animals. Other groups received a lethal challenge infection by administration to the mucosae of the respiratory tract and into the muscle. One of the mink vaccinated with N plasmid alone developed severe disease after challenge. In contrast, vaccination with the H plasmid together with the N plasmid conferred solid protection against disease and we were unable to detect CDV infection in PBMCs or in different tissues after challenge. Our findings show that DNA immunization by the combined intradermal and intramuscular routes can confer solid protective immunity against naturally transmitted morbillivirus infection and disease.

  1. Long-term evaluation of mucosal and systemic immunity and protection conferred by different polio booster vaccines.

    Science.gov (United States)

    Xiao, Yuhong; Daniell, Henry

    2017-09-25

    Oral polio vaccine (OPV) and Inactivated Polio Vaccine (IPV) have distinct advantages and limitations. IPV does not provide mucosal immunity and introduction of IPV to mitigate consequences of circulating vaccine-derived polio virus from OPV has very limited effect on transmission and OPV campaigns are essential for interrupting wild polio virus transmission, even in developed countries with a high coverage of IPV and protected sewer systems. The problem is magnified in many countries with limited resources. Requirement of refrigeration for storage and transportation for both IPV and OPV is also a major challenge in developing countries. Therefore, we present here long-term studies on comparison of a plant-based booster vaccine, which is free of virus and cold chain with IPV boosters and provide data on mucosal and systemic immunity and protection conferred by neutralizing antibodies. Mice were primed subcutaneously with IPV and boosted orally with lyophilized plant cells containing 1μg or 25μg polio viral protein 1 (VP1), once a month for three months or a single booster one year after the first prime. Our results show that VP1-IgG1 titers in single or double dose IPV dropped to background levels after one year of immunization. This decrease correlated with >50% reduction in seropositivity in double dose and <10% seropositivity in single dose IPV against serotype 1. Single dose IPV offered no or minimal protection against serotype 1 and 2 but conferred protection against serotype 3. VP1-IgA titers were negligible in IPV single or double dose vaccinated mice. VP1 antigen with two plant-derived adjuvants induced significantly high level and long lasting VP1-IgG1, IgA and neutralizing antibody titers (average 4.3-6.8 log2 titers). Plant boosters with VP1 and plant derived adjuvants maintained the same level titers from 29 to 400days and conferred the same level of protection against all three serotypes throughout the duration of this study. Even during period, when

  2. Second international conference on isotopes. Conference proceedings

    International Nuclear Information System (INIS)

    Hardy, C.J.

    1997-10-01

    The Second International Conference on Isotopes (2ICI) was hosted by the Australian Nuclear Association in Sydney, NSW, Australia. The Theme of the Second Conference: Isotopes for Industry, Health and a Better Environment recognizes that isotopes have been used in these fields successfully for many years and offer prospects for increasing use in the future. The worldwide interest in the use of research reactors and accelerators and in applications of stable and radioactive isotopes, isotopic techniques and radiation in industry, agriculture, medicine, environmental studies and research in general, was considered. Other radiation issues including radiation protection and safety were also addressed. International and national overviews and subject reviews invited from leading experts were included to introduce the program of technical sessions. The invited papers were supported by contributions accepted from participants for oral and poster presentation. A Technical Exhibition was held in association with the Conference. This volume contains the foreword, technical program, the author index and of the papers (1-60) presented at the conference

  3. Second international conference on isotopes. Conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, C J [ed.

    1997-10-01

    The Second International Conference on Isotopes (2ICI) was hosted by the Australian Nuclear Association in Sydney, NSW, Australia. The Theme of the Second Conference: Isotopes for Industry, Health and a Better Environment recognizes that isotopes have been used in these fields successfully for many years and offer prospects for increasing use in the future. The worldwide interest in the use of research reactors and accelerators and in applications of stable and radioactive isotopes, isotopic techniques and radiation in industry, agriculture, medicine, environmental studies and research in general, was considered. Other radiation issues including radiation protection and safety were also addressed. International and national overviews and subject reviews invited from leading experts were included to introduce the program of technical sessions. The invited papers were supported by contributions accepted from participants for oral and poster presentation. A Technical Exhibition was held in association with the Conference. This volume contains the foreword, technical program, the author index and of the papers (1-60) presented at the conference.

  4. The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

    Directory of Open Access Journals (Sweden)

    Xiaoli Chen

    2017-01-01

    Full Text Available Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ is a traditional antimalarial drug and also possesses an anti-inflammatory property. In this study, we investigated whether CQ suppresses NLRP3 inflammasome activation and thereby confers protection against murine endotoxic shock. CQ attenuated NF-κB and MAPK activation and prohibited expression of IL-1β, IL-18, and Nlrp3 in LPS treated murine bone marrow-derived macrophages (BMDMs, demonstrating its inhibitory effect on the priming signal of NLRP3 activation. Then, CQ was shown to inhibit caspase-1 activation and ASC specks formation in BMDMs, which indicates that CQ also suppresses inflammasome assembly, the second signal for NLRP3 inflammasome activation. In a murine endotoxic shock model, CQ effectively improved survival and markedly reduced IL-1β and IL-18 production in serum, peritoneal fluid, and lung tissues. Moreover, CQ reduced protein levels of NLRP3 and caspases-1 p10 in lung homogenates of mice with endotoxic shock, which may possibly explain its anti-inflammatory activity and life protection efficacy in vivo. Overall, our results demonstrate a new role of CQ that facilitates negative regulation on NLRP3 inflammasome, which thereby confers protection against lethal endotoxic shock.

  5. 11th International Space Conference on Protection of Materials and Structures from Space Environment

    CERN Document Server

    2017-01-01

    The proceedings published in this book document and foster the goals of the 11th International Space Conference on “Protection of Materials and Structures from Space Environment” ICPMSE-11 to facilitate exchanges between members of the various engineering and science disciplines involved in the development of space materials. Contributions cover aspects of interaction with space environment of LEO, GEO, Deep Space, Planetary environments, ground-based qualification and in-flight experiments, as well as lessons learned from operational vehicles that are closely interrelated to disciplines of atmospheric sciences, solar-terrestrial interactions and space life sciences.

  6. Individual protections and ergonomics

    International Nuclear Information System (INIS)

    2000-01-01

    The object of this conference was the protective clothing against radioactive contamination. The regulatory frame, the physiological constraints and the human factor are the different aspects studied through the conference with a constant objective, the optimization of radiation protection. (N.C.)

  7. Threats, protests greet conference.

    Science.gov (United States)

    Struck, D

    1994-09-04

    In preparation for the 1994 International Conference on Population and Development, Egypt has deployed 14,000 police to protect participants from threatened violence. The Vatican has joined forces with Muslim fundamentalists to condemn the conference as a vehicle for imposing Western ideals, particularly abortion, on Third world countries. In addition, the opposition is raising the specter of a descent of homosexuals onto Cairo and Muslim fundamentalists have threatened to murder Western representatives. A suit filed by Islamic lawyers, aimed at stopping the conference, failed. Sudan and Saudi Arabia plan to boycott the conference, and it remains uncertain whether Libya will be represented. Conference organizers have not been deterred by the threats and note that the controversy has drawn public attention to the central issues under debate.

  8. Vaccination with Recombinant Microneme Proteins Confers Protection against Experimental Toxoplasmosis in Mice.

    Directory of Open Access Journals (Sweden)

    Camila Figueiredo Pinzan

    Full Text Available Toxoplasmosis, a zoonotic disease caused by Toxoplasma gondii, is an important public health problem and veterinary concern. Although there is no vaccine for human toxoplasmosis, many attempts have been made to develop one. Promising vaccine candidates utilize proteins, or their genes, from microneme organelle of T. gondii that are involved in the initial stages of host cell invasion by the parasite. In the present study, we used different recombinant microneme proteins (TgMIC1, TgMIC4, or TgMIC6 or combinations of these proteins (TgMIC1-4 and TgMIC1-4-6 to evaluate the immune response and protection against experimental toxoplasmosis in C57BL/6 mice. Vaccination with recombinant TgMIC1, TgMIC4, or TgMIC6 alone conferred partial protection, as demonstrated by reduced brain cyst burden and mortality rates after challenge. Immunization with TgMIC1-4 or TgMIC1-4-6 vaccines provided the most effective protection, since 70% and 80% of mice, respectively, survived to the acute phase of infection. In addition, these vaccinated mice, in comparison to non-vaccinated ones, showed reduced parasite burden by 59% and 68%, respectively. The protective effect was related to the cellular and humoral immune responses induced by vaccination and included the release of Th1 cytokines IFN-γ and IL-12, antigen-stimulated spleen cell proliferation, and production of antigen-specific serum antibodies. Our results demonstrate that microneme proteins are potential vaccines against T. gondii, since their inoculation prevents or decreases the deleterious effects of the infection.

  9. Vaccination with Recombinant Microneme Proteins Confers Protection against Experimental Toxoplasmosis in Mice.

    Science.gov (United States)

    Pinzan, Camila Figueiredo; Sardinha-Silva, Aline; Almeida, Fausto; Lai, Livia; Lopes, Carla Duque; Lourenço, Elaine Vicente; Panunto-Castelo, Ademilson; Matthews, Stephen; Roque-Barreira, Maria Cristina

    2015-01-01

    Toxoplasmosis, a zoonotic disease caused by Toxoplasma gondii, is an important public health problem and veterinary concern. Although there is no vaccine for human toxoplasmosis, many attempts have been made to develop one. Promising vaccine candidates utilize proteins, or their genes, from microneme organelle of T. gondii that are involved in the initial stages of host cell invasion by the parasite. In the present study, we used different recombinant microneme proteins (TgMIC1, TgMIC4, or TgMIC6) or combinations of these proteins (TgMIC1-4 and TgMIC1-4-6) to evaluate the immune response and protection against experimental toxoplasmosis in C57BL/6 mice. Vaccination with recombinant TgMIC1, TgMIC4, or TgMIC6 alone conferred partial protection, as demonstrated by reduced brain cyst burden and mortality rates after challenge. Immunization with TgMIC1-4 or TgMIC1-4-6 vaccines provided the most effective protection, since 70% and 80% of mice, respectively, survived to the acute phase of infection. In addition, these vaccinated mice, in comparison to non-vaccinated ones, showed reduced parasite burden by 59% and 68%, respectively. The protective effect was related to the cellular and humoral immune responses induced by vaccination and included the release of Th1 cytokines IFN-γ and IL-12, antigen-stimulated spleen cell proliferation, and production of antigen-specific serum antibodies. Our results demonstrate that microneme proteins are potential vaccines against T. gondii, since their inoculation prevents or decreases the deleterious effects of the infection.

  10. Single shot of 17D vaccine may not confer life-long protection against yellow fever.

    Science.gov (United States)

    Vasconcelos, Pedro Fc

    2018-02-01

    The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus . Until 2013, the World Health Organization (WHO) recommended the administration of a vaccine dose every ten years. A new recommendation of a single vaccine dose to confer life-long protection against YFV infection has since been established. Recent evidence published elsewhere suggests that at least a second dose is needed to fully protect against YF disease. Here, we discuss the feasibility of administering multiple doses, the necessity for a new and modern vaccine, and recommend that the WHO conveys a meeting to discuss YFV vaccination strategies for people living in or travelling to endemic areas.

  11. Cafestol: a multi-faced compound kinetics and metabolic effects of cafestol in mice

    NARCIS (Netherlands)

    Cruchten, van S.T.J.

    2010-01-01

    Cafestol and kahweol are two diterpenes present in unfiltered coffees such as Scandinavian-style boiled coffee, French press coffee and espresso. The health effects of cafestol and kahweol can be positive but also potentially harmful. On the one hand cafestol shows chemo-preventive properties, which

  12. 75 FR 82387 - Next Generation Risk Assessment Public Dialogue Conference

    Science.gov (United States)

    2010-12-30

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Public Dialogue Conference... methods with the National Institutes of Environmental Health Sciences' National Toxicology Program, Center...

  13. Chernobyl - 10 years on. Proceedings of a conference organised by the Radiological Protection Institute of Ireland

    International Nuclear Information System (INIS)

    1996-10-01

    The consequences of the Chernobyl nuclear accident from an Irish perspective was the focus of a conference organised by the Radiological Protection Institute of Ireland to mark the tenth anniversary of the accident. The health consequences of Chernobyl were discussed along with presentations on such issues as the hazards to the Irish population from Sellafield; the radiation hazard posed by radon gas; radiation hazards in medicine, industry and education, and Ireland's National Emergency Plan for Nuclear Accidents

  14. Chernobyl - 10 years on. Proceedings of a conference organised by the Radiological Protection Institute of Ireland

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The consequences of the Chernobyl nuclear accident from an Irish perspective was the focus of a conference organised by the Radiological Protection Institute of Ireland to mark the tenth anniversary of the accident. The health consequences of Chernobyl were discussed along with presentations on such issues as the hazards to the Irish population from Sellafield; the radiation hazard posed by radon gas; radiation hazards in medicine, industry and education, and Ireland`s National Emergency Plan for Nuclear Accidents.

  15. A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis.

    Directory of Open Access Journals (Sweden)

    Bappaditya Dey

    Full Text Available BACKGROUND: In spite of a consistent protection against tuberculosis (TB in children, Mycobacterium bovis Bacille Calmette-Guerin (BCG fails to provide adequate protection against the disease in adults as well as against reactivation of latent infections or exogenous reinfections. It has been speculated that failure to generate adequate memory T cell response, elicitation of inadequate immune response against latency-associated antigens and inability to impart long-term immunity against M. tuberculosis infections are some of the key factors responsible for the limited efficiency of BCG in controlling TB. METHODS/PRINCIPAL FINDINGS: In this study, we evaluated the ability of a DNA vaccine expressing α-crystallin--a key latency antigen of M. tuberculosis to boost the BCG induced immunity. 'BCG prime-DNA boost' regimen (B/D confers robust protection in guinea pigs along with a reduced pathology in comparison to BCG vaccination (1.37 log(10 and 1.96 log(10 fewer bacilli in lungs and spleen, respectively; p<0.01. In addition, B/D regimen also confers enhanced protection in mice. Further, we show that B/D immunization in mice results in a heightened frequency of PPD and antigen specific multi-functional CD4 T cells (3(+ simultaneously producing interferon (IFNγ, tumor necrosis factor (TNFα and interleukin (IL2. CONCLUSIONS/SIGNIFICANCE: These results clearly indicate the superiority of α-crystallin based B/D regimen over BCG. Our study, also demonstrates that protection against TB is predictable by an increased frequency of 3(+ Th1 cells with superior effector functions. We anticipate that this study would significantly contribute towards the development of superior booster vaccines for BCG vaccinated individuals. In addition, this regimen can also be expected to reduce the risk of developing active TB due to reactivation of latent infection.

  16. Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.

    Science.gov (United States)

    Joseph, S K; Ramaswamy, K

    2013-07-18

    The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis

    Science.gov (United States)

    Joseph, SK; Ramaswamy, K

    2013-01-01

    The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and Protein or Protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-Protein) and 48% (BmHAT Protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. PMID:23735679

  18. Second international conference on isotopes. Conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, C J [ed.

    1997-10-01

    The Second International Conference on Isotopes (2ICI) was hosted by the Australian Nuclear Association in Sydney, NSW, Australia. The Theme of the Second Conference: Isotopes for Industry, Health and a Better Environment recognizes that isotopes have been used in these fields successfully for many years and offer prospects for increasing use in the future. The worldwide interest in the use of research reactors and accelerators and in applications of stable and radioactive isotopes, isotopic techniques and radiation in industry, agriculture, medicine, environmental studies and research in general, was considered. Other radiation issues including radiation protection and safety were also addressed. International and national overviews and subject reviews invited from leading experts were included to introduce the program of technical sessions. The invited papers were supported by contributions accepted from participants for oral and poster presentation. A Technical Exhibition was held in association with the Conference. This volume contains the full text or extended abstracts of papers number 61- to number 114

  19. The 26. CLI national conference. Conference proceedings

    International Nuclear Information System (INIS)

    Chevet, Pierre-Franck; Niel, Jean-Christophe; Legrand, Henri; Dumont, Jean-Jacques; Lachaume, Jean-Luc; Delalonde, Jean-Claude; Sene, Monique; Le Deaut, Jean Yves; Charles, Thierry; Sasseigne, Philippe; Fournier, Nicolas; Murith, Christophe; Rivasi, Michele; Perissat, Frederic; KESSLER, Emmanuel

    2014-12-01

    This document gathers contributions presented during a conference held in December 2014. After introduction speeches and a focus of some updates by ANCCLI and ASN representatives, this conference comprised two round tables. The first one addressed the continuation of nuclear reactor operation after their fourth safety re-examination, with contributions by representatives of the ASN, of the ANCCLI, of the IRSN, and of EDF. The second one addressed the issue of a European harmonisation regarding actions of protection of populations in case of a nuclear accident, with interventions of representatives of a CLI, of the ASN, of the Swiss federal office for public health, of an NGO (Nuclear Transparency Watch), and of a departmental prefect

  20. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

    DEFF Research Database (Denmark)

    Gudmundsson, Julius; Sulem, Patrick; Steinthorsdottir, Valgerdur

    2007-01-01

    attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against...... 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population......We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome...

  1. 77 FR 4808 - Conference on Air Quality Modeling

    Science.gov (United States)

    2012-01-31

    ... Modeling AGENCY: U.S. Environmental Protection Agency (EPA). ACTION: Notice of conference. SUMMARY: The EPA will be hosting the Tenth Conference on Air Quality Modeling on March 13-15, 2012. Section 320 of the... First, Second, and Third Conferences on Air Quality Modeling as required by CAA Section 320 to help...

  2. International conference in Stockholm to address protection of nuclear material and radioactive sources from illicit trafficking

    International Nuclear Information System (INIS)

    2001-01-01

    The Conference will look at approaches for enhancing security of material in general as well as protecting facilities against terrorism and sabotage. More specifically it will address measures for interception and response to illicit trafficking and discuss the practices and measures currently being used to minimize the possibilities of the unauthorized removal and movement of nuclear materials and critical equipment. It will also consider the importance of closer co-operation with law enforcement authorities and intelligence agencies and the necessity of applying new technologies to this effort

  3. Physical protection of nuclear materials: Experience in regulation, implementation and operations. Proceedings of a conference

    International Nuclear Information System (INIS)

    1998-01-01

    The conference was held at IAEA Headquarters in Vienna from 10 to 14 November 1997. It was attended by 162 registered participants from 42 countries and eight international organizations. The 58 papers presented dealt with the experience of regulators, designers and facility operators, including response forces, in meeting the demands and requirements in this changing area of physical protection of nuclear materials and facilities. Individual abstracts were prepared for each of the papers. Topics covered include contemporary and emerging issues, experience in regulation, implementation at facilities, program assessment and cooperation, hardware and software, illicit trafficking in nuclear materials, and transportation

  4. II International Conference: Radiation Protection Training. Future Strategies. Ciemat, 17-19 September, 2003. Book of Papers and Proceedings

    International Nuclear Information System (INIS)

    2003-01-01

    Safety in the use of ionising radiation and protection against potential risks due to exposure to radiation sources are not static concepts, rather their evolution runs parallel with an increased knowledge of the technologies and basic concepts employed. Education and training, which are inherently tied to with research, are the means to disseminate the advances made to the scientists and professionals working with ionising radiation. At present, Radiation Protection (RP) training is considered to be the best means to promote a safety culture and to improve the competence of exposed workers. Indeed, progress in both RP teaching and training, which form part of this transfer of technology and specialized knowledge, are fields that are in continuous motion. The first conference on Radiation Protection training was celebrated in Saclay (France) under the slogan Radiation Protection: What are the Future Training needs?. It can be considered as the first such meeting dedicated to the community of professionals, from a wide range of scientific and technological backgrounds, related in some way to Radiation Protection training. (Author)

  5. Radiation protection in medicine

    International Nuclear Information System (INIS)

    Vano, E.; Holmberg, O.; Perez, M. R.; Ortiz, P.

    2016-01-01

    Diagnostic, interventional and therapeutic used of ionizing radiation are beneficial for hundreds of millions of people each year by improving health care and saving lives. In March 2001, the first International Conference on the Radiological Protection of Patients was held in Malaga, Spain, which led to an international action plan for the radiation protection of patients. Ten years after establishing the international action plan, the International Conference on Radiation Protection in Medicine: Setting the Scene for the Next Decade was held in Bonn, Germany, in December 2012. the main outcome of this conference was the so called Bonn Call for Action that identifies then priority actions to enhance radiation protection in medicine for the next decade. The IAEA and WHO are currently working in close cooperation to foster and support the implementation of these ten priority actions in Member States, but their implementation requires collaboration of national governments, international agencies, researchers, educators, institutions and professional associations. (Author)

  6. Radiation protection in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Vano, E.; Holmberg, O.; Perez, M. R.; Ortiz, P.

    2016-08-01

    Diagnostic, interventional and therapeutic used of ionizing radiation are beneficial for hundreds of millions of people each year by improving health care and saving lives. In March 2001, the first International Conference on the Radiological Protection of Patients was held in Malaga, Spain, which led to an international action plan for the radiation protection of patients. Ten years after establishing the international action plan, the International Conference on Radiation Protection in Medicine: Setting the Scene for the Next Decade was held in Bonn, Germany, in December 2012. the main outcome of this conference was the so called Bonn Call for Action that identifies then priority actions to enhance radiation protection in medicine for the next decade. The IAEA and WHO are currently working in close cooperation to foster and support the implementation of these ten priority actions in Member States, but their implementation requires collaboration of national governments, international agencies, researchers, educators, institutions and professional associations. (Author)

  7. Proceedings of the 4. International Conference on Education and Training in Radiological Protection - ETRAP 2009 Transactions

    International Nuclear Information System (INIS)

    2009-01-01

    Education and training are the two basic pillars of any policy regarding safety in the workplace. Practitioners who work with radiation sources will have a wide range of responsibilities and objectives depending on the radiation practice, but all will have a triple common need: a basic education as well as specific training providing the required level of understanding of artificial and natural radiation and its management; standards for the recognition of skills and experience; an opportunity to refresh, update and test acquired knowledge and competence on a regular basis. International meetings, publications and recommendations covering safety culture in the field of radiological protection increasingly stress the need for education and training. In addition, compliance with the requirements of specific European directives and the international basic safety standards is crucial in a world of dynamic markets and increasing workers mobility, and common approaches to training facilitate the understanding of these requirements. The conference intends to address the largest potential audience, covering policy makers, the medical sector, industrial radiographers, NORM experts, the engineering sector, the non-nuclear industry, social sciences researchers, safety experts, radiation protection experts, radiation protection officers, medical physics experts, regulators and authorities. Furthermore, it aims to reinforce the contacts between various organisations, individuals and networks dealing with education and training policies in radiological protection. Special attention will also be paid to attracting and inviting young professionals to ensure knowledge transfer and to help build the future of radiological protection. (authors)

  8. 10th meeting of the International Conference on Protection of Materials and Structures from Space Environment

    CERN Document Server

    Tagawa, Masahito; Kimoto, Yugo; Protection of Materials and Structures From the Space Environment

    2013-01-01

    The goals of the 10th International Space Conference on “Protection of Materials and Structures from Space Environment” ICPMSE-10J, since its inception in 1992, have been to facilitate exchanges between members of the various engineering and science disciplines involved in the development of space materials, including aspects of LEO, GEO and Deep Space environments, ground-based qualification, and in-flight experiments and lessons learned from operational vehicles that are closely interrelated to disciplines of the atmospheric sciences, solar-terrestrial interactions and space life sciences. The knowledge of environmental conditions on and around the Moon, Mars, Venus and the low Earth orbit as well as other possible candidates for landing such as asteroids have become an important issue, and protecting both hardware and human life from the effects of space environments has taken on a new meaning in light of the increased interest in space travel and colonization of other planets.  And while many materia...

  9. BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE.

    Science.gov (United States)

    Abdel-Ghany, Rasha; Rabia, Ibrahim; El-Ahwany, Eman; Saber, Sameh; Gamal, Rasha; Nagy, Faten; Mahmoud, Olaa; Hamad, Rabab Salem; Barakat, Walled

    2015-12-01

    Schistosomiasis is a chronic disease with considerable social impact. Despite the availability of affordable chemotherapy, drug treatment has not significantly reduced the overall number of disease cases. Among other mechanisms, the parasite produces PGE2 and PGD2 to evade host immune defenses. To investigate the role of PGE2 and PGD2 in schistosomiasis, we evaluated the effects of L-161,982, Ah6809 (PGE2 receptor antagonists alone of combined with each other) and MK-0524 (PGD2 receptor antagonist) during prepatent Schistosoma mansoni infection. Drugs were administered intraperitoneally an hour before and 24 hours after infection of C57BL/6 mice with 100 Schistosoma mansoni cercariae. L-161,982, Ah6809, their combination and MK-0524 caused partial protection against pre-patent S. mansoni infection which was mediated by biasing the immune response towards Th1 phenotype. These results showed that blockade of PGE2 and PGD2 receptors confers partial protection against pre-patent S. mansoni infection in mice and that they may be useful as adjunctive therapy to current anti-schistosomal drugs or vaccines.

  10. A safe vaccine (DV-STM-07 against Salmonella infection prevents abortion and confers protective immunity to the pregnant and new born mice.

    Directory of Open Access Journals (Sweden)

    Vidya Devi Negi

    Full Text Available Pregnancy is a transient immuno-compromised condition which has evolved to avoid the immune rejection of the fetus by the maternal immune system. The altered immune response of the pregnant female leads to increased susceptibility to invading pathogens, resulting in abortion and congenital defects of the fetus and a subnormal response to vaccination. Active vaccination during pregnancy may lead to abortion induced by heightened cell mediated immune response. In this study, we have administered the highly attenuated vaccine strain DeltapmrG-HM-D (DV-STM-07 in female mice before the onset of pregnancy and followed the immune reaction against challenge with virulent S. Typhimurium in pregnant mice. Here we demonstrate that DV-STM-07 vaccine gives protection against Salmonella in pregnant mice and also prevents Salmonella induced abortion. This protection is conferred by directing the immune response towards Th2 activation and Th1 suppression. The low Th1 response prevents abortion. The use of live attenuated vaccine just before pregnancy carries the risk of transmission to the fetus. We have shown that this vaccine is safe as the vaccine strain is quickly eliminated from the mother and is not transmitted to the fetus. This vaccine also confers immunity to the new born mice of vaccinated mothers. Since there is no evidence of the vaccine candidate reaching the new born mice, we hypothesize that it may be due to trans-colostral transfer of protective anti-Salmonella antibodies. These results suggest that our vaccine DV-STM-07 can be very useful in preventing abortion in the pregnant individuals and confer immunity to the new born. Since there are no such vaccine candidates which can be given to the new born and to the pregnant women, this vaccine holds a very bright future to combat Salmonella induced pregnancy loss.

  11. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies.

    Science.gov (United States)

    Steuerman, Rachel; Shevah, Orit; Laron, Zvi

    2011-04-01

    To investigate whether congenital IGF1 deficiency confers protection against development of malignancies, by comparing the prevalence of malignancies in patients with congenital (secondary) deficiency of IGF1 with the prevalence of cancer in their family members. Only patients with an ascertained diagnosis of either Laron syndrome (LS), congenital IGHD, congenital multiple pituitary hormone deficiency (cMPHD) including GH or GHRHR defect were included in this study. In addition to our own patients, we performed a worldwide survey and collected data on a total of 538 patients, 752 of their first-degree family members, of which 274 were siblings and 131 were further family members. We found that none of the 230 LS patients developed cancer and that only 1 out of 116 patients with congenital IGHD, also suffering from xeroderma pigmentosum, had a malignancy. Out of 79 patients with GHRHR defects and out of 113 patients with congenital MPHD, we found three patients with cancer in each group. Among the first-degree family members (most heterozygotes) of LS, IGHD and MPHD, we found 30 cases of cancer and 1 suspected. In addition, 31 malignancies were reported among 131 further relatives. Our findings bear heavily on the relationship between GH/IGF1 and cancer. Homozygous patients with congenital IGF1 deficiency and insensitivity to GH such as LS seem protected from future cancer development, even if treated by IGF1. Patients with congenital IGHD also seem protected.

  12. Patients radiation protection in medical imaging. Conference proceedings; Radioprotection des patients en imagerie medicale. Recueil des presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-12-15

    This document brings together the available presentations given at the conference organised by the French society of radiation protection about patients radiation protection in medical imaging. Twelve presentations (slides) are compiled in this document and deal with: 1 - Medical exposure of the French population: methodology and results (Bernard Aubert, IRSN); 2 - What indicators for the medical exposure? (Cecile Etard, IRSN); 3 - Guidebook of correct usage of medical imaging examination (Philippe Grenier, Pitie-Salpetriere hospital); 4 - Radiation protection optimization in pediatric imaging (Hubert Ducou-Le-Pointe, Aurelien Bouette (Armand-Trousseau children hospital); 5 - Children's exposure to image scanners: epidemiological survey (Marie-Odile Bernier, IRSN); 6 - Management of patient's irradiation: from image quality to good practice (Thierry Solaire, General Electric); 7 - Dose optimization in radiology (Cecile Salvat (Lariboisiere hospital); 8 - Cancer detection in the breast cancer planned screening program - 2004-2009 era (Agnes Rogel, InVS); 9 - Mammographic exposures - radiobiological effects - radio-induced DNA damages (Catherine Colin, Lyon Sud hospital); 10 - Breast cancer screening program - importance of non-irradiating techniques (Anne Tardivon, Institut Curie); 11 - Radiation protection justification for the medical imaging of patients over the age of 50 (Michel Bourguignon, ASN); 12 - Search for a molecular imprint for the discrimination between radio-induced and sporadic tumors (Sylvie Chevillard, CEA)

  13. Comparison of potential protection conferred by three immunization strategies (protein/protein, DNA/DNA, and DNA/protein) against Brucella infection using Omp2b in BALB/c Mice.

    Science.gov (United States)

    Golshani, Maryam; Rafati, Sima; Nejati-Moheimani, Mehdi; Ghasemian, Melina; Bouzari, Saeid

    2016-12-25

    In the present study, immunogenicity and protective efficacy of the Brucella outer membrane protein 2b (Omp2b) was evaluated in BALB/c mice using Protein/Protein, DNA/DNA and DNA/Protein vaccine strategies. Immunization of mice with three vaccine regimens elicited a strong specific IgG response (higher IgG2a titers over IgG1 titers) and provided Th1-oriented immune response. Vaccination of BALB/c mice with the DNA/Pro regimen induced higher levels of IFN-γ/IL-2 and conferred more protection levels against B. melitenisis and B. abortus challenge than did the protein or DNA alone. In conclusion, Omp2b is able to stimulate specific immune responses and to confer cross protection against B. melitensis and B. abortus infection. Therefore, it could be introduced as a new potential candidate for the development of a subunit vaccine against Brucella infection. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. XXXVI. Days of Radiation Protection. Book of Abstracts

    International Nuclear Information System (INIS)

    2014-11-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 93 abstracts are published. The Conference consists of following sections: (I) General aspects and new trends of radiation protection); (II) Radiation protection in medicine; (III): Dosimetry and metrology of external and internal radiation exposure; (IV) Regulation of radiation exposure to natural sources and control of radon exposure; (V) Radiation protection in nuclear power plants, their decommissioning and waste management; (VI) Application of radiation protection standards in the emergency management; (VII) Biological effects of ionizing radiation and risk estimation; (VIII) Education and training in radiation protection in the light of new recommendations of EU, ICRP and IAEA.

  15. Affinity Maturation of an Anti-V Antigen IgG Expressed In Situ Via Adenovirus Gene Delivery Confers Enhanced Protection Against Yersinia pestis Challenge

    Science.gov (United States)

    Van Blarcom, Thomas J.; Sofer-Podesta, Carolina; Ang, John; Boyer, Julie L.; Crystal, Ronald G.; Georgiou, George

    2013-01-01

    Genetic transfer of neutralizing antibodies has been shown to confer strong and persistent protection against bacterial and viral infectious agents. While it is well established that for many exogenous neutralizing antibodies increased antigen affinity correlates with protection, the effect of antigen affinity on antibodies produced in situ following adenoviral gene transfer has not been examined. The mouse IgG2b monoclonal antibody 2C12.4 recognizes the Yersinia pestis Type III secretion apparatus protein LcrV (V antigen) and confers protection in mice when administered as an IgG intraperitoneally or, following genetic immunization with engineered, replication-defective serotype 5 human adenovirus (Ad) 1. 2C12.4 was expressed as a scFv fragment in E. coli and was shown to display a KD=3.5 nM by surface plasmon resonance (SPR) analysis. The 2C12.4 scFv was subjected to random mutagenesis and variants with increased affinity were isolated by flow cytometry using the Anchored Periplasmic Expression (APEx) bacterial display system. After a single round of mutagenesis, variants displaying up to 35-fold lower KD values (H8, KD=100 pM) were isolated. The variable domains of the H8 scFv were used to replace those of the parental 2C12.4 IgG encoded in the Ad vector, AdαV giving rise to AdαV.H8. The two adenoviral vectors resulted in similar titers of anti-V antigen antibodies 3 days post-immunization with 109, 1010 or 1011 particle units. Following intranasal challenge with 363 LD50Y. pestis CO92, 54% of the mice immunized with 1010 pu of AdαV.H8 survived at the 14 day end point compared to only 15% survivors for the group immunized with AdαV expressing the lower affinity 2C12.4 (Pgenetic transfer may confer increased protection not only for Y. pestis challenge but possibly for other pathogens. PMID:20393511

  16. Summary of the eighth conference on protection against radon at home and at work and the 13. workshop on the geological aspects of radon risk mapping

    International Nuclear Information System (INIS)

    Navratilova Rovenska, K.; Thinova, L.; Neznal, M.

    2017-01-01

    This paper provides summary of the 8. Conference on Protection against Radon at Home and at Work and 13. Workshop on the Geological Aspects of Radon Risk Mapping held in September 2016 in Prague, Czech Republic. (authors)

  17. Proceedings of East Asia and Pacific area corrosion conference and expo: conference souvenir

    International Nuclear Information System (INIS)

    2011-01-01

    The 19th annual conference being hosted by NACE International Gateway India Section (NIGIS) CORCON 2011 will feature technical symposia, interactive technical sessions and an expo. By promoting awareness and knowledge related to corrosion and its control through its educational programs and annual conferences, NIGIS reflects the mission and objectives of NACE International in India. The annual conference branded as 'CORCON', has emerged as the premier forum in India for Indian and overseas professionals wishing to interact on matters related to corrosion and its prevention. The technical symposia comprise a wide array of corrosion - related topics such as: Paints Coating and Lining, Materials and Composites, Inhibitors, MIC, Cathodic Protection, Failure Analysis, Inspection and Testing and covers sectors such as RCC and Infrastructure and Electric Power and Utilities. Papers relevant to INIS are indexed separately

  18. Toll-like Receptor 4 Signaling Confers Cardiac Protection Against Ischemic Injury via Inducible Nitric Oxide Synthase- and Soluble Guanylate Cyclase-dependent Mechanisms

    Science.gov (United States)

    Wang, E; Feng, Yan; Zhang, Ming; Zou, Lin; Li, Yan; Buys, Emmanuel S.; Huang, Peigen; Brouckaert, Peter; Chao, Wei

    2011-01-01

    Background Prior administration of a small dose of lipopolysaccharide confers a cardiac protection against ischemia-reperfusion injury. However, the signaling mechanisms that control the protection are incompletely understood. We tested the hypothesis that TLR4 mediates the ability of lipopolysaccharide to protect against cardiac ischemia-reperfusion injury through distinct intracellular pathways involving myeloid differentiation factor 88 (MyD88), TIR-domain-containing adaptor protein inducing interferon-β–mediated transcription-factor (Trif), inducible nitric-oxide synthase (iNOS), and soluble guanylate cyclase (sGC). Methods Wild-type mice and the genetically modified mice, i.e., TLR4-deficient (TLR4-def), TLR2 knockout (TLR2−/−), MyD88−/−, Trif−/−, iNOS−/−, and sGCα1−/−, were treated with normal saline or 0.1 mg/kg of lipopolysaccharide, intraperitoneally. Twenty-four hours later, isolated hearts were perfused in a Langendorff apparatus and subsequently subjected to 30 min of global ischemia and reperfusion for up to 60 min. Left ventricular function and myocardial infarction sizes were examined. Results Compared to saline-treated mice, lipopolysaccharide-treated mice had markedly improved left ventricular developed pressure and dP/dtmax (P < 0.01) and reduced MI sizes (37.2 ± 3.4% vs. 19.8 ± 4.9%, P < 0.01) after ischemia-reperfusion. The cardiac protective effect of lipopolysaccharide was abolished in the TLR4-def and MyD88−/− mice, but remained intact in TLR2−/− or Trif−/− mice. iNOS−/− mice or wild-type mice treated with the iNOS inhibitor 1400W failed to respond to the TLR4-induced nitric oxide production and were not protected by the lipopolysaccharide preconditioning. While sGC 1−/− mice had robust nitric oxide production in response to lipopolysaccharide, they were not protected by the TLR4-elicited cardiac protection. Conclusions TLR4 activation confers a potent cardiac protection against ischemia

  19. Proceedings of the International Conference on Modern Radiotherapy. Advances and Challenges in Radiation Protection of Patients

    International Nuclear Information System (INIS)

    2009-12-01

    The use of ionizing radiation in medicine has led to major improvements in the diagnosis and treatment of human diseases. While bringing new benefits for cancer treatment, modern radiotherapy also poses new challenges in terms of radiation protection of patients. Prevention of radiotherapy incidents and accidents is a major issue in this area. In December 2009, the French Nuclear Safety Authority (ASN) organised the 1. international conference on radiation protection of patients in radiotherapy. The major objective of the conference was to provide a platform for exchanging experience, and reviewing the actions implemented to improve the radiation safety in radiotherapy both at national and international level. The expected result was: - to reach a consensus about the necessity to strengthen existing international actions for prevention of incidents and accidents, - to set up an international cooperation to improve management for overexposed patients, - to outline a strategy for strengthening regulation, - to contribute to the elaboration of an international scale to rate patient related events for communication and reporting purpose. 360 delegates from 50 countries across the world participated at the 3-day conference. 41 presentations were made and 67 posters were displayed. The conference brought together a broad spectrum of expertise: scientists, health professionals, medical devices manufacturers, risk management specialists, radiation protection experts, representatives from Radiation Protection and Health Authorities as well as patient's associations. The programme covered both scientific and medical issues, such as patient sensitivity to ionising radiation and the treatment of complications. It also provided scope to discuss the benefits and risks of modern radiotherapy and to explore treatment safety issues from various perspectives, including human resources, expertise, education and training along with control and prevention strategies. The conference

  20. Proceedings of the Second All African IRPA Regional Radiation Protection Congress

    International Nuclear Information System (INIS)

    2008-01-01

    The publication has been set up as proceedings of the radiation protection conference. the conference consistes of Radiation Protection Infrastructure and training; the Environmental; Occupational; Medical; Transport and Waste Safety; Emergency and Security; Non Ionizing Radiation and Miscellaneous. This conference consistes of 310p., figs., tabs., refrs

  1. Protecting intellectual property in space; Proceedings of the Aerospace Computer Security Conference, McLean, VA, March 20, 1985

    Science.gov (United States)

    1985-01-01

    The primary purpose of the Aerospace Computer Security Conference was to bring together people and organizations which have a common interest in protecting intellectual property generated in space. Operational concerns are discussed, taking into account security implications of the space station information system, Space Shuttle security policies and programs, potential uses of probabilistic risk assessment techniques for space station development, key considerations in contingency planning for secure space flight ground control centers, a systematic method for evaluating security requirements compliance, and security engineering of secure ground stations. Subjects related to security technologies are also explored, giving attention to processing requirements of secure C3/I and battle management systems and the development of the Gemini trusted multiple microcomputer base, the Restricted Access Processor system as a security guard designed to protect classified information, and observations on local area network security.

  2. XXXIX Days of Radiation Protection. Proceedings of Abstracts

    International Nuclear Information System (INIS)

    2018-01-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 91 abstracts are published. The Conference consists of following sections: (I) Radiation protection, consequences of implementation of the EU2013 / 59 directive in the Czech Republic and the Slovak Republic); (II) Radiation protection in the application of ionizing radiation in medicine; (III) Dosimetry and metrology of external and internal irradiation; (IV) Natural sources of ionizing radiation, national radon programs; (V) Nuclear energy, the concept of decommissioning of nuclear power plants in terms of radiation protection; (VI) Use of standards of radiation protection in emergency management; (VII) Biological effects of radiation and estimation of irradiation risk.

  3. SAPONIFICAÇÃO ASSISTIDA POR MICRO-ONDAS NA EXTRAÇÃO DE DITERPENOS EM CAFÉ ARÁBICA TORRADO

    Directory of Open Access Journals (Sweden)

    Mirelli Bianchin

    Full Text Available The extraction of kahweol and cafestol involves saponification reaction. This step is important for the efficiency of the extraction as the diterpenes are susceptible to structural changes during hydrolysis. The microwave-assisted saponification has been successfully used in different matrices, but there is no previous report of the use of this technique in the saponification of diterpenes. Therefore, the effect of microwave-assisted saponification on the extraction of kahweol and cafestol in roasted coffee was evaluated. A 32 factorial experimental design was used in order to evaluate the effect of temperature (70, 80, and 90 ºC and reaction time (4, 8, and 12 min. The quantification of diterpenes was performed by high-performance liquid chromatography and the results were compared to with those obtained by a method, which uses thermostatic bath for saponification. Temperature and time had a significant effect (p < 0.05 on diterpenes levels. For simultaneous saponification of kahweol and cafestol, the optimal reaction conditions were 80 ºC / 12 min. The use of microwave-assisted procedure lead to lower yields of kahweol (24% and cafestol (35% compared to reference method. However a significant reduction of reaction time (80% was achieved, and the procedure also has the advantage of controlled process conditions and the possibility of extended scale.

  4. Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid.

    Science.gov (United States)

    Leduc, Isabelle; Fusco, William G; Choudhary, Neelima; Routh, Patty A; Cholon, Deborah M; Hobbs, Marcia M; Almond, Glen W; Orndorff, Paul E; Elkins, Christopher

    2011-08-01

    Haemophilus ducreyi, the etiologic agent of chancroid, has an obligate requirement for heme. Heme is acquired by H. ducreyi from its human host via TonB-dependent transporters expressed at its bacterial surface. Of 3 TonB-dependent transporters encoded in the genome of H. ducreyi, only the hemoglobin receptor, HgbA, is required to establish infection during the early stages of the experimental human model of chancroid. Active immunization with a native preparation of HgbA (nHgbA) confers complete protection in the experimental swine model of chancroid, using either Freund's or monophosphoryl lipid A as adjuvants. To determine if transfer of anti-nHgbA serum is sufficient to confer protection, a passive immunization experiment using pooled nHgbA antiserum was conducted in the experimental swine model of chancroid. Pigs receiving this pooled nHgbA antiserum were protected from a homologous, but not a heterologous, challenge. Passively transferred polyclonal antibodies elicited to nHgbA bound the surface of H. ducreyi and partially blocked hemoglobin binding by nHgbA, but were not bactericidal. Taken together, these data suggest that the humoral immune response to the HgbA vaccine is protective against an H. ducreyi infection, possibly by preventing acquisition of the essential nutrient heme.

  5. Passive Immunization with a Polyclonal Antiserum to the Hemoglobin Receptor of Haemophilus ducreyi Confers Protection against a Homologous Challenge in the Experimental Swine Model of Chancroid▿

    Science.gov (United States)

    Leduc, Isabelle; Fusco, William G.; Choudhary, Neelima; Routh, Patty A.; Cholon, Deborah M.; Hobbs, Marcia M.; Almond, Glen W.; Orndorff, Paul E.; Elkins, Christopher

    2011-01-01

    Haemophilus ducreyi, the etiologic agent of chancroid, has an obligate requirement for heme. Heme is acquired by H. ducreyi from its human host via TonB-dependent transporters expressed at its bacterial surface. Of 3 TonB-dependent transporters encoded in the genome of H. ducreyi, only the hemoglobin receptor, HgbA, is required to establish infection during the early stages of the experimental human model of chancroid. Active immunization with a native preparation of HgbA (nHgbA) confers complete protection in the experimental swine model of chancroid, using either Freund's or monophosphoryl lipid A as adjuvants. To determine if transfer of anti-nHgbA serum is sufficient to confer protection, a passive immunization experiment using pooled nHgbA antiserum was conducted in the experimental swine model of chancroid. Pigs receiving this pooled nHgbA antiserum were protected from a homologous, but not a heterologous, challenge. Passively transferred polyclonal antibodies elicited to nHgbA bound the surface of H. ducreyi and partially blocked hemoglobin binding by nHgbA, but were not bactericidal. Taken together, these data suggest that the humoral immune response to the HgbA vaccine is protective against an H. ducreyi infection, possibly by preventing acquisition of the essential nutrient heme. PMID:21646451

  6. 28. conference of the Nuclear Societies in Israel. Program and papers

    International Nuclear Information System (INIS)

    2016-01-01

    The File contains the presentations of the 28 annual conference of the nuclear societies in Israel. The subjects of the Conference are aspects of nuclear energy and nuclear technology, applications of radioisotopes and radiation, radiation measurements, issues in radiation protection and radiation in medicine. During the conference awards will be given for outstanding student works

  7. 33. Days of Radiation Protection. Presentations

    International Nuclear Information System (INIS)

    2011-11-01

    The publication has been set up as presentations of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on the current problems in radiation protection and radioecology. On the web-page totally 103 presentations or posters are published. The Conference consists of the following sections: (I) Effects of ionizing radiation (radiology, health effects, risk factors); (II) General aspects of radiation protection (recommendations and legislative in radiation protection); (III): Dosimetry and metrology of ionizing radiation (metrology, instrumentation, use of computational methods); (IV) Radiation protection in nuclear power industry (working environment in the nuclear industry, the impact on the environment, nuclear power shutdown management); (V) Emergency management (emergencies, accidents, waste); (VI) Radiation load and protection in diagnostics, nuclear medicine and radiation oncology (burden on patients, staff, size of population exposure from medical sources of ionizing radiation, security, and quality control, optimization); (VII) Natural sources of radiation in workplaces and the environment (radon and other radionuclides, the risk estimation, optimization); (VIII) Education (new trends in education of radiation experts, medical physicists and stake-holders).

  8. Evolution of the system of radiological protection

    International Nuclear Information System (INIS)

    2004-01-01

    The development of new radiological protection recommendations by the International Commission on Radiological Protection (ICRP) continues to be a strategically important undertaking, both nationally and internationally. With the growing recognition of the importance of stakeholder aspects in radiological protection decision making, regional and cultural aspects have also emerged as having potentially significant influence on how protection of the public, workers and the environment are viewed. Differing cultural aspects should therefore be considered by the ICRP in its development of new recommendations. Based on this assumption, the NEA organised the Asian Regional Conference on the Evolution of the System of Radiological Protection to express and explore views from the Far East. Held in Tokyo on 24-25 October 2002, the conference included presentations by the ICRP Chair as well as by radiological protection experts from Japan, the Republic of Korea, China and Australia. The distinct views and needs of these countries were discussed in the context of their regional and cultural heritages. These views, along with a summary of the conference results, are presented in these proceedings. (author)

  9. The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats

    International Nuclear Information System (INIS)

    Camats, N.; Garcia, F.; Parrilla, J.J.; Calaf, J.; Martin-Mateo, M.; Caldes, M. Garcia

    2009-01-01

    There is a controversy regarding the effects of the analogues of the gonadotrophin-releasing hormone (GnRH) in radiotherapy. This has led us to study the possible radio-protection of the ovarian function of a GnRH agonist analogue (GnRHa), triptorelin, in adult, female rats (Rattus norvegicus sp.). The effects of the X-irradiation on the oocytes of ovarian primordial follicles, with and without GnRHa treatment, were compared, directly in the female rats (F 0 ) with reproductive parameters, and in the somatic cells of the resulting foetuses (F 1 ) with cytogenetical parameters. In order to do this, the ovaries and uteri from 82 females were extracted for the reproductive analysis and 236 foetuses were obtained for cytogenetical analysis. The cytogenetical study was based on the data from 22,151 metaphases analysed. The cytogenetical parameters analysed to assess the existence of chromosomal instability were the number of aberrant metaphases (2234) and the number (2854) and type of structural chromosomal aberrations, including gaps and breaks. Concerning the reproductive analysis of the ovaries and the uteri, the parameters analysed were the number of corpora lutea, implantations, implantation losses and foetuses. Triptorelin confers radio-protection of the ovaries in front of chromosomal instability, which is different, with respect to the single and fractioned dose. The cytogenetical analysis shows a general decrease in most of the parameters of the triptorelin-treated groups, with respect to their controls, and some of these differences were considered to be statistically significant. The reproductive analysis indicates that there is also radio-protection by the agonist, although minor to the cytogenetical one. Only some of the analysed parameters show a statistically significant decrease in the triptorelin-treated groups.

  10. The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats

    Energy Technology Data Exchange (ETDEWEB)

    Camats, N. [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, F. [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, J.J. [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, 30120 El Palmar, Murcia (Spain); Calaf, J. [Servei de Ginecologia i Obstetricia, Hospital Universitari de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Martin-Mateo, M. [Departament de Pediatria, d' Obstetricia i Ginecologia i de Medicina Preventiva, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Caldes, M. Garcia, E-mail: Montserrat.Garcia.Caldes@uab.es [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)

    2009-10-02

    There is a controversy regarding the effects of the analogues of the gonadotrophin-releasing hormone (GnRH) in radiotherapy. This has led us to study the possible radio-protection of the ovarian function of a GnRH agonist analogue (GnRHa), triptorelin, in adult, female rats (Rattus norvegicus sp.). The effects of the X-irradiation on the oocytes of ovarian primordial follicles, with and without GnRHa treatment, were compared, directly in the female rats (F{sub 0}) with reproductive parameters, and in the somatic cells of the resulting foetuses (F{sub 1}) with cytogenetical parameters. In order to do this, the ovaries and uteri from 82 females were extracted for the reproductive analysis and 236 foetuses were obtained for cytogenetical analysis. The cytogenetical study was based on the data from 22,151 metaphases analysed. The cytogenetical parameters analysed to assess the existence of chromosomal instability were the number of aberrant metaphases (2234) and the number (2854) and type of structural chromosomal aberrations, including gaps and breaks. Concerning the reproductive analysis of the ovaries and the uteri, the parameters analysed were the number of corpora lutea, implantations, implantation losses and foetuses. Triptorelin confers radio-protection of the ovaries in front of chromosomal instability, which is different, with respect to the single and fractioned dose. The cytogenetical analysis shows a general decrease in most of the parameters of the triptorelin-treated groups, with respect to their controls, and some of these differences were considered to be statistically significant. The reproductive analysis indicates that there is also radio-protection by the agonist, although minor to the cytogenetical one. Only some of the analysed parameters show a statistically significant decrease in the triptorelin-treated groups.

  11. Evolution of the system of radiological protection

    International Nuclear Information System (INIS)

    2005-11-01

    One of the main challenges facing radiological protection experts is how to integrate radiological protection within modern concepts of and approaches to risk governance. It is within this context that the International Commission on Radiological Protection (ICRP) decided to develop new general recommendations to replace its Publication 60 recommendations of 1990. In the process of developing these new recommendations, the views of the ICRP have evolved significantly, largely due to stakeholder involvement that has been actively solicited by the ICRP. In this regard, it was upheld during the First Asian Regional Conference organised by the NEA in October 2002 that the implementation of the new system must allow for regional, societal and cultural differences. In order to ensure appropriate consideration of these differences, the NEA organised the Second Asian Regional Conference on the Evolution of the System of Radiological Protection. Held in Tokyo on 28-29 July 2004, the conference included presentations by the ICRP Chair as well as by radiological experts from Australia, China, Japan and Korea. Within their specific cultural and socio-political milieu, Asia-Pacific and western ways of thought on how to improve the current system of radiological protection were presented and discussed. These ways of thinking, along with a summary of the conference results, are described in these proceedings. (author)

  12. Radiation protection in nuclear energy. V.1

    International Nuclear Information System (INIS)

    1988-01-01

    The conference was convened to provide a forum for the exchange of international views on the principles of radiation protection for regulators and practitioners, to highlight issues of current importance, to examine the problems encountered in applying the principles of radiation protection, and, where possible, to identify generic solutions. A special session entitled ''The dose-response relationship: implications for nuclear energy'', and a panel on ''Radiation protection education and training'' were included in the conference programme. Refs, figs and tabs

  13. 27. Conference of the Nuclear Societies in Israel. Program and Papers

    International Nuclear Information System (INIS)

    2014-01-01

    The file contains the presentations of the 27 annual conference of the nuclear societies in Israel. The subjects of the conference are: aspects of nuclear energy and nuclear technology, applications of radioisotopes and radiation, radiation measurements, issues in radiation protection and radiation in medicine, the consequences of the Fukushima accident. During the conference awards will be given for outstanding student works

  14. Cognitive and Neuroplasticity Mechanisms by Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

    Science.gov (United States)

    Silverstein, Steven M.; Wang, Yushi; Keane, Brian P.

    2013-01-01

    Several authors have noted that there are no reported cases of people with schizophrenia who were born blind or who developed blindness shortly after birth, suggesting that congenital or early (C/E) blindness may serve as a protective factor against schizophrenia. By what mechanisms might this effect operate? Here, we hypothesize that C/E blindness offers protection by strengthening cognitive functions whose impairment characterizes schizophrenia, and by constraining cognitive processes that exhibit excessive flexibility in schizophrenia. After briefly summarizing evidence that schizophrenia is fundamentally a cognitive disorder, we review areas of perceptual and cognitive function that are both impaired in the illness and augmented in C/E blindness, as compared to healthy sighted individuals. We next discuss: (1) the role of neuroplasticity in driving these cognitive changes in C/E blindness; (2) evidence that C/E blindness does not confer protective effects against other mental disorders; and (3) evidence that other forms of C/E sensory loss (e.g., deafness) do not reduce the risk of schizophrenia. We conclude by discussing implications of these data for designing cognitive training interventions to reduce schizophrenia-related cognitive impairment, and perhaps to reduce the likelihood of the development of the disorder itself. PMID:23349646

  15. Cognitive and Neuroplasticity Mechanisms By Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

    Directory of Open Access Journals (Sweden)

    Steven eSilverstein

    2013-01-01

    Full Text Available Several authors have noted that there are no reported cases of people with schizophrenia who were born blind or who developed blindness shortly after birth, suggesting that congenital or early (C/E blindness may serve as a protective factor against schizophrenia. By what mechanisms might this effect operate? Here, we hypothesize that C/E blindness offers protection by strengthening cognitive functions whose impairment characterizes schizophrenia, and by constraining cognitive processes that exhibit excessive flexibility in schizophrenia. After briefly summarizing evidence that schizophrenia is fundamentally a cognitive disorder, we review areas of perceptual and cognitive function that are both impaired in the illness and augmented in C/E blindness, as compared to healthy sighted individuals. We next discuss: 1 the role of neuroplasticity in driving these cognitive changes in C/E blindness; 2 evidence that C/E blindness does not confer protective effects against other mental disorders; and 3 evidence that other forms of C/E sensory loss (e.g., deafness do not reduce the risk of schizophrenia. We conclude by discussing implications of these data for designing cognitive training interventions to reduce schizophrenia-related cognitive impairment, and perhaps to reduce the likelihood of the development of the disorder itself.

  16. Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.

    Directory of Open Access Journals (Sweden)

    Chi Young Chang

    Full Text Available Myeloperoxidase (MPO functions as a key molecular component of the host defense system against diverse pathogens. We have previously reported that increased MPO levels and activity is a distinguishing feature of rotenone-exposed glial cells, and that either overactivation or deficiency of MPO leads to pathological conditions in the brain. Here, we provide that modulation of MPO levels in glia by resveratrol confers protective effects on rotenone-induced neurotoxicity. We show that resveratrol significantly reduced MPO levels but did not trigger abnormal nitric oxide (NO production in microglia and astrocytes. Resveratrol-induced down-regulation of MPO, in the absence of an associated overproduction of NO, markedly attenuated rotenone-triggered inflammatory responses including phagocytic activity and reactive oxygen species production in primary microglia and astrocytes. In addition, impaired responses of primary mixed glia from Mpo (-/- mice to rotenone were relieved by treatment with resveratrol. We further show that rotenone-induced neuronal injury, particularly dopaminergic cell death, was attenuated by resveratrol in neuron-glia co-cultures, but not in neurons cultured alone. Similar regulatory effects of resveratrol on MPO levels were observed in microglia treated with MPP(+, another Parkinson's disease-linked neurotoxin, supporting the beneficial effects of resveratrol on the brain. Collectively, our findings provide that resveratrol influences glial responses to rotenone by regulating both MPO and NO, and thus protects against rotenone-induced neuronal injury.

  17. The 16. CLI national conference

    International Nuclear Information System (INIS)

    Junod, Bernard; Cherie-Challine, Laurence; Laurier, Dominique; Setbon, Michel; Bontoux, Jean; Ancelin, Gerad; Niquet, Gerard; Kessler, Emmanuel; Lacoste, Andre-Claude; Combrexelle, Jean-Denis; Garcier, Yves; Huiban, Franck; Quesne, Benoit; Fontaine, Nicole; Oudiz, Andre

    2004-12-01

    This document gathers contributions presented during a conference held in December 2004. After introductions speeches, contributions addressed the following topics: the new regulation related to the radiation protection of workers, radiation protection in nuclear power plants and advances performed over the last ten years, the coordination of field monitoring actions in the domain of radiation protection, the medical monitoring of workers exposed to ionizing radiations in INBs. A recorded intervention of the Minister of Industry is reported, as well as workshop reports, and a presentation of a Cd-Rom produced by the IRSN on the nuclear risk and its management

  18. 48 CFR 1552.223-71 - EPA Green Meetings and Conferences.

    Science.gov (United States)

    2010-10-01

    ... provision or language substantially the same as the provision in solicitations for meetings and conference services. EPA Green Meetings and Conferences (MAY 2007) (a) The mission of the EPA is to protect human... information about environmentally preferable features and practices your facility will have in place for the...

  19. 40 CFR 179.50 - Conduct at oral hearings or conferences.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Conduct at oral hearings or conferences. 179.50 Section 179.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... dignity and observe the same standards of practice and ethics that would be required of parties in a...

  20. Nuclear at Niagara. 32nd Annual Canadian Nuclear Society conference and 35th CNS/CNA student conference

    International Nuclear Information System (INIS)

    2011-01-01

    The 32nd Annual Canadian Nuclear Society Conference and 35th CNS/CNA Student Conference was held in Niagara Falls, Ontario, Canada on June 5-8, 2011. The theme of the conference, 'Nuclear at Niagara', brought together scientists, engineers, technologists, senior management, government officials, and students interested in all aspects of nuclear science and technology and its applications, including nuclear power generation, fuel production, uranium mining and refining, management of radioactive wastes and used fuel. Other topics include medical and industrial uses of radionuclides, occupational and environmental radiation protection, the science and technology of nuclear fusion, and associated activities in research and development. and applications of energy from the atom. The central objective of this conference was to exchange views on how nuclear science and technology can best serve the needs of humanity, now and in the future. Over 400 delegates from across Canada and other nuclear countries were in attendance.

  1. Radiation Hygiene Days 1998. Conference Proceedings of the 21-st Radiation Hygiene Days

    Energy Technology Data Exchange (ETDEWEB)

    Cabanekova, H; Durcik, M; Nikodemova, D [eds.; Institute of Preventive and Clinical Medicine, Bratislava (Slovakia)

    1999-12-31

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection. The proceedings consists of a following sections: (1) Radiation protection - new trends, legislation; (2) Nuclear energetics; (3) Expositions of ionizing radiation in medicine; (4) Ionizing radiation in environment and working conditions; (5) Radon in environment and working conditions. (J.K.)

  2. Radiation Hygiene Days 1998. Conference Proceedings of the 21-st Radiation Hygiene Days

    International Nuclear Information System (INIS)

    Cabanekova, H.; Durcik, M.; Nikodemova, D.

    1998-01-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection. The proceedings consists of a following sections: (1) Radiation protection - new trends, legislation; (2) Nuclear energetics; (3) Expositions of ionizing radiation in medicine; (4) Ionizing radiation in environment and working conditions; (5) Radon in environment and working conditions. (J.K.)

  3. Implementation of the resolutions passed on the occasion of the 3rd International North Sea Protection Conference

    International Nuclear Information System (INIS)

    1993-01-01

    This pamphlet reports about measures which are currently taken by the Government and Laender to protect the North Sea. The consistent policy of reducing all long-lived, toxic and bioaccumulating substances is continued through implementation of the conference resolutions, e.g. realization of a 50% reduction of pollutants (36 substances) coming from rivers and from the atmosphere from 1985 to 1995. Corresponding reductions of nitrogen and phosphorus were agreed on. A 70% reduction was demanded for the particularly hazardous substances dioxin, mercury, cadmium and lead. According to forecasts through 1995 the Federal Republic of Germany is among the most efficient nations. Most of the mentioned substances will be reduced by 50%. The ground has been prepared well in the past, and the Government and the Lands have been concentrating their attention in the past two years on problems of national organization and supervision. Further North Sea protection efforts are required in spite of the high pollution abatement standard and in spite of the favorable forecasts. (orig./HSCH) [de

  4. Papers of All-Polish Conference on Nuclear Techniques in Industry, Medicine, Agriculture and Environmental Protection; Referaty Krajowej Konferencji Technika Jadrowa w Przemysle, Medycynie, Rolnictwie i Ochronie Srodowiska

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    These proceedings comprise papers presented at All-Polish Conference on nuclear techniques in industry, medicine, agriculture and environmental protection. Most of the papers are in the field of uses of radiation sources and particle beams in industry, radiation chemistry, nuclear medicine and dosimetry, environmental sciences.

  5. 9. European TRIGA users' conference. Papers and abstracts

    International Nuclear Information System (INIS)

    1986-01-01

    Operation and maintenance experience, new developments and improvements of TRIGA reactors, fuel management, radiation protection, licensing, uses for research and isotope production are discussed at the Conference

  6. Immersion vaccination against Yersinia ruckeri O1, biotype 2 confers cross protection against Y. ruckeri O1 biotype 1

    DEFF Research Database (Denmark)

    Raida, Martin Kristian; Neumann, Lukas; Kragelund Strøm, Helene

    A new biotype 2 of Y. ruckeri O1, which lacks motility has proven highly virulent for rainbow trout, and is causing disease in cultured trout even in fish vaccinated with commercial ERM biotype 1 vaccines. Not much is known about immunity against biotype 2, and therefore have we produced a Y...... resulted in very low mortalities with no significant difference in mortality between vaccinated and mock-vaccinated fish. Challenge with biotype 1 resulted in a significantly lower mortality (P=0.0001) in the vaccinated group. This result was confirmed 15 months post vaccination (P... 2 confers significant cross protection against biotype 1....

  7. Hyperoxic preconditioning fails to confer additional protection against ischemia-reperfusion injury in acute diabetic rat heart.

    Science.gov (United States)

    Pourkhalili, Khalil; Hajizadeh, Sohrab; Akbari, Zahra; Dehaj, Mansour Esmaili; Akbarzadeh, Samad; Alizadeh, Alimohammad

    2012-01-01

    Experimental studies show that detrimental effects of ischemia-reperfusion (I/R) injury can be attenuated by hyperoxic preconditioning in normal hearts, however, there are few studies about hyperoxia effects in diseased myocardium. The present study was designed to assess the cardioprotective effects of hyperoxia pretreatment (≥ 95 % O2) in acute diabetic rat hearts. Normal and one week acute diabetic rats were either exposed to 60 (H60) and 180 (H180) min of hyperoxia or exposed to normal atmospheric air (21 % O2). Then hearts were isolated immediately and subjected to 30 min of regional ischemia followed by 120 min of reperfusion. Infarct size, cardiomyocyte apoptosis, enzymes release and ischemia induced arrhythmias were determined. Heart of diabetic control rats had less infarct size and decreased LDH and CK-MB release compared to normal hearts. 60 and 180 min of hyperoxia reduced myocardial infarct size and enzymes release in normal hearts. 180 min of hyperoxia also decreased cardiomyocytes apoptosis in normal state. On the other hand, protective values of hyperoxia were not significantly different in diabetic hearts. Moreover, hyperoxia reduced severity of ventricular arrhythmias in normal rat hearts whereas; it did not confer any additional antiarrhythmic protection in diabetic hearts. These findings suggest that diabetic hearts are less susceptible to ischemia-induced arrhythmias and infarction. Hyperoxia greatly protects rat hearts against I/R injury in normal hearts, however, it could not provide added cardioprotective effects in acute phase of diabetes.

  8. Nuclear at Niagara. 32nd Annual Canadian Nuclear Society conference and 35th CNS/CNA student conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The 32nd Annual Canadian Nuclear Society Conference and 35th CNS/CNA Student Conference was held in Niagara Falls, Ontario, Canada on June 5-8, 2011. The theme of the conference, 'Nuclear at Niagara', brought together scientists, engineers, technologists, senior management, government officials, and students interested in all aspects of nuclear science and technology and its applications, including nuclear power generation, fuel production, uranium mining and refining, management of radioactive wastes and used fuel. Other topics include medical and industrial uses of radionuclides, occupational and environmental radiation protection, the science and technology of nuclear fusion, and associated activities in research and development. and applications of energy from the atom. The central objective of this conference was to exchange views on how nuclear science and technology can best serve the needs of humanity, now and in the future. Over 400 delegates from across Canada and other nuclear countries were in attendance.

  9. International Conference on Low Doses of Ionising Radiation

    International Nuclear Information System (INIS)

    McEwan, A.C.

    1998-01-01

    Is there a threshold? and is a little radiation good for you? were two questions raised at the International Conference on Low Doses of Ionising Radiation : Biological Effects and Regulatory Control, jointly organised by the IAEA and WHO, and convened in Seville, Spain, over 17-21 November 1997. The answer to both these questions appears to be 'Maybe', but the answer has no present implications for radiation protection practice and regulation. The conference which had over 500 participants from 65 countries, was organised around ten fora which explored basic molecular mechanisms of radiation effects, through to radiation protection principles and implementation in practices and interventions. Each forum was introduced by an overview presentation by an invited keynote speaker. Brief presentations of a few of the proffered papers followed, and then open discussion. There was opportunity for all proffered papers to be presented as posters. The fora, which occupied 3 full days, were preceded by reports on biological effects of radiation from international orgnaisations, and on related international conferences held in the recent past. The fora were followed by round table presentations of regulatory control and scientiFic research, and a summary session drawing together conclusions on the topic areas of the conference. (author)

  10. XXXIX Days of Radiation Protection. Proceedings of Presentations and Posters

    International Nuclear Information System (INIS)

    2018-01-01

    The publication has been set up as a proceedings of presented presentations and posters on the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The main conference topics are focused on current problems in radiation protection and radioecology. In this proceedings totally 55 presentations and posters are included. The Conference consists of following sections: (I) Radiation protection, consequences of implementation of the EU2013/59 directive in the Czech Republic and the Slovak Republic); (II) Radiation protection in the application of ionizing radiation in medicine; (III) Dosimetry and metrology of external and internal irradiation; (IV) Natural sources of ionizing radiation, national radon programs; (V) Nuclear energy, the concept of decommissioning of nuclear power plants in terms of radiation protection; (VI) Use of standards of radiation protection in emergency management; (VII) Biological effects of radiation and estimation of irradiation risk.

  11. 76 FR 76713 - California Independent System Operator Corporation; Notice of Technical Conference

    Science.gov (United States)

    2011-12-08

    ...) proposal to eliminate convergence bidding at intertie scheduling points. Take notice that such conference...'s proposal to eliminate convergence bidding at intertie scheduling points. A subsequent notice... Act of 1973. For accessibility accommodations please send an email to [email protected] or call...

  12. Proceedings of European Medical Physics and Engineering Conference

    International Nuclear Information System (INIS)

    2012-01-01

    This publication is a compilation of papers presented at the at the European Medical Physics and Engineering Conference, which incorporates 11th National Conference of the Bulgarian Society of Biomedical Physics and Engineering (BSBPE) and 6th Conference of the European Federation of Organizations for Medical Physics (EFOMP). The reports are grouped in following scientific sessions: 1) Radiation therapy; 2) Biomedical engineering; 3) Education and training; 4) Biophysical methods for diagnostics and therapy; 5) Diagnostic and interventional radiology; 6) Modelling and information technology; 7) Dosimetry and standards; 8) Nuclear medicine and 9) Radiation protection. The individual papers are recorded in INIS as separate items

  13. Occupational radiation protection: Protecting workers against exposure to ionizing radiation. Contributed papers

    International Nuclear Information System (INIS)

    2003-07-01

    Occupational exposure to ionizing radiation can occur in a range of industries, mining and milling; medical institutions, educational and research establishments and nuclear fuel cycle facilities. The term 'occupational exposure' refers to the radiation exposure incurred by a worker, which is attributable to the worker's occupation and committed during a period of work. According to the latest (2000) Report of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), an estimated 11 million workers are monitored for exposure to ionizing radiation. They incur radiation doses attributable to their occupation, which range from a small fraction of the global average background exposure to natural radiation up to several times that value. It should be noted that the UNSCEAR 2000 Report describes a downward trend in the exposure of several groups of workers, but it also indicates that occupational exposure is affecting an increasingly large group of people worldwide. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS), which are co-sponsored by, inter alia, the International Atomic Energy Agency (IAEA), the International Labour Organization (ILO), the OECD Nuclear Energy Agency (NEA) and the World Health Organization (WHO), establish a system of radiation protection which includes radiation dose limits for occupational exposure. Guidance supporting the requirements of the BSS for occupational protection is provided in three interrelated Safety Guides, jointly sponsored by the IAEA and the ILO. These Guides describe, for example, the implications for employers in discharging their main responsibilities (such as setting up appropriate radiation protection programmes) and similarly for workers (such as properly using the radiation monitoring devices provided to them). The IAEA i organized its first International Conference on Occupational Radiation Protection. The

  14. Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases: report of the First International African Vaccinology Conference.

    Science.gov (United States)

    Wiysonge, Charles Shey; Waggie, Zainab; Hawkridge, Anthony; Schoub, Barry; Madhi, Shabir Ahmed; Rees, Helen; Hussey, Gregory

    2016-01-01

    One means of improving healthcare workers' knowledge of and attitudes to vaccines is through running vaccine conferences which are accessible, affordable, and relevant to their everyday work. Various vaccinology conferences are held each year worldwide. These meetings focus heavily on basic science with much discussion about new developments in vaccines, and relatively little coverage of policy, advocacy, and communication issues. A negligible proportion of delegates at these conferences come from Africa, home to almost 40% of the global burden of vaccine-preventable diseases. To the best of our knowledge, no major vaccinology conference has ever been held on the African continent apart from World Health Organization (WHO) meetings. The content of the first International African Vaccinology Conference was planned to be different; to focus on the science, with a major part of discussions being on clinical, programmatic, policy, and advocacy issues. The conference was held in Cape Town, South Africa, from 8 to 11 November 2012. The theme of the conference was "Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases". There were more than 550 registered participants from 55 countries (including 37 African countries). There were nine pre-conference workshops, ten plenary sessions, and 150 oral and poster presentations. The conference discussed the challenges to universal immunisation in Africa as well as the promotion of dialogue and communication on immunisation among all stakeholders. There was general acknowledgment that giant strides have been made in Africa since the global launch of the Expanded Programme on Immunisation in 1974. For example, there has been significant progress in introducing new and under-utilised vaccines; including hepatitis B, Haemophilus influenza type b, pneumococcal conjugate, rotavirus, meningococcal A conjugate, and human papillomavirus vaccines. In May 2012, African countries

  15. 77 FR 38306 - GFIRST Conference Stakeholder Evaluation

    Science.gov (United States)

    2012-06-27

    ...), National Cyber Security Division (NCSD), United States Computer Emergency Readiness Team (US-CERT) will... of Homeland Security, National Protection and Programs Directorate, Office of Cybersecurity and... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0116] GFIRST Conference Stakeholder...

  16. Evolution of the system of radiological protection

    International Nuclear Information System (INIS)

    2007-01-01

    The OECD Nuclear Energy Agency (NEA) has actively participated in discussions with the International Commission on Radiological Protection (ICRP) regarding the development of new recommendations that will replace those in ICRP Publication 60, which has long served as the international standard in this field. Part of this development process has involved the organisation of seven international workshops, including the First and Second Asian Regional Conferences on the Evolution of the System of Radiological Protection which took place in Tokyo, Japan in October 2002 and July 2004. The Third Asian Regional Conference was held on 5-6 July 2006, also in Tokyo. The main objective of these conferences was to ensure that the views and concerns of relevant Asian stakeholders, such as regulatory authorities, industry, professional societies and NGO, could be expressed and discussed with the ICRP. The three conferences provided the ICRP with specific views on how new recommendations could best be developed to address regulatory and implementation needs in the Asian context. These proceedings summarize the results and key discussions of the Third Asian Regional Conference. (author)

  17. Café e saúde humana: um enfoque nas substâncias presentes na bebida relacionadas às doenças cardiovasculares Coffee and human health: a focus on the substances of the beverage related to cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Fabiana Accioly de Lima

    2010-12-01

    Full Text Available O café é a bebida mais consumida no Brasil e no mundo ocidental. O fato de ser uma bebida tão popular, aliado à sua importância econômica, explica o interesse por estudos sobre o café, desde a sua composição até seus efeitos na saúde humana. Dentre as diversas substâncias presentes na composição química do café, além dos nutrientes, destacam-se a cafeína, os diterpenos cafestol e kahweol e os ácidos clorogênicos, o que faz do café uma importante fonte dietética destes compostos. Muitos estudos têm verificado a influência de seus constituintes na saúde, principalmente a cafeína vs a elevação da pressão arterial; o cafestol e o kahweol vs a dislipidemia; e ácidos clorogênicos vs proteção cardiovascular, por suas propriedades antioxidantes. Este artigo tem como objetivo apresentar de forma sucinta a importância da bebida e sua composição química, os mecanismos fisiológicos envolvidos na elevação da pressão arterial e do colesterol sérico atribuíveis ao café, bem como estudos selecionados que verificaram a associação do consumo da bebida com estas doenças cardiovasculares.Coffee is the most consumed beverage in the Western world, including Brazil. The fact that it is one the most popular beverages and its worldwide consumption and economic importance explain the interest for studies on coffee, from its composition to its effects on human health. In addition to the nutrients, its various components include caffeine, the diterpenes cafestol and kahweol, and chlorogenic acids, with coffee being an important dietary source of these compounds. Many studies have verified the association between its constituents and health, especially caffeine and high blood pressure, cafestol and kahweol and dyslipidemias, and chlorogenic acids and cardiovascular protection from their antioxidant properties. This article aims to succinctly present the importance and composition of the drink, the physiological mechanisms

  18. Stockholm conference. Summary of the international conference on the security of material in Stockholm, Sweden

    International Nuclear Information System (INIS)

    Hoskins, Richard

    2001-01-01

    Preventing illicit uses of nuclear material and radioactive sources was a major international concern even before the spectre of nuclear terrorism was raised by terrorist attacks in September 2001. At an IAEA international conference in Stockholm, Sweden, convened in May 2001, international experts examined ways and means of strengthening systems for the protection of nuclear and radioactive material. The Conference - formally called 'Security of Material: Measures to Prevent, Intercept and Respond to Illicit Uses of Nuclear Material and Radioactive Sources' - was attended by more than 300 experts from around the world. It was organized by the IAEA in cooperation with the European Police Office (Europol), the International Criminal Police Organization - Interpol (ICPO-Interpol), and the World Customs Organization (WCO), and hosted by the Swedish Nuclear Power Inspectorate. In the Conference Summary Document, participants underscored the importance of establishing stronger systems for nuclear security, and they outlined a number of steps for the future in particular areas. Following are excerpts from the Document. More information on the Conference is accessible on the IAEA's WorldAtom Web site at http://www.iaea.org/ worldatom/Press/P r elease/2001/ prn0110.shtml

  19. Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines.

    Directory of Open Access Journals (Sweden)

    Orit Gat

    2011-11-01

    Full Text Available Antibiotic-resistant Salmonella enterica serovar Paratyphi A, the agent of paratyphoid A fever, poses an emerging public health dilemma in endemic areas of Asia and among travelers, as there is no licensed vaccine. Integral to our efforts to develop a S. Paratyphi A vaccine, we addressed the role of flagella as a potential protective antigen by comparing cell-associated flagella with exported flagellin subunits expressed by attenuated strains.S. Paratyphi A strain ATCC 9150 was first deleted for the chromosomal guaBA locus, creating CVD 1901. Further chromosomal deletions in fliD (CVD 1901D or flgK (CVD 1901K were then engineered, resulting in the export of unpolymerized FliC, without impairing its overall expression. The virulence of the resulting isogenic strains was examined using a novel mouse LD(50 model to accommodate the human-host restricted S. Paratyphi A. The immunogenicity of the attenuated strains was then tested using a mouse intranasal model, followed by intraperitoneal challenge with wildtype ATCC 9150.Mucosal (intranasal immunization of mice with strain CVD 1901 expressing cell-associated flagella conferred superior protection (vaccine efficacy [VE], 90% against a lethal intraperitoneal challenge, compared with the flagellin monomer-exporting mutants CVD 1901K (30% VE or CVD 1901D (47% VE. The superior protection induced by CVD 1901 with its cell-attached flagella was associated with an increased IgG2a:IgG1 ratio of FliC-specific antibodies with enhanced opsonophagocytic capacity.Our results clearly suggest that enhanced anti-FliC antibody-mediated clearance of S. Paratyphi A by phagocytic cells, induced by vaccines expressing cell-associated rather than exported FliC, might be contributing to the vaccine-induced protection from S. Paratyphi A challenge in vivo. We speculate that an excess of IgG1 anti-FliC antibodies induced by the exported FliC may compete with the IgG2a subtype and block binding to specific phagocyte Fc

  20. The fourth conference on nuclear science and engineering in Australia, 2001. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This conference, with the theme 'New Nuclear Century' consists of invited papers supported by contributed posters on the following topics: nuclear research and ANSTO's Replacement Research Reactor; Australian uranium resources; radioactive waste management; low-level radiation, radiation protection, nuclear safety, the environment and sustainable development; application of nuclear energy in Nuclear Medicine, non-destructive testing; nuclear science and technology for the future and nuclear education.

  1. The fourth conference on nuclear science and engineering in Australia, 2001. Conference handbook

    International Nuclear Information System (INIS)

    2001-01-01

    This conference, with the theme 'New Nuclear Century' consists of invited papers supported by contributed posters on the following topics: nuclear research and ANSTO's Replacement Research Reactor; Australian uranium resources; radioactive waste management; low-level radiation, radiation protection, nuclear safety, the environment and sustainable development; application of nuclear energy in Nuclear Medicine, non-destructive testing; nuclear science and technology for the future and nuclear education

  2. The 22. CLI national conference

    International Nuclear Information System (INIS)

    Niel, Jean-Christophe; Lachaume, Jean-Luc; Comets, Marie-Pierre; Delalonde, Jean-Claude; Revol, Henri; Calafat, Alexis; Goellner, Jerome; Gilloire, Christine; Vicaud, Alain; Minon, Jean-Paul; Guiberteau, Philippe; Bietrix, Philippe

    2010-12-01

    This document gathers contributions presented during a conference held in December 2010. After introduction speeches and a focus of some updates, this conference comprised two round tables. The first one addressed the management of urban growth about INBs with the participation of representatives of the ASN, of the Department of technological risks within the Ministry of Ecology, of a CLI, of EDF, and of an association for the protection of the environment. The second round table addressed the continuation of reactor exploitation, the monitoring of the environment and public information, with representatives of the ASN, of a CLI, of the CEA, and of the ONDRAF (the Belgium agency in charge of the management of radioactive wastes)

  3. STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

    DEFF Research Database (Denmark)

    Skouboe, Morten K; Knudsen, Alice; Reinert, Line S

    2018-01-01

    In recent years, there has been an increasing interest in immunomodulatory therapy as a means to treat various conditions, including infectious diseases. For instance, Toll-like receptor (TLR) agonists have been evaluated for treatment of genital herpes. However, although the TLR7 agonist imiquimod...... herpes simplex virus (HSV) 2 replication and improved the clinical outcome of infection. More importantly, local application of CDNs at the genital epithelial surface gave rise to local IFN activity, but only limited systemic responses, and this treatment conferred total protection against disease...... to TLRs, STING is expressed broadly, including in epithelial cells. Here we report that natural and non-natural STING agonists strongly induce type I IFNs in human cells and in mice in vivo, without stimulating significant inflammatory gene expression. Systemic treatment with 2'3'-cGAMP reduced genital...

  4. 19th Radiation Hygiene Days. Conference Proceedings

    International Nuclear Information System (INIS)

    1995-01-01

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The proceedings consists of a following chapters: (1) Invited presentation; (2) Nuclear accident: management and instrumentation; (3) Low activity in environmental; (4) Radon: sources, doses and effects; (5) Radiation protection in nuclear medicine; (6) Nuclear power plants: radiation safety. (J.K.)

  5. 19th Radiation Hygiene Days. Conference Proceedings.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The publication has been set up as a proceedings of the conference dealing with health protection during work with ionizing radiation for different activities which involve the handling of ionizing radiation sources. The proceedings consists of a following chapters: (1) Invited presentation; (2) Nuclear accident: management and instrumentation; (3) Low activity in environmental; (4) Radon: sources, doses and effects; (5) Radiation protection in nuclear medicine; (6) Nuclear power plants: radiation safety. (J.K.).

  6. Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge.

    Science.gov (United States)

    Yang, Xinghong; Clapp, Beata; Thornburg, Theresa; Hoffman, Carol; Pascual, David W

    2016-10-17

    There remains a need for an improved livestock vaccine for brucellosis since conventional vaccines are only ∼70% efficacious, making some vaccinated animals susceptible to Brucella infections. To address this void, a vaccine capable of evoking protective immunity, while still being sufficiently attenuated to produce minimal disease, is sought. In this pursuit, the ΔnorD ΔznuA B. abortus-lacZ (termed as znBAZ) was developed to be devoid of functional norD and znuA B. abortus genes, and to contain the lacZ as a marker gene. The results show that znBAZ is highly attenuated in mouse and human macrophages, and completely cleared from mouse spleens within eight weeks post-vaccination. Producing less splenic inflammation, znBAZ is significantly more protective than the conventional RB51 vaccine by more than four orders of magnitude. Vaccination with znBAZ elicits elevated numbers of IFN-γ + , TNF-α + , and polyfunctional IFN-γ + TNF-α + CD4 + and CD8 + T cells in contrast to RB51-vaccinated mice, which show reduced numbers of proinflammatory cytokine-producing T cells. These results demonstrate that znBAZ is a highly efficacious vaccine candidate capable of eliciting diverse T cell subsets that confer protection against parenteral challenge with virulent, wild-type B. abortus. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis.

    Science.gov (United States)

    Willett, Jonathan W; Herrou, Julien; Czyz, Daniel M; Cheng, Jason X; Crosson, Sean

    2016-09-30

    The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response to infection by a B. abortus strain lacking σ(E1) (ΔrpoE1), and identified pathological and immunological features that distinguish ΔrpoE1-infected mice from wild-type (WT), and that correspond with clearance of ΔrpoE1 from the host. ΔrpoE1 infection was indistinguishable from WT in terms of splenic bacterial burden, inflammation and histopathology up to 6weeks post-infection. However, Brucella-specific serum IgG levels in ΔrpoE1-infected mice were 5 times higher than WT by 4weeks post-infection, and remained significantly higher throughout the course of a 12-week infection. Total IgG and Brucella-specific IgG levels peaked strongly in ΔrpoE1-infected mice at 6weeks, which correlated with reduced splenomegaly and bacterial burden relative to WT-infected mice. Given the difference in immune response to infection with wild-type and ΔrpoE1, we tested whether ΔrpoE1 confers protective immunity to wild-type challenge. Mice immunized with ΔrpoE1 completely resisted WT infection and had significantly higher serum titers of Brucella-specific IgG, IgG2a and IFN-γ after WT challenge relative to age-matched naïve mice. We conclude that immunization of BALB/c mice with the B. abortus GSR pathway mutant, ΔrpoE1, elicits an adaptive immune response that confers significant protective immunity against WT infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Technical conference of the section 'Genetic Engineering and Environmental Protection'

    International Nuclear Information System (INIS)

    Spoettle, M.; Koller, U.; Haury, H.J.

    2001-01-01

    This conference was held on 13 November 2000 by the GSF Research Centre for Ecology and Health on behalf of the Bavarian State Minister of Regional Development and the Environment. It was attended by about 50 scientists working in this field and 50 representatives of universities and other scientific institutions, who presented new findings of their research projects. (orig.)

  9. IgM but not IgG monoclonal anti-Nocardia brasiliensis antibodies confer protection against experimental actinomycetoma in BALB/c mice.

    Science.gov (United States)

    Gonzalez-Suarez, Maria L; Salinas-Carmona, Mario C; Pérez-Rivera, Isabel

    2009-10-01

    Nocardia brasiliensis is a facultative intracellular microorganism that produces a human chronic infection known as actinomycetoma. Human and mouse anti-N. brasiliensis antibody response identify P24, P26 and P61 immunodominant antigens. In this work, we generated immunoglobulin M (IgM) and IgG monoclonal antibodies (mAbs) specific to immunodominant P61 antigen. The monoclonal IgM (NbM1) and IgG2a (NbG1) antibodies were assessed for their in vitro bactericidal activity, in vivo protective effect and ability to block catalase activity. These mAbs specifically recognized P61, but they did not inhibit its enzyme activity. The in vitro bactericidal effect of NbG1 was higher than the killing ability of the IgM mAb. In vivo experiments with a murine model of experimental infection with N. brasiliensis injected into rear footpads was used to test the effect of NbM1 and NbG1. The negative untreated group developed a chronic actinomycetoma within 4 weeks. IgM mAbs conferred protection to BALB/c mice infected with N. brasiliensis. IgG mAb lacked this protective effect. IgM mAb showed a dose-response correlation between antibody concentration and lesion size. These results demonstrate that humoral immune response mediated by antigen-specific IgM antibody protects against an intracellular bacterial infection.

  10. Intermediate rough Brucella abortus S19Δper mutant is DIVA enable, safe to pregnant guinea pigs and confers protection to mice.

    Science.gov (United States)

    Lalsiamthara, Jonathan; Gogia, Neha; Goswami, Tapas K; Singh, R K; Chaudhuri, Pallab

    2015-05-21

    Brucella abortus S19 is a smooth strain used as live vaccine against bovine brucellosis. Smooth lipopolysaccharide (LPS) is responsible for its residual virulence and serological interference. Rough mutants defective of LPS are more attenuated but confers lower level of protection. We describe a modified B. abortus S19 strain, named as S19Δper, which exhibits intermediate rough phenotype with residual O-polysaccharide (OPS). Deletion of perosamine synthetase gene resulted in substantial attenuation of S19Δper mutant without affecting immunogenic properties. It mounted strong immune response in Swiss albino mice and conferred protection similar to S19 vaccine. Immunized mice produced higher levels of IFN-γ, IgG2a and thus has immune response inclined towards Th1 cell mediated immunity. Sera from immunized animals did not show agglutination reaction with RBPT antigen and thus could serve as DIVA (Differentiating Infected from Vaccinated Animals) vaccine. S19Δper mutant displayed more susceptibility to serum complement mediated killing and sensitivity to polymyxin B. Pregnant guinea pigs injected with S19Δper mutant completed full term of pregnancy and did not cause abortion, still birth or birth of weak offspring. S19Δper mutant with intermediate rough phenotype displayed remarkable resemblance to S19 vaccine strain with improved properties of safety, immunogenicity and DIVA capability for control of bovine brucellosis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. JV Task 94 - Air Quality V: Mercury, Trace Elements, SO3, and Particulate Matter Conference

    Energy Technology Data Exchange (ETDEWEB)

    Thomas A. Erickson

    2007-01-31

    This final report summarizes the planning, preparation, facilitation and production, and summary of the conference entitled 'Air Quality V: Mercury, Trace Elements, SO{sub 3}, and Particulate Matter,' held September 18-21, 2005, in Arlington, Virginia. The goal of the conference was to build on the discussions of the first four Air Quality Conferences, providing further opportunity for leading representatives of industry, government, research institutions, academia, and environmental organizations to discuss the key interrelationships between policy and science shaping near-term regulations and controls and to assist in moving forward on emerging issues that will lead to acceptable programs and policies to protect human health, the environment, and economic growth. The conference was extremely timely, as it was the last large conference prior to publication of the U.S. Environmental Protection Agency's final regulations for mercury control from coal-fired utilities, and provided a forum to realistically assess the status of mercury controls in relation to the new regulations.

  12. The tenth Arab conference on peaceful uses of atomic energy

    International Nuclear Information System (INIS)

    2010-01-01

    This conference includes the paper presented at the tenth Arab conference of the peaceful uses of Nuclear Atomic Energy that is organized by AAEA (Arab Atomic Energy Agency) in cooperation with Iraqi Ministry of Science and Technology and Kurdistan government , held in Erbil (Iraq) from 12-16 December 2010. This conference consists of three volumes covering the following concepts: Analysis and Material Improvement, Soil fertility, Water Recourse Management, Nuclear Medicine and Biological Irradiation, Isotopes Production, Improvement of Plant and Animal Production, Decommissioning and Dismantling of Nuclear Facilities, Radioactive Waste Management, Nuclear Safety and Security of Radiation Protection, Pest Control and Food Irradiation Processing

  13. Proceedings of the International Conference on Modern Radiotherapy. Advances and Challenges in Radiation Protection of Patients; Actes de la conference internationale sur la radiotherapie moderne. Defis et progres dans le domaine de la radioprotection des patients

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-15

    The use of ionizing radiation in medicine has led to major improvements in the diagnosis and treatment of human diseases. While bringing new benefits for cancer treatment, modern radiotherapy also poses new challenges in terms of radiation protection of patients. Prevention of radiotherapy incidents and accidents is a major issue in this area. In December 2009, the French Nuclear Safety Authority (ASN) organised the 1. international conference on radiation protection of patients in radiotherapy. The major objective of the conference was to provide a platform for exchanging experience, and reviewing the actions implemented to improve the radiation safety in radiotherapy both at national and international level. The expected result was: - to reach a consensus about the necessity to strengthen existing international actions for prevention of incidents and accidents, - to set up an international cooperation to improve management for overexposed patients, - to outline a strategy for strengthening regulation, - to contribute to the elaboration of an international scale to rate patient related events for communication and reporting purpose. 360 delegates from 50 countries across the world participated at the 3-day conference. 41 presentations were made and 67 posters were displayed. The conference brought together a broad spectrum of expertise: scientists, health professionals, medical devices manufacturers, risk management specialists, radiation protection experts, representatives from Radiation Protection and Health Authorities as well as patient's associations. The programme covered both scientific and medical issues, such as patient sensitivity to ionising radiation and the treatment of complications. It also provided scope to discuss the benefits and risks of modern radiotherapy and to explore treatment safety issues from various perspectives, including human resources, expertise, education and training along with control and prevention strategies. The

  14. 5th International Conference on Engineering Surveying Brijuni, September 22-24, 2011

    Directory of Open Access Journals (Sweden)

    Rinaldo Paar

    2011-12-01

    Full Text Available 5th International Conference on Engineering Surveying was held on the Brijuni Islands from 22 to 24 September 2011. The conference organizers were the Department of Surveying Faculty of Civil Engineering at the Slovak University of Technology in Bratislava and the Institute for Applied Geodesy at the Faculty of Geodesy, University of Zagreb, with the FIG Commission 6. The conference was held under the patronage of the Ministry of Environmental Protection, Physical Planning and Construction of the Republic of Croatia. The conference took place in the Castrum Congress Hall of Hotel Neptun-Istra. The official language of the conference was English. The conference was attended by 70 representatives from Croatia, Slovenia, Serbia, Kosovo, Austria, Germany, Hungary, Greece, Czech Republic and Slovakia, and a total of 40 papers were presented.

  15. Radiological protection of patients in diagnostic and interventional radiology, nuclear medicine and radiotherapy. Contributed papers

    International Nuclear Information System (INIS)

    2001-01-01

    An International Conference on the Radiological Protection of Patients in Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy organized by the International Atomic Energy Agency and co-sponsored by the European Commission, the Pan American Health Organization and the World Health Organization was held in Malaga, Spain, from 26 to 30 March 2001. The Government of Spain hosted this Conference through the Ministerio de Sanidad y Consumo, the Consejo de Seguridad Nuclear, the Junta de Andalucia, the Universidad de Malaga and the Grupo de Investigacion en Proteccion Radiologica de la Universidad de Malaga (PRUMA). The Conference was organized in co-operation with the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), the International Commission on Radiological Protection (ICRP) and the following professional societies: International Organization of Medical Physicists (IOMP), International Radiation Protection Association (IRPA), International Society of Radiation Oncology (ISRO), International Society of Radiology (ISR), International Society of Radiographers and Radiological Technologists (ISRRT) and World Federation of Nuclear Medicine and Biology (WFNMB). This publication contains contributed papers submitted to the Conference Programme Committee. The papers are in one of the two working languages of this Conference, English and Spanish. The topics covered by the Conference are as follows: Radiological protection of patients in general diagnostic radiology (radiography), Radiological protection of patients in general diagnostic radiology (fluoroscopy), Radiological protection issues in specific uses of diagnostic radiology, such as mammography and computed tomography (with special consideration of the impact of digital techniques), Radiological protection in interventional radiology, including fluoroscopy not carried out by radiologists, Radiological protection of patients in nuclear medicine, Developing and

  16. Radiological protection of patients in diagnostic and interventional radiology, nuclear medicine and radiotherapy. Contributed papers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    An International Conference on the Radiological Protection of Patients in Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy organized by the International Atomic Energy Agency and co-sponsored by the European Commission, the Pan American Health Organization and the World Health Organization was held in Malaga, Spain, from 26 to 30 March 2001. The Government of Spain hosted this Conference through the Ministerio de Sanidad y Consumo, the Consejo de Seguridad Nuclear, the Junta de Andalucia, the Universidad de Malaga and the Grupo de Investigacion en Proteccion Radiologica de la Universidad de Malaga (PRUMA). The Conference was organized in co-operation with the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), the International Commission on Radiological Protection (ICRP) and the following professional societies: International Organization of Medical Physicists (IOMP), International Radiation Protection Association (IRPA), International Society of Radiation Oncology (ISRO), International Society of Radiology (ISR), International Society of Radiographers and Radiological Technologists (ISRRT) and World Federation of Nuclear Medicine and Biology (WFNMB). This publication contains contributed papers submitted to the Conference Programme Committee. The papers are in one of the two working languages of this Conference, English and Spanish. The topics covered by the Conference are as follows: Radiological protection of patients in general diagnostic radiology (radiography), Radiological protection of patients in general diagnostic radiology (fluoroscopy), Radiological protection issues in specific uses of diagnostic radiology, such as mammography and computed tomography (with special consideration of the impact of digital techniques), Radiological protection in interventional radiology, including fluoroscopy not carried out by radiologists, Radiological protection of patients in nuclear medicine, Developing and

  17. Benefits conferred by "timid" ants: active anti-herbivore protection of the rainforest tree Leonardoxa africana by the minute ant Petalomyrmex phylax.

    Science.gov (United States)

    Gaume, Laurence; McKey, Doyle; Anstett, Marie-Charlotte

    1997-10-01

    In this study, we demonstrate that an important benefit provided by the small host-specific ant Petalomyrmex phylax to its host plant Leonardoxa africana is efficient protection against herbivores. We estimate that in the absence of ants, insect herbivory would reduce the leaf area by about one-third. This contributes considerably to the fitness of the plant. Our estimates take into account not only direct damage, such as removal of leaf surface by chewing insects, but also the effects of sucking insects on leaf growth and expansion. Sucking insects are numerically predominant in this system, and the hitherto cryptic effects of ant protection against the growth-reducing effects of sucking insects accounted for half of the total estimated benefit of ant protection. We propose that the small size of workers confers a distinct advantage in this system. Assuming that resource limitation implies a trade off between size and number of ants, and given the small size of phytophagous insects that attack Leonardoxa, we conclude that fine-grained patrolling by a large number of small workers maximises protection of young leaves of this plant. Since herbivores are small and must complete their development on the young leaves of Leonardoxa, and since a high patrolling density is required for a fine-grained search for these enemies, numerous small ants should provide the most effective protection of young leaves of Leonardoxa. We also discuss other factors that may have influenced worker size in this ant.

  18. Proceedings of GeoHalifax 2009 : the 62. Canadian geotechnical conference and 10. joint CGS/IAH-CNC groundwater conference

    Energy Technology Data Exchange (ETDEWEB)

    Lake, C.; Fenton, G. [Dalhousie Univ., Halifax, NS (Canada); Taylor, B. [Stantec Consulting Ltd., Surrey, BC (Canada); Ferguson, G. [Saint Francis Xavier Univ., Antigonish, NS (Canada)] (comps.) (and others)

    2009-07-01

    More than 500 delegates from industry, government, universities and research centres attended this conference to exchange professional knowledge on research and development that affects all sectors of geotechnical engineering, applied geology and hydrogeology. The conference also highlighted recent geoenvironmental achievements. The geotechnical sessions were entitled: soil mechanics; soil mechanics and brownfields; foundation engineering; landslide and slopes engineering; rock mechanics; risk assessment; reliability-based design; geoenvironmental issues; transportation geotechniques; marine geotechniques and geohazards; non-textbook soils and waste soils; covers and liners; instrumentation; harbour and shoreline geotechniques; geosynthetic mechanically stabilized earth (MSE) systems; cold regions and climate change; computer applications; regional hydrogeology; groundwater-surface water interaction; well hydraulics; radioactive waste management; groundwater sustainability; source water protection; mine waters; field techniques in hydrogeology; and hydrogeology of fractured rocks. The conference featured more than 230 presentations, of which 37 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  19. International conference on individual monitoring of ionising radiation

    International Nuclear Information System (INIS)

    Vanhavere, Filip

    2016-01-01

    This special issue of the journal Radiation Protection Dosimetry is dedicated to the Proceedings of the International Conference on Individual Monitoring of Ionising Radiation (IM2015), which is the fifth of a series of conferences dealing with individual monitoring. This conference series is initiated by EURADOS, the European Radiation Dosimetry Group, and is organised every 5 years. In 2015, the conference was jointly organised by the Belgian Nuclear Research Centre (SCK.CEN), AV Controlatom, and the Vrije Universiteit Brussel. It brought together scientists from regulatory authorities, individual monitoring services (IMS), research bodies, European networks and companies, for the purpose of facilitating the dissemination of knowledge, exchanging experiences and promoting new ideas in the field of individual monitoring. After the conference, 124 papers were submitted for publication in these peer-reviewed proceedings. From these, 103 were finally accepted for publication. The help of the numerous referees and the guest editors is very much appreciated. These proceedings provide a full image of the IM2015 conference. The high-level publications will be useful to improve the state of individual monitoring all over the world and aim to inspire many scientists to continue their work on a better monitoring of radiologically exposed workers

  20. Selective protection. Selektivschutz

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    TC 2, ''Transmission and distribution of electrical energy'', held its meeting on selective protection on 16/17 March 1983 at Nuremberg. The main reason for the development of computerized protective systems is their ability to solve a wide range of tasks using only a few, high-integrated systems, i.e. on the software side instead of the hardware side. At the meeting, experts from industrial companies and public utilities reviewed the status and trends of protective systems engineering. Scientific studies and operating experience were presented. Separate abstracts were prepared for 2 papers in this conference proceedings volume.

  1. Proceedings of the International Conference Nuclear Energy for New Europe 2007

    International Nuclear Information System (INIS)

    Jencic, I.; Lenosek, M.

    2007-01-01

    International Conference Nuclear Energy for New Europe is an annual meeting of the Nuclear Society of Slovenia. The conference attempts to address the prospects of nuclear energy in present and future Europe. Increasing electricity consumption, global warming, security of supply, all these issues contribute to the so-called nuclear renaissance. Nuclear renaissance was also the leading theme of this year's conference in Portoroz which was attended by 172 participants from 22 countries. Topics are: reactor physics, thermal hydraulics, probabilistic safety assessment, severe accidents, nuclear power plants operation, radiation protection, radioactive waste, fusion, nuclear materials and nuclear renaissance

  2. ETAI 2003: 6. national conference with international participation. Proceedings

    International Nuclear Information System (INIS)

    Stankovski, Mile J.

    2003-01-01

    ETAI 2005 is the seventh of the series of theme conferences organized by the Society for ETAI of the Republic of Macedonia. The previous ones include ETAI '82, '85, '89, '93, 2000 and 2003. Traditionally, the Conference is held in the ambient of the reach rarity of the nature and the culture of Ohrid Coastal Area, protected by UNESCO. The scope of the Conference, following its cross-disciplinary character, is aimed towards studying and exposing both the theoretical and applied aspects in the field of Electronics, Telecommunications, Automatics and Informatics. The aim of the Conference is directed towards encouraging and stimulating the professional exchange of information and knowledge among people from academic institutions and from business and industry enterprises in the fields covered by ETAI. At the same time the Conference will enable a close and direct get-togetherness framework important for sharing people ideas and professional knowledge for the benefit of the common progress. The program of the ETAI 2003 contains three plenary lectures and 20 regular sessions including 85 contributed papers

  3. 46 CFR 153.933 - Chemical protective clothing.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Chemical protective clothing. 153.933 Section 153.933 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... Protective Clothing”, Third Edition, 1987, available from the American Conference of Governmental Industrial...

  4. Conference Report: Environmental Protection in the Global Twentieth Century: International Organizations, Networks and Diffusion of Ideas and Policies

    DEFF Research Database (Denmark)

    Meyer, Jan-Henrik

    the environment. Notably, IOs were central forums for negotiating and placing environmental protection on the international political agenda. It is widely assumed that 1972 – the year of the first UN conference on the human environment in Stockholm and of the publication of the Club of Rome report "Limits...... entrepreneurs, selecting, defining, diffusing and translating ideas about the environment in the course of the twentieth century? Secondly, which structural conditions facilitated – and at times inhibited – the diffusion or transfer of policy ideas? It can safely be assumed that the embedding of IOs in national...... and influential individuals – who transmitted and translated environmental ideas from the OECD Environment Committee in the early 1970s to the Brundtland Commission in the 1980s. The latter sought to overcome the apparent contradictions between developmental and environmental goals, advocating the notion...

  5. Part B: Summary report of the decision conferences held in the USSR -October-November, 1990

    International Nuclear Information System (INIS)

    French, S.

    1992-01-01

    From the outset in planning the International Project it was appreciated that the evaluation of the protective measures adopted within the Soviet Union could not be achieved by considering only radiological protection aspects. Social and political factors, inter alia, would also drive the decision making. Accordingly, the project description, as approved by the International Advisory Committee, included the use of multi-attribute decision aiding techniques to investigate and capture these factors. As the Project evolved, the specification of the manner in which these techniques were to be used was progressively clarified until it was decided to hold four decision conferences, one each in the Republics of the Ukraine and Byelorussia and the Russian Federation, and one at All-Union level. The purposes of these decision conferences were: to enable some of the decision problems related to the Chernobyl accident to be structured efficiently and thus clarify and elucidate issues; to summarize for the International Project the key socio-economic and political factors that together with the physical, radiological and medical evidence influence the relocation and protective measures taken in the Republics; to illustrate the use and potential benefits of formal decision analysis methods and the techniques of decision conferencing for the resolution of complex issues. Subsequently, a fifth decision conference was held at which representatives from the earlier conferences met to build a summary model that represented the main issues and concerns. This report describes the running of these decision conferences, the principal conclusions that may be drawn from the evidence which was elicited, and the direction in which consensus may evolve between the many parties to the decisions concerning protective and relocation measures in the Soviet Union

  6. [Omentin: Role in insulin resistance, inflammation and cardiovascular protection].

    Science.gov (United States)

    Hernández-Díaz, Adrián; Arana-Martínez, Julio C; Carbó, Roxana; Espinosa-Cervantes, Román; Sánchez-Muñoz, Fausto

    2016-01-01

    The omentin is an adipokine, which role is due to the capacity of regulate metabolic (insulin sensitivity) and anti-inflammatory activities, thus conferring vascular protection during obesity and diabetes mellitus type 2. By this, it is important to know the mechanisms by which omentin confers cardiovascular protection, with the purpose of establish omentin a possible therapeutic target or molecule on this scenario. Copyright © 2015 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.

  7. 5. European conference of TRIGA users. Papers and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1978-07-01

    The main conference topics were: Operation and maintenance experience of the TRIGA reactors; Development of new Low Enrichment Fuels (LEU); Dose assessments noble gas releases; Radiation protection and dosimetry measurements; Research reactors programs and experiments; and Application of TRIGA reactors.

  8. 5. European conference of TRIGA users. Papers and abstracts

    International Nuclear Information System (INIS)

    1978-01-01

    The main conference topics were: Operation and maintenance experience of the TRIGA reactors; Development of new Low Enrichment Fuels (LEU); Dose assessments noble gas releases; Radiation protection and dosimetry measurements; Research reactors programs and experiments; and Application of TRIGA reactors

  9. Proceedings, 15th central hardwood forest conference

    Science.gov (United States)

    David S. Buckley; Wayne K. Clatterbuck; [Editors

    2007-01-01

    Proceedings of the 15th central hardwood forest conference held February 27–March 1, 2006, in Knoxville, TN. Includes 86 papers and 30 posters pertaining to forest health and protection, ecology and forest dynamics, natural and artificial regeneration, forest products, wildlife, site classification, management and forest resources, mensuration and models, soil and...

  10. 11th National Conference on Science, Policy, and the Environment: Our Changing Oceans

    Energy Technology Data Exchange (ETDEWEB)

    Peter Saundry

    2012-04-17

    On January 19-21, 2011, The National Council for Science and the Environment (NCSE) successfully convened its 11th National Conference on Science, Policy and the Environment: Our Changing Oceans in Washington, DC at the Ronald Reagan Building and International Trade Center. Over 1,247 participants attended the conference, representing federal, state and local governments, university and colleges across the US, civil society organizations, the business community, and international entities. In addition, the conference was webcast to an audience across several states. The conference provided a forum to examine the profound changes our ocean will undergo over the next 25-50 years and share various perspectives on the new research, tools, and policy initiatives to protect and sustain our ocean. Conference highlights and recommendations are available to the public on NCSE's conference website, www.OurChangingOceans.org.

  11. Assessment of the international meeting of radiation protection professionals

    International Nuclear Information System (INIS)

    Nikodemova, Denisa; Cabanekova, Helena

    2012-01-01

    The conclusions from and main agenda of the conference are summarized. The conference was divided into 8 sections, dealing with biological effects of ionizing radiation, general aspects of radiation protection, dosimetry and metrology of ionizing radiation, radiation protection problems in nuclear power plants, management of nuclear radiation emergencies, radiation load of patients and staff during medical applications of ionizing radiation (radiodiagnosis, nuclear medicine and radiation oncology), control of exposure to radiation from natural sources in the environment and at workplaces, and education in radiation protection. The programme included round-table discussions devoted to the Fukushima nuclear power plant accident, optimization of the radiation load of children in radiology, and recent advances in the radon risk countermeasures area. (orig.)

  12. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.

    Science.gov (United States)

    Becattini, Barbara; Zani, Fabio; Breasson, Ludovic; Sardi, Claudia; D'Agostino, Vito Giuseppe; Choo, Min-Kyung; Provenzani, Alessandro; Park, Jin Mo; Solinas, Giovanni

    2016-09-01

    Obesity and insulin resistance are associated with oxidative stress, which may be implicated in the progression of obesity-related diseases. The kinase JNK1 has emerged as a promising drug target for the treatment of obesity and type 2 diabetes. JNK1 is also a key mediator of the oxidative stress response, which can promote cell death or survival, depending on the magnitude and context of its activation. In this article, we describe a study in which the long-term effects of JNK1 inactivation on glucose homeostasis and oxidative stress in obese mice were investigated for the first time. Mice lacking JNK1 (JNK1(-/-)) were fed an obesogenic high-fat diet (HFD) for a long period. JNK1(-/-) mice fed an HFD for the long term had reduced expression of antioxidant genes in their skin, more skin oxidative damage, and increased epidermal thickness and inflammation compared with the effects in control wild-type mice. However, we also observed that the protection from obesity, adipose tissue inflammation, steatosis, and insulin resistance, conferred by JNK1 ablation, was sustained over a long period and was paralleled by decreased oxidative damage in fat and liver. We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.-Becattini, B., Zani, F., Breasson, L., Sardi, C., D'Agostino, V. G., Choo, M.-K., Provenzani, A., Park, J. M., Solinas, G. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage. © FASEB.

  13. Proceedings of the Stakeholders Conference on Review of the Radiation Health and Safety Bill 2010

    International Nuclear Information System (INIS)

    2010-01-01

    Kenya enacted a radiation protection law in 1982 largely to control the use of radiation sources in medical field. The use of radiation has now been extended to sectors and significantly increased in the medical field. Radiation protection Board held its second a stake holders conference to review the radiation health and safety law to make more inclusive and the scope of the proposed legislation relevant. The conference discussed usage, classification and regulation of conventional radiation sources and the associated radiation practices. The conference discussed an overview on the recent development towards the use of nuclear energy for electricity generation by Ministry of Energy.It was noted 95% of public exposure to radiation comes conventional sources used in medicine, industry, agriculture, education and 5% of public exposure comes from natural sources and power plants

  14. Autovaccination confers protection against Devriesea agamarum associated septicemia but not dermatitis in bearded dragons (Pogona vitticeps).

    Science.gov (United States)

    Hellebuyck, Tom; Van Steendam, Katleen; Deforce, Dieter; Blooi, Mark; Van Nieuwerburgh, Filip; Bullaert, Evelien; Ducatelle, Richard; Haesebrouck, Freddy; Pasmans, Frank; Martel, An

    2014-01-01

    Devrieseasis caused by Devriesea agamarum is a highly prevalent disease in captive desert lizards, resulting in severe dermatitis and in some cases mass mortality. In this study, we assessed the contribution of autovaccination to devrieseasis control by evaluating the capacity of 5 different formalin-inactivated D. agamarum vaccines to induce a humoral immune response in bearded dragons (Pogona vitticeps). Each vaccine contained one of the following adjuvants: CpG, incomplete Freund's, Ribi, aluminium hydroxide, or curdlan. Lizards were administrated one of the vaccines through subcutaneous injection and booster vaccination was given 3 weeks after primo-vaccination. An indirect ELISA was developed and used to monitor lizard serological responses. Localized adverse effects following subcutaneous immunization were observed in all but the Ribi adjuvanted vaccine group. Following homologous experimental challenge, the incomplete Freund's as well as the Ribi vaccine were observed to confer protection in bearded dragons against the development of D. agamarum associated septicemia but not against dermatitis. Subsequently, two-dimensional gelelectrophoresis followed by immunoblotting and mass spectrometry was conducted with serum obtained from 3 lizards that showed seroconversion after immunisation with the Ribi vaccine. Fructose-bisphosphate aldolase and aldo-keto reductase of D. agamarum reacted with serum from the latter lizards. Based on the demonstrated seroconversion and partial protection against D. agamarum associated disease following the use of formalin-inactivated vaccines as well as the identification of target antigens in Ribi vaccinated bearded dragons, this study provides promising information towards the development of a vaccination strategy to control devrieseasis in captive lizard collections.

  15. Autovaccination confers protection against Devriesea agamarum associated septicemia but not dermatitis in bearded dragons (Pogona vitticeps.

    Directory of Open Access Journals (Sweden)

    Tom Hellebuyck

    Full Text Available Devrieseasis caused by Devriesea agamarum is a highly prevalent disease in captive desert lizards, resulting in severe dermatitis and in some cases mass mortality. In this study, we assessed the contribution of autovaccination to devrieseasis control by evaluating the capacity of 5 different formalin-inactivated D. agamarum vaccines to induce a humoral immune response in bearded dragons (Pogona vitticeps. Each vaccine contained one of the following adjuvants: CpG, incomplete Freund's, Ribi, aluminium hydroxide, or curdlan. Lizards were administrated one of the vaccines through subcutaneous injection and booster vaccination was given 3 weeks after primo-vaccination. An indirect ELISA was developed and used to monitor lizard serological responses. Localized adverse effects following subcutaneous immunization were observed in all but the Ribi adjuvanted vaccine group. Following homologous experimental challenge, the incomplete Freund's as well as the Ribi vaccine were observed to confer protection in bearded dragons against the development of D. agamarum associated septicemia but not against dermatitis. Subsequently, two-dimensional gelelectrophoresis followed by immunoblotting and mass spectrometry was conducted with serum obtained from 3 lizards that showed seroconversion after immunisation with the Ribi vaccine. Fructose-bisphosphate aldolase and aldo-keto reductase of D. agamarum reacted with serum from the latter lizards. Based on the demonstrated seroconversion and partial protection against D. agamarum associated disease following the use of formalin-inactivated vaccines as well as the identification of target antigens in Ribi vaccinated bearded dragons, this study provides promising information towards the development of a vaccination strategy to control devrieseasis in captive lizard collections.

  16. Radiation protection and communication. Sociology and communication impact in radiation protection

    International Nuclear Information System (INIS)

    Berne, G.; Bicheron, G.; Franco, P.

    2000-01-01

    Communication about nuclear energy was the subject of this conference. Different examples of communications are detailed in fields as different as impact of iodine 131 release in waste waters or public information about radiation protection, the north Cotentin radioecology group or what information to give to the patients in nuclear medicine. (N.C.)

  17. 78 FR 67338 - Marine Protected Areas Federal Advisory Committee; Public Meeting

    Science.gov (United States)

    2013-11-12

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Marine Protected Areas... the Marine Protected Areas Federal Advisory Committee (Committee). The web conference calls are open..., MPA FAC, National Marine Protected Areas Center, 1305 East West Highway, Silver Spring, Maryland 20910...

  18. Conference on soldiers, civilians and environment protection against contaminations

    International Nuclear Information System (INIS)

    1994-01-01

    The military and civil aspects of radiation protection have been discussed. The special emphasize has been done on contamination monitoring of environment, soldier radiological protection during hypothetical warfare, radiological health hazard assessment, post Chernobyl contamination control of environment and food products in Poland, dose equivalent estimation and radiometric control equipment used in military and civil service

  19. Conference report : PERM-IT '97

    International Nuclear Information System (INIS)

    Smyth, V.; Yeabsley, A.

    1997-01-01

    The PERM-IT conference (Physics Engineering Radiation Medicine with a special emphasis on Information Technology) which was held in Adelaide with an attendance of about 250, was the joint annual meeting of the Australasian Radiation Protection Society, the Australasian College of Physical Scientists and Engineers in Medicine, the College of Biomedical Engineers of the Institution of Engineers Australia and the Society for Medical and Biological Engineering. The program was organised with three parallel sessions running most of the time, with plenary sessions for items of particular interest featuring keynote speakers from around the world. Attendance at this conference allowed the opportunity to meet with colleagues in other regulatory agencies, and Australia has a number of these. But what should be done about radioactive waste? A universal groan is raised by radiation protection regulatory authority staff at this question. Plans are afoot to develop a whole of Australia radioactive waste repository with both burial and above ground facilities. An announcement on the suitability of various sites in order of preference is expected, but in the meantime, facilities are fragemented. Discussions were held with staff from the radiation standards section of the Australian Radiation Laboratory who face similar problems to NRL including reducing funding, the move to cost recovery, and working towards quality managment accreditation. Plans for a further intercomparison between the Australian and NZ primary standards are being made. (author)

  20. PARP-1 Variant Rs1136410 Confers Protection against Coronary Artery Disease in a Chinese Han Population: A Two-Stage Case-Control Study Involving 5643 Subjects

    Directory of Open Access Journals (Sweden)

    Xue-bin Wang

    2017-11-01

    Full Text Available Inhibition of poly(ADP-ribose polymerase (PARP may protect against coronary artery disease (CAD in animal models, and rs1136410, a non-synonymous single nucleotide polymorphism (SNP in PARP-1, has a potential impact on PARP activities in vitro. This two-stage case-control study, involving 2803 CAD patients and 2840 controls, aimed to investigate the associations of PARP-1 rs1136410 with CAD development, lipid levels, PARP activities, 8-hydroxy-2′-dexyguanosine (8-OHdG, and interleukin (IL-6 levels in a Chinese Han population. Assuming a recessive model, the variant genotype GG of SNP rs1136410 showed a significantly inverse association with CAD risk (adjusted odds ratio (OR = 0.73, P < 0.001, left main coronary artery (LMCA lesions (P = 0.003, vessel scores (P = 0.003, and modified Gensini scores (P < 0.001. There were significant correlations of SNP rs1136410 with higher levels of total cholesterol (TC and lower levels of high-density lipoprotein cholesterol (HDL-c. In gene-environment interaction analyses, participants with the variant genotype GG, but without smoking habit, type 2 diabetes mellitus, and hyperlipidemia, conferred an 84% (P < 0.001 decreased risk of CAD. The genotype-phenotype correlation analyses further supported the functional roles of SNP rs1136410 in decreasing PARP activities and 8-OHdG levels. Taken together, our data suggest that SNP rs1136410 may confer protection against CAD through modulation of PARP activities and gene-environment interactions in a Chinese Han population.

  1. Rio conference global environmental protection Agenda 21

    Energy Technology Data Exchange (ETDEWEB)

    Pinchera, G. (ENEA, Rome (Italy). Area Energia, Ambiente e Salute)

    1992-10-01

    In reviewing the work packages included in the Rio Earth's Summit Agenda 21, intended as an activities guideline for international cooperation to ensure environmental protection with sustainable growth for all nations, this paper points out the areas which present the greatest obstacles in the establishment of common accords and discusses the directions being taken to surmount these obstacles. A major obstacle concerns uncertaindes in specifying limits on carbon dioxide emissions and their effects on world climate. Another concerns suitable methods to help finance effective technology transfer to developing countries. With regard to the former problem, a 'no regret' approach has been proposed to limit current C02 reduction interventions to those levels which, in all certainty, would not incur any future regrets once scientific knowledge has advanced enough to allow more accurate assessments of greenhouse gas/climate change inter-relationships. With regard to the latter problem, attempts are being made to reduce possible negative impacts on the petroleum industry due to energy surcharges suggested as a source of funding for technology transfer/environmental protection programs.

  2. Radiation protection in nuclear energy. V.2

    International Nuclear Information System (INIS)

    1988-01-01

    The conference was convened to provide a forum for the exchange of international views on the principles of radiation protection for regulators and practitioners, to highlight issues of current importance, to examine the problems encountered in applying the principles of radiation protection, and, where possible, to identify generic solutions. The highlights of the conference were the sessions on the interface between nuclear safety and radiation protection, the evolution of radiation protection principles, exemption rules and accident experiences. The special session on the practical implications of the linear dose-response relationships also provoked particular interest. Although the session on optimization and decision aiding did not reveal any new developments, it did indicate an increasing emphasis on the optimization of radiation protection. A clear trend towards attaining lower collective doses per unit practice over a given time period, despite the increase in nuclear power plant capacity, is also apparent, although very few data on job-related worker doses have been published to date in the open literature. From the regulators' viewpoint, a very strong desire was expressed for a move towards regulatory strategies that exempt practices and sources causing insignificant individual and collective doses. Refs, figs and tabs

  3. Proceedings of papers. 3. Balkan Metallurgical Conference

    International Nuclear Information System (INIS)

    Mickovski, Jovan

    2003-01-01

    This Conference aims to be a central event in the metallurgy research of Balkan, fulfilling the goals to present the most outstanding relevant developments in modern metallurgy; to inspire high standards of excellence in pure and applied metallurgy research; to attract outstanding scientists to present central lectures on modem metallurgical research, and on the challenges imposed by the needs of society; to inspire the young generation of metallurgists in Balkan and other countries. Following these lines, the 3. Balkan Conference on Metallurgy will provide a unique opportunity for academic and industrial metallurgists from the Balkan countries and wider, to exchange ideas, expertise, and experience on topics related to the theme of the Conference - Balkan Metallurgy in Search for New Ways of Development. The aim of the organizers was to bring together distinguished experts, not only to present their work, but also to discuss the major scientific and technological challenges facing metallurgy in this millennium.The 6 sections of the conference were entitled: Section A: Extractive metallurgy; Section B: Physical metallurgy and materials science - ferrous metals and non ferrous metals; Section C: Management, maintenance control and optimization of metallurgical processes; Section D: New technologies and techniques; Section E: Refractory and powder; Section F: Corrosion and protection of metals. Papers relevant to INIS are indexed separately

  4. Nasal and skin delivery of IC31(®)-adjuvanted recombinant HSV-2 gD protein confers protection against genital herpes.

    Science.gov (United States)

    Wizel, Benjamin; Persson, Josefine; Thörn, Karolina; Nagy, Eszter; Harandi, Ali M

    2012-06-19

    Genital herpes caused by herpes simplex virus type 2 (HSV-2) remains the leading cause of genital ulcers worldwide. Given the disappointing results of the recent genital herpes vaccine trials in humans, development of novel vaccine strategies capable of eliciting protective mucosal and systemic immune responses to HSV-2 is urgently required. Here we tested the ability of the adjuvant IC31(®) in combination with HSV-2 glycoprotein D (gD) used through intranasal (i.n.), intradermal (i.d.), or subcutaneous (s.c.) immunization routes for induction of protective immunity against genital herpes infection in C57BL/6 mice. Immunization with gD plus IC31(®) through all three routes of immunization developed elevated gD-specific serum antibody responses with HSV-2 neutralizing activity. Whereas the skin routes promoted the induction of a mixed IgG2c/IgG1 isotype profile, the i.n. route only elicited IgG1 antibodies. All immunization routes were able to induce gD-specific IgG antibody responses in the vaginas of mice immunized with IC31(®)-adjuvanted gD. Although specific lymphoproliferative responses were observed in splenocytes from mice of most groups vaccinated with IC31(®)-adjuvanted gD, only i.d. immunization resulted in a significant splenic IFN-γ response. Further, immunization with gD plus IC31(®) conferred 80-100% protection against an otherwise lethal vaginal HSV-2 challenge with amelioration of viral replication and disease severity in the vagina. These results warrant further exploration of IC31(®) for induction of protective immunity against genital herpes and other sexually transmitted infections. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. 4. Climate protection forum of the State of Hessen: Protecting the climate profitably; 4. Hessisches Klimaschutzforum: Klimaschutz wirtschaftlich gestalten. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    Schweer, R. (ed.)

    2001-07-01

    The speeches held on the conference deal with the situation of the climate protection from a scientific viewpoint, the perspectives of the Kyoto protocol for insurances and the economy, the answers of economy to the climate change, the trade with hothouse gas emissions and the ways of financing climate protection.

  6. Proceedings of the third Radiation Physics Conference. Vol. 2

    International Nuclear Information System (INIS)

    Gomaa, M.A.; El-Behay, A.Z.; Hassib, G.M.; El-Naggar, A.M.

    1996-01-01

    The conference of radiation physics was held in 13-17 Nov. 1996 in cairo. The specialists of atomic energy authority and Al-Minia University discussed the biological radiation effects,radiation protection, applied radiation physics and material shielding studies were discussed at the meeting more than 400 page were presented

  7. Proceedings of the third Radiation Physics Conference. Vol. 2

    Energy Technology Data Exchange (ETDEWEB)

    Gomaa, M A; El-Behay, A Z; Hassib, G M; El-Naggar, A M [eds.

    1997-12-31

    The conference of radiation physics was held in 13-17 Nov. 1996 in cairo. The specialists of atomic energy authority and Al-Minia University discussed the biological radiation effects,radiation protection, applied radiation physics and material shielding studies were discussed at the meeting more than 400 page were presented.

  8. Cyber Resilience in de Bestuurskamer : The Grand Conference in Amsterdam

    NARCIS (Netherlands)

    Klaver, M.H.A.

    2013-01-01

    Op 16 oktober 2012 vond in Amsterdam The Grand Conference plaats. Deze conferentie werd georganiseerd door het Centre for the Protection of National lnfrastructure (CPNI.NL) in nauwe samenwerking met de Europese Commissie, de Europese Networkand Information Security Agency (ENISA), het Amerikaanse

  9. Materials of All-Polish Symposium Nuclear Techniques in Industry, Medicine, Agriculture and Environment Protection

    International Nuclear Information System (INIS)

    2005-01-01

    The All-Polish Symposium Nuclear Techniques in Industry, Medicine, Agriculture and Environment Protection is cyclic (in 3 year period) conference being a broad review of state of art and development of all nuclear branches cooperated with industry and other branches of national economy and public life in Poland. The conference has been divided in one plenary session and 6 problem sessions as follow: Environmental protection, earth sciences, protection of cultural objects; Industrial applications; applications in medicine, medical apparatus; measurement methods, simulations, experiment planning; radiation techniques; laboratories, metrology

  10. The 21st LH Gray Conference (June 4-6, 2008)

    Energy Technology Data Exchange (ETDEWEB)

    West, C. M. L. [Univ. of Manchester (United Kingdom); Martin, C. J. [Gartnavel Royal Hospital, Glasgow (United Kingdom); Sutton, D. G. [Ninewells Hospital and Medical School, Dundee (United Kingdom); Wright, E. G. [Ninewells Hospital and Medical School, Dundee (United Kingdom)

    2009-01-12

    The 21st LH Gray Conference, organised by the LH Gray Trust with the Society for Radiological Protection, brought together international experts in radiobiology, epidemiology and risk assessment, and scientists involved in diagnostic and therapeutic radiation exposure. The meeting - held in Edinburgh, Scotland 4-6 June 2008 - aimed to raise awareness, educate and share knowledge of important issues in radiation protection. A distinguished group of speakers discussed topics which included: non-targeted effects of radiation, exposure to high natural background radiation, non-cancer effects in Japanese bomb survivors, lessons learnt from Chernobyl, radiation in the workplace, biokinetic modelling, uncertainties in risk estimation, issues in diagnostic medical exposures, lessons leant from the polonium-210 incidence and how the radiobiology-radiation oncology community is needed to help society prepare for potential future acts of radiation terrorism. The conference highlighted the importance, relevance and topicality of radiobiology today.

  11. Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.

    Science.gov (United States)

    Kolb, Alexander L; Corridon, Peter R; Zhang, Shijun; Xu, Weimin; Witzmann, Frank A; Collett, Jason A; Rhodes, George J; Winfree, Seth; Bready, Devin; Pfeffenberger, Zechariah J; Pomerantz, Jeremy M; Hato, Takashi; Nagami, Glenn T; Molitoris, Bruce A; Basile, David P; Atkinson, Simon J; Bacallao, Robert L

    2018-04-01

    Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To identify changes in mitochondria protein expression in response to ischemic preconditioning, we isolated mitochondria from ischemic preconditioned kidneys and sham-treated kidneys as a basis for comparison. The proteomic screen identified highly upregulated proteins, including NADP+-dependent isocitrate dehydrogenase 2 (IDH2), and we confirmed the ability of this protein to confer cellular protection from injury in murine S3 proximal tubule cells subjected to hypoxia. To further evaluate the role of IDH2 in cell protection, we performed detailed analysis of the effects of Idh2 gene delivery on kidney susceptibility to ischemia-reperfusion injury. Gene delivery of IDH2 before injury attenuated the injury-induced rise in serum creatinine ( P <0.05) observed in controls and increased the mitochondria membrane potential ( P <0.05), maximal respiratory capacity ( P <0.05), and intracellular ATP levels ( P <0.05) above those in controls. This communication shows that gene delivery of Idh2 can confer organ-wide protection against subsequent ischemia-reperfusion injury and mimics ischemic preconditioning. Copyright © 2018 by the American Society of Nephrology.

  12. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Science.gov (United States)

    2011-10-17

    ... Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November 29, 2011, from 1 p.m. to 5 p.m. and... reliability that were identified in earlier Commission technical conferences. The conference also will discuss...

  13. 78 FR 19460 - Marine Protected Areas Federal Advisory Committee; Public Meeting

    Science.gov (United States)

    2013-04-01

    ... meeting via web conference call of the Marine Protected Areas Federal Advisory Committee (Committee). The..., Acting Designated Federal Officer, MPA FAC, National Marine Protected Areas Center, 1305 East West... Interior on implementation of Section 4 of Executive Order 13158, on marine protected areas. Matters to be...

  14. 12. U.S. TRIGA users conference. Papers and abstracts

    International Nuclear Information System (INIS)

    1990-01-01

    The Conference presentations were devoted to the following topics: new developments and improvements, including modifications of TRIGA reactors and equipment; experiments with TRIGA reactors (Neutron Radiography); radiochemistry, radioisotope production and beam irradiations (experiment applications, simulation); reactor physics - fuel utilization; reactor operation and maintenance experience; safety aspects, licensing and radiation protection

  15. NPP safety and personnel training. XII International conference. Abstracts

    International Nuclear Information System (INIS)

    2011-01-01

    The 12th International conference NPP Safety and Personnel Training took place in Obninsk, October 4-7, 2011. The issues of nuclear technologies safety are considered.The problems of life-cycle management of nuclear facilities are discussed. The criteria of assessment of physical protection systems of nuclear facilities are presented [ru

  16. γδ T cells confer protection against murine cytomegalovirus (MCMV.

    Directory of Open Access Journals (Sweden)

    Camille Khairallah

    2015-03-01

    Full Text Available Cytomegalovirus (CMV is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved in the response to CMV but their role in protection has not been firmly established and their dependency on other lymphocytes has not been addressed. Using C57BL/6 αβ and/or γδ T cell-deficient mice, we here show that γδ T cells are as competent as αβ T cells to protect mice from CMV-induced death. γδ T cell-mediated protection involved control of viral load and prevented organ damage. γδ T cell recovery by bone marrow transplant or adoptive transfer experiments rescued CD3ε-/- mice from CMV-induced death confirming the protective antiviral role of γδ T cells. As observed in humans, different γδ T cell subsets were induced upon CMV challenge, which differentiated into effector memory cells. This response was observed in the liver and lungs and implicated both CD27+ and CD27- γδ T cells. NK cells were the largely preponderant producers of IFNγ and cytotoxic granules throughout the infection, suggesting that the protective role of γδ T cells did not principally rely on either of these two functions. Finally, γδ T cells were strikingly sufficient to fully protect Rag-/-γc-/- mice from death, demonstrating that they can act in the absence of B and NK cells. Altogether our results uncover an autonomous protective antiviral function of γδ T cells, and open new perspectives for the characterization of a non classical mode of action which should foster the design of new γδ T cell based therapies, especially useful in αβ T cell compromised patients.

  17. 3. Annual conference 1982, June 9, Royal Hotel, Toronto, Canada. Proceedings

    International Nuclear Information System (INIS)

    Oberth, R.C.

    1982-01-01

    Papers presented at this conference cover the fields of thermalhydraulics, system design and analysis, system operation, environmental and radiation protection, reactor and fuel physics, fuel cycles and mining, safety systems and reliability, public and regulatory aspects, and nuclear power plant operators

  18. Ministers at IAEA Conference Call for Stronger Nuclear Security

    International Nuclear Information System (INIS)

    2013-01-01

    Full text: Despite substantial progress in strengthening nuclear security in recent years, more needs to be done worldwide to defend against the threat of nuclear terrorism and other malicious acts involving nuclear or radiological material, a Ministerial Declaration at the IAEA's International Conference on Nuclear Security: Enhancing Global Efforts stated today. More than 1 300 participants at the Conference, which is open to all 159 IAEA Member States, will analyse past and current efforts and consider how future challenges can best be met to ensure effective and sustainable nuclear security worldwide. The Conference, which started in Vienna today and ends on Friday, includes representatives from 123 countries and 21 governmental and non-governmental organizations. The Ministerial Declaration, adopted at a plenary session attended by 34 government ministers and other Heads of Delegation including the Conference President, Hungarian Foreign Affairs Minister Janos Martonyi, says they ''remain concerned about the threat of nuclear and radiological terrorism and of other malicious acts or sabotage related to facilities and activities involving nuclear and other radioactive material.'' The Declaration - the first of its kind for nuclear security - notes that all States are responsible for their own nuclear security, but that international cooperation is important in supporting States' efforts to fulfil their responsibilities. It affirms the central role of the IAEA in strengthening nuclear security globally, and leading coordination of international activities in this field. ''We encourage all States to maintain highly effective nuclear security, including physical protection, for all nuclear and other radioactive material, their transport, use and storage and their associated facilities, as well as protecting sensitive information and maintaining the necessary nuclear security systems and measures to assess and manage their nuclear security effectively,'' the

  19. Report on the 4th Conference on Environmental Science of the Carpathian Basin

    International Nuclear Information System (INIS)

    Kiss, A.Z.

    2008-01-01

    Complete text of publication follows. The main organizers of the conference were the Faculty of Science and Technology of the University of Debrecen and the Sapientia - Hungarian University of Transylvania, Faculty of Science and Art, Cluj-Napoca, Romania (the proposer of this series of conferences). The Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI) took part in the organization as its Hertelendi Ede Environmental Research Laboratory and the Ion Beam Application Laboratory are engaged in the study of the environment of the Carpathian Basin. Moreover the Department of Environmental Physics, run jointly by the University of Debrecen and ATOMKI, plays an important role in teaching environmental physics at the university. The conference was held on 28-29 March, 2008, in the building of the Regional Committee of the Hungarian Academy of Sciences (HAS) in Debrecen. The aim of the conference was to bring together scientists and students from different countries, involved in various aspects of environmental science and technology, since the common environmental problems of the Carpathian Basin to be solved make necessary the cooperation between them, living and working in different parts of the basin. The conference gave an opportunity to show the latest results in these fields, and in the same time it was an occasion for the young scientists to be introduced and to exchange experience. The scientific sections were the followings: environmental science and education, environmental chemistry, environmental physics, environmental geography, environmental protection and environmental technology, environmental biology and nature protection, landscape ecology and urban ecology. The number of registered participants (161) was the largest since the beginning (2005) of the conference series. They arrived from five countries (Hungary, Rumania, Slovakia, Croatia and Serbia), several institutions from 27 towns of the Carpathian Basin. The number of oral

  20. Abstracts of 3. International scientific-practical conference 'Semipalatinsk Test Site. Radiation Legacy and Non-proliferation Issues'

    International Nuclear Information System (INIS)

    2008-01-01

    The Conference gathered representatives of more than 25 countries and international organizations. In the Conference among with actual problems of current environment conditions in Kazakhstan, perspective trends in the field of radiation protection, radio-ecological and radiobiological research and issues of international co-operation in support of non-proliferation regime, other advanced scientific projects were considered [ru

  1. Book of Abstracts - International Conference 'Radon in Environment', Zakopane, 10-14 May 2009

    International Nuclear Information System (INIS)

    Mazur, J.; Kozak, K.; Kobol, I.

    2009-04-01

    The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences has been organizing since 2000 the serial conferences, traditionally called RADON IN ENVIRONMENT. This is the first international meeting, two previous conferences (in 2000 and 2005) were national. The conference covers the following topics: · radon and thoron in air, water and soil, · modelling of radon transport, · geological aspects, · measurement techniques and interpretation of results, · techniques of reducing radon concentrations, · health aspects, · protection against radon risk, · uranium and thorium series, · NORM and TENORM elements in environment, · law regulations, · information policy. The Conference takes place in Zakopane (southern part of Poland, about 100 km distance from Krakow) at the conference and holiday centre '' ANTALOWKA ''. Zakopane, beautifully situated at the foot of the Tatra mountains, offers a chance to take advantage of outdoor recreation and to become acquainted with the unique folklore of the local mountaineers. We do hope that the conference will provide a forum to explore and discuss new scientific initiatives and all participants will benefit from this meeting. (author)

  2. Proceedings of the 10. IASTED international conference on power and energy systems (PES 2008)

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, E. (ed.)

    2008-07-01

    This conference provided a forum to review new technologies and modelling strategies for power systems and to address issues related to artificial intelligence and power system design optimization. The role of renewable energy sources such as solar, wind and biomass energy in interconnected power systems were also reviewed. In addition, conference participants presented recent advances in distributed power generation; load shedding; fault diagnosis; energy storage; power system stability; and security of supply. The sessions of the conference were entitled: fault detection, diagnosis, protection and power quality; renewable, distributed, generation and power lines; power system analysis, operation and control; and electricity markets. The conference featured 43 presentations, of which 24 have been catalogued separately for inclusion in this database. refs., tabs. figs.

  3. A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice.

    Science.gov (United States)

    Ku, Zhiqiang; Liu, Qingwei; Ye, Xiaohua; Cai, Yicun; Wang, Xiaoli; Shi, Jinping; Li, Dapeng; Jin, Xia; An, Wenqi; Huang, Zhong

    2014-07-23

    Enterovirus 71(EV71) and coxsackievirus A16 (CA16) are responsible for hand, foot and mouth disease which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children. Co-circulation of and co-infection by both viruses underscores the importance and urgency of developing vaccines against both viruses simultaneously. Here we report the immunogenicity and protective efficacy of a bivalent combination vaccine comprised of EV71 and CA16 virus-like particles (VLPs). We show that monovalent EV71- or CA16-VLPs-elicited serum antibodies exhibited potent neutralization effect on the homotypic virus but little or no effect on the heterotypic one, whereas the antisera against the bivalent vaccine formulation were able to efficiently neutralize both EV71 and CA16, indicating there is no immunological interference between the two antigens with respect to their ability to induce virus-specific neutralizing antibodies. Passive immunization with monovalent VLP vaccines protected mice against a homotypic virus challenge but not heterotypic infection. Surprisingly, antibody-dependent enhancement (ADE) of disease was observed in mice passively transferred with mono-specific anti-CA16 VLP sera and subsequently challenged with EV71. In contrast, the bivalent VLP vaccine conferred full protection against lethal challenge by either EV71 or CA16, thus eliminating the potential of ADE. Taken together, our results demonstrate for the first time that the bivalent VLP approach represents a safe and efficacious vaccine strategy for both EV71 and CA16. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.

    Directory of Open Access Journals (Sweden)

    Simon H Apte

    Full Text Available Vaccines against many pathogens for which conventional approaches have failed remain an unmet public health priority. Synthetic peptide-based vaccines offer an attractive alternative to whole protein and whole organism vaccines, particularly for complex pathogens that cause chronic infection. Previously, we have reported a promising lipid core peptide (LCP vaccine delivery system that incorporates the antigen, carrier, and adjuvant in a single molecular entity. LCP vaccines have been used to deliver several peptide subunit-based vaccine candidates and induced high titre functional antibodies and protected against Group A streptococcus in mice. Herein, we have evaluated whether LCP constructs incorporating defined CD4(+ and/or CD8(+ T cell epitopes could induce epitope-specific T cell responses and protect against pathogen challenge in a rodent malaria model. We show that LCP vaccines failed to induce an expansion of antigen-specific CD8(+ T cells following primary immunization or by boosting. We further demonstrated that the LCP vaccines induced a non-specific type 2 polarized cytokine response, rather than an epitope-specific canonical CD8(+ T cell type 1 response. Cytotoxic responses of unknown specificity were also induced. These non-specific responses were able to protect against parasite challenge. These data demonstrate that vaccination with lipid core peptides fails to induce canonical epitope-specific T cell responses, at least in our rodent model, but can nonetheless confer non-specific protective immunity against Plasmodium parasite challenge.

  5. 1987 Oak Ridge model conference: Proceedings: Volume 3, Health and safety

    International Nuclear Information System (INIS)

    1987-01-01

    See the abstract for Volume I for general information on the conference. Topics discussed in Volume III include the use of models in handling hazardous materials, communication at waste sites, asbestos, regulatory decisions, emergency planning, training programs, occupational hazards, and protection of subcontractors

  6. Haztech Canada Halifax '91: 1st annual Atlantic onshore and offshore environmental conference

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    A conference on hazardous waste management presented papers on such topics as emergency response plans, legal aspects of hazardous and petroleum-related waste spills, groundwater protection, site remediation, waste treatment and disposal, polychlorinated biphenyls decontamination and analysis, waste-related aspects of offshore oil operations, community involvement in hazardous waste facility siting, municipal landfill siting, design and operation of resource recovery facilities, and bioremediation of hydrocarbon contamination. Separate abstracts have been prepared for 10 papers from this conference.

  7. International Conference 'Uranium legacy of Soviet Union in Central Asia: problems and way forward' Proceedings

    International Nuclear Information System (INIS)

    2012-01-01

    The goal of the conference is to discuss safe management of uranium mill tailings, remediation activities foreseen under Eurasian Economic Community in Kyrgyzstan and Tajikistan, existing problems and ways forward. A conference on this topic in Tajikistan with the support of the International Science and Technology Center and Norwegian Radiation Protection Authority is relevant and very important taken into account foreseen remediation activities starting from 2013.

  8. 2000 Yukon North Slope conference : The challenge of change : Summary report

    International Nuclear Information System (INIS)

    2001-01-01

    The proclamation of the Inuvialuit Final Agreement (IFA) took place in 1984, and the protection of the environment of the Yukon North Slope was ensured through new mechanisms provided in the Agreement. The creation of Ivvavik National Park and Herschel Island Territorial Park resulted from section 12 of the Agreement, as well as the Wildlife Management Advisory Council (North Slope). Designated as having a special conservation regime with protection of wildlife, habitat and traditional native use, the entire Yukon North Slope is of paramount importance. Promoting discussion among native organizations, government and the private sector is one of the mandates of the new management regime, under section 12(57) of the IFA. These discussions must deal with management coordination for the North Slope. The sixth Yukon North Slope Conference was held in September 2000, and this document summarizes the proceedings. The document was based on transcripts and reports from workshops held during the conference. In some instances, the material was edited for clarification. Approximately 100 delegates represented various interests ranging from academia to wildlife conservation organizations, from government to native organizations and others. The discussions included topics as varied as oil and gas development, climate change, ecological monitoring, wildlife populations, tourism development, implementation of the IFA, environmental assessment, and protected areas. Some of the recommendations emanating from the conference touched information dissemination on climate change and ecological monitoring, the establishment of a roundtable representing all stakeholders concerning environmental assessments for oil and gas development, and continued support for natives to maintain their cultural values and traditional uses among others. figs., 5 appendices

  9. ENTRIA workshop. Determine threshold values in radiation protection

    International Nuclear Information System (INIS)

    Diener, Lisa

    2015-01-01

    Threshold values affect our daily lives. Whether it concerns traffic or noise regulations, we all experience thresholds on a regular basis. But how are such values generated? The conference ''Determine Thres-hold Values in Radiation Protection'', taking place on January 27th 2015 in Braunschweig, focused on this question. The conference was undertaken in the context of the BMBF-funded interdisciplinary research project ''ENTRIA - Disposal Options for Radioactive Residues''. It aimed to stimulate a cross-disciplinary discussion. Spea-kers from different disciplinary backgrounds talked about topics like procedures of setting threshold values, standards for evaluating dosages, and public participation in the standardization of threshold values. Two major theses emerged: First, setting threshold values always requires considering contexts and protection targets. Second, existing uncertainties must be communicated in and with the public. Altogether, the conference offered lots of input and issues for discussion. In addition, it raised interesting and important questions for further and ongoing work in the research project ENTRIA.

  10. Abstracts Book of 3. All-Polish Conference on Radiochemistry and Nuclear Chemistry

    International Nuclear Information System (INIS)

    2001-01-01

    The development of radiochemistry and nuclear chemistry in Poland have been presented during the 3. All-Polish Conference on Radiochemistry and Nuclear Chemistry held in Kazimierz Dolny in May 2001. The broad range of problems connected with radiochemistry and nuclear chemistry application in environmental protection and quality control, nuclear medicine and radiation protection, radioactive waste processing and many other scientific and everyday problems solution have been extensively presented and discussed

  11. Proceedings of the international conference on emerging frontiers and challenges in radiation biology: abstracts

    International Nuclear Information System (INIS)

    Purohit, R.K.; Chakrawarti, Aruna; Agarwal, Manisha; Arora, Anil

    2012-01-01

    This abstract volume includes abstracts related to six technical sessions of the conference viz., Radiation induced genomic instability and bystander effects, Radiation dosimetry and dose limits, Radiation protection and nuclear technology application, Molecular diagnosis and targeted therapy for cancer, cancer care and chemoradiotherapy, health hazards of radiation and protection. Papers relevant to INIS are indexed separately

  12. The 68th Session of the International Labour Conference, June 1982.

    Science.gov (United States)

    International Labour Review, 1982

    1982-01-01

    This year's session adopted new standards such as maintenance of migrant workers' social security rights, protection of workers against unjustified dismissal, and vocational rehabilitation. This article describes the conference's examination of these technical agenda items, and its annual review of the application of Conventions and…

  13. Aerospace Environmental Technology Conference

    Science.gov (United States)

    Whitaker, A. F. (Editor)

    1995-01-01

    The mandated elimination of CFC's, Halons, TCA, and other ozone depleting chemicals and specific hazardous materials has required changes and new developments in aerospace materials and processes. The aerospace industry has been involved for several years in providing product substitutions, redesigning entire production processes, and developing new materials that minimize or eliminate damage to the environment. These activities emphasize replacement cleaning solvents and their application verifications, compliant coatings including corrosion protection systems, and removal techniques, chemical propulsion effects on the environment, and the initiation of modifications to relevant processing and manufacturing specifications and standards. The Executive Summary of this Conference is published as NASA CP-3297.

  14. 10. European TRIGA users conference. Papers and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-07-01

    The Tenth European TRIGA Users Conference was held in Vienna, September 14-16, 1988 under the sponsorship of the Atominstitut. The main areas of discussions were: Reactor operation and maintenance experiences; New developments and improvements of TRIGA components and systems, including instrumentation; Fuel and fuel management; Safety aspects, licensing and radiation protection; Experiments with TRIGA reactors; Radiochemistry, radioisotope production and NAA; and Reactor physics.

  15. 10. European TRIGA users conference. Papers and abstracts

    International Nuclear Information System (INIS)

    1988-01-01

    The Tenth European TRIGA Users Conference was held in Vienna, September 14-16, 1988 under the sponsorship of the Atominstitut. The main areas of discussions were: Reactor operation and maintenance experiences; New developments and improvements of TRIGA components and systems, including instrumentation; Fuel and fuel management; Safety aspects, licensing and radiation protection; Experiments with TRIGA reactors; Radiochemistry, radioisotope production and NAA; and Reactor physics

  16. Organizing of medical ensurance of human population under extreme conditions. Summaries of reports of scientific-practical conference

    International Nuclear Information System (INIS)

    1994-01-01

    Summary of reports are presented of Scientific-Practical conference on the organizing of medical ensurance of human population under extreme conditions including radiation accidents. The conference held in Moscow in October, 1994. It covered problems of organizing medical ensurance of population, medical surveillance problems, sanitary-hygienic and epidemiological problems (including radiation protection), and medical provision problems under extreme conditions

  17. The third conference on nuclear science and engineering in Australia, 1999. Conference handbook

    International Nuclear Information System (INIS)

    1999-01-01

    The Australian Nuclear Association has organised this third Conference in a biennial series with the theme: 'A Nuclear Renaissance'. The theme is based on our perception that nuclear science and technology is on the threshold of a major expansion after a period which many thought was the onset of the Dark Ages after the old Australian Atomic Energy Commission was abolished in 1987. Fortunately, nuclear science and technology was not abolished and the AAEC was replaced by the government with ANSTO, which the government has continued to support strongly. The most recent expression of this support has been the approval of nearly $300 millions in investment in a major Replacement Research Reactor to be operational in about 2005, and the establishment of the new regulatory body ARPANSA. The conference aims to review all of the major nuclear issues of importance to Australia as we enter the 21st Century. These include: uranium mining and upgrading; the management of nuclear waste; the plans for the future by the government's major nuclear research laboratory, operated by ANSTO, including plans for constructing a major Replacement Research Reactor at Lucas Heights, the status of safeguards and nuclear regulation in Australia now that the government has set up the Australian Radiation Protection and Nuclear Safety Agency, and the many and varied applications of nuclear science in Australia. The conference also presents the plans for nuclear research by the universities through the Australian Institute of Nuclear Science and Engineering, and features in particular the work at the Australian National University in Canberra

  18. The third conference on nuclear science and engineering in Australia, 1999. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The Australian Nuclear Association has organised this third Conference in a biennial series with the theme: 'A Nuclear Renaissance'. The theme is based on our perception that nuclear science and technology is on the threshold of a major expansion after a period which many thought was the onset of the Dark Ages after the old Australian Atomic Energy Commission was abolished in 1987. Fortunately, nuclear science and technology was not abolished and the AAEC was replaced by the government with ANSTO, which the government has continued to support strongly. The most recent expression of this support has been the approval of nearly $300 millions in investment in a major Replacement Research Reactor to be operational in about 2005, and the establishment of the new regulatory body ARPANSA. The conference aims to review all of the major nuclear issues of importance to Australia as we enter the 21st Century. These include: uranium mining and upgrading; the management of nuclear waste; the plans for the future by the government's major nuclear research laboratory, operated by ANSTO, including plans for constructing a major Replacement Research Reactor at Lucas Heights, the status of safeguards and nuclear regulation in Australia now that the government has set up the Australian Radiation Protection and Nuclear Safety Agency, and the many and varied applications of nuclear science in Australia. The conference also presents the plans for nuclear research by the universities through the Australian Institute of Nuclear Science and Engineering, and features in particular the work at the Australian National University in Canberra.

  19. Radiation protection for humans and environment. 50 years competence in the professional association

    International Nuclear Information System (INIS)

    Bucher, Benno; Wilhelm, Christoph

    2016-01-01

    The conference proceedings of the IRPA (International radiation protection association) annual meeting 2016 contain the contribution of invited referents, other contributions and poster contributions concerning radiation protection in nuclear facilities, radiation protection of the public and environment, radioactive waste management, uranium mining, environmental monitoring, natural radioactivity, and radiation protection laws and regulations.

  20. Computational Biology Support: RECOMB Conference Series (Conference Support)

    Energy Technology Data Exchange (ETDEWEB)

    Michael Waterman

    2006-06-15

    This funding was support for student and postdoctoral attendance at the Annual Recomb Conference from 2001 to 2005. The RECOMB Conference series was founded in 1997 to provide a scientific forum for theoretical advances in computational biology and their applications in molecular biology and medicine. The conference series aims at attracting research contributions in all areas of computational molecular biology. Typical, but not exclusive, the topics of interest are: Genomics, Molecular sequence analysis, Recognition of genes and regulatory elements, Molecular evolution, Protein structure, Structural genomics, Gene Expression, Gene Networks, Drug Design, Combinatorial libraries, Computational proteomics, and Structural and functional genomics. The origins of the conference came from the mathematical and computational side of the field, and there remains to be a certain focus on computational advances. However, the effective use of computational techniques to biological innovation is also an important aspect of the conference. The conference had a growing number of attendees, topping 300 in recent years and often exceeding 500. The conference program includes between 30 and 40 contributed papers, that are selected by a international program committee with around 30 experts during a rigorous review process rivaling the editorial procedure for top-rate scientific journals. In previous years papers selection has been made from up to 130--200 submissions from well over a dozen countries. 10-page extended abstracts of the contributed papers are collected in a volume published by ACM Press and Springer, and are available at the conference. Full versions of a selection of the papers are published annually in a special issue of the Journal of Computational Biology devoted to the RECOMB Conference. A further point in the program is a lively poster session. From 120-300 posters have been presented each year at RECOMB 2000. One of the highlights of each RECOMB conference is a

  1. PKCη confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells

    International Nuclear Information System (INIS)

    Rotem-Dai, Noa; Oberkovitz, Galia; Abu-Ghanem, Sara; Livneh, Etta

    2009-01-01

    Apoptosis is frequently regulated by different protein kinases including protein kinase C family enzymes. Both inhibitory and stimulatory effects were demonstrated for several of the different PKC isoforms. Here we show that the novel PKC isoform, PKCη, confers protection against apoptosis induced by the DNA damaging agents, UVC irradiation and the anti-cancer drug - Camptothecin, of the breast epithelial adenocarcinoma MCF-7 cells. The induced expression of PKCη in MCF-7 cells, under the control of the tetracycline-responsive promoter, resulted in increased cell survival and inhibition of cleavage of the apoptotic marker PARP-1. Activation of caspase-7 and 9 and the release of cytochrome c were also inhibited by the inducible expression of PKCη. Furthermore, JNK activity, required for apoptosis in MCF-7, as indicated by the inhibition of both caspase-7 cleavage and cytochrome c release from the mitochondria in the presence of the JNK inhibitor SP600125, was also suppressed by PKCη expression. Hence, in contrast to most PKC isoforms enhancing JNK activation, our studies show that PKCη is an anti-apoptotic protein, acting as a negative regulator of JNK activity. Thus, PKCη could represent a target for intervention aimed to reduce resistance to anti-cancer treatments.

  2. 12. International conference on thin films (ICTF 12). Book of Abstract

    International Nuclear Information System (INIS)

    Majkova, E.

    2002-09-01

    The publication has been set up as a proceedings of the conference dealing with thin films production and study of their properties. The conference was focused on the following topics: (1) Advanced deposition techniques; (2) Thin Film Growth; (3) Diagnostics, Structure - Properties Relationship; (4) Mechanical Properties and Stress; (5) Protective and Functional Coatings; (6) Micropatterning and Nanostructures; (7) EUV and Soft X-Ray Multilayers; (8) Magnetic Thin Films and Multilayers; (9) Organic Thin Films; (10) Thin Films for Electronics and Optics. In this proceedings totally 157 abstracts are published of which 126 are interest for INIS

  3. The fifth conference on nuclear science and engineering in Australia, 2003. Conference handbook

    International Nuclear Information System (INIS)

    2003-01-01

    The theme of the fifth Nuclear Science and Engineering in Australia conference was 'Building on 100 years of Nuclear Science and Technology'. During the six main sessions the following topics were presented: Nuclear research and progress on major nuclear facilities, including the ANSTO Research Replacement Reactor, the Australian synchrotron and irradiation facilities; Uranium and waste management; Radiation Protection and Nuclear safety; Safeguards and Security; Nuclear Power in the Asia/Pacific region and prospects for Australia. The opening address, given by Mr Peter McGauran, Minister for Science was followed by Dr Robin Batterham, Australian Chief Scientist's introductory address. Papers included in the handbook were separately indexed

  4. The fifth conference on nuclear science and engineering in Australia, 2003. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The theme of the fifth Nuclear Science and Engineering in Australia conference was 'Building on 100 years of Nuclear Science and Technology'. During the six main sessions the following topics were presented: Nuclear research and progress on major nuclear facilities, including the ANSTO Research Replacement Reactor, the Australian synchrotron and irradiation facilities; Uranium and waste management; Radiation Protection and Nuclear safety; Safeguards and Security; Nuclear Power in the Asia/Pacific region and prospects for Australia. The opening address, given by Mr Peter McGauran, Minister for Science was followed by Dr Robin Batterham, Australian Chief Scientist's introductory address. Papers included in the handbook were separately indexed.

  5. Serum Antibodies Protect against Intraperitoneal Challenge with Enterotoxigenic Escherichia coli

    Directory of Open Access Journals (Sweden)

    Xinghong Yang

    2011-01-01

    Full Text Available To assess whether anticolonization factor antigen I (CFA/I fimbriae antibodies (Abs from enterotoxigenic Escherichia coli (ETEC can protect against various routes of challenge, BALB/c mice were immunized with a live attenuated Salmonella vaccine vector expressing CFA/I fimbriae. Vaccinated mice elicited elevated systemic IgG and mucosal IgA Abs, unlike mice immunized with the empty Salmonella vector. Mice were challenged with wild-type ETEC by the oral, intranasal (i.n., and intraperitoneal (i.p. routes. Naïve mice did not succumb to oral challenge, but did to i.n. challenge, as did immunized mice; however, vaccinated mice were protected against i.p. ETEC challenge. Two intramuscular (i.m. immunizations with CFA/I fimbriae without adjuvant conferred 100% protection against i.p. ETEC challenge, while a single 30 μg dose conferred 88% protection. Bactericidal assays showed that ETEC is highly sensitive to anti-CFA/I sera. These results suggest that parenteral immunization with purified CFA/I fimbriae can induce protective Abs and may represent an alternative method to elicit protective Abs for passive immunity to ETEC.

  6. Protection conferred by a live avian metapneumovirus vaccine when co-administered with live La Sota Newcastle disease vaccine in chicks

    Directory of Open Access Journals (Sweden)

    Kannan Ganapathy

    2014-06-01

    Full Text Available This paper examines the effects on specific pathogen-free (SPF chicks when avian metapneumovirus (aMPV and Newcastle disease virus (NDV La Sota strain vaccines are co-administered. Day-old SPF chicks were divided into five groups. The first group was inoculated with sterile water (SW and the rest of the groups were inoculated with live NDV vaccine VG/GA by the oculo-oral route. At 21 days-old, the unvaccinated chicks were again inoculated with SW. The four VG/GA-vaccinated groups were further inoculated with (i SW, (ii live aMPV vaccine, (iii live NDV La Sota, or (iv combined live NDV La Sota and live aMPV, respectively. Chicks were monitored for post-vaccination reactions and oropharyngeal swabs were collected for vaccines detection. Blood samples were collected to detect aMPV ELISA and NDV haemagglutination-inhibition antibodies. Twenty-one days following the second vaccination, six chicks from each group were challenged with virulent NDV or aMPV respectively. Chicks were monitored for clinical signs and mortality and oropharyngeal swabs collected for aMPV detection. Results showed that, when challenged with a virulent aMPV, both chicks previously vaccinated with VG/GA and subsequently given aMPV vaccine singly or in combination with La Sota were equally protected against clinical signs. Chicks that were vaccinated against NDV either once with VG/GA or followed by La Sota (singly or in combination with aMPV were fully protected when challenged with velogenic NDV. We concluded that simultaneous administration of live aMPV and NDV La Sota vaccines have no adverse effects on protection conferred by either live vaccine.

  7. Nuclear instrumentation and measurement: a review based on the ANIMMA conferences

    Science.gov (United States)

    Giot, Michel; Vermeeren, Ludo; Lyoussi, Abdallah; Reynard-Carette, Christelle; Lhuillier, Christian; Mégret, Patrice; Deconinck, Frank; Gonçalves, Bruno Soares

    2017-12-01

    The ANIMMA conferences offer a unique opportunity to discover research carried out in all fields of nuclear measurements and instrumentation with applications extending from fundamental physics to fission and fusion reactors, medical imaging, environmental protection and homeland security. After four successful editions of the Conference, it was decided to prepare a review based to a large extent but not exclusively on the papers presented during the first four editions of the conference. This review is organized according to the measurement methodologies: neutronic, photonic, thermal, acoustic and optical measurements, as well as medical imaging and specific challenges linked to data acquisition and electronic hardening. The paper describes the main challenges justifying research in these different areas, and summarizes the recent progress reported. It offers researchers and engineers a way to quickly and efficiently access knowledge in highly specialized areas.

  8. Proceedings of the national conference on recent advances in animal sciences: abstracts

    International Nuclear Information System (INIS)

    2015-01-01

    Explorations in animal sciences are ultimately aimed at human/animal welfare and protecting the environment. This conference addresses the various challenges faced due to geographic, economic and demographic conditions in the areas of animal sciences. Papers relevant to INIS are indexed separately

  9. Fake news. Fake journals. Fake conferences. What we can do.

    Science.gov (United States)

    Darbyshire, Philip

    2017-12-05

    It is time to take the gloves off in the fight against predatory publishers, predatory journals and the ever-increasing number of predatory conferences. There was a time when I believed that education and awareness, coupled with some basic policy 'signals' would be enough to bring most Universities and Schools of Nursing & Midwifery to the table (Darbyshire, McKenna, Lee, & East, 2016). It is quite touching that I could still be this naive at my age. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  10. International Conference on Durability of Critical Infrastructure

    CERN Document Server

    Cherepetskaya, Elena; Pospichal, Vaclav

    2017-01-01

    This book presents the proceedings of the International Conference on Durability of Critical Infrastructure. Monitoring and Testing held in Satov, Czech Republic from 6 to 9 December 2016. It discusses the developments in the theoretical and practical aspects in the fields of Safety, Sustainability and Durability of the Critical Infrastructure. The contributions are dealing with monitoring and testing of structural and composite materials with a new methods for their using for protection and prevention of the selected objects.

  11. Conference Report: The First ATLAS.ti User Conference

    Directory of Open Access Journals (Sweden)

    Jeanine C. Evers

    2014-01-01

    Full Text Available This report on the First ATLAS.ti User Conference shares our impressions and experiences as longstanding ATLAS.ti users and trainers about the First ATLAS.ti User Conference in Berlin 2013. The origins, conceptual principles and development of the program are outlined, the conference themes discussed and experiences shared. Finally, the future of the program is discussed. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1401197

  12. Proceedings of standing conference on health and safety in the nuclear age

    International Nuclear Information System (INIS)

    1990-01-01

    From 5 to 6 December 1989 the second meeting of the Standing Conference on Health and Safety in the Nuclear Age was held in Brussels. The subject of the meeting was informing the public on improvements in emergency preparedness and nuclear accident management. The Standing Conference was created by the Commission of the European Communities in 1986 and its goal is to convey to the European public, via the mass media, factual information on nuclear subjects of current interest. About 100 experts and representatives of the mass media, competent authorities and socio-economic organizations followed the meeting, the specific objective of which was to discuss, from the point of view of radiation protection of the public and the environment, the improvements that nuclear accident management and intervention plans have undergone in recent years. Invited contributions underlined the presently improved levels of international and Community cooperation in radiation and nuclear safety, particularly in the fields of emergency preparedness and planning, where recent years have witnessed significant developments. The conference requested the Commission to pursue its public information efforts aimed at improving the understanding that the citizens of the Community have on the potential risks and the protective measures which were implemented in the nuclear sphere

  13. Professional conference of the sections WIN and RE of Slovak Nuclear Society. Collections of abstracts

    International Nuclear Information System (INIS)

    2015-04-01

    The Conference deals with problems of nuclear safety, radiation protection and monitoring of the environment, radiation therapy, separation of radioisotopes, and operation of accelerator radiation centre. Eight contributions were published.

  14. NUCLEAR 2009 international conference on sustainable development through nuclear research and education. Book of Abstracts

    International Nuclear Information System (INIS)

    Constantin, Marin; Turcu, Ilie

    2009-01-01

    The Book of abstracts of the papers submitted to 'NUCLEAR 2009 international conference on sustainable development through nuclear research and education' held at INR-Pitesti on May, 27 - 29 2009 contain 109 abstracts of the communications submitted for two plenary sessions (6 and 4 talks, respectively) and three sections addressing the themes of Nuclear energy, Environmental protection, and Sustainable development. In turn these sections are addressing the following items: Section 1.1 - Nuclear safety and severe accidents (8 papers); Section 1.2 - Nuclear reactors (15 papers); Section 1.3 - Nuclear technologies and materials (32 papers); Section 2.1 - Radioactive waste management (18 papers; Section 2.2 and Section 2.3 - Radioprotection and air, water and soil protection (12 papers); Section 3.1 - Education, continuous formation and knowledge transfer (9 papers); Section 3.2 -Strategies in energy (Round table) (5 papers). A number of 17 papers are presented only as abstracts in this book, the rest were presented fully during the conference. The proceedings of the conference are separately processed and introduced as such in the INIS database

  15. Veterans in Society Conference 2014: Humanizing the Discourse (Conference Program)

    OpenAIRE

    Virginia Tech. Department of English. Center for the Study of Rhetoric in Society; Virginia Tech. Veterans Studies Group

    2014-01-01

    This program lists the daily sessions, presentations, and events that took place during the 2014 Veterans in Society Conference, which was held from April 27-28, 2014 at the Hotel Roanoke in Roanoke, VA. This program also includes speaker and presenter bios, descriptions of unrecorded conference events, and a letter from conference co-chair Jim Dubinsky, the director of Virginia Tech's Center for the Study of Rhetoric in Society. The 2014 Veterans in Society Conference: Humanizing the Discour...

  16. INTERCARTO CONFERENCES

    Directory of Open Access Journals (Sweden)

    Vladimir Tikunov

    2010-01-01

    Full Text Available The InterCarto conferences are thematically organized to target one of the most pressing problems of modern geography—creation and use of geographical information systems (GISs as effective tools for achieving sustainable development of territories. Over the years, from 1994 to 2009, 1872 participants from 51 countries and 156 cities, who made 1494 reports, attended the conferences. There were 1508 participants from 49 regions of Russia making 1340 presentations. The conferences hosted 31 different sections, most popular of which were Environmental GIS-Projects: Development and Experience, Sustainable Development and Innovative Projects, GIS: the Theory and Methodology, Projects for Russia and Regions, and GIS-Technologies and Digital Mapping. The next annual InterCarto-InterGIS conference will take place in December 2011. The Russian component of the conference will be held in the Altay Kray followed by another meeting on Bali, Indonesia

  17. Proceedings of Alberta's environment conference 2005 : connecting and collaborating

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    Alberta's environmental management and leadership was discussed with reference to opportunities to collaborate in managing, protecting and sustaining the environment. Alberta has already made substantial achievements since it established the Environment Ministry in 1971. Achievements include Canada's first recycling programs for tires, bottles and electronics, and a climate change action plan. Currently, 90 per cent of the government's electricity needs are supplied by wind power from Pincher Creek and biomass from Grand Prairie. The conference themes for the 2005 conference were: partnering for success to support environmental management; sharing knowledge and new research results through environmental monitoring and reporting; future trends and the vision for environmental management and resource development; and, programs and policy that support environmental management. The conference featured 25 presentations, of which 5 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  18. Proceedings of AsiaPES 2007 : Asian power and energy systems conference

    Energy Technology Data Exchange (ETDEWEB)

    Ongsakul, W. [Asian Inst. of Technology, Pathumthani (Thailand)] (ed.)

    2007-07-01

    This energy and power systems conference provided a forum for international researchers and power industry members to discuss recent technological innovations related to power systems. New technologies and modelling strategies for power systems were identified along with issues related to artificial intelligence and design optimization. The role of renewable energy sources such as solar, wind and biomass energy in interconnected power systems were also reviewed. The conference was divided into 8 sessions entitled: (1) control, protection, power flow and design, (2) planning and operation, (3) alternative energy, (4) stability, reliability, forecasting and load shedding, (5) phasor measurement and power quality, (6) distribution, analysis, technology and policy (7) energy efficiency, storage and pricing, and (8) a special session on the application of phasor measurement units to monitor wide area power system dynamics. The conference featured 88 presentations, of which 63 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  19. Psidium guajava Linn confers gastro protective effects on rats.

    Science.gov (United States)

    Livingston Raja, N R; Sundar, K

    2012-02-01

    The best alternatives to synthetic medicines, available, for the treatment of gastric ulcer disorders, are the natural products found in plants. They are known to exhibit a variety of activities. The present study is aimed at the screening of Psidium (P.) guajava Linn for its gastro protective effect. The methanol extracts of the leaves of P. guajava were tested in three different ulcer models viz. aspirin (ASP), pyloric ligation (PL) and ethanol (EtoH) induced ulcer models in rats. The treatment of P. guajava at varying doses (100 mg/kg and 200 mg/kg) significantly (p guajava may be responsible for the anti-ulcer property exhibited. The results further suggest that P. guajava possess gastro protective as well as ulcer healing properties which might also be due to its anti-secretory properties.

  20. Discovering naturally processed antigenic determinants that confer protective T cell immunity

    DEFF Research Database (Denmark)

    Gilchuk, Pavlo; Spencer, Charles T; Conant, Stephanie B

    2013-01-01

    and elicited protective TCD8 immunity against lethal intranasal VACV infection. Notably, efficient processing and stable presentation of immune determinants as well as the availability of naive TCD8 precursors were sufficient to drive a multifunctional, protective TCD8 response. Our approach uses fundamental...

  1. 2nd International Conference on Dynamics of Disasters

    CERN Document Server

    Nagurney, Anna; Pardalos, Panos

    2016-01-01

    This volume results from the “Second International Conference on Dynamics of Disasters” held in Kalamata, Greece, June 29-July 2, 2015. The conference covered particular topics involved in natural and man-made disasters such as war, chemical spills, and wildfires. Papers in this volume examine the finer points of disasters through: · Critical infrastructure protection · Resiliency · Humanitarian logistic · Relief supply chains · Cooperative game theory · Dynamical systems · Decision making under risk and uncertainty · Spread of diseases · Contagion · Funding for disaster relief · Tools for emergency preparedness · Response, and risk mitigation Multi-disciplinary theories, tools, techniques and methodologies are linked with disasters from mitigation and preparedness to response and recovery. The interdisciplinary approach to problems in economics, optimization, government, management, business, humanities, engineering, medicine, mathematics, computer science, behavioral studies, emergency servi...

  2. Conference summaries. Canadian Nuclear Association 29. annual conference; Canadian Nuclear Society 10. annual conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-12-31

    Separate abstracts were prepared for 15 papers from the twenty-ninth Annual Conference of the Canadian Nuclear Association. Abstracts were also prepared for the 102 papers from the tenth Annual Conference of the Canadian Nuclear Society.

  3. Conference summaries. Canadian Nuclear Association 29. annual conference; Canadian Nuclear Society 10. annual conference

    International Nuclear Information System (INIS)

    1989-01-01

    Separate abstracts were prepared for 15 papers from the twenty-ninth Annual Conference of the Canadian Nuclear Association. Abstracts were also prepared for the 102 papers from the tenth Annual Conference of the Canadian Nuclear Society

  4. Consumer Protection in Postsecondary Education: A National Invitational Conference. Program Handbook.

    Science.gov (United States)

    Albanese, Frank N.; And Others

    Twelve preconference papers and background articles that identify issues in consumer protection in postsecondary education are presented. The papers and articles include "Recruitment Practices of Postsecondary Schools" (Frank N. Albanese); "The Role of a State Agency in Consumer Protection" (Philip F. Ashler); "The Three R's of Postsecondary…

  5. 20th IAEA fusion energy conference 2004. Conference proceedings

    International Nuclear Information System (INIS)

    2005-01-01

    The 20th International Atomic Energy Agency (IAEA) Fusion Energy Conference (FEC) was held in Vilamoura, Portugal, from 1 to 6 November 2004. The Instituto Superior Tecnico through the Centro de Fusao Nuclear on behalf of the Portuguese Government and the Association EURATOM/IST hosted the conference. The IAEA wishes to express its gratitude to the host. More than 600 delegates representing 33 countries and three international organizations attended the Fusion Energy Conference 2004. The Programme Committee accepted a total of some 437 papers for presentation at the conference. The scientific experimental and theoretical papers have been grouped with respect to the following themes: Overview on magnetic and inertial fusion; Advanced Scenarios and Steady State; Edge Localized Modes; Fusion Technology; Transport Theory; Beta Limits; Hybrid Scenarios; H-mode and Transport; ITER; Alfven Modes and Wave Heating; Operational Limits and Momentum Transport; Energetic Particles and Stability; Neoclassical Tearing Modes; Transport and Turbulence; Inertial Fusion; Configuration Effects and Transport; and Plasma-wall Interaction. The conference adjourned with the announcement of the next IAEA Fusion Energy Conference, which will be held for the first time in the People's Republic of China, in the city of Chengdu, October 16-22, 2006

  6. 2008 Gordon Research Conference on Catalysis [Conference summary report

    Energy Technology Data Exchange (ETDEWEB)

    Soled, Stuart L.; Gray, Nancy Ryan

    2009-01-01

    The GRC on Catalysis is one of the most prestigious catalysis conferences as it brings together leading researchers from around the world to discuss their latest, most exciting work in catalysis. The 2008 conference will continue this tradition. The conference will cover a variety of themes including new catalytic materials, theoretical and experimental approaches to improve understanding of kinetics and transport phenomena, and state of the art nanoscale characterization probes to monitor active sites. The conference promotes interactions among established researchers and young scientists. It provides a venue for students to meet, talk to and learn from some of the world leading researchers in the area. It also gives them a platform for displaying their own work during the poster sessions. The informal nature of the meeting, excellent quality of the presentations and posters, and ability to meet many outstanding colleagues makes this an excellent conference.

  7. Setting the agenda in emergency medicine in the southern African region: Conference assumptions and recommendations, Emergency Medicine Conference 2014: Gaborone, Botswana

    Directory of Open Access Journals (Sweden)

    Lloyd D. Christopher

    2014-09-01

    Full Text Available The first international emergency medicine (EM conference in Botswana was held on 15th and 16th May 2014 at the Gaborone International Convention Centre. The support from key stakeholders positioned the conference, from its conception, to deliver expert guidance on emergency medicine relevance, education and systems implementation. The conference theme was aptly: “Setting the Agenda in Emergency Medicine in the Southern African Region.” Over 300 local, regional and international delegates convened to participate in this landmark event. Country representation included Botswana, South Africa, Zambia, Namibia, Zimbabwe, Swaziland, Lesotho, Nigeria and the United States of America. Conference assumptions intersected emergency care, African burden of injury and illness and the role of the state; the public protection ethic of emergency care, and the developmental, economic and health interest in promoting EM. The recommendations addressed emergency care relevance; health systems research as an imperative for emergency systems development in southern Africa; community agency as a requisite for emergency care resilience; emergency care workers as pivotal to the emergency medical system, and support of EM system implementation. The conference recommendations – by way of setting an agenda, augur well for emergency care development and implementation in the southern African region and are likely to prove useful to the southern African countries seeking to address health service quality, EM advocacy support and implementation guidance. Emergency medicine is the only discipline with ‘universality’ and ‘responsivity’ at the point of need. This implies the widespread potential for facilitation of access to health care: a public health goal nuanced by the African development agenda.

  8. Proceedings of the Radiation protection supervisors' day of November 7, 2013

    International Nuclear Information System (INIS)

    Langlet, Jean; Piferrer, Jean-Paul; Morin, Catherine; Lefaure, Christian; Tourneux, Christophe; CONAN, Nadine; MARC, Benoit; Etard, Cecile; Rehel, J.L.; Aubert, B.; Ranouil, Julien

    2013-11-01

    Organised by the Association for radioprotection Techniques and Sciences (ATSR) and sponsored by the Commission of external radiation protection supervisors, this radiation protection supervisors' day was the occasion to take stock of the regulation, of the recurrent problems and advances in radiation protection. The conference brought together 9 presentations dealing with: 1 - Works of the Commission of external radiation protection supervisors (J.P. Piferrer); 2 - National and European regulation updates (T. Lahaye); 3 - Problems relating to control equipments (J. Langlet); 4 - Problems relating to the professional insurance for external radiation protection supervisors: national consultation by the ATSR (key points for the development of a national multidisciplinary consultative meeting by the ATSR, C. Morin); 5 - Situation of radiation protection supervisor networks (C. Lefaure, C. Tourneux); 6 - RPE-RPA-RSSO functions at CERN: creation and experience feedback (Experience feedback of the implementation of the RPE/RPO(A) European regulation at CERN, N. Conan); 7 - Industry: PCR n + Σ TQRP = SRP* (B. Marc); 8 - Interventional radiology: lessons to be learnt from recent overexposure incidents? (Medicine: protection supervisor and interventional radiology, C. Etard, J.L. Rehel, B. Aubert); 9 - GEDOC: research group on eye lens dosimetry (Eye lens exposure to ionizing radiations, J. Ranouil). This document brings together the presentations (slides) presented during the conference

  9. Abstracts of the 15. annual MDEC conference

    International Nuclear Information System (INIS)

    2009-01-01

    The Mining Diesel Emissions Council (MDEC) conducts annual meetings dedicated to the improvement of air quality in underground mines and protection of diesel operators. The MDEC promotes awareness of suppliers who bring clean air solutions to the mining industry through the development and use of new diesel technologies or the use of biodiesel fuels. This conference focused on underground air quality issues with particular reference to the use of diesel powered equipment and associated exhaust emissions. The presentations addressed topical issues such as worker exposure limits to diesel particulate matter (DPM); diesel particulate filters (DPFs) in mine ventilation systems and also in diesel engines; and, the use of alternative fuels such as biodiesel. The sessions were entitled: biodiesel; control technologies; ambient DPM; diesel and MDEC plenary consultation; engines and emissions; DPM and ventilation; and MDEC 2008 roundtable forum review panel. The conference featured 17 presentations, of which 8 have been catalogued separately for inclusion in this database

  10. Proceedings of the international conference on environment and energy: souvenir

    International Nuclear Information System (INIS)

    2014-01-01

    The theme of the conference has great relevance to address various emerging Environmental and Energy issues under growing economies of developing countries like India. Energy consumption and environmental protection go hand-in-hand, and pollution problems posed by the use of fossil fuels are major concern throughout world. Global consensus has now emerged on the need for implementation of radical technological and structural changes on both the generation and energy usage sectors in-order to protect the environment even as we maintain economic growth where renewable and clean energy technologies are expected to play vital role. Papers relevant to INIS are indexed separately

  11. European Research Reactor Conference (RRFM) 2015: Conference Proceedings

    International Nuclear Information System (INIS)

    2015-01-01

    In 2015 the European Research Reactor Conference, RRFM, took place in Bucharest, Romania. The conference programme resolved around a series of plenary sessions dedicated to the latest global developments with regards to research reactor technology and management. Parallel sessions focused on all areas of the fuel cycle of research reactors, their utilisation, operation and management as well as new research reactor projects and Innovative methods in reactor physics and thermo-hydraulics. The European Research Reactor Conference also gave special attention to safety and security of research reactors

  12. European Research Reactor Conference (RRFM) 2016: Conference Proceedings

    International Nuclear Information System (INIS)

    2016-01-01

    The 2016 European Research Reactor Conference, RRFM, took place in Berlin, Germany. The conference programme resolved around a series of plenary sessions dedicated to the latest global developments with regards to research reactor technology and management. Parallel sessions focused on all areas of the fuel cycle of research reactors, their utilisation, operation and management as well as new research reactor projects and Innovative methods in reactor physics and thermo-hydraulics. The European Research Reactor Conference also gave special attention to safety and security of research reactors.

  13. Proceedings of the 1991 national conference on hydraulic engineering

    International Nuclear Information System (INIS)

    Shane, R.M.

    1991-01-01

    This book contains the proceedings of the 1991 National Conference of Hydraulic Engineering. The conference was held in conjunction with the International Symposium on Ground Water and a Software Exchange that facilitated exchange of information on recent software developments of interest to hydraulic engineers. Also included in the program were three mini-symposia on the Exclusive Economic Zone, Data Acquisition, and Appropriate Technology. Topics include sedimentation; appropriate technology; exclusive economic zone hydraulics; hydraulic data acquisition and display; innovative hydraulic structures and water quality applications of hydraulic research, including the hydraulics of aerating turbines; wetlands; hydraulic and hydrologic extremes; highway drainage; overtopping protection of dams; spillway design; coastal and estuarine hydraulics; scale models; computation hydraulics; GIS and expert system applications; watershed response to rainfall; probabilistic approaches; and flood control investigations

  14. Conference summaries

    International Nuclear Information System (INIS)

    1991-01-01

    This volume contains conference summaries for the 31. annual conference of the Canadian Nuclear Association and the 12. annual conference of the Canadian Nuclear Society. Topics of discussion include: reactor physics; thermalhydraulics; industrial irradiation; computer applications; fuel channel analysis; small reactors; severe accidents; fuel behaviour under accident conditions; reactor components, safety related computer software; nuclear fuel management; fuel behaviour and performance; reactor safety; reactor engineering; nuclear waste management; and, uranium mining and processing

  15. INTERCARTO CONFERENCES

    OpenAIRE

    Vladimir Tikunov

    2010-01-01

    The InterCarto conferences are thematically organized to target one of the most pressing problems of modern geography—creation and use of geographical information systems (GISs) as effective tools for achieving sustainable development of territories. Over the years, from 1994 to 2009, 1872 participants from 51 countries and 156 cities, who made 1494 reports, attended the conferences. There were 1508 participants from 49 regions of Russia making 1340 presentations. The conferences hosted 31 di...

  16. Vancouver AIDS conference: special report. The role of the military: to protect society -- and themselves.

    Science.gov (United States)

    Whiteside, A; Winsbury, R

    1996-01-01

    Military personnel are at particularly high risk of becoming infected with HIV because they are in the age group at highest risk for infection, age 15-24 years; they are away from home for long periods of time; many feel invulnerable and ready to take risks; there are usually prostitutes and drugs in military areas; and troops have cash, but maybe not condoms, in their pockets. The level of attention given to HIV/AIDS in the military has grown over the course of the last few international AIDS conferences. One roundtable on HIV/AIDS in the armed forces was held at the 11th International Conference on AIDS held in Vancouver during July 7-12, 1996. A large-scale survey reported at the conference found the level of sexual activity to be significantly higher among US military personnel than in the civilian population. Even the oldest soldiers reported higher levels of multiple partner sex habits than the most sexually active young men in the UK and France. The data further indicate that significant numbers of those men who were infected continued to knowingly have unprotected sex. Data from Angola, Cambodia, Cameroon, the Central African Republic, Congo, Cote d'Ivoire, Thailand, and Zimbabwe show significantly higher levels of HIV infection among military personnel compared to the civilian populations. The authors stress the important role the military can play in preventing the spread of HIV and the need to involve military personnel in AIDS prevention programs.

  17. Proceedings of the 4. IASTED Asian conference on power and energy systems : AsiaPES 2008

    Energy Technology Data Exchange (ETDEWEB)

    Nor, K.M. [Technological Univ. of Malaysia, Kuala Lumpur (Malaysia)] (ed.)

    2008-07-01

    Recent technological innovations related to power systems were presented at this international energy and power systems conference. New technologies and modelling strategies for power systems were identified along with issues related to artificial intelligence and design optimization. The role of renewable energy sources such as solar, wind and biomass energy in interconnected power systems were also reviewed. The conference was divided into 9 sessions entitled: (1) distribution systems, (2) electromagnetic fields, (3) power quality, (4) power system operations, (5) power system planning, (6) power system protection, (7) power system stability, (8) renewable energy, and (9); thermal systems. All 68 presentations from the conference have been catalogued separately for inclusion in this database. refs., tabs., figs.

  18. Strategies, Research Priorities, and Partnerships for Community IPM to Prevent Tick-Borne Diseases--2011 Conference

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) held the Promoting Community Integrated Pest Management to Prevent Tick-Borne Diseases Conference on March 30th and 31st, 2011 in Arlington, Virginia. Read the meeting summary.

  19. Proceedings of the third international conference on CANDU maintenance

    International Nuclear Information System (INIS)

    1995-01-01

    The third international conference on Candu maintenance included sessions on the following topics: predictive maintenance, reliability improvements, steam generator monitoring, tools and instrumentation, valve performance, fuel channel inspection and maintenance, steam generator maintenance, environmental qualification, predictive maintenance, instrumentation and control, steam generator cleaning, decontamination and radiation protection, inspection techniques, maintenance program strategies and valve packing experience, remote tooling/ robotics and fuel handling. The individual papers have been abstracted separately

  20. Proceedings of the third international conference on CANDU maintenance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The third international conference on Candu maintenance included sessions on the following topics: predictive maintenance, reliability improvements, steam generator monitoring, tools and instrumentation, valve performance, fuel channel inspection and maintenance, steam generator maintenance, environmental qualification, predictive maintenance, instrumentation and control, steam generator cleaning, decontamination and radiation protection, inspection techniques, maintenance program strategies and valve packing experience, remote tooling/ robotics and fuel handling. The individual papers have been abstracted separately.

  1. Proceedings of the 1989 Carnahan conference on security technology

    International Nuclear Information System (INIS)

    DeVore, R.W.

    1989-01-01

    This book contains the proceedings of the 1989 Carnahan conference on security technology and crime countermeasures. Topics covered include: study of methods for the enhancement of classified document control and protection; research and development of a portable microfocus x-ray system capable of providing ultra-high resolution images of improvised explosive devices; and BombCAD - a CAD-based technique for assessing bomb vulnerability and designing and evaluating bomb defense measures

  2. Conference Support, 23rd Western Photosynthesis Conference 2014, Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, Rebekka [Arizona State Univ., Tempe, AZ (United States)

    2015-01-12

    The Western Photosynthesis Conference is a regional conference that is held on an annual basis to bring together researchers primarily from the Western United States to share their newest research advances on photosynthetic processes. The 23rd conference was focused on both fundamental and more applied research on the biological conversion of solar energy to various energy storage forms. Several particular areas of solar energy conversion were emphasized in this conference (see below). Some of these topics, such as carbon limitations on photosynthesis, biomimicry and phenotyping, have traditionally not been incorporated extensively in the Western Photosynthesis Conference. We found that these topics have substantially broadened of the scope of this meeting.

  3. 78 FR 27963 - Reliability Technical Conference; Notice of Technical Conference

    Science.gov (United States)

    2013-05-13

    ... Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, July 9, 2013 from 9:00 a.m. to 5:00 p.m. This... technical support for webcasts and offers the option of listening to the meeting via phone-bridge for a fee...

  4. L-032: EPR-First responders: Guidelines for public protection

    International Nuclear Information System (INIS)

    2011-01-01

    This conference is about the guidelines to public protection in a radiological emergency. The responsible for promoting clear instructions will be the commander of incident directed to the public inside and outside of the security cordon.

  5. Conference on medical physics and biomedical engineering

    International Nuclear Information System (INIS)

    2013-01-01

    Due to the rapid technological development in the world today, the role of physics in modern medicine is of great importance. The frequent use of equipment that produces ionizing radiation further increases the need for radiation protection, complicated equipment requires technical support, the diagnostic and therapeutic methods impose the highest professionals in the field of medical physics. Thus, medical physics and biomedical engineering have become an inseparable part of everyday medical practice. There are a certain number of highly qualified and dedicated professionals in medical physics in Macedonia who committed themselves to work towards resolving medical physics issues. In 2000 they established the first and still only professional Association for Medical Physics and Biomedical Engineering (AMPBE) in Macedonia; a one competent to cope with problems in the fields of medicine, which applies methods of physics and biomedical engineering to medical procedures in order to develop tools essential to the physicians that will ultimately lead to improve the quality of medical practice in general. The First National Conference on Medical Physics and Biomedical Engineering was organized by the AMPBE in 2007. The idea was to gather all the professionals working in medical physics and biomedical engineering in one place in order to present their work and increase the collaboration among them. Other involved professions such as medical doctors, radiation technologists, engineers and professors of physics at the University also took part and contributed to the success of the conference. As a result, the Proceedings were published in Macedonian, with summaries in English. In order to further promote the medical physics amongst the scientific community in Macedonia, our society decided to organize The Second Conference on Medical Physics and Biomedical Engineering in November 2010. Unlike the first, this one was with international participation. This was very suitable

  6. Cairo conference.

    Science.gov (United States)

    McMichael, A J

    1994-09-03

    The United Nations Conference on Population and Development in Cairo in September, 1994, will evoke criticism of the inability of governments to act quickly enough to avert demographic and environmental crises. Rapid population growth has clear implications for public health. Globally there now occur anthropogenic changes in atmospheric composition, the degradation of fertile lands and ocean fisheries, an accelerating loss of biodiversity, and the social and ecological problems of massive urbanization. In the future, per capita consumption levels will increase in burgeoning populations of developing countries, thus adding to the environmental impacts of overconsuming rich countries. By the end of the decade there will be over six billion people, of whom one half will live in cities. These demographic and environmental trends, if translated into climatic change, regional food shortages, and weakened ecosystems, would adversely affect human health. The World Health Organization is likely to concentrate only on accessible family planning and promotion of health for women and families. Continuing asymmetric child-saving aid, unaccompanied by substantial aid to help mobilize the social and economic resources needed to reduce fertility, may delay the demographic transition in poor countries and potentiate future public health disasters. As a result of recent reductions in fertility, even in Sub-Saharan Africa, average family sizes have been halved. Yet the demographic momentum will double population by 2050. The biosphere is a complex of ecosystems and, if unsustained, it could not fulfill the productive, cleansing, and protective functions on which life depends. The Cairo conference must therefore recognize that sustaining human health is a prime reason for concern about population growth and models of economic development.

  7. COAL Conference Poster

    OpenAIRE

    Brown, Taylor Alexander; McGibbney, Lewis John

    2017-01-01

    COAL Conference Poster This archive contains the COAL conference poster for the AGU Fall Meeting 2017 by Taylor Alexander Brown. The Inkscape SVG source is available at https://github.com/capstone-coal/coal-conference-poster/ under the Creative Commons Attribution-ShareAlike 4.0 International license.

  8. Abstracts of the Canadian Society for Civil Engineering annual conference including the general conference, the 1. international structural specialty conference, the 1. international construction specialty conference, and the 1. specialty conference on disaster mitigation : towards a sustainable future

    International Nuclear Information System (INIS)

    El-Badry, M.; Loov, R.E.; Ruwanpura, J.; El-Hacha, R.; Kroman, J.; Rankin, J.

    2006-01-01

    This conference provided a forum for national and international practicing engineers, researchers and technical experts to discuss sustainable solutions to infrastructure development. Discussions focused on recent developments in new technologies for building more economic and sustainable infrastructure, while improving the safety of buildings, bridges, roads, water supply and sewage treatment systems. The conference was held in conjunction with associated specialty conferences, including a first international structures specialty conference, a first international construction specialty conference, and a first specialty conference on disaster mitigation. This book of abstracts highlights all the specialty conferences and accompanies a CD-ROM that has the full text of all the papers. Manuscripts of the full papers submitted to the specialty conferences were peer-reviewed by international scientific committees. The general conference provided a forum to learn about new technologies and future directions in various areas of civil engineering. It included a special theme session on sustainable development and a special session on innovation and information technology. Other technical sessions focused on topics such as civil engineering history and education; infrastructure management and renewal; asset management; risk assessment and management; engineering materials and mechanics; environmental engineering and science; hydrotechnical engineering; cold region engineering; and, transportation engineering. The general conference featured 88 presentations, of which 15 have been catalogued separately for inclusion in this database

  9. Protective Immunity and Reduced Renal Colonization Induced by Vaccines Containing Recombinant Leptospira interrogans Outer Membrane Proteins and Flagellin Adjuvant

    Science.gov (United States)

    Monaris, D.; Sbrogio-Almeida, M. E.; Dib, C. C.; Canhamero, T. A.; Souza, G. O.; Vasconcellos, S. A.; Ferreira, L. C. S.

    2015-01-01

    Leptospirosis is a global zoonotic disease caused by different Leptospira species, such as Leptospira interrogans, that colonize the renal tubules of wild and domestic animals. Thus far, attempts to develop effective leptospirosis vaccines, both for humans and animals, have failed to induce immune responses capable of conferring protection and simultaneously preventing renal colonization. In this study, we evaluated the protective immunity induced by subunit vaccines containing seven different recombinant Leptospira interrogans outer membrane proteins, including the carboxy-terminal portion of the immunoglobulinlike protein A (LigAC) and six novel antigens, combined with aluminum hydroxide (alum) or Salmonella flagellin (FliC) as adjuvants. Hamsters vaccinated with the different formulations elicited high antigen-specific antibody titers. Immunization with LigAC, either with alum or flagellin, conferred protective immunity but did not prevent renal colonization. Similarly, animals immunized with LigAC or LigAC coadministered with six leptospiral proteins with alum adjuvant conferred protection but did not reduce renal colonization. In contrast, immunizing animals with the pool of seven antigens in combination with flagellin conferred protection and significantly reduced renal colonization by the pathogen. The present study emphasizes the relevance of antigen composition and added adjuvant in the efficacy of antileptospirosis subunit vaccines and shows the complex relationship between immune responses and renal colonization by the pathogen. PMID:26108285

  10. Erosion protection conferred by whole human saliva, dialysed saliva, and artificial saliva

    Science.gov (United States)

    Baumann, T.; Kozik, J.; Lussi, A.; Carvalho, T. S.

    2016-10-01

    During dental erosion, tooth minerals are dissolved, leading to a softening of the surface and consequently to irreversible surface loss. Components from human saliva form a pellicle on the tooth surface, providing some protection against erosion. To assess the effect of different components and compositions of saliva on the protective potential of the pellicle against enamel erosion, we prepared four different kinds of saliva: human whole stimulated saliva (HS), artificial saliva containing only ions (AS), human saliva dialysed against artificial saliva, containing salivary proteins and ions (HS/AS), and human saliva dialysed against deionised water, containing only salivary proteins but no ions (HS/DW). Enamel specimens underwent four cycles of immersion in either HS, AS, HS/AS, HS/DW, or a humid chamber (Ctrl), followed by erosion with citric acid. During the cycling process, the surface hardness and the calcium released from the surface of the specimens were measured. The different kinds of saliva provided different levels of protection, HS/DW exhibiting significantly better protection than all the other groups (p < 0.0001). Different components of saliva, therefore, have different effects on the protective properties of the pellicle and the right proportions of these components in saliva are critical for the ability to form a protective pellicle.

  11. Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

    Science.gov (United States)

    Goszcz, Katarzyna; Deakin, Sherine J.; Duthie, Garry G.; Stewart, Derek

    2017-01-01

    Despite limited bioavailability and rapid degradation, dietary anthocyanins are antioxidants with cardiovascular benefits. This study tested the hypothesis that the antioxidant protection conferred by the anthocyanin, delphinidin, is mediated by modulation of endogenous antioxidant defences, driven by its degradation product, gallic acid. Delphinidin was found to degrade rapidly (t1/2 ~ 30 min), generating gallic acid as a major degradation product. Both delphinidin and gallic acid generated oxygen-centred radicals at high (100 μM) concentrations in vitro. In a cultured human umbilical vein endothelial cell model of oxidative stress, the antioxidant protective effects of both delphinidin and gallic acid displayed a hormesic profile; 100 μM concentrations of both were cytotoxic, but relatively low concentrations (100 nM–1 μM) protected the cells and were associated with increased intracellular glutathione. We conclude that delphinidin is intrinsically unstable and unlikely to confer any direct antioxidant activity in vivo yet it offered antioxidant protection to cells at low concentrations. This paradox might be explained by the ability of the degradation product, gallic acid, to confer benefit. The findings are important in understanding the mode of protection conferred by anthocyanins and reinforce the necessity to conduct in vitro experiments at biologically relevant concentrations. PMID:29081896

  12. Proceedings of the 1. Arabic conference on chemical applications (Chemia 2). Vol. 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The 1. Arabic conference on chemical applications was held on 1-5 Nov 1997 in Cairo. The specialists discussed the chemical applications for environmental service. This first volume covers papers presented on the subjects environmental protection of pollution, nuclear materials and environment, nuclear materials and industry.

  13. Proceedings of the 1. Arabic conference on chemical applications (Chemia 2). Vol. 1

    International Nuclear Information System (INIS)

    1997-11-01

    The 1. Arabic conference on chemical applications was held on 1-5 Nov 1997 in Cairo. The specialists discussed the chemical applications for environmental service. This first volume covers papers presented on the subjects environmental protection of pollution, nuclear materials and environment, nuclear materials and industry

  14. National Physics Conference, CNF 2001, Iasi. Abstracts

    International Nuclear Information System (INIS)

    Rusu, George; Caltun, Ovidiu

    2001-01-01

    The National Physics Conference, organized by Romanian Physics Society, was held on October 18-20, 2001 in Iasi, Romania. There were 8 sections as follows: Theoretical and Computational Physics; Magnetism and Magnetic Materials; Condensed Matter Physics and Technical Physics; Plasma Physics; Atomic and Nuclear Physics; Optics and Quantum Electronics; Physics and Education; Biophysics, Earth and Environment Physics. The papers accepted as being of INIS interest were mainly in the fields of Plasma Fusion, High Energy and Nuclear Physics, Instrumentation Related to Nuclear Science, Radiation Protection, Isotope Production and Materials Science

  15. Post graduate course of radiation protection. V. 1-2

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1991, the General Conference of IAEA, in the resolution GC/XXXV/RES/552 demanded the Director General to formulate the propositions in the field of education and teaching of radiation protection. After its meeting in 1993, the General Conference (document GC/XXXVII/1067) a program of education in radiation protection and nuclear safety. The IAEA has chosen L'Instut national des science et techniques nucleaires (INSTN) de Saclay, France, to perform the french training for its long-term education in nuclear field. During the nine weeks in May and June 1994, 24 participants from 22 countries attended 80 courses presented by 70 teachers. The organizers have attained a successful cooperation of competent French organizations in the field of radiation protection and nuclear safety as: Institut de protection et de surete nucleaire (IPSN), Commissariat a l'energie atomique (CEA), Compagnie generales des matieres nucleaires (COGEMA), Agence nationale pour la gestion de dechets radioactif (ANDRA), Office de protection contre les raynnements ionisants (OPRI), Electicite de France (EDF), as well as outstanding specialists in the medical field. The series of these lectures are presented in these two volumes. Admitting that the education and training in the field of radiation protection and nuclear safety are responsibilities of national authorities the IAEA hopes that this published material would be widely used by the Member States as a basis for their training programs in the mentioned field

  16. International Conference on Physics

    CERN Document Server

    2016-01-01

    OMICS International, (conference series) the World Class Open Access Publisher and Scientific Event Organizer is hosting “International Conference on physics” which is going to be the biggest conference dedicated to Physics. The theme “Highlighting innovations and challenges in the field of Physics” and it features a three day conference addressing the major breakthroughs, challenges and the solutions adopted. The conference will be held during June 27-29, 2016 at New Orleans, USA. Will be published in: http://physics.conferenceseries.com/

  17. Facilitating Learning at Conferences

    DEFF Research Database (Denmark)

    Ravn, Ib; Elsborg, Steen

    2011-01-01

    The typical conference consists of a series of PowerPoint presentations that tend to render participants passive. Students of learning have long abandoned the transfer model that underlies such one-way communication. We propose an al-ternative theory of conferences that sees them as a forum...... for learning, mutual inspiration and human flourishing. We offer five design principles that specify how conferences may engage participants more and hence increase their learning. In the research-and-development effort reported here, our team collaborated with conference organizers in Denmark to introduce...... and facilitate a variety of simple learning techniques at thirty one- and two-day conferences of up to 300 participants each. We present ten of these techniques and data evaluating them. We conclude that if conference organizers allocate a fraction of the total conference time to facilitated processes...

  18. Second meeting of competent persons in radiation protection

    International Nuclear Information System (INIS)

    2000-01-01

    This conference treats the subjects interesting the competent persons in radiation protection. It is divided in four sessions. The first one concerns the regulatory bases for the action of competent persons and includes three articles, the second one is about the operational dosimetry and includes six articles, the third session is devoted to the sources and waste management and represents two texts, the last and fourth session concerns the competent person in radiation protection and gives evidence. (N.C.)

  19. World Energy Conference

    International Nuclear Information System (INIS)

    Ott, G.; Schilling, H.D.

    1979-01-01

    After making some general remarks about goals, tasks, and works of the World Energy Conference the topics and the frame of the 11th World Energy Conference which will take place in Munich from 8th to 12th September 1980 are outlined. This conference is held under the general topic 'energy for our world' and deals with the reciprocal relation between energy supply, environment, and society. The main part of the publication presented here is the German version of the most important sections of the investigation 'World Energy-Looking Ahead to 2020' by the Conservation Commission (CC) of the World Energy Conference. Added to this is the German original brief version of a report by the Mining-Research Company (Bergbau-Forschung GmbH) to the CC which deals with the estimation of the world's coal resources and their future availability. This report was presented on the 10th World Energy Conference in Istanbul together with the corresponding reports concerning the other energy sources. Finally, an introduction to the technical programme for the 11th World Energy Conference 1980 is given. (UA) [de

  20. Proceedings of the 5th Yugoslav Nuclear Society Conference (YUNSC-2004)

    International Nuclear Information System (INIS)

    Antic, D.

    2005-10-01

    The Fifth International Conference of the Yugoslav Nuclear Society (YUNSC-2004) was held in Belgrade from Monday, September 27, to Thursday, September 30, 2004. YUNSC-2004 is the fifth in the established series of conferences to be devoted to the promotion of scientific and technical co-operation of nuclear societies, especially of the countries in the Balkan region, and exchange of information and ideas between professionals in the nuclear field. One of the main goals, besides the good quality of the presented papers and the attendance of well-known experts, was the ambition of the Organising Committee to establish a traditional Yugoslav Nuclear Society conference that would gather nuclear experts from our country, Serbia and Montenegro experts currently working abroad and experts from neighboring and regional countries. The conference was organized by the Yugoslav Nuclear Society (YuNS) and coorganized by the VINCA Institute of Nuclear Sciences, Belgrade, Serbia and Montenegro. As an introduction to the conference, the future project 'Vinca Institute Nuclear Decommissioning Program' was promoted by Dr. Milan Pesic, program manager. At the conference, out of 100 papers (55 papers by foreign authors) , 23 were presented in 9 Oral Sessions, while 77 contributions were presented in the Poster Session. The Fifth International Yugoslav Nuclear Society Conference 2004 (YUNSC 2004) are grouped into 13 chapters: Future of nuclear energy (5 papers), Numerical Methods in nuclear reactor analysis and design (6), Nuclear power plants and reactor safety (9), Fuel cycle and waste management (10), Research Reactors and Reactor Physics (8), ADS and Accelerators (1), Nuclear methods in science and technology (26), Radiation Protection (5), Depleted uranium (3), Nuclear medicine (4), Radiation Medicine (7), Environment (4). Proceedings were printed in 200 copies on CD October 2005. A separate abstract was prepared for each of these papers.

  1. Consecutive Isoproterenol and Adenosine Treatment Confers Marked Protection against Reperfusion Injury in Adult but Not in Immature Heart: A Role for Glycogen

    Directory of Open Access Journals (Sweden)

    Martin Lewis

    2018-02-01

    Full Text Available Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden, known to consecutively activate PKA/PKC signaling, is cardioprotective against ischemia and reperfusion (I/R. Whether this is cardioprotective in an immature heart is unknown. Langendorff–perfused hearts from adult and immature (60 and 14 days old male Wistar rats were exposed to 30 min ischemia and 120 min reperfusion, with or without prior perfusion with 5 nM Iso for 3 min followed by 30 μM Aden for 5 min. Changes in hemodynamics (developed pressure and coronary flow and cardiac injury (Lactate Dehydrogenase (LDH release and infarct size were measured. Additional hearts were used to measure glycogen content. Iso induced a similar inotropic response in both age groups. Treatment with Iso/Aden resulted in a significant reduction in time to the onset of ischemic contracture in both age groups whilst time to peak contracture was significantly shorter only in immature hearts. Upon reperfusion, the intervention reduced cardiac injury and functional impairment in adults with no protection of immature heart. Immature hearts have significantly less glycogen content compared to adult. This work shows that Iso/Aden perfusion confers protection in an adult heart but not in an immature heart. It is likely that metabolic differences including glycogen content contribute to this difference.

  2. Title - EFARS - Conference (Uninvited)

    OpenAIRE

    Lohrey, MC; Lawrence, AS

    2016-01-01

    Abstract - EFARS - Conference (Uninvited) "Notes" - EFARS - Conference (Uninvited) In preparation (Publication status) Yes, full paperYes, abstract onlyNo (Peer reviewed?) "Add a comment" - EFARS - Conference - Uninvited

  3. Data protection and privacy : The age of intelligent machines

    NARCIS (Netherlands)

    Leenes, Ronald; van Brakel, Rosamunde; Gutwirth, Serge; de Hert, Paul

    2017-01-01

    This volume arises from the tenth annual International Conference on Computers, Privacy, and Data Protection (CPDP 2017) held in Brussels in January 2017, bringing together papers that offer conceptual analyses, highlight issues, propose solutions, and discuss practices regarding privacy and data

  4. AINSE's 40th anniversary conference. Conference handbook

    International Nuclear Information System (INIS)

    1998-01-01

    Highlights of 40 years of activity of the Australian Institute of Nuclear Science and Engineering (AINSE) were the main focus of this conference. Topics covered include nuclear physics, plasma physics, radiation chemistry, radiation biology, neutron diffraction, nuclear techniques of analysis and other relevant aspects of nuclear science and technology. The conference handbook contains the summaries of the 78 papers and posters presented and the list of participants

  5. Scientific trends in radiological protection of the environment

    International Nuclear Information System (INIS)

    Brechignac, F.; Howard, B.J.

    2005-01-01

    This volume brings together some of the most outstanding guest contributions at the 2. ECORAD International Conference held in Aix en Provence, France, on 6-10 September 2004. Traditionally dealing with Radioecology, this Conference event has focused on the 'scientific basis for environmental protection against ionising radiation'. The aim is to consider the current challenges faced by this scientific discipline in an emerging general context that places environmental protection issues on a par with human-related concerns. This is not just a trend or the latest conveniently-milked fashion, but the natural and credible consequence of the intensity of human activity, which is now encroaching in many different ways on both human and environmental health. The contributions included herein provide an advanced, updated and focused understanding that will help to ensure that environmental regulations currently at the centre of international debate are pertinent and adequate, and contribute to an increasingly efficient system of environmental intervention and crisis management. (authors)

  6. Crisis or Conference! Master List for Conference Planners.

    Science.gov (United States)

    Carey, Tony

    This conference organizer's guide contains 42 lists of ideas, reminders, things to check, and questions to ask when a person is planning an event such as a conference, workshop, or training session. Written from a British point of view, the guide is organized into four parts in chronological order: preplanning, planning, onsite, and…

  7. Insight conference reports : Ontario power summit : embrace the changes, face the challenges

    International Nuclear Information System (INIS)

    2002-01-01

    The main focus of this conference was on the current changes within Ontario's electricity industry and what can be learned from the experience of other jurisdictions. Opinions regarding the switch to open competition in Ontario on May 1, 2002 have been extremely varied. It was noted that open competition generally brings down electricity prices and is beneficial in introducing innovations. Opponents of competition are quick to point out that both California and Alberta have experienced the opposite with open markets. The presentations described the factors that contributed to the creation of an open electricity market in Ontario with reference to the unsustainable electricity rates of the 1990s. Participants at the conference also expressed their views regarding future electricity prices, and presented suggestions of how power transmission, distribution and generation can be optimized while protecting the consumer. A total of 18 papers were presented at the conference, of which 4 were indexed separately for inclusion in the database. refs., tabs., figs

  8. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2014

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-11-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2014. It was held on Nov.19-21, 2014 in Jeju, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2014. This proceedings is comprised of 8 sessions. The main topic titles of session are as follows: Radiation protection 1, Medical treatment and Biology 1, Radiation measurement 1, Radiation environment and protection 1, Radiation protection 2, Medical treatment and Biology 2, Radiation Measurement 2, Radiation environment and protection 2.

  9. Conference summaries

    International Nuclear Information System (INIS)

    1988-01-01

    This volume contains conference summaries of the 28. annual conference of the Canadian Nuclear Association, and the 9. annual conference of the Canadian Nuclear Society. Topics of discussion include: power reactors; fuel cycles; nuclear power and public understanding; future trends; applications of nuclear technology; CANDU reactors; operational enhancements; design of small reactors; accident behaviour in fuel channels; fuel storage and waste management; reactor commissioning/decommissioning; nuclear safety experiments and modelling; the next generation reactors; advances in nuclear engineering education in Canada; safety of small reactors; current position and improvements of fuel channels; current issues in nuclear safety; and radiation applications - medical and industrial

  10. Thermotolerance-induced goblet cell activity confers protection in post-operative gut barrier dysfunction.

    LENUS (Irish Health Repository)

    Ali, Rohana

    2009-06-01

    There is evidence that some level of protection against the adverse sequelae of surgery is provided by induction of thermotolerance; this protective effect was explored by study of several indicators of bowel wall damage in animals exposed to surgical insults. It has been argued that the mechanism of the protective effect of thermotolerance involves heat shock proteins (HSPs). We hypothesized that the protective effect of thermotolerance may be due in part to changes in the bowel wall itself, and we investigated this hypothesis in an experimental rat model.

  11. PHYTOREMEDIATION: STATE OF THE SCIENCE CONFERENCE AND OTHER DEVELOPMENTS. EDITORIAL INTRODUCTION AND SPECIAL COMMENTARY

    Science.gov (United States)

    It is a pleasure to present six papers in this issue, selected from presentations at the U.S. Environmental Protection Agency (EPA) Conference, Phytoremediation: State of the Science held May 1-2, 2000 in Boston, MA, USA. These papers highlight some of the many advances reported...

  12. EnviroInfo 2014 - ICT for energy efficiency. Conference proceedings

    International Nuclear Information System (INIS)

    Marx Gomez, Jorge; Rapp, Barbara; Giesen, Nils; Sonnenschein, Michael; Vogel, Ute; Winter, Andreas

    2014-01-01

    The main topics of this conference were: Sustainability Reporting; Renewable Energy; Environmental protection and health; Material flow management and LCA; Climate change and scarce resources; Tools for modelling and simulation of environmental systems; Biodiversity; Water management; Smart grids; Environmental Management Information Systems (EMIS); Green IT and Energy aware development; GIS: Techniques and applications; High performance computing and big data; Resource and energy efficiency; Cloud computing; Decision support; Carbon footprint; Green Business Process Management (BPM); Mobility and sensors.

  13. EnviroInfo 2014 - ICT for energy efficiency. Conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Marx Gomez, Jorge; Rapp, Barbara; Giesen, Nils [Oldenburg Univ. (Germany). Business Information Systems; Sonnenschein, Michael; Vogel, Ute [Oldenburg Univ. (Germany). Environmental Informatics; Winter, Andreas (ed.) [Oldenburg Univ. (Germany). Software Engineering

    2014-07-01

    The main topics of this conference were: Sustainability Reporting; Renewable Energy; Environmental protection and health; Material flow management and LCA; Climate change and scarce resources; Tools for modelling and simulation of environmental systems; Biodiversity; Water management; Smart grids; Environmental Management Information Systems (EMIS); Green IT and Energy aware development; GIS: Techniques and applications; High performance computing and big data; Resource and energy efficiency; Cloud computing; Decision support; Carbon footprint; Green Business Process Management (BPM); Mobility and sensors.

  14. Aerospace Environmental Technology Conference: Exectutive summary

    Science.gov (United States)

    Whitaker, A. F. (Editor)

    1995-01-01

    The mandated elimination of CFC's, Halons, TCA, and other ozone depleting chemicals and specific hazardous materials has required changes and new developments in aerospace materials and processes. The aerospace industry has been involved for several years in providing product substitutions, redesigning entire production processes, and developing new materials that minimize or eliminate damage to the environment. These activities emphasize replacement cleaning solvents and their application verifications, compliant coatings including corrosion protection systems, and removal techniques, chemical propulsion effects on the environment, and the initiation of modifications to relevant processing and manufacturing specifications and standards. The papers from this conference are being published in a separate volume as NASA CP-3298.

  15. International Cryocooler Conference

    CERN Document Server

    Cryocoolers 13

    2005-01-01

    This is the 13th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature super-capacitor applications.

  16. L-042: EPR-First Responders: Guidelines for protection of personnel

    International Nuclear Information System (INIS)

    2011-01-01

    This conference is about the guidelines of personal protection actions in a radiological emergency. The main aspect to considered are: dosimetry levels, pregnant women careful , radioactive sources, food, clothing, time spent in the accident site and contamination risk

  17. Proceedings of the 4th European conference on protection against radon at home and at work. Conference programme and session presentations

    International Nuclear Information System (INIS)

    2004-01-01

    The conference was divided into 6 sections as follows (the numbers of PDF files included in the CD-ROM are given in parentheses): 1. Radon measurement in dwellings (7); 2. Radon measurement at workplaces (14); 3. Methods of measurement and devices (16); 4. Remedial measures and techniques (5); 5. Preventive measures and techniques (10); and 6. National radon programmes (6). In addition, the CD-ROM contains 3, 11, 9, 5, 6, and 6 PowerPoint presentations shown in the six sections, respectively, plus a total of 93 abstracts, mostly of posters. (P.A.)

  18. Proceedings of NUCLEAR 2008 annual international conference on sustainable development through nuclear research and education

    International Nuclear Information System (INIS)

    Constantin, Marin; Turcu, Ilie

    2008-01-01

    The proceedings of the NUCLEAR 2008 annual international conference on sustainable development through nuclear research and education held at INR-Pitesti on May, 28 - 30 2008 contain 88 communications presented in 3 sections addressing the themes of Nuclear energy, Environmental protection, and Sustainable development. In turn these sections are addressing the following items: Section 1.1 - Nuclear safety and severe accidents (12 papers); Section 1.2 - Nuclear reactors (11 papers); Section 1.3 - Nuclear technologies and materials (20 papers); Section 2.1 - Radioprotection (5 papers); Section 2.2 - Radioactive waste management (20 papers); Section 2.3 - air, water and soil protection (5 papers); Section 3.1 - Strategies in energy (3 papers); Section 3.2 - Education, continuous formation and knowledge transfer (8 papers); Section 3.3 - International partnership for a sustainable development (4 papers). The conference proceedings where divided into two parts. This item refers particularly to the second part

  19. Water Conservation with Water Saving Devices, Proceedings of a Conference. Extension Bulletin 421.

    Science.gov (United States)

    Shelton, Theodore B., Ed.

    Presented are six papers on water conservation which were presented at a conference in New Jersey. The first two papers present recommendations of the New Jersey Department of Environmental Protection on water conservation and a master plan for New Jersey's water supply needs. The following four papers discuss water conservation with water-saving…

  20. [Coffee as hepatoprotective factor].

    Science.gov (United States)

    Szántová, Mária; Ďurkovičová, Zuzana

    The mind about the coffee did change upon the recent studies and metaanalysis of the last years. Consensual protective effect of coffee on the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocelullar carcinoma) was detected in experimental, clinical and large population studies together with decrease of mortality. Antioxidant, antifibrotic, insulinsensitizing and anticarcinogenic effect of coffee were detected. Modulation of genetic expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with decrease of proinflammatory cytokines and decrease of fibrogenesis are main mechanisms. Chlorogenic acids, diterpens (cafestol, kahweol), caffein, polyfenols and melanoidins are key protective components of coffee. Inverse dose-dependent correlation of coffee consumption with liver diseases was found in clinical and population studies. Coffee is non-pharmacological tool of primary and secondary prevention of chronic liver diseases. Review of published data together with supposed mechanisms of hepatoprotection are given.Key words: coffee - hepatoprotective effect - metaanalysis.

  1. Conference handbook. Seventh Conference on Nuclear Science and Engineering in Australia

    International Nuclear Information System (INIS)

    2007-01-01

    The Australian Nuclear Association (ANA) inaugurated a series of biennial national conferences in 1995 to be held in alternate years to the series of international Pacific Basin Nuclear Conferences, of which the ANA hosted the Ninth in the series in Sydney in May 1994 and the Fifteenth in Sydney in 2006. The main objective of these national conferences is to present information on important aspects of the peaceful uses of nuclear science and engineering in Australia and to place this information in a world context and in a readily understood form. These conferences have the general title of Nuclear Science and Engineering in Australia and have consisted mainly of papers invited from leading experts in areas of topical interest in nuclear science and technology supported by contributed poster papers. This seventh conference in 2007 has the special theme A Nuclear Future and also includes papers by invited speakers and contributed posters

  2. Strengthening global physical protection practices; gaining better information on national practices for protection of weapons-usable material. Keynote address/session 3

    International Nuclear Information System (INIS)

    Bunn, G.; Rinne, R.

    2001-01-01

    Full text: Unlike the Non-Proliferation Treaty requirement that non-nuclear-weapon parties provide 'safeguards' information to the IAEA on their nuclear materials and their state systems for accounting and control, there is no related requirement to provide information on state systems of physical protection. A review of 1997 IAEA and Stanford physical protection conference proceedings showed both the absence of information on important practices from many states and the great variation in practices from state to state. Besides the lack of internationally required standards for domestic protection, reasons for the variations described in Stanford-Sandia National Laboratories research include: differences in states' perceptions of the threats to their materials; differences in their abilities to pay the cost of stronger physical protection; differences in their laws and regulatory practices in general; and differences in their cultural attitudes - for example, attitudes toward whether to arm personnel guarding weapon-usable material or to require clearances for personnel with access to such material. The information presented to the 1997 IAEA and Stanford conferences was supplied voluntarily. The two global documents which provide norms for physical protection do not require submission of such information. These are the 1980 Convention on Physical Protection of Nuclear Material and the 1999 IAEA INFCIRC/225/Rev.4. This means that, without bilateral cooperation, no state can find out how other states are protecting their nuclear material. Yet, as IAEA Director General El Baradei has said, '[I]t is not a matter of indifference to other States whether and to what extent [physical protection] responsibility is fulfilled. ...The need for international cooperation becomes evident in situations - where the effectiveness of physical protection in one State depends on the taking by other States also of adequate measures to deter and defeat hostile actions against nuclear

  3. 59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program

    Science.gov (United States)

    2018-04-20

    REPORT TYPE 20/04/2018 poster 4. TITLE AND SUBTITLE 59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program 6. AUTHOR(S...13. SUPPLEMENTARY NOTES 2018 Annual AAHRPP Conference April 20-22, 2018 Denver, CO 14. ABSTRACT 1S. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF...59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program Wayne DeutschDDS1, MPH, Michele Tavish LYN, PMP, CCRC 1 Brenda

  4. Architecture of conference control functions

    Science.gov (United States)

    Kausar, Nadia; Crowcroft, Jon

    1999-11-01

    Conference control is an integral part in many-to-many communications that is used to manage and co-ordinate multiple users in conferences. There are different types of conferences which require different types of control. Some of the features of conference control may be user invoked while others are for internal management of a conference. In recent years, ITU (International Telecommunication Union) and IETF (Internet Engineering Task Force) have standardized two main models of conferencing, each system providing a set of conference control functionalities that are not easily provided in the other one. This paper analyzes the main activities appropriate for different types of conferences and presents an architecture for conference control called GCCP (Generic Conference Control Protocol). GCCP interworks different types of conferencing and provides a set of conference control functions that can be invoked by users directly. As an example of interworking, interoperation of IETF's SIP and ITU's H.323 call control functions have been examined here. This paper shows that a careful analysis of a conferencing architecture can provide a set of control functions essential for any group communication model that can be extensible if needed.

  5. The first conference of the Israel materials union. Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The Israel materials union is the union of the Israeli societies dealing with materials sciences and engineering. The presentations in the conference can be classified in accordance with the sessions headings as follows: thin films, tribology, electronic devices, crystal growing, future structural materials, chemistry, physics of condensed matter, metallurgy, surface coating and protection and vacuum. Main interesting materials are alloys, superconducting materials, composites, and glasses.

  6. The first conference of the Israel materials union. Program and abstracts

    International Nuclear Information System (INIS)

    1996-04-01

    The Israel materials union is the union of the Israeli societies dealing with materials sciences and engineering. The presentations in the conference can be classified in accordance with the sessions headings as follows: thin films, tribology, electronic devices, crystal growing, future structural materials, chemistry, physics of condensed matter, metallurgy, surface coating and protection and vacuum. Main interesting materials are alloys, superconducting materials, composites, and glasses

  7. Strengthening global practices for protecting nuclear material (NUMAT). Book of Abstracts

    International Nuclear Information System (INIS)

    Steinhaeusler, F.; Heissl, C.

    2002-08-01

    The International Conference on Physical Protection 'Strengthening Global Practices for Protecting Nuclear Material' was organized by the Institute of Physics and Biophysics, Salzburg University in cooperation with/supported by the European Commission, Lawrence Livermore National Laboratory, European Forum of the Stanford University's Institute for International Studies and Austria Institute for European Security. Its purpose was fostering exchange of information on the policy and technical aspects require to ensure the security of nuclear material around the world. There is a general concern that the international community needs to establish effective measures to counter theft, sabotage, and other illicit uses of nuclear fissile and other radioactive materials. The main subjects addressed by this conference were: a) global and local threat development and 'design basis'; b) standards for physical protection (PP), its adequacy and future needs; c) national practices in PP of nuclear materials (how to strengthen national security culture?); d) current R and D in security and detection technologies (identification of focus points for future R and D); e) programmes to aid in training, design, and implementation of physical protection systems (how to improve efficiency and assure sustainability of assistance programmes?). (nevyjel)

  8. Light deficiency confers breast cancer risk by endocrine disorders.

    Science.gov (United States)

    Suba, Zsuzsanna

    2012-09-01

    North-America and northern European countries exhibit the highest incidence rate of breast cancer, whereas women in southern regions are relatively protected. Immigrants from low cancer incidence regions to high-incidence areas might exhibit similarly higher or excessive cancer risk as compared with the inhabitants of their adoptive country. Additional cancer risk may be conferred by incongruence between their biological characteristics and foreign environment. Many studies established the racial/ethnic disparities in the risk and nature of female breast cancer in United States between African-American and Caucasian women. Mammary tumors in black women are diagnosed at earlier age, and are associated with higher rate of mortality as compared with cancers of white cases. Results of studies on these ethnic/racial differences in breast cancer incidence suggest that excessive pigmentation of dark skinned women results in a relative light-deficiency. Poor light exposure may explain the deleterious metabolic and hormonal alterations; such as insulin resistance, deficiencies of estrogen, thyroxin and vitamin-D conferring excessive cancer risk. The more northern the location of an adoptive country the higher the cancer risk for dark skinned immigrants. Recognition of the deleterious systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment. Recent patents provide new methods for the prevention of hormonal and metabolic abnormities.

  9. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2013

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-11-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2013. It was held on Nov.20-22, 2013 Ramada Plaza Hotel in Suwon, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2013. This proceedings is comprised of 7 sessions. The main topic titles of session are as follows: Medical treatment and Biology 1, Measurement and Analysis 1, Radiation protection1, Medical treatment and Biology 2, Measurement and Analysis 2, Radiation protection 2, Radiation protection 3.

  10. Proceedings of the Sudbury 2003 Mining and the Environment Conference

    International Nuclear Information System (INIS)

    Spiers, G.; Beckett, P.; Conroy, H.

    2003-01-01

    Sudbury is considered to be the centre of the Canadian mining industry and has gained a reputation for environmentally sound mining practices that are being met through mine site rehabilitation and regional land reclamation. This international conference provided a forum to exchange ideas and information pertinent to mine reclamation activities. More than 400 delegates, including leading scientists and technical experts from around the world participated at the conference. Approximately 150 papers were presented on a wide range of topics related to mine site rehabilitation issues and environmental protection methods associated with mining. Both current and future challenges faced by the mining industry were discussed with particular reference to the long-term sustainability of the mining process. Topics of discussion included issues pertaining to reclamation and rehabilitation of disturbed lands and waterways as well as specific site reclamation challenges associated with the oil industry. Reclamation activities include a wide range of expertise including plant ecology, forestry, soil science, land use planning, civil and mine engineering, wildlife biology, and reclamation. Six papers from the conference have been processed separately for inclusion in this database. refs., tabs., figs

  11. International Conference on Nuclear Security: Enhancing Global Efforts. Summary of an International Conference

    International Nuclear Information System (INIS)

    2014-01-01

    The International Conference on Nuclear Security: Enhancing Global Efforts was organized by the IAEA and held in Vienna on 1-5 July 2013. The conference was organized in cooperation with the following organizations and initiatives: the European Union; the Global Initiative to Combat Nuclear Terrorism (GICNT); the International Criminal Police Organization (INTERPOL); the Institute of Nuclear Materials Management (INMM); the Nuclear Threat Initiative (NTI); the Organization for Security and Co-operation in Europe (OSCE); the Partnership for Global Security; the Police Community of the Americas (AMERIPOL); the United Nations Interregional Crime and Justice Research Institute (UNICRI); the United Nations Office on Drugs and Crime (UNODC); the World Institute for Nuclear Security (WINS); the World Nuclear Association (WNA); and the World Nuclear Transport Institute (WNTI). A total of 34 ministers participated in the ministerial session of the conference. Altogether, the conference attracted more than 1300 registered participants from 125 IAEA Member States and 21 organizations. The aim of the conference was to review the international community's experience and achievements to date in strengthening nuclear security, to enhance the understanding of current approaches to nuclear security worldwide and identify trends, and to provide a global forum for ministers, policymakers and senior officials to formulate views on future directions and priorities for nuclear security. This book contains the President's Summary of the conference and a summary of the ministerial session, the full text of the ministerial declaration adopted by the conference and summaries of the main conference sessions. The attached CD-ROM contains the full conference programme, the list of conference participants, the national statements from the ministerial session and a selection of papers

  12. 5th International Conference on Advanced Manufacturing Engineering and Technologies

    CERN Document Server

    Jakovljevic, Zivana; NEWTECH2017

    2017-01-01

    This book presents the proceedings from the 5th NEWTECH conference (Belgrade, Serbia, 5–9 June 2017), the latest in a series of high-level conferences that bring together experts from academia and industry in order to exchange knowledge, ideas, experiences, research results, and information in the field of manufacturing. The range of topics addressed is wide, including, for example, machine tool research and in-machine measurements, progress in CAD/CAM technologies, rapid prototyping and reverse engineering, nanomanufacturing, advanced material processing, functional and protective surfaces, and cyber-physical and reconfigurable manufacturing systems. The book will benefit readers by providing updates on key issues and recent progress in manufacturing engineering and technologies and will aid the transfer of valuable knowledge to the next generation of academics and practitioners. It will appeal to all who work or conduct research in this rapidly evolving field.

  13. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Spring Meeting 2014

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-04-15

    This proceedings contains articles of the Korean Association for Radiation Protection Spring Meeting, 2014. It was held on Apr.23-25, 2014 Grand Hotel in Busan, Korea and subject of the Korean Association for Radiation Protection Spring Meeting 2014. This proceedings is comprised of 8 sessions. The main topic titles of session are as follows: Medical treatment and Biology 1, Measurement and Analysis 1, Measurement and Analysis 2, Radiation protection 1, Radiation protection 2, Medical treatment and Biology 2, Measurement and Analysis 3, Radiation protection 3.

  14. Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase in rat hepatocytes

    NARCIS (Netherlands)

    Post, S.M.; Wit, E.C.M. de; Princen, H.M.G.

    1997-01-01

    Consumption of boiled coffee raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase. To investigate the biochemical background of this effect, we studied the effects of cafestol and a mixture of

  15. 1993 International oil spill conference: Prevention, preparedness, response

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    This book contains the proceedings of the 1993 International Oil Spill Conference which took place March 29 - April 1 in Tampa, Florida. It was jointly sponsored by the American Petroleum Institute, the US Coast Guard, and the US Environmental Protection Agency. Topics discussed included all aspects of spill prevention and preparedness, including planning, training, and research and development. Response issues, including fate and effects of spilled oil, cleanup, bioremediation, and in situ burning were also discussed. Legal and economic issues were also analyzed in the form of case studies

  16. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2012. It was held on Nov. 28-30, 2012 Phoenix Island in Jeju, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2012. This proceedings is comprised of 8 sessions. The main topic titles of session are as follows: The main topic titles of session are as follows: Medical treatment and Biology 1, Measurement and Analysis 1, Measurement and Analysis 2, Radiation protection 1, Radiation protection 2, Medical treatment and Biology 2, Measurement and Analysis 3, Radiation protection 3.

  17. Vaccine-induced protection against anthrax in cheetah (Acinonyx jubatus) and black rhinoceros (Diceros bicornis).

    Science.gov (United States)

    Turnbull, P C B; Tindall, B W; Coetzee, J D; Conradie, C M; Bull, R L; Lindeque, P M; Huebschle, O J B

    2004-09-03

    Institution of a policy of vaccination in endangered species with a vaccine not previously administered to it cannot be undertaken lightly. This applies even more in the case of cheetah (Acinonyx jubatus) with their unusually monomorphic gene pool and the potential restrictions this places on their immune responses. However, the recently observed mortalities from anthrax in these animals in the Etosha National Park, Namibia, made it imperative to evaluate vaccination. Black rhinoceros (Diceros bicornis), another endangered species in the park, have been vaccinated for over three decades but the effectiveness of this has never been evaluated. Passive protection tests in A/J mice using sera from 12 cheetahs together with enzyme immunoassay indicated that cheetah are able to mount seemingly normal primary and secondary humoral immune responses to the Sterne 34F2 live spore livestock vaccine. Overall protection rates in mice injected with the sera rose and fell in concert with rises and declines in antibody titres, although fine analysis showed that the correlation between titre and protection was complex. Once a high level of protection (96% of mice 1 month after a second booster in the cheetahs) had been achieved, the duration of substantial protection appeared good (60% of the mice 5 months after the second booster). Protection conferred on mice by sera from three of four vaccinated rhino was almost complete, but, obscurely, none of the mice receiving serum from the fourth rhino were protected. Sera from three park lions with naturally acquired high antibody titres, included as controls, also conferred high levels of protection. For the purposes of wildlife management, the conclusions were that vaccination of cheetah with the standard animal anthrax vaccine causes no observable ill effect in the animals and does appear to confer protective immunity. At least one well-separated booster does appear to be desirable. Vaccination of rhino also appears to be justified

  18. AINSE`s 40th anniversary conference. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    Highlights of 40 years of activity of the Australian Institute of Nuclear Science and Engineering (AINSE) were the main focus of this conference. Topics covered include nuclear physics, plasma physics, radiation chemistry, radiation biology, neutron diffraction, nuclear techniques of analysis and other relevant aspects of nuclear science and technology. The conference handbook contains the summaries of the 78 papers and posters presented and the list of participants

  19. Joint US/German Conference

    CERN Document Server

    Gulledge, Thomas; Jones, Albert

    1993-01-01

    This proceedings volume contains selected and refereed contributions that were presented at the conference on "Recent Developments and New Perspectives of Operations Research in the Area of Production Planning and Control" in Hagen/Germany, 25. - 26. June 1992. This conference was organized with the cooperation of the FernuniversiHit Hagen and was jointly hosted by the "Deutsche Gesellschaft fur Operations Research (DGOR)" and the "Manufacturing Special Interest Group of the Operations Research Society of America (ORSA-SIGMA)". For the organization of the conference we received generous financial support from the sponsors listed at the end of this volume. We wish to express our appreciation to all supporters for their contributions. This conference was the successor of the JOInt ORSA/DGOR-conference in Gaithersburg/Maryland, USA, on the 30. and 31. July 1991. Both OR-societies committed themselves in 1989 to host joint conferences on special topics of interest from the field of operations research. This goal ...

  20. 20. AINSE plasma science and technology conference. Conference handbook

    International Nuclear Information System (INIS)

    1995-01-01

    The 20th AINSE plasma science and technology conference was held at Flinders University of South Australia on 13-14 February 1995. Topics under discussion included plasma physics studies, current status of rotamak devices, plasma processing and material studies. The handbook contains the conference program, 54 abstracts and a list of participants

  1. 20. AINSE plasma science and technology conference. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The 20th AINSE plasma science and technology conference was held at Flinders University of South Australia on 13-14 February 1995. Topics under discussion included plasma physics studies, current status of rotamak devices, plasma processing and material studies. The handbook contains the conference program, 54 abstracts and a list of participants.

  2. Conference summaries

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Tim [Inta Communication Limited for European Service Network/ DG Research, Trillium House, 32 New Street, St. Neots, Cambridge PE19 1AJ (United Kingdom)

    2004-07-01

    The summaries were derived from presentations, interviews and discussions at the conference. The summaries are given at two levels, overall for the conference and for specific sessions as follows: 1) Overall Conference: 'A Sound Scientific Basis for Serious Decisions; 2) Sessions on EC Policy and Socio-Political Issues: 'Promoting Safety and Protecting Society'; 3) Session on P and T: 'Partitioning and Transmutation: A Technical Fix or Technical Training?'; 4) Sessions on Geological Disposal and Research Networking: 'No Technical Barriers to Geological Disposal'. First an overall summary of Euradwaste '04 is presented. Significant progress was made on the technical and scientific basis for geological disposal of radioactive waste during the European Commission's Fifth EURATOM Framework Programme for Research (FP5). Deep geological disposal is technically feasible now and can demonstrate the guarantees of long-term isolation and protection of the public. In parallel, socio-political studies have produced methodologies for constructive dialogue with potential host communities that reflect the honesty and openness expected by a democratic society. A harmonized legislative framework for nuclear safety and waste disposal across the enlarged European Union is currently being discussed. Disposal in deep (> 300 metre) geological repositories, the favoured strategy in Europe for long-lived high-level radioactive waste, is now possible. The Sessions on EC Policy and Socio-Political Issues are summarized as follows. The opening day of Euradwaste '04 focused on European Commission policy, including the proposed Directives on disposal of radioactive waste and nuclear safety and socio-political aspects including governance and decision making, public perception/acceptance of waste disposal and its sustainability. A decision on the proposed package will now be made after Union enlargement. Public agreement on the siting of

  3. Conference summaries

    International Nuclear Information System (INIS)

    1986-01-01

    This volume contains conference summaries of the international conference on radioactive waste management of the Canadian Nuclear Society. Topics of discussion include: storage and disposal; hydrogeology and geochemistry; transportation; buffers and backfill; public attitudes; tailings; site investigations and geomechanics; concrete; economics; licensing; matrix materials and container design; durability of fuel; biosphere modelling; radioactive waste processing; and, future options

  4. INFCE plenary conference documents

    International Nuclear Information System (INIS)

    This document consists of the reports to the First INFCE Plenary Conference (November 1978) by the Working Groups a Plenary Conference of its actions and decisions, the Communique of the Final INFCE Plenary Conference (February 1980), and a list of all documents in the IAEA depository for INFCE

  5. Designing Scientific Academic Conferences as a Learning Environment: How to Stimulate Active Learning at Academic Conferences?

    DEFF Research Database (Denmark)

    Verbeke, Johan

    2015-01-01

    conference design and an appropriate learning environment are available. The overall conference design, however, is a crucial aspect in the learning of the participants and deserves special attention from conference organizers. Method: I have organized around 15 carefully designed conferences (and attended...... architecture, arts and design) and on the way knowledge sharing and knowledge development was stimulated at these events. These conferences included less traditional conference designs, collective learning and explicit sharing of understanding between participants. Results: Collaboration in small groups...... for discussing and learning makes a huge difference in sharing and developing new knowledge. This paper aims to highlight the importance and raise awareness of different methods of stimulating the construction of knowledge by conference participants. I hope it will inspire future conference organizers and help...

  6. L-061: EPR--First responders: Risk and Protection radiological emergency

    International Nuclear Information System (INIS)

    2011-01-01

    This conference is about the basic risks, protection and the consequences in a radiological emergency. The first responders have to know the deterministic and stochastic effects in the health as well as the cancer risk due of the high radioactive doses exposure

  7. Index to conference titles; selected conferences cited in the ERDA data base 1972--1977

    International Nuclear Information System (INIS)

    Hardin, N.E.; McGinnis, D.H.

    1977-08-01

    This publication cites energy-related conferences, meetings, symposia, and congresses within the programmatic interests of the Energy Research and Development Administration. It supplements and overlaps Index to Conferences Assigned CONF-Numbers by the Technical Information Center, U.S. Atomic Energy Commission (TID-4045), citing conferences held since January 1, 1972, and assigned a number in the CONF report number series. The Index contains two computer-produced listings, a KWIC (Key-Word-In-Context) index of the conference location and title and a listing numerically arranged by CONF number and providing location, date, and title information for each conference

  8. Sakharov readings 2016: environmental problems of the XXI century. Proceedings of the 16 international scientific conference

    International Nuclear Information System (INIS)

    Maskevich, S.A.; Poznyak, S.S.; Lysukho, N.A.

    2016-05-01

    The proceeding includes materials of reports of 16-th international scientific conference 'Sakharov readings 2016: Environmental problems of XXI century', which took place 19-20 of May 2015 in the International A. Sakharov Environmental Institute at the Belarus State University (Minsk, Belarus). The proceeding continues abstracts about philosophical, social-ecological and bioethical problems of modernity; education for sustainable development; medical ecology; biological ecology; radiobiology; radioecology and radiation protection; information systems and technologies in ecology and medicine; regional environmental problems; ecological monitoring and management; renewable energy sources and energy efficiency. In the framework of conference a discussion 'Ethical aspects of biomedicine, genetics, nanomedical technologies and human ecology' was conducted. Materials of the conference intend on wide area of the specialists in ecology and adjacent sciences, teachers, post-graduate students and students of universities and colleges. (authors)

  9. Conference proceedings ISES 2014

    DEFF Research Database (Denmark)

    Christensen, Janne Winther; Peerstrup Ahrendt, Line; Malmkvist, Jens

    The 10th Internatinal Equitation Science Conference is held i Denmark from August 6th - 9th 2014. This book of proceedings contaions abstracts of 35 oral and 57 poster presentations within the conference themes Equine Stress, Learning and Training as well as free papers.......The 10th Internatinal Equitation Science Conference is held i Denmark from August 6th - 9th 2014. This book of proceedings contaions abstracts of 35 oral and 57 poster presentations within the conference themes Equine Stress, Learning and Training as well as free papers....

  10. Extended abstracts for an international conference on the development of the North and problems of recultivation

    Energy Technology Data Exchange (ETDEWEB)

    Everett, K.R. [ed.

    1994-12-31

    Ecological problems in many regions on Earth are the result of increasing technological pressure on the environment. These problems concern many of us and cause mankind to unite in order to search for means to protect the environment. Scientists, especially are responsible for the protection of the biosphere. The objective of this conference was to discuss the results of studies on the present condition of the environment in the Far North where the industrial pressure is increasing. The participants of this conference also offered and suggested various necessary measures for the protection of the region and restoration of its disturbed sites. The specific structural characteristics of the environment of the Far North, tundra and northern taiga, cause its fragility and vulnerability to anthropogenic impact. The destruction of the thin, weak layer of soil and vegetation cover changes the thermal balance and thus causes the development of erosion process, which in their turn increase the zone of the direct technogenous destruction. Self restoration processes in this harsh climate usually are slow. The preservation of the ecological integrity in the Far North is essential for the stability of the biosphere of the planet. The specifics of the natural conditions must be taken into account so that man will be able to develop the means of intensive agro-technology that can speed up the process of restoration of the biocenosis in the damaged areas. The extended abstracts of the conference reports that constitute this volume contain both theoretical discussions of problems of recultivation as well as accounts of experimental studies and applied explorations.

  11. Conference summaries of the Canadian Nuclear Association 30. annual conference, and the Canadian Nuclear Society 11. annual conference

    International Nuclear Information System (INIS)

    1990-01-01

    This volume contains conference summaries for the 30. annual conference of the Canadian Nuclear Association, and the 11. annual conference of the Canadian Nuclear Society. Topics of discussion include: energy needs and challenges facing the Canadian nuclear industry; the environment and nuclear power; the problems of maintaining and developing industrial capacity; the challenges of the 1990's; programmes and issues for the 1990's; thermalhydraulics; reactor physics and fuel management; nuclear safety; small reactors; fuel behaviour; energy production and the environment; computer applications; nuclear systems; fusion; materials handling; and, reactor components

  12. Intranasal immunization with fusion protein MrpH·FimH and MPL adjuvant confers protection against urinary tract infections caused by uropathogenic Escherichia coli and Proteus mirabilis.

    Science.gov (United States)

    Habibi, Mehri; Asadi Karam, Mohammad Reza; Shokrgozar, Mohammad Ali; Oloomi, Mana; Jafari, Anis; Bouzari, Saeid

    2015-04-01

    Urinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC) and Proteus mirabilis are among the most common infections in the world. Currently there are no vaccines available to confer protection against UTI in humans. In this study, the immune responses and protection of FimH of UPEC with MrpH antigen of P. mirabilis in different vaccine formulations with and without MPL adjuvant were assessed. Mice intranasally immunized with the novel fusion protein MrpH·FimH induced a significant increase in IgG and IgA in serum, nasal wash, vaginal wash, and urine samples. Mice immunized with fusion MrpH·FimH also showed a significant boost in cellular immunity. Addition of MPL as the adjuvant enhanced FimH and MrpH specific humoral and cellular responses in both systemic and mucosal samples. Vaccination with MrpH·FimH alone or in combination with MPL showed the highest efficiency in clearing bladder and kidney infections in mice challenged with UPEC and P. mirabilis. These findings may indicate that the protection observed correlates with the systemic, mucosal and cellular immune responses induced by vaccination with these preparations. Our data suggest MrpH·FimH fusion protein with or without MPL as adjuvant could be potential vaccine candidates for elimination of UPEC and P. mirabilis. These data altogether are promising and these formulations are good candidates for elimination of UPEC and P. mirabilis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. CERN automatic audio-conference service

    International Nuclear Information System (INIS)

    Sierra Moral, Rodrigo

    2010-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  14. CERN automatic audio-conference service

    Energy Technology Data Exchange (ETDEWEB)

    Sierra Moral, Rodrigo, E-mail: Rodrigo.Sierra@cern.c [CERN, IT Department 1211 Geneva-23 (Switzerland)

    2010-04-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  15. CERN automatic audio-conference service

    Science.gov (United States)

    Sierra Moral, Rodrigo

    2010-04-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  16. International Conference on New Technologies in the Humanities and Fourth International Conference on Optics Within Life Sciences

    CERN Document Server

    Bally, Gert

    1997-01-01

    New high-tech developments in the field of optics show increasing applicability not only in classical technological fields but also in the humanities. This book contains selected contributions to an international, interdisciplinary joint conference on "New Technologies in the Humanities" and "Optics Within Life Sciences". Its objective is to forward interdisciplinary information and communication between specialists in optics as well as in medicine, biology, environmental sciences, and cultural heritage. It is unique as a presentation of new optical technologies for cultural heritage protection. The contributions cover international research activities in the areas of archaeological research and new technologies, holography and interferometry, material analysis, laser cleaning, pattern recognition, unconventional microscopy, spectroscopial techniques, and profilometry.

  17. Proceedings of the 21 conference of the nuclear societies in Israel. Final program and book of summaries

    International Nuclear Information System (INIS)

    2002-01-01

    On the occasion of the 50 anniversary of the Israel Atomic Energy Commission, there was held the 21 conference of the Nuclear Societies in Israel. The presentations addressed various aspects in the fields of nuclear industry, radiation protection and nuclear medicine

  18. Conferences are like swans

    OpenAIRE

    Corker, Chris

    2012-01-01

    Chris Corker was the lead on bringing the 2011 Higher Education Research Scholarship Group Conference to fruition, both in the months preceding the event and on the day. In this viewpoint, Chris shares his experiences of conference administration and delivery, and explores how conferences and swans have more in common that you would imagine.

  19. Computational Intelligence : International Joint Conference

    CERN Document Server

    Rosa, Agostinho; Cadenas, José; Dourado, António; Madani, Kurosh; Filipe, Joaquim

    2016-01-01

    The present book includes a set of selected extended papers from the sixth International Joint Conference on Computational Intelligence (IJCCI 2014), held in Rome, Italy, from 22 to 24 October 2014. The conference was composed by three co-located conferences:  The International Conference on Evolutionary Computation Theory and Applications (ECTA), the International Conference on Fuzzy Computation Theory and Applications (FCTA), and the International Conference on Neural Computation Theory and Applications (NCTA). Recent progresses in scientific developments and applications in these three areas are reported in this book. IJCCI received 210 submissions, from 51 countries, in all continents. After a double blind paper review performed by the Program Committee, 15% were accepted as full papers and thus selected for oral presentation. Additional papers were accepted as short papers and posters. A further selection was made after the Conference, based also on the assessment of presentation quality and audience in...

  20. PREFACE: International Conference on Image Optimisation in Nuclear Medicine (OptiNM)

    Science.gov (United States)

    Christofides, Stelios; Parpottas, Yiannis

    2011-09-01

    Conference logo The International Conference on Image Optimisation in Nuclear Medicine was held at the Atlantica Aeneas Resort in Ayia Napa, Cyprus between 23-26 March 2011. It was organised in the framework of the research project "Optimising Diagnostic Value in SPECT Myocardial Perfusion Imaging" (YΓΕΙΑ/ΔYΓΕΙΑ/0308/11), funded by the Cyprus Research Promotion Foundation and the European Regional Development Fund, to present the highlights of the project, discuss the progress and results, and define future related goals. The aim of this International Conference was to concentrate on image optimization approaches in Nuclear Medicine. Experts in the field of nuclear medicine presented their latest research results, exchanged experiences and set future goals for image optimisation while balancing patient dose and diagnostic value. The conference was jointly organized by the Frederick Research Centre in Cyprus, the Department of Medical and Public Health Services of the Cyprus Ministry of Health, the Biomedical Research Foundation in Cyprus and the AGH University of Science and Technology in Poland. It was supported by the Cyprus Association of Medical Physics and Biomedical Engineering, and the Cyprus Society of Nuclear Medicine. The conference was held under the auspices of the European Federation of Organisations for Medical Physics and the European Association of Nuclear Medicine. The conference scientific programme covered several important topics such as functional imaging; image optimization; quantification for diagnosis; justification; simulations; patient dosimetry, staff exposures and radiation risks; quality assurance and clinical audit; education, training and radiation protection culture; hybrid systems and image registration; and new and competing technologies. The programme consisted of 13 invited and keynote presentations as well as workshops, round table discussions and a number of scientific sessions. A total of 51 speakers presented their

  1. 2nd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Mulder, Bob; Choukroun, Daniel; Kampen, Erik-Jan; Visser, Coen; Looye, Gertjan

    2013-01-01

    Following the successful 1st CEAS (Council of European Aerospace Societies) Specialist Conference on Guidance, Navigation and Control (CEAS EuroGNC) held in Munich, Germany in 2011, Delft University of Technology happily accepted the invitation of organizing the 2nd  CEAS EuroGNC in Delft, The Netherlands in 2013. The goal of the conference is to promote new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems using on-board sensing, computing and systems. A great push for new developments in GNC are the ever higher safety and sustainability requirements in aviation. Impressive progress was made in new research fields such as sensor and actuator fault detection and diagnosis, reconfigurable and fault tolerant flight control, online safe flight envelop prediction and protection, online global aerodynamic model identification, online global optimization and flight upset recovery. All of these challenges de...

  2. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Spring Meeting 2013

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-04-15

    This proceedings contains articles of the Korean Association for Radiation Protection Spring Meeting, 2013. It was held on Apr.24-26, 2013 Hotel Hyundai Mokpo in Mokpo, Korea and subject of the Korean Association for Radiation Protection Spring Meeting 2013. This proceedings is comprised of 6 sessions. The main topic titles of session are as follows: Medical treatment and Biology 1, Measurement and Analysis 1, Radiation protection1, Medical treatment and Biology 2, Measurement and Analysis 2, Radiation protection 2.

  3. Index to conference titles: selected conferences cited in the Energy Data Base 1977-1982

    International Nuclear Information System (INIS)

    Vannoy, D.M.

    1982-05-01

    This publication cites energy-related conferences, meetings, symposia, and congresses within the programmatic interests of the US Department of Energy. It supplements Index to Conference Titles: Selected Conferences Cited in the ERDA Data Base 1972-1977, TIC-4045-S1, August 1977, and includes conferences held since January 1, 1977, which have been assigned a number in the CONF- report number series. The CONF- number is a six- or seven-digit code. The first two digits represent the years in which the conference was held; the next two represent the month; and the remaining digits are the accession number assigned by the DOE Technical Information Center

  4. Selected problems of protecting and managing historical ruins in Poland

    Directory of Open Access Journals (Sweden)

    Anna Fortuna-Marek

    2017-12-01

    Full Text Available Historical ruins have long been the object of interest for the research –workers of various disciplines as well as the conservators of historical monuments. The main problem is the form of protection. The standard of protecting ruins in the so-called permanent ruin form was elaborated two centuries ago, however, it is still the subject of numerous discussions, conferences, scientific-research works. The main source of doubts as to the permanent ruin is its incompleteness,(deficiency illegibility and the highly restricted possibilities of making any use of it, whereas the contemporary protection of monuments assumes their accessibility and the widest possible use for contemporary functions. That is why the main issue in contemporary maintenance of historical ruins is to ensure them a proper management system. The problem of protecting historical ruins has universal character. In Poland it concerns the resources of about 200 historical ruins, first and foremost of the mediaeval castles. That is why the Polish conservator circles have intensified the works aiming at the solution of the problem through the organization of programs, projects and conferences. A highly estimated result of those efforts is a programmatic document entitled “The Protection Charter of Historical Ruins”. It comprises a set of rules that determine the form of maintenance of historical ruins. However, the issues of management, development and use of the historical ruins still await a solution.

  5. The learning conference

    DEFF Research Database (Denmark)

    Ravn, Ib

    little support amongst serious students of learning. The professional conference as a forum for knowledge sharing is in dire need of a new learning theory and a more enlightened practice. The notion of human flourishing is offered as basis for theory, and four simple design principles for the so......The typical one-day conference attended by managers or professionals in search of inspiration is packed with PowerPoint presentations and offers little opportunity for involvement or knowledge sharing. Behind the conventional conference format lurks the transfer model of learning, which finds......-called “learning conference” are proposed: People go to conferences to 1. get concise input, 2. interpret it in the light of their ongoing concerns, 3. talk about their current projects and 4. meet the other attendees and be inspired by them. Six practical techniques that induce attendees to do these things...

  6. Radiation protection and communication. Sociology and communication impact in radiation protection; Radioprotection et Communication. Sociologie et impact de la communication en radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Berne, G [CEA/Cadarache, Service de Protection contre les Rayonnements, 13 - Saint Paul lez Durance (France); Bicheron, G; Franco, P [CEA/Fontenay aux Roses, Inst. de Protection et de Surete Nucleaire, IPSN, 92 (France); and others

    2000-07-01

    Communication about nuclear energy was the subject of this conference. Different examples of communications are detailed in fields as different as impact of iodine 131 release in waste waters or public information about radiation protection, the north Cotentin radioecology group or what information to give to the patients in nuclear medicine. (N.C.)

  7. CERN automatic audio-conference service

    CERN Multimedia

    Sierra Moral, R

    2009-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  8. CERN automatic audio-conference service

    CERN Document Server

    Sierra Moral, R

    2010-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  9. Proceedings of the 5. biennial international pipeline conference, IPC 2004 : the power of technology

    International Nuclear Information System (INIS)

    Paulson, K.; Kraft, H.; Hopkins, P.

    2004-01-01

    The fifth international pipeline conference provided a forum for experts in the pipeline industry, academia and governments to discuss new technologies and approaches to pipeline transport. Presentations focused on a wide range of issues related to pipeline engineering. The conference was divided into 16 main sessions: (1) compression and pump technologies, (2) corrosion protection and analysis techniques, (3) pipeline design and construction, (4) environmental issues, (5) database development, (6) emerging issues and innovative projects, (7) inspection techniques, (8) integrity management, (9) joining, (10) materials, (11) offshore issues, (12) operations and maintenance, (13) pipeline automation and measurement, (14) pipelining in northern environments, (15) risk and reliability, (16) standards and regulations. The presentations provided up-to-date information related to future technology trends as well as recent innovations and practices. Pipeline design standards and new pipeline materials using high strength steels and reinforced composite plastic coatings were also reviewed. Other sessions discussed emerging technologies for inspection, quality control, ultrasonic testing, and the use of remote sensors. The conference also included a student paper competition. A total of 339 peer reviewed presentations were given at the conference, all of which were indexed separately for inclusion in this database. refs., tabs., fig.

  10. Biochemical analysis of plant protection afforded by a nonpathogenic endophytic mutant of Colletotrichum magna

    Energy Technology Data Exchange (ETDEWEB)

    Redman, R.S.; Rodriguez, R.J. (Geological Survey, Seattle, WA (United States) Univ. of Washington, Seattle, WA (United States). Dept. of Botany); Clifton, D.R.; Morrel, J.; Brown, G. (Geological Survey, Seattle, WA (United States)); Freeman, S. (Volcani Center, Bet Dagan (Israel). Dept. of Plant Pathology)

    1999-02-01

    A nonpathogenic mutant of Colletotrichum magna (path-1) was previously shown to protect watermelon (Citrullus lanatus) and cucumber (Cucumis sativus) seedlings from anthracnose disease elicited by wild-type C. magna. Disease protection was observed in stems of path-1-colonized cucurbits but not in cotyledons, indicating that path-1 conferred tissue-specific and/or localized protection. Plant biochemical indicators of a localized and systemic (peroxidase, phenylalanine ammonia-lyase, lignin, and salicylic acid) plant-defense response were investigated in anthracnose-resistant and-susceptible cultivars of cucurbit seedlings exposed to four treatments: (1) water (control), (2) path-1 conidia, (3) wild-type conidia, and (4) challenge conditions (inoculation into path-1 conidia for 48 h and then exposure to wild-type conidia). Collectively, these analyses indicated that disease protection in path-1-colonized plants was correlated with the ability of these plants to mount a defense response more rapidly and to equal or greater levels than plants exposed to wild-type C. magna alone. Watermelon plants colonized with path-1 were also protected against disease caused by Colletotrichum orbiculare and Fusarium oxysporum. A model based on the kinetics of plant-defense activation is presented to explain the mechanism of path-1-conferred disease protection.

  11. International conference on security of nuclear material and radioactive sources opens in Stockholm

    International Nuclear Information System (INIS)

    2001-01-01

    The IAEA develops basic guidelines that have proven to be of significant importance in the development of national physical protection systems and international agreements. The IAEA has initiated a number of activities, including training, technology transfer and peer review, to support Member States in improving their nuclear material accountancy and physical protection systems at State and facility levels. The Agency also maintains a database of reported incidents. The Conference is organized by the IAEA, hosted by Swedish Nuclear Power Inspectorate and held in co-operation with the World Customs Organization, the International Criminal Police Organization (INTERPOL) and the European Police Office

  12. Strengthening the Convention on the Physical Protection of Nuclear Materials and Nuclear Facilities Regime: A Path Forward

    International Nuclear Information System (INIS)

    Pitts-Kiefer, S.; Nalabandian, M.

    2017-01-01

    With entry into force of the 2005 Amendment to the Convention on the Physical Protection of Nuclear Material (CPPNM) on May 8, 2016, and the culmination of the Nuclear Security Summits (NSS), the Convention on the Physical Protection of Nuclear Materials and Nuclear Facilities (CPP), as the amended convention is now known, can play an increasingly important role in efforts to strengthen the international nuclear security architecture. The CPP significantly enhances the international legal framework for nuclear security by expanding the scope of physical protection requirements and providing a direct linkage to International Atomic Energy Agency (IAEA) nuclear security guidance through incorporation of the Fundamental Principles.The CPP’s entry into force requires states parties to submit reports to the IAEA under Article 14 informing the IAEA of its laws and regulations giving effect to the convention—states parties were required to do so under the original CPPNM, but the scope of the reports will need to expand to reflect the expanded scope of the convention. Reporting builds confidence in the effectiveness of states’ security. In addition, entry into force of the CPP requires the IAEA, under Article 16, to convene a review conference in five years to assess the implementation and adequacy of the convention “in light of the then prevailing situation.” The review conference will provide an opportunity for states parties to assess the status of nuclear security progress and will provide a forum for dialogue on how to strengthen the global architecture and address remaining gaps in the system. Article 16 also provides for additional review conferences at periods of at least five years if requested by a majority of states parties. Regular review conferences would be an important mechanism for sustaining attention on nuclear security and ensuring continued nuclear security progress. For the CPP to fulfill its potential to play an important role in

  13. Wolbachia-associated bacterial protection in the mosquito Aedes aegypti.

    Directory of Open Access Journals (Sweden)

    Yixin H Ye

    Full Text Available BACKGROUND: Wolbachia infections confer protection for their insect hosts against a range of pathogens including bacteria, viruses, nematodes and the malaria parasite. A single mechanism that might explain this broad-based pathogen protection is immune priming, in which the presence of the symbiont upregulates the basal immune response, preparing the insect to defend against subsequent pathogen infection. A study that compared natural Wolbachia infections in Drosophila melanogaster with the mosquito vector Aedes aegypti artificially transinfected with the same strains has suggested that innate immune priming may only occur in recent host-Wolbachia associations. This same study also revealed that while immune priming may play a role in viral protection it cannot explain the entirety of the effect. METHODOLOGY/FINDINGS: Here we assess whether the level of innate immune priming induced by different Wolbachia strains in A. aegypti is correlated with the degree of protection conferred against bacterial pathogens. We show that Wolbachia strains wMel and wMelPop, currently being tested for field release for dengue biocontrol, differ in their protective abilities. The wMelPop strain provides stronger, more broad-based protection than wMel, and this is likely explained by both the higher induction of immune gene expression and the strain-specific activation of particular genes. We also show that Wolbachia densities themselves decline during pathogen infection, likely as a result of the immune induction. CONCLUSIONS/SIGNIFICANCE: This work shows a correlation between innate immune priming and bacterial protection phenotypes. The ability of the Toll pathway, melanisation and antimicrobial peptides to enhance viral protection or to provide the basis of malaria protection should be further explored in the context of this two-strain comparison. This work raises the questions of whether Wolbachia may improve the ability of wild mosquitoes to survive pathogen

  14. Conference of University Administrators Conference Proceedings (12th, Surrey, England, March 21-23, 1985).

    Science.gov (United States)

    Conference of Univ. Administrators.

    Conference proceedings for the Conference of University Administrators include summaries of conference sessions, along with Austin Pearce's paper, "The Needs of Industry: What Are They?" Sessions focused on: forming a university company, financial diversification, financial modeling, stock exchange investment and universities, funding of…

  15. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-10-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2015. It was held on Oct.23, 2015 Mayfield Hotel in Seoul, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2015. This proceedings is comprised of 8 sessions. The main topic titles of session are as follows: Radiation protection 1, Medical treatment and Biology 1, Radiation Measurement 1, Radiation environment and disasters prevention 1, Radiation protection 2, Medical treatment and Biology 2, Radiation Measurement 2, Radiation environment and disasters prevention 2.

  16. The 9. European nuclear conference; La 9. conference nucleaire europeenne

    Energy Technology Data Exchange (ETDEWEB)

    Maurel, V.; Lewis, D.; Smirnov, V.P.; Gutierrez, J.E.; Paulin, Ph.; Markov, D.V.; Smirnov, A.V.; Polenok, V.S.; Horhoianu, G.; Olteanu, G.; Van der Schaaf, B.; Gavillet, D.; Lapena, J.; Ohms, C.; Roth, A.; Van Dyck, St.; Mardon, J.P.; Thomas, A.; Cipiere, M.F.; Faidy, C.; Hedin, F.; Delnondedieu, M.; Chassignole, B.; Doudet, L.; Dupond, O.; Kang, K.; Park, K.; Kim, K.; Ha, J.; Hoon-Seok, Jung; Yong-koo, Lee; Kwang-Ho, Kim; Seungwoo, Paek; Heui-Joo, Choi; Do-Hee, Ahn; Kwang-Rag, Kim; Minsoo, Lee; Sung-Paal, Yim; Hongsuk, Chung; Detroux, P.; Meessen, O.; Defloor, J.; Lars-Erik, Holm; Barescut, J.C.; Vacquier, B.; Laurier, D.; Caer, S.; Quesne, B.; Oudalova, A.; Geras' kin, St.; Dikarev, V.; Dikareva, N.; Chernonog, E.; Yang-Geun, Chung; Gab-Bock, Lee; Sun-Young, Bang; Yong-Sun, Lee; Bolognese-Milsztajn, T.; Frank, D.; Lacoste, V.; Pihet, P.; Lacronique, J.F.; Chauliac, C.; Verwaerde, D.; Pavageau, O.; Zaetta, A.; Varaine, F.; Warin, D.; Hudelot, J.P.; Bioux, Ph.; Klann, R.; Petruzzi, A.; D' auria, F.; Yung Kwon, Jin; Chul Jin, Chol; Mihalache, M.; Radu, V.; Pavelescu, M.; Schneidesch, Ch.R.; Jinzhao, Zhang; Dalleur, J.P.; Nuttin, A.; Meplan, O.; Wilson, J.; Perdu, F.; Campioni, G.; Mounier, C.; Sigrist, J.F.; Laine, Ch.; Broc, D.; Robbe, M.F.; Cariou, Y.; Seok-Kyun, Yoon; Win, Naing; Myung-Hyun, Kim; Kyung, Hee; Fridman, E.; Shwageraus, E.; Galperin, A.; Meplan, O.; Laulan, O.; Mechel-Sendis, F.; Belgaid, M.; Kadem, F.; Amokrane, A.; Hamidouche, T.; El-Khider, Si-Ahmed

    2005-11-15

    This issue gathers the abstracts of the papers presented at the ninth European nuclear conference (ENC-2005). The main part of the conference is split into 20 sessions. These sessions cover all technical aspects of nuclear power, from reactor design to waste management, without forgetting experimental and research reactors, reactor dismantling, economy, resources, safety, radioprotection and education issues. Perspectives of a nuclear renaissance are clearly visible in the world. This renaissance, mainly due to political, economical, societal and ecological factors, is fuelled by scientific and technical progress. This conference was the opportunity to present together these aspects of nuclear power and to analyze their mutual interactions.

  17. Conference Report: 5th Annual Georgia Conference on Information Literacy

    Directory of Open Access Journals (Sweden)

    Rebecca Ziegler

    2009-11-01

    Full Text Available The 5th annual Georgia Conference on Information Literacy took place in Savannah, Georgia on October 3-4, 2008. Since its inception, this conference has drawn participants from across the United States and even a few from abroad. Jointly sponsored by the Zach S. Henderson Library, the Department of Writing and Linguistics, the College of Education, and the Center for Continuing Education at Georgia Southern University, the conference offers both theoretical and practical discussions of the complex issues involved in teaching students how to find, interpret and use information in emerging electronic technologies against the backdrop of one of America’s loveliest cities.

  18. Corrosion/96 conference papers

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    Topics covered by this conference include: cathodic protection in natural waters; cleaning and repassivation of building HVAC systems; worldwide opportunities in flue gas desulfurization; advancements in materials technology for use in oil and gas service; fossil fuel combustion and conversion; technology of corrosion inhibitors; computers in corrosion control--modeling and information processing; recent experiences and advances of austenitic alloys; managing corrosion with plastics; corrosion measurement technology; corrosion inhibitors for concrete; refining industry; advances in corrosion control for rail and tank trailer equipment; CO 2 corrosion--mechanisms and control; microbiologically influenced corrosion; corrosion in nuclear systems; role of corrosion in boiler failures; effects of water reuse on monitoring and control technology in cooling water applications; methods and mechanisms of scale and deposit control; corrosion detection in petroleum production lines; underground corrosion control; environmental cracking--relating laboratory results and field behavior; corrosion control in reinforced concrete structures; corrosion and its control in aerospace and military hardware; injection and process addition facilities; progress reports on the results of reinspection of deaerators inspected or repaired per RP0590 criteria; near 100% volume solids coating technology and application methods; materials performance in high temperature environments containing halides; impact of toxicity studies on use of corrosion/scale inhibitors; mineral scale deposit control in oilfield related operations; corrosion in gas treating; marine corrosion; cold climate corrosion; corrosion in the pulp and paper industry; gaseous chlorine alternatives in cooling water systems; practical applications of ozone in recirculating cooling water systems; and water reuse in industry. Over 400 papers from this conference have been processed separately for inclusion on the data base

  19. International Conference Nuclear Energy in Central Europe 99, V. 1. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Gortnar, O; Stritar, A [Nuclear Society of Slovenia (Slovenia)

    1999-07-01

    International Conference Nuclear Energy in Central Europe is an annual meeting of the Nuclear Society of Slovenia. The proceedings contain 101 articles from Slovenia, surrounding countries and countries of the Central and Eastern European Region. Topics are: Reactor Physics, Research Reactors, Thermal Hydraulics, Structural Analysis, Probabilistic Safety Assessment, Severe Accidents, NPP Operation, Nuclear Energy and Public, Radioactive Waste, Radiological Protection and Environmental Issues, Nuclear Methods and Monte Carlo and Deterministic Transport Calculations.

  20. International Conference Nuclear Energy in Central Europe 99, V. 1. Proceedings

    International Nuclear Information System (INIS)

    Gortnar, O.; Stritar, A.

    1999-01-01

    International Conference Nuclear Energy in Central Europe is an annual meeting of the Nuclear Society of Slovenia. The proceedings contain 101 articles from Slovenia, surrounding countries and countries of the Central and Eastern European Region. Topics are: Reactor Physics, Research Reactors, Thermal Hydraulics, Structural Analysis, Probabilistic Safety Assessment, Severe Accidents, NPP Operation, Nuclear Energy and Public, Radioactive Waste, Radiological Protection and Environmental Issues, Nuclear Methods and Monte Carlo and Deterministic Transport Calculations

  1. Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.

    Directory of Open Access Journals (Sweden)

    Nancy J Sullivan

    2006-06-01

    Full Text Available Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or replication-defective adenoviral vectors (rAd encoding the Ebola glycoprotein (GP and nucleoprotein (NP has been previously shown to confer specific protective immunity in nonhuman primates. GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine.To address this question, we have explored the efficacy of mutant GPs from multiple Ebola virus strains with reduced in vitro cytopathicity and analyzed their protective effects in the primate challenge model, with or without NP. Deletion of the GP transmembrane domain eliminated in vitro cytopathicity but reduced its protective efficacy by at least one order of magnitude. In contrast, a point mutation was identified that abolished this cytopathicity but retained immunogenicity and conferred immune protection in the absence of NP. The minimal effective rAd dose was established at 10(10 particles, two logs lower than that used previously.Expression of specific GPs alone vectored by rAd are sufficient to confer protection against lethal challenge in a relevant nonhuman primate model. Elimination of NP from the vaccine and dose reductions to 10(10 rAd particles do not diminish protection and simplify the vaccine, providing the basis for selection of a human vaccine candidate.

  2. Immune Protection of Nonhuman Primates against Ebola Virus with Single Low-Dose Adenovirus Vectors Encoding Modified GPs

    Science.gov (United States)

    Geisbert, Joan B; Shedlock, Devon J; Xu, Ling; Lamoreaux, Laurie; Custers, Jerome H. H. V; Popernack, Paul M; Yang, Zhi-Yong; Pau, Maria G; Roederer, Mario; Koup, Richard A; Goudsmit, Jaap; Jahrling, Peter B; Nabel, Gary J

    2006-01-01

    Background Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or replication-defective adenoviral vectors (rAd) encoding the Ebola glycoprotein (GP) and nucleoprotein (NP) has been previously shown to confer specific protective immunity in nonhuman primates. GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine. Methods and Findings To address this question, we have explored the efficacy of mutant GPs from multiple Ebola virus strains with reduced in vitro cytopathicity and analyzed their protective effects in the primate challenge model, with or without NP. Deletion of the GP transmembrane domain eliminated in vitro cytopathicity but reduced its protective efficacy by at least one order of magnitude. In contrast, a point mutation was identified that abolished this cytopathicity but retained immunogenicity and conferred immune protection in the absence of NP. The minimal effective rAd dose was established at 1010 particles, two logs lower than that used previously. Conclusions Expression of specific GPs alone vectored by rAd are sufficient to confer protection against lethal challenge in a relevant nonhuman primate model. Elimination of NP from the vaccine and dose reductions to 1010 rAd particles do not diminish protection and simplify the vaccine, providing the basis for selection of a human vaccine candidate. PMID:16683867

  3. Major Biomass Conference

    Science.gov (United States)

    Top Scientists, Industry and Government Leaders to Gather for Major Biomass Conference America, South America and Europe will focus on building a sustainable, profitable biomass business at the Third Biomass Conference of the Americas in Montreal. Scheduled presentations will cover all biomass

  4. SRP Meeting: North west regional conference

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, Annette [NNC Limited, Manchester (United Kingdom)

    2002-06-01

    The SRP North West Regional Conference was held in the Education Centre, Christie Hospital NHS Trust in Manchester on the subject of Ionising Regulations 1999 (IRR99) two years on. The Chairman for the morning session was David Abbott from BNFL and for the afternoon was Anne Walker from Christie Hospital. Dr Joanne Nettleton, a HM Principal Specialist Inspector (Radiation) in the Field Operations Directorate, explained the view of the HSE. She outlined that the IRR99 have been in force since January 2000 after a comprehensive consultation exercise. The results that have been seen to date are, not surprisingly, no increase in exposure levels, an increased profile of radiation protection and an improved standing of RPAs. The SRP run a Continuing Professional Development scheme as a personal aid to maintain an adequate level of professionalism, demonstrate competence and as a guide to employers for them to maintain a professional Radiation Protection Service. There are currently over 300 people using the SRPs CPD scheme. They have also detailed a new mentoring system. In conclusion RPA 2000 is successfully meeting the needs of RPAs in the UK and the portfolios of evidence are improving. Overall, the SRP CPD scheme is effective and cheap. David Owen, Radiological Protection Manager responsible for policy and strategy issues in this field, gave a summary of the operation of the BNFL RPA Assessment Scheme, of which he is Secretary to the Management Board. The BNFL RPA Assessment Scheme is recognised by the HSE and has a number of subtle differences from the RPA 2000 scheme. RPAs advise on the restriction of exposure, designation of area, local rules, selection of the RPS, the training of the RPS and other staff, hazard identification, risk assessment, facility design, contingency planning, waste management and transport and any other matters relating to ionising radiation. Becoming an RPA within the medical sector is not easy. Firstly there is two years basic training

  5. SRP Meeting: North west regional conference

    International Nuclear Information System (INIS)

    Kennedy, Annette

    2002-01-01

    The SRP North West Regional Conference was held in the Education Centre, Christie Hospital NHS Trust in Manchester on the subject of Ionising Regulations 1999 (IRR99) two years on. The Chairman for the morning session was David Abbott from BNFL and for the afternoon was Anne Walker from Christie Hospital. Dr Joanne Nettleton, a HM Principal Specialist Inspector (Radiation) in the Field Operations Directorate, explained the view of the HSE. She outlined that the IRR99 have been in force since January 2000 after a comprehensive consultation exercise. The results that have been seen to date are, not surprisingly, no increase in exposure levels, an increased profile of radiation protection and an improved standing of RPAs. The SRP run a Continuing Professional Development scheme as a personal aid to maintain an adequate level of professionalism, demonstrate competence and as a guide to employers for them to maintain a professional Radiation Protection Service. There are currently over 300 people using the SRPs CPD scheme. They have also detailed a new mentoring system. In conclusion RPA 2000 is successfully meeting the needs of RPAs in the UK and the portfolios of evidence are improving. Overall, the SRP CPD scheme is effective and cheap. David Owen, Radiological Protection Manager responsible for policy and strategy issues in this field, gave a summary of the operation of the BNFL RPA Assessment Scheme, of which he is Secretary to the Management Board. The BNFL RPA Assessment Scheme is recognised by the HSE and has a number of subtle differences from the RPA 2000 scheme. RPAs advise on the restriction of exposure, designation of area, local rules, selection of the RPS, the training of the RPS and other staff, hazard identification, risk assessment, facility design, contingency planning, waste management and transport and any other matters relating to ionising radiation. Becoming an RPA within the medical sector is not easy. Firstly there is two years basic training

  6. Proceedings of the International conference on radioecology and environmental radioactivity

    International Nuclear Information System (INIS)

    2008-01-01

    The conference contains 404 presentations on: 1) Emergency preparedness and rehabilitation with emphasis on radiation and radioactivity determination and monitoring, protection and contamination and pollution. 2) TNORM/NORM including radon with focus on radioactivity in the environmental and isotope evaluation. 3) Radioecology and speciation including arctic radioecology, focusing on accidents, radiation and radioactivity effects, nuclear waste disposal, handling, impacts, safety and risks, pollution and its sources, accumulation of isotopes and various medical aspects. 4) Risk assessment with emphasis on the environmental and ecological aspects, modeling, recommendations and international cooperation and discussion of the effects of climatic changes. 5) Radiation in society. 6) Environmental protection with focus on radionuclide studies, radiation effects and protection measures, isotope accumulation effects, nuclide distribution, migration and pollution and effects and handling of nuclear accidents. The global aspects of the topics are evident and there are discussions on non-ionizing and ionizing radiation effect, various simulation problems and public and general health aspects (tk)

  7. The national nuclear technology conference, 6-9 September 1998

    International Nuclear Information System (INIS)

    1998-01-01

    The National nuclear technology conference was held under the aegis of industrial and institutional stake holders from 6 to 9 September 1998 in Mmabatho and hosted by the University of North West. Papers were divided into the following theme clusters: safety, waste management and radiation protection; prospects for nuclear energy generation; applications in mining; applications in industry; medical applications; medical technology and training; agriculture, food security and water resources management; redress, education, research and development; policy and legal framework. The 58 papers were published in summary form only

  8. Environment protection and energy politics

    International Nuclear Information System (INIS)

    Pernice, I.

    1993-01-01

    Three aspects make the issue of energy politics and environment protection in the European Community interesting: Questions of competence, international stipulations, and the concrete measures the Community implements or plans in fulfillment of its duty to integrate these two political spheres. At the international level impulses for an environmentally benign energy policy are given by the World Climate Convention, the Agenda 21 passed at the Rio Conference, and by the European Energy Charter and its consequential documents. (orig./HSCH) [de

  9. ETRAN 2002: Society for Electronics,Telecommunications, Computers, Automation and Nuclear Engineering. Section for Nuclear Techniques and Technology. Proceedings of the XLVI Conference. Vol IV

    International Nuclear Information System (INIS)

    Milosevic, M.; Jaksic, Z.; Bozic, D.; Potkonjak, V.

    2002-01-01

    The XLVI ETRAN Conference of the Society for Electronic, Telecommunications, Computers, Automation and Nuclear Engineering was held on 4-7 June, 2002. In the Proceedings of the Conference The Commission of the Nuclear Technique and Technology has 14 papers presented in three following sessions: 1. Actual problems in nuclear technologies; 2. Accelerator and reactor systems; and 3. Radiation protection and ionizing radiation uses

  10. [4th World Conference on Women].

    Science.gov (United States)

    1995-06-01

    The World Platform of Action is a document prepared by the secretary of the UN Commission on the Status of Women (CSW) that acknowledges commitments made by the subscribing governments. In the final preparatory meeting for the Fourth International Conference on Women in Beijing, official delegations of the world's governments discussed the draft of the Platform of Action. Throughout the Platform, there is evidence of a retreat from concepts internationally recognized at other conferences. The Vatican, in alliance with countries like Honduras, Argentina, and Guatemala, and with fundamentalist religious groups, is largely responsible for the obstruction. The draft indicates which topics have failed to gain consensus and require discussion at the full Conference. The Platform is defined as an agenda for seeking empowerment of women, an objective necessitating removal of obstacles to active participation by women in all spheres of public life. The Platform defines the critical areas for action as the persistent increase in poverty among women, unequal access to education and training, unequal access to health care, violence against women and girls, effects of persecution and armed conflicts, unequal access to productive processes, and unequal power and influence in decision making at all levels. Insufficient mechanisms for promoting women, protection of the human rights of women, women and communication, and women and the environment are other priority topics. Problems are discussed in each of these areas, and objectives and concrete actions are proposed. The work describes the types of institutional changes that will be needed if the objectives are to be achieved; defines sex, gender, and other relevant terms; and analyses some of the strategic objectives in greater detail. The final section contains recommendations for women's groups and other lobbyists in Colombia to present to the government.

  11. Radiation Protection and Civil defence Department

    International Nuclear Information System (INIS)

    Gomaa, M.A.; Elshinawy, R.M.K.; Abdelfattah, A.T.

    1991-01-01

    This conference involves subjects of radiation protection, programming of civil defence, on the implementation of 1990 ICRP recommendation, thermoluminescence properties of bone equivalent calcium phosphate ceramics, potassium body burdens in occupational users of egyptian nuclear research centre, transport of radionuclides in fresh water stream, water treatment process for nuclear reactor, research activities related to internal contamination and bioassay and experience and environmental radiation monitoring in inshass. it contains of figures and tables

  12. 4th European conference on protection against radon at home and at work. Book of abstracts

    International Nuclear Information System (INIS)

    2004-01-01

    The Book of Abstracts contains 91 abstracts of all contributions, presented either in the oral form or in the poster form. In addition to those that had been input to INIS based on the Conference Programme and Presentations (document INIS-CZ-0037), 25 abstracts were selected from this publication for input to INIS. (P.A.)

  13. Conference scene: DGVS spring conference 2009.

    Science.gov (United States)

    Kolligs, Frank Thomas

    2009-10-01

    The 3rd annual DGVS Spring Conference of the German Society for Gastroenterology (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten) was held at the Seminaris Campus Hotel in Berlin, Germany, on 8-9 May, 2009. The conference was organized by Roland Schmid and Matthias Ebert from the Technical University of Munich, Germany. The central theme of the meeting was 'translational gastrointestinal oncology: towards personalized medicine and individualized therapy'. The conference covered talks on markers for diagnosis, screening and surveillance of colorectal cancer, targets for molecular therapy, response prediction in clinical oncology, development and integration of molecular imaging in gastrointestinal oncology and translational research in clinical trial design. Owing to the broad array of topics and limitations of space, this article will focus on biomarkers, response prediction and the integration of biomarkers into clinical trials. Presentations mentioned in this summary were given by Matthias Ebert (Technical University of Munich, Germany), Esmeralda Heiden (Epigenomics, Berlin, Germany), Frank Kolligs (University of Munich, Germany), Florian Lordick (University of Heidelberg, Germany), Hans Jorgen Nielsen (University of Copenhagen, Denmark), Anke Reinacher-Schick (University of Bochum, Germany), Christoph Röcken (University of Berlin, Germany), Wolff Schmiegel (University of Bochum, Germany) and Thomas Seufferlein (University of Halle, Germany).

  14. Resistance to nitrofurantoin and UV-irradiation in recA; uvrA; and uvrA, lexA, Escherichia coli mutants conferred by an R-plasmid from an Escherichia coli clinical isolate

    Energy Technology Data Exchange (ETDEWEB)

    Obaseiki-Ebor, E.E. (Univ. of Benin, Benin City (Nigeria). Faculty of Pharmacy, Dept. of Pharmaceutical Microbiology)

    1984-01-01

    There have been some reports of R-plasmids conferring nitrofuran resistance by decreasing the reduction of nitrofurantoin. The mechanism by which these R-plasmids mediate nitrofurantoin resistance is still not properly understood. Since DNA repair mutants are very sensitive to nitrofurantoin, it was therefore of interest to see whether R-plasmids conferring nitrofurantoin resistance affected the nitrofurantoin sensitivity of recA; uvrA and uvrA, lexA strains of E. coli K-12. Protection against UV-irradiation was also estimated. The experiments showed that the nitrofurantoin resistance conferred by R-plasmid pBN105 was not due to defective nitrofurantoin reduction or altered permeability of the cell. Because it is known that repair-deficient bacteria have increased susceptibility to nitrofurantoin, it may be suggested that the mechanisms of UV and nitrofurantoin protection conferred by pBN105 to the DNA repair mutant strains are related.

  15. Resistance to nitrofurantoin and UV-irradiation in recA; uvrA; and uvrA, lexA, Escherichia coli mutants conferred by an R-plasmid from an Escherichia coli clinical isolate

    International Nuclear Information System (INIS)

    Obaseiki-Ebor, E.E.

    1984-01-01

    There have been some reports of R-plasmids conferring nitrofuran resistance by decreasing the reduction of nitrofurantoin. The mechanism by which these R-plasmids mediate nitrofurantoin resistance is still not properly understood. Since DNA repair mutants are very sensitive to nitrofurantoin, it was therefore of interest to see whether R-plasmids conferring nitrofurantoin resistance affected the nitrofurantoin sensitivity of recA; uvrA and uvrA, lexA strains of E. coli K-12. Protection against UV-irradiation was also estimated. The experiments showed that the nitrofurantoin resistance conferred by R-plasmid pBN105 was not due to defective nitrofurantoin reduction or altered permeability of the cell. Because it is known that repair-deficient bacteria have increased susceptibility to nitrofurantoin, it may be suggested that the mechanisms of UV and nitrofurantoin protection conferred by pBN105 to the DNA repair mutant strains are related. (Auth.)

  16. 9. Arab conference on the peaceful uses of atomic energy, Beirut (LB), 13-16 Dec 2008, V. I

    International Nuclear Information System (INIS)

    2009-01-01

    This volume includes the papers presented at the 9th Arab Conference on the Peaceful Uses of Atomic Energy, held at Beirut (Lebanon) from 13 till 16 December 2008, which cover isotope applications on biology and medicine, environmental pollution, radiation protection.

  17. Mendel conference

    CERN Document Server

    2015-01-01

    This book is a collection of selected accepted papers of Mendel conference that has been held in Brno, Czech Republic in June 2015. The book contents three chapters which represent recent advances in soft computing including intelligent image processing and bio-inspired robotics.: Chapter 1: Evolutionary Computing, and Swarm intelligence, Chapter 2: Neural Networks, Self-organization, and Machine Learning, and Chapter3: Intelligent Image Processing, and Bio-inspired Robotics. The Mendel conference was established in 1995, and it carries the name of the scientist and Augustinian priest Gregor J. Mendel who discovered the famous Laws of Heredity. In 2015 we are commemorating 150 years since Mendel's lectures, which he presented in Brno on February and March 1865. The main aim of the conference was to create a periodical possibility for students, academics and researchers to exchange their ideas and novel research methods.  .

  18. First Virtual Live Conference in Healthcare.

    Science.gov (United States)

    Parthasarathi, Ramakrishnan; Gomes, Rachel M; Palanivelu, Praveen Raj; Senthilnathan, Palanisamy; Rajapandian, Subbiah; Venkatachalam, Ramasamy; Palanivelu, Chinnusamy

    2017-07-01

    Conferences and meetings bring together thousands of doctors from diverse locations. However, the traveling, accommodation, and arrangement of venues for conferences and meetings are expensive and a lot of time needs to be devoted to these logistics. The purpose of this article was to present our own virtual live conference experience using web conferencing and to briefly outline the basics and advantages of this technology in organization of healthcare conferences. Web conferencing technology was used to organize an international bariatric surgery conference, allowing a large number of attendees to participate and interact from wherever they were, using merely an Internet connection with a video player on their personal computers, laptops, or smartphones. A virtual live conference saves a lot of time and cost and simplifies the logistics needed to organize a learning conference with worldwide participation. As far as we know, this is the first report of a virtual live conference in healthcare. We see it as the future of organizing experts as well as medical teaching conferences.

  19. 2nd Bozeman Conference

    CERN Document Server

    Lund, John

    1991-01-01

    This volume contains a collection of papers delivered by the partici­ pants at the second Conference on Computation and Control held at Mon­ tana State University in Bozeman, Montana from August 1-7, 1990. The conference, as well as this proceedings, attests to the vitality and cohesion between the control theorist and the numerical analyst that was adver­ tised by the first Conference on Computation and Control in 1988. The proceedings of that initial conference was published by Birkhiiuser Boston as the first volume of this same series entitled Computation and Control, Proceedings of the Bozeman Conference, Bozeman, Montana, 1988. Control theory and numerical analysis are both, by their very nature, interdisciplinary subjects as evidenced by their interaction with other fields of mathematics and engineering. While it is clear that new control or es­ timation algorithms and new feedback design methodologies will need to be implemented computationally, it is likewise clear that new problems in computation...

  20. QCD@LHC International Conference

    CERN Document Server

    2016-01-01

    The particle physics groups of UZH and ETH will host the QCD@LHC2016 conference (22.8.-26.8., UZH downtown campus), which is part of an annual conference series bringing together theorists and experimentalists working on hard scattering processes at the CERN LHC, ranging from precision studies of Standard Model processes to searches for new particles and phenomena. The format of the conference is a combination of plenary review talks and parallel sessions, with the latter providing a particularly good opportunity for junior researchers to present their results. The conference will take place shortly after the release of the new data taken by the LHC in sping 2016 at a collision energy of 13TeV, expected to more than double the currently available data set. It will be one of the first opportunities to discuss these data in a broader context, and we expect the conference to become a very lively forum at the interface of phenomenology and experiment.

  1. Declining Enrollment. An NSBA Conference (Colorado Springs, Colorado, August 4-6, 1976). Conference Report.

    Science.gov (United States)

    Florio, David H.

    This report results from a National School Boards Association (NSBA) conference on declining enrollment and from a survey of state school boards associations conducted in advance of the conference. The conference drew school board leaders and school administrators together with population experts to achieve several purposes that are reflected in…

  2. 10th Conference on Bayesian Nonparametrics

    Science.gov (United States)

    2016-05-08

    RETURN YOUR FORM TO THE ABOVE ADDRESS. North Carolina State University 2701 Sullivan Drive Admin Srvcs III, Box 7514 Raleigh, NC 27695 -7514 ABSTRACT...the conference. The findings from the conference is widely disseminated. The conference web site displays slides of the talks presented in the...being published by the Electronic Journal of Statistics consisting of about 20 papers read at the conference. The conference web site displays

  3. CONFERENCE: Computers and accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1984-01-15

    In September of last year a Conference on 'Computers in Accelerator Design and Operation' was held in West Berlin attracting some 160 specialists including many from outside Europe. It was a Europhysics Conference, organized by the Hahn-Meitner Institute with Roman Zelazny as Conference Chairman, postponed from an earlier intended venue in Warsaw. The aim was to bring together specialists in the fields of accelerator design, computer control and accelerator operation.

  4. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Spring Meeting 2017

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-04-15

    This proceedings contains articles of the Korean Association for Radiation Protection Spring Meeting, 2017. It was held on 13 April 2017 Gunsan Saemangeum Covention Center in Gunsan, Korea and subject of the Korean Association for Radiation Protection Spring Meeting 2017. This proceedings is comprised of 5 ssessions. The main topic titles of session are as follows: Radiation protection, Biotechnology of radiation, Radiation measurement and prevention, Radiation epidemiography.

  5. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-12-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2016. It was held on Dec. 1, 2016 Phoenix Island in Jeju, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2016. This proceedings is comprised of 5 sessions. The main topic titles of session are as follows: Radiation protection, Biotechnology of radiation, Radiation measurement, Radiation environment and prevention, Radiation epidemiography.

  6. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Spring Meeting 2017

    International Nuclear Information System (INIS)

    2017-04-01

    This proceedings contains articles of the Korean Association for Radiation Protection Spring Meeting, 2017. It was held on 13 April 2017 Gunsan Saemangeum Covention Center in Gunsan, Korea and subject of the Korean Association for Radiation Protection Spring Meeting 2017. This proceedings is comprised of 5 ssessions. The main topic titles of session are as follows: Radiation protection, Biotechnology of radiation, Radiation measurement and prevention, Radiation epidemiography.

  7. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Spring Meeting 2016

    International Nuclear Information System (INIS)

    2016-04-01

    This proceedings contains articles of the Korean Association for Radiation Protection Spring Meeting, 2016. It was held on Apr. 6-8, 2016 Daemyung Resort in Byeonsan, Korea and subject of the Korean Association for Radiation Protection Spring Meeting 2016. This proceedings is comprised of 4 sessions. The main topic titles of session are as follows: Radiation protection, Biotechnology of radiation, Radiation Measurement, Radiation environment and prevention

  8. Hosting an eConference: Interactive video conference grand rounds between two institutions

    Directory of Open Access Journals (Sweden)

    Jeffrey Rixe

    2018-01-01

    Full Text Available Audience: The eConference is an interactive video conference grand rounds innovation to augment the didactic curriculum provided for medical students, interns, residents, fellows, and attending physicians. Introduction: Formal education during emergency medicine (EM training has historically emphasized aspects of humanism and constructivism; the former through self-directed reading in books and journals, the latter through the content and discussion during resident didactics.1 However, some studies suggest that the current generation of EM learners are increasingly using digital and internet technologies to connect with online peer networks, a phenomenon known as connectivism.2 As such, contemporary EM learners are increasingly utilizing social media and Free Open Access Medical Education (FOAM to supplement traditional learning resources. The eConference was developed to be an interactive, virtual grand rounds that marries the merits of constructivism with connectivism; a new format of EM didactics that goes beyond the “typical lecture” model to incorporate the changing landscape in technology and medical education by combining classroom teaching at multiple institutions alongside digital learning tools. This manuscript outlines how to plan and execute a joint video conference with another institution. Objectives: Our objectives were to create and implement a novel virtual conference format through the integration of social media tools which allows for interdisciplinary and multi-site participation to enhance EM resident education. We wish to outline the steps required to reproduce this innovative session and share lessons learned. Conclusion: We designed and executed a multi-centered, novel form of virtual conference into the EM residency curriculum at two participating institutions. The virtual conference took place during a routine conference day for both programs, an hour in duration. The format utilized a hybrid of live and virtual

  9. Male killing Spiroplasma protects Drosophila melanogaster against two parasitoid wasps

    Science.gov (United States)

    Xie, J; Butler, S; Sanchez, G; Mateos, M

    2014-01-01

    Maternally transmitted associations between endosymbiotic bacteria and insects are diverse and widespread in nature. Owing to imperfect vertical transmission, many heritable microbes have evolved compensational mechanisms to enhance their persistence in host lineages, such as manipulating host reproduction and conferring fitness benefits to host. Symbiont-mediated defense against natural enemies of hosts is increasingly recognized as an important mechanism by which endosymbionts enhance host fitness. Members of the genus Spiroplasma associated with distantly related Drosophila hosts are known to engage in either reproductive parasitism (i.e., male killing) or defense against natural enemies (the parasitic wasp Leptopilina heterotoma and a nematode). A male-killing strain of Spiroplasma (strain Melanogaster Sex Ratio Organism (MSRO)) co-occurs with Wolbachia (strain wMel) in certain wild populations of the model organism Drosophila melanogaster. We examined the effects of Spiroplasma MSRO and Wolbachia wMel on Drosophila survival against parasitism by two common wasps, Leptopilina heterotoma and Leptopilina boulardi, that differ in their host ranges and host evasion strategies. The results indicate that Spiroplasma MSRO prevents successful development of both wasps, and confers a small, albeit significant, increase in larva-to-adult survival of flies subjected to wasp attacks. We modeled the conditions under which defense can contribute to Spiroplasma persistence. Wolbachia also confers a weak, but significant, survival advantage to flies attacked by L. heterotoma. The host protective effects exhibited by Spiroplasma and Wolbachia are additive and may provide the conditions for such cotransmitted symbionts to become mutualists. Occurrence of Spiroplasma-mediated protection against distinct parasitoids in divergent Drosophila hosts suggests a general protection mechanism. PMID:24281548

  10. [White House Conference on Aging, 1981: Reports of the Mini-Conferences, MCR 1-42.

    Science.gov (United States)

    White House Conference on Aging, Washington, DC.

    This document contains the 42 reports from mini-conferences held in various nationwide locations prior to the 1981 White House Conference on Aging. Each report presents an overview of the topic, descriptions of particular problems, and statements of recommendations, based on the views of mini-conference participants, and made available to the…

  11. Computational Intelligence : International Joint Conference

    CERN Document Server

    Dourado, António; Rosa, Agostinho; Filipe, Joaquim; Kacprzyk, Janusz

    2016-01-01

    The present book includes a set of selected extended papers from the fifth International Joint Conference on Computational Intelligence (IJCCI 2013), held in Vilamoura, Algarve, Portugal, from 20 to 22 September 2013. The conference was composed by three co-located conferences:  The International Conference on Evolutionary Computation Theory and Applications (ECTA), the International Conference on Fuzzy Computation Theory and Applications (FCTA), and the International Conference on Neural Computation Theory and Applications (NCTA). Recent progresses in scientific developments and applications in these three areas are reported in this book. IJCCI received 111 submissions, from 30 countries, in all continents. After a double blind paper review performed by the Program Committee, only 24 submissions were accepted as full papers and thus selected for oral presentation, leading to a full paper acceptance ratio of 22%. Additional papers were accepted as short papers and posters. A further selection was made after ...

  12. Isotopes in environmental studies - Aquatic Forum 2004. Proceedings of an international conference. Unedited papers

    International Nuclear Information System (INIS)

    2006-01-01

    A better understanding of key processes in the aquatic environment, responsible for its future development and its protection, were at the forefront of the IAEA's International Conference on Isotopes in Environmental Studies - AQUATIC FORUM 2004 convened in Monaco from 25 to 29 October 2004, which was the most important gathering of the year of isotope environmental scientists. Over 320 experts from 60 IAEA Member States and 6 international organizations delivered 185 oral presentations in 6 plenary and 31 parallel sessions and made 130 poster presentations. The conference reviewed the present state of the art isotopic methods for investigation of the aquatic environment. The main conference subjects considered were: (i) behaviour, transport and distribution of isotopes in the aquatic environment; (ii) climate change studies using isotopic records in the marine environment; (iii) groundwater dynamics, modelling and management of freshwater sources; (iv) important global projects, such as WOCE, WOMARS, SHOTS, GEOTRACES; (v) joint IAEA-UNESCO submarine groundwater investigations in the Mediterranean Sea, the Southwest Atlantic and Pacific Oceans; (vi) new trends in radioecological investigations, concentrating on the protection of marine biota against radioactive contamination; (vii) transfers in analytical technologies from bulk analyses to particle and compound specific analyses of environmental samples; (viii) development of new isotopic techniques, such as AMS and ICPMS, and their successful applications in environmental studies; and many other exciting topics which were presented and discussed during the Conference. Four workshops were held simultaneously: - ATOMS-Med Workshop - development of a project proposal for oceanographic investigations in the Eastern Mediterranean. - El Nino - Research Co-ordination Meeting of the new IAEA Coordinated Research Project investigating climate change using isotopic records in the marine environment. - CELLAR Workshop

  13. Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells.

    Directory of Open Access Journals (Sweden)

    Jae Myung Park

    Full Text Available Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1 or UVRAG can regulate the DNA damage/repair response to cancer treatment in established tumor cells. We found that siRNA knockdown of Beclin 1 or UVRAG can increase radiation-induced DNA double strand breaks (DSBs, shown by pATM and γH2Ax, and promote colorectal cancer cell death. Furthermore, knockdown of Beclin 1, UVRAG or ATG5 increased the percentage of irradiated cells with nuclear foci expressing 53BP1, a marker of nonhomologous end joining but not RAD51 (homologous recombination, compared to control siRNA. Beclin 1 siRNA was shown to attenuate UVRAG expression. Cells with a UVRAG deletion mutant defective in Beclin 1 binding showed increased radiation-induced DSBs and cell death compared to cells with ectopic wild-type UVRAG. Knockdown of Beclin 1 or UVRAG, but not ATG5, resulted in a significant increase in centrosome number (γ-tubulin staining in irradiated cells compared to control siRNA. Taken together, these data indicate that Beclin 1 and UVRAG confer protection against radiation-induced DNA DSBs and may maintain centrosome stability in established tumor cells.

  14. Annual International DIC Society Conference and SEM Fall Conference

    CERN Document Server

    Reu, Phillip

    2017-01-01

    This collection represents a single volume of technical papers presented at the Annual International DIC Society Conference and SEM Fall Conference organized by the Society for Experimental Mechanics and Sandia National Laboratories and held in Philadelphia, PA, November 7-10, 2016. The volume presents early findings from experimental, standards development and various other investigations concerning digital image correlation - an important area within Experimental Mechanics. The area of Digital Image Correlation has been an integral track within the SEM Annual Conference spearheaded by Professor Michael Sutton from the University of South Carolina. In 2016, the SEM and Sandia joined their collaborative strengths to launch a standing fall meeting focusing specifically on developments in the area of Digital Image Correlation. The contributed papers within this volume span numerous technical aspects of DIC including standards development for the industry. .

  15. Pertussis Maternal Immunization: Narrowing the Knowledge Gaps on the Duration of Transferred Protective Immunity and on Vaccination Frequency

    Directory of Open Access Journals (Sweden)

    María Emilia Gaillard

    2017-09-01

    Full Text Available Maternal safety through pertussis vaccination and subsequent maternal–fetal-antibody transfer are well documented, but information on infant protection from pertussis by such antibodies and by subsequent vaccinations is scarce. Since mice are used extensively for maternal-vaccination studies, we adopted that model to narrow those gaps in our understanding of maternal pertussis immunization. Accordingly, we vaccinated female mice with commercial acellular pertussis (aP vaccine and measured offspring protection against Bordetella pertussis challenge and specific-antibody levels with or without revaccination. Maternal immunization protected the offspring against pertussis, with that immune protection transferred to the offspring lasting for several weeks, as evidenced by a reduction (4–5 logs, p < 0.001 in the colony-forming-units recovered from the lungs of 16-week-old offspring. Moreover, maternal-vaccination-acquired immunity from the first pregnancy still conferred protection to offspring up to the fourth pregnancy. Under the conditions of our experimental protocol, protection to offspring from the aP-induced immunity is transferred both transplacentally and through breastfeeding. Adoptive-transfer experiments demonstrated that transferred antibodies were more responsible for the protection detected in offspring than transferred whole spleen cells. In contrast to reported findings, the protection transferred was not lost after the vaccination of infant mice with the same or other vaccine preparations, and conversely, the immunity transferred from mothers did not interfere with the protection conferred by infant vaccination with the same or different vaccines. These results indicated that aP-vaccine immunization of pregnant female mice conferred protective immunity that is transferred both transplacentally and via offspring breastfeeding without compromising the protection boostered by subsequent infant vaccination. These results

  16. Proceedings of second JAERI-JNC joint conference on nuclear safety research

    International Nuclear Information System (INIS)

    Sugimoto, Jun; Anoda, Yoshinari; Araya, Fumimasa; Yamaguchi, Toshio

    2004-08-01

    The second JAERI-JNC Joint Conference on Nuclear Safety Research was held on February 6, 2004 in Tokyo for those who are relevant to nuclear industries and regulatory organizations, and general public. The nuclear safety research has been conducted in both institutes according to the Five-Year Program for Nuclear Safety Research established periodically by the Nuclear Safety Commission (NSC) and needs from the regulatory organizations. The objectives of the conference are to present its recent results and to collect views and opinions from the participants for its future program through the discussion after each presentation and panel discussion on how to conduct efficiently the nuclear safety in the New Organization. A total of 259 people participated in the conference mainly from the nuclear industries and regulatory organizations and the number was much larger than that in the last conference of 188. The conference consisted of presentations on the safety research results, a special lecture and a panel discussion. First, the overview of safety research results was presented from each institute. Then, the results in the field of nuclear installations, environmental radioactivity and radioactive waste were presented from each institute. Then, Dr. Higashi, the Nuclear Safety Commissioner, made a special lecture on the radiation protection from the high-level radioactive waste disposal. Finally, a panel discussion was conducted with the title of ''how to conduct efficiently the nuclear safety research in the New Organization'' chaired by Prof. Kimura, the chairperson of Standing Committee on Nuclear Safety Research under the NSC. The panelists from the regulatory organizations, nuclear industry, JAERI and JNC discussed the subject together with the participants on the floor. The panelists not from JAERI and JNC expressed their views and opinions on how to conduct efficiently the nuclear safety research in the New Organization that were valuable inputs for developing

  17. Radiation Protection Institute Annual Report for 2013

    International Nuclear Information System (INIS)

    2013-01-01

    The report covers the activities of the Radiation Protection Institute (RPI) of the Ghana Atomic Energy Commission for the year 2013. The report is grouped under the following headings: establishment, vision and mission; personnel and organization; major activities and research projects; IAEA, Technical Cooperation and AFRA projects; ongoing research projects and programs; income and expenditure statements, physical development and human resource development, training courses, meetings and conferences. (A. B.)

  18. Dress Codes and the Academic Conference: McCulloch's Iron Laws of Conferences

    Science.gov (United States)

    McCulloch, Alistair

    2018-01-01

    Despite being a staple of academic life (or perhaps because it is so taken-for-granted), the academic conference has been generally under-utilised as a site for academic research. Using participant observation as its methodology, this article draws on a long career of conference attendance to present two iron laws of conferences which address the…

  19. Topics in Number Theory Conference

    CERN Document Server

    Andrews, George; Ono, Ken

    1999-01-01

    From July 31 through August 3,1997, the Pennsylvania State University hosted the Topics in Number Theory Conference. The conference was organized by Ken Ono and myself. By writing the preface, I am afforded the opportunity to express my gratitude to Ken for beng the inspiring and driving force behind the whole conference. Without his energy, enthusiasm and skill the entire event would never have occurred. We are extremely grateful to the sponsors of the conference: The National Sci­ ence Foundation, The Penn State Conference Center and the Penn State Depart­ ment of Mathematics. The object in this conference was to provide a variety of presentations giving a current picture of recent, significant work in number theory. There were eight plenary lectures: H. Darmon (McGill University), "Non-vanishing of L-functions and their derivatives modulo p. " A. Granville (University of Georgia), "Mean values of multiplicative functions. " C. Pomerance (University of Georgia), "Recent results in primality testing. " C. ...

  20. PREFACE: Quark Matter 2006 Conference

    Science.gov (United States)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14 20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  1. Breaking ground creating a greener, healthier city : conference proceedings

    International Nuclear Information System (INIS)

    2004-01-01

    This regional conference focused on urban green space issues with recommendations for new directions and strategic actions for A greener, healthier urban community. The conference theme was a green infrastructure for Calgary, which includes benefits such as less automobile emissions and improved public health. Urban land trusts were also examined as protection and acquisition tools. Participants submitted a recommendation to create a task force to examine water management with emphasis on adopting a watershed approach to water systems. Other topics of discussion included the greening of urban village parks as a vital ecological component to urban settings. Innovative techniques to make use of open space as Calgary grows, were also presented. The green infrastructure framework is based on minimizing the consumption of essential natural assets while developing a more efficient use of urban space. The pattern of growth is more significant than the amount of growth in determining the level and efficiency of resource use and traffic congestion. The many opportunities, incentives and obstacles to sustainable development were presented. refs., figs

  2. Report on the Austrian Mining Conference 1981

    Energy Technology Data Exchange (ETDEWEB)

    Steinmetz, R

    1982-02-01

    The conference took place in Leoben from 19 to 22 May, 1981, under the auspices of the Montanuniversitaet Leoben and the Bergmaennischer Verband of Austria. A total of 14 talks were held, which are summarized in brief. Main topics of the talks concerned prospects of the international coal industry, concepts of Austria' energy supply, coal exploration in Austria, uranium reserves of Austria, development of international coal trade, brown coal deposits of Hungary, aspects of overburden removal in surface mines and of roadway drivage in underground mines, prediction of rock behavior in deep mines, hydraulic salt mining, and protection of an iron ore preparation plant in India by the Austrian VOEST-ALPINE AG. (In German)

  3. Sakharov readings 2013: environmental problems of the XXI century. Proceedings of the 13 international scientific conference

    International Nuclear Information System (INIS)

    Kundas, S.P.; Poznyak, S.S.; Lysukho, N.A.

    2013-05-01

    The proceeding includes materials of reports of 13-th international scientific conference 'Sakharov readings 2013: Environmental problems of XXI century', which took place 16-17 of May 2013 in the International A. Sakharov Environmental University (Minsk, Belarus). The proceeding continues abstracts about social-ecological and ecology-ethical problems of modern times; education for sustainable development; medical ecology; biological ecology; radiobiology; radioecology and radiation protection; information systems and technologies in ecology and medicine; regional ecological problems; ecological monitoring and management; renewable energy sources and energy efficiency. Materials of the conference intend on wide area of the specialists in ecology and adjacent sciences, teachers, post-graduate students and students of universities and colleges.

  4. Indico CONFERENCE: Define the Programme

    CERN Multimedia

    CERN. Geneva; Ferreira, Pedro

    2017-01-01

    In this tutorial you are going to learn how to define the programme of a conference in Indico. The program of your conference is divided in different “tracks”. Tracks represent the subject matter of the conference, such as “Online Computing”, “Offline Computing”, and so on.

  5. A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria.

    Directory of Open Access Journals (Sweden)

    Frédéric Coutant

    Full Text Available Trials testing the RTS,S candidate malaria vaccine and radiation-attenuated sporozoites (RAS have shown that protective immunity against malaria can be induced and that an effective vaccine is not out of reach. However, longer-term protection and higher protection rates are required to eradicate malaria from the endemic regions. It implies that there is still a need to explore new vaccine strategies. Lentiviral vectors are very potent at inducing strong immunological memory. However their integrative status challenges their safety profile. Eliminating the integration step obviates the risk of insertional oncogenesis. Providing they confer sterile immunity, nonintegrative lentiviral vectors (NILV hold promise as mass pediatric vaccine by meeting high safety standards. In this study, we have assessed the protective efficacy of NILV against malaria in a robust pre-clinical model. Mice were immunized with NILV encoding Plasmodium yoelii Circumsporozoite Protein (Py CSP and challenged with sporozoites one month later. In two independent protective efficacy studies, 50% (37.5-62.5 of the animals were fully protected (p = 0.0072 and p = 0.0008 respectively when compared to naive mice. The remaining mice with detectable parasitized red blood cells exhibited a prolonged patency and reduced parasitemia. Moreover, protection was long-lasting with 42.8% sterile protection six months after the last immunization (p = 0.0042. Post-challenge CD8+ T cells to CSP, in contrast to anti-CSP antibodies, were associated with protection (r = -0.6615 and p = 0.0004 between the frequency of IFN-g secreting specific T cells in spleen and parasitemia. However, while NILV and RAS immunizations elicited comparable immunity to CSP, only RAS conferred 100% of sterile protection. Given that a better protection can be anticipated from a multi-antigen vaccine and an optimized vector design, NILV appear as a promising malaria vaccine.

  6. Ischemic preconditioning fails to confer additional protection against ischemia-reperfusion injury in the hypothyroid rat heart.

    Science.gov (United States)

    Mourouzis, I; Dimopoulos, A; Saranteas, T; Tsinarakis, N; Livadarou, E; Spanou, D; Kokkinos, A D; Xinaris, C; Pantos, C; Cokkinos, D V

    2009-01-01

    There is accumulating evidence showing that ischemic preconditioning (PC) may lose its cardioprotective effect in the diseased states. The present study investigated whether PC can be effective in hypothyroidism, a clinical condition which is common and often accompanies cardiac diseases such as heart failure and myocardial infarction. Hypothyroidism was induced in rats by 3-week administration of 6n-propyl-2-thiouracil in water (0.05 %). Normal and hypothyroid hearts (HYPO) were perfused in Langendorff mode and subjected to 20 min of zero-flow global ischemia and 45 min of reperfusion. A preconditioning protocol (PC) was also applied prior to ischemia. HYPO hearts had significantly improved post-ischemic recovery of left ventricular developed pressure, end-diastolic pressure and reduced lactate dehydrogenase release. Furthermore, phospho-JNK and p38 MAPK levels after ischemia and reperfusion were 4.0 and 3.0 fold lower in HYPO as compared to normal hearts (Phearts. PC improved the post-ischemic recovery of function and reduced the extent of injury in normal hearts but had no additional effect on the hypothyroid hearts. This response, in the preconditioned normal hearts, resulted in 2.5 and 1.8 fold smaller expression of the phospho-JNK and phospho-p38 MAPK levels at the end of reperfusion, as compared to non-PC hearts (Phearts, no additional reduction in the phosphorylation of these kinases was observed after PC. Hypothyroid hearts appear to be tolerant to ischemia-reperfusion injury. This response may be, at least in part, due to the down-regulation of ischemia-reperfusion induced activation of JNKs and p38 MAPK kinases. PC is not associated with further reduction in the activation of these kinases in the hypothyroid hearts and fails to confer added protection in those hearts.

  7. 76 FR 60017 - Technical Conference on Penalty Guidelines; Notice of Technical Conference on Penalty Guidelines

    Science.gov (United States)

    2011-09-28

    ... Conference on Penalty Guidelines; Notice of Technical Conference on Penalty Guidelines The staff of the... the Penalty Guidelines, which the Commission issued on September 17, 2010.\\1\\ The conference will be... impact of the Penalty Guidelines on compliance and enforcement matters. More information on the topics to...

  8. Sakharov readings 2011: environmental problems of the XXI century. Proceedings of 11 international scientific conference

    International Nuclear Information System (INIS)

    Kundas, S.P.; Poznyak, S.S.

    2011-05-01

    The proceeding includes materials of reports of 11-th international scientific conference 'Sakharov readings 2011: Environmental problems of XXI century', which took place 19-20 of May 2011 in the International A. Sakharov Environmental University. The proceeding continues abstracts about social-ecological, ecology-ethical and pedagogical problems in light of the Sakharov' ideas; medical ecology; biological ecology; biomonitoring, bioindication and bioremediation; radioecology and radiation protection; information systems and technologies in ecology and medicine; ecological monitoring, management and audit; renewable energy sources and energy efficiency; climate change and sustainable development; regional ecological problems. Materials of the conference intend on wide area of the specialists in ecology and adjacent sciences, teachers, post-graduate students and students of universities and colleges.

  9. Microbicides 2006 conference

    Directory of Open Access Journals (Sweden)

    McGowan Ian

    2006-10-01

    Full Text Available Abstract Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible options for women due to various socio-economic and cultural factors. Microbicides are products designed to be inserted in the vagina or rectum prior to sex to prevent HIV acquisition. The biannual Microbicides conference took place in Cape Town, South Africa from 23–26 April 2006. The conference was held for the first time on the African continent, the region worst affected by the HIV/AIDS pandemic. The conference brought together a record number of 1,300 scientists, researchers, policy makers, healthcare workers, communities and advocates. The conference provided an opportunity for an update on microbicide research and development as well as discussions around key issues such as ethics, acceptability, access and community involvement. This report discusses the current status of microbicide research and development, encompassing basic and clinical science, social and behavioural science, and community mobilisation and advocacy activities.

  10. 4th International Cryocoolers Conference

    CERN Document Server

    Patton, George; Knox, Margaret

    1987-01-01

    The Cryocoolers 4 proceedings archives the contributions of leading international experts at the 4th International Cryocooler Conference that was held in Easton, Maryland on September 25-26, 1986. About 170 people attended the conference representing 11 countries, 14 universities, 21 government laboratories and 60 industrial companies. Thirty-one papers were presented describing advancements and applications of cryocoolers in the temperature range below 80K. This year's conference was sponsored by the David Taylor Naval Ship Research and Development Center of Annapolis, Maryland, and the conference proceedings reproduced here was published by them.

  11. Transgenic strategies to confer resistance against viruses in rice plants

    Directory of Open Access Journals (Sweden)

    Takahide eSasaya

    2014-01-01

    Full Text Available Rice (Oryza sativa L. is cultivated in more than 100 countries and supports nearly half of the world’s population. Developing efficient methods to control rice viruses is thus an urgent necessity because viruses cause serious losses in rice yield. Most rice viruses are transmitted by insect vectors, notably planthoppers and leafhoppers. Viruliferous insect vectors can disperse their viruses over relatively long distances, and eradication of the viruses is very difficult once they become widespread. Exploitation of natural genetic sources of resistance is one of the most effective approaches to protect crops from virus infection; however, only a few naturally occurring rice genes confer resistance against rice viruses. In an effort to improve control, many investigators are using genetic engineering of rice plants as a potential strategy to control viral diseases. Using viral genes to confer pathogen-derived resistance against crops is a well-established procedure, and the expression of various viral gene products has proved to be effective in preventing or reducing infection by various plant viruses since the 1990s. RNA-interference (RNAi, also known as RNA silencing, is one of the most efficient methods to confer resistance against plant viruses on their respective crops. In this article, we review the recent progress, mainly conducted by our research group, in transgenic strategies to confer resistance against tenuiviruses and reoviruses in rice plants. Our findings also illustrate that not all RNAi constructs against viral RNAs are equally effective in preventing virus infection and that it is important to identify the viral Achilles’ heel gene to target for RNAi attack when engineering plants.

  12. An initial examination of the potential role of T-cell immunity in protection against feline immunodeficiency virus (FIV) infection.

    Science.gov (United States)

    Aranyos, Alek M; Roff, Shannon R; Pu, Ruiyu; Owen, Jennifer L; Coleman, James K; Yamamoto, Janet K

    2016-03-14

    The importance of vaccine-induced T-cell immunity in conferring protection with prototype and commercial FIV vaccines is still unclear. Current studies performed adoptive transfer of T cells from prototype FIV-vaccinated cats to partial-to-complete feline leukocyte antigen (FLA)-matched cats a day before either homologous FIVPet or heterologous-subtype pathogenic FIVFC1 challenge. Adoptive-transfer (A-T) conferred a protection rate of 87% (13 of 15, p 13 × 10(6) cells were required for A-T protection against FIVFC1 strain, reported to be a highly pathogenic virus resistant to vaccine-induced neutralizing-antibodies. The addition of FLA-matched B cells alone was not protective. The poor quality of the anti-FIV T-cell immunity induced by the vaccine likely contributed to the lack of protection in an FLA-matched recipient against FIVFC1. The quality of the immune response was determined by the presence of high mRNA levels of cytolysin (perforin) and cytotoxins (granzymes A, B, and H) and T helper-1 cytokines (interferon-γ [IFNγ] and IL2). Increased cytokine, cytolysin and cytotoxin production was detected in the donors which conferred protection in A-T studies. In addition, the CD4(+) and CD8(+) T-cell proliferation and/or IFNγ responses to FIV p24 and reverse transcriptase increased with each year in cats receiving 1X-3X vaccine boosts over 4 years. These studies demonstrate that anti-FIV T-cell immunity induced by vaccination with a dual-subtype FIV vaccine is essential for prophylactic protection against AIDS lentiviruses such as FIV and potentially HIV-1. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. 86th Annual Georgia Public Health Association Meeting & Conference Report.

    Science.gov (United States)

    Smith, Selina A; Abbott, Regina; Sims, Christy

    2015-01-01

    The 86 th annual meeting of the Georgia Public Health Association (GPHA) and joint conference with the Southern Health Association was held in Atlanta, Georgia, on April 13-14, 2015, with pre-conference (April 12 th ) and post-conference (April 14 th ) Executive Board meetings. As Georgia's leading forum for public health researchers, practitioners, and students, the annual meeting of the GPHA brings together participants from across the state to explore recent developments in the field and to exchange techniques, tools, and experiences. Historically, the GPHA conference has been held in Savannah (n=24); Jekyll Island (n=20); Atlanta (n=16); Augusta (n=4); and Gainesville (n=1). There was no annual meeting during the early years (1929-1936); during World War II (1941-1943 and 1945); and for four years during the 1980s. Between 2006 and 2010, GPHA held one-day annual meetings and business sessions with educational workshops. Several new initiatives were highlighted as part of this year's conference. These included a "move and groove" physical activity lounge, registration scholarships for students with a dedicated meet-and-greet reception, an expanded exhibit hall, presentation and approval of three resolutions (related to healthy foods at official activities and events; weapons at official activities and events; and memorials), and approval of the 2015 legislative policy positions and amended association bylaws. The theme for the conference was Advocacy in Action for Public Health . Specifically, the program addressed ensuring access to care; protecting funding for core programs, services, and infrastructure; eliminating health disparities; and addressing key public health issues important to the state of Georgia. One hundred and nine (109) abstracts were submitted for peer review; 36 were accepted for poster and 40 for workshop presentations. Four plenary sessions with keynote speakers covered the intersection between advocacy and policy, Georgia's response to the

  14. Radiation protection for humans and environment. 50 years competence in the professional association; Strahlenschutz fuer Mensch und Umwelt. 50 Jahre Kompetenz im Fachverband

    Energy Technology Data Exchange (ETDEWEB)

    Bucher, Benno [Eidgenoessisches Nuklearsicherheitsinspektorat, Brugg (Switzerland); Wilhelm, Christoph (ed.) [Karlsruher Institut fuer Technology (KIT), Eggenstein-Leopoldshafen (Germany)

    2016-07-01

    The conference proceedings of the IRPA (International radiation protection association) annual meeting 2016 contain the contribution of invited referents, other contributions and poster contributions concerning radiation protection in nuclear facilities, radiation protection of the public and environment, radioactive waste management, uranium mining, environmental monitoring, natural radioactivity, and radiation protection laws and regulations.

  15. ETAI 2003: 6. national conference with international participation. Proceedings; ETAI 2003: 6. nacionalna konferencija so megjunarodno uchestvo. Zbornik na trudovi

    Energy Technology Data Exchange (ETDEWEB)

    Stankovski, Mile J [ed.

    2003-07-01

    ETAI 2005 is the seventh of the series of theme conferences organized by the Society for ETAI of the Republic of Macedonia. The previous ones include ETAI '82, '85, '89, '93, 2000 and 2003. Traditionally, the Conference is held in the ambient of the reach rarity of the nature and the culture of Ohrid Coastal Area, protected by UNESCO. The scope of the Conference, following its cross-disciplinary character, is aimed towards studying and exposing both the theoretical and applied aspects in the field of Electronics, Telecommunications, Automatics and Informatics. The aim of the Conference is directed towards encouraging and stimulating the professional exchange of information and knowledge among people from academic institutions and from business and industry enterprises in the fields covered by ETAI. At the same time the Conference will enable a close and direct get-togetherness framework important for sharing people ideas and professional knowledge for the benefit of the common progress. The program of the ETAI 2003 contains three plenary lectures and 20 regular sessions including 85 contributed papers.

  16. Protection against H5N1 by multiple immunizations with seasonal influenza vaccine in mice is correlated with H5 cross-reactive antibodies

    NARCIS (Netherlands)

    Roos, Anna; Roozendaal, Ramon; Theeuwsen, Jessica; Riahi, Sarra; Vaneman, Joost; Tolboom, Jeroen; Dekking, Liesbeth; Koudstaal, Wouter; Goudsmit, Jaap; Radošević, Katarina

    2015-01-01

    Background: Current seasonal influenza vaccines are believed to confer protection against a narrow range of virus strains. However, their protective ability is commonly estimated based on an in vitro correlate of protection that only considers a subset of anti-influenza antibodies that are typically

  17. Proceedings of the First International Conference on Environmental Recovery of Yugoslavia

    International Nuclear Information System (INIS)

    Antic, D.; Vujic, J.

    2002-05-01

    The purpose of this book (monograph) is to describe various environmental consequences of NATO bombing in Federal Republic of Yugoslavia (FRY) from March 24 to June 10, 1999, and to give some recommendations for the environmental recovery of Yugoslavia. During the NATO bombing campaign in 1999, 78 industrial facilities and 45 energy installations were damaged or destroyed, releasing thousands of tons of various carcinogenic, mutagenic and toxic chemicals, including some persistent organic pollutants banned by the Stockholm convention for human use. Over 150,000 tons of oil and oil derivates and 367,000 tons of kerosene were burned, more than 20,000 residential buildings were destroyed, and at least 31,000 rounds of thirty millimeter DU munitions were fired. G17 group has estimated the damage to the infrastructure at over US$30 billion. The monograph is based on the papers presented at the First International Conference on Environmental Recovery of Yugoslavia, Belgrade, September 27 to 30, 2001 (ENRY2001). The conference included 142 presentations by 320 authors from 21 countries as well as three teleconference presentations from the U.S. Environmental Protection Agency(EPA). About 80 papers are included in the presented form, and some papers(about 30) are included in a modified (extended or completed) form. In order to have a more complete coverage in the book of important relevant topics,several contributions not presented at ENRY2001 are also included. An assessment of environmental damage and prospects for environmental remediation are presented. The status of the region up to 1991 (including preexisting ecological characteristics, as well as social and economical development), and the changes between 1991 and 2001 that include the effects of external economic sanctions, civil wars, and the NATO bombing in 1999 are included in the assessments. The ENRY2001 Activity Report and the Conference Conclusions and Recommendations are also included. These reports give a

  18. Conference record of the 1986 IEEE international conference on plasma science

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    This book presents the papers given at a conference on plasma science. Topics considered at the conference included inverse diode computations, collisional ion heating, gyrotron phase locking using a modulated electron beam, klystrons and lasertrons, radiation pressure on moving plasma, RF heating by cylindrical plasma waveguide modes, and deionization phase characteristics of hydrogen thyratron plasmas

  19. The Philippine Parliamentarians Conference on Human Survival, Population and Development. Summary.

    Science.gov (United States)

    1988-12-01

    Proceedings of the 1st Philippine Parliamentarians' Conference on Human Survival, Population and Development (PARLCON '88) are summarized in this report. Conference participants included the House and Senate, government officials, representatives of nongovernmental organizations, international organizations, the diplomatic corps and the media. A message from the President was read, referring the "silent emergency" of malnutrition and infant mortality of over 100,000 yearly. The events taking place were a statement of objectives, a Senate Resolution welcoming the convening of the conference, an opening ceremony, a posthumous award to R. M. Sales, executive director of the UNFPA, and a final a plan of action. Much of the content of the above events was duplicated in the final plan, which was formulated in 17 points. Some of these key points were: recognition of the need for quality of life, the detrimental effect of rapid population growth on development, the right of spouses to plan family size within their ethical beliefs, and the need for political will to address development concerns. The conference recommended that parliament and local governments strive for a consensus on national policy regarding population; ensure that economic gains are not decimated by population growth, protect the environment, develop social and industrial infrastructure in outlying areas, pursue national self-reliance, promote the human right of choosing desired family size, endorse the small family norm, empower women by educational and income generating opportunities, gather national data on population, strengthen the Population Commission, support nongovernmental agencies that provide family planning services, and promote education on family planning.

  20. Proceedings of the American Power Conference. Volume 58-II

    International Nuclear Information System (INIS)

    McBride, A.E.

    1996-01-01

    This book is part 2 of the proceedings of the American Power Conference, Technology for Competition and Globalization, 1996. The topics of the papers include structural plant design; challenges of the global marketplace; thermal hydraulic methods for nuclear power plant safety and operation; decontamination and decommissioning; competitive operations and maintenance; fuel opportunities; cooling; competitive power pricing; operations; transformers; relays; plant controls; training to meet the competitive future; burning technologies; ash and byproducts utilization; advanced systems; computer tools for plant design; globalization of power; power system protection and power quality; life extension; grounding; and transmission line equipment

  1. Proceedings of the American Power Conference. Volume 60-2

    International Nuclear Information System (INIS)

    McBride, A.E.

    1998-01-01

    The American Power Conference, 60th annual meeting, 1998, addressed reliability and economy as related to technology for competition and globalization. The topics of the papers included needs and advances in power engineering education, global climate change, distributed generation, the critical role of the nations largest coal, nuclear and hydropower stations, advances in generation technology, financing electric power projects, successful deregulation, year 2000 outlook for equipment conflict with information and control, system planning, asset management, relay and communication, particulate and SO x control, environmental protection compliance strategies, fuel cells, gas turbines, renewable energy, steam turbines, and cost reduction strategies

  2. NASA Microgravity Materials Science Conference

    Science.gov (United States)

    Gillies, D. C. (Compiler); McCauley, D. E. (Compiler)

    1999-01-01

    The Microgravity Materials Science Conference was held July 14-16, 1998 at the Von Braun Center in Huntsville, AL. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division at NASA Headquarters, and hosted by the NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications. It was the third NASA conference of this type in the microgravity materials science discipline. The microgravity science program sponsored approximately 125 investigations and 100 principal investigators in FY98, almost all of whom made oral or poster presentations at this conference. The conference's purpose was to inform the materials science community of research opportunities in reduced gravity in preparation for a NASA Research Announcement scheduled for release in late 1998 by the Microgravity Research Division at NASA Headquarters. The conference was aimed at materials science researchers from academia, industry, and government. A tour of the Marshall Space Flight Center microgravity research facilities was held on July 16, 1998. This volume is comprised of the research reports submitted by the principal investigators after the conference.

  3. 6th international conference on Mars polar science and exploration: Conference summary and five top questions

    Science.gov (United States)

    Smith, Isaac B.; Diniega, Serina; Beaty, David W.; Thorsteinsson, Thorsteinn; Becerra, Patricio; Bramson, Ali; Clifford, Stephen M.; Hvidberg, Christine S.; Portyankina, Ganna; Piqueux, Sylvain; Spiga, Aymeric; Titus, Timothy N.

    2018-01-01

    We provide a historical context of the International Conference on Mars Polar Science and Exploration and summarize the proceedings from the 6th iteration of this meeting. In particular, we identify five key Mars polar science questions based primarily on presentations and discussions at the conference and discuss the overlap between some of those questions. We briefly describe the seven scientific field trips that were offered at the conference, which greatly supplemented conference discussion of Mars polar processes and landforms. We end with suggestions for measurements, modeling, and laboratory and field work that were highlighted during conference discussion as necessary steps to address key knowledge gaps.

  4. An Overview: Consumer Protection in Higher Education. Why? For Whom? How?

    Science.gov (United States)

    Willett, Sandra L.

    The protection of the student and prospective student at the postsecondary level is examined. Twenty-five possible educational abuses and concerns, such as discriminatory refund policies and misrepresentation, identified by the Federal Interagency on Education are listed. Ten issues selected as the thrust of the first National Conference on…

  5. 4th Neutron Transmutation Doping Conference

    CERN Document Server

    1984-01-01

    viii The growing use of NTD silicon outside the U. S. A. motivated an interest in having the next NTD conference in Europe. Therefore, the Third International Conference on Neutron Transmutation-Doped Silicon was organized by Jens Guldberg and held in Copenhagen, Denmark on August 27-29, 1980. The papers presented at this conference reviewed the developments which occurred during the t'A'O years since the previous conference and included papers on irradiation technology, radiation-induced defects, characteriza­ tion of NTD silicon, and the use of NTD silicon for device appli­ cations. The proceedings of this conference were edited by Jens Guldberg and published by Plenum Press in 1981. Interest in, and commercial use of, NTD silicon continued to grow after the Third NTD Conference, and research into neutron trans­ mutation doping of nonsilicon semiconductors had begun to accel­ erate. The Fourth International Transmutation Doping Conference reported in this volume includes invited papers summarizing the p...

  6. Proceedings of OttawaGeo 2007 : the Diamond Jubilee 60. Canadian Geotechnical Conference and 8. Joint CGS/IAH-CNC Groundwater Conference : Breaking Ground in the Nation's Capital

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This conference provided a forum for more than 600 delegates from industry, government universities and research centres to share their professional knowledge on research and development that affects all sectors of geotechnical engineering, applied geology and hydrogeology. Accomplishments in the geoenvironmental field were also highlighted. The geotechnical themes included buried structures; cold region engineering; computer modelling; earthquake engineering; engineering geology; foundation engineering; landfills and contaminated sites; mining geotechniques and the environment; slope stability/landslides; unsaturated soils; geosynthetics; problematic soils; rock mechanics; soil dynamics and liquefaction; and, soil-structure interactions. The hydrogeology themes included applications of geophysics to hydrogeology; aquifer case studies; hydrogeology of the Canadian Shield; hydrogeology of the Great Lakes Basin and St. Lawrence Lowlands; quantitative performance assessment of contaminant remediation; radioactive waste management; and, source water protection. The conference featured more than 320 presentations, of which 35 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  7. The objectives and activities of the Canadian Radiation Protection Association

    International Nuclear Information System (INIS)

    Haynes, M.J.

    1998-01-01

    The Canadian Nuclear Society and the Canadian Radiation Protection Association are working to develop an agreement between the organizations to facilitate working together on issues of common interest. This paper will present the objectives, the organizational structure and major areas of activity of the Canadian Radiation Protection Association. It is a reciprocal presentation of one given earlier this year by Mr. Fred Boyd of the CNS to the CRPA annual conference. The intent is to help the membership of each organization better understand the objectives and interests of the other. (author)

  8. Herd protection effect of N95 respirators in healthcare workers.

    Science.gov (United States)

    Chen, Xin; Chughtai, Abrar Ahmad; MacIntyre, Chandini Raina

    2017-12-01

    Objective To determine if there was herd protection conferred to unprotected healthcare workers (HCWs) by N95 respirators worn by colleagues. Methods Data were analysed from a prospective cluster randomized clinical trial conducted in Beijing, China between 1 December 2008 and 15 January 2009. A minimum compliance level (MCL) of N95 respirators for prevention of clinical respiratory illness (CRI) was set based on various compliance cut-offs. The CRI rates were compared between compliant (≥MCL) and non-compliant (protection from use of N95 respirators by colleagues within a hospital ward.

  9. Conference report: formulating better medicines for children: 4th European Paediatric Formulation Initiative conference.

    Science.gov (United States)

    Walsh, Jennifer; Mills, Simon

    2013-01-01

    The fourth annual European Paediatric Formulation Initiative (EuPFI) conference on Formulating Better Medicines for Children was held on 19-20 September 2012 at the Institute of Molecular Genetics Congress Centre, Prague, Czech Republic. The 2-day conference concentrated on the latest advances, challenges and opportunities for developing medicinal products and administration devices for pediatric use, both from European and US perspectives. It was aimed specifically at providing exposure to emerging practical applications, and for illustrating remedies utilized by pediatric drug-development teams to overcome hurdles faced in developing medicines for pediatric patients. The conference format included plenary talks, focus sessions on each of the EuPFI work streams (extemporaneous preparations, excipients, pediatric administration devices, taste masking and taste assessment, age-appropriate formulations), case studies, soapbox sessions and a parallel poster display. This conference report summarizes the keynote lectures and also gives a flavor of other presentations and posters from the conference.

  10. Radiation Protection Training in Spanish schools of medicine

    International Nuclear Information System (INIS)

    Ruiz-Cruces, R.; Perez Martinez, M.; Vano, E.; Hernandez Armas, J.; Diez de los Rios Delgado, A.

    2003-01-01

    Radiation Protection should be included in the programme of studies necessary to confer a bachelor's degree in Medicine, according to the Directive 97/43 Euratom on medical exposures and the Report RP116 published by the European commission on Education and Training in radiation protection for medical exposures. To analyse the present training programmes in radiation protection at the Medical School in different Spanish Universities. The syllabus and the contents of the subjects including radiation protection issues in 27 Spanish Schools of Medicine have been revised. Radiation protection subjects are obligatory at present, only at the Schools of Medicine from Cantabria and Malaga. There is a group of Schools of Medicine where radiation protection is an optional matter with an extension of 4,5 credits (45 hours). It also exists some topics in radiation protection in subjects dealing with Medical Physics and General Radiology (with a range value from 1 to 10 hours), in 10 Schools of Medicine. A wide dispersion among the contents of different subjects and the hours of training allocated by the different School are found. It should be useful the harmonization of the programmes. (Author)

  11. 76 FR 57746 - Conference on the International Conference on Harmonisation Q10 Pharmaceutical Quality System: A...

    Science.gov (United States)

    2011-09-16

    ...] Conference on the International Conference on Harmonisation Q10 Pharmaceutical Quality System: A Practical Approach to Effective Life- Cycle Implementation of Systems and Processes for Pharmaceutical Manufacturing... ``Pharmaceutical Quality System (ICH Q10) Conference: A Practical Approach to Effective Life- Cycle Implementation...

  12. The Paris Climate Conference: What kind of international agreement in 2015?

    International Nuclear Information System (INIS)

    Lemmet, Sylvie; Watkinson, Paul; Navizet, Damien

    2015-01-01

    At stake during the 21. Climate Conference (COP21) to be held in Paris in 2015 is the adoption of a worldwide agreement that can be applied to all countries. This agreement, which will take effect by 2020, will focus not only on reducing greenhouse gases and adapting to climate change but also on funding and concrete actions for sustainable, resilient economic development. Throughout the coming year, France, which hosts and chairs the COP21, must see to it that a transparent, inclusive process allows all parties to express their viewpoints and be heard. An agreement is not the only result expected of this conference. For the sake of fairness and in order to limit global warming to 2 deg. C, pledges and commitments, including financial ones, from countries in favor of protecting the climate are expected too. International recognition will also have to be provided to climate-related initiatives that have already been launched

  13. Energy policies and climate protection

    International Nuclear Information System (INIS)

    Kerr, A.

    1994-01-01

    One year after the United Nations Conference on Environment and Development, an assessment is made of what progress is being made towards sustainability. The work of the Intergovernmental Panel on Climate Change (IPCC) on climate change has provided the expert background for action to protect the climate. It lists some of the measured and noticed first signs of climate change as identified by the German Bundestag Enquete Commission, and mentions the effects of climatically induced catastrophes on the world's insurance industry and the fact that the Third World is likely to suffer most from climatic change. A Greenpeace report advocates the phasing out of fossil fuels and of nuclear power as a way to combat climatic change. The article reviews developments relevant to protecting the climate worldwide and specifically in the Netherlands, incorporating Greenpeace's views on these

  14. Corrosion/94 conference papers

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    The approximately 500 papers from this conference are divided into the following sections: Rail transit systems--stray current corrosion problems and control; Total quality in the coatings industry; Deterioration mechanisms of alloys at high temperatures--prevention and remediation; Research needs and new developments in oxygen scavengers; Computers in corrosion control--knowledge based system; Corrosion and corrosivity sensors; Corrosion and corrosion control of steel reinforced concrete structures; Microbiologically influenced corrosion; Practical applications in mitigating CO 2 corrosion; Mineral scale deposit control in oilfield-related operations; Corrosion of materials in nuclear systems; Testing nonmetallics for life prediction; Refinery industry corrosion; Underground corrosion control; Mechanisms and applications of deposit and scale control additives; Corrosion in power transmission and distribution systems; Corrosion inhibitor testing and field application in oil and gas systems; Decontamination technology; Ozone in cooling water applications, testing, and mechanisms; Corrosion of water and sewage treatment, collection, and distribution systems; Environmental cracking of materials; Metallurgy of oil and gas field equipment; Corrosion measurement technology; Duplex stainless steels in the chemical process industries; Corrosion in the pulp and paper industry; Advances in cooling water treatment; Marine corrosion; Performance of materials in environments applicable to fossil energy systems; Environmental degradation of and methods of protection for military and aerospace materials; Rail equipment corrosion; Cathodic protection in natural waters; Characterization of air pollution control system environments; and Deposit-related problems in industrial boilers. Papers have been processed separately for inclusion on the data base

  15. Berkeley Conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1986-10-15

    To a regular observer at annual international meetings, progress in particle physics from one year to the next sometimes might seem ponderously slow. But shift the timescale and the result is startling. Opening his summary of the 1986 International Conference on High Energy Physics, held in Berkeley, California, from 16-23 July, Steve Weinberg first recalled the 1966 Conference, also held in Berkeley. Then the preoccupations were current algebra, hadron resonances and the interpretation of scattering in terms of Regge poles, and the theory of weak interactions. Physics certainly has moved.

  16. Berkeley Conference

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    To a regular observer at annual international meetings, progress in particle physics from one year to the next sometimes might seem ponderously slow. But shift the timescale and the result is startling. Opening his summary of the 1986 International Conference on High Energy Physics, held in Berkeley, California, from 16-23 July, Steve Weinberg first recalled the 1966 Conference, also held in Berkeley. Then the preoccupations were current algebra, hadron resonances and the interpretation of scattering in terms of Regge poles, and the theory of weak interactions. Physics certainly has moved

  17. Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death

    DEFF Research Database (Denmark)

    Juel, Helene B; Faber, Carsten; Svendsen, Signe Goul

    2013-01-01

    -mediated induction of the anti-oxidative stress response, upregulating protective anti-oxidant pathway(s). These findings suggest caution for the clinical use of anti-inflammatory agents in the management of immune-associated eye diseases such as age-related macular degeneration....... protected from cell death by the addition of PCM. This protection was conferred, at least in part, by IFNγ and TNFα. Cell death induced by H2O2 or NaIO3 was preceded by mitochondrial dysfunction and by p62 upregulation, both of which were attenuated by PCM and/or by IFNγ+TNFα. RPE cells co...

  18. Partial protection of SIV-infected rhesus monkeys against superinfection with a heterologous SIV isolate

    Energy Technology Data Exchange (ETDEWEB)

    Korber, Bette [Los Alamos National Laboratory

    2009-01-01

    Although there is increasing evidence that individuals already infected with human immunodeficiency virus type 1 (HIV-1) can be infected with a heterologous strain of the virus, the extent of protection against superinfection conferred by the first infection and the biologic consequences of superinfection are not well understood. We explored these questions in the simian immunodeficiency virus (SIV)/rhesus monkey model of HIV-1/AIDS. We infected cohorts of rhesus monkeys with either SIVmac251 or SIVsmE660 and then exposed animals to the reciprocal virus through intrarectal inoculations. Employing a quantitative real-time PCR assay, we determined the replication kinetics of the two strains of virus for 20 weeks. We found that primary infection with a replication-competent virus did not protect against acquisition of infection by a heterologous virus but did confer relative control of the superinfecting virus. In animals that became superinfected, there was a reduction in peak replication and rapid control of the second virus. The relative susceptibility to superinfection was not correlated with CD4(+) T-cell count, CD4(+) memory T-cell subsets, cytokine production by virus-specific CD8(+) or CD4(+) cells, or neutralizing antibodies at the time of exposure to the second virus. Although there were transient increases in viral loads of the primary virus and a modest decline in CD4(+) T-cell counts after superinfection, there was no evidence of disease acceleration. These findings indicate that an immunodeficiency virus infection confers partial protection against a second immunodeficiency virus infection, but this protection may be mediated by mechanisms other than classical adaptive immune responses.

  19. XXII Fluid Mechanics Conference (KKMP2016)

    International Nuclear Information System (INIS)

    2016-01-01

    This Journal of Physics: Conference Series contains papers that have been presented at XXII Fluid Mechanics Conference (XXII FMC) held in Słok near Bełchatów in Poland during llth-14th September of 2016. The Conference is organized by Wrocław University of Science and Technology, Polish Academy of Sciences - Committee of Mechanics and Foun-dation for Development of Wroclaw University of Science and Technology. Let us recall some historical facts: Fluid Mechanics Conferences have been taking place every two years since 1974, which makes a total of forty-two years. The goal of this conference is to provide a forum for exposure and exchange of ideas, methods and results in fluid mechanics. We have already met in Bełchatów 10 years ago (XVII KKMP). It was a successful meeting. Since then the National Conference on Fluid Mechanics has changed title and has started to be named Fluid Mechanics Conference in the hopes that it will attract more participants from other countries. English became the Conference's first language and we started to invite world leading scientists - working in the field of fluid mechanics. At the 2006 conference we hosted for the first time prof. Keith Moffatt from the Cambridge University. In this year prof. Moffatt once again promised us to arrive to Bełchatów. The whole fluid mechanics community celebrates 9 2 anniversary of his birthday. So let us also wish happy anniversary to prof. Moffatt. In the mean time we had to pay last respects to our collages. Prof. Prosnak who is regarded as a founder of the Notational Conference on Fluid Mechanics and is well known through his books. Prof. Puzyrewski who was present at all conferences so far. He was providing via his discussions a special value to these conferences, and our colleague prof. Konrad Bajer who was intended to be the organizer and host of the present conference. Short memories to them will be given during the opening ceremony. Conference topics include, but are not limited

  20. International conference Caspy-95. Caspian region: economy, ecology, mineral resources. Technical abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Anon,

    1996-12-31

    The collection of technical abstracts submitted to the International conference Caspy-95 held in Moscow (the Russian Federation), June 20-23, 1995, contains 166 presentations in the following fields: (1) Sea levels`s fluctuation and changes of water balance; (2) Geodynamics of the Caspian region; (3) Prospecting, exploration and exploitation of oil and gas fields; (4) Ecological and environmental problems; (5) Complex monitoring and engineering coastal protection; (6) Social-economical and legal aspects of natural resources usage.

  1. International conference Caspy-95. Caspian region: economy, ecology, mineral resources. Technical abstracts

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    The collection of technical abstracts submitted to the International conference Caspy-95 held in Moscow (the Russian Federation), June 20-23, 1995, contains 166 presentations in the following fields: 1) Sea levels's fluctuation and changes of water balance; 2) Geodynamics of the Caspian region; 3) Prospecting, exploration and exploitation of oil and gas fields; 4) Ecological and environmental problems; 5) Complex monitoring and engineering coastal protection; 6) Social-economical and legal aspects of natural resources usage

  2. Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.

    Science.gov (United States)

    Clarke, E; Desselberger, U

    2015-01-01

    Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respectively. Infection results in a variable level of protection from subsequent reinfection and disease. This protection is predominantly homotypic in some settings, whereas broader heterotypic protection is reported in other cohorts. Two antigenically distinct oral RV vaccines are licensed and are being rolled out widely, including in resource-poor setting, with funding provided by the GAVI alliance. First is a monovalent vaccine derived from a live-attenuated human RV strain, whereas the second is a pentavalent bovine-human reassortment vaccine. Both vaccines are highly efficacious in high-income settings, but greatly reduced levels of protection are reported in low-income countries. Here, the current challenges facing mucosal immunologists and vaccinologists aiming to define immunological correlates and to understand the variable levels of protection conferred by these vaccines in humans is considered. Such understanding is critical to maximize the public health impact of the current vaccines and also to the development of the next generation of RV vaccines, which are needed.

  3. 75 FR 23222 - National Poultry Improvement Plan; General Conference Committee Meeting and 40th Biennial Conference

    Science.gov (United States)

    2010-05-03

    ...] National Poultry Improvement Plan; General Conference Committee Meeting and 40th Biennial Conference AGENCY... notice of a meeting of the General Conference Committee of the National Poultry Improvement Plan (NPIP... Coordinator, National Poultry Improvement Plan, VS, APHIS, 1498 Klondike Road, Suite 101, Conyers, GA 30094...

  4. 77 FR 46374 - National Poultry Improvement Plan; General Conference Committee Meeting and 41st Biennial Conference

    Science.gov (United States)

    2012-08-03

    ...] National Poultry Improvement Plan; General Conference Committee Meeting and 41st Biennial Conference AGENCY... notice of a meeting of the General Conference Committee of the National Poultry Improvement Plan (NPIP... CONTACT: Dr. C. Stephen Roney, Senior Coordinator, National Poultry Improvement Plan, VS, APHIS, 1506...

  5. Physical characteristics of the paper filter and low cafestol content filter coffee brews.

    Science.gov (United States)

    Rendón, Mery Yovana; Dos Santos Scholz, Maria Brígida; Bragagnolo, Neura

    2018-06-01

    The results found in the literature concerning the effect of consuming filter coffee brews on increasing the blood cholesterol levels due to the presence of diterpenes, are divergent. Thus the present research evaluated the diterpene (cafestol and kahweol) concentrations in filter coffee brews prepared with paper filters of different sizes, colors and origins (Brazil, Japan, The United States of America, Germany, France and the Netherlands), with and without micro perforations. This is the first study that reports the physical characteristics of paper filter and its importance to obtain filter coffee brew with low cafestol content. Thus, a sample of Catuai cultivar coffee with high cafestol content was roasted to a medium-light degree and used to prepare the brews in a 1:10 ratio (coffee powder to water). The diterpenes were extracted by direct saponification and quantified and identified by HPLC-DAD-MS/MS. The paper filters were physically characterized by measuring their grammage, and the fat permeation rate calculated in order to better understand the differences between the filters which allow one to obtain higher or lower diterpene contents. The cafestol and kahweol concentrations in the brews varied from 1.62 to 2.98 mg/L and from 0.73 to 1.96 mg/L, respectively. The highest cafestol and kahweol concentrations were obtained using paper filters with micro perforations, considering similar sized paper filters. The paper filters showed high fat permeability and grammages between 50.46 and 67.48 g/m 2 . The diterpene retention capacities of the filters produced in the different countries were similar. The results showed that the porosity of the paper filter and the particle size of the ground roasted coffee were determinant factors in obtaining filter coffee brews with lower cafestol contents. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Conference on Islamic Accounting and Finance

    OpenAIRE

    AYAYDIN, Hasan

    2016-01-01

    Abstract. Hasan Kalyoncu Univeristy organized first of its conference series as “Conference on Islamic Accounting and Finance” themed on October 27-28, 2016 in Gaziantep, Turkey. Conference on Islamic Accounting and Finance aims to establish an academic forum for scholars, researchers and practitioners to exchange their ideas about aspects of Islamic accounting, auditing, business ethics and financial reporting. Submitted papers as well as presentations and discussions at the conference were ...

  7. PREFACE: 13th International Conference on Electrostatics

    Science.gov (United States)

    Taylor, D. Martin

    2011-06-01

    Electrostatics 2011 was held in the city of Bangor which is located in North West Wales in an area of outstanding natural beauty close to the Snowdonia mountain range and bordering the Irish Sea. The history of the area goes back into the mists of times, but a continuous technological thread can be traced from the stone- and bronze-age craftsmen, who inhabited the area several thousand years ago, via the civil engineering and fortifications of the Romans and Edward I of England, through Marconi's long-wave trans-Atlantic transmitter near Caernarfon to the conference host. The School of Electronic Engineering at Bangor University has contributed much to the discipline of Electrostatics not only in teaching and research but also in supporting industry. It was a great pleasure for me, therefore, to have the pleasure of welcoming the world's experts in Electrostatics to Bangor in April 2011. In my preface to the Proceedings of Electrostatics 1999, I reported that almost 90 papers were presented. Interestingly, a similar number were presented in 2011 testifying to the importance and endurance of the subject. The all-embracing nature of electrostatics is captured in the pictorial depiction used for the conference logo: a hand-held plasma ball with its close link to gaseous discharges and the superimposed Antarctic aurora highlighting the featured conference themes of atmospheric, planetary and environmental electrostatics. Leading these themes were three invited contributions, the first by Giles Harrison who delivered the Bill Bright Memorial Lecture 'Fair weather atmospheric electricity', Carlos Calle on 'The electrostatic environments of Mars and the Moon' and Istvan Berta on 'Lightning protection - challenges, solutions and questionable steps in the 21st century'. Leading other key sessions were invited papers by Atsushi Ohsawa on 'Statistical analysis of fires and explosions attributed to static electricity over the last 50 years in Japanese industry' and Antonio

  8. A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection.

    Science.gov (United States)

    Pieler, Michael M; Frentzel, Sarah; Bruder, Dunja; Wolff, Michael W; Reichl, Udo

    2016-12-07

    Downstream processing and formulation of viral vaccines employs a large number of different unit operations to achieve the desired product qualities. The complexity of individual process steps involved, the need for time consuming studies towards the optimization of virus yields, and very high requirements regarding potency and safety of vaccines results typically in long lead times for the establishment of new processes. To overcome such obstacles, to enable fast screening of potential vaccine candidates, and to explore options for production of low cost veterinary vaccines a new platform for whole virus particle purification and formulation based on magnetic particles has been established. Proof of concept was carried out with influenza A virus particles produced in suspension Madin Darby canine kidney (MDCK) cells. The clarified, inactivated, concentrated, and diafiltered virus particles were bound to magnetic sulfated cellulose particles (MSCP), and directly injected into mice for immunization including positive and negative controls. We show here, that in contrast to the mock-immunized group, vaccination of mice with antigen-loaded MSCP (aMSCP) resulted in high anti-influenza A antibody responses and full protection against a lethal challenge with replication competent influenza A virus. Antiviral protection correlated with a 400-fold reduced number of influenza nucleoprotein gene copies in the lungs of aMSCP immunized mice compared to mock-treated animals, indicating the efficient induction of antiviral immunity by this novel approach. Thus, our data proved the use of MSCP for purification and formulation of the influenza vaccine to be fast and efficient, and to confer protection of mice against influenza A virus infection. Furthermore, the method proposed has the potential for fast purification of virus particles directly from bioreactor harvests with a minimum number of process steps towards formulation of low-cost veterinary vaccines, and for screening

  9. Mechanisms of symbiont-conferred protection against natural enemies: an ecological and evolutionary framework.

    Science.gov (United States)

    Gerardo, Nicole M; Parker, Benjamin J

    2014-10-01

    Many vertically-transmitted microbial symbionts protect their insect hosts from natural enemies, including host-targeted pathogens and parasites, and those vectored by insects to other hosts. Protection is often achieved through production of inhibiting toxins, which is not surprising given that toxin production mediates competition in many environments. Classical models of macroecological interactions, however, demonstrate that interspecific competition can be less direct, and recent research indicates that symbiont-protection can be mediated through exploitation of limiting resources, and through activation of host immune mechanisms that then suppress natural enemies. Available data, though limited, suggest that effects of symbionts on vectored pathogens and parasites, as compared to those that are host-targeted, are more likely to result from symbiont activation of the host immune system. We discuss these different mechanisms in light of their potential impact on the evolution of host physiological processes. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. 2007 Joint Chemical Biological, Radiological and Nuclear (CBRN) Conference and Exhibition - Combating Weapons of Mass Destruction

    Science.gov (United States)

    2007-06-27

    Selected CB Defense Systems SHAPESENSE Joint Warning and Reporting Network JSLIST CB Protected Shelter Joint Vaccine Acquisition Program Joint Effects...military can operate in any environment, unconstrained by chemical or biological weapons. 21 SHIELD SUSTAIN Selected CB Defense Systems SHAPESENSE Joint...28070625_JCBRN_Conference_Reeves UNCLASSIFIED Decontamination Vision Strippable Barriers Self-Decontaminating Fabrics/Coatings Reduce Logistics Burden

  11. Proceedings of the Conference and Symposium Korean Association for Radiation Protection Fall Meeting 2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    This proceedings contains articles of the Korean Association for Radiation Protection Fall Meeting, 2011. It was held on Nov.17-18, 2011 the ocean resort in Yeosu, Korea and subject of the Korean Association for Radiation Protection Fall Meeting 2011. This proceedings is comprised of 14 sessions.

  12. Sakharov readings 2015: environmental problems of the XXI century. Proceedings of the 15 international scientific conference

    International Nuclear Information System (INIS)

    Poznyak, S.S.; Lysukho, N.A.

    2015-05-01

    The proceeding includes materials of reports of 15-th international scientific conference 'Sakharov readings 2015: Environmental problems of XXI century', which took place 21-22 of May 2015 in the International A. Sakharov Environmental University (Minsk, Belarus). The proceeding continues abstracts about philosophical, social-ecological nd bioethical and problems of modernity; education for sustainable development; medical ecology; biological ecology; radiobiology; radioecology and radiation protection; information systems and technologies in ecology and medicine; regional environmental problems; ecological monitoring and management; renewable energy sources and energy efficiency. Materials of the conference intend on wide area of the specialists in ecology and adjacent sciences, teachers, post-graduate students and students of universities and colleges. (authors)

  13. 17th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2012-01-01

    Cryocoolers 17 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 17th International Cryocooler Conference that was held in Los Angeles, California, on July 9-12, 2012. The program of this conference consisted of 94 papers; of these, 71 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  14. 16th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2011-01-01

    Cryocoolers 16 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 16th International Cryocooler Conference that was held in Atlanta, Georgia, on May 17-20, 2010. The program of this conference consisted of 116 papers; of these, 89 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  15. Aviation Safety/Automation Program Conference

    Science.gov (United States)

    Morello, Samuel A. (Compiler)

    1990-01-01

    The Aviation Safety/Automation Program Conference - 1989 was sponsored by the NASA Langley Research Center on 11 to 12 October 1989. The conference, held at the Sheraton Beach Inn and Conference Center, Virginia Beach, Virginia, was chaired by Samuel A. Morello. The primary objective of the conference was to ensure effective communication and technology transfer by providing a forum for technical interchange of current operational problems and program results to date. The Aviation Safety/Automation Program has as its primary goal to improve the safety of the national airspace system through the development and integration of human-centered automation technologies for aircraft crews and air traffic controllers.

  16. S.F.R.P.99 national congress of radiation protection

    International Nuclear Information System (INIS)

    1999-01-01

    This conference treats the problem of radiation protection, in nuclear industry, nuclear medicine. The new regulations lead to an improvement in that area. The question of low doses is discussed. The natural radioactivity is evoked with the radon and the perception of the nuclear risk by the public is the object of several reports. (N.C.)

  17. Washington Conference

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    The 1981 Particle Accelerator Conference was held in Washington from 11-13 March. It was the ninth in the series of meetings organized in the USA which differ from the 'International' meetings in their coverage of the full range of accelerator engineering and technology, including applications outside e field of high energy physics. The Conference took place under the cloud of further budget cuts for Fiscal Year 1982 in the USA which the Department of Energy has applied in line with the financial policy of the new administration. Coming on top of many years of budget trimming which have reduced the number of high energy physics Laboratories funded by the DOE to three (Brookhaven, Fermilab, Stanford - Cornell is funded by the National Science Foundation) and reduced the exploitation of these Laboratories to less than half of their potential, the new cuts did not exactly help to boost morale. Nevertheless, the huge amount of tailed work in accelerator physics and technology which was presented at the Conference showed how alive the field is

  18. International conference on string theory

    CERN Document Server

    2017-01-01

    The Strings 2017 conference is part of the "Strings" series of annual conferences, that bring the entire string theory community together. It will include reviews of major developments in the field, and specialized talks on specific topics. There will also be several public lectures given by conference participants, a pre-Strings school at the Technion, and a post-Strings workshop at the Weizmann Institute.

  19. 15th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2009-01-01

    This is the 15th volume in the conference series. Over the years the International Cryocooler Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  20. 14th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2007-01-01

    This is the 14th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  1. EVOLVE 2014 International Conference

    CERN Document Server

    Tantar, Emilia; Sun, Jian-Qiao; Zhang, Wei; Ding, Qian; Schütze, Oliver; Emmerich, Michael; Legrand, Pierrick; Moral, Pierre; Coello, Carlos

    2014-01-01

    This volume encloses research articles that were presented at the EVOLVE 2014 International Conference in Beijing, China, July 1–4, 2014.The book gathers contributions that emerged from the conference tracks, ranging from probability to set oriented numerics and evolutionary computation; all complemented by the bridging purpose of the conference, e.g. Complex Networks and Landscape Analysis, or by the more application oriented perspective. The novelty of the volume, when considering the EVOLVE series, comes from targeting also the practitioner’s view. This is supported by the Machine Learning Applied to Networks and Practical Aspects of Evolutionary Algorithms tracks, providing surveys on new application areas, as in the networking area and useful insights in the development of evolutionary techniques, from a practitioner’s perspective. Complementary to these directions, the conference tracks supporting the volume, follow on the individual advancements of the subareas constituting the scope of the confe...

  2. 2nd International Arctic Ungulate Conference

    OpenAIRE

    Anonymous, A.

    1996-01-01

    The 2nd International Arctic Ungulate Conference was held 13-17 August 1995 on the University of Alaska Fairbanks campus. The Institute of Arctic Biology and the Alaska Cooperative Fish and Wildlife Research Unit were responsible for organizing the conference with assistance from biologists with state and federal agencies and commercial organizations. David R. Klein was chair of the conference organizing committee. Over 200 people attended the conference, coming from 10 different countries. T...

  3. THz waves: biological effects, industrial and medical applications. Meeting of the non-ionizing radiation section of the French radiation protection society (SFRP). Conference review

    International Nuclear Information System (INIS)

    Souques, M.; Magne, I.

    2011-01-01

    Following the debates about body scanners installed in airports for passengers security control, the non-ionizing radiations (NIR) section of the French radiation protection society (SFRP) has organized a conference day to take stock of the present day knowledge about the physical aspects and the biological effects of this frequency range as well as about their medical, and industrial applications (both civil and military). This document summarizes the content of the different presentations: THz spectro-imaging technique: status and perspectives (P. Mounaix); THz technology: seeing the invisible? (J.P. Caumes); interaction of millimeter waves with living material: from dosimetry to biological impacts (Y. Le Drean and M. Zhadobov); Tera-Hertz: biological and medical applications (G. Gallot); Tera-Hertz: standards and recommendations (B. Veyret); Biological applications of THz radiation: a review of events and a glance to the future (G.P. Gallerano); Industrial and military applications - liquids and solids detection in the THz domain (F. Garet); THz radiation and its civil and military applications - gas detection and quantifying (G. Mouret); Body scanners and civil aviation security (J.C. Guilpin). (J.S.)

  4. International Conference on Climate Change Adaptation Assessments: Conference summary and statement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    The International Conference on Climate Change Adaptation Assessments was held in St. Petersburg, Russian Federation, from May 22--25, 1995. Sponsored by the Russian Federal Service for Hydrometeorology and Environmental Monitoring, the US Country Studies Program, and the directorate General for International Cooperation of the Netherlands Government, it was the first international conference focusing exclusively on adaptation to climate change. More than 100 people from 29 countries on five continents participated. The conference primarily addressed measures to anticipate the potential effects of climate change to minimize negative effects and take advantage of any positive effects. The focus was on what governments, institutions, and individuals can do to prepare for climate change. The conference dealt with two major topics: What adaptation options are most effective and efficient in anticipating climate change and what methods should be used to assess the effectiveness and efficiency of adaptation options. Brief summaries are given from the following sessions on agriculture; Water resources; coastal resources; ecosystems and forests; fisheries; human settlements; water and agriculture; and the panel session on international adaptation in national communications and other development plans and needs for technical assistance.

  5. PREFACE: The Irago Conference 2012

    Science.gov (United States)

    Sandhu, Adarsh; Okada, Hiroshi

    2013-04-01

    The Irago Conference 2012 - 360 degree outlook on critical scientific and technological challenges for a sustainable society Organized by the Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) at Toyohashi University of Technology, the Irago Conference, held recently (15-16 November) in Aichi, Japan, aimed to enhance mutual understanding between scientists, engineers and policymakers. Over 180 participants tackled topics ranging from energy and natural resources to public health and disaster prevention. The 360-degree outlook of the conference impressed speakers and guests. ''This conference has been extremely informative,'' noted Robert Gellar from the University of Tokyo. ''A unique conference with experts from a range of backgrounds,'' agreed Uracha Ruktanonchai from the National Nanotechnology Center (NANOTEC) in Thailand. Similarly, G P Li, professor of electrical engineering and computer science at the University of California Irvine commented that he had been ''able to think the unthinkable'' as a range of topics came together. The conference was streamed live on Ustream to ensure that researchers from across the world could benefit from thought-provoking presentations examining global issues such as energy, disaster mitigation and nanotechnology. ''This was wonderful,'' said Oussama Khatib from Stanford University, ''A good recipe of speakers from such a range of backgrounds.'' Manuscripts submitted to the organizers were peer-reviewed, and the papers in this proceedings were accepted for Journal of Physics: Conference Series. In addition to the formal speaker programme, graduate-student sessions provided a platform for graduate students to describe their latest findings as oral presentations. A series of excursions to relevant locations, such as the Tahara megasolar region under construction and a local car-manufacturing factory, gave participants the opportunity to further consider practical applications of their research in industry

  6. Sakharov readings 2012: environmental problems of the XXI century. Proceedings of 12 international scientific conference

    International Nuclear Information System (INIS)

    Kundas, S.P.; Poznyak, S.S.

    2012-05-01

    The proceeding includes materials of reports of 12-th international scientific conference 'Sakharov readings 2012: Environmental problems of XXI century', which took place 17-18 of May 2012 in the International A. Sakharov Environmental University (Minsk, Belarus). The proceeding continues abstracts about social-ecological, ecology-ethical and pedagogical problems in light of the Sakharov' ideas; medical ecology; biological ecology; biomonitoring, bioindication and bioremediation; radioecology and radiation protection; information systems and technologies in ecology and medicine; ecological monitoring, management and audit; renewable energy sources and energy efficiency; climate change and sustainable development; regional ecological problems. Materials of the conference intend on wide area of the specialists in ecology and adjacent sciences, teachers, post-graduate students and students of universities and colleges.

  7. Low Energy Conference 2009

    Energy Technology Data Exchange (ETDEWEB)

    2009-07-01

    11 of the 19 presentations have been indexed for the database. The following national organisations jointly organised the Low-energy Conference 2009: The Norwegian Society for the Conservation of Nature, the Norwegian Society of Engineers and Technologists, Norwegian Technology, the Federation of Norwegian Industries and the Low-Energy Program. Energy efficiency is often given little attention in the ongoing debates concerning different initiatives in order to reduce greenhouse emissions. The aim of the conference was to set energy efficiency on the agenda as an important environmental instrument. Both the Intergovernmental Panel on Climate Change - IPCC and the International Energy Agency - IEA regard energy efficiency as one of the fastest and most effective ways of reducing greenhouse emissions. Despite of this little is done. Many countries are ahead of Norway - why are we lagging behind? The Low-Energy conference has a broad approach: Nigel Jollands from the International Energy Agency -IEA puts energy efficiency in a global perspective. Soeren Rise from Teqniq in Denmark informs about the Danes' energy saving agreement, which appears to have been a success. The conference increased the competencies on concrete energy efficiency solutions, how to speed up the marketing of energy-friendly buildings and technologies, possibilities through industry and the impact of EU-directives and other instruments in order to trigger the potential. The conference closed with a discussion panel of leading energy politicians. The conference contributed to raise the debate in advance of the General election in Norway and the climate negotiations in Copenhagen during the autumn 2009. (EW)

  8. More than just a conference : the European Particule Accelerator Conference, EPAC, has developped a distinctive role on the world stage, explains Christine Petit-Jean-Genaz, the EPAC conferences coordinator

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    More than just a conference : the European Particule Accelerator Conference, EPAC, has developped a distinctive role on the world stage, explains Christine Petit-Jean-Genaz, the EPAC conferences coordinator

  9. 33rd Actinide Separations Conference

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, L M; Wilk, P A

    2009-05-04

    Welcome to the 33rd Actinide Separations Conference hosted this year by the Lawrence Livermore National Laboratory. This annual conference is centered on the idea of networking and communication with scientists from throughout the United States, Britain, France and Japan who have expertise in nuclear material processing. This conference forum provides an excellent opportunity for bringing together experts in the fields of chemistry, nuclear and chemical engineering, and actinide processing to present and discuss experiences, research results, testing and application of actinide separation processes. The exchange of information that will take place between you, and other subject matter experts from around the nation and across the international boundaries, is a critical tool to assist in solving both national and international problems associated with the processing of nuclear materials used for both defense and energy purposes, as well as for the safe disposition of excess nuclear material. Granlibakken is a dedicated conference facility and training campus that is set up to provide the venue that supports communication between scientists and engineers attending the 33rd Actinide Separations Conference. We believe that you will find that Granlibakken and the Lake Tahoe views provide an atmosphere that is stimulating for fruitful discussions between participants from both government and private industry. We thank the Lawrence Livermore National Laboratory and the United States Department of Energy for their support of this conference. We especially thank you, the participants and subject matter experts, for your involvement in the 33rd Actinide Separations Conference.

  10. 33rd Actinide Separations Conference

    International Nuclear Information System (INIS)

    McDonald, L.M.; Wilk, P.A.

    2009-01-01

    Welcome to the 33rd Actinide Separations Conference hosted this year by the Lawrence Livermore National Laboratory. This annual conference is centered on the idea of networking and communication with scientists from throughout the United States, Britain, France and Japan who have expertise in nuclear material processing. This conference forum provides an excellent opportunity for bringing together experts in the fields of chemistry, nuclear and chemical engineering, and actinide processing to present and discuss experiences, research results, testing and application of actinide separation processes. The exchange of information that will take place between you, and other subject matter experts from around the nation and across the international boundaries, is a critical tool to assist in solving both national and international problems associated with the processing of nuclear materials used for both defense and energy purposes, as well as for the safe disposition of excess nuclear material. Granlibakken is a dedicated conference facility and training campus that is set up to provide the venue that supports communication between scientists and engineers attending the 33rd Actinide Separations Conference. We believe that you will find that Granlibakken and the Lake Tahoe views provide an atmosphere that is stimulating for fruitful discussions between participants from both government and private industry. We thank the Lawrence Livermore National Laboratory and the United States Department of Energy for their support of this conference. We especially thank you, the participants and subject matter experts, for your involvement in the 33rd Actinide Separations Conference.

  11. Hamburg Accelerator Conference (2)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Edmund J.N. [CERN Accelerator School (Switzerland)

    1992-11-15

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). The HEACC Conference traditionally reviews the status of all major accelerator projects whether they are already running like clockwork, still in the construction phase, or waiting impatiently for financial approval.

  12. Hamburg Accelerator Conference (2)

    International Nuclear Information System (INIS)

    Wilson, Edmund J.N.

    1992-01-01

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). The HEACC Conference traditionally reviews the status of all major accelerator projects whether they are already running like clockwork, still in the construction phase, or waiting impatiently for financial approval

  13. To conference or not to conference

    African Journals Online (AJOL)

    can travel throughout the world, from Cape to Cairo, from Jakarta to. Istanbul, from San ... Is there any real advantage of going to conferences in the era of electronic ... to register and travel, and the time off work, are justified, although we are.

  14. Otto Toeplitz Memorial Conference

    International Nuclear Information System (INIS)

    Ball, J.A.

    1981-01-01

    A conference in operator theory and its applications commemorating the 100th anniversary of the birth of the distinguished German mathematician Otto Toeplitz, organized by the University of Tel Aviv together with German Mathematical Society, took place in Tel Aviv, Israel, from May 11th to 15th, 1981. I give here a broad very subjective overview of the proceedings of the conference for the benefit of readers of TTSP; for those interested in further details, a forthcoming volume in the Birkhaeuser series Operator Theory: Advances and Applications will consist of expanded written versions of most of the talks given at the conference

  15. Conference Report: The BPS Annual Conference 2004

    Directory of Open Access Journals (Sweden)

    Irina Roncaglia

    2004-05-01

    Full Text Available In this article I will review four papers presented at the British Psychological Society Annual Conference held this year in London held over a 3 day period. The Conference included a variety of scientific presentations and discussions through symposia, roundtable discussions, single papers and poster sessions. Although numerous papers took an experimental approach, few applied any type of qualitative methodology. The topics covered within the different psychological disciplines spanned from early childhood through old age; I have chosen four papers that covered a life course perspective and took into consideration clinical issues as well. The first paper discusses a grounded theory approach used to analyse a play therapy session between therapist and child. The second review reports some recent findings in the way the brains of people on the autistic spectrum disorder might function. The third paper discusses positive psychology and how such an emerging movement has influenced new research in the field. The last paper reviewed will discuss the issue of the ageing process, and I will present some arguments related to the useful application of qualitative methodologies within this area of research. In conclusion, I will highlight some personal reflections on the Conference and the need for a greater balance between qualitative and quantitative methodologies to be used in collaboration rather than as antagonists. URN: urn:nbn:de:0114-fqs0402176

  16. Genome Sequencing and Analysis Conference IV

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    J. Craig Venter and C. Thomas Caskey co-chaired Genome Sequencing and Analysis Conference IV held at Hilton Head, South Carolina from September 26--30, 1992. Venter opened the conference by noting that approximately 400 researchers from 16 nations were present four times as many participants as at Genome Sequencing Conference I in 1989. Venter also introduced the Data Fair, a new component of the conference allowing exchange and on-site computer analysis of unpublished sequence data.

  17. Lift conference | 5-7 February

    CERN Multimedia

    2014-01-01

    Since 2006, Lift Events explore the business and social implications of new technologies through the organisation of international event series and open innovation programs in Europe, Asia and America. The next conference will be held on 5-7 February in Geneva.   (Image: © Lift Conference) The Lift Conference is one of the leading conferences on innovation in Europe and a key annual meeting for individuals and organizations wishing to understand and anticipate trends and innovation. Held every year in February in Geneva (5-7 February 2014), the Lift Conference is a three-day event consisting of talks, interactive workshops, exhibitions, and discussions bringing together over 1’000 participants from all society’s sectors and industries in a dynamic and informal environment with the aim to learn, connect, share and leverage innovation opportunities.   Extraordinary speakers will take to the stage at Lift14: Porter Erisman, former VP of Alibaba.com turned...

  18. 2017 Gordon Conference on Superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Chubukov, Andrey [Univ. of Minnesota, Twin Cities, MN (United States)

    2017-11-14

    The DOE award was for a 2017 Gordon Research conference on Superconductivity (GRC). The objective of GRC is to interchange the information about the latest theoretical and experimental developments in the area of superconductivity and to select most perspective directions for future research in this area.The goal of the Gordon Conference on Superconductivity is to present and discuss the latest results in the field of modern superconductivity, discuss new ideas and new directions of research in the area. It is a long-standing tradition of the Gordon conference on Superconductivity that the vast majority of participants are junior scientists. Funding for the conference would primarily be used to support junior researchers, particularly from under-represented groups. We had more 10 female speakers, some of them junior researchers, and some funding was used to support these speakers. The conference was held together with Gordon Research Seminar on Superconductivity, where almost all speakers and participants were junior scientists.

  19. International Conference on Computational Mechanics

    CERN Document Server

    Atluri, Satya

    1986-01-01

    It is often said that these days there are too many conferences on general areas of computational mechanics. mechanics. and numer ical methods. vJhile this may be true. the his tory of scientific conferences is itself quite short. According to Abraham Pais (in "Subtle is the Lord ...• " Oxford University Press. 1982. p.80). the first international scientific conference ever held was the Karlsruhe Congress of Chemists. 3-5 September 1860 in Karlsruhe. Germany. There were 127 chemists in attendance. and the participants came from Austria. Belgium. France. Germany. Great Britain. Italy. Mexico. Poland. Russia. Spain. Sweden. and Switzerland. At the top of the agenda of the points to be discussed at this conference was the question: "Shall a difference be made between the expressions molecule and atom?" Pais goes on to note: "The conference did not at once succeed in bringing chemists closer together ... It is possible that the older men were offended by the impetuous behavior and imposing manner of the younger...

  20. 4th European Turbulence Conference

    CERN Document Server

    1993-01-01

    The European Turbulence Conferences have been organized under the auspices of the European Mechanics Committee (Euromech) to provide a forum for discussion and exchange of recent and new results in the field of turbulence. The first conference was organized in Lyon in 1986 with 152 participants. The second and third conferences were held in Berlin (1988) and Stockholm (1990) with 165 and 172 participants respectively. The fourth was organized in Delft from 30 June to 3 July 1992 by the J.M. Burgers Centre. There were 214 participants from 22 countries. This steadily growing number of participants demonstrates both the success and need for this type of conference. The main topics of the Fourth European Turbulence Conference were: Dynamical Systems and Transition; Statistical Physics and Turbulence; Experiments and Novel Experimental Techniques; Particles and Bubbles in Turbulence; Simulation Methods; Coherent Structures; Turbulence Modelling and Compressibility Effects. In addition a special session was held o...

  1. 28th Linear Accelerator Conference

    CERN Document Server

    Facco, Alberto; McCausey, Amy; Schaa, Volker R W

    2017-01-01

    The 28th Linear Accelerator Conference, LINAC 16, to take place at the Kellogg Hotel and Conference Center in East Lansing, Michigan, on 25-30 September 2016. This conference is the main bi-yearly gathering for the world-wide community of linac specialists. It provides a unique opportunity to hear about the latest advances of projects and developments concerning hadron and lepton linacs, and their applications. In the tradition of previous LINAC conferences, plenary sessions including invited speakers are scheduled every day. Poster sessions will be held on Monday, Tuesday and Thursday afternoons. There will also be two special events on Sunday, 25 September 2016, namely a student poster session and an evening reception for registrants and their companions at the Kellogg Hotel and Conference Center. Participants are also warmly invited to join an outing to Lake Michigan and the beautiful surroundings on Wednesday afternoon, and to visit the Facility for Rare Isotope Beams on Friday afternoon, after the formal...

  2. Vehicular Networking Conference (VNC)

    NARCIS (Netherlands)

    Altintas, O.; Chen, W.; Heijenk, Geert; Dressler, F.; Ekici, E.; Kargl, Frank; Shigeno, H.; Dietzel, Stefan

    2011-01-01

    On behalf of the Organizing Committee, we would like to welcome you to the third edition of the IEEE Vehicular Networking Conference (IEEE VNC 2011) in Amsterdam, the Netherlands. IEEE VNC is a unique conference sponsored by both the IEEE Communications Society and the IEEE Intelligent

  3. 18th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2014-01-01

    Cryocoolers 18 Cryocoolers 18 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 18th International Cryocooler Conference that was held in Syracuse, New York, on June 9-12, 2014. The program of this conference lead to the 76 peer-reviewed papers that are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  4. 19 CFR 210.35 - Prehearing conferences.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing conferences. 210.35 Section 210.35 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Prehearing Conferences and Hearings § 210.35 Prehearing conferences...

  5. Proceedings of the sixth international conference on fluidized bed combustion. Volume III. Technical sessions

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held April 9-11, 1980, at the Atlanta Hilton, Atlanta, Georgia. It was sponsored by the US Department of Energy, the Electric Power Research Institute, the US Environmental Protection Agency, and the Tennessee Valley Authority. Forty-five papers from Vol. III of the proceedings have been entered individually into EDB and ERA. Two papers had been entered previously from other sources. (LTN)

  6. BEAUTY'99 Conference Summary

    International Nuclear Information System (INIS)

    Eerola, Paula

    2000-01-01

    Investigations of B hadrons are expected to break new ground in measuring CP-violation effects. This series of BEAUTY conferences, originating from the 1993 conference in Liblice, has contributed significantly in developing ideas of CP-violation measurements using B hadrons and formulating and comparing critically the B-physics experiments. In the '99 conference in Bled we saw the ripening of the field and the first fruit emerging - Tevatron have produced beautiful B-physics results and more are expected to come with the next run, while the B-physics experiments at DESY, SLAC and KEK are starting their operation. The longer-term projects at LHC and Tevatron have taken their shape and detailed prototyping work is going on. Meanwhile, on the phenomenological side, there has been impressive theoretical progress in understanding deeper the 'standard' measurements and proposing new signatures. In this summary, I will highlight the status of the field as presented in the conference, concentrating on signatures, experiments and R and D programmes

  7. Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques.

    Directory of Open Access Journals (Sweden)

    Matthew T Aliota

    2016-12-01

    Full Text Available Zika virus (ZIKV; Flaviviridae, Flavivirus was declared a public health emergency of international concern by the World Health Organization (WHO in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the developing fetus. Because development of a ZIKV vaccine is a top research priority and because the genetic and antigenic variability of many RNA viruses limits the effectiveness of vaccines, assessing whether immunity elicited against one ZIKV strain is sufficient to confer broad protection against all ZIKV strains is critical. Recently, in vitro studies demonstrated that ZIKV likely circulates as a single serotype. Here, we demonstrate that immunity elicited by African lineage ZIKV protects rhesus macaques against subsequent infection with Asian lineage ZIKV.Using our recently developed rhesus macaque model of ZIKV infection, we report that the prototypical ZIKV strain MR766 productively infects macaques, and that immunity elicited by MR766 protects macaques against heterologous Asian ZIKV. Furthermore, using next generation deep sequencing, we found in vivo restoration of a putative N-linked glycosylation site upon replication in macaques that is absent in numerous MR766 strains that are widely being used by the research community. This reversion highlights the importance of carefully examining the sequence composition of all viral stocks as well as understanding how passage history may alter a virus from its original form.An effective ZIKV vaccine is needed to prevent infection-associated fetal abnormalities. Macaques whose immune responses were primed by infection with East African ZIKV were completely protected from detectable viremia when subsequently rechallenged with heterologous Asian ZIKV. Therefore, these data suggest that immunogen selection is unlikely to adversely affect the breadth of

  8. Protecting autonomy as authenticity using Ulysses contracts.

    Science.gov (United States)

    van Willigenburg, Theo; Delaere, Patrick

    2005-08-01

    Pre-commitment directives or Ulysses contracts are often defended as instruments that may strengthen the autonomous self-control of episodically disordered psychiatric patients. Autonomy is understood in this context in terms of sovereignty ("governing" or "managing" oneself). After critically analyzing this idea of autonomy in the context of various forms of self-commitment and pre-commitment, we argue that what is at stake in using Ulysses contracts in psychiatry is not autonomy as sovereignty, but autonomy as authenticity. Pre-commitment directives do not function to protect autonomous self-control. They serve in upholding the guidance that is provided by one's deepest identity conferring concerns. We elucidate this concept of autonomy as authenticity, by showing how Ulysses contracts protect the possibility of being "a self."

  9. Conferences as a Dramaturgical Learning Space

    DEFF Research Database (Denmark)

    Hansen, Nicoline Jacoby

    Arguing that conferences are an important but under-researched and under-developed dimension of continuing education, the paper proposes a notion of conferences as a dramatic learning space. Using the design-based research methodology, a theoretical framework drawing on adult learning theories...... and dramaturgy is developed, consisting of four design principles: rhythm, reflection, involvement and interaction. These are sought implemented in a specific conference program, the case of the ECCI X conference, and the final program is explained and discussed....

  10. 6 CFR 13.19 - Prehearing conferences.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Prehearing conferences. 13.19 Section 13.19 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.19 Prehearing conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b...

  11. Visions for a sustainable world: A conference on science, technology and social responsibility. Conference report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This report summarizes the organization, activities, and outcomes of Student Pugwash USA`s 1992 International Conference, Visions for a Sustainable World: A Conference on Science, Technology and Social Responsibility. The conference was held June 14--20, 1992 at Emory University, and brought together 94 students and over 65 experts from industry, academe, and government. The conference addressed issues ranging from global environmental cooperation to the social impacts of the Human Genome Project to minority concerns in the sciences. It provided a valuable forum for talented students and professionals to engage in critical dialogue on many interdisciplinary issues at the juncture of science, technology and society. The conference challenged students -- the world`s future scientists, engineers, and political leaders -- to think broadly about global problems and to devise policy options that are viable and innovative. The success of the conference in stimulating interest, understanding, and enthusiasm about interdisciplinary global issues is clearly evident from both the participants` feedback and their continued involvement in Student Pugwash USA programs. Six working groups met each morning. The working group themes included: environmental challenges for developing countries; energy options: their social and environmental impact; health care in developing countries; changing dynamics of peace and global security; educating for the socially responsible use of technology; ethics and the use of genetic information. The conference was specifically designed to include mechanisms for ensuring its long-term impact. Participants were encouraged to focus on their individual role in helping resolve global issues. This was achieved through each participant`s development of a Personal Plan of Action, a plan which mapped out activities the student could undertake after the conference to continue the dialogue and work towards the resolution of global and local problems.

  12. Early protection events in swine immunized with an experimental live attenuated classical swine fever marker vaccine, FlagT4G.

    Directory of Open Access Journals (Sweden)

    Lauren G Holinka

    Full Text Available Prophylactic vaccination using live attenuated classical swine fever (CSF vaccines has been a very effective method to control the disease in endemic regions and during outbreaks in previously disease-free areas. These vaccines confer effective protection against the disease at early times post-vaccination although the mechanisms mediating the protection are poorly characterized. Here we present the events occurring after the administration of our in-house developed live attenuated marker vaccine, FlagT4Gv. We previously reported that FlagT4Gv intramuscular (IM administered conferred effective protection against intranasal challenge with virulent CSFV (BICv as early as 7 days post-vaccination. Here we report that FlagT4Gv is able to induce protection against disease as early as three days post-vaccination. Immunohistochemical testing of tissues from FlagT4Gv-inoculated animals showed that tonsils were colonized by the vaccine virus by day 3 post-inoculation. There was a complete absence of BICv in tonsils of FlagT4Gv-inoculated animals which had been intranasal (IN challenged with BICv 3 days after FlagT4Gv infection, confirming that FlagT4Gv inoculation confers sterile immunity. Analysis of systemic levels of 19 different cytokines in vaccinated animals demonstrated an increase of IFN-α three days after FlagT4Gv inoculation compared with mock infected controls.

  13. STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice.

    Science.gov (United States)

    Skouboe, Morten K; Knudsen, Alice; Reinert, Line S; Boularan, Cedric; Lioux, Thierry; Perouzel, Eric; Thomsen, Martin K; Paludan, Søren R

    2018-04-01

    In recent years, there has been an increasing interest in immunomodulatory therapy as a means to treat various conditions, including infectious diseases. For instance, Toll-like receptor (TLR) agonists have been evaluated for treatment of genital herpes. However, although the TLR7 agonist imiquimod was shown to have antiviral activity in individual patients, no significant effects were observed in clinical trials, and the compound also exhibited significant side effects, including local inflammation. Cytosolic DNA is detected by the enzyme cyclic GMP-AMP (2'3'-cGAMP) synthase (cGAS) to stimulate antiviral pathways, mainly through induction of type I interferon (IFN)s. cGAS is activated upon DNA binding to produce the cyclic dinucleotide (CDN) 2'3'-cGAMP, which in turn binds and activates the adaptor protein Stimulator of interferon genes (STING), thus triggering type I IFN expression. In contrast to TLRs, STING is expressed broadly, including in epithelial cells. Here we report that natural and non-natural STING agonists strongly induce type I IFNs in human cells and in mice in vivo, without stimulating significant inflammatory gene expression. Systemic treatment with 2'3'-cGAMP reduced genital herpes simplex virus (HSV) 2 replication and improved the clinical outcome of infection. More importantly, local application of CDNs at the genital epithelial surface gave rise to local IFN activity, but only limited systemic responses, and this treatment conferred total protection against disease in both immunocompetent and immunocompromised mice. In direct comparison between CDNs and TLR agonists, only CDNs acted directly on epithelial cells, hence allowing a more rapid and IFN-focused immune response in the vaginal epithelium. Thus, specific activation of the STING pathway in the vagina evokes induction of the IFN system but limited inflammatory responses to allow control of HSV2 infections in vivo.

  14. αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium.

    Directory of Open Access Journals (Sweden)

    Murilo F Roggia

    Full Text Available To elucidate the mechanism of the induction of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α by photoreceptor outer segments (POS and its effects on retinal pigment epithelium (RPE.PGC-1α upregulation by POS was confirmed in ARPE-19 cells and in RPE ex vivo. To elucidate the mechanism, siRNAs against β5 integrin, CD36, Mer tyrosine kinase (MerTK, and Atg5, blocking antibodies against CD36 and MerTK, and a specific inhibitor for focal adhesion kinase (FAK were used. We examined the effect of POS-induced PGC-1α upregulation on the levels of reactive oxygen species (ROS, mitochondrial biogenesis, senescence-associated β-galactosidase (SA-β-gal after H2O2 treatment, and lysosomal activity. Lysosomal activity was evaluated through transcriptional factor EB and its target genes, and the activity of cathepsin D. Lipid metabolism after POS treatment was assessed using Oil Red O and BODIPY C11. RPE phenotypes of PGC-1α-deficient mice were examined.POS-induced PGC-1α upregulation was suppressed by siRNA against β5 integrin and a FAK inhibitor. siRNAs and blocking antibodies against CD36 and MerTK enhanced the effect of POS on PGC-1α. The upregulation of PGC-1α increased the levels of mRNA for antioxidant enzymes and stimulated mitochondrial biogenesis, decreased ROS levels, and reduced SA-β-gal staining in H2O2-treated ARPE-19 cells. PGC-1α was critical for lysosomal activity and lipid metabolism after POS treatment. PGC-1α-deficient mice demonstrated an accumulation of type 2 lysosomes in RPE, thickening of Bruch's membrane, and poor choriocapillaris vasculature.The binding, but not the internalization of POS confers protective effects on RPE cells through the αvβ5 integrin/FAK/PGC-1α pathway.

  15. International Conference on Intelligence and Learning

    CERN Document Server

    Das, J; O’Connor, Neil

    1981-01-01

    This volume contains the Proceedings of an International Conference on Intelligence and Learning held at York University, England, on July 16-20, 1979. The conference was made possible with the support and assistance of the following agencies: NAT 0 Scientific Division, specifically the Human Factors panel, was the major sponsor of the conference. Special thanks are due to Dr. B. A. Bayraktar, who helped organize the conference. Special appreciation is also expressed for the support of the University of York where the conference was held, the University of Alberta, the University of California, Los Angeles, the Medical Research Council, especially its Developmental Psychology Research U nit in London, and the British Council. The conference was jointly directed by J. P. Das and N. 0' Connor. The directors appreciate the assistance in administrative matters of Patricia Chobater and Emma Collins of the University of Alberta. The Editors of the Proceedings acknowledge and appreciate the following individuals who...

  16. Proceedings of the third USGS modeling conference, June 7-11, 2010, Broomfield, Colorado-Understanding and predicting for a changing world

    Science.gov (United States)

    Brady, Shailaja R.

    2011-01-01

    The Third USGS Modeling Conference was held June 7th-11, 2010, in Broomfield, Colorado. The conference focused on the development and application of analytical and theoretical models and data availability that support managing the Nation's resources and help protect lives and property. Participants at the conference included scientists and managers from Department of the Interior (DOI) Bureaus; national and international Federal, State, and local agencies; academic institutions; and nongovernmental organizations. The conference was organized according to DOI priorities and the strategic directions of the USGS Science Strategy; the following themes were emphasized: (1) Understanding Ecosystems and Restoring America's Treasured Landscapes; (2) Climate Change and Impact; (3) New Energy Frontier and Minerals for America; (4) A National Hazards, Risk, and Resilience Assessment Program; (5) Role of Environment and Wildlife in Human Health; (6) A Water Census of the United States; and (7) New Methods of Investigation and Discovery. The conference theme-"Understanding and Predicting for a Changing World"-focused on the following goals: advance development and application of models; provide tools that address management issues; present state-of-the-art models ranging from individual phenomena to integrated systems; and foster a working community among scientists and managers.

  17. Conference Proceedings: Photography and Britishness

    Directory of Open Access Journals (Sweden)

    Sean Willcock

    2016-11-01

    Full Text Available The video-recordings presented here were made at the conference Photography and Britishness, held at the Yale Center for British Art on November 4 – 5, 2016. The conference was the result of a collaboration between the Yale Center for British Art, New Haven, the Paul Mellon Centre for Studies in British Art, London, and the Huntington Library, Art Collections, and Botanical Gardens in San Marino—three research institutions that have a converging interest in British art. The conference sought to investigate the various ways in which notions of “Britishness” have been communicated, inflected, and contested through the photographic image. It was not a conference about the history of photography in Britain, or about British photography. Rather, it sought to consider the nature of the relationship between photography and Britishness: the notion that photography can capture images of Britishness, at the same time that our sense of what Britishness constitutes is produced by the photographic image. A key question for the conference was whether Britishness can have a photographic referent—or whether it is itself an effect of representation. Speakers at the conference approached these questions from a wide range of perspectives and focusing on a diverse number of photographic materials—from family albums and studio portraits to advertisements, reportage, and aerial photography—which demonstrated the complexities and instabilities not only of the term Britishness, but also of the medium of photography. The conference was opened with an introduction by John Tagg. The videos included here are presented in the order they were delivered.

  18. International Conference 'Twenty Years after Chernobyl Accident. Future Outlook'. Abstracts proceeding

    International Nuclear Information System (INIS)

    Anon

    2006-01-01

    This conference concludes a series of events dedicated to the 20 anniversary of the Chernobyl accident and promote an effective implementation of the accumulated international experience in the following areas: Radiation protection of the population and emergency workers, and the environmental consequences of Chernobyl accident; Medical and public health response to radiation emergencies; Strengthening radiological emergency management of radiation accidents; Economic and legal aspects of radioactive waste management and nuclear power plants decommissioning; Radioactive waste management: Chernobyl experience; Nuclear power plant decommissioning: Chernobyl NPP; Transformation of the Chernobyl Sarcophagus into an ecologically safe system

  19. Making Conferences Human Places of Learning

    Science.gov (United States)

    Kenny, Michael

    2014-01-01

    Open Space Technology is a cumbersome name for a participative conference model that enables dynamic inclusive engagement and challenges traditional, highly structured hierarchical conference formats. Based on self-organising systems, (Wenger, 1998) Open Space Technology conferences have an open process, start with no agenda and empower the most…

  20. Approaches to promotion and implementation of action on radiation protection for children

    International Nuclear Information System (INIS)

    Goske, M. J.; Applegate, K. E.; Bulas, D.; Butler, P. F.; Callahan, M. J.; Coley, B. D.; Don, S.; Farley, S.; Frush, D. P.; Hernanz-Schulman, M.; Kaste, S. C.; Morrison, G.; Sidhu, M.; Strauss, K. J.; Treves, S. T.

    2011-01-01

    The Radiation Protection in Medicine conference, reviewed in this journal supplement, outlined nine strategies to promote radiation protection for patients. The Alliance for Radiation Safety in Pediatric Imaging has focused its work on three of those areas: creating awareness of the need and opportunities for radiation protection for children; developing open-source educational materials for medical professionals and parents on this critical topic for improved patient safety and communication; and lastly, advocating on behalf of children with industry, government and regulatory bodies to improve equipment design and safety features, standardisation of nomenclature and displays of dose reports across vendor platforms that reflect the special considerations of children. (authors)