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Sample records for kahler motel hibbing

  1. Generalized Kahler geometry

    CERN Document Server

    Gualtieri, Marco

    2010-01-01

    Generalized Kahler geometry is the natural analogue of Kahler geometry, in the context of generalized complex geometry. Just as we may require a complex structure to be compatible with a Riemannian metric in a way which gives rise to a symplectic form, we may require a generalized complex structure to be compatible with a metric so that it defines a second generalized complex structure. We explore the fundamental aspects of this geometry, including its equivalence with the bi-Hermitian geometry on the target of a 2-dimensional sigma model with (2,2) supersymmetry, as well as the relation to holomorphic Dirac geometry and the resulting derived deformation theory. We also explore the analogy between pre-quantum line bundles and gerbes in the context of generalized Kahler geometry.

  2. Motel en Lainate, Italia

    Directory of Open Access Journals (Sweden)

    Perogalli, Carlo

    1963-03-01

    Full Text Available This Motel occupies a site near the Milan Laghi motorway. Motels are characterised by the type of «cell», or independent apartment, which is a kind of «villa», of easy access, where the car can be parked close by, ready for immediate departure. For this reason this motel has been constructed on one level. Garages are roofed over, and are at street level. The living room is slightly raised, to avoid it being overlooked from outside. The apartments consist of a bedroom, services, and garage. They occupy a double building; the services being separated from the bedroom, to avoid any noise disturbance at the latter. The garages, skew shaped in planform, have a tubular structure, the walls consist of vivid coloured fibrocement, and the roof is made of plastic boards. High intensity night lighting is used, but although everything is clearly visible, it does not disturb those who wish to sleep with windows open. A highly efficient set of services makes this a very functional motel.Está situado cerca de la autopista Milán-Laghi en un amplio solar. Un motel se caracteriza por su «célula» o tipo de apartamento, especie de «villa» con fácil entrada desde el exterior y con el automóvil a mano, para poder salir rápidamente si llega el caso. Estas consideraciones llevaron a adoptar la construcción de una sola planta, con los garajes cubiertos a la altura de la calle, y la habitación ligeramente elevada, con objeto de evitar vistas desde el exterior. Los apartamentos, compuestos por un dormitorio, servicio y garaje para el coche, están dispuestos en un cuerpo doble, y separados de los servicios generales para garantizar tranquilidad a los dormitorios. Los garajes —ladeados en planta— han sido realizados con tubos de hierro; sus paredes llevan láminas de amianto y cemento de colores vivos, y van cubiertos con chapas de plástico. La iluminación nocturna del exterior es de una gran intensidad, pero, a la vez, deja nítido el ambiente, y no

  3. Extremal almost-Kahler metrics

    CERN Document Server

    Lejmi, Mehdi

    2009-01-01

    We generalize the notion of the Futaki invariant and extremal vector field to the general almost-Kahler case and we prove the periodicity of the extremal vector field when the symplectic form represents an integral cohomology class modulo torsion. We give also an explicit formula of the hermitian scalar curvature which allows us to obtain examples of non-integrable extremal almost-Kahler metrics saturating LeBrun's estimates.

  4. Kahler-Einstein and Kahler scalar flat supermanifolds

    CERN Document Server

    Ang, J P; Schulman, John

    2016-01-01

    Two results regarding K\\"ahler supermanifolds with potential $K=A+C\\theta\\bar\\theta$ are shown. First, if the supermanifold is K\\"ahler-Einstein, then its base (the supermanifold of one lower fermionic dimension and with K\\"ahler potential $A$) has constant scalar curvature. As a corollary, every constant scalar curvature K\\"ahler supermanifold has a unique superextension to a K\\"ahler-Einstein supermanifold of one higher fermionic dimension. Second, if the supermanifold is itself scalar flat, then its base satisfies the equation $$ \\phi^{\\bar ji}\\phi_{i\\bar j}=2\\Delta_0 S_0 + R_0^{\\bar ji}R_{0i\\bar j} - S_0^2, $$ where $\\Delta_0$ is the Laplace operator, $S_0$ is the scalar curvature, and $R_{0i\\bar j}$ is the Ricci tensor of the base, and $\\phi$ is some harmonic section on the base. Examples of bosonic manifolds satisfying the equation above are discussed.

  5. Flavour Symmetries and Kahler Operators

    CERN Document Server

    Espinosa, J R

    2004-01-01

    Any supersymmetric mechanism to solve the flavour puzzle would generate mixing both in the superpotential Yukawa couplings and in the Kahler potential. In this paper we study, in a model independent way, the impact of the nontrivial structure of the Kahler potential on the physical mixing matrix, after kinetic terms are canonically normalized. We undertake this analysis both for the quark sector and the neutrino sector. For the quark sector, and in view of the experimental values for the masses and mixing angles, we find that the effects of canonical normalization are subdominant. On the other hand, for the leptonic sector we obtain different conclusions depending on the spectrum of neutrinos. In the hierarchical case we obtain similar conclusion as in the quark sector, whereas in the degenerate and inversely hierarchical case, important changes in the mixing angles could be expected.

  6. Dirac-Kahler Theory and Massless Fields

    CERN Document Server

    Pletyukhov, V A

    2010-01-01

    Three massless limits of the Dirac-Kahler theory are considered. It is shown that the Dirac-Kahler equation for massive particles can be represented as a result of the gauge-invariant mixture (topological interaction) of the above massless fields.

  7. Local Schrodinger flow into Kahler manifolds

    Institute of Scientific and Technical Information of China (English)

    丁伟岳; 王友德

    2001-01-01

    In this paper we show that there exists a unique local smooth solution for the Cauchy problem of the Schrodinger flow for maps from a compact Riemannian manifold into a complete Kahler manifold, or from a Euclidean space Rm into a compact Kahler manifold. As a consequence, we prove that Heisenberg spin system is locally well-posed in the appropriate Sobolev spaces.

  8. Warped K\\"ahler potentials and fluxes

    CERN Document Server

    Martucci, Luca

    2016-01-01

    The four-dimensional effective theory for type IIB warped flux compactifications proposed in [1] is completed by taking into account the backreaction of the K\\"ahler moduli on the three-form fluxes. The only required modification consists in a flux-dependent contribution to the chiral fields parametrising the K\\"ahler moduli. The resulting supersymmetric effective theory satisfies the no-scale condition and consistently combines previous partial results present in the literature. Similar results hold for M-theory warped compactifications on Calabi-Yau fourfolds, whose effective field theory and K\\"ahler potential are also discussed.

  9. Inflation from Nilpotent K\\"ahler Corrections

    CERN Document Server

    McDonough, Evan

    2016-01-01

    We develop a new class of supergravity cosmological models where inflation is induced by terms in the K\\"ahler potential which mix a nilpotent superfield $S$ with a chiral sector $\\Phi$. As the new terms are non-(anti)holomorphic, and hence cannot be removed by a K\\"ahler transformation, these models are intrinsically K\\"ahler potential driven. Such terms could arise for example due to a backreaction of an anti-D3 brane on the string theory bulk geometry. We show that this mechanism is very general and allows for a unified description of inflation and dark energy, with controllable SUSY breaking at the vacuum. When the internal geometry of the bulk field is hyperbolic, we prove that small perturbative K\\"ahler corrections naturally lead to $\\alpha$-attractor behaviour, with inflationary predictions in excellent agreement with the latest Planck data

  10. Generalized Kahler Geometry from supersymmetric sigma models

    CERN Document Server

    Bredthauer, A; Persson, J; Zabzine, M; Bredthauer, Andreas; Lindstrom, Ulf; Persson, Jonas; Zabzine, Maxim

    2006-01-01

    We give a physical derivation of generalized Kahler geometry. Starting from a supersymmetric nonlinear sigma model, we rederive and explain the results of Gualtieri regarding the equivalence between generalized Kahler geometry and the bi-hermitean geometry of Gates-Hull-Rocek. When cast in the language of supersymmetric sigma models, this relation maps precisely to that between the Lagrangian and the Hamiltonian formalisms. We also discuss topological twist in this context.

  11. Blowing up generalized Kahler 4-manifolds

    CERN Document Server

    Cavalcanti, Gil R

    2011-01-01

    We show that the blow-up of a generalized Kahler 4-manifold in a nondegenerate complex point admits a generalized Kahler metric. As with the blow-up of complex surfaces, this metric may be chosen to coincide with the original outside a tubular neighbourhood of the exceptional divisor. To accomplish this, we develop a blow-up operation for bi-Hermitian manifolds.

  12. Hotel and Motel Fire Safety Project - USFA

    Data.gov (United States)

    Department of Homeland Security — Provides a listing of properties compliant with the requirements of the Hotel and Motel Fire Safety Act of 1990. Users may search for compliant properties and submit...

  13. Hotels and Motels - Volusia County Lodging (Points)

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Abstract: This file shows the physical location of known Hotel, Motel, and Bed and Breakfast establishments in Volusia County. This file will be checked at least...

  14. Hotels and Motels - Volusia County Lodging (Points)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Abstract: This file shows the physical location of known Hotel, Motel, and Bed and Breakfast establishments in Volusia County. This file will be checked at least...

  15. 40 CFR 30.18 - Hotel and motel fire safety.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  16. Accidental K\\"ahler Moduli Inflation

    CERN Document Server

    Maharana, Anshuman; Sumitomo, Yoske

    2015-01-01

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small K\\"ahler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil K\\"ahler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model.

  17. Einstein Manifolds and Extremal Kahler Metrics

    CERN Document Server

    LeBrun, Claude

    2010-01-01

    In joint work with Chen and Weber, the author has elsewhere shown that CP2#2(-CP2) admits an Einstein metric. The present paper presents a new and rather different proof of the existence of such an Einstein metric, using a variational approach which simultaneously casts new light on the related uniqueness problem. Our results include new existence theorems for extremal Kahler metrics, and these allow one to prove the above existence statement by deforming the Kahler-Einstein metric on CP2#3(-CP2) until bubbling-off occurs.

  18. Haemophilus influenzae Disease (Including Hib) Symptoms

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... and Symptoms Recommend on Facebook Tweet Share Compartir Haemophilus influenzae , including Hib, disease causes different symptoms depending on ...

  19. Protect Your Child against Hib Disease

    Science.gov (United States)

    ... at 2 and 4 months old. With both vaccines, children need one booster shot when they are 12 ... child has received all scheduled doses of Hib vaccine. All children should get the full series of Hib shots ...

  20. Automorphisms and examples of compact non K\\"ahler manifolds

    CERN Document Server

    Magnússon, Gunnar Þór

    2012-01-01

    Let $X$ be a compact K\\"ahler manifold with zero first Chern class and finite fundamental group. Folklore says that if an automorphism $f$ of $X$ fixes a K\\"ahler class, then its order is finite. We apply this result to construct a compact non K\\"ahler manifold $F$ as a fibration $X \\to F \\to B$ over a complex torus $B$.

  1. Kahler Potential and Ambiguities in 4d N=2 SCFTs

    CERN Document Server

    Gomis, Jaume

    2014-01-01

    The partition function of four-dimensional N=2 superconformal field theories on S^4 computes the exact Kahler potential on the space of exactly marginal couplings [1]. We present a new elementary proof of this result using supersymmetry Ward identities. The partition function is a section rather than a function, and is subject to ambiguities coming from Kahler transformations acting on the Kahler potential. This ambiguity is realized by a local supergravity counterterm in the underlying SCFT. We provide an explicit construction of the Kahler ambiguity counterterm in the four dimensional N=2 off-shell supergravity theory that admits S^4 as a supersymmetric background.

  2. Facts about Hib Disease. ARC Facts.

    Science.gov (United States)

    Association for Retarded Citizens, Arlington, TX.

    The fact sheet provides basic information about Hib Disease in young children, which may involve a bacterial meningitis causing mental retardation, hearing loss, partial blindness, speech disorders, partial paralysis, behavioral problems, or seizures. Stressed is prevention of Hib Disease through immunization. The question and answer format…

  3. Facts about Hib Disease. ARC Facts.

    Science.gov (United States)

    Association for Retarded Citizens, Arlington, TX.

    The fact sheet provides basic information about Hib Disease in young children, which may involve a bacterial meningitis causing mental retardation, hearing loss, partial blindness, speech disorders, partial paralysis, behavioral problems, or seizures. Stressed is prevention of Hib Disease through immunization. The question and answer format…

  4. Hibbing Community College's Community Computer Center.

    Science.gov (United States)

    Regional Technology Strategies, Inc., Carrboro, NC.

    This paper reports on the development of the Community Computer Center (CCC) at Hibbing Community College (HCC) in Minnesota. HCC is located in the largest U.S. iron mining area in the United States. Closures of steel-producing plants are affecting the Hibbing area. Outmigration, particularly of younger workers and their families, has been…

  5. HAMILTONIAN MECHANICS ON K(A)HLER MANIFOLDS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Using the mechanical principle, the theory of modern geometry and advanced calculus, Hamiltonian mechanics was generalized to Kahler manifolds, and the Hamiltonian mechanics on Kahler manifolds was established. Then the complex mathematical aspect of Hamiltonian vector field and Hamilton's equations was obtained, and so on.

  6. Geodesics in the space of K\\"ahler cone metrics

    CERN Document Server

    Calama, Simone

    2012-01-01

    In this paper, we prove the existence and uniqueness of the weak cone geodesics in the space of K\\"ahler cone metrics by solving the singular, homogeneous complex Monge-Amp\\`{e}re equation. As an application, we prove the metric space structure of the appropriate subspace of the space of K\\"ahler cone metrics.

  7. HOTEL AND MOTEL HOUSEKEEPING AIDE, A SUGGESTED TRAINING PROGRAM.

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    A LOCAL TRAINING PROGRAM TO PREPARE HOTEL AND MOTEL HOUSEKEEPING AIDES CAN BE DEVELOPED FROM RESOURCE MATERIAL IN THIS GUIDE. PROGRAM OBJECTIVES ARE TO PREPARE TRAINEES TO PERFORM THE JOBS INVOLVED IN KEEPING HOTEL OR MOTEL ROOMS CLEAN, TO FOLLOW CORRECT PROCEDURES IN USING EQUIPMENT AND SUPPLIES REQUIRED IN CARING FOR BEDROOMS AND BATHROOMS, AND…

  8. Twisted Fock Representations of Noncommutative K\\"ahler Manifolds

    CERN Document Server

    Sako, Akifumi

    2016-01-01

    We introduce twisted Fock representations of noncommutative K\\"ahler manifolds and give their explicit expressions. The twisted Fock representation is a representation of the Heisenberg like algebra whose states are constructed by acting creation operators on a vacuum state. "Twisted" means that creation operators are not hermitian conjugate of annihilation operators in this representation. In deformation quantization of K\\"ahler manifolds with separation of variables formulated by Karabegov, local complex coordinates and partial derivatives of the K\\"ahler potential with respect to coordinates satisfy the commutation relations between the creation and annihilation operators. Based on these relations, we construct the twisted Fock representation of noncommutative K\\"ahler manifolds and give a dictionary to translate between the twisted Fock representations and functions on noncommutative K\\"ahler manifolds concretely.

  9. Kahler stabilized, modular invariant heterotic string models

    Energy Technology Data Exchange (ETDEWEB)

    Gaillard, Mary K.; Gaillard, Mary K.; Nelson, Brent D.

    2007-03-19

    We review the theory and phenomenology of effective supergravity theories based on orbifold compactifications of the weakly-coupled heterotic string. In particular, we consider theories in which the four-dimensional theory displays target space modular invariance and where the dilatonic mode undergoes Kahler stabilization. A self-contained exposition of effective Lagrangian approaches to gaugino condensation and heterotic string theory is presented, leading to the development of the models of Binétruy, Gaillard and Wu. Various aspects of the phenomenology of this class of models are considered. These include issues of supersymmetry breaking and superpartner spectra, the role of anomalous U(1) factors, issues of flavor and R-parity conservation, collider signatures, axion physics, and early universe cosmology. For the vast majority of phenomenological considerations the theories reviewed here compare quite favorably to other string-derived models in the literature. Theoretical objections to the framework and directions for further research are identified and discussed.

  10. Inflating Kahler Moduli and Primordial Magnetic Fields

    CERN Document Server

    Aparicio, Luis

    2016-01-01

    We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual "strong coupling problem" for primordial magnetogesis manifests itself by cycle sizes approaching the string scale, this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  11. Inflating Kahler moduli and primordial magnetic fields

    Directory of Open Access Journals (Sweden)

    Luis Aparicio

    2017-05-01

    Full Text Available We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual “strong coupling problem” for primordial magnetogenesis manifests itself by cycle sizes approaching the string scale; this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  12. Noncommutative Deformations of Locally Symmetric K\\"ahler manifolds

    CERN Document Server

    Hara, Kentaro

    2016-01-01

    We derive algebraic recurrence relations to obtain a deformation quantization with separation of variables for a locally symmetric K\\"ahler manifold. This quantization method is one of the ways to perform a deformation quantization of K\\"ahler manifolds, which is introduced by Karabegov. From the recurrence relations, concrete expressions of star products for one-dimensional local symmetric K\\"ahler manifolds and ${\\mathbb C}P^N$ are constructed. The recurrence relations for a Grassmann manifold $G_{2,2}$ are closely studied too.

  13. Hotels and Motels, Hotel and motels locations with in Johnson County based off of land use, Published in unknown, Johnson County AIMS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hotels and Motels dataset, was produced all or in part from Published Reports/Deeds information as of unknown. It is described as 'Hotel and motels locations...

  14. Local Schrodinger flow into Kahler manifolds

    Institute of Scientific and Technical Information of China (English)

    DlNG; Weiyue(

    2001-01-01

    [1]Ding, W. Y. , Wang, Y. D. , Schrodinger flows of maps into symplectic manifolds, Science in China, Ser. A, 1998, 41(7): 746.[2]Landau, L. D., Lifshitz, E. M., On the theory of the dispersion of magnetic permeability in ferromagnetic bodies, Phys. Z.Sowj., 1935, 8: 153; reproduced in Collected Papers of L. D. Landau, New York: Pergaman Press, 1965, 101-114.[3]Faddeev, L., Takhtajan, L. A. , Hamiltonian Methods in the Theory of Solitons, Berlin-Heidelberg-New York: Springer-Verlag, 1987.[4]Nakamura, K., Sasada, T., Soliton and wave trains in ferromagnets, Phys. Lett. A, 1974, 48: 321.[5]Zhou, Y. , Guo, B. , Tan, S. , Existence and uniqueness of smooth solution for system of ferromagnetic chain, Science in China, Ser. A, 1991, 34(3): 257.[6]Pang, P. , Wang, H. , Wang, Y. D. , Schrodinger flow of maps into Kahler manifolds, Asian J. of Math. , in press.[7]Wang, H. , Wang, Y. D. , Global inhomogeneous Schrodinger flow, Int. J. Math., 2000, 11: 1079.[8]Pang, P., Wang, H., Wang, Y. D., Local existence for inhomogeneous Schrodinger flow of maps into Kahler manifolds,Acta Math. Sinica, English Series, 2000, 16: 487.[9]Temg, C. L., Uhlenbeck, K., Schrodinger flows on Grassmannians, in Integrable Systems, Geometry and Topology,Somervi11e, MA: International Press, in press.[10]Chang, N., Shatah, J., Uhlenbeck, K., Schrodinger maps, Commun. Pure Appl. Math., 2000, 53: 157.[11]Wang, Y. D., Ferromagnetic chain equation from a closed Riemannian manifold into S2, Int. J. Math., 1995, 6: 93.[12]Wang, Y. D., Heisenberg chain systems from compact manifolds into S2, J. Math. Phys., 1998, 39(1): 363.[13]Sulem, P., Sulem, C., Bardos, C., On the continuous limit for a system of classical spins, Commun. Math. Phys., 1986,107: 431.[14]Aubin, T., Nonlinear Analysis on Manifolds, Monge-Ampère Equations, Berlin-Heidelberg-New York: Springer-Verlag,1982.[15]Eells, J. , Lemaire, L. , Another report on harmonic maps, Bull. London

  15. Hib Vaccines: Past, Present, and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Adi Essam Zarei

    2016-01-01

    Full Text Available Haemophilus influenzae type b (Hib causes many severe diseases, including epiglottitis, pneumonia, sepsis, and meningitis. In developed countries, the annual incidence of meningitis caused by bacteria is approximately 5–10 cases per population of 100,000. The Hib conjugate vaccine is considered protective and safe. Adjuvants, molecules that can enhance and/or regulate the fundamental immunogenicity of an antigen, comprise a wide range of diverse compounds. While earlier developments of adjuvants created effective products, there is still a need to create new generations, rationally designed based on recent discoveries in immunology, mainly in innate immunity. Many factors may play a role in the immunogenicity of Hib conjugate vaccines, such as the polysaccharides and proteins carrier used in vaccine construction, as well as the method of conjugation. A Hib conjugate vaccine has been constructed via chemical synthesis of a Hib saccharide antigen. Two models of carbohydrate-protein conjugate have been established, the single ended model (terminal amination-single method and cross-linked lattice matrix (dual amination method. Increased knowledge in the fields of immunology, molecular biology, glycobiology, glycoimmunology, and the biology of infectious microorganisms has led to a dramatic increase in vaccine efficacy.

  16. Haemophilus influenzae Disease (Including Hib) Diagnosis and Treatment

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... Compartir On this Page Diagnosis Treatment Complications Diagnosis Haemophilus influenzae , including Hib, disease is usually diagnosed with one ...

  17. A twistor sphere of generalized Kahler potentials on hyperkahler manifolds

    CERN Document Server

    Dyckmanns, Malte

    2011-01-01

    We consider the generalized Kahler structures (g,J_+,J_-) that arise on a hyperkahler manifold (M,g,I,J,K) when we choose J_+ and J_- from the twistor space of M. We find a relation between semichiral and arctic superfields which can be used to determine the generalized Kahler potential for hyperkahler manifolds whose description in projective superspace is fully understood. We use this relation to determine an S^2-family of generalized Kahler potentials for Euclidean space and for the Eguchi-Hanson geometry. Cotangent bundles of Hermitian symmetric spaces constitute a class of hyperkahler manifolds where our method can be applied immediately since the necessary results from projective superspace are already available. As a non-trivial higher-dimensional example, we determine the generalized potential for T*CP^n, which generalizes the Eguchi-Hanson result.

  18. Open string multi-branched and Kahler potentials

    CERN Document Server

    Carta, Federico; Staessens, Wieland; Zoccarato, Gianluca

    2016-01-01

    We consider type II string compactifications on Calabi-Yau orientifolds with fluxes and D-branes, and analyse the F-term scalar potential that simultaneously involves closed and open string modes. In type IIA models with D6-branes such potential can be directly computed by integrating out Minkowski three-forms. The result shows a multi-branched structure along the space of lifted open string moduli, in which discrete shifts in special Lagrangian and Wilson line deformations are compensated by changes in the RR flux quanta. The same sort of discrete shift symmetries are present in the superpotential and constrain the Kahler potential. As for the latter, inclusion of open string moduli breaks the factorisation between complex structure and Kahler moduli spaces. Nevertheless, the 4d Kahler metrics display a set of interesting relations that allow to rederive the scalar potential analytically. Similar results hold for type IIB flux compactifications with D7-brane Wilson lines.

  19. Cohomological Yang-Mills Theories on Kahler 3-Folds

    NARCIS (Netherlands)

    Hofman, C.; Park, J.S

    2001-01-01

    We study topological gauge theories with N-c = (2, 0) supersymmetry based on stable bundles on general Kahler 3-folds. In order to have a theory that is well defined and well behaved, we consider a model based on an extension of the usual holomorphic bundle by including a holomorphic 3-form. The cor

  20. Explicit Derivation of New Hyper-Kahler metric

    CERN Document Server

    Sedra, M B

    1998-01-01

    Using the harmonic superspace techniques in D=2 N=4, we present an explicit derivation of a new hyper-Kahler metric associated to the Toda like self interaction $H ^{4+}(ømega, u)= (\\frac{\\xi^{++}}{\\lambda})^{2}\\exp(2\\lambda

  1. Haemophilus influenzae Type b (Hib) vaccine - what you need to know

    Science.gov (United States)

    ... taken in its entirety from the CDC Hib (Haemophilus Influenzae Type b) Vaccine Information Statement (VIS): www.cdc. ... statements/hib.pdf . CDC review information for Hib (Haemophilus Influenzae Type b) VIS: Page last reviewed: April 2, ...

  2. The Einstein-Kahler metrics on Cartan-Hartogs domain of the first type

    Institute of Scientific and Technical Information of China (English)

    WANG An

    2004-01-01

    Let YI be the Cartan-Hartogs domain of the first type. We give the generating function of the Einstein-Kahler metrics on YI, the holomorphic sectional curvature of the invariant Einstein-Kahler metrics on YI. The comparison theorem of complete Einstein-Kahler metric and Kobayashi metric on YI is provided for some cases. For the non-homogeneous domain YI, when K = mn+1/m+n, m > 1, the explicit forms of the complete Einstein-Kahler metrics are obtained.

  3. A note on Kahler potential of charged matter in F-theory

    Energy Technology Data Exchange (ETDEWEB)

    Kawano, Teruhiko, E-mail: kawano@hep-th.phys.s.u-tokyo.ac.jp [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Tsuchiya, Yoichi [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Watari, Taizan [Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa-no-ha 5-1-5, 277-8583 (Japan)

    2012-03-19

    We study the Kahler potential of charged matter fields, whose profiles have a peak on their matter curve - on an 'intersection' of 7-branes, in an F-theory compactification. It is shown that the Kahler potential is exactly given by the integral over the matter curve, but not by the integral over the whole GUT surface of 7-branes.

  4. Reheating constraints on K\\"ahler Moduli Inflation

    CERN Document Server

    Kabir, R; Lohiya, D

    2016-01-01

    The end of inflation is connected to the standard cosmological scenario through reheating. During reheating, the inflaton oscillates around the minimum of the potential and thus decays into the daughter particles that populate the Universe at later times. Using cosmological evolution for observable CMB scales from the time of Hubble crossing to the present time, we translate the constraint on the spectral index $n_s$ from Planck data to the constraint on the reheating scenario in the context of K\\"ahler Moduli Inflation. In addition, we extend the de-facto analysis generally done only for the pivot scale to all the observable scales which crossed the Hubble radius during inflation. We study how the maximum number of e-folds varies for different scales, and the effect of the equation of state and potential parameters.

  5. Quaternionic Kahler Manifolds, Constrained Instantons and the Magic Square: I

    CERN Document Server

    Dasgupta, Keshav; Wissanji, Alisha

    2007-01-01

    The classification of homogeneous quaternionic manifolds has been done by Alekseevskii, Wolf et al using transitive solvable group of isometries. These manifolds are not generically symmetric, but there is a subset of quaternionic manifolds that are symmetric and Einstein. A further subset of these manifolds are the magic square manifolds. We show that all the symmetric quaternionic manifolds including the magic square can be succinctly classified by constrained instantons. These instantons are mostly semilocal, and their constructions for the magic square can be done from the corresponding Seiberg-Witten curves for certain N = 2 gauge theories that are in general not asymptotically free. Using these, we give possible constructions, such as the classical moduli space metrics, of constrained instantons with exceptional global symmetries. We also discuss the possibility of realising the Kahler manifolds in the magic square using other solitonic configurations in the theory, and point out an interesting new sequ...

  6. The Einstein-Kahler Metric on the Third Cartan-Hārtogs Domain

    Institute of Scientific and Technical Information of China (English)

    Wen Juan ZHANG; Wei Ping YIN

    2008-01-01

    In this paper we discuss the Einstein-Kahler metric on the third Cartan-Hartogs domain YIII(n,q; K).Firstly we get the complete Einstein-Kahler metric with explicit form on YIII(n,q; K) in the case of K = + Secondly we obtain the holomorphic sectional curvature under this metric and get the sharp estimate for this holomorphic curvature.Finally we prove that the complete Einstein-Kahler metric is equivalent to the Berg-man metric on YIII(n,q; K) in case of K=q/2+1/q-1.

  7. Hotels and Motels, casino hotel data set, Published in 2006, Washoe County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hotels and Motels dataset, was produced all or in part from Published Reports/Deeds information as of 2006. It is described as 'casino hotel data set'. Data by...

  8. Conjugate Points on a Type of K(a)hler Manifolds

    Institute of Scientific and Technical Information of China (English)

    Wei Ming LIU; Fu Sheng DENG

    2013-01-01

    We study conjugate points on a type of K(a)hler manifolds,which are submanifolds of Grassmannian manifolds.And then we give the applications to the study of the index of geodesics and homotopy groups.

  9. On the asymptotic expansion of complete Ricci-flat Kahler metrics on quasi-projective manifolds

    CERN Document Server

    Santoro, Bianca

    2012-01-01

    In this work, we describe the asymptotic behavior of complete metrics with prescribed Ricci curvature on open Kahler manifolds that can be compactified by the addition of a smooth and ample divisor. First, we construct a explicit sequence of Kahler metrics with special approximating properties. Using those metrics as starting point, we are able to work out the asymptotic behavior of the solutions given in the work of Tian-Yau, in particular obtaining their full asymptotic expansion.

  10. Geometric Schr(o)dinger-Airy Flows on K(a)hler Manifolds

    Institute of Scientific and Technical Information of China (English)

    Xiao Wei SUN; You De WANG

    2013-01-01

    We define a class of geometric flows on a complete K(a)hler manifold to unify some physical and mechanical models such as the motion equations of vortex filament,complex-valued mKdV equations,derivative nonlinear Schr(o)dinger equations etc.Furthermore,we consider the existence for these flows from S1 into a complete K(a)hler manifold and prove some local and global existence results.

  11. Coupled equations for K\\"ahler metrics and Yang-Mills connections

    CERN Document Server

    Alvarez-Consul, Luis; Garcia-Prada, Oscar

    2011-01-01

    We study equations on a principal bundle over a compact complex manifold coupling connections on the bundle with K\\"ahler structures in the base. These equations generalize the conditions of constant scalar curvature for a K\\"ahler metric and Hermite-Yang-Mills for a connection. We provide a moment map interpretation of the equations and study obstructions for the existence of solutions, generalizing the Futaki invariant, Mabuchi functional and geodesic stability. We finish by giving some examples of solutions.

  12. Roulette Inflation with K\\"ahler Moduli and their Axions

    CERN Document Server

    Bond, J R; Prokushkin, S F; Vaudrevange, P M

    2006-01-01

    We study 2-field inflation models based on the ``large-volume'' flux compactification of type IIB string theory. The role of the inflaton is played by a K\\"ahler modulus \\tau corresponding to a 4-cycle volume and its axionic partner \\theta. The freedom associated with the choice of Calabi Yau manifold and the non-perturbative effects defining the potential V(\\tau, \\theta) and kinetic parameters of the moduli bring an unavoidable statistical element to theory prior probabilities within the low energy landscape. The further randomness of (\\tau, \\theta) initial conditions allows for a large ensemble of trajectories. Features in the ensemble of histories include ``roulette tractories'', with long-lasting inflations in the direction of the rolling axion, enhanced in number of e-foldings over those restricted to lie in the \\tau-trough. Asymptotic flatness of the potential makes possible an eternal stochastic self-reproducing inflation. A wide variety of potentials and inflaton trajectories agree with the cosmic mic...

  13. Children with Haemophilus influenzae type b (Hib) vaccine failure have long-term bactericidal antibodies against virulent Hib strains with multiple capsular loci.

    Science.gov (United States)

    Townsend-Payne, Kelly; Ladhani, Shamez N; Findlow, Helen; Slack, Mary; Borrow, Ray

    2016-07-25

    Children who develop invasive Haemophilus influenzae serotype b (Hib) disease after immunisation with a highly-effective conjugate vaccine are more likely to have been infected with Hib strains possessing multiple copies of the capsulation locus. Using a recently-validated serum bactericidal antibody (SBA) assay, we tested convalescent sera from 127 Hib vaccine failure cases against clinical Hib strains expressing 1-5 copies of the capsulation locus. SBA titres correlated weakly with anti-capsular IgG antibody concentrations and there was no association between SBA geometric mean titres and number of capsulation locus copies. After infection, children with Hib vaccine failure were equally protected against Hib strains with 1-5 copies of the capsulation locus.

  14. 78 FR 15714 - Welch Motel, Inc., Welch Oil, Inc., Boondocks USA Truck Stop, Bob Welch v. Midland Power...

    Science.gov (United States)

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Welch Motel, Inc., Welch Oil, Inc., Boondocks USA Truck Stop, Bob Welch v... (Commission), 18 CFR 385.206, Welch Motel, Inc., Welch Oil, Inc., Boondocks USA Truck Stop, and Bob...

  15. Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines.

    Science.gov (United States)

    Denoël, Philippe A; Goldblatt, David; de Vleeschauwer, Isabel; Jacquet, Jeanne-Marie; Pichichero, Michael E; Poolman, Jan T

    2007-10-01

    It has been repeatedly observed that mixing Haemophilus influenzae type b (Hib) conjugate vaccines with acellular pertussis-containing vaccines (diphtheria-tetanus-acellular pertussis [DTPa]) resulted in a reduced magnitude of the anti-polyriboseribitolphosphate antibody response compared to that obtained when Hib vaccines were administered separately and not mixed. Nevertheless, the quality and functionality of the immune responses have been shown to be the same. With the purpose of investigating the quality of the anti-Hib immune responses that are elicited under different vaccination regimens, we report here four primary and booster-based pediatric clinical trials in which Hib vaccine was either mixed with DTPa or diphtheria-tetanus-whole-cell pertussis (DTPw)-based vaccines or was coadministered. Our results show that avidity maturation of the antibodies was lower when primary vaccination involved DTPa mixed with Hib compared to when DTPa and Hib were coadministered. No such difference was observed between mixed and separately administered Hib when associated with DTPa-hepatitis B virus-inactivated poliovirus or DTPw-based vaccines. All different combinations and regimens elicited the same opsonophagocytic and bactericidal activity as well as the same ability to protect in a passive infant rat protection assay. The functional activity of mixed DTPa-based and Hib vaccines was similar to that of mixed DTPw-based/Hib combinations. In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children.

  16. Braneworld Inflation in Supergravity with a Shift Symmetric K$\\"{a}$hler Potential

    Indian Academy of Sciences (India)

    Z. Mounzi; M. Ferricha-Alami; A. Safsafi; M. Bennai

    2016-06-01

    We propose a new solution to the $\\eta$-problem in supergravity using a shift symmetric K\\"{a}hler potential in the context of the Randall–Sundrum type II model. We focus on a F-term supergravity inflation with a minimal K\\"{a}hler potential taking into account the radiative corrections. The slow-roll conditions are ensured by the shift symmetry where a very small value of $\\eta$ $(\\eta \\ll 1)$ is obtained. In this context, we derive all known spectrum inflationary parameters which are widely consistent with Planck 2015 data for a particular choice of brane tension and coupling constant values. A suitable observational central value of $n_{s}=0.96$ is also obtained in the case of minimal K$\\"{a}$hler potential.

  17. Coupled equations for K\\"ahler metrics and Yang-Mills connections (Thesis)

    CERN Document Server

    Garcia-Fernandez, Mario

    2011-01-01

    We study equations on a principal bundle over a compact complex manifold coupling connections on the bundle with K\\"ahler structures in the base. These equations generalize the conditions of constant scalar curvature for a K\\"ahler metric and Hermite-Yang-Mills for a connection. We provide a moment map interpretation of the equations and study obstructions for the existence of solutions, generalizing the Futaki character and the Mabuchi K-energy. We explain their relationship to the algebro-geometric moduli problem for pairs consisting of a polarized variety and a holomorphic vector bundle.

  18. The Effective Kahler Potential, Metastable Vacua and R-Symmetry Breaking in O'Raifeartaigh Models

    CERN Document Server

    Benjamin, Shermane; Kain, Ben

    2010-01-01

    Much has been learned about metastable vacua and R-symmetry breaking in O'Raifeartaigh models. Such work has largely been done from the perspective of the superpotential and by including Coleman-Weinberg corrections to the scalar potential. Instead, we consider these ideas from the perspective of the one loop effective Kahler potential. We translate known ideas to this framework and construct convenient formulas for computing individual terms in the expanded effective Kahler potential. We do so for arbitrary R-charge assignments and allow for small R-symmetry violating terms so that both spontaneous and explicit R-symmetry breaking is allowed in our analysis.

  19. Spotlight on DTPa-HBV-IPV/Hib Vaccine (Infanrix hexa).

    Science.gov (United States)

    Dhillon, Sohita

    2010-10-01

    Infanrix hexa, administered intramuscularly, is a diphtheria, tetanus, acellular pertussis, hepatitis B (HBV), inactivated poliomyelitis and Haemophilus influenzae type b (Hib) conjugate vaccine, indicated for primary and booster vaccination of infants. Infanrix hexa should be administered as a two- or three-dose primary vaccination course in infants aged hexa. Infanrix hexa as primary and booster vaccination was safe and highly immunogenic for all its component toxoids/antigens in infants aged hexa elicited a strong immune response against vaccine toxoids/antigens, as indicated by high seroprotection/seropositivity/vaccine response rates and geometric mean titers. Moreover, antibodies against vaccine toxoids/antigens persisted for up to a mean of approximately 6 years after booster vaccination, and the vaccine induced long-term immune memory against hepatitis B surface antigen and Hib antigen. A strong immune response against Infanrix hexa toxoids/antigens after primary vaccination was also induced in infants who had received a dose of HBV vaccine at birth and in pre-term infants, although the response in the latter group was somewhat lower than that in full-term infants. In addition, when coadministered with other childhood vaccines, the immunogenicity of Infanrix hexa or that of the concomitantly administered vaccine was generally not altered. Hexavalent vaccines, including Infanrix hexa, were protective against invasive Hib disease; Infanrix hexa is also expected to be protective against pertussis. Most solicited local and general symptoms with Infanrix hexa were mild to moderate in intensity and the vaccine was associated with few unsolicited adverse events. Available clinical data from more than 10 years' experience with the vaccine suggest that Infanrix hexa as primary and booster vaccination is a safe and useful option for providing protection against the common childhood diseases of diphtheria, tetanus, poliomyelitis, pertussis, hepatitis B and invasive

  20. Non-Kahler Resolved Conifold, Localized Fluxes in M-Theory and Supersymmetry

    CERN Document Server

    Dasgupta, Keshav; McDonough, Evan

    2014-01-01

    The known supergravity solution for wrapped D5-branes on the two-cycle of a Kahler resolved conifold is in general ISD but not supersymmetric, with the supersymmetry being broken by the presence of (1, 2) fluxes. However if we allow a non-Kahler metric on the resolved conifold, supersymmetry can easily be restored. The vanishing of the (1, 2) fluxes here corresponds to, under certain conformal rescalings of the metric, the torsion class constraints. We construct a class of explicit non-Kahler metrics on the resolved conifold satisfying the constraints. All this can also be studied from M-theory, where the fluxes and branes become non-localized G-fluxes on deformed Taub-NUT spaces. Interestingly, the gauge fluctuations on the wrapped D5-branes appear now as localized G-fluxes in M-theory. These localized fluxes are related to certain harmonic two-forms that are normalizable. We compute these forms explicitly and discuss how new constraints on the geometry of the non-Kahler manifolds may appear from M-theory co...

  1. INVARIANT FORM AND INTEGRAL INVARIANTS ON K(A)HLER MANIFOLD

    Institute of Scientific and Technical Information of China (English)

    ZHANG Rong-ye

    2006-01-01

    The important notions and results of the integral invariants of Poincaré and lished first by E. Cartan in the classical mechanics are generalized to Hamilton mechanics on K(a)hler manifold, by the theory of modern geometry and advanced calculus, to get the corresponding wider and deeper results.

  2. Career Preparation for Hotel-Motel Management and Services. Grade 11, Phase I.

    Science.gov (United States)

    Montgomery County Public Schools, Rockville, MD.

    Suggestions arising from a curriculum development workshop led to a curriculum in hotel-motel management and services for high school students which aims to provide them with an opportunity to explore careers in the lodging and hospitality industries. Students will spend half the time in school study of three required subjects and the other half…

  3. Lethal Locations: An Application of Opportunity Theory to Motel Suicide, a Research Note

    Science.gov (United States)

    Wasserman, Ira M.; Stack, Steven

    2008-01-01

    Location of suicide is a neglected area in suicidology, but is important because location is related to the presence of motivated rescuers who can prevent suicides. The present study analyzes the predictors of suicide in a location that is apt to be free of motivated rescuers: the motel room. Data from the files of a medical examiner in a…

  4. Haemophilus Influenzae Type b (Hib) Vaccine: What You Need to Know

    Science.gov (United States)

    VACCINE INFORMATION STATEMENT Hib Vaccine ( Haemophilus Influenzae Type b) What You Need to Know Many Vaccine Information Statements are available in Spanish and other languages. See www. immunize. ...

  5. Economic evaluations of Haemophilus influenzae type b (Hib) vaccine: a systematic review.

    Science.gov (United States)

    Chongmelaxme, Bunchai; Hammanee, Maythika; Phooaphirak, Wariya; Kotirum, Surachai; Hutubessy, Raymond; Chaiyakunapruk, Nathorn

    2017-10-01

    The World Health Organization (WHO) recommends the use of Haemophilus influenzae type b (Hib) conjugate vaccines, but China and Thailand have not used Hib vaccination in their national immunization programs. This systematic review aimed to update published economic evaluations of Hib vaccinations and to determine factors that potentially affected their cost-effectiveness. Searches were performed from the inception until December 2015 using 13 databases: CAB direct; CEA registry; EconLit; EMBASE; E-library; NHSEED; PAHO; POPLINE; PubMed; Redalyc project; RePEc; SciELO; and WHOLIS. Reference lists of relevant studies and grey literature were also searched. Full economic evaluations of Hib vaccination with results of costs and outcomes were included. The WHO checklist was used to evaluate the quality of the included studies. Data from eligible studies were extracted using a standardized data collection form. Out of 830 articles, 27 were included. Almost half of the studies (12/27) were conducted in high-income countries. Twelve studies (12/27) investigated the Hib vaccine as an addition to the existing vaccination program. Most studies (17/27) examined a 3-dose schedule of Hib vaccine. Nineteen studies (19/27) reported the model used, where all were decision tree models. Most of the studies (23/27) demonstrated an economic value of Hib vaccination programs, key influential parameters being incidence rates of Hib disease and vaccine price. Hib vaccination programs are mostly found to be cost-effective across geographic regions and country income levels, and Hib vaccination is recommended for inclusion into all national immunization programs. The findings are expected to support policy-makers for making decisions on allocating limited resources of the Hib vaccination program effectively.

  6. The Dimensional Reduction and K\\"ahler Metric of Forms In Flux and Warping

    CERN Document Server

    Frey, Andrew R

    2013-01-01

    We present a first-principles derivation of the K\\"ahler metric for axion-like moduli of conformally Calabi-Yau compactifications of IIB string theory with imaginary self-dual 3-form flux at the classical level. We find that the warp factor and flux modify the moduli space metric and therefore K\\"ahler potential even in classical supergravity, with the modifications scaling as (volume)$^{-2/3}$ in the large-volume limit. Our derivation emphasizes the role of constraints from 10D gauge symmetries and highlights metric formality as a geometric property that protects the moduli space of highly supersymmetric toroidal orientifolds. Our results have important quantitative implications for nonperturbative moduli stabilization, phenomenology, and cosmology in flux compactifications.

  7. Extremal K\\"ahler metrics on blow-ups of parabolic ruled surfaces

    OpenAIRE

    Tipler, Carl

    2011-01-01

    New examples of extremal K\\"ahler metrics on blow-ups of parabolic ruled surfaces are constructed. The method is based on the gluing construction of Arezzo, Pacard and Singer. This enables to endow ruled surfaces of the form $\\mathbb{P}(\\mathcal{O}\\oplus L)$ with special parabolic structures such that the associated iterated blow-up admits an extremal metric of non-constant scalar curvature.

  8. The One-Loop Effective K\\"ahler Potential. I: Chiral Multiplets

    CERN Document Server

    Flauger, Raphael; Schmidt-Colinet, Cornelius; Sudano, Matthew

    2012-01-01

    We derive a universal formula for the one-loop renormalization of the effective K\\"ahler potential that applies to general supersymmetric effective field theories of chiral multiplets, with arbitrary interactions respecting N=1 supersymmetry in four dimensions. The resulting expression depends only on the tree-level mass spectrum and the form of the regulator. This formula simplifies and generalizes existing results in the literature. We include two examples to illustrate its use.

  9. Lepton Flavour Violation via the K\\"ahler Potential in Compactified M-Theory

    CERN Document Server

    Ellis, Sebastian A R

    2015-01-01

    We use lepton-flavour violating (LFV) processes as a probe of higher-order corrections to the K\\"ahler potential in compactified M-theory. We consider a generic K\\"ahler potential with higher-order terms coupling visible sector fields to fields in the hidden sector of the compactified theory. Such terms generally give rise to potentially large flavour-violating effects. Unless there are suppressions, the size of the resulting off-diagonal terms in the K\\"ahler potential may be at odds with experimental results. The rare decay $\\mu \\to e \\gamma$ and $\\mu \\to e$ conversion in nuclei probe the size of the potential flavour non-diagonality of the higher-order terms for realistic spectra in the M-theory compactification. We consider a parameterisation of the higher-order corrections in terms of a small parameter $\\epsilon$. By analysing various textures for the higher-order corrections, we find current bounds on $\\epsilon$ from the LFV processes. The constraint from the neutral kaon mass difference $\\Delta m_K$ is...

  10. Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers.

    Science.gov (United States)

    Booy, Robert; Richmond, Peter; Nolan, Terry; McVernon, Jodie; Marshall, Helen; Nissen, Michael; Reynolds, Graham; Ziegler, John B; Stoney, Tanya; Heron, Leon; Lambert, Stephen; Mesaros, Narcisa; Peddiraju, Kavitha; Miller, Jacqueline M

    2013-02-01

    Persistence of seroprotective bactericidal antibody titers is important for long-term protection against meningococcal serogroup C disease in young children. Antibody persistence values were determined in children up to 3 years after vaccination with a single dose of the combined Haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C (MenC)-tetanus toxoid (TT) conjugate vaccine (Hib-MenC-TT; www.ClinicalTrials.gov: NCT00326118). The children had been randomized at ages 12-18 months to receive either 1 dose of Hib-MenC-TT (Hib-MenC group) or separately administered Hib-TT conjugate vaccine and MenC-CRM197 (MCC) vaccine (Hib plus MCC group). All children had been primed in infancy with a Hib vaccine. Antibodies against MenC were measured by a serum bactericidal assay using rabbit complement (rSBA-MenC) and antibodies against Hib polyribosylribitol phosphate were assessed by enzyme-linked immunosorbent assay. The rSBA-MenC titers ≥1:8 were demonstrated 3 years after vaccination in 64.2% and 53.2% of participants in the Hib-MenC group and in the Hib plus MCC group, respectively. Antipolyribosylribitol phosphate concentrations ≥0.15 µg/mL persisted in >98% of participants in both groups. The rSBA-MenC geometric mean titers and antipolyribosylribitol phosphate geometric mean concentrations remained higher 3 years after vaccination than before vaccination. No serious adverse events assessed by the investigator as being related to vaccination were reported. In this antibody persistence study of Hib-primed but MenC-naïve toddlers who received a single dose of Hib-MenC-TT, protective antibody levels against Hib and MenC were maintained in the majority of children 3 years after vaccination.

  11. HIB-INFECTION: MENINGITIS, CELLULITIS IN THE CHILD OF 6 MONTHS

    Directory of Open Access Journals (Sweden)

    G. A. Harchenko

    2015-01-01

    Full Text Available A clinical case of Hib-infection is the clinic purulent meningitis and pannikulita young child. Shows the complexity of the differential diagnosis of meningitis in combination with panniculitis with meningococcal disease (meningitis, meningokokktsemiya.

  12. $(k,s)$-positivity and vanishing theorems for compact Kahler manifolds

    CERN Document Server

    Yang, Qi-Lin

    2010-01-01

    We study the $(k,s)$-positivity for holomorphic vector bundles on compact complex manifolds. $(0,s)$-positivity is exactly the Demailly $s$-positivity and a $(k,1)$-positive line bundle is just a $k$-positive line bundle in the sense of Sommese. In this way we get a unified theory for all kinds of positivities used for semipositive vector bundles. Several new vanishing theorems for $(k,s)$-positive vector bundles are proved and the vanishing theorems for $k$-ample vector bundles on projective algebraic manifolds are generalized to $k$-positive vector bundles on compact K\\"ahler manifolds.

  13. Pattern of functional antibody activity against Haemophilus influenzae type b (Hib in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine

    Directory of Open Access Journals (Sweden)

    D.C.S. Matos

    2009-12-01

    Full Text Available We evaluated the functional activity of Haemophilus influenzae B (Hib antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985 were collected for the determination of Hib antibodies. Total Ig and IgM and IgG subclasses of antibodies against polyribosyl ribitol phosphate (PRP were analyzed by ELISA. Almost all vaccinees (97.56%, 961/985 developed a strong anti-PRP IgG antibody response (≥1.0 μg/mL, while an anti-PRP IgM response was observed in 64.24% (634/985 of them (≥0.15 μg/mL. Only 18.88% (186/985 of the infants in the group with high PRP antibody IgG concentrations (≥1.0 μg/mL developed a high IgM antibody response. Anti-PRP IgG antibody levels were significantly higher than anti-PRP IgM. These results demonstrate the predominance of IgG antibodies over IgM antibodies in response to PRP, with a ratio of 17:1. IgG antibodies were predominantly of the IgG1 subclass. An increase in IgG avidity was also observed during the course of immunization.

  14. Pattern of functional antibody activity against Haemophilus influenzae type B (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine.

    Science.gov (United States)

    Matos, D C S; Silva, A M V; Neves, P C C; Martins, R M; Homma, A; Marcovistz, R

    2009-12-01

    We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985) were collected for the determination of Hib antibodies. Total Ig and IgM and IgG subclasses of antibodies against polyribosyl ribitol phosphate (PRP) were analyzed by ELISA. Almost all vaccinees (97.56%, 961/985) developed a strong anti-PRP IgG antibody response (>or=1.0 microg/mL), while an anti-PRP IgM response was observed in 64.24% (634/985) of them (>or=0.15 microg/mL). Only 18.88% (186/985) of the infants in the group with high PRP antibody IgG concentrations (>or=1.0 microg/mL) developed a high IgM antibody response. Anti-PRP IgG antibody levels were significantly higher than anti-PRP IgM. These results demonstrate the predominance of IgG antibodies over IgM antibodies in response to PRP, with a ratio of 17:1. IgG antibodies were predominantly of the IgG1 subclass. An increase in IgG avidity was also observed during the course of immunization.

  15. Lessons learned during the development and transfer of technology related to a new Hib conjugate vaccine to emerging vaccine manufacturers.

    Science.gov (United States)

    Hamidi, A; Boog, C; Jadhav, S; Kreeftenberg, H

    2014-07-16

    The incidence of Haemophilus Influenzae type b (Hib) disease in developed countries has decreased since the introduction of Hib conjugate vaccines in their National Immunization Programs (NIP). In countries where Hib vaccination is not applied routinely, due to limited availability and high cost of the vaccines, invasive Hib disease is still a cause of mortality. Through the development of a production process for a Hib conjugate vaccine and related quality control tests and the transfer of this technology to emerging vaccine manufacturers in developing countries, a substantial contribution was made to the availability and affordability of Hib conjugate vaccines in these countries. Technology transfer is considered to be one of the fastest ways to get access to the technology needed for the production of vaccines. The first Hib conjugate vaccine based on the transferred technology was licensed in 2007, since then more Hib vaccines based on this technology were licensed. This paper describes the successful development and transfer of Hib conjugate vaccine technology to vaccine manufacturers in India, China and Indonesia. By describing the lessons learned in this process, it is hoped that other technology transfer projects can benefit from the knowledge and experience gained.

  16. Disability management practices in education, hotel/motel, and health care workplaces.

    Science.gov (United States)

    Williams, Renee M; Westmorland, Muriel G; Shannon, Harry S; Rasheed, Farah; Amick, Benjamin C

    2005-03-01

    The high costs and the impact of work disability have become a growing concern for workplaces. As a result, workplace disability management approaches have been developed to lower disability costs, protect the employability of workers, and promote early return to work. A stratified random sample of 455 employers in education (n = 157), hotel/motel (n = 110), and health care (n = 188) sectors who completed a mailed Organizational Policies and Practices (OPP) questionnaire is reported. The OPP questionnaire asked questions about eight workplace disability management practices. The article examined the multi-dimensionality, internal consistency, and discriminant validity of the OPP and compares disability management practices across the three sectors. The OPP questionnaire showed good internal consistency (Cronbach's alpha = 0.95) and discriminant validity. A one-way analysis of variance (ANOVA) for each of the eight subscales demonstrated that there were statistically significant differences between the sectors in ergonomic practices (F (2,452) = 15.8, P management (F (2,452) = 4.6, P management practices in education, hotel/motel, and health care sectors, the OPP seems to be a promising instrument that can be used to assess and monitor how employers are managing disability.

  17. Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB).

    Science.gov (United States)

    Bar-On, Edna S; Goldberg, Elad; Hellmann, Sarah; Leibovici, Leonard

    2012-04-18

    Advantages to combining childhood vaccines include reducing the number of visits, injections and patient discomfort, increasing compliance and optimising prevention. The World Health Organization (WHO) recommends that routine infant immunisation programmes include a vaccination against Haemophilus influenzae (H. influenzae) type B (HIB) in the combined diphtheria-tetanus-pertussis (DTP)-hepatitis B virus (HBV) vaccination. The effectiveness and safety of the combined vaccine should be carefully and systematically assessed to ensure its acceptability by the community. To compare the effectiveness of combined DTP-HBV-HIB vaccines versus combined DTP-HBV and separate HIB vaccinations. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4), which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, MEDLINE (January 1966 to week 1, November 2011), EMBASE (January 1990 to November 2011) and www.clinicaltrials.gov (up to April 2011). Randomised controlled trials (RCTs) or quasi-RCTs comparing vaccination with any combined DTP-HBV-HIB vaccine, with or without three types of inactivated polio virus (IPV) or concomitant oral polio vaccine (OPV) in any dose, preparation or time schedule, compared with separate vaccines or placebo, administered to infants up to two years old. Two review authors independently inspected references identified by the searches and evaluated them against the inclusion criteria, extracted data and assessed the methodological quality of included trials. Data for the primary outcome (prevention of disease) were lacking. We performed a meta-analysis to pool the results of 20 studies with 5874 participants in an immunogenicity analysis and 5232 participants in the reactogenicity analysis. There were no data on clinical outcomes for the primary outcome (prevention of disease) and all studies used immunogenicity and reactogenicity (adverse events). The number of vaccine

  18. The existence of Hamiltonian stationary Lagrangian tori in Kahler manifolds of any dimension

    CERN Document Server

    Lee, Yng-Ing

    2010-01-01

    Hamiltonian stationary Lagrangians are Lagrangian submanifolds that are critical points of the volume functional under Hamiltonian deformations. They can be considered as a generalization of special Lagrangians or Lagrangian and minimal submanifolds. Joyce, Schoen and the author show that given any compact rigid Hamiltonian stationary Lagrangian in $\\C^n$, one can always find a family of Hamiltonian stationary Lagrangians of the same type in any compact symplectic manifolds with a compatible metric. The advantage of this result is that it holds in very general classes. But the disadvantage is that we do not know where these examples locate and examples in this family might be far apart. In this paper, we derive a local condition on Kahler manifolds which ensures the existence of one family of Hamiltonian stationary Lagrangian tori near a point with given frame satisfying the criterion. Butscher and Corvino ever proposed a condition in n=2. But our condition appears to be different from theirs. The condition d...

  19. Scalar--flat K\\"ahler metrics with conformal Bianchi V symmetry

    CERN Document Server

    Dunajski, Maciej

    2010-01-01

    We provide an affirmative answer to a question posed by Tod \\cite{Tod:1995b}, and construct all four-dimensional Kahler metrics with vanishing scalar curvature which are invariant under the conformal action of Bianchi V group. The construction is based on the combination of twistor theory and the isomonodromic problem with two double poles. The resulting metrics are non-diagonal in the left-invariant basis and are explicitly given in terms of Bessel functions and their integrals. We also make a connection with the LeBrun ansatz, and characterise the associated solutions of the SU(\\infty) Toda equation by the existence a non-abelian two-dimensional group of point symmetries.

  20. Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil.

    Science.gov (United States)

    Miranzi, Sybelle de Souza Castro; de Moraes, Suzana Alves; de Freitas, Isabel Cristina Martins

    2007-07-01

    This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística--IBGE). Impact was evaluated through a time series analysis (1983-2002), using regression forecasting (RF) by dividing the time series into two periods: (a) historical (1983-1998) and (b) validation (1999-2002). Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.

  1. El motel Vert-Bois en Chalet à Gobet, cerca de Lausana

    Directory of Open Access Journals (Sweden)

    Zapelli, Oswald

    1964-06-01

    Full Text Available This hotel is situated in a privileged position, from which there is a wonderful view of the Alps and the lake. As there is also a well-advertised service station, every incentive is provided for the tourist to make a stop at this Motel. Ample parking space, with a capacity for 80 cars, is provided on each side of the entrance. The restaurant service is the dominant feature of this project: besides a dining room for the guests, there is another one for the general public, as well as a grill room. The bar connects both dining rooms, which are located at different levels. An outdoor gallery and two terraces add to the amenities of the restaurant. The administration and reception offices occupy a separate building nearby. The bedrooms are grouped in two sets, each comprising three buildings, and are arranged unevenly as regards elevation and plan design. They are situated sufficiently far from the main road to provide guests with silence at night. Each apartment has one or two beds and is very comfortably appointed. In one of the groups advantage of the ground slope has been taken, so that the car can be parked beneath the apartment. Sports facilities have been provided to make a stay at this motel even more rewarding: there is a large and two small swimming pools, tennis courts, a horse riding school, and a golf course not far off. In winter, time skiing enthusiasts also take advantage of this fine motel. Altogether it is a most attractive feature for the traveller, who is delighted with the way the buildings harmonise with the local scenery.La situación privilegiada de este complejo hotelero en una zona desde la que se domina una bella vista panorámica de los Alpes y del lago, atrae la atención del turista; y una estación de servicio, con señalización «ad-hoc», invita al conductor a parar. A ambos lados de la entrada se le ofrecen dos grandes aparcamientos con capacidad para 80 coches. El edificio del restaurante constituye el elemento

  2. Solar hot water system installed at Days Inn Motel, Dallas, Texas (Valley View)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    The solar hot water system installed in the Days Inns of America, Inc., Days Inn Motel (120 rooms), I-35/2276 Valley View Lane, Dallas, Texas is described. The solar system was designed by ILI Incorporated to provide 65 percent of the total domestic hot water (DHW) demand. The Solar Energy Products, model CU-30WW liquid (water) flat plate collector (1000 square feet) system automatically drains into the 1000 gallon steel storage tank when the solar pump is not running. This system is one of eleven systems planned. Heat is transferred from the DHW tanks through a shell and tube heat exchanger. A circulating pump between the DHW tanks and heat exchanger enables solar heated water to help make up standby losses. All pumps are controlled by differential temperature controllers. The operation of this system was begun March 11, 1980. The solar components were partly funded ($15,000 of 30,000 cost) by a Department of Energy grant.

  3. Reductions without Regret: Avoiding Wrong Turns, Roach Motels, and Box Canyons

    Energy Technology Data Exchange (ETDEWEB)

    Swegle, John A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Tincher, Douglas J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2013-09-11

    This is the third of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as some closing thoughts for the future. In this paper, we provide one example each of our judgments on what constitutes a box canyon, a roach motel, and a wrong turn: Wrong Turn: The Reliable Replacement Warhead: Roach Motel: SRAM T vs the B61: and A Possible Box Canyon: A Low-Yield Version of the W76 SLBM Warhead. Recognizing that new nuclear missions or weapons are not demanded by current circumstances ₋ a development path that yields future capabilities similar to those of today, which are adequate if not always ideal, and a broader national-security strategy that supports nonproliferation and arms control by reducing the role for, and numbers, of nuclear weapons ₋ we briefly consider alternate, less desirable futures, and their possible effect on the complex problem of regional deterrence. In this regard, we discuss the issues posed by, and possible responses to, three example regional deterrence challenges: in-country defensive use of nuclear weapons by an adversary; reassurance of U.S. allies with limited strategic depth threatened by an emergent nuclear power; and extraterritorial, non-strategic offensive use of nuclear weapons by an adversary in support of limited military objectives against a U.S. ally.

  4. REDUCTIONS WITHOUT REGRET: AVOIDING WRONG TURNS, ROACH MOTELS, AND BOX CANYONS

    Energy Technology Data Exchange (ETDEWEB)

    Swegle, J.; Tincher, D.

    2013-09-11

    This is the third of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as some closing thoughts for the future. In this paper, we provide one example each of our judgments on what constitutes a box canyon, a roach motel, and a wrong turn: � Wrong Turn: The Reliable Replacement Warhead � Roach Motel: SRAM T vs the B61 � A Possible Box Canyon: A Low-Yield Version of the W76 SLBM Warhead Recognizing that new nuclear missions or weapons are not demanded by current circumstances � a development path that yields future capabilities similar to those of today, which are adequate if not always ideal, and a broader national-security strategy that supports nonproliferation and arms control by reducing the role for, and numbers, of nuclear weapons � we briefly consider alternate, less desirable futures, and their possible effect on the complex problem of regional deterrence. In this regard, we discuss the issues posed by, and possible responses to, three example regional deterrence challenges: in-country defensive use of nuclear weapons by an adversary; reassurance of U.S. allies with limited strategic depth threatened by an emergent nuclear power; and extraterritorial, non-strategic offensive use of nuclear weapons by an adversary in support of limited military objectives against a U.S. ally.

  5. N=4 Twisted Superspace from Dirac-Kahler Twist and Off-shell SUSY Invariant Actions in Four Dimensions

    CERN Document Server

    Kato, J; Miyake, A; Kato, Junji; Kawamoto, Noboru; Miyake, Akiko

    2005-01-01

    We propose N=4 twisted superspace formalism in four dimensions by introducing Dirac-Kahler twist. In addition to the BRST charge as a scalar counter part of twisted supercharge we find vector and tensor twisted supercharges. By introducing twisted chiral superfield we explicitly construct off-shell twisted N=4 SUSY invariant action. We can propose variety of supergauge invariant actions by introducing twisted vector superfield. We may, however, need to find further constraints to identify twisted N=4 super Yang-Mills action. We propose a superconnection formalism of twisted superspace where constraints play a crucial role. It turns out that N=4 superalgebra of Dirac-Kahler twist can be decomposed into N=2 sectors. We can then construct twisted N=2 super Yang-Mills actions by the superconnection formalism of twisted superspace in two and four dimensions.

  6. Statistical Distribution of the Vacuum Energy Density in Racetrack K\\"ahler Uplift Models in String Theory

    CERN Document Server

    Sumitomo, Yoske; Wong, Sam S C

    2013-01-01

    We study a racetrack model in the presence of the leading alpha'-correction in flux compactification in Type IIB string theory, for the purpose of getting conceivable de-Sitter vacua in the large compactified volume approximation. Unlike the K\\"ahler Uplift model studied previously, the alpha'-correction is more controllable for the meta-stable de-Sitter vacua in the racetrack case since the constraint on the compactified volume size is very much relaxed. We find that the vacuum energy density \\Lambda for de-Sitter vacua approaches zero exponentially as the volume grows. We also analyze properties of the probability distribution of \\Lambda in this class of models. As in other cases studied earlier, the probability distribution again peaks sharply at \\Lambda=0. We also study the Racetrack K\\"ahler Uplift model in the Swiss-Cheese type model.

  7. Safety and immunogenicity of the DTP/HB /Hib combination vaccine: phase I study

    Directory of Open Access Journals (Sweden)

    Kusnandi Rusmil

    2013-11-01

    Full Text Available Background The World Health Organization (WHO has recommended the introduction of hepatitis B (HB and Haemophilus influenza type b (Hib vaccines into routine childhood vaccination programs. A new diptheria/tetanus/pertussis (DTP/hepatitis B/Hib pentavalent combination vaccine has been developed. Objective To evaluate the safety and immunogenicity of a new combination DTP/HB/Hib liquid vaccine in infants. Methods An open-label, uncontrolled, prospective intervention phase I study was conducted on 30 healthy infants aged 6−11 weeks. Each subject received 3 doses of DTP/HB/Hib vaccine, formulated by Bio Farma, 0.5 mL intramuscularly at the left anterolateral thigh region using a 25-gauge needle of 25 mm length. Subjects were followed for 1 month after administration of each vaccine dose to evaluate its safety, while serum anti-diphteria, tetanus, HBb, Hib, and pertussis antibodies were measured prior to the 1st dose and 1 month after the 3rd dose. Results Among 30 vaccinated subjects, 18 infants had fever within 24 hours after the first vaccination. Most cases of fever were mild in intensity and resolved within 24 hours. No other systemic or local reactions, or serious adverse events were observed in our subjects during the study. The immunogenicity results after 3rd vaccine dose showed that the geometric mean titer of the anti-polyribosylribitol phosphate (PRP antibody levels increased significantly from 0.0041μg/mL to 4.37 μg/mL after vaccination, and most infants had a fourfold or greater rise in antibody levels over their pre-injection levels. All subjects who received DTP/HB/Hib liquid vaccine had seroprotective antibodies against tetanus, diphtheria,a and hepatitis B, while 29/30 infants had seroprotective antibodies against pertussis. Conclusion This new diphtheria/tetanus/pertusis/hepatitis B/Hib combination vaccine has excellent safety profile and antibody responses in infants. These results encourage further clinical evaluation in

  8. Considerations of One-Modulus Calabi-Yau Compactifications Picard-Fuchs Equations, K\\"ahler Potentials and Mirror Maps

    CERN Document Server

    Klemm, A D; Klemm, Albrecht; Theisen, Stefan

    1993-01-01

    We consider Calabi-Yau compactifications with one K\\"ahler modulus. Following the method of Candelas et al. we use the mirror hypothesis to solve the quantum theory exactly in dependence of this modulus by performing the calculation for the corresponding complex structure deformation on the mirror manifold. Here the information is accessible by techniques of classical geometry. It is encoded in the Picard-Fuchs differential equation which has to be supplemented by requirements on the global properties of its solutions.

  9. Some Remarks on Nijenhuis Bracket, Formality, and K\\"ahler Manifolds

    CERN Document Server

    de Bartolomeis, Paolo

    2011-01-01

    One (actually, almost the only effective) way to prove formality of a differentiable manifold is to be able to produce a suitable derivation $\\delta$ such that $d\\delta$-lemma holds. We first show that such derivation $\\delta$ generates a (1,1)-tensor field (we denote it by $R$). Then, we show that the supercommutation of $d$ and $\\delta$ (which is a natural, essentially necessary condition to get a $d\\delta$-lemma) is equivalent to vanishing of the Nijenhujis torsion of $R$. Then, we are looking for sufficient conditions that ensure the $d\\delta$-lemma holds: we consider the cases when $R$ is self adjoint with respect to a Riemannian metric or compatible with an almost symplectic structure. Finally, we show that if $R$ is scew-symmetric with respect to a Riemannian metric, has constant determinant, and if its Nijenhujis torsion vanishes, then the orthogonal component of $R$ in its polar decomposition is a complex structure compatible with the metric, which gives us a new characterization of K\\"ahler structur...

  10. Mirage Models Confront the LHC: I. Kahler-Stabilized Heterotic String Theory

    CERN Document Server

    Kaufman, Bryan L; Gaillard, Mary K

    2013-01-01

    We begin the study of a class of string-motivated effective supergravity theories in light of current data from the CERN Large Hadron Collider (LHC). The case of heterotic string theory, in which the dilaton is stabilized via non-perturbative corrections to the Kahler metric, will be considered first. This model is highly constrained and therefore predictive. We find that much of the reasonable parameter space afforded to the model -- representing the strong dynamics of a presumed gaugino condensation in the hidden sector -- is now observationally disfavored by the LHC results. Most of the theoretically-motivated parameter space that remains can be probed with data that has already been collected, and most of the remainder will be definitively explored within the first year of operation at center of mass energy of 13 TeV. Expected signatures for a number of benchmark points are discussed. We find that the surviving space of the model makes a precise prediction as to the relation of many superpartner masses, a...

  11. Risk behavior for the Human Immunodeficiency Virus among motel clients Las conductas de riesgo al virus de inmunodeficiencia humana entre usuarios de moteles Comportamentos de risco frente ao vírus da imunodeficiência humana entre frequentadores de motéis

    OpenAIRE

    Helisamara Mota Guedes; Luciana Oliveira Costa Cabral; Maria Verônica de Barros Costa; Alex Ferreira dos Reis; Simone Gomes Pereira; Fernanda Oliveira-Ferreira

    2012-01-01

    This study aimed to verify risk behavior for infection with the Human Immunodeficiency Virus in people who attended motels. This is a cross-sectional study conducted in two motels in two municipalities in the state of Minas Gerais, Brazil, with a sample of 308 randomly selected individuals, aged between 18 and 60 years. Bivariate (chi-square and t test for independent samples) and multivariate (logistic regression) statistical tests were performed. A total of 45.8% of the participants reporte...

  12. Solar hot water system installed at Days Inn Motel, Dallas, Texas

    Energy Technology Data Exchange (ETDEWEB)

    1980-09-01

    The solar energy hot water system installed in the Days Inn of America, Inc., Days Inn Motel (100 rooms), I-635/2753 Forrest Lane, Dallas, Texas is described. The solar system was designed by ILI, Inc., to provide 65% of the total Domestic Hot Water (DHW) demand. The liquid flat plate (water) collector is 1000 square feet of solar energy products, Model CU-30W array. Water in the collector system automatically drains into the 1000 gallon steel storage tank located in the mechanical room when the pump is not running. Heat is transferred from the storage tank to DHW tanks through a tube and shell heat exchanger. A circulating pump between the DHW tanks and the heat exchanger enables solar heated water to help make up DHW tank standby losses. All pumps are controlled by differential temperature. Operation of this system was begun March 11, 1980. The solar components were partly funded ($15,000 of $30,000 cost) by the Department of Energy Grant.

  13. Solar hot water system installed at Days Inn Motel, Jacksonville, Florida

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    The solar energy hot water system installed in the Days Inns of America, Inc., Days Inn Motel (120 rooms) I-95 and Cagle Road, Jacksonville, Florida, is described. The solar system was designed by ILI, Incorporated to provide 65 percent of the hot water demand. The system is one of eleven systems planned under this grant. Water (in the Solar Energy Products, Model CU-30ww liquid flat plate collector (900 square feet) system) automatically drains into the 1000 gallon lined and vented steel storage tank when the pump is not running. Heat is transferred from storage to Domestic Hot Water (DHW) tanks through a tube and shell heat exchanger. A circulating pump between the DHW tanks and heat exchanger enables solar heated water to help make up DHW standby losses. All pumps are controlled by differential temperature. This system was turned on June 19, 1979. The solar components were partly funded ($15,823 of $31,823 cost) by the Department of Energy.

  14. Meningococcal groups C and Y and haemophilus B tetanus toxoid conjugate vaccine (HibMenCY-TT; MenHibrix(®)): a review.

    Science.gov (United States)

    Perry, Caroline M

    2013-05-01

    The meningococcal groups C and Y and Haemophilus b (Hib) tetanus toxoid conjugate vaccine (HibMenCY-TT) contains Neisseria meningitidis serogroup C and Y capsular polysaccharide antigens, and Hib capsular polysaccharide [polyribosyl-ribitol-phosphate (PRP)]. The HibMenCY-TT vaccine is available in the USA for use as active immunization to prevent invasive disease caused by N. meningitidis serogroups C (MenC) and Y (MenY), and Hib in children 6 weeks-18 months of age. HibMenCY-TT is the first meningococcal vaccine available for use in the USA that can be administered to infants as young as 6 weeks of age. In a randomized, controlled, phase III clinical trial, the HibMenCY-TT vaccine, administered to infants at 2, 4, 6 and 12-15 months of age, was immunogenic against MenC and MenY, and met the prespecified criteria for immunogenicity. Anti-PRP antibodies, which have been shown to correlate with protection against Hib invasive disease, were also induced in the infants who received the HibMenCY-TT vaccine, with induced levels of this antibody noninferior to those occurring in the control group of infants who received a Hib tetanus toxoid conjugate vaccine at 2, 4, and 6 months and a single dose of Hib conjugated to N. meningitidis outer membrane protein at 12-15 months. In several randomized, controlled clinical trials, HibMenCY-TT was coadministered with vaccines that are routinely administered to infants and toddlers in the USA. These vaccines included: diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine combined; 7-valent Streptococcus pneumoniae polysaccharide conjugate vaccine; measles, mumps and rubella vaccine; and varicella vaccine. Coadministration of these vaccines did not interfere with the immunogenicity of the HibMenCY-TT vaccine. Similarly, immune responses to the coadministered vaccines were not affected by the HibMenCY-TT vaccine. The tolerability profile of the Hib

  15. 41 CFR 301-74.14 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.14 Are there any special requirements for sponsoring or funding a conference at a...

  16. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil

    Science.gov (United States)

    Zanella, Rosemeire Cobo; Brandileone, Maria Cristina de Cunto; Andrade, Ana Lúcia; Ogassavara, Cinthya Terumi; Fiório, Cleiton Eduardo; Brandão, Angela Pires; Almeida, Samanta Cristine Grassi; Lemos, Ana Paula Silva; Gorla, Maria Cecília; Carvalhanas, Telma Regina; Sato, Helena; Liphaus, Bernadete; Nerger, Maria Lígia; Conde, Monica; Ribeiro, Ana Freitas

    2015-01-01

    The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine. PMID:26517654

  17. Hotels and Motels, Located during MicroData field address collection 2004-2006. Kept in Spillman database for retrieval., Published in 2004, Vilas County Land Information/Mapping.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hotels and Motels dataset, was produced all or in part from Field Observation information as of 2004. It is described as 'Located during MicroData field address...

  18. THE SAFETY OF HAEMOPHILUS INFLUENZAE TYPE B/POLYRIBOSYLRIBITOL PHOSPHATE-TETANUS (HIB/PRP-T VACCINE, PHASE I STUDY

    Directory of Open Access Journals (Sweden)

    Kusnandi Rusmil

    2015-09-01

    Full Text Available Objective: To assess the safety and immunogenicity of the Haemophilus influenzae type b/polyribosylribitol phosphate-Tetanus (Hib/PRP-T liquid vaccine in healthy adults. Methods: An open label prospective intervention phase I study was conducted in Dr. Hasan Sadikin General Hospital from November to December 2010. Healthy adults aged 18−40 years were eligible to participate. Participants received one dose of Hib/PRP-T liquid vaccine. Blood samples were taken before, 4 days, and 1 month after vaccination. For a 28-day period following vaccination, solicited adverse events were recorded in the subjects’ diary and assessed afterward. Results: No local reactions or immediate systemic events were observed during the 30-minute period after immunization. There were no serious local or systemic reactions in this study. All of local and systemic reactions observed were slight, transient, self-limiting, and lasting no more than 72 hours after the administration of the vaccine. These reactions resolved without any medical intervention. Hematological and biochemical indices before and 4 days after vaccination were in normal limits. All subjects reached protective levels of antibodies (seroprotectivity against Hib. All subjects demonstrated antibodies performing high bactericidal activities 1 month after immunization. Conclusions: This study demonstrates that liquid Hib/PRP-T vaccine is highly immunogenic and beneficially safe when administered to healthy adults.

  19. Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants

    Directory of Open Access Journals (Sweden)

    Pei-Lan Shao

    2011-06-01

    Full Text Available Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib conjugate vaccine (DTPa-IPV/Hib, Infanrix™-IPV + Hib was assessed when co-administered with hepatitis B (HBV vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15–18 months, and HBV at birth, 1.5, 6 and 15–18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort.

  20. The immunogenicity and safety of a reduced PRP-content DTPw-HBV/Hib vaccine when administered according to the accelerated EPI schedule

    Directory of Open Access Journals (Sweden)

    Collard Alix

    2010-10-01

    Full Text Available Abstract Background Combination vaccines improve coverage, compliance and effectively introduce new antigens to mass vaccination programmes. This was a phase III, observer-blind, randomized study of GSK Biologicals diphtheria-tetanus-whole cell pertussis vaccine combined with hepatitis B and Haemophilus influenzae type b vaccines, containing a reduced amount of polyribosyl-ribitol-phosphate (PRP and a DTPw component manufactured at a different site (DTPw-HBV/Hib2.5 [Kft]. The primary aim of this study was to demonstrate that DTPw-HBV/Hib2.5 [Kft] was not inferior to the licensed DTPw-HBV/Hib (Tritanrix(tm-HepB/Hiberix(tm vaccine or the DTPw-HBV/Hib2.5 vaccine, also containing a reduced amount of PRP, with respect to the immune response to the PRP antigen, when administered to healthy infants, according to the Expanded Programme for Immunization (EPI schedule at 6, 10 and 14 weeks of age. Methods 299 healthy infants were randomised to receive either DTPw-HBV/Hib2.5 [Kft] DTPw-HBV/Hib2.5 or DTPw-HBV/Hib according to the 6-10-14 week EPI schedule. Blood samples were analysed prior to the first dose of study vaccine and one month after the third vaccine dose for the analysis of immune responses. Solicited local and general symptoms such as pain, redness and swelling at the injection site and drowsiness and fever, unsolicited symptoms (defined as any additional adverse event and serious adverse events (SAEs were recorded up to 20 weeks of age. Results One month after the third vaccine dose, 100% of subjects receiving DTPw-HBV/Hib2.5 [Kft] or DTPw-HBV/Hib and 98.8% of subjects receiving DTPw-HBV/Hib2.5 vaccine had seroprotective levels of anti-PRP antibodies (defined as anti-PRP antibody concentration ≥0.15 μg/ml. Seroprotective antibody concentrations were attained in over 98.9% of subjects for diphtheria, tetanus and hepatitis B. The vaccine response rate to pertussis antigen was at least 97.8% in each group. Overall, the DTPw-HBV/Hib2.5 [Kft

  1. 设施简单服务良好——记经济等饭店中的佼佼者Motel 6

    Institute of Scientific and Technical Information of China (English)

    钱炜

    2001-01-01

    《洛杉矶时报》“旅游”专栏最近进行读者调查,题为“你最喜欢的饭店”(Your Favorite Hotels)。调查结果公布,在经济等饭店中,Motel 6(直译为“6美元汽车旅馆)独占鳌头。

  2. Simultaneous vaccination with MMR and DTaP-IPV-Hib and rate of hospital admissions with any infections

    DEFF Research Database (Denmark)

    Sørup, Signe; Benn, Christine S; Poulsen, Anja

    2016-01-01

    and inactivated vaccines may increase child mortality compared with the live vaccine alone. We examined the hypothesis that simultaneous administration of MMR and the inactivated DTaP-IPV-Hib vaccine compared with MMR alone is associated with higher incidence of infectious disease admissions. METHODS: Nationwide......BACKGROUND: In Denmark, live measles, mumps, and rubella vaccine (MMR) is associated with a reduced risk of infectious disease admissions, particularly for lower respiratory tract infections. In low-income countries, simultaneous vaccination (i.e. vaccination at the same visit) with live......, 4965 children had simultaneous MMR and DTaP-IPV-Hib as their most recent vaccination. Compared with MMR alone, simultaneous administration was associated with a higher rate of lower respiratory tract infections (adjusted incidence rate ratio (IRR), 1.27; 95% confidence interval (CI), 1...

  3. Fully liquid DTaP-IPV-Hib pediatric combination vaccine (Pediacel): a review of 18 years of clinical experience.

    Science.gov (United States)

    Reynolds, Donna L; Vidor, Emmanuel

    2014-08-01

    Safe and effective combination pediatric vaccines are necessary to simplify complex immunization schedules and to improve coverage and protection for children worldwide. We provide an overview of the 18 years of clinical and worldwide experience with DTaP-IPV-Hib (Pediacel(®)), a unique fully liquid pentavalent vaccine (diphtheria [D], tetanus [T], acellular pertussis, inactivated poliovirus [IPV], Haemophilus influenzae type b [Hib]). Pediacel has demonstrated good and lasting immunogenicity in many populations, with differing primary series and booster schedules, and with a variety of coadministered vaccines. The acellular pertussis antigens have proven efficacy and real-world effectiveness. Clinical and post-marketing studies confirm the safety of Pediacel. Pediacel can be used for primary series and toddler booster doses, as well as in mixed pediatric vaccine schedules.

  4. DTPa-HBV-IPV/Hib Vaccine (Infanrix hexa): A Review of its Use as Primary and Booster Vaccination.

    Science.gov (United States)

    Dhillon, Sohita

    2010-05-28

    Infanrix hexa, administered intramuscularly, is a diphtheria, tetanus, acellular pertussis, hepatitis B (HBV), inactivated poliomyelitis and Haemophilus influenzae type b (Hib) conjugate vaccine, indicated for primary and booster vaccination of infants. Infanrix hexa should be administered as a two- or three-dose primary vaccination course in infants aged hexa. Infanrix hexa as primary and booster vaccination was safe and highly immunogenic for all its component toxoids/antigens in infants aged hexa elicited a strong immune response against vaccine toxoids/antigens, as indicated by high seroprotection/seropositivity/vaccine response rates and geometric mean titres. Moreover, antibodies against vaccine toxoids/antigens persisted for up to a mean of approximately 6 years after booster vaccination, and the vaccine induced long-term immune memory against hepatitis B surface antigen and Hib antigen. A strong immune response against Infanrix hexa toxoids/antigens after primary vaccination was also induced in infants who had received a dose of HBV vaccine at birth and in pre-term infants, although the response in the latter group was somewhat lower than that in full-term infants. In addition, when coadministered with other childhood vaccines, the immunogenicity of Infanrix hexa or that of the concomitantly administered vaccine was generally not altered. Hexavalent vaccines, including Infanrix hexa, were protective against invasive Hib disease; Infanrix hexa is also expected to be protective against pertussis. Most solicited local and general symptoms with Infanrix hexa were mild to moderate in intensity and the vaccine was associated with few unsolicited adverse events. Available clinical data from more than 10 years' experience with the vaccine suggest that Infanrix hexa as primary and booster vaccination is a safe and useful option for providing protection against the common childhood diseases of diphtheria, tetanus, poliomyelitis, pertussis, hepatitis B and invasive

  5. Analysis of Micro-texture during Secondary Recrystallization in a Hi-B Electrical Steel

    Institute of Scientific and Technical Information of China (English)

    Mengqi Yan; Hao Qian; Ping Yang; Weimin Mao; Qiwu Jian; Wenxu Jin

    2011-01-01

    The understanding of Goss texture in Hi-B electrical steels possesses significant industrial and academic value, thus attracts worldwide attention. The prevailing models for sharp Goss texture formation during secondary recrystallization are CSL (coincident site lattice) boundary theory and HE (high energy) boundary theory. These theories stress the key factor of preferred growth and the difference between them only lies in the specific selection manner. This work examined the texture gradient in primarily recrystallized sheet and demonstrated its possible influence on the formation of secondary grains, and then determined the micro- texture during different stages of secondary recrystallization using EI3SD (electron back-scattered diffraction) technique, finally analyzed a special type of secondary grains with near Brass orientation, which were detected in the later stage of secondary recrystallization, and discussed its origin and effect in terms of surface energy effect. The results indicate that texture gradient in primarily recrystallized sheet will lead to a multi-stage formation of Goss texture, namely, early stage of secondary grains with various orientations in subsurface region, intermediate stage of preferred growth of Goss grains into center layer and re-grow back to the surface and the final stage of Goss grain growth by swallowing slowly the island grains with the help of H2 atmosphere.

  6. The simulation of multiple scattering and its effect on the detection limit of HIBS

    Energy Technology Data Exchange (ETDEWEB)

    Li, M.M.; O`Connor, D.J. [Newcastle University, Newcastle, NSW (Australia). Dept. of Physics

    1998-06-01

    With the development of heavy ion backscattering spectrometry (HIBS) for the detection of trace impurities, it is necessary to quantify the multiple scattering contributions to the spectral background. In the present work, the Monte Carlo computer simulation program TRIM has been used to study the backscattering spectrum and the multiple scattering features for heavy ions C, Ne, Si, Ar and Kr impinging on four types of targets: a very thin layer Au with thickness of 10 Angstroms, a 10 Angstroms Au thin layer covering a 50 Angstroms Si thick layer, a 10 Angstroms Au thin layer covering on Si substrate (10000 Angstroms), and a thick target of pure Si with thickness of 10000 Angstroms. By fitting the simulation results we have derived the ratio of signal from the thin Au layer to the background due to multiple scattering. From the simulation results, we found that the Si substrate plays a role in generating the low energy background tail due to ion`s multiple scattering in the substrate. Such a background is generated neither by the thin Au layer nor by the pure Si substrate independently. The corresponding mechanism of multiple scattering in the target can be explained as one large-angle scattering event in Au layer and subsequently several small angle scattering events in the substrate. (authors). 4 refs., 1 tab., 3 figs.

  7. Randomized, Controlled, Multicenter Study of the Immunogenicity and Safety of a Fully Liquid Combination Diphtheria–Tetanus Toxoid–Five-Component Acellular Pertussis (DTaP5), Inactivated Poliovirus (IPV), and Haemophilus influenzae Type b (Hib) Vaccine Compared with a DTaP3-IPV/Hib Vaccine Administered at 3, 5, and 12 Months of Age

    Science.gov (United States)

    Silfverdal, Sven Arne; Boisnard, Florence; Thomas, Stéphane; Mwawasi, Grace; Reynolds, Donna

    2013-01-01

    This study compared the levels of immunogenicity and safety of diphtheria–tetanus toxoid–five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and Haemophilus influenzae type b (Hib) (DTaP5-IPV-Hib) and DTaP3-IPV/Hib vaccines for study participants 3, 5, and 12 months of age. Post-dose 3 noninferiority criteria comparing DTaP5-IPV-Hib to DTaP3-IPV/Hib using rates of seroprotection were demonstrated against diphtheria, tetanus, and polio types 1 to 3, but not for polyribosylribitol phosphate (PRP). While PRP did not meet noninferiority criteria, the seroprotection rate and geometric mean concentration (GMC) were high, indicating a clinically robust immune response. GMCs or titers for other antigens (including pertussis) and the safety profiles were generally similar between groups. Fully liquid DTaP5-IPV-Hib can be administered using the 3-, 5-, and 12-month vaccination schedule. (This study has been registered at ClinicalTrials.gov under registration no. NCT00287092.) PMID:23966556

  8. Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age.

    Science.gov (United States)

    Vesikari, Timo; Silfverdal, Sven Arne; Boisnard, Florence; Thomas, Stéphane; Mwawasi, Grace; Reynolds, Donna

    2013-10-01

    This study compared the levels of immunogenicity and safety of diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP(5)), inactivated poliovirus (IPV), and Haemophilus influenzae type b (Hib) (DTaP(5)-IPV-Hib) and DTaP(3)-IPV/Hib vaccines for study participants 3, 5, and 12 months of age. Post-dose 3 noninferiority criteria comparing DTaP(5)-IPV-Hib to DTaP(3)-IPV/Hib using rates of seroprotection were demonstrated against diphtheria, tetanus, and polio types 1 to 3, but not for polyribosylribitol phosphate (PRP). While PRP did not meet noninferiority criteria, the seroprotection rate and geometric mean concentration (GMC) were high, indicating a clinically robust immune response. GMCs or titers for other antigens (including pertussis) and the safety profiles were generally similar between groups. Fully liquid DTaP(5)-IPV-Hib can be administered using the 3-, 5-, and 12-month vaccination schedule. (This study has been registered at ClinicalTrials.gov under registration no. NCT00287092.).

  9. High pneumonia lifetime-ever incidence in Beijing children compared with locations in other countries, and implications for national PCV and Hib vaccination

    Science.gov (United States)

    Qu, Fang; Sun, Yuexia; Sundell, Jan

    2017-01-01

    Objectives To compare the proportion of Beijing children who have ever had pneumonia (%Pneumonia) to those in other locations, and to estimate by how much national vaccine coverage with Pneumococcal Conjugate Vaccine (PCV) and Haemophilus Influenzae Type b (Hib) could reduce Beijing %Pneumonia. Methods %Pneumonia was obtained for each age group from 1 to 8 years inclusive from 5,876 responses to a cross-sectional questionnaire. Literature searches were conducted for world-wide reports of %Pneumonia. Previous vaccine trials conducted worldwide were used to estimate the pneumococcal (S. pneumoniae) and Hib (H. influenzae) burdens and %Pneumonia as well as the potential for PCV and Hib vaccines to reduce Beijing children’s %Pneumonia. Findings The majority of pneumonia cases occurred by the age of three. The cumulative %Pneumonia for 3–8 year-old Beijing children, 26.9%, was only slightly higher than the 25.4% for the discrete 3 year-old age group, similar to trends for Tianjin (China) and Texas (USA). Beijing’s %Pneumonia is disproportionally high relative to its Gross National Income (GNI) per capita, and markedly higher than %Pneumonia in the US and other high GNI per capita countries. Chinese diagnostic guidelines recommend chest X-ray confirmation while most other countries discourage it in favor of clinical diagnosis. Literature review shows that chest X-ray confirmation returns far fewer pneumonia diagnoses than clinical diagnosis. Accordingly, Beijing’s %Pneumonia is likely higher than indicated by raw numbers. Vaccine trials suggest that national PCV and Hib vaccination could reduce Beijing’s %Pneumonia from 26.9% to 19.7% and 24.9% respectively. Conclusion National PCV and Hib vaccination programs would substantially reduce Beijing children’s pneumonia incidence. PMID:28166256

  10. Psicose e Bates Motel: similaridades na transposição da narrativa do filme para o seriado de televisão

    Directory of Open Access Journals (Sweden)

    Rafael Jose Bona

    2016-12-01

    Full Text Available Analisa-se a transposição da narrativa cinematográfica para a televisiva em relação ao filme Psicose (1960, Alfred Hitchcock e o seriado Bates Motel (2013. Foi feito um estudo de elementos a partir da estética, da narrativa e da técnica audiovisual. A pesquisa é de caráter descritiva e analítica, com abordagem qualitativa. Como resultado foi possível obter maior entendimento na transposição de personagens do cinema para a televisão, assim como uma visão crítica a respeito das similaridades das produções audiovisuais.

  11. Safety, immunogenicity and persistence of immune response to the combined diphtheria, tetanus, acellular pertussis, poliovirus and Haemophilus influenzae type b conjugate vaccine (DTPa-IPV/Hib) administered in Chinese infants

    Science.gov (United States)

    Li, Yanping; Li, Rong Cheng; Ye, Qiang; Li, Changgui; Liu, You Ping; Ma, Xiao; Li, Yanan; Zhao, Hong; Chen, Xiaoling; Assudani, Deepak; Karkada, Naveen; Han, Htay Htay; Van Der Meeren, Olivier; Mesaros, Narcisa

    2017-01-01

    ABSTRACT We conducted 3 phase III, randomized, open-label, clinical trials assessing the safety, reactogenicity (all studies), immunogenicity (Primary vaccination study) and persistence of immune responses (Booster study) to the combined diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b vaccine (DTPa-IPV/Hib) in Chinese infants and toddlers. In the Pilot study (NCT00964028), 50 infants (randomized 1:1) received 3 doses of DTPa-IPV/Hib at 2–3–4 (Group A) or 3–4–5 months of age (Group B). In the Primary study (NCT01086423), 984 healthy infants (randomized 1:1:1) received 3 doses of DTPa-IPV/Hib at 2–3–4 (Group A) or 3–4–5 (Group B) months of age, or concomitant DTPa/Hib and poliomyelitis (IPV) vaccination at 2–3–4 months of age (Control group); 825 infants received a booster dose of DTPa/Hib and IPV at 18–24 months of age (Booster study; NCT01449812). In the Pilot study, unsolicited symptoms were more frequent in Group A (16 versus 1 infant; mostly upper respiratory tract infection and pyrexia); this observation was attributed to an epidemic outbreak of viral infections. Non-inferiority of 3-dose primary vaccination with DTPa-IPV/Hib over separately administered DTPa/Hib and IPV was demonstrated for Group A (primary objective). Similar antibody concentrations were observed in all groups, except for anti-polyribosyl-ribitol phosphate and anti-poliovirus types 1–3 which were higher in DTPa-IPV/Hib recipients. Protective antibody levels against all vaccine antigens remained high until booster vaccination. Three-dose vaccination with DTPa-IPV/Hib had a clinically acceptable safety profile. PMID:27768515

  12. PENDAPAT AL-MAZÂHIB AL-ARBA’AH TENTANG BENTUK SYIRKAH DAN APLIKASINYA DALAM PERSEROAN MODERN

    Directory of Open Access Journals (Sweden)

    Burhanuddin Susamto

    2014-06-01

    Full Text Available The practice of sharia principles in our life is a necessity. A corporation as a part of life is not out of the frame of sharia perspective. The desire to view  the corporation  from the sharia perspective is starting  from the fact that in fiqh muamalah there are some  relevant  contract,  especially  syirkah  contract. Al-mazâhib al-arba'ah through their  books of fiqh  have introduced the similarities and differences of opinion concerning shirkah forms which original law is  allowed according to the Qur'an, the Sunnah and ijma '. Therefore, through this article, the author will reveal again the opinion of the each  schools concerning syirkah  forms and how to implement it in the context of a modern corporation.

  13. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study.

    Science.gov (United States)

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2016-03-03

    The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese children vaccine. DTPa-IPV/Hib conjugate vaccine was well tolerated as a booster dose in healthy Vietnamese children aged <2 years.

  14. A randomized, dose-ranging assessment of the immunogenicity and safety of a booster dose of a combined diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b (DTPw-HBV-IPV/Hib) vaccine vs. co-administration of DTPw-HBV/Hib and IPV vaccines in 12 to 24 months old Filipino toddlers.

    Science.gov (United States)

    Quiambao, Beatriz; Van Der Meeren, Olivier; Kolhe, Devayani; Gatchalian, Salvacion

    2012-03-01

    As progress toward global poliovirus eradication continues, more and more countries are moving away from use of oral poliovirus vaccines (OPV) to inactivated poliovirus vaccines (IPV) in national vaccination schedules. Reduction of antigen dose in IPV could increase manufacturing capacity and facilitate the change from OPV to IPV. Combination vaccines reduce the number of injections required to complete vaccination, thus playing an important role in maintaining high vaccine coverage with good public acceptability. Three formulations of a combined, candidate hexavalent diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b conjugate vaccine (DTPw-HBV-IPV/Hib, GlaxoSmithKline Biologicals) differing only in IPV antigen content (full-dose, half-dose and one-third dose as compared with available stand-alone IPV vaccines), were evaluated when administered to healthy toddlers. Controls received separately administered licensed DTPw-HBV/Hib and IPV vaccines. Immunogenicity was assessed before and one month after vaccination. Safety and reactogenicity data were assessed for 30 d after vaccination. A total of 312 Filipino children were vaccinated in their second year of life. Each DTPw-HBV-IPV/Hib formulation was non-inferior to control in terms of pre-defined criteria for IPV immunogenicity. Post-vaccination GMTs against each poliovirus type were increased between 4.2- and 37.9-fold over pre-vaccination titers. Non-inferiority to other vaccine antigens was also demonstrated. The safety profile of the 3 DTPw-HBV-IPV/Hib formulations resembled licensed DTPw-HBV/Hib Kft and IPV in terms of the frequency and intensity of adverse reactions after vaccination. Further investigation of DTPw-HBV-IPV/Hib containing reduced quantity of IPV antigen for primary vaccination in infants is warranted. This study is registered at www.clinicaltrials.gov NCT number: NCT01106092.

  15. Estudio de factibilidad para la comercialización y distribución de sabanas y fundas desechables para los moteles de mediana y alta categoría en la ciudad de Bogotá

    OpenAIRE

    Vigoya Barreto, Víctor Alfonso; Lara Rodríguez, Diego Fernando

    2012-01-01

    En el presente trabajo de investigación se desarrolla un estudio de factibilidad comercial y financiera sobre la venta de sabanas y fundas desechables, las cuales ya se comercializan ampliamente en países Europeos, con este estudio se quiere concluir si en la ciudad de Bogotá – Colombia es viable la distribución de estos productos para el mercado de los moteles de alta y mediana categoría.

  16. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study

    OpenAIRE

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2015-01-01

    abstract The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese ch...

  17. 市场细分下广州发展汽车旅馆的可行性分析研究∗%Feasibility Analysis of the Development of Motel under Market Segments in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    陈枫艺

    2016-01-01

    汽车旅馆是西方国家较为风靡的一种饭店类型,由于它集经济,舒适和便利为一体的特点,深受民众喜爱并成为人们旅游生活中不可缺少的一部分。在经济发展快速的中国大城市———广州已经具备有发展汽车旅馆经济的软硬条件。因此,在广州发展汽车旅游酒店是可行的。%Motel is a type of hotel which is so popular in western countries, because it is economical, comfortable and convenient, and especially loved by the public and becomes a necessary part of tourist life. Guangzhou that is rapid economic development in China already has conditions to the develop motels industry. Therefore development of Motel industry in Guangzhou is feasible.

  18. Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age Estudo de viabilidade de imunogenicidade e segurança de uma nova vacina brasileira combinada DTPw/Hib (PRP-T, comparada com uma vacina registrada, em crianças de 2, 4 e 6 meses de idade

    Directory of Open Access Journals (Sweden)

    SueAnn Costa Clemens

    2003-06-01

    Full Text Available Vaccination of infants with conjugated Haemophilus influenzae type b (Hib vaccines has been proven to reduce Hib meningitis by 95% and pneumoniae by 20%. The routine use of Hib vaccine is facilitated by the introduction of combination vaccines into the EPI (Expanded Plan of Immunization. The objective of this study was to compare the immunogenicity and reactogenicity of an extemporaneously mixed DTPw/Hib (diphtheria-tetanus-whole cell pertussis combination, using the technology of two Brazilian manufacturers, against a licensed DTPw/Hib European combination in 108 infants vaccinated at 2, 4 and 6 months according to the local national schedule. The Brazilian combination was highly immunogenic with Hib seroprotection rates (anti-PRP > 0.15 mg /ml of 98% after 2 doses and 100% after 3. Also for tetanus and pertussis the new Brazilian combination was as immunogenic as the European counterpart, except the diphtheria seroprotection rates and titers were lower. There was also no clinically relevant difference in reactogenicity. If these feasibility results are confirmed, the Brazilian DTPw/Hib combination should help to boost the uptake of Hib vaccination in Brazil.A vacinação contra (Haemophilus influenzae tipo b (Hib, utilizando vacinas conjugadas, provou reduzir em 95% os casos de meningite e em 20% as pneumonias por Hib. O uso rotineiro da vacina Hib foi facilitado pela introdução das vacinas combinadas no Programa Ampliado de Imunização (PAI. O objetivo deste estudo foi comparar a imunogenicidade e reatogenicidade da mistura extemporânea da vacina combinada contra difteria-tétano-pertussis de células inteiras/Haemophilus influenzae (DTPw/Hib, de tecnologia e produção de 2 fabricantes brasileiros, à vacina européia registrada DTPw/Hib. Estudo realizado em 108 crianças em idade de 2, 4 e 6 meses, seguindo o esquema nacional de imunização. A vacina combinada brasileira foi altamente imunogênica, apresentando taxas de soroprote

  19. 儿童分次注射IPV、Hib和DTaP疫苗与注射联合疫苗的对比分析%Comparative analysis of the side effects of DTaP-IPV/Hib combined vaccine with injection of DTaP,IPV and Hib separately in healthy Chinese infants

    Institute of Scientific and Technical Information of China (English)

    陈杰; 刘芳; 石劢; 张勇; 范钦颖; 王琳

    2013-01-01

    To compare the side effect of separately injection of inactivated polio vaccine(IPV), Haemophilus influenzae type B vaccine (Hib)and adsorption of acellular DTP vaccine (DTaP)with DTaP-IPV/Hib combined vaccine and explore the more reasonable and effective inoculation approach.Methods: A total of 600 healthy infants in the hospital were randomly divided into two groups according to the principle of voluntary participation.The Group 1 was immunized with IPV,Hib and DTaP seperately,while the Group 2 was injected DTaP-IPV/Hib combined vaccine.Adverse reactions within 48 hours after injection were followed-up of the two groups.Comparative analysis was carried out on the side effects of manifestation, degree and doses of the two groups.Results: There were no significant differences in side effects of manifestation, degree and doses of the two groups (all P>0.05).Conclusion:The combined vaccine DTaP-IPV/Hib is safe and effective.It simplifies the inoculation procedure and is recommended in vaccination.%目的:比较注射单剂吸附无细胞百白破联合疫苗(DTaP)、脊髓灰质炎灭活疫苗(IPV)及B型流感嗜血杆菌疫苗(Hib)与DTaP-IPV/Hib五联疫苗(简称五联疫苗)接种后的副反应,探求合理有效的疫苗接种方式.方法:在我院免疫接种的600例健康婴幼儿,按照监护人自愿原则分为2组,第1组分次注射DTaP、IPV和Hib,第2组注射五联疫苗,接种48h后随访2组婴幼儿副反应情况,并对2组副反应临床表现、强弱、接种针次与副反应的关系进行比较.结果:不同方式预防接种2组婴幼儿副反应临床表现强弱、接种针次与副反应之间均无显著性差异(均P>0.05).结论:五联疫苗的副反应与常规单剂免疫接种相似,它简化了免疫程序,应推荐接种.

  20. Risk behavior for the Human Immunodeficiency Virus among motel clients Las conductas de riesgo al virus de inmunodeficiencia humana entre usuarios de moteles Comportamentos de risco frente ao vírus da imunodeficiência humana entre frequentadores de motéis

    Directory of Open Access Journals (Sweden)

    Helisamara Mota Guedes

    2012-06-01

    Full Text Available This study aimed to verify risk behavior for infection with the Human Immunodeficiency Virus in people who attended motels. This is a cross-sectional study conducted in two motels in two municipalities in the state of Minas Gerais, Brazil, with a sample of 308 randomly selected individuals, aged between 18 and 60 years. Bivariate (chi-square and t test for independent samples and multivariate (logistic regression statistical tests were performed. A total of 45.8% of the participants reported not having used a condom during the last vaginal sexual intercourse, 48.4% did not use a condom during the last oral sex, while 26.3% reported not having used a condom in the last anal intercourse. Having a steady partner was the strongest predictor of not using condoms. Probable beliefs regarding loyalty involved in a stable relationship may be contributing to the failure to use condoms during intercourse, increasing the risk of HIV infection.Este estudio tuvo como objetivo determinar las conductas de riesgo al virus de inmunodeficiencia humana en personas que asistieron moteles. Estudio transversal realizado en dos moteles en dos municipios de Minas Gerais con una muestra de 308 personas. Bivariado se realizaron pruebas estadísticas (Jue-cuadrado y t para muestras independientes y multivariado (regresión logística. La mayoría (42,5% tenían entre 18 y 25 años y el 45,8% no había utilizado preservativo en sus últimas relaciones sexuales vaginales, 48,4% no usó condón para sexo oral, mientras que 26,3 % reportó no haber utilizado el su última relación anal. Tener una pareja estable fue el mejor predictor para no usarse condones. Llegamos a la conclusión de que la lealtad tiende a estar involucrada en una relación estable puede estar contribuyendo a la no utilización de preservativos en las relaciones, aumentando la vulnerabilidad.Este estudo teve por objetivo verificar comportamentos de risco referentes à infecção pelo vírus da imunodefici

  1. Antibody persistence for up to 5 years after a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) given at 12-15 months of age.

    Science.gov (United States)

    Marshall, Gary S; Blatter, Mark; Marchant, Colin; Aris, Emmanuel; Mesaros, Narcisa; Miller, Jacqueline M

    2013-06-01

    A 4-dose series of recently licensed Haemophilus influenzae type b-meningococcal serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) was immunogenic with a clinically acceptable safety profile in infants, with antibodies persisting in most participants for 1 year following dose 4. This study assessed antibody persistence up to 5 years after vaccination. Participants had received HibMenCY-TT or Hib-TT at 2, 4 and 6 months of age. At age 12-15 months, HibMenCY-TT vaccinees received a fourth HibMenCY-TT dose (HibMenCY x 4 group), whereas those who received Hib-TT received a fourth dose of either Hib-TT (Hib) or HibMenCY-TT (HibMenCY x 1). Blood samples were collected 1 month and 1, 3 and 5 years after the last dose for measurement of antipolyribosylribitol phosphate (the Hib capsular polysaccharide) antibodies and serum bactericidal activity (human complement source) against meningococcal serogroups C and Y. Five years after the fourth dose, the percentages of children with antipolyribosylribitol phosphate ≥0.15 μg/mL in HibMenCY x 4, HibMenCY x 1 and Hib groups were 98.8% (95% confidence interval: 93.5%-100%), 97.3% (85.8%-99.9%) and 92.3% (79.1%-98.4%), respectively. The percentages with human complement serum bactericidal activity ≥1:8 for meningococcal serogroup C were 82.9% (72.5%-90.6%), 73.5% (55.6%-87.1%) and 21.1% (9.6%-37.3%), respectively. The percentages with human complement serum bactericidal activity ≥1:8 for serogroup Y were 69.5% (58.4%-79.2%), 54.3% (36.6%-71.2%) and 18.4% (7.7%-34.3%), respectively. HibMenCY-TT given as a 4-dose series or as a single dose at 12-15 months of age induced immune responses for all 3 antigens that lasted for up to 5 years after vaccination in more than half of recipients.

  2. Impact of Haemophilus influenzae type B (Hib) and viral influenza vaccinations in pregnancy for improving maternal, neonatal and infant health outcomes.

    Science.gov (United States)

    Salam, Rehana A; Das, Jai K; Dojo Soeandy, Chesarahmia; Lassi, Zohra S; Bhutta, Zulfiqar A

    2015-06-09

    Infections during pregnancy confers increased risk of maternal and perinatal morbidity and mortality. However, the case for advocating Haemophilus influenzae type B (Hib) and viral Influenza vaccinations in pregnancy is still debatable. To assess the impact of Hib and viral Influenza vaccinations during pregnancy on maternal, neonatal and infant health outcomes compared to placebo/control. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (29 January 2015) and reference lists of retrieved studies. All randomised controlled clinical trials (including cluster-randomised trials) and quasi-randomised trials evaluating Hib or viral influenza vaccination during pregnancy compared with no vaccination or placebo. Two review authors independently assessed trials for inclusion, risk of bias and extracted data. Data were checked for accuracy. Two trials were included this review. One (involving 213 women and 213 neonates) evaluated the impact of Hib vaccination during pregnancy and the other study (involving 2116 women and 2049 neonates) evaluated the impact of viral influenza vaccination during pregnancy. Overall, the HiB vaccination trial was judged to be at 'high risk of bias' due to inadequate randomisation while the other trial was judged to be at 'low risk of bias'. Hib vaccination during pregnancy versus placeboOne trial involving 213 women and 213 neonates evaluating the impact of Hib vaccination during pregnancy was included under this comparison. The study did not report on any of this review's prespecified primary outcomes (including mortality, respiratory tract infection and sepsis) or secondary outcomes (including adverse events) except preterm delivery. There was no clear difference between the Hib vaccination and placebo control groups in terms of preterm delivery (risk ratio (RR) 1.28, 95% confidence interval (CI) 0.12 to 13.86, one study, 213 participants), fetal distress (RR 1.23, 95% CI 0.67 to 2.26, one study, 213 infants

  3. Food and Drug Administration Approval for Use of Hiberix as a 3-Dose Primary Haemophilus influenzae Type b (Hib) Vaccination Series.

    Science.gov (United States)

    Briere, Elizabeth C

    2016-04-29

    On January 14, 2016, GlaxoSmithKline Biologicals (Research Triangle Park, North Carolina) received approval from the Food and Drug Administration (FDA) to expand use of Hiberix (Haemophilus b Conjugate Vaccine [Tetanus Toxoid Conjugate]) for a 3-dose infant primary vaccination series at ages 2, 4, and 6 months. Hiberix was first licensed in the United States in August 2009 for use as a booster dose in children aged 15 months through 4 years under the Accelerated Approval Regulations, in response to a Haemophilus influenzae type b (Hib) vaccine shortage that lasted from December 2007 to July 2009 (1). Expanding the age indication to include infants provides another vaccine option in addition to other currently licensed monovalent or combination Hib vaccines recommended for the primary vaccination series.* Hiberix contains 10 μg purified capsular polyribosyl ribitolphosphate (PRP) conjugated to 25 μg tetanus toxoid (PRP-T) and is supplied as a single-dose vial of lyophilized vaccine to be reconstituted with saline diluent. For the 3-dose primary series, a single (0.5 mL) dose should be given by intramuscular injection at ages 2, 4, and 6 months; the first dose may be given as early as age 6 weeks. The recommended catch-up schedule for PRP-T vaccines (http://www.cdc.gov/vaccines/schedules/hcp/child-adolescent.html) should be followed. As previously recommended, a single booster dose should be administered to children aged 15 months through 18 months; to facilitate timely booster vaccination, Hiberix can be administered as early as age 12 months, in accordance with Hib vaccination schedules for routine and catch-up immunization (1-3).

  4. An economic evaluation of universal infant vaccination against hepatitis B virus using a combination vaccine (Hib-HepB): a decision analytic approach to cost effectiveness.

    Science.gov (United States)

    Harris, A; Yong, K; Kermode, M

    2001-06-01

    To evaluate the health impact and cost effectiveness of two infant vaccination strategies for protection against hepatitis B virus (HBV) infection in the Australian population. Vaccinating only high-risk infants, assuming 65% compliance, was compared with universal vaccination of infants using a combination Hib-HepB vaccine, with 87.4% compliance. A Markov model simulated the natural history of HBV infection and disease in an Australian birth cohort. The cohort was divided into those at high risk of infection (infants born into high-risk families) and low-risk infants. Clinical and epidemiological data used were obtained from published reports and a survey of clinical experts. The model included the health costs associated with acute and chronic HBV infection, and the sequelae of chronic HBV infection. The model predicted that universal hepatitis B vaccination of an Australian birth cohort (260,000 births) would result in a 77% reduction in cases of HBV infection. The incremental cost per life year gained was $11,862, which is low compared with many other health care interventions. With no discounting of costs or consequences, universal vaccination with the combination vaccine was predicted to save lives and reduce costs. There is no socially accepted threshold value for cost per life year gained to guide decisions about funding Australian health care interventions. Nevertheless, based on these results, universal hepatitis B vaccination of Australian infants using a combination Hib-HepB vaccine would almost certainly be regarded as a worthwhile investment of public funds.

  5. Bells, Motels and Permutation Groups

    CERN Document Server

    McGuire, Gary

    2012-01-01

    This article is about the mathematics of ringing the changes. We describe the mathematics which arises from a real-world activity, that of ringing the changes on bells. We present Rankin's solution of one of the famous old problems in the subject. This article was written in 2003.

  6. Lasting immune memory against hepatitis B following challenge 10-11 years after primary vaccination with either three doses of hexavalent DTPa-HBV-IPV/Hib or monovalent hepatitis B vaccine at 3, 5 and 11-12 months of age.

    Science.gov (United States)

    Avdicova, Mária; Crasta, Priya D; Hardt, Karin; Kovac, Martina

    2015-05-28

    The combined hexavalent diphtheria-tetanus-pertussis-hepatitis B-inactivated poliomyelitis - Haemophilus influenzae type b conjugate vaccine (Infanrix hexa™; DTPa-HBV-IPV/Hib: GlaxoSmithKline Vaccines) induces robust responses to the HBV component when administered at 3, 5 and 11-12 months of age. We assessed long term HBV antibody persistence 10-11 years after primary vaccination in infancy. Antibody persistence and immune memory were assessed post-primary vaccination at 3, 5, 11-12 months with DTPa-HBV-IPV/Hib, or monovalent HBV vaccine (Engerix™ B, GlaxoSmithKline Vaccines) co-administered with DTPa-IPV/Hib (Infanrix™-IPV/Hib, GlaxoSmithKline Vaccines) in 185 children aged 11-12 years. Blood samples were collected before and 1 month after a challenge dose of Engerix™ B (10μg dose). 10-11 years after primary vaccination the percentage of subjects with persisting anti-HBs antibody concentrations ≥10mIU/ml was 48.4% in the DTPa-HBV-IPV/Hib group and 58.4% in the DTPa-IPV/Hib+HBV group. After the HBV challenge dose, the percentage with anti-HBs ≥100mIU/ml increased from 14.7% to 93.6% in the DTPa-HBV-IPV/Hib group and 19.1% to 94.4% in the DTPa-IPV/Hib+HBV group. Anti-HBs GMCs increased by at least 187-fold in each group. An anamnestic response (≥4-fold increase in initially seropositive or anti-HBs concentration ≥10mIU/ml in initially seronegative subjects) was observed in 96.8% and 96.6% of subjects in the DTPa-HBV-IPV/Hib and DTPa-IPV/Hib+HBV groups, respectively. No serious adverse events occurred that were considered related to challenge vaccination. Administration of HBV as part of a combination vaccine or as a monovalent vaccine induced long lasting immune memory against HBV in children primed at 3, 5 and 11 months of age. Antibody persistence and immune memory were similar, suggesting that protection afforded by DTPa-HBV-IPV/Hib and monovalent HBV vaccines, is likely to be of similar duration. The administration of HBV challenge dose 10

  7. 以重组肺炎球菌表面黏附素A 为载体蛋白的流感嗜血杆菌多糖结合疫苗的实验研究%Evaluation of the immunogenicity and efficacy of a Hib polysaccharide-protein conjugate vaccine by using PsaA as carrier protein

    Institute of Scientific and Technical Information of China (English)

    陈泽宇; 郭蓉; 徐江红; 吴娟; 薛红刚; 范小勇

    2014-01-01

    Objective To prepare a conjugate vaccine by linking Haemophilus influenzae type b (Hib)polysaccharide to PsaA protein carrier and evaluate the immunogenicity and efficacy of the conjugate vaccine. Methods A recombinant protein rPsaA,expressed by using the genetic engineering technology, was used as a protein carrier to prepare conjugate vaccine together with Hib polysaccharide. Ten mice at age of 3 weeks were immunized with the conjugate vaccine,while another 10 age-matched mice were immunized with Hib-tetanus toxoid(Hib-TT)vaccine which was produced formerly as a control. The mice treated with equal volume of PBS were set up as the negative control. The IgG antibodies in serum samples against PsaA and Hib polysaccharide were detected in two weeks after the final immunization. A suspension of Pneumococ-cus was injected into the middle ears of mice from experiment and control group. Histopathological analysis was performed to measure the clearance of bacteria in the middle ears and the severity of infection on days 3 and 7 after bacterial challenge. Results The rPsaA protein was prepared by the genetic engineering tech-nology and purified successfully with anion-exchange column. The Hib polysaccharide-PsaA protein conju-gate vaccine was prepared through a series of amide condensation reactions. The detection of IgG antibodies against PsaA protein and Hib polysaccharide in the immunized mice demonstrated that there was no signifi-cant difference with the titer of IgG against Hib polysaccharide between the mice immunized with the Hib-PsaA conjugate vaccine and those immunized with the Hib-TT vaccine. Less Pneumococcus strains were de-tected in the middle ears of mice immunized with the conjugate vaccine than those mice immunized with the Hib-TT vaccine three days after challenge. The mice from control group showed severe inflammation in the middle ears than those from experiment group. The Hib polysaccharide-PsaA protein conjugate vaccine im-proved protection against

  8. Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil Impacto do programa de vacinação contra meningites causadas por Haemophilus influenzae tipo b no Brasil

    Directory of Open Access Journals (Sweden)

    Sybelle de Souza Castro Miranzi

    2007-07-01

    Full Text Available This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE. Impact was evaluated through a time series analysis (1983-2002, using regression forecasting (RF by dividing the time series into two periods: (a historical (1983-1998 and (b validation (1999-2002. Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.A proposta deste trabalho foi avaliar o impacto da vacinação contra Haemophilus influenzae tipo b (HIB no Brasil sobre a morbi-mortalidade e a letalidade das meningites por HIB, a partir de base de dados fornecida pelo Ministério da Saúde e as estimativas populacionais provenientes do Instituto Brasileiro de Geografia e Estatística (IBGE. Para a avaliação do impacto utilizou-se análise de tendência temporal (1983-2002, aplicando-se a técnica RF (regression forecasting, dividindo-se a série em dois períodos: (a período histórico (1983-1998 e (b período de estimação (1999-2002. O impacto da vacinação foi positivo, embora tenha se revelado mais expressivo sobre a morbi-mortalidade que sobre a letalidade.

  9. Lasting immune memory against hepatitis B in children after primary immunization with 4 doses of DTPa-HBV-IPV/Hib in the first and 2nd year of life

    Directory of Open Access Journals (Sweden)

    Van Der Meeren Olivier

    2010-01-01

    Full Text Available Abstract Background Few studies have assessed long term persisting immunity against hepatitis B virus (HBV in children vaccinated during infancy with combined vaccines containing recombinant HBV surface antigen (HBs. We assessed antibody persistence and immune memory in children 4-5 years of age, previously vaccinated with four doses of combined hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix hexa™. Methods Immune memory was assessed in 301 children through administration of a challenge dose of monovalent HBV vaccine. Results At 4-5 years of age, 85.3% of subjects had persisting anti-HBs antibody concentrations ≥ 10 mIU/mL, rising to 98.6% after the HBV challenge dose. All but 12 subjects (95.8% achieved post-challenge anti-HBs concentrations ≥ 100 mIU/mL. The post-challenge anti-HBs GMC rose by 100-fold compared to pre-challenge concentrations. An anamnestic response to the HBV vaccine challenge was observed in 96.8% of subjects, including 17/21 (81.0% of children with initially undetectable antibodies ( Conclusion The combined DTPa-HBV-IPV/Hib vaccine induced lasting immune memory against hepatitis B. Long term protection afforded by DTPa-HBV-IPV/Hib is likely to be similar to that observed following priming with monovalent HBV vaccines. Trial registration http://www.clinicaltrials.gov 106789 NCT00411697

  10. DTaP-IPV-Hep B-Hib vaccine (Hexaxim®) : a review of its use in primary and booster vaccination.

    Science.gov (United States)

    McCormack, Paul L

    2013-02-01

    Hexaxim(®) (DTaP-IPV-Hep B-Hib) is a new, thiomersal-free, fully liquid, hexavalent combination pediatric vaccine containing diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, recombinant hepatitis B virus surface antigen produced in the yeast Hansenula polymorpha, and Haemophilus influenzae type b polysaccharide (polyribosylribitol phosphate) conjugated to tetanus toxoid. It is currently registered in markets outside of the EU for primary vaccination of infants from 6 weeks of age and for booster vaccination up to 24 months of age. In randomized controlled trials, primary vaccination of infants with Hexaxim(®) using various immunization schedules was highly immunogenic for all vaccine component antigens regardless of the administration schedule, producing high levels of seroprotection or seroconversion for each antigen. Hexaxim(®) was as immunogenic as the comparator DTwP- or DTaP-based vaccines in these studies. The serological responses were generally sustained at high levels over a follow-up of ≈1 year, and booster vaccination at 15-18 months further enhanced the immune response. Hexaxim(®) was less reactogenic than a DTwP-based combination vaccine, and displayed a tolerability profile similar to those of the comparator DTaP-based combination vaccines. Thus, Hexaxim(®) provides effective seroprotection or seroconversion against six major childhood diseases simultaneously, both as primary and booster vaccination, and offers the benefits and convenience of a fully liquid, ready-to-use vaccine.

  11. Synergism between cAMP and PPARγ Signalling in the Initiation of UCP1 Gene Expression in HIB1B Brown Adipocytes

    Directory of Open Access Journals (Sweden)

    H. Y. Chen

    2013-01-01

    Full Text Available Expression of the brown adipocyte-specific gene, uncoupling protein 1 (UCP1, is increased by both PPARγ stimulation and cAMP activation through their ability to stimulate the expression of the PPAR coactivator PGC1α. In HIB1B brown preadipocytes, combination of the PPARγ agonist, rosiglitazone, and the cAMP stimulator forskolin synergistically increased UCP1 mRNA expression, but PGC1α expression was only increased additively by the two drugs. The PPARγ antagonist, GW9662, and the PKA inhibitor, H89, both inhibited UCP1 expression stimulated by rosiglitazone and forskolin but PGC1α expression was not altered to the same extent. Reporter studies demonstrated that combined rosiglitazone and forskolin synergistically activated transcription from a full length 3.1 kbp UCP1 luciferase promoter construct, but the response was only additive and much reduced when a minimal 260 bp proximal UCP1 promoter was examined. Rosiglitazone and forskolin in combination were able to synergistically stimulate promoters comprising of tandem repeats of either PPREs or CREs. We conclude that rosiglitazone and forskolin act together to synergistically activate the UCP1 promoter directly rather than by increasing PGC1α expression and by a mechanism involving cross-talk between the signalling systems regulating the CRE and PPRE on the promoters.

  12. Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines.

    Science.gov (United States)

    Paulke-Korinek, Maria; Fischmeister, Gustav; Grac, Ana; Rendi-Wagner, Pamela; Kundi, Michael; Mohsenzadeh-Rabbani, Afsaneh; Moritz, Katharina; Fenninger, Beate; Jarisch, Reinhart; Jasinska, Joanna; Holzmann, Heidemarie; Wiedermann, Ursula; Kollaritsch, Herwig

    2011-07-18

    To determine the proficiency of the Austrian childhood vaccination schedule to induce long lasting seroprotection against vaccine preventable diseases a seroepidemiological study in 348 children between four and eight years of age was conducted. Antibodies against diphtheria, tetanus, pertussis, hepatitis B, measles, mumps and rubella antigens were assessed in children, who had been vaccinated with hexavalent DTaP-HBV-IPV/Hib vaccines at three, four, five months and in the second year of life and/or MMR vaccines in the second year of life at least once, but mostly twice. High seroprotection rates (SPRs) were detected for tetanus (96%) and measles (90%). SPRs regarding diphtheria and mumps were 81% and 72%, respectively. Rubella-SPRs were 68% in females and 58% in males. Hepatitis B-antibody levels ≥10 mIU/mL were present in 52%; antibodies against pertussis were detected in 27% of the children. SPRs for measles and rubella depended on the interval since last vaccination; mumps-antibodies were significantly lower after one MMR-vaccination only. Antibodies against diphtheria, tetanus and pertussis depended on the interval since last vaccination while HBs-antibodies did not. The low levels of antibodies 1-7 years after vaccination against pertussis, rubella and mumps after only one vaccination should be considered when recommending new vaccination schedules.

  13. DTaP-IPV/Hib五联疫苗与单苗接种不良反应对比分析%Comparative Analysis of the Adverse Reaction of DTaP-IPV/Hib with Single Inoculation of the Combined Vaccine

    Institute of Scientific and Technical Information of China (English)

    李娟

    2014-01-01

    Objective To compare single agent adsorption cellfree the DPT combined vaccine (DTaP) environments according, polio inactivated vaccine (IPV) and haemophilus influenzae type B (Hib) and DTaP vaccine-IPV/Hib immovable) (hereinafter referred to as immovable vaccine immunization vaccine adverse reactions, to explore a more reasonable immune process. Methods 378 healthy infants and young children in the hospital of vaccination, in accordance with the principle of voluntary guardian divided into 2 groups, group A immovable vaccine, group B DTaP and Hib vaccine and IPV, 48 h after fol ow-up of 2 groups of infants and young children adverse reactions, and the adverse reaction of two groups were analyzed.Results In A group, B injection site redness incidence rates were 16.5%, 10%. Systemic adverse reactions were mainly fever, abnormal crying, lethargy, irritability, loss of appetite, A, B group the incidence of considerable. Conclusion The immovable vaccine adverse reactions similar to conventional single dose of immunization, it simplifies the immunization program, should be recommended.%目的比较接种单剂吸附无细胞百白破联合疫苗(DTaP)、脊髓灰质炎灭活疫苗(IPV)及B型流感嗜血杆菌疫苗(Hib)与DTaP-IPV/Hib五联疫苗(简称五联疫苗)接种后的不良反应,探求更合理的免疫程序。方法在我院免疫接种的378例健康婴幼儿,按照监护人自愿原则分为两组,A组接种五联疫苗,B组接种DTaP、Hib结合疫苗和IPV,48 h后随访两组婴幼儿不良反应情况,并对两组不良反应进行对比分析。结果 A、B组注射部位红肿的发生率分别为16.5%、10.0%。全身不良反应主要表现为发热、异常哭闹、嗜睡、易激惹、食欲下降,A、B组的发生率相当。结论五联疫苗的不良反应与常规单剂免疫接种相似,它简化了免疫程序,应推荐接种。

  14. Standard and Protocol Technical guideline for the practice of DTaP-IPV/Hib combination vaccine%吸附无细胞百白破、灭活脊髓灰质炎和b型流感嗜血杆菌(结合)联合疫苗(DTaP-IPV/Hib五联疫苗)应用技术指南

    Institute of Scientific and Technical Information of China (English)

    中华预防医学会

    2011-01-01

    @@ 百日咳、白喉、破伤风、脊髓灰质炎(脊灰)、b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)引起的感染性疾病是常见的严重危害人类健康,特别是儿童健康的传染病.

  15. Lasting immune memory against hepatitis B in 12-13-year-old adolescents previously vaccinated with 4 doses of hexavalent DTPa-HBV-IPV/Hib vaccine in infancy.

    Science.gov (United States)

    Behre, Ulrich; Van Der Meeren, Olivier; Crasta, Priya; Hanssens, Linda; Mesaros, Narcisa

    2016-11-01

    Vaccinating infants against hepatitis B virus (HBV) is the most effective way of preventing the disease. However, since HBV exposure can increase during adolescence, it is essential that antibody persistence is maintained. We evaluated the antibody persistence and immune memory against hepatitis B, in 12-13 y olds who had received complete primary + booster vaccination with diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus/Haemophilus influenza type b (DTPa-HBV-IPV/Hib) vaccine in infancy. Open phase-IV study conducted at 12 centers in Germany [NCT02052661]. Adolescents aged 12-13 y, vaccinated with 4 doses of DTPa-HBV-IPV/Hib (Infanrix hexa™, GSK Vaccines) in infancy, received a single challenge dose of monovalent pediatric hepatitis B vaccine (Engerix™-B Kinder; GSK Vaccines). Blood samples were taken before and 1-month post-challenge to measure anti-hepatitis B (anti-HBs) antibodies using a chemiluminescence immunoassay (seroprotection cut-off: ≥10 mIU/ml). Post-challenge adverse events (AEs) were monitored. 300 subjects were vaccinated; of 293 subjects in the ATP immunogenicity cohort, 60.5% had pre-challenge anti-HBs antibodies ≥10 mIU/ml, which rose to 97.6% post-challenge (≥100 mIU/ml in 94.1%). An anamnestic response was seen in 96.5% subjects. A 150-fold increase in antibody geometric mean concentrations was observed (22.4 to 3502.6 mIU/ml). Pain (44%) and fatigue (24.3%) were the most frequent solicited local and general AEs, respectively; 14.7% subjects reported unsolicited symptoms during the 31-day post-vaccination period. Two vaccine-unrelated serious AEs occurred. Vaccination with DTPa-HBV-IPV/Hib in infancy induces sustained seroprotection and immune memory against HBV, as shown by the strong anamnestic response to the hepatitis B vaccine challenge in 12-13 year-old adolescents.

  16. Immune memory to hepatitis B persists in children aged 7-8 years, who were vaccinated in infancy with 4 doses of hexavalent DTPa-HBV-IPV/Hib (Infanrix™ hexa) vaccine.

    Science.gov (United States)

    Van Der Meeren, Olivier; Bleckmann, Gerhard; Crasta, Priya D

    2014-01-01

    Protection against hepatitis B disease relies on either protective serum antibodies or on the ability of the immune system to mount an anamnestic response when confronted with the hepatitis B virus (HBV). This open multicenter study (EUDRACT: 2010-022538-10) measured antibodies to HBV surface antigen (anti-HBs) in 7-8-year-old children who had received 4 doses of hexavalent diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Hemophilus influenzae type b conjugate vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa; GlaxoSmithKline Vaccines) in the first 2 years of life through routine vaccine services in Germany. The ability of these children to mount an anamnestic response to a challenge dose of monovalent HBV vaccine (Engerix™ B Kinder; GlaxoSmithKline Vaccines) was also assessed. Before the challenge dose, 78.5% of children had anti-HBs levels ≥6.2 mIU/mL (seropositive) and 72.2% had anti-HBs levels ≥10 mIU/mL (seroprotected). Post-challenge, 98.9% had anti-HBs levels ≥10 mIU/mL and 95.8% had anti-HBs ≥100 mIU/mL. An anamnestic response to the challenge was observed in 96.6% of all subjects. The challenge dose was well tolerated, with a reactogenicity and safety profile consistent with published data. DTPa-HBV-IPV/Hib induces long-lasting immune memory to HBV that appears very similar to that induced by monovalent HBV vaccines. Protection against hepatitis B may be conferred through immune memory in subjects who responded to primary vaccination, even when they subsequently lose detectable levels of circulating anti-HBs antibodies.

  17. Motel Hilton, (U.S.A.

    Directory of Open Access Journals (Sweden)

    Skidmore, Owings & Merrill, Arquitectos Ingenieros

    1966-05-01

    Full Text Available This hotel system includes four buildings, each two storeys high, with a total of 150 guest rooms, and a central nucleus, where the reception rooms, offices, dorman's house, 2 restaurants, a cafeteria, a beauty saloon, hairdresser's shop and other facilities are located. Both the external and internal architectural pattern and style aim at providing a highly intimate atmosphere to visitors. The distribution has been most carefully thought out, to ensure maximum functional efficiency.Consta este conjunto hotelero de: 4 edificios, de dos plantas de altura cada uno, con un total de 150 habitaciones para huéspedes; y de una edificación central, que contiene las zonas de: recepción, conserjería, oficinas de la administración, 2 restaurantes, cafetería, salón de belleza, peluquería, etc. Tanto la composición estética del exterior como la del interior, imprimen una gran sensación de intimidad a usuarios y visitantes. La organización en planta ha sido estudiada con sumo cuidado, a fin de obtener un funcionamiento perfecto del conjunto.

  18. Heaven and Hell at the Paradise Motel

    Directory of Open Access Journals (Sweden)

    Tessa Chudy

    2013-10-01

    Full Text Available This piece is taken from the novel “Heaven and Hell at the Paradise Motel” and the exegesis that together forms my PhD thesis. The three main strands of this thesis are Gothic, Noir and sense of place. The novel, ‘‘Heaven and Hell at the Paradise Motel”, is preoccupied with the natural environment, its subtle seasonal changes and the way the environment impacts on its human inhabitants and how they in turn affect it. The novel is, in a very Gothic sense, haunted by dreams, apparitions and narratives – specifically mini-narratives that reflect the nature of fairy tales, horror stories and urban myths. It contains elements of melodrama, horror, romance. The story follows a deeply dysfunctional family through a seasonal cycle: beginning in Spring and ending once again in Spring. A key focus for both the creative and the theoretical work was the everyday application of the Gothic and Noir – for example a house doesn’t have to be a castle to be haunted; people don’t have to be monsters to be monstrous. The dark, the strange, the sinister and the perverse lurk in the shadows of everyday reality, but also how these elements intertwined within the landscape.

  19. Bacterial aetiology of otitis media in children in Pakistan aged 0-59 months; laboratory surveillance data from 2004 to 2013: comparison between before and after the introduction of Hib vaccination.

    Science.gov (United States)

    Shakoor, Sadia; Malik, Faisal Riaz; Khan, Erum

    2016-02-01

    Otitis media (OM) is a leading cause of childhood illness. In Pakistan, the estimated incidence of OM-associated hearing impairment is >40/10,000 population and OM-associated mortality is 50-79·9/10×10(6) population. No OM microbiology data are available from Pakistan since 2004. To describe the microbiology of OM in children aged 0-59 months in Pakistan. Laboratory data on ear pus specimens taken from children seen between 2004 and 2013 were retrieved from the Laboratory Information Systems of the Aga Khan University and entered into Microsoft Excel and SPSS version 16.0. Bacterial culture results from 277 specimens were analysed. Staphylococcus aureus and Pseudomonas aeruginosa were the organisms most commonly isolated, followed by Streptococcus pneumoniae and Haemophilus influenzae. Polymicrobial cultures significantly increased in the post-Hib vaccination period from 19·5% to 32·7% (P = 0·038). H. influenzae also increased significantly from 16·8% to 24·5% (P = 0·038). An increase in H. influenzae may reflect non-b capsular types (not determined in the study), or even capsular types from areas with low vaccine coverage. Increases in polymicrobial cultures and H. influenzae warrant further study.

  20. Cromatografía de adsorción para purificar el disacárido espaciador del ingrediente farmacéutico activo de la vacuna QuimiHib®

    Directory of Open Access Journals (Sweden)

    Belinda Díaz,

    2013-04-01

    Full Text Available En este trabajo se estudiaron las condiciones de la cromatografía de adsorción en Silicagel 60 para la purificación del disacárido espaciador (DSE, componente del ingrediente farmacéutico activo de la vacuna QuimiHib®. Para ello se realizó un desescalado a una escala analítica que representó el 1,8% del proceso industrial. Se logró reproducibilidad en términos de calidad de empaque, pureza y recobrado entre ambas escalas. Se determinó que la capacidad dinámica de carga de la resina Silicagel 60 por el DSE fuera de aproximadamente 125±0,2 mg/mL de resina empacada; 3,4 veces superior al proceso base. El perfil de elución que se obtuvo indicó la posibilidad de colectar una fracción única en el rango 195±2 y 260±2 min. Si se mantiene un correcto empaque de la resina cromatográfica, determinado por un factor de asimetría entre 0,8 y 1,2 se garantiza un recobrado de 58,9±4,5% y una pureza equivalente a la del patrón de referencia en el análisis por cromatografía de capa delgada. El ajuste de la condición de adsorción incrementa la productividad de la operación en 3,5 veces, indicando que la propuesta es económicamente factible.

  1. Children who received PCV-10 vaccine from a two-dose vial without preservative are not more likely to develop injection site abscess compared with those who received pentavalent (DPT-HepB-Hib vaccine: a longitudinal multi-site study.

    Directory of Open Access Journals (Sweden)

    Yemane Berhane

    Full Text Available BACKGROUND: The single dose pneumonia ten-valent vaccine has been widely used and is highly efficacious against selected strains Streptococcus pneumonia. A two-dose vial without preservative is being introduced in developing countries to reduce the cost of the vaccine. In routine settings improper immunization practice could result in microbial contamination leading to adverse events following immunization. OBJECTIVE: To monitor adverse events following immunization recommended for routine administration during infancy by comparing the rate of injection-site abscess between children who received PCV-10 vaccine and children who received the Pentavalent (DPT-HepB-Hib vaccine. METHODS: A longitudinal population-based multi-site observational study was conducted between September 2011 and October 2012. The study was conducted in four existing Health and Demographic Surveillance sites run by public universities of Abraminch, Haramaya, Gondar and Mekelle. Adverse events following Immunization were monitored by trained data collectors. Children were identified at the time of vaccination and followed at home at 48 hour and 7 day following immunization. Incidence of abscess and relative risk with the corresponding 95% Confidence Intervals were calculated to examine the risk difference in the comparison groups. RESULTS: A total of 55, 268 PCV and 37, 480 Pentavalent (DPT-HepB-Hib vaccinations were observed. A total of 19 adverse events following immunization, 10 abscesses and 9 deaths, were observed during the one year study period. The risk of developing abscess was not statistically different between children who received PCV-10 vaccine and those received Pentavalent (RR = 2.7, 95% CI 0.576-12.770, and between children who received the first aliquot of PCV and those received the second aliquot of PCV (RR = 1.72, 95% CI 0.485-6.091. CONCLUSION: No significant increase in the risk of injection site abscess was observed between the injection sites of PCV

  2. 桃源居社区儿童b型流感嗜血杆菌结合疫苗副反应观察%The Side Effects of Haemophilus Influenzae Type B(Hib)Vaccine Inoculation of Children in Taoyuanju Community

    Institute of Scientific and Technical Information of China (English)

    徐彩文; 曾艳红; 赵鹏; 徐志浩; 叶慧琼

    2011-01-01

    本实验旨在观察深圳市桃源居社区儿童接种b型流感嗜血杆菌(Hib)结合疫苗后副反应情况.通过系统跟进观察398名儿童接种后情况,设置梯度进行分类,与其他参考文献及厂商资料进行比较后得出,Hib疫苗在现场接种中副反应发生率和强度低,局部反应轻微,是一种安全有效的疫苗,可以在社区儿童中广泛推广使用.

  3. Expert Appeal: Put Hib Vaccine in Routine Childhood Immunization Schedules%关注三亿中国儿童的Hib感染问题——专家呼吁将Hib疫苗纳入儿童计划免疫

    Institute of Scientific and Technical Information of China (English)

    房玉新; 贺芳

    2005-01-01

    关注儿童Hib感染 2004年gs ,亚洲太平洋儿科学会存马来西亚吉隆坡召开了第二届“疫苗学2004:Hib在亚洲”专题研讨会.会议的中心议题就是“Hib疾病与疫苗在亚洲的推广”。杨永弘教授介绍,b型流感嗜血杆菌(Haemophilus influenzae b,Hib)属下革兰阴性杆菌,主要累及5岁以下婴幼儿,是引起儿童肺炎和脑膜炎的重要元凶。

  4. Moduli Spaces of Abelian Vortices on Kahler Manifolds

    CERN Document Server

    Baptista, J M

    2012-01-01

    We consider the self-dual vortex equations on a positive line bundle L --> M over a compact Kaehler manifold of arbitrary dimension. When M is simply connected, the moduli space of vortex solutions is a projective space. When M is an abelian variety, the moduli space is the projectivization of the Fourier-Mukai transform of L. We extend this description of the moduli space to general abelian GLSM, i.e. to vortex equations with a torus gauge group acting linearly on a complex vector space. In this case the vortex moduli space becomes a toric orbifold and a toric fibration over a cartesian product of Pic^0(M)'s, respectively. In all these examples we compute the Kaehler class of the natural L^2-metric on the moduli space. In the simplest examples we compute the volume and total scalar curvature of the muduli space. Finally, in the case of abelian GLSM, we note that the vortex moduli space is a compactification of the space of holomorphic maps from M to toric targets, just as in the usual case of M being a Riema...

  5. Random Riesz energies on compact K\\"{a}hler manifolds

    CERN Document Server

    Feng, Renjie

    2011-01-01

    This article determines the asymptotics of the expected Riesz s-energy of the zero set of a Gaussian random systems of polynomials of degree N as the degree N tends to infinity in all dimensions and codimensions. The asymptotics are proved more generally for sections of any positive line bundle over any compact Kaehler manifold. In comparison with the results on energies of zero sets in one complex dimension due to Qi Zhong (arXiv:0705.2000) (see also [arXiv:0705.2000]), the zero sets have higher energies than randomly chosen points in dimensions > 2 due to clumping of zeros.

  6. The Batalin-Vilkovisky formalism on fermionic Kahler manifolds

    NARCIS (Netherlands)

    Aoyama, S.; Vandoren, S.

    2007-01-01

    We show that the K¨ahler structure can be naturally incorporated in the Batalin-Vilkovisky formalism. The phase space of the BV formalism becomes a fermionic K¨ahler manifold. By introducing an isometry we explicitly construct the fermionic irreducible hermitian symmetric space. We then give some so

  7. 生田斗真 Special Seaside Motel

    Institute of Scientific and Technical Information of China (English)

    王睿悦

    2010-01-01

    刚被《人间失格》所吸引的我们,又能看到生田斗真的新电影作品了。《海边汽车旅馆》.今夏即将上映《花水木》.夏天变成了生田斗真个人的电影节。他的魅力绝不亚于任何一间美丽的海景套房,给人以无限的憧憬。

  8. Vanameelne mähib ennast riigilippu / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2008-01-01

    George Clooney mängufilm "Head õhtut ja õnn kaasa" ("Good Night, and Good Luck") teleajakirjanik Edward R. Murrow võitlusest senaator Joseph McCarthy vastu (Ameerika Ühendriigid 2005). Lühiandmed George Clooney kohta

  9. Vanameelne mähib ennast riigilippu / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2008-01-01

    George Clooney mängufilm "Head õhtut ja õnn kaasa" ("Good Night, and Good Luck") teleajakirjanik Edward R. Murrow võitlusest senaator Joseph McCarthy vastu (Ameerika Ühendriigid 2005). Lühiandmed George Clooney kohta

  10. Haemophilus Influenzae Type B (Hib): Questions and Answers

    Science.gov (United States)

    ... continued) page 3 of 3 Who recommends this vaccine? The Centers for Disease Control and Prevention (CDC), the American Academy of Pediatrics (AAP), and the American Academy of Family Physicians ( ...

  11. Visa rühib visalt Sinu rahakotti / Silvia Viidik

    Index Scriptorium Estoniae

    Viidik, Silvia, 1972-

    2009-01-01

    Maailma suurima maksete vahendaja Visa 2009. aasta kolmanda kvartali tulemustest; samas on Visa sõlminud ka sponsorlepingu Rahvusvahelise Olümpiakomiteega, mis võimaldab krediitpangandushiiul saada reklaamiaega üle kogu maailma ning suurendada krediitkaartide kasutajate arvu veelgi

  12. Dirac-Kahler equation in curved space-time, relation between spinor and tensor formulations

    CERN Document Server

    Red'kov, V M

    2011-01-01

    A common view is that generalization of a wave equation on Riemannian space-time is substantially determined by what a particle is - boson or fermion. As a rule, they say that tensor equations for bosons are extended in a simpler way then spinor equations for fermions. In that context, a very interesting problem is of extension a wave equation for Dirac--K\\"{a}hler field (Ivanenko--Landau field was historically first term, also the term a vector field of general type was used). The article relates a generally covariant tensor formalism to a spinor one when these both are applied to description of the Dirac-K\\"ahler field in a Rimannian space-time. Both methods are taken to be equivalent and the tensor equations are derived from spinor ones. It is shown that, for characterization of Dirac-K\\"ahler's tensor components, two alternative approaches are suitable: these are whether a tetrad-based pseudo tensor classification or a generally coordinate pseudo tensor one. By imposing definite restrictions on the the Di...

  13. CHANGES IN SOME BIOCHEMICAL PARAMETERS IN PATIENTS WITH KAHLER RUSTITZKI DISEASE

    Directory of Open Access Journals (Sweden)

    Mihai Bularda Morozan

    2010-09-01

    Full Text Available This paper aims to carry out research into the changes in some biochemical parameters in 10 patients diagnosed with plasmacytoma. The parameters have been obtained in the laboratory of “Elena Beldiman” Emergency Hospital Barlad, and in the”Dr Stoian –Dr. Ungureanu”Private Medical Practice, between 2005 – 2011. The analyses results, which are in accordance with those from the scholarly literature, show that the changes in blood indicators may occur as a result of the influence of various factors which negatively modify the patient’s health. The 10 cases surveyed during 2010 also emphasize the frequency of this disease in the sense that they have the tendency of equalization under the aspect of the two genders ( masculin and feminin in comparision with the years before 2010

  14. Complete Calabi-Yau metrics from Kahler metrics in D=4

    CERN Document Server

    Leston, Mauricio

    2010-01-01

    In [20]-[22] there was developed a method for constructing a class of Calabi-Yau metrics in D=6 with a hamiltonian isometry, which require a 4-dimensional hyperkahler structure as initial input. Particular solutions of the resulting non linear equation corresponding to complete Calabi-Yau metrics were found in [22], but surprisingly the equation gets harder to solve for general hyperkahler structures due to the non trivial curvature of the Ricci flat 4-metric. In the present letter we suggest that the complications due to the choice of the hyperkahler structure may be avoided. We carefully analyze the assumptions made in those references and we work out a construction which do not require such initial input. This is also generalized to higher dimensions. It should be emphasized that there is nothing wrong with the use of hyperkahler structures as a solution generating technique, what is pointed out here is that this method is just optional.

  15. Suzhou Jiafu Relay Station Motel%苏州嘉福驿站汽车旅馆

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ 本案为国内第一家创新理念的设计模式,提供给开车族人清静、舒适、隐密、精致、安全、专属自己的空间天地. 1.室外广场水景加同步变色LED.配套网球场.旅馆有两个入口,一个是经过岗亭订房的汽车入口,一个是进入大堂总台订房.改造后建筑外观采用后现代主义风格,以简约的清水混凝土打造出平实浑厚的沉稳意象,雨棚造型独特,采用水泥板和彩色亚克力结合,使整个建筑浑然一体.

  16. AIR CONDITIONING SYSTEMS FOR HOTELS AND MOTELS%旅馆空调系统

    Institute of Scientific and Technical Information of China (English)

    董天禄

    2001-01-01

    本文介绍当代国外旅馆空调系统的设计标准和负荷特点,指出保持旅馆客房合适的空气品质和低的湿度是很重要的一项技术要求.文中还具体介绍了适用于旅馆的包括新风机组的各种空调系统和设备.

  17. Solar hot water system installed at Days Inn Motel, Dallas, Texas (Forrest Lane)

    Science.gov (United States)

    1980-09-01

    The solar system was designed to provide 65 percent of the total Domestic Hot Water (DHW) demand. The liquid flat plate (water) collector (1,000 square feet) system automatically drains into the 1,000 gallon steel storage tank located in the mechanical room when the pump is not running. Heat is transferred from the storage tank to DHW tanks through a tube and shell heat exchanger. A circulating pump between the DHW tanks and the heat exchanger enables solar heated water to help make DHW tank standby losses. All pumps are controlled by differential temperature.

  18. 莫泰168 赢在错位%Motel: Wins by The Adjustment of Positions

    Institute of Scientific and Technical Information of China (English)

    昝慧昉

    2006-01-01

    为了与同行形成差异,莫泰更侧重于树立商务型经济酒店的定位。“我们不能简单的跟着他们跑,否则就会永远跟在他们后面。所以我们的定位要此他们定的微高一点,实际上就是去争夺三星级和四星级之间的客源。”

  19. Solar hot water system installed at Day's Inn Motel, Dallas, Texas (Valley View)

    Science.gov (United States)

    1980-09-01

    The solar system was designed to provide 65 percent of the total domestic hot water (DHW) demand. A liquid (water) flat plate collector (1,000 square feet) system automatically drains into the 1,000 gallon steel storage tank when the solar pump is not running. Heat is transferred from the DHW tanks through a shell and tube heat exchanger. A circulating pump between the DHW tanks and heat exchanger enables solar heated water to help make up standby losses. All pumps are controlled by differential temperature controllers.

  20. Solar hot water system installed at Day's Inn Motel, Savannah, Georgia

    Science.gov (United States)

    1980-09-01

    The Solar System was designed to provide 50 percent of the total Domestic Hot Water (DHW) demand. Liquid Flat Plate Collectors (900 square feet) are used for the collector subsystem. The collector subsystem is closed loop, using 50 percent Ethylene Glycol solution antifreeze for freeze protection. The 1,000 gallon fiber glass storage tank contains two heat exchangers. One of the heat exchangers heats the storage tank with the collector solar energy. The other heat exchanger preheats the cold supply water as it passes through on the way to the Domestic Hot Water (DHW) tank heaters. Electrical energy supplements the solar energy for the DHW. The Collector Mounting System utilizes guy wires to structurally tie the collector array to the building.

  1. Solar hot water system installed at Days Inn Motel, Jacksonville, Florida

    Science.gov (United States)

    1980-09-01

    The solar system was designed to provide 65 percent of the hot water demand. Water in the liquid flat plate collector (900 square feet) system automatically drains into the 1000 gallon lined and vented steel storage tank when the pump is not running. Heat is transferred from storage to Domestic Hot Water (DHW) tanks through a tube and shell heat exchanger. A circulating pump between the DHW tanks and heat exchanger enables solar heated water to help make up DHW standby losses. All pumps are controlled by differential temperature.

  2. The Visual Co-textualization of Spatio-Joual in the Motel Galactic Series

    OpenAIRE

    Pylyser, Charlotte; Tremblay-Gaudette, Gabriel

    2016-01-01

    In this article the authors question whether the co-presence of words and pictures specific to the comics medium creates possibilities for the comprehension of regional languages and dialects abroad. They propose to call this phenomenon "visual co-textualization" rather than visual contextualization after the difference which contemporary linguistics makes between the extra-textual environment of a given utterance (context) and its textual or visual surroundings (co-text). They examine in wha...

  3. REDUCTIONS WITHOUT REGRET: DETAILS - AVOIDING BOX CANYONS, ROACH MOTELS, AND WRONG TURNS

    Energy Technology Data Exchange (ETDEWEB)

    Swegle, John A.; Tincher, Douglas J.

    2013-08-09

    The United States is concurrently pursuing the goals of reducing the size of its nuclear weapons force – strategic and non-strategic, deployed and non-deployed – and of modernizing the weapons it continues to possess. Many of the existing systems were deployed 30 to 50 years ago, and the modernization process can be expected to extend over the next decade or more. Given the impossibility of predicting the future over the lifetime of systems that could extend to the end of this century, it is essential that dead ends in force development be avoided, and the flexibility and availability of options be retained that allow for • Scalability downward in the event that further reductions are agreed upon; • Reposturing to respond to changes in threat levels and to new nuclear actors; and • Breakout response in the event that a competitor significantly increases its force size or force capability, In this paper, we examine the current motivations for reductions and modernization; review a number of historical systems and the attendant capabilities that have been eliminated in recent decades; discuss the current path forward for the U.S. nuclear force; provide a view of the evolving deterrence situation and our assessment of the uncertainties involved; and present examples of possibly problematic directions in force development. We close with our thoughts on how to maintain flexibility and the availability of options for which a need might recur in the future.

  4. Development of desiccant based air conditioning for hotels and motels. Final report, phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Banks, N.J.

    1994-10-01

    This report contains final reports from two phases of field tests: Phase I at the Marriott Courtyard in West Palm Beach, completed in October 1991, and Phase II at the Walt Disney World Swan Hotel in Orlando, completed in August 1993. The goal was to measure the performance and reliability of the desiccant units. The successfull program proved the value of the gas-fired desiccant technology to the hospitality industry. The desiccant units reduced moisture by 15 to 20% relative humidity. Measurements of temperature, humidity, and wallboard moisture content showed a dramatic reduction in the humidity levels experienced prior to installation of the units and in the control areas without desiccants. Moisture damage was kept in check and remodelling due to it was eliminated.

  5. Kosovo rühib diplomaatide toel iseseisvuse suunas / Martin Jaigma

    Index Scriptorium Estoniae

    Jaigma, Martin

    2006-01-01

    Kuigi Serbia on kritiseerinud Kosovo võimaliku iseseisvumise kõneluste peavahendajat, ÜRO eriesindajat Martti Ahtisaarit provintsi huvide esindamises, alustasid Serbia ja Kosovo poliitikud 20. veebruaril läbirääkimisi Kosovo staatuse üle

  6. ASEAN rühib mööda USAst ja Euroopast

    Index Scriptorium Estoniae

    2004-01-01

    Vientianis toimunud ASEAN-i ja Hiina tippkohtumisel kirjutati alla ASEAN-i ja Hiina koostööleppele, mille siht on kõikide nendevaheliste tollipiiride kaotamine aastaks 2010. ASEAN-i ja USA ning ASEAN-i ja Euroopa vahelise kaubanduse mahust

  7. Eesti algatatud maksurevolutsioon pühib üle maailma / Daniel J. Mitchell

    Index Scriptorium Estoniae

    Mitchell, Daniel J.

    2005-01-01

    Heritage Fondi analüütik hindab Eesti osa teiste riikide maksupoliitika mõjutajana, samas leiab ta, et maksurevolutsioon on olnud nii edukas ja maksukonkurents nii suur, et selle käimalükkaja - Eesti - alandab oma maksumäära, et teistega sammu pidada

  8. Tallinna Sadam rühib Läänemere edukaimaks / Taivo Paju

    Index Scriptorium Estoniae

    Paju, Taivo, 1968-

    2000-01-01

    AS Tallinna Sadam meelitab Muugale maailma võimsaima merekonteinerite firma Hutchinson, et haarata lisaks Vene naftale ka tükk Ida-Lääne vahelisest konteinerkaubandusest. Diagramm: sadamate osakaal kogu veosekäibest

  9. Tants pühib linnaruumilt ajalootolmu / Madli Teller ; intervjueerinud Evelin Lagle

    Index Scriptorium Estoniae

    Teller, Madli

    2010-01-01

    2011. aasta Euroopa kultuuripealinna programmi raames eesti ja soome noorte tantsukunstnike koostööprojektist "Old Spaces Living Art" ("Eakade paikade elav kunst"), kus ühendatakse nüüdistants ja Tallinna ajalooline linnaruum

  10. Tants pühib linnaruumilt ajalootolmu / Madli Teller ; intervjueerinud Evelin Lagle

    Index Scriptorium Estoniae

    Teller, Madli

    2010-01-01

    2011. aasta Euroopa kultuuripealinna programmi raames eesti ja soome noorte tantsukunstnike koostööprojektist "Old Spaces Living Art" ("Eakade paikade elav kunst"), kus ühendatakse nüüdistants ja Tallinna ajalooline linnaruum

  11. Briti peaminister Tony Blair rühib ajaloolisele kolmandale võidule / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2005-01-01

    Suurbritannias algas parlamendivalimiste kampaania. Arvamusküsitluste kohaselt on Tony Blairil võimalus võita esimese leiboristist peaministrina kolmandad järjestikused valimised. Lisad: Naised pööravad Blairist ära; Blairi käsikiri otsis kõmulehe lugejate toetust

  12. ASEAN rühib mööda USAst ja Euroopast

    Index Scriptorium Estoniae

    2004-01-01

    Vientianis toimunud ASEAN-i ja Hiina tippkohtumisel kirjutati alla ASEAN-i ja Hiina koostööleppele, mille siht on kõikide nendevaheliste tollipiiride kaotamine aastaks 2010. ASEAN-i ja USA ning ASEAN-i ja Euroopa vahelise kaubanduse mahust

  13. Briti peaminister Tony Blair rühib ajaloolisele kolmandale võidule / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2005-01-01

    Suurbritannias algas parlamendivalimiste kampaania. Arvamusküsitluste kohaselt on Tony Blairil võimalus võita esimese leiboristist peaministrina kolmandad järjestikused valimised. Lisad: Naised pööravad Blairist ära; Blairi käsikiri otsis kõmulehe lugejate toetust

  14. Holland rühib valitsuskriisist uue kaose poole / Jeroen Bult

    Index Scriptorium Estoniae

    Bult, Jeroen

    2006-01-01

    Hollandi valitsuskriisist. Peaminister Balkenende koalitsioonivalitsuse üks osapooltest, D66 partei, loobus valitsuse toetamisest, kuna immigratsiooniminister Rita Verdonk nõudis kodakondsuse äravõtmist Somaalia päritolu endiselt seadusandjalt Ayaan Hirsi Alilt, kes olevat Hollandisse tulles esitanud immigratsiooniametnikele valeandmeid. Autor kritiseerib tagasi astunud valitsuse ja peaminister Balkenende tegevust ning prognoosib sündmusi uue valitsuse moodustamisel

  15. VAKSIN HAEMOPHILUS INFLUENZAE type b (Hib UNTUK PENCEGAHAN MENINGITIS DAN PNEUMONIA

    Directory of Open Access Journals (Sweden)

    Muljati Prijanto

    2012-09-01

    Full Text Available Rendahnya insiden pada anak yang lebih tua umurnya dan orang dewasa disebabkan karena adanya antibodi bakterisidal terhadap capsul polisakarida Haemophilus influenzae tipe b dalam serumnya.Di negara maju maupun negara berkembang bakteri merupakan penyebab utama non epidemik meningitis pada kelompok umur tersebut. Beberapa bukti menunjukkan bahwa mortalitas meningitis pada kelompok bayi muda lebih tinggi di negara berkembang dari pada di negara industri. 

  16. Holland rühib valitsuskriisist uue kaose poole / Jeroen Bult

    Index Scriptorium Estoniae

    Bult, Jeroen

    2006-01-01

    Hollandi valitsuskriisist. Peaminister Balkenende koalitsioonivalitsuse üks osapooltest, D66 partei, loobus valitsuse toetamisest, kuna immigratsiooniminister Rita Verdonk nõudis kodakondsuse äravõtmist Somaalia päritolu endiselt seadusandjalt Ayaan Hirsi Alilt, kes olevat Hollandisse tulles esitanud immigratsiooniametnikele valeandmeid. Autor kritiseerib tagasi astunud valitsuse ja peaminister Balkenende tegevust ning prognoosib sündmusi uue valitsuse moodustamisel

  17. Geometric constraints on the space of N=2 SCFTs II: Construction of special K\\"ahler geometries and RG flows

    CERN Document Server

    Argyres, Philip C; Lü, Yongchao; Martone, Mario

    2016-01-01

    This is the second in a series of three papers on systematic analysis of rank 1 Coulomb branch geometries of four dimensional N=2 SCFTs. In \\cite{Argyres:2015ffa} we developed a strategy for classifying physical rank-1 CB geometries of N=2 SCFTs. Here we show how to carry out this strategy computationally to construct the Seiberg-Witten curves and one-forms for all the rank-1 SCFTs. Explicit expressions are given for all cases, with the exception of the Nf=4 SU(2) gauge theory and the En SCFTs which were constructed in \\cite{Seiberg:1994rs,Seiberg:1994aj} and \\cite{Minahan:1996fg,Minahan:1996cj}. Our classification includes all known rank-1 theories plus a new one with an abelian flavor group, plus nine additional theories whose existence is more speculative. Four of those, reported in \\cite{Argyres:2015ffa}, depend on the assumption of new frozen rank-1 SCFTs. Here we also also show that the assumption of the existence of certain rank-0 N=2 SCFTs leads to five additional consistent rank-1 CB geometries.

  18. 数学建模竞赛活动浅析%An Preliminary Exploration on Mathematical Contest in Moteling Activity

    Institute of Scientific and Technical Information of China (English)

    刘琼; 黄雪燕

    2006-01-01

    钦州师专数学建模的现状及主要问题是学生对数学建模认识不够深刻,教师指导竞赛活动的积极性不高.为此,学校应建立竞赛机制,广泛开展数学建模教学,尽快建立一套完整的管理机制.

  19. 29 CFR 779.381 - Establishments within special exceptions or exemptions.

    Science.gov (United States)

    2010-07-01

    ... exceptions provided in the 1961 amendments for hotels, motels, restaurants, hospitals, institutions for the..., motels, and restaurants continue to be eligible for exemption under section 13(a)(2), but must meet all... service establishment. Hotels and Motels...

  20. 23 CFR Table 1 to Part 772 - Noise Abatement Criteria

    Science.gov (United States)

    2010-04-01

    ... areas, parks, residences, motels, hotels, schools, churches, libraries, and hospitals. C 72 (Exterior... Undeveloped lands. E 52 (Interior) 55 (Interior) Residences, motels, hotels, public meeting rooms,...

  1. 29 CFR 779.338 - Effect of 1961 and 1966 amendments.

    Science.gov (United States)

    2010-07-01

    ... were: Hotels, motels, restaurants, motion picture theaters, seasonally operated amusement or..., motels, and restaurants must meet the same tests as other retail or service establishments (see §...

  2. Health Information in Portuguese (português): MedlinePlus

    Science.gov (United States)

    ... b (Hib) Vaccine - English Vacina Contra Influenzae Haemophilus tipo B (Hib) - português (Portuguese) PDF Immunization Action Coalition; ... b (Hib) Vaccine - English Vacina Contra Influenzae Haemophilus tipo B (Hib) - português (Portuguese) PDF Immunization Action Coalition; ...

  3. 16 CFR 802.2 - Certain acquisitions of real property assets.

    Science.gov (United States)

    2010-01-01

    ...) Hotels and motels. (1) An acquisition of a hotel or motel, its improvements such as golf, swimming... incidental to the ownership and operation of the hotel or motel (e.g., prepaid taxes or insurance, management contracts and licenses to use trademarks associated with the hotel or motel being acquired) shall be...

  4. Iraagi sõja valede kiuste rühib Tony Blair taas valimisvõidule / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2005-01-01

    Sõda Iraagis on tõusnud Suurbritannia parlamendivalimiste kampaanias põhiteemaks. Viimase küsitluse andmeid parteide toetuse kohta. Lisad: Salaettekanded tulid avalikuks; Valimisprogrammil pole tähtsust

  5. The effect of zinc supplementation during pregnancy on immune response to Hib and BCG vaccines in Bangladesh

    NARCIS (Netherlands)

    Osendarp, S.J.M.; Fuchs, G.J.; Raaij, van J.M.A.; Mahmud, H.; Tofail, F.; Black, R.E.; Prabhakar, H.; Santosham, M.

    2006-01-01

    An essential role for zinc in development of the fetal immune system has been documented. However, the effect of antenatal zinc supplementation on infants' postnatal immune response to vaccinations is unknown. The objective of this study was to evaluate the effect of zinc supplementation during preg

  6. The effect of zinc supplementation during pregnancy on immune response to Hib and BCG vaccines in Bangladesh

    NARCIS (Netherlands)

    Osendarp, S.J.M.; Fuchs, G.J.; Raaij, van J.M.A.; Mahmud, H.; Tofail, F.; Black, R.E.; Prabhakar, H.; Santosham, M.

    2006-01-01

    An essential role for zinc in development of the fetal immune system has been documented. However, the effect of antenatal zinc supplementation on infants' postnatal immune response to vaccinations is unknown. The objective of this study was to evaluate the effect of zinc supplementation during

  7. The K(a)ihler-Ricci Flow on K(a)hler Manifolds with 2-Non-negative Traceless Bisectional Curvature Operator

    Institute of Scientific and Technical Information of China (English)

    Xiuxiong CHEN; Haozhao LI

    2008-01-01

    The authors show that the 2-non-negative traceless bisectional curvature is preserved along the K(a)hler-Ricci flow.The positivity of Ricci curvature is also preserved along the K(a)hler-Ricci flow with 2-non-negative traceless bisectional curvature.As a corollary,the K(a)hler-Ricci flow with 2-non-negative traceless bisectional curvature will converge to a K(a)hler-Ricci soliton in the sense of Cheeger-Gromov-Hausdorff topology if complex dimension n≥3.

  8. Comparative Study on the Development and Types of Motels%世界主要汽车旅馆类型对比研究

    Institute of Scientific and Technical Information of China (English)

    徐海峰; 赵俊

    2015-01-01

    随着世界经济的发展,自驾旅行兴起并快速发展,由此形成了对汽车旅馆的需求,汽车旅馆作为独立的住宿业态从经济型酒店中分离出来.目前的汽车旅馆主要存在两种形态:欧美传统形式的汽车旅馆和日本及我国台湾地区兴起的新型汽车旅馆.它们在空间地理分布、市场定位、服务功能、建筑形式、室内设计风格等方面各有不同.我国汽车旅馆的发展在借鉴的同时应结合自身特点,形成相应的汽车旅馆形态.

  9. The Feasibility Study of the Development of Motel in China%中国发展汽车旅馆可行性研究

    Institute of Scientific and Technical Information of China (English)

    徐海峰

    2011-01-01

    随着我国经济的发展,自驾游在我国兴起并快速发展,同时,商务公务活动迅速增多,大大增加了居民驾车出行活动,客观上形成了对汽车旅馆的需求.本文首先界定了汽车旅馆的内涵.然后,简要介绍汽车旅馆在全球的发展概况.最后,从经济环境、市场环境、制度环境和行业一般环境等4个方面分析汽车旅馆发展的有利条件,根据供需理论,解析我国市场需求导向的汽车旅馆发展,同时,从宏观环境障碍和市场需求障碍两个方面分析制约因素.

  10. Motels-The New Area for Exploration of China's Hotel Trade%汽车旅馆--中国饭店业拓展的新领域

    Institute of Scientific and Technical Information of China (English)

    郑胜华

    2001-01-01

    作为西方国家一种非常流行的饭店类型--汽车旅馆,以它经济、舒适、方便的特点赢得这些国家民众的喜爱,并成为他们旅游生活中不可缺少的一部分.改革开放以来,中国经济日新月异,已经具备了发展汽车旅馆业的条件.因此,在中国建造汽车旅馆的构想是富有创意和切实可行的.

  11. 中国发展汽车旅馆的前景展望%The outlook of prospect of developing motel in China

    Institute of Scientific and Technical Information of China (English)

    李明月; 景国敏

    2004-01-01

    随着我国经济的发展和人民生活水平的提高,公路体系的不断完善和私人轿车的拥有量不断增长,中国汽车旅馆市场广阔,潜力巨大.本文通过对中国汽车旅馆的现状及发展条件进行分析,提出汽车旅馆业的发展方向和策略.

  12. The Motel Industry in China%我国汽车旅馆业的现状、问题及对策研究

    Institute of Scientific and Technical Information of China (English)

    马桂顺

    2006-01-01

    由于汽车旅馆发展所需的特殊条件以及所服务的消费群体等没有合适的发展空间,所以在西方国家获得了巨大成功的汽车旅馆,在我国却一直没有作为一种饭店形式存在.近几年,我国经济的发展,国民收入水平的提高,都为汽车旅馆的发展提供了机遇.本文在分析影响汽车旅馆发展的基本因素的基础上,针对目前我国汽车旅馆存在的问题尝试性地提出了较可行的一些建议.

  13. Research on the Comparison of Domestic and International Motel%国内外汽车旅馆对比研究

    Institute of Scientific and Technical Information of China (English)

    王丹阳; 邵志伟; 韩龙湖

    2011-01-01

    随着我国社会发展,以高速公路为主体的公路体系的不断改善和经济发展带来的私人汽车的激增,以及这种背景下的人们旅游观念的转变,为汽车旅馆在国内的发展提供了有利条件.通过分析国内汽车旅馆的发展现状,并对国内外汽车旅馆进行了对比研究,为今后汽车旅馆的发展提供借鉴.

  14. Producing high yield seedlings motel of maize variety- Mindan 88%玉米闽单88高产制种模型研究

    Institute of Scientific and Technical Information of China (English)

    涂前程; 罗英; 杨人震; 许宗得; 钟金仙

    1999-01-01

    采用二次回归正交旋转设计方法,探讨了闽单88玉米的4个主要农艺措施与制种产量的关系.结果显示,各参试因子对产量效应的作用程度依次为:密度>磷肥>氮肥>钾肥.同时,各因子间存在着互作效应.当种植密度在6.75万株/hm2、尿素用量在225 kg/hm2时,制种产量在本试验条件下达最大值(6795 kg/hm2).

  15. 国内汽车旅馆的现状及发展趋势分析%The Analysis of Chinese Motel's Arising

    Institute of Scientific and Technical Information of China (English)

    乐盈; 蒋炯坪

    2004-01-01

    从国际上汽车旅馆产生与发展的进程分析,以高速公路为主体的公路交通条件的完善和一定比例的私人轿车拥有量,以及追求个性化体验的自助旅游者比例的提高,是汽车旅馆存在的前提.我国目前已经具备了形成一定规模的汽车旅馆产业的条件.面对这个机遇,如何借鉴国际上汽车旅馆经营的成熟的经验,克服各种制约因素,体现本国本地的特点,实现汽车旅馆业的可持续发展,是值得我们研究的课题.

  16. Mathematical Motel to Describe Rotating Part Profile%描述回转类零件轮廓的数学模型

    Institute of Scientific and Technical Information of China (English)

    许云

    2000-01-01

    描述回转类零件轮廓的数学模型,可以准确地表达回转类零件表面各点的几何信息,并有利于降低CAPP程序的编写难度.该模型可以处理含有自由曲线轮廓的复杂零件,并可有效地完成对各种复杂回转类零件的粗切加工.

  17. GUIDELINES FOR HOSPITALITY EDUCATION IN JUNIOR COLLEGES, A MANUAL FOR THE ESTABLISHMENT OF PROGRAMS FOR CAREERS IN THE HOTEL-MOTEL, RESTAURANT, AND INSTITUTIONAL INDUSTRIES.

    Science.gov (United States)

    ALMARODE, RICHARD L.

    THIS REPORT DISCUSSES JUNIOR COLLEGE PROGRAMS TO MEET THE NEEDS OF STUDENTS AND INDUSTRY. THE STUDENTS RECEIVE BOTH EDUCATION AND TRAINING, WHILE INDUSTRY RECEIVES COMPETENT EMPLOYEES. BEFORE DEVELOPING THIS OCCUPATIONAL PROGRAM, THE COLLEGE SHOULD SURVEY LOCAL INDUSTRY NEEDS, OPPORTUNITIES FOR ON-THE-JOB TRAINING, POSSIBILITIES OF PART-TIME WORK…

  18. 48 CFR 952.251-70 - Contractor employee travel discounts.

    Science.gov (United States)

    2010-10-01

    ... Federal Contractor employee travelers by AMTRAK, hotels, motels, or car rental companies, when use of such... employees. (d) Hotels/motels. Many lodging providers extend their discount rates for Federal employees...

  19. 75 FR 24434 - Federal Travel Regulation (FTR); Transportation in Conjunction With Official Travel and Relocation

    Science.gov (United States)

    2010-05-05

    ... service furnished by hotels/motels to the maximum extent possible as a first source of transportation... provided by hotels/motels between the place of lodging at the TDY station and the common carrier...

  20. 26 CFR 1.123-1 - Exclusion of insurance proceeds for reimbursement of certain living expenses.

    Science.gov (United States)

    2010-04-01

    ... restaurant. A and his spouse incur expenses of $200 for lodging at a motel, $180 for meals which customarily... of the motel's closer proximity to his place of employment. Other transportation expenses...

  1. 76 FR 62442 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2011-10-07

    .... Historic Columbia R. Hwy., Corbett, 11000771 WYOMING Johnson County Blue Gables Motel, (Motor Courts and Motels in Wyoming MPS), 662 N. Main St., Buffalo, 11000772 In the interest of preservation, the...

  2. Carbon Monoxide Safety

    Science.gov (United States)

    Skip to main content About USFA Hotel/Motel Contact Us Search Email subscriptions Training & Professional Development Fire Prevention & Public Education Operations Management & Safety Data Publications & Library Grants & Funding About USFA Hotel/Motel Contact Us Email subscriptions Home / Fire ...

  3. United States Fire Administration

    Science.gov (United States)

    Skip to main content About USFA Hotel/Motel Contact Us Search Email subscriptions Training & Professional Development Fire Prevention & Public Education Operations Management & Safety Data Publications & Library Grants & Funding About USFA Hotel/Motel Contact Us Email subscriptions Disaster sheltering ...

  4. 26 CFR 1.1250-5 - Property with two or more elements.

    Science.gov (United States)

    2010-04-01

    ... property or properties are disposed of. Thus, for example, if a taxpayer, who owns a motel consisting of 10 buildings with common heating and plumbing systems, adds to the motel three new buildings which are connected to the common systems, and if the taxpayer sells the motel to one person in one transaction,...

  5. 41 CFR 301-11.17 - If my agency authorizes per diem reimbursement, will it reduce my M&IE allowance for a meal(s...

    Science.gov (United States)

    2010-07-01

    ... for a complimentary meal(s) provided by a hotel/motel? 301-11.17 Section 301-11.17 Public Contracts... complimentary meal(s) provided by a hotel/motel? No. A meal provided by a common carrier or a complimentary meal provided by a hotel/motel does not affect your per diem....

  6. 29 CFR 1904.5 - Determination of work-relatedness.

    Science.gov (United States)

    2010-07-01

    ...-related (i) checked into a hotel or motel for one or more days When a traveling employee checks into a hotel, motel, or into an other temporary residence, he or she establishes a “home away from home.” You must evaluate the employee's activities after he or she checks into the hotel, motel, or...

  7. 76 FR 75953 - Homeless Emergency Assistance and Rapid Transition to Housing: Emergency Solutions Grants Program...

    Science.gov (United States)

    2011-12-05

    ...; (4) lives in a hotel or motel; (5) lives in severely overcrowded housing; (6) is exiting an... of application for assistance. The fourth risk factor, ``lives in a hotel or motel,'' is clarified by adding ``and the cost of the hotel or motel is not paid for by federal, state, or local...

  8. 75 FR 65263 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation; Withdrawal of Proposed Rule

    Science.gov (United States)

    2010-10-22

    ... inn, hotel, motel, or other place of lodging, except for an establishment located within a building... ``public accommodations facility'' as ``an inn, hotel, motel, or other place of lodging, including but not..., motel, or other place of lodging, except for an establishment located within a building that...

  9. 76 FR 69753 - Agency Information Collection Activities: Proposed Collection; Comment Request, Federal Hotel and...

    Science.gov (United States)

    2011-11-09

    ...; Comment Request, Federal Hotel and Motel Fire Safety Declaration Form AGENCY: Federal Emergency Management... systems within hotels and motels. DATES: Comments must be submitted on or before January 9, 2012... requires FEMA to establish and maintain a list of hotels, motels, and similar places of...

  10. 29 CFR 779.383 - “Hotel” and “motel” exemptions under section 13(b)(8).

    Science.gov (United States)

    2010-07-01

    ... Service Establishments Hotels and Motels § 779.383 “Hotel” and “motel” exemptions under section 13(b)(8). (a) General. A hotel or motel establishment may qualify for exemption from the Act's overtime pay... employed by an establishment which is a hotel, motel * * *.” The 13(b)(8) exemption is...

  11. Carrier state of Haemophilus influenzae type b (Hib, Streptococcus pneumoniae, Streptococcus pyogenes, Neisseria meningitidis and Corynebacterium diphtheriae among school children in Pokhara, Nepal

    Directory of Open Access Journals (Sweden)

    Dharm Raj Bhatta

    2014-02-01

    Full Text Available Objective: To determine the incidence of carrier state of Haemophilus influenzae type b, Streptococcus pneumoniae (S. pneumoniae, Streptococcus pyogenes, Neisseria meningitidis and Corynebacterium diphtheriae among school children. Methods: Specimen from posterior pharyngeal wall and tonsils were collected on calcium alginate coated swabs from 1 02 participants. Processing of specimen and antimicrobial susceptibility testing was done by standard procedures. Results: Potential pathogens isolated in our study were S. pneumoniae (14.7%, Staphylococcus aureus (12.7%, Corynebacterium diphtheriae (3.9%, Streptococcus pyogenes (3.9% and Haemophilus influenzae (1.9%. Important findings in antibiogram include high resistance of S. pneumoniae to penicillin (73% and resistance of Staphylococcus aureus to oxacillin (23%. Conclusions: Pharyngeal colonization by S. pneumoniae among school children was found high and there is need of introduction of pneumococcal vaccines among children. Despite expected universal vaccination, pharyngeal colonization by Corynebacterium diphtheriae is possible and there is possibility of transmission.

  12. The current situation of voluntary vaccination and the factors influencing its coverage among children in Takatsuki, Japan: focus on Hib and pneumococcal vaccines.

    Science.gov (United States)

    Tsuda, Yuko; Watanabe, Misuzu; Tanimoto, Yoshimi; Hayashida, Itsushi; Kusabiraki, Toshiyuki; Komiyama, Maki; Kono, Koichi

    2015-03-01

    This study aimed to understand the current scenario of voluntary vaccination and the factors influencing its coverage among 18-month-old children of Takatsuki City, Japan. Based on 1167 parents responses, we found that voluntary vaccination coverage rates were low when compared with routine vaccination rates. The children who were not the first born of the family and who had young and poorly educated parents were less likely to receive voluntary vaccination. Japanese government-supported vaccines, such as Haemophilus influenzae type b and pneumococcal vaccine, had a higher coverage than the vaccines for which parents had to bear the entire vaccination cost. Furthermore, it was found that mass communication media and family pediatricians were effective means to disseminate voluntary vaccination-related information. We envisage that an active participation of medical professionals, easy access to vaccinations, and mass awareness programs will increase voluntary vaccination coverage in Takatsuki.

  13. SAFETY OF COMBINED INJECTION OF VACCINES AGAINST HIB-INFECTION (the data on pilot project fulfilled in Murmansk region and Yaroslavl

    Directory of Open Access Journals (Sweden)

    S.M. Kharit

    2009-01-01

    Full Text Available The results of an observation of 288 children under the age 3–20 months old (46 healthy infants and 142 patients with allergic diseases, residual lesions of CNS, frequently ailing ones and infants with other pathologies, vaccinated and re-vaccinated with Hiberix and Infanrix in one syringe were analyzed. High safety of such method of injection allowed decreasing of injection load during the vaccination against hemophilic infection type b in infants. Common moderate reaction was detected in only one child (0,5%. Topical reactions were registered in 5,0% of vaccinated patients.Key words: children, hemophilic infection, vaccination, post-vaccinal period, safety.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6:36-41

  14. Holomorphic Cartan geometries and rational curves

    CERN Document Server

    Biswas, Indranil

    2010-01-01

    We prove that any compact K\\"ahler manifold bearing a holomorphic Cartan geometry contains a rational curve just when the Cartan geometry is inherited from a holomorphic Cartan geometry on a lower dimensional compact K\\"ahler manifold.

  15. Towards a sustainable, quality and affordable Haemophilus influenzae type b vaccine for every child in the world

    NARCIS (Netherlands)

    Hamidi, A.

    2016-01-01

    Haemophilus influenzae type b (Hib) conjugate vaccine is a safe and effective vaccine that can prevent meningitis and pneumonia caused by Hib disease. Hib vaccine is recommended for all children under 5 years. Despite the availability of safe and effective Hib vaccines since early 1987, Gambia was

  16. Towards a sustainable, quality and affordable Haemophilus influenzae type b vaccine for every child in the world

    NARCIS (Netherlands)

    Hamidi, A.

    2016-01-01

    Haemophilus influenzae type b (Hib) conjugate vaccine is a safe and effective vaccine that can prevent meningitis and pneumonia caused by Hib disease. Hib vaccine is recommended for all children under 5 years. Despite the availability of safe and effective Hib vaccines since early 1987, Gambia was t

  17. Spiraling Beam Illumination Uniformity on Heavy Ion Fusion Target

    CERN Document Server

    Kurosaki, T; Noguchi, K; Koseki, S; Barada, D; Ma, Y Y; Ogoyski, A I; Barnard, J J; Logan, B G

    2012-01-01

    A few percent wobbling-beam illumination nonuniformity is realized in heavy ion inertial confinement fusion (HIF) by a spiraling beam axis motion in the paper. So far the wobbling heavy ion beam (HIB) illumination was proposed to realize a uniform implosion in HIF. However, the initial imprint of the wobbling HIBs was a serious problem and introduces a large unacceptable energy deposition nonuniformity. In the wobbling HIBs illumination, the illumination nonuniformity oscillates in time and space. The oscillating-HIB energy deposition may contribute to the reduction of the HIBs illumination nonuniformity. The wobbling HIBs can be generated in HIB accelerators and the oscillating frequency may be several 100MHz-1GHz. Three-dimensional HIBs illumination computations presented here show that the few percent wobbling HIBs illumination nonuniformity oscillates successfully with the same wobbling HIBs frequency.

  18. Kähler forms and cosmological solutions in type II supergravities

    CERN Document Server

    Alonso-Alberca, N

    2000-01-01

    We consider cosmological solutions to type II supergravity theories where thespacetime is split into a FRW universe and a K\\"ahler space, which may be takento be Calabi-Yau. The various 2-forms present in the theories are taken to beproportional to the K\\"ahler form associated to the K\\"ahler space.

  19. A randomized, dose-ranging assessment of the immunogenicity and safety of a booster dose of a combined diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b (DTPw-HBV-IPV/Hib) vaccine vs. co-administration of DTPw-HBV/Hib and IPV vaccines in 12 to 24 months old Filipino toddlers

    OpenAIRE

    Quiambao, Beatriz; Van Der Meeren, Olivier; Kolhe, Devayani; Gatchalian, Salvacion

    2012-01-01

    As progress toward global poliovirus eradication continues, more and more countries are moving away from use of oral poliovirus vaccines (OPV) to inactivated poliovirus vaccines (IPV) in national vaccination schedules. Reduction of antigen dose in IPV could increase manufacturing capacity and facilitate the change from OPV to IPV. Combination vaccines reduce the number of injections required to complete vaccination, thus playing an important role in maintaining high vaccine coverage with good...

  20. Incidência de episódios hipotônicos-hiporresponsivos associados à vacina combinada DTP/Hib usada no Programa Nacional de Imunizações Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program

    Directory of Open Access Journals (Sweden)

    Reinaldo M. Martins

    2007-12-01

    Full Text Available OBJETIVO: Avaliar a segurança da vacina combinada de difteria-tétano-coqueluche de células inteiras e Haemophilus influenzae tipo b usada no Programa Nacional de Imunizações, e em especial a incidência de episódios hipotônicos-hiporresponsivos. MÉTODO: Acompanhamento de uma coorte de 21.064 lactentes (20.925 ou 99,7% aderiram ao protocolo de estudo, nas 48 horas após a aplicação da vacina de difteria, tétano, coqueluche de células inteiras e Haemophilus influenzae tipo b em centros de saúde na cidade do Rio de Janeiro, para determinar e investigar eventos adversos graves, espontâneos e solicitados. Cada criança foi monitorada durante somente uma dose. RESULTADOS: A incidência de episódios hipotônicos-hiporresponsivos foi de 1:1.744 doses (casos confirmados e de 1:1.495 doses (casos confirmados mais casos suspeitos. A taxa de incidência de convulsões foi de 1:5.231 doses. Não foram detectados casos de apnéia. Esses resultados são comparáveis àqueles relatados na literatura para a vacina contra difteria-tétano-coqueluche de células inteiras. CONCLUSÃO: A vacina contra difteria, tétano, coqueluche de células inteiras e Haemophilus influenzae tipo b em estudo pode ser usada com segurança no Programa Nacional de Imunizações, de acordo com as precauções e contra-indicações correntes.OBJECTIVE:To evaluate the safety of a combined diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine used on the Brazilian National Immunizations Program, chiefly the incidence of hypotonic-hyporesponsive episodes. METHOD: Follow-up of a cohort of 21,064 infants (20,925 or 99.7% adhered to the study protocol, within 48 hours of vaccination with diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine in health care units in the City of Rio de Janeiro, to ascertain and investigate spontaneous and solicited severe adverse events. Each child was followed-up for one dose only. RESULTS: The rate of hypotonic-hyporesponsive episodes was 1/1,744 doses (confirmed cases and 1/1,495 doses (confirmed plus suspect cases. The rate of convulsions was 1/5,231 doses. No cases of apnea were detected. These results are comparable to those found in the literature with diphtheria-tetanus-whole cell pertussis vaccine. CONCLUSION: The diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine under study can be safely used in the National Immunizations Program, according to the current precautions and contraindications.

  1. 工作压力对台湾地区汽车旅馆柜台人员忧郁情绪的影响%Effect of Job Stress on the Depressive Mood of Motel Receptionists in Taiwan Area

    Institute of Scientific and Technical Information of China (English)

    梁文琪; 李学愚; 洪端良

    2007-01-01

    目的 了解台湾地区汽车旅馆柜台人员实际工作现况,进而探讨其工作压力对忧郁情绪的影响.方法 利用参与式观察及结构式访谈等方式,实地观察及访问台湾地区汽车旅馆内任职的柜台人员.结果 造成忧郁情绪的原因中有23.5%源自于工作压力,由柜台人员自评造成工作压力的主要来源的统计结果显示,以"必须反覆做很多重复性的事务"、"必须随时学习新事物"、"突发状况层出不穷,担心无法应付"等3项的认同高度提高.结论 台湾地区汽车旅馆柜台人员工作压力较大,其忧郁情绪与工作压力有关.

  2. 15 CFR 310.4 - Action on application.

    Science.gov (United States)

    2010-01-01

    .... (3) The relative merit of the applications in terms of their qualifications as tourism destination... industry experts representing tour developers, the transportation, entertainment and hotel/motel...

  3. Native Hawaiian and Pacific Islander Health - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... PDF Health Information Translations Chickenpox Vaccine English Bakuna Laban sa Bulutong-Tubig - Tagalog (Tagalog) PDF Immunization Action ... Haemophilus Influenzae Type b (Hib) Vaccine English Bakuna Laban sa Haemophilus Influenzae Type b (Hib) - Tagalog (Tagalog) ...

  4. About Haemophilus influenzae Disease

    Science.gov (United States)

    ... Hib Vaccination Hib Vaccination Meningitis Pneumonia Sepsis About Haemophilus influenzae Disease Recommend on Facebook Tweet Share Compartir H. ... severe, such as a bloodstream infection. Types of Haemophilus influenzae Infections Infections caused by these bacteria... Causes, How ...

  5. Haemophilus influenzae outer membrane vesicle-induced blood-brain barrier permeability during experimental meningitis.

    OpenAIRE

    Wispelwey, B; Hansen, E J; Scheld, W M

    1989-01-01

    Haemophilus influenzae type b (Hib) lipopolysaccharide (LPS) may be present in the cerebrospinal fluid largely as part of outer membrane vesicles (OMV), which could possibly alter its activity. Similar to inoculation of purified Hib LPS, intracisternal inoculation of Hib OMV into adult rats resulted in dose- and time-dependent increases in blood-brain barrier permeability. Polymyxin B, but not an oligosaccharide-specific monoclonal antibody, significantly inhibited the activity of Hib OMV. No...

  6. [Severe Haemophilus influenzae b infection in healthy male adult

    DEFF Research Database (Denmark)

    Vilmar, A.C.; Gjorup, I.; David, Kim Peter

    2008-01-01

    Haemophilus influenzae b (Hib) can be the cause of serious infections, and is mainly observed affecting children and immuno-compromised patients. We report a case of a healthy 49-year old male with a severe Hib infection complicated by septicaemia, meningitis and anuria. The risk of invasive Hib...

  7. 29 CFR 779.382 - May qualify as exempt 13(a)(2) establishments.

    Science.gov (United States)

    2010-07-01

    ... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Hotels and Motels § 779.382 May qualify as exempt 13(a)(2) establishments. A hotel or motel establishment may qualify as an exempt retail or service establishment under section 13(a)(2) of the Act...

  8. 77 FR 2306 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, Federal...

    Science.gov (United States)

    2012-01-17

    ... automatic fire sprinkler systems. The information is compiled as a National Master List of lodging... Review; Comment Request, Federal Hotel and Motel Fire Safety Declaration Form AGENCY: Federal Emergency... Title: Federal Hotel and Motel Fire Safety Declaration Form. Type of information collection:...

  9. Uma Introdução à Escatologia Hibérnica – Algumas considerações a partir dos textos da Tradição Hiberno-latina

    Directory of Open Access Journals (Sweden)

    Dominique Santos

    2016-01-01

    Full Text Available A partir da análise de alguns textos da assim chamada Tradição Hiberno-Latina, o objetivo deste artigo é mostrar que a visão escatológica destas narrativas passa por um processo de transformação do século V ao XII. Se durante no início do período que a historiografia irlandesa denomina como Early Christian Ireland só havia dois espaços na geografia do além cristão, céu e inferno, posteriormente, devido a influência dos Imramma célticos, esta estrutura é ampliada, com o aparecimento do Purgatorium.

  10. Aplicación del análisis de riesgo en la preparación de soluciones para producción de Quimi-Hib®

    Directory of Open Access Journals (Sweden)

    Yordanka Ojeda

    2013-08-01

    Full Text Available Entre las técnicas avanzadas de administración de riesgo se encuentran las herramientas de soporte estadístico, así como los histogramas y gráficos de frecuencia acumulada, los cuales sirven de base para la acumulación de datos. Se realizó un análisis de los mismos y se evaluó la influencia de diferentes parámetros sobre un proceso determinado para la toma de decisiones. Los resultados obtenidos demostraron que existe riesgo de contaminación de las soluciones en una cabina de flujo laminar. Todos los tampones evaluados cumplieron satisfactoriamente con los límites establecidos para el contenido de endotoxinas y límite microbiano. Los valores de carga microbiana, determinados por diferentes métodos en el ambiente de trabajo, estuvieron dentro de los límites, acorde con la clasificación de las áreas. La higienización de los tanques de preparación demostró que los procedimientos empleados garantizaron una adecuada remoción de los contaminantes. Se concluyó que los riesgos y escenarios evaluados fueron aceptables para alcanzar la calidad del producto.

  11. Praksis som læringsmetode i ingeniørutdanningen – erfaringer fra ingeniørstudiet i undervannsteknologi - drift og vedlikehold ved Høgskolen i Bergen (HiB

    Directory of Open Access Journals (Sweden)

    Laila Linde Lossius

    2014-05-01

    Full Text Available Norsk ingeniørutdanning har blitt kritisert for å være for teoretisk. Næringslivets hovedorganisasjon (NHO m.fl. startet derfor prosjektet «Lærlingeordning i høyere utdannelse». Høgskolen i Bergen dro nytte av erfaringene derfra, og i 2007 – da bachelorstudiet i undervannsteknologi startet – var forutsetningen at studiet skulle ha stor praksisandel og mye kontakt med lokalt næringsliv. Studiet har blitt Norges mest etterspurte treårige ingeniørstudium. Frafallet har vært lavere enn ved andre ingeniørstudier. Studiet har inneholdt flere praksisformer, hvorav bacheloroppgave i bedrift, ingeniørpraksis og verkstedpraksis ble regnet som de mest utbytterike ut fra svar i spørreundersøkelsene. 72 % av studentene anså praksis som en viktig årsak til at de søkte. Faglig interesse og utsikt til gode jobber var dog viktigst. 71 % av studentene opplevde at praksis underveis ville gjøre dem til bedre ingeniører, mens 55 % mente det hadde innvirkning på at de fullførte studiet. Praksisbedriftene har tjent ved bedret rekruttering, de største opptil 0,7 ansatt per praksisplass. Praksisorganisering er krevende, og kvalitetssikring og oppfølging er viktig for å få et godt resultat. Bedriftsnettverk er gode støttespillere, men skolen må også avsette nok ressurser til arbeidet. Siden skader kan skje i industrien, må forsikringsordninger av studenter i praksis settes på den politiske agendaen slik at regelverket kan endres. Summary Norwegian engineering studies has been criticized of being too theoretical. Bergen University College used experiences from the project “Apprenticeship in higher education” when starting the engineering program in Subsea technology in 2007. Much practice and contact with local industry was requested. The program has become popular and dropout is lower than in comparable programs. Student surveys revealed the most rewarding practice to be a company-based Bachelor thesis, engineer internships and workshop internships. 72% indicated that such placements were a reason for applying; professional interest and prospect of jobs were thus more important. 71% said internships would make them better engineers while just 55% said it influenced them in completing their degree. Organizing internships is time consuming and quality assurance and close follow-up are essential for good results. Injuries may happen in industry; it is, therefore, essential to ensure that insurance for students is set on the political agenda.

  12. Immunogenicity, safety and reactogenicity of a booster dose of the 10-valent pneumococcal Nontypeable H. influenzae Protein D conjugate vaccine coadministered with DTPa-IPV-Hib in Dutch children

    NARCIS (Netherlands)

    Van Den Bergh, Menno R.; Spijkerman, Judith; François, Nancy; Swinnen, Kristien; Borys, Dorota; Schuerman, Lode; Veenhoven, Reinier H.; Sanders, Elisabeth A M

    2016-01-01

    Background: Immune responses and safety profiles may be affected when vaccines are coadministered. We evaluated the immunogenicity, safety and reactogenicity of a booster dose of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate (PHiD-CV; Synflorix GSK Vaccines) and

  13. A common source for neutrino and sparticle masses

    CERN Document Server

    Brignole, Andrea; Rossi, Anna

    2010-01-01

    We discuss supersymmetric scenarios in which neutrino masses arise from effective d=6 operators in the Kahler potential (including SUSY-breaking insertions). Simple explicit realizations of those Kahler operators are presented in the context of the type II seesaw. An appealing scenario emerges upon identifying the seesaw mediators with SUSY-breaking messengers.

  14. Spiral wobbling beam illumination uniformity in HIF fuel target implosion

    Directory of Open Access Journals (Sweden)

    Kawata S.

    2013-11-01

    Full Text Available A few % wobbling-beam illumination nonuniformity is realized in heavy ion inertial confinement fusion (HIF throughout the heavy ion beam (HIB driver pulse by a newly introduced spiraling beam axis motion in the first two rotations. The wobbling HIB illumination was proposed to realize a uniform implosion in HIF. However, the initial imprint of the wobbling HIBs was a serious problem and introduces a large unacceptable energy deposition nonuniformity. In the wobbling HIBs illumination, the illumination nonuniformity oscillates in time and space. The oscillating-HIB energy deposition may produce a time-dependent implosion acceleration, which reduces the Rayleigh-Taylor (R-T growth [Laser Part. Beams 11, 757 (1993, Nuclear Inst. Methods in Phys. Res. A 606, 152 (2009, Phys. Plasmas 19, 024503 (2012] and the implosion nonuniformity. The wobbling HIBs can be generated in HIB accelerators and the oscillating frequency may be several 100 MHz ∼ 1 GHz [Phys. Rev. Lett. 104, 254801 (2010]. Three-dimensional HIBs illumination computations present that the few % wobbling HIBs illumination nonuniformity oscillates with the same wobbling HIBs frequency.

  15. Characterization of Park Visitors, Visitation Levels, and Associated Economic Impacts of Recreation at Bull Shoals, Norfork, and Table Rock Lakes

    Science.gov (United States)

    2010-11-01

    within 30 miles of the lake • Non-local Camping Trip: party staying overnight in the local area and reporting local camping expenses • Non-local Motel ...Trip: party staying overnight in the local area and reporting local motel expenses • Other Non-local Overnight Trip: party reporting a local... motel trips 52 19 211 282 Non-local other overnight trips 49 23 78 150 Local day trips 371 209 148 728 Local other overnight trips 58 35 29 122 Total

  16. Immunogenicity, reactogenicity and consistency of production of a Brazilian combined vaccine against diphtheria, tetanus, pertussis and Haemophilus influenzae type b

    Directory of Open Access Journals (Sweden)

    Reinaldo de Menezes Martins

    2008-11-01

    Full Text Available A randomized, double-blinded study evaluating the immunogenicity, safety and consistency of production of a combined diphtheria-tetanus-pertussis-Haemophilus influenzae type b vaccine entirely produced in Brazil by Bio-Manguinhos and Instituto Butantan (DTP/Hib-BM was undertaken. The reference vaccine had the same DTP vaccine but the Hib component was produced using purified materials supplied by GlaxoSmithKline (DTP/Hib-GSK, which is registered and has supplied the Brazilian National Immunization Program for over more than five years. One thousand infants were recruited for the study and received vaccinations at two, four and six months of age. With respect to immunogenicity, the vaccination protocol was followed in 95.6% and 98.4% of infants in the DTP/Hib-BM and DTP/Hib-GSK groups, respectively. For the Hib component of the study, there was 100% seroprotection (>0.15 µg/mL with all three lots of DTP/Hib-BM and DTP/Hib-GSK. The geometric mean titer (GMT was 9.3 µg/mL, 10.3 µg/mL and 10.3 µg/mL for lots 1, 2 and 3 of DTP/Hib-BM, respectively, and the GMT was 11.3 g/mL for DTP/Hib-GSK. For diphtheria, tetanus and pertussis, seroprotection was 99.7%, 100% and 99.9%, respectively, for DTP/Hib-BM, three lots altogether and 99.2%, 100% and 100% for DTP/Hib-GSK. GMTs were similar across all lots and vaccines. Adverse events rates were comparable among the vaccine groups. The Brazilian DTP/Hib vaccine demonstrated an immunogenicity and reactogenicity profile similar to that of the reference vaccine.

  17. Electron Density Modification of Single Wall Carbon Nanotubes (SWCNT by Liquid-Phase Molecular Adsorption of Hexaiodobenzene

    Directory of Open Access Journals (Sweden)

    Hirofumi Kanoh

    2013-02-01

    Full Text Available Electron density of single wall carbon nanotubes (SWCNT is effectively modified by hexaiodobenzene (HIB molecules using liquid-phase adsorption. UV-Vis-NIR absorption spectra of the HIB-adsorbed SWCNT, especially in the NIR region, showed a disappearance of S11 transitions between the V1 valance band and the C1 conduction band of van Hove singularities which can be attributed to the effective charge transfer between HIB and the SWCNT. The adsorption of HIB also caused significant peak-shifts (lower frequency shift around 170 cm−1 and higher shift around 186 cm‑1 and an intensity change (around 100–150 cm−1 and 270–290 cm−1 in the radial breathing mode of Raman spectra. The charge transfer from SWCNT to HIB was further confirmed by the change in the C1s peak of X-ray photoelectron spectrum, revealing the oxidation of carbon in SWCNT upon HIB adsorption.

  18. Haemophilus influenzae serotype a as a cause of serious invasive infections.

    Science.gov (United States)

    Ulanova, Marina; Tsang, Raymond S W

    2014-01-01

    Haemophilus influenzae, particularly H influenzae serotype b (Hib), is an important pathogen that causes serious diseases like meningitis and septicaemia. Since the introduction of Hib conjugate vaccines in the 1990s, the epidemiology of invasive H influenzae disease has changed substantially, with most infections now caused by non-Hib strains. We discuss the importance of H influenzae serotype a (Hia) as a cause of serious morbidity and mortality and its global epidemiology, clinical presentation, microbiology, immunology, prevention, and control. Much like Hib, the capsule of Hia is an important virulence factor contributing to the development of invasive disease. Molecular typing of Hia has identified distinct clonal groups, with some linked to severe disease and high case-fatality rates. Similarities between Hia and Hib capsules, their clinical presentation, and immunology of infection suggest that a bivalent Hia-Hib capsular polysaccharide-protein conjugate vaccine could offer protection against these two important serotypes of H influenzae.

  19. 26 CFR 1.217-2 - Deduction for moving expenses paid or incurred in taxable years beginning after December 31, 1969.

    Science.gov (United States)

    2010-04-01

    ... addition, A detours into Mexico for sightseeing. Because of the stopovers and tour into Mexico, A's travel... a full-time basis as the operator of a motel both before and after the off-season. A taxpayer...

  20. 7 CFR 1980.490 - Business and industry buydown loans.

    Science.gov (United States)

    2010-01-01

    ... reforestation. (iii) The growing of mushrooms or hydroponics. (4) Recreation and tourism. Loans may be guaranteed for tourist or recreation facilities except for hotels, motels, bed and breakfasts, race...

  1. Radioactive Iodine Treatment for Hyperthyroidism

    Science.gov (United States)

    ... least three days. Do not stay in a hotel or motel right after treatment. What are the ... 467-6663) National Endocrine and Metabolic Diseases Information Service: www.endocrine.niddk.nih.gov American Thyroid Association: ...

  2. 30 CFR 715.13 - Postmining use of land.

    Science.gov (United States)

    2010-07-01

    ... buildings, stores, parking facilities, apartment housed, motels, hotels, or similar facilities. (3) Public..., underground and surface utilities, and other servicing structures and appurtenances. (4) Residential. Single... land area of housing capacity, associated open space, and minor vehicle parking and...

  3. Hospitality Industry, US and Territories, 2015, EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains point features that represent hotels and motels, casinos, and casino hotels associated with three NAICS codes. Establishment-specific...

  4. 76 FR 24048 - Notice of Public Meeting, Coeur d'Alene District Resource Advisory Council Meeting; Idaho

    Science.gov (United States)

    2011-04-29

    ....m. The meeting will be held at the Super 8 Motel, 801 SW. 1st Street, Grangeville, Idaho 83530. FOR... regarding an alternative site for ATV use based on the Community Corrals, Bug Slope site closure....

  5. Spiraling Beam Illumination Uniformity on Heavy Ion Fusion Target

    OpenAIRE

    Kurosaki, T; Kawata, S.; Noguchi, K.; Koseki, S; Barada, D.; Ma, Y. Y.; Ogoyski, A. I.; Barnard, J. J.; Logan, B. G.

    2012-01-01

    A few percent wobbling-beam illumination nonuniformity is realized in heavy ion inertial confinement fusion (HIF) by a spiraling beam axis motion in the paper. So far the wobbling heavy ion beam (HIB) illumination was proposed to realize a uniform implosion in HIF. However, the initial imprint of the wobbling HIBs was a serious problem and introduces a large unacceptable energy deposition nonuniformity. In the wobbling HIBs illumination, the illumination nonuniformity oscillates in time and s...

  6. Pentavalent DTP vaccine: need to be incorporated in the vaccination program of India.

    Science.gov (United States)

    Verma, Ramesh; Khanna, Pardeep; Chawla, Suraj

    2013-07-01

    Hemophilus influenzae type b (Hib) is a leading cause of bacterial meningitis among infants and young children and the second leading cause of bacterial pneumonia deaths among children under 5 y. The overall case-fatality rate for Hib meningitis is 20-29%, and nearly 30% of surviving children suffer from major disabilities, while all invasive Hib disease (including meningitis) has a case fatality rate of 16% in India. Using the estimates from the Hib study, ~215,000 new cases of Hib pneumonia occur yearly in Indian children under the age of 5 y and result in over 61,000 deaths. This level of mortality is because of poor access to health services and poor health-seeking behavior by population, lack of laboratory infrastructure, and difficulty to diagnosis Hib disease among affected children. Disease burden is difficult to calculate. Even for those affected children who do reach healthcare facilities, the lack of quality health services and increasing prevalence of antibiotic-resistance makes treatment difficult for these children. Even in countries that have poor immunization coverage, indirect benefits of the Hib vaccine have been reported due to the herd effect. The Hib vaccine thus should be effective in India where Universal Immunization Programme (UIP) coverage is poor. Following the World Health Organization (WHO) recommendation that Hib-containing Pentavalent DTP vaccine (a combination vaccine that protects against five killer diseases: diphtheria, pertussis, tetanus, hepatitis B [hepB] and Hib) should be administered to every child in the world, the Government of India asked the National Technical Advisory Group on Immunization (NTAGI) to study the need for HepB and Hib vaccines in the Indian population. The India Ministry of Health and Family Welfare introduced Pentavalent DTP vaccines in the UIP with the aim of reducing the burden of Hib-related morbidity and mortality.

  7. In vivo activity of cefcapene proxetil in the experimental motel of mouse septicemia infected by bacteria%头孢卡品酯对细菌感染小鼠败血症的体内抗菌作用研究报告

    Institute of Scientific and Technical Information of China (English)

    钟巍; 李耘; 吕媛; 李曼宁; 刘健

    2013-01-01

    目的 评价头孢卡品酯对我国近三年临床分离致病菌所致小鼠败血症的体内抗菌作用.方法 以0.5mL最小致死量(MLD)腹腔注射细菌感染小鼠,建立小鼠败血症实验模型,灌胃0.5mL不同剂量的抗菌药物,记录给药后1~7d内小鼠成活率,用BLISS法计算50%、95%有效剂量(ED50、ED95)及P值.结果 对4株临床分离致病菌进行了体内保护试验.结果显示,头孢卡品酯对不产ESBLs的大肠埃希菌、肺炎克雷伯菌以及甲氧西林敏感金葡菌、青霉素敏感肺炎链球菌的ED50值在0.381~3.613mg/kg,ED95值在1.304-17.939mg/kg.结论 头孢卡品酯对所测革兰阴性菌的体内抗菌作用优于革兰阳性菌.对体外抗菌活性优于头孢泊肟的菌株,体内抗菌作用也基本优于头孢泊肟酯.%Objective Evaluate the in vivo activity of Cefcapene proxetil in the experimental therapy of mouse septicemia caused by clinical isolated pathogenic bacteria in recent years in China. Methods The mice were intraperitoneally injected with 0.5mL minimum lethal dose (MLD) bacteria and experimental model of mouse septicemia was established. Cefcapene proxetil and Cefpodoxime proxetil were each oral administered in a single dose. The survival of the infected mice were monitored for 7 days, and the 50%, 95% effective dose (ED50 and ED95) was determined by the BLISS method. Results The ED50 and ED95 of Cefcapene proxetil against extended-spectrum beta-lactamase (ESBL) negative Escherichia coli, ESBL negative Klebsiella peumoniae, methicillin susceptibility Staphylococcus aureus (MSSA) and penicillin susceptibility Streptococcus pneumoniae were 0.267-8.081 mg/kg and 2.308-25.452 mg/kg, which were almost the same as that of cefpodoxime proxetil. CONCLUSLON: Cefcapene proxetil showed a good in vivo activity for gram-positive and negative bacterial.

  8. The Evaluation of Water Conservation for Municipal and Industrial Water Supply: Illustrative Examples. Water Conservation and Supply Information Transfer and Analysis Program. Revision.

    Science.gov (United States)

    1981-02-01

    percent is for toilets and none is for showers. (Although there are showers in hotels /motels, this consumption is small when compared to the total...commercial consumption. Since hotels /motels pay the water bill for guests, it is in their best interest to install water conserving showers and many have...appointment on the enclosed form and return it to us. Upon our arrival in Tucson we will call to confirm the appointment. We will be staying at the Marriot

  9. Characterization of the antibody response to a Haemophilus influenzae type b conjugate vaccine in children with recurrent lower respiratory tract infection

    DEFF Research Database (Denmark)

    Kristensen, K; Barington, T; Pressler, T

    1995-01-01

    once with a Haemophilus influenzae type b (Hib) conjugate vaccine. Total IgG subclasses, total antipolysaccharide Hib antibodies, and antipolysaccharide Hib antibodies of IgM, IgG, IgA, and IgG1-4 specificity were determined by ELISA. There were no significant differences between the two groups in any......M response to Hib conjugate vaccine in these children, since this isotype predominates in the primary immune response, i.e., in the absence of immunologic memory.(ABSTRACT TRUNCATED AT 250 WORDS)...

  10. Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials.

    Science.gov (United States)

    Bryant, Kristina; McVernon, Jodie; Marchant, Colin; Nolan, Terry; Marshall, Gary; Richmond, Peter; Marshall, Helen; Nissen, Michael; Lambert, Stephen; Aris, Emmanuel; Mesaros, Narcisa; Miller, Jacqueline

    2012-08-01

    A pooled analysis was conducted of 1257 toddlers who received a fourth dose of Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783). Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.

  11. Researches on a reactor core in heavy ion inertial fusion

    CERN Document Server

    Kondo, S; Iinuma, T; Kubo, K; Kato, H; Kawata, S; Ogoyski, A I

    2016-01-01

    In this paper a study on a fusion reactor core is presented in heavy ion inertial fusion (HIF), including the heavy ion beam (HIB) transport in a fusion reactor, a HIB interaction with a background gas, reactor cavity gas dynamics, the reactor gas backflow to the beam lines, and a HIB fusion reactor design. The HIB has remarkable preferable features to release the fusion energy in inertial fusion: in particle accelerators HIBs are generated with a high driver efficiency of ~30-40%, and the HIB ions deposit their energy inside of materials. Therefore, a requirement for the fusion target energy gain is relatively low, that would be ~50 to operate a HIF fusion reactor with a standard energy output of 1GW of electricity. In a fusion reactor the HIB charge neutralization is needed for a ballistic HIB transport. Multiple mechanical shutters would be installed at each HIB port at the reactor wall to stop the blast waves and the chamber gas backflow, so that the accelerator final elements would be protected from the ...

  12. Spins and charges in Grassmann space and Kähler spinors in space of differential forms

    CERN Document Server

    Borstnik, Norma Mankoc; Borstnik, Norma Mankoc; Nielsen, Holger Bech

    1999-01-01

    One of us got spins and charges of not only scalars and vectors but also of spinors out of fields, which are antisymmetric tensor fields. Kahler got spins of spinors out of differential forms, which again are antisymmetric tensor fields. Using our simple Grassmann formulation of spins and charges of either spinors or vectors and comparing it to the Dirac-Kahler formulation of spinors, we generalize the Dirac-Kahler approach to vector internal degrees of freedom and to charges of either spinors or vectors and tenzors and point out how at all spinors can appear in both approaches.

  13. Lower bounds on the modified K-energy and complex deformations

    OpenAIRE

    Clarke, Andrew; Tipler, Carl

    2013-01-01

    Let (X,L) be a polarized K\\"ahler manifold that admits an extremal K\\"ahler metric in c1(L). We show that on a nearby polarized deformation that preserves the symmetry induced by the extremal vector field of (X,L), the modified K-energy is bounded from below. This generalizes a result of Chen, Sz\\'ekelyhidi and Tosatti to extremal metrics. Our proof also extends a convexity inequality on the space of K\\"ahler potentials due to X.X. Chen to the extremal metric setup. As an application, we comp...

  14. Preclinical evaluation of a Haemophilus influenzae type b conjugate vaccine process intended for technology transfer.

    Science.gov (United States)

    Hamidi, Ahd; Verdijk, Pauline; Kreeftenberg, Hans

    2014-01-01

    Introduction of Haemophilus influenzae type b (Hib) vaccine in low- and middle-income countries has been limited by cost and availability of Hib conjugate vaccines for a long time. It was previously recognized by the Institute for Translational Vaccinology (Intravacc, originating from the former Vaccinology Unit of the National Institute of Public Health [RIVM] and the Netherlands Vaccine Institute [NVI]) that local production of a Hib conjugate vaccine would increase the affordability and sustainability of the vaccine and thereby help to speed up Hib introduction in these countries. A new affordable and a non-infringing production process for a Hib conjugate vaccine was developed, including relevant quality control tests, and the technology was transferred to a number of vaccine manufacturers in India, Indonesia, and China. As part of the Hib technology transfer project managed by Intravacc, a preclinical toxicity study was conducted in the Netherlands to test the safety and immunogenicity of this new Hib conjugate vaccine. The data generated by this study were used by the technology transfer partners to accelerate the clinical development of the new Hib conjugate vaccine. A repeated dose toxicity and local tolerance study in rats was performed to assess the reactogenicity and immunogenicity of a new Hib conjugate vaccine compared to a licensed vaccine. The results showed that the vaccine was well tolerated and immunogenic in rats, no major differences in both safety and immunogenicity in rats were found between the vaccine produced according to the production process developed by Intravacc and the licensed one. Rats may be useful to verify the immunogenicity of Hib conjugate vaccines and for preclinical evaluation. In general, nonclinical evaluation of the new Hib conjugate vaccine, including this proof of concept (safety and immunogenicity study in rats), made it possible for technology transfer partners, having implemented the original process with no changes

  15. Identification of Haemophilus influenzae Type b Isolates by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

    Science.gov (United States)

    Månsson, Viktor; Kostrzewa, Markus; Nilson, Bo; Riesbeck, Kristian

    2015-01-01

    Haemophilus influenzae type b (Hib) is, in contrast to non-type b H. influenzae, associated with severe invasive disease, such as meningitis and epiglottitis, in small children. To date, accurate H. influenzae capsule typing requires PCR, a time-consuming and cumbersome method. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) provides rapid bacterial diagnostics and is increasingly used in clinical microbiology laboratories. Here, MALDI-TOF MS was evaluated as a novel approach to separate Hib from other H. influenzae. PCR-verified Hib and non-Hib reference isolates were selected based on genetic and spectral characteristics. Mass spectra of reference isolates were acquired and used to generate different classification algorithms for Hib/non-Hib differentiation using both ClinProTools and the MALDI Biotyper software. A test series of mass spectra from 33 Hib and 77 non-Hib isolates, all characterized by PCR, was used to evaluate the algorithms. Several algorithms yielded good results, but the two best were a ClinProTools model based on 22 separating peaks and subtyping main spectra (MSPs) using MALDI Biotyper. The ClinProTools model had a sensitivity of 100% and a specificity of 99%, and the results were 98% reproducible using a different MALDI-TOF MS instrument. The Biotyper subtyping MSPs had a sensitivity of 97%, a specificity of 100%, and 93% reproducibility. Our results suggest that it is possible to use MALDI-TOF MS to differentiate Hib from other H. influenzae. This is a promising method for rapidly identifying Hib in unvaccinated populations and for the screening and surveillance of Hib carriage in vaccinated populations. PMID:25926500

  16. Identification of Haemophilus influenzae Type b Isolates by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

    Science.gov (United States)

    Månsson, Viktor; Resman, Fredrik; Kostrzewa, Markus; Nilson, Bo; Riesbeck, Kristian

    2015-07-01

    Haemophilus influenzae type b (Hib) is, in contrast to non-type b H. influenzae, associated with severe invasive disease, such as meningitis and epiglottitis, in small children. To date, accurate H. influenzae capsule typing requires PCR, a time-consuming and cumbersome method. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) provides rapid bacterial diagnostics and is increasingly used in clinical microbiology laboratories. Here, MALDI-TOF MS was evaluated as a novel approach to separate Hib from other H. influenzae. PCR-verified Hib and non-Hib reference isolates were selected based on genetic and spectral characteristics. Mass spectra of reference isolates were acquired and used to generate different classification algorithms for Hib/non-Hib differentiation using both ClinProTools and the MALDI Biotyper software. A test series of mass spectra from 33 Hib and 77 non-Hib isolates, all characterized by PCR, was used to evaluate the algorithms. Several algorithms yielded good results, but the two best were a ClinProTools model based on 22 separating peaks and subtyping main spectra (MSPs) using MALDI Biotyper. The ClinProTools model had a sensitivity of 100% and a specificity of 99%, and the results were 98% reproducible using a different MALDI-TOF MS instrument. The Biotyper subtyping MSPs had a sensitivity of 97%, a specificity of 100%, and 93% reproducibility. Our results suggest that it is possible to use MALDI-TOF MS to differentiate Hib from other H. influenzae. This is a promising method for rapidly identifying Hib in unvaccinated populations and for the screening and surveillance of Hib carriage in vaccinated populations.

  17. Incidences of vaccine-preventable Haemophilus influenzae type b pneumonia and meningitis in Indonesian children: hamlet-randomised vaccine-probe trial.

    Science.gov (United States)

    Gessner, Bradford D; Sutanto, Agustinus; Linehan, Mary; Djelantik, I Gusti Gede; Fletcher, Tracy; Gerudug, I Komang; Ingerani; Mercer, David; Moniaga, Vanda; Moulton, Lawrence H; Moulton, Lawrence H; Mulholland, Kim; Nelson, Carib; Soemohardjo, Soewignjo; Steinhoff, Mark; Widjaya, Anton; Stoeckel, Philippe; Maynard, James; Arjoso, Soemarjati

    Most studies of Haemophilus influenzae type b (Hib) disease in Asia have found low rates, and few Asian countries use Hib vaccine in routine immunisation programmes. Whether Hib disease truly is rare or whether many cases remain undetected is unclear. To estimate incidences of vaccine-preventable Hib pneumonia and meningitis among children younger than 2 years in Lombok, Indonesia, during 1998-2002, we undertook a hamlet-randomised, controlled, double-blind vaccine-probe study (818 hamlets). Children were immunised (WHO schedule) with diphtheria, tetanus, pertussis (DTP) or DTP-PRP-T (Hib conjugate) vaccine. Vaccine-preventable disease incidences were calculated as the difference in rates of clinical outcomes between DTP and DTP-PRP-T groups. Analyses included all children who received at least one vaccine dose. We enrolled 55073 children: 28147 were assigned DTP-PRP-T and 26926 DTP. The proportion of pneumonia outcomes prevented by vaccine ranged from less than 0 to 4.8%. Calculated incidences of vaccine-preventable Hib disease (per 10(5) child-years of observation) for outcome categories were: substantial alveolar consolidation or effusion, less than zero (-43 [95% CI -185 to 98]); all severe pneumonia, 264 (95% CI less than zero to 629); all clinical pneumonia, 1561 (270 to 2853); confirmed Hib meningitis, 16 (1.4 to 31); meningitis with cerebrospinal-fluid findings consistent with a bacterial aetiology, 67 (22 to 112); and admission for suspected meningitis or presenting to a clinic with convulsions, 158 (42 to 273). Hib vaccine did not prevent the great majority of pneumonia cases, including those with alveolar consolidation. These results do not support a major role for Hib vaccine in overall pneumonia-prevention programmes. Nevertheless, the study identified high incidences of Hib meningitis and pneumonia; inclusion of Hib vaccine in routine infant immunisation programmes in Asia deserves consideration.

  18. Einstein-K(a)hler metric on Cartan-Hartogs domain of the second type

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiaoxia; ZHANG Liyou; YIN Weiping

    2004-01-01

    The Einstein-Kahler metric for the Cartan-Hartogs domain of the second type is described. Firstly, the Monge-Ampère equation for the metric to an ordinary differential equation in the auxiliary function X=X(z,w) is reduced, by which an implicit function in X is obtained. Secondly, for some cases, the explicit forms of the complete Einstein-Kahler metrics on Cartan-Hartogs domains which are the non-homogeneous domains are obtained. Thirdly, the estimate of holomorphic sectional curvature under the Einstein-Kahler metric is given, and in some cases the comparison theorem for Kobayashi metric and Einstein-Kahler metric on Cartan-Hartogs domain of the second type is established.

  19. Isometries, gaugings and N=2 supergravity decoupling

    CERN Document Server

    Antoniadis, Ignatios; Petropoulos, P Marios; Siampos, Konstantinos

    2016-01-01

    We study off-shell rigid limits for the kinetic and scalar-potential terms os a single N=2 hypermultiplet. In the kinetic term, these rigid limits establish relations between four-dimensional quaternion-Kahler and hyper-Kahler target spaces with symmetry. The scalar potential is obtained by gauging the graviphoton along an isometry of the quaternion-Kahler space. The rigid limits unveil two distinct cases. A rigid N=2 theory on Minkowski or on AdS_4 spacetime, depending on whether the isometry is translational or rotational respectively. We apply these results to the quaternion-Kahler space with Heisenberg x U(1) isometry, which describes the universal hypermultiplet at type-II string one-loop.

  20. On the dualization of scalars into (d-2)-forms in supergravity. Momentum maps, R-symmetry and gauged supergravity

    CERN Document Server

    Bandos, Igor A

    2016-01-01

    We review and investigate different aspects of scalar fields in supergravity theories both when they parametrize symmetric spaces and when they parametrize spaces of special holonomy which are not necessarily symmetric (Kahler and Quaternionic-Kahler spaces): their role in the definition of derivatives of the fermions covariant under the R-symmetry group and (in gauged supergravities) under some gauge group, their dualization into (d-2)-forms, their role in the supersymmetry transformation rules (via fermion shifts, for instance) etc. We find a general definition of momentum map that applies to any manifold admitting a Killing vector and coincides with those of the holomorphic and tri-holomorphic momentum maps in Kahler and Quaternionic-Kahler spaces and with an independent definition that can be given in symmetric spaces. We show how the momentum map occurs ubiquitously: in gauge-covariant derivatives of fermions, in fermion shifts, in the supersymmetry transformation rules of (d-2)-forms etc. We also give t...

  1. THEOREMS OF BARTH-LEFSCHETZ TYPE ON K(A..)HLER MANIFOLDS WITH PARTIALLY POSITIVE CURVATURE

    Institute of Scientific and Technical Information of China (English)

    周德堂

    2003-01-01

    The author obtains the theorems of Barth-Lefschetz type on Kahler manifolds with partiallypositive bisectional curvature without the assumption of nonnegative bisectional curvature.Some applications of the results to holomorphic mappings are given.

  2. Paediatric surveillance of invasive infections by Haemophilus influenzae in 1995 in the Netherlands

    NARCIS (Netherlands)

    Talsma E; Conyn-van Spaendonck MAE; Geubbels ELPE; Suijkerbuijk AWM; CIE

    1996-01-01

    Ter voorkoming van sterfte, morbiditeit en blijvende schade als gevolg van invasieve Hib-infecties heeft de Gezondheidsraad geadviseerd vaccinatie tegen Hib in het Rijksvaccinatieprogramma op te nemen, hetgeen in 1993 is gerealiseerd. Om de effectiviteit van deze immunisatie te beoordelen is de sur

  3. Paediatric surveillance of invasive infections by Haemophilus influenzae serotype b in 1994 in the Netherlands

    NARCIS (Netherlands)

    Geubbels ELPE; Conyn-van Spaendonck MAE; Suijkerbuijk AWM; CIE

    1995-01-01

    Ter voorkoming van sterfte, morbiditeit en blijvende schade als gevolg van invasieve Hib-infecties heeft de Gezondheidsraad geadviseerd vaccinatie tegen Hib in het Rijksvaccinatieprogramma op te nemen, hetgeen in 1993 is gerealiseerd. Om het effect van vaccinatie te beoordelen is surveillance geind

  4. Examining Victimization, Bullying, Coping, and Students' Perceptions of Safety in an Urban Elementary School

    Science.gov (United States)

    Andreuzzi-Kovalsky, Cathy

    2014-01-01

    Because of the negative psychological and emotional effects of bullying and its pervasive presence in schools, many states have passed antiharrassment, intimidation, and bullying (HIB) legislation. These laws mandate that all schools implement local antiHIB initiatives to prevent and educate stakeholders about bullying. The purpose of this study…

  5. Study on Haemophilus influenzae type b diseases in China: the past, present and future.

    Science.gov (United States)

    Yang, Y; Shen, X; Jiang, Z; Liu, X; Leng, Z; Lu, D; Rao, J; Liu, J; Chang, L

    1998-09-01

    Meningitis caused by Haemophilus influenzae type b (Hib) is a common and serious disease for which there now are WHO-certified vaccines that are recommended for universal infant immunization in North America and European countries. If these vaccines are to be recommended in Asia, it is necessary to know the incidence, age distribution and clinical outcome of Hib meningitis and other systemic infections in this region. Data on Hib disease in China are scanty. Hib meningitis was common during the 1950s in China, accounting for up to 16% of all of pyogenic meningitis (up to 38% of cases were caused by unknown pathogens), despite severe epidemics of meningococcal meningitis during that period. Since 1989 we have conducted hospital- and community-based etiologic and epidemiologic studies of bacterial meningitis. Hib accounts for 30 to 50% of bacterial meningitis in China. The incidence of Hib meningitis in Hefei City was 10.4 per 100000 children death rate of children by one-third by the year 2000, greater efforts should be made to reduce the mortality of children with pneumonia. Our preliminary study showed that about one-fourth to one-third of cases of pneumonia in Chinese children might be caused by Hib. Therefore Hib vaccination for infants and children in China might be an effective and valuable procedure to achieve the goal.

  6. Haemophilus influenzae serotype a septic arthritis in an immunized central Australian indigenous child.

    Science.gov (United States)

    Fischer, Nicholas J

    2014-04-01

    This article describes a notable case of Haemophilus influenzae serotype a (Hia) septic arthritis in an immunized central Australian indigenous child. Since the widespread immunization for H. influenzae serotype b (Hib) in many indigenous peoples worldwide, there has been an increase in reported cases of Hia, postulating that this serotype is taking over the niche that Hib once occupied in indigenous populations.

  7. Heavy-chain isotype patterns of human antibody-secreting cells induced by Haemophilus influenzae type b conjugate vaccines in relation to age and preimmunity

    DEFF Research Database (Denmark)

    Barington, T; Juul, Lars; Gyhrs, A;

    1994-01-01

    The influence of preexisting immunity on the heavy-chain isotypes of circulating antibody-secreting cells (AbSC) induced by vaccination with Haemophilus influenzae type b (Hib) capsular polysaccharide (HibCP) coupled to tetanus toxoid (TT) or diphtheria toxoid (DT) and by vaccination with TT or DT...

  8. Antibodies against Haemophilus influenzae type b in The Gambia: investigating the extent of protection across age groups.

    Science.gov (United States)

    Idoko, O T; Roberts, E; Cox, M; Jafali, J; Njie-Jobe, J; Mackenzie, G; Ota, M O; Kampmann, B

    2014-08-06

    Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serology. Such data are needed however to predict the susceptibility to Hib at the population level. To determine antibody persistence in 5-6 year old fully vaccinated Gambian children compared with older children, adolescents and young adults, 427 serum samples from healthy 5-37 year old participants were tested for Hib antibodies using VaccZyme Human Anti-Hib ELISA kits. 86% of the children who had received 3 doses of Hib vaccine in infancy had Hib antibody concentrations ≥0.15 mg/l at the age of 5-6 years. This proportion was 76% for adolescents who had also largely been vaccinated and 90% for adults who had never received Hib vaccine. Although most participants had anti-Hib antibody above concentrations putatively defined as protective, significantly fewer had concentrations thought to confer long-term protection. This suggests a population with insufficient or waning antibody that may be susceptible to breakthrough disease and transmission. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Antibody response to Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus toxoid in preterm infants

    DEFF Research Database (Denmark)

    Kristensen, Kim; Gyhrs, A; Lausen, B

    1996-01-01

    OBJECTIVE: To evaluate the antibody response to a Haemophilus influenzae type b capsular polysaccharide (HibCP) tetanus toxoid (TT) conjugate vaccine (HibCP-TT) in preterm infants. SUBJECTS: Thirty-five healthy preterm infants with gestational ages (GA) from 27 to 36 weeks and birth weights from...

  10. Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

    Science.gov (United States)

    Konini, Angjelina; Kang, Mingsong; Moghadas, Seyed M.

    2016-01-01

    Objective. We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes “a” (Hia) and “b” (Hib) in the presence of the preexisting immunity to Hib. Methods. We developed a stochastic simulation model of humoral immune response to investigate the antigenic challenge of a bivalent combined glycoconjugate vaccine and a bivalent unimolecular glycoconjugate vaccine. We compared simulation outcomes in the absence of any preexisting immunity with an already primed immune response having specific memory B cells and/or anti-Hib antibodies. Results. The simulation results show that the preexisting immune responses to Hib or carrier protein (CP) may significantly impede the production of anti-Hia antibodies by a unimolecular vaccine. In contrast, the production of anti-Hia antibodies using a combined vaccine is inhibited only in the presence of CP immune responses. Conclusions. Preexisting immunity to Hib and CP may play a critical role in the development of immune responses against Hia or Hib using bivalent combined and unimolecular vaccine formulations. Our results suggest that a bivalent combined glycoconjugate vaccine with a carrier protein not previously used in Hib conjugate vaccines may be an effective formulation for generating immune responses to protect against both Hib and Hia infections. PMID:27366171

  11. Evaluation of Haemophilus influenzae Type B Conjugate Vaccine (Meningococcal Protein Conjugate in Canadian Infants

    Directory of Open Access Journals (Sweden)

    David W Scheifele

    1994-01-01

    Full Text Available Objective: To assess adverse effects and immune responses with a three-dose series of Haemophilus influenzae type b meningococcal protein conjugate (PedvaxHIB or Hib.OMP vaccine, including any immunological response alterations from concurrent administration with routine vaccines for infants.

  12. Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

    Directory of Open Access Journals (Sweden)

    Angjelina Konini

    2016-01-01

    Full Text Available Objective. We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes “a” (Hia and “b” (Hib in the presence of the preexisting immunity to Hib. Methods. We developed a stochastic simulation model of humoral immune response to investigate the antigenic challenge of a bivalent combined glycoconjugate vaccine and a bivalent unimolecular glycoconjugate vaccine. We compared simulation outcomes in the absence of any preexisting immunity with an already primed immune response having specific memory B cells and/or anti-Hib antibodies. Results. The simulation results show that the preexisting immune responses to Hib or carrier protein (CP may significantly impede the production of anti-Hia antibodies by a unimolecular vaccine. In contrast, the production of anti-Hia antibodies using a combined vaccine is inhibited only in the presence of CP immune responses. Conclusions. Preexisting immunity to Hib and CP may play a critical role in the development of immune responses against Hia or Hib using bivalent combined and unimolecular vaccine formulations. Our results suggest that a bivalent combined glycoconjugate vaccine with a carrier protein not previously used in Hib conjugate vaccines may be an effective formulation for generating immune responses to protect against both Hib and Hia infections.

  13. How Human Information Behaviour Researchers Use Each Other's Work: A Basic Citation Analysis Study

    Science.gov (United States)

    McKechnie, Lynne E. F.; Goodall, George R.; Lajoie-Paquette, Darian; Julien, Heidi

    2005-01-01

    Introduction: The purpose of this study was to determine if and how human information behaviour (HIB) research is used by others. Method: Using ISI Web of Knowledge, a citation analysis was conducted on 155 English-language HIB articles published from 1993 to 2000 in six prominent LIS journals. The bibliometric core of 12 papers was identified.…

  14. Einstein-K(a)hler Metric with Explicit Formula on Super-Cartan Domain of the Fourth Type

    Institute of Scientific and Technical Information of China (English)

    An WANG; Wei Ping YIN

    2006-01-01

    Let YⅣ be the Super-Cartan domain of the fourth type. We reduce the Monge-Ampère equation for the metric to an ordinary differential equation in the auxiliary function X = X(Z, W). This differential equation can be solved to give an implicit function in X. We give the generating function of the Einstein-Kahler metric on YⅣ. We obtain the explicit form of the complete Einstein-Kahler metric on YⅣ for a special case.

  15. Conformal Sigma Models with Anomalous Dimensions and Ricci Solitons

    CERN Document Server

    Nitta, M

    2004-01-01

    We present new non-Ricci-flat Kahler metrics with U(N) and O(N) isometries as target manifolds of conformally invariant sigma models with an anomalous dimension. They are so-called Ricci solitons, special solutions to a Ricci-flow equation. These metrics explicitly contain the anomalous dimension and reduce to Ricci-flat Kahler metrics on the canonical line bundles over certain coset spaces in the limit of vanishing anomalous dimension.

  16. Heavy Ion Beams for Investigation of Thermophysical Properties

    CERN Document Server

    Iosilevskiy, Igor

    2010-01-01

    Perspectives for study of thermophysical properties via uniform quasi-stationary volumetric heating under Heavy Ion Beam (HIB) heating with moderate but realistic energy deposition (~ 1 kJ/g) are under discussion. New quasi-isobaric regime of heating is proposed as combination of the HIB energy deposition with the use of highly dispersed porous material as an irradiating sample. Regime of "tracing saturation curve" is proposed also when heating the evaporating porous materials. Consequent preferences and priorities are emphasized. In frames of this technique HIB could became an uncompetitive tool for study of phase transition phenomenon for a wide number of materials with high-temperature location of critical point. Two important thermophysical problems, which could approve using of HIB facility, are discussed as the first-row candidates. Evaporation in Uranium is one of the most tempting candidates to be studied under HIB heating in such manner. When being successful this experiment has a good chance to reso...

  17. Coverage and causes of missed Haemophilus influenzae type B vaccination in urban and rural areas of Peshawar.

    Science.gov (United States)

    Naeem, Mohammad; Adil, Muhammad; Abbas, Syed Hussain; Khan, Muhammad Zia Ul Islam; Naz, Syeda Maria; Khan, Ayasha; Khan, Muhammad Usman

    2011-01-01

    Haemophilus influenza type b (Hib) is a major cause of morbidity and mortality in Pakistan. Hib vaccine was introduced in 2009 in EPI programme. The purpose of this study was to find out the coverage and factors associated with non-immunization of Hib in urban and rural areas of Peshawar. Data was collected through random sampling in Peshawar University, Peshawar Saddar, Hashtnagri, Naway Kalay and Pawaka from 9th to 19th of June 2010. A questionnaire was used to interview parents of 600 children aged 1 year and below about demographics, Hib vaccination status, reasons for missed vaccination and views on immunization. Pearson's Chi-square test was used for statistical testing, and pfear of reaction (5.4%), child illness (8.1%) and miscellaneous causes (13.7%). Low Hib vaccination coverage in Peshawar is mainly due to low awareness among people, poor economic conditions and illiteracy.

  18. Structural requirements of the major protective antibody to Haemophilus influenzae type b

    DEFF Research Database (Denmark)

    Hougs, L; Juul, L; Svejgaard, A

    1999-01-01

    expressed as antigen-binding fragments (Fabs) in Escherichia coli, define amino acids involved in antigen binding and idiotype expression, and propose a three-dimensional structure for the variable domains. We found that canonical Fabs, unlike a noncanonical Fab, bound effectively to HibCP in the absence......Protective antibodies to the important childhood pathogen Haemophilus influenzae type b (Hib) are directed against the capsular polysaccharide (HibCP). Most of the antibody is encoded by a well-defined set of ("canonical") immunoglobulin genes, including the Vkappa A2 gene, and expresses...... an idiotypic marker (HibId-1). In comparison to noncanonical antibodies, the canonical antibody is generally of higher avidity, shows higher levels of in vitro bactericidal activity, and is more protective in infant rats. Using site-directed mutagenesis, we here characterize canonical HibCP antibodies...

  19. Opposite effects of actively and passively acquired immunity to the carrier on responses of human infants to a Haemophilus influenzae type b conjugate vaccine

    DEFF Research Database (Denmark)

    Barington, T; Gyhrs, A; Kristensen, Kim

    1994-01-01

    Vaccination of infants with Haemophilus influenzae type b (Hib) capsular polysaccharide (HibCP) coupled to carrier proteins has proven protective against invasive Hib diseases in several trials. However, insufficient immunogenicity has been noted in certain populations. Therefore, studies analyzing...... factors influencing the antibody response to conjugate vaccines are needed. In this study, the response to HibCP coupled to tetanus toxoid (TT) was examined in relation to (i) priming with or coadministration of the carrier protein and (ii) the levels of passively acquired maternal TT antibodies. One...... hundred forty-four infants were vaccinated with HibCP-TT at 5 and 6 months. They were randomized into three groups that received TT as part of a diphtheria-tetanus-polio vaccine at either 6 and 7 months (group A), 5 and 6 months (group B), or 4 and 5 months (group C). Maternally acquired TT antibodies...

  20. Heavy Ion Beam in Resolution of the Critical Point Problem for Uranium and Uranium Dioxide

    CERN Document Server

    Iosilevskiy, Igor

    2010-01-01

    Important advantages of heavy ion beam (HIB) irradiation of matter are discussed in comparison with traditional sources - laser heating, electron beam, electrical discharge etc. High penetration length (~ 10 mm) is of primary importance for investigation of dense matter properties. This gives an extraordinary chance to reach the uniform heating regime when HIB irradiation is being used for thermophysical property measurements. Advantages of HIB heating of highly-dispersive samples are claimed for providing free and relatively slow quasi-isobaric heating without fast hydrodynamic expansion of heated sample. Perspective of such HIB application are revised for resolution of long-time thermophysical problems for uranium and uranium-bearing compounds (UO2). The priorities in such HIB development are stressed: preferable energy levels, beam-time duration, beam focusing, deposition of the sample etc.

  1. Co-administration of a novel Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine does not interfere with the immune response to antigens contained in infant vaccines routinely used in the United States.

    Science.gov (United States)

    Marshall, Gary S; Marchant, Colin D; Blatter, Mark; Friedland, Leonard R; Aris, Emmanuel; Miller, Jacqueline M

    2011-02-01

    An investigational combined Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroups C and Y tetanus toxoid conjugate vaccine (HibMenCY-TT) has been developed to protect infants from invasive disease caused by Hib and these meningococcal serogroups without adding injections to the immunization schedule. Incorporation of this novel vaccine into the US vaccination schedule will require demonstration of a lack of immunologic interference with other routine pediatric vaccines. This study assessed the immune response to 7-valent pneumococcal conjugate vaccine (PCV7) and combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine (DTaP-HepB-IPV) when separately co-administered with HibMenCY-TT as compared to a US-licensed H. influenzae type b tetanus toxoid conjugate vaccine (Hib-TT) at 2, 4, 6 (N=606) and 12-15 months of age (N=366). HibMenCY-TT was non-inferior to Hib-TT in terms of antibody responses to all Streptococcus pneumoniae serotypes contained in PCV7 and the diphtheria, tetanus, pertussis, hepatitis B and poliovirus antigens contained in DTaP-HepB-IPV one month after the third vaccine dose, and the anti-tetanus geometric mean antibody concentration (GMC) was significantly higher in the HibMenCY-TT group than in the Hib-TT group. In an exploratory analysis, no significant differences in the proportion of subjects with anti-pneumococcal antibody concentrations ≥0.2 µg/ml or anti-pneumococcal GMC were seen between the two groups after the fourth vaccine dose. A schedule of HibMenCY-TT given concomitantly with PCV7 and DTaP-HepB-IPV would be expected to protect infants against all of the targeted diseases.

  2. Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule

    Directory of Open Access Journals (Sweden)

    Burger Marina

    2008-02-01

    Full Text Available Abstract Background Despite nearly complete vaccine coverage, a small number of fully vaccinated children in the Netherlands have experienced invasive disease caused by Haemophilus influenzae serotype b (Hib. This increase started in 2002, nine years after the introduction of nationwide vaccination in the Netherlands. The capsular polysaccharide of Hib is used as a conjugate vaccine to protect against Hib disease. To evaluate the possible rise of escape variants, explaining the increased number of vaccine failures we analyzed the composition of the capsular genes and the expressed polysaccharide of Dutch Hib strains collected before and after the introduction of Hib vaccination. Results The DNA sequences of the complete capsular gene clusters of 9 Dutch Hib strains were assessed and two variants, designated type I and type II were found. The two variants displayed considerable sequence divergence in the hcsA and hcsB genes, involved in transport of capsular polysaccharide to the cell surface. Application of hcsA type specific PCRs on 670 Hib strains collected from Dutch patients with invasive Hib disease showed that 5% of the strains collected before 1996 were type II. No endogenous type II Hib strains were isolated after 1995 and all type II strains were isolated from 0–4 year old, non-vaccinated children only. Analysis of a worldwide collection of Hib strains from the pre-vaccination era revealed considerable geographic differences in the distribution of the type I and type II strains with up to 73% of type II strains in the USA. NMR analysis of type I and type II capsule polysaccharides did not reveal structural differences. However, type I strains were shown to produce twice as much surface bound capsular polysaccharide. Conclusion Type II strains were only isolated during the pre-vaccination era from young, non-vaccinated individuals and displayed a lower expression of capsular polysaccharide than type I strains. The higher polysaccharide

  3. The relationship between biofilm formations and capsule in Haemophilus influenzae.

    Science.gov (United States)

    Qin, Liang; Kida, Yutaka; Ishiwada, Naruhiko; Ohkusu, Kiyofumi; Kaji, Chiharu; Sakai, Yoshiro; Watanabe, Kiwao; Furumoto, Akitsugu; Ichinose, Akitoyo; Watanabe, Hiroshi

    2014-03-01

    To evaluate the biofilm formation of non-typeable Haemophilus influenzae (NTHi) and H. influenzae type b (Hib) clinical isolates, we conducted the following study. Serotyping and polymerase chain reaction were performed to identify β-lactamase-negative ampicillin (ABPC)-susceptible (BLNAS), β-lactamase-negative ABPC-resistant (BLNAR), TEM-1 type β-lactamase-producing ABPC-resistant (BLPAR)-NTHi, and Hib. Biofilm formation was investigated by microtiter biofilm assay, as well as visually observation with a scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) in a continuous-flow chamber. As a result, totally 99 strains were investigated, and were classified into 4 groups which were 26 gBLNAS, 22 gBLNAR, 28 gBLPAR-NTHi and 23 Hib strains. The mean OD600 in the microtiter biofilm assay of gBLNAS, gBLNAR, gBLPAR-NTHi, and Hib strains were 0.57, 0.50, 0.34, and 0.08, respectively. NTHi strains were similar in terms of biofilm formations, which were observed by SEM and CLSM. Five Hib strains with the alternated type b cap loci showed significantly increased biofilm production than the other Hib strains. In conclusion, gBLNAS, gBLNAR, and gBLPAR-NTHi strains were more capable to produce biofilms compared to Hib strains. Our data suggested that resistant status may not be a key factor but capsule seemed to play an important role in H. influenzae biofilm formation.

  4. Haemophilus influenzae type b and its vaccines%b型流感嗜血杆菌及其疫苗

    Institute of Scientific and Technical Information of China (English)

    尹珊珊; 高正伦; 刘建凯; 郑海发

    2014-01-01

    b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)是导致婴幼儿严重细菌性感染的主要致病菌之一.Hib疫苗的研发和使用大大降低了Hib疾病的发病率.研究显示,Hib结合疫苗可有效预防婴幼儿侵袭性Hib疾病,且具有良好的安全性.此文就Hib的病原学、流行病学及疫苗研究进行综述.%Haemophilus influenzae type b (Hib) is one of the major causes of severe bacterial infections in infants and young children.With development and usage of Hib vaccines,incidence rate of Hib diseases reduces significantly.Researches show that Hib conjugate vaccine can effectively prevent invasive Hib diseases in infants and young children and has good safety.This article reviews etiology,epidemiology and vaccine research of Hib.

  5. Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines

    Directory of Open Access Journals (Sweden)

    Mojgani, N.

    2014-11-01

    Full Text Available Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multiresistant Hib strains causes increasing difficulties in selecting proper antibiotics for the treatment. Since 1970, the capsular polysaccharide polyribosylribitol phosphate (PRP in H. influenzae b has been the target for vaccine development. The first Hib polysaccharide vaccine licensed in 1985, proved immunogenic in human adults, but failed to elicit an immune response in children under 2 years of age who were at greatest risk of developing the invasive Hib infection. These factors led to one of the most exciting advances in pediatrics, the development of Hib conjugate vaccines. Unlike most other vaccines for preventing a particular disease which are generally similar for all types, the specific characteristics of the available Hib conjugate vaccines licensed vary from each other in structure and immunological properties. In this review the immunogenicity and efficacy of Hib vaccines including a PRP vaccine; b Conjugate vaccines; and c Combination vaccines is evaluated.

  6. Cost-benefit analysis of a Haemophilus influenzae type b meningitis prevention programme in The Philippines.

    Science.gov (United States)

    Limcangco, M R; Armour, C L; Salole, E G; Taylor, S J

    2001-01-01

    Haemophilus influenzae type b (Hib) meningitis is associated with high mortality and serious sequelae in children under 5 years of age. Vaccines which can prevent this infection are available. To evaluate the costs and benefits of a 3-dose immunisation schedule in Manila, Philippines. Government and societal perspectives. A cost-benefit analysis based on a birth cohort of 100,000 children. The state of health of the cohort with and without a Hib immunisation programme was modelled over a 5-year period. A survey of medical records of patients with Hib in Manila provided data on the extent and cost of sequelae following infection. A 3-dose Hib vaccination programme given at ages 2, 3 and 4 months. The model predicted that vaccinating children against Hib meningitis would prevent 553 cases per year in a birth cohort of 100,000, at a cost of 56,200 Philippine pesos (PHP) [$US1,605; 1998 exchange rate] per case (base case assumptions of 90% vaccine efficacy rate, 95 per 100,000 Hib incidence rate, 85% vaccination coverage). Results from the cost-benefit analyses indicated that the saving to the government would be around PHP39 million ($US1.11 million), and the saving to society would be PHP255 million ($US7.28 million). There would be a positive economic benefit for the Philippine government and for the Filipino society if a Hib vaccination programme was introduced in Manila.

  7. Longitudinal monitoring adipose-derived stem cell survival by PET imaging hexadecyl-4-{sup 124}I-iodobenzoate in rat myocardial infarction model

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Hwan [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); School of Life Sciences and Biotechnology, Korea University, Seoul (Korea, Republic of); Woo, Sang-Keun; Lee, Kyo Chul; An, Gwang Il [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Pandya, Darpan [Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu (Korea, Republic of); Park, Noh Won; Nahm, Sang-Soep; Eom, Ki Dong [College of Veterinary Medicine, Konkuk University, Seoul (Korea, Republic of); Kim, Kwang Il; Lee, Tae Sup [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Chan Wha [School of Life Sciences and Biotechnology, Korea University, Seoul (Korea, Republic of); Kang, Joo Hyun [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Yoo, Jeongsoo, E-mail: yooj@knu.ac.kr [Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu (Korea, Republic of); Lee, Yong Jin, E-mail: yjlee@kirams.re.kr [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2015-01-02

    Highlights: • We developed a safe, simple and appropriate stem cell labeling method with {sup 124}I-HIB. • ADSC survival can be monitored with PET in MI model via direct labeling. • Tracking of ADSC labeled with {sup 124}I-HIB was possible for 3 days in MI model using PET. • ADSC viability and differentiation were not affected by {sup 124}I-HIB labeling. • Survival of ADSC in living bodies can be longitudinally tracked with PET imaging. - Abstract: This study aims to monitor how the change of cell survival of transplanted adipose-derived stem cells (ADSCs) responds to myocardial infarction (MI) via the hexadecyl-4-{sup 124}I-iodobenzoate ({sup 124}I-HIB) mediated direct labeling method in vivo. Stem cells have shown the potential to improve cardiac function after MI. However, monitoring of the fate of transplanted stem cells at target sites is still unclear. Rat ADSCs were labeled with {sup 124}I-HIB, and radiolabeled ADSCs were transplanted into the myocardium of normal and MI model. In the group of {sup 124}I-HIB-labeled ADSC transplantation, in vivo imaging was performed using small-animal positron emission tomography (PET)/computed tomography (CT) for 9 days. Twenty-one days post-transplantation, histopathological analysis and apoptosis assay were performed. ADSC viability and differentiation were not affected by {sup 124}I-HIB labeling. In vivo tracking of the {sup 124}I-HIB-labeled ADSCs was possible for 9 and 3 days in normal and MI model, respectively. Apoptosis of transplanted cells increased in the MI model compared than that in normal model. We developed a direct labeling agent, {sup 124}I-HIB, and first tried to longitudinally monitor transplanted stem cell to MI. This approach may provide new insights on the roles of stem cell monitoring in living bodies for stem cell therapy from pre-clinical studies to clinical trials.

  8. Haemophilus influenzae type B meningitis: Is there a re-emergence? 24 years of experience in a children's hospital.

    Science.gov (United States)

    Gentile, Angela; Martínez, Ana C; Juarez, María Del V; Lución, María F; Burgo, Candela; Della Latta, María P; Rapapor, Solana; Romanin, Viviana; Turco, Marisa

    2017-06-01

    Haemophilus influenzae type B (Hib) used to be the main cause of bacterial meningitis in children younger than 5 years old. Following the introduction of the Hib vaccine in the immunization schedule (1998), its incidence reduced significantly but it has increased over the last years. The objectives of this study included describing the characteristics and analyzing the epidemic curve of Haemophilus influenzae type B (Hib) meningitis by comparing the pre- and postimmunization periods. Time-series study. All patients hospitalized with Hib meningitis at Hospital de Niños "R. Gutiérrez" (January 1992-May 2016). Hospitalization rates were compared before (pre-immunization) and after (post-immunization) the introduction of the Hib vaccine. The post-immunization period was divided into three similar periods. Eighty-five patients with Hib meningitis were admitted (73.3% in the pre-immunization period). No differences were observed in relation to the clinical and sociodemographic characteristics of cases in both periods. Pre-immunization: 10.5 cases/year; postimmunization: 0.7 cases/year. As of 2014, the rate has increased. Lethality rate: 4.8% (all preimmunization). Post-immunization data (n= 15): 40% had completed their primary immunization schedule, 40% were delayed on the immunization schedule for their age. Overall reduction in the hospital rate of Hib meningitis by 89.8% (95% confidence interval: -82.79-93.96%, p < 0.001) in the post-immunization period. The analysis of the different post-immunization periods shows a decline in reduction over time. A very significant reduction in hospitalizations due to Hib meningitis was observed after the Hib vaccine was introduced; however, over the past years, the number of cases has increased although no changes have been observed in patient characteristics.

  9. The impact of residency and urbanicity on Haemophilus influenzae Type b and pneumococcal immunization in Shanghai Children: a Retrospective Cohort Study.

    Directory of Open Access Journals (Sweden)

    Abram L Wagner

    Full Text Available BACKGROUND: Haemophilus influenzae type b (Hib vaccine and pneumococcal conjugate vaccine (PCV are relatively expensive, newly introduced vaccines in China. This study evaluates the impact of residency and urbanicity on Hib vaccine and PCV coverage for children aged 2 to 7 years living in Shanghai, China, in August 2012. METHODS: In this exploratory cohort study, a sample of children aged 2 to 7 years, all of whom were eligible to have received the complete series of Hib vaccine and PCV, was obtained from the Shanghai Immunization Program Information System. Three measures of vaccination coverage for Hib vaccine and PCV were examined: dose 1 coverage, series completion, and timeliness of dose 1 vaccination. Multivariable binomial regression was used to estimate the difference in vaccination coverage between locals and the floating population. RESULTS: Dose 1 coverage was 50.9% for Hib vaccine and 11.4% for PCV for the 28,141 abstracted pediatric records. For both vaccines, dose 1 coverage was higher in locals than in the floating population. The disparity in coverage between locals and the floating population was greater in suburban areas than urban areas. Of all children who received dose 1, 79.7% completed the Hib vaccine series, and 91.3% completed the PCV series. Timely dose 1 coverage was 8.2% for Hib vaccine and 0.5% for PCV. CONCLUSION: Low vaccination coverage and extremely low levels of timely dose 1 vaccination indicate that current vaccination efforts are inadequate to reduce the burden of Hib and pneumococcal disease among Chinese children, especially infants. Government funding of the Hib vaccine and PCV through the Expanded Program on Immunization would increase uptake and could also ensure that improvement in the timeliness of administration and series completion is targeted for all demographic groups.

  10. Serological Protection Induced by Haemophilus influenzae Type b Conjugate Vaccine in Mexican Children: Is a Booster Dose of the Vaccine Needed? ▿

    Science.gov (United States)

    Rodriguez, Romeo S.; Mascarenas, Cesar; Conde-Glez, Carlos J.; Inostroza, Jaime; Villanueva, Sonia; Velázquez, María Elena; Sánchez-Alemán, Miguel Angel; Echániz, Gabriela

    2010-01-01

    We determined the seroprevalence of protective antibodies against Hib in Mexican children under the age of five using a standardized enzyme-linked immunosorbent assay. Hib antibodies (≥0.15 μg/ml) were present in 95.34% (±1.14% [seroprevalence ± standard error]) of samples. Fewer children aged 30 to 47 months had protective Hib antibody levels (91.45% ± 2.60%) than children from 12 to 29 and 48 to 59 months (97.3% ± 1.34% and 97.44% ± 1.80%, respectively). PMID:20719986

  11. The first reported case of possible Haemophilus influenzae type b vaccine failure from Kuwait and literature-review.

    Science.gov (United States)

    Purohit, Prashant; Al-Obaid, Ina'am Ahmad; Omar, Nehad Gamal Al-Deen

    2014-01-01

    A 17-month-old vaccinated Kuwaiti boy presented with meningitis. The Haemophilus influenzae type b (Hib) capsular antigen was detected in his blood, CSF and urine. The microorganism failed to grow in culture. This case represents the first report of possible Hib vaccine failure from Kuwait. This report examines the possible reasons for this failure by reviewing the literature and emphasizes the need to broaden the definition of vaccine failure with the aim of optimizing the timing of the vaccine booster dose for prematurely born children and establishing continuous surveillance for Hib vaccine failure.

  12. Antibody response to Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus toxoid in preterm infants

    DEFF Research Database (Denmark)

    Kristensen, Kim; Gyhrs, A; Lausen, B

    1996-01-01

    OBJECTIVE: To evaluate the antibody response to a Haemophilus influenzae type b capsular polysaccharide (HibCP) tetanus toxoid (TT) conjugate vaccine (HibCP-TT) in preterm infants. SUBJECTS: Thirty-five healthy preterm infants with gestational ages (GA) from 27 to 36 weeks and birth weights from...... no significant differences among the groups. The response to the TT part of the vaccine showed the same pattern. CONCLUSION: Although the most immature infants may show an inadequate antibody response to the initial immunizations, many preterm infants can benefit from vaccination with HibCP-TT when starting...

  13. Kronisk iskaemisk hjerteinsufficiens. Revaskularisering bedrer overlevelsen blandt patienter med hibernating myocardium

    DEFF Research Database (Denmark)

    Holdgaard, Paw Chr; Nielsen, Søren Steen; Wiggers, Henrik

    2007-01-01

    in patients tested for HIB and relate the results to the choice of treatment and cause of death. MATERIALS AND METHODS: During a 2-year period 51 patients were referred to determine the amount of HIB. This can be determined with blood flow and metabolic imaging of the heart. Resting-myocardial perfusion...... imaging was performed with 99mTc-sestamibi and glucose metabolism was visualized with 18F-fluorodeoxyglucose (18F-FDG) gamma camera PET. Medical records and death certificate were reviewed retrospectively. RESULTS: 50 patients were included. We found an increased survival among patients with HIB who...

  14. HOSP 320 Discussions Week 1-7 All Posts 535 Pages

    OpenAIRE

    Laynebaril1

    2017-01-01

    HOSP 320 Discussions Week 1-7 All Posts 535 Pages   Click Link Below To Buy: http://hwcampus.com/shop/hosp-320-discussions-week-1-7-posts-535-pages/   Or Visit www.hwcampus.com  . HOSP 320 Hotels vs. Motels and Lodging Segments Discussions Week 1 All Posts 77 Pages . HOSP 320 Hotels vs. Motels Discussions 1 Week 1 All Posts 40 Pages . Describe a hotel company with which you are familiar. What are its strengths and weaknesses? What reasons would you decide t...

  15. General Design Memorandum, Gulfport Harbor, Mississippi. Design Memorandum Number 1. Appendix F. Regional Impact and Financial Analysis

    Science.gov (United States)

    1990-03-01

    of restaurants, hotels , and motels, and the Harrison County Tourism Commission Tax, a one percent tax on the gross proceeds from room rentals of all... hotels and motels in Harrison County. These special taxes are assessed in addition to all other taxes imposed. There is also a state use tax, which is...Flows: Tonnage by Commodity Inbound and outbound tonnage for fiscal year (FY) 1986 through FY 1989 are shown in Table 11-10 and in figures 11-4 and 11-5

  16. Simultaneous quantification of salivary 3-hydroxybutyrate, 3-hydroxyisobutyrate, 3-hydroxy-3-methylbutyrate, and 2-hydroxybutyrate as possible markers of amino acid and fatty acid catabolic pathways by LC–ESI–MS/MS

    National Research Council Canada - National Science Library

    Miyazaki, Teruo; Honda, Akira; Ikegami, Tadashi; Iwamoto, Junichi; Monma, Tadakuni; Hirayama, Takeshi; Saito, Yoshifumi; Yamashita, Kouwa; Matsuzaki, Yasushi

    2015-01-01

    ...), 3-hydroxyisobutyrate (3HIB), 3-hydroxy-3-methylbutyrate (3HMB) and 2-hydroxybutyrate (2HB), which could be new non-invasive biomarkers for catabolic pathways of fatty acids/ketogenic amino acids, valine, leucine, and methionine/threonine/α...

  17. Control of fuel target implosion non-uniformity in heavy ion inertial fusion

    CERN Document Server

    Iinuma, T; Kondo, S; Kubo, T; Kato, H; Suzuki, T; Kawata, S; Ogoyski, A I

    2016-01-01

    In inertial fusion, one of scientific issues is to reduce an implosion non-uniformity of a spherical fuel target. The implosion non-uniformity is caused by several factors, including the driver beam illumination non-uniformity, the Rayleigh-Taylor instability (RTI) growth, etc. In this paper we propose a new control method to reduce the implosion non-uniformity; the oscillating implosion acceleration dg(t) is created by pulsating and dephasing heavy ion beams (HIBs) in heavy ion inertial fusion (HIF). The dg(t) would reduce the RTI growth effectively. The original concept of the non- uniformity control in inertial fusion was proposed in (Kawata, et al., 1993). In this paper it was found that the pulsating and dephasing HIBs illumination provide successfully the controlled dg(t) and that dg(t) induced by the pulsating HIBs reduces well the implosion non-uniformity. Consequently the pulsating HIBs improve a pellet gain remarkably in HIF.

  18. Your Baby's First Vaccines

    Science.gov (United States)

    ... Link Vaccines & Immunizations Immunization Schedules Your Child's First Vaccines Format: Select one PDF [335 KB] RTF [260 ... child will get one or more of these vaccines today: DTaP Hib Hepatitis B Polio PCV13 Why ...

  19. Kronisk iskaemisk hjerteinsufficiens. Revaskularisering bedrer overlevelsen blandt patienter med hibernating myocardium

    DEFF Research Database (Denmark)

    Holdgaard, Paw Chr; Nielsen, Søren Steen; Wiggers, Henrik;

    2007-01-01

    INTRODUCTION: Patients with ischemic heart failure and reversible dysfunctional myocardium (Hibernating myocardium, HIB) can benefit from revascularization. These patients can be selected with nuclear methods. The purpose of this study was to describe the results of the imaging procedures...... imaging was performed with 99mTc-sestamibi and glucose metabolism was visualized with 18F-fluorodeoxyglucose (18F-FDG) gamma camera PET. Medical records and death certificate were reviewed retrospectively. RESULTS: 50 patients were included. We found an increased survival among patients with HIB who...... in patients tested for HIB and relate the results to the choice of treatment and cause of death. MATERIALS AND METHODS: During a 2-year period 51 patients were referred to determine the amount of HIB. This can be determined with blood flow and metabolic imaging of the heart. Resting-myocardial perfusion...

  20. Non-Type B Haemophilus Influenzae Meningitis: A Case Report

    Directory of Open Access Journals (Sweden)

    Fatma Deniz Aygun

    2016-02-01

    Full Text Available Haemophilus influenza is one of the most common cause of bacterial meningitis in children. H.influenzae, especially type b (Hib serotype causes invasive infections in children under five years of age. The widespread use of Hib conjugate vaccines has led to a dramatic decline in the incidence of invasive Hib infections. But, the invasive diseases are still reported, particularly nontypeable H. influenzae (noncapsulated remain as an important pathogen. However, there is no evidence that nontypeable H. influenzae infections have increased in frequency. Nontypeable H. Ižnfluenzae serotype is encountered as a cause of acute bacterial meningitis among all ages. In this paper, we present to draw attention to the causative bacterium, in a case of bacterial meningitis caused by nontypeable H. influenzae infection in a child immunized with Hib vaccine.

  1. Vaccinaties in het eerste levensjaar en gerapporteerde allergische aandoeningen bij kinderen van 8-12 jaar

    NARCIS (Netherlands)

    Bernsen, R M D; Jongste, Johan C de; Koes, B W; Aardoom, H A; Wouden, J C van der

    2006-01-01

    Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and allergic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication. Further the Haemophilus influenzae type b (Hib) vaccination was added

  2. Top 9 Ways to Reduce the Risk of Pneumonia If You or a Loved One Is Hospitalized

    Science.gov (United States)

    ... the immune system, or who live in a nursing home or other long-term care facility. Other vaccines that can help prevent diseases that cause pneumonia are Haemophilus influenzae type b vaccine (Hib), pertussis, ...

  3. One Family's Struggles with Rotavirus

    Science.gov (United States)

    ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  4. One Family's Struggle with Chickenpox

    Science.gov (United States)

    ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  5. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  6. One Family's Struggles with Pertussis (Whooping Cough)

    Science.gov (United States)

    ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  7. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  8. One Family's Struggles with Hepatitis B

    Science.gov (United States)

    ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  9. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  10. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  11. One Family's Struggles with HPV (Human Papillomavirus)

    Science.gov (United States)

    ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  12. One Family's Struggles with Hepatitis B

    Medline Plus

    Full Text Available ... the herd dr. offit's testimony not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus ...

  13. One Family's Struggles with Hepatitis B

    Medline Plus

    Full Text Available ... not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room ...

  14. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room ...

  15. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room ...

  16. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room ...

  17. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... not vaccinating the abcs of mmr & dtp thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room ...

  18. Travelers' Health: Immunocompromised Travelers

    Science.gov (United States)

    ... 12 months after a successful transplant, regardless of vaccination history; at least 4 weeks should separate doses. 7 ... supplemental doses for splenectomized patients with incomplete Hib vaccination histories. PCV13 vaccine is recommended for asplenic patients and ...

  19. Citation relations of theories of human information behaviour

    National Research Council Canada - National Science Library

    Hamid R. Jamali

    2013-01-01

    Interrelation of models and theories of human information behaviour (HIB), their common roots, and the extent to which they are indebted to the fields other than library and information science (LIS) were investigated...

  20. Citation relations of theories of human information behaviour

    National Research Council Canada - National Science Library

    Hamid R Jamali

    2013-01-01

      Interrelation of models and theories of human information behaviour (HIB), their common roots, and the extent to which they are indebted to the fields other than library and information science (LIS) were investigated...

  1. The Pattern of Pediatric Respiratory Illnesses Admitted in Ebonyi ...

    African Journals Online (AJOL)

    Microbiology, Ebonyi State University, 3Department of Pediatrics, Federal Medical Centre, Abakaliki, Ebonyi State, Nigeria. Abstract ... infections, but not viral, except antibody studies of the ..... [26] Haemophilus Influenza type B (Hib) vaccine.

  2. ORIGINAL ARTICLES

    African Journals Online (AJOL)

    2000-08-06

    Aug 6, 2000 ... mixing diphtheria-tetanus pertussis-hepatitis B vaccine (DTP-. HBV) and lyophilised Haemophilus injluenzae type B (Hib)- tetanus conjugate vaccines in the same syringe, compared with the same ..... Pediatrics 1981;.

  3. Five-year antibody persistence and safety following a booster dose of combined Haemophilus influenzae type b-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine.

    Science.gov (United States)

    Tejedor, Juan Carlos; Merino, José Manuel; Moro, Manuel; Navarro, Maria-Luisa; Espín, José; Omeñaca, Félix; García-Sicilia, José; Moreno-Pérez, David; Ruiz-Contreras, Jesús; Centeno, Fernando; Barrio, Francisco; Cabanillas, Lucia; Muro, Marta; Esporrin, Carlos; De Torres, Maria Jose; Caubet, Magalie; Boutriau, Dominique; Miller, Jacqueline M; Mesaros, Narcisa

    2012-10-01

    Booster vaccination with the combined Haemophilus influenza type b-Neisseria meningitides serogroup C-tetanus toxoid vaccine (Hib-MenC-TT) has been reported to induce different MenC antibody responses depending on the priming vaccines, with a possible impact on long-term protection. Here, the five-year persistence of immune responses induced by a booster dose of Hib-MenC-TT was evaluated in toddlers primed with either Hib-MenC-TT or MenC-TT. This is the follow-up of a phase III, open, randomized study, in which a Hib-MenC-TT booster dose was given at 13.14 months of age to toddlers primed with either 3 doses of Hib-MenC-TT or 2 doses of MenC-TT in infancy. Children in the control group had received 3 primary doses and a booster dose of MenC-CRM197. Functional antibodies against MenC were measured by a serum bactericidal assay with rabbit complement (rSBA-MenC) and antibodies against Hib polyribosylribitol phosphate by enzyme-linked immunosorbent assay. Serious adverse events considered by the investigator to be possibly related to vaccination were to be reported throughout the study. At 66 months postbooster, rSBA-MenC titers ≥8 were retained by 82.6% of children primed with Hib-MenC-TT, 94.1% of children primed with MenC-TT, and 60.9% of children in the control group. All children who received the Hib-MenC-TT booster dose retained anti- polyribosylribitol phosphate concentrations ≥0.15 μg/mL. No serious adverse events considered possibly related to vaccination were reported. There is evidence of good antibody persistence against MenC and Hib for more than five years postbooster vaccination with Hib-MenC TT in toddlers primed with Hib-MenC-TT or MenC-TT.

  4. Not so simple: the multidimensional nature and diverse origins of political ideology.

    Science.gov (United States)

    Feldman, Stanley; Huddy, Leonie

    2014-06-01

    At odds with Hibbing et al., we argue that political ideology is best explained by at least two dimensions linked to economic and social ideology. In addition, Hibbing et al's claim that conservatism is grounded in a heightened sensitivity to negative outcomes, something closely tied to the personality trait of neuroticism, does not fit with the established personality correlates of political ideology. Conscientiousness and a lack of openness to experience are linked to conservatism but there is no established connection to neuroticism.

  5. Process development of a New Haemophilus influenzae type b conjugate vaccine and the use of mathematical modeling to identify process optimization possibilities.

    Science.gov (United States)

    Hamidi, Ahd; Kreeftenberg, Hans; V D Pol, Leo; Ghimire, Saroj; V D Wielen, Luuk A M; Ottens, Marcel

    2016-05-01

    Vaccination is one of the most successful public health interventions being a cost-effective tool in preventing deaths among young children. The earliest vaccines were developed following empirical methods, creating vaccines by trial and error. New process development tools, for example mathematical modeling, as well as new regulatory initiatives requiring better understanding of both the product and the process are being applied to well-characterized biopharmaceuticals (for example recombinant proteins). The vaccine industry is still running behind in comparison to these industries. A production process for a new Haemophilus influenzae type b (Hib) conjugate vaccine, including related quality control (QC) tests, was developed and transferred to a number of emerging vaccine manufacturers. This contributed to a sustainable global supply of affordable Hib conjugate vaccines, as illustrated by the market launch of the first Hib vaccine based on this technology in 2007 and concomitant price reduction of Hib vaccines. This paper describes the development approach followed for this Hib conjugate vaccine as well as the mathematical modeling tool applied recently in order to indicate options for further improvements of the initial Hib process. The strategy followed during the process development of this Hib conjugate vaccine was a targeted and integrated approach based on prior knowledge and experience with similar products using multi-disciplinary expertise. Mathematical modeling was used to develop a predictive model for the initial Hib process (the 'baseline' model) as well as an 'optimized' model, by proposing a number of process changes which could lead to further reduction in price. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:568-580, 2016.

  6. Comparison of a Multiplex Flow Cytometric Assay with Enzyme-Linked Immunosorbent Assay for Quantitation of Antibodies to Tetanus, Diphtheria, and Haemophilus influenzae Type b

    OpenAIRE

    Pickering, Jerry W.; Martins, Thomas B.; Schroder, M. Carl; Hill, Harry R.

    2002-01-01

    We developed a multiplexed indirect immunofluorescence assay for antibodies to Haemophilus influenza type b (Hib) polysaccharide and the toxoids of Clostridium tetani (Tet) and Corynebacterium diphtheriae (Dip) based on the Luminex multiple-analyte profiling system. A pooled serum standard was calibrated against World Health Organization standards for Dip and Tet and an international standard for Hib. The multiplexed Luminex assay was compared to individual enzyme-linked immunosorbent assays ...

  7. Vaccine-preventable haemophilus influenza type B disease burden and cost-effectiveness of infant vaccination in Indonesia.

    Science.gov (United States)

    Gessner, Bradford D; Sedyaningsih, Endang R; Griffiths, Ulla K; Sutanto, Agustinus; Linehan, Mary; Mercer, Dave; Mulholland, Edward Kim; Walker, Damian G; Steinhoff, Mark; Nadjib, Mardiati

    2008-05-01

    Most of Asia, including Indonesia, does not use Haemophilus influenzae type b (Hib) conjugate vaccines. We estimated total vaccine-preventable disease burden and the cost-effectiveness of Hib conjugate vaccine in Indonesia. Hib pneumonia and meningitis incidences for children with access to health care were derived from a randomized vaccine probe study on Lombok Island, Indonesia during 1998-2002. Incidences were adjusted for limited access to care. Health system and patient out-of-pocket treatment cost data were collected concurrent with the probe study. For Hib vaccine in monovalent and combined (with DTP-HepB) presentations, we used 2007 UNICEF vaccine prices of US$3.30 and $3.75 per dose. For the 2007 Indonesian birth cohort, Hib vaccine would prevent meningitis in 1 of every 179 children, pneumonia in 1 of every 18 children, and 4.9% of mortality among those younger than 5 years. The total incremental societal costs of introducing Hib vaccine in monovalent and pentavalent presentations were, respectively, US$11.74 and $8.93 per child vaccinated. Annual discounted treatment costs averted amounted to 20% of pentavalent vaccine costs. For the pentavalent vaccine, the incremental costs per discounted death and disability adjusted life-year averted amounted to US$3102 and $74, respectively, versus $4438 and $102 for monovalent vaccine. Routine infant Hib vaccination would prevent a large burden of pediatric illness and death in Indonesia. Even without external funding support, Hib vaccine will be a highly cost-effective intervention in either a monovalent or pentavalent presentation based on commonly used benchmarks.

  8. Separation of attractors in 1-modulus quantum corrected special geometry

    CERN Document Server

    Bellucci, S; Marrani, A; Shcherbakov, A

    2008-01-01

    We study the solutions to the N=2, d=4 Attractor Equations in a dyonic, extremal, static, spherically symmetric and asymptotically flat black hole background, in the simplest case of perturbative quantum corrected cubic Special Kahler geometry consistent with continuous axion-shift symmetry, namely in the 1-modulus Special Kahler geometry described (in a suitable special symplectic coordinate) by the holomorphic Kahler gauge-invariant prepotential F=t^3+i*lambda, with lambda real. By performing computations in the ``magnetic'' charge configuration, we find evidence for interesting phenomena (absent in the classical limit of vanishing lambda). Namely, for a certain range of the quantum parameter lambda we find a ``splitting'' of attractors, i.e. the existence of multiple solutions to the Attractor Equations for fixed supporting charge configuration. This corresponds to the existence of ``area codes'' in the radial evolution of the scalar t, determined by the various disconnected regions of the moduli space, wh...

  9. Inflation and Integrable one-field Cosmologies embedded in Rheonomic Supergravity

    CERN Document Server

    Fre, P

    2013-01-01

    In this paper we show that the new approach to the embedding of the inflationary potentials into supergravity, presented in a quite recent paper [11] of Ferrara, Kallosh, Linde and Porrati can be formulated within the framework of standard matter coupled supergravity, without the use of the new minimal auxiliary set and of conformal compensators. The only condition is the existence of a translational Peccei Quinn isometry of the scalar Kahler manifold. We suggest that this embedding strategy based on a nilpotent gauging amounts to a profound Copernican Revolution. The properties of the inflaton potential are encoded in the geometry of some homogeneous one-dimensional Kahler manifolds that now should be regarded as the primary object, possibly providing a link with microscopic physics. We present a simple and elegant formula for the curvature of the Kahler manifold in terms of the potential. Most relevant consequence of the new strategy is that all the integrable potentials quite recently classified in a paper...

  10. Review of Heavy-Ion Inertial Fusion Physics

    CERN Document Server

    Kawata1, S; Ogoyski, A I

    2015-01-01

    In this review paper on heavy ion inertial fusion (HIF), the state-of-the-art scientific results are presented and discussed on the HIF physics, including physics of the heavy ion beam (HIB) transport in a fusion reactor, the HIBs-ion illumination on a direct-drive fuel target, the fuel target physics, the uniformity of the HIF target implosion, the smoothing mechanisms of the target implosion non- uniformity and the robust target implosion. The HIB has remarkable preferable features to release the fusion energy in inertial fusion: in particle accelerators HIBs are generated with a high driver efficiency of ~ 30-40%, and the HIB ions deposit their energy inside of materials. Therefore, a requirement for the fusion target energy gain is relatively low, that would be ~50-70 to operate a HIF fusion reactor with the standard energy output of 1GW of electricity. The HIF reactor operation frequency would be ~10~15 Hz or so. Several- MJ HIBs illuminate a fusion fuel target, and the fuel target is imploded to about a...

  11. Prevention and control of haemophilus influenzae type b disease: recommendations of the advisory committee on immunization practices (ACIP).

    Science.gov (United States)

    Briere, Elizabeth C; Rubin, Lorry; Moro, Pedro L; Cohn, Amanda; Clark, Thomas; Messonnier, Nancy

    2014-02-28

    This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of Haemophilus influenzae type b (Hib) disease in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations; it is intended for use by clinicians, public health officials, vaccination providers, and immunization program personnel as a resource. ACIP recommends routine vaccination with a licensed conjugate Hib vaccine for infants aged 2 through 6 months (2 or 3 doses, depending on vaccine product) with a booster dose at age 12 through 15 months. ACIP also recommends vaccination for certain persons at increased risk for Hib disease (i.e., persons who have early component complement deficiencies, immunoglobulin deficiency, anatomic or functional asplenia, or HIV infection; recipients of hematopoietic stem cell transplant; and recipients of chemotherapy or radiation therapy for malignant neoplasms). This report summarizes current information on Hib epidemiology in the United States and describes Hib vaccines licensed for use in the United States. Guidelines for antimicrobial chemoprophylaxis of contacts of persons with Hib disease also are provided.

  12. Opposite effects of actively and passively acquired immunity to the carrier on responses of human infants to a Haemophilus influenzae type b conjugate vaccine

    DEFF Research Database (Denmark)

    Barington, T; Gyhrs, A; Kristensen, Kim

    1994-01-01

    factors influencing the antibody response to conjugate vaccines are needed. In this study, the response to HibCP coupled to tetanus toxoid (TT) was examined in relation to (i) priming with or coadministration of the carrier protein and (ii) the levels of passively acquired maternal TT antibodies. One...... than infants with low prevaccination levels after the first (P = 0.0001) and the second (P = 0.01) doses of HibCP-TT. In contrast, active priming with TT at 4 months resulted in a threefold-higher median level of anti-HibCP (group C; 1.34 micrograms/ml) than in the unprimed group (group A; 0.......40 microgram/ml) after the first dose of HibCP-TT (P = 0.01). Coadministration of TT had no enhancing effect (group B; 0.58 microgram/ml). No significant differences between the median anti-HibCP levels were seen after the second HibCP-TT dose (6.72, 9.63, and 11.44 micrograms/ml in groups A, B, and C...

  13. Development and technology transfer of Haemophilus influenzae type b conjugate vaccines for developing countries.

    Science.gov (United States)

    Beurret, Michel; Hamidi, Ahd; Kreeftenberg, Hans

    2012-07-13

    This paper describes the development of a Haemophilus influenzae type b (Hib) conjugate vaccine at the National Institute for Public Health and the Environment/Netherlands Vaccine Institute (RIVM/NVI, Bilthoven, The Netherlands), and the subsequent transfer of its production process to manufacturers in developing countries. In 1998, at the outset of the project, the majority of the world's children were not immunized against Hib because of the high price and limited supply of the conjugate vaccines, due partly to the fact that local manufacturers in developing countries did not master the Hib conjugate production technology. To address this problem, the RIVM/NVI has developed a robust Hib conjugate vaccine production process based on a proven model, and transferred this technology to several partners in India, Indonesia, Korea and China. As a result, emerging manufacturers in developing countries acquired modern technologies previously unavailable to them. This has in turn facilitated their approach to producing other conjugate vaccines. As an additional spin-off from the project, a World Health Organization (WHO) Hib quality control (QC) course was designed and conducted at the RIVM/NVI, resulting in an increased regulatory capacity for conjugate vaccines in developing countries at the National Regulatory Authority (NRA) level. For the local populations, this has translated into an increased and sustainable supply of affordable Hib conjugate-containing combination vaccines. During the course of this project, developing countries have demonstrated their ability to produce large quantities of high-quality modern vaccines after a successful transfer of the technology.

  14. b型流感嗜血杆菌结合疫苗接种反应及其处理%Adverse reactions after inoculation of Haemophilus influenzae type b conjugate vaccine and their treatment principles

    Institute of Scientific and Technical Information of China (English)

    樊永贞

    2014-01-01

    Haemophilus influenzae type b (Hib) conjugate vaccine belongs to category Ⅱ vaccine in China.Safety of Hib vaccine is good,and incidence rate of adverse reactions after Hib vaccination is low.Normal reactions after Hib vaccination include local redness,swelling and pain,and mild fever,etc.These symptoms can disappear spontaneously without treatment.Abnormal reactions after Hib vaccination include local blisters and suppuration,systemic allergic rashes and purpura,gastrointestinal reactions,and emotional abnormality,etc.These abnormal reactions can be recovered well after proper treatment.%b型流感嗜血杆菌(Haemophilus in fluenzae type b,Hib)疫苗在中国属于二类疫苗,其安全性良好,接种反应发生率低.Hib疫苗接种后的一般反应包括局部红肿、疼痛,低热等,无需处理可自愈.Hib疫苗接种后的异常反应包括局部水泡和化脓、全身过敏性皮疹和紫癜、消化道反应、情绪异常等,这些异常反应经对症治疗可得到恢复.

  15. Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y tetanus toxoid conjugate vaccine for infants and toddlers.

    Science.gov (United States)

    Bryant, Kristina A; Marshall, Gary S

    2011-07-01

    The highest rates of invasive meningococcal disease occur in children under 2 years of age, yet as of early 2011 no vaccine was licensed for the youngest infants. However, a novel vaccine consisting of capsular polysaccharides from Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroups C and Y conjugated to tetanus toxoid (HibMenCY-TT; MenHibrix, GlaxoSmithKline) is in the late stages of development. In clinical trials involving more than 7800 children, HibMenCY-TT was shown to be safe and immunogenic when administered at 2, 4, 6 and 12-15 months of age. Anti-polyribosylribitol phosphate antibody responses were noninferior to those elicited by licensed monovalent Hib vaccines, and most vaccinees developed bactericidal antibodies against N. meningitidis serogroups C and Y. The majority of subjects retained antibody responses as far as 3 years after vaccination. If licensed, HibMenCY-TT not only represents an incremental option for protection against invasive Hib, but also has the potential to prevent invasive meningococcal disease without increasing the number of injections.

  16. A population-based survey of Haemophilus influenzae type b nasopharyngeal carriage prevalence in Lombok Island, Indonesia.

    Science.gov (United States)

    Gessner, B D; Sutanto, A; Steinhoff, M; Soewignjo, S; Widjaya, A; Nelson, C; Arjoso, S

    1998-09-01

    The Haemophilus influenzae type b (Hib) nasopharyngeal carriage prevalence and invasive disease incidence rates are unknown in Indonesia; consequently Hib vaccine is not included in the routine vaccine schedule. To determine carriage prevalence we conducted a population-based, island-wide prospective study of a systematic sample of 484 children 0 to 2 years of age in Lombok, Indonesia. We conducted a risk factor questionnaire and determined serotypes and antibiotic sensitivity patterns. We identified 155 H. influenzae isolates, of which 22 were type b and 12 were encapsulated but not type b. The age- and population-weighted Hib carriage prevalence, adjusted for the sampling design, was 4.6% (95% confidence interval, 3.7 to 5.5%). Children younger than 6 months of age had a carriage prevalence less than one-half that of older children, and carriage varied within the four administrative regions of the island; otherwise no risk factors for Hib carriage were identified. All Hib specimens were sensitive to ampicillin and 20 (91%) were sensitive to chloramphenicol. The Hib carriage prevalence in Lombok is similar to that found in developed countries before vaccine introduction. This suggests that further studies should proceed to determine whether Lombok has invasive disease rates as high as those that justified vaccine introduction in developed countries.

  17. Re-evaluations of Neutron Induced Nuclear Data for 58Ni

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Yue

    2015-01-01

    Ni is an important structural nuclide.The abundance of 58Ni is 68.077%.There still exist some problems in CENDL-3.1 58Ni evaluations,hence 141Ce should be re-evaluated.Optical motel potential parameters in CENDL-3.1adopted,all the neutron-induced cross sections,energy spectra and angular distributions

  18. Impact of the Energy Crisis on Corps of Engineers Recreation Program.

    Science.gov (United States)

    1981-08-01

    These components include food away from home, hotel and motel charges, gasoline, fares on common carriers, recreational fervices, and incidentals...effects additional gasoline costs would have on future travel plans. Both Converse (1080) and Peine, Marans, and Narris �) have summarized most of this

  19. 48 CFR 22.1003-4 - Administrative limitations, variations, tolerances, and exemptions.

    Science.gov (United States)

    2010-10-01

    ... application of micro-electronic circuitry or other technology of at least similar sophistication is an..., purchase cards, smart cards, and similar card services). (iii) Hotel/motel services for conferences... to price or cost, with the combination of other factors at least as important as price or cost; or (B...

  20. 75 FR 20541 - Homeless Emergency Assistance and Rapid Transition to Housing: Defining “Homeless”

    Science.gov (United States)

    2010-04-20

    ... a hotel ] or a motel, or (3) is no longer being allowed to stay by the owner or renter of housing... information technology, e.g., permitting electronic submission of responses. Interested persons are invited to... either imposes substantial direct compliance costs on State and local governments and is not required by...

  1. 29 CFR 4.123 - Administrative limitations, variances, tolerances, and exemptions.

    Science.gov (United States)

    2010-07-01

    ... who will not observe such standards, and whose saving in labor cost therefrom enables them to offer a... microelectronic circuitry or other technology of at least similar sophistication is an essential element (for... services); (C) Contracts with hotels/motels for conferences, including lodging and/or meals which are part...

  2. 76 FR 1559 - Guidelines for the Use of Electronic Voting Systems in Union Officer Elections

    Science.gov (United States)

    2011-01-11

    ... stations, terminals, or kiosks that are set up in a securable location or locations. Voters must come to a... democratic self-government.'' Wirtz v. Hotel, Motel and Club Employees Union, Local 6, 391 U.S. 492 (1969... guidelines? 2. Describe the potential advantages and disadvantages of electronic voting systems in union...

  3. 75 FR 39135 - Voluntary Public Access and Habitat Incentive Program

    Science.gov (United States)

    2010-07-08

    ... satisfaction from these opportunities. The benefits will be where landowners permit access. VPA-HIP benefits... sales, and increased restaurant and motel expenditures. VPA-HIP is expected to provide $50 million, the... should show how customers will be identified, key personnel to be involved with administration of the...

  4. Profieldiepten van personenautobanden in Nederland : bevindingen bij een aantal metingen in November 1976.

    NARCIS (Netherlands)

    Schlösser, L.H.M. Blokpoel, A. & Harris, S.

    1979-01-01

    The Institute for Road Safety Research SWOV carried out an inspection of the tyres of approximately 6000 cars in the Netherlands during November 1976 in order to measure their tread-depths. The sample was taken at the parking lots of roadside restaurants, motels, and modern shopping centres and sho

  5. 75 FR 68719 - Endangered and Threatened Wildlife and Plants; Emergency Rule To Establish a Manatee Refuge in...

    Science.gov (United States)

    2010-11-09

    ... activities. These activities are an important source of income for the area. Local eco-tour operators, dive shops, marinas, hotels and motels, restaurants, and other businesses benefit from these activities... including on-water volunteer efforts to educate manatee viewers, improved coordination with local...

  6. 29 CFR 779.301 - Statutory provisions.

    Science.gov (United States)

    2010-07-01

    ... resale and is recognized as retail sales or services in the particular industry. (2) Section 13(a)(4... establishment in the particular industry notwithstanding that such establishment makes or processes at the... described in section 3(s), or (ii) Is in such an enterprise and is a hotel, motel or restaurant, or motion...

  7. 22 CFR Appendix E to Part 62 - Unskilled Occupations

    Science.gov (United States)

    2010-04-01

    ... Operators (21) Floorworkers (22) Groundskeepers (23) Guards (24) Helpers, any industry (25) Hotel Cleaners... Cleaners (10) Chauffeurs and Taxicab Drivers (11) Cleaners, Hotel and Motel (12) Clerks, General (13) Clerks, Hotel (14) Clerks and Checkers, Grocery Stores (15) Clerk Typist (16) Cooks, Short Order (17...

  8. Careers Canada, Volume 9: Careers in the Hospitality Industry.

    Science.gov (United States)

    Department of Manpower and Immigration, Ottawa (Ontario).

    This booklet, designed for prospective job seekers, describes occupational opportunities within the food service, food preparation and hotel/motel industries in Canada. The preparatory training and job descriptions of cooks, chefs, tourist guides, waiters, hotel and restaurant managers, bartenders and front desk clerks are highlighted.…

  9. Information System Training, Usage, and Satisfaction: An Exploratory Study of the Hospitality Industry.

    Science.gov (United States)

    Gardner, William L., III; Gundersen, David E.

    1995-01-01

    Discusses use of a mail survey to study the extent to which the hospitality industry employs various information technologies, including computer-mediated communication systems. Finds that hotel/motel size and chain affiliation are related to information system complexity, and that chain-affiliated hotels provide less computer and…

  10. National Communications System: Ensuring Essential Communications for the Homeland

    Science.gov (United States)

    2002-01-01

    small businesses and PBXs operated by the hospitality industry (hotels and motels). Commonly encountered problems include the need to deposit coins...industry groups, such as the American Public Communications Council and hospitality industry organizations and associations, to raise awareness of GETS

  11. Interjöör kuningliku tõlla ja isemängiva kitarriga / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2006-01-01

    Tallinnas Rävala pst. 7 asuva kaupluse "Motel Paradise" sisekujundus. Autorid: Hannes Praks ja Margus Tammik, OÜ Kohvi. H. Praksist ja M. Tammikust, nende tähtsamad tööd. Ill.: kaks korruste plaani, 20 värv. vaadet, fotod sisearhitektidest

  12. Summaries of Conclusions and Recommendations on Department of Defense Operations.

    Science.gov (United States)

    1983-03-04

    feiiiyfo w es mercial buildings as hotels and motels that have been dategnte exanio flexibility for twopibeds. Status: Action in...33) 19 ing (LCD80-9) 91 Mangement of DOD’s Shelf-Life (MASAD-82-5) 122 Establishing Goals for and Subcon- Program--Better, but Still in Need of

  13. 41 CFR 301-11.12 - How does the type of lodging I select affect my reimbursement?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How does the type of... Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES... lodgings. (Hotel/motel, boarding house, etc.) You will be reimbursed the single occupancy rate. (b...

  14. 41 CFR 301-11.15 - What expenses may be considered part of the daily lodging cost when I rent on a long-term basis?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What expenses may be... Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL... the price of a hotel/motel room in the area concerned, the cost of special user fees (e.g., cable TV...

  15. 41 CFR 301-50.8 - Are there any limits on travel arrangements I may make?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Are there any limits on travel arrangements I may make? 301-50.8 Section 301-50.8 Public Contracts and Property Management... Hotel and Motel Fire Safety Act of 1990 (the Act), as amended (see 5 U.S.C. 5707a). (2) When selecting a...

  16. 29 CFR 452.40 - Prior office holding.

    Science.gov (United States)

    2010-07-01

    ... Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS GENERAL STATEMENT CONCERNING THE ELECTION PROVISIONS OF THE LABOR-MANAGEMENT REPORTING AND.... 26 26 Wirtz v. Hotel, Motel and Club Employees Union, Local 6, 391 U.S. 492 at 504. The Court stated...

  17. 77 FR 39731 - Swinomish Indian Tribal Community-Title 15, Chapter 4: Liquor Legalization, Regulation and...

    Science.gov (United States)

    2012-07-05

    .... International Exporter Endorsement 500. Motel 500. Nonprofit Arts Organization 250. Private Club--Beer and Wine 180. Private Club--Spirits, Beer and Wine 720. Non-Club Event Endorsement 900. Public House 1,000.... Sports/Entertainment Facility 2,500. Caterer's Endorsement 350. Tavern--No Persons Under 21 Allowed...

  18. 16 CFR 429.0 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... place of business of the seller (e.g., sales at the buyer's residence or at facilities rented on a temporary or short-term basis, such as hotel or motel rooms, convention centers, fairgrounds and restaurants... retail business establishment having a fixed permanent location where the goods are exhibited or the...

  19. 7 CFR Appendix I to Subpart E of... - Instructions for Loan Guarantees for Drought and Disaster Relief

    Science.gov (United States)

    2010-01-01

    .... Ineligible loan purposes. See § 1980.412. Except for hotels, motels, tourist and recreation facilities... Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE... Business and Industrial Loan Program Pt. 1980, Subpt. E, App. I Appendix I to Subpart E of Part 1980...

  20. 75 FR 63103 - Federal Travel Regulation (FTR); Lodging and Transportation Amendment

    Science.gov (United States)

    2010-10-14

    ... 44 U.S.C. 3501, et seq. E. Small Business Regulatory Enforcement Fairness Act This final rule is also...) You should always stay in a ``fire safe'' facility. This is a facility that meets the fire safety requirements of the Hotel and Motel Fire Safety Act of 1990 (the Act), as amended (see 5 U.S.C. 5707a). (c...

  1. 75 FR 79863 - Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... address teams and joint ventures of small businesses and the requirement that each federal agency must... for teaming and joint ventures involving small businesses. Timetable: Action Date FR Cite NPRM 01/00... (NAICS) Sector 72, Accommodation and Food Services -- namely NAICS 721110, Hotels and Motels, from $7.0...

  2. Small Business Administration Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... address teams and joint ventures of small businesses and the requirement that each federal agency must... for teaming and joint ventures involving small businesses. Timetable: Action Date FR Cite NPRM 01/00... (NAICS) Sector 72, Accommodation and Food Services -- namely NAICS 721110, Hotels and Motels, from $7.0...

  3. 26 CFR 1.856-3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... provisions), then, even if the REMIC satisfies the 95-percent test of paragraph (b)(i) of this section, the... motel, hotel, or office building, etc., even though such items may be termed fixtures under local law... partnership holds any property primarily for sale to customers in the ordinary course of its trade or...

  4. Interjöör kuningliku tõlla ja isemängiva kitarriga / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2006-01-01

    Tallinnas Rävala pst. 7 asuva kaupluse "Motel Paradise" sisekujundus. Autorid: Hannes Praks ja Margus Tammik, OÜ Kohvi. H. Praksist ja M. Tammikust, nende tähtsamad tööd. Ill.: kaks korruste plaani, 20 värv. vaadet, fotod sisearhitektidest

  5. Your Travel Dollar. Money Management.

    Science.gov (United States)

    Baran, Nancy H., Ed.

    This illustrated guide was designed to familiarize consumers with planning a vacation trip, whether domestic or abroad. The guide covers setting up a budget; package tours; cruises and charter flights; travel agencies and clubs; and arranging stays in hotels/motels, rental condominiums, bed-and-breakfasts, hostels, campsites, and private…

  6. 75 FR 78734 - R & M Sales Company, Inc.; Revocation of Registration

    Science.gov (United States)

    2010-12-16

    ... pop type,'' and be found in motels, homes, or trunks of automobiles; the toxic fumes they emit also create a health hazard for children who are exposed to them. Id. \\4\\ According to data compiled by the... chemical products by Respondent. Tr. 121; GX 14. According to this document, Respondent burned...

  7. Report of the Technical Committee for Hospitality, Tourism, Recreation.

    Science.gov (United States)

    Oregon State Dept. of Education, Salem. Div. of Vocational Education.

    This color-coded committee report identifies the skills and knowledge required by employees in the hospitality/tourism/recreation occupational area. The reports of four subcommittees focused on food/beverage, hotel/motel, recreation/leisure, and travel/tourism skills are also included. Introductory materials include a general statement of the…

  8. 75 FR 31895 - National Emission Standards for Hazardous Air Pollutants for Area Sources: Industrial, Commercial...

    Science.gov (United States)

    2010-06-04

    ... establishments such as stores/malls, laundries, apartments, restaurants, and hotels/motels. The institutional... thermal energy in the form of steam or hot water. C. What is the relationship between this proposed rule... have a designed heat input capacity of 10 million British thermal units per hour (MMBtu/h) or...

  9. Decentralized State/Federal Level Emergency Evacuation Management Centers

    Science.gov (United States)

    1982-08-01

    management centers would assume responsihility for activities and coordination not provided by norma ; government or private organizations. They would operate...relocation ,s to no’ se the 3-6 ’I relocatees in public congregate care facilities (e.g., schools, churches, hotels , motels), rather than in private

  10. On the Moduli Space of non-BPS Attractors for N=2 Symmetric Manifolds

    CERN Document Server

    Ferrara, Sergio

    2007-01-01

    We study the ``flat'' directions of non-BPS extremal black hole attractors for N=2, d=4 supergravities whose vector multiplets' scalar manifold is endowed with homogeneous symmetric special Kahler geometry. The non-BPS attractors with non-vanishing central charge have a moduli space described by real special geometry (and thus related to the d=5 parent theory), whereas the moduli spaces of non-BPS attractors with vanishing central charge are certain Kahler homogeneous symmetric manifolds. The moduli spaces of the non-BPS attractors of the corresponding N=2, d=5 theories are also indicated, and shown to be rank-1 homogeneous symmetric manifolds.

  11. On four-derivative terms in IIB Calabi-Yau orientifold reductions

    CERN Document Server

    Weissenbacher, Matthias

    2016-01-01

    We perform a Kaluza-Klein reduction of IIB supergravity including purely gravitational $\\alpha '^3$-corrections on a Calabi-Yau threefold, and perform the orientifold projection accounting for the presence of $O3/O7$-planes. We consider infinitesimal K\\"{a}hler deformations of the Calabi-Yau background and derive the complete set of four-derivative couplings quadratic in these fluctuations coupled to gravity. In particular, we find four-derivative couplings of the K\\"{a}hler moduli fields in the four-dimensional effective supergravity theory, which are referred to as friction couplings in the context of inflation.

  12. On de Sitter vacua in type IIA orientifold compactifications

    Energy Technology Data Exchange (ETDEWEB)

    Saueressig, Frank [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, 3508 TD Utrecht (Netherlands)]. E-mail: f.s.saueressig@phys.uu.nl; Theis, Ulrich [Institute for Theoretical Physics, Friedrich-Schiller-University Jena, Max-Wien-Platz 1, D-07743 Jena (Germany)]. E-mail: ulrich.theis@uni-jena.de; Vandoren, Stefan [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, 3508 TD Utrecht (Netherlands)]. E-mail: s.vandoren@phys.uu.nl

    2006-02-02

    This Letter discusses the orientifold projection of the quantum corrections to type IIA strings compactified on rigid Calabi-Yau threefolds. It is shown that N=2 membrane instanton effects give a holomorphic contribution to the superpotential, while the perturbative corrections enter into the Kahler potential. At the level of the scalar potential the corrections to the Kahler potential give rise to a positive energy contribution similar to adding anti-D3-branes in the KKLT scenario. This provides a natural mechanism to lift an AdS vacuum to a meta-stable dS vacuum.

  13. Searching for a Connection Between Matroid Theory and String Theory

    CERN Document Server

    Nieto, J A

    2004-01-01

    We make a number of observations about matter-ghost string phase, which may eventually lead to a formal connection between matroid theory and string theory. In particular, in order to take advantage of the already established connection between matroid theory and Chern-Simons theory, we propose a generalization of string theory in terms of some kind of Kahler metric. We show that this generalization is closely related to the Kahler-Chern-Simons action due to Nair and Schiff. We also add new information about the relationship between matroid theory, D=11 supergravity and Chern-Simons formalism.

  14. Clinical and economic impact of a combination Haemophilus influenzae and Hepatitis B vaccine: estimating cost-effectiveness using decision analysis.

    Science.gov (United States)

    Fendrick, A M; Lee, J H; LaBarge, C; Glick, H A

    1999-02-01

    Compliance with hepatitis B virus (HBV) vaccine remains suboptimal, despite a recommendation by the Advisory Committee on Immunization Practices of the US Public Health Service that all newborns be vaccinated. Although a combined HBV-Haemophilus influenzae type b (Hib) vaccine may improve acceptance of the HBV vaccine, the clinical and economic consequences of this intervention are uncertain. To compare the health impact and cost-effectiveness of the following 2 immunization strategies: current practice of administering HBV vaccine separately (75% compliance) and Hib vaccine alone or as part of a multivalent vaccine (95% compliance); and strategy of delivering a combined HBV-Hib vaccine (95% compliance). A Markov model simulated the natural history of acute and chronic HBV and Hib disease in a cohort of US newborns. Clinical and economic variables were obtained from published reports. The Hib-related outcomes were the same in both strategies, because the efficacy and compliance with Hib vaccine were assumed to be equivalent in both. A 53% reduction in the number of cases of HBV infection with the combination strategy (n = 8541) was estimated when compared with current practice (n = 18 044), along with 205 fewer HBV-related deaths per 1 million infants. Immunization costs of the combination strategy were $11.5 million higher than for current practice ($108.4 million compared with $96.9 million), whereas the cost of HBV-related disease was $4.0 million lower than in current practice. The incremental cost-effectiveness ratio for the combination strategy was $17700 per year of life saved. An HBV-Hib vaccine in US infants yields substantial benefits, with a cost-effectiveness ratio that is lower than that of many commonly used medical interventions.

  15. Interchangeability of Quinvaxem during primary vaccination schedules: results from a phase IV, single-blind, randomized, controlled, single-center, non-inferiority study.

    Science.gov (United States)

    Capeding, Maria Rosario Z; Jica, Corina; Macura-Biegun, Anna; Rauscher, Martina; Alberto, Edison

    2014-02-07

    Combination vaccines against diphtheria, tetanus and pertussis (DTP) represent the core of childhood vaccination programs. Quinvaxem, a fully-liquid, pentavalent combination vaccine containing inactivated hepatitis B (HepB), Haemophilus influenzae type b (Hib) and whole-cell pertussis (wP) antigens, and tetanus and diphtheria toxoids, has been shown to be suitable for boosting children primed in infancy with another DTwP-HepB-Hib vaccine. This single-blind, randomized, controlled study was designed to demonstrate non-inferiority of a primary vaccination course (6-10-14 week schedule) of Tritanrix HB+Hib (first dose) and Quinvaxem (second/third doses) versus three doses of Quinvaxem with respect to the seroprotection/seroconversion rates for all antigens one month after vaccination course completion. Four hundred healthy subjects eligible for the local Expanded Program on Immunization were enrolled and equally randomized to the two treatment regimens. All subjects achieved seroprotection for tetanus and Hib, all except one for diphtheria, and all except two achieved seroconversion against Bordetella pertussis. Seroprotection against hepatitis B was achieved by 97.4% of Tritanrix HB+Hib followed by Quinvaxem and 94.9% of Quinvaxem subjects. Therefore, one month after vaccination course completion, seroprotection rates (seroconversion rate for B. pertussis) of Tritanrix HB+Hib followed by Quinvaxem were non-inferior to those elicited by Quinvaxem only, thus meeting the primary objective. Adverse events were comparable between the groups and were in line with the safety profile of the vaccines. The switch of vaccine had no apparent effect on safety endpoints. Our results support the use of Quinvaxem interchangeably with Tritanrix HB+Hib in a primary vaccination course and provides further evidence for the interchangeability of pentavalent vaccines (Clinical Trials.gov registry: NCT01357720). Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Comparative economic evaluation of Haemophilus influenzae type b vaccination in Belarus and Uzbekistan.

    Directory of Open Access Journals (Sweden)

    Ulla K Griffiths

    Full Text Available BACKGROUND: Hib vaccine has gradually been introduced into more and more countries during the past two decades, partly due to GAVI Alliance support to low-income countries. However, since Hib disease burden is difficult to establish in settings with limited diagnostic capacities and since the vaccine continues to be relatively expensive, some Governments remain doubtful about its value leading to concerns about financial sustainability. Similarly, several middle-income countries have not introduced the vaccine. The aim of this study is to estimate and compare the cost-effectiveness of Hib vaccination in a country relying on self-financing (Belarus and a country eligible for GAVI Alliance support (Uzbekistan. METHODS AND FINDINGS: A decision analytic model was used to estimate morbidity and mortality from Hib meningitis, Hib pneumonia and other types of Hib disease with and without the vaccine. Treatment costs were attached to each disease event. Data on disease incidence, case fatality ratios and costs were primarily determined from national sources. For the Belarus 2009 birth cohort, Hib vaccine is estimated to prevent 467 invasive disease cases, 4 cases of meningitis sequelae, and 3 deaths, while in Uzbekistan 3,069 invasive cases, 34 sequelae cases and 341 deaths are prevented. Estimated costs per discounted DALY averted are US$ 9,323 in Belarus and US$ 267 in Uzbekistan. CONCLUSION: The primary reason why the cost-effectiveness values are more favourable in Uzbekistan than in Belarus is that relatively more deaths are averted in Uzbekistan due to higher baseline mortality burden. Two other explanations are that the vaccine price is lower in Uzbekistan and that Uzbekistan uses a three dose schedule compared to four doses in Belarus. However, when seen in the context of the relative ability to pay for public health, the vaccine can be considered cost-effective in both countries.

  17. Synthesis of the building block 2-hydroxyisobutyrate from fructose and butyrate by Cupriavidus necator H16.

    Science.gov (United States)

    Przybylski, Denise; Rohwerder, Thore; Harms, Hauke; Yaneva, Nadya; Müller, Roland H

    2013-10-01

    2-Hydroxyisobutyryl-coenzyme A mutase, originally discovered in the context of methyl tert-butyl ether degradation in Aquincola tertiaricarbonis L108, catalyzes the isomerization of 3-hydroxybutyryl-coenzyme A (3-HB-CoA) to 2-hydroxyisobutyryl-CoA. It thus constitutes the basis for a biotechnological route from practically any renewable carbon to 2-hydroxyisobutyrate (2-HIB) via the common metabolite 3-hydroxybutyrate. At first sight, recombinant Cupriavidus necator H16 expressing the mutase seems to be well suited for such a synthesis process, as a strong overflow metabolism via (R)-3-HB-CoA is easily induced in this bacterium possessing the poly-3-hydroxybutyrate metabolism. However, the recently established stereospecificity of the mutase, dominantly preferring the (S)-enantiomer of 3-HB-CoA, calls for a closer investigation of C. necator as potential 2-HIB production strain and raised the question about the strain's potential to yield 2-HIB from substrates directly providing (S)-3-HB-CoA. We compared two mutase-expressing C. necator H16 strains for their capability to synthesize 2-HIB from fructose and butyrate, delivering either (R)- or (S)-3-HB-CoA. Our results indicate that due to the enantiospecificity of the mutase, fructose is a weaker substrate for 2-HIB synthesis than butyrate. Production rates achieved with the PHB-negative strain H16 PHB(-)4 on butyrate were higher than on fructose. Using the wild-type did not significantly improve the production rates as the latter showed a 34-fold and a 5-fold lower 2-HIB synthesis rate compared to H16 PHB(-)4 on fructose and butyrate, respectively. Moreover, both strains showed concomitant excretion of undesired side products, such as pyruvate and 3-hydroxybutyrate, significantly decreasing the 2-HIB yield.

  18. DNA aptamers for the detection of Haemophilus influenzae type b by cell SELEX.

    Science.gov (United States)

    Bitaraf, F S; Rasooli, I; Mousavi Gargari, S L

    2016-03-01

    Haemophilus influenzae type b (Hib) causes acute bacterial meningitis (ABM) in children, with a mortality rate of about 3-6 % of the affected patients. ABM can lead to death during a period of hours to several days and, hence, rapid and early detection of the infection is crucial. Aptamers, the short single-stranded DNA or RNA with high affinity to target molecules, are selected by a high-flux screening technique known as in vitro screening and systematic evolution of ligands by exponential enrichment technology (SELEX). In this study, whole-cell SELEX was applied for the selection of target-specific aptamers with high affinity to Hib. ssDNA aptamers prepared by lambda exonuclease were incubated with the target cells (Hib). The aptameric binding rate to Hib was characterized for binding affinity after seven SELEX rounds by flow cytometry. The aptamers with higher binding affinity were cloned. Four of 68 aptamer clones were selected for sequencing. The dissociation constant (Kd) of the high-affinity aptamer clones 45 and 63 were 47.10 and 28.46 pM, respectively. These aptamers did not bind to other bacterial species, including the seven meningitis-causing bacteria. They showed distinct affinity to various H. influenzae strains only. These aptamers showed the highest affinity to Hib and the lowest affinity to H. influenzae type c and to other meningitis-causing bacteria. Clone 63 could detect Hib in patients' cerebrospinal fluid (CSF) samples at 60 colony-forming units (CFU)/mL. The results indicate applicability of the aptamers for rapid and early detection of infections brought about by Hib.

  19. Twistors and Black Holes

    CERN Document Server

    Neitzke, A; Vandoren, S; Neitzke, Andrew; Pioline, Boris; Vandoren, Stefan

    2007-01-01

    Motivated by black hole physics in N=2, D=4 supergravity, we study the geometry of quaternionic-Kahler manifolds M obtained by the c-map construction from projective special Kahler manifolds M_s. Improving on earlier treatments, we compute the Kahler potentials on the twistor space Z and Swann space S in the complex coordinates adapted to the Heisenberg symmetries. The results bear a simple relation to the Hesse potential \\Sigma of the special Kahler manifold M_s, and hence to the Bekenstein-Hawking entropy for BPS black holes. We explicitly construct the ``covariant c-map'' and the ``twistor map'', which relate real coordinates on M x CP^1 (resp. M x R^4/Z_2) to complex coordinates on Z (resp. S). As applications, we solve for the general BPS geodesic motion on M, and provide explicit integral formulae for the quaternionic Penrose transform relating elements of H^1(Z,O(-k)) to massless fields on M annihilated by first or second order differential operators. Finally, we compute the exact radial wave function ...

  20. Complex geometry and real geometry

    Institute of Scientific and Technical Information of China (English)

    YU; Yanlin; ZHU; Lin; FENG; Xiuhong

    2005-01-01

    There is a well-known way to generalize the Riemann-Roch operator for Kahler manifold to that for Hermitian manifold. In this paper we show a slightly different way to get a generalized Riemann-Roch operator, which is just the Dirac operator. The difference between the two operators is that the latter one enables the so-called Pythagoras equalities.

  1. Supersymmetric Sigma Model Geometry

    OpenAIRE

    Ulf Lindström

    2012-01-01

    This is a review of how sigma models formulated in Superspace have become important tools for understanding geometry. Topics included are: The (hyper)k\\"ahler reduction; projective superspace; the generalized Legendre construction; generalized K\\"ahler geometry and constructions of hyperk\\"ahler metrics on Hermitean symmetric spaces.

  2. Holomorphic Cartan geometries, Calabi--Yau manifolds and rational curves

    CERN Document Server

    Biswas, Indranil; 10.1016/j.difgeo.2009.09.003

    2010-01-01

    We prove that if a Calabi--Yau manifold $M$ admits a holomorphic Cartan geometry, then $M$ is covered by a complex torus. This is done by establishing the Bogomolov inequality for semistable sheaves on compact K\\"ahler manifolds. We also classify all holomorphic Cartan geometries on rationally connected complex projective manifolds.

  3. Homogeneous spaces, multi-moment maps and (2,3)-trivial algebras

    DEFF Research Database (Denmark)

    Madsen, T. B.; Swann, A.

    2011-01-01

    For geometries with a closed three-form we briefly overview the notion of multi-moment maps. We then give concrete examples of multi-moment maps for homogeneous hypercomplex and nearly Kahler manifolds. A special role in the theory is played by Lie algebras with second and third Betti numbers equal...

  4. YⅢ的完备Einstein-K(a)hler度量与Bergman度量的等价性%The Equivalence of the Complete Einstein-K(a)hler Metric and the Bergman Metric on YⅢ

    Institute of Scientific and Technical Information of China (English)

    王贵霞

    2007-01-01

    In this paper we give the proof about the equivalence of the complete EinsteinKahler metric and the Bergman metric on Cartan-Hartogs domain of the third type.And we obtain the method of getting the equivalence of two metrics.

  5. A Note on Fluxes in Six-Dimensional String Theory Backgrounds

    CERN Document Server

    Becker, K; Becker, Katrin; Tseng, Li-Sheng

    2004-01-01

    We study the structure of warped compactifications of type IIB string theory to six space-time dimensions. We find that the most general four-manifold describing the internal dimensions is conformal to a Kahler manifold, in contrast with the heterotic case where the four-manifold must be conformally Calabi-Yau.

  6. Moduli Stabilization Using Open String Fluxes

    Science.gov (United States)

    Kumar, Alok

    2007-04-01

    In this talk we discuss how by turning on gauge fluxes which couple to the end-points of open strings one can obtain stabilization of closed string moduli. This is done by analyzing supersymmetry constraints and RR tadpole conditions. Stabilization of complex and Kahler moduli is studied in a T6/Z2 orientifold. REFID="9789812770523_0020FN001">.

  7. Supersymmetric Sigma Model geometry

    CERN Document Server

    Lindström, Ulf

    2012-01-01

    This is a review of how sigma models formulated in Superspace have become important tools for understanding geometry. Topics included are: The (hyper)k\\"ahler reduction; projective superspace; the generalized Legendre construction; generalized K\\"ahler geometry and constructions of hyperk\\"ahler metrics on Hermitean symmetric spaces.

  8. Implementing Hilltop F-term Hybrid Inflation in Supergravity

    CERN Document Server

    Armillis, R

    2012-01-01

    F-term hybrid inflation (FHI) of the hilltop type can generate a scalar spectral index, ns, in agreement with the fitting of the seven-year Wilkinson microwave anisotropy probe data by the standard power-law cosmological model with cold dark matter and a cosmological constant, LambdaCDM. We investigate the realization of this type of FHI by using quasi-canonical Kahler potentials with or without the inclusion of extra hidden-sector fields. In the first case, acceptable results can be obtained by constraining the coefficients of the quadratic and/or quartic supergravity correction to the inflationary potential and therefore a mild tuning of the relevant term of the Kahler potential is unavoidable. Possible reduction of ns without generating maxima and minima of the potential on the inflationary path is also possible in a limited region of the available parameter space. The tuning of the terms of the Kahler potential can be avoided with the adoption of a simple class of string-inspired Kahler potentials for the...

  9. Supergravity couplings: a geometric formulation

    OpenAIRE

    Binetruy, P.; Girardi, G.; Grimm, R

    2000-01-01

    This report provides a pedagogical introduction to the description of the general Poincare supergravity/matter/Yang-Mills couplings using methods of Kahler superspace geometry. At a more advanced level this approach is generalized to include tensor field and Chern-Simons couplings in supersymmetry and supergravity, relevant in the context of weakly and strongly coupled string theories.

  10. Supergravity couplings a geometric formulation

    CERN Document Server

    Binétruy, Pierre; Grimm, R

    2001-01-01

    This report provides a pedagogical introduction to the description of the general Poincare supergravity/matter/Yang-Mills couplings using methods of Kahler superspace geometry. At a more advanced level this approach is generalized to include tensor field and Chern-Simons couplings in supersymmetry and supergravity, relevant in the context of weakly and strongly coupled string theories.

  11. Locally supersymmetric D=3 non-linear sigma models

    NARCIS (Netherlands)

    Wit, B. de; Tollsten, A. K.; Nicolai, H.

    1992-01-01

    We study non-linear sigma models with N local supersymmetries in three space-time dimensions. For N=1 and 2 the target space of these models is Riemannian or Kahler, respectively. All N>2 theories are associated with Einstein spaces. For N=3 the target space is quaternionic, while for N=4 it general

  12. Kähler potentials for Planck inflation

    NARCIS (Netherlands)

    Roest, Diederik; Scalisi, Marco; Zavala Carrasco, Ivonne

    2013-01-01

    We assess which Kahler potentials in supergravity lead to viable single-field inflationary models that are consistent with Planck. We highlight the role of symmetries, such as shift, Heisenberg and supersymmetry, in these constructions. Also the connections to string theory are pointed out. Finally,

  13. Projectively related complex Finsler metrics

    CERN Document Server

    Aldea, Nicoleta

    2011-01-01

    In this paper we introduce in study the projectively related complex Finsler metrics. We prove the complex versions of the Rapcs\\'{a}k's theorem and characterize the weakly K\\"{a}hler and generalized Berwald projectively related complex Finsler metrics. The complex version of Hilbert's Fourth Problem is also pointed out. As an application, the projectiveness of a complex Randers metric is described.

  14. Calabi-Yau metrics and string compactification

    CERN Document Server

    Douglas, Michael R

    2015-01-01

    Yau proved an existence theorem for Ricci-flat K\\"ahler metrics in the 1970's, but we still have no closed form expressions for them. Nevertheless there are several ways to get approximate expressions, both numerical and analytical. We survey some of this work and explain how it can be used to obtain physical predictions from superstring theory.

  15. Polynomial Structure of Topological String Partition Functions

    CERN Document Server

    Zhou, Jie

    2015-01-01

    We review the polynomial structure of the topological string partition functions as solutions to the holomorphic anomaly equations. We also explain the connection between the ring of propagators defined from special K\\"ahler geometry and the ring of almost-holomorphic modular forms defined on modular curves.

  16. 用于Hib结合疫苗生产的新型候选菌株的评价%Evaluation on a new candidate strain for Haemophilus influenzae type b conjugate vaccine production

    Institute of Scientific and Technical Information of China (English)

    王伟; 马雷钧; 王月红; 朱为; 马相虎

    2011-01-01

    目的 观察b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)760705株在连续传代过程中的稳定性.方法 将Hib 760705株工作种子批菌种连续传代,对第5、第8、第10代Hib培养物进行全面检测,包括培养特性(细菌培养、卫星试验)、染色镜检、生化反应,以检测第5、第8、第10代Hib的生物学特性.同时采用血清凝集试验和聚合酶链反应荚膜分型方法进行b型荚膜多糖稳定性检测.结果 Hib 760705株工作种子批培养物在连续传代过程中具有典型的细菌学特性,能够稳定地产生b型荚膜多糖.结论 Hib 760705株有明确的来源和背景,可以稳定传代,具备作为Hib结合疫苗生产用候选菌株的条件.%Objective To observe the passage stability of Haemophilus influenzae type b(Hib) strain 760705. Methods Hib strain 760705 was cultured for 10 passages from the working seed lot, and the subcultures of the 5th, 8th and 10th passages were detected for biological charactristics comprehensively,including cultural characteristics( bacterial culture and satellite test), staining and microscopic examination,and biochemical reactions. Serological agglutination test and polymerase chain reaction for capsular typing were applied to confirm the generation stability of type b capsular polysaccharide. Results The subcultures of Hib strain 760705 had typical bacteriological characteristics and capability of yielding type b capsular polysaccharide. Conclusions Hib strain 760705 has a clear origin and background and can be subcultured stably, thus suggesting that it can be a candidate strain for Hib conjugate vaccine production.

  17. [Invasive infections caused by Haemophilus influenzae type b after the institution of the conjugated vaccine on the expanded programm on immunization in Chile].

    Science.gov (United States)

    Cruces R, Pablo; Donoso F, Alejandro; Camacho A, Jorge; Llorente H, Marcela

    2006-03-01

    After almost a decade since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines in Chile (in a 2-4-6 month schedule), Hib invasive infections have dramatically decreased, albeit they remain to occasionally produce disease in pediatric patients. We report our experience with children whom developed Hib invasive disease in children since 2000 to 2004. Medical records of children with Hib were reviewed in order to describe the epidemiology, main clinical and laboratory findings, management and complications. Twenty three patients (17 male), between 1 and 71 months (median 30 months) were identified: pneumonia (7), meningitis (4), pleuropneumonia (2), empyema (2), sepsis (2), cellulitis (2), meningitis and pleuropneumonia (1), purpura fulminans (1), miositis (1) and epiglottitis (1). No deaths were observed and four patients presented severe sequelae at hospital discharge. Twenty patients were considered vaccine failures. Hib remains as a sporadic cause of severe disease in Chile and thus for physicians should still keep it in mind. Case analysis and active surveillance are necessary to monitor the current immunization regimen.

  18. Comparison of a multiplex flow cytometric assay with enzyme-linked immunosorbent assay for auantitation of antibodies to tetanus, diphtheria, and Haemophilus influenzae Type b.

    Science.gov (United States)

    Pickering, Jerry W; Martins, Thomas B; Schroder, M Carl; Hill, Harry R

    2002-07-01

    We developed a multiplexed indirect immunofluorescence assay for antibodies to Haemophilus influenza type b (Hib) polysaccharide and the toxoids of Clostridium tetani (Tet) and Corynebacterium diphtheriae (Dip) based on the Luminex multiple-analyte profiling system. A pooled serum standard was calibrated against World Health Organization standards for Dip and Tet and an international standard for Hib. The multiplexed Luminex assay was compared to individual enzyme-linked immunosorbent assays (ELISAs) for the same analytes. By both methods, 75 (92.6%) of 81 of random serum samples had protective levels of antibody to Tet (> or = 0.1 IU/ml). For Dip, 81.5% of the samples had protective antibody levels (> or = 0.1 IU/ml) by ELISA and 80.2% had protective antibody levels by Luminex. Protective levels (> or = 1.0 microg/ml) of antibody to Hib were found in 45.0% of the samples tested by ELISA and in 39.0% of the samples tested by Luminex. The correlations (R(2)) between ELISA and Luminex of the 81 samples were 0.96, 0.96, and 0.91 for Tet, Dip, and Hib, respectively. There was also similar agreement between Luminex and ELISA for sera collected before and 1 month after Tet, Dip, and Hib vaccine administration. Both methods detected strong postvaccination responses. The Luminex method is an attractive alternative to ELISA since it reduces labor and reagent costs, as well as assay time.

  19. Genotyping of Haemophilus influenzae type b strains and their incidence in the clinical samples isolated from Iranian patients

    Science.gov (United States)

    Bagherzadeh Khodashahri, Somayeh; Siadat, Seyed Davar; Rahbar, Mohammad; Abdollahpour-Alitappeh, Meghdad; Vaziri, Farzam; Rahnamaye-Farzami, Mrjan; Mohammadzadeh, Mona; Davari, Mehdi; Fateh, Abolfazl; Masoumi, Morteza

    2015-01-01

    Background and Objective: Haemophilus influenzae type b (Hib) is divided into two distinct genotypes, type I and type II, based on the structure of capsular polysaccharides. The capsulation locus of Haemophilus influenzae type b consists of three functionally distinct regions, designated regions 1 to 3. Region III contains hcsA and hcsB genes; however, notable sequence variation in this region can be used to recognize different Hib genotypes. The purpose of this study was to investigate the prevalence and genotype of the Hib strains isolated from patients with invasive disease in Iran. Materials and Methods: In the present study, 8 pairs of primers were used for identification and serotyping of encapsulated Haemophilus influenzae strains, as well as confirmation of species identification. Additionally, in order to identify the capsular genotypes of Haemophilus influenzae type b (type I and II), two additional primer pairs were used to amplify the hcsA gene. Results: Out of 50 isolates of H. influenzae, four were found to be type b. Interestingly, among these 4 Hib isolates, 2 strains belonged to the type-II category. Conclusion: Our study shows that the prevalence of both Hib types I and II seems to be high in Iran. PMID:26668700

  20. An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered with Infanrix™ hexa is immunogenic, with an acceptable safety profile in 12-23-month-old children.

    Science.gov (United States)

    Knuf, Markus; Pantazi-Chatzikonstantinou, Anna; Pfletschinger, Ulrich; Tichmann-Schumann, Irmingard; Maurer, Hartwig; Maurer, Lothar; Fischbach, Thomas; Zinke, Henrike; Pankow-Culot, Heidemarie; Papaevangelou, Vassiliki; Bianco, Veronique; Van der Wielen, Marie; Miller, Jacqueline M

    2011-06-06

    Tetravalent meningococcal serogroups ACWY conjugate vaccines will provide an advantage to those at most risk of invasive meningococcal disease; namely young children. Co-administration of ACWY-TT with DTaP-HBV-IPV/Hib was assessed in a randomized trial in 793 children aged 12-23 months. Pre-specified criteria for non-inferiority of immunogenicity following co-administration versus separate ACWY-TT and DTaP-HBV-IPV/Hib administration were reached. One month post-vaccination, ≥ 97.3% of ACWY-TT vaccinees had rSBA titres ≥ 1:8 (all serogroups). Seroprotection/seropositivity rates against DTaP-HBV-IPV/Hib antigens were ≥ 98.2%. The safety profile of co-administration was similar to that of DTaP-HBV-IPV/Hib alone. ACWY-TT and DTaP-HBV-IPV/Hib co-administration during the second year would facilitate introduction of ACWY-TT into routine toddler vaccination schedules.

  1. Use of Dorset egg medium for maintenance and transport of Neisseria meningitidis and Haemophilus influenzae type b.

    Science.gov (United States)

    Wasas, A D; Huebner, R E; Klugman, K P

    1999-06-01

    Studies of bacterial meningitis are hampered by the inability to maintain the viability of etiological agents during transport to reference laboratories. The long-term survival rate of 20 isolates of Neisseria meningitidis and Haemophilus influenzae type b (Hib) on Dorset egg medium, supplemented Columbia agar base medium, chocolate agar, and Amies medium was compared with that on 70% GC agar (chocolate) transport medium. N. meningitidis isolates were also inoculated onto 5% horse blood agar, and Hib was inoculated onto Haemophilus test medium. All of the N. meningitidis isolates remained viable on Dorset egg medium for 21 days; viability on the other media was poor after only 7 days. Recovery rates of Hib isolates were similar on Dorset egg and Haemophilus test media (100% after 21 days) and significantly better than on the other media. Dorset egg medium is inexpensive and easy to make and may be invaluable for studies of bacterial meningitis in developing countries.

  2. Cloning and sequence analysis of the structural pilin gene of Brazilian purpuric fever-associated Haemophilus influenzae biogroup aegyptius.

    Science.gov (United States)

    Whitney, A M; Farley, M M

    1993-04-01

    We have cloned and sequenced the Brazilian purpuric fever (BPF)-associated Haemophilus influenzae biogroup aegyptius (Hae) pilin gene. The sequence contained a 648-bp open reading frame encoding a mature pilin protein of 191 amino acids with a calculated mass of 20.5 kDa. There was 82% homology between the open reading frames of the BPF strain F3031 and H. influenzae type b (Hib) (strain M43) pilin genes and 71% homology at the amino acid level between the mature pilin proteins. However, areas of diversity were noted throughout the gene. A 17-bp probe corresponding to an area of diversity in the N-terminal region of the BPF-associated gene hybridized with other BPF strains but not with non-BPF Hae or Hib. In summary, the pilin protein of BPF-associated Hae is highly homologous to Hib pilin yet remains structurally distinct.

  3. Quantitation of antibody-secreting cells in the blood after vaccination with Haemophilus influenzae type b conjugate vaccine

    DEFF Research Database (Denmark)

    Barington, T; Heilmann, C; Andersen, V

    1990-01-01

    The human B-lymphocyte response to protein-conjugated polysaccharide antigens has not previously been studied at the cellular level. In order to do so, we developed and evaluated haemolytic plaque-forming cell assays detecting Haemophilus influenzae type b (Hib) capsular polysaccharide-specific a......The human B-lymphocyte response to protein-conjugated polysaccharide antigens has not previously been studied at the cellular level. In order to do so, we developed and evaluated haemolytic plaque-forming cell assays detecting Haemophilus influenzae type b (Hib) capsular polysaccharide...... capsular polysaccharides from Hib and pneumococci. The predominance of IgA AbSC in response to both conjugate and pure polysaccharide vaccines is probably due to reactivation of the same clones of IgA-committed memory B cells originally primed at the mucosa by natural exposure to the polysaccharide...

  4. Rapid analysis of rearranged kappa light chain genes of circulating polysaccharide-specific B lymphocytes by means of immunomagnetic beads and the polymerase chain reaction

    DEFF Research Database (Denmark)

    Hougs, L; Barington, T; Madsen, HO

    1993-01-01

    of the B lymphocytes activated in vivo. Here, we present a method for rapid analysis of the rearranged kappa light chain genes used by human circulating antigen-specific B lymphocytes. After vaccination with Haemophilus influenzae type b capsular polysaccharide (HibCP) conjugated with protein, the Hib......CP-specific B lymphocytes were isolated by antigen-coated immunomagnetic beads. After the purification, at least 98% of the immunoglobulin-secreting recovered cells were HibCP specific. The RNA was isolated and amplified by cDNA synthesis using a kappa constant region primer followed by polymerase chain...... reaction (PCR) using in addition a degenerate kappa light chain signal peptide region primer. The PCR product was cloned into the M13mp18 phage. The cloning efficiency was 100-600 clones/ml of blood. Of the 86 clones sequenced, 90% represented rearranged kappa light chain genes from different antibody...

  5. Rapid analysis of rearranged kappa light chain genes of circulating polysaccharide-specific B lymphocytes by means of immunomagnetic beads and the polymerase chain reaction

    DEFF Research Database (Denmark)

    Hougs, L; Barington, T; Madsen, HO

    1993-01-01

    reaction (PCR) using in addition a degenerate kappa light chain signal peptide region primer. The PCR product was cloned into the M13mp18 phage. The cloning efficiency was 100-600 clones/ml of blood. Of the 86 clones sequenced, 90% represented rearranged kappa light chain genes from different antibody......CP-specific B lymphocytes were isolated by antigen-coated immunomagnetic beads. After the purification, at least 98% of the immunoglobulin-secreting recovered cells were HibCP specific. The RNA was isolated and amplified by cDNA synthesis using a kappa constant region primer followed by polymerase chain...... of the B lymphocytes activated in vivo. Here, we present a method for rapid analysis of the rearranged kappa light chain genes used by human circulating antigen-specific B lymphocytes. After vaccination with Haemophilus influenzae type b capsular polysaccharide (HibCP) conjugated with protein, the Hib...

  6. Pricing strategies for combination pediatric vaccines based on the lowest overall cost formulary.

    Science.gov (United States)

    Behzad, Banafsheh; Jacobson, Sheldon H; Sewell, Edward C

    2012-10-01

    This paper analyzes pricing strategies for US pediatric combination vaccines by comparing the lowest overall cost formularies (i.e., formularies that have the lowest overall cost). Three pharmaceutical companies compete pairwise over the sale of monovalent and combination vaccines. Particular emphasis is placed on examining the price of Sanofi Pasteur's DTaP-IPV/HIb under different conditions. The main contribution of the paper is to provide the lowest overall cost formularies for different prices of DTaP-IPV/HIb and other Sanofi Pasteur vaccines. The resulting analysis shows that DTaP-IPV/HIb could have been more competitively priced compared with the combination vaccine DTaP-HepB-IPV, for federal contract prices in 2009, 2010 and 2011. This study also proposes the lowest overall cost formularies when shortages of monovalent vaccines occur.

  7. 打造中国特色的“汽车旅馆”——莫泰168崛起沪上揭秘

    Institute of Scientific and Technical Information of China (English)

    刘耿大

    2005-01-01

    2004年,由美林阁餐饮集团及大众交通投资的Motell68(莫泰连锁旅店),以8家连锁店的规模,雨后舂笋般在上海经济型酒店市场异军突起,成为一支与锦江之星、如家连琐酒店鼎足而立的经济型酒店劲旅。作为三家中唯一引进国外汽车旅馆(Motel)概念的经济型连锁酒店,莫泰168却又是有着自己特色的中国式“汽车旅馆”。

  8. Haemophilus influenzae tipo b: situação epidemiológica no Estado de Minas Gerais, Brasil, 1993 a 1997 Haemophilus influenzae type b: epidemiological situation in the State of Minas Gerais, Brazil, 1993-1997

    Directory of Open Access Journals (Sweden)

    Sybelle de Souza Castro Miranzi

    2003-10-01

    Full Text Available Entre as doenças invasivas causadas pelo Haemophilus influenzae tipo b (Hib, destacam-se, pela freqüência e gravidade, as pneumonias e as meningites. No período de 1993 a 1997, foram notificados, em Minas Gerais, 720 casos de meningites por Hib, sendo a causa mais freqüente de meningite bacteriana em menores de um ano e a segunda causa no total de meningites. Entretanto, estimou-se uma ocorrência total de 1.160 casos considerando as meningites bacterianas não especificadas. O total de casos estimados de doença invasiva por Hib parece justificar a recente inclusão da vacina no esquema básico de imunizações. O alto custo da vacina reforça a necessidade de melhorar a vigilância epidemiológica da meningite, que constitui uma das fragilidades das ações de controle desta doença.Among Haemophilus influenzae type b (Hib invasive diseases, pneumonia and meningitis are the most relevant in public health due to their frequency and severity. From 1993 to 1997, there were 720 cases of Hib meningitis in Minas Gerais State, Brazil, representing the most frequent cause of bacterial meningitis in infants (< 1 year and the second most frequent among all causes of meningitis. The total estimated cases of invasive Hib diseases thus appear to justify the recent inclusion of the vaccine in the basic immunization protocol. The vaccine's high cost reinforces the need for more precise monitoring of the etiological diagnosis of meningitis cases, representing one of the weaknesses in the prevailing epidemiological surveillance system.

  9. No evidence of increasing Haemophilus influenzae non-b infection in Australian Aboriginal children

    Directory of Open Access Journals (Sweden)

    Robert I. Menzies

    2013-08-01

    Full Text Available Background. High, or increasing, rates of invasive Haemophilus influenzae (Hi type a disease have been reported from North American native children from circumpolar regions, raising the question of serotype replacement being driven by vaccination against Hi type b (Hib. Indigenous Australians from remote areas had high rates of invasive Hib disease in the past, comparable to those in North American Indigenous populations. Objective. Evaluate incidence rates of invasive Hi (overall and by serotype in Indigenous Australian children over time. Design. Descriptive study of Hi incidence rates by serotype, in the Northern Territory (NT and South Australia (SA from 2001 to 2011. Comparison of NT data with a study that was conducted in the NT in 1985–1988, before Hib vaccine was introduced. Results. The average annual rate of invasive Hi type a (Hia disease in Indigenous children aged <5 years was 11/100,000 population. Although the incidence of Hi infection in Indigenous children in 2001–2003 was lower than during 2004–2011, this may be due to changes in surveillance. No other trend over time in individual serotypes or total invasive Hi disease, in Indigenous or non-Indigenous people, was identified. Compared to 1985–1988, rates in 2001–2011 were lower in all serotype groupings, by 98% for Hib, 75% for Hia, 79% for other serotypes and 67% for non-typeable Hi. Conclusions. There is no evidence of increases in invasive disease due to Hia, other specific non-b types, or non-typeable Hi in Australian Indigenous children. These data suggest that the increase in Hia some time after the introduction of Hib vaccine, as seen in the North American Arctic Region, is not common to all populations with high pre-vaccine rates of invasive Hib disease. However, small case numbers and the lack of molecular subtyping and PCR confirmation of pre-vaccine results complicate comparisons with North American epidemiology.

  10. Improvement of Large-scale PRP production by Haemophilus influenzae typeb, using modified CY medium

    Directory of Open Access Journals (Sweden)

    Farshad Nojoomi

    2012-02-01

    Full Text Available Background and Objective: Haemophilus influenzae type b (Hib is a gram negative bacterium and one of the most common causative agents of acute meningitis in infants and less than 5 years old children worldwide. The production of Hib capsular polysaccharide; polyribosyl ribitolphosphate (PRP is important for the production of conjugate vaccines against Hib infections. The aim of this study is the improvement of Large-scale PRP production by Hib. Materials and Methods: Haemophilus influenzae type b standard strain ATCC10211 was cultivated in 2L fermentors contain 1.5L CY (casaminoacid yeast extract medium with normal or modified concentrations of glucose, yeast extract, hemin and NAD (nicotinamide adenine dinucleotide. Seed culture of two fermentors was inoculated to 50 L fermentor, separately and range of PRP production and Dry cell weight (DCW were studied. Results: Cultivation of Hib in 50L fermentor contained modified CY medium with 6gl-1 Glucose, 2.5 gl-1 Yeast extract, 0.03 gl-1 Hemin and 0.015 gl-1 NAD , with controlled pH at 7.3 and 30% Dissolved oxygen tension (DOT resulted to about 5.1 gl-1 DCW and 1.16 gl-1 PRP , that was significantly higher than normal CY medium. Conclusion: In conclusion, by modification in some medium components of CY medium, control of Dissolved oxygen tension and pH, the Large-scale production of PRP is improved. Improvement of PRP production leads to reduce the final cost of Hib conjugate vaccines.

  11. Safety and immunogenocity of a novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups A and C-tetanus-toxoid conjugate vaccine in healthy Chinese children aged 6 months to 5 years old.

    Science.gov (United States)

    Hu, Jian-li; Tao, Hong; Li, Jing-xin; Dai, Wei-ming; Song, Bin; Sun, Jin-fang; Liu, Pei; Tang, Jie; Liu, Wen-yu; Wang, Shi-yuan; Zhu, Feng-cai

    2015-01-01

    A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups A and C-tetanus-toxoid conjugate vaccine (Hib-MenAC vaccine) has been developed to protect children against diseases caused by Hib, MenA, and MenC. This study investigated the safety and immunogenicity of the Hib-MenAC vaccine administered in 2-dose series to children aged 6-23 months and in a single dose to children aged 2-5 y. A randomized, positive-controlled, non-inferiority clinical trial was conducted for 1200 healthy participants in each age group. Within each age group, participants were randomly allocated to the Hib-MenAC group or the control group at a ratio of 1:1. Adverse reactions were recorded within 28 d after each dose. Blood samples were obtained to assess immunogenicity on day 0 and at 28 d after a complete vaccination course. For the investigational vaccine, the incidence of total adverse reactions in vaccinees aged 6-23 months was 46.8% and that in vaccinees aged 2-5 y was 29.8%. Most adverse reactions were mild or moderate. One non-fatal serious adverse event occurred in the Hib-MenAC group, but was unrelated to vaccination. The seroconversion rate to the 3 components reached 94.0%, and the proportion of vaccinees with rSBA titers ≥ 1:8 and PRP ≥ 0.15 g/mL reached 97.0% in both age groups. The safety and immunogenicity of the Hib-MenAC vaccine were non-inferior when compared to the licensed vaccines. It was concluded that the novel vaccine would be expected to protect children against all of the targeted diseases.

  12. The Taxi Driver Found His Long-lost Son(高一适用)

    Institute of Scientific and Technical Information of China (English)

    孙伟玲

    2002-01-01

    A taxi driver has found the son he last saw 34 years ago --as a fare in the back of his cab. The chance of reunion came when Barry Bagshaw, 61,picked up a fare at a motel near Brighton in southern England. A short panying the man in the back found the driver's identity and noticed he had the same surname as her boyfriend.

  13. Investigación de mercado para determinar la viabilidad de comercialización en canales no explorados, de los preservativos Jäger en la ciudad de Santiago de Cali

    OpenAIRE

    Delgado Salazar, Adriana Jineth; Orozco Caicedo, Maritza

    2011-01-01

    El presente trabajo, denominado “Investigación de mercado para determinar la viabilidad de comercialización en canales no explorados, de los preservativos Jäger en la ciudad de Santiago de Cali”, tiene como objetivo determinar la viabilidad de comercialización del producto anteriormente mencionado en los canales desatendidos por el actual distribuidor autorizado para el territorio colombiano (Importadora Megga). Entre dichos canales se encuentran los sitios de diversión nocturna, moteles, tie...

  14. The Organization of Knowledge in a Multi-Lingual, Integrated Parser.

    Science.gov (United States)

    1984-11-01

    from this transformed pare tree. " " - To illustrate the division of labor into these three phases, consider the following . translation: English: The...Jordan was ambushed and shot in the back by an unidentified sniper in a motel parking lot Thursday. Spanish: Vernon Jordan, el lider do los derechos ...banco do Queens hoy. I demando el derecho , do quedarse on los, Estados, Unidos. Final representation: NTRO. CONCEPT MTRANS ACTOR HUM7 0CONCEPT

  15. Final Environmental Assessment/Overseas Environmental Assessment: East Coast Testing of the Tomahawk Land Attack Missile

    Science.gov (United States)

    2004-12-01

    tourist/vacation residences (i.e., hotels , motels, and cottages). Transiting west and crossing the St. Johns River to Starke, the terrain beneath...8217· , . .,.,. · .. 2 .. ~· s~le~ ·~- ~ , ’’)£ • ,"¥!~~; • L • .-c •. 3 ’ • "’ . ,. Scientific ·Name~’:’!:.:. -lt<’if: .co·mmon Narrie ~~:."/ FederaL

  16. Wake-up call

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    A recent roundtable discussion with energy buyers from major national accounts indicated that electric utilities have a long way to go to prove themselves worthy of customer loyalty. All too often standard utility rate and service practices are at odds with customer needs. This article presents comments from meeting attendees from McDonalds, Sears, TJ Maxx, Southland Corporation, Motel 6, and White Castle about customer needs and problems in utility company services and responses.

  17. Subsurface Thermal Energy Storage for Improved Heating and Air Conditioning Efficiency

    Science.gov (United States)

    2016-11-21

    buildings, schools, multi-family apartments, restaurants , retail buildings, motels, hospitals , etc.). Each of these building templates is populated with...imbalance arises from waste heat caused by lighting and other appliances, industrial machinery, communications and computing equipment, and people. Medium...and the air temperature is 70 oF, the heat rejection by the cooler is 404 kBTU/hr or about 34 tons (in the cooling industry , a ton is a unit of

  18. Improving Geothermal Heat Pump Air Conditioning Efficiency with Wintertime Cooling using Seasonal Thermal Energy Storage (STES). Application Manual

    Science.gov (United States)

    2016-11-01

    buildings, schools, multi-family apartments, restaurants , retail buildings, motels, hospitals , etc.). Each of these building templates is populated with...increase energy efficiency and occupant comfort. It suggests industry tools that will assist the EM/FM in doing needed calculations to justify the...cooling. The load imbalance arises from waste heat caused by lighting and other appliances, industrial machinery, communications and computing

  19. Manual for Defense Incident-Based Reporting System,

    Science.gov (United States)

    2011-07-21

    metals bracelets, necklaces, rings, watches, etc., gold, silver, platinum 18 Livestock living farm animals e.g. cattle, chickens , hogs, horses, sheep...Occupancy Dwellings;" e.g., apartments, tenements, temporary living quarters, such as hotels , motels, inns 31 Structures-other commercial stores, office...34 25 NUMBER OF PREMISES ENTERED (Vol. 1, pg. 77) - 2 characters. This data element is to be used only if the crime is Burglary/B&E and the " Hotel

  20. Creech Air Force Base Resort Property in Indian Springs, Nevada. Environmental Baseline Survey Report

    Science.gov (United States)

    2011-04-01

    from the irrigation well system reacted vigorously with the hydrochloric acid (HCl) used to preserve the samples. This reaction to HCl was likely due...United States Post Office and a pizza place/bar. The casino was constru cted in 1984, the motel in 1988, and the Chevron station in 1989. Mr. Becker was...D Fed. Land Use: Wilde mess Areas, Wildlife Preserves .................... . Fed

  1. Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.

    OpenAIRE

    Baldo, V; P. Bonanni; Castro, M.; GABUTTI, G.; Franco, E.; Marchetti, F.; Prato, R.; F. Vitale

    2014-01-01

    Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11–12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age...

  2. Thermo-mechanical characterization of a monochlorophenyl, hepta isobutyl polyhedral oligomeric silsesquioxane/polystyrene composite

    Energy Technology Data Exchange (ETDEWEB)

    Blanco, Ignazio, E-mail: iblanco@dii.unict.it; Bottino, Francesco A., E-mail: iblanco@dii.unict.it; Cicala, Gianluca, E-mail: iblanco@dii.unict.it; Cozzo, Giulia, E-mail: iblanco@dii.unict.it; Latteri, Alberta, E-mail: iblanco@dii.unict.it; Recca, Antonino, E-mail: iblanco@dii.unict.it [Department of Industrial Engineering, University of Catania, Viale A. Doria 6, 95125 Catania (Italy)

    2014-05-15

    The thermal and mechanical properties of a monochlorophenyl, hepta isobutyl Polyhedral Oligomeric Silsesquioxane/Polystyrene (ph,hib-POSS/PS) composite were studied and compared with those of pristine polymer. ph,hib-POSS/PS system was prepared by solubilization and precipitation of Polystyrene (PS) in the presence of POSS. Scanning Electron Microscopy (SEM) was performed to check the distribution of the filler in the polymer matrix. Dynamic Mechanical Analysis (DMA) was carried out to measure viscoelastic properties of solid samples. Degradations were carried out into a thermobalance and the obtained thermogravimetric (TG) and differential thermogravimetric (DTG) curves were discussed and interpreted.

  3. First-principles study on molecular dissociation under metallization pressure in aromatic monomolecular crystals with iodine atoms

    CERN Document Server

    Tateyama, Y

    2002-01-01

    We have examined the metallization mechanism and possibility of molecular dissociation in iodanil (IA) and hexa-iodobenzene (HIB) under pressure by using first-principles calculations. We found that the metallization in IA is caused by the band overlap in the molecular phase and dissociation does not follow the metallization. In HIB, on the other hand, the band overlap mechanism is found to be less probable, which implies that a structural transformation will occur before the metallization. Both mechanisms are completely different from that for I sub 2 diatomic molecular crystal, and suggest essential roles of C sub 6 rings and O atoms.

  4. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2

    DEFF Research Database (Denmark)

    Hougs, L; Juul, L; Ditzel, H J

    1999-01-01

    selected, and expanded population of cells existing before vaccination, i.e., memory B cells. The dominating heavy and light chains of the response were combined in a Fab that bound HibCP. It was shown that the shared heavy and light chain mutations increased the affinity for HibCP considerably, indicating...... that the clonal selection had been driven by affinity. Pre-existing memory cells in unvaccinated adults may explain several features of Ab responses to polysaccharide vaccines and may play a role in acquiring the ability to respond to pure polysaccharides during infancy....

  5. Analysis of non-typeable Haemophilus influenzae in invasive disease reveals lack of the capsule locus.

    Science.gov (United States)

    Lâm, T-T; Claus, H; Frosch, M; Vogel, U

    2016-01-01

    Among invasive Haemophilus influenzae, unencapsulated strains have largely surpassed the previously predominant serotype b (Hib) because of Hib vaccination. Isolates without the genomic capsule (cap) locus are designated non-typeable H. influenzae (NTHi). They are different from capsule-deficient variants that show deletion of the capsule transport gene bexA within the cap locus. The frequency of capsule-deficient variants in invasive disease is unknown. We analysed 783 unencapsulated invasive isolates collected over 5 years in Germany and found no single capsule-deficient isolate. Invasive unencapsulated strains in Germany were exclusively NTHi. A negative serotyping result by slide agglutination was therefore highly predictive for NTHi.

  6. Thermo-mechanical characterization of a monochlorophenyl, hepta isobutyl polyhedral oligomeric silsesquioxane/polystyrene composite

    Science.gov (United States)

    Blanco, Ignazio; Bottino, Francesco A.; Cicala, Gianluca; Cozzo, Giulia; Latteri, Alberta; Recca, Antonino

    2014-05-01

    The thermal and mechanical properties of a monochlorophenyl, hepta isobutyl Polyhedral Oligomeric Silsesquioxane/Polystyrene (ph,hib-POSS/PS) composite were studied and compared with those of pristine polymer. ph,hib-POSS/PS system was prepared by solubilization and precipitation of Polystyrene (PS) in the presence of POSS. Scanning Electron Microscopy (SEM) was performed to check the distribution of the filler in the polymer matrix. Dynamic Mechanical Analysis (DMA) was carried out to measure viscoelastic properties of solid samples. Degradations were carried out into a thermobalance and the obtained thermogravimetric (TG) and differential thermogravimetric (DTG) curves were discussed and interpreted.

  7. Scale Factor Self-Dual Cosmological Models

    CERN Document Server

    dS, U Camara; Sotkov, G M

    2015-01-01

    We implement a conformal time scale factor duality for Friedmann-Robertson-Walker cosmological models, which is consistent with the weak energy condition. The requirement for self-duality determines the equations of state for a broad class of barotropic fluids. We study the example of a universe filled with two interacting fluids, presenting an accelerated and a decelerated period, with manifest UV/IR duality. The associated self-dual scalar field interaction turns out to coincide with the "radiation-like" modified Chaplygin gas models. We present an equivalent realization of them as gauged K\\"ahler sigma models (minimally coupled to gravity) with very specific and interrelated K\\"ahler- and super-potentials. Their applications in the description of hilltop inflation and also as quintessence models for the late universe are discussed.

  8. Supersymmetric BCS

    CERN Document Server

    Barranco, Alejandro

    2012-01-01

    We implement relativistic BCS superconductivity in N=1 supersymmetric field theories with a U(1)_R symmetry. The simplest model contains two chiral superfields with a Kahler potential modified by quartic terms. We study the phase diagram of the gap as a function of the temperature and the specific heat. The superconducting phase transition turns out to be first order, due to the scalar contribution to the one-loop potential. By virtue of supersymmetry, the critical curves depend logarithmically with the UV cutoff, rather than quadratically as in standard BCS theory. We comment on the difficulties in having fermion condensates when the chemical potential is instead coupled to a baryonic U(1)_B current. We also discuss supersymmetric models of BCS with canonical Kahler potential constructed by "integrating-in" chiral superfields.

  9. Towards natural inflation from weakly coupled heterotic string theory

    CERN Document Server

    Abe, Hiroyuki; Otsuka, Hajime

    2014-01-01

    We propose the natural inflation from the heterotic string theory on "Swiss-Cheese" Calabi-Yau manifold with multiple $U(1)$ magnetic fluxes. Such multiple $U(1)$ magnetic fluxes stabilize the same number of the linear combination of the universal axion and K\\"ahler axions and one of the K\\"ahler axions is identified as the inflaton. This axion decay constant can be determined by the size of one-loop corrections to the gauge kinetic function of the hidden gauge groups, which leads effectively to the trans-Planckian axion decay constant consistent with the WMAP, Planck and/or BICEP2 data. During the inflation, the real parts of the moduli are also stabilized by employing the nature of the "Swiss-Cheese" Calabi-Yau manifold.

  10. Numerical Ricci-flat metrics on K3

    CERN Document Server

    Headrick, M; Headrick, Matthew; Wiseman, Toby

    2005-01-01

    We develop numerical algorithms for solving the Einstein equation on Calabi-Yau manifolds at arbitrary values of their complex structure and Kahler parameters. We show that Kahler geometry can be exploited for significant gains in computational efficiency. As a proof of principle, we apply our methods to a one-parameter family of K3 surfaces constructed as blow-ups of the T^4/Z_2 orbifold with many discrete symmetries. High-resolution metrics may be obtained on a time scale of days using a desktop computer. We compute various geometric and spectral quantities from our numerical metrics. Using similar resources we expect our methods to practically extend to Calabi-Yau three-folds with a high degree of discrete symmetry, although we expect the general three-fold to remain a challenge due to memory requirements.

  11. A symplectic rearrangement of the four dimensional non-geometric scalar potential

    CERN Document Server

    Shukla, Pramod

    2015-01-01

    We present a symplectic rearrangement of the effective four-dimensional non-geometric scalar potential resulting from the type IIB superstring compactification on Calabi Yau orientifolds. The strategy has two main steps. In the first step, we rewrite the four dimensional scalar potential utilizing some interesting flux combinations which we call {\\it new generalized flux orbits}. After invoking a couple of non-trivial symplectic relations, in the second step, we further rearrange all the pieces of scalar potential into a completely `symplectic-formulation' which involves only the symplectic ingredients (such as period matrix etc.) without the need of knowing Calabi Yau metric. Moreover, the scalar potential under consideration is induced by a generic tree level K\\"{a}hler potential and (non-geometric) flux superpotential for arbitrary numbers of complex structure moduli, K\\"ahler moduli and odd-axions. Finally, we exemplify our symplectic formulation for the two well known toroidal examples based on type IIB ...

  12. Lower bound of the tensor-to-scalar ratio r≳0.1 in a nearly quadratic chaotic inflation model in supergravity

    Directory of Open Access Journals (Sweden)

    Keisuke Harigaya

    2015-02-01

    Full Text Available We consider an initial condition problem in a nearly quadratic chaotic inflation model in supergravity. We introduce shift symmetry breaking not only in the superpotential but also in the Kahler potential. In this model the inflaton potential is nearly quadratic for inflaton field values around the Planck scale, but deviates from the quadratic one for larger field values. As a result, the prediction on the tensor-to-scalar ratio can be smaller than that of a purely quadratic model. Due to the shift symmetry breaking in the Kahler potential, the inflaton potential becomes steep for large inflaton field values, which may prevent inflation from naturally taking place in a closed universe. We estimate an upper bound on the magnitude of the shift symmetry breaking so that inflation takes place before a closed universe with a Planck length size collapses, which yields a lower bound on the tensor-to-scalar ratio, r≳0.1.

  13. The topology of asymptotically locally flat gravitational instantons

    Energy Technology Data Exchange (ETDEWEB)

    Etesi, Gabor [Department of Geometry, Mathematical Institute, Faculty of Science, Budapest University of Technology and Economics, Egry J. u. 1 H ep., H-1111 Budapest (Hungary)]. E-mail: etesi@math.bme.hu

    2006-10-26

    In this Letter we demonstrate that the intersection form of the Hausel-Hunsicker-Mazzeo compactification of a four-dimensional ALF gravitational instanton is definite and diagonalizable over the integers if one of the Kahler forms of the hyper-Kahler gravitational instanton metric is exact. This leads to their topological classification. The proof exploits the relationship between L{sup 2} cohomology and U(1) anti-instantons over gravitational instantons recognized by Hitchin. We then interprete these as reducible points in a singular SU(2) anti-instanton moduli space over the compactification leading to the identification of its intersection form. This observation on the intersection form might be a useful tool in the full geometric classification of various asymptotically locally flat gravitational instantons.

  14. Heavy Tails in Calabi-Yau Moduli Spaces

    CERN Document Server

    Long, Cody; McGuirk, Paul

    2014-01-01

    We study the statistics of the metric on K\\"ahler moduli space in compactifications of string theory on Calabi-Yau hypersurfaces in toric varieties. We find striking hierarchies in the eigenvalues of the metric and of the Riemann curvature contribution to the Hessian matrix: both spectra display heavy tails. The curvature contribution to the Hessian is non-positive, suggesting a reduced probability of metastability compared to cases in which the derivatives of the K\\"ahler potential are uncorrelated. To facilitate our analysis, we have developed a novel triangulation algorithm that allows efficient study of hypersurfaces with $h^{1,1}$ as large as 25, which is difficult using algorithms internal to packages such as Sage. Our results serve as input for statistical studies of the vacuum structure in flux compactifications, and of the distribution of axion decay constants in string theory.

  15. De Sitter vacua in no-scale supergravities and Calabi-Yau string models

    CERN Document Server

    Covi, Laura; Gross, Christian; Louis, Jan; Palma, Gonzalo A; Scrucca, Claudio A

    2008-01-01

    We perform a general analysis on the possibility of obtaining metastable vacua with spontaneously broken N=1 supersymmetry and non-negative cosmological constant in the moduli sector of string models. More specifically, we study the condition under which the scalar partners of the Goldstino are non-tachyonic, which depends only on the Kahler potential. This condition is not only necessary but also sufficient, in the sense that all of the other scalar fields can be given arbitrarily large positive square masses if the superpotential is suitably tuned. We consider both heterotic and orientifold string compactifications in the large-volume limit and show that the no-scale property shared by these models severely restricts the allowed values for the `sGoldstino' masses in the superpotential parameter space. We find that a positive mass term may be achieved only for certain types of compactifications and specific Goldstino directions. Additionally, we show how subleading corrections to the Kahler potential which b...

  16. The Stability of Fake Flat Domain Walls on Kähler Manifold

    Science.gov (United States)

    Akbar, F. T.; Wijaya, R. N.; Gunara, B. E.

    2016-08-01

    In this paper, we study the stability of flat fake domain walls solution of fake N = 1 supergravity in d + 1 dimensions with Kahler surface as the sigma model. We start with Lagrangian for N = 1 fake supergravity which is coupling between gravity and complex scalar in d + 1 dimensions with scalar potential turned on. Then, as in supergravity theory, we demand that the scalar fields span the Kahler manifold. The equations of motion for fields can be reduced into first order equations by defining the superpotential and the resulting equations are called the projection equation and the fake BPS equation. Finally, we discuss about the stability of flat fake domain walls by investigating the critical points of the superpotential and the scalar potential.

  17. Response to vaccination in patients immunocompromised due to asplenia, allogeneic stem cell transplantation or chemotherapy

    NARCIS (Netherlands)

    Meerveld-Eggink, A.

    2010-01-01

    Asplenic individuals are at increased risk for fulminant infections, especially with encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib) and Neisseria meningitidis, and vaccination is indicated. An inventory was made of the awareness of the infectious risks an

  18. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  19. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  20. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  1. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  2. Meningitis

    Science.gov (United States)

    ... West Nile virus : This virus is spread by mosquito bites and has become a cause of viral ... testing. Other tests that may be done include: Blood culture Chest ... vaccines can help prevent some types of bacterial meningitis: Haemophilus vaccine ( HiB vaccine ) given ...

  3. Oral Polio Vaccination and Hospital Admissions With Non-Polio Infections in Denmark

    DEFF Research Database (Denmark)

    Sørup, Signe; Stensballe, Lone G; Krause, Tyra G;

    2016-01-01

    with inactivated diphtheria-tetanus-pertussis-polio-Haemophilus influenzae type b vaccine (DTaP-IPV-Hib) or live measles-mumps-rubella vaccine (MMR) as their most recent vaccine. Methods.  A nationwide, register-based, retrospective cohort study of 137 403 Danish children born 1997-1999, who had received 3 doses...

  4. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2

    DEFF Research Database (Denmark)

    Hougs, L; Juul, L; Ditzel, H J

    1999-01-01

    The Ab response of a healthy adult to the first dose of a Haemophilus influenzae type b capsular polysaccharide (HibCP) conjugate vaccine was studied at the level of Ig gene usage by circulating Ab-secreting cells. Forty-one IgA and 17 IgG mRNA sequences were obtained. The major part of the respo......The Ab response of a healthy adult to the first dose of a Haemophilus influenzae type b capsular polysaccharide (HibCP) conjugate vaccine was studied at the level of Ig gene usage by circulating Ab-secreting cells. Forty-one IgA and 17 IgG mRNA sequences were obtained. The major part...... selected, and expanded population of cells existing before vaccination, i.e., memory B cells. The dominating heavy and light chains of the response were combined in a Fab that bound HibCP. It was shown that the shared heavy and light chain mutations increased the affinity for HibCP considerably, indicating...... that the clonal selection had been driven by affinity. Pre-existing memory cells in unvaccinated adults may explain several features of Ab responses to polysaccharide vaccines and may play a role in acquiring the ability to respond to pure polysaccharides during infancy....

  5. Vaccinaties in het eerste levensjaar en gerapporteerde allergische aandoeningen bij kinderen van 8-12 jaar

    NARCIS (Netherlands)

    Bernsen, R M D; Jongste, Johan C de; Koes, B W; Aardoom, H A; Wouden, J C van der

    2006-01-01

    Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and allergic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication. Further the Haemophilus influenzae type b (Hib) vaccination was added r

  6. Explaining ideology: two factors are better than one.

    Science.gov (United States)

    Robbins, Philip; Shields, Kenneth

    2014-06-01

    Hibbing et al. contend that individual differences in political ideology can be substantially accounted for in terms of differences in a single psychological factor, namely, strength of negativity bias. We argue that, given the multidimensional structure of ideology, a better explanation of ideological variation will take into account both individual differences in negativity bias and differences in empathic concern.

  7. Clinical characteristics of Haemophilus influenzae meningitis in Denmark in the post-vaccination era

    DEFF Research Database (Denmark)

    Pedersen, T.I.; Howitz, M.; Andersen, Christian Østergaard

    2010-01-01

    P>The introduction of Haemophilus influenzae type b (Hib) vaccine into the Danish childhood vaccination programme in 1993 may have influenced the epidemiology of H. influenzae meningitis (i.e. increasing frequency of other non-vaccine types; presentation in other age groups). Based on nationwide...

  8. b型流行性感冒嗜血杆菌疫苗的现状及展望%Current Status and Future Development of Haemophilus Influenzae Type b Vaccine

    Institute of Scientific and Technical Information of China (English)

    张雁云

    2011-01-01

    Haemophilus influenzae type b(Hib) infection is a global public health issue, mainly causes pneumonia and meningitis in children, and seriously threaten children's health. The introduction of Hib vaccine has opened up a new path on prevention of infectious disease. This paper review the polyribosylribitel phosphate chain, types of carrier protein and their features, immunogenicity and safety of different Hib conjugated vaccine, and the development of combined vaccine. It will be help for providing practical information to immunization program and clinical practice.%b型流行性感冒嗜血杆菌(Haemophilus Influenzae Type B,Hib)感染,是全球性的公共卫生问题,主要引起儿童肺炎和脑膜炎,严重危害儿童的健康.Hib疫苗的诞生为Hib感染性疾病的预防开辟了一条新的道路.现对Hib结合疫苗的多聚核糖基核糖醇磷酸盐糖链、载体蛋白的种类和特点、不同Hib结合疫苗的免疫原性和安全性,以及联合疫苗的发展作了综述,以期为预防接种和临床操作提供参考.

  9. Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United States

    DEFF Research Database (Denmark)

    Bruun, B; Gahrn-Hansen, B; Westh, H;

    2004-01-01

    Surveillance performed after the introduction of general Haemophilus influenzae serotype b (Hib) vaccination in Denmark identified 13 cases of invasive bacteraemic H. influenzae serotype f (Hif) disease in adults over a period of 7 years. Bacteraemic respiratory tract infections accounted for 61...

  10. Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario

    Directory of Open Access Journals (Sweden)

    Pouya Sadeghi-Aval

    2013-01-01

    Full Text Available Before the introduction of the conjugate vaccine, Haemophilus influenzae serotype b (Hib was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes of H influenzae, such as a (Hia, or f (Hif. The emergence of invasive disease caused by non-Hib in northwestern Ontario (38 cases between 2002 and 2008 with predominance of Hia was previously reported by the authors. At that time, no cases of pediatric meningitis caused by H influenzae were recorded in the region. Continued surveillance identified 12 new cases of invasive non-Hib between January 2009 and July 2011. Among these cases, three young children developed meningitis with severe complications caused by Hia or Hif. The present article describes these cases along with the characteristics of recent H influenzae isolates from the region, (ie, their genetic background and antibiotic sensitivity. The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario.

  11. To tilfaelde af invasive infektioner med Haemophilus influenzae type f

    DEFF Research Database (Denmark)

    Nielsen, Jette Dettmann; Lind, Jens Wentzel; Bruun, Britta;

    2009-01-01

    Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...

  12. Recurrent Posttraumatic Meningitis due to Nontypable Haemophilus influenzae: Case Report and Review of the Literature

    DEFF Research Database (Denmark)

    Kunze, W; Müller, L; Kilian, Mogens;

    2007-01-01

    We report a case of relapsing Haemophilus influenzae meningitis in a boy at the age of nearly 3 years and 4.2 years who had been successfully vaccinated against H. influenzae serotype b (Hib). The pathogen was a nonencapsulated (nontypable) H. influenzae strain of biotypes III and VI, respectively...

  13. Non-epitope-specific suppression of the antibody response to Haemophilus influenzae type b conjugate vaccines by preimmunization with vaccine components

    DEFF Research Database (Denmark)

    Barington, T; Skettrup, M; Juul, L;

    1993-01-01

    Recently, conjugate vaccines containing Haemophilus influenzae type b capsular polysaccharide (HibCP) coupled to protein carriers were introduced for use in infants and certain adult risk groups. Similar conjugate vaccines against other capsulated bacteria are currently under development for both...

  14. Haemophilus influenzae type f meningitis in a previously healthy boy

    DEFF Research Database (Denmark)

    Ronit, Andreas; Berg, Ronan M G; Bruunsgaard, Helle;

    2013-01-01

    Non-serotype b strains of Haemophilus influenzae are extremely rare causes of acute bacterial meningitis in immunocompetent individuals. We report a case of acute bacterial meningitis in a 14-year-old boy, who was previously healthy and had been immunised against H influenzae serotype b (Hib...

  15. [Two cases of invasive Haemophilus influenzae type f infection

    DEFF Research Database (Denmark)

    Nielsen, J.D.; Lind, J.W.; Bruun, B.

    2009-01-01

    Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...

  16. Phenology of Maconellicoccus hirsutus (Green) Hemiptera: Pseudococcidae) in Florida based on attraction of adult males to pheromone traps

    Science.gov (United States)

    Research was conducted in Florida to assess the phenology of pink hibiscus mealybug, Maconellicoccus hirsutus (Green), based on numbers of adult males captured at traps baited with a synthetic pheromone. Trapping was conducted at three locations in east central Florida in ornamental plantings of hib...

  17. Heldeke, oled nii kaunis, et sadama hakkab : [luuletused] / Richard Brautigan ; tlk. Ingvar Luhaäär

    Index Scriptorium Estoniae

    Brautigan, Richard

    2007-01-01

    Sisu: Heldeke, oled nii kaunis, et sadama hakkab ; Veel keegi pole teinud seda nii säraliselt ; Kaunis luuletus ; Küüslauguga liha hõõruv Marcia ; Äri ; Mahedad hellused millesse ta mähib mu haavad ; Tunnen end vastikult ; "Kaasa lennates..."

  18. An Evaluation of the Antibullying Program at a Public Suburban High School

    Science.gov (United States)

    Drury, Brian

    2014-01-01

    This project study addressed the problem of harassment, intimidation, and bullying (HIB) at a public suburban high school in the Northeast United States. The study school implemented the Anti-bullying Program in September 2011, yet no evaluation had been conducted on whether the program was meeting its goals. Two conceptual frameworks that drove…

  19. Live vaccine against measles, mumps, and rubella and the risk of hospital admissions for nontargeted infections

    DEFF Research Database (Denmark)

    Sørup, Signe; Benn, Christine Stabell; Poulsen, Anja

    2014-01-01

    ). Nationwide Danish registers provided data on vaccinations and hospital admissions. The recommended vaccination schedule was inactivated vaccine against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (DTaP-IPV-Hib) administered at ages 3, 5, and 12 months and MMR at age 15 months...

  20. Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion-Induced Insulin Resistance.

    Science.gov (United States)

    Harris, Lydia-Ann L S; Smith, Gordon I; Patterson, Bruce W; Ramaswamy, Raja S; Okunade, Adewole L; Kelly, Shannon C; Porter, Lane C; Klein, Samuel; Yoshino, Jun; Mittendorfer, Bettina

    2017-07-01

    Systemic hyperaminoacidemia, induced by either intravenous amino acid infusion or protein ingestion, reduces insulin-stimulated glucose disposal. Studies of mice suggest that the valine metabolite 3-hydroxyisobutyrate (3-HIB), fibroblast growth factor 21 (FGF21), adiponectin, and nonesterified fatty acids (NEFAs) may be involved in amino acid-mediated insulin resistance. We therefore measured in 30 women the rate of glucose disposal, and plasma 3-HIB, FGF21, adiponectin, and NEFA concentrations, under basal conditions and during a hyperinsulinemic-euglycemic clamp procedure (HECP), with and without concomitant ingestion of protein (n = 15) or an amount of leucine that matched the amount of protein (n = 15). We found that during the HECP without protein or leucine ingestion, the grand mean ± SEM plasma 3-HIB concentration decreased (from 35 ± 2 to 14 ± 1 µmol/L) and the grand median [quartiles] FGF21 concentration increased (from 178 [116, 217] to 509 [340, 648] pg/mL). Ingestion of protein, but not leucine, decreased insulin-stimulated glucose disposal (P ingestion altered plasma adiponectin or NEFA concentrations. These findings suggest that 3-HIB and FGF21 might be involved in protein-mediated insulin resistance in humans. © 2017 by the American Diabetes Association.

  1. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis

    NARCIS (Netherlands)

    Darby, Crystal M; Ingólfsson, Helgi I; Jiang, Xiuju; Shen, Chun; Sun, Mingna; Zhao, Nan; Burns, Kristin; Liu, Gang; Ehrt, Sabine; Warren, J David; Andersen, Olaf S; Anderson, Olaf S; Brickner, Steven J; Nathan, Carl

    2013-01-01

    Bacterial pathogens like Mycobacterium tuberculosis (Mtb) encounter acidic microenvironments in the host and must maintain their acid-base homeostasis to survive. A genetic screen identified two Mtb strains that cannot control intrabacterial pH (pHIB) in an acidic environment; infection with either

  2. Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines.

    Science.gov (United States)

    Prymula, Roman; Chlibek, Roman; Splino, Miroslav; Kaliskova, Eva; Kohl, Igor; Lommel, Patricia; Schuerman, Lode

    2008-08-18

    This randomized (1:1), double-blind, multicenter study, included 4,968 healthy infants to receive either the 11-valent pneumococcal protein D (PD)-conjugate study vaccine or the hepatitis A vaccine (HAV) (control) at 3, 4, 5, and 12-15 months of age. The three-dose primary course of both vaccines was co-administered with combined hexavalent DTPa-HBV-IPV/Hib vaccine. The pneumococcal PD-conjugate study vaccine did not impact the immune response of co-administered hexavalent vaccine and the control HAV vaccine induced seropositivity (antibodies >or=15 mIU/mL) in all infants. The incidence of solicited symptoms was higher with the 11-valent pneumococcal PD-conjugate study vaccine, yet similar to that induced by concomitant DTPa-HBV-IPV/Hib vaccine. Overall, the reactogenicity and safety profile of the 11-valent pneumococcal PD-conjugate vaccine when co-administered with the hexavalent DTPa-HBV-IPV/Hib vaccine, as well as the immunogenicity of the co-administered hexavalent vaccine, were consistent with previous reports for the licensed DTPa-HBV-IPV/Hib and pneumococcal conjugate vaccines.

  3. Antibody responses of three Haemophilus influenzae type b conjugate vaccines after one, two and three doses in Filipino children.

    Science.gov (United States)

    Capeding, M R; Nohynek, H; Käyhty, H; Pascual, L G; Sunico, E S; Tamundong, A A; Ruutu, P

    1998-01-01

    Differences in the magnitude of antibody response after one, two or three doses of Haemophilus influenzae type b conjugate vaccines have been reported which may influence decision-making regarding which vaccine should be used. This is of particular importance in developing countries where children may not receive a full immunization series and the vaccination schedule may be delayed. Serum antibody responses to three Hib capsular polysaccharide protein conjugate vaccines (PRP-OMP, HbOC and PRP-T) were evaluated in 102 Filipino infants. Vaccination was carried out at 6, 10 and 14 weeks of age based on the national Expanded Programme on Immunization (EPI) schedule together with diphtheria-tetanus-pertussis, hepatitis B and oral poliomyelitis vaccines. Sera were collected at 6 weeks and 1 month after each vaccination. Anti-Hib polysaccharide antibody concentrations were determined by Farrtype radioimmunoassay (RIA) and enzymeimmunoassay (EIA), Following the first dose, the geometric mean concentrations (GMC, micrograms ml-1) for PRP-OMP, HbOC and PRP-T were 0.69, 0.27 and 0.38, respectively. After two doses, there was a significant response (P antibody responses were noted. The anti-Hib antibody concentrations determined by RIA and EIA were also compared in order to validate the latter for use in laboratories where it is feasible. There was a good correlation (r2 = 76%; P = 0.0001) in the Hib antibody titres obtained by both assays.

  4. To tilfaelde af invasive infektioner med Haemophilus influenzae type f

    DEFF Research Database (Denmark)

    Nielsen, Jette Dettmann; Lind, Jens; Bruun, Brita

    2009-01-01

    Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...

  5. [Two cases of invasive Haemophilus influenzae type f infection

    DEFF Research Database (Denmark)

    Nielsen, J.D.; Lind, J.W.; Bruun, B.

    2009-01-01

    Two cases of invasive Haemophilus influenzae type f infection are presented: a three-week-old boy with meningitis and a 62-year-old woman with arthritis and bacteremia. Since 1993 vaccination against H. influenzae type b (Hib) has been offered to Danish children. The result has been a remarkable...

  6. The costs and benefits of a vaccination programme for Haemophilus ...

    African Journals Online (AJOL)

    clinical d that further the etic, o the ome, e in ew ices low-up. in. 79. S Afr t. S Afr. South. Med h Dis ... from a successful vaccination programme) and the costs ... Drug Administration (FDA) licensed the Lederle Laboratories ... Direct costs necessitate analysis of Hib ... time and adjusted to allow for labour force participation. It.

  7. Adverse events following immunisation under the National Vaccination Programme of the Netherlands. Number XII - Reports in 2005

    NARCIS (Netherlands)

    van der Maas NAT; PHaff TAJ; Wesselo C; Dzaferagic A; Vermeer-de Bondt PE; CIE

    2007-01-01

    De bijwerkingenbewaking van het Rijksvaccinatieprogramma over 2005 liet een duidelijke afname zien van het aantal meldingen met 52%. Dit betrof vooral een daling van meldingen na DKTP-Hib vaccinaties. De daling in het aantal meldingen is toe te schrijven aan de overgang naar een acellulair DKTP-Hi

  8. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  9. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  10. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  11. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... thimerosal vaccine safety q & a videos chickenpox (varicella) hepatitis b hib hpv pertussis (whooping cough) pneumococcal rotavirus shingles media room Flu's Gonna Lose M.O.V.E. newsfeeds PSAs publications infectious disease workshop pediatric hepatitis report someone you know has hbv/hcv standard ...

  12. Invasive bacterial infections in Gambians with sickle cell anemia in an era of widespread pneumococcal and hemophilus influenzae type b vaccination.

    Science.gov (United States)

    Soothill, Germander; Darboe, Saffiatou; Bah, Gibril; Bolarinde, Lawal; Cunnington, Aubrey; Anderson, Suzanne T

    2016-12-01

    There is relatively little data on the etiology of bacterial infections in patients with sickle cell anemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and Haemophilus influenzae type b (Hib).We conducted a retrospective analysis of SCA patients admitted to the Medical Research Council Unit, The Gambia, during a 5-year period when there was high coverage of Hib and Pneumococcal conjugate vaccination. We evaluated 161 admissions of 126 patients between April 2010 and April 2015.Pathogenic bacteria were identified in blood cultures from 11 of the 131 admissions that had cultures taken (8.4%, 95% CI 4.5-14.1%). The most frequent isolate was Salmonella Typhimurium (6/11; 54.5%), followed by Staphylococcus aureus (2/11; 18.2%) and other enteric Gram-negative pathogens (2/11; 18.2%) and there was 1 case of H influenzae non-type b bacteremia (1/11; 9.1%). There were no episodes of bacteremia caused by S pneumoniae or Hib.The low prevalence of S pneumoniae and Hib and the predominance of nontyphoidal Salmonella as a cause of bacteremia suggest the need to reconsider optimal antimicrobial prophylaxis and the empirical treatment regimens for patients with SCA.

  13. IMMUNOGENICITY AND SAFETY OF QUINVAXEM® (DIPHTHERIA, TETANUS, WHOLE-CELL PERTUSSIS, HEPATITIS B AND HAEMOPHILUS INFLUENZAE TYPE B VACCINE) GIVEN TO VIETNAMESE INFANTS AT 2 TO 4 MONTHS OF AGE.

    Science.gov (United States)

    Huu, Tran Ngoc; Phuong, Nguyen Thi Minh; Toan, Nguyen Trong; Thang, Ho Vinh

    2015-07-01

    Vietnam plans to replace the routine childhood diphtheria, pertussis and tetanus combination (DPT) vaccine with a pentavalent vaccine. The present study was performed to assess the immunogenicity and safety of the combined diphtheria, tetanus, whole-cell pertussis, hepatitis B (HepB), and Haemophilus influenzae type b (Hib) (DTwP-HepB-Hib) Quinvaxem® vaccine in children. A total of 131 infants received the Quinvaxem® vaccine at 2, 3 and 4 months. Antibody levels were measured at baseline, at one month after the third injection and one year after the first injection. Seroprotection rates were high for each vaccine antigen at one month after the third dose: 93.1% for diphtheria, 98.5% for tetanus, 99.2% for pertussis (seroconversion rate), 93.1% for HepB, and 100% for Hib (anti-PRP ≥ 0.15 µg/ml). The rate of children with protective antibodies persisting at one year after the first dose was 88.4% for diphtheria, 49.6% for pertussis, 82.2% for tetanus, 76.7% for HepB and 97.7% for Hib (anti-PRP ≥ 0.15 µg/ml). The Quinvaxem® vaccine was well tolerated and has a low rate of adverse events. Quinvaxem® given at 2, 3 and 4 months of age was immunogenic and safe for primary immunization among infants in Vietnam.

  14. SMSi saatmise kasv plahvatuslik / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2007-01-01

    Eesti Telekomi andmetel on praegu väga kiiresti kasvavad sõnumiteenuse ja mobiilse Interneti tulud. Lisa: Kiiret kasvu naudivad ka väikesed. Tabel: Telekom rühib üles. Vt. samas: SMS-õnnemänguga miljonäriks

  15. Mass deformations of four-dimensional, rank 1, N=2 superconformal field theories

    OpenAIRE

    Argyres, Philip C.; Wittig, John

    2010-01-01

    Turning on N=2 supersymmetry-preserving relevant operators in a 4-dimensional N=2 superconformal field theory (SCFT) corresponds to a complex deformation compatible with the rigid special Kahler geometry encoded in the low energy effective action. Field theoretic consistency arguments indicate that there should be many distinct such relevant deformations of each SCFT fixed point. Some new supersymmetry-preserving complex deformations are constructed of isolated rank 1 SCFTs. We also make pred...

  16. SUSY flavor structure of generic 5D supergravity models

    CERN Document Server

    Abe, Hiroyuki; Sakamura, Yutaka; Yamada, Yusuke

    2011-01-01

    We perform a comprehensive and systematic analysis of the SUSY flavor structure of generic 5D supergravity models on $S^1/Z_2$ with multiple $Z_2$-odd vector multiplets that generate multiple moduli. The SUSY flavor problem can be avoided due to contact terms in the 4D effective K\\"ahler potential peculiar to the multi-moduli case. A detailed phenomenological analysis is provided based on an illustrative model.

  17. On SUSY Restoration in Single-Superfield Inflationary Models of Supergravity

    CERN Document Server

    Ketov, Sergei V

    2016-01-01

    We study the conditions of restoring supersymmetry (SUSY) after inflation in the supergravity-based cosmological models with a single chiral superfield and a quartic stabilization term in the K\\"ahler potential. Some new, explicit, and viable inflationary models satisfying those conditions are found. The inflaton's scalar superpartner is dynamically stabilized during and after inflation. We also demonstrate a possibility of having small and adjustable SUSY breaking with a tiny cosmological constant.

  18. Almost complex connections on almost complex manifolds with Norden metric

    OpenAIRE

    Teofilova, Marta

    2011-01-01

    A four-parametric family of linear connections preserving the almost complex structure is defined on an almost complex manifold with Norden metric. Necessary and sufficient conditions for these connections to be natural are obtained. A two-parametric family of complex connections is studied on a conformal K\\"{a}hler manifold with Norden metric. The curvature tensors of these connections are proved to coincide.

  19. Deformations of extremal toric manifolds

    CERN Document Server

    Rollin, Yann

    2012-01-01

    Let $X$ be a compact toric extremal K\\"ahler manifold. Using the work of Sz\\'ekelyhidi, we provide a simple criterion on the fan describing $X$ to ensure the existence of complex deformations of $X$ that carry extremal metrics. As an example, we find new CSC metrics on 4-points blow-ups of $\\C\\P^1\\times\\C\\P^1$.

  20. Strong generic vanishing and a higher-dimensional Castelnuovo–de Franchis inequality

    OpenAIRE

    Pareschi, Giuseppe; Popa, Mihnea

    2009-01-01

    We extend to manifolds of arbitrary dimension the Castelnuovo-de Franchis inequality for surfaces. The proof is based on the theory of Generic Vanishing and higher regularity, and on the Evans-Griffith Syzygy Theorem in commutative algebra. Along the way we give a positive answer, in the setting of K\\"ahler manifolds, to a question of Green-Lazarsfeld on the vanishing of higher direct images of Poincar\\'e bundles. We indicate generalizations to arbitrary Fourier-Mukai transforms.

  1. The Hidden Dimension of Strategic Planning: Explorations in the Formation of Perspectives

    Science.gov (United States)

    1991-09-01

    of Ideas, (New York: Charles Scribner’s Sons, 1969), 33. 64 Fromm , Erich , To Have Or To Be?, (New York: Harper & Row, Publishers, Inc., 1976), 133. 65...Neurobiology Review. Berkeley: Institute of Electrical and Electronics Engineers, IEEE, Inc. 1989. Fromm , Erich . To Have Or To Be?. New York: Harper & Row...something more than time... -- Erich Kahler, Man The Measure. Every shift in the course of events changes the bearing of the past upon the present. --S. P

  2. Symbolic calculus for Toeplitz operators with half-forms

    OpenAIRE

    Charles, L.

    2006-01-01

    This paper is devoted to the use of half-form bundles in the symbolic calculus of Berezin-Toeplitz operators on Kahler manifolds. We state the Bohr-Sommerfeld conditions and relate them to the functional calculus of Toeplitz operators, a trace formula and the characteristic classes in deformation quantization. We also develop the symbolic calculus of Lagrangian sections, with the crucial estimate of the subprincipal terms.

  3. Anomaly-induced inflaton decay and gravitino-overproduction problem

    Energy Technology Data Exchange (ETDEWEB)

    Endo, M.; Takahashi, F. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Yanagida, T.T. [Tokyo Univ. (Japan). Dept. of Physics]|[Tokyo Univ. (Japan). Research Center for the Early Universe

    2007-01-15

    We point out that the inflaton spontaneously decays into any gauge bosons and gauginos via the super-Weyl, Kahler and sigma-model anomalies in supergravity, once the inflaton acquires a non-vanishing vacuum expectation value. In particular, in the dynamical supersymmetry breaking scenarios, the inflaton necessarily decays into the supersymmetry breaking sector, if the inflaton mass is larger than the dynamical scale. This generically causes the overproduction of the gravitinos, which severely constrains the inflation models. (orig.)

  4. Lower bounds on the Calabi functional

    OpenAIRE

    Donaldson, S. K.

    2005-01-01

    The main result of this paper shows that "test configurations" give new lower bounds on the $L^{2}$ norm of the scalar curvature on a Kahler manifold. This is closely analogous to the analysis of the Yang-Mills functional over Riemann surfaces by Atiyah and Bott. The proof uses asymptotic approximation by finite-dimensional problems: the essential ingredient being the Tian-Zelditch-Lu expansion of the "density of states" function.

  5. Inflation Expels Runaways

    OpenAIRE

    Bachlechner, Thomas C.

    2016-01-01

    We argue that moduli stabilization generically restricts the evolution following transitions between weakly coupled de Sitter vacua and can induce a strong selection bias towards inflationary cosmologies. The energy density of domain walls between vacua typically destabilizes Kahler moduli and triggers a runaway towards large volume. This decompactification phase can collapse the new de Sitter region unless a minimum amount of inflation occurs after the transition. A stable vacuum transition ...

  6. On Gaussian random supergravity

    OpenAIRE

    Bachlechner, Thomas C.

    2014-01-01

    We study the distribution of metastable vacua and the likelihood of slow roll inflation in high dimensional random landscapes. We consider two examples of landscapes: a Gaussian random potential and an effective supergravity potential defined via a Gaussian random superpotential and a trivial K\\"ahler potential. To examine these landscapes we introduce a random matrix model that describes the correlations between various derivatives and we propose an efficient algorithm that allows for a nume...

  7. Some Navigation Rules for D-Brane Monodromy

    CERN Document Server

    Aspinwall, Paul S

    2001-01-01

    We explore some aspects of monodromies of D-branes in the Kahler moduli space of Calabi-Yau compactifications. Here a D-brane is viewed as an object of the derived category of coherent sheaves. We compute all the interesting monodromies in some nontrivial examples and link our work to recent results and conjectures concerning helices and mutations. We note some particular properties of the 0-brane.

  8. Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000–2012

    Directory of Open Access Journals (Sweden)

    Raymond S. W. Tsang

    2016-01-01

    Full Text Available Background: With invasive Haemophilus influenzae serotype b (Hib disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. Objective: This study characterized invasive H. influenzae (Hi isolates from Nunavut, Canada, in the post-Hib vaccine era. Methods: Invasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility. Results: Of the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia, 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT. All 43 Hia were biotype II, sequence type (ST-23. Three related STs were found among the Hib isolates: ST-95 (n=9, ST-635 (n=2 and ST-44 (n=1. Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288 and Hie (ST-18 belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ampicillin due to β-lactamase production. No resistance to other antibiotics was detected. Conclusion: During the period of 2000–2012, Hia was the predominant serotype causing invasive disease in Nunavut. This presents a public health concern due to an emerging clone of Hia as a cause of invasive H. influenzae disease and the lack of published guidelines for the prophylaxis of contacts. The clonal nature of Hia could be the result of spread within an isolated population, and/or unique characteristics of this strain to cause invasive disease. Further study of Hia in other populations may provide important information on this emerging pathogen. No antibiotic resistance was detected among Hia

  9. Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000-2012.

    Science.gov (United States)

    Tsang, Raymond S W; Li, Y Anita; Mullen, Angie; Baikie, Maureen; Whyte, Kathleen; Shuel, Michelle; Tyrrell, Gregory; Rotondo, Jenny A L; Desai, Shalini; Spika, John

    2016-01-01

    With invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. This study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib vaccine era. Invasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility. Of the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia), 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT). All 43 Hia were biotype II, sequence type (ST)-23. Three related STs were found among the Hib isolates: ST-95 (n=9), ST-635 (n=2) and ST-44 (n=1). Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288) and Hie (ST-18) belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ampicillin due to β-lactamase production. No resistance to other antibiotics was detected. During the period of 2000-2012, Hia was the predominant serotype causing invasive disease in Nunavut. This presents a public health concern due to an emerging clone of Hia as a cause of invasive H. influenzae disease and the lack of published guidelines for the prophylaxis of contacts. The clonal nature of Hia could be the result of spread within an isolated population, and/or unique characteristics of this strain to cause invasive disease. Further study of Hia in other populations may provide important information on this emerging pathogen. No antibiotic resistance was detected among Hia isolates; a small proportion of Hib and NT-Hi isolates

  10. Nationwide survey of the development of drug resistance in the pediatric field in 2007, 2010, and 2012: drug sensitivity of Haemophilus influenzae serotype b strain in Japan.

    Science.gov (United States)

    Baba, Hiroaki; Sato, Yoshitake; Toyonaga, Yoshikiyo; Hanaki, Hideaki; Sunakawa, Keisuke

    2015-04-01

    Based on the results of surveillance in the pediatric field conducted in 2007, 2010, and 2012, we examined the frequency of Haemophilus influenzae serotype b (Hib) strains, the susceptibility for Hib strains to various types of antimicrobial agent, and the relations to patients' background factors. Among all of Haemophilus influenzae, the frequency of Hib strains was 3.6% (14/386 strains) in 2007, 4.8% (23/484 strains) in 2010, 1.2% (5/411 strains) in 2012, and decreasing in 2012. Hib strains were isolated in patients with the following infections: nine patients with respiratory tract infections (upper respiratory tract infection, bronchitis, and pneumonia), three patients with sepsis, one patient with meningitis, and one patient with purulent inflammation of a tendon sheath in 2007; 11 patients with respiratory tract infections (upper respiratory tract infection, bronchitis, and pneumonia), four patients with sepsis, and eight patients with meningitis in 2010, demonstrating a relatively high frequency in patients with invasive infections. However, in 2012, Hib strains were isolated in only four patients with respiratory tract infections (upper respiratory tract infection) and one patient with bronchial asthma. Evaluation of background factors with pediatric patients in whom Hib strains were isolated showed that approximately 70% were male; majority was children under three years of age; and higher detection rates were also related to the background of patients who were attendant to daycare center, had siblings, had received no antimicrobial agents within the previous one month before collecting specimens. Throughout the surveillance between 2007 and 2012, antimicrobial agents with all phases' MICs ≤ 1 μg/mL were cefditoren, cefcapene, and cefteram in the oral β-lactams; tazobactam/piperacillin, ceftriaxone, cefotaxime, and meropenem in the injectable β-lactams; azithromycin in the macrolide; and levofloxacin in the quinolone. After 2010, MIC ranges were

  11. Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000–2012

    Science.gov (United States)

    Tsang, Raymond S. W.; Li, Y. Anita; Mullen, Angie; Baikie, Maureen; Whyte, Kathleen; Shuel, Michelle; Tyrrell, Gregory; Rotondo, Jenny A. L.; Desai, Shalini; Spika, John

    2016-01-01

    Background With invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. Objective This study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib vaccine era. Methods Invasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility. Results Of the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia), 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT). All 43 Hia were biotype II, sequence type (ST)-23. Three related STs were found among the Hib isolates: ST-95 (n=9), ST-635 (n=2) and ST-44 (n=1). Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288) and Hie (ST-18) belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ampicillin due to β-lactamase production. No resistance to other antibiotics was detected. Conclusion During the period of 2000–2012, Hia was the predominant serotype causing invasive disease in Nunavut. This presents a public health concern due to an emerging clone of Hia as a cause of invasive H. influenzae disease and the lack of published guidelines for the prophylaxis of contacts. The clonal nature of Hia could be the result of spread within an isolated population, and/or unique characteristics of this strain to cause invasive disease. Further study of Hia in other populations may provide important information on this emerging pathogen. No antibiotic resistance was detected among Hia isolates; a

  12. Optimization of the purification process of Haemophilus influenzae type b polysaccharide%b型流感嗜血杆菌多糖纯化工艺的优化

    Institute of Scientific and Technical Information of China (English)

    王伟; 马雷钧; 沈坚; 陈晓怿; 马相虎

    2014-01-01

    目的 优化b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)多糖纯化工艺,替代传统的苯酚结合乙醇方法.方法 采用十六烷基三甲基溴化铵提取粗糖,以脱氧胆酸钠结合乙醇多级纯化进一步纯化粗糖,通过超滤浓缩和除菌过滤获得纯化的Hib多糖.采用优化的纯化工艺以中试和放大规模各纯化3批Hib多糖,按照《中华人民共和国药典》2010年版三部的要求检测纯化的Hib多糖.结果 中试和放大规模纯化的各3批Hib多糖的相对分子质量分别为621 800、634 400、659 900和597 200、612 100、583 400,均符合规定的标准.中试和放大规模纯化的各3批Hib多糖的细菌内毒素含量分别为2.0、0.5、0.7 EU/μg和4.0、2.0、1.0 EU/μg,均明显低于规定的标准.鉴别试验显示,中试和放大规模纯化的各批Hib多糖均可与标准Hib抗血清形成明显的沉淀线.结论 优化的Hib多糖纯化工艺具有较好的稳定性,且易于工艺放大,可替代传统工艺用于Hib多糖的纯化.%Objective To optimize the purification process of Haemophilus influenzae type b (Hib) polysaccharide for replacing the traditional combination of phenol and ethanol.Methods Crude Hib polysaccharides were extracted with Cetavlon and further purified with the combination of sodium deoxycholate and ethanol multistage purification,and purified polysaccharides were obtained by ultrafiltration and sterilizing filtration.Three batches of purified Hib polysaccharides were prepared with the optimized purification precess in pilot and other 3 batches in amplifying scales.Prepared Hib polysaccharides were detected in accordance with the Chinese Pharmacopoeia 2010 edition (Volume Ⅲ).Results The relative molecular masses of each 3 batches of Hib polysaccharides purified in pilot and amplifying scales were 621 800,634 400,659 900 and 597 200,612 100,583 400,respectively,and all met standard requirement.The contents of bacterial endotoxin of each 3 batches

  13. Order of Meromorphic Maps and Rationality of the Image Space

    CERN Document Server

    Noguchi, Junjiro

    2011-01-01

    Let $\\iota : \\C^2 \\hookrightarrow S$ be a compactification of the two dimensional complex space $\\C^2$. By making use of Nevanlinna theoretic methods and the classification of compact complex surfaces K. Kodaira proved in 1971 (\\cite{ko71}) that $S$ is a rational surface. Here we deal with a more general meromorphic map $f: \\C^n \\to X$ into a compact complex manifold $X$ of dimension $n$, whose differential $df$ has generically rank $n$. Let $\\rho_f$ denote the order of $f$. We will prove that if $\\rho_f<2$, then every global symmetric holomorphic tensor must vanish; in particular, {\\it if $\\dim X=2$ and $X$ is k\\"ahler, then $X$ is a rational surface. Without the k\\"ahler condition there is no such conclusion, as we will show by a counter-example using a Hopf surface.} This may be the first instance that the k\\"ahler or non-k\\"ahler condition makes a difference in the value distribution theory.

  14. Higgs-otic Inflation and Moduli Stabilization

    CERN Document Server

    Bielleman, Sjoerd; Pedro, Francisco G; Valenzuela, Irene; Wieck, Clemens

    2016-01-01

    We study closed-string moduli stabilization in Higgs-otic inflation in Type IIB orientifold backgrounds with fluxes. In this setup large-field inflation is driven by the vacuum energy of mobile D7-branes. Imaginary selfdual (ISD) three-form fluxes in the background source a $\\mu$-term and the necessary monodromy for large field excursions while imaginary anti-selfdual (IASD) three-form fluxes are sourced by non-perturbative contributions to the superpotential necessary for moduli stabilization. We analyze K\\"ahler moduli stabilization and backreaction on the inflaton potential in detail. Confirming results in the recent literature, we find that integrating out heavy K\\"ahler moduli leads to a controlled flattening of the inflaton potential. We quantify the flux tuning necessary for stability even during large-field inflation. Moreover, we study the backreaction of supersymmetrically stabilized complex structure moduli and the axio-dilaton in the K\\"ahler metric of the inflaton. Contrary to previous findings, ...

  15. Stability of extremal metrics under complex deformations

    CERN Document Server

    Rollin, Yann; Tipler, Carl

    2011-01-01

    Let $(\\mathcal {X},\\Omega)$ be a closed polarized complex manifold, $g$ be an extremal metric on $\\mathcal X$ that represents the K\\"ahler class $\\Omega$, and $G$ be a compact connected subgroup of the isometry group $Isom(\\mathcal{X},g)$. Assume that the Futaki invariant relative to $G$ is nondegenerate at $g$. Consider a smooth family $(\\mathcal{M}\\to B)$ of polarized complex deformations of $(\\mathcal{X},\\Omega)\\simeq (\\mathcal{M}_0,\\Theta_0)$ provided with a holomorphic action of $G$. Then for every $t\\in B$ sufficiently small, there exists an $h^{1,1}(\\cX)$-dimensional family of extremal K\\"ahler metrics on $\\mathcal{M}_t$ whose K\\"ahler classes are arbitrarily close to $\\Theta_t$. We apply this deformation theory to analyze the Mukai-Umemura 3-fold and its complex deformations. In particular, we prove that there are certain complex deformation of the Mukai-Umemura 3-folds which have extremal metric of non constant scalar curvature with Kaehler class $c_1$.

  16. Aligned Natural Inflation and Moduli Stabilization from Anomalous $U(1)$ Gauge Symmetries

    CERN Document Server

    Li, Tianjun; Nanopoulos, Dimitri V

    2014-01-01

    To obtain natural inflation with large tensor-to-scalar ratio in string framework, we need a special moduli stabilization mechanism which can separate the masses of real and imaginary components of K\\"ahler moduli at different scales, and achieve a trans-Planckian axion decay constant from sub-Planckian axion decay constants. In this work, we stabilize the matter fields by F-terms and the real components of K\\"ahler moduli by D-terms of two anomalous $U(1)_X\\times U(1)_A$ symmetries strongly at high scales, while the corresponding axions remain light due to their independence on the Fayet-Iliopoulos (FI) term in moduli stabilization. The racetrack-type axion superpotential is obtained from gaugino condensations of the hidden gauge symmetries $SU(n)\\times SU(m)$ with massive matter fields in the bi-fundamental respresentations. The axion alignment via Kim-Nilles-Pelroso (KNP) mechanism corresponds to an approximate $S_2$ exchange symmetry of two K\\"ahler moduli in our model, and a slightly $S_2$ symmetry break...

  17. Volume modulus inflation and a low scale of SUSY breaking

    CERN Document Server

    Badziak, M

    2008-01-01

    The relation between the Hubble constant and the scale of supersymmetry breaking is investigated in models of inflation dominated by a string modulus. Usually in this kind of models the gravitino mass is of the same order of magnitude as the Hubble constant which is not desirable from the phenomenological point of view. It is shown that slow-roll saddle point inflation may be compatible with a low scale of supersymmetry breaking only if some corrections to the lowest order Kahler potential are taken into account. However, choosing an appropriate Kahler potential is not enough. There are also conditions for the superpotential, and e.g. the popular racetrack superpotential turns out to be not suitable. A model is proposed in which slow-roll inflation and a light gravitino are compatible. It is based on a superpotential with a triple gaugino condensation and the Kahler potential with the leading string corrections. The problem of fine tuning and experimental constraints are discussed for that model.

  18. Induced-Gravity Inflation in Supergravity Confronted with Planck 2015 & BICEP2/Keck Array

    CERN Document Server

    Pallis, C

    2015-01-01

    Supersymmetric versions of induced-gravity inflation are formulated within Supergravity (SUGRA) employing two gauge singlet chiral superfields. The proposed superpotential is uniquely determined by applying a continuous R and a discrete Z_2 symmetry. We also employ a logarithmic Kahler potential respecting the symmetries above and including all the allowed terms up to fourth order in powers of the various fields. When the Kahler manifold exhibits a no-scale-type symmetry, the model predicts spectral index ns=0.963 and tensor-to-scalar r=0.004. Beyond no-scale SUGRA, ns and r depend crucially on the coefficient ksphi involved in the fourth order term, which mixes the inflaton \\Phi\\ with the accompanying non-inflaton superfield S in the Kahler potential, and the prefactor encountered in it. Increasing slightly the latter above (-3), an efficient enhancement of the resulting r can be achieved putting it in the observable range favored by the Planck and BICEP2/Keck Array results. In all cases, imposing a lower bo...

  19. Reconciling Induced-Gravity Inflation in Supergravity With The BICEP2 Results

    CERN Document Server

    Pallis, C

    2014-01-01

    We generalize the embedding of induced-gravity inflation beyond the no-scale Supergravity presented in arXiv:1403.5486 employing two gauge singlet chiral superfields, a superpotential uniquely determined by applying a continuous R and a discrete Zn symmetries, and a logarithmic Kahler potential including all the allowed terms up to fourth order in powers of the various fields. We show that, increasing slightly the prefactor (-3) encountered in the adopted Kahler potential, an efficient enhancement of the resulting tensor-to-scalar ratio can be achieved rendering the predictions of the model consistent with the recent BICEP2 results, even with subplanckian excursions of the original inflaton field. The remaining inflationary observables can become compatible with the data by mildly tuning the coefficient involved in the fourth order term of the Kahler potential which mixes the inflaton with the accompanying non-inflaton field. The inflaton mass is predicted to be close to 10^14 GeV.

  20. Coupling the Inflationary Sector to Matter

    CERN Document Server

    Kallosh, Renata; Wrase, Timm

    2016-01-01

    We describe the coupling of matter fields to an inflationary sector of supergravity, the inflaton $\\Phi$ and a stabilizer $S$, in models where the Kahler potential has a flat inflaton direction. Such models include, in particular, advanced versions of the hyperbolic $\\alpha$-attractor models with a flat inflaton direction Kahler potential, providing a good fit to the observational data. If the superpotential is at least quadratic in the matter fields $U^{i}$, with restricted couplings to the inflaton sector, we prove that under certain conditions: i) The presence of the matter fields does not affect a successful inflationary evolution. ii) There are no tachyons in the matter sector during and after inflation. iii) The matter masses squared are higher than $3H^2$ during inflation. The simplest class of theories satisfying all required conditions is provided by models with a flat direction Kahler potential, and with the inflaton $\\Phi$ and a stabilizer $S$ belonging to a hidden sector, so that matter fields hav...