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Sample records for juvenile-onset generalized demodicosis

  1. Demodicosis: a clinicopathological study.

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    Hsu, Chao-Kai; Hsu, Mark Ming-Long; Lee, Julia Yu-Yun

    2009-03-01

    Demodex mites are common commensal organisms of the pilosebaceous unit in human beings and have been implicated in pityriasis folliculorum, rosacea-like demodicosis, and demodicosis gravis. We sought to describe the spectrum of clinicopathological findings and therapeutic responses of demodicosis in Taiwanese patients. We conducted a retrospective study to review clinicopathologic findings and therapeutic responses of 34 cases of diagnosed demodicosis. Fifteen cases with positive results of potassium hydroxide examination, standardized skin surface biopsy specimen, and/or skin biopsy specimen, and resolution of skin lesions after anti-Demodex treatment were included for final analysis. Nineteen cases were excluded because of insufficient positive data to make a definite diagnosis. There were 4 male and 11 female patients (age 1-64 years, mean age 38.7 years). The disease was recurrent or chronic with a duration ranging from 2 months to 5 years (mean 15.7 months). The skin lesions were acne rosacea-like (n = 8), perioral dermatitis-like (n = 5), granulomatous rosacea-like (n = 1), and pityriasis folliculorum (n = 1). Skin biopsy was performed in 7 patients. Overall, the histopathology was characterized by: (1) dense perivascular and perifollicular lymphohistiocytic infiltrates, often with abundant neutrophils and occasionally with multinucleated histiocytes; (2) excessive Demodex mites in follicular infundibula; and (3) infundibular pustules containing mites or mites in perifollicular inflammatory infiltrate. The skin lesions resolved after treatment including systemic metronidazole, topical metronidazole, crotamiton, or gamma benzene hexachloride. Small sample size and a fraction of patients without long-term follow-up are limitations. Demodicosis should be considered in the differential diagnosis of recurrent or recalcitrant rosacea-like, granulomatous rosacea-like, and perioral dermatitis-like eruptions of the face. Potassium hydroxide examination, standardized

  2. Serum detection of IgG antibodies against Demodex canis by western blot in healthy dogs and dogs with juvenile generalized demodicosis.

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    Ravera, Ivan; Ferreira, Diana; Gallego, Laia Solano; Bardagí, Mar; Ferrer, Lluís

    2015-08-01

    The aim of this study was to investigate the presence of canine immunoglobulins (Ig) G against Demodex proteins in the sera of healthy dogs and of dogs with juvenile generalized demodicosis (CanJGD) with or without secondary pyoderma. Demodex mites were collected from dogs with CanJGD. Protein concentration was measured and a western blot technique was performed. Pooled sera from healthy dogs reacted mainly with antigen bands ranging from 55 to 72 kDa. Pooled sera from dogs with CanJGD without secondary pyoderma reacted either with 10 kDa antigen band or 55 to 72 kDa bands. Pooled sera from dogs with CanJGD with secondary pyoderma reacted only with a 10 kDa antigen band. The results of this study suggest that both healthy dogs and dogs with CanJGD develop a humoral response against different proteins of Demodex canis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Canine demodicosis in territory of city of Niš

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    Stojiljković Dragoslav

    2006-01-01

    Full Text Available This paper describes cases of demodicosis in dogs from the territory of the city of Niš. The objective of the investigations was to learn more about the parameters that can influence the susceptibility of certain dogs to the cause of demodicosis, such as: age, hair length, sex, and seasonal dynamics of the incidence of the disease. It was established following examinations of 76 dogs suspected of demodicosis that they were all infected with the specie Demodex canis. The changes were localized or generalized. In the total number of infected dogs, there was a larger share of males (61.84% than females (38.16%. The number of dogs diseased with demodicosis was twice higher in shorthaired than in long-haired animals. The most frequently infected were dogs of the Doberman and German Shepherd breeds. The number of male and female animals among short-haired dogs diseased with demodicosis was equal, while there were more males among the long-haired animals. The biggest number of infected animals was in the category of young dogs, up to one year of age, and they accounted for 65.79% of the total number of diseased animals, which shows without any doubt that younger dogs are more susceptible to demodicosis. There were more infected dogs in the period autumn-winter than in the period spring-summer.

  4. Hypoglycemia and hemostatic parameters in juvenile-onset diabetes

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    Hilsted, J; Madsbad, S; Nielsen, J D;

    1980-01-01

    Hypoglycemia was induced by intravenous infusion of insulin in six juvenile-onset diabetic subjects. Hemostatic parameters were assessed before insulin infusion and 0, 1, and 2 h after discontinuation of insulin infusion. The onset of hypoglycemia coincided with an enhancement of ADP-induced plat......Hypoglycemia was induced by intravenous infusion of insulin in six juvenile-onset diabetic subjects. Hemostatic parameters were assessed before insulin infusion and 0, 1, and 2 h after discontinuation of insulin infusion. The onset of hypoglycemia coincided with an enhancement of ADP...... potentially lead to intravascular coagulation in juvenile-onset diabetic patients....

  5. An Update on Therapeutic Management of Canine Demodicosis

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    S. K. Singh

    2011-02-01

    Full Text Available Canine demodicosis is a common noncontagious parasitic dermatosis caused by different spp of Demodex mites including Demodex canis, Demodex injai and D. cornei. Generalized demodicosis can be one of the most frustrating skin diseases, one will ever treat. Conventional and newer miticidal therapies are available to veterinarian to treat this frustrating skin disease. All recognized Demodex mites in dogs appear to respond similarly to mite targeted therapy. Treatment for canine demodicosis includes amitraz, ivermectin, milbemicin oxime, moxidectin, and doramectin. The use of any glucocorticoid-containing products is contraindicated and could favour disease generalization. Conventional treatments will often appear to work however, but it relies heavily on a highly toxic method of treatment. Using natural remedies for mange, on the other hand, can enhance the dog’s immune system, so that the body can fight off the mange mite infection by itself. [Veterinary World 2011; 4(1.000: 41-44

  6. Demodicosis in Renal Transplant Recipients.

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    Chovatiya, R J; Colegio, O R

    2016-02-01

    Solid organ transplant recipients have an increased incidence of skin infections resulting from immunosuppression. Common pathogens include herpes simplex virus, varicella zoster virus, Gram-positive bacteria and dermatophytes; however, the contribution of multicellular parasitic organisms to dermatologic disease in this population remains less studied. Demodex folliculorum and brevis are commensal mites that reside on human skin. Proliferation of Demodex mites, or demodicosis, is associated with rosacea and rosacea-like disorders, particularly in immunocompromised populations, although their ability to cause disease is still the subject of debate. We present a case series of four renal transplant recipients with the singular chief complaint of acne rosacea who we diagnosed with demodicosis. Although one of the four patients showed complete resolution following initial antiparasitic therapy, the other three required subsequent antibacterial treatment to fully resolve their lesions. We suggest that demodicosis may be more prevalent than once thought in solid organ transplant recipients and showed that Demodex-associated acne rosacea can be effectively treated in this population.

  7. Juvenile onset ankylosing spondylitis with ankylosing tarsitis: a rare combination.

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    Siddiq, A B; Hasan, S A; Abdullah, A M; Azad, S A; Khan, E H; Khasru, M R

    2012-01-01

    Ankylosing spondylitis is the most common whereas ankylosing tarsitis is the least common subgroup of juvenile onset spondyloarthritides. In our recent study a male presented with ankle joint pain and swelling with limited movements and characteristic radiological changes including; periarticular swelling, thickened heel pad, hyperostosis and reduced ankle, calcaneo-cuboid and talo-navicular joint space for ankylosing tarsitis. He also had persistent inflammatory low back pain with radiological sacroilitis satisfying the clinical features for ankylosing spondylitis. The patient was treated with different anti-inflammatory agents including intra-articular methyl-prednisolone with short-term relief. Associated back pain was improved with spine mobilizing exercise.

  8. Eficácia das lactonas macrocíclicas sistêmicas (ivermectina e moxidectina na terapia da demodicidose canina generalizada Efficacy of systemics macrocyclic lactones (ivermectin and moxidectin for the treatment of generalized canine demodicosis

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    E.H. Delayte

    2006-02-01

    Full Text Available Avaliou-se a eficácia de lactonas macrocíclicas (ivermectina e moxidectina sobre a eventual ocorrência de efeitos colaterais e acompanharam-se, após a alta parasitológica, por 12 meses, os cães tratados, visando detectar a recidiva do quadro dermatopático. Dos 63 animais, 59% eram fêmeas, 76% apresentavam precisa definição racial e 67% tinham pelame curto. A ivermectina (0,6mg/kg/dia foi administrada por via oral a 31 cães, e a moxidectina (0,5mg/kg/cada 72 horas, pela mesma via, a 32 animais. Os tempos médios para a obtenção da primeira negativação do exame parasitológico do raspado cutâneo e para a consecução da alta foram, respectivamente, de 90 e 130 dias para a ivermectina e de 108 e 147 dias para a moxidectina. A ivermectina acarretou menos (16,1% efeitos colaterais em relação à moxidectina (37,5% (P=0,03. As recidivas foram, respectivamente, 10,3% e 13% para ivermectina e moxidectina. Não houve diferença entre os dois protocolos de terapia quanto aos percentuais de recidiva (P=0,67 e eficácia (P=0,61. Ambas as lactonas macrocíclicas mostraram-se eficazes: ivermectina 89,7% e moxidectina 87%.The efficacy of ivermectin and moxidectin for treatment of generalized canine demodicosis, was evaluated to detect the eventual occurrence of side effects caused by the use of these drugs, and to follow the treated dogs for 12 months after obtaining parasitologic cure. Of 63 dogs, 59% were females, 76% were defined as purebred and 67% had short hair. Ivermectin (0.6mg/kg/daily was orally administered to 31 dogs and moxidectin (0.5mg/kg/every 72 hours to 32 dogs. The average number of days to obtain the first negative skin scraping results and the parasitologic cure were, respectively, 90 and 130 days for ivermectin, and 108 and 147 days for moxidectin. Ivermectin caused fewer side effects (16.1% than moxidectin (37.5% (P0.67 and efficacy (P>0.61. Both drugs were effective and safe to treat generalized canine demodicosis

  9. Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

    NARCIS (Netherlands)

    E. Kruithof; V. van den Bossche; L. de Rycke; B. Vandooren; R. Joos; J.D. Canete; P.P. Tak; A.M.H. Boots; E.M. Veys; D. Baeten

    2006-01-01

    Objective. To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA). Methods. Synovial biopsy samples were obtained from 10 patients with juvenile-onset SpA, 23 with adult SpA, 19 w

  10. Ivermectin treatment of demodicosis in 56 hamsters.

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    Tani, K; Iwanaga, T; Sonoda, K; Hayashiya, S; Hayashiya, M; Taura, Y

    2001-11-01

    Fifty-six hamsters with demodicosis were treated with daily oral administration of ivermectin (0.3 mg/kg). Thirty-three cases (58.9%) were cured and 6 cases (10.7%) had improved clinically but needed to continue treatment. Of 5 cases (8.9%) who relapsed within 3 months and were retreated with ivermectin, 4 were cured and 1 needed further treatment. Five cases (8.9%) had improved clinically but died within 3 months. Seven cases (12.5%) had not improved and died within 3 months. Overall 49 (87.5%) hamsters had improved clinically. No significant differences in prognosis of demodicosis were detected according to sex, breed, age and clinical features, but the prognosis of demodicosis in hamsters with concurrent disease was poor.

  11. [Primary human demodicosis. A disease sui generis].

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    Hsu, C-K; Zink, A; Wei, K-J; Dzika, E; Plewig, G; Chen, W

    2015-03-01

    Human Demodex mites (Demodex folliculorum and Demodex brevis) are unique in that they are an obligate human ectoparasite that can inhabit the pilosebaceous unit lifelong without causing obvious host immune response in most cases. The mode of symbiosis between humans and human Demodex mites is unclear, while the pathogenicity of human Demodex mites in many inflammatory skin diseases is now better understood. Primary human demodicosis is a skin disease sui generis not associated with local or systemic immunosuppression. Diagnosis is often underestimated and differentiation from folliculitis, papulopustular rosacea and perioral dermatitis is not always straightforward. Dependent on the morphology and degree of inflammation, the clinical manifestations can be classified into spinulate, papulopustular, nodulocystic, crustic and fulminant demodicosis. Therapy success can be achieved only with acaricides/arachidicides. The effective doses, optimal regimen and antimicrobial resistance remain to be determined.

  12. Crusted Demodicosis in an Immunocompetent Pediatric Patient

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    Guillermo Antonio Guerrero-González

    2014-01-01

    Full Text Available Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.

  13. Feline demodicosis caused by an unnamed species.

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    Kano, Rui; Hyuga, Ayako; Matsumoto, Jun; Nogami, Sadao; Nemoto, Seiichi; Hasegawa, Atsuhiko; Kamata, Hiroshi

    2012-04-01

    A case of feline demodicosis is described in this report. A 13-year-old spayed female domestic short hair cat weighing 4.5 kg was being treated with cefovecin and alternately with prednisone or methylprednisolone. On further physical examination, the cat showed mild erythema and hair loss on the bridge of the nose, around the eyes, on the chin, on the side part of the breast and on the abdomen. A large number of Demodex mites were found in deep skin scrapings from the affected areas. The cat was then treated with ivermectin at 600 μg/kg administered SC daily. After 4 weeks of treatment, the cat was clinically normal with no mites detected in the skin scrapings from the face or breast areas. The mite responsible may represent a previously seen but as yet unnamed new species. This is third report that describes a case of feline demodicosis caused by a different, unnamed mite species that has different morphological characteristics to those of known Demodex mites and may represent a previously seen but as yet unnamed species.

  14. Clinical and genetic study of a juvenile-onset Huntington disease

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    HAO Ying

    2012-06-01

    Full Text Available Background Huntington's disease (HD is an autosomal dominant hereditary progressive neurodegenerative disorder with a distinct phenotype characterized by chorea, dementia, cognitive and affective impairment. There are selective neural cell loss and atrophy in the caudate and putamen. Dr. George Huntington firstly described the disease accurately and insightfully, which led to a widespread recognition of the inherited chorea that now bears his name. Huntington disease gene (IT15 locus on chromosome 4p16.3, and encompasses 67 exons with a trinucleotide repeat (CAG in the first exon. The CAG repeat length is highly polymorphic in the population and expanded on at least one chromosome of individuals with HD. Clinically, patient with HD are often onset in adulthood. Juvenile-onset HD is relatively rare. Adult-onset HD patients usually have a CAG expansion from 40 to 55 whereas those with juvenile-onset greater than 60 which are often inherited from the father. We investigated the clinical features of a juvenile-onset case with Huntington disease and dynamic mutation of his family. Methods The CAG repeats of IT15 gene were detected using polymerase chain reaction and capillary electrophoresis in 115 individuals with preliminary diagnosis as Huntington disease. The repeat numbers of some samples carried expanded or intermediate alleles were verified by the pMD18-T vector clone sequencing. Results Fragment analysis showed that one juvenile-onset case presenting with cognitive dysfunction and hypokinesis carried 15/68 CAG repeats of IT15. His father carried 17/37 and mother carried 15/17. Conclusion 1 The juvenile-onset case of HD presented with different clinical features compared with adult-onset cases. The typical signs of adult-onset cases include progressive chorea, rigidity and dementia. The most common sign of juvenile-onset Huntington disease is cognitive decline. 2 The dynamic mutation of IT15 gene expansion of the CAG repeats in the

  15. Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep

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    Bloor, Ian D.; Sébert, Sylvain P.; Saroha, Vivek; Gardner, David S.; Keisler, Duane H.; Budge, Helen; Symonds, Michael E.; Mahajan, Ravi P.

    2013-01-01

    Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is not well established. Using an ovine model of juvenile onset obesity induced by reduced physical activity, we examined the effect of gender on metabolic, circulatory, and related inflammatory and energy-sensing profiles of the major adipose tissu...

  16. The correlation between facial and eyelid demodicosis. Complex therapeutic approaches

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    D. Yu. Maychuk

    2015-01-01

    Full Text Available Aim. To assess the correlation between eyelid and facial demodicosis and to develop an optimal anti-parasitic treatment schedule for posterior blepharitis associated with eyelid demodicosis. Materials and methods. 100 patients with posterior blepharitis associated with eyelid demodicosis were enrolled in the study. The patients were divided into 2 groups depending on Demodex count. Demodex count less than 4 mites was considered normal while Demodex count more than 4 mites was considered pathological. 60 patients with Demodex count more than 4 mites were subdivided into 2 groups. Study group patients (n = 30 received anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage. Control group patients (n = 30 received antiparasitic therapy only. Patients with verified facial demodicosis received dermatological treatment as well. In all patients, integral indices of subjective discomfort and objective signs of posterior blepharitis were measured, Schirmer’s and Norn’s tests were performed, functional state of meibomian glands was evaluated (compressive test. Results. Eyelid demodicosis was associated with facial demodicosis in 48% of patients. In 10%, Demodex count was less than 4 mites. In 38%, Demodex count was more than 4 mites. Skin lesions were revealed in 1% of patients with Demodex count less than 4 mites and in 20% of patients with Demodex count more than 4 mites. Anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage improved functional state of meibomian glands and objective signs of posterior meibomian blepharitis. In 1.5 months after the treatment, Demodex was absent in 80% of study group patients and 56.6% of controls. Conclusion. Stepwise treatment of posterior blepharitis associated with eyelid demodicosis (anti-inflammatory and anti-parasitic therapy, eyelid hygiene is effective and provides prolonged remission. 

  17. The correlation between facial and eyelid demodicosis. Complex therapeutic approaches

    Directory of Open Access Journals (Sweden)

    D. Yu. Maychuk

    2015-03-01

    Full Text Available Aim. To assess the correlation between eyelid and facial demodicosis and to develop an optimal anti-parasitic treatment schedule for posterior blepharitis associated with eyelid demodicosis. Materials and methods. 100 patients with posterior blepharitis associated with eyelid demodicosis were enrolled in the study. The patients were divided into 2 groups depending on Demodex count. Demodex count less than 4 mites was considered normal while Demodex count more than 4 mites was considered pathological. 60 patients with Demodex count more than 4 mites were subdivided into 2 groups. Study group patients (n = 30 received anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage. Control group patients (n = 30 received antiparasitic therapy only. Patients with verified facial demodicosis received dermatological treatment as well. In all patients, integral indices of subjective discomfort and objective signs of posterior blepharitis were measured, Schirmer’s and Norn’s tests were performed, functional state of meibomian glands was evaluated (compressive test. Results. Eyelid demodicosis was associated with facial demodicosis in 48% of patients. In 10%, Demodex count was less than 4 mites. In 38%, Demodex count was more than 4 mites. Skin lesions were revealed in 1% of patients with Demodex count less than 4 mites and in 20% of patients with Demodex count more than 4 mites. Anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage improved functional state of meibomian glands and objective signs of posterior meibomian blepharitis. In 1.5 months after the treatment, Demodex was absent in 80% of study group patients and 56.6% of controls. Conclusion. Stepwise treatment of posterior blepharitis associated with eyelid demodicosis (anti-inflammatory and anti-parasitic therapy, eyelid hygiene is effective and provides prolonged remission. 

  18. Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep.

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    Bloor, Ian D; Sébert, Sylvain P; Saroha, Vivek; Gardner, David S; Keisler, Duane H; Budge, Helen; Symonds, Michael E; Mahajan, Ravi P

    2013-10-01

    Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is not well established. Using an ovine model of juvenile onset obesity induced by reduced physical activity, we examined the effect of gender on metabolic, circulatory, and related inflammatory and energy-sensing profiles of the major adipose tissue depots. Despite a similar increase in fat mass with obesity between genders, males demonstrated a higher storage capacity of lipids within perirenal-abdominal adipocytes and exhibited raised insulin. In contrast, obese females became hypercortisolemic, a response that was positively correlated with central fat mass. Analysis of gene expression in perirenal-abdominal adipose tissue demonstrated the stimulation of inflammatory markers in males, but not females, with obesity. Obese females displayed increased expression of genes involved in the glucocorticoid axis and energy sensing in perirenal-abdominal, but not omental, adipose tissue, indicating a depot-specific mechanism that may be protective from the adverse effects of metabolic dysfunction and inflammation. In conclusion, young males are at a greater risk than females to the onset of comorbidities associated with juvenile-onset obesity. These sex-specific differences in cortisol and adipose tissue could explain the earlier onset of the metabolic-related diseases in males compared with females after obesity.

  19. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis

    DEFF Research Database (Denmark)

    Silverberg, Michael J.; Thorsen, Poul; Lindeberg, Henning

    2003-01-01

    OBJECTIVE: To assess the risk of juvenile-onset recurrent respiratory papillomatosis conferred by a maternal history of genital warts in pregnancy, and to identify additional cofactors such as the method of delivery (cesarean versus vaginal) and procedures or complications during pregnancy. METHODS......: A retrospective cohort design was used to evaluate maternal and infant characteristics associated with respiratory papillomatosis among Danish births between 1974 and 1993. Using data from Danish registries, we identified 3033 births with a maternal history of genital warts during pregnancy. Fifty......-seven respiratory papillomatosis cases were identified by review of medical records from ear, nose, and throat departments. RESULTS: Seven of every 1000 births with a maternal history of genital warts resulted in disease in the offspring, corresponding to a 231.4 (95% confidence interval 135.3, 395.9) times higher...

  20. Accommodative lag and juvenile-onset myopia progression in children wearing refractive correction.

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    Berntsen, David A; Sinnott, Loraine T; Mutti, Donald O; Zadnik, Karla

    2011-05-11

    The relationship between accommodative lag and annual myopia progression was investigated using linear models in 592 myopic children wearing a full refractive correction in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study. The mean (± SD) age and spherical equivalent refractive error at baseline were 10.4 ± 1.8 years and -2.13 ± 1.24 D, respectively. The mean annual progression of myopia was -0.45 ± 0.32 D, and the mean accommodative lag (for a 4-D Badal stimulus) was 1.59 ± 0.63 D. Neither lag at the beginning nor at the end of a yearly progression interval was associated with annual myopia progression (all p ≥ 0.12). These data suggest that foveal hyperopic retinal blur during near viewing may not drive juvenile-onset myopia progression.

  1. HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations

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    B.L. Liphaus

    2007-04-01

    Full Text Available Human leukocyte antigens (HLA DRB1*03 and DRB1*02 have been associated with systemic lupus erythematosus (SLE in Caucasians and black populations. It has been observed that certain HLA alleles show stronger associations with SLE autoantibodies and clinical subsets, although they have rarely been associated with lupus renal histologic class. In the present study, HLA-DRB1 allele correlations with clinical features, autoantibodies and renal histologic class were analyzed in a cohort of racially mixed Brazilian patients with juvenile-onset SLE. HLA-DRB1 typing was carried out by polymerase chain reaction amplification with sequence-specific primers using genomic DNA from 55 children and adolescents fulfilling at least four of the American College of Rheumatology criteria for SLE. Significance was determined by the chi-square test applied to 2 x 2 tables. The HLA-DRB1*15 allele was most frequent in patients with renal, musculoskeletal, cutaneous, hematologic, cardiac, and neuropsychiatric involvement, as well as in patients positive for anti-dsDNA, anti-Sm, anti-U1-RNP, and anti-SSA/Ro antibodies, although an association between HLA alleles and SLE clinical features and autoantibodies could not be observed. The HLA-DRB1*17, HLA-DRB1*10, HLA-DRB1*15, and HLA-DRB1*07 alleles were significantly higher in patients with renal histologic class I, class IIA, class IIB, and class V, respectively. The present results suggest that the contribution of HLA- DRB1 alleles to juvenile-onset SLE could not be related to clinical or serological subsets of the disease, but it may be related to renal histologic classes, especially class I, class II A, class II B, and class V. The latter correlations have not been observed in literature.

  2. Cutaneous xanthomas with concurrent demodicosis and dermatophytosis in a cat.

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    Vogelnest, L J

    2001-07-01

    Multiple cutaneous xanthomas, associated with fasting hyperlipidaemia, are described in a 9-month-old domestic long-haired cat. A severely pruritic, papular, and crusting dermatitis affecting the head and neck, initially diagnosed as lesions of the eosinophilic granuloma complex, progressively developed on the head and pinnae. Pruritus was controlled with administration of prednisolone and chlorambucil. Repeat histological examination confirmed the diagnosis of cutaneous xanthoma and concurrent mild demodicosis. Marked fasting hypercholesterolaemia, hypertriglyceridaemia and transient hyperglycaemia were subsequently confirmed. Treatment for hyperlipidaemia and xanthomas with a low-fat diet (Hill's Feline r/d) and the previously unreported treatment for feline demodicosis of daily oral milbemycin were commenced. Multiple pink, alopecic plaques and papules gradually regressed, however pruritus recurred if immunosuppressive treatment was reduced, and well-demarcated areas of alopecia developed on the head, limbs and trunk, despite negative skin scrapings for demodex mites. Fungal culture of hair samples yielded Microsporum canis. All cutaneous lesions resolved with the addition of griseofulvin to the treatment regimen. Concurrent corneal ulceration and keratoconjunctivitis sicca ultimately resolved with treatment, including topical cyclosporin. Diabetes mellitus developed 6 months after resolution of skin lesions. No cutaneous or ocular abnormalities were present 6 months later with continued low-fat diet and insulin administration, although transient recurrence of papules and pruritus occurred after inadvertent access to a fatty meal. An underlying primary hyperlipidaemia was suspected, causing pruritic xanthomas. This may represent the first report of concurrent cutaneous xanthomas, demodicosis and dermatophytosis in a cat.

  3. Canine demodicosis: a retrospective study of a veterinary hospital population in California, USA (2000-2016).

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    Bowden, Daniel G; Outerbridge, Catherine A; Kissel, Marguerite B; Baron, Jerome N; White, Stephen D

    2017-09-03

    Demodex spp. are cutaneous mites that cause clinical disease when present in increased numbers. There is an association in some dogs with underlying systemic disease or immunosuppressive medications. Retrospective study to document breed predisposition, identify any concurrent diseases or underlying immunosuppressive conditions, and to determine the frequency of demodicosis recurrence after treatment completion. There were 431 dogs with demodicosis presented to a veterinary teaching hospital in California, USA, from 2000 to 2016. Inclusion in this study required a diagnosis of demodicosis based on direct demonstration of the mite. Records were reviewed for signalment, disease history, potential underlying aetiologies, diagnosed concurrent diseases, medications and demodicosis treatment. Analyses were performed to evaluate for potential breed predispositions and because of the large number of dogs with allergic dermatoses, analyses for this diagnosis as a disease associated with demodicosis was also performed. E-mailed surveys and follow-up telephone calls were used to assess for information about disease recurrence. The pit bull terrier group and West Highland white terrier, based on calculated odds ratio, were breeds predisposed to developing demodicosis. For dogs with demodicosis, allergic dermatoses was an associated disease. Relapse or recurrence of disease after treatment was uncommon, affecting 11% of the dogs with long-term follow-up. This study identified, in dogs attending the institution based in California, USA, breed predilections for canine demodicosis and associated concomitant diseases. It also revealed a low occurrence of disease relapse, recurrence or persistence. © 2017 ESVD and ACVD.

  4. Comparison of acetate tape impression with squeezing versus skin scraping for the diagnosis of canine demodicosis.

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    Pereira, A V; Pereira, S A; Gremião, I D F; Campos, M P; Ferreira, A M R

    2012-11-01

    This study compared the sensitivity of acetate tape impression and skin squeezing with that of deep skin scraping for the diagnosis of demodicosis in dogs. Demodex canis was detected in 100% of acetate tape impressions obtained after skin squeezing and in 90% of deep skin scrapings. There was a significant difference (P scraping and is an alternative diagnostic method for canine demodicosis.

  5. Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes

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    Yikun Mou

    2015-01-01

    Full Text Available Background. Ankylosing spondylitis (AS is a common rheumatic disease and is characterized by inflammation of the axial skeleton. HLA-B27 is strongly associated with AS. Juvenile-onset AS (JAS with disease onset before 16 years of age differs from adult-onset AS (AAS in many respects. Objective. To compare the clinical features in JAS with different B27 subtypes and analyze the differences between JAS and AAS. Methods. 145 JAS and 360 AAS patients were included. The demographic data, clinical manifestations, laboratory markers, Bath AS indices, and B27 subtypes were recorded. Results. Peripheral arthritis, enthesitis, BASDAI, ESR, and CRP were significantly higher in JAS patients with HLA-B*2704 than those with B27-negative. Enthesitis and ESR were significantly higher in patients with HLA-B*2705 than those with B27-negative. The onset age of HLA-B*2715 group was much earlier than the other groups. The peripheral arthritis, enthesitis, and hip joint involvement in JAS with HLA-B*2704 were significantly higher than those in AAS with HLA-B*2704. Conclusion. JAS with different B27 subtypes had similar features in most of manifestations; JAS and AAS patients with the same subtype could have distinctive courses. Early diagnosis, hip detection, and control of systemic active inflammation in JAS patients will be helpful for improving the prognosis.

  6. Clinical demodicosis in African buffalo (Syncerus caffer) in the Kruger National Park.

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    Wolhuter, Julie; Bengis, Roy G; Reilly, Brian K; Cross, Paul C

    2009-04-01

    We investigated the relationship between prevalence and severity of clinical signs of Demodex cafferi infection in free-ranging African buffalo (Syncerus caffer) and other factors such as age, sex, pregnancy status, and concomitant infections with bovine tuberculosis (BTB), Rift Valley fever (RVF), and brucellosis (BA). Approximately half of 203 buffalo examined in this study had clinical signs of demodicosis (cutaneous nodules); younger age classes had the highest prevalence and severity of lesions (chi(2)=21.4, df=6, P=0.0015). Nodules were generally limited to the head and neck region, but in severe cases were present over the entire animal. We found no significant association between clinical severity of the Demodex infection and gender, pregnancy status, or infection with BTB, RVF, or BA.

  7. Rosacea-like demodicosis in an HIV-positive child.

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    Barrio, J; Lecona, M; Hernanz, J M; Sánchez, M; Gurbindo, M D; Lázaro, P; Barrio, J L

    1996-01-01

    A second case of rosacea-like demodicosis in an HIV-positive child was seen at our center. No such cases have previously been published. The present case is a 2-year-old boy, the son of an HIV-positive mother, who responded well to oral erythromycin and topical metronidazole. The frequency of rosacea-like eruptions in HIV-negative children is very low. However, the incidence of these eruptions in HIV-positive children may have been underestimated. The pathogenic role of Demodex mites is discussed as well as the possible mechanisms for an exaggerated reaction.

  8. Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus.

    Science.gov (United States)

    Garf, Kamal El; Marzouk, Huda; Farag, Yomna; Rasheed, Laila; Garf, Ayman El

    2015-09-01

    There are scanty data on the prevalence of vitamin D deficiency and its relation to disease activity among patients with juvenile-onset systemic lupus erythematosus (JoSLE) in the Middle East and North Africa, an area known to be endemic for vitamin D deficiency and insufficiency. The aim of this study was, therefore, to study vitamin D status and its relation to disease activity and parameters in Egyptian patients with JoSLE. Serum levels of 25(OH) D3 in 70 JoSLE patients were compared to 40 age-, sex-, and body mass index-matched healthy controls. The 25(OH) D3 was determined by enzyme-linked immunosorbent assay. Information regarding the medical history, clinical symptoms, and signs was registered at the time of serum sampling. Disease activity of SLE was evaluated according to the SLEDAI score. The mean level of serum 25(OH) D3 was 12 ± 3.7 in JoSLE patients compared to 21 ± 3.5 ng/mL in normal controls (p 30 ng/mL. There was no significant correlation between serum levels of 25(OH) D3 and the demographic data, medication used, and some laboratory data of patients with JoSLE. Disease activity score in our patients was insignificantly correlated with serum levels of 25(OH) D3. In spite of vitamin D supplementation in Egyptian JoSLE patients and the presence of vitamin D insufficiency in the control group, there are still significantly lower levels of vitamin D in JoSLE compared to normal controls.

  9. Disease activity, severity, and damage in the UK Juvenile-Onset Systemic Lupus Erythematosus Cohort.

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    Watson, Louise; Leone, Valentina; Pilkington, Clarissa; Tullus, Kjell; Rangaraj, Satyapal; McDonagh, Janet E; Gardner-Medwin, Janet; Wilkinson, Nick; Riley, Phil; Tizard, Jane; Armon, Kate; Sinha, Manish D; Ioannou, Yiannis; Archer, Neil; Bailey, Kathryn; Davidson, Joyce; Baildam, Eileen M; Cleary, Gavin; McCann, Liza J; Beresford, Michael W

    2012-07-01

    The UK Juvenile-Onset Systemic Lupus Erythematosus (JSLE) Cohort Study is a multicenter collaborative network established with the aim of improving the understanding of juvenile SLE. The present study was undertaken to describe the clinical manifestations and disease course in patients with juvenile SLE from this large, national inception cohort. Detailed data on clinical phenotype were collected at baseline and at regular clinic reviews and annual followup assessments in 232 patients from 14 centers across the UK over 4.5 years. Patients with SLE were identified according to the American College of Rheumatology (ACR) SLE classification criteria. The present cohort comprised children with juvenile SLE (n=198) whose diagnosis fulfilled ≥4 of the ACR criteria for SLE. Among patients with juvenile SLE, the female:male sex distribution was 5.6:1 and the median age at diagnosis was 12.6 years (interquartile range 10.4-14.5 years). Male patients were younger than female patients (PLupus Assessment Group disease activity index demonstrated significantly increased frequencies of musculoskeletal (82%), renal (80%), hematologic (91%), immunologic (54%), and neurologic (26%) involvement among the patients over time. A large proportion of the patients (93%) were taking steroids and 24% of the patients required treatment with cyclophosphamide. Disease damage was common, with 28% of the patients having a Systemic Lupus International Collaborating Clinics/ACR damage score of ≥1. The data on these patients from the UK JSLE Cohort Study, comprising one of the largest national inception cohorts of patients with juvenile SLE to date, indicate that severe organ involvement and significant disease activity are primary characteristics in children with juvenile SLE. In addition, accumulation of disease-associated damage could be seen. Copyright © 2012 by the American College of Rheumatology.

  10. Coblation plus photodynamic therapy (PDT) for the treatment of juvenile onset laryngeal papillomatosis: case reports.

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    Zhou, Chengyong; Sun, Baochun; Wang, Feng; Dai, Zhiyao; Han, Zeli; Han, Jiahong; Chen, Maomao; Shen, Yao

    2014-08-29

    In treating juvenile-onset laryngeal papillomatosis, the most difficult aspect is preventing recurrence. After a single treatment, recurrence can begin after as soon as 20 days and the recurrent rate can be higher than 90%. The causes of recurrence include the presence of mucosal cells infected with papilloma virus, which are undetectable with the naked eyes, and surgery-induced infection. Photodynamic therapy (PDT) could effectively solve this problem. Virus-infected cells have a very high metabolic energy for capturing and internalizing the photosensitizer, which, after light stimulation, subsequently induces active oxygen species inside the nucleus, which kill infected cells. The second generation of photosensitizer agents (PA) are locally applied to avoid the intravenous systemic damage caused by first-generation PAs, and this method is widely used for the treatment of genital warts to very good effect. We used the photodynamic method to treat laryngeal papillomatosis in children and obtained significant efficacy. We followed three juvenile subjects with recurrent laryngeal papillomatosis through a course of treatment (each course includes three PDT sessions), with a follow-up after 6 months. The characteristic procedures involve exposing the larynx with a laryngoscope and using low-temperature plasma technology to visualize the tumor resection, as the effects of plasma technology can reduce postoperative laryngeal edema and reduce intraoperative metastasis. PDT was performed during the first surgery, 20 days after and 30 days after surgery. At the 6-month follow-ups, there was no recurrence. This was the world's first successful reported case of the use of PDT treatment for juvenile laryngeal papillomatosis.

  11. The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy.

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    Arsenović, Milica; Pezo, Lato; Vasić, Nebojša; Ćirić, Rodoljub; Stefanović, Milan

    2015-07-01

    The main idea of this research was to evaluate the efficacy of canine demodicosis conventional treatments using mathematical analyses. All available papers published between 1980 and 2014 were used in this study. One hundred six clinical trials enrolling 3414 cases of generalized demodicosis in dogs are studied. Dogs entered in the analysis were only the ones in which the disease occurred naturally, excluding the studies in which transplantation of Demodex canis mites was done from other animals. In conventional acaricide treatments, sorted according to active substances (moxidectin, amitraz, doramectin, ivermectin, and milbemycin oxime), the way of application (spot-on, dips, orally, or subcutaneous), concentration, and interval of application were used as input parameters in mathematical modeling. Data of interest were the treatment outcome, the number of dogs that went into remission, the number of animals not responding to treatment microscopically, the average duration of therapy, the follow-up period, the number of patients with disease recurrence, the number of adverse effects, and the number of animals with side effects. Dogs lost to follow-up or when the treatment was discontinued, due to various reasons not in connection with the therapy protocol, were not considered. Statistical and mathematical analyses were applied for prediction of the drugs' effectiveness. Developed mathematical models showed satisfactorily r (2), higher than 0.87. Good evidence for recommending the use of milbemycin oxime PO (0.5 mg/kg, daily) and moxidectin spot-on (Advocate®, Bayer) weekly is found. A bit less effective therapies were based on ivermectin PO (0.5 mg/kg, daily), moxidectin PO (0.35 mg/kg, daily), and amitraz dips (0.05 % solution, weekly), respectively. It is important to keep in mind that Advocate® is recommended by the manufacturer for use in milder cases.

  12. [First report of demodicosis in goats in the Czech Republic].

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    Fleischer, P; Lukesová, D; Skrivánek, M; Hofírek, B; Stursa, I

    1996-09-01

    The first case of demodectic (Acari: Demodecidae) mange in the Czech Republic was diagnosed in a domestic White Shorthaired goat hospitalized in our clinic. A total of 128 solid protruding nodules, similar in size to lens or pea, were found on lateral parts of the neck and trunk and on proximal part sof the limbs. A pasty, creamy mass containing immature and adult mites could be pressed out of the nodules. Parasitological examinations identified the mites as Demodex caprae Railliet, 1895 (Fig. 1). Antiparasitic treatment was started with the pyrethroid deltamethrine (Butox 7.5 Pour On, Roussel Uclaf) although demodectic mange is not given in the spectrum of its applications. Ten ml of the drug were poured onto the back of the animal twice within an interval of 7 days. The next drug tested was another pyrethroid, Neostomosan sol. ad us. vet. (Sanofi Santé Animale) containing tetramethrine and transmix as the effective ingredients and recommended by the manufacturer for the treatment of canine and feline demodicosis. The animal was bathed twice within an interval of 14 days in a 1 : 400 dilution as recommended by the manufacturer. The mites survived the treatments with both drugs and their motility was not affected. The size of nine of the nodules (4.5 to 6.8 mm), measured before and after the treatments, remained unchanged. The third drug tested was amitraz (Taktic, Hoechst) known to be effective against canine demodicosis (Ectodex, Hoechst). Seven baths with 10-day intervals in the drug diluted 1 : 400 resulted in the decrease of the number of nodules to 83 (by 35.2%). The diameters of 7 of the measured nodules diminished by approx. 1.6 mm. No movements of the mites were observed on Day 56 after the treatment, but the immature stages probably survived because new nodules and allergy developed after the patient had been released from the clinic. The unsatisfactory effect of amitraz can be explained by the limited penetration of the drug into the nodules surrounded

  13. Enhanced Apoptosis of Monocytes from Complication-Free Juvenile-Onset Diabetes Mellitus Type 1 May Be Ameliorated by TNF-α Inhibitors

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    Jolanta Myśliwska

    2014-01-01

    Full Text Available Diabetes mellitus type 1 is associated with an enhanced apoptosis of different cells and tissues, accelerating occurrence of diabetic microvascular complications. The aim of our study was to determine spontaneous apoptotic potential of the monocyte subsets in juvenile-onset complication-free diabetes mellitus type 1 and to compare them with the corresponding values of the healthy. Moreover, we wanted to assess effects of TNF-R1 blocking agents and those of general TNF-α blocker (Infliximab on spontaneous apoptosis of monocytes. Sixty randomly selected DM1 patients (14.5 ± 3.2 years and 30 healthy (13.5 ± 2.8 years volunteers were enrolled in the study. Our results indicate that three monocyte subsets are distinguishable in the groups of young diabetic patients and the healthy, similarly to in the blood of adults. DM1 patients were characterized by higher values of apoptotic monocytes than the healthy. The manipulation with drugs inhibiting TNF-R1 expression diminished the pool of CD16+ apoptotic monocytes. Infliximab reduced the apoptotic CD16− cells. In conclusion, diabetes mellitus type 1 is associated with greater apoptosis of three monocyte subsets which may contribute to the development of microvascular complications. TNF-α modifiers appear to ameliorate monocyte apoptosis. They may be useful for controlling excessive monocyte apoptosis in diabetic patients.

  14. Prevalence of ocular demodicosis among patients at Tertiary Care Center, Bangkok, Thailand

    Science.gov (United States)

    Kasetsuwan, Ngamjit; Kositphipat, Kitchaporn; Busayarat, Mathu; Threekhan, Pawanrat; Preativatanyou, Kanok; Phumee, Atchara; Siriyasatien, Padet

    2017-01-01

    AIM To determine the prevalence of ocular demodicosis by both microscopic examination and molecular detection among patients at King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok. METHODS One hundred individuals were enrolled in the study and were divided into five age groups. The meibomian gland dysfunction (MGD) score and qualities of cylindrical dandruff (CD) were also determined. Demodex mite infestations of eyelash samples were screened by both microscopic examination and semi-nested polymerase chain reaction (PCR). RESULTS The prevalence of ocular demodicosis as determined by microscopic examination was 42% [Demodex folliculorum (D. folliculorum) 41% and Demodex brevis (D. brevis) 1%]. Among patients who had ocular Demodex infestation, 69% have CD and had an average MGD score of 4; in patients without demodicosis, 15.5% had CD and had an average MGD score of 4.12. Prevalence of ocular demodicosis as determined by semi-nested PCR was 79% (D. folliculorum 78% and D. brevis 1%). CONCLUSION This is the first report on the prevalence of ocular demodicosis in Thailand. Patients with CD also had Demodex mites present. Semi-nested PCR is better than microscopy for Demodex infestation detection. An extensive survey with more representative samples is required to determine the prevalence in the country. PMID:28149788

  15. An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.

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    Kari J Ekenstedt

    2014-10-01

    Full Text Available An inherited polyneuropathy (PN observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed PN, characterized by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as inspiratory stridor and dyspnea. We mapped a PN locus in Leonbergers to a 250 kb region on canine chromosome 16 (Praw = 1.16×10-10, Pgenome, corrected = 0.006 utilizing a high-density SNP array. Within this interval is the ARHGEF10 gene, a member of the rho family of GTPases known to be involved in neuronal growth and axonal migration, and implicated in human hypomyelination. ARHGEF10 sequencing identified a 10 bp deletion in affected dogs that removes four nucleotides from the 3'-end of exon 17 and six nucleotides from the 5'-end of intron 17 (c.1955_1958+6delCACGGTGAGC. This eliminates the 3'-splice junction of exon 17, creates an alternate splice site immediately downstream in which the processed mRNA contains a frame shift, and generates a premature stop codon predicted to truncate approximately 50% of the protein. Homozygosity for the deletion was highly associated with the severe juvenile-onset PN phenotype in both Leonberger and Saint Bernard dogs. The overall clinical picture of PN in these breeds, and the effects of sex and heterozygosity of the ARHGEF10 deletion, are less clear due to the likely presence of other forms of PN with variable ages of onset and severity of clinical signs. This is the first documented severe polyneuropathy associated with a mutation in ARHGEF10 in any species.

  16. Demodicose bovina no Estado da Paraíba Bovine demodicosis in the state of Paraíba, northeastern Brazil

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    João Luiz H. Faccini

    2004-09-01

    Full Text Available Casos de demodicose bovina foram observados em um rebanho da raça Sindhi no período de dezembro 1989 a janeiro 1992. Ambas as formas, localizada e generalizada, foram diagnosticadas. Este é o primeiro relato da forma generalizada no Brasil. Nos dois primeiros anos, a demodicose foi diagnosticada somente em animais Cases of bovine demodicosis caused by Demodex bovis were reported in a Sindhi herd from December 1989 to January 1992. Both localized and generalized forms were diagnosed. This is the first report of the generalized form in Brazil. In the first two years, demodicosis was diagnosed only in cattle 2 years old, respectively. Clinical signs varied from a few small nodules to a thickened skin with soft large nodules in the localized and generalized forms, respectively. Main microscopic features of the nodules in the generalized form consisted of acanthosis with hyperqueratosis, chronic sebaceous adenitis, subcutaneous muscular necrosis, focal cellular degeneration of the epidermis basal layer and presence of large number of mites inside the lumen of dilated hair follicles. In addition, a chronic perifoliculitis was observed, characterized by lymphoplasmocytic infiltrate which also contained macrophages and neutrophils. It is suggested that poor nutrition and stress due to prolonged drought probably contributed to the increase of susceptibility of the herd to mite infestation.

  17. Demodicosis in Chamois ( Rupicapra rupicapra subsp. rupicapra) in the Italian Alps, 2013-14.

    Science.gov (United States)

    Salvadori, Claudia; Formenti, Nicoletta; Trogu, Tiziana; Lanfranchi, Paolo; Papini, Roberto A; Poli, Alessandro

    2016-04-28

    We report demodicosis in five alpine chamois ( Rupicapra rupicapra subsp. rupicapra) from the Italian Alps that showed moderate crusts on the head and dorsal aspect of the trunk. We detected intramural folliculitis, moderate dermatitis, and T-lymphocytes and macrophages associated with Demodex spp. in follicles and sebaceous glands.

  18. EULAR/PReS standards and recommendations for the transitional care of young people with juvenile-onset rheumatic diseases.

    Science.gov (United States)

    Foster, Helen E; Minden, Kirsten; Clemente, Daniel; Leon, Leticia; McDonagh, Janet E; Kamphuis, Sylvia; Berggren, Karin; van Pelt, Philomine; Wouters, Carine; Waite-Jones, Jennifer; Tattersall, Rachel; Wyllie, Ruth; Stones, Simon R; Martini, Alberto; Constantin, Tamas; Schalm, Susanne; Fidanci, Berna; Erer, Burak; Dermikaya, Erkan; Ozen, Seza; Carmona, Loreto

    2017-04-01

    To develop standards and recommendations for transitional care for young people (YP) with juvenile-onset rheumatic and musculoskeletal diseases (jRMD). The consensus process involved the following: (1) establishing an international expert panel to include patients and representatives from multidisciplinary teams in adult and paediatric rheumatology; (2) a systematic review of published models of transitional care in jRMDs, potential standards and recommendations, strategies for implementation and tools to evaluate services and outcomes; (3) setting the framework, developing the process map and generating a first draft of standards and recommendations; (4) further iteration of recommendations; (5) establishing consensus recommendations with Delphi methodology and (6) establishing standards and quality indicators. The final consensus derived 12 specific recommendations for YP with jRMD focused on transitional care. These included: high-quality, multidisciplinary care starting in early adolescence; the integral role of a transition co-ordinator; transition policies and protocols; efficient communications; transfer documentation; an open electronic-based platform to access resources; appropriate training for paediatric and adult healthcare teams; secure funding to continue treatments and services into adult rheumatology and the need for increased evidence to inform best practice. These consensus-based recommendations inform strategies to reach optimal outcomes in transitional care for YP with jRMD based on available evidence and expert opinion. They need to be implemented in the context of individual countries, healthcare systems and regulatory frameworks. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  19. Juvenile Onset HD

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    ... Staff Directory Annual Convention Board of Trustees National Youth Alliance Advocacy Support Groups Social Workers Scientific Advisory Board News Financials Strategic Plan Careers Shop Locate Resources Media Center What is HD? What is HD? Stages ...

  20. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis.

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    Christian Ulrich Huebbers

    Full Text Available Juvenile-onset recurrent respiratory papillomatosis (RRP is associated with low risk human papillomavirus (HPV types 6 and 11. Malignant transformation has been reported solely for HPV11-associated RRP in 2-4% of all RRP-cases, but not for HPV6. The molecular mechanisms in the carcinogenesis of low risk HPV-associated cancers are to date unknown. We report of a female patient, who presented with a laryngeal carcinoma at the age of 24 years. She had a history of juvenile-onset RRP with an onset at the age of three and subsequently several hundred surgical interventions due to multiple recurrences of RRP. Polymerase chain reaction (PCR or bead-based hybridization followed by direct sequencing identified HPV6 in tissue sections of previous papilloma and the carcinoma. P16(INK4A, p53 and pRb immunostainings were negative in all lesions. HPV6 specific fluorescence in situ hybridization (FISH revealed nuclear staining suggesting episomal virus in the papilloma and a single integration site in the carcinoma. Integration-specific amplification of papillomavirus oncogene transcripts PCR (APOT-PCR showed integration in the aldo-keto reductase 1C3 gene (AKR1C3 on chromosome 10p15.1. ArrayCGH detected loss of the other gene copy as part of a deletion at 10p14-p15.2. Western blot analysis and immunohistochemistry of the protein AKR1C3 showed a marked reduction of its expression in the carcinoma. In conclusion, we identified a novel molecular mechanism underlying a first case of HPV6-associated laryngeal carcinoma in juvenile-onset RRP, i.e. that HPV6 integration in the AKR1C3 gene resulted in loss of its expression. Alterations of AKR1C gene expression have previously been implicated in the tumorigenesis of other (HPV-related malignancies.

  1. Pathogenic Variant in ACTB, p.Arg183Trp, Causes Juvenile-Onset Dystonia, Hearing Loss, and Developmental Delay without Midline Malformation

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    Erin Conboy

    2017-01-01

    Full Text Available ACTB encodes the β-actin, and pathogenic variations in this gene have typically been associated with Baraitser-Winter cerebrofrontofacial syndrome, a congenital malformation syndrome characterized by short stature, craniofacial anomalies, and cerebral anomalies. Here, we describe the third case with the p.Arg183Trp variant in ACTB causing juvenile-onset dystonia. Our patient has severe, intractable dystonia, developmental delay, and sensorineural hearing loss, besides hyperintensities in the caudate nuclei and putamen on the brain MRI, which is a distinct but overlapping phenotype with the previously reported case of identical twins with the same alteration in ACTB.

  2. Juvenile onset systemic lupus erythematosus: a possible role for vitamin D in disease status and bone health.

    Science.gov (United States)

    Casella, C B; Seguro, L P C; Takayama, L; Medeiros, D; Bonfa, E; Pereira, R M R

    2012-10-01

    In juvenile onset systemic lupus erythematosus (JoSLE), evidence for the association between vitamin D status, lupus activity, and bone health is very limited and not conclusive. The aim of this study was, therefore, to assess in JoSLE patients the possible relevance of vitamin D deficiency in disease and bone parameters. Fifty-seven JoSLE patients were initially compared to 37 age, race and body mass index (BMI) -matched healthy controls. The serum concentration of 25 hydroxyvitamin D (25OHD) was determined by radioimmunoassay. Patients with 25OHD deficiency (≤20 ng/mL) were compared to those with levels >20 ng/mL. Disease activity was evaluated by SLE Disease Activity Index (SLEDAI). Bone mineral density (BMD) and body composition (BC) were measured using dual-energy X-ray absorptiometry (DXA). 25OHD levels were similar in patients and controls (21.44 ± 7.91 vs 22.54 ± 8.25 ng/mL, p = 0.519), regardless of supplementation (65% of patients and none in controls). Thirty-one patients with 25OHD deficiency (≤20 ng/mL) were further compared to the 26 JoSLE patients with levels >20 ng/mL. These two groups were well-balanced regarding vitamin D confounding variables: age (p = 0.100), ethnicity (p = 1.000), BMI (p = 0.911), season (p = 0.502), frequency of vitamin D supplementation (p = 0.587), creatinine (p = 0.751), renal involvement (p = 0.597), fat mass (p = 0.764), lean mass (p = 0.549), previous/current use of glucocorticoids(GC) (p = 1.0), immunosuppressors (p = 0.765), and mean current daily dose of GC (p = 0.345). Patients with vitamin D deficiency had higher SLEDAI (3.35 ± 4.35 vs 1.00 ± 2.48, p = 0.018), lower C4 levels (12.79 ± 6.78 vs 18.38 ± 12.24 mg/dL, p = 0.038), lower spine BMD (0.798 ± 0.148 vs 0.880 ± 0.127 g/cm(2), p = 0.037) and whole body BMD (0.962 ± 0.109 vs 1.027 ± 0.098 g/cm(2), p = 0.024). JoSLE vitamin D

  3. A case report of the management of demodicosis in the golden hamster.

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    Hasegawa, T

    1995-04-01

    A 1.6 year-old male golden hamster was presented with alopecia on the back. The animal's physical condition was slightly below normal, and moderate pruritus was observed. Examination of skin scraping revealed mites identified as Demodex sp. Initially, combined therapy using 1% of selenium sulfide shampoo and a topical application of 0.013% amitraz was carried out, although this was not completely successful. Repeated use of 0.017% coumaphos was effective in achieving a complete cure of the alopecia associated with demodicosis. No adverse side effects were recognized during the treatment of this case.

  4. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis

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    Beugnet Frédéric

    2016-01-01

    Full Text Available The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard®, Merial administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate®, Bayer. Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.

  5. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis.

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    Beugnet, Frédéric; Halos, Lénaïg; Larsen, Diane; de Vos, Christa

    2016-01-01

    The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard(®), Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate(®), Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.

  6. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis

    Science.gov (United States)

    Beugnet, Frédéric; Halos, Lénaïg; Larsen, Diane; de Vos, Christa

    2016-01-01

    The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard®, Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate®, Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period. PMID:27012161

  7. Clinical and genetic study of a juvenile-onset Huntington disease%少年型亨廷顿病临床与基因突变分析

    Institute of Scientific and Technical Information of China (English)

    郝莹; 陈园园; 顾卫红; 王国相; 马惠姿; 李丽林; 王康; 金淼; 段晓慧

    2012-01-01

    Background Huntington's disease (HD) is an autosomal dominant hereditary progressive neurodegenerative disorder with a distinct phenotype characterized by chorea, dementia, cognitive and affective impairment. There are selective neural cell loss and atrophy in the caudate and putamen. Dr. George Huntington firstly described the disease accurately and insightfully, which led to a widespread recognition of the inherited chorea that now bears his name. Huntington disease gene (1T15) locus on chromosome 4p16.3, and encompasses 67 exons with a trinucleotide repeat (CAG) in the first exon.The CAG repeat length is highly polymorphic in the population and expanded on at least one chromosome of individuals with HD. Clinically, patient with HD are often onset in adulthood. Juvenile - onset HD is relatively rare. Adult-onset HD patients usually have a CAG expansion from 40 to 55 whereas those with juvenile - onset greater than 60 which are often inherited from the father. We investigated the clinical features of a juvenile-onset case with Huntington disease and dynamic mutation of his family. Methods The CAG repeats of 1T15 gene were detected using polymerase chain reaction and capillary electrophoresis in 115 individuals with preliminary diagnosis as Huntington disease. The repeat numbers of some samples carried expanded or intermediate alleles were verified by the pMD18-T vector clone sequencing. Results Fragment analysis showed that one juvenile - onset case presenting with cognitive dysfunction and hypokinesis carried 15/68 CAG repeats of 1T15. His father carried 17/37 and mother carried 15/17. Conclusion 1) The juvenile-onset case of HD presented with different clinical features compared with adult-onset cases. The typical signs of adult-onset cases include progressive chorea, rigidity and dementia. The most common sign of juvenile-onset Huntington disease is cognitive decline. 2) The dynamic mutation of IT15 gene expansion of the CAG repeats in the intergenerational

  8. Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

    Directory of Open Access Journals (Sweden)

    Clarissa P. Souza

    2014-11-01

    Full Text Available The objective of the study was to evaluate the efficacy of pour-on formulations of fluazuron and ivermectin in different therapeutic protocols for treatment of demodicosis by means of quantifying mites with skin scraping, histological and clinical evaluation in dogs. Eighteen dogs with skin scrapings positive for Demodex canis were evaluated, divided into three groups. All the animals were treated every 14 days, completing 6 treatments for each animal (days 0, 14, 28, 42, 56 and 70. In group 1, pour-on 2.5% fluazuron was used at the dose of 20mg/kg; in the group 2 pour-on 2.5% fluazuron at a dose of 20 mg/kg in association with pour-on 0.5% ivermectin at the dose of 0.6mg/kg; and in group 3, pour-on 0.5% ivermectin alone was used, at the dose of 0.6mg/kg. The treatment was evaluated and monitored through skin scrapings and clinical follow-up of the lesions every 14 days for 84 days, and through histopathological examination at the end of each treatment protocol. The success rate was defined as the percentage of dogs in each group that had negative skin scrapings after the treatment: this was 16.67% for group 1, and 50% for groups 2 and 3. The reduction in mite counts reached effectiveness of 67.66%, 88.99% and 84.29% for groups 1, 2 and 3 respectively. The Wilcoxon test showed that there was a significant difference between the number of mites before and after treatment in groups 2 and 3. The histopathological examination revealed that only group 1 showed no significant difference in the intensity of infestation between days 0 and 84. Clinically, there was no significant difference between the evaluation before and after treatment in the three groups. pour-on 2.5% fluazuron and pour-on 0.5% ivermectin were not effective for treating canine demodicosis, either in association or as single therapy, when applied every 14 days for a period of 70 days. Quantification of mites using skin scrapings and histological evaluation proved to be ineffective

  9. Zinc transporter-8 autoantibodies can replace IA-2 autoantibodies as a serological marker for juvenile onset type 1 diabetes in India

    Directory of Open Access Journals (Sweden)

    C Shivaprasad

    2014-01-01

    Full Text Available Introduction: Zinc transporter-8 (ZnT8 is an islet cell secretory granule membrane protein recently identified as an autoantigen in type 1 diabetes (T1D. The aim of this study was to estimate the prevalence of antibodies to ZnT8 (ZnT8A in juvenile onset T1D and to determine the utility of ZnT8A as an independent marker of autoimmunity either alone in antibody-negative subjects or in conjunction with glutamic acid decarboxylase (GAD and insulinoma-2 antigen antibodies (GADA and IA2A. Research Design: ZnT8A, GADA, and IA2A were measured in sera of consecutive T1D patients (n = 88, age range 2-18 years within 4 years of diagnosis and 88 sex-matched controls. Results: The prevalences of GADA, ZnT8a, and IA2A were 64.7%, 31.8% and 19.3%, respectively. In newly diagnosed patients, the frequency of ZnT8A was 45%. ZnT8A were positive in 26% of patients negative for both GADA and IA2A. IA2A were positive only in two patients who were negative for other two antibodies. Combined use of ZnT8A and GADA could detect 97% of antibody positive patients. In receiver operating characteristic (ROC analysis, the performances of GADA and ZnT8As were better than that of IA2A; and AUCs of GADA, ZnT8A, and IA2A for the prediction of T1D were 0.8, 0.65, and 0.59, respectively. Conclusions: ZnT8A complements GADA and increases the diagnostic sensitivity for detection of autoimmunity in juvenile-onset T1D. Inclusion of ZnT8A increases the proportion of patients with antibody positivity to nearly 80%. ZnT8A can replace IA2A as a serological marker for autoimmunity in Indian T1D patients without loss of sensitivity and specificity.

  10. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.

    Science.gov (United States)

    Andresen, J Michael; Gayán, Javier; Djoussé, Luc; Roberts, Simone; Brocklebank, Denise; Cherny, Stacey S; Cardon, Lon R; Gusella, James F; MacDonald, Marcy E; Myers, Richard H; Housman, David E; Wexler, Nancy S

    2007-05-01

    Age of onset for Huntington's disease (HD) varies inversely with the length of the disease-causing CAG repeat expansion in the HD gene. A simple exponential regression model yielded adjusted R-squared values of 0.728 in a large set of Venezuelan kindreds and 0.642 in a North American, European, and Australian sample (the HD MAPS cohort). We present evidence that a two-segment exponential regression curve provides a significantly better fit than the simple exponential regression. A plot of natural log-transformed age of onset against CAG repeat length reveals this segmental relationship. This two-segment exponential regression on age of onset data increases the adjusted R-squared values by 0.012 in the Venezuelan kindreds and by 0.035 in the HD MAPS cohort. Although the amount of additional variance explained by the segmental regression approach is modest, the two slopes of the two-segment regression are significantly different from each other in both the Venezuelan kindreds [F(2, 439) = 11.13, P= 2 x 10(-5)] and in the HD MAPS cohort [F(2, 688) = 38.27, P= 2 x 10(-16)]. In both populations, the influence of each CAG repeat on age of onset appears to be stronger in the adult-onset range of CAG repeats than in the juvenile-onset range.

  11. 幼年发病型脊柱关节病的临床特征%Clinical characters of juvenile onset spondyloarthropathies

    Institute of Scientific and Technical Information of China (English)

    张江林; 黄烽

    2001-01-01

    目的 提高对幼年发病型脊柱关节病(JSpA)的认识。方法 分析190例JSpA患者的临床、实验室及放射学资料,并对幼年发病关节炎的诊断、分类和鉴别进行讨论。结果 190例JSpA中,男性163例,女性27例,男女之比为6∶1,发病年龄3~16岁,平均(12±3)岁,8岁后发病175例,占92.1%;157例(82.6%)患者首先出现的是外周关节炎,23例(12.1%)以腰背痛为第一症状,病程中共有187例(98.4%)的患者出现了外周关节炎,123例(64.7%)患者有或有过腰背疼痛史,外周关节炎与腰背疼痛出现的时间间隔,从同时发生到间隔20年,平均3.2年。67例(35.3%)有肌腱端炎的表现,20例(10.5%)腊肠指(趾),9例虹膜炎。HLA-B27的阳性率为87.9%,76.0%有X线证实的骶髂关节炎。在190例患者中,106例患者确诊幼年强直性脊柱炎(JAS),此组患者平均病程6.3年,明显长于JSpA组(P<0.01)。结论 JSpA的概念有助于提高对儿童关节炎的认识,半数以上JSpA患者约在发病6.3年后发展为幼年强直性脊柱炎。%Objective To better understand the clinical characters of juvenile onset spondyloarthropa-thies (JSpA).Methods The clinical and laboratory data of 190 in-patients with JSpA were analyzed and the diagnosis,classification and differentiation of juvenile onset arthritis were discussed.Results Among these 190 patients,163 were male,with a male to female ratio 6∶1.Of them 92.1% had the disease after the age of 8.Peak of age at onset was 12 to 15 years;157(82.6%) patients had peripheral arthritis and only 23(12.1%) patients felt low back pain at onset.During the disease course, peripheral arthritis was found in 187(98.4%) patients and the history of low back pain or buttock pain was recorded in 123(64.7%).The interval between peripheral arthritis and low back pain was from 0 to 20 years,with an average of (3.2±4.5)years.Extra-articular features including enthesitis in 67

  12. Relative size of the eye and orbit: an evolutionary and craniofacial constraint model for examining the etiology and disparate incidence of juvenile-onset myopia in humans.

    Science.gov (United States)

    Masters, Michael P

    2012-05-01

    within the confines of the orbital walls. The results of this study indicate that future research examining the etiology of juvenile-onset myopia, and particularly its correlation with ancestry, sex, age, and intelligence, should consider how the eye interacts with the matrix of structural and functional components of the skull during both ontogenetic and evolutionary morphogenesis.

  13. 青少年开角型青光眼临床表型及遗传学特征%Clinical and genetic characteristics of primary juvenile-onset open-angle glaucoma

    Institute of Scientific and Technical Information of China (English)

    刘铁城

    2014-01-01

    青少年开角型青光眼(juvenile-onset open-angle glaucoma,JOAG)是常染色体显性遗传性疾病,具有发病年龄早、眼压高和进展快等特点.本文回顾了JOAG的临床表型、相关基因及功能,为建立基因型和表型之间的联系,为探讨青光眼的发病机制提供帮助.

  14. Two Consecutive Standardized Skin Surface Biopsies: An Improved Sampling Method to Evaluate Demodex Density as a Diagnostic Tool for Rosacea and Demodicosis.

    Science.gov (United States)

    Forton, Fabienne M N; De Maertelaer, Viviane

    2017-02-08

    Diagnosing papulopustular rosacea is not always straightforward; no specific diagnostic test is currently available. A high density of Demodex mites is consistently observed in this condition. This retrospective study assesses an improved method for evaluating Demodex density among 1,044 patients presenting to our dermatology practice. The skin was cleaned with ether and Demodex densities were measured in 2 consecutive standardized skin surface biopsies taken from the same site. Mean densities in patients with rosacea and demodicosis were much higher than those in healthy controls and patients with other facial dermatoses. The optimal cut-off values for the 2 biopsies were combined and the resultant criterion (presence of a first biopsy density rosacea or demodicosis with a sensitivity of 98.7% and specificity of 95.5%, making this a valuable diagnostic tool for dermatologists in routine clinical practice.

  15. Intergeneration CAG expansion in a Wuhan juvenile-onset Huntingto ndisease family%武汉地区CAG扩增突变致青少年发病的亨廷顿舞蹈病的家系分析

    Institute of Scientific and Technical Information of China (English)

    刘媛; 沈滟; 李和; 王慧; 杨真荣; 陈燕; 唐艳平

    2007-01-01

    目的 对青少年发病的亨廷顿舞蹈病(Huntington disease)家系进行致病IT15基因早期诊断分析,为家系成员提供遗传咨询,并为后续的HD发病机制及实验治疗研究提供依据.方法 按照知情同意原则抽取家系成员外周血,提取基因组DNA,采用改良的降落PCR方法扩增IT15基因致病区域,DNA测序检测异常等位基因(CAG)n三核苷酸重复次数.结果 在该家系三代25名成员中,共发现8名致病IT15基因携带者,其中,Ⅲ10、Ⅲ12、Ⅲ14、Ⅳ3和Ⅴ2 CAG三核苷酸的拷贝数均为48,Ⅳ11和Ⅳ12均为(CAG)67,Ⅳ14为(CAG)63,而对照组35名正常人的CAG三核苷酸的拷贝数为8-25,两者之间没有重叠.结论 家系中第四代致病基因携带者Ⅳ14与第三代患者Ⅲ10比较,CAG三核苷酸重复次数增加15次,即本家系IT15基因在传递过程中发生了扩增突变.同时,扩增突变导致该家系出现青少年发病及遗传早现现象.%Objective To make early diagnosis of IT15 gene mutation in a Wuhan juvenile-onset Huntington disease (HD)family, for providing them with genetic counseling, and making preparation for the further research on pathogenesis and experimental therapy of HD. Methods According to the principle of informed consent, we extracted genomic DNA from peripheral blood samples and carried genetic diagnosis of pathogenic exon 1 of IT15 gene by modified touchdown PCR and DNA sequencing methods. Results Eight of twenty-five family members carried abnormal allele: Ⅲ10, Ⅲ12, Ⅲ14, Ⅳ3,and Ⅴ2 carried (CAG) 48, Ⅳ11 and Ⅳ12 carried (CAG) 67, and Ⅳ14 carried (CAG) 63, in contrast with the 8-25 CAG trinucleotides in the members of control group. Ⅳ14 carried 15 more CAG trinucleotides than her father Ⅲ10. Conclusion The results definitely confirm the diagnosis of HD and indicate the CAG trinucleotide repeat expansion of IT15 gene in this HD family.In addition, CAG expansion results in juvenile-onset and anticipation (characterized

  16. The analysis of the risk factors for sacroiliac joint damage in juvenile-onset spondyloarthropathy%212例少年脊柱关节病骶髂关节损害相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    单鸣凤; 郭君; 陈鸿健

    2012-01-01

    目的:探讨少年脊柱关节病(juvenile-onset spondyloarthropathy,JSpA)患者出现骶髂关节损害的相关危险因素,为选择恰当的治疗方案提供依据.方法:对212例JSpA患者的人口学因素、遗传学因素、受累部位、各个实验室指标等进行分析.将患者按照年龄段(≤11岁及12~16岁)分为两组.分别采用Logistic回归的方法进行分析,筛选出JSpA出现骶髂关节损害的相关发病因素.结果:本组212例患者中有骶髂关节损害者124例,占58.5%.单因素分析显示多个因素在骶髂关节损害中有统计学意义;多因素Logistic逐步回归分析显示病程、起病时外周关节炎尤其是下肢大关节、持续肌腱端炎、HLA-B27阳性、家族史是JSpA并发骶髂关节损害的相关危险因素.结论:JSpA患者出现骶髂关节损害的发生率较高,与多种因素有关,当患者出现这些危险因素时,应早期积极干预治疗,定期检查骶髂关节MRI,减轻或延缓病情的进展.%Objective:To investigate the risk factors of sacroiliac joint damage in patients with juvenile-onset spondyloarthropathy (JSpA),and to provide reference for the selection of appropriate treatment strategy. Methods:To analysis the clinical data of 212 cases of JSpA,including demographic factors(sex,age) .genetic factors,the affected area,laboratories indicators. Patients were divided into two groups according to age (≤ 11 years old and 12~16 years old). Using the Logistic regression to filter out the risk factors of sacroiliac joint damage in patients with JSpA. Results:Out of the 212 cases, 124 (58.5%) patients suffered from sacroiliac joint damage. Single factor analysis showed that a number of factors were related to sacroiliac joint damage. Logistic regression analysis showed that the course of disease, at the onset of peripheral arthritis, particularly the large joints of lower limbs, tendon-sustained inflammation and HLA-B27-positive, family history were the risk

  17. Increased Fas and Bcl-2 Expression on Peripheral Blood T and B Lymphocytes from Juvenile-Onset Systemic Lupus Erythematosus, but not from Juvenile Rheumatoid Arthritis and Juvenile Dermatomyositis

    Directory of Open Access Journals (Sweden)

    Bernadete L. Liphaus

    2006-01-01

    Full Text Available Defective regulation of apoptosis may play a role in the development of autoimmune diseases. Fas and Bcl-2 proteins are involved in the control of apoptosis. The aims of this study were to determine the expression of Fas antigen and Bcl-2 protein on peripheral blood T and B lymphocytes from patients with juvenile-onset systemic lupus erythematosus (JSLE, juvenile rheumatoid arthritis (JRA and juvenile dermatomyositis (JDM. Thirty-eight patients with JSLE, 19 patients with JRA, 10 patients with JDM and 25 healthy controls entered the study. Freshly isolated peripheral blood mononuclear cells (PBMC were stained for lymphocyte markers CD3, CD4, CD8, CD19 and for Fas and Bcl-2 molecules. Expressions were measured by three-color flow cytometry. Statistical analysis was performed using Kruskal–Wallis test. Percentages of freshly isolated T lymphocytes positively stained for Fas protein from JSLE patients were significantly increased compared to healthy controls, patients with JRA and patients with JDM. Percentages of B lymphocytes positive for Fas from JSLE patients were higher than healthy controls and JRA patients. In addition, Fas expression on T cells from patients with JRA was increased compared to JDM patients. Otherwise, Fas expression on T and B cells from JRA and JDM patients were similar to healthy controls. MFI of Bcl-2 positive T lymphocytes from JSLE patients were significantly increased compared to healthy controls and JRA patients. MFI of Bcl-2 protein on B lymphocytes from JSLE patients was similar to healthy controls and patients with JRA and JDM. Bcl-2 expression did not differ between JRA and JDM patients and healthy controls. In conclusion, increased expression of Fas and Bcl-2 proteins observed in circulating T and B lymphocytes from patients with JSLE, but not from patients with JRA and JDM, suggests that abnormalities of apoptosis may be related to the pathogenesis of JSLE and probably are not a result of chronic inflammation.

  18. Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis.

    Science.gov (United States)

    Liphaus, Bernadete L; Kiss, Maria H B; Carrasco, Solange; Goldenstein-Schainberg, Claudia

    2006-01-01

    Defective regulation of apoptosis may play a role in the development of autoimmune diseases. Fas and Bcl-2 proteins are involved in the control of apoptosis. The aims of this study were to determine the expression of Fas antigen and Bcl-2 protein on peripheral blood T and B lymphocytes from patients with juvenile-onset systemic lupus erythematosus (JSLE), juvenile rheumatoid arthritis (JRA) and juvenile dermatomyositis (JDM). Thirty-eight patients with JSLE, 19 patients with JRA, 10 patients with JDM and 25 healthy controls entered the study. Freshly isolated peripheral blood mononuclear cells (PBMC) were stained for lymphocyte markers CD3, CD4, CD8, CD19 and for Fas and Bcl-2 molecules. Expressions were measured by three-color flow cytometry. Statistical analysis was performed using Kruskal-Wallis test. Percentages of freshly isolated T lymphocytes positively stained for Fas protein from JSLE patients were significantly increased compared to healthy controls, patients with JRA and patients with JDM. Percentages of B lymphocytes positive for Fas from JSLE patients were higher than healthy controls and JRA patients. In addition, Fas expression on T cells from patients with JRA was increased compared to JDM patients. Otherwise, Fas expression on T and B cells from JRA and JDM patients were similar to healthy controls. MFI of Bcl-2 positive T lymphocytes from JSLE patients were significantly increased compared to healthy controls and JRA patients. MFI of Bcl-2 protein on B lymphocytes from JSLE patients was similar to healthy controls and patients with JRA and JDM. Bcl-2 expression did not differ between JRA and JDM patients and healthy controls. In conclusion, increased expression of Fas and Bcl-2 proteins observed in circulating T and B lymphocytes from patients with JSLE, but not from patients with JRA and JDM, suggests that abnormalities of apoptosis may be related to the pathogenesis of JSLE and probably are not a result of chronic inflammation.

  19. Lipid profiles of adipose and muscle tissues in mouse models of juvenile onset of obesity without high fat diet induction: a Fourier transform infrared (FT-IR) spectroscopic study.

    Science.gov (United States)

    Sen, Ilke; Bozkurt, Ozlem; Aras, Ebru; Heise, Sebastian; Brockmann, Gudrun Anni; Severcan, Feride

    2015-06-01

    The current study aims to determine lipid profiles in terms of the content and structure of skeletal muscle and adipose tissues to better understand the characteristics of juvenile-onset spontaneous obesity without high fat diet induction. For the purposes of this study, muscle (longissimus, quadriceps) and adipose (inguinal, gonadal) tissues of 10-week-old male DBA/2J and Berlin fat mouse inbred (BFMI) lines (BFMI856, BFMI860, BFMI861) fed with a standard breeding diet were used. Biomolecular structure and composition was determined using attenuated total reflection Fourier transform (ATR FT-IR) spectroscopy, and muscle triglyceride content was further quantified using high-performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The results revealed a loss of unsaturation in BFMI860 and BFMI861 lines in both muscles and inguinal adipose tissue, together with a decrease in the hydrocarbon chain length of lipids, especially in the BFMI860 line in muscles, suggesting an increased lipid peroxidation. There was an increase in saturated lipid and triglyceride content in all tissues of BFMI lines, more profoundly in longissimus muscle, where the increased triglyceride content was quantitatively confirmed by HPLC-ELSD. Moreover, an increase in the metabolic turnover of carbohydrates in muscles of the BFMI860 line was observed. The results demonstrated that subcutaneous (inguinal) fat also displayed considerable obesity-induced alterations. Taken together, the results revealed differences in lipid structure and content of BFMI lines, which may originate from different insulin sensitivity levels of the lines, making them promising animal models for spontaneous obesity. The results will contribute to the understanding of the generation of insulin resistance in obesity without high fat diet induction.

  20. Efficacy of Amitraz plus Metaflumizone for the treatment of canine demodicosis associated with Malassezia pachydermatis

    Directory of Open Access Journals (Sweden)

    Cafarchia Claudia

    2009-03-01

    Full Text Available Abstract This case reports the efficacy of metaflumizone plus amitraz spot-on formulation (ProMeris Duo®; Fort Dodge against generalized demodectic mange. A two year-old male dog presented at clinical examination with poor general condition, diffused alopecia, crusted lesions, pruritus, skin scales and pustules. Demodex mites, Malassezia pachydermatis yeasts and bacteria were diagnosed. The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites. The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days post treatment (p.t. respectively. Nymphs and larvae could not be detected from +28 day p.t. while eggs were no longer present +42 day p.t. The dog was negative for both bacteria and M. pachydermatis at 14 days p.t., coinciding with improved general clinical conditions, recovering skin lesions and no further signs of pruritus. These results show that metaflumizone plus amitraz associated with the antibiotic therapy is highly effective for treating generalized demodectic mange and could also be effective toward controlling M. pachydermatis opportunistic infections.

  1. Presence of antibodies to cyclic citrullinated peptides in juvenile-onset systemic lupus erythematosus%儿童系统性红斑狼疮抗环瓜氨酸肽抗体检测及其临床意义

    Institute of Scientific and Technical Information of China (English)

    刘海英; 刘云锋; 关启鸿; 钟艳玲; 皮蕾; 张白杜; 郭彩娇; 曾华松

    2010-01-01

    Objective To determine the prevalence of antibodies to cyclic citrullinated peptides (antiCCP) in patients with juvenile-onset systemic lupus erythematosus (JSLE) and its potential clinical significance. Methods Anti-CCP was measured in sera from patients with JSLE (n=47), juvenile idiopathic arthritis (JIA, n=54) and the sera from age-matched healthy children (n=40) using the third generation of anti-CCP ELISA commercial kit. The association of anti-CCP with other laboratory parameters and clinical features, especially arthritic symptoms in JSLE was also analyzed. T-test, Mann-Whitney U test, Chi-square and Fisher's exact test were used for statistical analysis. Results Out of the 47 JSLE patients, 6 (13%) were anti-CCP positive, which was significantly higher than that of the healthy controls( 13% vs 0, P<0.05 ), but not different from that of the JIA group (26%, P=0.098). RF was more prevalent in JSLE patients with anti-CCP than patients without (83% vs 15%, P<0.01 ), but there was no difference in other laboratory parameters and the clinical features ineluding the occurrence of arthritis (67% vs 51%, P>0.05). As one of the initial symptoms, arthritis was observed in 25 of 47 JSLE patients and no one had developed deforming arthropathy.There was no statistical difference in anti-CCP positivity between JSLE patients with and without articular involvement ( 16% vs 9%, P>0.05 ). Anti-CCP was not detected in any of the 3 patients with JSLE who had experienced joint pain and limited activity during 3 years follow-up. Conclusion Anti-CCP could be detected in patients with JSLE. It is noteworthy when differentiate from juvenile idiopathic arthritis, but the presence of anti-CCP does not relate with the occurrence of arthritis at presentation and persistence of arthritis in JSLE.%目的 检测儿童系统性红斑狼疮(JSLE)患者血清抗环瓜氨酸肽(CCP)抗体水平,了解抗CCP抗体在该病中的阳性检出率以及探讨其与

  2. A child with ictal vocalizations and generalized epilepsy.

    Science.gov (United States)

    Kurian, Mary; Heritier Barras, Anne-Chantal; Korff, Christian M

    2015-03-01

    Ictal vocalizations in the form of both articulate speech and non-speech vocalizations have been described in focal epilepsies, with seizures originating mainly from the frontal and temporal lobe, however, this phenomenon has not been described in generalized epilepsies. We report the case of an adolescent boy with juvenile-onset generalized epilepsy who presented with ictal "ovine vocalizations" (resembling the bleating of sheep). The ictal EEG revealed a clear correlate of vocalizations with time-locked generalized spikes and polyspike discharges. The 3T cerebral MRI ruled out any focal lesion. The boy is currently seizure-free under valproic acid, after twelve months of follow-up. We conclude that ictal non-speech vocalizations may be observed not only in focal or structural epilepsies, but also in generalized epilepsies; the exact underlying mechanism of this phenomenon needs to be further delineated. [Published with video sequence].

  3. Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1 diabetes

    NARCIS (Netherlands)

    Kharagjitsingh, A.V.; de Ridder, M.A.J.; Alizadeh, B.Z.; Veeze, H.J.; Bruining, G.J.; Roep, B.O.; Koeleman, Bobby P.C.

    2012-01-01

    Objective: We previously showed that accelerated growth predisposing to development of childhood-onset type 1 diabetes (T1D) is restricted to the first year after birth. We assessed whether this phenomenon of increased early growth is associated with variants of two genes, insulin-like growth factor

  4. Hepatitis C virus antibodies in high risk juvenile onset systemic lupus erythematosus.

    Science.gov (United States)

    Aikawa, Nádia E; Nascimento, Ana P; Hayata, André L S; Bonfá, Eloisa; Goldenstein-Schainberg, Cláudia

    2016-01-01

    To evaluate the prevalence of hepatitis C virus (HCV) infection in high risk juvenile systemic lupus erythematosus (JSLE). Forty low income JSLE patients (6M:34F; mean age 19±4.4 yrs; mean disease duration 6±3.2 yrs) were studied. Twenty healthy children and adolescents matched for social economical level were included as controls. Anti-HCV tests were performed using a third generation microparticle enzyme immunoassay. Inclusion criterion was low social economical level. The frequencies of anti-HCV antibody were low and comparable between JSLE and control group (2.5% vs. 0, p=1.0). JSLE patients had significantly more risk factors for HCV infection compared to the control group, including immunosuppressive treatment (90% vs. 0, p<0.0001), hospitalization (50% vs. 12.5%, p=0.0006) and invasive procedures (47.5% vs. 12.5%, p=0.001). The observed low frequency of anti-HCV antibodies in high risk JSLE suggests that this virus does not seem to have a relevant role in the pathogenesis of this disease. Copyright © 2016 Elsevier Editora Ltda. All rights reserved.

  5. Juvenile-onset spinal muscular atrophy caused by compound heterozygosity for mutations in the HEXA gene.

    Science.gov (United States)

    Navon, R; Khosravi, R; Melki, J; Drucker, L; Fontaine, B; Turpin, J C; N'Guyen, B; Fardeau, M; Rondot, P; Baumann, N

    1997-05-01

    Progressive proximal muscle weakness is present both in spinal muscular atrophy (SMA) type III (Kugelberg-Welander disease) and in GM2 gangliosidosis, diseases that segregate in an autosomal recessive fashion. The SMN gene for SMA and the HEXA gene for GM2 gangliosidosis were investigated in a woman with progressive proximal muscle weakness, long believed to be SMA type III (Kugelberg-Welander type). She and her family underwent biochemical studies for GM2 gangliosidosis. Analysis of SMN excluded SMA. Biochemical studies on GM2 gangliosidosis showed deficiency in hexosaminidase A activity and increased GM2 ganglioside accumulation in the patient's fibroblasts. The HEXA gene was first analyzed for the Gly269-->Ser mutation characteristic for adult GM2 gangliosidosis. Since the patient was carrying the adult mutation heterozygously, all 14 exons and adjacent intron sequences were analyzed. A novel mutation in exon 1 resulting in an A-to-T change in the initiation codon (ATG to TTG) was identified. The adult patient is a compound heterozygote, with each allele containing a different mutation. Although mRNA was transcribed from the novel mutant allele, expression experiments showed no enzyme activity, suggesting that neither the TTG nor an alternative codon serve as an initiation codon in the HEXA gene.

  6. Predictive genetic testing in minors for Myocilin juvenile onset open angle glaucoma.

    Science.gov (United States)

    Souzeau, E; Glading, J; Ridge, B; Wechsler, D; Chehade, M; Dubowsky, A; Burdon, K P; Craig, J E

    2015-12-01

    Myocilin glaucoma is an autosomal dominant disorder leading to irreversible blindness, but early intervention can minimize vision loss and delay disease progression. The purpose of this study was to discuss the benefits of predictive genetic testing in minors for Myocilin mutations associated with childhood onset glaucoma. Three families with Myocilin mutations associated with an age of onset before 18 years and six unaffected at-risk children were identified. Predictive genetic testing was discussed with the parents and offered for at-risk minors. Parents opted for genetic testing in half of the cases. None carried the familial mutation. The age of disease onset in the family, the severity of the condition, and the age of the child are all factors that appear to influence the decision of the parent to test their children. Predictive genetic testing for early onset Myocilin glaucoma can facilitate early detection of disease or discharge from routine ophthalmic examinations.

  7. Metabolic factors in the development of retinopathy of juvenile-onset type I diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Khosla P

    1994-01-01

    Full Text Available Thirty-five patients of insulin-dependent diabetes mellitus (IDDM were investigated for the effect of various metabolic factors on retinopathy. The severity of retinopathy increased with duration and age of onset of IDDM. Degree of glycaemia (fasting blood sugar, FBS was similar in patients with or without retinopathy. All IDDM patients as a group showed severe carbohydrate intolerance with lower basal and post glucose serum immunoreactive insulin (IRI levels and serum C-peptide radioimmunoreactivity (CPR as compared to controls. The insulin secretory response was similar in no retinopathy, mild retinopathy and severe retinopathy groups. Patients with retinopathy had higher incidence of hyperlipidemia but mean serum levels of cholesterol and triglyceride were similar. This study does not suggest a direct relationship between the various metabolic factors studied and retinopathy due to IDDM

  8. Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1 diabetes

    NARCIS (Netherlands)

    Kharagjitsingh, Av; de Ridder, Maj; Alizadeh, Bz; Veeze, Hj; Bruining, Gj; Roep, Bo; Koeleman, Bobby Pc

    2012-01-01

    OBJECTIVE: We previously showed that accelerated growth predisposing to development of childhood-onset type 1 diabetes (T1D) is restricted to the first year after birth. We assessed whether this phenomenon of increased early growth is associated with variants of two genes, insulin-like growth factor

  9. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis

    DEFF Research Database (Denmark)

    Silverberg, Michael J.; Thorsen, Poul; Lindeberg, Henning

    2003-01-01

    risk of disease relative to births without a maternal history of genital warts. In women with genital warts, delivery times of more than 10 hours were associated with a two-fold greater risk of disease. Cesarean delivery was not found to be protective against respiratory papillomatosis, and no other...

  10. Juvenile and juvenile-onset systemic lupus erythematosus patients: Clinical characteristics, disease activity and damage

    Directory of Open Access Journals (Sweden)

    Rasha E. Gheith

    2017-07-01

    Conclusion: The existence of differences in clinical phenotype has been confirmed, between JSLE and JO-SLE especially as regards serositis, nephritis and heamatological affection. The disease damage was comparable which denotes that the maximum organ involvement occurs in childhood with an almost stationary course.

  11. Geographical Clustering of Juvenile Onset Systemic Lupus Erythematosus within the Sultanate of Oman

    Directory of Open Access Journals (Sweden)

    Ibrahim Al-Zakwani

    2013-05-01

    Full Text Available Objective: While SLE is found worldwide, there is diversity in clinical presentation of the disease according to geographical variations. The aim of this study is to describe geographical distributions of childhood onset SLE within Oman to identify geographical clustering and to compare the demographic, clinical, and immunological characteristics of this cluster against the rest of Oman.Methods: We retrospectively reviewed the hospital charts of 104 consecutive children with childhood onset SLE who were seen in pediatric rheumatology centers in the Sultanate of Oman over a 15-year period between 1995 and 2010.Results: Geographical clustering of childhood onset SLE was identified in Sharqiya region, which constituted 41% (n=43 of all cases in Oman. This cohort of patients had characteristic disease features which consisted of significantly more boys affected with SLE compared to the rest of the country (42% versus 15%; p=0.002. These children also tended to be younger (10.3 versus 16.5 years; p=0.001, diagnosed at an earlier age (6.4 versus 9.4 years; p<0.001 with a stronger family history of SLE (58% versus 33%; p=0.010. These children also had increased incidence of mucocutanous changes (81% versus 62%; p=0.036 and decreased hematological abnormalities (30% versus 51%; p=0.036.Conclusion: We identified geographical clustering of childhood onset SLE to Sharqiya region in Oman which is associated with unique demographical and clinical features. Whether increased prevalence of disease in this region is due to geographical, environmental, ethnic or genetic factors is yet to be determined. However, it is likely to be interplay of known and other unrecognized factors.

  12. Bovine demodicosis: a case report Demodicose bovina: relato de caso

    Directory of Open Access Journals (Sweden)

    L.S. Lemos

    2005-12-01

    Full Text Available Tissues samples collected at necropsy from a 9 year-old Holstein cow were fixed in buffered 10% formalin for histological examination. Macroscopic finding did not reveal typical nodular cutaneous lesions. Vulvar microscopic sections of cutaneous tegument showed mites (Demodex bovis, alone and grouped in hair follicles and sebaceous glands.Amostras de tecidos colhidas à necropsia de uma vaca da raça Holandesa, nove anos de idade, foram fixadas em formol neutro a 10% e enviadas para exames histológicos. A macroscopia não revelou lesões nodulares cutâneas típicas de demodicose. Secções microscópicas de tegumento cutâneo da vulva evidenciaram ácaros (Demodex bovis isolados ou em grupos no interior de folículos pilosos e glândulas sebáceas.

  13. Demodicosis caused by Demodex canis and Demodex cornei in dogs.

    Science.gov (United States)

    Sivajothi, S; Sudhakara Reddy, B; Rayulu, V C

    2015-12-01

    Two mongrel dogs aged between 7 and 9 months in a same house were presented to the clinics with a history of chronic dermatitis associated with pruritus. Clinical examination revealed presence of primary and secondary skin lesions on the face, around the ears, chin, neck, fore limbs and lateral abdomen. Examination of skin scrapings revealed Demodex cornei (majority) and D. canis (minority) in both the dogs. By using hair pluck examination D. canis were detected and by tape impression smears examination large number of adult short-tail Demodex mites were found. D. cornei was identified by based on the morphological characters including short opisthosoma with blind and round terminal end. Mean length of total body, opisthosoma of both types of the mites were differed statistically significant (P  0.05). Dogs were treated with daily oral ivermectin @ 500 μg/kg/day, external application of amitraz along with supportive therapy. After completion of 45 days of therapy dogs were recovered completely without any side effects.

  14. Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions

    DEFF Research Database (Denmark)

    Zhou, J; Hertz, Jens Michael; Tryggvason, K

    1992-01-01

    A single base mutation was identified in the type IV collagen alpha 5 chain gene (COL4A5) of a Danish kindred with Alport syndrome. The 27-year-old male proband developed hematuria in childhood and terminal renal failure at the age of 25 years. He has no hearing loss or ocular lesions. Electron.......9-kb fragments present in control DNA but the presence of a 2.2-kb variant fragment, indicating the loss of an MspI restriction site in the 3' end of the gene. The mother had all three fragments, indicating heterozygosity. PCR amplification of exon 14 (counted from the 3' end) and subsequent denaturing...

  15. Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions

    DEFF Research Database (Denmark)

    Zhou, J; Hertz, Jens Michael; Tryggvason, K

    1992-01-01

    -specific probes confirmed the inheritance of the mutation with the phenotype. The mutation changed the GGC codon for glycine-1143 to GAC for aspartate. Substitution of glycine-1143, located in the collagenous domain of the alpha 5(IV) chain, for any other amino acid can be expected to interfere......A single base mutation was identified in the type IV collagen alpha 5 chain gene (COL4A5) of a Danish kindred with Alport syndrome. The 27-year-old male proband developed hematuria in childhood and terminal renal failure at the age of 25 years. He has no hearing loss or ocular lesions. Electron...... gradient gel electrophoresis analysis suggested a sequence variant in the proband and his mother. This was confirmed by sequencing of the PCR-amplified exon 14 region of the hemizygous proband, which demonstrated the base change G----A abolishing an MspI restriction site. Hybridization analysis with allele...

  16. Macrophage activation syndrome as the initial manifestation of severe juvenile onset systemic lupus erythematosus. Favorable response to cyclophosphamide.

    Science.gov (United States)

    Torres Jiménez, Alfonso; Solís Vallejo, Eunice; Zeferino Cruz, Maritza; Céspedes Cruz, Adriana; Sánchez Jara, Berenice

    2014-01-01

    The macrophage activation syndrome is a rare but potentially fatal complication of patients with autoimmune rheumatic diseases. This is a clinicopathological entity characterized by activation of histiocytes with prominent hemophagocytosis in the bone marrow and other reticuloendothelial systems. In patients with lupus it may mimic an exacerbation of the disease or infection. We report the case of a 7-year-old girl in whom the diagnosis of lupus erythematosus and macrophage activation syndrome was simultaneously made with response to the use of cyclophosphamide.

  17. Different familial association patterns of autoimmune diseases between juvenile-onset systemic lupus erythematosus and juvenile rheumatoid arthritis.

    Science.gov (United States)

    Huang, Chun-Mei; Yang, Yao-Hsu; Chiang, Bor-Luen

    2004-04-01

    The aim of this study was to determine if the prevalence of autoimmune disorders in the relatives of patients with systemic lupus erythematosus (SLE) is greater than that of relatives of patients with juvenile rheumatoid arthritis (JRA). Interviews were used to obtain histories of the following autoimmune disorders among living or deceased first-, second-, and third-degree relatives of 91 SLE and 110 JRA families: ankylosing spondylitis, SLE, rheumatoid arthritis (RA), JRA, multiple sclerosis, juvenile dermatomyositis, Sjögren's syndrome, myasthenia gravis, psoriasis, and thyroid diseases. There were statistically significant differences between the SLE and JRA probands in mean age and gender ratio (19.1 +/- 4.8 vs 14.0 +/- 5.5 years; M (male)/F (female): 17/74 vs 62/48, pJRA families (11.8%), but not statistically significantly so. The mean age (18.0 +/- 5.3 vs 14.0 +/- 4.3 years), mean age at diagnosis (13.4 +/- 4.3 vs 7.9 +/- 3.9 years) and gender ratio (F/M, 16/3 vs 5/8) of the patients with affected relatives between these 2 groups all had statistically significant differences. A higher prevalence of SLE in relatives was found in SLE families than in JRA cases. Furthermore, this study revealed a higher incidence of autoimmune disorders among second- and third-degree relatives of SLE or JRA probands versus first-degree ones, especially sisters (including 1 pair of twins) and the maternal aunt in SLE families. These data demonstrate that the prevalence of autoimmune disorders in the relatives of patients with SLE is greater than those of relatives of patients with JRA. This suggests that clinically different autoimmune phenotypes may share common susceptibility genes, which may act as risk factors for autoimmunity.

  18. General Dentist

    Science.gov (United States)

    ... Some general dentists work in government health services, research programs, higher education, corporations and even the military. ?xml:namespace> What kind of procedures do general dentists provide? ?xml:namespace> Many general dentists are ...

  19. Generalized product

    OpenAIRE

    Greco,Salvatore; Mesiar, Radko; Rindone, Fabio

    2014-01-01

    Aggregation functions on [0,1] with annihilator 0 can be seen as a generalized product on [0,1]. We study the generalized product on the bipolar scale [–1,1], stressing the axiomatic point of view. Based on newly introduced bipolar properties, such as the bipolar increasingness, bipolar unit element, bipolar idempotent element, several kinds of generalized bipolar product are introduced and studied. A special stress is put on bipolar semicopulas, bipolar quasi-copulas and bipolar copulas.

  20. Generalized product

    OpenAIRE

    Greco, Salvatore; Mesiar, Radko; Rindone, Fabio

    2014-01-01

    Aggregation functions on [0,1] with annihilator 0 can be seen as a generalized product on [0,1]. We study the generalized product on the bipolar scale [–1,1], stressing the axiomatic point of view. Based on newly introduced bipolar properties, such as the bipolar increasingness, bipolar unit element, bipolar idempotent element, several kinds of generalized bipolar product are introduced and studied. A special stress is put on bipolar semicopulas, bipolar quasi-copulas and bipolar copulas.

  1. General Conformity

    Science.gov (United States)

    The General Conformity requirements ensure that the actions taken by federal agencies in nonattainment and maintenance areas do not interfere with a state’s plans to meet national standards for air quality.

  2. General Anesthesia

    Science.gov (United States)

    ... unconscious and unable to feel pain during medical procedures. General anesthesia usually uses a combination of intravenous drugs ... 1998-2017 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.

  3. Generalized polygons

    CERN Document Server

    Van Maldeghem, Hendrik

    1998-01-01

    Generalized Polygons is the first book to cover, in a coherent manner, the theory of polygons from scratch. In particular, it fills elementary gaps in the literature and gives an up-to-date account of current research in this area, including most proofs, which are often unified and streamlined in comparison to the versions generally known. Generalized Polygons will be welcomed both by the student seeking an introduction to the subject as well as the researcher who will value the work as a reference. In particular, it will be of great value for specialists working in the field of generalized polygons (which are, incidentally, the rank 2 Tits-buildings) or in fields directly related to Tits-buildings, incidence geometry and finite geometry. The approach taken in the book is of geometric nature, but algebraic results are included and proven (in a geometric way!). A noteworthy feature is that the book unifies and generalizes notions, definitions and results that exist for quadrangles, hexagons, octagons - in the ...

  4. Generalized derivations and general relativity

    CERN Document Server

    Heller, M; Pysiak, L; Sasin, W

    2013-01-01

    We construct differential geometry (connection, curvature, etc.) based on generalized derivations of an algebra A. Such a derivation, introduced by Bresar in 1991, is given by a linear mapping u: A -> A such that there exists a usual derivation d of A satisfying the generalized Leibniz rule u(a b) = u(a) b + a d(b) for all a,b in A. The generalized geometry "is tested" in the case of the algebra of smooth functions on a manifold. We then apply this machinery to study the generalized general relativity. We define the Einstein-Hilbert action and deduce from it Einstein's field equations. We show that for a special class of metrics containing, besides the usual metric components, only one non-zero term, the action reduces to O'Hanlon action that is a Brans-Dicke action with potential and with the parameter \\omega equal to zero. We also show that the generalized Einstein equations (with zero energy-stress tensor) are equivalent to those of the Kaluza-Klein theory satisfying a "modified cylinder condition" and hav...

  5. GENERAL EQUILIBRIUM

    Directory of Open Access Journals (Sweden)

    Monique Florenzano

    2008-09-01

    Full Text Available General equilibrium is a central concept of economic theory. Unlike partial equilibrium analysis which study the equilibrium of a particular market under the clause “ceteris paribus” that revenues and prices on the other markets stay approximately unaffected, the ambition of a general equilibrium model is to analyze the simultaneous equilibrium in all markets of a competitive economy. Definition of the abstract model, some of its basic results and insights are presented. The important issues of uniqueness and local uniqueness of equilibrium are sketched; they are the condition for a predictive power of the theory and its ability to allow for statics comparisons. Finally, we review the main extensions of the general equilibrium model. Besides the natural extensions to infinitely many commodities and to a continuum of agents, some examples show how economic theory can accommodate the main ideas in order to study some contexts which were not thought of by the initial model

  6. General Relativity

    CERN Document Server

    Canuto, V

    2015-01-01

    This is an English translation of the Italian version of an encyclopedia chapter that appeared in the Italian Encyclopedia of the Physical Sciences, edited by Bruno Bertotti (1994). Following requests from colleagues we have decided to make it available to a more general readership. We present the motivation for constructing General Relativity, provide a short discussion of tensor algebra, and follow the set up of Einstein equations. We discuss briefly the initial value problem, the linear approximation and how should non gravitational physics be described in curved spacetime.

  7. General Assembly

    CERN Multimedia

    Staff Association

    2016-01-01

    5th April, 2016 – Ordinary General Assembly of the Staff Association! In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, April 5th 2016 from 11:00 to 12:00 in BE Auditorium, Meyrin (6-2-024). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its financial management, and an opportunity to express one’s opinion, including taking part in the votes. Other points are listed on the agenda, as proposed by the Staff Council. Who can vote? Only “ordinary” members (MPE) of the SA can vote. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give his/her opinion? The Ordinary General Asse...

  8. Generalized Parabolas

    Science.gov (United States)

    Joseph, Dan; Hartman, Gregory; Gibson, Caleb

    2011-01-01

    In this article we explore the consequences of modifying the common definition of a parabola by considering the locus of all points equidistant from a focus and (not necessarily linear) directrix. The resulting derived curves, which we call "generalized parabolas," are often quite beautiful and possess many interesting properties. We show that…

  9. General discussion

    NARCIS (Netherlands)

    Jagers op Akkerhuis, Gerard A.J.M.

    2016-01-01

    The general discussion focuses on some aspects that are of overarching relevance for all the preceding chapters. The fi rst subject that is discussed is the relationship between systems theory and the philosophy of science. After a short summary of the principles of system science and the

  10. Generale preventie

    NARCIS (Netherlands)

    1949-01-01

    In part I of this study a survey has veen given of what Dutch authors have written since 1870, when capital punishment was abolished, on subjects concerning the general preventive effect of punishment. This historical survey ends where, during the years 1940-1945, under the stress of the occupation

  11. [General psychotherapy].

    Science.gov (United States)

    Vymetal, J

    2003-01-01

    Nowadays a theoretical psychotherapeutical thinking develops from the eclectic practice and uses particularly the research of the effective factors of the therapy. Best they can be characterized as differentiate, synthetic, integrative and exceeding other approaches. The development in question goes on with attempts of creating a general model of the psychotherapy that could be a basis for models of special psychotherapies. The aim of such a model is to describe all that is present as important factor for inducing a desirable change of a human in all psychotherapeutical approaches. Among general models we can mention the generic model of D. E. Orlinski and K. I. Howard, Grawe's cube (the author is K. Grawe) and the equation of the psychotherapy.

  12. Generalized polygons

    CERN Document Server

    Maldeghem, Hendrik

    1998-01-01

    This book is intended to be an introduction to the fascinating theory ofgeneralized polygons for both the graduate student and the specialized researcher in the field. It gathers together a lot of basic properties (some of which are usually referred to in research papers as belonging to folklore) and very recent and sometimes deep results. I have chosen a fairly strict geometrical approach, which requires some knowledge of basic projective geometry. Yet, it enables one to prove some typically group-theoretical results such as the determination of the automorphism groups of certain Moufang polygons. As such, some basic group-theoretical knowledge is required of the reader. The notion of a generalized polygon is a relatively recent one. But it is one of the most important concepts in incidence geometry. Generalized polygons are the building bricks of Tits buildings. They are the prototypes and precursors of more general geometries such as partial geometries, partial quadrangles, semi-partial ge­ ometries, near...

  13. General Relativity

    CERN Document Server

    Khriplovich, I. B

    2005-01-01

    This book offers an alternative to other textbooks on the subject, providing a more specific discussion of numerous general relativistic effects for readers who have knowledge of classical mechanics and electrodynamics, including special relativity. Coverage includes gravitational lensing, signal retardation in the gravitational field of the Sun, the Reissner-Nordström solution, selected spin effects, the resonance transformation of an electromagnetic wave into a gravitational one, and the entropy and temperature of black holes. The book includes numerous problems at various levels of difficulty, making it ideal also for independent study by a broad readership of advanced students and researchers. I.B. Khriplovich is Chief Researcher, Budker Institute of Nuclear Physics, Novosibirsk, and Chair of Theoretical Physics at Novosibirsk University. Dr. Khriplovich is a Corresponding Member of the Russian Academy of Sciences. He has been awarded the Dirac Medal ``For the advancement of theoretical physics'' by Univ...

  14. [General anesthesia].

    Science.gov (United States)

    Feiss, P

    2001-04-30

    General anaesthesia is a reversible loss of consciousness induced and maintained with a hypnotic drug given either by venous injection and infusion, or by inhalation. A potent opioid is usually associated to inhibit the transmission of pain and thus to lessen sympathetic and endocrine reactions to nociceptive stimuli. Myorelaxation is used to facilitate tracheal intubation and surgery. Whatever the anaesthetic protocol use, the patient and anaesthesia machine require close monitoring. In addition to vital signs, the depth of anaesthesia may be monitored using automated electroencephalographic analysis and myorelaxation should always be monitored using a nerve stimulator, but pain or analgesia evaluation is only based on clinical signs of sympathetic stimulation. Because anaesthesia-related death and morbidity have decreased considerably, future improvements in outcome should concern perioperative comfort, i.e. prevention of cognitive disturbances, nausea, vomiting and pain.

  15. A Generalization of Generalized Fibonacci and Generalized Pell Numbers

    Science.gov (United States)

    Abd-Elhameed, W. M.; Zeyada, N. A.

    2017-01-01

    This paper is concerned with developing a new class of generalized numbers. The main advantage of this class is that it generalizes the two classes of generalized Fibonacci numbers and generalized Pell numbers. Some new identities involving these generalized numbers are obtained. In addition, the two well-known identities of Sury and Marques which…

  16. Generalized periodic and generalized Boolean rings

    Directory of Open Access Journals (Sweden)

    Howard E. Bell

    2001-01-01

    Full Text Available We prove that a generalized periodic, as well as a generalized Boolean, ring is either commutative or periodic. We also prove that a generalized Boolean ring with central idempotents must be nil or commutative. We further consider conditions which imply the commutativity of a generalized periodic, or a generalized Boolean, ring.

  17. General(es) remisión de V. escuelas general(es).

    OpenAIRE

    2011-01-01

    [ES] Definición del término General(es) remisión de V. escuelas general(es). en el diccionario Dicter. [EN] Definition of the word General(es) remisión de V. escuelas general(es). in the dictionary Dicter.

  18. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population.

    Science.gov (United States)

    Udwadia-Hegde, Anaita; Hajirnis, Omkar

    2017-01-01

    Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.

  19. A Case Report of the Management of Demodicosis in the Golden Hamster

    National Research Council Canada - National Science Library

    長谷川, 貴史

    1995-01-01

    1.6歳, 雄のゴールデンハムスターが背部の脱毛を主訴に来院した. 一般状態はやや低下し, 脱毛部に中程度の痒みを認めた. 皮膚掻爬試験の結果, 毛包虫が確認された. 1%硫化セレンのシャンプーと0.013%アミトラズの局所塗布を用いた併用療法を行ったが, 本症を完治させることはできなかった....

  20. General Nuclear Medicine

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z General Nuclear Medicine Nuclear medicine imaging uses small amounts of ... limitations of General Nuclear Medicine? What is General Nuclear Medicine? Nuclear medicine is a branch of medical ...

  1. General Ultrasound Imaging

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures ... limitations of General Ultrasound Imaging? What is General Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  2. Calfornia General Plans Rural

    Data.gov (United States)

    California Department of Resources — We undertook creating the first ever seamless statewide General Plan map for California. All county general plans and many city general plans were integrated into 1...

  3. Calfornia General Plans

    Data.gov (United States)

    California Department of Resources — We undertook creating the first ever seamless statewide General Plan map for California. All county general plans and many city general plans were integrated into 1...

  4. Calfornia General Plans

    Data.gov (United States)

    California Department of Resources — We undertook creating the first ever seamless statewide General Plan map for California. All county general plans and many city general plans were integrated into 1...

  5. Generalized Probability Functions

    Directory of Open Access Journals (Sweden)

    Alexandre Souto Martinez

    2009-01-01

    Full Text Available From the integration of nonsymmetrical hyperboles, a one-parameter generalization of the logarithmic function is obtained. Inverting this function, one obtains the generalized exponential function. Motivated by the mathematical curiosity, we show that these generalized functions are suitable to generalize some probability density functions (pdfs. A very reliable rank distribution can be conveniently described by the generalized exponential function. Finally, we turn the attention to the generalization of one- and two-tail stretched exponential functions. We obtain, as particular cases, the generalized error function, the Zipf-Mandelbrot pdf, the generalized Gaussian and Laplace pdf. Their cumulative functions and moments were also obtained analytically.

  6. GENERALIZED WEAK FUNCTIONS

    Institute of Scientific and Technical Information of China (English)

    丁夏畦; 罗佩珠

    2004-01-01

    In this paper the authors introduce some new ideas on generalized numbers and generalized weak functions. They prove that the product of any two weak functions is a generalized weak function. So in particular they solve the problem of the multiplication of two generalized functions.

  7. Generalized holomorphic structures

    Science.gov (United States)

    Wang, Yicao

    2014-12-01

    We define the notion of generalized holomorphic principal bundles and establish that their associated vector bundles of holomorphic representations are generalized holomorphic vector bundles defined by M. Gualtieri. Motivated by our definition, several examples of generalized holomorphic structures are constructed. A reduction theorem of generalized holomorphic structures is also included.

  8. How general is general information construct?

    Directory of Open Access Journals (Sweden)

    Predrag Zarevski

    2005-04-01

    Full Text Available There is a small number of constructs in the field of differential psychology that have raised so much debate between psychologists and professionals in related disciplines as is the case of general (verbal information construct. It seemed reasonable to test the validity of this construct measured with general information test in comparison with other measures of knowledge (cultural knowledge, vocabulary, knowledge of the most recent events, foreign language knowledge, and a standard verbal type g test. A sample of 376 candidates for state services was tested in a selection situation. Three analyses were conducted to determine the position of general information test in the space of other verbal competency measures. The first analysis questioned latent structure of the space of four tests having the same format and asking about the knowledge of international terms, general culture, knowledge of most recent events, and general information. The second analysis included the g-factor intelligence test so to see how the above described structure changes when this new test is introduced. The third analysis introduced an English language test. In all of the three component analyses only one eigenvalue was larger than 1 and it explained between 52 and 64% of variance. In all analyses general information test had the highest projection on the only significant latent dimension of these cognitive spaces. In other words, it can be concluded that the construct of general information is in the center of this hyperconus. That is why we consider measurement of general information knowledge, as well as the construct itself, to be an important question in psychological diagnostics. Thus, it is important to go further with the investigation of this construct because it does not seem that it is named general information by accident.

  9. Introduction to general and generalized linear models

    CERN Document Server

    Madsen, Henrik

    2010-01-01

    IntroductionExamples of types of data Motivating examples A first view on the modelsThe Likelihood PrincipleIntroduction Point estimation theory The likelihood function The score function The information matrix Alternative parameterizations of the likelihood The maximum likelihood estimate (MLE) Distribution of the ML estimator Generalized loss-function and deviance Quadratic approximation of the log-likelihood Likelihood ratio tests Successive testing in hypothesis chains Dealing with nuisance parameters General Linear ModelsIntroduction The multivariate normal distribution General linear mod

  10. Generalized adjoint systems

    CERN Document Server

    Serakos, Demetrios

    2015-01-01

    This book defines and develops the generalized adjoint of an input-output system. It is the result of a theoretical development and examination of the generalized adjoint concept and the conditions under which systems analysis using adjoints is valid. Results developed in this book are useful aids for the analysis and modeling of physical systems, including the development of guidance and control algorithms and in developing simulations. The generalized adjoint system is defined and is patterned similarly to adjoints of bounded linear transformations. Next the elementary properties of the generalized adjoint system are derived. For a space of input-output systems, a generalized adjoint map from this space of systems to the space of generalized adjoints is defined. Then properties of the generalized adjoint map are derived. Afterward the author demonstrates that the inverse of an input-output system may be represented in terms of the generalized adjoint. The use of generalized adjoints to determine bounds for ...

  11. On generalized extending modules

    Institute of Scientific and Technical Information of China (English)

    ZENG Qing-yi

    2007-01-01

    A module M is called generalized extending if for any submodule N of M, there is a direct summand K of M such that N≤K and K/N is singular. Any extending module and any singular module are generalized extending. Any homomorphic image of a generalized extending module is generalized extending. Any direct sum of a singular (uniform) module and a semi-simple module is generalized extending. A ring R is a right Co-H-ring ifand only ifall right R modules are generalized extending modules.

  12. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... are the limitations of General Ultrasound Imaging? What is General Ultrasound Imaging? Ultrasound is safe and painless, ... through the blood vessels. top of page How is the procedure performed? For most ultrasound exams, you ...

  13. General IC Symptoms

    Science.gov (United States)

    ... IC Symptoms of IC General IC Symptoms General IC Symptoms Symptoms of interstitial cystitis (IC) differ from ... news and events. Please leave this field empty Interstitial Cystitis Association 7918 Jones Branch Drive, Suite 300 McLean, ...

  14. Delphi General Ledger -

    Data.gov (United States)

    Department of Transportation — Delphi general ledger contains the following data elements, but is not limited to the United States Standard General Ledger (USSGL) chart of accounts, stores actual,...

  15. Generalized convexity, generalized monotonicity recent results

    CERN Document Server

    Martinez-Legaz, Juan-Enrique; Volle, Michel

    1998-01-01

    A function is convex if its epigraph is convex. This geometrical structure has very strong implications in terms of continuity and differentiability. Separation theorems lead to optimality conditions and duality for convex problems. A function is quasiconvex if its lower level sets are convex. Here again, the geo­ metrical structure of the level sets implies some continuity and differentiability properties for quasiconvex functions. Optimality conditions and duality can be derived for optimization problems involving such functions as well. Over a period of about fifty years, quasiconvex and other generalized convex functions have been considered in a variety of fields including economies, man­ agement science, engineering, probability and applied sciences in accordance with the need of particular applications. During the last twenty-five years, an increase of research activities in this field has been witnessed. More recently generalized monotonicity of maps has been studied. It relates to generalized conve...

  16. Forces in General Relativity

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Many textbooks dealing with general relativity do not demonstrate the derivation of forces in enough detail. The analyses presented herein demonstrate straightforward methods for computing forces by way of general relativity. Covariant divergence of the stress-energy-momentum tensor is used to derive a general expression of the force experienced…

  17. Forces in General Relativity

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Many textbooks dealing with general relativity do not demonstrate the derivation of forces in enough detail. The analyses presented herein demonstrate straightforward methods for computing forces by way of general relativity. Covariant divergence of the stress-energy-momentum tensor is used to derive a general expression of the force experienced…

  18. Generalized Poisson sigma models

    CERN Document Server

    Batalin, I; Batalin, Igor; Marnelius, Robert

    2001-01-01

    A general master action in terms of superfields is given which generates generalized Poisson sigma models by means of a natural ghost number prescription. The simplest representation is the sigma model considered by Cattaneo and Felder. For Dirac brackets considerably more general models are generated.

  19. Generalized Fourier transforms classes

    DEFF Research Database (Denmark)

    Berntsen, Svend; Møller, Steen

    2002-01-01

    The Fourier class of integral transforms with kernels $B(\\omega r)$ has by definition inverse transforms with kernel $B(-\\omega r)$. The space of such transforms is explicitly constructed. A slightly more general class of generalized Fourier transforms are introduced. From the general theory...

  20. Generalization Rough Set Theory

    Institute of Scientific and Technical Information of China (English)

    XIAO Di; ZHANG Jun-feng; HU Shou-song

    2008-01-01

    In order to avoid the discretization in the classical rough set theory, a generlization rough set theory is proposed.At first, the degree of general importance of an attribute and attribute subsets are presented.Then, depending on the degree of general importance of attribute, the space distance can be measured with weighted method.At last, a generalization rough set theory based on the general near neighborhood relation is proposed.The proposed theory partitions the universe into the tolerant modules, and forms lower approximation and upper approximation of the set under general near neighborhood relationship, which avoids the discretization in Pawlak's rough set theory.

  1. Unsupervised Learning and Generalization

    DEFF Research Database (Denmark)

    Hansen, Lars Kai; Larsen, Jan

    1996-01-01

    The concept of generalization is defined for a general class of unsupervised learning machines. The generalization error is a straightforward extension of the corresponding concept for supervised learning, and may be estimated empirically using a test set or by statistical means-in close analogy ...... with supervised learning. The empirical and analytical estimates are compared for principal component analysis and for K-means clustering based density estimation...

  2. General surgery career resource.

    Science.gov (United States)

    Parsee, Ana M; Ross, Sharona B; Gantt, Nancy L; Kichler, Kandace; Hollands, Celeste

    2013-11-01

    General surgery residency training can lead to a rewarding career in general surgery and serve as the foundation for careers in several surgical subspecialties. It offers broad-based training with exposure to the cognitive and technical aspects of several surgical specialties and prepares graduating residents for a wide range of career paths. This career development resource discusses the training aspects of general surgery. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Generalized Group Signature Scheme

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The concept of generalized group signature scheme will bepresent. Based on the generalized secret sharing scheme proposed by Lin and Ha rn, a non-interactive approach is designed for realizing such generalized group signature scheme. Using the new scheme, the authorized subsets of the group in w hich the group member can cooperate to produce the valid signature for any messa ge can be randomly specified

  4. Generalized quasi variational inequalities

    Energy Technology Data Exchange (ETDEWEB)

    Noor, M.A. [King Saud Univ., Riyadh (Saudi Arabia)

    1996-12-31

    In this paper, we establish the equivalence between the generalized quasi variational inequalities and the generalized implicit Wiener-Hopf equations using essentially the projection technique. This equivalence is used to suggest and analyze a number of new iterative algorithms for solving generalized quasi variational inequalities and the related complementarity problems. The convergence criteria is also considered. The results proved in this paper represent a significant improvement and refinement of the previously known results.

  5. Academy of General Dentistry

    Science.gov (United States)

    ... continuing education. BECOME A FELLOW OR MASTER Continuing Education Access the latest CE opportunities, including live and on-demand webinars, specifically designed for the general dentist. BROWSE ...

  6. Geoinformation Generalization by Aggregation

    Directory of Open Access Journals (Sweden)

    Tomislav Jogun

    2016-12-01

    Full Text Available Geoinformation generalization can be divided into model generalization and cartographic generalization. Model generalization is the supervised reduction of data in a model, while cartographic generalization is the reduction of the complexity of map content adapted to the map scale, and/or use by various generalization operators (procedures. The topic of this paper is the aggregation of geoinformation. Generally, aggregation is the joining of nearby, congenial objects, when the distance between them is smaller than the minimum sizes. Most researchers in geoinformation generalization have focused on line features. However, the appearance of web-maps with point features and choropleth maps has led to the development of concepts and algorithms for the generalization of point and polygonal features. This paper considers some previous theoretical premises and actual examples of aggregation for point, line and polygonal features. The algorithms for aggregation implemented in commercial and free GIS software were tested. In the conclusion, unresolved challenges that occur in dynamic cartographic visualizations and cases of unusual geometrical features are highlighted.

  7. Generalized Fibonacci zone plates

    CERN Document Server

    Ke, Jie; Zhu, Jianqiang

    2015-01-01

    We propose a family of zone plates which are produced by the generalized Fibonacci sequences and their axial focusing properties are analyzed in detail. Compared with traditional Fresnel zone plates, the generalized Fibonacci zone plates present two axial foci with equal intensity. Besides, we propose an approach to adjust the axial locations of the two foci by means of different optical path difference, and further give the deterministic ratio of the two focal distances which attributes to their own generalized Fibonacci sequences. The generalized Fibonacci zone plates may allow for new applications in micro and nanophotonics.

  8. On Generalized Bell Polynomials

    Directory of Open Access Journals (Sweden)

    Roberto B. Corcino

    2011-01-01

    Full Text Available It is shown that the sequence of the generalized Bell polynomials Sn(x is convex under some restrictions of the parameters involved. A kind of recurrence relation for Sn(x is established, and some numbers related to the generalized Bell numbers and their properties are investigated.

  9. Generalizing Experimental Findings

    Science.gov (United States)

    2015-06-01

    new method using propensity score stratified sampling. Journal of Research on Educational Effectiveness 7 114–135. 11 ...Generalizing Experimental Findings Judea Pearl University of California, Los Angeles Computer Science Department Los Angeles, CA, 90095-1596, USA...Selection Bias The classical problem of generalizing experimental findings from the trial sample to the population as a whole, also known as the problem

  10. Assessment of General Education

    Science.gov (United States)

    Furman, Tanya

    2013-01-01

    The assessment of general education is often approached through broad surveys or standardized instruments that fail to capture the learning goals most faculty members desire for this portion of the curriculum. The challenge in remedying this situation lies, first, in defining general education in meaningful ways that can be both articulated and…

  11. Communication: General Semantics Perspectives.

    Science.gov (United States)

    Thayer, Lee, Ed.

    This book contains the edited papers from the eleventh International Conference on General Semantics, titled "A Search for Relevance." The conference questioned, as a central theme, the relevance of general semantics in a world of wars and human misery. Reacting to a fundamental Korzybski-ian principle that man's view of reality is distorted by…

  12. Reliability Generalization: "Lapsus Linguae"

    Science.gov (United States)

    Smith, Julie M.

    2011-01-01

    This study examines the proposed Reliability Generalization (RG) method for studying reliability. RG employs the application of meta-analytic techniques similar to those used in validity generalization studies to examine reliability coefficients. This study explains why RG does not provide a proper research method for the study of reliability,…

  13. Certificateless Generalized Signcryption

    Science.gov (United States)

    Ji, Huifang; Han, Wenbao; Zhao, Long

    Generalized Signcryption is a fresh cryptographic primitive that not only can obtain encryption and signature in a single operation, but also provide encryption or signature model alone when needed. This paper proposed a formal definition of certificateless generalized signcryption(CLGSC), then provide the security model of CLGSC. A concrete CLGSC scheme is also given in this paper.

  14. On generalized topological spaces

    OpenAIRE

    Piȩkosz, Artur

    2009-01-01

    In this paper a systematic study of the category GTS of generalized topological spaces (in the sense of H. Delfs and M. Knebusch) and their strictly continuous mappings begins. Some completeness and cocompleteness results are achieved. Generalized topological spaces help to reconstruct the important elements of the theory of locally definable and weakly definable spaces in the wide context of weakly topological structures.

  15. Generalizing: The descriptive struggle

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, Ph.D.; Hon Ph.D.

    2006-11-01

    Full Text Available The literature is not kind to the use of descriptive generalizations. Authors struggle and struggle to find and rationalize a way to use them and then fail in spite of trying a myriad of work-arounds. And then we have Lincoln and Guba’s famous statement: “The only generalization is: there is no generalization” in referring to qualitative research. (op cit, p. 110 They are referring to routine QDA yielding extensive descriptions, but which tacitly include conceptual generalizations without any real thought of knowledge about them. In this chapter I wish to explore this struggle for the purpose of explaining that the various contra arguments to using descriptive generalizations DO NOT apply to the ease of using conceptual generalizations yielded in SGT and especially FGT. I will not argue for the use of descriptive generalization. I agree with Lincoln and Guba with respect to QDA, “the only generalization is: there is no generalization.” It is up to the QDA methodologists, of whom there are many; to continue the struggle and I wish them well.

  16. Generalized connectivity of graphs

    CERN Document Server

    Li, Xueliang

    2016-01-01

    Noteworthy results, proof techniques, open problems and conjectures in generalized (edge-) connectivity are discussed in this book. Both theoretical and practical analyses for generalized (edge-) connectivity of graphs are provided. Topics covered in this book include: generalized (edge-) connectivity of graph classes, algorithms, computational complexity, sharp bounds, Nordhaus-Gaddum-type results, maximum generalized local connectivity, extremal problems, random graphs, multigraphs, relations with the Steiner tree packing problem and generalizations of connectivity. This book enables graduate students to understand and master a segment of graph theory and combinatorial optimization. Researchers in graph theory, combinatorics, combinatorial optimization, probability, computer science, discrete algorithms, complexity analysis, network design, and the information transferring models will find this book useful in their studies.

  17. Generalized Galilean Genesis

    CERN Document Server

    Nishi, Sakine

    2015-01-01

    The galilean genesis scenario is an alternative to inflation in which the universe starts expanding from Minkowski in the asymptotic past by violating the null energy condition stably. Several concrete models of galilean genesis have been constructed so far within the context of galileon-type scalar-field theories. We give a generic, unified description of the galilean genesis scenario in terms of the Horndeski theory, i.e., the most general scalar-tensor theory with second-order field equations. In doing so we generalize the previous models to have a new parameter (denoted by {\\alpha}) which results in controlling the evolution of the Hubble rate. The background dynamics is investigated to show that the generalized galilean genesis solution is an attractor, similarly to the original model. We also study the nature of primordial perturbations in the generalized galilean genesis scenario. In all the models described by our generalized genesis Lagrangian, amplification of tensor perturbations does not occur as ...

  18. Generalized Kahler geometry

    CERN Document Server

    Gualtieri, Marco

    2010-01-01

    Generalized Kahler geometry is the natural analogue of Kahler geometry, in the context of generalized complex geometry. Just as we may require a complex structure to be compatible with a Riemannian metric in a way which gives rise to a symplectic form, we may require a generalized complex structure to be compatible with a metric so that it defines a second generalized complex structure. We explore the fundamental aspects of this geometry, including its equivalence with the bi-Hermitian geometry on the target of a 2-dimensional sigma model with (2,2) supersymmetry, as well as the relation to holomorphic Dirac geometry and the resulting derived deformation theory. We also explore the analogy between pre-quantum line bundles and gerbes in the context of generalized Kahler geometry.

  19. General relativity and cosmology

    CERN Document Server

    Bucher, Martin

    2015-01-01

    This year marks the hundredth anniversary of Einstein's 1915 landmark paper "Die Feldgleichungen der Gravitation" in which the field equations of general relativity were correctly formulated for the first time, thus rendering general relativity a complete theory. Over the subsequent hundred years physicists and astronomers have struggled with uncovering the consequences and applications of these equations. This contribution, which was written as an introduction to six chapters dealing with the connection between general relativity and cosmology that will appear in the two-volume book "One Hundred Years of General Relativity: From Genesis and Empirical Foundations to Gravitational Waves, Cosmology and Quantum Gravity," endeavors to provide a historical overview of the connection between general relativity and cosmology, two areas whose development has been closely intertwined.

  20. Guidelines for the Child with Diabetes in the Classroom.

    Science.gov (United States)

    Maryland State Dept. of Health and Mental Hygiene, Baltimore.

    These guidelines are intended to aid Maryland teachers in managing the child with diabetes in the classroom. After a brief description of juvenile onset diabetes, information is provided on signs and symptoms of diabetes, general management, recognition and treatment of hypoglycemia, treatment, other recommendations, recognition and treatment of…

  1. Inductive, Analogical, and Communicative Generalization

    Directory of Open Access Journals (Sweden)

    Adri Smaling

    2003-03-01

    Full Text Available Three forms of inductive generalization - statistical generalization, variation-based generalization and theory-carried generalization - are insufficient concerning case-to-case generalization, which is a form of analogical generalization. The quality of case-to-case generalization needs to be reinforced by setting up explicit analogical argumentation. To evaluate analogical argumentation six criteria are discussed. Good analogical reasoning is an indispensable support to forms of communicative generalization - receptive and responsive (participative generalization — as well as exemplary generalization.

  2. Context-dependent generalization.

    Science.gov (United States)

    Taylor, Jordan A; Ivry, Richard B

    2013-01-01

    The pattern of generalization following motor learning can provide a probe on the neural mechanisms underlying learning. For example, the breadth of generalization to untrained regions of space after visuomotor adaptation to targets in a restricted region of space has been attributed to the directional tuning properties of neurons in the motor system. Building on this idea, the effect of different types of perturbations on generalization (e.g., rotation vs. visual translation) have been attributed to the selection of differentially tuned populations. Overlooked in this discussion is consideration of how the context of the training environment may constrain generalization. Here, we explore the role of context by having participants learn a visuomotor rotation or a translational shift in two different contexts, one in which the array of targets were presented in a circular arrangement and the other in which they were presented in a rectilinear arrangement. The perturbation and environments were either consistent (e.g., rotation with circular arrangement) or inconsistent (e.g., rotation with rectilinear arrangement). The pattern of generalization across the workspace was much more dependent on the context of the environment than on the perturbation, with broad generalization for the rectilinear arrangement for both types of perturbations. Moreover, the generalization pattern for this context was evident, even when the perturbation was introduced in a gradual manner, precluding the use of an explicit strategy. We describe how current models of generalization might be modified to incorporate these results, building on the idea that context provides a strong bias for how the motor system infers the nature of the visuomotor perturbation and, in turn, how this information influences the pattern of generalization.

  3. Context-dependent Generalization

    Directory of Open Access Journals (Sweden)

    Jordan A Taylor

    2013-05-01

    Full Text Available The pattern of generalization following motor learning can provide a probe on the neural mechanisms underlying learning. For example, the breadth of generalization to untrained regions of space after visuomotor adaptation to targets in a restricted region of space has been attributed to the directional tuning properties of neurons in the motor system. Building on this idea, the effect of different types of perturbations on generalization (e.g., rotation versus visual translation have been attributed to the selection of differentially tuned populations. Overlooked in this discussion is consideration of how the context of the training environment may constrain generalization. Here, we explore the role of context by having participants learn a visuomotor rotation or a translational shift in two different contexts, one in which the array of targets were presented in a circular arrangement and the other in which they were presented in a rectilinear arrangement. The perturbation and environments were either consistent (e.g., rotation with circular arrangement or inconsistent (e.g., rotation with rectilinear arrangement. The pattern of generalization across the workspace was much more dependent on the context of the environment than on the perturbation, with broad generalization for the rectilinear arrangement for both types of perturbations. Moreover, the generalization pattern for this context was evident, even when the perturbation was introduced in a gradual manner, precluding the use of an explicit strategy. We describe how current models of generalization might be modified to incorporate these results, building on the idea that context provides a strong bias for how the motor system infers the nature of the visuomotor perturbation and, in turn, how this information influences the pattern of generalization.

  4. General game playing

    CERN Document Server

    Genesereth, Michael

    2014-01-01

    General game players are computer systems able to play strategy games based solely on formal game descriptions supplied at ""runtime"" (n other words, they don't know the rules until the game starts). Unlike specialized game players, such as Deep Blue, general game players cannot rely on algorithms designed in advance for specific games; they must discover such algorithms themselves. General game playing expertise depends on intelligence on the part of the game player and not just intelligence of the programmer of the game player.GGP is an interesting application in its own right. It is intell

  5. General artificial neuron

    Science.gov (United States)

    Degeratu, Vasile; Schiopu, Paul; Degeratu, Stefania

    2007-05-01

    In this paper the authors present a model of artificial neuron named the general artificial neuron. Depending on application this neuron can change self number of inputs, the type of inputs (from excitatory in inhibitory or vice versa), the synaptic weights, the threshold, the type of intensifying functions. It is achieved into optoelectronic technology. Also, into optoelectronic technology a model of general McCulloch-Pitts neuron is showed. The advantages of these neurons are very high because we have to solve different applications with the same neural network, achieved from these neurons, named general neural network.

  6. Generalizing: The descriptive struggle

    OpenAIRE

    Barney G Glaser, Ph.D.; Hon Ph.D.

    2006-01-01

    The literature is not kind to the use of descriptive generalizations. Authors struggle and struggle to find and rationalize a way to use them and then fail in spite of trying a myriad of work-arounds. And then we have Lincoln and Guba’s famous statement: “The only generalization is: there is no generalization” in referring to qualitative research. (op cit, p. 110) They are referring to routine QDA yielding extensive descriptions, but which tacitly include conceptual generalizations without an...

  7. Generalized interaction in multigravity

    CERN Document Server

    Duplij, Steven

    2013-01-01

    A general approach to description of multigravity models in D-dimensional space-time is presented. Different possibilities of generalization of the invariant volume are given. Then a most general form of the interaction potential is constructed, which for bigravity coincides with the Pauli-Fierz model. A thorough analysis of the model along the 3+1 expansion formalism is done. It is shown that the absence of ghosts the considered bigravity model is equivalent in the weak field limit to the massive gravity (the Pauli-Fierz model). Thus, on the concrete example it is shown, that the interaction between metrics leads to nonvanishing mass of graviton.

  8. Generalized Fibonacci photon sieves.

    Science.gov (United States)

    Ke, Jie; Zhang, Junyong

    2015-08-20

    We successfully extend the standard Fibonacci zone plates with two on-axis foci to the generalized Fibonacci photon sieves (GFiPS) with multiple on-axis foci. We also propose the direct and inverse design methods based on the characteristic roots of the recursion relation of the generalized Fibonacci sequences. By switching the transparent and opaque zones, according to the generalized Fibonacci sequences, we not only realize adjustable multifocal distances but also fulfill the adjustable compression ratio of focal spots in different directions.

  9. The General PBW Property

    Institute of Scientific and Technical Information of China (English)

    Huishi Li

    2007-01-01

    For ungraded quotients of an arbitrary Z-graded ring, we define the general PBW property, that covers the classical PBW property and the N-type PBW property studied via the N-Koszulity by several authors (see [2-4]). In view of the noncommutative Gr(o)bner basis theory, we conclude that every ungraded quotient of a path algebra (or a free algebra) has the general PBW property. We remark that an earlier result of Golod [5]concerning Gr(o)bner bases can be used to give a homological characterization of the general PBW property in terms of Shafarevich complex. Examples of applicatipn are given.

  10. Allowable Generalized Quantum Gates

    Institute of Scientific and Technical Information of China (English)

    LONG Gui-Lu; LIU Yang; WANG Chuan

    2009-01-01

    In this paper, we give the most general duality gates, or generalized quantum gates in duality quantum computers. Here we show by explicit construction that a n-bit duality quantum computer with d slits can be simulated perfectly with an ordinary quantum computer with n qubits and one auxiliary qudit. Using this model, we give the most general form of duality gates which is of the form Σ(d-1)(i=0)piUi, and the Pi's are complex numbers with module less or equal to I and constrained by |Σipi|≤1.

  11. Modern general topology

    CERN Document Server

    Nagata, J-I

    1985-01-01

    This classic work has been fundamentally revised to take account of recent developments in general topology. The first three chapters remain unchanged except for numerous minor corrections and additional exercises, but chapters IV-VII and the new chapter VIII cover the rapid changes that have occurred since 1968 when the first edition appeared.The reader will find many new topics in chapters IV-VIII, e.g. theory of Wallmann-Shanin's compactification, realcompact space, various generalizations of paracompactness, generalized metric spaces, Dugundji type extension theory, linearly ordered topolo

  12. Generalized estimating equations

    CERN Document Server

    Hardin, James W

    2002-01-01

    Although powerful and flexible, the method of generalized linear models (GLM) is limited in its ability to accurately deal with longitudinal and clustered data. Developed specifically to accommodate these data types, the method of Generalized Estimating Equations (GEE) extends the GLM algorithm to accommodate the correlated data encountered in health research, social science, biology, and other related fields.Generalized Estimating Equations provides the first complete treatment of GEE methodology in all of its variations. After introducing the subject and reviewing GLM, the authors examine th

  13. General Motors Goes Metric

    Science.gov (United States)

    Webb, Ted

    1976-01-01

    Describes the program to convert to the metric system all of General Motors Corporation products. Steps include establishing policy regarding employee-owned tools, setting up training plans, and making arrangements with suppliers. (MF)

  14. Generalized Anxiety Disorder

    Science.gov (United States)

    ... Anxiety, anxiety disorders, anxious, behavior therapy, GAD, generalized anxiety disorder, mental health neuroses, mood disorders, psychiatric disorder, psychotherapy Family Health, Men, Seniors, Women January 1996 Copyright © American Academy of Family PhysiciansThis ...

  15. Generalized Higher Gauge Theory

    CERN Document Server

    Ritter, Patricia; Schmidt, Lennart

    2015-01-01

    We study a generalization of higher gauge theory which makes use of generalized geometry and seems to be closely related to double field theory. The local kinematical data of this theory is captured by morphisms of graded manifolds between the canonical exact Courant Lie 2-algebroid $TM\\oplus T^*M$ over some manifold $M$ and a semistrict gauge Lie 2-algebra. We discuss generalized curvatures and their infinitesimal gauge transformations. Finite gauge transformation as well as global kinematical data are then obtained from principal 2-bundles over 2-spaces. As dynamical principle, we consider first the canonical Chern-Simons action for such a gauge theory. We then show that a previously proposed 3-Lie algebra model for the six-dimensional (2,0) theory is very naturally interpreted as a generalized higher gauge theory.

  16. General American: An Ambiguity

    Science.gov (United States)

    Van Riper, William R.

    1973-01-01

    Disputes use of the term General American'' because of the excessive breadth of its scope and its indefiniteness; article is part of Lexicography and Dialect Geography, Festgabe for Hans Kurath''. (DD)

  17. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... General ultrasound procedure View full size with caption Pediatric Content Some imaging tests and treatments have special pediatric considerations. The teddy bear denotes child-specific content. ...

  18. Engineering general intelligence

    CERN Document Server

    Goertzel, Ben; Geisweiller, Nil

    2014-01-01

    The work outlines a novel conceptual and theoretical framework for understanding Artificial General Intelligence and based on this framework outlines a practical roadmap for the development of AGI with capability at the human level and ultimately beyond.

  19. General Quantization Rule

    CERN Document Server

    Maiz, F

    2012-01-01

    A general quantization rule for bound states of the Schrodinger equation is presented. Like fundamental theory of integral, our idea is mainly based on dividing the potential into many pieces, solving the Schr\\"odinger equation, and deriving the general quantization rule. For both exactly and non-exactly solvable systems, the energy levels of all the bound states can be easily calculated from the general quantization rule. Using this new general quantization rule, we re-calculate the energy levels for the one-dimensional system, with an infinite square well, with the harmonic oscillator potential, with the Morse Potential, with the symmetric and asymmetric Rosen-Morse potentials, with the first P\\"oschl-Teller potential, with the Coulomb Potential, with the V-shape Potential, and the ax^4 potential, and for the three dimensions systems, with the harmonic oscillator potential, with the ordinary Coulomb potential, and for the hydrogen atom.

  20. Generalizing the Lorentz transformations

    CERN Document Server

    Chappell, James M; Iannella, Nicolangelo; Hartnett, John G; Iqbal, Azhar; Abbott, Derek

    2016-01-01

    In this paper we develop a framework allowing a natural extension of the Lorentz transformations. To begin, we show that by expanding conventional four-dimensional spacetime to eight-dimensions that a natural generalization is indeed obtained. We then find with these generalized coordinate transformations acting on Maxwell's equations that the electromagnetic field transformations are nevertheless unchanged. We find further, that if we assume the absence of magnetic monopoles, in accordance with Maxwell's theory, our generalized transformations are then restricted to be the conventional ones. While the conventional Lorentz transformations are indeed recovered from our framework, we nevertheless provide a new perspective into why the Lorentz transformations are constrained to be the conventional ones. Also, this generalized framework may assist in explaining several unresolved questions in electromagnetism as well as to be able to describe quasi magnetic monopoles found in spin-ice systems.

  1. Generalized Higgs inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, Kohei [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kobayashi, Tsutomu [Kyoto Univ. (Japan). Hakubi Center; Kyoto Univ. (Japan). Dept. of Physics; Takahashi, Tomo [Saga Univ. (Japan). Dept. of Physics; Yamaguchi, Masahide [Tokyo Institute of Technology (Japan). Dept. of Physics; Yokoyama, Jun' ichi [Tokyo Univ. (JP). Research Center for the Early Universe (RESCEU); Tokyo Univ., Chiba (JP). Inst. for the Physics and Mathematics of the Universe (IPMU)

    2012-03-15

    We study Higgs inflation in the context of generalized G-inflation, i.e., the most general single-field inflation model with second-order field equations. The four variants of Higgs inflation proposed so far in the literature can be accommodated at one time in our framework. We also propose yet another class of Higgs inflation, the running Einstein inflation model, that can naturally arise from the generalized G-inflation framework. As a result, five Higgs inflation models in all should be discussed on an equal footing. Concise formulas for primordial fluctuations in these generalized Higgs inflation models are provided, which will be helpful to determine which model is favored from the future experiments and observations such as the Large Hadron Collider and the Planck satellite.

  2. Annual General Meeting

    CERN Multimedia

    Staff Association

    2014-01-01

      STAFF ASSOCIATION Our next annual general meeting will take place on : Thursday 22 May 2014 at 11:00 AM Building 40-S2-D01 For further information visit our website : https://indico.cern.ch/event/313124/

  3. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures of the inside of the ... of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or sonography , ...

  4. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... Us News Physician Resources Professions Site Index A-Z General Ultrasound Ultrasound imaging uses sound waves to ... type of examination you will have. For some scans your doctor may instruct you not to eat ...

  5. Superstability of Generalized Derivations

    Directory of Open Access Journals (Sweden)

    Ansari-Piri Esmaeil

    2010-01-01

    Full Text Available We investigate the superstability of the functional equation , where and are the mappings on Banach algebra . We have also proved the superstability of generalized derivations associated to the linear functional equation , where .

  6. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... Index A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures of the inside of ... pictures of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or ...

  7. General Relativity and Energy

    Science.gov (United States)

    Jackson, A. T.

    1973-01-01

    Reviews theoretical and experimental fundamentals of Einstein's theory of general relativity. Indicates that recent development of the theory of the continually expanding universe may lead to revision of the space-time continuum of the finite and unbounded universe. (CC)

  8. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... Most ultrasound scanning is noninvasive (no needles or injections). Occasionally, an ultrasound exam may be temporarily uncomfortable, ... the following text box: Comment: E-mail: Area code: Phone no: Thank you! Images × Image Gallery General ...

  9. Expansores tisulares: Conceptos generales

    Directory of Open Access Journals (Sweden)

    Madelein Centeno-Rodríguez

    2000-09-01

    Full Text Available In this article, we present a review of general concepts regarding tissue expansion, history, operative technique, clinical applications, principal complications as well as advantages and disadvantages presented with the use of this alternative in reconstructive surgery.

  10. Quantum Gauge General Relativity

    Institute of Scientific and Technical Information of China (English)

    WU Ning

    2004-01-01

    Based on gauge principle, a new model on quantum gravity is proposed in the frame work of quantum gauge theory of gravity. The model has local gravitational gauge symmetry, and the field equation of the gravitational gauge field is just the famous Einstein's field equation. Because of this reason, this model is called quantum gauge general relativity, which is the consistent unification of quantum theory and general relativity. The model proposed in this paper is a perturbatively renormalizable quantum gravity, which is one of the most important advantage of the quantum gauge general relativity proposed in this paper. Another important advantage of the quantum gauge general relativity is that it can explain both classical tests of gravity and quantum effects of gravitational interactions, such as gravitational phase effects found in COW experiments and gravitational shielding effects found in Podkletnov experiments.

  11. Milestones of general relativity

    Science.gov (United States)

    Pullin, Jorge

    2017-02-01

    We present a summary for non-specialists of the special issue of the journal Classical and Quantum Gravity on ‘Milestones of general relativity’, commemorating the 100th anniversary of the theory.

  12. Science in General Education

    Science.gov (United States)

    Read, Andrew F.

    2013-01-01

    General education must develop in students an appreciation of the power of science, how it works, why it is an effective knowledge generation tool, and what it can deliver. Knowing what science has discovered is desirable but less important.

  13. Engineering general intelligence

    CERN Document Server

    Goertzel, Ben; Geisweiller, Nil

    2014-01-01

    The work outlines a detailed blueprint for the creation of an Artificial General Intelligence system with capability at the human level and ultimately beyond, according to the Cog Prime AGI design and the Open Cog software architecture.

  14. Tuberculosis: General Information

    Science.gov (United States)

    TB Elimination Tuberculosis: General Information What is TB? Tuberculosis (TB) is a disease caused by germs that are spread from person ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination CS227840_A What Does a Positive Test ...

  15. A Generalized Jacobi Algorithm

    DEFF Research Database (Denmark)

    Vissing, S.; Krenk, S.

    An algorithm is developed for the generalized eigenvalue problem (A - λB)φ = O where A and B are real symmetric matrices. The matrices A and B are diagonalized simultaneously by a series of generalized Jacobi transformations and all eigenvalues and eigenvectors are obtained. A criterion expressed...... in terms of the transformation parameters is used to omit transformations leading to very small changes. The algorithm is described in pseudo code for lower triangular matrices A and B and implemented in the programming Language C.......An algorithm is developed for the generalized eigenvalue problem (A - λB)φ = O where A and B are real symmetric matrices. The matrices A and B are diagonalized simultaneously by a series of generalized Jacobi transformations and all eigenvalues and eigenvectors are obtained. A criterion expressed...

  16. Matter in general relativity

    Science.gov (United States)

    Ray, J. R.

    1982-01-01

    Two theories of matter in general relativity, the fluid theory and the kinetic theory, were studied. Results include: (1) a discussion of various methods of completing the fluid equations; (2) a method of constructing charged general relativistic solutions in kinetic theory; and (3) a proof and discussion of the incompatibility of perfect fluid solutions in anisotropic cosmologies. Interpretations of NASA gravitational experiments using the above mentioned results were started. Two papers were prepared for publications based on this work.

  17. Generalized Supersymetric Boundary State

    OpenAIRE

    1999-01-01

    Following our previous paper (hep-th/9909027), we generalize a supersymmetric boundary state so that arbitrary configuration of the gauge field coupled to the boundary of the worldsheet is incorpolated. This generalized boundary state is BRST invariant and satisfy the non-linear boundary conditions with non-constant gauge field strength. This boundary state contains divergence which is identical with the loop divergence in a superstring sigma model. Hence vanishing of the beta function in the...

  18. Generalized Partial Volume

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2011-01-01

    Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV). Their theoret......Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV...

  19. General Factors in Graphs.

    Science.gov (United States)

    1986-07-01

    conjectured that the general factor problem can be solved in polynomial time when, in each Bi, all the gaps (if any) have length one. We prove this conjecture...exactly bi edges incident with node i, for each i. This problem is well-solved. A polynomial algorithm is known (Edmonds and Johnson (1970)) as well as a...powerful theorem to characterize the existence of solutions ( Tutte (1952)). The following generalization of the factor problem was studied by Lovtsz

  20. -Metric Space: A Generalization

    Directory of Open Access Journals (Sweden)

    Farshid Khojasteh

    2013-01-01

    Full Text Available We introduce the notion of -metric as a generalization of a metric by replacing the triangle inequality with a more generalized inequality. We investigate the topology of the spaces induced by a -metric and present some essential properties of it. Further, we give characterization of well-known fixed point theorems, such as the Banach and Caristi types in the context of such spaces.

  1. [Generalized periarthritis calcarea (generalized hydroxyapatite disease)].

    Science.gov (United States)

    Müller, W; Bahous, I

    1979-09-01

    The condition of generalized periarthritis calcarea (hydroxyapatite deposition disease) is characterised by multiple periarticular calcification which can be localised around practically any joint and also in proximity to the spine. This calcification consists of hydroxyapatite crystals which are responsible for the episodes of acute, subacute or chronic periarticular or articular inflammation so typical of the condition. Because of this one can classify periarthritis calcarea along with gout and chondrocalcinosis in the group of crystal deposition diseases. The actual cause of the calcification remains unknown but it is probable that, along with hereditary factors, disturbances in metabolism play an important role. The diagnosis of generalised periarthritis is made from the characteristic X-ray picture in conjunction with the clinical findings and, on occasion, the demonstration of hydroxyapatite crystals in the affected tissues. In the differential diagnosis gout, chondrocalcinosis, various inflammatory rheumatic conditions and septic arthritis must be excluded and various calcification processes, particularly interstitial calcinosis and lipocal cinogranulomatosis, must also be considered. Since the etiology of the calcification remains unknown to specific treatment is available. Symptomatic treatment with colchicine is mostly inadequate which is why one often has recourse to the use of non-steroid anti-inflammatory drugs and corticosteroids.

  2. Lectures on general relativity

    CERN Document Server

    Papapetrou, Achille

    1974-01-01

    This book is an elaboration of lecture notes for the graduate course on General Rela­ tivity given by the author at Boston University in the spring semester of 1972. It is an introduction to the subject only, as the time available for the course was limited. The author of an introduction to General Relativity is faced from the beginning with the difficult task of choosing which material to include. A general criterion as­ sisting in this choice is provided by the didactic character of the book: Those chapters have to be included in priority, which will be most useful to the reader in enabling him to understand the methods used in General Relativity, the results obtained so far and possibly the problems still to be solved. This criterion is not sufficient to ensure a unique choice. General Relativity has developed to such a degree, that it is impossible to include in an introductory textbook of a reasonable length even a very condensed treatment of all important problems which have been discussed unt...

  3. Generalized galilean genesis

    Energy Technology Data Exchange (ETDEWEB)

    Nishi, Sakine; Kobayashi, Tsutomu [Department of Physics, Rikkyo University, Toshima, Tokyo 175-8501 (Japan)

    2015-03-31

    The galilean genesis scenario is an alternative to inflation in which the universe starts expanding from Minkowski in the asymptotic past by violating the null energy condition stably. Several concrete models of galilean genesis have been constructed so far within the context of galileon-type scalar-field theories. We give a generic, unified description of the galilean genesis scenario in terms of the Horndeski theory, i.e., the most general scalar-tensor theory with second-order field equations. In doing so we generalize the previous models to have a new parameter (denoted by α) which results in controlling the evolution of the Hubble rate. The background dynamics is investigated to show that the generalized galilean genesis solution is an attractor, similarly to the original model. We also study the nature of primordial perturbations in the generalized galilean genesis scenario. In all the models described by our generalized genesis Lagrangian, amplification of tensor perturbations does not occur as opposed to what happens in quasi-de Sitter inflation. We show that the spectral index of curvature perturbations is determined solely from the parameter α and does not depend on the other details of the model. In contrast to the original model, a nearly scale-invariant spectrum of curvature perturbations is obtained for a specific choice of α.

  4. Generalized uncertainty principles

    CERN Document Server

    Machluf, Ronny

    2008-01-01

    The phenomenon in the essence of classical uncertainty principles is well known since the thirties of the last century. We introduce a new phenomenon which is in the essence of a new notion that we introduce: "Generalized Uncertainty Principles". We show the relation between classical uncertainty principles and generalized uncertainty principles. We generalized "Landau-Pollak-Slepian" uncertainty principle. Our generalization relates the following two quantities and two scaling parameters: 1) The weighted time spreading $\\int_{-\\infty}^\\infty |f(x)|^2w_1(x)dx$, ($w_1(x)$ is a non-negative function). 2) The weighted frequency spreading $\\int_{-\\infty}^\\infty |\\hat{f}(\\omega)|^2w_2(\\omega)d\\omega$. 3) The time weight scale $a$, ${w_1}_a(x)=w_1(xa^{-1})$ and 4) The frequency weight scale $b$, ${w_2}_b(\\omega)=w_2(\\omega b^{-1})$. "Generalized Uncertainty Principle" is an inequality that summarizes the constraints on the relations between the two spreading quantities and two scaling parameters. For any two reason...

  5. Generalized classifier neural network.

    Science.gov (United States)

    Ozyildirim, Buse Melis; Avci, Mutlu

    2013-03-01

    In this work a new radial basis function based classification neural network named as generalized classifier neural network, is proposed. The proposed generalized classifier neural network has five layers, unlike other radial basis function based neural networks such as generalized regression neural network and probabilistic neural network. They are input, pattern, summation, normalization and output layers. In addition to topological difference, the proposed neural network has gradient descent based optimization of smoothing parameter approach and diverge effect term added calculation improvements. Diverge effect term is an improvement on summation layer calculation to supply additional separation ability and flexibility. Performance of generalized classifier neural network is compared with that of the probabilistic neural network, multilayer perceptron algorithm and radial basis function neural network on 9 different data sets and with that of generalized regression neural network on 3 different data sets include only two classes in MATLAB environment. Better classification performance up to %89 is observed. Improved classification performances proved the effectivity of the proposed neural network.

  6. General Relativity Today

    Science.gov (United States)

    Blandford, Roger D.

    2016-01-01

    A hundred years after its birth, general relativity has become a highly successful theory in the sese that it has passed many experimental and observational tests and finds widespread application to diverse set of cosmic phenomena. It remains an accurate research field as more tests are deployed, epitomized by the exciting prospect of detecting gravitational radiation directly. General realtivity is the essential foundation of modern cosmology and underlies our detailed description of the black holes and neutron stars that are ultimately responsible for the most powerful and dramatic cosmic sources. The interface with physics on both the largest and the smallest scales continues to be very fertile. In this talk I will attempt to highlight some key steps along the way to general relativity today.

  7. Generalized Gaussian Error Calculus

    CERN Document Server

    Grabe, Michael

    2010-01-01

    For the first time in 200 years Generalized Gaussian Error Calculus addresses a rigorous, complete and self-consistent revision of the Gaussian error calculus. Since experimentalists realized that measurements in general are burdened by unknown systematic errors, the classical, widespread used evaluation procedures scrutinizing the consequences of random errors alone turned out to be obsolete. As a matter of course, the error calculus to-be, treating random and unknown systematic errors side by side, should ensure the consistency and traceability of physical units, physical constants and physical quantities at large. The generalized Gaussian error calculus considers unknown systematic errors to spawn biased estimators. Beyond, random errors are asked to conform to the idea of what the author calls well-defined measuring conditions. The approach features the properties of a building kit: any overall uncertainty turns out to be the sum of a contribution due to random errors, to be taken from a confidence inter...

  8. Generalized Phase Contrast

    CERN Document Server

    Glückstad, Jesper

    2009-01-01

    Generalized Phase Contrast elevates the phase contrast technique not only to improve phase imaging but also to cross over and interface with diverse and seemingly disparate fields of contemporary optics and photonics. This book presents a comprehensive introduction to the Generalized Phase Contrast (GPC) method including an overview of the range of current and potential applications of GPC in wavefront sensing and phase imaging, structured laser illumination and image projection, optical trapping and manipulation, and optical encryption and decryption. The GPC method goes further than the restrictive assumptions of conventional Zernike phase contrast analysis and achieves an expanded range of validity beyond weak phase perturbations. The generalized analysis yields design criteria for tuning experimental parameters to achieve optimal performance in terms of accuracy, fidelity and light efficiency. Optimization can address practical issues, such as finding an optimal spatial filter for the chosen application, ...

  9. Stable generalized complex structures

    CERN Document Server

    Cavalcanti, Gil R

    2015-01-01

    A stable generalized complex structure is one that is generically symplectic but degenerates along a real codimension two submanifold, where it defines a generalized Calabi-Yau structure. We introduce a Lie algebroid which allows us to view such structures as symplectic forms. This allows us to construct new examples of stable structures, and also to define period maps for their deformations in which the background three-form flux is either fixed or not, proving the unobstructedness of both deformation problems. We then use the same tools to establish local normal forms for the degeneracy locus and for Lagrangian branes. Applying our normal forms to the four-dimensional case, we prove that any compact stable generalized complex 4-manifold has a symplectic completion, in the sense that it can be modified near its degeneracy locus to produce a compact symplectic 4-manifold.

  10. Generalized phase contrast:

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin

    Generalized Phase Contrast elevates the phase contrast technique not only to improve phase imaging but also to cross over and interface with diverse and seemingly disparate fields of contemporary optics and photonics. This book presents a comprehensive introduction to the Generalized Phase Contrast...... (GPC) method including an overview of the range of current and potential applications of GPC in wavefront sensing and phase imaging, structured laser illumination and image projection, optical trapping and manipulation, and optical encryption and decryption. The GPC method goes further than...... the restrictive assumptions of conventional Zernike phase contrast analysis and achieves an expanded range of validity beyond weak phase perturbations. The generalized analysis yields design criteria for tuning experimental parameters to achieve optimal performance in terms of accuracy, fidelity and light...

  11. Generalized Multidimensional Association Rules

    Institute of Scientific and Technical Information of China (English)

    周傲英; 周水庚; 金文; 田增平

    2000-01-01

    The problem of association rule mining has gained considerable prominence in the data mining community for its use as an important tool of knowl-edge discovery from large-scale databases. And there has been a spurt of research activities around this problem. Traditional association rule mining is limited to intra-transaction. Only recently the concept of N-dimensional inter-transaction as-sociation rule (NDITAR) was proposed by H.J. Lu. This paper modifies and extends Lu's definition of NDITAR based on the analysis of its limitations, and the general-ized multidimensional association rule (GMDAR) is subsequently introduced, which is more general, flexible and reasonable than NDITAR.

  12. Generalized BPS magnetic monopoles

    CERN Document Server

    Casana, R; da Hora, E

    2012-01-01

    We show the existence of Bogomol'nyi-Prasad-Sommerfield (BPS) magnetic monopoles in a generalized Yang-Mills-Higgs model which is controlled by two positive functions. This effective model, in principle, would describe the dynamics of the nonabelian fields in a chromoelectric media. We check the consistency of our generalized construction by analyzing an explicit case ruled by a real parameter. We also use the well-known spherically symmetric Ansatz to attain the corresponding self-dual equations describing the topological solutions. The overall conclusion is that the new solutions behave around the canonical one, with smaller or greater characteristic length.

  13. General resonance mediation

    Energy Technology Data Exchange (ETDEWEB)

    McGarrie, Moritz

    2012-07-15

    We extend the framework of general gauge mediation to cases where the mediating fields have a nontrivial spectral function, as might arise from strong dynamics. We demonstrate through examples that this setup describes a broad class of possible models of gauge mediated supersymmetry breaking. A main emphasis is to give general formulas for cross sections for {sigma}(visible {yields} hidden) in these resonance models. We will also give formulas for soft masses, A-terms and demonstrate the framework with a holographic setup.

  14. Generalized Erdos Numbers

    CERN Document Server

    Morrison, Greg

    2010-01-01

    We propose a simple real-valued generalization of the well known integer-valued Erdos number as a topological, non-metric measure of the `closeness' felt between two nodes in an undirected, weighted graph. These real-valued Erdos numbers are asymmetric and are able to distinguish between network topologies that standard distance metrics view as identical. We use this measure to study some simple analytically tractable networks, and show the utility of our measure to devise a ratings scheme based on the generalized Erdos number that we deploy on the data from the NetFlix prize, and find a significant improvement in our ratings prediction over a baseline.

  15. Lectures in general algebra

    CERN Document Server

    Kurosh, A G; Stark, M; Ulam, S

    1965-01-01

    Lectures in General Algebra is a translation from the Russian and is based on lectures on specialized courses in general algebra at Moscow University. The book starts with the basics of algebra. The text briefly describes the theory of sets, binary relations, equivalence relations, partial ordering, minimum condition, and theorems equivalent to the axiom of choice. The text gives the definition of binary algebraic operation and the concepts of groups, groupoids, and semigroups. The book examines the parallelism between the theory of groups and the theory of rings; such examinations show the

  16. Mechanics of Generalized Continua

    CERN Document Server

    Maugin, Gerard A

    2010-01-01

    In their 1909 publication "Theorie des corps deformables", Eugene and Francois Cosserat made a historic contribution to materials science by establishing the fundamental principles of the mechanics of generalized continua. The chapters collected in this volume showcase the many areas of continuum mechanics that grew out of the foundational work of the Cosserat brothers. The included contributions provide a detailed survey of the most recent theoretical developments in the field of generalized continuum mechanics. The diverse topics covered include: the properties of Cosserat media, m

  17. The generalized master fields

    Science.gov (United States)

    Cébron, Guillaume; Dahlqvist, Antoine; Gabriel, Franck

    2017-09-01

    The master field is the large N limit of the Yang-Mills measure on the Euclidean plane. It can be viewed as a non-commutative process indexed by loops on the plane. We construct and study generalized master fields, called free planar Markovian holonomy fields which are versions of the master field where the law of a simple loop can be as more general as it is possible. We prove that those free planar Markovian holonomy fields can be seen as well as the large N limit of some Markovian holonomy fields on the plane with unitary structure group.

  18. Topics in general topology

    CERN Document Server

    Morita, K

    1989-01-01

    Being an advanced account of certain aspects of general topology, the primary purpose of this volume is to provide the reader with an overview of recent developments.The papers cover basic fields such as metrization and extension of maps, as well as newly-developed fields like categorical topology and topological dynamics. Each chapter may be read independently of the others, with a few exceptions. It is assumed that the reader has some knowledge of set theory, algebra, analysis and basic general topology.

  19. Generalized Deterministic Traffic Rules

    CERN Document Server

    Fuks, H; Fuks, Henryk; Boccara, Nino

    1997-01-01

    We study a family of deterministic models for highway traffic flow which generalize cellular automaton rule 184. This family is parametrized by the speed limit $m$ and another parameter $k$ that represents a ``degree of aggressiveness'' in driving, strictly related to the distance between two consecutive cars. We compare two driving strategies with identical maximum throughput: ``conservative'' driving with high speed limit and ``aggressive'' driving with low speed limit. Those two strategies are evaluated in terms of accident probability. We also discuss fundamental diagrams of generalized traffic rules and examine limitations of maximum achievable throughput. Possible modifications of the model are considered.

  20. General Motors sidestream separator

    Energy Technology Data Exchange (ETDEWEB)

    Tessier, R.J.

    1981-01-01

    On February 15, 1980, the United States Environmental Protection Agency, acting pursuant to Paragraph 113(D) (4) of the Clean Air Act, issued to General Motors an innovative technology order covering fifteen coal-fired spreader-stoker boilers located at six General Motors plants in Ohio. The purpose and effect of this order was to permit General Motors time to develop a new, innovative technique for controlling particulate emissions from the specified boilers before compliance with the federally approved Ohio particulate control regulation was required. This new technology was christened, The Sidestream Separator, by General Motors. It provides a highly cost effective means of reducing particulate emissions below levels currently obtainable with conventionally used high efficiency mechanical collectors. These improvements could prove to be of substantial benefit to many industrial facilities with spreader-stoker coal-fired boilers that cannot be brought into compliance with applicble air pollution regulations except by application of far more expensive and unwieldly electrostatic precipitators (ESP's) or fabric filters (baghouses).

  1. GENERAL PRINCIPLES OF LAW

    Directory of Open Access Journals (Sweden)

    Elena ANGHEL

    2016-05-01

    Full Text Available According to Professor Djuvara “law can be a science, and legal knowledge can also become science when, referring to a number as large as possible of acts of those covered by law, sorts and connects them by their essential characters upon legal concepts or principles which are universally valid, just like the laws of nature”. The general principles of law take a privileged place in the positive legal order and represent the foundation of any legal construction. The essence of the legal principles resides in their generality. In respect of the term “general”, Franck Moderne raised the question on the degree of generality used in order to define a principle as being general – at the level of an institution, of a branch of the law or at the level of the entire legal order. The purpose of this study is to find out the characteristics of law principles. In our opinion, four characteristics can be mentioned.

  2. Square of General Relativity

    CERN Document Server

    Galtsov, D V

    1996-01-01

    We consider dilaton--axion gravity interacting with $p\\;\\, U(1)$ vectors ($p=6$ corresponding to $N=4$ supergravity) in four--dimensional spacetime admitting a non--null Killing vector field. It is argued that this theory exibits features of a ``square'' of vacuum General Relativity. In the three--dimensional formulation it is equivalent to a gravity coupled $SO(2,2+p)/(SO(2)\\times SO(2+p))$. Kähler coordinates are introduced on the target manifold generalising Ernst potentials of General Relativity. The corresponding Kähler potential is found to be equal to the logarithm of the product of the four--dimensional metric component $g_{00}$ in the Einstein frame and the dilaton factor, independently on presence of vector fields. The complex axidilaton field, while it undergoes holomorphic/antiholomorphic transformations under general target space isometries. The ``square'' property is also manifest in the two--dimensional reduction of the theory as a matrix generalization of the Kramer--Neugebauer map.

  3. Generalized Nuclear Data

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-15

    This software is code related to reading/writing/manipulating nuclear data in the Generalized Nuclear Data (GND) format, a new format for sharing nuclear data among institutions. In addition to the software and its documentation, notes and documentation from the WPEC Subgroup 43 will be included. WPEC Subgroup 43 is an international committee charged with creating the API for the GND format.

  4. General forecasting correcting formula

    OpenAIRE

    Harin, Alexander

    2009-01-01

    A general forecasting correcting formula, as a framework for long-use and standardized forecasts, is created. The formula provides new forecasting resources and new possibilities for expansion of forecasting including economic forecasting into the areas of municipal needs, middle-size and small-size business and, even, to individual forecasting.

  5. General Υ-transformations

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole Eiler; Rosinski, Jan; Thorbjørnsen, Steen

    In this paper we introduce a general class of transformations of (all or most of) the class ML(Rd), of d-dimensional Lévy measures on Rd, into itself. We refer to transformations of this type as Υ transformations (or Upsilon transformations). Closely associated to these are mappings of the set ID...

  6. Superstability of Generalized Derivations

    Directory of Open Access Journals (Sweden)

    Esmaeil Ansari-Piri

    2010-01-01

    Full Text Available We investigate the superstability of the functional equation f(xy=xf(y+g(xy, where f and g are the mappings on Banach algebra A. We have also proved the superstability of generalized derivations associated to the linear functional equation f(γx+βy=γf(x+βf(y, where γ,β∈ℂ.

  7. Generalized Pickands constants

    NARCIS (Netherlands)

    Debicki, K.G.

    2001-01-01

    Pickands constants play an important role in the exact asymptotic of extreme values for Gaussian stochastic processes. By the {it generalized Pickands constant ${cal H_{eta$ we mean the limit begin{eqnarray* {cal H_{eta= lim_{T to inftyfrac{ {cal H_{eta(T){T, end{eqnarray* where ${cal H_{eta(T)= Exp

  8. Interrogation: General vs. Local.

    Science.gov (United States)

    Johnson, Jeannette

    This paper proposes a set of hypotheses on the nature of interrogration as a possible language universal. Examples and phrase structure rules and diagrams are given. Examining Tamazight and English, genetically unrelated languages with almost no contact, the author distinguishes two types of interrogation: (1) general, querying acceptability to…

  9. General forecasting correcting formula

    OpenAIRE

    2009-01-01

    A general forecasting correcting formula, as a framework for long-use and standardized forecasts, is created. The formula provides new forecasting resources and new possibilities for expansion of forecasting including economic forecasting into the areas of municipal needs, middle-size and small-size business and, even, to individual forecasting.

  10. A generalized evidence distance

    Institute of Scientific and Technical Information of China (English)

    Hongming Mo; Xi Lu; Yong Deng

    2016-01-01

    How to efficiently measure the distance between two basic probability assignments (BPAs) is an open issue. In this paper, a new method to measure the distance between two BPAs is proposed, based on two existing measures of evidence distance. The new proposed method is comprehen-sive and generalized. Numerical examples are used to ilus-trate the effectiveness of the proposed method.

  11. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... Español More Info Images/Videos About Us News Physician Resources Professions Site Index A-Z General Ultrasound ... procedure requires little to no special preparation. Your doctor will instruct you on how to prepare, including ...

  12. Generalized granuloma annulare

    Directory of Open Access Journals (Sweden)

    Khatri M

    1995-01-01

    Full Text Available A 35-years-old female patient had generalized pruritic papular lesions, distributed like dermatitis herpetiformis for last 4 years. Histopathologic changes were typical of granuloma annulare with negative results of direct immunofluorescence. The patient did not have association of diabetes mellitus or any other systemic disease. She failed to respond to dapsone therapy and 13-cis-retinoic acid.

  13. Anisotropic generalized Procrustes analysis

    NARCIS (Netherlands)

    Bennani Dosse, Mohammed; Kiers, Henk A.L.; Ten Berge, Jos M.F.

    2011-01-01

    Generalized Procrustes analysis is a popular method for matching several configurations by translations, rotations/reflections and scaling constants. It aims at producing a group average from these Euclidean similarity transformations followed by bi-linear approximation of this group average for gra

  14. QECH general hospital strike

    African Journals Online (AJOL)

    Malawi's only medical school and also hosts the Blantyre cam- pus for the ... 1993 when general civil disobedience in form of street demon- strations, riots and strikes ... However their own rights are limited by their responsibility to save life and ...

  15. Impetigo in General Practice

    NARCIS (Netherlands)

    S. Koning (Sander)

    2005-01-01

    textabstractImpetigo is a common skin infection, usually caused by Staphylococcus aureus that mainly occurs in children. Patients with impetigo usually consult their general practitioner, who also treats the vast majority of cases. Impetigo is considered highly infectious, and consequently childr

  16. Generalized Quantization Condition

    Institute of Scientific and Technical Information of China (English)

    LIANG Zheng; CAO Zhuang-Qi; DENG Xiao-Xu; SHEN Qi-Shun

    2005-01-01

    @@ On the basis of analytical transfer matrix theory, we fine a generalized quantization condition. By introducing a new type of modified momentum, our quantization condition has the same form as the Bohr-Sommerfeld formula.Numerical and analytical comparisons show that the present method is exact.

  17. Learning View Generalization Functions

    CERN Document Server

    Breuel, Thomas M

    2007-01-01

    Learning object models from views in 3D visual object recognition is usually formulated either as a function approximation problem of a function describing the view-manifold of an object, or as that of learning a class-conditional density. This paper describes an alternative framework for learning in visual object recognition, that of learning the view-generalization function. Using the view-generalization function, an observer can perform Bayes-optimal 3D object recognition given one or more 2D training views directly, without the need for a separate model acquisition step. The paper shows that view generalization functions can be computationally practical by restating two widely-used methods, the eigenspace and linear combination of views approaches, in a view generalization framework. The paper relates the approach to recent methods for object recognition based on non-uniform blurring. The paper presents results both on simulated 3D ``paperclip'' objects and real-world images from the COIL-100 database sho...

  18. Generalized uncertainty relations

    Science.gov (United States)

    Herdegen, Andrzej; Ziobro, Piotr

    2017-04-01

    The standard uncertainty relations (UR) in quantum mechanics are typically used for unbounded operators (like the canonical pair). This implies the need for the control of the domain problems. On the other hand, the use of (possibly bounded) functions of basic observables usually leads to more complex and less readily interpretable relations. In addition, UR may turn trivial for certain states if the commutator of observables is not proportional to a positive operator. In this letter we consider a generalization of standard UR resulting from the use of two, instead of one, vector states. The possibility to link these states to each other in various ways adds additional flexibility to UR, which may compensate some of the above-mentioned drawbacks. We discuss applications of the general scheme, leading not only to technical improvements, but also to interesting new insight.

  19. Strains in General Relativity

    CERN Document Server

    Bini, Donato; Geralico, Andrea

    2014-01-01

    The definition of relative accelerations and strains among a set of comoving particles is studied in connection with the geometric properties of the frame adapted to a "fiducial observer." We find that a relativistically complete and correct definition of strains must take into account the transport law of the chosen spatial triad along the observer's congruence. We use special congruences of (accelerated) test particles in some familiar spacetimes to elucidate such a point. The celebrated idea of Szekeres' compass of inertia, arising when studying geodesic deviation among a set of free-falling particles, is here generalized to the case of accelerated particles. In doing so we have naturally contributed to the theory of relativistic gravity gradiometer. Moreover, our analysis was made in an observer-dependent form, a fact that would be very useful when thinking about general relativistic tests on space stations orbiting compact objects like black holes and also in other interesting gravitational situations.

  20. Generalized BPS magnetic monopoles

    Science.gov (United States)

    Casana, R.; Ferreira, M. M., Jr.; da Hora, E.

    2012-10-01

    We show the existence of Bogomol’nyi-Prasad-Sommerfield (BPS) magnetic monopoles in a generalized Yang-Mills-Higgs model which is controlled by two positive functions, g(ϕaϕa) and f(ϕaϕa). This effective model, in principle, would describe the dynamics of the nonabelian fields in a chromoelectric media. We check the consistency of our generalized construction by analyzing an explicit case ruled by a parameter β. We also use the well-known spherically symmetric Ansatz to attain the corresponding self-dual equations describing the topological solutions. The overall conclusion is that the new solutions behave around the canonical one, with smaller or greater characteristic length depending on the values of β.

  1. Generalizing the Minkowski metric

    CERN Document Server

    Chappell, James M; Abbott, Derek

    2015-01-01

    The mathematical framework developed by Minkowski in 1909 successfully explained the new ideas about space and time, developed by Einstein in the special theory of relativity, directly from the geometrical properties of a four-dimensional spacetime continuum. However, while Einstein's theory was firmly based on two physical postulates, the mathematical structure of Minkowski was not so well founded and subsequently there have been many attempts to provide a more fundamental derivation. In this paper we aim to provide such a derivation based on the elementary geometrical properties of three-dimensional space modeled using the algebraic structure of Clifford multivectors. We find that Clifford multivectors produce a generalization of Minkowski's formulation thus placing the results of special relativity in a larger setting. This then leads to a generalization of several results including Noether's theorem.

  2. Beyond generalized Proca theories

    CERN Document Server

    Heisenberg, Lavinia; Tsujikawa, Shinji

    2016-01-01

    We consider higher-order derivative interactions beyond second-order generalized Proca theories that propagate only the three desired polarizations of a massive vector field besides the two tensor polarizations from gravity. These new interactions follow the similar construction criteria to those arising in the extension of scalar-tensor Horndeski theories to Gleyzes-Langlois-Piazza-Vernizzi (GLPV) theories. On the maximally symmetric space-time, we perform the Hessian and Hamiltonian analysis and show the presence of a second-class constraint that removes the would-be ghost associated with the temporal component of the vector field. Furthermore, we study the behavior of linear perturbations on top of the homogeneous and isotropic cosmological background in the presence of a matter perfect fluid and find the same number of propagating degrees of freedom as in generalized Proca theories. Moreover, we obtain the conditions for the avoidance of ghosts and Laplacian instabilities of tensor, vector, and scalar per...

  3. Generalized phase contrast:

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin

    Generalized Phase Contrast elevates the phase contrast technique not only to improve phase imaging but also to cross over and interface with diverse and seemingly disparate fields of contemporary optics and photonics. This book presents a comprehensive introduction to the Generalized Phase Contrast...... (GPC) method including an overview of the range of current and potential applications of GPC in wavefront sensing and phase imaging, structured laser illumination and image projection, optical trapping and manipulation, and optical encryption and decryption. The GPC method goes further than...... efficiency. Optimization can address practical issues, such as finding an optimal spatial filter for the chosen application, and can even enable a Reverse Phase Contrast mode where intensity patterns are converted into a phase modulation....

  4. A Generalized Yield Criterion

    Institute of Scientific and Technical Information of China (English)

    Shijian YUAN; Dazhi XIAO; Zhubin HE

    2004-01-01

    A generalized yield criterion is proposed based on the metal plastic deformation mechanics and the fundamental formula in theory of plasticity. Using the generalized yield criterion, the reason is explained that Mises yield criterion and Tresca yield criterion do not completely match with experimental data. It has been shown that the yield criteria of ductile metals depend not only on the quadratic invariant of the deviatoric stress tensor J2, but also on the cubic invariant of the deviatoric stress tensor J3 and the ratio of the yield stress in pure shear to the yield stress in uniaxial tension k/σs. The reason that Mises yield criterion and Tresca yield criterion are not in good agreement with the experimental data is that the effect of J3 and k/σs is neglected.

  5. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  6. Generalizing unimodular gravity

    CERN Document Server

    Saez-Gomez, Diego

    2016-01-01

    The so-called unimodular version of General Relativity is revisited, which assumes the trace-free part of the equations instead of the usual Einstein equations, what leads naturally to a cosmological constant that may compensate the large value of quantum fluctuations. Here we extend such formalism to some extensions of General Relativity that have drawn a lot of attention over the last years, as $f(R)$ gravity (or its equivalent scalar-tensor picture) and Gauss-Bonnet gravity. The corresponding unimodular version of such theories is constructed. From the classical point of view, the unimodular versions of such extensions are completely equivalent to their originals, but an effective cosmological constant arises naturally, what may provide a richer description of the universe evolution. Moreover, conformal transformations within unimodular gravities lead to some corrections that may affect their solutions. Here we analyze the case of Starobisnky inflation and compared with the original one.

  7. Testing General Relativity

    CERN Document Server

    Tartaglia, Angelo

    2015-01-01

    This lecture will present a review of the past and present tests of the General Relativity theory. The essentials of the theory will be recalled and the measurable effects will be listed and analyzed. The main historical confirmations of General Relativity will be described. Then, the present situation will be reviewed presenting a number of examples. The opportunities given by astrophysical and astrometric observations will be shortly discussed. Coming to terrestrial experiments the attention will be specially focused on ringlasers and a dedicated experiment for the Gran Sasso Laboratories, named by the acronym GINGER, will be presented. Mention will also be made of alternatives to the use of light, such as particle beams and superfluid rings.

  8. Generalized Lotka stability.

    Science.gov (United States)

    Smith, J D H; Zhang, C

    2015-08-01

    The recently developed macroscopic approach to demography describes the age distribution of mothers and the net maternity function for a given human population entirely in terms of five parameters. Tracking of these parameters provides a number of new tools for analyzing populations and predicting their future states. Within the macroscopic approach, the new concept of generalized Lotka stability is presented in this paper, as an extension of a strong version of classic Lotka stability. The two leading parameters of the macroscopic approach, the Malthusian parameter r and the perturbation s, are computed from population data and plotted in two-dimensional parameter space. Generalized Lotka stability is then defined in terms of the movement of the (r,s)-vector over time. It may be observed in a number of human populations at specific periods of their history.

  9. Annual General Asssembly

    CERN Multimedia

    Pension Fund

    2005-01-01

    All members and beneficiaries of the Pension Fund are invited to attend the Annual General Asssembly to be held in the CERN Council Chamber on Thursday 13 October 2005 at 14:30 The Agenda comprises: Opening Remarks (J. Bezemer) Results and presentation of the Annual Report 2004 - Role of asset classes in pension funds (C. Cuénoud). Copies of the 2004 Report are available from departmental secretariats. Package of measures aiming at equilibrating the Fund - Proposals by the Governing Board (J.-P. Matheys). Questions from members and beneficiaries. Persons wishing to ask questions are encouraged to submit them, where possible, in writing in advance, addressed to Mr C. Cuénoud, Administrator of the Fund. Conclusions (J. Bezemer). As usual, participants are invited to drinks after the assembly. NB The minutes of the 2004 General Assembly are available from the Administration of the Fund (tel.(+4122)767 27 42; e-mail Sophia.Revol@cern.ch)

  10. Annual General Asssembly

    CERN Multimedia

    2005-01-01

    All members and beneficiaries of the Pension Fund are invited to attend the Annual General Asssembly to be held in the CERN Council Chamber on Thursday 13 October 2005 at 14:30 The Agenda comprises: Opening Remarks (J. Bezemer) Results and presentation of the Annual Report 2004 - Role of asset classes in pension funds (C. Cuénoud) Copies of the 2004 Report are available from departmental secretariats. Package of measures aiming at equilibrating the Fund - Proposals by the Governing Board (J.-P. Matheys) Questions from members and beneficiaries Persons wishing to ask questions are encouraged to submit them, where possible, in writing in advance, addressed to Mr C. Cuénoud, Administrator of the Fund. Conclusions (J. Bezemer) As usual, participants are invited to drinks after the assembly. NB The minutes of the 2004 General Assembly are available from the Administration of the Fund (tel.(+4122)767 27 42; e-mail Sophia.Revol@cern.ch)

  11. Generalized Hampel Filters

    Science.gov (United States)

    Pearson, Ronald K.; Neuvo, Yrjö; Astola, Jaakko; Gabbouj, Moncef

    2016-12-01

    The standard median filter based on a symmetric moving window has only one tuning parameter: the window width. Despite this limitation, this filter has proven extremely useful and has motivated a number of extensions: weighted median filters, recursive median filters, and various cascade structures. The Hampel filter is a member of the class of decsion filters that replaces the central value in the data window with the median if it lies far enough from the median to be deemed an outlier. This filter depends on both the window width and an additional tuning parameter t, reducing to the median filter when t=0, so it may be regarded as another median filter extension. This paper adopts this view, defining and exploring the class of generalized Hampel filters obtained by applying the median filter extensions listed above: weighted Hampel filters, recursive Hampel filters, and their cascades. An important concept introduced here is that of an implosion sequence, a signal for which generalized Hampel filter performance is independent of the threshold parameter t. These sequences are important because the added flexibility of the generalized Hampel filters offers no practical advantage for implosion sequences. Partial characterization results are presented for these sequences, as are useful relationships between root sequences for generalized Hampel filters and their median-based counterparts. To illustrate the performance of this filter class, two examples are considered: one is simulation-based, providing a basis for quantitative evaluation of signal recovery performance as a function of t, while the other is a sequence of monthly Italian industrial production index values that exhibits glaring outliers.

  12. General -Harmonic Blaschke Bodies

    Indian Academy of Sciences (India)

    Yibin Feng; Weidong Wang

    2014-02-01

    Lutwak introduced the harmonic Blaschke combination and the harmonic Blaschke body of a star body. Further, Feng and Wang introduced the concept of the -harmonic Blaschke body of a star body. In this paper, we define the notion of general -harmonic Blaschke bodies and establish some of its properties. In particular, we obtain the extreme values concerning the volume and the -dual geominimal surface area of this new notion.

  13. Generalized Lindley Distribution

    Directory of Open Access Journals (Sweden)

    H. Zakerzadeh

    2009-06-01

    Full Text Available In this paper, we introduce a three–parameter generalization of the Lindley distribution. This includes as special cases the exponential and gamma distributions. The distribution exhibits decreasing, increasing and bathtub hazard rate depending on its parameters. We study various properties of the new distribution and provide numerical examples to show the flexibility of the model. We also derive a bivariate version of the proposed distribution.

  14. Generalized Conjunction/Disjunction

    DEFF Research Database (Denmark)

    Dujmovic, Jozo; Larsen, Henrik Legind

    2007-01-01

    The generalized conjunction/disjunction function (GCD) is a continuous logic function of two or more variables that integrates conjunctive and disjunctive properties in a single function. It is used as a mathematical model of simultaneity and replaceability of inputs. Special cases of this function......) or disjunction (orness). In this paper, we investigate and compare various versions of GCD and other mathematical models of simultaneity and replaceability that are applicable in the areas of system evaluation, and information retrieval....

  15. Generalized exterior algebras

    OpenAIRE

    Marchuk, Nikolay

    2011-01-01

    Exterior algebras and differential forms are widely used in many fields of modern mathematics and theoretical physics. In this paper we define a notion of $N$-metric exterior algebra, which depends on $N$ matrices of structure constants. The usual exterior algebra (Grassmann algebra) can be considered as 0-metric exterior algebra. Clifford algebra can be considered as 1-metric exterior algebra. $N$-metric exterior algebras for $N\\geq2$ can be considered as generalizations of the Grassmann alg...

  16. On generalized logarithmic electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Kruglov, S.I. [University of Toronto, Department of Chemical and Physical Sciences, Mississauga, ON (Canada)

    2015-02-01

    The generalized logarithmic electrodynamics with two parameters β and γ is considered. The indexes of refraction of light in the external magnetic field are calculated. In the case β = γ we come to results obtained by Gaete and Helayel-Neto (Eur Phys J C 74:2816, 2014). The bound on the values of β, γ was obtained from the Birefringence Magnetique du Vide (BMV) experiment. The symmetrical Belinfante energy-momentum tensor and dilatation current are found. (orig.)

  17. Focal and generalized alopecia.

    Science.gov (United States)

    O'Dair, H A; Foster, A P

    1995-07-01

    Focal or generalized alopecia is defined as hair loss affecting the ventral, lateral, perineal, and dorsal aspects of the trunk of the cat, usually in a symmetric pattern. This may be attributable to failure of hair coat production, excess loss of hair due to self trauma, or excess shedding of whole hairs. Self trauma is the most common cause of hair loss and is associated particularly with flea allergy dermatitis. Other causes of hair loss are reviewed.

  18. General Search Market Equilibrium

    OpenAIRE

    Albrecht, James W.; Axell, Bo

    1982-01-01

    In this paper we extend models of “search market equilibrium” to incorporate general equilibrium considerations. The model we treat is one with a single product market and a single labor market. Imperfectly informed individuals follow optimal strategies in searching for a suitably low price and high wage. For any distribution of price and wage offers across firms these optimal strategies generate product demand and labor supply schedules. Firms then choose prices and wages to maximize expecte...

  19. Generalized fiber Fourier optics.

    Science.gov (United States)

    Cincotti, Gabriella

    2011-06-15

    A twofold generalization of the optical schemes that perform the discrete Fourier transform (DFT) is given: new passive planar architectures are presented where the 2 × 2 3 dB couplers are replaced by M × M hybrids, reducing the number of required connections and phase shifters. Furthermore, the planar implementation of the discrete fractional Fourier transform (DFrFT) is also described, with a waveguide grating router (WGR) configuration and a properly modified slab coupler.

  20. Generalization of Hasimoto's transformation

    CERN Document Server

    Molitor, Mathieu

    2012-01-01

    In this paper, we generalize the famous Hasimoto's transformation by showing that the dynamics of a closed unidimensional vortex filament embedded in a three-dimensional manifold of constant curvature gives rise under Hasimoto's transformation to the non-linear Schrodinger equation. We also give a natural interpretation of the function \\psi introduced by Hasimoto in terms of moving frames associated to a natural complex bundle over the filament.

  1. On Generalized Inverse Transversals

    Institute of Scientific and Technical Information of China (English)

    Rong Hua ZHANG; Shou Feng WANG

    2008-01-01

    Let S be a regular semigroup,S° an inverse subsemigroup of S.S° is called a generalized inverse transversal of S,if V(x) ∩N S°≠φ.In this paper,some properties of this kind of semigroups are discussed.In particular,a construction theorem is obtained which contains some recent results in the literature as its special cases.

  2. GENERALIZED SIMPLE NONCOMMUTATIVE TORI

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The generalized noncommutative torus Tkp of rank n was defined in [4] by the crossed product noncommutative torus Ap of rank n. It is shown in this paper that Tkp is strongly Morita equivalent to Ap, and that Tkp Mp∞ is isomorphic to Ap Mk(C) Mp∞ if and only if the set of prime factors of k is a subset of the set of prime factors of p.

  3. Generalized GCD matrices

    CERN Document Server

    Bege, Antal

    2010-01-01

    Let $f$ be an arithmetical function. The matrix $[f(i,j)]_{n\\times n}$ given by the value of $f$ in greatest common divisor of $(i,j)$, $f\\big((i,j)\\big)$ as its $i,\\; j$ entry is called the greatest common divisor (GCD) matrix. We consider the generalization of this matrix where the elements are in the form $f\\big(i,(i,j)\\big)$.

  4. Tachyons in General Relativity

    OpenAIRE

    Schwartz, Charles

    2011-01-01

    We consider the motion of tachyons (faster-than-light particles) in the framework of General Relativity. An important feature is the large contribution of low energy tachyons to the energy-momentum tensor. We also calculate the gravitational field produced by tachyons in particular geometric arrangements; and it appears that there could be self-cohering bundles of such matter. This leads us to suggest that such theoretical ideas might be relevant to major problems (dark matter and dark energy...

  5. General introduction to glucosinolates

    DEFF Research Database (Denmark)

    Halkier, Barbara Ann

    2016-01-01

    will be presented a general introduction to glucosinolates ranging from the evolution of glucosinolates to the many roles glucosinolates have for humans as well as an overview of the current knowledge on the orchestration of the glucosinolate biosynthetic pathway. The latter includes an introduction to the genes...... to the plasma membrane. Examples of how the knowledge gained from basic research has been translated into applied glucosinolate research through pathway and transport engineering will be presented....

  6. Entrepreneurship within General Aviation

    Science.gov (United States)

    Ullmann, Brian M.

    1995-01-01

    Many modern economic theories place great importance upon entrepreneurship in the economy. Some see the entrepreneur as the individual who bears risk of operating a business in the face of uncertainty about future conditions and who is rewarded through profits and losses. The 20th century economist Joseph Schumpter saw the entrepreneur as the medium by which advancing technology is incorporated into society as businesses seek competitive advantages through more efficient product development processes. Due to the importance that capitalistic systems place upon entrepreneurship, it has become a well studied subject with many texts to discuss how entrepreneurs can succeed in modern society. Many entrepreneuring and business management courses go so far as to discuss the characteristic phases and prominent challenges that fledgling companies face in their efforts to bring a new product into a competitive market. However, even with all of these aids, start-up companies fail at an enormous rate. Indeed, the odds of shepherding a new company through the travails of becoming a well established company (as measured by the ability to reach Initial Public Offering (IPO)) have been estimated to be six in 1,000,000. Each niche industry has characteristic challenges which act as barriers to entry for new products into that industry. Thus, the applicability of broad generalizations is subject to limitations within niche markets. This paper will discuss entrepreneurship as it relates to general aviation. The goals of this paper will be to: introduce general aviation; discuss the details of marrying entrepreneurship with general aviation; and present a sample business plan which would characterize a possible entrepreneurial venture.

  7. Generalized quasiperiodic Rauzy tilings

    Science.gov (United States)

    Vidal, Julien; Mosseri, Rémy

    2001-05-01

    We present a geometrical description of new canonical d-dimensional codimension one quasiperiodic tilings based on generalized Fibonacci sequences. These tilings are made up of rhombi in 2d and rhombohedra in 3d as the usual Penrose and icosahedral tilings. Thanks to a natural indexing of the sites according to their local environment, we easily write down, for any approximant, the sites coordinates, the connectivity matrix and we compute the structure factor.

  8. Generalized Maximum Entropy

    Science.gov (United States)

    Cheeseman, Peter; Stutz, John

    2005-01-01

    A long standing mystery in using Maximum Entropy (MaxEnt) is how to deal with constraints whose values are uncertain. This situation arises when constraint values are estimated from data, because of finite sample sizes. One approach to this problem, advocated by E.T. Jaynes [1], is to ignore this uncertainty, and treat the empirically observed values as exact. We refer to this as the classic MaxEnt approach. Classic MaxEnt gives point probabilities (subject to the given constraints), rather than probability densities. We develop an alternative approach that assumes that the uncertain constraint values are represented by a probability density {e.g: a Gaussian), and this uncertainty yields a MaxEnt posterior probability density. That is, the classic MaxEnt point probabilities are regarded as a multidimensional function of the given constraint values, and uncertainty on these values is transmitted through the MaxEnt function to give uncertainty over the MaXEnt probabilities. We illustrate this approach by explicitly calculating the generalized MaxEnt density for a simple but common case, then show how this can be extended numerically to the general case. This paper expands the generalized MaxEnt concept introduced in a previous paper [3].

  9. Turbulent General Magnetic Reconnection

    CERN Document Server

    Eyink, Gregory L

    2014-01-01

    Plasma flows with an MHD-like turbulent inertial range, such as the solar wind, require a generalization of General Magnetic Reconnection (GMR) theory. We introduce the slip-velocity source vector, which gives the rate of development of slip velocity per unit arc length of field line. The slip source vector is the ratio of the curl of the non ideal electric field in the Generalized Ohm's Law and the magnetic field strength. It diverges at magnetic nulls, unifying GMR with magnetic null-point reconnection. Only under restrictive assumptions is the slip velocity related to the gradient of the quasi potential (integral of parallel electric field along field lines). In a turbulent inertial range the curl becomes extremely large while the parallel component is tiny, so that line slippage occurs even while ideal MHD becomes accurate. The resolution of this paradox is that ideal MHD is valid for a turbulent inertial-range only in a weak sense which does not imply magnetic line freezing. The notion of weak solution i...

  10. Generalized simplicial chiral models

    CERN Document Server

    Alimohammadi, M

    2000-01-01

    Using the auxiliary field representation of the simplicial chiral models on a (d-1)-dimensional simplex, we generalize the simplicial chiral models by replacing the term Tr$(AA^{\\d})$ in the Lagrangian of these models, by an arbitrary class function of $AA^{\\d}; V(AA^{\\d})$. This is the same method that has been used in defining the generalized two-dimensional Yang-Mills theories (gYM_2) from ordinary YM_2. We call these models, the " generalized simplicial chiral models ". With the help of the results of one-link integral over a U(N) matrix, we compute the large-N saddle-point equations for eigenvalue density function $\\ro (z)$ in the weak ($\\b >\\b_c$) and strong ($\\b <\\b_c$) regions. In d=2, where the model somehow relates to gYM_2 theory, we solve the saddle-point equations and find $\\ro (z)$ in two region, and calculate the explicit value of critical point $\\b_c$ for $V(B)=TrB^n (B=AA^{\\d})$. For $V(B)=Tr B^2,Tr B^3$ and Tr$B^4$, we study the critical behaviour of the model at d=2, and by calculating t...

  11. General Relativity and Gravitation

    Science.gov (United States)

    Ashtekar, Abhay; Berger, Beverly; Isenberg, James; MacCallum, Malcolm

    2015-07-01

    Part I. Einstein's Triumph: 1. 100 years of general relativity George F. R. Ellis; 2. Was Einstein right? Clifford M. Will; 3. Cosmology David Wands, Misao Sasaki, Eiichiro Komatsu, Roy Maartens and Malcolm A. H. MacCallum; 4. Relativistic astrophysics Peter Schneider, Ramesh Narayan, Jeffrey E. McClintock, Peter Mészáros and Martin J. Rees; Part II. New Window on the Universe: 5. Receiving gravitational waves Beverly K. Berger, Karsten Danzmann, Gabriela Gonzalez, Andrea Lommen, Guido Mueller, Albrecht Rüdiger and William Joseph Weber; 6. Sources of gravitational waves. Theory and observations Alessandra Buonanno and B. S. Sathyaprakash; Part III. Gravity is Geometry, After All: 7. Probing strong field gravity through numerical simulations Frans Pretorius, Matthew W. Choptuik and Luis Lehner; 8. The initial value problem of general relativity and its implications Gregory J. Galloway, Pengzi Miao and Richard Schoen; 9. Global behavior of solutions to Einstein's equations Stefanos Aretakis, James Isenberg, Vincent Moncrief and Igor Rodnianski; Part IV. Beyond Einstein: 10. Quantum fields in curved space-times Stefan Hollands and Robert M. Wald; 11. From general relativity to quantum gravity Abhay Ashtekar, Martin Reuter and Carlo Rovelli; 12. Quantum gravity via unification Henriette Elvang and Gary T. Horowitz.

  12. Beyond generalized Proca theories

    Directory of Open Access Journals (Sweden)

    Lavinia Heisenberg

    2016-09-01

    Full Text Available We consider higher-order derivative interactions beyond second-order generalized Proca theories that propagate only the three desired polarizations of a massive vector field besides the two tensor polarizations from gravity. These new interactions follow the similar construction criteria to those arising in the extension of scalar–tensor Horndeski theories to Gleyzes–Langlois–Piazza–Vernizzi (GLPV theories. On the isotropic cosmological background, we show the existence of a constraint with a vanishing Hamiltonian that removes the would-be Ostrogradski ghost. We study the behavior of linear perturbations on top of the isotropic cosmological background in the presence of a matter perfect fluid and find the same number of propagating degrees of freedom as in generalized Proca theories (two tensor polarizations, two transverse vector modes, and two scalar modes. Moreover, we obtain the conditions for the avoidance of ghosts and Laplacian instabilities of tensor, vector, and scalar perturbations. We observe key differences in the scalar sound speed, which is mixed with the matter sound speed outside the domain of generalized Proca theories.

  13. Beyond generalized Proca theories

    Science.gov (United States)

    Heisenberg, Lavinia; Kase, Ryotaro; Tsujikawa, Shinji

    2016-09-01

    We consider higher-order derivative interactions beyond second-order generalized Proca theories that propagate only the three desired polarizations of a massive vector field besides the two tensor polarizations from gravity. These new interactions follow the similar construction criteria to those arising in the extension of scalar-tensor Horndeski theories to Gleyzes-Langlois-Piazza-Vernizzi (GLPV) theories. On the isotropic cosmological background, we show the existence of a constraint with a vanishing Hamiltonian that removes the would-be Ostrogradski ghost. We study the behavior of linear perturbations on top of the isotropic cosmological background in the presence of a matter perfect fluid and find the same number of propagating degrees of freedom as in generalized Proca theories (two tensor polarizations, two transverse vector modes, and two scalar modes). Moreover, we obtain the conditions for the avoidance of ghosts and Laplacian instabilities of tensor, vector, and scalar perturbations. We observe key differences in the scalar sound speed, which is mixed with the matter sound speed outside the domain of generalized Proca theories.

  14. General aviation in China

    Science.gov (United States)

    Hu, Xiaosi

    In the last four decades, China has accomplished economic reform successfully and grown to be a leading country in the world. As the "world factory", the country is able to manufacture a variety of industrial products from clothes and shoes to rockets and satellites. But the aviation industry has always been a weak spot and even the military relies on imported turbofan engines and jet fighters, not to mention the airlines. Recently China has launched programs such as ARJ21 and C919, and started reform to change the undeveloped situation of its aviation industry. As the foundation of the aviation industry, the development of general aviation is essential for the rise of commercial aviation. The primary goal of this study is to examine the general aviation industry and finds the issues that constrain the development of the industry in the system. The research method used in this thesis is the narrative research of qualitative approach since the policy instead of statistical data is analyzed. It appears that the main constraint for the general aviation industry is the government interference.

  15. Generalized Supersymetric Boundary State

    CERN Document Server

    Hashimoto, K

    2000-01-01

    Following our previous paper (hep-th/9909027), we generalize a supersymmetric boundary state so that arbitrary configuration of the gauge field coupled to the boundary of the worldsheet is incorpolated. This generalized boundary state is BRST invariant and satisfy the non-linear boundary conditions with non-constant gauge field strength. This boundary state contains divergence which is identical with the loop divergence in a superstring sigma model. Hence vanishing of the beta function in the superstring sigma model corresponds to a well-defined boundary state with no divergence. The coupling of a single closed superstring massless mode with multiple open string massless modes is encoded in the boundary state, and we confirm that derivative correction to the D-brane action in this sector vanishes up to the first non-trivial order O(alpha'(derivative)^2). Combining T-dualities, we incorpolate also general configurations of the scalar fields on the D-brane, and construct boundary states representing branes stuc...

  16. General minisum circle location

    DEFF Research Database (Denmark)

    Körner, Mark; Brimberg, Jack; Juel, Henrik

    2009-01-01

    In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points is minim......In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points...... is minimized, where the distance is measured by a norm k2. We present results for the general case. In the case that k1 and k2 are both block norms, we are able to identify a nite dominating set in R3 for the problem, which can be obtained as the intersection of cones....

  17. Hyperuniformity and its generalizations.

    Science.gov (United States)

    Torquato, Salvatore

    2016-08-01

    Disordered many-particle hyperuniform systems are exotic amorphous states of matter that lie between crystal and liquid: They are like perfect crystals in the way they suppress large-scale density fluctuations and yet are like liquids or glasses in that they are statistically isotropic with no Bragg peaks. These exotic states of matter play a vital role in a number of problems across the physical, mathematical as well as biological sciences and, because they are endowed with novel physical properties, have technological importance. Given the fundamental as well as practical importance of disordered hyperuniform systems elucidated thus far, it is natural to explore the generalizations of the hyperuniformity notion and its consequences. In this paper, we substantially broaden the hyperuniformity concept along four different directions. This includes generalizations to treat fluctuations in the interfacial area (one of the Minkowski functionals) in heterogeneous media and surface-area driven evolving microstructures, random scalar fields, divergence-free random vector fields, and statistically anisotropic many-particle systems and two-phase media. In all cases, the relevant mathematical underpinnings are formulated and illustrative calculations are provided. Interfacial-area fluctuations play a major role in characterizing the microstructure of two-phase systems (e.g., fluid-saturated porous media), physical properties that intimately depend on the geometry of the interface, and evolving two-phase microstructures that depend on interfacial energies (e.g., spinodal decomposition). In the instances of random vector fields and statistically anisotropic structures, we show that the standard definition of hyperuniformity must be generalized such that it accounts for the dependence of the relevant spectral functions on the direction in which the origin in Fourier space is approached (nonanalyticities at the origin). Using this analysis, we place some well-known energy

  18. Hyperuniformity and its generalizations

    Science.gov (United States)

    Torquato, Salvatore

    2016-08-01

    Disordered many-particle hyperuniform systems are exotic amorphous states of matter that lie between crystal and liquid: They are like perfect crystals in the way they suppress large-scale density fluctuations and yet are like liquids or glasses in that they are statistically isotropic with no Bragg peaks. These exotic states of matter play a vital role in a number of problems across the physical, mathematical as well as biological sciences and, because they are endowed with novel physical properties, have technological importance. Given the fundamental as well as practical importance of disordered hyperuniform systems elucidated thus far, it is natural to explore the generalizations of the hyperuniformity notion and its consequences. In this paper, we substantially broaden the hyperuniformity concept along four different directions. This includes generalizations to treat fluctuations in the interfacial area (one of the Minkowski functionals) in heterogeneous media and surface-area driven evolving microstructures, random scalar fields, divergence-free random vector fields, and statistically anisotropic many-particle systems and two-phase media. In all cases, the relevant mathematical underpinnings are formulated and illustrative calculations are provided. Interfacial-area fluctuations play a major role in characterizing the microstructure of two-phase systems (e.g., fluid-saturated porous media), physical properties that intimately depend on the geometry of the interface, and evolving two-phase microstructures that depend on interfacial energies (e.g., spinodal decomposition). In the instances of random vector fields and statistically anisotropic structures, we show that the standard definition of hyperuniformity must be generalized such that it accounts for the dependence of the relevant spectral functions on the direction in which the origin in Fourier space is approached (nonanalyticities at the origin). Using this analysis, we place some well-known energy

  19. Robotics and general surgery.

    Science.gov (United States)

    Jacob, Brian P; Gagner, Michel

    2003-12-01

    Robotics are now being used in all surgical fields, including general surgery. By increasing intra-abdominal articulations while operating through small incisions, robotics are increasingly being used for a large number of visceral and solid organ operations, including those for the gallbladder, esophagus, stomach, intestines, colon, and rectum, as well as for the endocrine organs. Robotics and general surgery are blending for the first time in history and as a specialty field should continue to grow for many years to come. We continuously demand solutions to questions and limitations that are experienced in our daily work. Laparoscopy is laden with limitations such as fixed axis points at the trocar insertion sites, two-dimensional video monitors, limited dexterity at the instrument tips, lack of haptic sensation, and in some cases poor ergonomics. The creation of a surgical robot system with 3D visual capacity seems to deal with most of these limitations. Although some in the surgical community continue to test the feasibility of these surgical robots and to question the necessity of such an expensive venture, others are already postulating how to improve the next generation of telemanipulators, and in so doing are looking beyond today's horizon to find simpler solutions. As the robotic era enters the world of the general surgeon, more and more complex procedures will be able to be approached through small incisions. As technology catches up with our imaginations, robotic instruments (as opposed to robots) and 3D monitoring will become routine and continue to improve patient care by providing surgeons with the most precise, least traumatic ways of treating surgical disease.

  20. Meeting Generalized Others

    DEFF Research Database (Denmark)

    Strøbæk, Pernille Solveig; Willert, Søren

    2014-01-01

    with different pre-merger backgrounds. Our findings suggest that analyzing dominant material discourse themes may throw light on the way work teams define and regulate their social practice, and, hence, that such analyses may be useful tools for studying the social dynamics of materiality and agency......Following George Herbert Mead, we contend that work-related organizational behavior requires continued negotiation of meaning – using linguistic, behavioral, and social tools. The meaning structures of the Generalized Other(s) of a particular employing organization provide the regulatory framework...

  1. Generalized L systems

    Institute of Scientific and Technical Information of China (English)

    陆汝钤; 张文妍

    2002-01-01

    This paper proposes the concept of generalized L systems, GL systems for short, which can describe asynchronized concurrent phenomena. We have proved that the GL systems are proper extensions of the traditional L systems. We have also defined a classification of GL systems and proved a sufficient and necessary condition for the equivalence of two subclasses of GL systems: two quivalent, iff k = j and there exists a common divisor g of all mr and a common divisor h of all ni such that i: mi/g = ni/h.

  2. General engineering knowledge

    CERN Document Server

    Mcgeorge, H D

    2012-01-01

    This book covers the general engineering knowledge required by candidates for the Department of Transport's Certificates of Competency in Marine Engineering, Class One and Class Two. The text is updated throughout in this third edition, and new chapters have been added on production of fresh water and on noise and vibration. Reference is also provided to up-to-date papers and official publications on specialized topics. These updates ensure that this little volume will continue to be a useful pre-examination and revision text. - Marine Engineers Review, January 1992

  3. General vorticity conservation

    CERN Document Server

    Gümral, H

    1998-01-01

    The motion of an incompressible fluid in Lagrangian coordinates involves infinitely many symmetries generated by the left Lie algebra of group of volume preserving diffeomorphisms of the three dimensional domain occupied by the fluid. Utilizing a 1+3-dimensional Hamiltonian setting an explicit realization of this symmetry algebra and the related Lagrangian and Eulerian conservation laws are constructed recursively. Their Lie algebraic structures are inherited from the same construction. The laws of general vorticity and helicity conservations are formulated globally in terms of invariant differential forms of the velocity field.

  4. Itch Management: General Principles.

    Science.gov (United States)

    Misery, Laurent

    2016-01-01

    Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental.

  5. Nonlocal General Relativity

    CERN Document Server

    Mashhoon, B

    2014-01-01

    A brief account of the present status of the recent nonlocal generalization of Einstein's theory of gravitation is presented. The main physical assumptions that underlie this theory are described. We clarify the physical meaning and significance of Weitzenb\\"ock's torsion, and emphasize its intimate relationship with the gravitational field, characterized by the Riemannian curvature of spacetime. In this theory, nonlocality can simulate dark matter; in fact, in the Newtonian regime, we recover the phenomenological Tohline-Kuhn approach to modified gravity. To account for the observational data regarding dark matter, nonlocality is associated with a characteristic length scale of order 1 kpc. The confrontation of nonlocal gravity with observation is briefly discussed.

  6. Generalized Supersymmetric Perturbation Theory

    Institute of Scientific and Technical Information of China (English)

    B. G(o)n(ǖ)l

    2004-01-01

    @@ Using the basic ingredient of supersymmetry, a simple alternative approach is developed to perturbation theory in one-dimensional non-relativistic quantum mechanics. The formulae for the energy shifts and wavefunctions do not involve tedious calculations which appear in the available perturbation theories. The model applicable in the same form to both the ground state and excited bound states, unlike the recently introduced supersymmetric perturbation technique which, together with other approaches based on logarithmic perturbation theory, are involved within the more general framework of the present formalism.

  7. Multiparticle Generalization of Teleportation

    Institute of Scientific and Technical Information of China (English)

    YANG Chui-Ping; GUO Guang-Can

    2000-01-01

    A scheme for teleporting an unknown quantum state of many particles is proposed. The scheme operates es sentially by prearranging the sharing of an Einstein-Podolsky-Rosen-correlated pair of particles every time. We show that after performing a series of Bell-state measurements and single-particle unitary transformations, the unknown state of many particles, which was destroyed at one place, can be reconstructed at another place. Our scheme is actually obtained by generalizing an earlier scheme of Bennett et al. [Phys. Rev. Lett. 70 (1993) 1895; 76 (1996) 722] known as quantum teleportation to the multiparticle case.

  8. The Pico's formula Generalization

    OpenAIRE

    Sergiu Cataranciuc; Marina Holban

    2007-01-01

    The Pico formula generalizations are obtained for area calculation of a polygon P through the determination of special nodes of the network in which this P is placed. The case of the polygon with rational coordinates of its vertexes is examined, as well as the case of the polygon with holes. In the case of three-dimensional space a formula of volume calculation for some polyhedrons, such as prism and tetrahedron is presented. On the basis of theoretic outcomes an algorithm that can be applied...

  9. The generalized Fubini instanton

    Energy Technology Data Exchange (ETDEWEB)

    Yurova, A.A. [Department of Higher Mathematics, Kaliningrad State Technical University, 236000, Soviet Avenue 1, Kaliningrad (Russian Federation)], E-mail: yurov@freemail.ru; Yurov, A.V. [Department of Theoretical Physics, Russian State University of I. Kant, 236041, Aleksandra Nevskogo street 14, Kaliningrad (Russian Federation)], E-mail: artyom_yurov@mail.ru

    2008-06-02

    We show that (1+2) nonlinear Klein-Gordon equation with negative coupling admits an exact solution which appears to be the linear superposition of the plane wave and the nonsingular rational soliton. We show that the same approach allows to construct the solution of similar properties for the Euclidean {phi}{sup 4} model with broken symmetry. Interestingly, this regular solution will be of instanton type only in the D{<=}5 Euclidean space. Thus one can use the generalized Fubini instantons (in quantum cosmology for example) only for the case of the single infinite extra dimension.

  10. Generalized Superfield Lagrangian Quantization

    CERN Document Server

    Lavrov, P M; Moshin, P Y

    2002-01-01

    We consider an extension of the gauge-fixing procedure in the framework of the Lagrangian superfield BRST and BRST-antiBRST quantization schemes for arbitrary gauge theories, taking into account the possible ambiguity in the choice of the superfield antibracket. We show that this ambiguity is fixed by the algebraic properties of the antibracket and the form of the BRST and antiBRST transformations, realized in terms of superspace translations. The Ward identities related to the generalized gauge-fixing procedure are obtained.

  11. General purpose MDE tools

    Directory of Open Access Journals (Sweden)

    Juan Manuel Cueva Lovelle

    2008-12-01

    Full Text Available MDE paradigm promises to release developers from writing code. The basis of this paradigm consists in working at such a level of abstraction that will make it easyer for analysts to detail the project to be undertaken. Using the model described by analysts, software tools will do the rest of the task, generating software that will comply with customer's defined requirements. The purpose of this study is to compare general purpose tools available right now that enable to put in practice the principles of this paradigm and aimed at generating a wide variety of applications composed by interactive multimedia and artificial intelligence components.

  12. Directors General appointed

    CERN Multimedia

    1975-01-01

    At a special session on 21 March, presided over by P. Levaux, the Council of the European Organization for Nuclear Research appointed J . B. Adams and L . Van Hove as Directors General of the Organization for a period of five years beginning 1 January 1976. Dr. Adams will be responsible for the administration of CERN, for the operation of the equipment and services and for the construction of buildings and major equipment. Professor Van Hove will be responsible for the research activities of the Organization.

  13. Generalized Quantum Current Algebras

    Institute of Scientific and Technical Information of China (English)

    ZHAO Liu

    2001-01-01

    Two general families of new quantum-deformed current algebras are proposed and identified both as infinite Hopf family of algebras, a structure which enables one to define "tensor products" of these algebras. The standard quantum affine algebras turn out to be a very special case of the two algebra families, in which case the infinite Hopf family structure degenerates into a standard Hopf algebra. The relationship between the two algebraic families as well as thefr various special examples are discussed, and the free boson representation is also considered.

  14. On generalized Volterra systems

    Science.gov (United States)

    Charalambides, S. A.; Damianou, P. A.; Evripidou, C. A.

    2015-01-01

    We construct a large family of evidently integrable Hamiltonian systems which are generalizations of the KM system. The algorithm uses the root system of a complex simple Lie algebra. The Hamiltonian vector field is homogeneous cubic but in a number of cases a simple change of variables transforms such a system to a quadratic Lotka-Volterra system. We present in detail all such systems in the cases of A3, A4 and we also give some examples from higher dimensions. We classify all possible Lotka-Volterra systems that arise via this algorithm in the An case.

  15. Generalized estimating equations

    CERN Document Server

    Hardin, James W

    2013-01-01

    Generalized Estimating Equations, Second Edition updates the best-selling previous edition, which has been the standard text on the subject since it was published a decade ago. Combining theory and application, the text provides readers with a comprehensive discussion of GEE and related models. Numerous examples are employed throughout the text, along with the software code used to create, run, and evaluate the models being examined. Stata is used as the primary software for running and displaying modeling output; associated R code is also given to allow R users to replicat

  16. The Pico's formula Generalization

    Directory of Open Access Journals (Sweden)

    Sergiu Cataranciuc

    2007-04-01

    Full Text Available The Pico formula generalizations are obtained for area calculation of a polygon P through the determination of special nodes of the network in which this P is placed. The case of the polygon with rational coordinates of its vertexes is examined, as well as the case of the polygon with holes. In the case of three-dimensional space a formula of volume calculation for some polyhedrons, such as prism and tetrahedron is presented. On the basis of theoretic outcomes an algorithm that can be applied in calculation for areas of plane figure is elaborated.

  17. GENERALIZED NEKRASOV MATRICES AND APPLICATIONS

    Institute of Scientific and Technical Information of China (English)

    Mingxian Pang; Zhuxiang Li

    2003-01-01

    In this paper, the concept of generalized Nekrasov matrices is introduced, some properties of these matrices are discussed, obtained equivalent representation of generalized diagonally dominant matrices.

  18. Generalized Nonlinear Yule Models

    Science.gov (United States)

    Lansky, Petr; Polito, Federico; Sacerdote, Laura

    2016-10-01

    With the aim of considering models related to random graphs growth exhibiting persistent memory, we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macroevolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth rates. Among the main results we derive the explicit distribution of the number of in-links of a webpage chosen uniformly at random recognizing the contribution to the asymptotics and the finite time correction. The mean value of the latter distribution is also calculated explicitly in the most general case. Furthermore, in order to show the usefulness of our results, we particularize them in the case of specific birth rates giving rise to a saturating behaviour, a property that is often observed in nature. The further specialization to the non-fractional case allows us to extend the Yule model accounting for a nonlinear growth.

  19. General Composite Higgs Models

    CERN Document Server

    Marzocca, David; Shu, Jing

    2012-01-01

    We construct a general class of pseudo-Goldstone composite Higgs models, within the minimal $SO(5)/SO(4)$ coset structure, that are not necessarily of moose-type. We characterize the main properties these models should have in order to give rise to a Higgs mass at around 125 GeV. We assume the existence of relatively light and weakly coupled spin 1 and 1/2 resonances. In absence of a symmetry principle, we introduce the Minimal Higgs Potential (MHP) hypothesis: the Higgs potential is assumed to be one-loop dominated by the SM fields and the above resonances, with a contribution that is made calculable by imposing suitable generalizations of the first and second Weinberg sum rules. We show that a 125 GeV Higgs requires light, often sub-TeV, fermion resonances. Their presence can also be important for the model to successfully pass the electroweak precision tests. Interestingly enough, the latter can be passed also by models with a heavy Higgs around 320 GeV. The composite Higgs models of the moose-type conside...

  20. Generalized Nonlinear Yule Models

    Science.gov (United States)

    Lansky, Petr; Polito, Federico; Sacerdote, Laura

    2016-11-01

    With the aim of considering models related to random graphs growth exhibiting persistent memory, we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macroevolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth rates. Among the main results we derive the explicit distribution of the number of in-links of a webpage chosen uniformly at random recognizing the contribution to the asymptotics and the finite time correction. The mean value of the latter distribution is also calculated explicitly in the most general case. Furthermore, in order to show the usefulness of our results, we particularize them in the case of specific birth rates giving rise to a saturating behaviour, a property that is often observed in nature. The further specialization to the non-fractional case allows us to extend the Yule model accounting for a nonlinear growth.

  1. Ordinary General Assembly

    CERN Document Server

    Staff Association

    2011-01-01

    Tuesday 12 April at 14.00 Council Chamber, Bldg 503 In conformity with the Statutes of the Staff Association, an ordinary General Assembly is organized once a year (article IV.2.1). Agenda   Adoption of the Agenda Approval of the Draft Minutes of the Ordinary General Assembly of 20 April 2010 Presentation and approval of the Activity Report 2010 Presentation and approval of the Financial Report 2010 Presentation and approval of the Auditors Report 2010 Programme for 2011 Presentation and approval of the draft budget and subscription rate 2012 Election of the Election Committee Election of the Board of Auditors Miscellaneous We remind members of article IV.3.4 in the Statutes of the Association which reads: “After having dealt with all the items on the agenda, the members may, with the consent of the Assembly, have other matters discussed, but decisions may be taken only on the items listed on the agenda. Nevertheless, the Assembly may r...

  2. Ordinary General Assembly

    CERN Multimedia

    Association du personnel

    2010-01-01

    Tuesday 20 April at 10.00 Council Chamber, Bldg 503 In conformity with the Statutes of the Staff Association, an ordinary General Assembly is organized once a year (article IV.2.1). Agenda Adoption of the Agenda Approval of the Draft Minutes of the Ordinary General Assembly of 12 May 2009 Presentation and approval of the Activity Report 2009 Presentation and approval of the Financial Report 2009 Presentation and approval of the Auditors Report 2009 Programme for 2010 Presentation et and approval of the draft budget and subscription rate 2010 Modifications to the statutes of the association Election of the Election Committee Election of the Board of Auditors Miscellaneous We remind members of article IV.3.4 in the Statutes of the Association which reads: “After having dealt with all the items on the agenda, the members may, with the consent of the Assembly, have other matters discussed, but decisions may be taken only on the items listed on the agenda...

  3. Ordinary General Assembly

    CERN Multimedia

    Staff Association

    2011-01-01

    Tuesday 12 April at 14.00 Council Chamber, Bldg 503 In conformity with the Statutes of the Staff Association, an ordinary General Assembly is organized once a year (article IV.2.1). Agenda   Adoption of the Agenda Approval of the Draft Minutes of the Ordinary General Assembly of 20 April 2010 Presentation and approval of the Activity Report 2010 Presentation and approval of the Financial Report 2010 Presentation and approval of the Auditors Report 2010 Programme for 2011 Presentation et and approval of the draft budget and subscription rate 2012 Election of the Election Committee Election of the Board of Auditors Miscellaneous We remind members of article IV.3.4 in the Statutes of the Association which reads: “After having dealt with all the items on the agenda, the members may, with the consent of the Assembly, have other matters discussed, but decisions may be taken only on the items listed on the agenda. Nevertheless, the Assembly ma...

  4. Ordinary General Assembly

    CERN Multimedia

    Staff Association

    2010-01-01

    Tuesday 20 April at 10.00 Council Chamber, Bldg 503 In conformity with the Statutes of the Staff Association, an ordinary General Assembly is organized once a year (article IV.2.1). Agenda   Adoption of the Agenda Approval of the Draft Minutes of the Ordinary General Assembly of 12 May 2009 Presentation and approval of the Activity Report 2009 Presentation and approval of the Financial Report 2009 Presentation and approval of the Auditors Report 2009 Programme for 2010 Presentation et and approval of the draft budget and subscription rate 2010 Election of the Election Committee Election of the Board of Auditors Miscellaneous We remind members of article IV.3.4 in the Statutes of the Association which reads: “After having dealt with all the items on the agenda, the members may, with the consent of the Assembly, have other matters discussed, but decisions may be taken only on the items listed on the agenda. Nevertheless, the Assembly may require t...

  5. Generalized etale cohomology theories

    CERN Document Server

    Jardine, John F

    1997-01-01

    A generalized etale cohomology theory is a theory which is represented by a presheaf of spectra on an etale site for an algebraic variety, in analogy with the way an ordinary spectrum represents a cohomology theory for spaces. Examples include etale cohomology and etale K-theory. This book gives new and complete proofs of both Thomason's descent theorem for Bott periodic K-theory and the Nisnevich descent theorem. In doing so, it exposes most of the major ideas of the homotopy theory of presheaves of spectra, and generalized etale homology theories in particular. The treatment includes, for the purpose of adequately dealing with cup product structures, a development of stable homotopy theory for n-fold spectra, which is then promoted to the level of presheaves of n-fold spectra.   This book should be of interest to all researchers working in fields related to algebraic K-theory. The techniques presented here are essentially combinatorial, and hence algebraic. An extensive background in traditional stable hom...

  6. Generalized Orthogonal Matching Pursuit

    CERN Document Server

    Wang, Jian; Shim, Byonghyo

    2011-01-01

    As a greedy algorithm to recover sparse signals from compressed measurements, the orthogonal matching pursuit (OMP) algorithm has received much attention in recent years. In this paper, we introduce an extension of the orthogonal matching pursuit (gOMP) for pursuing efficiency in reconstructing sparse signals. Our approach, henceforth referred to as generalized OMP (gOMP), is literally a generalization of the OMP in the sense that multiple indices are identified per iteration. Owing to the selection of multiple "correct" indices, the gOMP algorithm is finished with much smaller number of iterations compared to the OMP. We show that the gOMP can perfectly reconstruct any $K$-sparse signals ($K > 1$), provided that the sensing matrix satisfies the RIP with $\\delta_{NK} < \\frac{\\sqrt{N}}{\\sqrt{K} + 2 \\sqrt{N}}$. We also demonstrate by empirical simulations that the gOMP has excellent recovery performance comparable to $\\ell_1$-minimization technique with fast processing speed and competitive computational com...

  7. [Congenital cataract: general review].

    Science.gov (United States)

    Roche, O; Beby, F; Orssaud, C; Dupont Monod, S; Dufier, J L

    2006-04-01

    Cataract is a loss of lens transparency because of a protein alteration. Etiopathogenesis is poorly understood but new mutations of different developmental genes involved are found in 25% of cases. Frequency of onset, particularly when different ocular development anomalies occur, is related to the lens induction phenomena on the eye's anterior segment structure during embryologic development. Genetic transmission is often found on the dominant autosomal mode. Diagnosis is based on a complete and detailed examination of the eye, often with general anaesthesia. This condition predisposes children to later, sometimes serious amblyopia. Different clinical aspects can be observed: from cataract with ocular and/or systemic anomalies to polymalformative syndrome, skeletal, dermatological, neurological, metabolic, and genetic or chromosomal diseases. A general systematic pediatric examination is necessary. Congenital cataract requires first and foremost early diagnosis and a search for all etiologies. Surgical treatment is adapted case by case but it has progressed with the quality of today's intraocular lenses even if systematic implantation continues to be debated. Life-long monitoring is absolutely necessary.

  8. Generalized Agile Estimation Method

    Directory of Open Access Journals (Sweden)

    Shilpa Bahlerao

    2011-01-01

    Full Text Available Agile cost estimation process always possesses research prospects due to lack of algorithmic approaches for estimating cost, size and duration. Existing algorithmic approach i.e. Constructive Agile Estimation Algorithm (CAEA is an iterative estimation method that incorporates various vital factors affecting the estimates of the project. This method has lots of advantages but at the same time has some limitations also. These limitations may due to some factors such as number of vital factors and uncertainty involved in agile projects etc. However, a generalized agile estimation may generate realistic estimates and eliminates the need of experts. In this paper, we have proposed iterative Generalized Estimation Method (GEM and presented algorithm based on it for agile with case studies. GEM  based algorithm various project domain classes and vital factors with prioritization level. Further, it incorporates uncertainty factor to quantify the risk of project for estimating cost, size and duration. It also provides flexibility to project managers for deciding on number of vital factors, uncertainty level and project domains thereby maintaining the agility.

  9. ANNUAL GENERAL ASSEMBLY

    CERN Multimedia

    2001-01-01

    All members and beneficiaries of the Pension Fund are invited to attend the Annual General Asssembly to be held in the CERN Auditorium on Wednesday 3 October 2001 at 14.30 hrs The Agenda comprises:   Opening Remarks (P. Levaux) Some aspects of risk in a pension fund (C. Cuénoud) Annual Report 2000: Presentation and results (C. Cuénoud) Copies of the Report are available from divisional secretariats. Results of the actuarial reviews (G. Maurin) Questions from members and beneficiaries Persons wishing to ask questions are encouraged to submit them, where possible, in writing in advance, addressed to Mr C. Cuénoud, Administrator of the Fund. Conclusions (P. Levaux) As usual, participants are invited to drinks after the assembly. NB The minutes of the 2000 General Assembly are available from the Administration of the Fund (tel. + 41 22 767 91 94; e-mail Graziella.Praire@cern.ch) The English version will be published next week.

  10. Generalizing Minimal Supergravity

    CERN Document Server

    Li, Tianjun

    2010-01-01

    In Grand Unified Theories (GUTs), the Standard Model (SM) gauge couplings need not be unified at the GUT scale due to the high-dimensional operators. Considering gravity mediated supersymmetry breaking, we study for the first time the generic gauge coupling relations at the GUT scale, and the general gaugino mass relations which are valid from the GUT scale to the electroweak scale at one loop. We define the index k for these relations, which can be calculated in GUTs and can be determined at the Large Hadron Collider and the future International Linear Collider. Thus, we give a concrete definition of the GUT scale in these theories, and suggest a new way to test general GUTs at future experiments. We also discuss five special scenarios with interesting possibilities. With our generic formulae, we present all the GUT-scale gauge coupling relations and all the gaugino mass relations in the SU(5) and SO(10) models, and calculate the corresponding indices k. Especially, the index k is 5/3 in the traditional SU(5...

  11. Conditional generalized analytic Feynman integrals and a generalized integral equation

    OpenAIRE

    Seung Jun Chang; Soon Ja Kang; David Skoug

    2000-01-01

    We use a generalized Brownian motion process to define a generalized Feynman integral and a conditional generalized Feynman integral. We then establish the existence of these integrals for various functionals. Finally we use the conditional generalized Feynman integral to derive a Schrödinger integral equation.

  12. Introduction to general relativity

    CERN Document Server

    Parthasarthy, R

    2016-01-01

    INTRODUCTION TO GENERAL RELATIVITY begins with a description of the geometry of curved space, explaining geodesics, parallel transport, covariant differentiation, geodesic deviation and spacetime symmetry by killing vectors. It then introduces Einstein's theory of gravitation followed by Schwarzschild solution with its relevance to Positive Mass theorem. The three tests for Einstein's gravity are explained. Other exact solutions such as Vaidya, Kerr and Reisner - Nordstrom metric are included. In the Chapter on cosmological solutions, a detailed description of Godel metric is provided. It then introduces five dimensional spacetime of Kaluza showing the unification of gravity with electromagnetism. This is extended to include non-Abelian gauge theory by invoking compact extra dimensions. Explicit expressions in this case for Christoffel connections and ricci tensor are derived and the higher dimensional gravity action is shown to compactification are given.

  13. Beyond Einstein's General Relativity

    CERN Document Server

    Lobo, Francisco S N

    2014-01-01

    Modern astrophysical and cosmological models are plagued with two severe theoretical difficulties, namely, the dark energy and the dark matter problems. Relative to the former, high-precision observational data have confirmed with startling evidence that the Universe is undergoing a phase of accelerated expansion. This phase, one of the most important and challenging current problems in cosmology, represents a new imbalance in the governing gravitational equations. Several candidates, responsible for this expansion, have been proposed in the literature, in particular, dark energy models and modified gravity, amongst others. Outstanding questions are related to the nature of this so-called "dark energy" that is driving the acceleration of the universe, and whether it is due to the vacuum energy or a dynamical field. On the other hand, the late-time cosmic acceleration may be due to modifications of General Relativity, which introduce new degrees of freedom to the gravitational sector itself. We analyze some of...

  14. Nanotechnologies a general introduction

    CERN Document Server

    CERN. Geneva; Ferrari, M; Li Bassi, A

    2007-01-01

    After a brief description of what is nanotechnology (a triple definition will be attempted) and of its importance for the society, this first lecture manly aims at showing how nanoscience makes various nanotechnologies possible. The surprising story of direct imaging and manipulation of atoms (scanning probe microscopies will be the specific subject of the third lecture by prof. Andrea Li Bassi) is told to naturally introduce the crucial role of quantum confinement and surface defects. The electronic and vibrational properties of nanostructures are then discussed to understand the connection between the deeply modified (with respect to the bulk) quantum spectra and the physico-chemical properties of nanoscopic objects. In this context the concept of superatom (and its generalizations) is stressed. The essential role of both size and size control is finally emphasized discussing some significant applications in the fields of materials, devices and medicine. To this last argument (nanomedicine) the second lectu...

  15. Generalized channeled polarimetry.

    Science.gov (United States)

    Alenin, Andrey S; Tyo, J Scott

    2014-05-01

    Channeled polarimeters measure polarization by modulating the measured intensity in order to create polarization-dependent channels that can be demodulated to reveal the desired polarization information. A number of channeled systems have been described in the past, but their proposed designs often unintentionally sacrifice optimality for ease of algebraic reconstruction. To obtain more optimal systems, a generalized treatment of channeled polarimeters is required. This paper describes methods that enable handling of multi-domain modulations and reconstruction of polarization information using linear algebra. We make practical choices regarding use of either Fourier or direct channels to make these methods more immediately useful. Employing the introduced concepts to optimize existing systems often results in superficial system changes, like changing the order, orientation, thickness, or spacing of polarization elements. For the two examples we consider, we were able to reduce noise in the reconstruction to 34.1% and 57.9% of the original design values.

  16. GENERALIZED DOUBLE PARETO SHRINKAGE.

    Science.gov (United States)

    Armagan, Artin; Dunson, David B; Lee, Jaeyong

    2013-01-01

    We propose a generalized double Pareto prior for Bayesian shrinkage estimation and inferences in linear models. The prior can be obtained via a scale mixture of Laplace or normal distributions, forming a bridge between the Laplace and Normal-Jeffreys' priors. While it has a spike at zero like the Laplace density, it also has a Student's t-like tail behavior. Bayesian computation is straightforward via a simple Gibbs sampling algorithm. We investigate the properties of the maximum a posteriori estimator, as sparse estimation plays an important role in many problems, reveal connections with some well-established regularization procedures, and show some asymptotic results. The performance of the prior is tested through simulations and an application.

  17. Generalized Wideband Cyclic MUSIC

    Directory of Open Access Journals (Sweden)

    Zhang-Meng Liu

    2009-01-01

    Full Text Available The method of Spectral Correlation-Signal Subspace Fitting (SC-SSF fails to separate wideband cyclostationary signals with coherent second-order cyclic statistics (SOCS. Averaged Cyclic MUSIC (ACM method made up for the drawback to some degree via temporally averaging the cyclic cross-correlation of the array output. This paper interprets ACM from another perspective and proposes a new DOA estimation method by generalizing ACM for wideband cyclostationary signals. The proposed method successfully makes up for the aforementioned drawback of SC-SSF and obtains a more satisfying performance than ACM. It is also demonstrated that ACM is a simplified form of the proposed method when only a single spectral frequency is exploited, and the integration of the frequencies within the signal bandwidth helps the new method to outperform ACM.

  18. General human activity patterns

    CERN Document Server

    Mollgaard, Anders; Mathiesen, Joachim

    2016-01-01

    We investigate the dynamics and interplay between human communication, movement, and social proximity by analyzing data collected from smartphones distributed among 638 individuals. The main question we consider is: to what extent do individuals act according to patterns shared across an entire population? Based on statistics of the entire population, we successfully predict 71\\% of the activity and 85\\% of the inactivity involved in communication, movement, and social proximity. We find that individual level statistics only result in marginally better predictions, indicating a high degree of shared activity patterns across the population. Finally, we predict short-term activity patterns using a generalized linear model, which suggests that a simple linear description might be sufficient to explain a wide range of actions, whether they be of social or of physical character.

  19. Natural generalized mirage mediation

    CERN Document Server

    Baer, Howard; Serce, Hasan; Tata, Xerxes

    2016-01-01

    In the supersymmetric scenario known as mirage mediation (MM), the soft SUSY breaking terms receive comparable anomaly-mediation and moduli-mediation contributions leading to the phenomenon of mirage unification. The simplest MM SUSY breaking models which are consistent with the measured Higgs mass and sparticle mass constraints are strongly disfavoured by fine-tuning considerations. However, while MM makes robust predictions for gaugino masses, the scalar sector is quite sensitive to specific mechanisms for moduli stabilization and potential uplifting. We suggest here a broader setup of generalized mirage mediation (GMM), where heretofore discrete parameters are allowed as continuous to better parametrize these other schemes. We find that natural SUSY spectra consistent with both the measured value of m(h). as well as LHC lower bounds on superpartner masses are then possible. We explicitly show that models generated from natural GMM may be beyond the reach of even high-luminosity LHC searches. In such a case...

  20. Deformed General Relativity

    CERN Document Server

    Bojowald, Martin

    2013-01-01

    Deformed special relativity is embedded in deformed general relativity using the methods of canonical relativity and loop quantum gravity. Phase-space dependent deformations of symmetry algebras then appear, which in some regimes can be rewritten as non-linear Poincare algebras with momentum-dependent deformations of commutators between boosts and time translations. In contrast to deformed special relativity, the deformations are derived for generators with an unambiguous physical role, following from the relationship between canonical constraints of gravity with stress-energy components. The original deformation does not appear in momentum space and does not give rise to non-locality issues or problems with macroscopic objects. Contact with deformed special relativity may help to test loop quantum gravity or restrict its quantization ambiguities.

  1. Generalized mid dermal elastolysis

    Directory of Open Access Journals (Sweden)

    Maria João Cruz

    2011-12-01

    Full Text Available Mid-dermal elastolysis (MDE is a rare skin disorder clinically characterized by the appearance of diffuse fine wrinkling, most often of the trunk and arms. This entity is distinguished from other elastolytic disorders by its characteristic selective loss of elastic fibers of the mid dermis. The aetiopathogenesis of the disease is still unclear as well as the effective treatment. Half of the cases described in the literature are associated with ultraviolet radiation exposure. Other reported triggering conditions such as urticaria, eczema and granuloma annulare suggests different eliciting inflammatory pathways. The authors describe the case of a 38-year-old woman who developed an urticarial eruption during months which progressed to generalized and severe fine wrinkling.

  2. Generalizing Giuga's conjecture

    CERN Document Server

    Grau, José María

    2011-01-01

    In 1950 G. Giuga studied the congruence $\\sum_{j=1}^{n-1} j^{n-1} \\equiv -1$ (mod $n$) and conjectured that it was only satisfied by prime numbers. In this work we generalize Giuga's ideas considering, for each $k \\in \\mathbb{N}$, the congruence $\\sum_{j=1}^{n-1} j^{k(n-1)} \\equiv -1$ (mod $n$). It particular, it is proved that a pair $(n,k)\\in \\mathbb{N}^2$ (with composite $n$) satisfies the congruence if and only if $n$ is a Giuga Number and $ \\lambda(n)/\\gcd(\\lambda(n),n-1)$ divides $k$. In passing, we establish some new characterizations of Giuga Numbers.

  3. Neutron stars - General review

    Science.gov (United States)

    Cameron, A. G. W.; Canuto, V.

    1974-01-01

    A review is presented of those properties of neutron stars upon which there is general agreement and of those areas which currently remain in doubt. Developments in theoretical physics of neutron star interiors are summarized with particular attention devoted to hyperon interactions and the structure of interior layers. Determination of energy states and the composition of matter is described for successive layers, beginning with the surface and proceeding through the central region into the core. Problems encountered in determining the behavior of matter in the ultra-high density regime are discussed, and the effects of the magnetic field of a neutron star are evaluated along with the behavior of atomic structures in the field. The evolution of a neutron star is outlined with discussion centering on carbon detonation, cooling, vibrational damping, rotation, and pulsar glitches. The role of neutron stars in cosmic-ray propagation is considered.

  4. Generalized exterior algebras

    CERN Document Server

    Marchuk, Nikolay

    2011-01-01

    Exterior algebras and differential forms are widely used in many fields of modern mathematics and theoretical physics. In this paper we define a notion of $N$-metric exterior algebra, which depends on $N$ matrices of structure constants. The usual exterior algebra (Grassmann algebra) can be considered as 0-metric exterior algebra. Clifford algebra can be considered as 1-metric exterior algebra. $N$-metric exterior algebras for $N\\geq2$ can be considered as generalizations of the Grassmann algebra and Clifford algebra. Specialists consider models of gravity that based on a mathematical formalism with two metric tensors. We hope that the considered in this paper 2-metric exterior algebra can be useful for development of this model in gravitation theory. Especially in description of fermions in presence of a gravity field.

  5. Awareness under general anesthesia.

    Science.gov (United States)

    Bischoff, Petra; Rundshagen, Ingrid

    2011-01-01

    Awareness while under general anesthesia, and the later recall of what happened during surgery, can be experienced by patients as horrific events that leave lasting mental trauma behind. Patients may have both auditory and tactile perception, potentially accompanied by feelings of helplessness, inability to move, pain, and panic ranging to an acute fear of death. For some patients, the experience of awareness under anesthesia has no sequelae; for others, however, it can lead to the development of post-traumatic stress disorder, consisting of complex psychopathological phenomena such as anxiety, insomnia, nightmares, irritability, and depression possibly leading to suicidality. The literature on the subject was selectively reviewed. In the absence of risk factors awareness phenomena occur in one to two per 1000 operations under general anesthesia (0.1% to 0.2%) and are thus classed as an occasionally occurring critical event. In children, the risk of such phenomena occurring is 8 to 10 times higher. These phenomena are due to an inadequate depth of anesthesia with incomplete unconsciousness. They can be promoted by a number of risk factors that are either patient-related (ASA class III or above, medication abuse), surgery-related (Caesarean section, emergency procedures, surgery at night), or anesthesia-related (anesthesia without benzodiazepines, use of muscle relaxants). Strategies for avoiding awareness phenomena under anesthesia include the training of staff to know about the problem and, specifically, the use of benzodiazepines, the avoidance of muscle relaxants if possible, and shielding the patient from excessive noise. EEG monitoring is effective but provides no guarantee against awareness. If awareness under anesthesia occurs despite these measures, the patient must be given expert, interdisciplinary treatment as soon after the event as possible in order to minimize its potential sequelae.

  6. Generalized conjugate gradient squared

    Energy Technology Data Exchange (ETDEWEB)

    Fokkema, D.R.; Sleijpen, G.L.G. [Utrecht Univ. (Netherlands)

    1994-12-31

    In order to solve non-symmetric linear systems of equations, the Conjugate Gradient Squared (CGS) is a well-known and widely used iterative method. In practice the method converges fast, often twice as fast as the Bi-Conjugate Gradient method. This is what you may expect, since CGS uses the square of the BiCG polynomial. However, CGS may suffer from its erratic convergence behavior. The method may diverge or the approximate solution may be inaccurate. BiCGSTAB uses the BiCG polynomial and a product of linear factors in an attempt to smoothen the convergence. In many cases, this has proven to be very effective. Unfortunately, the convergence of BiCGSTAB may stall when a linear factor (nearly) degenerates. BiCGstab({ell}) is designed to overcome this degeneration of linear factors. It generalizes BiCGSTAB and uses both the BiCG polynomial and a product of higher order factors. Still, CGS may converge faster than BiCGSTAB or BiCGstab({ell}). So instead of using a product of linear or higher order factors, it may be worthwhile to look for other polynomials. Since the BiCG polynomial is based on a three term recursion, a natural choice would be a polynomial based on another three term recursion. Possibly, a suitable choice of recursion coefficients would result in method that converges faster or as fast as CGS, but less erratic. It turns out that an algorithm for such a method can easily be formulated. One particular choice for the recursion coefficients leads to CGS. Therefore one could call this algorithm generalized CGS. Another choice for the recursion coefficients leads to BiCGSTAB. It is therefore possible to mix linear factors and some polynomial based on a three term recursion. This way one may get the best of both worlds. The authors will report on their findings.

  7. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, M. A. H.

    2014-08-05

    Internal multiples deteriorate the image when the imaging procedure assumes only single scattering, especially if the velocity model does not have sharp contrasts to reproduce such scattering in the Green’s function through forward modeling. If properly imaged, internal multiples (internally scattered energy) can enhance the seismic image. Conventionally, to image internal multiples, accurate, sharp contrasts in the velocity model are required to construct a Green’s function with all the scattered energy. As an alternative, we have developed a generalized internal multiple imaging procedure that images any order internal scattering using the background Green’s function (from the surface to each image point), constructed from a smooth velocity model, usually used for conventional imaging. For the first-order internal multiples, the approach consisted of three steps, in which we first back propagated the recorded surface seismic data using the background Green’s function, then crosscorrelated the back-propagated data with the recorded data, and finally crosscorrelated the result with the original background Green’s function. This procedure images the contribution of the recorded first-order internal multiples, and it is almost free of the single-scattering recorded energy. The cost includes one additional crosscorrelation over the conventional single-scattering imaging application. We generalized this method to image internal multiples of any order separately. The resulting images can be added to the conventional single-scattering image, obtained, e.g., from Kirchhoff or reverse-time migration, to enhance the image. Application to synthetic data with reflectors illuminated by multiple scattering (double scattering) demonstrated the effectiveness of the approach.

  8. General Randic matrix and general Randi'c energy

    Directory of Open Access Journals (Sweden)

    Ran Gu;

    2014-09-01

    Full Text Available Let $G$ be a simple graph with vertex set $V(G = {v_1, v_2,ldots , v_n}$ and $d_i$ the degree of its vertex $v_i$, $i = 1, 2, cdots, n$. Inspired by the Randi'c matrix and the general Randi'c index of a graph, we introduce the concept of general Randi'c matrix $textbf{R}_alpha$ of $G$, which is defined by $(textbf{R}_alpha_{i,j}=(d_id_j^alpha$ if $v_i$ and $v_j$ are adjacent, and zero otherwise. Similarly, the general Randi'{c} eigenvalues are the eigenvalues of the general Randi'{c} matrix, the greatest general Randi'{c} eigenvalue is the general Randi'{c} spectral radius of $G$, and the general Randi'{c} energy is the sum of the absolute values of the general Randi'{c} eigenvalues. In this paper, we prove some properties of the general Randi'c matrix and obtain lower and upper bounds for general Randi'{c} energy, also, we get some lower bounds for general Randi'{c} spectral radius of a connected graph. Moreover, we give a new sharp upper bound for the general Randi'{c} energy when $alpha=-1/2$.[2mm] noindent{bf Keywords:} general Randi'c matrix, general Randi'c energy, eigenvalues, spectral radius.

  9. Generalized Reactive Manufacturing System

    Institute of Scientific and Technical Information of China (English)

    李蓓智

    2001-01-01

    Generalized reactive manufacturing system named GRMS is introduced. GRMS is a human-centered system based on Multi-agent. Its management and control organization is made up of three types of agents named device agent,task agent and shop-floor agent. GRMS adopts a top down and bottom- up competition and cooperation strategy based on the dynamic sifter and funnel To constrain the behavior of agents, a reward and penaity policy is introduced into the system and the closed-loop adjustment of GRMS is realized through such policy.Agents for the same task should be cooperated with each other and agents for different tasks should compete for survival in the dynamic changing environment. A distributed-hierarchical architecture with three levels of master-slave relationships among agents are proposed.Self-propelled process planning is also discussed. In order to evaluate GRMS, a time-driven simulation system-GRMOSS is developed to check the physical consistency of GRMS.

  10. Adenotomy under general anesthesia.

    Science.gov (United States)

    Vokurka, J; Jakoubková, S; Vít, Z; Drahokoupilová, M

    1989-01-01

    Experience obtained from adenotomy (AT) under general anesthesia using Ketamin hydrochloride (Ketalar, Narkamon) in children are presented in this paper. The authors had used intramuscular premedication with Prothazin, Dolsin and Atropin at the first stage, then they shifted to oral administration of a combination of Diazepam, Theadryl and Atropin. Ketamin may be applied intravenously in the dosage of 1.0 to 1.5 mg/kg of body weight in most children. Where it is not possible, a triple dose into the muscle is used. A total of 2,266 AT were performed. About 70% of patients were calm during the operation, once a suspected aspiration was considered but it was not confirmed. The main contribution of the method is 100% amnesia of the surgery made. The procedure is a compromise between a requirement for minimal traumatization of the child's psyche by the intervention and the resources available, particularly the need of personnel at the majority of otorhinolaryngo-logical departments nowadays.

  11. Beurling generalized numbers

    CERN Document Server

    Diamond, Harold G; Cheung, Man Ping

    2016-01-01

    "Generalized numbers" is a multiplicative structure introduced by A. Beurling to study how independent prime number theory is from the additivity of the natural numbers. The results and techniques of this theory apply to other systems having the character of prime numbers and integers; for example, it is used in the study of the prime number theorem (PNT) for ideals of algebraic number fields. Using both analytic and elementary methods, this book presents many old and new theorems, including several of the authors' results, and many examples of extremal behavior of g-number systems. Also, the authors give detailed accounts of the L^2 PNT theorem of J. P. Kahane and of the example created with H. L. Montgomery, showing that additive structure is needed for proving the Riemann hypothesis. Other interesting topics discussed are propositions "equivalent" to the PNT, the role of multiplicative convolution and Chebyshev's prime number formula for g-numbers, and how Beurling theory provides an interpretation of the ...

  12. General purpose operator interface

    Energy Technology Data Exchange (ETDEWEB)

    Bennion, S. I.

    1979-07-01

    The Hanford Engineering Development Laboratory in Richland, Washington is developing a general-purpose operator interface for controlling set-point driven processes. The interface concept is being developed around graphics display devices with touch-sensitive screens for direct interaction with the displays. Additional devices such as trackballs and keyboards are incorporated for the operator's convenience, but are not necessary for operation. The hardware and software are modular; only those capabilities needed for a particular application need to be used. The software is written in FORTRAN IV with minimal use of operating system calls to increase portability. Several ASCII files generated by the user define displays and correlate the display variables with the process parameters. It is also necessary for the user to build an interface routine which translates the internal graphics commands into device-specific commands. The interface is suited for both continuous flow processes and unit operations. An especially useful feature for controlling unit operations is the ability to generate and execute complex command sequences from ASCII files. This feature relieves operators of many repetitive tasks. 2 figures.

  13. General Environment Of World

    Directory of Open Access Journals (Sweden)

    Dr. Mohammed Viquaruddin

    2012-11-01

    Full Text Available This paper is an attempt regarding the general social/economical/ecological/political and more environments of world certainly with multidisciplinary/interdisciplinary approach. It is discussed that the problems of fore further can besolved through facts/reasoning/science/environment/social sciences etc. As beinga student of political science even peace science a try that can come into existenceor can be practiced only through many dimensions. The philosophy is developedto resist with whatever means we have in hand and are willing to fight for a betterscenario which would be something out of our reach! But can achieve through apositive and plural system not certainly perfect but different in its approach.Achievement to the threats and problems to the liberal vision are pervasive and thesystem is in much greater problematic that is commonly supposed. Protecting/Preserving/ Commanding it in the coming century and beyond will be easier saidthan done! We do not foresee the renaissance of any type we should be sure aboutthat alternative World Multidimensional System (WMS could reasonably competewith the present multidimensional system on theoretical or practical grounds. It isnot enough that this system display substantial practical advantages and genuinetheoretical coherence. No one can deny that world get profit from present system.

  14. Generalized reduced magnetohydrodynamic equations

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, S.E.

    1999-02-01

    A new derivation of reduced magnetohydrodynamic (MHD) equations is presented. A multiple-time-scale expansion is employed. It has the advantage of clearly separating the three time scales of the problem associated with (1) MHD equilibrium, (2) fluctuations whose wave vector is aligned perpendicular to the magnetic field, and (3) those aligned parallel to the magnetic field. The derivation is carried out without relying on a large aspect ratio assumption; therefore this model can be applied to any general configuration. By accounting for the MHD equilibrium and constraints to eliminate the fast perpendicular waves, equations are derived to evolve scalar potential quantities on a time scale associated with the parallel wave vector (shear-Alfven wave time scale), which is the time scale of interest for MHD instability studies. Careful attention is given in the derivation to satisfy energy conservation and to have manifestly divergence-free magnetic fields to all orders in the expansion parameter. Additionally, neoclassical closures and equilibrium shear flow effects are easily accounted for in this model. Equations for the inner resistive layer are derived which reproduce the linear ideal and resistive stability criterion of Glasser, Greene, and Johnson. The equations have been programmed into a spectral initial value code and run with shear flow that is consistent with the equilibrium input into the code. Linear results of tearing modes with shear flow are presented which differentiate the effects of shear flow gradients in the layer with the effects of the shear flow decoupling multiple harmonics.

  15. Generalized Linear Covariance Analysis

    Science.gov (United States)

    Carpenter, James R.; Markley, F. Landis

    2014-01-01

    This talk presents a comprehensive approach to filter modeling for generalized covariance analysis of both batch least-squares and sequential estimators. We review and extend in two directions the results of prior work that allowed for partitioning of the state space into solve-for'' and consider'' parameters, accounted for differences between the formal values and the true values of the measurement noise, process noise, and textita priori solve-for and consider covariances, and explicitly partitioned the errors into subspaces containing only the influence of the measurement noise, process noise, and solve-for and consider covariances. In this work, we explicitly add sensitivity analysis to this prior work, and relax an implicit assumption that the batch estimator's epoch time occurs prior to the definitive span. We also apply the method to an integrated orbit and attitude problem, in which gyro and accelerometer errors, though not estimated, influence the orbit determination performance. We illustrate our results using two graphical presentations, which we call the variance sandpile'' and the sensitivity mosaic,'' and we compare the linear covariance results to confidence intervals associated with ensemble statistics from a Monte Carlo analysis.

  16. Conformal General Relativity

    CERN Document Server

    Pervushin, V

    2001-01-01

    The inflation-free solution of problems of the modern cosmology (horizon, cosmic initial data, Planck era, arrow of time, singularity,homogeneity, and so on) is considered in the conformal-invariant unified theory given in the space with geometry of similarity where we can measure only the conformal-invariant ratio of all quantities. Conformal General Relativity is defined as the $SU_c(3)\\times SU(2)\\times U(1)$-Standard Model where the dimensional parameter in the Higgs potential is replaced by a dilaton scalar field described by the negative Penrose-Chernikov-Tagirov action. Spontaneous SU(2) symmetry breaking is made on the level of the conformal-invariant angle of the dilaton-Higgs mixing, and it allows us to keep the structure of Einstein's theory with the equivalence principle. We show that the lowest order of the linearized equations of motion solves the problems mentioned above and describes the Cold Universe Scenario with the constant temperature T and z-history of all masses with respect to an obser...

  17. MEDEX: a general overview

    Directory of Open Access Journals (Sweden)

    A. Jansa

    2014-01-01

    Full Text Available The general objective of the international MEDiterranean EXperiment (MEDEX was the better understanding and forecasting of cyclones that produce high impact weather in the Mediterranean. This paper reviews the motivation and foundation of MEDEX, the gestation, history and organisation of the project, as well as the main products and scientific achievements obtained from it. MEDEX obtained the approval of WMO and can be considered as framed within other WMO actions, such as ALPEX, MCP and, to certain extent, THORPEX and HyMeX. Through two phases (2000–2005 and 2006–2010 MEDEX has produced a specific database, with information about cyclones and high impact weather events, several main reports and a specific field campaign (DTS-MEDEX-2009. The scientific achievements are significant in fields like climatology, dynamical understanding of the physical processes and social impact of cyclones, as well as on aspects related to the location of sensitive zones for individual cases, climatology of sensitivity zones and the improvement of the forecasts through innovative methods like mesoscale ensemble prediction systems.

  18. [General review of rhinolithiases].

    Science.gov (United States)

    Kharoubi, S

    2008-02-01

    The aim of this study was to analyze the clinical presentation and characteristics of rhinolithiasis, a rare and forgotten entity. Between 1990 and 2007, 20 cases of rhinolithiasis presented for consultation. The clinical course noted chronic nasal discharge associated with nasal obstruction. The protocol was the same for all patients: history of disease, meticulous endonasal endoscopy and plain radiography (+/-CT scan). Rhinolithiasis was found in adults (55%), females, patients living in rural areas (66%) with unfavorable socioeconomic conditions. The diagnosis delay varied between six months and eight years. The examination showed the rhinolith in the form of a grey concretion, primarily unilateral and on the right-hand side in 60% of the patients. Only one bilateral case presented following destruction of the posterior nasal septum. The rhinolith measured between 5 and 50mm in diameter with only three associated foreign bodies (15%). The rhinolith was extracted through the natural pathways under local anesthesia in 60% of the cases. Complications were rare (epistaxis 10%) and favorable progression without recurrence was generally observed after a mean 16 months of follow-up (range, six months to 11 years). Chronic nasal discharge without a history of rhinologic disease requires an endonasal examination under good conditions after retraction. Rhinolithiasis is easily recognized, in particular on imaging studies. Treatment is simple and curative in the majority of cases.

  19. MEDEX: a general overview

    Science.gov (United States)

    Jansa, A.; Alpert, P.; Arbogast, P.; Buzzi, A.; Ivancan-Picek, B.; Kotroni, V.; Llasat, M. C.; Ramis, C.; Richard, E.; Romero, R.; Speranza, A.

    2014-08-01

    The general objective of the international MEDiterranean EXperiment (MEDEX) was the better understanding and forecasting of cyclones that produce high impact weather in the Mediterranean. This paper reviews the motivation and foundation of MEDEX, the gestation, history and organisation of the project, as well as the main products and scientific achievements obtained from it. MEDEX obtained the approval of World Meteorological Organisation (WMO) and can be considered as framed within other WMO actions, such as the ALPine EXperiment (ALPEX), the Mediterranean Cyclones Study Project (MCP) and, to a certain extent, THe Observing System Research and Predictability EXperiment (THORPEX) and the HYdrological cycle in Mediterranean EXperiment (HyMeX). Through two phases (2000-2005 and 2006-2010), MEDEX has produced a specific database, with information about cyclones and severe or high impact weather events, several main reports and a specific data targeting system field campaign (DTS-MEDEX-2009). The scientific achievements are significant in fields like climatology, dynamical understanding of the physical processes and social impact of cyclones, as well as in aspects related to the location of sensitive zones for individual cases, the climatology of sensitivity zones and the improvement of the forecasts through innovative methods like mesoscale ensemble prediction systems.

  20. Generalized emissivity inverse problem.

    Science.gov (United States)

    Ming, DengMing; Wen, Tao; Dai, XianXi; Dai, JiXin; Evenson, William E

    2002-04-01

    Inverse problems have recently drawn considerable attention from the physics community due to of potential widespread applications [K. Chadan and P. C. Sabatier, Inverse Problems in Quantum Scattering Theory, 2nd ed. (Springer Verlag, Berlin, 1989)]. An inverse emissivity problem that determines the emissivity g(nu) from measurements of only the total radiated power J(T) has recently been studied [Tao Wen, DengMing Ming, Xianxi Dai, Jixin Dai, and William E. Evenson, Phys. Rev. E 63, 045601(R) (2001)]. In this paper, a new type of generalized emissivity and transmissivity inverse (GETI) problem is proposed. The present problem differs from our previous work on inverse problems by allowing the unknown (emissivity) function g(nu) to be temperature dependent as well as frequency dependent. Based on published experimental information, we have developed an exact solution formula for this GETI problem. A universal function set suggested for numerical calculation is shown to be robust, making this inversion method practical and convenient for realistic calculations.

  1. How General Is Holography?

    CERN Document Server

    Riegler, Max

    2016-01-01

    In this thesis I explore the generality of the holographic principle in 2+1 (bulk) dimensions by looking at the possibility of having holographic correspondences for non-AdS (higher-spin) spacetimes. The first part focuses on Lobachevsky spacetimes with $\\mathfrak{sl}(4,\\mathbb{R})$ as well as $\\mathcal{W}^{(2)}_N$ symmetries, the asymptotic symmetry algebras and their unitary representations. This results in a family of unitary $\\mathcal{W}^{(2)}_N$ models that can have both small and large central charge. The focus of the second part is a possible holographic correspondence in asymptotically flat spacetimes. This part covers limits from known AdS$_3$ results to flat space as well as a NO-GO result that forbids having flat space, higher-spins and unitarity at the same time. In addition this part shows how to consistently add (higher-spin) chemical potentials to flat space. As a non-trivial check of a holographic correspondence in flat space I provide a way to determine entanglement entropy (as well as therma...

  2. Generalized differential semblance optimization

    KAUST Repository

    Zhang, S.

    2013-06-10

    This paper inverts space-lags in the suboffset-domain CIGs instead of time-lags for velocity estimate. As a reminder, the conventional DSO is an image-domain method for wave-equation tomography, where the essence of this method is to focus the image at zero suboffset and minimize the image at nonzero suboffset. At each iteration, the velocity model is updated by smearing the image on the nonzero sub- offset along wavepath. The space-lag is used as a penalty operator which annihilates the image energy at nonzero lags, where this space-lag is independent of the velocity model. This new method, denoted as generalized DSO, treats the space-lag as a function of velocity model. It is an extension of the conventional DSO except it updates the velocity model not only by smearing the image on the nonzero suboffset as in conventional DSO but also by smearing the nonzero suboffset along the wavepath. The former minimizes the image in the nonzero suboffset and the latter minimizes the nonzero suboffset of the image. Both methods aim to focus the image energy at zero suboffset. The mathematical derivation and numerical examples are presented to demonstrate its effectiveness in velocity inversion.

  3. Natural generalized mirage mediation

    Science.gov (United States)

    Baer, Howard; Barger, Vernon; Serce, Hasan; Tata, Xerxes

    2016-12-01

    In the supersymmetric scenario known as mirage mediation (MM), the soft supersymmetry (SUSY) breaking terms receive comparable anomaly-mediation and moduli-mediation contributions leading to the phenomenon of mirage unification. The simplest MM SUSY breaking models which are consistent with the measured Higgs mass and sparticle mass constraints are strongly disfavored by fine-tuning considerations. However, while MM makes robust predictions for gaugino masses, the scalar sector is quite sensitive to specific mechanisms for moduli stabilization and potential uplifting. We suggest here a broader setup of generalized mirage mediation (GMM), where heretofore discrete parameters are allowed as continuous to better parametrize these other schemes. We find that natural SUSY spectra consistent with both the measured value of mh as well as LHC lower bounds on superpartner masses are then possible. We explicitly show that models generated from natural GMM may be beyond the reach of even high-luminosity LHC searches. In such a case, the proposed International Linear e+e- Collider will be required for natural SUSY discovery via higgsino pair production reactions. We also outline prospects for detection of higgsino-like WIMPs from natural GMM.

  4. On a Generalized Hankel Type Convolution of Generalized Functions

    Indian Academy of Sciences (India)

    S P Malgonde; G S Gaikawad

    2001-11-01

    The classical generalized Hankel type convolution are defined and extended to a class of generalized functions. Algebraic properties of the convolution are explained and the existence and significance of an identity element are discussed.

  5. Action Principle for the Generalized Harmonic Formulation of General Relativity

    CERN Document Server

    Brown, J David

    2010-01-01

    An action principle for the generalized harmonic formulation of general relativity is presented. The action is a functional of the spacetime metric and the gauge source vector. The Z4 formulation of general relativity also can be defined by an action principle, as discussed by Bona, Bona--Casas and Palenzuela. The relationship between the generalized harmonic and Z4 actions is presented in detail.

  6. Generalization of stochastic visuomotor rotations.

    Directory of Open Access Journals (Sweden)

    Hugo L Fernandes

    Full Text Available Generalization studies examine the influence of perturbations imposed on one movement onto other movements. The strength of generalization is traditionally interpreted as a reflection of the similarity of the underlying neural representations. Uncertainty fundamentally affects both sensory integration and learning and is at the heart of many theories of neural representation. However, little is known about how uncertainty, resulting from variability in the environment, affects generalization curves. Here we extend standard movement generalization experiments to ask how uncertainty affects the generalization of visuomotor rotations. We find that although uncertainty affects how fast subjects learn, the perturbation generalizes independently of uncertainty.

  7. Generalized gap functions and error bounds for generalized variational inequalities

    Institute of Scientific and Technical Information of China (English)

    Yan-hong HU; Wen SONG

    2009-01-01

    We consider some classes of generalized gap functions for two kinds of gen-eralized variational inequality problems. We obtain error bounds for the underlying vari-ational inequalities using the generalized gap functions under the condition that the in-volved mapping F is g-strongly monotone with respect to the solution, but not necessarily continuous differentiable, even not locally Lipschitz.

  8. [Manual therapy in general practice].

    Science.gov (United States)

    Березуцкий, Владимир И

    2016-01-01

    The article is devoted to manual therapy practice for diagnostics and treatment of vertebrogenic pain syndrome in general practice. Analytical roundup of sources proves medical advantage of implementation of manual therapy basic methods by general practice specialists.

  9. Generalized gravity from modified DFT

    CERN Document Server

    Sakatani, Yuho; Yoshida, Kentaroh

    2016-01-01

    Recently, generalized equations of type IIB supergravity have been derived from the requirement of classical kappa-symmetry of type IIB superstring theory in the Green-Schwarz formulation. These equations are covariant under generalized T-duality transformations and hence one may expect a formulation similar to double field theory (DFT). In this paper, we consider a modification of the DFT equations of motion by relaxing a condition for the generalized covariant derivative with an extra generalized vector. In this modified double field theory (mDFT), we show that the flatness condition of the modified generalized Ricci tensor leads to the NS-NS part of the generalized equations of type IIB supergravity. In particular, the extra vector fields appearing in the generalized equations correspond to the extra generalized vector in mDFT. We also discuss duality symmetries and a modification of the string charge in mDFT.

  10. On the generalized lifting problem

    Directory of Open Access Journals (Sweden)

    Giorgio Bolondi

    1993-05-01

    Full Text Available We construct curves for which the generalized lifting property does not hold, with high degree. We discuss the behaviour of the Hilbert function of the general plane section of these curves.

  11. OLEDS FOR GENERAL LIGHTING

    Energy Technology Data Exchange (ETDEWEB)

    Anil Duggal; Don Foust; Chris Heller; Bill Nealon; Larry Turner; Joe Shiang; Nick Baynes; Tim Butler; Nalin Patel

    2004-02-29

    The goal of this program was to reduce the long term technical risks that were keeping the lighting industry from embracing and developing organic light-emitting diode (OLED) technology for general illumination. The specific goal was to develop OLEDs for lighting to the point where it was possible to demonstrate a large area white light panel with brightness and light quality comparable to a fluorescence source and with an efficacy comparable to that of an incandescent source. it was recognized that achieving this would require significant advances in three area: (1) the improvement of white light quality for illumination, (2) the improvement of OLED energy efficiency at high brightness, and (3) the development of cost-effective large area fabrication techniques. The program was organized such that, each year, a ''deliverable'' device would be fabricated which demonstrated progress in one or more of the three critical research areas. In the first year (2001), effort concentrated on developing an OLED capable of generating high illumination-quality white light. Ultimately, a down-conversion method where a blue OLED was coupled with various down-conversion layers was chosen. Various color and scattering models were developed to aid in material development and device optimization. The first year utilized this approach to deliver a 1 inch x 1 inch OLED with higher illumination-quality than available fluorescent sources. A picture of this device is shown and performance metrics are listed. To their knowledge, this was the first demonstration of true illumination-quality light from an OLED. During the second year, effort concentrated on developing a scalable approach to large area devices. A novel device architecture consisting of dividing the device area into smaller elements that are monolithically connected in series was developed. In the course of this development, it was realized that, in addition to being scalable, this approach made the device

  12. Methodological practicalities in analytical generalization

    DEFF Research Database (Denmark)

    Halkier, Bente

    2011-01-01

    In this article, I argue that the existing literature on qualitative methodologies tend to discuss analytical generalization at a relatively abstract and general theoretical level. It is, however, not particularly straightforward to “translate” such abstract epistemological principles into more...... operative methodological strategies for producing analytical generalizations in research practices. Thus, the aim of the article is to contribute to the discussions among qualitatively working researchers about generalizing by way of exemplifying some of the methodological practicalities in analytical...... and processes in producing the three different ways of generalizing: ideal typologizing, category zooming, and positioning....

  13. Genesis of general relativity - Discovery of general relativity

    OpenAIRE

    Weinstein, Galina

    2012-01-01

    The intermediate stage of the development of general relativity is inseparable of Marcel Grossmann's mathematical assistance. Einstein acknowledges Grossmann's help during 1912-1914 to the development of general relativity. In fact, as with special relativity so was it with General relativity, Einstein received assistance only from his old friends, Marcel Grossmann and Michele Besso. However, he continued to consider Besso as his eternal "sounding board"...

  14. The use of generalized functions and distributions in general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Steinbauer, R [Department of Mathematics, University of Vienna, Nordbergstrasse 15, A-1090 Wien (Austria); Vickers, J A [School of Mathematics, University of Southampton, Southampton SO17 1BJ (United Kingdom)

    2006-05-21

    We review the extent to which one can use classical distribution theory in describing solutions of Einstein's equations. We show that there are a number of physically interesting cases which cannot be treated using distribution theory but require a more general concept. We describe a mathematical theory of nonlinear generalized functions based on Colombeau algebras and show how this may be applied in general relativity. We end by discussing the concept of singularity in general relativity and show that certain solutions with weak singularities may be regarded as distributional solutions of Einstein's equations. (topical review)

  15. Conditioned Fear Acquisition and Generalization in Generalized Anxiety Disorder.

    Science.gov (United States)

    Tinoco-González, Daniella; Fullana, Miquel Angel; Torrents-Rodas, David; Bonillo, Albert; Vervliet, Bram; Blasco, María Jesús; Farré, Magí; Torrubia, Rafael

    2015-09-01

    Abnormal fear conditioning processes (including fear acquisition and conditioned fear-generalization) have been implicated in the pathogenesis of anxiety disorders. Previous research has shown that individuals with panic disorder present enhanced conditioned fear-generalization in comparison to healthy controls. Enhanced conditioned fear-generalization could also characterize generalized anxiety disorder (GAD), but research so far is inconclusive. An important confounding factor in previous research is comorbidity. The present study examined conditioned fear-acquisition and fear-generalization in 28 patients with GAD and 30 healthy controls using a recently developed fear acquisition and generalization paradigm assessing fear-potentiated startle and online expectancies of the unconditioned stimulus. Analyses focused on GAD patients without comorbidity but included also patients with comorbid anxiety disorders. Patients and controls did not differ as regards fear acquisition. However, contrary to our hypothesis, both groups did not differ either in most indexes of conditioned fear-generalization. Moreover, dimensional measures of GAD symptoms were not correlated with conditioned fear-generalization indexes. Comorbidity did not have a significant impact on the results. Our data suggest that conditioned fear-generalization is not enhanced in GAD. Results are discussed with special attention to the possible effects of comorbidity on fear learning abnormalities.

  16. Topics on nonlinear generalized functions

    CERN Document Server

    Colombeau, J F

    2011-01-01

    The aim of this paper is to give the text of a recent introduction to nonlinear generalized functions exposed in my talk in the congress gf2011, which was asked by several participants. Three representative topics were presented: two recalls "Nonlinear generalized functions and their connections with distribution theory", "Examples of applications", and a recent development: "Locally convex topologies and compactness: a functional analysis of nonlinear generalized functions".

  17. General form of quantum evolution

    CERN Document Server

    Chruscinski, Dariusz

    2010-01-01

    We propose a complete treatment of a local in time dynamics of open quantum systems. In this approach Markovian evolution turns out to be a special case of a general non-Markovian one. We provide a general representation of the local generator which generalizes well known Lindblad representation for the Markovian dynamics. It shows that the structure of non-Markovian generators is highly intricate and the problem of their classification is still open. Simple examples illustrate our approach.

  18. The generalized Airy diffusion equation

    Directory of Open Access Journals (Sweden)

    Frank M. Cholewinski

    2003-08-01

    Full Text Available Solutions of a generalized Airy diffusion equation and an associated nonlinear partial differential equation are obtained. Trigonometric type functions are derived for a third order generalized radial Euler type operator. An associated complex variable theory and generalized Cauchy-Euler equations are obtained. Further, it is shown that the Airy expansions can be mapped onto the Bessel Calculus of Bochner, Cholewinski and Haimo.

  19. Extended New Generalized Lindley Distribution

    Directory of Open Access Journals (Sweden)

    D. S. Shibu

    2016-03-01

    Full Text Available In this paper, we consider an extended version of new generalized Lindley distribution (NGLD. We refer to this new generalization as the extended new generalized Lindley distribution (ENGLD. A comprehensive account of the mathematical properties of the new distribution including estimation is presented. A real life data set is considered here to illustrate the relevance of the new model and compared it with other forms of Lindley models using method of moment estimation and method of maximum likelihood estimation.

  20. Introduction to the general relativity; Introduction a la relativite generale

    Energy Technology Data Exchange (ETDEWEB)

    Radix, J.C.

    1994-12-31

    This work deals with the introduction of the general relativity including the introduction of the tensorial calculation, the Euclidean space in curvilinear coordinates, the Riemann space, the recalls and complements of the restricted relativity and the elements of the general relativity. (O.L.) 83 figs., 3 tabs.

  1. Dynamics of generalized tachyon field

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Rongjia [Hebei University, College of Physical Science and Technology, Baoding (China); Tsinghua University, Department of Physics, Beijing (China); Qi, Jingzhao [Hebei University, College of Physical Science and Technology, Baoding (China)

    2012-08-15

    We investigate the dynamics of generalized tachyon field in FRW spacetime. We obtain the autonomous dynamical system for the general case. Because the general autonomous dynamical system cannot be solved analytically, we discuss two cases in detail: {beta}=1 and {beta}=2. We find the critical points and study their stability. At these critical points, we also consider the stability of the generalized tachyon field, which is as important as the stability of critical points. The possible final states of the universe are discussed. (orig.)

  2. Using "Informances" in General Music

    Science.gov (United States)

    Zaffini, Erin Dineen

    2015-01-01

    General music teachers might be faced with formal performance expectations placed on them by administrators. While performance expectations are common in performance-based ensembles, meeting these expectations can be cumbersome and daunting to those who serve in the realm of general music. Informances--informative presentations of student learning…

  3. Hyperbolic Formulation of General Relativity

    CERN Document Server

    Abrahams, A M; Choquet-Bruhat, Y; York, J W; Abrahams, Andrew; Anderson, Arlen; Choquet-Bruhat, Yvonne; York, James W.

    1998-01-01

    Two geometrical well-posed hyperbolic formulations of general relativity are described. One admits any time-slicing which preserves a generalized harmonic condition. The other admits arbitrary time-slicings. Both systems have only the physical characteristic speeds of zero and the speed of light.

  4. Using "Informances" in General Music

    Science.gov (United States)

    Zaffini, Erin Dineen

    2015-01-01

    General music teachers might be faced with formal performance expectations placed on them by administrators. While performance expectations are common in performance-based ensembles, meeting these expectations can be cumbersome and daunting to those who serve in the realm of general music. Informances--informative presentations of student learning…

  5. 100 Years of General Relativity

    CERN Document Server

    Ellis, George F R

    2015-01-01

    This is Chapter 1 in the book General Relativity and Gravitation: A Centennial Perspective, Edited by Abhay Ashtekar (Editor in Chief), Beverly Berger, James Isenberg, Malcolm MacCallum. Publisher: Cambridge University Press (June, 2015). It gives a survey of themes that have been developed during the 100 years of progress in general relativity theory.

  6. Behavioural science in general practice.

    Science.gov (United States)

    Wood, D R

    1979-10-01

    Dr Peter Sowerby has written an important criticism of Michael Balint's work based on his understanding of Karl Popper's writings. I dispute Sowerby's interpretation of Popper and disagree with his conclusions, which I suggest would lead general practice into a retreat. I believe Balint made a major contribution to general practice and has helped us towards practising whole-person medicine.

  7. Personality, Intelligence and General Knowledge

    Science.gov (United States)

    Furnham, Adrian; Chamorro-Premuzic, Tomas

    2006-01-01

    Three studies, all on student populations, looked at the relationship between a recently psychometrised measure of General Knowledge [Irwing, P., Cammock, T., & Lynn, R. (2001). Some evidence for the existence of a general factor of semantic memory and its components. "Personality and Individual Differences," 30, 857-871], both long…

  8. Generalized functionals of Brownian motion

    Directory of Open Access Journals (Sweden)

    N. U. Ahmed

    1994-01-01

    Full Text Available In this paper we discuss some recent developments in the theory of generalized functionals of Brownian motion. First we give a brief summary of the Wiener-Ito multiple Integrals. We discuss some of their basic properties, and related functional analysis on Wiener measure space. then we discuss the generalized functionals constructed by Hida. The generalized functionals of Hida are based on L2-Sobolev spaces, thereby, admitting only Hs, s∈R valued kernels in the multiple stochastic integrals. These functionals are much more general than the classical Wiener-Ito class. The more recent development, due to the author, introduces a much more broad class of generalized functionals which are based on Lp-Sobolev spaces admitting kernels from the spaces p,s, s∈R. This allows analysis of a very broad class of nonlinear functionals of Brownian motion, which can not be handled by either the Wiener-Ito class or the Hida class. For s≤0, they represent generalized functionals on the Wiener measure space like Schwarz distributions on finite dimensional spaces. In this paper we also introduce some further generalizations, and construct a locally convex topological vector space of generalized functionals. We also present some discussion on the applications of these results.

  9. Sampling Assumptions in Inductive Generalization

    Science.gov (United States)

    Navarro, Daniel J.; Dry, Matthew J.; Lee, Michael D.

    2012-01-01

    Inductive generalization, where people go beyond the data provided, is a basic cognitive capability, and it underpins theoretical accounts of learning, categorization, and decision making. To complete the inductive leap needed for generalization, people must make a key "sampling" assumption about how the available data were generated.…

  10. 14 CFR Section 8 - General

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false General Section 8 Section 8 Aeronautics and... Section 8 General (a) The profit and loss accounts are designed to reflect, through natural groupings, the... activities, are set forth in section 7, Chart of Profit and Loss Accounts. (d) The prescribed system of...

  11. 14 CFR Section 4 - General

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false General Section 4 Section 4 Aeronautics and... Section 4 General (a) The balance sheet accounts are designed to show the financial condition of the air... prescribed in this system of accounts for each air carrier group are set forth in Section 3, Chart of Balance...

  12. Prescription in Dutch general practice.

    NARCIS (Netherlands)

    Dijk, L. van

    2006-01-01

    The second Dutch National Survey of General Practice (DNSGP-2) has combined registration data on morbidity and prescription, making it possible to unravel diagnosis-specific prescription behaviour of general practitioners(GPs). Prescription rates for different disorders vary considerably, especially

  13. Cosmological structures in generalized gravity

    CERN Document Server

    Hwang, J

    1997-01-01

    In a class of generalized gravity theories with general couplings between the scalar field and the scalar curvature in the Lagrangian, we describe the quantum generation and the classical evolution processes of both the scalar and tensor structures in a simple and unified manner.

  14. Spontaneously induced general relativity with holographic interior and general exterior

    CERN Document Server

    Shen, Xiao-Qing; Yang, Guo-Hong

    2012-01-01

    The general relativity (GR) might be viewed as a spontaneously induced theory from the scalar-tensor gravity, in which the would-have-been horizon connects the exterior solution of GR with a novel core of vanishing spatial volume. Using a simple but robust analytic method, we give the nontrivial core metric for the general exterior. Then we show that all the nontrivial features of the core, including the locally holographic entropy packing, are not influenced by the general exterior. We also investigate whether other modified theories of gravity can permit the nontrivial core.

  15. GENERALIZED DERIVATIONS ON PARABOLIC SUBALGEBRAS OF GENERAL LINEAR LIE ALGEBRAS

    Institute of Scientific and Technical Information of China (English)

    陈正新

    2014-01-01

    Let P be a parabolic subalgebra of a general linear Lie algebra gl(n, F) over a field F, where n ≥ 3, F contains at least n different elements, and char(F) 6= 2. In this article, we prove that generalized derivations, quasiderivations, and product zero derivations of P coincide, and any generalized derivation of P is a sum of an inner derivation, a central quasiderivation, and a scalar multiplication map of P. We also show that any commuting automorphism of P is a central automorphism, and any commuting derivation of P is a central derivation.

  16. Generalized functions, volume 2 spaces of fundamental and generalized functions

    CERN Document Server

    Gel′fand, I M

    2016-01-01

    The first systematic theory of generalized functions (also known as distributions) was created in the early 1950s, although some aspects were developed much earlier, most notably in the definition of the Green's function in mathematics and in the work of Paul Dirac on quantum electrodynamics in physics. The six-volume collection, Generalized Functions, written by I. M. Gel′fand and co-authors and published in Russian between 1958 and 1966, gives an introduction to generalized functions and presents various applications to analysis, PDE, stochastic processes, and representation theory. Volume 2

  17. General relativity and mathematics; Relatividad General y Matematicas

    Energy Technology Data Exchange (ETDEWEB)

    Mars, M.

    2015-07-01

    General relativity is more than a theory of gravity, since any physical process occupies space and lasts for a time, forcing to reconcile that physical theory that describes what the dynamic nature of space-time itself. (Author)

  18. Generalized Cole–Hopf transformations for generalized Burgers equations

    Indian Academy of Sciences (India)

    B Mayil Vaganan; E Emily Priya

    2015-11-01

    A detailed review of the invention of Cole–Hopf transformations for the Burgers equation and all the subsequent works which include generalizations of the Burgers equation and the corresponding developments in Cole–Hopf transformations are documented.

  19. 2008 Contruction General Permits & Multi-Sector General Permits

    Data.gov (United States)

    U.S. Environmental Protection Agency — View stormwater notices of intent (NOIs) for construction projects under EPA's 2008 Construction General Permit (CGP), for Low Erosivity Waivers (LEWs) submitted...

  20. Generalized complex geometry, generalized branes and the Hitchin sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Zucchini, Roberto E-mail: zucchinir@bo.infn.it

    2005-03-01

    Hitchin's generalized complex geometry has been shown to be relevant in compactifications of superstring theory with fluxes and is expected to lead to a deeper understanding of mirror symmetry. Gualtieri's notion of generalized complex submanifold seems to be a natural candidate for the description of branes in this context. Recently, we introduced a Batalin-Vilkovisky field theoretic realization of generalized complex geometry, the Hitchin sigma model, extending the well known Poisson sigma model. In this paper, exploiting Gualtieri's formalism, we incorporate branes into the model. A detailed study of the boundary conditions obeyed by the world sheet fields is provided. Finally, it is found that, when branes are present, the classical Batalin-Vilkovisky cohomology contains an extra sector that is related non trivially to a novel cohomology associated with the branes as generalized complex submanifolds. (author)

  1. Generalized complex geometry, generalized branes and the Hitchin sigma model

    CERN Document Server

    Zucchini, R

    2005-01-01

    Hitchin's generalized complex geometry has been shown to be relevant in compactifications of superstring theory with fluxes and is expected to lead to a deeper understanding of mirror symmetry. Gualtieri's notion of generalized complex submanifold seems to be a natural candidate for the description of branes in this context. Recently, we introduced a field theoretic realization of generalized complex geometry, the Hitchin sigma model, extending the well known Poisson sigma model. In this paper, exploiting Gualtieri's formalism, we incorporate branes into the model. A detailed study of the boundary conditions obeyed by the world sheet fields is provided. Finally, it is found that, when branes are present, the classical Batalin--Vilkovisky cohomology contains an extra sector that is related non trivially to a novel cohomology associated with the branes as generalized complex submanifolds.

  2. General base-general acid catalysis by terpenoid cyclases.

    Science.gov (United States)

    Pemberton, Travis A; Christianson, David W

    2016-07-01

    Terpenoid cyclases catalyze the most complex reactions in biology, in that more than half of the substrate carbon atoms often undergo changes in bonding during the course of a multistep cyclization cascade that proceeds through multiple carbocation intermediates. Many cyclization mechanisms require stereospecific deprotonation and reprotonation steps, and most cyclization cascades are terminated by deprotonation to yield an olefin product. The first bacterial terpenoid cyclase to yield a crystal structure was pentalenene synthase from Streptomyces exfoliatus UC5319. This cyclase generates the hydrocarbon precursor of the pentalenolactone family of antibiotics. The structures of pentalenene synthase and other terpenoid cyclases reveal predominantly nonpolar active sites typically lacking amino acid side chains capable of serving general base-general acid functions. What chemical species, then, enables the Brønsted acid-base chemistry required in the catalytic mechanisms of these enzymes? The most likely candidate for such general base-general acid chemistry is the co-product inorganic pyrophosphate. Here, we briefly review biological and nonbiological systems in which phosphate and its derivatives serve general base and general acid functions in catalysis. These examples highlight the fact that the Brønsted acid-base activities of phosphate derivatives are comparable to the Brønsted acid-base activities of amino acid side chains.

  3. The evolution of general intelligence.

    Science.gov (United States)

    Burkart, Judith M; Schubiger, Michèle N; van Schaik, Carel P

    2016-07-28

    The presence of general intelligence poses a major evolutionary puzzle, which has led to increased interest in its presence in nonhuman animals. The aim of this review is to critically evaluate this puzzle, and to explore the implications for current theories about the evolution of cognition. We first review domain-general and domain-specific accounts of human cognition in order to situate attempts to identify general intelligence in nonhuman animals. Recent studies are consistent with the presence of general intelligence in mammals (rodents and primates). However, the interpretation of a psychometric g-factor as general intelligence needs to be validated, in particular in primates, and we propose a range of such tests. We then evaluate the implications of general intelligence in nonhuman animals for current theories about its evolution and find support for the cultural intelligence approach, which stresses the critical importance of social inputs during the ontogenetic construction of survival-relevant skills. The presence of general intelligence in nonhumans implies that modular abilities can arise in two ways, primarily through automatic development with fixed content and secondarily through learning and automatization with more variable content. The currently best-supported model, for humans and nonhuman vertebrates alike, thus construes the mind as a mix of skills based on primary and secondary modules. The relative importance of these two components is expected to vary widely among species, and we formulate tests to quantify their strength.

  4. Categorical Generalization and Physical Structuralism

    CERN Document Server

    Lal, Raymond

    2014-01-01

    Category theory has become central to certain aspects of theoretical physics. Bain [Synthese, 190:1621--1635 (2013)] has recently argued that this has significance for ontic structural realism. We argue against this claim. In so doing, we uncover two pervasive forms of category-theoretic generalization. We call these `generalization by duality' and `generalization by categorifying physical processes'. We describe in detail how these arise, and explain their significance using detailed examples. We show that their significance is two-fold: the articulation of high-level physical concepts, and the generation of new models.

  5. Generalization of Hopf Functional Equation

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper generalizes the Hopf functional equation in order to apply it to a wider class of not necessarily incompressible fluid flows. We start by defining characteristic functionals of the velocity field, the density field and the temperature field of a compressible field. Using the continuity equation, the Navier-Stokes equations and the equation of energy we derive a functional equation governing the motion of an ideal gas flow and a van der Waals gas flow, and then give some general methods of deriving a functional equation governing the motion of any compressible fluid flow. These functional equations can be considered as the generalization of the Hopf functional equation.

  6. Remarks on generalized Fedosov algebras

    CERN Document Server

    Dobrski, Michal

    2014-01-01

    The variant of Fedosov construction based on fairly general fiberwise product in the Weyl bundle is studied. Here, we analyze generalized star products of functions, of sections of endomorphisms bundle, and those generating deformed bimodule structure as introduced previously by Waldmann. Isomorphisms of generalized Fedosov algebras are considered and their relevance for deriving Seiberg-Witten map is described. The existence of the trace functional is established. For star products and for the trace functional explicit expressions, up to second power of deformation parameter, are given. As an example, we discuss the case of symmetric part of non-commutativity tensor.

  7. A generalized advection dispersion equation

    Indian Academy of Sciences (India)

    Abdon Atangana

    2014-02-01

    This paper examines a possible effect of uncertainties, variability or heterogeneity of any dynamic system when being included in its evolution rule; the notion is illustrated with the advection dispersion equation, which describes the groundwater pollution model. An uncertain derivative is defined; some properties of the operator are presented. The operator is used to generalize the advection dispersion equation. The generalized equation differs from the standard equation in four properties. The generalized equation is solved via the variational iteration technique. Some illustrative figures are presented.

  8. Acute Paraplegia After General Anesthesia

    Directory of Open Access Journals (Sweden)

    Gholam Hossein Ghaedi

    2011-08-01

    Full Text Available Acute paraplegia is a rare but catastrophic complication of surgeries performed on aorta and corrective operations of vertebral column. Trauma to spinal cord after spinal anesthesia and ischemia of spinal cord also may lead to acute paraplegia. Acute paraplegia as a complication of general anesthesia in surgeries performed on sites other than aorta and vertebral column is very rare. Here we present a 56 year old woman with acute paraplegia due to spinal cord infarction after laparoscopic cholecystectomy under general anesthesia probably caused by atherosclerosis of feeding spinal arteries and ischemia of spinal cord after reduction of blood flow possibly due to hypotension during general anesthesia.

  9. Generalized $r$-Lah numbers

    Indian Academy of Sciences (India)

    MARK SHATTUCK

    2016-10-01

    In this paper, we consider a two-parameter polynomial generalization, denoted by ${\\mathcal G}_{a,b}(n, k; r)$, of the $r$-Lah numbers which reduces to these recently introduced numbers when $a = b = 1$. We present several identities for ${\\mathcal G}_{a,b}(n, k; r)$ that generalize earlier identities given for the $r$-Lah and $r$-Stirling numbers. We also provide combinatorial proofs of some earlier identities involving the $r$-Lah numbers by defining appropriate sign-changing involutions. Generalizing these arguments yields orthogonality-type relations that are satisfied by ${\\mathcal G}_{a,b}(n, k; r)$.

  10. Anisotropic Inflation with General Potentials

    CERN Document Server

    Shi, Jiaming; Qiu, Taotao

    2015-01-01

    Anomalies in recent observational data indicate that there might be some "anisotropic hair" generated in an inflation period. To obtain general information about the effects of this anisotropic hair to inflation models, we studied anisotropic inflation models that involve one vector and one scalar using several types of potentials. We determined the general relationship between the degree of anisotropy and the fraction of the vector and scalar fields, and concluded that the anisotropies behave independently of the potentials. We also generalized our study to the case of multi-directional anisotropies.

  11. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis.

    Science.gov (United States)

    Six, Robert H; Becskei, Csilla; Mazaleski, Mark M; Fourie, Josephus J; Mahabir, Sean P; Myers, Melanie R; Slootmans, Nathalie

    2016-05-30

    The efficacy of sarolaner (Simparica™, Zoetis) was evaluated against Demodex spp. in dogs with generalized demodicosis and against Otodectes cynotis (otodectic mange) in dogs with induced infestations. In the first study, 16 dogs with clinical signs of generalized demodicosis and positive for Demodex spp. mites were randomly assigned to treatment with either sarolaner (2mg/kg) orally on Days 0, 30 and 60, or topical imidacloprid (10mg/kg) plus moxidectin (2.5mg/kg) solution every 7 days from Day 0 to Day 81. For sarolaner-treated dogs, pretreatment mite counts were reduced by 97.1% at 14days and 99.8% by 29 days after the first dose, with no live mites detected thereafter. Weekly imidacloprid plus moxidectin resulted in 84.4 and 95.6% reduction at these two time points, respectively, with no mites detected from Day 74 on. All dogs in both groups showed marked improvement in the clinical signs of demodicosis. In the second study, 32 dogs with induced infestations of O. cynotis were randomly assigned (eight per group) to oral sarolaner (2mg/kg) as a single treatment on Day 0 or as a two dose regime (Days 0 and 30), or a placebo group for each of the dose regimes. Sarolaner administered at 2mg/kg as a single oral dose resulted in a 98.2% reduction at Day 30 and two doses of sarolaner, administered one month apart, resulted in a 99.5% reduction in ear mites at Day 60 compared to placebo controls. There were no treatment related adverse events in either study. In these studies, sarolaner at an oral dose of 2mg/kg was highly effective in reducing the live mite counts associated with a natural infestation of Demodex spp. and an induced infestation of O. cynotis. In addition, the Demodex-infested dogs showed a marked improvement in the clinical signs of generalized demodicosis.

  12. Exact solution for generalized pairing

    OpenAIRE

    Pan, Feng; J.P. Draayer

    1997-01-01

    An infinite dimensional algebra, which is useful for deriving exact solutions of the generalized pairing problem, is introduced. A formalism for diagonalizing the corresponding Hamiltonian is also proposed. The theory is illustrated with some numerical examples.

  13. On Generalized Vector Equilibrium Problems

    Institute of Scientific and Technical Information of China (English)

    An-hua Wan; Jun-yi Fu; Wei-hua Mao

    2006-01-01

    A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi-concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of the solution sets are established.

  14. The future of general medicine.

    Science.gov (United States)

    Firth, John

    2014-08-01

    It is a truth universally acknowledged that there is a problem with general medicine. Physicians have become increasingly specialised over the past 30 years or so, and specialist care has produced increasingly better outcomes for some patients. The patients left behind are looked after by general medicine, where demand is increasing, operational priority within hospitals is low, there is little professional kudos and recruitment is suffering. Three recent reports - Hospitals on the Edge?, the Future Hospital Commission report, and the Shape of Training report - have described the problems, but not articulated compelling solutions. Here, I discuss what is good about general medicine, what is bad and make suggestions for improvement. These involve getting specialities to take responsibility for care of appropriate admissions automatically and without delay, giving general physicians control over the service that they provide, and using well-chosen financial drivers to support movement in the right direction.

  15. Generalized Wellposedness and Multivalued Contraction

    OpenAIRE

    PRABACKAR, Arockia; UTHAYAKUMAR, Ramasamy

    2014-01-01

    In this paper, we establish the fixed point theorem for multivalued contraction. Also we prove that the generalized well posedness of the fixed point problem and continuity of multivalued contraction. 

  16. General ideas on English reading

    Institute of Scientific and Technical Information of China (English)

    祝文瑛

    2015-01-01

    This paper is talking about some general ideas on English reading in order to help teachers and learners foster some reading skills by seeing through its natures aiming at effective and productive English teaching and learning.

  17. General Information about Colon Cancer

    Science.gov (United States)

    ... Genetics of Colorectal Cancer Colorectal Cancer Screening Research Colon Cancer Treatment (PDQ®)–Patient Version General Information About Colon Cancer Go to Health Professional Version Key Points Colon ...

  18. Categorical database generalization in GIS

    NARCIS (Netherlands)

    Liu, Y.

    2002-01-01

    Key words: Categorical database, categorical database generalization, Formal data structure, constraints, transformation unit, classification hierarchy, aggregation hierarchy, semantic similarity, data model, Delaunay triangulation

  19. Generalized Heisenberg theory of turbulence

    Science.gov (United States)

    Uberoi, M. S.; Narain, J. P.

    1974-01-01

    Solutions of the generalized theory are obtained which are consistent with the previous work on energy transfer measurements. They also agree with the measurements of turbulent energy spectrum for wave numbers in the universal equilibrium range.

  20. Work Ethics and General Morality

    Institute of Scientific and Technical Information of China (English)

    赵玲玲

    2016-01-01

    "The Starving Sudan" is a photographic work awarded with South Africa Pulitzer Prize, which also arouses the warm discussion about work ethics and general morality. This paper aims to give comments from an objective perspective.

  1. General correcting formula of forecasting?

    OpenAIRE

    2009-01-01

    A general correcting formula of forecasting (as a framework for long-use and standardized forecasts) is proposed. The formula provides new forecasting resources and areas of application including economic forecasting.

  2. General Information about Pituitary Tumors

    Science.gov (United States)

    ... Tumors Treatment Pituitary Tumors Treatment (PDQ®)–Patient Version General Information About Pituitary Tumors Go to Health Professional ... by many other glands in the body. Enlarge Anatomy of the inside of the brain, showing the ...

  3. General Information About Endometrial Cancer

    Science.gov (United States)

    ... Screening Research Endometrial Cancer Treatment (PDQ®)–Patient Version General Information About Endometrial Cancer Go to Health Professional ... the cervix , which leads to the vagina . Enlarge Anatomy of the female reproductive system. The organs in ...

  4. General Information about Thyroid Cancer

    Science.gov (United States)

    ... Screening Research Thyroid Cancer Treatment (PDQ®)–Patient Version General Information About Thyroid Cancer Go to Health Professional ... usually cannot be felt through the skin. Enlarge Anatomy of the thyroid and parathyroid glands. The thyroid ...

  5. General Information about Prostate Cancer

    Science.gov (United States)

    ... Screening Research Prostate Cancer Treatment (PDQ®)–Patient Version General Information About Prostate Cancer Go to Health Professional ... fluid that is part of the semen . Enlarge Anatomy of the male reproductive and urinary systems, showing ...

  6. General Information about Penile Cancer

    Science.gov (United States)

    ... Cancer Treatment Penile Cancer Treatment (PDQ®)–Patient Version General Information About Penile Cancer Go to Health Professional ... covered with loose skin called the foreskin . Enlarge Anatomy of the penis. The parts of the penis ...

  7. General Information about Vulvar Cancer

    Science.gov (United States)

    ... Treatment Research Vulvar Cancer Treatment (PDQ®)–Patient Version General Information About Vulvar Cancer Go to Health Professional ... area between the vulva and the anus ). Enlarge Anatomy of the vulva. The vulva includes the mons ...

  8. General Information about Vaginal Cancer

    Science.gov (United States)

    ... Treatment Research Vaginal Cancer Treatment (PDQ®)–Patient Version General Information About Vaginal Cancer Go to Health Professional ... the vagina (also called the birth canal). Enlarge Anatomy of the female reproductive system. The organs in ...

  9. General Information about Breast Cancer

    Science.gov (United States)

    ... Screening Research Breast Cancer Treatment (PDQ®)–Patient Version General Information About Breast Cancer Go to Health Professional ... are linked by thin tubes called ducts. Enlarge Anatomy of the female breast. The nipple and areola ...

  10. General Information about Pancreatic Cancer

    Science.gov (United States)

    ... Treatment Research Pancreatic Cancer Treatment (PDQ®)–Patient Version General Information About Pancreatic Cancer Go to Health Professional ... lies between the stomach and the spine . Enlarge Anatomy of the pancreas. The pancreas has three areas: ...

  11. General Information about Urethral Cancer

    Science.gov (United States)

    ... Cancer Treatment Urethral Cancer Treatment (PDQ®)–Patient Version General Information About Urethral Cancer Go to Health Professional ... In men, the urethra also carries semen . Enlarge Anatomy of the male urinary system (left panel) and ...

  12. General covariance in computational electrodynamics

    DEFF Research Database (Denmark)

    Shyroki, Dzmitry; Lægsgaard, Jesper; Bang, Ole;

    2007-01-01

    We advocate the generally covariant formulation of Maxwell equations as underpinning some recent advances in computational electrodynamics—in the dimensionality reduction for separable structures; in mesh truncation for finite-difference computations; and in adaptive coordinate mapping as opposed...

  13. Generalized metric spaces and mappings

    CERN Document Server

    Lin, Shou

    2016-01-01

    The idea of mutual classification of spaces and mappings is one of the main research directions of point set topology. In a systematical way, this book discusses the basic theory of generalized metric spaces by using the mapping method, and summarizes the most important research achievements, particularly those from Chinese scholars, in the theory of spaces and mappings since the 1960s. This book has three chapters, two appendices and a list of more than 400 references. The chapters are "The origin of generalized metric spaces", "Mappings on metric spaces" and "Classes of generalized metric spaces". Graduates or senior undergraduates in mathematics major can use this book as their text to study the theory of generalized metric spaces. Researchers in this field can also use this book as a valuable reference.

  14. General correcting formula of forecasting?

    OpenAIRE

    Harin, Alexander

    2009-01-01

    A general correcting formula of forecasting (as a framework for long-use and standardized forecasts) is proposed. The formula provides new forecasting resources and areas of application including economic forecasting.

  15. The 'simple' general dental anaesthetic

    African Journals Online (AJOL)

    The patient who receives dental treatment under general anaesthesia is usually a child, one with special ... under various anaesthetic techniques and .... preoperatively in the presence of a parent or .... helpful in counteracting the stress caused.

  16. Problem Solving with General Semantics.

    Science.gov (United States)

    Hewson, David

    1996-01-01

    Discusses how to use general semantics formulations to improve problem solving at home or at work--methods come from the areas of artificial intelligence/computer science, engineering, operations research, and psychology. (PA)

  17. Generalized Entropy Concentration for Counts

    CERN Document Server

    Oikonomou, Kostas N

    2016-01-01

    We consider the phenomenon of entropy concentration under linear constraints in a discrete setting, using the "balls and bins" paradigm, but without the assumption that the number of balls allocated to the bins is known. Therefore instead of \\ frequency vectors and ordinary entropy, we have count vectors with unknown sum, and a certain generalized entropy. We show that if the constraints bound the allowable sums, this suffices for concentration to occur even in this setting. The concentration can be either in terms of deviation from the maximum generalized entropy value, or in terms of the norm of the difference from the maximum generalized entropy vector. Without any asymptotic considerations, we quantify the concentration in terms of various parameters, notably a tolerance on the constraints which ensures that they are always satisfied by an integral vector. Generalized entropy maximization is not only compatible with ordinary MaxEnt, but can also be considered an extension of it, as it allows us to address...

  18. The future of general classification

    DEFF Research Database (Denmark)

    Mai, Jens Erik

    2013-01-01

    Discusses problems related to accessing multiple collections using a single retrieval language. Surveys the concepts of interoperability and switching language. Finds that mapping between more indexing languages always will be an approximation. Surveys the issues related to general classification...... and contrasts that to special classifications. Argues for the use of general classifications to provide access to collections nationally and internationally. © 2003 by The Haworth Press, Inc. All rights reserved....

  19. A note on generalized pentagons

    DEFF Research Database (Denmark)

    Brandt, Stephan

    2010-01-01

    Thomassen introduced the notion of a generalized pentagon and proved that the chromatic number of a triangle-free graph with n vertices and minimum degree at least cn, c>13, is at most 2(3c-1)-(4c-1)(3c-1), the first bound independent of the order n. We present a short proof of the stronger upper...... bound (3c-1)-1, again based on generalized pentagons. © 2010 Elsevier B.V....

  20. Kaluza's theory in generalized coordinates

    CERN Document Server

    García-Perciante, A L; García-Colin, L S; Garcia-Perciante, Ana Laura; Sandoval-Villalbazo, Alfredo

    2001-01-01

    Maxwell's equations can be obtained in generalized coordinates by considering the electromagnetic field as an external agent. The work here presented shows how to obtain the electrodynamics for a charged particle in generalized coordinates eliminating the concept of external force. Based on Kaluza's formalism, the one here presented extends the 5x5 metric into a 6x6 space-time giving enough room to include magnetic monopoles in a very natural way.

  1. The elderly and general anesthesia

    DEFF Research Database (Denmark)

    Steinmetz, J; Rasmussen, L S

    2010-01-01

    Due to the aging population, the number of elderly patients taking advantage of healthcare services is increasing. A general physical decline of all organ systems and a high frequency of chronic disease accompanying aging.Comorbidity and polypharmacy are therefore common in the elderly. Hence, th......, the administration of general anesthesia to the elderly can be a very challenging task. This paper aims to highlight some of the important issues presented to the elderly undergoing surgery and to suggest some strategies for management....

  2. Transform analysis of generalized functions

    CERN Document Server

    Misra, O P

    1986-01-01

    Transform Analysis of Generalized Functions concentrates on finite parts of integrals, generalized functions and distributions. It gives a unified treatment of the distributional setting with transform analysis, i.e. Fourier, Laplace, Stieltjes, Mellin, Hankel and Bessel Series.Included are accounts of applications of the theory of integral transforms in a distributional setting to the solution of problems arising in mathematical physics. Information on distributional solutions of differential, partial differential equations and integral equations is conveniently collected here.The volume will

  3. A generalized gyrokinetic Poisson solver

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Z.; Lee, W.W.

    1995-03-01

    A generalized gyrokinetic Poisson solver has been developed, which employs local operations in the configuration space to compute the polarization density response. The new technique is based on the actual physical process of gyrophase-averaging. It is useful for nonlocal simulations using general geometry equilibrium. Since it utilizes local operations rather than the global ones such as FFT, the new method is most amenable to massively parallel algorithms.

  4. Generally representative is generally representative: comment on Shuttleworth-Edwards.

    Science.gov (United States)

    Taylor, Nicola

    2016-10-01

    The aim of this paper is to provide comment on Shuttleworth-Edwards' criticism of the general population norms created for the South African adaptation of the WAIS-IV. In her criticism, she states that the norms are not applicable for any groups in South Africa, based on the fact that the norms were not stratified according to quality of education. A discussion of some of the key issues that impact on the creation of general population norms in the South African context is provided. Demographic characteristics such as education level, quality of education, urban and rural demarcations, and home language are all considered. While the utility of within-group norms is not denied, the adoption of these without reference to the general population is not advised. To recommend that practitioners simply dispense with the general population norm without evidence that it creates misclassification or does not function effectively for the intended population lacks scientific merit at the current time. The need for clinical studies and further predictive validity research using the South African adaptation of the WAIS-IV is crucial to demonstrate the continued utility of the test in the South African context. Additional reference groups will improve the amount of comparative information available for clinicians to be able to make better informed decisions for diagnosis, but the general population norms will be an important starting point in this process.

  5. Perfil profesional del cirujano general: Professional profile General surgeon

    Directory of Open Access Journals (Sweden)

    José Antonio Hernández Varea

    2009-09-01

    Full Text Available El perfil del egresado es un elemento clave para confección del currículo, y constituye el modelo de las características, conocimientos y habilidades que se aspira formar en el futuro cirujano. Dicho perfil debe responder a las necesidades sociales, permitir la planificación del proceso docente-educativo y concretar la relación universidad-sociedad. En el presente artículo se analizan, a partir de la situación actual, los antecedentes históricos del modelo de formación del especialista en cirugía general, la definición de cirugía general, los principales cambios internacionales en el modelo de formación de cirujanos y las funciones generales que se deben considerar en el perfil profesional del cirujano y su cumplimiento en el programa de cirugía.Graduate profile is a key element to make the curriculum, and it is a representation of the possible features, knowledges, and abilities in the future surgeon. Such profile must to account for social needs, to allow the planning of teaching-educational process, and to stay exactly the university-society relation. In present paper, from a current situation, are analyzed the historical backgrounds of training model of general surgery specialist, general surgery definition, the main international changes in the training model of surgeon, and its fulfillment in surgery program.

  6. Monomelic amyotrophy with late progression.

    Science.gov (United States)

    Rowin, J; Meriggioli, M N; Cochran, E J

    2001-04-01

    Monomelic amyotrophy is a sporadic juvenile-onset disease that presents with gradual onset of weakness and atrophy in the hand muscles unilaterally. Generally, this disease is considered a 'benign' and non-progressive motor neuron disease, which stabilizes within five years of onset. We discuss a case that illustrates that monomelic amyotrophy may rarely exhibit late clinical progression to the lower extremities after a prolonged period of disease stability.

  7. Teachers' Understanding of Algebraic Generalization

    Science.gov (United States)

    Hawthorne, Casey Wayne

    Generalization has been identified as a cornerstone of algebraic thinking (e.g., Lee, 1996; Sfard, 1995) and is at the center of a rich conceptualization of K-8 algebra (Kaput, 2008; Smith, 2003). Moreover, mathematics teachers are being encouraged to use figural-pattern generalizing tasks as a basis of student-centered instruction, whereby teachers respond to and build upon the ideas that arise from students' explorations of these activities. Although more and more teachers are engaging their students in such generalizing tasks, little is known about teachers' understanding of generalization and their understanding of students' mathematical thinking in this domain. In this work, I addressed this gap, exploring the understanding of algebraic generalization of 4 exemplary 8th-grade teachers from multiple perspectives. A significant feature of this investigation is an examination of teachers' understanding of the generalization process, including the use of algebraic symbols. The research consisted of two phases. Phase I was an examination of the teachers' understandings of the underlying quantities and quantitative relationships represented by algebraic notation. In Phase II, I observed the instruction of 2 of these teachers. Using the lens of professional noticing of students' mathematical thinking, I explored the teachers' enacted knowledge of algebraic generalization, characterizing how it supported them to effectively respond to the needs and queries of their students. Results indicated that teachers predominantly see these figural patterns as enrichment activities, disconnected from course content. Furthermore, in my analysis, I identified conceptual difficulties teachers experienced when solving generalization tasks, in particular, connecting multiple symbolic representations with the quantities in the figures. Moreover, while the teachers strived to overcome the challenges of connecting different representations, they invoked both productive and unproductive

  8. THE ESSENCE OF GENERAL EDUCATION

    Directory of Open Access Journals (Sweden)

    Alexander A. Frolov

    2015-01-01

    Full Text Available The aim of the investigation is to disclosure essence, purpose and coherence of the system of general education through its subject content. Methods. The methods involve literature overview, theoretical research and observation. Combined application on the methodological level has provided a systematic approach to identifying the goals of general education and the structuring of its substantive content. Results. The development of students’ speculative powers should be the main task of general education whereby they can create individual model representation according to form but meaningfully adequate to the real life. The scheme of model representations development in the process of general education is proposed. Scientific novelty. The pedagogical model of development of educational process is proposed as the instrument of educational and social adaptation for students; the model represents a logical sequence of formation by students an adequate model of reality with increasing complexity. Practical significance. The proposed pedagogical model allows considering the process of general education mastery and development in absolute unity of its subject content, which should lead to the formation and development of competence in the field of adequate modeling of situations of reality. 

  9. Numerical Stability of Generalized Entropies

    CERN Document Server

    Steinbrecher, György

    2016-01-01

    In many applications, the probability density function is subject to experimental errors. In this work the continuos dependence of a class of generalized entropies on the experimental errors is studied. This class includes the C. Shannon, C. Tsallis, A. R\\'enyi and generalized R\\'enyi entropies. By using the connection between R\\'enyi or Tsallis entropies, and the "distance" in a family of metric functional spaces, family that includes the Lebesgue normed vector spaces, we introduce a further extensive generalizations of the R\\'enyi entropy. In this work we suppose that the experimental error is measured by some $L^{p}$ norm. In line with the methodology normally used for treating the so called "ill-posed problems", auxiliary stabilizing conditions are determined, such that small - in the sense of $L^{p}$ metric - experimental errors provoke small variations of the classical and generalized entropies. These stabilizing conditions are formulated in terms of $L^{p}$ metric in a class of generalized $L^{p}$ spac...

  10. UN Secretary General visits CERN

    CERN Multimedia

    2008-01-01

    UN Secretary General praises CERN in recent visit. Ban Ki-moon, Robert Aymar, CERN Director-General, and Sergei Ordzhonikidze, Director-General of the United Nations Office in Geneva at the CMS site.On Sunday 31 August, Ban Ki-moon, the UN Secretary General, made an important visit to CERN. Arriving in the late afternoon, he was warmly greeted at Point 5 by Robert Aymar, the Director-General, and the Sous-préfet of Gex, Olivier Laurens-Bernard. Accompanied by a UN delegation, Ban Ki-moon was also introduced to Jos Engelen, the Chief Scientific Officer, and Jim Virdee, the CMS spokesperson. He then took the opportunity to visit CMS and the machine tunnel. At the end of his short trip, Ban Ki-moon signed the Guest Book in the tradition of important dignitaries visiting CERN. Expressing his admiration for CERN’s spirit of collaboration, Ban Ki-moon said, "I am very honored to visit CERN, an invaluable scientific institution a...

  11. Generalized Fractional Integral Operators on Generalized Local Morrey Spaces

    Directory of Open Access Journals (Sweden)

    V. S. Guliyev

    2015-01-01

    Full Text Available We study the continuity properties of the generalized fractional integral operator Iρ on the generalized local Morrey spaces LMp,φ{x0} and generalized Morrey spaces Mp,φ. We find conditions on the triple (φ1,φ2,ρ which ensure the Spanne-type boundedness of Iρ from one generalized local Morrey space LMp,φ1{x0} to another LMq,φ2{x0}, 1

  12. ALGORITHMS FOR IMPLEMENTATION OF GENERAL LIMIT REPRESENTATIONS OF GENERALIZED INVERSES

    Institute of Scientific and Technical Information of China (English)

    Predarg S.Stanimirovic

    2001-01-01

    In this paper we investigate three various algorithms for computation of generalized inverses which are contained in the limit expressions and These algorithms are extensions of the algorithms developed by various authors in [2], [3-4], [7-9], [16-18].

  13. Development of a PCR technique specific for Demodex injai in biological specimens.

    Science.gov (United States)

    Sastre, N; Ravera, I; Ferreira, D; Altet, L; Sánchez, A; Bardagí, M; Francino, O; Ferrer, L

    2013-09-01

    The identification of Demodex injai as a second Demodex species of dog opened new questions and challenges in the understanding on the Demodex-host relationships. In this paper, we describe the development of a conventional PCR technique based on published genome sequences of D. injai from GenBank that specifically detects DNA from D. injai. This technique amplifies a 238-bp fragment corresponding to a region of the mitochondrial 16S rDNA of D. injai. The PCR was positive in DNA samples obtained from mites identified morphologically as D. injai, which served as positive controls, as well as in samples from three cases of demodicosis associated with proliferation of mites identified as D. injai. Furthermore, the PCR was positive in 2 out of 19 healthy dogs. Samples of Demodex canis and Demodex folliculorum were consistently negative. Skin samples from seven dogs with generalized demodicosis caused by D. canis were all negative in the D. injai-specific PCR, demonstrating that in generalized canine demodicosis, mite proliferation is species-specific. This technique can be a useful tool in the diagnosis and in epidemiologic and pathogenic studies.

  14. A Generalized Cubic Functional Equation

    Institute of Scientific and Technical Information of China (English)

    P. K. SAHOO

    2005-01-01

    In this paper, we determine the general solution of the functional equation f1 (2x + y) +f2(2x - y) = f3(x + y) + f4(x - y) + f5(x) without assuming any regularity condition on the unknown functions f1,f2,f3, f4,f5: R → R. The general solution of this equation is obtained by finding the general solution of the functional equations f(2x + y) + f(2x - y) = g(x + y) + g(x - y) + h(x) and f(2x + y) - f(2x - y) = g(x + y) - g(x - y). The method used for solving these functional equations is elementary but exploits an important result due to Hosszu. The solution of this functional equation can also be determined in certain type of groups using two important results due to Székelyhidi.

  15. CMAC with General Basis Functions.

    Science.gov (United States)

    Chun-Shin, Lin; Ching-Tsan, Chiang

    1996-10-01

    The cerebellar model articulation controller (CMAC) is often used in learning control. It can be viewed as a basis function network (BFN). The conventional CMAC uses local constant basis functions. A disadvantage is that its output is constant within each quantized state and the derivative information is not preserved. If the constant basis functions are replaced by non-constant differentiable basis functions, the derivative information will be able to be stored into the structure as well. In this paper, the generalized scheme that uses general basis functions is investigated. The conventional CMAC is a special case of the generalized technique. The mathematical foundation for the modified scheme is derived and the convergence of learning is proved. Simulations for the CMAC with Gaussian basis functions (GBFs) are performed to demonstrate the improvement of accuracy in modeling, and the capability in providing derivative information. Copyright 1996 Elsevier Science Ltd

  16. Generalization of the Euler Angles

    Science.gov (United States)

    Bauer, Frank H. (Technical Monitor); Shuster, Malcolm D.; Markley, F. Landis

    2002-01-01

    It is shown that the Euler angles can be generalized to axes other than members of an orthonormal triad. As first shown by Davenport, the three generalized Euler axes, hereafter: Davenport axes, must still satisfy the constraint that the first two and the last two axes be mutually perpendicular if these axes are to define a universal set of attitude parameters. Expressions are given which relate the generalized Euler angles, hereafter: Davenport angles, to the 3-1-3 Euler angles of an associated direction-cosine matrix. The computation of the Davenport angles from the attitude matrix and their kinematic equation are presented. The present work offers a more direct development of the Davenport angles than Davenport's original publication and offers additional results.

  17. A general approach to bosonization

    Indian Academy of Sciences (India)

    Girish S Setulur; V Meera

    2007-10-01

    We summarize recent developments in the field of higher dimensional bosonization made by Setlur and collaborators and propose a general formula for the field operator in terms of currents and densities in one dimension using a new ingredient known as a `singular complex number'. Using this formalism, we compute the Green function of the homogeneous electron gas in one spatial dimension with short-range interaction leading to the Luttinger liquid and also with long-range interactions that lead to a Wigner crystal whose momentum distribution computed recently exhibits essential singularities. We generalize the formalism to finite temperature by combining with the author's hydrodynamic approach. The one-particle Green function of this system with essential singularities cannot be easily computed using the traditional approach to bosonization which involves the introduction of momentum cutoffs, hence the more general approach of the present formalism is proposed as a suitable alternative.

  18. Pseudo-complex general relativity

    CERN Document Server

    Hess, Peter O; Greiner, Walter

    2016-01-01

    This volume presents an pseudo-complex extension of General Relativity which addresses these issues and presents proposals for experimental examinations in strong fields near a large mass. General Relativity is a beautiful and well tested theory of gravitation. Nevertheless, it implies conceptual problems like the creation of singularities (Black Holes) as a result of the collapse of large masses, or the appearance of event horizons which exclude parts of the space-time from the observation of external observers. The mathematical and geometrical foundations of this extension are displayed in detail, and applications including orbits and accretion disks around large central masses, neutron stars or cosmological models are introduced. Calculations both for classical and extended applications are often executed in the form of problems with extensive solutions, which makes this volume also a valuable resource for any student of General Relativity.

  19. Testing general relativity on accelerators

    CERN Document Server

    Kalaydzhyan, Tigran

    2015-01-01

    Within the general theory of relativity, the curvature of spacetime is related to the energy and momentum of the present matter and radiation. One of the more specific predictions of general relativity is the deflection of light and particle trajectories in the gravitational field of massive objects. Bending angles for electromagnetic waves and light in particular were measured with a high precision. However, the effect of gravity on relativistic massive particles was never studied experimentally. Here we propose and analyse experiments devoted to that purpose. We demonstrate a high sensitivity of the laser Compton scattering at high energy accelerators to the effects of gravity. The main observable -- maximal energy of the scattered photons -- would experience a significant shift in the Earth's gravitational field even for otherwise negligible violation of the equivalence principle. We confirm predictions of general relativity for ultrarelativistic electrons of energy of tens of GeV at a current level of res...

  20. General Purpose (office) Network reorganisation

    CERN Multimedia

    IT Department

    2016-01-01

    On Saturday 27 August, the IT Department’s Communication Systems group will perform a major reorganisation of CERN’s General Purpose Network.   This reorganisation will cause network interruptions on Saturday 27 August (and possibly Sunday 28 August) and will be followed by a change to the IP addresses of connected systems that will come into effect on Monday 3 October. For further details and information about the actions you may need to take, please see: https://information-technology.web.cern.ch/news/general-purpose-office-network-reorganisation.

  1. Spinning fluids in general relativity

    Science.gov (United States)

    Ray, J. R.; Smalley, L. L.

    1982-01-01

    General relativity field equations are employed to examine a continuous medium with internal spin. A variational principle formerly applied in the special relativity case is extended to the general relativity case, using a tetrad to express the spin density and the four-velocity of the fluid. An energy-momentum tensor is subsequently defined for a spinning fluid. The equations of motion of the fluid are suggested to be useful in analytical studies of galaxies, for anisotropic Bianchi universes, and for turbulent eddies.

  2. Generalized, Linear, and Mixed Models

    CERN Document Server

    McCulloch, Charles E; Neuhaus, John M

    2011-01-01

    An accessible and self-contained introduction to statistical models-now in a modernized new editionGeneralized, Linear, and Mixed Models, Second Edition provides an up-to-date treatment of the essential techniques for developing and applying a wide variety of statistical models. The book presents thorough and unified coverage of the theory behind generalized, linear, and mixed models and highlights their similarities and differences in various construction, application, and computational aspects.A clear introduction to the basic ideas of fixed effects models, random effects models, and mixed m

  3. A generalization of vortex lines

    CERN Document Server

    Fecko, Marian

    2016-01-01

    Helmholtz theorem states that, in ideal fluid, vortex lines move with the fluid. Another Helmholtz theorem adds that strength of a vortex tube is constant along the tube. The lines may be regarded as integral surfaces of an 1-dimensional integrable distribution (given by the vorticity 2-form). In general setting of theory of integral invariants, due to Poincare and Cartan, one can find $d$-dimensional integrable distribution whose integral surfaces show both properties of vortex lines: they move with (abstract) fluid and, for appropriate generalization of vortex tube, strength of the latter is constant along the tube.

  4. Generalized Painleve-Gullstrand metrics

    Energy Technology Data Exchange (ETDEWEB)

    Lin Chunyu [Department of Physics, National Cheng Kung University, Tainan 70101, Taiwan (China)], E-mail: l2891112@mail.ncku.edu.tw; Soo Chopin [Department of Physics, National Cheng Kung University, Tainan 70101, Taiwan (China)], E-mail: cpsoo@mail.ncku.edu.tw

    2009-02-02

    An obstruction to the implementation of spatially flat Painleve-Gullstrand (PG) slicings is demonstrated, and explicitly discussed for Reissner-Nordstroem and Schwarzschild-anti-deSitter spacetimes. Generalizations of PG slicings which are not spatially flat but which remain regular at the horizons are introduced. These metrics can be obtained from standard spherically symmetric metrics by physical Lorentz boosts. With these generalized PG metrics, problematic contributions to the imaginary part of the action in the Parikh-Wilczek derivation of Hawking radiation due to the obstruction can be avoided.

  5. Remarks on generalized toric codes

    CERN Document Server

    Little, John B

    2011-01-01

    This note presents some new information on how the minimum distance of the generalized toric code corresponding to a fixed set of integer lattice points S in R^2 varies with the base field. The main results show that in some cases, over sufficiently large fields, the minimum distance of the code corresponding to a set S will be the same as that of the code corresponding to the convex hull of S. In an example, we will also discuss a [49,12,28] generalized toric code over GF(8), better than any previously known code according to M. Grassl's online tables, as of July 2011.

  6. Multipole Expansion in Generalized Electrodynamics

    CERN Document Server

    Bonin, C A; Ortega, P H

    2016-01-01

    In this article we study some classical aspects of Podolsky Electrodynamics in the static regime. We develop the multipole expansion for the theory in both the electrostatic and the magnetostatic cases. We also address the problem of consistently truncating the infinite series associated with the several kinds of multipoles, yielding approximations for the static Podolskian electromagnetic field to any degree of precision required. Moreover, we apply the general theory of multipole expansion to some specific physical problems. In those problems we identify the first terms of the series with the monopole, dipole and quadrupole terms in the generalized theory. We also propose a situation in which Podolsky theory can be experimentally tested.

  7. Generalized quasi-dilaton theory

    CERN Document Server

    De Felice, Antonio; Mukohyama, Shinji

    2013-01-01

    Recently the first example of a unitary theory of Lorentz-invariant massive gravity allowing for stable self-accelerating de Sitter solutions was found, extending the quasidilaton theory. In this paper we further generalize this new action for the quasidilaton field by introducing general Lagrangian terms which are consistent with the quasidilaton symmetry while leading to second order equations of motion. We find that the structure of the theory, compared to the simplest stable example, does not change on introducing these new terms.

  8. Fourth order deformed general relativity

    CERN Document Server

    Cuttell, Peter D

    2014-01-01

    Whenever the condition of anomaly freedom is imposed within the framework of effective approaches to loop quantum cosmology, one seems to conclude that a deformation of general covariance is required. Here, starting from a general deformation we regain an effective gravitational Lagrangian including terms up to fourth order in extrinsic curvature. We subsequently constrain the form of the corrections, and then investigate the conditions for the occurrence of a big bounce and the realisation of an inflationary era, in the presence of a perfect fluid or scalar field.

  9. Uniform Acceleration in General Relativity

    CERN Document Server

    Friedman, Yaakov

    2016-01-01

    We extend de la Fuente and Romero's defining equation for uniform acceleration in a general curved spacetime from linear acceleration to the full Lorentz covariant uniform acceleration. In a flat spacetime background, we have explicit solutions. We use generalized Fermi-Walker transport to parallel transport the Frenet basis along the trajectory. In flat spacetime, we obtain velocity and acceleration transformations from a uniformly accelerated system to an inertial system. We obtain the time dilation between accelerated clocks. We apply our acceleration transformations to the motion of a charged particle in a constant electromagnetic field and recover the Lorentz-Abraham-Dirac equation.

  10. General relativity and gravitational waves

    CERN Document Server

    Weber, J

    2004-01-01

    An internationally famous physicist and electrical engineer, the author of this text was a pioneer in the investigation of gravitational waves. Joseph Weber's General Relativity and Gravitational Waves offers a classic treatment of the subject. Appropriate for upper-level undergraduates and graduate students, this text remains ever relevant. Brief but thorough in its introduction to the foundations of general relativity, it also examines the elements of Riemannian geometry and tensor calculus applicable to this field.Approximately a quarter of the contents explores theoretical and experimenta

  11. General Instructions for Disposable Respirators

    Centers for Disease Control (CDC) Podcasts

    2009-04-09

    This podcast, intended for the general public, demonstrates how to put on and take off disposable respirators that are to be used in areas affected by the influenza outbreak.  Created: 4/9/2009 by CDC, National Institute for Occupational Safety and Health (NIOSH).   Date Released: 4/29/2009.

  12. General Topology of the Universe

    OpenAIRE

    Pandya, Aalok

    2002-01-01

    General topology of the universe is descibed. It is concluded that topology of the present universe is greater or stronger than the topology of the universe in the past and topology of the future universe will be stronger or greater than the present topology of the universe. Consequently, the universe remains unbounded.

  13. On Generalized Derivations in Nearrings

    Directory of Open Access Journals (Sweden)

    Mohd Rais Khan

    2013-01-01

    Full Text Available The aim of this paper is to investigate some results of nearrings satisfying certain identities involving generalized derivations. Furthermore, we give some examples to demonstrate the restrictions imposed on the hypothesis of various results which are not superfluous.

  14. A General Introduction to Microcomputers.

    Science.gov (United States)

    Muiznieks, Viktors

    This basic introduction to microcomputers provides the neophyte with the terminology, definitions, and concepts that explain the microcomputer and computing technology in general. Mathematical operations with binary numbers, computer storage, controlling logic, and the concepts of stack and interrupt are explained. (RAO)

  15. Dimensional Analysis and General Relativity

    Science.gov (United States)

    Lovatt, Ian

    2009-01-01

    Newton's law of gravitation is a central topic in the first-year physics curriculum. A lecturer can go beyond the physical details and use the history of gravitation to discuss the development of scientific ideas; unfortunately, the most recent chapter in this history, general relativity, is not covered in first-year courses. This paper discusses…

  16. Fetal onset of general movements

    NARCIS (Netherlands)

    Luechinger, Annemarie B.; Hadders-Algra, Mijna; Van Kan, Colette M.; de Vries, JIP

    2008-01-01

    Perinatal qualitative assessment of general movements (GMs) is a tool to evaluate the integrity of the young nervous system. The aim of this investigation was to study the emergence of GMs. Fetal onset of GMs was studied sonographically in 18 fetuses during the first trimester of uncomplicated in vi

  17. General Laws and Centripetal Science

    NARCIS (Netherlands)

    Jagers Op Akkerhuis, G.A.J.M.

    2014-01-01

    The large number of discoveries in the last few decades has caused a scientific crisis that is characterised by overspecialisation and compartmentalisation. To deal with this crisis, scientists look for integrating approaches, such as general laws and unifying theories. Representing what can be

  18. New Zealand's first general anaesthetic.

    Science.gov (United States)

    Newson, A J

    1975-08-01

    The administration of New Zealand's first general anaesthetic took place at the Colonial Gaol, Wellington, on the morning of Monday, September 27th, 1847. The agent used was sulphuric ether which was administered by Mr. Marriot, the manufacturer of the Herapath-type inhaler used on this occasion. The operation, a dental extraction, was performed by the Colonial Surgeon, Dr. J. P. Fitzgerald.

  19. The elderly and general anesthesia

    DEFF Research Database (Denmark)

    Steinmetz, J; Rasmussen, L S

    2010-01-01

    Due to the aging population, the number of elderly patients taking advantage of healthcare services is increasing. A general physical decline of all organ systems and a high frequency of chronic disease accompanying aging.Comorbidity and polypharmacy are therefore common in the elderly. Hence, th...

  20. Good Phonic Generalizations for Decoding

    Science.gov (United States)

    Gates, Louis

    2007-01-01

    An exhaustive analysis of 88,641 individual letters and letter combinations within 16,928 words drawn from the Zeno, et al. word list unveiled remarkable phonic transparency. The individual letter and letter combinations sorted into just six general categories: three basic categories of vowels (single vowels, vowel digraphs, and final…

  1. Generalization: The Nature of Change.

    Science.gov (United States)

    Johnston, Judith R.

    1988-01-01

    Children's knowledge and control of a language pattern changes throughout the course of its acquisition. Language interventionists concerned about generalization may need to distinguish between activities that will promote rule learning and activities that will promote effortless rule utilization. (Author/DB)

  2. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  3. Dimensional Analysis and General Relativity

    Science.gov (United States)

    Lovatt, Ian

    2009-01-01

    Newton's law of gravitation is a central topic in the first-year physics curriculum. A lecturer can go beyond the physical details and use the history of gravitation to discuss the development of scientific ideas; unfortunately, the most recent chapter in this history, general relativity, is not covered in first-year courses. This paper discusses…

  4. GENERALIZED LENTIGINOSIS: AN UNCOMMON PRESENTATION

    Directory of Open Access Journals (Sweden)

    Valluvan

    2014-05-01

    Full Text Available A case of Generalized Lentiginosis is being documented for its rarity. A 27 years old congenitally deaf and mute, presented to our hospital with multiple asymmetrical brown-black to black colored macules involving all over the body sparing mucous membrane of oral cavity, palms and soles with melena. The patient was severely anemic on examination.

  5. THE GENERALIZED POLARIZATION SCATTERING MATRIX

    Science.gov (United States)

    the Least Square Best Estimate of the Generalized Polarization matrix from a set of measurements is then developed. It is shown that the Faraday...matrix data. It is then shown that the Least Square Best Estimate of the orientation angle of a symmetric target is also determinable from Faraday rotation contaminated short pulse monostatic polarization matrix data.

  6. Dynamics of generalized coherent states

    CERN Document Server

    De Martino, S; Illuminati, F; De Martino, S; De Siena, S; Illuminati, F

    1995-01-01

    We show that generalized coherent states follow Schr\\"{o}dinger dynamics in time-dependent potentials. The normalized wave-packets follow a classical evolution without spreading; in turn, the Schr\\"{o}dinger potential depends on the state through the classical trajectory. This feedback mechanism with continuous dynamical re-adjustement allows the packets to remain coherent indefinetely.

  7. Assessing the General Education Elephant

    Science.gov (United States)

    Eubanks, David A.

    2008-01-01

    Determining the success of a general education program can resemble the task of John Godfrey's six blind men in trying to acquaint themselves with an elephant. One man's approach is to feel the tusk and conclude that the elephant is a spear. Another approach leads to thinking that the broad side of the animal is a wall. The many ways of asking and…

  8. [Tetanus prophylaxis in general practice

    NARCIS (Netherlands)

    Boukes, F.S.; Wiersma, T.J.; Beaujean, D.; Burgmeijer, R.J.; Timen, A.

    2004-01-01

    In response to the report 'Immunisation against tetanus following injuries' from the Dutch Health Council, the Dutch College of General Practitioners, the National Coordinating Body for the Control of Infectious Diseases and The Netherlands Vaccine Institute have drawn up guidelines for tetanus

  9. General Laws and Centripetal Science

    NARCIS (Netherlands)

    Jagers Op Akkerhuis, G.A.J.M.

    2014-01-01

    The large number of discoveries in the last few decades has caused a scientific crisis that is characterised by overspecialisation and compartmentalisation. To deal with this crisis, scientists look for integrating approaches, such as general laws and unifying theories. Representing what can be cons

  10. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  11. Regularized Generalized Structured Component Analysis

    Science.gov (United States)

    Hwang, Heungsun

    2009-01-01

    Generalized structured component analysis (GSCA) has been proposed as a component-based approach to structural equation modeling. In practice, GSCA may suffer from multi-collinearity, i.e., high correlations among exogenous variables. GSCA has yet no remedy for this problem. Thus, a regularized extension of GSCA is proposed that integrates a ridge…

  12. General Recursion and Formal Topology

    Directory of Open Access Journals (Sweden)

    Silvio Valentini

    2010-12-01

    Full Text Available It is well known that general recursion cannot be expressed within Martin-Loef's type theory and various approaches have been proposed to overcome this problem still maintaining the termination of the computation of the typable terms. In this work we propose a new approach to this problem based on the use of inductively generated formal topologies.

  13. Burnout contagion among general practitioners.

    NARCIS (Netherlands)

    Bakker, A.B.; Schaufeli, W.B.; Sixma, H.J.; Bosveld, W.

    2001-01-01

    This study used a representative sample of 507 general practitioners (GPs) to test the hypothesis that burnout is contagious. Following a two-dimensional conceptualization of burnout, it is assumed that burnout is comprised of emotional exhaustion and negative attitudes (i.e., depersonalization and

  14. Games With General Coalitional Structure

    NARCIS (Netherlands)

    Selcuk, O.; Talman, A.J.J.

    2013-01-01

    Abstract: This paper introduces a new solution concept for cooperative games with general coalitional structure in which only certain sets of players, including the set of all players, are able to form feasible coalitions. The solution concept takes into account the marginal contribution of players.

  15. Sgr A* and General Relativity

    CERN Document Server

    Johannsen, Tim

    2015-01-01

    General relativity has been widely tested in weak gravitational fields but still stands largely untested in the strong-field regime. According to the no-hair theorem, black holes in general relativity depend only on their masses and spins and are described by the Kerr metric. Mass and spin are the first two multipole moments of the Kerr spacetime and completely determine all higher-order moments. The no-hair theorem and, hence, general relativity can be tested by measuring potential deviations from the Kerr metric affecting such higher-order moments. Sagittarius A* (Sgr A*) is a prime target for precision tests of general relativity with several experiments across the electromagnetic spectrum. First, near-infrared (NIR) monitoring of stars orbiting around Sgr A* with current and new instruments is expected to resolve their orbital precessions. Second, timing observations of radio pulsars near the Galactic center may detect characteristic residuals induced by the spin and quadrupole moment of Sgr A*. Third, th...

  16. Generalized no-broadcasting theorem.

    Science.gov (United States)

    Barnum, Howard; Barrett, Jonathan; Leifer, Matthew; Wilce, Alexander

    2007-12-14

    We prove a generalized version of the no-broadcasting theorem, applicable to essentially any nonclassical finite-dimensional probabilistic model satisfying a no-signaling criterion, including ones with "superquantum" correlations. A strengthened version of the quantum no-broadcasting theorem follows, and its proof is significantly simpler than existing proofs of the no-broadcasting theorem.

  17. Generalization of Selection Test Validity.

    Science.gov (United States)

    Colbert, G. A.; Taylor, L. R.

    1978-01-01

    This is part three of a three-part series concerned with the empirical development of homogeneous families of insurance company jobs based on data from the Position Analysis Questionnaire (PAQ). This part involves validity generalizations within the job families which resulted from the previous research. (Editor/RK)

  18. [Tetanus prophylaxis in general practice

    NARCIS (Netherlands)

    Boukes, F.S.; Wiersma, T.J.; Beaujean, D.; Burgmeijer, R.J.; Timen, A.

    2004-01-01

    In response to the report 'Immunisation against tetanus following injuries' from the Dutch Health Council, the Dutch College of General Practitioners, the National Coordinating Body for the Control of Infectious Diseases and The Netherlands Vaccine Institute have drawn up guidelines for tetanus prop

  19. Anisotropic Generalized Ghost Pilgrim Dark Energy Model in General Relativity

    Science.gov (United States)

    Santhi, M. Vijaya; Rao, V. U. M.; Aditya, Y.

    2017-02-01

    A spatially homogeneous and anisotropic locally rotationally symmetric (LRS) Bianchi type- I Universe filled with matter and generalized ghost pilgrim dark energy (GGPDE) has been studied in general theory of relativity. To obtain determinate solution of the field equations we have used scalar expansion proportional to the shear scalar which leads to a relation between the metric potentials. Some well-known cosmological parameters (equation of state (EoS) parameter ( ω Λ), deceleration parameter ( q) and squared speed of sound {vs2}) and planes (ω _{Λ }-dot {ω }_{Λ } and statefinder) are constructed for obtained model. The discussion and significance of these parameters is totally done through pilgrim dark energy parameter ( β) and cosmic time ( t).

  20. Mining Frequent Generalized Itemsets and Generalized Association Rules Without Redundancy

    Institute of Scientific and Technical Information of China (English)

    Daniel Kunkle; Donghui Zhang; Gene Cooperman

    2008-01-01

    This paper presents some new algorithms to efficiently mine max frequent generalized itemsets (g-itemsets) and essential generalized association rules (g-rules). These are compact and general representations for all frequent patterns and all strong association rules in the generalized environment. Our results fill an important gap among algorithms for frequent patterns and association rules by combining two concepts. First, generalized itemsets employ a taxonomy of items, rather than a fiat list of items. This produces more natural frequent itemsets and associations such as (meat, milk) instead of (beef, milk), (chicken, milk), etc. Second, compact representations of frequent itemsets and strong rules, whose result size is exponentially smaller, can solve a standard dilemma in mining patterns: with small threshold values for support and confidence, the user is overwhelmed by the extraordinary number of identified patterns and associations; but with large threshold values, some interesting patterns and associations fail to be identified. Our algorithms can also expand those max frequent g-itemsets and essential g-rules into the much larger set of ordinary frequent g-itemsets and strong g-rules. While that expansion is not recommended in most practical cases, we do so in order to present a comparison with existing algorithms that only handle ordinary frequent g-itemsets. In this case, the new algorithm is shown to be thousands, and in some cases millions, of the time faster than previous algorithms. Further, the new algorithm succeeds in analyzing deeper taxonomies, with the depths of seven or more. Experimental results for previous algorithms limited themselves to taxonomies with depth at most three or four. In each of the two problems, a straightforward lattice-based approach is briefly discussed and then a classificationbased algorithm is developed. In particular, the two classification-based algorithms are MFGI_class for mining max frequent g-itemsets and EGR

  1. Generalized isospin, generalized mass groups, and generalized Gell-Mann--Okubo formalism

    CERN Document Server

    Beaudoin, N; Sandapen, R

    2013-01-01

    The current concepts of isospin and baryon mass groups are only well-adapted to deal with baryon multiplets involving both the u and d quarks, and some other quark k. In this paper, we generalize isospin and mass groups to accommodate baryon multiplets involving quarks of any flavor, and the Gell-Mann--Okubo (GMO) formalism is generalized accordingly. Generalized isospin proves to be a simple and valuable framework when working in non-udk baryon multiplets, and provides new quantum numbers that allows us to distinguish \\Lambda-like baryons from \\Sigma-like baryons in the non-udk multiplets. The generalized GMO formalism allows us to quantify the quality of flavor symmetries seen in baryon multiplets, and also allows us to predict the masses of all observable J^P = 1/2^+ and 3/2^+ baryons with an estimated accuracy on the order of 50 MeV in the worst cases, on mass scales that span anywhere from 1000 MeV to 15000 MeV.

  2. Isotropic stars in general relativity

    CERN Document Server

    Mak, M K

    2013-01-01

    We present a general solution of the Einstein gravitational field equations for the static spherically symmetric gravitational interior spacetime of an isotropic fluid sphere. The solution is obtained by transforming the pressure isotropy condition, a second order ordinary differential equation, into a Riccati type first order differential equation, and using a general integrability condition for the Riccati equation. This allows us to obtain an exact non-singular solution of the interior field equations for a fluid sphere, expressed in the form of infinite power series. The physical features of the solution are studied in detail numerically by cutting the infinite series expansions, and restricting our numerical analysis by taking into account only $n=21$ terms in the power series representations of the relevant astrophysical parameters. In the present model all physical quantities (density, pressure, speed of sound etc.) are finite at the center of the sphere. The physical behavior of the solution essential...

  3. Some general random Taylor series

    Institute of Scientific and Technical Information of China (English)

    孙道椿; 余家荣

    1996-01-01

    Kahane has studied the value distribution of Gauss-Taylor series where is a complex Gauss sequence and The value distribution of more general random Taylor series is considered, where {Xn} is a sequence of real or complex random variables of independent, symmetric and equally distributed with finite non-zero fourth moment (the classical Gauss, Steinhaus and Rademacher random variables are special cases of such variables). First a theorem on the growth of characteristic functions is proved by a method which is completely different from Kahane’s. Then it is applied to proving that the range of general random Taylor series is almost surely dense everywhere in the complex plane and that if the random variable is bounded and continuous, the random series surely has no finite Nevanlinna deficient value.

  4. Generalizing Boolean Satisfiability II: Theory

    CERN Document Server

    Dixon, H E; Luks, E M; Parkes, A J; 10.1613/jair.1555

    2011-01-01

    This is the second of three planned papers describing ZAP, a satisfiability engine that substantially generalizes existing tools while retaining the performance characteristics of modern high performance solvers. The fundamental idea underlying ZAP is that many problems passed to such engines contain rich internal structure that is obscured by the Boolean representation used; our goal is to define a representation in which this structure is apparent and can easily be exploited to improve computational performance. This paper presents the theoretical basis for the ideas underlying ZAP, arguing that existing ideas in this area exploit a single, recurring structure in that multiple database axioms can be obtained by operating on a single axiom using a subgroup of the group of permutations on the literals in the problem. We argue that the group structure precisely captures the general structure at which earlier approaches hinted, and give numerous examples of its use. We go on to extend the Davis-Putnam-Logemann-...

  5. Acoustic reflex and general anaesthesia.

    Science.gov (United States)

    Farkas, Z

    1983-01-01

    Infant and small children are not always able to cooperate in impedance measurements. For this reason it was decided, -in special cases, -to perform acoustic reflex examination under general anaesthesia. The first report on stapedius reflex and general anaesthesia was published by Mink et al. in 1981. Under the effect of Tiobutabarbital, Propanidid and Diazepam there is no reflex response. Acoustic reflex can be elicited with Ketamin-hydrochlorid and Alphaxalone-alphadolone acetate narcosis. The reflex threshold remains unchanged and the amplitude of muscle contraction is somewhat increased. The method was used: 1. to assess the type and degree of hearing loss in children with cleft palate and/or lip prior to surgery. 2. to exclude neuromuscular disorders with indication of pharyngoplasties. 3. to quantify hearing level in children--mostly multiply handicapped--with retarded speech development. The results of Behavioral Observation and Impedance Audiometry are discussed and evaluated.

  6. Generalized eruptive histiocytosis mimicking leprosy

    Directory of Open Access Journals (Sweden)

    B C Sharath Kumar

    2011-01-01

    Full Text Available Generalized eruptive histiocytosis (GEH is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

  7. Generalized eruptive histiocytosis mimicking leprosy.

    Science.gov (United States)

    Sharath Kumar, B C; Nandini, A S; Niveditha, S R; Gopal, M G

    2011-01-01

    Generalized eruptive histiocytosis (GEH) is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage) of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

  8. General equilibrium without utility functions

    DEFF Research Database (Denmark)

    Balasko, Yves; Tvede, Mich

    2010-01-01

    How far can we go in weakening the assumptions of the general equilibrium model? Existence of equilibrium, structural stability and finiteness of equilibria of regular economies, genericity of regular economies and an index formula for the equilibria of regular economies have been known not to re......How far can we go in weakening the assumptions of the general equilibrium model? Existence of equilibrium, structural stability and finiteness of equilibria of regular economies, genericity of regular economies and an index formula for the equilibria of regular economies have been known...... and the diffeomorphism of the equilibrium manifold with a Euclidean space; (2) the diffeomorphism of the set of no-trade equilibria with a Euclidean space; (3) the openness and genericity of the set of regular equilibria as a subset of the equilibrium manifold; (4) for small trade vectors, the uniqueness, regularity...

  9. Solitons in generalized Galileon theories

    Science.gov (United States)

    Carrillo González, Mariana; Masoumi, Ali; Solomon, Adam R.; Trodden, Mark

    2016-12-01

    We consider the existence and stability of solitons in generalized Galileons, scalar-field theories with higher-derivative interactions but second-order equations of motion. It has previously been proven that no stable, static solitons exist in a single Galileon theory using an argument invoking the existence of zero modes for the perturbations. Here we analyze the applicability of this argument to generalized Galileons and discuss how this may be avoided by having potential terms in the energy functional for the perturbations or by including time dependence. Given the presence of potential terms in the Lagrangian for the perturbations, we find that stable, static solitons are not ruled out in conformal and (anti-)de Sitter Galileons. For the case of Dirac-Born-Infeld and conformal Galileons, we find that solitonic solutions moving at the speed of light exist, the former being stable and the latter unstable if the background soliton satisfies a certain condition.

  10. Solitons in generalized galileon theories

    CERN Document Server

    Carrillo-Gonzalez, Mariana; Solomon, Adam R; Trodden, Mark

    2016-01-01

    We consider the existence and stability of solitons in generalized galileons, scalar field theories with higher-derivative interactions but second-order equations of motion. It has previously been proven that no stable, static solitons exist in a single galileon theory using an argument invoking the existence of zero modes for the perturbations. Here we analyze the applicability of this argument to generalized galileons and discuss how this may be avoided by having potential terms in the energy functional for the perturbations, or by including time dependence. Given the presence of potential terms in the Lagrangian for the perturbations, we find that stable, static solitons are not ruled out in conformal and (A)dS galileons. For the case of DBI and conformal galileons, we find that solitonic solutions moving at the speed of light exist, the former being stable and the latter unstable if the background soliton satisfies a certain condition.

  11. Generalized Expression for Polarization Density

    Energy Technology Data Exchange (ETDEWEB)

    Lu Wang and T.S. Hahm

    2009-04-23

    A general polarization density which consists of classical and neoclassical parts is system-atically derived via modern gyrokinetics and bounce-kinetics by employing a phase-space Lagrangian Lie-transform perturbation method. The origins of polarization density are further elucidated. Extending the work on neoclassical polarization for long wavelength compared to ion banana width [M. N. Rosenbluth and F. L. Hinton, Phys. Rev. Lett. 80, 724 (1998)], an analytical formula for the generalized neoclassical polarization including both finite-banana-width (FBW) and finite-Larmor-radius (FLR) effects for arbitrary radial wavelength in comparison to banana width and gyroradius is derived. In additional to the contribution from trapped particles, the contribution of passing particles to the neoclassical polarization is also explicitly calculated. Our analytic expression agrees very well with the previous numerical results for a wide range of radial wavelength.

  12. Generalized sine-Gordon solitons

    Energy Technology Data Exchange (ETDEWEB)

    Santos, C dos [Centro de Fisica e Departamento de Fisica e Astronomia, Faculdade de Ciencias da Universidade do Porto, 4169-007 Porto (Portugal); Rubiera-Garcia, D, E-mail: cssilva@fc.up.pt, E-mail: rubieradiego@gmail.com [Departamento de Fisica, Universidad de Oviedo, Avenida Calvo Sotelo 18, 33007 Oviedo, Asturias (Spain)

    2011-10-21

    In this paper, we construct analytical self-dual soliton solutions in (1+1) dimensions for two families of models which can be seen as generalizations of the sine-Gordon system but where the kinetic term is non-canonical. For that purpose we use a projection method applied to the sine-Gordon soliton. We focus our attention on the wall and lump-like soliton solutions of these k-field models. These solutions and their potentials reduce to those of the Klein-Gordon kink and the standard lump for the case of a canonical kinetic term. As we increase the nonlinearity on the kinetic term the corresponding potentials get modified and the nature of the soliton may change, in particular, undergoing a topology modification. The procedure constructed here is shown to be a sort of generalization of the deformation method for a specific class of k-field models. (paper)

  13. More General Optimal Offset Assignment

    Directory of Open Access Journals (Sweden)

    Sven Mallach

    2015-06-01

    Full Text Available This manuscript presents exact approaches to the general offset assignment problem arising in the address code generation phase of compilers for application-specific processors. First, integer programming models for architecture-dependent and theoretically motivated special cases of the problem are established. Then, these models are extended to provide the first widely applicable formulations for the most general problem setting, supporting processors with several address registers and complex addressing capabilities. Existing heuristics are similarly extended and practical applicability of the proposed methods is demonstrated by experimental evaluation using an established and large benchmark set. The experiments allow us to study the impact of exploiting more complex memory addressing capabilities on the address computation costs of real-world programs. We also show how to integrate operand reordering techniques for commutative instructions into existing solution approaches.

  14. Generalized SU(2) Proca Theory

    CERN Document Server

    Allys, Erwan; Rodriguez, Yeinzon

    2016-01-01

    Following previous works on generalized Abelian Proca theory, also called vector galileon, we investigate the massive extension of a SU(2) gauge theory, i.e. the generalized SU(2) Proca model, which could be dubbed non-Abelian vector galileon. This particular symmetry group permits fruitful applications in cosmology such as inflation driven by gauge fields. Our approach consists in building in a exhaustive way all the Lagrangians containing up to six contracted Lorentz indices. For this purpose, and after identifying by group theoretical considerations all the independent Lagrangians which can be written at these orders, we consider the only linear combinations propagating three degrees of freedom and having healthy dynamics for their longitudinal mode, i.e. whose pure St\\"uckelberg contribution turns into the SU(2) multi-galileon dynamics. Finally, and after having considered the curved space-time expansion of these Lagrangians, we discuss the form of the theory at all subsequent orders.

  15. Stable clocks and general relativity

    CERN Document Server

    Will, C M

    1995-01-01

    We survey the role of stable clocks in general relativity. Clock comparisons have provided important tests of the Einstein Equivalence Principle, which underlies metric gravity. These include tests of the isotropy of clock comparisons (verification of local Lorentz invariance) and tests of the homogeneity of clock comparisons (verification of local position invariance). Comparisons of atomic clocks with gravitational clocks test the Strong Equivalence Principle by bounding cosmological variations in Newton's constant. Stable clocks also play a role in the search for gravitational radiation: comparision of atomic clocks with the binary pulsar's orbital clock has verified gravitational-wave damping, and phase-sensitive detection of waves from inspiralling compact binaries using laser interferometric gravitational observatories will facilitate extraction of useful source information from the data. Stable clocks together with general relativity have found important practical applications in navigational systems s...

  16. Is general relativity `essentially understood' ?

    CERN Document Server

    Friedrich, H

    2005-01-01

    The content of Einstein's theory of gravitation is encoded in the properties of the solutions to his field equations. There has been obtained a wealth of information about these solutions in the ninety years the theory has been around. It led to the prediction and the observation of physical phenomena which confirm the important role of general relativity in physics. The understanding of the domain of highly dynamical, strong field configurations is, however, still quite limited. The gravitational wave experiments are likely to provide soon observational data on phenomena which are not accessible by other means. Further theoretical progress will require, however, new methods for the analysis and the numerical calculation of the solutions to Einstein's field equations on large scales and under general assumptions. We discuss some of the problems involved, describe the status of the field and recent results, and point out some open problems.

  17. Generalized Lorenz-Mie theories

    CERN Document Server

    Gouesbet, Gérard

    2017-01-01

    This book explores generalized Lorenz–Mie theories when the illuminating beam is an electromagnetic arbitrary shaped beam relying on the method of separation of variables. The new edition includes an additional chapter covering the latest advances in both research and applications, which are highly relevant for readers. Although it particularly focuses on the homogeneous sphere, the book also considers other regular particles. It discusses in detail the methods available for evaluating beam shape coefficients describing the illuminating beam. In addition it features applications used in many fields such as optical particle sizing and, more generally, optical particle characterization, morphology-dependent resonances and the mechanical effects of light for optical trapping, optical tweezers and optical stretchers. Furthermore, it provides various computer programs relevant to the content.

  18. Generalization of the Proca Action

    Energy Technology Data Exchange (ETDEWEB)

    Heisenberg, Lavinia, E-mail: Lavinia.Heisenberg@unige.ch [Perimeter Institute for Theoretical Physics, 31 Caroline St. N, Waterloo, Ontario, N2L 2Y5 (Canada)

    2014-05-01

    We consider the Lagrangian of a vector field with derivative self-interactions with a priori arbitrary coefficients. Starting with a flat space-time we show that for a special choice of the coefficients of the self-interactions the ghost-like pathologies disappear. This constitutes the Galileon-type generalization of the Proca action with only three propagating physical degrees of freedom. The longitudinal mode of the vector field is associated to the usual Galileon interactions for a specific choice of the overall functions. In difference to a scalar Galileon theory, the generalized Proca field has more free parameters. We then extend this analysis to a curved background. The resulting theory is the Horndeski Proca action with second order equations of motion on curved space-times.

  19. Generalization of the Proca Action

    CERN Document Server

    Heisenberg, Lavinia

    2014-01-01

    We consider the Lagrangian of a vector field with derivative self-interactions with a priori arbitrary coefficients. Starting with a flat space-time we show that for a special choice of the coefficients of the self-interactions the ghost-like pathologies disappear. This constitutes the Galileon-type generalization of the Proca action with only three propagating physical degrees of freedom. The longitudinal mode of the vector field is associated to the usual Galileon interactions. In difference to a scalar Galileon theory, the generalized Proca field has more free parameters. We then extend this analysis to a curved background. The resulting theory is the Horndeski Proca action with second order equations of motion on curved space-times.

  20. General Construction of Tubular Geometry

    CERN Document Server

    Mukhopadhyay, Partha

    2016-01-01

    We consider the problem of locally describing tubular geometry around a submanifold embedded in a (pseudo)Riemannian manifold in its general form. Given the geometry of ambient space in an arbitrary coordinate system and equations determining the submanifold in the same system, we compute the tubular expansion coefficients in terms of this {\\it a priori data}. This is done by using an indirect method that crucially applies the tubular expansion theorem for vielbein previously derived. With an explicit construction involving the relevant coordinate and non-coordinate frames we verify consistency of the whole method up to quadratic order in vielbein expansion. Furthermore, we perform certain (long and tedious) higher order computation which verifies the first non-trivial spin connection term in the expansion for the first time. Earlier a similar method was used to compute tubular geometry in loop space. We explain this work in the light of our general construction.

  1. General relativity and relativistic astrophysics

    CERN Document Server

    Mukhopadhyay, Banibrata

    2016-01-01

    Einstein established the theory of general relativity and the corresponding field equation in 1915 and its vacuum solutions were obtained by Schwarzschild and Kerr for, respectively, static and rotating black holes, in 1916 and 1963, respectively. They are, however, still playing an indispensable role, even after 100 years of their original discovery, to explain high energy astrophysical phenomena. Application of the solutions of Einstein's equation to resolve astrophysical phenomena has formed an important branch, namely relativistic astrophysics. I devote this article to enlightening some of the current astrophysical problems based on general relativity. However, there seem to be some issues with regard to explaining certain astrophysical phenomena based on Einstein's theory alone. I show that Einstein's theory and its modified form, both are necessary to explain modern astrophysical processes, in particular, those related to compact objects.

  2. Generalized Nanosatellite Avionics Testbed Lab

    Science.gov (United States)

    Frost, Chad R.; Sorgenfrei, Matthew C.; Nehrenz, Matt

    2015-01-01

    The Generalized Nanosatellite Avionics Testbed (G-NAT) lab at NASA Ames Research Center provides a flexible, easily accessible platform for developing hardware and software for advanced small spacecraft. A collaboration between the Mission Design Division and the Intelligent Systems Division, the objective of the lab is to provide testing data and general test protocols for advanced sensors, actuators, and processors for CubeSat-class spacecraft. By developing test schemes for advanced components outside of the standard mission lifecycle, the lab is able to help reduce the risk carried by advanced nanosatellite or CubeSat missions. Such missions are often allocated very little time for testing, and too often the test facilities must be custom-built for the needs of the mission at hand. The G-NAT lab helps to eliminate these problems by providing an existing suite of testbeds that combines easily accessible, commercial-offthe- shelf (COTS) processors with a collection of existing sensors and actuators.

  3. Multivariate covariance generalized linear models

    DEFF Research Database (Denmark)

    Bonat, W. H.; Jørgensen, Bent

    2016-01-01

    We propose a general framework for non-normal multivariate data analysis called multivariate covariance generalized linear models, designed to handle multivariate response variables, along with a wide range of temporal and spatial correlation structures defined in terms of a covariance link...... function combined with a matrix linear predictor involving known matrices. The method is motivated by three data examples that are not easily handled by existing methods. The first example concerns multivariate count data, the second involves response variables of mixed types, combined with repeated...... are fitted by using an efficient Newton scoring algorithm based on quasi-likelihood and Pearson estimating functions, using only second-moment assumptions. This provides a unified approach to a wide variety of types of response variables and covariance structures, including multivariate extensions...

  4. Generalized Lorenz-Mie Theories

    CERN Document Server

    Gouesbet, Gérard

    2011-01-01

    The Lorenz-Mie theory, describing the interaction between a homogeneous sphere and an electromagnetic plane wave, is likely to be one of the most famous theories in light scattering. But, with the advent of lasers and their increasing development in various fields, it has become too old-fashioned to meet most of the modern requisites. The book deals with generalized Lorenz-Mie theories when the illuminating beam is an electromagnetic arbitrary shaped beam, relying on the method of separation of variables. A particular emphasis is stressed on the case of the homogeneous sphere but other regular particles are considered too. An extensive discussion of the methods available to the evaluation of beam shape coefficients describing the illuminating beam is provided, and several methods are discussed. Applications concern many fields such as optical particle sizing and, more generally, optical particle characterization, morphology-dependent resonances, or mechanical effects of light for optical trapping, optical twe...

  5. Kernel Generalized Noise Clustering Algorithm

    Institute of Scientific and Technical Information of China (English)

    WU Xiao-hong; ZHOU Jian-jiang

    2007-01-01

    To deal with the nonlinear separable problem, the generalized noise clustering (GNC) algorithm is extended to a kernel generalized noise clustering (KGNC) model. Different from the fuzzy c-means (FCM) model and the GNC model which are based on Euclidean distance, the presented model is based on kernel-induced distance by using kernel method. By kernel method the input data are nonlinearly and implicitly mapped into a high-dimensional feature space, where the nonlinear pattern appears linear and the GNC algorithm is performed. It is unnecessary to calculate in high-dimensional feature space because the kernel function can do itjust in input space. The effectiveness of the proposed algorithm is verified by experiments on three data sets. It is concluded that the KGNC algorithm has better clustering accuracy than FCM and GNC in clustering data sets containing noisy data.

  6. General benchmarks for quantum repeaters

    CERN Document Server

    Pirandola, Stefano

    2015-01-01

    Using a technique based on quantum teleportation, we simplify the most general adaptive protocols for key distribution, entanglement distillation and quantum communication over a wide class of quantum channels in arbitrary dimension. Thanks to this method, we bound the ultimate rates for secret key generation and quantum communication through single-mode Gaussian channels and several discrete-variable channels. In particular, we derive exact formulas for the two-way assisted capacities of the bosonic quantum-limited amplifier and the dephasing channel in arbitrary dimension, as well as the secret key capacity of the qubit erasure channel. Our results establish the limits of quantum communication with arbitrary systems and set the most general and precise benchmarks for testing quantum repeaters in both discrete- and continuous-variable settings.

  7. Group supervision for general practitioners

    DEFF Research Database (Denmark)

    Galina Nielsen, Helena; Sofie Davidsen, Annette; Dalsted, Rikke;

    2013-01-01

    AIM: Group supervision is a sparsely researched method for professional development in general practice. The aim of this study was to explore general practitioners' (GPs') experiences of the benefits of group supervision for improving the treatment of mental disorders. METHODS: One long...... considered important prerequisites for disclosing and discussing professional problems. CONCLUSION: The results of this study indicate that participation in a supervision group can be beneficial for maintaining and developing GPs' skills in dealing with patients with mental health problems. Group supervision......-established supervision group was studied closely for six months by observing the group sessions, and by interviewing GPs and their supervisors, individually and collectively. The interviews were recorded digitally and transcribed verbatim. The data were analysed using systematic text condensation. RESULTS: The GPs found...

  8. Generalized SU(2) Proca theory

    Science.gov (United States)

    Allys, Erwan; Peter, Patrick; Rodríguez, Yeinzon

    2016-10-01

    Following previous works on generalized Abelian Proca theory, also called vector Galileon, we investigate the massive extension of an SU(2) gauge theory, i.e., the generalized SU(2) Proca model, which could be dubbed non-Abelian vector Galileon. This particular symmetry group permits fruitful applications in cosmology such as inflation driven by gauge fields. Our approach consists in building, in an exhaustive way, all the Lagrangians containing up to six contracted Lorentz indices. For this purpose, and after identifying by group theoretical considerations all the independent Lagrangians which can be written at these orders, we consider the only linear combinations propagating 3 degrees of freedom and having healthy dynamics for their longitudinal mode, i.e., whose pure Stückelberg contribution turns into the SU(2) multi-Galileon dynamics. Finally, and after having considered the curved space-time expansion of these Lagrangians, we discuss the form of the theory at all subsequent orders.

  9. Quantum walks on general graphs

    CERN Document Server

    Kendon, V

    2003-01-01

    A scheme for a discrete time quantum walk on a general graph of N vertices with undirected edges is given, and compared with the continuous time quantum walk on a general graph introduced by Farhi and Gutmann [PRA 58 915 (1998)]. Both walks are contrasted with the examples of quantum walks in the literature treating graphs of fixed, small (< log N) degree. This illustrates the way in which extra information about the graph allows more efficient algorithms to be designed. To obtain a quantum speed up over classical for comparable resources it is necessary to code the position space of the quantum walk into a qubit register (or equivalent). The role of the oracle is also discussed and an efficient gate sequence is presented for implementing a discrete quantum walk given one copy of a quantum state encoding the adjacency matrix of the graph.

  10. Generalizations of the Kunen Inconsistency

    CERN Document Server

    Hamkins, Joel David; Perlmutter, Norman Lewis

    2011-01-01

    We present several generalizations of the well-known Kunen inconsistency that there is no nontrivial elementary embedding from the set-theoretic universe V to itself. For example, there is no elementary embedding from the universe V to a set-forcing extension V[G], or conversely from V[G] to V, or more generally from one ground model of the universe to another, or between any two models that are eventually stationary correct, or from V to HOD, or conversely from HOD to V, or indeed from any definable class to V, among many other possibilities we consider, including generic embeddings, definable embeddings and results not requiring the axiom of choice. We have aimed in this article for a unified presentation that weaves together some previously known unpublished or folklore results, several due to Woodin and others, along with our new contributions.

  11. The genesis of general relativity

    CERN Document Server

    Norton, John; Renn, Jürgen; Sauer, Tilman; Stachel, John

    2007-01-01

    This four-volume work represents the most comprehensive documentation and study of the creation of general relativity; one of the fundamental physical theories of the 20th century. It comprises key sources from Einstein and others who from the late 19th to the early 20th century contributed to this monumental development. Some of these sources are presented here in translation for the first time. Einstein’s famous Zurich notebook, which documents the pivotal steps toward general relativity, is reproduced here for the first time and transcribed in its entirety. The volumes offer detailed commentaries and analyses of these sources that are based on a close reading of these documents supplemented by interpretations by the leading historians of relativity. All in all, the facets of this work, based on more than a decade of research, combine to constitute one of the most in-depth studies of a scientific revolution ever written.

  12. Quantum information and general relativity

    CERN Document Server

    Peres, A

    2004-01-01

    The Einstein-Podolsky-Rosen paradox (1935) is reexamined in the light of Shannon's information theory (1948). The EPR argument did not take into account that the observers' information was localized, like any other physical object. General relativity introduces new problems: there are horizons which act as one-way membranes for the propagation of quantum information, in particular black holes which act like sinks.

  13. General footage ISOLDE experimental hall

    CERN Multimedia

    2016-01-01

    Overview of the ISOLDE experimental hall. Equipment and experiments. Taken from the WITCH / EBIS platform: ISOLDE hall infrastructure, GHM line, LA1, LA2, LA0, central beamline, COLLAPS experiment, CRIS experiment, ISOLTRAP experiment, laser guidance from building 508 into the hall for laser spectroscopy COLLAPS and CRIS. Taken from the HIE ISOLDE shielding tunnel roof: ISOLDE hall infrastructure, WITCH experiment, VITO line, TAS experiment. General footage: High Tension room entrance and EBIS platform, staircases and passages in the experimental hall.

  14. General relativity 50 years old

    CERN Multimedia

    1966-01-01

    In May 1916, 'The Foundations of General Relativity Theory' by Albert Einstein was published in 'Annalen der Physik'. Fifty years later, this major contribution to scientific thought still has a rather isolated position with respect to the main-stream of scientific theory. (In contrast, the Special Theory of Relativity is one of the cornerstones of sub-nuclear physics.) To mark the anniversary of the publication of Einstein's paper a theoretician from CERN discusses the theory and its present status.

  15. Annual Progress report - General Task

    Energy Technology Data Exchange (ETDEWEB)

    Wesnousky, S.G.

    1993-09-30

    This report provides a summary of progress for the project {open_quotes}Evaluation of the Geologic Relations and Seismotectonic Stability of the Yucca Mountain Area, Nevada Nuclear Waste Site Investigation (NNWSI).{close_quotes} A similar report was previously provided for the period of 1 October 1991 to 30 September 1992. The report initially covers the activities of the General Task and is followed by sections that describe the progress of the other ongoing tasks.

  16. General Relativity in Electrical Engineering

    OpenAIRE

    Leonhardt, Ulf; Philbin, Thomas G.

    2006-01-01

    In electrical engineering metamaterials have been developed that offer unprecedented control over electromagnetic fields. Here we show that general relativity lends the theoretical tools for designing devices made of such versatile materials. Given a desired device function, the theory describes the electromagnetic properties that turn this function into fact. We consider media that facilitate space-time transformations and include negative refraction. Our theory unifies the concepts operatin...

  17. General sGoldstino Inflation

    CERN Document Server

    Ferrara, Sergio

    2016-01-01

    We prove that all inflationary models, including those with dark energy after the end of inflation, can be embedded in minimal supergravity with a single chiral superfield. Moreover, the amount of supersymmetry breaking is independently tunable due to a degeneracy in the choice for the superpotential. The inflaton is a scalar partner of the Goldstino in this set-up. We illustrate our general procedure with two examples that are favoured by the Planck data.

  18. Generalized Superconductors and Holographic Optics

    CERN Document Server

    Mahapatra, Subhash; Sarkar, Tapobrata

    2013-01-01

    We study generalized holographic s-wave superconductors in four dimensional R-charged black hole backgrounds, in the probe limit. We first establish the superconducting nature of the boundary theory, and then study its optical properties. Numerical analysis indicates that a negative index of refraction appears at low frequencies in the theory, for certain temperature ranges, for specific values of the charge parameter. The corresponding cut-off values for these are numerically established in several cases.

  19. Nutrition intervention in general dentistry.

    Science.gov (United States)

    Sintes, J L

    1990-12-01

    This article presents a nutrition program in general dentistry following an oral health nutrition care process, and provides a guideline for identifying patients at risk of developing marginal malnutrition as a result of oral health procedures. The program highlights the importance of assessing nutritional status by segregating high-risk patients from low-risk patients. A case report demonstrates the therapeutic dietary management of a patient whose jaws were immobilized as a result of trauma.

  20. Generalized Stieltjes transforms: basic aspects

    CERN Document Server

    Karp, Dmitry

    2011-01-01

    The paper surveys the basic properties of generalized Stieltjes functions including some new ones. We introduce the notion of exact Stieltjes order and give a criterion of exactness, simple sufficient conditions and some prototypical examples. The paper includes an appendix, where we define the left sided Riemann-Liouville and the right sided Kober-Erdelyi fractional integrals of measures supported on half axis and give inversion formulas for them.