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Sample records for juvenile brown treesnakes

  1. Prey preferences and prey acceptance in juvenile Brown Treesnakes (Boiga irregularis)

    Science.gov (United States)

    Lardner, Bjorn; Savidge, Julie A.; Rodda, Gordon H.; Reed, Robert N.

    2009-01-01

    On the Pacific island of Guam, control of the invasive Brown Treesnake (Boiga irregularis) relies largely on methods that use mice as bait. Juvenile B. irregularis feed primarily on lizards and their eggs, but little is known about their prey preference. We conducted an experiment to investigate preferences for, and acceptance of, dead geckos, skinks, and neonatal mice, in juvenile B. irregularis ranging from 290 mm to ca. 700 mm snout-vent length (SVL). Snakes of all sizes showed a preference for geckos over skinks and neonatal mice. Geckos were the first prey chosen in 87% of 224 initial trials (56 snakes subjected to four trials each; 33% would be expected from a random choice). The smallest snakes had the most pronounced preference. Although many of the snakes accepted neonatal mice and/or skinks, some snakes of all sizes were reluctant to feed on anything but geckos, especially when well fed. We also addressed the hypothesis that repeated encounters with a particular prey type increase a snake's preference for that prey. Our study does not support this hypothesis. Our results suggest that control methods relying solely on rodent bait may be inefficient for targeting snakes < 700 mm SVL and that individual heterogeneity in prey preference may cause a significant part of this juvenile cohort to be completely refractory to capture with rodent bait, even if the bait is dead and small enough to be readily swallowed.

  2. Invasive Brown Treesnake movements at road edges indicate road-crossing avoidance

    Science.gov (United States)

    Siers, Shane R.; Savidge, Julie S; Reed, Robert N.

    2014-01-01

    Roads have significant impacts on the dispersal of wildlife. Although this poses a threat to the abundance and diversity of desirable flora and fauna, it also affords some opportunity for enhancing control of invasive species. Roads are the most common terrain features that may affect the rate of landscape-scale movements of invasive Brown Treesnakes (Boiga irregularis) throughout Guam. We radio tracked 45 free-ranging Brown Treesnakes in close proximity to two roads in Guam and recorded instances where daily relocations of snakes spanned roads. Then we reconstructed observed movement histories with randomized turning angles, which served as a useful null hypothesis for assessing the effect of roads or road edge habitat on Brown Treesnake movement patterns. Random walk simulations demonstrated that Brown Treesnakes crossed these roads at a rate far lower than would be expected if snake movement was random with respect to roads and road edge habitat. We discuss two alternative hypotheses for these results: 1) habitat gaps posed by roads physically or behaviorally restrict snake movement; or 2) road edges provide preferred foraging habitat from which snakes are reluctant to depart. Because roads often form the boundaries of jurisdictional and management units, the effects of roads on the movement of invasive Brown Treesnakes will influence the prospects for success of future landscape-level suppression efforts.

  3. Canine detection of free-ranging brown treesnakes on Guam

    Science.gov (United States)

    Savidge, J.A.; Stanford, J.W.; Reed, R.N.; Haddock, G.R.; Adams, A.A.Y.

    2011-01-01

    We investigated canine teams (dogs and their handlers) on Guam as a potential tool for finding invasive brown treesnakes (Boiga irregularis) in the wild. Canine teams searched a 40 ?? 40 m forested area for a snake that had consumed a dead mouse containing a radio-transmitter. To avoid tainting the target or target area with human scent, no snake was handled or closely approached prior to searches. Trials were conducted during the morning when these nocturnal snakes were usually hidden in refugia. A radiotracker knew the snake's location, but dog handlers and search navigators did not. Of 85 trials conducted over four months, the two canine teams had an average success rate of 35% of correctly defining an area ??? 5 ?? 5 m that contained the transmittered snake; the team with more experience prior to the trials had a success rate of 44% compared with 26% for the less experienced team. Canine teams also found 11 shed skins from wild snakes. Although dogs alerted outside the vicinity of transmittered snakes, only one wild, non-transmittered snake was found during the trials, possibly reflecting the difficulty humans have in locating non-transmittered brown treesnakes in refugia. We evaluated success at finding snakes as a function of canine team, number of prior trials (i.e. experience gained during the trials), recent canine success at finding a target snake, various environmental conditions, snake perch height, and snake characteristics (snout-vent length and sex). Success rate increased over the course of the trials. Canine team success also increased with increasing average humidity and decreased with increasing average wind speed. Our results suggest dogs could be useful at detecting brown treesnakes in refugia, particularly when compared to daytime visual searches by humans, but techniques are needed to help humans find and extract snakes once a dog has alerted. ?? New Zealand Ecological Society.

  4. Factors affecting defensive strike behavior in Brown Treesnakes (Boiga irregularis) provoked by humans

    Science.gov (United States)

    Spencer, McKayka M.; Lardner, Bjorn; Mazurek, M.J.; Reed, Robert N.

    2015-01-01

    Striking is a typical antipredator defense exhibited by many species of snakes. While trapping Brown Treesnakes (Boiga irregularis) on Guam, we observed that snakes most frequently struck at an approaching person at a site where snakes had been trapped, marked, and handled in the past. Using a combination of between-sites and within-site comparisons, we assessed if the propensity to strike was correlated with capture histories (both recent and long-term), snake size, body condition (a proxy to nutritional stress), sex, or tail condition (broken or intact), while controlling for confounding variables. We confirmed that propensity to strike was higher at the site where we had been conducting capture-mark-recapture for several years. However, we were unable to demonstrate a correlation between striking tendencies and individual recent or long-term capture histories. The only morphological covariate that had an effect on strike propensity was sex, with females striking more often than males. After removing the site effect from our model, we found that snakes missing parts of their tails were more likely to strike than snakes with intact tails. We have yet to identify the factor(s) that cause the pronounced difference across sites in snake propensity to strike, and data from additional sites might help elucidate any geographical patterns.

  5. Effectiveness of bait tubes for brown treesnake control on Guam

    Science.gov (United States)

    Lardner, B.; Savidge, J.A.; Rodda, G.H.; Reed, R.N.; Yackel Adams, A.A.; Clark, C.S.

    2011-01-01

    A bait tube is a device with which a toxicant inserted in a dead mouse (Mus musculus) can be delivered to invasive brown treesnakes (Boiga irregularis) with low risk of non-target bait take. We tested two bait tube designs in a 5ha snake enclosure where the identity of virtually every snake is known. Instead of using toxicants, we implanted radio transmitters in small (6.6±1.4 g) and large (21.8±2.9 g) bait mice. Knowing all snakes present in the population allowed us to characterize not only covariates of snakes taking bait, but also those of snakes evading our mock control effort, and if snake covariates interacted with any design variable in determining targeting rate. Tube design had no effect on take rate. Snake snout-vent length was a strong predictor of success: none of the 29 snakes smaller than 843 mm took any bait, while the 126 snakes ≥843 mm were responsible for a total of 164 bait takes. The smallest of these snakes were able to ingest small and large mice, but tended to consume small bait at a higher rate than large bait. The main reason for our failure to target smallest snakes appears not to be gape limitation, but rather that small snakes prefer other prey (lizards). The time it takes a snake to grow from the size threshold observed to the size of maturation has implications for the interval between discrete efforts using toxic bait. Targeting all snakes before reproduction can occur is highly desirable; otherwise, a new cohort of refractory snakes may enter the population.

  6. Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.

    Science.gov (United States)

    Pla, Davinia; Petras, Daniel; Saviola, Anthony J; Modahl, Cassandra M; Sanz, Libia; Pérez, Alicia; Juárez, Elena; Frietze, Seth; Dorrestein, Pieter C; Mackessy, Stephen P; Calvete, Juan J

    2018-03-01

    The Brown Treesnake (Boiga irregularis) is an arboreal, nocturnal, rear-fanged venomous snake native to northern and eastern regions of Australia, Papua New Guinea and the Solomon Islands. It was inadvertently introduced onto the island of Guam during the late 1940's to early 1950's, and it has caused massive declines and extirpations of the native bird, lizard, and mammal populations. In the current study, we report the characterization of the venom proteome of an adult and a neonate B. irregularis specimens from Guam by a combination of venom gland transcriptomic and venomic analyses. Venom gland transcriptomic analysis of an adult individual identified toxins belonging to 18 protein families, with three-finger toxin isoforms being the most abundantly expressed transcripts, comprising 94% of all venom protein transcript reads. Transcripts for PIII-metalloproteinases, C-type lectins, cysteine-rich secretory proteins, acetylcholinesterases, natriuretic peptides, ficolins, phospholipase A 2 (PLA 2 ) inhibitors, PLA 2 s, vascular endothelial growth factors, Kunitz-type protease inhibitors, cystatins, phospholipase Bs, cobra venom factors, waprins, SVMP inhibitors, matrix metalloproteinases, and hyaluronidases were also identified, albeit, at very low abundances ranging from 0.05% to 1.7% of the transcriptome. The venom proteomes of neonate and adult B. irregularis were also both overwhelmingly (78 and 84%, respectively) dominated by monomeric and dimeric 3FTxs, followed by moderately abundant (21% (N) and 13% (A)) CRISPs, low abundance (1% (N), 3% (A)) PIII-SVMPs, and very low abundance (blot analysis showed that all venom proteins were recognized by anti-BTS IgGs, and cross-reactivity with other rear-fanged snake venoms was also observed. Incubation of anti-BTS venom IgGs with crude B. irregularis venom resulted in a significant decrease in proteolytic (SVMP) activity against azocasein. These results provide the first comparative venomic and anti-venomic analysis of

  7. Scented guide ropes as a method to enhance brown treesnake (Boiga irregularis) trap capture success on Guam

    Science.gov (United States)

    Mason, L.C.; Savidge, J.A.; Rodda, G.H.; Yackel Adams, A.A.

    2011-01-01

    Current methods for controlling the invasive Brown Treesnake (Boiga irregularis) on Guam include a modified minnow trap with a live mouse lure. We investigated the effects on capture success of augmenting these traps with scented guide ropes leading to trap entrances. Initial screening of scent preferences was based on time spent in scented and unscented arms of a Y-maze. Preferences of large and small snakes were scored for six different prey scents (live and carrion gecko, skink, and mouse). Large snakes spent more time in the maze arm scented with live gecko and carrion gecko, whereas small snakes spent more time in the arm scented with carrion mouse and carrion gecko. After the laboratory study, a pilot trapping session was conducted in the field using three treatments (live mouse-scented ropes, carrion gecko-scented ropes, and carrion mouse-scented ropes) and two controls (traps with unscented guide ropes and those with no ropes attached). Contrary to laboratory results, live mouse-scented ropes were most effective. We conducted a second trapping session using live mouse-scented ropes as well as the two controls used in the pilot study. For snakes of below-average to average condition, the number of captures for traps with live mouse-scented ropes was higher than for traps with no ropes. However, for snakes of above-average condition, there were no differences in capture rates between trap treatments. Overall, treatment effects were weaker than latent individual heterogeneity and the influence of snake body size, with large snakes trapped more readily. ?? 2011 Society for the Study of Amphibians and Reptiles.

  8. The effects of chronological age and size on toxicity of zinc to juvenile brown trout

    Science.gov (United States)

    A series of toxicity tests were conducted to investigate the role of chronological age and organism weight on zinc tolerance in juvenile brown trout (Salmo trutta). Four different incubation temperatures were used to control the maturation of the juveniles prior to zinc exposure...

  9. Evaluation of trap capture in a geographically closed population of brown treesnakes on Guam

    Science.gov (United States)

    Tyrrell, C.L.; Christy, M.T.; Rodda, G.H.; Yackel Adams, A.A.; Ellingson, A.R.; Savidge, J.A.; Dean-Bradley, K.; Bischof, R.

    2009-01-01

    1. Open population mark-recapture analysis of unbounded populations accommodates some types of closure violations (e.g. emigration, immigration). In contrast, closed population analysis of such populations readily allows estimation of capture heterogeneity and behavioural response, but requires crucial assumptions about closure (e.g. no permanent emigration) that are suspect and rarely tested empirically. 2. In 2003, we erected a double-sided barrier to prevent movement of snakes in or out of a 5-ha semi-forested study site in northern Guam. This geographically closed population of >100 snakes was monitored using a series of transects for visual searches and a 13 ?? 13 trapping array, with the aim of marking all snakes within the site. Forty-five marked snakes were also supplemented into the resident population to quantify the efficacy of our sampling methods. We used the program mark to analyse trap captures (101 occasions), referenced to census data from visual surveys, and quantified heterogeneity, behavioural response, and size bias in trappability. Analytical inclusion of untrapped individuals greatly improved precision in the estimation of some covariate effects. 3. A novel discovery was that trap captures for individual snakes consisted of asynchronous bouts of high capture probability lasting about 7 days (ephemeral behavioural effect). There was modest behavioural response (trap happiness) and significant latent (unexplained) heterogeneity, with small influences on capture success of date, gender, residency status (translocated or not), and body condition. 4. Trapping was shown to be an effective tool for eradicating large brown treesnakes Boiga irregularis (>900 mm snout-vent length, SVL). 5. Synthesis and applications. Mark-recapture modelling is commonly used by ecological managers to estimate populations. However, existing models involve making assumptions about either closure violations or response to capture. Physical closure of our population on a

  10. Daytime habitat selection for juvenile parr brown trout (Salmo trutta) in small lowland streams

    DEFF Research Database (Denmark)

    Conallin, J.; Boegh, E.; Olsen, M.

    2014-01-01

    Physical habitat is important in determining the carrying capacity of juvenile brown trout, and within freshwater management. Summer daytime physical habitat selection for the parr lifestage (7-20 cm) juvenile brown trout (Salmo trutta) was assessed in 6 small lowland streams. Habitat preference...... was determined for the four variables; water velocity, water depth, substrate and cover, and the preferences for physical habitat selection were expressed in terms of habitat suitability indices (HSI's). The statistical confidence of HSI's was evaluated using power analysis. It was found that a minimum of 22...... fish observations was needed to have statistical confidence in the HSIs for water depth, and a minimum of 92 fish observations for water velocity during daytime summer conditions. Generally parr were utilising the deeper habitats, indicating preference for deeper water. Cover was also being selected...

  11. Diel resource partitioning among juvenile Atlantic Salmon, Brown Trout, and Rainbow Trout during summer

    Science.gov (United States)

    Johnson, James H.; McKenna, James E.

    2015-01-01

    Interspecific partitioning of food and habitat resources has been widely studied in stream salmonids. Most studies have examined resource partitioning between two native species or between a native species and one that has been introduced. In this study we examine the diel feeding ecology and habitat use of three species of juvenile salmonids (i.e., Atlantic Salmon Salmo salar, Brown Trout Salmo trutta, and Rainbow Trout Oncorhynchus mykiss) in a tributary of Skaneateles Lake, New York. Subyearling Brown Trout and Rainbow Trout fed more heavily from the drift than the benthos, whereas subyearling Atlantic Salmon fed more from the benthos than either species of trout. Feeding activity of Atlantic Salmon and Rainbow Trout was similar, with both species increasing feeding at dusk, whereas Brown Trout had no discernable feeding peak or trough. Habitat availability was important in determining site-specific habitat use by juvenile salmonids. Habitat selection was greater during the day than at night. The intrastream, diel, intraspecific, and interspecific variation we observed in salmonid habitat use in Grout Brook illustrates the difficulty of acquiring habitat use information for widespread management applications.

  12. Effects of turbidity on predation vulnerability of juvenile humpback chub to rainbow and brown trout

    Science.gov (United States)

    Ward, David L.; Morton-Starner, Rylan; Vaage, Benjamin M.

    2016-01-01

    Predation on juvenile native fish by introduced rainbow trout Oncorhynchus mykiss and brown trout Salmo trutta is considered a significant threat to the persistence of endangered humpback chub Gila cypha in the Colorado River in Grand Canyon. Diet studies of rainbow and brown trout in Glen and Grand canyons indicate that these species eat native fish, but impacts are difficult to assess because predation vulnerability is highly variable depending on the physical conditions under which the predation interactions take place. We conducted laboratory experiments to evaluate how short-term predation vulnerability of juvenile humpback chub changes in response to changes in turbidity. In overnight laboratory trials, we exposed hatchery-reared juvenile humpback chub and bonytail Gila elegans (a surrogate for humpback chub) to adult rainbow and brown trout at turbidities ranging from 0 to 1,000 formazin nephlometric units. We found that turbidity as low as 25 formazin nephlometric units significantly reduced predation vulnerability of bonytail to rainbow trout and led to a 36% mean increase in survival (24–60%, 95% CI) compared to trials conducted in clear water. Predation vulnerability of bonytail to brown trout at 25 formazin nephlometric units also decreased with increasing turbidity and resulted in a 25% increase in survival on average (17–32%, 95% CI). Understanding the effects of predation by trout on endangered humpback chub is important when evaluating management options aimed at preservation of native fishes in Grand Canyon National Park. This research suggests that relatively small changes in turbidity may be sufficient to alter predation dynamics of trout on humpback chub in the mainstem Colorado River and that turbidity manipulation may warrant further investigation as a fisheries management tool.

  13. Testing for multiple invasion routes and source populations for the invasive brown treesnake (Boiga irregularis) on Guam: implications for pest management

    Science.gov (United States)

    Richmond, Jonathan Q.; Wood, Dustin A.; Stanford, James W.; Fisher, Robert N.

    2014-01-01

    The brown treesnake (Boiga irregularis) population on the Pacific island of Guam has reached iconic status as one of the most destructive invasive species of modern times, yet no published works have used genetic data to identify a source population. We used DNA sequence data from multiple genetic markers and coalescent-based phylogenetic methods to place the Guam population within the broader phylogeographic context of B. irregularis across its native range and tested whether patterns of genetic variation on the island are consistent with one or multiple introductions from different source populations. We also modeled a series of demographic scenarios that differed in the effective size and duration of a population bottleneck immediately following the invasion on Guam, and measured the fit of these simulations to the observed data using approximate Bayesian computation. Our results exclude the possibility of serial introductions from different source populations, and instead verify a single origin from the Admiralty Archipelago off the north coast of Papua New Guinea. This finding is consistent with the hypothesis thatB. irregularis was accidentally transported to Guam during military relocation efforts at the end of World War II. Demographic model comparisons suggest that multiple snakes were transported to Guam from the source locality, but that fewer than 10 individuals could be responsible for establishing the population. Our results also provide evidence that low genetic diversity stemming from the founder event has not been a hindrance to the ecological success of B. irregularis on Guam, and at the same time offers a unique ‘genetic opening’ to manage snake density using classical biological approaches.

  14. Social interactions of juvenile brown boobies at sea as observed with animal-borne video cameras.

    Directory of Open Access Journals (Sweden)

    Ken Yoda

    Full Text Available While social interactions play a crucial role on the development of young individuals, those of highly mobile juvenile birds in inaccessible environments are difficult to observe. In this study, we deployed miniaturised video recorders on juvenile brown boobies Sula leucogaster, which had been hand-fed beginning a few days after hatching, to examine how social interactions between tagged juveniles and other birds affected their flight and foraging behaviour. Juveniles flew longer with congeners, especially with adult birds, than solitarily. In addition, approximately 40% of foraging occurred close to aggregations of congeners and other species. Young seabirds voluntarily followed other birds, which may directly enhance their foraging success and improve foraging and flying skills during their developmental stage, or both.

  15. Diel foraging and shelter use of large juvenile brown trout (Salmo trutta) under food satiation

    DEFF Research Database (Denmark)

    Conallin, J.; Jyde, M.; Filrup, K.

    2012-01-01

    The diel partitioning of juvenile brown trout Salmo trutta foraging behaviour is controlled by a number of factors including predation risk, competition, temperature and food availability. The present study uses PIT-tagging and visual observation to asses the use of shelter and foraging behaviour...... of Danish wild juvenile brown trout (13.5-15.6 cm). The experiment was conducted in a fluvarium and the fish were fed to satiation. It was hypothesised that food satiation would promote nocturnal foraging and increase daytime shelter use. Our results showed a significant difference in diel shelter use...... between day and night with a significant increase in shelter use during daytime conditions. Visual observations showed a significant preference for nocturnal feeding. Together with the significantly reduced shelter use during the night, our results support the hypothesis that young stream living trout...

  16. DNA fingerprint similarity between female and juvenile brown-headed cowbirds trapped together

    Science.gov (United States)

    Hahn, D.C.; Fleischer, R.C.

    1995-01-01

    This DNA fingerprinting study investigates whether females of the brood parasite brown-headed cowbird, Molothrus ater, associate with their own juvenile offspring at feeding sites more often than would be expected by chance. Cowbirds lay their eggs in the nests of a variety of host species and, as far as is known, leave them to the care of foster parents. Using baited walk-in funnel traps, 36 adult female-juvenile pairs (or trios) of cowbirds were trapped. Blood samples were collected from these individuals to conduct DNA fingerprinting analyses, calculate similarity indices, and to compare S-values for the 11 comparisons of juveniles and the females with which they were caught with S-values of random pairings of juveniles and the females in adjacent gel lanes with which they were not caught. Overall band-sharing was significantly higher for the individuals trapped together than for the random pairings. These associations between juvenile cowbirds and their mothers could occur as a result of female cowbirds monitoring the development of their young in the nests where they have laid. Alternatively, nestling cowbirds in the nest could become familiar visually and locally with a female parent that is frequently in their territory and could follow her when she departs for feeding grounds. In either case these data suggest that adult cowbirds associate with juveniles, in some cases their own offspring, and that offspring may learn to function as cowbirds in part from this association.

  17. Effects of water temperature and fish size on predation vulnerability of juvenile humpback chub to rainbow trout and brown trout

    Science.gov (United States)

    Ward, David L.; Morton-Starner, Rylan

    2015-01-01

    Predation on juvenile native fish by introduced Rainbow Trout and Brown Trout is considered a significant threat to the persistence of endangered Humpback Chub Gila cypha in the Colorado River in the Grand Canyon. Diet studies of Rainbow Trout and Brown Trout in Glen and Grand canyons indicate that these species do eat native fish, but impacts are difficult to assess because predation vulnerability is highly variable, depending on prey size, predator size, and the water temperatures under which the predation interactions take place. We conducted laboratory experiments to evaluate how short-term predation vulnerability of juvenile native fish changes in response to fish size and water temperature using captivity-reared Humpback Chub, Bonytail, and Roundtail Chub. Juvenile chub 45–90 mm total length (TL) were exposed to adult Rainbow and Brown trouts at 10, 15, and 20°C to measure predation vulnerability as a function of water temperature and fish size. A 1°C increase in water temperature decreased short-term predation vulnerability of Humpback Chub to Rainbow Trout by about 5%, although the relationship is not linear. Brown Trout were highly piscivorous in the laboratory at any size > 220 mm TL and at all water temperatures we tested. Understanding the effects of predation by trout on endangered Humpback Chub is critical in evaluating management options aimed at preserving native fishes in Grand Canyon National Park.

  18. Daytime habitat selection for juvenile parr brown trout (Salmo trutta in small lowland streams

    Directory of Open Access Journals (Sweden)

    Conallin J.

    2014-03-01

    Full Text Available Physical habitat is important in determining the carrying capacity of juvenile brown trout, and within freshwater management. Summer daytime physical habitat selection for the parr lifestage (7–20 cm juvenile brown trout (Salmo trutta was assessed in 6 small lowland streams. Habitat preference was determined for the four variables; water velocity, water depth, substrate and cover, and the preferences for physical habitat selection were expressed in terms of habitat suitability indices (HSI’s. The statistical confidence of HSI’s was evaluated using power analysis. It was found that a minimum of 22 fish observations was needed to have statistical confidence in the HSIs for water depth, and a minimum of 92 fish observations for water velocity during daytime summer conditions. Generally parr were utilising the deeper habitats, indicating preference for deeper water. Cover was also being selected for at all sites, but selection was inconsistent among sites for the variables substrate and velocity. The results indicate that during daytime summer conditions water depth is a significant variable for parr habitat selection in these small lowland streams, with cover also being important. Therefore, daytime refugia may be a critical limiting factor for parr in small lowland streams, and important for stream management actions under the Water Framework Directive.

  19. Aerial Application of Acetaminophen treated Baits for Control of Brown Treesnakes

    Science.gov (United States)

    2016-01-22

    This procedure followed NWRC Analytical Method 96B -Determination of Acetaminophen in Tablets. Brown tree snake and non-target animal carcasses ...274 viii ACRONYM LIST APHIS Animal and Plant Health Inspection Service ATOC Aviation and Training Operations Center...native rodent abundance, and impacts to non-target animals . TECHNOLOGY DESCRIPTION Thawed DNM were treated by inserting an 80 mg acetaminophen

  20. Short-term and long-term effects of transient exogenous cortisol manipulation on oxidative stress in juvenile brown trout

    DEFF Research Database (Denmark)

    Birnie-Gauvin, Kim; Peiman, Kathryn S.; Larsen, Martin Hage

    2017-01-01

    available for physiological functions like defence against oxidative stress. Using brown trout (Salmo trutta), we evaluated the short-term (2 weeks) and long-term (4 months over winter) effects of exogenous cortisol manipulations (versus relevant shams and controls) on the oxidative status of wild juveniles...

  1. Invaded Invaders: Infection of Invasive Brown Treesnakes on Guam by an Exotic Larval Cestode with a Life Cycle Comprised of Non-Native Hosts.

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    Elden T Holldorf

    Full Text Available Multiple host introductions to the same non-native environment have the potential to complete life cycles of parasites incidentally transported with them. Our goal was to identify a recently detected parasitic flatworm in the invasive Brown Treesnake (Boiga irregularis on the remote Pacific island of Guam. We considered possible factors influencing parasite transmission, and tested for correlations between infection status and potential indicators of host fitness. We used genetic data from the parasite and information about the native ranges of other possible non-native hosts to hypothesize how it arrived on Guam and how its life cycle may be currently supported.We identified the parasite by comparing larval morphology and mtDNA sequences with other Pseudophyllid tapeworms. We assessed probability of infection in individual snakes using logistic regression and examined different factors influencing presence of parasites in hosts.We identified the parasite as the pseudophyllid cestode Spirometra erinaceieuropaei, with all sampled worms from multiple snakes sharing a single mtDNA haplotype. Infection appears to be limited to the only freshwater watershed on the island, where infection prevalence was high (77.5%. Larger snakes had a higher probability of being infected, consistent with the chronic nature of such infections. While infection status was positively correlated with body condition, infected snakes tended to have lower intra-peritoneal fat body mass, potentially indicating a negative effect on energy stores.We discovered that B. irregularis inhabiting a small area of forested habitat in a freshwater watershed on Guam are often infected by a novel parasite of Asian origin. While further work is needed, this species of Spirometra, itself a non-native species, likely depends on a suite of recently introduced hosts from different parts of the world to complete the life cycle. This baseline study provides little evidence of any effects on host

  2. Diurnal stream habitat use of juvenile Atlantic salmon, brown trout and rainbow trout in winter

    Science.gov (United States)

    Johnson, J. H.; Douglass, K.A.

    2009-01-01

    The diurnal winter habitat of three species of juvenile salmonids was examined in a tributary of Skaneateles Lake, NY to compare habitat differences among species and to determine if species/age classes were selecting specific habitats. A total of 792 observations were made on the depth, velocity, substrate and cover (amount and type) used by sympatric subyearling Atlantic salmon, subyearling brown trout and subyearling and yearling rainbow trout. Subyearling Atlantic salmon occurred in shallower areas with faster velocities and less cover than the other salmonid groups. Subyearling salmon was also the only group associated with substrate of a size larger than the average size substrate in the study reach during both winters. Subyearling brown trout exhibited a preference for vegetative cover. Compared with available habitat, yearling rainbow trout were the most selective in their habitat use. All salmonid groups were associated with more substrate cover in 2002 under high flow conditions. Differences in the winter habitat use of these salmonid groups have important management implications in terms of both habitat protection and habitat enhancement.

  3. Estrogenic effects of phytoestrogens in brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Nielsen, Louise Marie; Holbech, Henrik; Bjerregaard, Poul

    2010-01-01

    , the potential effect of the waterborne phytoestrogens on endemic fish species is largely unknown. In the present investigation, the estrogenic effect of biochanin A was tested in brown trout through water exposure experiments. Juvenile brown trout of both sexes were exposed to different concentrations...... of biochanin A. In a ten day exposure experiments, NOEC and LOEC for plasma vitellogenin induction in brown trout were found to be 0.8µg biochanin A/L and 1.2µg biochanin A/L, respectively. A six hour pulse experiment resulted in NOEC and LOEC for induction of plasma vitellogenin in brown trout of 48µg...... biochanin A/L and 186µg biochanin A/L, respectively. Investigations of the ability of genistein to induce vitellogenin synthesis in brown trout are ongoing....

  4. Use of sibling relationship reconstruction to complement traditional monitoring in fisheries management and conservation of brown trout.

    Science.gov (United States)

    Ozerov, Mikhail; Jürgenstein, Tauno; Aykanat, Tutku; Vasemägi, Anti

    2015-08-01

    Declining trends in the abundance of many fish urgently call for more efficient and informative monitoring methods that would provide necessary demographic data for the evaluation of existing conservation, restoration, and management actions. We investigated how genetic sibship reconstruction from young-of-the-year brown trout (Salmo trutta L.) juveniles provides valuable, complementary demographic information that allowed us to disentangle the effects of habitat quality and number of breeders on juvenile density. We studied restored (n = 15) and control (n = 15) spawning and nursery habitats in 16 brown trout rivers and streams over 2 consecutive years to evaluate the effectiveness of habitat restoration activities. Similar juvenile densities both in restored and control spawning and nursery grounds were observed. Similarly, no differences in the effective number of breeders, Nb(SA) , were detected between habitats, indicating that brown trout readily used recently restored spawning grounds. Only a weak relationship between the Nb(SA) and juvenile density was observed, suggesting that multiple factors affect juvenile abundance. In some areas, very low estimates of Nb(SA) were found at sites with high juvenile density, indicating that a small number of breeders can produce a high number of progeny in favorable conditions. In other sites, high Nb(SA) estimates were associated with low juvenile density, suggesting low habitat quality or lack of suitable spawning substrate in relation to available breeders. Based on these results, we recommend the incorporation of genetic sibship reconstruction to ongoing and future fish evaluation and monitoring programs to gain novel insights into local demographic and evolutionary processes relevant for fisheries management, habitat restoration, and conservation. © 2015 Society for Conservation Biology.

  5. Oxidative stress and partial migration in brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Birnie-Gauvin, Kim; Peiman, K. S.; Larsen, Martin Hage

    2017-01-01

    of oxidative status in migration biology, particularly in fish. Semi-anadromous brown trout (Salmo trutta, Linnaeus 1758) exhibit partial migration, where some individuals smoltify and migrate to sea, and others become stream residents, providing us with an excellent model to investigate the link between...... oxidative stress and migration. Using the brown trout, we obtained blood samples from juveniles from a coastal stream in Denmark in the fall prior to peak seaward migration which occurs in the spring, and assayed for antioxidant capacity (oxygen radical absorbance capacity) and oxidative stress levels...

  6. The results of nocturnal visual surveys are influenced by lamp properties

    Science.gov (United States)

    Lardner, B.; Savidge, J.A.; Rodda, G.H.; Reed, R.N.; Adams, A.A.Y.

    2009-01-01

    We conducted standardized visual searches at night for brown treesnakes (Boiga irregularis) and geckos, where we alternated between spotlight and floodlight lamps. Floodlights rendered us 25% more snakes and 71% more geckos than did spotlights. We show data on searcher variability and discuss what might affect the relative benefit of different lamp types. ?? 2009 Brill Academic Publishers.

  7. Brown trout and food web interactions in a Minnesota stream

    Science.gov (United States)

    Zimmerman, J.K.H.; Vondracek, B.

    2007-01-01

    1. We examined indirect, community-level interactions in a stream that contained non-native brown trout (Salmo trutta Linnaeus), native brook trout (Salvelinus fontinalis Mitchill) and native slimy sculpin (Cottus cognatus Richardson). Our objectives were to examine benthic invertebrate composition and prey selection of fishes (measured by total invertebrate dry mass, dry mass of individual invertebrate taxa and relative proportion of invertebrate taxa in the benthos and diet) among treatments (no fish, juvenile brook trout alone, juvenile brown trout alone, sculpin with brook trout and sculpin with brown trout). 2. We assigned treatments to 1 m2 enclosures/exclosures placed in riffles in Valley Creek, Minnesota, and conducted six experimental trials. We used three designs of fish densities (addition of trout to a constant number of sculpin with unequal numbers of trout and sculpin; addition of trout to a constant number of sculpin with equal numbers of trout and sculpin; and replacement of half the sculpin with an equal number of trout) to investigate the relative strength of interspecific versus intraspecific interactions. 3. Presence of fish (all three species, alone or in combined-species treatments) was not associated with changes in total dry mass of benthic invertebrates or shifts in relative abundance of benthic invertebrate taxa, regardless of fish density design. 4. Brook trout and sculpin diets did not change when each species was alone compared with treatments of both species together. Likewise, we did not find evidence for shifts in brown trout or sculpin diets when each species was alone or together. 5. We suggest that native brook trout and non-native brown trout fill similar niches in Valley Creek. We did not find evidence that either species had an effect on stream communities, potentially due to high invertebrate productivity in Valley Creek. ?? 2007 Blackwell Publishing Ltd.

  8. Survival and growth rates of juvenile salmonids reared in lowland streams

    Directory of Open Access Journals (Sweden)

    Golski Janusz

    2016-12-01

    Full Text Available The aim of this study was to assess the efficiency of propagating juvenile trout, Salmo trutta L. in small lowland streams and to evaluate the impact of the environmental conditions in the streams on the juvenile fish. Brown trout (Salmo trutta fario and sea trout (Salmo trutta trutta early fry fed under controlled conditions were used to stock third-order lowland streams. During summer, fall, and spring catches, fry were counted, measured, and weighed. The following parameters were calculated using the data collected: fry stocking density (ind. m-2; survival; specific mortality rate (SMR; length range; mean specimen length; body weight; mean body weight; specific growth rate (SGR; body condition (Fulton’s index. The ichthyological studies were accompanied by simultaneous analyses of environmental conditions that were performed monthly, and benthic macroinvertebrates were sampled in spring and fall. No differences were observed in the biological parameters analyzed between sea trout and brown trout. Variability in environmental parameters such as temperature, oxygenation, conductivity, and stream width and depth were associated with differentiation in the biological parameters of the fry. The results clearly indicate that the considerable potential of small lowland streams for the propagation of salmonid juvenile stages is currently underexploited.

  9. An experimental field evaluation of winter carryover effects in semi-anadromous Brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Midwood, Jonathan D.; Larsen, Martin Hage; Boel, Mikkel

    2015-01-01

    For semi-anadromous brown trout, the decision whether or not to smoltify and migrate to the sea is believed to be made at the end of the preceding summer in response to both local environmental conditions and individual physiological status. Stressors experienced during the fall may therefore...... that a fall stressor can reduce overwinter survival of juvenile brown trout, negatively impact growth of individuals that survive, and ultimately result in a reduction in the number of migratory trout. Carryover effects such as those documented here reveal the cryptic manner in which natural and anthropogenic...... influence their propensity to migrate as well as carry over into the winter resulting in mortality when fish face challenging environmental conditions. To evaluate this possibility, we artificially elevated cortisol levels in juvenile trout (via intracoelomic injection of cortisol in the fall) and used...

  10. Juvenile competitive bottleneck in the production of brown trout in hydroelectric reservoirs due to intraspecific habitat segregation

    International Nuclear Information System (INIS)

    Hegge, O.; Hesthagen, T.; Skurdal, J.

    1993-01-01

    Resource utilization and growth of brown trout were studied in four deep (mean depths 16.2 - 37.5 m) Norwegian hydroelectric reservoirs by benthic and pelagic gillnet sampling. In all the reservoirs supplementary stockings are carried out. The brown trout were spatially segregated according to size as the habitat use of small individuals (< 180-220 mm) was completely restricted to benthic habitats, whereas larger individuals mainly utilized the upper strata of pelagic waters. It is argued that the pelagic habitat is the more rewarding, and that small-sized brown trout are forced into the less favourable benthic habitat through social interactions with larger specimens. This is supported by an increase in growth of brown trout from their third to fifth year of life, which seems to be related to the shift from benthic to pelagic behaviour. It is also argued that the conditions for small-sized brown trout may be a bottleneck in the capacity to produce brown trout in hydroelectric reservoirs with limited benthic feeding conditions, despite ample access to food in pelagic habitats. When evaluating the possibility of increasing the yield of brown trout through supplementary stockings, it is therefore important to consider food and growth conditions for all age and size groups of brown trout. In reservoirs with poor benthic feeding conditions it may be necessary to stock with brown trout of sizes that are large enough to utilize pelagic habitat, to avoid the limiting benthic living stage. (Author)

  11. Demographic changes following mechanical removal of exotic brown trout in an Intermountain West (USA), high-elevation stream

    Science.gov (United States)

    Saunders, W. Carl; Budy, Phaedra E.; Thiede, Gary P.

    2015-01-01

    Exotic species present a great threat to native fish conservation; however, eradicating exotics is expensive and often impractical. Mechanical removal can be ineffective for eradication, but nonetheless may increase management effectiveness by identifying portions of a watershed that are strong sources of exotics. We used mechanical removal to understand processes driving exotic brown trout (Salmo trutta) populations in the Logan River, Utah. Our goals were to: (i) evaluate the demographic response of brown trout to mechanical removal, (ii) identify sources of brown trout recruitment at a watershed scale and (iii) evaluate whether mechanical removal can reduce brown trout densities. We removed brown trout from 2 km of the Logan River (4174 fish), and 5.6 km of Right Hand Fork (RHF, 15,245 fish), a low-elevation tributary, using single-pass electrofishing. We compared fish abundance and size distributions prior to, and after 2 years of mechanical removal. In the Logan River, immigration to the removal reach and high natural variability in fish abundances limited the response to mechanical removal. In contrast, mechanical removal in RHF resulted in a strong recruitment pulse, shifting the size distribution towards smaller fish. These results suggest that, before removal, density-dependent mortality or emigration of juvenile fish stabilised adult populations and may have provided a source of juveniles to the main stem. Overall, in sites demonstrating strong density-dependent population regulation, or near sources of exotics, short-term mechanical removal has limited effects on brown trout populations but may help identify factors governing populations and inform large-scale management of exotic species.

  12. If and when: Intrinsic differences and environmental stressors influence migration in brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Peiman, K. S.; Birnie-Gauvin, Kim; Midwood, J. D.

    2017-01-01

    Partial migration is a common phenomenon, yet the causes of individual differences in migratory propensity are not well understood. We examined factors that potentially influence timing of migration and migratory propensity in a wild population of juvenile brown trout (Salmo trutta) by combining...

  13. Potential of using tropical brown macroalgae sargassum cristaefolium meal in the diets for juvenile white shrimp (litopenaeus vannamei)

    Science.gov (United States)

    Sudaryono, A.; Sukardi, P.; Yudiarti, E.; Hardi, E. H.; Hastuti, S.; Susilowati, T.

    2018-04-01

    The objectives of this study were to evaluate the effect of different dietary levels of tropical marine brown macroalgae, Sargassum cristaefolium meal (SCM) on growth performance and feed utilization efficiency of juvenile white shrimp, Litopenaeus vannamei (mean initial weight 2.65±0.1 g). The algae were collected from Bandengan Coast, Jepara, Indonesia. The study used a completely randomized design with 5 treatments of dietary different S. cristaefolium meal levels (0, 10, 20, 30, and 40 g algae meal/kg feed) in triplicates. The results showed that the different levels of dietary SCM did not significantly affect (P>0.05) average daily growth (ADG;.204-224 mg/day) and survival (80-97%) of the shrimp after a 42-day feeding period. However, the test diets significantly affected (P<0.05) feed intake (FI), feed conversion ratio (FCR), and protein efficiency ratio (PER). Better FCR (2.13) and PER (1.34) was found by the diet with 2% SCM compared to the control diet (no SCM) (FCR 3.42 and PER 0.81). This finding indicates that the supplement of dietary 2% SCM (20 g/kg feed) can increase the feed utilization efficiency up to 62% or reduce the FCR up to 38% without any adverse in growth performance.

  14. Uptake of 17β-estradiol and biomarker responses in brown trout (Salmo trutta) exposed to pulses

    International Nuclear Information System (INIS)

    Knudsen, Jacob J.G.; Holbech, Henrik; Madsen, Steffen S.; Bjerregaard, Poul

    2011-01-01

    In streams, chemicals such as 17β-estradiol (E2) are likely to occur in pulses. We investigated uptake and biomarker responses in juvenile brown trout (Salmo trutta) of 3- or 6-h pulses of concentrations up to 370 ng E2 L -1 . Uptake by the fish was estimated from disappearance of E2 from tank water. A single 6-h pulse of 370 ng E2 L -1 increased the plasma vitellogenin concentration, liver Erα- and vitellogenin-mRNA. Exposure to 150-160 ng E2 L -1 for 6 h increased vitellogenin in one experiment but not in another. Two 6-h pulses had a larger effect one pulse. Brown trout in the size range 24-74 g took up E2 linearly with time and exposure concentration with a concentration ratio rate of 20.2 h -1 . In conclusion, the threshold for induction of estrogenic effects in juvenile brown trout at short term pulse exposure appears to be in the range 150-200 ng E2 L -1 . - Highlights: → We investigated estrogenic effects of pulse exposure of 17β-estradiol in brown trout. → We used induction of vitellogenin and gene expression as biomarkers. → The threshold for effects after 6 h pulses ranges between 150 and 200 ng E2 L -1 . → E2 is taken up in ∼50 g fish linearly with time and concentration at 20 h -1 . - The threshold concentration for induction of estrogenic effects in brown trout upon short term (6 h) exposure is in the range 150-200 ng E2 L -1 .

  15. Uptake of 17{beta}-estradiol and biomarker responses in brown trout (Salmo trutta) exposed to pulses

    Energy Technology Data Exchange (ETDEWEB)

    Knudsen, Jacob J.G.; Holbech, Henrik; Madsen, Steffen S. [Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense (Denmark); Bjerregaard, Poul, E-mail: poul@biology.sdu.dk [Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense (Denmark)

    2011-12-15

    In streams, chemicals such as 17{beta}-estradiol (E2) are likely to occur in pulses. We investigated uptake and biomarker responses in juvenile brown trout (Salmo trutta) of 3- or 6-h pulses of concentrations up to 370 ng E2 L{sup -1}. Uptake by the fish was estimated from disappearance of E2 from tank water. A single 6-h pulse of 370 ng E2 L{sup -1} increased the plasma vitellogenin concentration, liver Er{alpha}- and vitellogenin-mRNA. Exposure to 150-160 ng E2 L{sup -1} for 6 h increased vitellogenin in one experiment but not in another. Two 6-h pulses had a larger effect one pulse. Brown trout in the size range 24-74 g took up E2 linearly with time and exposure concentration with a concentration ratio rate of 20.2 h{sup -1}. In conclusion, the threshold for induction of estrogenic effects in juvenile brown trout at short term pulse exposure appears to be in the range 150-200 ng E2 L{sup -1}. - Highlights: > We investigated estrogenic effects of pulse exposure of 17{beta}-estradiol in brown trout. > We used induction of vitellogenin and gene expression as biomarkers. > The threshold for effects after 6 h pulses ranges between 150 and 200 ng E2 L{sup -1}. > E2 is taken up in {approx}50 g fish linearly with time and concentration at 20 h{sup -1}. - The threshold concentration for induction of estrogenic effects in brown trout upon short term (6 h) exposure is in the range 150-200 ng E2 L{sup -1}.

  16. Short-term and long-term effects of transient exogenous cortisol manipulation on oxidative stress in juvenile brown trout.

    Science.gov (United States)

    Birnie-Gauvin, Kim; Peiman, Kathryn S; Larsen, Martin H; Aarestrup, Kim; Willmore, William G; Cooke, Steven J

    2017-05-01

    In the wild, animals are exposed to a growing number of stressors with increasing frequency and intensity, as a result of human activities and human-induced environmental change. To fully understand how wild organisms are affected by stressors, it is crucial to understand the physiology that underlies an organism's response to a stressor. Prolonged levels of elevated glucocorticoids are associated with a state of chronic stress and decreased fitness. Exogenous glucocorticoid manipulation reduces an individual's ability to forage, avoid predators and grow, thereby limiting the resources available for physiological functions like defence against oxidative stress. Using brown trout ( Salmo trutta ), we evaluated the short-term (2 weeks) and long-term (4 months over winter) effects of exogenous cortisol manipulations (versus relevant shams and controls) on the oxidative status of wild juveniles. Cortisol caused an increase in glutathione over a 2 week period and appeared to reduce glutathione over winter. Cortisol treatment did not affect oxidative stress levels or low molecular weight antioxidants. Cortisol caused a significant decrease in growth rates but did not affect predation risk. Over-winter survival in the stream was associated with low levels of oxidative stress and glutathione. Thus, oxidative stress may be a mechanism by which elevated cortisol causes negative physiological effects. © 2017. Published by The Company of Biologists Ltd.

  17. Juvenile Galápagos pelicans increase their foraging success by copying adult behaviour.

    Directory of Open Access Journals (Sweden)

    Henrik Brumm

    Full Text Available Social learning is the building block of culture and traditions in humans and nonhuman animals, and its study has a long history. Most investigations have addressed either the causation or the function of social learning. Though much is known about the underlying mechanisms of social learning, demonstrations of its adaptive value in a natural setting are lacking. Here we show that juvenile brown pelicans (Pelecanus occidentalis can increase their foraging efficiency by copying adult diving behaviour, suggesting that social learning helps juveniles to find profitable food patches. Our findings demonstrate the potential fitness consequences of behavioural copying and thus highlight the possible adaptive importance of social learning.

  18. Estrogenic effect of the phytoestrogen biochanin A in zebrafish, Danio rerio, and brown trout, Salmo trutta.

    Science.gov (United States)

    Holbech, Henrik; Schröder, Kristoffer D; Nielsen, Marie L; Brande-Lavridsen, Nanna; Holbech, Bente Frost; Bjerregaard, Poul

    2013-11-15

    Isoflavones with estrogenic activity produced in Fabaceae plants are known to leach from agricultural areas to freshwater systems, but the effect of waterborne isoflavones in fish has not been thoroughly characterized. Therefore, the estrogenic effect of waterborne biochanin A was investigated in zebrafish (Danio rerio) and juvenile brown trout (Salmo trutta). Exposure of juvenile brown trout to 10 μg biochanin AL(-1) or higher caused marked vitellogenin induction after 9-10 days of exposure and so did exposure to 186 μg biochanin AL(-1) for 6h. Following 8d of exposure, a NOEC for induction of vitellogenin production in male zebrafish was 70 and LOEC 114 μg biochanin AL(-1). Exposure to 209 μg biochanin AL(-1) from hatch to 60 days post hatch (dph) caused a skewing of the sex ratio toward more phenotypic female zebrafish, but did not cause induction of vitellogenin in male and undifferentiated fish. (1) biochanin A elicits estrogenic effects in trout at environmentally realistic concentrations, (2) brown trout plasma vitellogenin concentrations respond to lower biochanin A exposure concentrations than vitellogenin concentrations in zebrafish homogenates and (3) concerning vitellogenin induction, the hypothesis should be tested if short term tests with zebrafish may show a higher sensitivity than partial life cycle tests. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Influence of drought conditions on brown trout biomass and size structure in the Black Hills, South Dakota

    Science.gov (United States)

    James, Daniel A.; Wilhite, Jerry W.; Chipps, Steven R.

    2010-01-01

    We evaluated the influence of drought conditions on the biomass of brown trout Salmo trutta in Spearfish Creek, upper Rapid Creek, and lower Rapid Creek in the Black Hills of western South Dakota. Stream discharge, mean summer water temperature, the biomass of juvenile and adult brown trout, and brown trout size structure were compared between two time periods: early (2000–2002) and late drought (2005–2007). Mean summer water temperatures were similar between the early- and late-drought periods in Spearfish Creek (12.4°C versus 11.5°C), lower Rapid Creek (19.2°C versus 19.3°C), and upper Rapid Creek (9.8°C in both periods). In contrast, mean annual discharge differed significantly between the two time periods in Spearfish Creek (1.95 versus 1.50 m3/s), lower Rapid Creek (2.01 versus 0.94 m3/s), and upper Rapid Creek (1.41 versus 0.84 m3/s). The mean biomass of adult brown trout in all three stream sections was significantly higher in the early-drought than in the late-drought period (238 versus 69 kg/ha in Spearfish Creek, 272 versus 91 kg/ha in lower Rapid Creek, and 159 versus 32 kg/ha in upper Rapid Creek). The biomass of juvenile brown trout was similar (43 versus 23 kg/ha) in Spearfish Creek in the two periods, declined from 136 to 45 kg/ha in lower Rapid Creek, and increased from 14 to 73 kg/ha in upper Rapid Creek. Size structure did not differ between the early- and late-drought periods in lower Rapid and Spearfish creeks, but it did in upper Rapid Creek. In addition to drought conditions, factors such as angler harvest, fish movements, and the nuisance algal species Didymosphenia geminata are discussed as possible contributors to the observed changes in brown trout biomass and size structure in Black Hills streams.

  20. Biotic interactions modify multiple-stressor effects on juvenile brown trout in an experimental stream food web.

    Science.gov (United States)

    Bruder, Andreas; Salis, Romana K; Jones, Peter E; Matthaei, Christoph D

    2017-09-01

    Agricultural land use results in multiple stressors affecting stream ecosystems. Flow reduction due to water abstraction, elevated levels of nutrients and chemical contaminants are common agricultural stressors worldwide. Concurrently, stream ecosystems are also increasingly affected by climate change. Interactions among multiple co-occurring stressors result in biological responses that cannot be predicted from single-stressor effects (i.e. synergisms and antagonisms). At the ecosystem level, multiple-stressor effects can be further modified by biotic interactions (e.g. trophic interactions). We conducted a field experiment using 128 flow-through stream mesocosms to examine the individual and combined effects of water abstraction, nutrient enrichment and elevated levels of the nitrification inhibitor dicyandiamide (DCD) on survival, condition and gut content of juvenile brown trout and on benthic abundance of their invertebrate prey. Flow velocity reduction decreased fish survival (-12% compared to controls) and condition (-8% compared to initial condition), whereas effects of nutrient and DCD additions and interactions among these stressors were not significant. Negative effects of flow velocity reduction on fish survival and condition were consistent with effects on fish gut content (-25% compared to controls) and abundance of dominant invertebrate prey (-30% compared to controls), suggesting a negative metabolic balance driving fish mortality and condition decline, which was confirmed by structural equation modelling. Fish mortality under reduced flow velocity increased as maximal daily water temperatures approached the upper limit of their tolerance range, reflecting synergistic interactions between these stressors. Our study highlights the importance of indirect stressor effects such as those transferred through trophic interactions, which need to be considered when assessing and managing fish populations and stream food webs in multiple-stressor situations

  1. The areal extent of brown shrimp habitat suitability in Mobile Bay, Alabama, USA: Targeting vegetated habitat restoration

    Science.gov (United States)

    Smith, L.M.; Nestlerode, J.A.; Harwell, L.C.; Bourgeois, P.

    2010-01-01

    The availability of wetlands and shallow water habitats significantly influences Gulf of Mexico (GOM) penaeid shrimp fishery productivity. However, the GOM region has the highest rate of wetland loss in the USA. Protection and management of these vital GOM habitats are critical to sustainable shrimp fisheries. Brown shrimp (Farfantepenaeus aztecus) are a major component of GOM fisheries. We present an approach for estimating the areal extent of suitable habitat for post-larval and juvenile brown shrimp in Mobile Bay, Alabama, using an existing habitat suitability index model for the northern GOM calculated from probabilistic survey of water quality and sediment data, land cover data, and submerged aquatic vegetation coverages. This estuarine scale approach is intended to support targeted protection and restoration of these habitats. These analyses indicate that approximately 60% of the area of Mobile Bay is categorized as suitable to near optimal for post-larval and juvenile shrimp and 38% of the area is marginally to minimally suitable. We identify potential units within Mobile Bay for targeted restoration to improve habitat suitability. ?? 2010 Springer Science+Business Media B.V.

  2. EVALUATION OF HEMATOLOGY AND BIOCHEMICAL PARAMETERS OF FREE-LIVING EUROPEAN BROWN HARE

    Directory of Open Access Journals (Sweden)

    Miriam Trusinová

    2012-12-01

    Full Text Available The objective of our study was to determine blood hematological and serum chemistry values for a population of free-living European brown hares and to investigate differences related to age. The European brown hare (Lepus europaeus is a species of hare naturally occurring in northern, central and western parts of Europe and southwestern Asia. The blood samples were collected from 25 hares (15 adults and 10 juveniles shot during regular hunting seasons in 4 hunting grounds located in Danube lowland. Following parameters were analyzed: WBC, LYM, GRA, RBC, HGB, HCT, MCV, MCH, MCHC on blood samples, and glucose, total proteins, urea, bilirubin, cholesterol, Ca, P, Na, K, Cl on serum. WBC count was higher in adults (2.86.109.l-1 than in young hares (2.71.109.l-1. RBC count and HGB concentration were higher in young hares (RBC=8.94.1012.l-1, HGB=184.43 g.l-1 than in adults (RBC=8.38.1012.l-1, HGB=177.59 g.l-1. No significant differences were found in other hematology parameters. Biochemical indicators of age were evaluated and an increased content of glucose in adult individuals was found (a = 9.39 mmol.l-1, j = 8.48 mmol.l-1. The increased level of urea in blood serum was observed as almost significant in juvenile individuals (a = 6.11 mmol.l-1, j = 6.94 mmol.l-1, but also reduction of bilirubin was observed (a = 5.19 mmol.l-1, j = 4.23 mmol.l-1. Other monitored biochemical parameters were fairly balanced. All evaluated hematology and serum chemistry parameters of brown hares were within the physiological range with relatively low differences.

  3. Selective predation by feral cats on a native skink on Guam

    Science.gov (United States)

    Lardner, Björn; Reed, Robert N.; Adams, Amy A. Yackel; Mazurek, M.J.; Hinkle, Thomas J.; Levasseur, Patricia M.; Palmer, Meredith S.; Savidge, Julie A.

    2013-01-01

    Two species of skinks (Fig. 1) occur in a 5-ha plot on Guam where we have been conducting intensive research on Brown Treesnake (Boiga irregularis) population biology for nearly a decade (Rodda et al. 2007). The Pacific Blue-tailed Skink (Emoia caeruleocauda [de Vis 1892]) is native to Guam, whereas the Curious Skink (Carlia ailanpalai Zug 2004) is invasive. On the evening of 27 November 2012, PML and MSP discovered a pile of vomited skinks (Fig. 2) inside the plot (UTM 55P: 269125 m E, 1508930 m N).

  4. Molecular and cellular effects of chemicals disrupting steroidogenesis during early ovarian development of brown trout (Salmo trutta fario).

    Science.gov (United States)

    a Marca Pereira, M L; Eppler, E; Thorpe, K L; Wheeler, J R; Burkhardt-Holm, P

    2014-02-01

    A range of chemicals found in the aquatic environment have the potential to influence endocrine function and affect sexual development by mimicking or antagonizing the effects of hormones, or by altering the synthesis and metabolism of hormones. The aim of this study was to evaluate whether the effects of chemicals interfering with sex hormone synthesis may affect the regulation of early ovarian development via the modulation of sex steroid and insulin-like growth factor (IGF) systems. To this end, ex vivo ovary cultures of juvenile brown trout (Salmo trutta fario) were exposed for 2 days to either 1,4,6-androstatriene-3,17-dione (ATD, a specific aromatase inhibitor), prochloraz (an imidazole fungicide), or tributyltin (TBT, a persistent organic pollutant). Further, juvenile female brown trout were exposed in vivo for 2 days to prochloraz or TBT. The ex vivo and in vivo ovarian gene expression of the aromatase (CYP19), responsible for estrogen production, and of IGF1 and 2 were compared. Moreover, 17β-estradiol (E2) and testosterone (T) production from ex vivo ovary cultures was assessed. Ex vivo exposure to ATD inhibited ovarian E2 synthesis, while T levels accumulated. However, ATD did not affect ex vivo expression of cyp19, igf1, or igf2. Ex vivo exposure to prochloraz inhibited ovarian E2 production, but did not affect T levels. Further prochloraz up-regulated igf1 expression in both ex vivo and in vivo exposures. TBT exposure did not modify ex vivo synthesis of either E2 or T. However, in vivo exposure to TBT down-regulated igf2 expression. The results indicate that ovarian inhibition of E2 production in juvenile brown trout might not directly affect cyp19 and igf gene expression. Thus, we suggest that the test chemicals may interfere with both sex steroid and IGF systems in an independent manner, and based on published literature, potentially lead to endocrine dysfunction and altered sexual development. Copyright © 2011 Wiley Periodicals, Inc., A Wiley

  5. The Influence of Fisheries Management on the Brown Trout Population in Moravice River

    Directory of Open Access Journals (Sweden)

    Petr Chalupa

    2016-01-01

    Full Text Available In 2013, an ichthyological investigation with focus on the population of brown trout (Salmo trutta m. fario in Moravice River above Slezská Harta dam reservoir in 6 localities of two salmonid fisheries was conducted (3 locations in fishery Moravice 7 and 3 locations in fishery Moravice 8. Ichthyological investigation in 2013 found abundance of brown trout in fishery Moravice 7 1,621 pcs/ha, in fishery Moravice 8 668 pcs/ha. These results were compared with the results of ichthyological investigations from 2004 (Spurný et al. 2006 and 2012 (unpublished data that were conducted in the same locations of salmonid fisheries of Moravice 7 and Moravice 8. Over 10 years the size structure of brown trout population has changed, which was shown as higher proportion of juvenile fish in size (TL to 15 cm. The average abundance of brown trout with TL up to 15 cm reached in fishery Moravice 7 in 2004 15 pcs/ha (Spurný et al. 2006, in 2013 1,039 pcs/ha, in fishery Moravice 8 in 2004 719 pcs/ha and in 2012 2,234 pcs/ha. Change in size structure of population of brown trout in monitored localities between 2004, 2012 and 2013 was evaluated as statistically significant (d. f. 10; F = 12.8; P < 0.05. Ichthyologic investigations in 2004 (Spurný et al. 2006, 2012 (unpublished data and 2013 determined also abundance of brown trout in fishing size (TL over 25 cm: 54 pcs/ha in 2004 (Spurný et al. 2006, in 2012 (unpublished data 41 pcs/ha, and in 2013 56 pcs/ha. These values were compared with catches of anglers, and according to the results we can say that the fishing pressure had no effect on the abundance of brown trout in fishing size. Abundance of brown trout in salmonid fisheries Moravice 7 and Moravice 8 is probably affected by drought and occurrence of piscivorous predators.

  6. Identifying causes for population decline of the brown hare in agricultural landscapes in Denmark

    DEFF Research Database (Denmark)

    Jensen, Trine-Lee Wincentz

    In recent decades the brown hare (Lepus europaeus) population in Denmark has undergone a substantial decline, but proximate causes are unknown and little is known about actual densities. In this thesis, hare populations are investigated with respect to age composition and reproductive parameters...... proportions in game bags have dropped significantly since the 1950ies. Simple matrix population models with variable juvenile recruitment predict the similar population growth rates as actually observed in the annual bag records. The model substantiates the supposition that declines in the Danish hare...

  7. Juvenile angiofibroma

    Science.gov (United States)

    Nasal tumor; Angiofibroma - juvenile; Benign nasal tumor; Juvenile nasal angiofibroma; JNA ... Juvenile angiofibroma is not very common. It is most often found in adolescent boys. The tumor contains many blood ...

  8. Encystment of parasitic freshwater pearl mussel (Margaritifera margaritifera) larvae coincides with increased metabolic rate and haematocrit in juvenile brown trout (Salmo trutta).

    Science.gov (United States)

    Filipsson, Karl; Brijs, Jeroen; Näslund, Joacim; Wengström, Niklas; Adamsson, Marie; Závorka, Libor; Österling, E Martin; Höjesjö, Johan

    2017-04-01

    Gill parasites on fish are likely to negatively influence their host by inhibiting respiration, oxygen transport capacity and overall fitness. The glochidia larvae of the endangered freshwater pearl mussel (FPM, Margaritifera margaritifera (Linnaeus, 1758)) are obligate parasites on the gills of juvenile salmonid fish. We investigated the effects of FPM glochidia encystment on the metabolism and haematology of brown trout (Salmo trutta Linnaeus, 1758). Specifically, we measured whole-animal oxygen uptake rates at rest and following an exhaustive exercise protocol using intermittent flow-through respirometry, as well as haematocrit, in infested and uninfested trout. Glochidia encystment significantly affected whole-animal metabolic rate, as infested trout exhibited higher standard and maximum metabolic rates. Furthermore, glochidia-infested trout also had elevated levels of haematocrit. The combination of an increased metabolism and haematocrit in infested fish indicates that glochidia encystment has a physiological effect on the trout, perhaps as a compensatory response to the potential respiratory stress caused by the glochidia. When relating glochidia load to metabolism and haematocrit, fish with low numbers of encysted glochidia were the ones with particularly elevated metabolism and haematocrit. Standard metabolic rate decreased with substantial glochidia loads towards levels similar to those of uninfested fish. This suggests that initial effects visible at low levels of encystment may be countered by additional physiological effects at high loads, e.g. potential changes in energy utilization, and also that high numbers of glochidia may restrict oxygen uptake by the gills.

  9. Toxicokinetics of tetrabromoethylcyclohexane (TBECH) in juvenile brown trout (Salmo trutta) and effects on plasma sex hormones

    International Nuclear Information System (INIS)

    Gemmill, Bonnie; Pleskach, Kerri; Peters, Lisa; Palace, Vince; Wautier, Kerry; Park, Brad; Darling, Colin; Rosenberg, Bruno; McCrindle, Robert; Tomy, Gregg T.

    2011-01-01

    Technical 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane or tetrabromoethylcyclohexane (TBECH) used primarily as an additive flame retardant in polystyrene foams, contains two diastereoisomers, α- and β- present in equimolar amounts. At temperatures in excess of 125 o C, isomerization to two other isoforms, δ- and γ- is possible. The recent detection of TBECH in the environment and studies suggesting that isomers are androgenic prompted us to examine the toxicokinetics and biochemical effects of one of the isomers, β-, in a controlled laboratory environment. Juvenile brown trout (Salmo trutta) were exposed to three different amounts of the β-isomer (low, medium and high) via the food followed by a period in which they were exposed to unfortified food. A fourth group of fish was exposed to unfortified food for the duration of the experiment. On days 0, 7, 14, 21, 35, 49, 56, 63, 77, 91, 105, and 133, eight fish from each treatment group were euthanized and liver, plasma, lower jaw (i.e., thyroid tissue) and gonad were collected and the remaining tissue ('whole-fish') was retained. β-Isomer content was measured in whole-fish and in liver while estradiol (E2), 11-ketotestosterone (11-KT) and testosterone (T) were measured in plasma. Based on liver and gonad somatic indices, no apparent effects on liver or gonad development in fish from any of the treatment groups were observed. The bioaccumulation of β-isomer was similar in fish from all treatment groups with steady-state occurring before the end of the uptake phase. Depuration of the β-isomer from fish obeyed first order kinetics and there were no statistically significant differences in the depuration half life (t 1/2 ) among the treatment groups: 22.5 ± 10.4 (low), 13.5 ± 5.9 (med) and 13.8 ± 2.2 (high) days. Steady-state biomagnification factors were much smaller than 1 for fish in all treatment groups. Debrominated metabolites were not detected in composite liver or whole-fish extracts and there was no

  10. Toxicokinetics of tetrabromoethylcyclohexane (TBECH) in juvenile brown trout (Salmo trutta) and effects on plasma sex hormones

    Energy Technology Data Exchange (ETDEWEB)

    Gemmill, Bonnie [Fisheries and Oceans Canada, Arctic Aquatic Research Division, Winnipeg, Manitoba R3T 2N6 (Canada); Department of Environment and Geography, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Pleskach, Kerri [Fisheries and Oceans Canada, Arctic Aquatic Research Division, Winnipeg, Manitoba R3T 2N6 (Canada); Peters, Lisa [Fisheries and Oceans Canada, Arctic Aquatic Research Division, Winnipeg, Manitoba R3T 2N6 (Canada); Department of Environment and Geography, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Palace, Vince [Department of Environment and Geography, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Fisheries and Oceans Canada, Environmental Science Division, Winnipeg, Manitoba R3T 2N6 (Canada); Wautier, Kerry; Park, Brad [Fisheries and Oceans Canada, Environmental Science Division, Winnipeg, Manitoba R3T 2N6 (Canada); Darling, Colin; Rosenberg, Bruno [Fisheries and Oceans Canada, Arctic Aquatic Research Division, Winnipeg, Manitoba R3T 2N6 (Canada); McCrindle, Robert [Wellington Laboratories Incorporated, Research Division, Guelph, ON N1G 3M5 (Canada); Tomy, Gregg T., E-mail: gregg.tomy@dfo-mpo.gc.ca [Fisheries and Oceans Canada, Arctic Aquatic Research Division, Winnipeg, Manitoba R3T 2N6 (Canada); Department of Environment and Geography, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada)

    2011-01-25

    Technical 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane or tetrabromoethylcyclohexane (TBECH) used primarily as an additive flame retardant in polystyrene foams, contains two diastereoisomers, {alpha}- and {beta}- present in equimolar amounts. At temperatures in excess of 125 {sup o}C, isomerization to two other isoforms, {delta}- and {gamma}- is possible. The recent detection of TBECH in the environment and studies suggesting that isomers are androgenic prompted us to examine the toxicokinetics and biochemical effects of one of the isomers, {beta}-, in a controlled laboratory environment. Juvenile brown trout (Salmo trutta) were exposed to three different amounts of the {beta}-isomer (low, medium and high) via the food followed by a period in which they were exposed to unfortified food. A fourth group of fish was exposed to unfortified food for the duration of the experiment. On days 0, 7, 14, 21, 35, 49, 56, 63, 77, 91, 105, and 133, eight fish from each treatment group were euthanized and liver, plasma, lower jaw (i.e., thyroid tissue) and gonad were collected and the remaining tissue ('whole-fish') was retained. {beta}-Isomer content was measured in whole-fish and in liver while estradiol (E2), 11-ketotestosterone (11-KT) and testosterone (T) were measured in plasma. Based on liver and gonad somatic indices, no apparent effects on liver or gonad development in fish from any of the treatment groups were observed. The bioaccumulation of {beta}-isomer was similar in fish from all treatment groups with steady-state occurring before the end of the uptake phase. Depuration of the {beta}-isomer from fish obeyed first order kinetics and there were no statistically significant differences in the depuration half life (t{sub 1/2}) among the treatment groups: 22.5 {+-} 10.4 (low), 13.5 {+-} 5.9 (med) and 13.8 {+-} 2.2 (high) days. Steady-state biomagnification factors were much smaller than 1 for fish in all treatment groups. Debrominated metabolites were not

  11. Effect of natural and laboratory diet on O : N ratio in juvenile lobsters (Homarus americanus).

    Science.gov (United States)

    Brown, Anne Christine

    2006-05-01

    Oxygen consumption and ammonia excretion rates of juvenile lobsters spanning the size range from shelter-restricted to vagile (7-60 mm CL, carapace length) were measured. There are no significant size-dependent break points in the slope of oxygen consumption or nitrogen excretion rates versus weight in freshly caught wild or laboratory fed lobsters. This suggests that there are no inherent changes in energy metabolism in juvenile lobster in the 7-60 mm CL range (stage V to adolescent lobsters), despite major behavioral shifts related to foraging and shelter use. In addition, the O : N ratio of freshly caught wild lobsters (15.7+/-7.4, mean+/-S.D.) is not significantly different from that of lobsters fed brown algae (13.4+/-4.9) or a mixed carbohydrate/protein diet (13.7+/-6.8) in lab. The O : N ratio of wild lobsters is significantly higher than lobsters fed a high protein diet (7.5+/-2.5) in the lab. This suggests that carbohydrates, particularly algal-derived carbohydrates, make up a significant portion of the metabolic fuel of wild juvenile lobsters from settlement through adolescence.

  12. A Voxel Based Morphometry Study of Brain Gray Matter Volumes in Juvenile Obsessive Compulsive Disorder.

    Science.gov (United States)

    Jayarajan, Rajan Nishanth; Agarwal, Sri Mahavir; Viswanath, Biju; Kalmady, Sunil V; Venkatasubramanian, Ganesan; Srinath, Shoba; Chandrashekar, C R; Janardhan Reddy, Y C

    2015-01-01

    Adult patients with Obsessive Compulsive Disorder (OCD) have been shown to have gray matter (GM) volume differences from healthy controls in multiple regions - the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), medial frontal gyri (MFG), striatum, thalamus, and superior parietal lobule. However, there is paucity of data with regard to juvenile OCD. Hence, we examined GM volume differences between juvenile OCD patients and matched healthy controls using voxel based morphometry (VBM) with the above apriori regions of interest. Fifteen right handed juvenile patients with OCD and age- sex- handedness- matched healthy controls were recruited after administering the Mini International Neuropsychiatric Interview-KID and the Children's Yale-Brown Obsessive Compulsive Scale, and scanned using a 3 Tesla magnetic resonance imaging scanner. VBM methodology was followed. In comparison with healthy controls, patients had significantly smaller GM volumes in left ACC. YBOCS total score (current) showed significant negative correlation with GM volumes in bilateral OFC, and left superior parietal lobule. These findings while reiterating the important role of the orbito-fronto-striatal circuitry, also implicate in the parietal lobe - especially the superior parietal lobule as an important structure involved in the pathogenesis of OCD.

  13. Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

    Directory of Open Access Journals (Sweden)

    So Hun Kim

    2016-01-01

    Full Text Available Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

  14. Proliferative kidney disease (PKD) agent Tetracapsuloides bryosalmonae in brown trout populations in Estonia.

    Science.gov (United States)

    Dash, Megha; Vasemägi, Anti

    2014-05-13

    Proliferative kidney disease (PKD) caused by the myxozoan parasite Tetracapsuloides bryosalmonae is a serious parasitic disease threatening both farmed and wild salmonid populations, but very little is currently known about the distribution of the parasite in the Baltic Sea region. In this study we (1) report the development of a novel multiplex PCR method for fast and reliable screening of T. bryosalmonae; (2) use this multiplex PCR method to show that the PKD agent T. bryosalmonae is widespread in natural brown trout Salmo trutta L. populations in Estonia; (3) evaluate monthly and yearly variation of T. bryosalmonae prevalence in juvenile trout; (4) assess T. bryosalmonae prevalence in different age-classes of fish (0+ vs. 1+ and older) and report the presence of the PKD agent in the kidneys of returning sea trout spawners; and (5) suggest the freshwater bryozoan Plumatella fungosa as a putative invertebrate host of T. bryosalmonae in Estonia. Our results demonstrate a highly heterogeneous distribution of T. bryosalmonae at the micro-geographic scale, indicating that PKD could have an important negative effect on recruitment in Estonian brown trout populations.

  15. Juvenile rheumatoid arthritis

    Science.gov (United States)

    ... joints. This form of JIA may turn into rheumatoid arthritis. It may involve 5 or more large and ... no known prevention for JIA. Alternative Names Juvenile rheumatoid arthritis (JRA); Juvenile chronic polyarthritis; Still disease; Juvenile spondyloarthritis ...

  16. An experimental field evaluation of winter carryover effects in semi-anadromous brown trout (Salmo trutta).

    Science.gov (United States)

    Midwood, Jonathan D; Larsen, Martin H; Boel, Mikkel; Aarestrup, Kim; Cooke, Steven J

    2015-11-01

    For semi-anadromous brown trout, the decision whether or not to smoltify and migrate to the sea is believed to be made at the end of the preceding summer in response to both local environmental conditions and individual physiological status. Stressors experienced during the fall may therefore influence their propensity to migrate as well as carry over into the winter resulting in mortality when fish face challenging environmental conditions. To evaluate this possibility, we artificially elevated cortisol levels in juvenile trout (via intracoelomic injection of cortisol in the fall) and used passive integrated transponder tags to compare their overwinter and spring survival, growth, and migration success relative to a control group. Results suggest that overwinter mortality is high for individuals in this population regardless of treatment. However, survival rates were 2.5 times lower for cortisol-treated fish and they experienced significantly greater loss in mass. In addition, less than half as many cortisol-treated individuals made it downstream to a stationary antenna over the winter and also during the spring migration compared to the control treatment. These results suggest that a fall stressor can reduce overwinter survival of juvenile brown trout, negatively impact growth of individuals that survive, and ultimately result in a reduction in the number of migratory trout. Carryover effects such as those documented here reveal the cryptic manner in which natural and anthropogenic stressors can influence fish populations. J. Exp. Zool. 323A: 645-654, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  17. Conceptualizing juvenile prostitution as child maltreatment: findings from the National Juvenile Prostitution Study.

    Science.gov (United States)

    Mitchell, Kimberly J; Finkelhor, David; Wolak, Janis

    2010-02-01

    Two studies were conducted to identify the incidence (Study 1) and characteristics (Study 2) of juvenile prostitution cases known to law enforcement agencies in the United States. Study 1 revealed a national estimate of 1,450 arrests or detentions (95% confidence interval [CI]: 1,287-1,614) in cases involving juvenile prostitution during a 1-year period. In Study 2, exploratory data were collected from a subsample of 138 cases from police records in 2005. The cases are broadly categorized into three main types: (a) third-party exploiters, (b) solo prostitution, and (c) conventional child sexual abuse (CSA) with payment. Cases were classified into three initial categories based on police orientation toward the juvenile: (a) juveniles as victims (53%), (b) juveniles as delinquents (31%), and (c) juvenile as both victims and delinquents (16%). When examining the status of the juveniles by case type, the authors found that all the juveniles in CSA with payment cases were treated as victims, 66% in third-party exploiters cases, and 11% in solo cases. Findings indicate law enforcement responses to juvenile prostitution are influential in determining whether such youth are viewed as victims of commercial sexual exploitation or as delinquents.

  18. [Human brown adipose tissue].

    Science.gov (United States)

    Virtanen, Kirsi A; Nuutila, Pirjo

    2015-01-01

    Adult humans have heat-producing and energy-consuming brown adipose tissue in the clavicular region of the neck. There are two types of brown adipose cells, the so-called classic and beige adipose cells. Brown adipose cells produce heat by means of uncoupler protein 1 (UCP1) from fatty acids and sugar. By applying positron emission tomography (PET) measuring the utilization of sugar, the metabolism of brown fat has been shown to multiply in the cold, presumably influencing energy consumption. Active brown fat is most likely present in young adults, persons of normal weight and women, least likely in obese persons.

  19. Juvenile Arthritis

    Science.gov (United States)

    Juvenile arthritis (JA) is arthritis that happens in children. It causes joint swelling, pain, stiffness, and loss of motion. It can affect any joint, but ... of JA that children get is juvenile idiopathic arthritis. There are several other forms of arthritis affecting ...

  20. Among-sibling differences in the phenotypes of juvenile fish depend on their location within the egg mass and maternal dominance rank

    Science.gov (United States)

    Burton, Tim; Hoogenboom, M. O.; Beevers, N. D.; Armstrong, J. D.; Metcalfe, N. B.

    2013-01-01

    We investigated whether among-sibling differences in the phenotypes of juvenile fish were systematically related to the position in the egg mass where each individual developed during oogenesis. We sampled eggs from the front, middle and rear thirds of the egg mass in female brown trout of known dominance rank. In the resulting juveniles, we then measured traits that are related to individual fitness: body size, social status and standard metabolic rate (SMR). When controlling for differences among females in mean egg size, siblings from dominant mothers were initially larger (and had a lower mass-corrected SMR) if they developed from eggs at the rear of the egg mass. However, heterogeneity in the size of siblings from different positions in the egg mass diminished in lower-ranking females. Location of the egg within the egg mass also affected the social dominance of the resulting juvenile fish, although the direction of this effect varied with developmental age. This study provides the first evidence of a systematic basis for among-sibling differences in the phenotypes of offspring in a highly fecund organism. PMID:23193132

  1. What Is Juvenile Arthritis?

    Science.gov (United States)

    ... Initiative Breadcrumb Home Health Topics English Español Juvenile Arthritis Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Juvenile Arthritis Juvenile arthritis is the term used to describe ...

  2. Temporal clumping of prey and coexistence of unequal interferers: experiments on social forager groups of brown trout feeding on invertebrate drift

    DEFF Research Database (Denmark)

    Jonsson, Mikael; Skov, Christian; Koed, Anders

    2008-01-01

    Environmental fluctuations have been proposed to enhance the coexistence of competing phenotypes. Evaluations are here presented on the effects of prey density and short-term temporal clumping of prey availability on the relative foraging success of unequal interferers in social forager groups...... of juvenile brown trout Salmo trutta feeding on drifting invertebrate prey (frozen chironomids). Groups of three trout with established linear dominance hierarchies (dominant, intermediate and subordinate) were subjected to three different total numbers of prey, combined with three different levels...

  3. Hunting promotes sexual conflict in brown bears.

    Science.gov (United States)

    Gosselin, Jacinthe; Leclerc, Martin; Zedrosser, Andreas; Steyaert, Sam M J G; Swenson, Jon E; Pelletier, Fanie

    2017-01-01

    The removal of individuals through hunting can destabilize social structure, potentially affecting population dynamics. Although previous studies have shown that hunting can indirectly reduce juvenile survival through increased sexually selected infanticide (SSI), very little is known about the spatiotemporal effects of male hunting on juvenile survival. Using detailed individual monitoring of a hunted population of brown bears (Ursus arctos) in Sweden (1991-2011), we assessed the spatiotemporal effect of male removal on cub survival. We modelled cub survival before, during and after the mating season. We used three proxies to evaluate spatial and temporal variation in male turnover; distance and timing of the closest male killed and number of males that died around a female's home range centre. Male removal decreased cub survival only during the mating season, as expected in seasonal breeders with SSI. Cub survival increased with distance to the closest male killed within the previous 1·5 years, and it was lower when the closest male killed was removed 1·5 instead of 0·5 year earlier. We did not detect an effect of the number of males killed. Our results support the hypothesis that social restructuring due to hunting can reduce recruitment and suggest that the distribution of the male deaths might be more important than the overall number of males that die. As the removal of individuals through hunting is typically not homogenously distributed across the landscape, spatial heterogeneity in hunting pressure may cause source-sink dynamics, with lower recruitment in areas of high human-induced mortality. © 2016 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society.

  4. Quantile regression of microgeographic variation in population characteristics of an invasive vertebrate predator

    Science.gov (United States)

    Siers, Shane R.; Savidge, Julie A.; Reed, Robert

    2017-01-01

    Localized ecological conditions have the potential to induce variation in population characteristics such as size distributions and body conditions. The ability to generalize the influence of ecological characteristics on such population traits may be particularly meaningful when those traits influence prospects for successful management interventions. To characterize variability in invasive Brown Treesnake population attributes within and among habitat types, we conducted systematic and seasonally-balanced surveys, collecting 100 snakes from each of 18 sites: three replicates within each of six major habitat types comprising 95% of Guam’s geographic expanse. Our study constitutes one of the most comprehensive and controlled samplings of any published snake study. Quantile regression on snake size and body condition indicated significant ecological heterogeneity, with a general trend of relative consistency of size classes and body conditions within and among scrub and Leucaena forest habitat types and more heterogeneity among ravine forest, savanna, and urban residential sites. Larger and more robust snakes were found within some savanna and urban habitat replicates, likely due to relative availability of larger prey. Compared to more homogeneous samples in the wet season, variability in size distributions and body conditions was greater during the dry season. Although there is evidence of habitat influencing Brown Treesnake populations at localized scales (e.g., the higher prevalence of larger snakes—particularly males—in savanna and urban sites), the level of variability among sites within habitat types indicates little ability to make meaningful predictions about these traits at unsampled locations. Seasonal variability within sites and habitats indicates that localized population characterization should include sampling in both wet and dry seasons. Extreme values at single replicates occasionally influenced overall habitat patterns, while pooling

  5. Vertebrate species introductions in the United States and its territories

    Science.gov (United States)

    Witmer, Gary W.; Fuller, Pam L.

    2011-01-01

    At least 1,065 introduced vertebrate species have been introduced in the United States and its territories, including at least 86 mammalian, 127 avian, 179 reptilian/amphibian, and 673 fish species. Examples in each major taxonomic group include domestic cat, small Indian mongoose, red fox, goat, pig, rabbit, rats, house mouse, gray squirrel, nutria, starling, Indian common myna, red-vented bulbul, brown treesnake, red-eared slider, brown trout, tilapia, and grass carp. We briefly review some of these species and the types of damage they cause. We then review the basic types of methods used for control or eradication of each taxonomic group, including physical, chemical, biological, and cultural methods. We discuss some of the challenges in managing these species, including issues with the use of toxicants, land access, public attitudes, and monitoring difficulties. Finally, we list some ongoing research and future research needs, including improved detection methods, improved attractants, improved barriers, improved capture methods, fertility control, and risk assessment methods.

  6. Juvenile Firesetting.

    Science.gov (United States)

    Peters, Brittany; Freeman, Bradley

    2016-01-01

    Juvenile firesetting is a significant cause of morbidity and mortality in the United States. Male gender, substance use, history of maltreatment, interest in fire, and psychiatric illness are commonly reported risk factors. Interventions that have been shown to be effective in juveniles who set fires include cognitive behavior therapy and educational interventions, whereas satiation has not been shown to be an effective intervention. Forensic assessments can assist the legal community in adjudicating youth with effective interventions. Future studies should focus on consistent assessment and outcome measures to create more evidence for directing evaluation and treatment of juvenile firesetters. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus.

    Directory of Open Access Journals (Sweden)

    Beatrice Mao

    Full Text Available For echolocating bats, hearing is essential for survival. Specializations for detecting and processing high frequency sounds are apparent throughout their auditory systems. Recent studies on echolocating mammals have reported evidence of parallel evolution in some hearing-related genes in which distantly related groups of echolocating animals (bats and toothed whales, cluster together in gene trees due to apparent amino acid convergence. However, molecular adaptations can occur not only in coding sequences, but also in the regulation of gene expression. The aim of this study was to examine the expression of hearing-related genes in the inner ear of developing big brown bats, Eptesicus fuscus, during the period in which echolocation vocalizations increase dramatically in frequency. We found that seven genes were significantly upregulated in juveniles relative to adults, and that the expression of four genes through development correlated with estimated age. Compared to available data for mice, it appears that expression of some hearing genes is extended in juvenile bats. These results are consistent with a prolonged growth period required to develop larger cochlea relative to body size, a later maturation of high frequency hearing, and a greater dependence on high frequency hearing in echolocating bats.

  8. Juvenile Court Statistics - 1972.

    Science.gov (United States)

    Office of Youth Development (DHEW), Washington, DC.

    This report is a statistical study of juvenile court cases in 1972. The data demonstrates how the court is frequently utilized in dealing with juvenile delinquency by the police as well as by other community agencies and parents. Excluded from this report are the ordinary traffic cases handled by juvenile court. The data indicate that: (1) in…

  9. Juvenile Court Statistics, 1974.

    Science.gov (United States)

    Corbett, Jacqueline; Vereb, Thomas S.

    This report presents information on juvenile court processing of youth in the U.S. during 1974. It is based on data gathered under the National Juvenile Court Statistical Reporting System. Findings can be summarized as follows: (1) 1,252,700 juvenile delinquency cases, excluding traffic offenses, were handled by courts in the U.S. in 1974; (2) the…

  10. Chemical composition and natural durability of juvenile and mature heartwood of Robinia pseudoacacia L.

    Directory of Open Access Journals (Sweden)

    João V.F Latorraca

    2011-09-01

    Full Text Available The aim of this study was to characterize the properties of juvenile and mature heartwood of Robinia pseudoacacia L. (black locust. The content, the composition, and subcellular localization of heartwood extractives were studied in 14 old-grown trees from forest sites in Germany and Hungary, as well as in 16 younger trees of four clone types. Heartwood extractives (methanol and acetone extraction were analysed by HPLC-chromatography. UV microspectrophotometry was used to localize the extractives in the wood cell walls. The natural durability of juvenile and mature heartwood was analysed according to the European standard EN 350-1. Growth analyses, as well as the chemical analyses, showed that in Robinia the formation of juvenile wood is restricted to the first 10-15 years of cambial growth. In the heartwood high contents of phenolic compounds and flavonoids were present, which were in high concentrations in the cell walls of the axial parenchyma and of the vessels. In the juvenile heartwood, the content of these extractives is significantly lower than in the mature heartwood. In agree, the juvenile heartwood had a lower resistance to decay by Coniophora puteana (brown rot fungus and Coriolus versicolor (white rot fungus compared to the mature.O objetivo deste estudo foi caracterizar as propriedades da região de cerne dos lenhos juvenis e adultos de Robinia pseudoacacia L. O conteúdo, a composição, bem como a localização subcelular dos extrativos foram estudados em 14 árvores de florestas de produção na Alemanha e na Hungria, assim como em 16 árvores de quatro tipos clone. Os extrativos (metanol e acetona extração foram analisados por cromatografia-HPLC. O microespectrofotômetro de ultra violeta foi utilizado para localizar os extrativos nas paredes celulares da madeira. A durabilidade natural do lenho juvenil e adulto foi analisada de acordo com a norma europeia EN 350-1. Análises do incremento, bem como as análises qu

  11. Brown adipocyte function

    DEFF Research Database (Denmark)

    Winther, Sally

    . The first part of this thesis explores this by identifying and investigating two novel kinase regulators of brown adipocyte function. Study 1 demonstrates that spleen tyrosine kinase is a hitherto undescribed regulator of brown adipocyte differentiation and activation. Study 2 identifies glycogen synthase...

  12. THE STUDY OF FEATURES OF GUILT OF JUVENILE OFFENDERS IN THE CONTEXT OF JUVENILE JUSTICE

    Directory of Open Access Journals (Sweden)

    Natalija Vladimirovna Galkina

    2015-08-01

    Full Text Available The article is devoted to the results of empirical studies of the experiences of guilt of juvenile offenders in the context of juvenile justice where a minor appears as the subject of legal relations. Restorative approach of juvenile justice is based on an admission of guilt to the victim. In connection with it, the research of features of the guilt of minors who have committed an offence and the conditions for the development of the subjectivity will enhance understanding of the possibilities of restorative juvenile justice system in the prevention of juvenile delinquency.Thus, the results of empirical research presented in the article are important for determining of the psychological bases of realization of rehabilitation programs in the context of juvenile justice. In particular, the results are important for the organization and conduct of psychological work to overcome the psychological barriers in the behavior of juveniles having inherently maladaptive guilt and destructive psychological defense mechanisms.

  13. Juvenile Justice in Mexico

    Directory of Open Access Journals (Sweden)

    Martha Frías Armenta

    2014-08-01

    Full Text Available The first tribunal in Mexico was established in the central state of San Luis Potosi in 1926. The Law Regarding Social Prevention and Juvenile Delinquency for the Federal District and Mexican territories was promulgated in 1928. In 2005, Article 18 of the Mexican Constitution was modified to establish a comprehensive system (“Sistema Integral de justicia” in Spanish of justice for juveniles between 12 and 18 years old who had committed a crime punishable under criminal law. Its objective was to guarantee juveniles all the due process rights established for adults, in addition to the special ones recognized for minors. The constitutional reform also provides a framework that includes special tribunals as well as alternative justice options for juveniles. With these reforms, institutionalization of minors was to be considered an extreme measure applicable only to felonies and to juveniles older than 14. In 2006, all states within the Mexican federation enacted the “Law of justice for adolescents”. This system, at both the federal and state levels, formalizes a new global paradigm with regard to the triangular relationship between children, the State and the Law. It recognizes that children are also bearers of the inherent human rights recognized for all individuals, instead of simply objects in need of protection. However, despite formally aligning Mexican juvenile justice law with the Convention on the Rights of the Child (CRC, issues of actual substantive rights remained and new ones have appeared. For example, juveniles younger than 14 who have not committed a felony are released from institutions without any rehabilitation or treatment options, and alternative forms of justice were included without evaluating their possibilities of application or their conditions for success. In addition, the economic status of most juvenile detainees continues to be one of the most important determining factors in the administration of justice

  14. Assessing display variability in wild brown anoles Anolis sagrei using a mechanical lizard model

    Directory of Open Access Journals (Sweden)

    Sarah R. PARTAN, Peter OTOVIC, Virginia L. PRICE, Scott E. BROWN

    2011-04-01

    Full Text Available Signals used for species identity ought to be highly stereotyped so as to facilitate immediate recognition by conspecifics. It is surprising therefore to find variability in putative species signature displays. The brown anole Anolis sagrei has a high degree of variability in its signature bobbing display. In this study we collected descriptive data on variability in the temporal structure of wild brown anole bobbing patterns, finding that no two displays analyzed had the same temporal structure, and we also tested whether wild brown anoles prefer the signature display over an alternate display pattern by using mechanical robot playbacks in the field. As a response metric we assessed whether or not the lizards showed social responses (pushup, dewlap extension, or head-nod in response to the robotic presentations. We found that the lizards responded slightly more to the signature than to the alternate pattern, providing support for the idea that despite the variability seen in displays, the signature pattern is meaningful to them. We tested two other independent variables: speed of the display and elevation of the robot during its display, neither of which was significant. Dewlap extensions were given predominantly by adult males and were more likely to be given in the breeding season than the nonbreeding season. Pushups and head-nods were given equally by males and a combined class of females and juveniles, and were not seasonal. Head-nods increased after the robot turned off, suggesting that they may be used in a conversational turn-taking style during communication [Current Zoology 57 (2: 140–152, 2011].

  15. Brown dwarfs as dark galactic halos

    International Nuclear Information System (INIS)

    Adams, F.C.; Walker, T.P.

    1990-01-01

    The possibility that the dark matter in galactic halos can consist of brown dwarf stars is considered. The radiative signature for such halos consisting solely of brown dwarfs is calculated, and the allowed range of brown dwarf masses, the initial mass function (IMF), the stellar properties, and the density distribution of the galactic halo are discussed. The prediction emission from the halo is compared with existing observations. It is found that, for any IMF of brown dwarfs below the deuterium burning limit, brown dwarf halos are consistent with observations. Brown dwarf halos cannot, however, explain the recently observed near-IR background. It is shown that future satellite missions will either detect brown dwarf halos or place tight constraints on the allowed range of the IMF. 30 refs

  16. Juvenile mammary papillomatosis; Papilomatosis juvenil mamaria

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, M.; Jimenez, A. V. [Hospital Reina Sofia. Cordoba (Spain)

    2001-07-01

    Juvenile mammary papillomatosis is a benign proliferative disease of young patients, generally under 30 years of age. The most frequent clinical presentation is the existence of an elastic and mobile lymph node of the breast. Anatomopathologically, it is characterized because it presents ductal epithelial hyperplasia, sometimes with marked atypia, and there are numerous cysts having different sizes among the findings. It has been associated with an increase in the incidence of breast cancer, both in the patient herself as well as her family. We review the literature on the subject and present the mammographic and ultrasonographic findings of a 22 year old woman diagnosed of juvenile mammary papillomatosis. (Author) 12 refs.

  17. Benchmarking Brown Dwarf Models With a Non-irradiated Transiting Brown Dwarf in Praesepe

    Science.gov (United States)

    Beatty, Thomas; Marley, Mark; Line, Michael; Gizis, John

    2018-05-01

    We wish to use 9.4 hours of Spitzer time to observe two eclipses, one each at 3.6um and 4.5um, of the transiting brown dwarf AD 3116b. AD 3116b is a 54.2+/-4.3 MJ, 1.08+/-0.07 RJ object on a 1.98 day orbit about a 3200K M-dwarf. Uniquely, AD 3116 and its host star are both members of Praesepe, a 690+/-60 Myr old open cluster. AD 3116b is thus one of two transiting brown dwarfs for which we have a robust isochronal age that is not dependent upon brown dwarf evolutionary models, and the youngest brown dwarf for which this is the case. Importantly, the flux AD 3116b receives from its host star is only 0.7% of its predicted internal luminosity (Saumon & Marley 2008). This makes AD 3116b the first known transiting brown dwarf that simultaneously has a well-defined age, and that receives a negligible amount of external irradiation, and a unique laboratory to test radius and luminosity predictions from brown dwarf evolutionary models. Our goal is to measure the emission from the brown dwarf. AD 3116b should have large, 25 mmag, eclipse depths in the Spitzer bandpasses, and we expect to measure them with a precision of +/-0.50 mmag at 3.6um and +/-0.54 mmag at 4.5um. This will allow us to make measure AD 3116b?s internal effective temperature to +/-40K. We will also use the upcoming Gaia DR2 parallaxes to measure AD 3116b's absolute IRAC magnitudes and color, and hence determine the cloud properties of the atmosphere. As the only known brown dwarf with an independently measured mass, radius, and age, Spitzer measurements of AD 3116b's luminosity and clouds will provide a critical benchmark for brown dwarf observation and theory.

  18. Juvenile giant fibroadenoma

    Directory of Open Access Journals (Sweden)

    Vipul Yagnik

    2011-07-01

    Full Text Available Fibroadenomas are benign solid tumor associated with aberration of normal lobular development. Juvenile giant fibroadenoma is usually single and >5 cm in size /or >500 gms in weight. Important differential diagnoses are: phyllodes tumor and juvenile gigantomastia. Simple excision is the treatment of choice.

  19. Peroxisome proliferator-activated receptor gamma (PPARγ) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes.

    Science.gov (United States)

    Lopes, Célia; Madureira, Tânia Vieira; Ferreira, Nádia; Pinheiro, Ivone; Castro, L Filipe C; Rocha, Eduardo

    2016-09-01

    Peroxisome proliferator-activated receptor gamma (PPARγ) is a pivotal regulator of lipid and glucose metabolism in vertebrates. Here, we isolated and characterized for the first time the PPARγ gene from brown trout (Salmo trutta f. fario). Hormones have been reported to interfere with the regulatory function of PPARγ in various organisms, albeit with little focus on fish. Thus, primary hepatocytes isolated from juveniles of brown trout were exposed to 1, 10 and 50μM of ethinylestradiol (EE2) or testosterone (T). A significant (3 fold) decrease was obtained in response to 50μM of EE2 and to 10 and 50μM of T (13 and 14 folds), while a 3 fold increase was observed at 1μM of EE2. Therefore, trout PPARγ seems a target for natural/synthetic compounds with estrogenic or androgenic properties and so, we advocate considering PPARγ as another alert sensor gene when assessing the effects of sex-steroid endocrine disruptors. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. European brown hare syndrome virus in free-ranging European brown hares from Argentina

    DEFF Research Database (Denmark)

    Frolich, K.; Kujawski, G.E.J.G.; Rudolph, M.

    2003-01-01

    From 1998 to 2000, serum samples of 80 shot European brown hares (Lepus europaeus) from Argentina were examined for antibodies against European brown hare syndrome virus (EBHSV) and 80 spleen samples were tested for EBHSV-antigen by enzyme linked immunosorbent assay (ELISA). Nine hares were posit...... in these hares. This is the first report of antibodies to EBHSV, EBHSV-antigen, and electron microscopy findings in free-ranging European brown hares from South America....

  1. 7 CFR 29.3505 - Brown colors.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Brown colors. 29.3505 Section 29.3505 Agriculture... Type 95) § 29.3505 Brown colors. A group of colors ranging from a light brown to a dark brown. These colors vary from medium to low saturation and from medium to very low brillance. As used in these...

  2. 7 CFR 29.2504 - Brown colors.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Brown colors. 29.2504 Section 29.2504 Agriculture...-Cured Tobacco (u.s. Types 22, 23, and Foreign Type 96) § 29.2504 Brown colors. A group of colors ranging from a reddish brown to yellowish brown. These colors vary from low to medium saturation and from very...

  3. Novel nuances of human brown fat

    DEFF Research Database (Denmark)

    Scheele, Camilla; Larsen, Therese Juhlin; Nielsen, Søren

    2014-01-01

    the types of thermogenic adipocytes in humans. We recently published a contradictory mRNA expression signature of human supraclavicular fat defined by an upregulation of the brite marker TBX1 along with the classical brown markers ZIC1 and LHX8, as well as genes indicating brown fat activity including UCP1......, there was no difference in UCP1, PGC-1α, PRDM16, suggesting both depots had equal brown fat potency. Taken together, supraclavicular brown fat derived from adult humans seems to represent a type of brown fat with distinct features from both subcutaneous white/brite and interscapular brown fat. Therefore......There is a current debate in the literature on whether human fat derived from the supraclavicular region should be classified as brown, or as the white fat-derived less potent, brite/beige. This commentary addresses whether the existing classification defined in mice is sufficient to describe...

  4. Juvenile Idiopathic Arthritis

    Directory of Open Access Journals (Sweden)

    Kenan Barut

    2017-04-01

    Full Text Available Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis. Seropositive polyarticular juvenile idiopathic arthritis, an analogue of adult rheumatoid arthritis, is seen in less than 10% of paediatric patients. Seronegative polyarticular juvenile idiopathic arthritis, an entity more specific for childhood, appears with widespread large- and small-joint involvement. Enthesitis-related arthritis is a separate disease subtype, characterized by enthesitis and asymmetric lower-extremity arthritis. This disease subtype represents the childhood form of adult spondyloarthropathies, with human leukocyte antigen-B27 positivity and uveitis but commonly without axial skeleton involvement. Juvenile psoriatic arthritis is characterized by a psoriatic rash, accompanied by arthritis, nail pitting and dactylitis. Disease complications can vary from growth retardation and osteoporosis secondary to treatment and disease activity, to life-threatening macrophage activation syndrome with multi-organ insufficiency. With the advent of new therapeutics over the past 15 years, there has been a marked improvement in juvenile idiopathic arthritis treatment and long-term outcome, without any sequelae. The treatment of juvenile idiopathic arthritis patients involves teamwork, including an experienced paediatric rheumatologist, an ophthalmologist, an orthopaedist, a paediatric psychiatrist and a physiotherapist. The primary goals

  5. Fucoidans from brown seaweeds

    DEFF Research Database (Denmark)

    Ale, Marcel Tutor; Meyer, Anne S.

    2013-01-01

    -proliferative effects on cancer cells. Recent work has revealed distinct structural features of fucoidans obtained from different brown seaweed sources. Fucoidans are classically obtained from brown seaweeds by multi-step, hot acid extraction, but the structural and compositional traits, and possibly the bioactivity......Fucoidan or fucoidans cover a family of sulfated fucose-rich polysaccharides, built of a backbone of L-fucose units, and characteristically found in brown seaweeds. Fucoidans have potential therapeutic properties, including anti-inflammatory and anti-coagulant activities, as well as anti...

  6. Understanding Brown Dwarf Variability

    Science.gov (United States)

    Marley, Mark S.

    2013-01-01

    Surveys of brown dwarf variability continue to find that roughly half of all brown dwarfs are variable. While variability is observed amongst all types of brown dwarfs, amplitudes are typically greatest for L-T transition objects. In my talk I will discuss the possible physical mechanisms that are responsible for the observed variability. I will particularly focus on comparing and contrasting the effects of changes in atmospheric thermal profile and cloud opacity. The two different mechanisms will produce different variability signatures and I will discuss the extent to which the current datasets constrain both mechanisms. By combining constraints from studies of variability with existing spectral and photometric datasets we can begin to construct and test self-consistent models of brown dwarf atmospheres. These models not only aid in the interpretation of existing objects but also inform studies of directly imaged giant planets.

  7. Variability in seroprevalence of rabies virus neutralizing antibodies and associated factors in a Colorado population of big brown bats (Eptesicus fuscus)

    Science.gov (United States)

    O’Shea, Thomas J.; Bowen, Richard A.; Stanley, Thomas R.; Shankar, Vidya; Rupprecht, Charles E.

    2014-01-01

    In 2001–2005 we sampled permanently marked big brown bats (Eptesicus fuscus) at summer roosts in buildings at Fort Collins, Colorado, for rabies virus neutralizing antibodies (RVNA). Seroprevalence was higher in adult females (17.9%, n = 2,332) than males (9.4%, n = 128; P = 0.007) or volant juveniles (10.2%, n = 738; Prabies viral RNA in oropharyngeal secretions of 261 seropositive bats or in organs of 13 euthanized seropositive bats. Survival of seropositive and seronegative bats did not differ. The presence of RVNA in serum of bats should not be interpreted as evidence for ongoing rabies infection.

  8. Intercohort density dependence drives brown trout habitat selection

    Science.gov (United States)

    Ayllón, Daniel; Nicola, Graciela G.; Parra, Irene; Elvira, Benigno; Almodóvar, Ana

    2013-01-01

    Habitat selection can be viewed as an emergent property of the quality and availability of habitat but also of the number of individuals and the way they compete for its use. Consequently, habitat selection can change across years due to fluctuating resources or to changes in population numbers. However, habitat selection predictive models often do not account for ecological dynamics, especially density dependent processes. In stage-structured population, the strength of density dependent interactions between individuals of different age classes can exert a profound influence on population trajectories and evolutionary processes. In this study, we aimed to assess the effects of fluctuating densities of both older and younger competing life stages on the habitat selection patterns (described as univariate and multivariate resource selection functions) of young-of-the-year, juvenile and adult brown trout Salmo trutta. We observed all age classes were selective in habitat choice but changed their selection patterns across years consistently with variations in the densities of older but not of younger age classes. Trout of an age increased selectivity for positions highly selected by older individuals when their density decreased, but this pattern did not hold when the density of younger age classes varied. It suggests that younger individuals are dominated by older ones but can expand their range of selected habitats when density of competitors decreases, while older trout do not seem to consider the density of younger individuals when distributing themselves even though they can negatively affect their final performance. Since these results may entail critical implications for conservation and management practices based on habitat selection models, further research should involve a wider range of river typologies and/or longer time frames to fully understand the patterns of and the mechanisms underlying the operation of density dependence on brown trout habitat

  9. Vertebrate species introductions in the United States and its territories

    Directory of Open Access Journals (Sweden)

    Gary W. WITMER, Pam L. FULLER

    2011-10-01

    Full Text Available At least 1,065 introduced vertebrate species have been introduced in the United States and its territories, including at least 86 mammalian, 127 avian, 179 reptilian/amphibian, and 673 fish species. Examples in each major taxonomic group include domestic cat, small Indian mongoose, red fox, goat, pig, rabbit, rats, house mouse, gray squirrel, nutria, starling, Indian common myna, red-vented bulbul, brown treesnake, red-eared slider, brown trout, tilapia, and grass carp. We briefly review some of these species and the types of damage they cause. We then review the basic types of methods used for control or eradication of each taxonomic group, including physical, chemical, biological, and cultural methods. We discuss some of the challenges in managing these species, including issues with the use of toxicants, land access, public attitudes, and monitoring difficulties. Finally, we list some ongoing research and future research needs, including improved detection methods, improved attractants, improved barriers, improved capture methods, fertility control, and risk assessment methods [Current Zoology 57 (5: 559–567, 2011].

  10. Juvenile angiofibromer

    DEFF Research Database (Denmark)

    Thuesen, Anne Daugaard; Jakobsen, John; Nepper-Rasmussen, Jørgen

    2005-01-01

    Juvenile angiofibroma is a rare, benign, rich vascular tumor, and approximately one new case is diagnosed in Denmark each year. It sits in the foramen sphenopalatinum and occurs in boys from 14 to 25 years of age. The most frequent initial symptoms are nasal obstruction and epistaxis. Through...... the years, the treatment of juvenile angiofibroma has included many methods, including surgical excision, electrocoagulation, interstitial or external radiation therapy, cryosurgery, hormone administration and chemotherapy. Radiation, chemotherapy and surgery have proven to be the most effective treatments...

  11. Purifying and Testing Gecko Skin Compounds, a Promising Attractant for Small Brown Treesnakes

    Science.gov (United States)

    2012-03-13

    and heterocompounds (Si-DCM-MeOH) including fatty acids and sterols (Fig. 12, Table 2). Based on retention times (which were correlated to compound...in Table 2. 23 Fatty acids TMS derivatives Sterols TMS derivatives Cholesterol ‐ TMS Figure 10. GC-MS chromatogram and corresponding mass...That would help circumvent the need for complicated and costly development of synthesis methods. Should cholesterol alone be sufficient, the cost is

  12. Conservation implications of ameliorating survival of little brown bats with white-nose syndrome.

    Science.gov (United States)

    Maslo, Brooke; Valent, Mick; Gumbs, John F; Frick, Winifred F

    2015-10-01

    Management of wildlife populations impacted by novel threats is often challenged by a lack of data on temporal changes in demographic response. Populations may suffer rapid declines from the introduction of new stressors, but how demography changes over time is critical to determining long-term outcomes for populations. White-nose syndrome (WNS), an infectious disease of hibernating bats, has caused massive and rapid population declines in several hibernating species of bats in North America since the disease was first observed on the continent in 2006. Estimating annual survival rates and demographic trends among remnant colonies of hibernating bats that experienced mass mortality from WNS is needed to determine long-term population viability of species impacted by this disease. Using mark-recapture data on infected little brown bats (Myotis lucifugus), we estimated the first apparent annual survival rates for four years following WNS detection at a site. We found strong support for an increasing trend in annual survival, which improved from 0.68 (95% CI = 0.44-0.85) to 0.75 (95% CI = 0.51-0.89) for males and 0.65 (95% CI = 0.44-0.81) to 0.70 (95% CI = 0.50-0.84) for females. These results suggest that stabilization at remnant colonies after mass mortality from WNS may be due to improved survival and not from immigration from other areas. Despite ameliorating survival, our stochastic matrix projection model predicts continued declines for little brown bat populations (λ = 0.95), raising concern for the regional persistence of this species. We conducted a vital rate sensitivity analysis and determined that adult and juvenile survival, as opposed to fecundity, are the demographic parameters most important to target to maximize recovery potential of little brown bat populations in areas impacted by WNS.

  13. Parenting and juvenile delinquency

    NARCIS (Netherlands)

    Hoeve, M.

    2008-01-01

    Juvenile delinquency is a noteworthy problem. This thesis addressed the association between parenting and juvenile delinquency by analyzing the concepts of parenting adopted in family research in relation to criminological concepts and measures of delinquent behavior. Four studies were conducted.

  14. Juvenile delinquency and correctional treatment in Britain

    OpenAIRE

    堀尾, 良弘; ホリオ, ヨシヒロ; Yoshihiro, Horio

    2006-01-01

    Japanese modernistic culture is influenced not a little from Britain. In looking at the Juvenile Law and the history of correctional treatment in Britain, understanding of today's juvenile delinquency and treatment deepen. Moreover, the background and issue of juvenile delinquency in Britain are also discussed. As a feature of the juvenile delinquency in Britain, the common field with Japan and the field peculiar to Britain became clear in each. It is common to the world that the juvenile del...

  15. Juvenile prison in parallel legislation

    Directory of Open Access Journals (Sweden)

    Lutovac Mitar

    2016-01-01

    Full Text Available The need for punishment of juveniles occurred from the time when there was no clear line separating them from the adult criminal population. At the same time, the evolution of the juvenile punishment is not in itself involve substantial changes to their criminal status. On the contrary, the status of minors in society did not show serious differences regarding the status of young adults, as well as the adult elderly. On the other hand, on the ground of their punishment is recorded deviations that go in the direction of application of mild corporal punishment. Closing the minor was performed in a physically separate parts of the general penal institutions with the use of a lower degree of restrictions while serving juvenile prison. Due to the different treatment of minors during the evolution of their criminal status leads to their different treatment in comparative law. That is why we are witnessing the existence of numerous differences in the juvenile punishment in some countries in the world. On the European continent there is a wide range of different legal solutions when it comes to punishing juveniles. There are considerable differences in the procedure pronouncing juvenile prison and in particular penal treatment of juveniles in penitentiary institutions. For these reasons, the author has decided to show the basic statutory provisions in the part that relates to the issue of punishment of minors in the legislation of individual countries.

  16. Brown colour in natural diamond and interaction between the brown related and other colour-inducing defects

    International Nuclear Information System (INIS)

    Fisher, D; Sibley, S J; Kelly, C J

    2009-01-01

    Absorption spectroscopy results on a range of type II diamonds are presented which enable the electronic states associated with them to be mapped out. High pressure, high temperature treatment of brown type IIa diamonds has enabled an activation energy for the removal of the brown colour of 8.0 ± 0.3 eV to be determined and this is consistent with expectations associated with the currently accepted vacancy cluster model for the defect. Theoretical calculations suggest that this defect will generate partially filled gap states about 1 eV above the valence band. Data on the photochromic behaviour of bands producing pink colour and their relation to brown colour are presented; these suggest that the pink bands are produced from two independent transitions with ground states close to each other just below the middle of the band gap. Compensation of neutral boron by charge transfer from states associated with brown colour is demonstrated via the correlated increase in neutral boron and decrease in brown colour on high pressure, high temperature treatment to remove the defects causing the brown colour.

  17. Storage stability of flour-blasted brown rice

    Science.gov (United States)

    Brown rice was blasted with rice flour rather than sand in a sand blaster to make microscopic nicks and cuts so that water can easily penetrate into the brown rice endosperm and cook the rice in a shorter time. The flour-blasted American Basmati brown rice, long grain brown rice, and parboiled long...

  18. 7 CFR 29.2254 - Brown colors.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Brown colors. 29.2254 Section 29.2254 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... colors. A group of colors ranging from a reddish brown to yellowish brown. These colors vary from low to...

  19. Bilateral, independent juvenile nasopharyngeal angiofibroma

    DEFF Research Database (Denmark)

    Mørkenborg, Marie-Louise; Frendø, M; Stavngaard, T

    2015-01-01

    BACKGROUND: Juvenile nasopharyngeal angiofibroma is a benign, vascular tumour that primarily occurs in adolescent males. Despite its benign nature, aggressive growth patterns can cause potential life-threatening complications. Juvenile nasopharyngeal angiofibroma is normally unilateral, originating...... from the sphenopalatine artery, but bilateral symptoms can occur if a large tumour extends to the contralateral side of the nasopharynx. This paper presents the first reported case of true bilateral extensive juvenile nasopharyngeal angiofibroma involving clinically challenging pre-surgical planning...... embolisation. Radical removal performed as one-step, computer-assisted functional endoscopic sinus surgery was performed. The follow-up period was uncomplicated. CONCLUSION: This case illustrates the importance of suspecting bilateral juvenile nasopharyngeal angiofibroma in patients presenting with bilateral...

  20. Criminal Profiles of Violent Juvenile Sex and Violent Juvenile Non-Sex Offenders: An Explorative Longitudinal Study

    Science.gov (United States)

    van Wijk, Anton Ph.; Mali, Bas R. F.; Bullens, Ruud A. R.; Vermeiren, Robert R.

    2007-01-01

    Few studies have longitudinally investigated the criminal profiles of violent juvenile sex and violent juvenile non-sex offenders. To make up for this lack, this study used police records of juveniles to determine the nature of the criminal profiles of violent sex offenders (n = 226) and violent non-sex offenders (n = 4,130). All offenders…

  1. Juvenile morphology in baleen whale phylogeny.

    Science.gov (United States)

    Tsai, Cheng-Hsiu; Fordyce, R Ewan

    2014-09-01

    Phylogenetic reconstructions are sensitive to the influence of ontogeny on morphology. Here, we use foetal/neonatal specimens of known species of living baleen whales (Cetacea: Mysticeti) to show how juvenile morphology of extant species affects phylogenetic placement of the species. In one clade (sei whale, Balaenopteridae), the juvenile is distant from the usual phylogenetic position of adults, but in the other clade (pygmy right whale, Cetotheriidae), the juvenile is close to the adult. Different heterochronic processes at work in the studied species have different influences on juvenile morphology and on phylogenetic placement. This study helps to understand the relationship between evolutionary processes and phylogenetic patterns in baleen whale evolution and, more in general, between phylogeny and ontogeny; likewise, this study provides a proxy how to interpret the phylogeny when fossils that are immature individuals are included. Juvenile individuals in the peramorphic acceleration clades would produce misleading phylogenies, whereas juvenile individuals in the paedomorphic neoteny clades should still provide reliable phylogenetic signals.

  2. Larval, pre-juvenile and juvenile development of Diapterus peruvianus (Perciformes: Gerreidae

    Directory of Open Access Journals (Sweden)

    Sylvia Patricia Adelheid Jiménez Rosenberg

    2003-06-01

    Full Text Available The development of Diapterus peruvianus (Sauvage 1879 is based on 60 larvae collected in superficial tows made in Bahía Concepción, and on 16 prejuvenile and juvenile organisms collected in Bahía de La Paz, B. C. S., México, using a standard plankton net and a rectangular epibenthonic net, respectively. Larvae of D. peruvianus show three large blotches on the dorsum of the gut that can fuse together and give the appearance of one large continuous blotch. There are two to three pre-anal pigments and 16 post-anal pigments in the ventral midline; cephalic pigments are present from the postflexion stage, as well as a serrated preoperculum. The prejuvenile and juvenile organisms are distinguished by their body depth, the analfin formula, the serrated preoperculum and the base pigments in the dorsal and anal fins.El desarrollo de Diapterus peruvianus se analizó con base en 60 larvas recolectadas en Bahía Concepción y 16 pre-juveniles y juveniles recolectados en la Ensenada de La Paz, B. C. S. México, usando respectivamente, una red estándar de plancton en arrastres superficiales y una red epibentónica para arrastres de plancton. Las larvas presentan desde la pre-flexión tres manchas alargadas sobre la superficie dorsal de la masa visceral, que pueden unirse y dar apariencia de pigmentación continua, observándose hasta 16 pigmentos post-anales en la línea media ventral y de dos a tres pigmentos pre-anales; la pigmentación cefálica así como la forma aserrada del pre-opérculo característica del género, aparecen a partir de la post-flexión. Los organismos pre-juveniles y juveniles se distinguen por la profundidad del cuerpo, la fórmula de la aleta anal, la fina forma aserrada del pre-opérculo y la pigmentación en la base de las aletas dorsal y anal.

  3. Natural Inhibitors of Maillard Browning

    Science.gov (United States)

    2013-12-01

    BREAD COLORING CHEESE SPREAD CHEMICAL REACTIONS FLAVOR OXIDATION DAIRY PRODUCTS...nutritional intake, and decrease waste due to non-consumption of sensory degraded ration components. 1.1 Maillard Browning Maillard browning, also

  4. Juvenile Residential Facility Census, 2010: Selected Findings. Juvenile Offenders and Victims: National Report Series. Bulletin NCJ 241134

    Science.gov (United States)

    Hockenberry, Sarah; Sickmund, Melissa; Sladky, Anthony

    2013-01-01

    This bulletin is part of the "Juvenile Offenders and Victims National Report Series." The "National Report" offers a comprehensive statistical overview of the problems of juvenile crime, violence, and victimization and the response of the juvenile justice system. During each interim year, the bulletins in the "National…

  5. Juvenile Confinement in Context

    Science.gov (United States)

    Mendel, Richard A.

    2012-01-01

    For more than a century, the predominant strategy for the treatment and punishment of serious and sometimes not-so-serious juvenile offenders in the United States has been placement into large juvenile corrections institutions, alternatively known as training schools, reformatories, or youth corrections centers. America's heavy reliance on…

  6. Juvenile Angiofibroma: Evolution of Management

    Science.gov (United States)

    Nicolai, Piero; Schreiber, Alberto; Bolzoni Villaret, Andrea

    2012-01-01

    Juvenile angiofibroma is a rare benign lesion originating from the pterygopalatine fossa with distinctive epidemiologic features and growth patterns. The typical patient is an adolescent male with a clinical history of recurrent epistaxis and nasal obstruction. Although the use of nonsurgical therapies is described in the literature, surgery is currently considered the ideal treatment for juvenile angiofibroma. Refinement in preoperative embolization has provided significant reduction of complications and intraoperative bleeding with minimal risk of residual disease. During the last decade, an endoscopic technique has been extensively adopted as a valid alternative to external approaches in the management of small-intermediate size juvenile angiofibromas. Herein, we review the evolution in the management of juvenile angiofibroma with particular reference to recent advances in diagnosis and treatment. PMID:22164185

  7. Juvenile Angiofibroma: Evolution of Management

    Directory of Open Access Journals (Sweden)

    Piero Nicolai

    2012-01-01

    Full Text Available Juvenile angiofibroma is a rare benign lesion originating from the pterygopalatine fossa with distinctive epidemiologic features and growth patterns. The typical patient is an adolescent male with a clinical history of recurrent epistaxis and nasal obstruction. Although the use of nonsurgical therapies is described in the literature, surgery is currently considered the ideal treatment for juvenile angiofibroma. Refinement in preoperative embolization has provided significant reduction of complications and intraoperative bleeding with minimal risk of residual disease. During the last decade, an endoscopic technique has been extensively adopted as a valid alternative to external approaches in the management of small-intermediate size juvenile angiofibromas. Herein, we review the evolution in the management of juvenile angiofibroma with particular reference to recent advances in diagnosis and treatment.

  8. The browning kinetics of the non-enzymatic browning reaction in L-ascorbic acid/basic amino acid systems

    Directory of Open Access Journals (Sweden)

    Ai-Nong YU

    Full Text Available Abstract Under the conditions of weak basis and the reaction temperature range of 110-150 °C, lysine, arginine and histidine were reacted with L-ascorbic acid at equal amount for 30-150 min, respectively and the formation of browning products was monitored with UV–vis spectrometry. The kinetic characteristics of their non-enzymatic browning reaction were investigated. The study results indicated that the non-enzymatic browning reaction of these three amino acids with L-ascorbic acid to form browning products was zero-order reaction. The apparent activation energies for the formation of browning products from L-ascorbic acid/lysine, L-ascorbic acid/arginine and L-ascorbic acid/histidine systems were 54.94, 50.08 and 35.31kJ/mol. The activation energy data indicated the degree of effects of reaction temperature on non-enzymatic browning reaction. Within the temperature range of 110-150 °C, the reaction rate of L-ascorbic acid/lysine system was the fastest one, followed by that of the L-ascorbic acid/arginine system. The reaction rate of L-ascorbic acid/histidine system was the slowest one. Based on the observed kinetic data, the formation mechanisms of browning products were proposed.

  9. Thyroid hormones induce browning of white fat

    Science.gov (United States)

    Martínez-Sánchez, Noelia; Moreno-Navarrete, José M; Contreras, Cristina; Rial-Pensado, Eva; Fernø, Johan; Nogueiras, Rubén; Diéguez, Carlos

    2016-01-01

    The canonical view about the effect of thyroid hormones (THs) on thermogenesis assumes that the hypothalamus acts merely as a modulator of the sympathetic outflow on brown adipose tissue (BAT). Recent data have challenged that vision by demonstrating that THs act on the ventromedial nucleus of the hypothalamus (VMH) to inhibit AMP-activated protein kinase (AMPK), which regulates the thermogenic program in BAT, leading to increased thermogenesis and weight loss. Current data have shown that in addition to activation of brown fat, the browning of white adipose tissue (WAT) might also be an important thermogenic mechanism. However, the possible central effects of THs on the browning of white fat remain unclear. Here, we show that 3,3′,5,5′ tetraiodothyroxyne (T4)-induced hyperthyroidism promotes a marked browning of WAT. Of note, central or VMH-specific administration of 3,3′,5-triiodothyronine (T3) recapitulates that effect. The specific genetic activation of hypothalamic AMPK in the VMH reversed the central effect of T3 on browning. Finally, we also showed that the expression of browning genes in human WAT correlates with serum T4. Overall, these data indicate that THs induce browning of WAT and that this mechanism is mediated via the central effects of THs on energy balance. PMID:27913573

  10. Juvenile polyposis syndrome

    OpenAIRE

    Hsiao, Yi-Han; Wei, Chin-Hung; Chang, Szu-Wen; Chang, Lung; Fu, Yu-Wei; Lee, Hung-Chang; Liu, Hsuan-Liang; Yeung, Chun-Yan

    2016-01-01

    Abstract Background: Juvenile polyposis syndrome, a rare disorder in children, is characterized with multiple hamartomatous polyps in alimentary tract. A variety of manifestations include bleeding, intussusception, or polyp prolapse. In this study, we present an 8-month-old male infant of juvenile polyposis syndrome initially presenting with chronic anemia. To the best of our knowledge, this is the youngest case reported in the literature. Methods: We report a rare case of an 8-month-old male...

  11. Tune Your Brown Clustering, Please

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean; Bøgh, Kenneth Sejdenfaden

    2015-01-01

    Brown clustering, an unsupervised hierarchical clustering technique based on ngram mutual information, has proven useful in many NLP applications. However, most uses of Brown clustering employ the same default configuration; the appropriateness of this configuration has gone predominantly...

  12. Social and psychological aspects of criminal juvenile justice in the world practice (Anglo-Saxon model of juvenile justice

    Directory of Open Access Journals (Sweden)

    D.S. Oshevsky

    2013-10-01

    Full Text Available The article is the final part of the review of existing foreign models of juvenile criminal justice system. We analyze the principles of juvenile justice in the criminal trial: protective orientation, personalization and social richness of the trial, the emphasis on educational influences. We present the foreign experience of incorporating social, psychological and clinical special knowledge into specialized justice concerning juvenile offenders. We analyze modern trends in the development of juvenile justice in the United States and Canada. We present material related to methods of risk assessment of re-offending among adolescents. We highlight approaches to complex long-term follow-up of juvenile offenders in Anglo-Saxon juvenile justice. We describe some aspects of the probation service using the method of case management. In the context of the accepted “National Strategy for Action for the Benefit of Children for 2012-2017”, the prospects for the development of specialized criminal justice for young offenders in the Russian Federation are discussed

  13. Juvenile polyposis syndrome

    Science.gov (United States)

    Hsiao, Yi-Han; Wei, Chin-Hung; Chang, Szu-Wen; Chang, Lung; Fu, Yu-Wei; Lee, Hung-Chang; Liu, Hsuan-Liang; Yeung, Chun-Yan

    2016-01-01

    Abstract Background: Juvenile polyposis syndrome, a rare disorder in children, is characterized with multiple hamartomatous polyps in alimentary tract. A variety of manifestations include bleeding, intussusception, or polyp prolapse. In this study, we present an 8-month-old male infant of juvenile polyposis syndrome initially presenting with chronic anemia. To the best of our knowledge, this is the youngest case reported in the literature. Methods: We report a rare case of an 8-month-old male infant who presented with chronic anemia and gastrointestinal bleeding initially. Panendoscopy and abdominal computed tomography showed multiple polyposis throughout the entire alimentary tract leading to intussusception. Technetium-99m-labeled red blood cell (RBC) bleeding scan revealed the possibility of gastrointestinal tract bleeding in the jejunum. Histopathological examination on biopsy samples showed Peutz-Jeghers syndrome was excluded, whereas the diagnosis of juvenile polyposis syndrome was established. Results: Enteroscopic polypectomy is the mainstay of the treatment. However, polyps recurred and occupied the majority of the gastrointestinal tract in 6 months. Supportive management was given. The patient expired for severe sepsis at the age of 18 months. Conclusion: Juvenile polyposis syndrome is an inherited disease, so it is not possible to prevent it. Concerning of its poor outcome and high mortality rate, it is important that we should increase awareness and education of the parents at its earliest stages. PMID:27631205

  14. Acupuntura em adolescentes com fibromialgia juvenil Acupuntura en adolescentes con fibromialgia juvenil Acupuncture in adolescents with juvenile fibromyalgia

    Directory of Open Access Journals (Sweden)

    Marialda Höfling P. Dias

    2012-01-01

    Full Text Available OBJETIVO: Descrever a utilização da acupuntura em adolescentes com fibromialgia juvenil. MÉTODOS: Estudo retrospectivo realizado em pacientes com fibromialgia juvenil (critérios do Colégio Americano de Reumatologia submetidos a, pelo menos, 11 sessões semanais de acupuntura. As avaliações antes e após acupuntura incluíram dados demográficos, características da dor musculoesquelética, número de pontos dolorosos (NPD, escala visual analógica (EVA de dor, algiometria e índice miálgico (IM. Durante o estudo, os pacientes puderam usar analgésicos, amitriptilina e foram orientados a praticar atividade física aeróbica. Os resultados antes e após acupuntura foram comparados pelo teste não paramétrico de Wilcoxon. RESULTADOS: Dos 38 pacientes com fibromialgia juvenil acompanhados em oito anos consecutivos, 13 tinham todas as informações nos prontuários e nas fichas de acupuntura e foram avaliados. Destes 13, sete obtiveram melhora nos três parâmetros analisados (número de pontos dolorosos, EVA de dor e IM. As medianas do número de pontos dolorosos e da EVA de dor foram significativamente maiores antes do tratamento quando comparados ao final do tratamento com as sessões de acupuntura [14 (11-18 versus 10 (0-15, p=0,005; 6 (2-10 versus 3 (0-10, p=0,045; respectivamente]. Em contraste, a mediana do IM foi significativamente menor antes do tratamento [3,4 (2,49-4,39 versus 4,2 (2,71-5,99, p=0,02]. Nenhum dos pacientes com fibromialgia juvenil apresentou eventos adversos associados à acupuntura. CONCLUSÕES: Acupuntura é uma modalidade de Medicina Tradicional Chinesa que pode ser utilizada nos pacientes pediátricos com fibromialgia. Futuros estudos controlados serão necessários.OBJETIVO: Describir el uso de acupuntura en adolescentes con fibromialgia juvenil. MÉTODOS: Estudio retrospectivo realizado en pacientes con fibromialgia juvenil (criterios del Colegio Americano de Reumatología sometidos a al menos 11 sesiones

  15. Experimental tests for heritable morphological color plasticity in non-native brown trout (Salmo trutta populations.

    Directory of Open Access Journals (Sweden)

    Peter A H Westley

    Full Text Available The success of invasive species is frequently attributed to phenotypic plasticity, which facilitates persistence in novel environments. Here we report on experimental tests to determine whether the intensity of cryptic coloration patterns in a global invader (brown trout, Salmo trutta was primarily the result of plasticity or heritable variation. Juvenile F1 offspring were created through experimental crosses of wild-caught parents and reared for 30 days in the laboratory in a split-brood design on either light or dark-colored gravel substrate. Skin and fin coloration quantified with digital photography and image analysis indicated strong plastic effects in response to substrate color; individuals reared on dark substrate had both darker melanin-based skin color and carotenoid-based fin colors than other members of their population reared on light substrate. Slopes of skin and fin color reaction norms were parallel between environments, which is not consistent with heritable population-level plasticity to substrate color. Similarly, we observed weak differences in population-level color within an environment, again suggesting little genetic control on the intensity of skin and fin colors. Taken as whole, our results are consistent with the hypothesis that phenotypic plasticity may have facilitated the success of brown trout invasions and suggests that plasticity is the most likely explanation for the variation in color intensity observed among these populations in nature.

  16. Juvenile dispersal in Calomys venustus (Muridae: Sigmodontinae)

    Science.gov (United States)

    Priotto, José; Steinmann, Andrea; Provensal, Cecilia; Polop, Jaime

    2004-05-01

    Both spacing behaviour and dispersal movement are viewed as hierarchical processes in which the effects may be expressed at spatial scale. This research was carried out to examine the hypothesis that the presence of parents promotes the dispersal of juveniles from their natal nest and their father or mother home-range, in Calomys venustus.The study was carried out in four 0.25 ha fences (two controls and two experimentals), in a natural pasture. This study had two periods: Father Removal (FR) (August and December 1997; year one) and Mother Removal (MR) (August 1998 and January 1999; year two). For the FR treatment fathers were removed after juveniles were born, but in the MR treatment mothers were removed after the juveniles were weaned. The effect of parents on the dispersal distance of juveniles was analysed with respect to their natal nest and their mother and father home-range. Dispersal distance from the nest of C. venustus was independent of either male or female parent. Juveniles were more dispersing in relation to the centre of activity of their mothers than to that of their fathers, and females were more dispersing than males. Female juveniles overlap their home-range with their parents less than male juveniles do. The differences observed between female and male juveniles would be related to their different sexual maturation times, as well as to the female territoriality.

  17. Essential habitat for sardine juveniles in Iberian waters

    Directory of Open Access Journals (Sweden)

    Sílvia Rodríguez-Climent

    2017-09-01

    Full Text Available In a period when the Iberian sardine stock abundance is at its historical minimum, knowledge of the sardine juvenile’s distribution is crucial for the development of fishery management strategies. Generalized additive models were used to relate juvenile sardine presence with geographical variables and spawning grounds (egg abundance and to model juvenile abundance with the concurrent environmental conditions. Three core areas of juvenile distribution were identified: the Northern Portuguese shelf (centred off Aveiro, the coastal region in the vicinity of the Tagus estuary, and the eastern Gulf of Cadiz. Spatial differences in the relationship between juvenile presence and egg abundances suggest that essential juvenile habitat might partially differ from the prevailing spawning grounds. Models also depicted significant relationships between juvenile abundance, temperature and geographical variables in combination with salinity in the west and with zooplankton in the south. Results indicate that the sardine juvenile distribution along the Iberian Peninsula waters are an outcome of a combination of dynamic processes occurring early in life, such as egg and larva retention, reduced mortality and favourable feeding grounds for both larvae and juveniles.

  18. Juvenile offenders: competence to stand trial.

    Science.gov (United States)

    Soulier, Matthew

    2012-12-01

    This article details the legal background and assists the reader in the preparation and practical conduct of evaluations regarding juvenile adjudicative competency. The material is presented to be useful as a guide to direct questions of competency and covers aspects of evaluation that include: legal standard for competency to stand trial, developmental immaturity, current practice in juvenile competency to stand trial, forensic evaluation of juvenile competency to stand trial, organizing the evaluation, collateral sources of information, psychiatric evaluation of juvenile adjudicative competency, assessment of mental disorder and intellectual disability, assessment of developmental status, assessment of functional abilities for adjudicative competence, and reaching the forensic opinion. Copyright © 2012 Elsevier Inc. All rights reserved.

  19. Parenting and juvenile delinquency

    OpenAIRE

    Hoeve, M.

    2008-01-01

    Juvenile delinquency is a noteworthy problem. This thesis addressed the association between parenting and juvenile delinquency by analyzing the concepts of parenting adopted in family research in relation to criminological concepts and measures of delinquent behavior. Four studies were conducted. The first study addressed a meta-analysis on parenting characteristics and styles in relation to delinquency. In this meta-analysis, previous manuscripts were systematically analyzed, computing mean ...

  20. PSYCHOSOCIAL PROFILE OF JUVENILE DIABETES

    Science.gov (United States)

    Dass, Jyoti; Dhavale, H.S.; Rathi, Anup

    1999-01-01

    A study of the complex relationships between the patient characteristics, family and environmental influences, physician's behaviour and the demands of the disease with its management in Juvenile Diabetics was taken up at a general hospital. 90 subjects were selected for the study and grouped into three. Group A consisted of 30 Juvenile Diabetics, Group B of 30 Adult Diabetics and Group C of 30 Normal healthy adolescents. The impact of the illness was measured on the Diabetes Impact Measurement Scale (DIMS), the behavioural deviations and the parental attitudes towards child rearing on the Fallstrom's Questionnaire (FQ) and the family environment on the Family Climate Scale (FCS). Psychiatric morbidity was assessed using DSM-IV criteria. Group A & B were compared on the DIMS and Group A & C on FQ & FCS. Adult diabetics had a greater impact of diabetes. Juvenile diabetics had significantly higher frequency of behavioural deviations as compared to controls. Also there was a higher number of responses on questions indicating an overprotecting attitude amongst parents of juvenile diabetics. There was an increased incidence of psychiatric morbidity in juvenile diabetics as compared to normal adolescents irrespective of the family environment. The results are discussed in relation to current literature. PMID:21430802

  1. Influence of selected factors on browning of Camembert cheese.

    Science.gov (United States)

    Carreira, Alexandra; Dillinger, Klaus; Eliskases-Lechner, Frieda; Loureiro, Virgílio; Ginzinger, Wolfgang; Rohm, Harald

    2002-05-01

    Experimental Camembert cheeses were made to investigate the effects on browning of the following factors: inoculation with Yarrowia lipolytica, the use of Penicillium candidum strains with different proteolytic activity, the addition of tyrosine, and the addition of Mn2+ thus leading to 16 different variants of cheese. Two physical colour parameters were used to describe browning, depending on the location in the cheeses: a whiteness index for the outside browning (mould mycelium), and a brownness index for the inside browning (surface of the cheese body). Mn2+ promoted a significant increase of browning at both locations, whereas Yar. lipolytica had the opposite effect. Outside browning was significantly more intense when using the Pen. candidum strain with higher proteolytic activity. A significant interaction was found between Yar. lipolytica and Pen. candidum. The yeast had no effect in combination with a low proteolytic strain of Pen. candidum, but significantly reduced proteolysis and browning in combination with a high proteolytic strain of Pen. candidum. We further confirmed that both strains of Pen. candidum were able to produce brown pigments from tyrosine and thus both are presumably responsible for the browning activity in this type of cheese.

  2. Juvenile Prostitution.

    Science.gov (United States)

    Csapo, Marg

    1986-01-01

    Recent research and Canadian government committee reports concerning juvenile prostitution are reviewed. Proposals are made in the realms of law and social policy; and existing programs are described. (DB)

  3. Effects of nonylphenol on key hormonal balances and histopathology of the endangered Caspian brown trout (Salmo trutta caspius).

    Science.gov (United States)

    Shirdel, Iman; Kalbassi, Mohammad Reza

    2016-01-01

    Endocrine disruptor chemicals (EDCs) potentially pose a hazard to endangered species. Evaluation of the sensitivity of these species to EDCs could be helpful for protecting their populations. So, the present study investigated the adverse effects of nonylphenol, an EDC, on the endocrine hormones and histopathology of male and female juvenile Caspian brown trout (Salmo trutta caspius) following 21 days of exposure to nominal concentrations of 1, 10 and 100 μg/l. The results showed that the HSI and plasma total calcium of male and female fishes exposed to 100 μg/l nonylphenol were significantly increased compared with the control groups (P0.05). No significant effect of nonylphenol exposure was observed on male plasma TSH levels (P>0.05), whereas, in females, nonylphenol at all concentrations significantly reduced TSH levels. A bell-shaped response was observed in male and female plasma GH levels. Moreover, various histopathological lesions were observed in gill and intestine tissues of fishes exposed to different nonylphenol concentrations. These results demonstrate the high sensitivity of this endangered species to even environmentally relevant concentrations of nonylphenol. Furthermore, Caspian brown trout could be used as bioindicators reflecting the toxicity of nonylphenol. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Brown coal gasification made easy

    International Nuclear Information System (INIS)

    Hamilton, Chris

    2006-01-01

    Few Victorians will be aware that gas derived from coal was first used in 1849 to provide lighting in a baker's shop in Swanston Street, long before electric lighting came to the State. The first commercial 'gas works' came on stream in 1856 and Melbourne then had street lighting run on gas. By 1892 there were 50 such gas works across the State. Virtually all were fed with black coal imported from New South Wales. Brown coal was first discovered west of Melbourne in 1857, and the Latrobe Valley deposits were identified in the early 1870s. Unfortunately, such wet brown coal did not suit the gas works. Various attempts to commercialise Victorian brown coal met with mixed success as it struggled to compete with imported New South Wales black coal. In June 1924 Yallourn A transmitted the first electric power to Melbourne, and thus began the Latrobe Valley's long association with generating electric power from brown coal. Around 1950, the Metropolitan Gas Company applied for financial assistance to build a towns gas plant using imported German gasification technology which had been originally designed for a brown coal briquette feed. The State Government promptly acquired the company and formed the Gas and Fuel Corporation. The Morwell Gasification Plant was opened on 9 December 1956 and began supplying Melbourne with medium heating value towns gas

  5. Imágenes juveniles, medios y nuevos escenarios

    Directory of Open Access Journals (Sweden)

    Oscar Aguilera Ruiz

    2015-01-01

    Full Text Available Este artículo nace del análisis de los discursos radiales producidos exclusivamente para jóvenes en Santiago de Chile. Aborda además las categorías comprensivas de la vida juvenil, la vida juvenil de los años 90, el imaginario juvenil des-simbolizado, hacia una comprensión de lo juvenil, dinámica social propuesta por los medios y estrategias comunicacionales.

  6. Vegetative propagation of mature and juvenile northern red oak

    Science.gov (United States)

    James J. Zaczek; K. C. Steiner; C. W., Jr. Heuser

    1993-01-01

    Rooting trials were established to evaluate rooting success of cuttings from mature and juvenile, grafted and ungrafted northern red oak (NRO). Buds from 4 mature NRO ortets and juvenile seedlings were grafted onto juvenile and mature rootstock. Cuttings were collected from the grafts and from juvenile and mature shoots developed in situ and...

  7. Antibodies in juvenile-onset myositis.

    Science.gov (United States)

    Tansley, Sarah L

    2016-11-01

    Juvenile-onset myositis is a highly heterogeneous disease. Myositis-specific and associated autoantibodies provide a potential means of subdividing patients into clinically homogenous subgroups. Given the increasing availability of autoantibody testing, this review explores the phenotypes associated with different autoantibodies in juvenile-onset myositis and the potential clinical utility of autoantibody testing. Autoantibodies can be identified in 60-70% of children with myositis and the recent discovery of novel myositis-associated autoantibodies in adult patients suggests this may increase in the near future. Detailed phenotype descriptions are now known for several autoantibodies commonly identified in juvenile-onset disease. Whilst there is insufficient evidence to recommend a differential treatment approach based on autoantibody status, it is becoming increasingly clear that some autoantibody subgroups are often treatment resistant and may benefit from a more aggressive approach. The validation of nonspecialised methods for myositis-specific autoantibody detection should lead to more widely available testing. In juvenile-onset disease, this will provide detailed prognostic information and in the future may also influence approach.

  8. REFORMATIONS IN ZIMBABWE'S JUVENILE JUSTICE SYSTEM

    African Journals Online (AJOL)

    Mugumbate

    1996-05-23

    May 23, 1996 ... The article is based on a desk review of existing literature on juvenile crime in the country. ... that Zimbabwe's juvenile justice system is transforming from being ... recommendations include expanding the Pre-trial Diversion ...

  9. pH preference and avoidance responses of adult brook trout Salvelinus fontinalis and brown trout Salmo trutta.

    Science.gov (United States)

    Fost, B A; Ferreri, C P

    2015-03-01

    The pH preferred and avoided by wild, adult brook trout Salvelinus fontinalis and brown trout Salmo trutta was examined in a series a laboratory tests using gradual and steep-gradient flow-through aquaria. The results were compared with those published for the observed segregation patterns of juvenile S. fontinalis and S. trutta in Pennsylvania streams. The adult S. trutta tested showed a preference for pH 4·0 while adult S. fontinalis did not prefer any pH within the range tested. Salmo trutta are not found in Pennsylvania streams with a base-flow pH < 5·8 which suggests that S. trutta prefer pH well above 4·0. Adult S. trutta displayed a lack of avoidance at pH below 5·0, as also reported earlier for juveniles. The avoidance pH of wild, adult S. fontinalis (between pH 5·5 and 6·0) and S. trutta (between pH 6·5 and 7·0) did not differ appreciably from earlier study results for the avoidance pH of juvenile S. fontinalis and S. trutta. A comparison of c.i. around these avoidance estimates indicates that avoidance pH is similar among adult S. fontinalis and S. trutta in this study. The limited overlap of c.i. for avoidance pH values for the two species, however, suggests that some S. trutta will display avoidance at a higher pH when S. fontinalis will not. The results of this study indicate that segregation patterns of adult S. fontinalis and S. trutta in Pennsylvania streams could be related to pH and that competition with S. trutta could be mediating the occurrence of S. fontinalis at some pH levels. © 2015 The Fisheries Society of the British Isles.

  10. Generalised Brown Clustering and Roll-up Feature Generation

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean

    2016-01-01

    active set size. Moreover, the generalisation permits a novel approach to feature selection from Brown clusters: We show that the standard approach of shearing the Brown clustering output tree at arbitrary bitlengths is lossy and that features should be chosen instead by rolling up Generalised Brown...

  11. Searching for chemical signatures of brown dwarf formation

    Science.gov (United States)

    Maldonado, J.; Villaver, E.

    2017-06-01

    Context. Recent studies have shown that close-in brown dwarfs in the mass range 35-55 MJup are almost depleted as companions to stars, suggesting that objects with masses above and below this gap might have different formation mechanisms. Aims: We aim to test whether stars harbouring massive brown dwarfs and stars with low-mass brown dwarfs show any chemical peculiarity that could be related to different formation processes. Methods: Our methodology is based on the analysis of high-resolution échelle spectra (R 57 000) from 2-3 m class telescopes. We determine the fundamental stellar parameters, as well as individual abundances of C, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, and Zn for a large sample of stars known to have a substellar companion in the brown dwarf regime. The sample is divided into stars hosting massive and low-mass brown dwarfs. Following previous works, a threshold of 42.5 MJup was considered. The metallicity and abundance trends of the two subsamples are compared and set in the context of current models of planetary and brown dwarf formation. Results: Our results confirm that stars with brown dwarf companions do not follow the well-established gas-giant planet metallicity correlation seen in main-sequence planet hosts. Stars harbouring massive brown dwarfs show similar metallicity and abundance distribution as stars without known planets or with low-mass planets. We find a tendency of stars harbouring less-massive brown dwarfs of having slightly higher metallicity, [XFe/Fe] values, and abundances of Sc II, Mn I, and Ni I than the stars having the massive brown dwarfs. The data suggest, as previously reported, that massive and low-mass brown dwarfs might present differences in period and eccentricity. Conclusions: We find evidence of a non-metallicity dependent mechanism for the formation of massive brown dwarfs. Our results agree with a scenario in which massive brown dwarfs are formed as stars. At high metallicities, the core

  12. A Practical Approach to Juvenile Dermatomyositis and Juvenile Scleroderma.

    Science.gov (United States)

    McCann, Liza J; Pain, Clare E

    2016-02-01

    Juvenile dermatomyositis and juvenile scleroderma are rare multisystem autoimmune disorders. Although they share some pathognomonic hallmarks with adult onset myositis or scleroderma, there are significant differences in presentation, characteristics and associated features when the diseases present in childhood. In view of this, and the rarity of the conditions, it is important for care to be led by teams with expertise in pediatric rheumatology conditions. Prognosis has improved significantly in the West; likely due to early diagnosis and aggressive treatment with immunosuppressive medications. However, this trend is not replicated in the developing world. Early recognition of these diseases is crucial to achieve rapid and sustained remission and prevent disease or medication associated complications. This article aims to provide a practical overview for recognition, diagnosis and treatment of these conditions.

  13. Adolescent neglect, juvenile delinquency and the risk of recidivism.

    Science.gov (United States)

    Ryan, Joseph P; Williams, Abigail B; Courtney, Mark E

    2013-03-01

    Victims of child abuse and neglect are at an increased risk of involvement with the juvenile justice and adult correctional systems. Yet, little is known about the continuation and trajectories of offending beyond initial contact with law enforcement. Neglect likely plays a critical role in continued offending as parental monitoring, parental rejection and family relationships are instrumental in explaining juvenile conduct problems. This study sought to determine whether neglect is associated with recidivism for moderate and high risk juvenile offenders in Washington State. Statewide risk assessments and administrative records for child welfare, juvenile justice, and adult corrections were analyzed. The sample was diverse (24 % female, 13 % African American, 8 % Hispanic, 5 % Native American) and included all moderate and high risk juvenile offenders screened by juvenile probation between 2004 and 2007 (n = 19,833). Official records from child protection were used to identify juvenile offenders with a history of child neglect and to identify juvenile offenders with an ongoing case of neglect. Event history models were developed to estimate the risk of subsequent offending. Adolescents with an ongoing case neglect were significantly more likely to continue offending as compared with youth with no official history of neglect. These findings remain even after controlling for a wide range of family, peer, academic, mental health, and substance abuse covariates. Interrupting trajectories of offending is a primary focus of juvenile justice. The findings of the current study indicate that ongoing dependency issues play a critical role in explaining the outcomes achieved for adolescents in juvenile justice settings. The implications for improved collaboration between child welfare and juvenile justice are discussed.

  14. Do juveniles bully more than young offenders?

    Science.gov (United States)

    Ireland, Jane L

    2002-04-01

    This study compares bullying behaviour among juvenile and young offenders and incorporates two different methods to measure bullying. Ninety-five male juvenile and 196 male young offenders completed two questionnaires, one that measured bullying directly and one that measured behaviours indicative of "being bullied" or of "bullying others". Juveniles perceived a higher extent of bullying than young offenders. Juveniles reported significantly more physical, psychological or verbal and overall direct forms of bullying behaviour than young offenders. A number of differences were found between juveniles and young offenders with regard to the types of prisoners likely to become victims, who they would advise a victim to speak to and how bullying could be prevented. The results are discussed in relation to developmental theories of aggression and how bullying behaviour can be defined and measured among prisoners. Copyright 2002 The Association for Professionals in Services for Adolescents. Published by Elsevier Science Ltd. All rights reserved.

  15. An unusual presentation of juvenile lupus nephritis

    Directory of Open Access Journals (Sweden)

    Malleshwar Bottu

    2016-01-01

    Full Text Available The incidence of juvenile lupus varies widely ranging between 4 and 250 per 100,000 population. Most common organ involvement in juvenile lupus is kidney. Neurological, cutaneous and hematological involvements are also involved. Skeletal muscle involvement in the form of myositis is rare. Myositis as presenting manifestation in juvenile lupus is also unusual. Herein, we report one such case wherein myositis preceded the onset of lupus nephritis

  16. L-rhamnose induces browning in 3T3-L1 white adipocytes and activates HIB1B brown adipocytes.

    Science.gov (United States)

    Choi, Minji; Mukherjee, Sulagna; Kang, Nam Hyeon; Barkat, Jameel Lone; Parray, Hilal Ahmad; Yun, Jong Won

    2018-04-11

    Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced browning by elevating expression levels of beige-specific marker genes, including Cd137, Cited1, Tbx1, Prdm16, Tmem26, and Ucp1, in 3T3-L1 adipocytes. Moreover, L-rhamnose markedly elevated expression levels of proteins involved in thermogenesis both in 3T3-L1 white and HIB1B brown adipocytes. L-rhamnose treatment in 3T3-L1 adipocytes also significantly elevated protein levels of p-HSL, p-AMPK, ACOX, and CPT1 as well as reduced levels of ACC, FAS, C/EBPα, and PPARγ, suggesting its possible role in enhancement of lipolysis and lipid catabolism as well as reduced adipogenesis and lipogenesis, respectively. The quick technique of efficient molecular docking provided insight into the strong binding of L-rhamnose to the fat-digesting glycine residue of β 3 -adrenergic receptor (AR), indicating strong involvement of L-rhamnose in fat metabolism. Further examination of the molecular mechanism of L-rhamnose revealed that it induced browning of 3T3-L1 adipocytes via coordination of multiple signaling pathways through β 3 -AR, SIRT1, PKA, and p-38. To the best of our knowledge, this is the first study to demonstrate that L-rhamnose plays multiple modulatory roles in the induction of white fat browning, activation of brown adipocytes, as well as promotion of lipid metabolism, thereby demonstrating its therapeutic potential for treatment of obesity. © 2018 IUBMB Life, 2018. © 2018 International Union of Biochemistry and Molecular Biology.

  17. Laser capture microdissection of gonads from juvenile zebrafish

    DEFF Research Database (Denmark)

    Jørgensen, Anne; Nielsen, John; Morthorst, Jane Ebsen

    2009-01-01

    was adjusted and optimised to isolate juvenile zebrafish gonads. Results: The juvenile zebrafish gonad is not morphologically distinguishable when using dehydrated cryosections on membrane slides and a specific staining method is necessary to identify the gonads. The protocol setup in this study allows......Background: Investigating gonadal gene expression is important in attempting to elucidate the molecular mechanism of sex determination and differentiation in the model species zebrafish. However, the small size of juvenile zebrafish and correspondingly their gonads complicates this type...... of investigation. Furthermore, the lack of a genetic sex marker in juvenile zebrafish prevents pooling gonads from several individuals. The aim of this study was to establish a method to isolate the gonads from individual juvenile zebrafish allowing future investigations of gonadal gene expression during sex...

  18. Extending juvenility in grasses

    Energy Technology Data Exchange (ETDEWEB)

    Kaeppler, Shawn; de Leon Gatti, Natalia; Foerster, Jillian

    2017-04-11

    The present invention relates to compositions and methods for modulating the juvenile to adult developmental growth transition in plants, such as grasses (e.g. maize). In particular, the invention provides methods for enhancing agronomic properties in plants by modulating expression of GRMZM2G362718, GRMZM2G096016, or homologs thereof. Modulation of expression of one or more additional genes which affect juvenile to adult developmental growth transition such as Glossy15 or Cg1, in conjunction with such modulation of expression is also contemplated. Nucleic acid constructs for down-regulation of GRMZM2G362718 and/or GRMZM2G096016 are also contemplated, as are transgenic plants and products produced there from, that demonstrate altered, such as extended juvenile growth, and display associated phenotypes such as enhanced yield, improved digestibility, and increased disease resistance. Plants described herein may be used, for example, as improved forage or feed crops or in biofuel production.

  19. Isolation of glycoproteins from brown algae

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a novel process for the isolation of unique anti-oxidative glycoproteins from the pH precipitated fractions of enzymatic extracts of brown algae. Two brown seaweeds viz, Fucus serratus and Fucus vesiculosus were hydrolysed by using 3 enzymes viz, Alcalase, Viscozyme...

  20. The problem of sampling families rather than populations: Relatedness among individuals in samples of juvenile brown trout Salmo trutta L

    DEFF Research Database (Denmark)

    Hansen, Michael Møller; Eg Nielsen, Einar; Mensberg, Karen-Lise Dons

    1997-01-01

    In species exhibiting a nonrandom distribution of closely related individuals, sampling of a few families may lead to biased estimates of allele frequencies in populations. This problem was studied in two brown trout populations, based on analysis of mtDNA and microsatellites. In both samples mt......DNA haplotype frequencies differed significantly between age classes, and in one sample 17 out of 18 individuals less than 1 year of age shared one particular mtDNA haplotype. Estimates of relatedness showed that these individuals most likely represented only three full-sib families. Older trout exhibiting...

  1. Trustworthy-looking face meets brown eyes.

    Directory of Open Access Journals (Sweden)

    Karel Kleisner

    Full Text Available We tested whether eye color influences perception of trustworthiness. Facial photographs of 40 female and 40 male students were rated for perceived trustworthiness. Eye color had a significant effect, the brown-eyed faces being perceived as more trustworthy than the blue-eyed ones. Geometric morphometrics, however, revealed significant correlations between eye color and face shape. Thus, face shape likewise had a significant effect on perceived trustworthiness but only for male faces, the effect for female faces not being significant. To determine whether perception of trustworthiness was being influenced primarily by eye color or by face shape, we recolored the eyes on the same male facial photos and repeated the test procedure. Eye color now had no effect on perceived trustworthiness. We concluded that although the brown-eyed faces were perceived as more trustworthy than the blue-eyed ones, it was not brown eye color per se that caused the stronger perception of trustworthiness but rather the facial features associated with brown eyes.

  2. Law & psychiatry: punishing juveniles who kill.

    Science.gov (United States)

    Appelbaum, Paul S

    2012-10-01

    Punishment of juvenile murderers forces policy makers to weigh the developmental immaturity of adolescents against the heinousness of their crimes. The U.S. Supreme Court has progressively limited the severity of punishments that can be imposed on juveniles, holding that their impulsivity, susceptibility to peer pressure, and more fluid character render them less culpable for their actions. Having eliminated the death penalty as a punishment, the Court recently struck down mandatory life sentences without prospect of parole. The decision is interesting for its emphasis on rehabilitation, opening the door to further restrictions on punitive sentences for juveniles-and perhaps for adults too.

  3. Síndrome de Brown inflamatória: relato de caso Inflammatory Brown syndrome: case report

    Directory of Open Access Journals (Sweden)

    Leonardo Guedes Candido Marculino

    2010-08-01

    Full Text Available A síndrome de Brown enquadra-se no grupo de estrabismos restritivos e é causada pela limitação de movimento do tendão do oblíquo superior através da tróclea. Caracteriza-se por ortotropia ou hipotropia na primária do olhar, limitação ou ausência de elevação em adução, frequente depressão do olho em adução com anisotropia em V e dução passiva positiva na elevação em adução. Denomina-se síndrome de Brown inflamatória, o distúrbio secundário, que tem como principais causas inflamações locais na órbita e doenças inflamatórias como artrite reumatóide e tenossinovite. Apresentamos o caso de um paciente de 44 anos, do sexo masculino, com queixa de diplopia binocular vertical à dextroversão recorrente. Diagnosticado como síndrome de Brown inflamatória sem etiologia definida, confirmada por ressonância nuclear magnética e com resolução espontânea.Brown syndrome fits the group of restrictive strabismus and is caused by a movement limitation of the superior oblique tendon through the trochlea. It is characterized by parallelism in the primary gaze position, limitation or absence of elevation in adduction, frequent depression of the eye in adduction with anisotropy in V-pattern and positive passive duction in the elevation in adduction. It is called inflammatory Brown syndrome, a secondary disorder, which main causes are local inflammation in the orbit and inflammatory diseases such as rheumatoid arthritis and tenosynovitis. A case of a 44 year-old patient, male, complaining of binocular vertical diplopia due to recurring dextroversion is reported. It was diagnosed as inflammatory Brown syndrome of uncertain etiology, confirmed by magnetic nuclear resonance, and with spontaneous resolution.

  4. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.

    Science.gov (United States)

    Li, Suzanne C; Torok, Kathryn S; Pope, Elena; Dedeoglu, Fatma; Hong, Sandy; Jacobe, Heidi T; Rabinovich, C Egla; Laxer, Ronald M; Higgins, Gloria C; Ferguson, Polly J; Lasky, Andrew; Baszis, Kevin; Becker, Mara; Campillo, Sarah; Cartwright, Victoria; Cidon, Michael; Inman, Christi J; Jerath, Rita; O'Neil, Kathleen M; Vora, Sheetal; Zeft, Andrew; Wallace, Carol A; Ilowite, Norman T; Fuhlbrigge, Robert C

    2012-08-01

    Juvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment has made it difficult to compare approaches and identify optimal therapy. Our objective was to develop standardized treatment plans, clinical assessments, and response criteria for active, moderate to high severity juvenile LS. A core group of pediatric rheumatologists, dermatologists, and a lay advisor was engaged by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) to develop standardized treatment plans and assessment parameters for juvenile LS using consensus methods/nominal group techniques. Recommendations were validated in 2 face-to-face conferences with a larger group of practitioners with expertise in juvenile LS and with the full membership of CARRA, which encompasses the majority of pediatric rheumatologists in the US and Canada. Consensus was achieved on standardized treatment plans that reflect the prevailing treatment practices of CARRA members. Standardized clinical assessment methods and provisional treatment response criteria were also developed. Greater than 90% of pediatric rheumatologists responding to a survey (66% of CARRA membership) affirmed the final recommendations and agreed to utilize these consensus plans to treat patients with juvenile LS. Using consensus methodology, we have developed standardized treatment plans and assessment methods for juvenile LS. The high level of support among pediatric rheumatologists will support future comparative effectiveness studies and enable the development of evidence-based guidelines for the treatment of juvenile LS. Copyright © 2012 by the American College of Rheumatology.

  5. The semantic sphere of juvenile offenders

    Directory of Open Access Journals (Sweden)

    Oshevsky D.S.

    2017-01-01

    Full Text Available The article presents the results of a preliminary empirical study aimed to identify features of the semantic sphere of adolescents who have committed illegal, including aggressive acts. The study included 50 male juveniles aged of 16 - 17 years. The first group consisted of adolescents convicted of aggressive and violent crimes; the second – of property socially dangerous acts (SDA. It is shown that evaluation of such adolescents is generally categorical and polar, the semantic field is subdifferentiable, less hierarchic, and has not enough realistic structure of meanings. Developed structure of motives and meanings is the basis of voluntary regulation of socially significant behavior. Thus, assessing the semantic sphere of juvenile offenders we can highlight its characteristics as risk factors of unlawful behavior, as well as the resource side, that will contribute to addressing issues of prevention and correction of unlawful behavior. Key words: juvenile offenders, semantic field of juvenile offenders, unlawful behavior.

  6. Thermochemical modelling of brown dwarf discs

    NARCIS (Netherlands)

    Greenwood, A. J.; Kamp, I.; Waters, L. B. F. M.; Woitke, P.; Thi, W.-F.; Rab, Ch.; Aresu, G.; Spaans, M.

    The physical properties of brown dwarf discs, in terms of their shapes and sizes, are still largely unexplored by observations. ALMA has by far the best capabilities to observe these discs in sub-mm CO lines and dust continuum, while also spatially resolving some discs. To what extent brown dwarf

  7. Differential heritability of adult and juvenile antisocial traits.

    Science.gov (United States)

    Lyons, M J; True, W R; Eisen, S A; Goldberg, J; Meyer, J M; Faraone, S V; Eaves, L J; Tsuang, M T

    1995-11-01

    Studies of adult antisocial behavior or criminality usually find genetic factors to be more important than the family environment, whereas studies of delinquency find the family environment to be more important. We compared DSM-III-R antisocial personality disorder symptoms before vs after the age of 15 years within a sample of twins, rather than comparing across studies. We administered the Diagnostic Interview Schedule Version III-revised by telephone to 3226 pairs of male twins from the Vietnam Era Twin Registry. Biometrical modeling was applied to each symptom of antisocial personality disorder and summary measures of juvenile and adult symptoms. Five juvenile symptoms were significantly heritable, and five were significantly influenced by the shared environment. Eight adult symptoms were significantly heritable, and one was significantly influenced by the shared environment. The shared environment explained about six times more variance in juvenile anti-social traits than in adult traits. Shared environmental influences on adult antisocial traits overlapped entirely with those on juvenile traits. Additive genetic factors explained about six times more variance in adult vs juvenile traits. The juvenile genetic determinants overlapped completely with genetic influences on adult traits. The unique environment (plus measurement error) explained the largest proportion of variance in both juvenile and adult antisocial traits. Characteristics of the shared or family environment that promote antisocial behavior during childhood and early adolescence also promote later antisocial behavior, but to a much lesser extent. Genetic causal factors are much more prominent for adult than for juvenile antisocial traits.

  8. Production of blast furnace coke from soft brown coal

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, G.; Wundes, H.; Schkommodau, F.; Zinke, H.-G. (VEB Gaskombinat Schwarze Pumpe (German Democratic Republic))

    1988-01-01

    Reviews experimental production and utilization of high quality brown coal coke in the GDR during 1985 and 1986. The technology of briquetting and coking brown coal dust is described; the superior parameters of produced coke quality are listed in comparison to those of regular industrial coke made from brown and black coal. Dust emission from high quality brown coal coke was suppressed by coke surface treatment with dispersion foam. About 4,200 t of this coke were employed in black coal coke substitution tests in a blast furnace. Substitution rate was 11%, blast furnace operation was positive, a substitution factor of 0.7 t black coal coke per 1 t of brown coal coke was calculated. Technology development of high quality brown coal coke production is regarded as complete; blast furnace coke utilization, however, requires further study. 8 refs.

  9. Juveniles' Motivations for Remaining in Prostitution

    Science.gov (United States)

    Hwang, Shu-Ling; Bedford, Olwen

    2004-01-01

    Qualitative data from in-depth interviews were collected in 1990-1991, 1992, and 2000 with 49 prostituted juveniles remanded to two rehabilitation centers in Taiwan. These data are analyzed to explore Taiwanese prostituted juveniles' feelings about themselves and their work, their motivations for remaining in prostitution, and their difficulties…

  10. DERMATOMIOSITIS JUVENIL Y EMBARAZO

    OpenAIRE

    Evans M,Gregorio; Poulsen R,Ronald; Blanco R,Romiely; Luna V,Viviana

    2002-01-01

    La dermatomiositis juvenil es un desorden inflamatorio crónico multisistémico del tejido conectivo. Tiene una incidencia de 2-3/100.000/año. Con la disminución en la mortalidad experimentada en los últimos decenios, la atención está cifrada en la morbilidad a largo plazo y en las alteraciones funcionales. Con un tratamiento agresivo los niños con dermatomiositis juvenil generalmente tienen un futuro promisorio, sin incapacidad o con incapacidad mínima. La mortalidad actualmente se estima cerc...

  11. To cross or not to cross: modeling wildlife road crossings as a binary response variable with contextual predictors

    Science.gov (United States)

    Siers, Shane R.; Reed, Robert N.; Savidge, Julie A.

    2016-01-01

    Roads are significant barriers to landscape-scale movements of individuals or populations of many wildlife taxa. The decision by an animal near a road to either cross or not cross may be influenced by characteristics of the road, environmental conditions, traits of the individual animal, and other aspects of the context within which the decision is made. We considered such factors in a mixed-effects logistic regression model describing the nightly road crossing probabilities of invasive nocturnal Brown Treesnakes (Boiga irregularis) through short-term radiotracking of 691 snakes within close proximity to 50 road segments across the island of Guam. All measures of road magnitude (traffic volume, gap width, surface type, etc.) were significantly negatively correlated with crossing probabilities. Snake body size was the only intrinsic factor associated with crossing rates, with larger snakes crossing roads more frequently. Humidity was the only environmental variable affecting crossing rate. The distance of the snake from the road at the start of nightly movement trials was the most significant predictor of crossings. The presence of snake traps with live mouse lures during a portion of the trials indicated that localized prey cues reduced the probability of a snake crossing the road away from the traps, suggesting that a snake's decision to cross roads is influenced by local foraging opportunities. Per capita road crossing rates of Brown Treesnakes were very low, and comparisons to historical records suggest that crossing rates have declined in the 60+ yr since introduction to Guam. We report a simplified model that will allow managers to predict road crossing rates based on snake, road, and contextual characteristics. Road crossing simulations based on actual snake size distributions demonstrate that populations with size distributions skewed toward larger snakes will result in a higher number of road crossings. Our method of modeling per capita road crossing

  12. AFSC/ABL: Juvenile rockfish DNA species identification

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Many pelagic juvenile rockfish (Sebastes) were collected in juvenile salmonid surveys in the Gulf of Alaska (GOA) from 1998 to 2002. Often species identification of...

  13. The brown coal. Present state and development perspectives

    International Nuclear Information System (INIS)

    Wagenknecht, J.

    1994-01-01

    A present state of Polish power plants fueled by brown coal is presented. Their economic results are compared with the achievements of power stations fueled by black coal. The basic data concerning brown coal reserves, production and consumption are given. The problems of environmental protection are discussed. The different applications of brown coal are mentioned. Its importance for energy balance is stressed. 6 tabs

  14. "Scared Straight" and other juvenile awareness programs for preventing juvenile delinquency.

    Science.gov (United States)

    Petrosino, A; Turpin-Petrosino, C; Buehler, J

    2002-01-01

    'Scared Straight' and other programmes involve organised visits to prison by juvenile delinquents or children at risk for criminal behavior. programmes are designed to deter participants from future offending through first-hand observation of prison life and interaction with adult inmates. These programmes remain in use world-wide despite studies and reviews questioning their effectiveness. To assess the effects of programmes comprising organised visits to prisons by juvenile delinquents (officially adjudicated or convicted by a juvenile court) or pre-delinquents (children in trouble but not officially adjudicated as delinquents), aimed at deterring them from criminal activity. Handsearching by the first author in identifying randomised field trials 1945-1993 relevant to criminology was augmented by structured searches of 16 electronic data bases, including the Campbell SPECTR database of trials and the Cochrane CCTR. Experts in the field were consulted and relevant citations were followed up. Studies that tested the effects of any program involving the organised visits of juvenile delinquents or children at-risk for delinquency to penal institutions were included. Studies that included overlapping samples of juvenile and young adults (e.g. ages 14-20) were included. We only considered studies that randomly or quasi-randomly (i.e. alternation) assigned participants to conditions. Each study had to have a no-treatment control condition with at least one outcome measure of "post-visit" criminal behavior. We report narratively on the nine eligible trials. We conducted one meta-analysis of post-intervention offending rates using official data. Information from other sources (e.g. self-report) was either missing from some studies or critical information was omitted (e.g. standard deviations). We examined the immediate post-treatment effects (i.e. "first-effects") by computing Odds Ratios (OR) for data on proportions of each group re-offending, and assumed both fixed and

  15. Preventing Juvenile Delinquency

    Directory of Open Access Journals (Sweden)

    Carolina dos Reis

    2016-04-01

    Full Text Available This article aims to problematize discourses about protection and care that have surrounded compulsory hospitalization by evidencing its use as a control and punishment mechanism that increases the social vulnerability of young drug users. For such, we analyze lawsuits involving juveniles who were consigned to psychiatric institutions for drug addiction treatment as a protection measure in the state of Rio Grande do Sul, in Brazil. The analysis of the materials has evidenced discourses that have circumscribed young drug users and constructed this population as potentially dangerous subjects as well as a population category at risk. In this sense, we point out how compulsory hospitalization has emerged out of the lawsuits as a tool for prevention of juvenile delinquency.

  16. The brown dwarf kinematics project

    Science.gov (United States)

    Faherty, Jackie K.

    2010-10-01

    Brown dwarfs are a recent addition to the plethora of objects studied in Astronomy. With theoretical masses between 13 and 75 MJupiter , they lack sustained stable Hydrogen burning so they never join the stellar main sequence. They have physical properties similar to both planets and low-mass stars so studies of their population inform on both. The distances and kinematics of brown dwarfs provide key statistical constraints on their ages, moving group membership, absolute brightnesses, evolutionary trends, and multiplicity. Yet, until my thesis, fundamental measurements of parallax and proper motion were made for only a relatively small fraction of the known population. To address this deficiency, I initiated the Brown Dwarf Kinematics (BDKP). Over the past four years I have re-imaged the majority of spectroscopically confirmed field brown dwarfs (or ultracool dwarfs---UCDs) and created the largest proper motion catalog for ultracool dwarfs to date. Using new astrometric information I examined population characteristics such as ages calculated from velocity dispersions and correlations between kinematics and colors. Using proper motions, I identified several new wide co-moving companions and investigated binding energy (and hence formation) limitations as well as the frequency of hierarchical companions. Concurrently over the past four years I have been conducting a parallax survey of 84 UCDs including those showing spectral signatures of youth, metal-poor brown dwarfs, and those within 20 pc of the Sun. Using absolute magnitude relations in J,H, and K, I identified overluminous binary candidates and investigated known flux-reversal binaries. Using current evolutionary models, I compared the MK vs J-K color magnitude diagram to model predictions and found that the low-surface gravity dwarfs are significantly red-ward and underluminous of predictions and a handful of late-type T dwarfs may require thicker clouds to account for their scatter.

  17. The World of Juvenile Justice According to the Numbers

    Science.gov (United States)

    Rozalski, Michael; Deignan, Marilyn; Engel, Suzanne

    2008-01-01

    Intended to be an instructive, yet sobering, introduction to the complex and disturbing nature of the juvenile justice system, this article details the "numbers," including selected percentages, ratios, and dollar amounts, that are relevant to developing a better understanding of the juvenile justice system. General statistics about juvenile and…

  18. HIV testing among non-incarcerated substance-abusing juvenile offenders.

    Science.gov (United States)

    Tolou-Shams, Marina; Conrad, Selby; Louis, Alaina; Shuford, Sarah Hart; Brown, Larry K

    2015-11-01

    Juvenile offenders are a subgroup of adolescents at particular risk for HIV/STI infection. Although HIV prevalence among these youth is low (justice system, which is known to have an extremely high rate of HIV infection. US constitutional mandates provide HIV/STI testing for incarcerated juveniles, but close to 80% of juvenile arrestees are never detained. Moreover, although they engage in similar HIV risk behaviors as those detained, they have limited access to available HIV/STI testing services. Thus, our study examined rates of lifetime HIV testing among a pilot sample of 60 court-involved, substance-using juveniles monitored in the community to explore rates of testing and the reasons related to lifetime testing among a high-risk, yet understudied US juvenile population.

  19. Phylogeography of mitochondrial DNA variation in brown bears and polar bears.

    Science.gov (United States)

    Shields, G F; Adams, D; Garner, G; Labelle, M; Pietsch, J; Ramsay, M; Schwartz, C; Titus, K; Williamson, S

    2000-05-01

    We analyzed 286 nucleotides of the middle portion of the mitochondrial cytochrome b gene of 61 brown bears from three locations in Alaska and 55 polar bears from Arctic Canada and Arctic Siberia to test our earlier observations of paraphyly between polar bears and brown bears as well as to test the extreme uniqueness of mitochondrial DNA types of brown bears on Admiralty, Baranof, and Chichagof (ABC) islands of southeastern Alaska. We also investigated the phylogeography of brown bears of Alaska's Kenai Peninsula in relation to other Alaskan brown bears because the former are being threatened by increased human development. We predicted that: (1) mtDNA paraphyly between brown bears and polar bears would be upheld, (2) the mtDNA uniqueness of brown bears of the ABC islands would be upheld, and (3) brown bears of the Kenai Peninsula would belong to either clade II or clade III of brown bears of our earlier studies of mtDNA. All of our predictions were upheld through the analysis of these additional samples. Copyright 2000 Academic Press.

  20. Phylogeography of mitochondrial DNA variation in brown bears and polar bears

    Science.gov (United States)

    Shields, Gerald F.; Adams, Deborah; Garner, Gerald W.; Labelle, Martine; Pietsch, Jacy; Ramsay, Malcolm; Schwartz, Charles; Titus, Kimberly; Williamson, Scott

    2000-01-01

    We analyzed 286 nucleotides of the middle portion of the mitochondrial cytochrome b gene of 61 brown bears from three locations in Alaska and 55 polar bears from Arctic Canada and Arctic Siberia to test our earlier observations of paraphyly between polar bears and brown bears as well as to test the extreme uniqueness of mitochondrial DNA types of brown bears on Admiralty, Baranof, and Chichagof (ABC) islands of southeastern Alaska. We also investigated the phylogeography of brown bears of Alaska's Kenai Peninsula in relation to other Alaskan brown bears because the former are being threatened by increased human development. We predicted that: (1) mtDNA paraphyly between brown bears and polar bears would be upheld, (2) the mtDNA uniqueness of brown bears of the ABC islands would be upheld, and (3) brown bears of the Kenai Peninsula would belong to either clade II or clade III of brown bears of our earlier studies of mtDNA. All of our predictions were upheld through the analysis of these additional samples.

  1. Browning phenomenon of medieval stained glass windows.

    Science.gov (United States)

    Ferrand, Jessica; Rossano, Stéphanie; Loisel, Claudine; Trcera, Nicolas; van Hullebusch, Eric D; Bousta, Faisl; Pallot-Frossard, Isabelle

    2015-04-07

    In this work, three pieces of historical on-site glass windows dated from the 13th to 16th century and one archeological sample (8th century) showing Mn-rich brown spots at their surface or subsurface have been characterized by optical microscopy and Scanning Electron Microscopy coupled with Energy Dispersive X-ray spectroscopy. The oxidation state of Mn as well as the Mn environment in the alteration phase have been characterized by X-ray absorption spectroscopy at the Mn K-edge. Results show that the oxidation state of Mn and therefore the nature of the alteration phase varies according to the sample considered and is correlated with the extent of the brown alteration. The larger the brown areas the more oxidized the Mn. However, by contrast with literature, the samples presenting the more extended brown areas are not similar to pyrolusite and contain Mn mainly under a (+III) oxidation state.

  2. A Giant Juvenile Nasopharyngeal Angiofibroma

    Science.gov (United States)

    Yüce, Salim; Uysal, İsmail Önder; Doğan, Mansur; Polat, Kerem; Şalk, İsmail; Müderris, Suphi

    2012-01-01

    Juvenile nasopharyngeal angiofibroma (JNA) are locally growing highly vascular tumours. They are treated primarily by surgical excision ranging from open approach to endoscopic approach. We presented a 20-year-old male with a giant nasopharyngeal juvenile angiofibroma obliterating the pterygopalatine fossa bilaterally, invasing the sphenoid bone and extending to the left nasal passage. His complaints were epistaxis and nasal obstruction. After embolization, the patient was treated surgically with endoscopic approach and discharged as cured without any complication. PMID:23714961

  3. Combination of Juvenile Papillomatosis, Juvenile Fibroadenoma and Intraductal Carcinoma of the Breast in a 15-Year-old Girl.

    Science.gov (United States)

    Sedloev, Theophil; Bassarova, Assia; Angelov, Kostadin; Vasileva, Mariela; Asenov, Yavor

    2015-09-01

    The association of juvenile papillomatosis with carcinoma is proven, but very rare, as there exist several reported cases. A 15-year-old girl with no family history of breast cancer presented with two masses in the left breast. The excisional biopsy on both lumps revealed juvenile fibroadenoma and juvenile papillomatosis epithelial proliferation multiple cystic expanded channels. In some of these channels, cytological features of intraductal carcinoma were observed. We performed a full immunohistochemical examination of the juvenile papillomatosis. The patient refused any further surgical or adjuvant treatment. There are no signs of recurrence in the 15 year follow-up. This case is a diagnostic and therapeutic challenge, taking into account the patient's age and the controversial treatment recommendations. Good collaboration between surgeons and pathologists is essential for an accurate diagnostic process and aims to avoid under- or overtreatment. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  4. Challenges and prospects of the juvenile justice administration in ...

    African Journals Online (AJOL)

    Juvenile justice administration in Nigeria is weak and has been given very little priority, despite Nigeria being signatory to the major international instruments relevant to the administration of juvenile justice. This is attributable to the history of the penal system of Nigeria, with laws guiding juvenile justice administration having ...

  5. Brown Recluse Spider

    Science.gov (United States)

    ... to a group of spiders commonly known as violin spiders or fiddlebacks. The characteristic fiddle-shaped pattern ... 4-19.1mm) • Color: Golden brown • A dark violin/fiddle shape (see top photo) is located on ...

  6. The male handicap: male-biased mortality explains skewed sex ratios in brown trout embryos.

    Science.gov (United States)

    Morán, P; Labbé, L; Garcia de Leaniz, C

    2016-12-01

    Juvenile sex ratios are often assumed to be equal for many species with genetic sex determination, but this has rarely been tested in fish embryos due to their small size and absence of sex-specific markers. We artificially crossed three populations of brown trout and used a recently developed genetic marker for sexing the offspring of both pure and hybrid crosses. Sex ratios (SR = proportion of males) varied widely one month after hatching ranging from 0.15 to 0.90 (mean = 0.39 ± 0.03). Families with high survival tended to produce balanced or male-biased sex ratios, but SR was significantly female-biased when survival was low, suggesting that males sustain higher mortality during development. No difference in SR was found between pure and hybrid families, but the existence of sire × dam interactions suggests that genetic incompatibility may play a role in determining sex ratios. Our findings have implications for animal breeding and conservation because skewed sex ratios will tend to reduce effective population size and bias selection estimates. © 2016 The Authors.

  7. Browns Ferry

    International Nuclear Information System (INIS)

    Wood, J.

    1996-01-01

    In 1986, the US Nuclear Regulatory Commission (NRC) established a ''watch list'' of power reactors requiring special attention which included the three BWR units at Brown's Ferry owned by the Tennessee Valley Authority (TVA). The reactors has been closed down voluntarily by the TVA in 1985 in order to deal with a backlog of maintenance and regulatory issues. Intended as short-term, the shutdown was indefinitely extended when the nature and extent of the design changes, accompanying documentation and retrofitting required to satisfy the NRC became apparent. The recovery programme for Unit 2 was completed by 1991 and the reactor returned to service under a dedicated operating staff. Meanwhile, a separate, dedicated, recovery team was set up to manage Unit 3 which was returned to service in December 1995. Browns Ferry 2 was removed from the NRC watch list in June 1992 and Units 1 and 3 in June 1996. Units 2 and 3 have both operated successfully since restart but Unit 1 is currently mothballed and TVA has no plans to bring it back into service. (UK)

  8. An Evolutionary Approach to the Biological Management of Invasive Brown Treesnakes (Boiga irregularis) on Guam

    Science.gov (United States)

    2012-03-14

    only two snake species on the Guam, the other of which is a burrowing blind snake Ramphotyphlops braminus (possibly introduced as well), and none of...descriptions of three new species. Systematic Parasitology 1:127-140. Roberts, L. S. and J. J. Janovy. 2005. Gerald D. Schmidt and Larry S. Roberts

  9. The relative absorption of fatty acids in brown trout (Salmo trutta fed a commercial extruded pellet coated with different lipid sources

    Directory of Open Access Journals (Sweden)

    Franco Valfré

    2010-01-01

    Full Text Available The objective of the present study was to investigate the fatty acid absorption capabilities of brown trout (Salmo trut- ta fed commercial extruded diets. Five commercial extruded pellets, different only in the lipid sources used for fat coat- ing, were tested on juvenile brown trout for 45 days. The trout were reared in fresh water at 14.6 ± 0.4° C and 7.7 ± 0.3 mg/l, temperature and dissolved oxygen, respectively. The tested lipid sources were fish oil, canola oil, oleine oil, swine fat and poultry fat. After the adaptation period faeces were collected by gently stripping from anaesthetized fish. Fatty acid analysis was performed on experimental diets and on collected faeces to evaluate the relative absorption capabilities of the trout digestive system with respect to each detected fatty acid. The use of the relative absorption efficiency (rAE was opted to evaluate the intrinsic capability of each fatty acid to be absorbed. Brown trout showed a specific preferential order of absorption of the fatty acids, preferring shorter over longer chain fatty acids and prefer- ring the more unsaturated to the more saturated fatty acids. The fatty acid that showed the best relative absorbability was the C18:4n-3 (rAE = 5.14 ± 0.72, which has a fairly short carbon chain, but at the same time a high unsatura- tion level, followed by the C18:3n-3 (rAE = 3.38 ± 0.30. The fatty acid that showed the worst relative absorbability (rAE = 0.21 ± 0.02 was C24:1n-9.

  10. A new mass mortality of juvenile Protoceratops and size-segregated aggregation behaviour in juvenile non-avian dinosaurs.

    Directory of Open Access Journals (Sweden)

    David W E Hone

    Full Text Available BACKGROUND: Monodominant bonebeds are a relatively common occurrence for non-avian dinosaurs, and have been used to infer associative, and potentially genuinely social, behavior. Previously known assemblages are characterized as either mixed size-classes (juvenile and adult-sized specimens together or single size-classes of individuals (only juveniles or only adult-sized individuals within the assemblage. In the latter case, it is generally unknown if these kinds of size-segregated aggregations characterize only a particular size stage or represent aggregations that happened at all size stages. Ceratopsians ("horned dinosaurs" are known from both types of assemblages. METHODS/PRINCIPAL FINDINGS: Here we describe a new specimen of the ceratopsian dinosaur Protoceratops andrewsi, Granger and Gregory 1923 from Mongolia representing an aggregation of four mid-sized juvenile animals. In conjunction with existing specimens of groups of P. andrewsi that includes size-clustered aggregations of young juveniles and adult-sized specimens, this new material provides evidence for some degree of size-clustered aggregation behaviour in Protoceratops throughout ontogeny. This continuity of size-segregated (and presumably age-clustered aggregation is previously undocumented in non-avian dinosaurs. CONCLUSIONS: The juvenile group fills a key gap in the available information on aggregations in younger ceratopsians. Although we support the general hypothesis that many non-avian dinosaurs were gregarious and even social animals, we caution that evidence for sociality has been overstated and advocate a more conservative interpretation of some data of 'sociality' in dinosaurs.

  11. A new mass mortality of juvenile Protoceratops and size-segregated aggregation behaviour in juvenile non-avian dinosaurs.

    Science.gov (United States)

    Hone, David W E; Farke, Andrew A; Watabe, Mahito; Shigeru, Suzuki; Tsogtbaatar, Khishigjav

    2014-01-01

    Monodominant bonebeds are a relatively common occurrence for non-avian dinosaurs, and have been used to infer associative, and potentially genuinely social, behavior. Previously known assemblages are characterized as either mixed size-classes (juvenile and adult-sized specimens together) or single size-classes of individuals (only juveniles or only adult-sized individuals within the assemblage). In the latter case, it is generally unknown if these kinds of size-segregated aggregations characterize only a particular size stage or represent aggregations that happened at all size stages. Ceratopsians ("horned dinosaurs") are known from both types of assemblages. Here we describe a new specimen of the ceratopsian dinosaur Protoceratops andrewsi, Granger and Gregory 1923 from Mongolia representing an aggregation of four mid-sized juvenile animals. In conjunction with existing specimens of groups of P. andrewsi that includes size-clustered aggregations of young juveniles and adult-sized specimens, this new material provides evidence for some degree of size-clustered aggregation behaviour in Protoceratops throughout ontogeny. This continuity of size-segregated (and presumably age-clustered) aggregation is previously undocumented in non-avian dinosaurs. The juvenile group fills a key gap in the available information on aggregations in younger ceratopsians. Although we support the general hypothesis that many non-avian dinosaurs were gregarious and even social animals, we caution that evidence for sociality has been overstated and advocate a more conservative interpretation of some data of 'sociality' in dinosaurs.

  12. Phytochemical Profile of Brown Rice and Its Nutrigenomic Implications

    Directory of Open Access Journals (Sweden)

    Keneswary Ravichanthiran

    2018-05-01

    Full Text Available Whole grain foods have been promoted to be included as one of the important components of a healthy diet because of the relationship between the regular consumption of whole-grain foods and reduced risk of chronic diseases. Rice is a staple food, which has been widely consumed for centuries by many Asian countries. Studies have suggested that brown rice is associated with a wide spectrum of nutrigenomic implications such as anti-diabetic, anti-cholesterol, cardioprotective and antioxidant. This is because of the presence of various phytochemicals that are mainly located in bran layers of brown rice. Therefore, this paper is a review of publications that focuses on the bioactive compounds and nutrigenomic implications of brown rice. Although current evidence supports the fact that the consumption of brown rice is beneficial for health, these studies are heterogeneous in terms of their brown rice samples used and population groups, which cause the evaluation to be difficult. Future clinical studies should focus on the screening of individual bioactive compounds in brown rice with reference to their nutrigenomic implications.

  13. Sports Participation and Juvenile Delinquency: A Meta-Analytic Review.

    Science.gov (United States)

    Spruit, Anouk; van Vugt, Eveline; van der Put, Claudia; van der Stouwe, Trudy; Stams, Geert-Jan

    2016-04-01

    Participation in sports activities is very popular among adolescents, and is frequently encouraged among youth. Many psychosocial health benefits in youth are attributed to sports participation, but to what extent this positive influence holds for juvenile delinquency is still not clear on both the theoretical and empirical level. There is much controversy on whether sports participation should be perceived as a protective or a risk factor for the development of juvenile delinquency. A multilevel meta-analysis of 51 published and unpublished studies, with 48 independent samples containing 431 effect sizes and N = 132,366 adolescents, was conducted to examine the relationship between sports participation and juvenile delinquency and possible moderating factors of this association. The results showed that there is no overall significant association between sports participation and juvenile delinquency, indicating that adolescent athletes are neither more nor less delinquent than non-athletes. Some study, sample and sports characteristics significantly moderated the relationship between sports participation and juvenile delinquency. However, this moderating influence was modest. Implications for theory and practice concerning the use of sports to prevent juvenile delinquency are discussed.

  14. Moral development of solo juvenile sex offenders

    NARCIS (Netherlands)

    van Vugt, E.; Stams, G.J.; Dekovic, M.; Brugman, D.; Rutten, E.; Hendriks, J.

    2008-01-01

    This study compared the moral development of solo juvenile male sex offenders (n = 20) and juvenile male non-offenders (n = 76), aged 13-19 years, from lower socioeconomic and educational backgrounds. The Moral Orientation Measure (MOM) was used to assess punishment- and victim-based moral

  15. Search for brown dwarfs in the IRAS data bases

    International Nuclear Information System (INIS)

    Low, F.J.

    1986-01-01

    A report is given on the initial searches for brown dwarf stars in the IRAS data bases. The paper was presented to the workshop on 'Astrophysics of brown dwarfs', Virginia, USA, 1985. To date no brown dwarfs have been discovered in the solar neighbourhood. Opportunities for future searches with greater sensitivity and different wavelengths are outlined. (U.K.)

  16. Exposure of Brown Recluse and Brown Widow Spiders (Araneae: Sicariidae, Theridiidae) to a Commercial Sulfuryl Fluoride Fumigation.

    Science.gov (United States)

    Vetter, Richard S; Hoddle, Mark S; Choe, Dong-Hwan; Thoms, Ellen

    2014-10-01

    The body of pesticide research on spiders is sparse with most studies using topical or residual applications to assess efficacy. Data on the effects of fumigation on spider survivorship are scarce in the scientific literature. In this study, we exposed adult male and female brown recluse spiders, Loxosceles reclusa Gertsch & Mulaik, and female brown widow spiders, Latrodectus geometricus C. L. Koch, to a commercial fumigation event using sulfuryl fluoride directed at termite control. General consensus from the pest control industry is that fumigation is not always effective for control of spiders for a variety of reasons, including insufficient fumigant dosage, particularly, for contents of egg sacs that require a higher fumigant dosage for control. We demonstrated that a sulfuryl fluoride fumigation with an accumulated dosage of 162 oz-h per 1,000 ft(3) at 21°C over 25 h (≈1.7 × the drywood termite dosage) directed at termites was sufficient to kill adult brown recluse and brown widow spiders. The effectiveness of commercial fumigation practices to control spiders, and particularly their egg sacs, warrants further study. © 2014 Entomological Society of America.

  17. Mink predation on brown trout in a Black Hills stream

    Science.gov (United States)

    Davis, Jacob L.; Wilhite, Jerry W.; Chipps, Steven R.

    2016-01-01

    In the early 2000’s, declines in the brown trout (Salmo trutta) fishery in Rapid Creek, South Dakota, caused concern for anglers and fisheries managers. We conducted a radio telemetry study in 2010 and 2011 to identify predation mortality associated with mink, using hatchery-reared (2010) or wild (2011) brown trout. Estimated predation rates by mink (Mustela vison) on radio-tagged brown trout were 30% for hatchery fish and 32% for wild fish. Size frequency analysis revealed that the size distribution of brown trout lost to predation was similar to that of other, radio-tagged brown trout. In both years, a higher proportion of predation mortality (83–92%) occurred during spring, consistent with seasonal fish consumption by mink. Predation by mink appeared to be a significant source of brown trout mortality in our study.

  18. Properties of sorbents from brown coal

    Energy Technology Data Exchange (ETDEWEB)

    Straka, P.; Buchtele, J. [Academy of Sciences of the Czech Republic, Prague (Czech Republic)

    2000-07-01

    The surface and sorptional properties of carbonaceous materials prepared from brown coal and their relation to minerals content and coal bulk density as technologically important parameters of starting coal were described. Chars were prepared from brown coal of North Bohemian Brown Coal District and activated with CO{sub 2} in a large-scale laboratory unit. Their surface and sorptive properties were investigated. It was found that mineral matter/ash content favourably affects the mesoporosity development in chars/activated chars as the sorption capacity increased with increasing ash content in chars. No influence of ash content on the macroporosity was observed. With the activated chars, both the inner surface and sorption capacity showed the maximum in the burn-off range of 41-64%. Optimization of the process is discussed.

  19. EVIDENCE FOR ACCRETION IN A NEARBY, YOUNG BROWN DWARF

    International Nuclear Information System (INIS)

    Reiners, Ansgar

    2009-01-01

    We report on the discovery of the young, nearby, brown dwarf 2MASS J0041353-562112. The object has a spectral type of M7.5; it shows Li absorption and signatures of accretion, which implies that it still has a disk and suggests an age below 10 Myr. The space motion vector and position on the sky indicate that the brown dwarf is probably a member of the ∼20 Myr old Tuc-Hor association, or that it may be an ejected member of the ∼12 Myr old β Pic association; both would imply that 2MASS J0041353-562112 may in fact be older than 10 Myr. No accreting star or brown dwarf was previously known in these associations. Assuming an age of 10 Myr, the brown dwarf has a mass of about 30 M Jup and is located at 35 pc distance. The newly discovered object is the closest accreting brown dwarf known. Its membership to an association older than 10 Myr implies that either disks in brown dwarfs can survive as long as in more massive stars, perhaps even longer, or that star formation in Tuc-Hor or β Pic occurred more recently than previously thought. The history and evolution of this object can provide new fundamental insight into the formation process of stars, brown dwarfs, and planets.

  20. Juvenil idiopatisk arthritis

    DEFF Research Database (Denmark)

    Herlin, Troels

    2002-01-01

    The new classification of juvenile idiopathic arthritis (JIA) is described in this review. Clinical characteristics divide JIA in to subtypes: systemic, oligoarticular (persistent and extended type), RF-positive and--negative polyarticular, enthesitis-related arthritis and psoriatic arthritis...

  1. Fermented Brown Rice Flour as Functional Food Ingredient

    OpenAIRE

    Ilowefah, Muna; Chinma, Chiemela; Bakar, Jamilah; Ghazali, Hasanah; Muhammad, Kharidah; Makeri, Mohammad

    2014-01-01

    As fermentation could reduce the negative effects of bran on final cereal products, the utilization of whole-cereal flour is recommended, such as brown rice flour as a functional food ingredient. Therefore, this study aimed to investigate the effect of fermented brown rice flour on white rice flour, white rice batter and its steamed bread qualities. Brown rice batter was fermented using commercial baker?s yeast (Eagle brand) according to the optimum conditions for moderate acidity (pH 5.5) to...

  2. SURPRISINGLY WEAK MAGNETISM ON YOUNG ACCRETING BROWN DWARFS

    International Nuclear Information System (INIS)

    Reiners, A.; Basri, G.; Christensen, U. R.

    2009-01-01

    We have measured the surface magnetic flux on four accreting young brown dwarfs and one nonaccreting young very low mass (VLM) star utilizing high-resolution spectra of absorption lines of the FeH molecule. A magnetic field of 1-2 kG had been proposed for one of the brown dwarfs, Two Micron All Sky Survey (2MASS) J1207334-393254, because of its similarities to higher mass T Tauri stars as manifested in accretion and the presence of a jet. We do not find clear evidence for a kilogauss field in any of our young brown dwarfs but do find a 2 kG field on the young VLM star. Our 3σ upper limit for the magnetic flux in 2MASS J1207334-393254 just reaches 1 kG. We estimate the magnetic field required for accretion in young brown dwarfs given the observed rotations, and find that fields of only a few hundred gauss are sufficient for magnetospheric accretion. This predicted value is less than our observed upper limit. We conclude that magnetic fields in young brown dwarfs are a factor of 5 or more lower than in young stars of about one solar mass, and in older stars with spectral types similar to our young brown dwarfs. It is interesting that, during the first few million years, the fields scale down with mass in line with what is needed for magnetospheric accretion, yet no such scaling is observed at later ages within the same effective temperature range. This scaling is opposite to the trend in rotation, with shorter rotation periods for very young accreting brown dwarfs compared with accreting solar-mass objects (and very low Rossby numbers in all cases). We speculate that in young objects a deeper intrinsic connection may exist between magnetospheric accretion and magnetic field strength, or that magnetic field generation in brown dwarfs may be less efficient than in stars. Neither of these currently has an easy physical explanation.

  3. Orofacial pain, jaw function, and temporomandibular disorders in adult women with a history of juvenile chronic arthritis or persistent juvenile chronic arthritis

    DEFF Research Database (Denmark)

    Bakke, M.; Zak, M.; Jensen, B.L.

    2001-01-01

    Orofacial pain, jaw function, temporomandibular disorders, adult women persistent juvenil chronic arthritis......Orofacial pain, jaw function, temporomandibular disorders, adult women persistent juvenil chronic arthritis...

  4. Browns Ferry fire

    International Nuclear Information System (INIS)

    Harkleroad, J.R.

    1983-01-01

    A synopsis of the March 22, 1975 fire at Browns Ferry Nuclear Plant is discussed. Emphasis is placed on events prior to and during the fire. How the fire started, fire fighting activities, fire and smoke development, and restoration activities are discussed

  5. Unusual Slowly Rotating Brown Dwarfs Discovered through Precision Spitzer Photometry

    Science.gov (United States)

    Heinze, Aren; Metchev, S.

    2014-01-01

    Many brown dwarfs exhibit low-amplitude rotationally modulated variability due to photospheric inhomogeneities caused by condensate clouds in their atmospheres. The Spitzer Space Telescope 'Weather on Other Worlds' (WoW) project has monitored 44 brown dwarfs at unprecedented photometric precision from space. We present one of several important new results from WoW: the discovery of brown dwarfs with unexpectedly slow rotation periods. While most brown dwarfs have periods of 2-12 hours, we have identified two with well-constrained periods of 13±1 and >20 hours, respectively, and 2 others that show more tentative evidence of longer than 20-hour periods. By serving as almost non-rotating standards, these objects will allow more accurate calibration of spectroscopic measurements of brown dwarfs' projected rotational velocities. The existence of such slowly-rotating objects also constrains models of brown dwarf formation and angular momentum evolution.

  6. Juvenile Obesity, Physical Activity, and Lifestyle Changes.

    Science.gov (United States)

    Bar-Or, Oded

    2000-01-01

    Because many obese children become obese adults, the recent rapid increase in juvenile obesity poses a major public health challenge. Enhanced physical activity is a cornerstone in a multidisciplinary approach to preventing and treating juvenile obesity. Giving exercise recommendations focused for obese youth is critical. Cutting down on sedentary…

  7. Preliminary evidence of altered biomechanics in adolescents with juvenile fibromyalgia.

    Science.gov (United States)

    Sil, Soumitri; Thomas, Staci; DiCesare, Christopher; Strotman, Daniel; Ting, Tracy V; Myer, Gregory; Kashikar-Zuck, Susmita

    2015-01-01

    Juvenile fibromyalgia (FM) is characterized by chronic musculoskeletal pain and marked reduction in physical activity. Despite recommendations for exercise to manage juvenile FM pain, exercise adherence is poor. Because of pain and activity avoidance, adolescents with juvenile FM are at risk for altered joint mechanics that may make them susceptible to increased pain and reduced tolerance for exercise. The primary aim of this study was to assess functional deficits in patients with juvenile FM compared to healthy controls using objective biomechanical assessment. Female adolescent patients with juvenile FM (n = 17) and healthy controls (n = 14) completed biomechanical assessments, including gait analysis and tests of lower extremity strength (isokinetic knee extension/flexion and hip abduction) and functional performance (drop vertical jump test) along with self-reported measures of disability (Functional Disability Inventory), pain intensity, depressive symptoms (Children's Depression Inventory), and fear of movement (Tampa Scale of Kinesiophobia). Patients with juvenile FM demonstrated mild deficiencies in walking gait and functional performance (P < 0.05 for both) and significantly lower left knee extension and flexion strength (18-22% deficit) and bilateral hip abduction strength (34-38%) compared with healthy controls (P < 0.008 for all). Patients with juvenile FM reported significantly higher functional disability, pain intensity, depressive symptoms, and fear of movement relative to controls (P < 0.01 for all). This study showed that adolescents with juvenile FM exhibited objective alterations in biomechanics and self-reported fear of movement that may have reinforced their activity avoidance. Interventions for juvenile FM should include a focus on correcting functional deficits and instilling greater confidence in adolescents with juvenile FM to engage in exercise to improve functional outcomes. Copyright © 2015 by the American College of Rheumatology.

  8. Examination of the influence of juvenile Atlantic salmon on the feeding mode of juvenile steelhead in Lake Ontario tributaries

    Science.gov (United States)

    Johnson, James H.; Waldt, Emily M.

    2014-01-01

    We examined diets of 1204 allopatric and sympatric juvenile Atlantic salmon (Salmo salar) and steelhead (Oncorhynchus mykiss) in three tributaries of Lake Ontario. The diet composition of both species consisted primarily of ephemeropterans, trichopterans, and chironomids, although juvenile steelhead consumed more terrestrial invertebrates, especially at the sympatric sites. Subyearlings of both species consumed small prey (i.e. chironomids) whereas large prey (i.e. perlids) made up a higher percentage of the diet of yearlings. The diet of juvenile steelhead at the allopatric sites was more closely associated with the composition of the benthos than with the drift, but was about equally associated with the benthos and drift at the sympatric sites. The diet of both subyearling and yearling Atlantic salmon was more closely associated with the benthos than the drift at the sympatric sites. The evidence suggests that juvenile steelhead may subtly alter their feeding behavior in sympatry with Atlantic salmon. This behavioral adaptation may reduce competitive interactions between these species.

  9. Platform construction of molecular breeding for utilization of brown macroalgae.

    Science.gov (United States)

    Takagi, Toshiyuki; Kuroda, Kouichi; Ueda, Mitsuyoshi

    2018-01-01

    Brown macroalgae are characterized by a large size and high productivity without requiring arable land, fresh water, and fertilizer. Furthermore, since brown macroalgae contain little or no lignin, simple biorefinery processing can efficiently produce sugars from this material. Therefore, brown macroalgae have attracted attention as an alternative feedstock for bioethanol production. However, the utilization of biotechnologies previously developed for terrestrial biomass processing results in difficulties in the bioconversion of brown macroalgae. Recently, several studies have developed biotechnologies for using major carbohydrates of brown macroalgae, such as laminarin, mannitol, and alginate. This review focuses on these fermentation biotechnologies using natural or engineered microorganisms. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  10. Intelligence Score Profiles of Female Juvenile Offenders

    Science.gov (United States)

    Werner, Shelby Spare; Hart, Kathleen J.; Ficke, Susan L.

    2016-01-01

    Previous studies have found that male juvenile offenders typically obtain low scores on measures of intelligence, often with a pattern of higher scores on measures of nonverbal relative to verbal tasks. The research on the intelligence performance of female juvenile offenders is limited. This study explored the Wechsler Intelligence Scale for…

  11. Penalty responsibility of juveniles in the Republic of Srpska

    Directory of Open Access Journals (Sweden)

    Grbić-Pavlović Nikolina

    2011-01-01

    Full Text Available The youngest members of organized society, more intensive than ever enter the circle of those whose behavior is deviant. Juvenile delinquency is a social problem, which recently experienced an expansion in all modern countries, including Bosnia and Herzegovina and the Republic of Srpska. Considering the fact that juvenile delinquency includes lighter criminal conducts, such as, for example misdemeanors, in this paper a position of juveniles when they are a perpetrators of misdemeanors will be analyzed. Also, the paper will statistically show the number of misdemeanors in the field of public peace and order that juveniles conducted in the Republic of Srpska in the period 2004-2009.

  12. Delincuencia y responsabilidad penal juvenil en Colombia

    Directory of Open Access Journals (Sweden)

    Cristina Montalvo Velásquez

    2011-01-01

    Full Text Available ResumenEl término «delincuencia juvenil» fue acuñado en Inglaterra en el año 1815, “Se entiende por delincuencia juvenil el conjunto de delitos, contravenciones o comportamientos socialmente reprochables, que cometen las personas consideradas como jóvenes por la ley”1 . Cada Estado está sujeto a su propio sistema jurídico, para algunos es delincuente juvenil el adolescente que comete acciones sancionadas por la ley sin importar su gravedad, otros Estados sólo consideran como delincuente juvenil al joven que comete un acto delictivo grave.El fenómeno de la delincuencia juvenil es algo que se inscribe en los espacios de una sociedad en la cual su estructura material, y su formación social consecuente, se halla en una profunda crisis. Que jóvenes conformen bandas de delincuencia organizada nos está indicando que son el resultado de la misma criminalidad general que se ha apoderado de la sociedad en la perspectiva de lograr sobrevivir materialmente. El capitalismo no es sólo acumulación de riqueza sino concentración de la misma en muy pocas manos; y todo el sistema institucional y legal tiende a favorecer ese fenómeno porque éste constituye la supra estructura del modo de producción capitalista. Así como los adultos se organizan para delinquir, lo hacen los niños y los jóvenes a partir de una edad en la cual pueden percibir que la sociedad no es sana y no tienen porvenir humano en ella. Abandonados y sujetos a la violencia que engendra el sistema, ellos simplemente responden en una manifestación de reflejos condicionados que sostienen la sobrevivencia en forma instintiva; “los niños no saben de normas legales sino de formas de sobrevivir a semejante situación; el instinto de sobrevivencia no tiene edades ni la normatividad puede incidir en él”.Palabras ClavesDelincuencia juvenil, Jóvenes, Criminalidad, Familia, Factores, Acto delictivo, Responsabilidad Penal.AbstractThe term “juvenile delinquency” was coined in

  13. Evolution of Juvenile Ankylosing Spondylitis

    Directory of Open Access Journals (Sweden)

    Ye.V. Prohorov

    2013-02-01

    Full Text Available Evolution of juvenile ankylosing spondylitis tend to follow a more frequent involvement in the pathological process of elbow and ankle joints, development of enthesiopathies, changes of intraarticular meniscal horns, forming of Baker’s cysts, cartilage flaps and systemic osteoporosis, and total value of all these signs 13 times exceeds thereof in patients with with the debut of disease in adulthood, but for juvenile ankylosing spondylitis vertebral lesion is less common. Age dimorphism of the use of certain groups of drugs and physiotherapy facilities is observed.

  14. Yolo Bypass Juvenile Salmon Utilization Study 2016—Summary of acoustically tagged juvenile salmon and study fish release, Sacramento River, California

    Science.gov (United States)

    Liedtke, Theresa L.; Hurst, William R.

    2017-09-12

    The Yolo Bypass is a flood control bypass in Sacramento Valley, California. Flood plain habitats may be used for juvenile salmon rearing, however, the potential value of such habitats can be difficult to evaluate because of the intermittent nature of inundation events. The Yolo Bypass Juvenile Salmon Utilization Study (YBUS) used acoustic telemetry to evaluate the movements and survival of juvenile salmon adjacent to and within the Yolo Bypass during the winter of 2016. This report presents numbers, size data, and release data (times, dates, and locations) for the 1,197 acoustically tagged juvenile salmon released for the YBUS from February 21 to March 18, 2016. Detailed descriptions of the surgical implantation of transmitters are also presented. These data are presented to support the collaborative, interagency analysis and reporting of the study findings.

  15. Prevalence of traumatic brain injury in juvenile offenders: a meta-analysis.

    Science.gov (United States)

    Farrer, Thomas J; Frost, R Brock; Hedges, Dawson W

    2013-01-01

    Studies of traumatic brain injury (TBI) among adult populations demonstrate that such injuries can lead to aggressive behaviors. Related findings suggest that incarcerated individuals have high rates of brain injuries. Such studies suggest that traumatic brain injury may be related to the etiology and recidivism of criminal behavior. Relatively few studies have examined the prevalence of TBI using a delinquent juvenile sample. In order to assess the relationship between TBI and juvenile offender status, the current study used meta-analytic techniques to examine the odds of having a TBI among juvenile offenders. Across 9 studies, we found that approximately 30% of juvenile offenders have sustained a previous brain injury. Across 5 studies that used a control group, a calculated summary odds ratio of 3.37 suggests that juvenile offenders are significantly more likely to have a TBI compared to controls. Results suggest that the rate of TBIs within the juvenile offender population is significant and that there may be a relationship between TBIs and juvenile criminal behavior.

  16. How Glassy States Affect Brown Carbon Production?

    Science.gov (United States)

    Liu, P.; Li, Y.; Wang, Y.; Bateman, A. P.; Zhang, Y.; Gong, Z.; Gilles, M. K.; Martin, S. T.

    2015-12-01

    Secondary organic material (SOM) can become light-absorbing (i.e. brown carbon) via multiphase reactions with nitrogen-containing species such as ammonia and amines. The physical states of SOM, however, potentially slow the diffusion of reactant molecules in organic matrix under conditions that semisolids or solids prevail, thus inhibiting the browning reaction pathways. In this study, the physical states and the in-particle diffusivity were investigated by measuring the evaporation kinetics of both water and organics from aromatic-derived SOMs using a quartz-crystal-microbalance (QCM). The results indicate that the SOMs derived from aromatic precursors toluene and m-xylene became solid (glassy) and the in particle diffusion was significantly impeded for sufficiently low relative humidity ( toluene-derived SOM after ammonia exposure at varied RHs. The results suggest that the production of light-absorbing nitrogen-containing compounds from multiphase reactions with ammonia was kinetically limited in the glassy organic matrix, which otherwise produce brown carbon. The results of this study have significant implications for production and optical properties of brown carbon in urban atmospheres that ultimately influence the climate and tropospheric photochemistry.

  17. Movement and mortality of stocked brown trout in a stream

    DEFF Research Database (Denmark)

    Aarestrup, Kim; Jepsen, Niels; Koed, Anders

    2005-01-01

    The movement and mortality of stocked brown trout Salmo trutta were investigated using radio telemetry. Four brown trout left the study area whereas the remaining fish were stationary. After 5 weeks, 13 out of 50 tagged brown trout were still alive in the stream. Surviving fish had a significantly...

  18. Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption

    DEFF Research Database (Denmark)

    Winther, Sally; Isidor, Marie Sophie; Basse, Astrid Linde

    2018-01-01

    During thermogenic activation, brown adipocytes take up large amounts of glucose. In addition, cold stimulation leads to an upregulation of glycolytic enzymes. Here we have investigated the importance of glycolysis for brown adipocyte glucose consumption and thermogenesis. Using siRNA-mediated kn......During thermogenic activation, brown adipocytes take up large amounts of glucose. In addition, cold stimulation leads to an upregulation of glycolytic enzymes. Here we have investigated the importance of glycolysis for brown adipocyte glucose consumption and thermogenesis. Using si...... of glycolysis, i.e., hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption. HK2 knockdown had a more severe effect, which, in contrast to PKM knockdown, could not be rescued by supplementation with pyruvate. Hence, brown adipocytes rely...... on glucose consumption and glycolytic flux to achieve maximum thermogenic output, with glycolysis likely supporting thermogenesis not only by pyruvate formation but also by supplying intermediates for efferent metabolic pathways....

  19. Miastenia gravis juvenil Juvenile myasthenia gravis

    OpenAIRE

    Oscar Papazian; Israel Alfonso; Nayle Araguez

    2009-01-01

    La miastenia gravis juvenil (MGJ) es un trastorno crónico auto inmune en el cual existen anticuerpos séricos que al unirse a los receptores de acetilcolin nicotínicos de la membrana muscular de la placa motora alteran la transmisión neuromuscular. El resultado es fatiga muscular precoz con progresión a la parálisis durante estados de contracción muscular iterativos (movimientos) o sostenidos (posturas) y más raramente parálisis permanente durante el reposo. Los músculos inervados por los nerv...

  20. Temporal stability and rates of post-depositional change in geochemical signatures of brown trout Salmo trutta scales.

    Science.gov (United States)

    Ryan, D; Shephard, S; Kelly, F L

    2016-09-01

    This study investigates temporal stability in the scale microchemistry of brown trout Salmo trutta in feeder streams of a large heterogeneous lake catchment and rates of change after migration into the lake. Laser-ablation inductively coupled plasma mass spectrometry was used to quantify the elemental concentrations of Na, Mg, Mn, Cu, Zn, Ba and Sr in archived (1997-2002) scales of juvenile S. trutta collected from six major feeder streams of Lough Mask, County Mayo, Ireland. Water-element Ca ratios within these streams were determined for the fish sampling period and for a later period (2013-2015). Salmo trutta scale Sr and Ba concentrations were significantly (P < 0·05) correlated with stream water sample Sr:Ca and Ba:Ca ratios respectively from both periods, indicating multi-annual stability in scale and water-elemental signatures. Discriminant analysis of scale chemistries correctly classified 91% of sampled juvenile S. trutta to their stream of origin using a cross-validated classification model. This model was used to test whether assumed post-depositional change in scale element concentrations reduced correct natal stream classification of S. trutta in successive years after migration into Lough Mask. Fish residing in the lake for 1-3 years could be reliably classified to their most likely natal stream, but the probability of correct classification diminished strongly with longer lake residence. Use of scale chemistry to identify natal streams of lake S. trutta should focus on recent migrants, but may not require contemporary water chemistry data. © 2016 The Fisheries Society of the British Isles.

  1. Browns Ferry charcoal adsorber incident

    International Nuclear Information System (INIS)

    Mays, G.T.

    1979-01-01

    The article reviews the temperature excursion in the charcoal adsorber beds of the Browns Ferry Unit 3 off-gas system that occurred on July 17, 1977. Significant temperature increases were experienced in the charcoal adsorber beds when charcoal fines were ignited by the ignition of a combustible mixture of hydrogen and oxygen in the off-gas system. The Browns Ferry off-gas system is described, and events leading up to and surrounding the incident are discussed. The follow-up investigation by Tennessee Valley Authority and General Electric Company personnel and their recommendations for system and operational modifications are summarized

  2. Juvenile xanthogranuloma of the corneoscleral limbus.

    Science.gov (United States)

    Yanoff, M; Perry, H D

    1995-07-01

    Juvenile xanthogranuloma is a rare and usually benign skin disease of unknown cause that occurs in infants and young children. We studied a case of juvenile xanthogranuloma of the corneoscleral limbus in a 17-year-old black boy, who presented with a 5-month history of a lump in the right eye. The lesion extended from the superior limbus, fanning out as it proceeded posteriorly for 6 mm with a width of 9 mm and a height of 2 to 3 mm. This yellow-orange mass was vascular and firmly fixed to the underlying tissue. The lesion was diagnosed as a dermoid and observed for 7 months without documented growth before an uneventful excisional biopsy was performed. The pathologic diagnosis showed the characteristic picture of juvenile xanthogranuloma with numerous Touton giant cells. Lipid stains provided further confirmation.

  3. Unexpected strong polygyny in the brown-throated three-toed sloth.

    Directory of Open Access Journals (Sweden)

    Jonathan N Pauli

    Full Text Available Promiscuous mating strategies are much more common than previously appreciated. So much so, that several authors have proposed that promiscuity is the "rule" rather than the exception in vertebrate mating systems. Decreasing species mobility and increasing habitat fragmentation have both been suggested to reduce the "polygyny potential" of the environment and promote other mating strategies like promiscuity in females. We explored the social and genetic mating system for one of the most sedentary extant mammals, the brown-throated three-toed sloth (Bradypus variegatus, within a highly fragmented Neotropical habitat. Surprisingly, we found that three-toed sloths were strongly polygynous, with males excluding male competitors from their core ranges, and exhibiting strong reproductive skew. Indeed, only 25% of all resident adult males sired offspring and one individual sired half of all sampled juveniles. Paradoxically, a sedentary life-history strategy seems to facilitate polygyny in fragmented landscapes because multiple females can persist within small patches of habitat, and be monopolized by a single male. Our work demonstrates that strong polygyny can arise in systems in which the polygyny potential should be extremely low, and other strategies, including promiscuity, would be favoured. Mating systems can be influenced by a multitude of factor and are dynamic, varying among taxa, over time, and across habitats; consequently, mating systems remain difficult to predict based on general ecological principles.

  4. Modelling population effects of juvenile offshore fish displacement towards adult habitat

    DEFF Research Database (Denmark)

    van de Wolfshaar, K.E.; Tulp, I.; Wennhage, H.

    2015-01-01

    consequences on population dynamics through changes in resource use and competition. To explore this, a conceptual stage-structured model was developed with 3 stages and 2 resources and allowing a move of large juveniles from the shallow to the deep habitat. Large juveniles compete with small juveniles...... in shallow waters and with adults in deeper waters. Alternative stable states occur, with one state dominated by small juvenile biomass and the other dominated by adult biomass. The model results show for both states that while large juvenile biomass responds to a change in time spent in the deep habitat...

  5. Imaging of juvenile spondyloarthritis. Part I: Classifications and radiographs

    Directory of Open Access Journals (Sweden)

    Iwona Sudoł-Szopińska

    2017-09-01

    Full Text Available Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Conventional radiographs visualize late inflammatory lesions and post-inflammatory complications. Early diagnosis is possible with the use of ultrasonography and magnetic resonance imaging. The first part of the article presents classifications of juvenile spondyloarthropathies and discusses their radiographic presentation. Typical radiographic features of individual types of juvenile spondyloarthritis are listed (including ankylosing spondylitis, juvenile psoriatic arthritis, reactive arthritis and arthritis in the course of inflammatory bowel diseases. The second part will describe changes visible on ultrasonography and magnetic resonance imaging. In patients with juvenile spondyloarthropathies, these examinations are conducted to diagnose inflammatory lesions in peripheral joints, tendon sheaths, tendons and bursae. Moreover, magnetic resonance imaging also visualizes early inflammatory changes in the axial skeleton and subchondral bone marrow edema, which is considered an early sign of inflammation.

  6. Spatial dynamics of juvenile anchovy in the Bay of Biscay

    KAUST Repository

    Boyra, Guillermo

    2016-07-08

    In autumn 2009, the implementation of two successive acoustic surveys targeting juvenile anchovy (Engraulis encrasicolus) in the Bay of Biscay allowed us to monitor the changes in the spatial distribution and aggregation patterns of juveniles of this species during 45 days under fairly stable meteorological conditions. Juvenile anchovy changed its biological condition and behavior in a different manner in two distinct areas. In the Spanish sector, the juveniles migrated 20 nautical miles (n.mi.) towards the coast, but they remained on the shelf and near the surface during the whole surveyed period. As the advance towards the shelf break progressed, their area of distribution decreased, their density increased and the juveniles spread in fewer but heavier shoals. In the French sector, the juveniles also migrated from slope waters towards the coast at a similar velocity, but they crossed the shelf break into the continental shelf, where they increased their mean depth significantly until gradually adopting the typical nyctemeral migrations of adult anchovy. The mean length of the juveniles that adopted the nyctemeral migrations was significantly higher than that of the juveniles remaining at the surface, suggesting that body size is relevant to accomplish this change. Besides, the stronger temperature gradients between the shelf and oceanic waters in the Spanish sector, favored by a narrow shelf, may have acted as a barrier influencing the distinct observed spatial patterns in the two areas. © 2016 John Wiley & Sons Ltd

  7. Spatial dynamics of juvenile anchovy in the Bay of Biscay

    KAUST Repository

    Boyra, Guillermo; Peñ a, Marian; Cotano, Unai; Irigoien, Xabier; Rubio, Anna; Nogueira, Enrique

    2016-01-01

    In autumn 2009, the implementation of two successive acoustic surveys targeting juvenile anchovy (Engraulis encrasicolus) in the Bay of Biscay allowed us to monitor the changes in the spatial distribution and aggregation patterns of juveniles of this species during 45 days under fairly stable meteorological conditions. Juvenile anchovy changed its biological condition and behavior in a different manner in two distinct areas. In the Spanish sector, the juveniles migrated 20 nautical miles (n.mi.) towards the coast, but they remained on the shelf and near the surface during the whole surveyed period. As the advance towards the shelf break progressed, their area of distribution decreased, their density increased and the juveniles spread in fewer but heavier shoals. In the French sector, the juveniles also migrated from slope waters towards the coast at a similar velocity, but they crossed the shelf break into the continental shelf, where they increased their mean depth significantly until gradually adopting the typical nyctemeral migrations of adult anchovy. The mean length of the juveniles that adopted the nyctemeral migrations was significantly higher than that of the juveniles remaining at the surface, suggesting that body size is relevant to accomplish this change. Besides, the stronger temperature gradients between the shelf and oceanic waters in the Spanish sector, favored by a narrow shelf, may have acted as a barrier influencing the distinct observed spatial patterns in the two areas. © 2016 John Wiley & Sons Ltd

  8. Using the Juvenile Justice Poster. Teaching Strategy.

    Science.gov (United States)

    Update on Law-Related Education, 2000

    2000-01-01

    Presents a lesson that can help students review and summarize what they have learned about the juvenile justice system. Explains that the students discuss how the juvenile justice system can be improved and conduct a survey on how it might be changed in the future. Provides a copy of the survey and directions. (CMK)

  9. Reformations in Zimbabwe's juvenile justice system | Ruparanganda ...

    African Journals Online (AJOL)

    Children in conflict with the law are often stigmatized and shunned by society as they are perceived as a threat to society. Historically, Zimbabwe's juvenile justice system has been retributive and focused on punishing the juvenile offender. As a result, it has been criticised from a number of viewpoints, including the need to ...

  10. Juvenile Delinquency and Teenage Pregnancy: A Comparison of Ecological Risk Profiles among Midwestern White and Black Female Juvenile Offenders

    Science.gov (United States)

    Khurana, Atika; Cooksey, Elizabeth C.; Gavazzi, Stephen M.

    2011-01-01

    The authors examined ecological risk factors associated with teen pregnancy with a sample of 1,190 court-involved female juvenile offenders between 11 and 18 years of age. Data were obtained from five Midwestern juvenile county courts using a recently developed youth risk assessment instrument called the global risk assessment device (GRAD). In…

  11. 83 CHALLENGES AND PROSPECTS OF THE JUVENILE JUSTICE ...

    African Journals Online (AJOL)

    Fr. Ikenga

    Juvenile justice administration in Nigeria is weak and has been given very .... The Nigerian criminal justice system, of which the juvenile justice system is an integral part, ... as instruments of security and justice but as weapons of oppression8.

  12. Bilateral, independent juvenile nasopharyngeal angiofibroma: case report.

    Science.gov (United States)

    Mørkenborg, M-L; Frendø, M; Stavngaard, T; Von Buchwald, C

    2015-10-01

    Juvenile nasopharyngeal angiofibroma is a benign, vascular tumour that primarily occurs in adolescent males. Despite its benign nature, aggressive growth patterns can cause potential life-threatening complications. Juvenile nasopharyngeal angiofibroma is normally unilateral, originating from the sphenopalatine artery, but bilateral symptoms can occur if a large tumour extends to the contralateral side of the nasopharynx. This paper presents the first reported case of true bilateral extensive juvenile nasopharyngeal angiofibroma involving clinically challenging pre-surgical planning and surgical strategy. A 21-year-old male presented with increasing bilateral nasal obstruction and discharge. Examination revealed tumours bilaterally and imaging demonstrated non-contiguous tumours. Pre-operative angiography showed strictly ipsilateral vascular supplies requiring bilateral embolisation. Radical removal performed as one-step, computer-assisted functional endoscopic sinus surgery was performed. The follow-up period was uncomplicated. This case illustrates the importance of suspecting bilateral juvenile nasopharyngeal angiofibroma in patients presenting with bilateral symptoms. Our management, including successful pre-operative planning, enabled one-step total removal of both tumours and rapid patient recovery.

  13. Radium rentention and dosimetry in juvenile beagles

    International Nuclear Information System (INIS)

    Lloyd, R.D.; Jones, C.W.; Bruenger, F.W.; Atherton, D.R.; Mays, C.W.

    1983-01-01

    Retention of administered 226 Ra was substantially greater in beagles injected as 3-month-old juveniles than as 1.4-year-old adults, but the measured 222 Rn/ 226 Ra ratio in bone was significantly less in juveniles for about the first 600 days after injection. An equation that describes the total-body biological retention R in beagles injected with 226 Ra at 3 months of age at any time t (in days) after injection during the first 6.6 years is R = 0.331e/sup -0.206t/ + 0.245e/sup -0.00374t/ + 0.424e/sup -0.000114t/. The rate constant of the final term in the equation for juveniles is similar to that for young adults, suggesting that this component reflects the net turnover rate in the slowly remodeling component of adult bone. Compared to young adult beagles, animals injected as juveniles had a greater fraction of their retained 226 Ra in parts of the skeleton containing much cortical bone, such as paws, and a smaller fraction in those parts containing much trabecular bone

  14. Race and the fragility of the legal distinction between juveniles and adults.

    Directory of Open Access Journals (Sweden)

    Aneeta Rattan

    Full Text Available Legal precedent establishes juvenile offenders as inherently less culpable than adult offenders and thus protects juveniles from the most severe of punishments. But how fragile might these protections be? In the present study, simply bringing to mind a Black (vs. White juvenile offender led participants to view juveniles in general as significantly more similar to adults in their inherent culpability and to express more support for severe sentencing. Indeed, these differences in participants' perceptions of this foundational legal precedent distinguishing between juveniles and adults accounted for their greater support for severe punishment. These results highlight the fragility of protections for juveniles when race is in play. Furthermore, we suggest that this fragility may have broad implications for how juveniles are seen and treated in the criminal justice system.

  15. Criminal history and future offending of juveniles convicted of the possession of child pornography.

    Science.gov (United States)

    Aebi, Marcel; Plattner, Belinda; Ernest, Melanie; Kaszynski, Katie; Bessler, Cornelia

    2014-08-01

    Most child pornography is distributed online. It is estimated that 3% to 15% of child pornography consumers are juveniles. The present study analyzed a consecutive sample of 54 male juveniles convicted of the possession of child pornography. Demographic characteristics, criminal history, and subsequent offending were assessed from criminal files and official reports. Juvenile possessors of child pornography were compared to three different groups of juveniles: Juvenile possessors of other illegal pornography (n = 42), juveniles who committed a sexual contact offense against a child (n = 64), and juveniles who committed a sexual contact offense against a peer or adult (n = 104). Juvenile possessors of child pornography were found to have downloaded the illegal material more frequently and over a longer time period than juvenile possessors of other illegal pornography. Furthermore, juvenile possessors of child pornography differed from juveniles who had committed a sexual contact offense in terms of demographics and showed fewer previous and subsequent offending than juveniles who sexually offended against a peer or adult. We conclude that juvenile possessors of child pornography need a specific target intervention focusing on dysfunctional Internet use and sexually deviant arousal. © The Author(s) 2013.

  16. The bioinvasion of Guam: inferring geographic origin, pace, pattern and process of an invasive lizard (Carlia) in the Pacific using multi-locus genomic data

    Science.gov (United States)

    Austin, C.C.; Rittmeyer, E.N.; Oliver, L.A.; Andermann, J.O.; Zug, G.R.; Rodda, G.H.; Jackson, N.D.

    2011-01-01

    Invasive species often have dramatic negative effects that lead to the deterioration and loss of biodiversity frequently coupled with the burden of expensive biocontrol programs and subversion of socioeconomic stability. The fauna and flora of oceanic islands are particularly susceptible to invasive species and the increase of global movements of humans and their products since WW II has caused numerous anthropogenic translocations and increased the ills of human-mediated invasions. We use a multi-locus genomic dataset to identify geographic origin, pace, pattern and historical process of an invasive scincid lizard (Carlia) that has been inadvertently introduced to Guam, the Northern Marianas, and Palau. This lizard is of major importance as its introduction is thought to have assisted in the establishment of the invasive brown treesnake (Boiga irregularis) on Guam by providing a food resource. Our findings demonstrate multiple waves of introductions that appear to be concordant with movements of Allied and Imperial Japanese forces in the Pacific during World War II.

  17. Growth of juvenile shrimp Metapenaeus monoceros fed with squid and mussel

    Digital Repository Service at National Institute of Oceanography (India)

    Achuthankutty, C.T.; Nair, S.R.S.; Krishnakumari, L.

    Small juveniles of both sexes and females of large juveniles of Metapenaeus monoceros attained faster growth with squid diet. Males of large juveniles registered better growth with mussel diet. No significant difference was observed in moult weights...

  18. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.

    2012-01-01

    masses of the brown dwarf companions are 0.02 ± 0.01 M⊙ and 0.019 ± 0.002 M⊙ for MOA-2011-BLG-104/OGLE-2011-BLG-0172 and MOA-2011-BLG-149, respectively, and both companions are orbiting low-mass M dwarf host stars. More microlensing brown dwarfs are expected to be detected as the number of lensing events...

  19. Development of brown coal mining in the Federal Republic of Germany

    Energy Technology Data Exchange (ETDEWEB)

    Tilmann, W

    1985-01-01

    The significance of brown coal mining in the Federal Republic of Germany for the development of opencast technology and the power industry is discussed with emphasis on mining in the Rhineland Area. In 1984, 126.7 mt of brown coal were produced in the Federal Republic of Germany. In the development of high-performance equipment it is essential that the efficiency of the bucket-wheel excavator is increased. Trains and conveyors are mainly used for mine transport in the Federal Republic of Germany. A high moral commitment is linked to land claims, recultivation and environmental issues on the part of brown coal mining. In 1984 the percentage share of brown coal supplied to the public power stations was 83.6%, corresponding to 105.9 mt. The installed capacity of all brown coal power stations amounted to 12,764 MW at the end of 1984, providing around one quarter of overall public power output. Charge coal for coal refining has become more important and the production of brown coal dust and brown coal coke has also increased. The share of brown coal in domestic primary energy production is currently around 24% of 151 mt hard-coal units or around 10% of 376.5 mt hard-coal units in terms of energy consumption. 12 references.

  20. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

    DEFF Research Database (Denmark)

    Barbatelli, G.; Murano, I.; Madsen, Lise

    2010-01-01

    The origin of brown adipocytes arising in white adipose tissue (WAT) after cold acclimatization is unclear. Here, we demonstrate that several UCP1-immunoreactive brown adipocytes occurring in WAT after cold acclimatization have a mixed morphology (paucilocular adipocytes). These cells also had a ...

  1. Explaining millimeter-sized particles in brown dwarf disks

    NARCIS (Netherlands)

    Pinilla, P.; Birnstiel, T.; Benisty, M.; Ricci, L.; Natta, A.; Dullemond, C.P.; Dominik, C.; Testi, L.

    2013-01-01

    Context. Planets have been detected around a variety of stars, including low-mass objects, such as brown dwarfs. However, such extreme cases are challenging for planet formation models. Recent sub-millimeter observations of disks around brown dwarf measured low spectral indices of the continuum

  2. Juvenile technologies in foreign publications

    Directory of Open Access Journals (Sweden)

    Shpagina E.M.

    2012-09-01

    Full Text Available The article provides the review of foreign publications, concerning the juvenile technologies used in France, Canada, Germany and Switzerland. The paper presents legal, social and psychotherapeutic aspects of juvenile judiciary in foreign countries. The authors paid special attention to the complexity of approaches to young children and teenagers who found themselves in complicated life circumstances or got into trouble with the law. The article gives examples of using the following techniques: cognitive-behavioral intervention, mediation, family therapy (including family background and family history, relations theory, narrative practices, utilization of «emotional intelligence» resources.

  3. CASE REPORT PET/CT-positive brown tumour – a potentially ...

    African Journals Online (AJOL)

    Brown tumor of bone: a potential source of false-positive Thallium-201 localization. J Nucl Med 1989; 30: 1264-1267. 4. Nassar GM, Ayus JC. Images in clinical medicine. Brown tumor in end stage renal disease. N Engl J Med. 1999; 341: 1652. 5. Keyser JS, Postma GN. Brown tumor of the mandible. Am J Otolaryngol 1996; ...

  4. After Brown U.'s Report on Slavery, Silence (So Far)

    Science.gov (United States)

    Bartlett, Thomas

    2006-01-01

    This article, discusses Brown University's slavery report, a 106-page narrative examination of the early connections between Brown University and slavery, that has been greeted--so far--with silence. The report, done at the behest of Ruth J. Simmons, Brown's president and herself a descendant of slaves, is an unsparing look at a shameful side of…

  5. Corporal and capital punishment of juveniles.

    Science.gov (United States)

    Frazier, H C

    1990-01-01

    There is a previously unobserved connection between corporal punishment of public school children and capital punishment of juveniles. Both are barometers of acceptable levels of violent punishment and their elimination is a hallmark of a maturing and decent society. Within a majority of the eighteen states where school authorities most frequently strike children are housed 25 of the nation's 28 juvenile death row inmates. On average, the homicide rates of these jurisdictions are two and a half times greater than those that have abolished both state-sanctioned corporal and capital punishment or limit death sentences to those age eighteen and older at the time of their crime(s). Most of the eighteen state abolitions of corporal punishment occurred in the 1980's. The US Supreme Court has ruled both corporal and capital punishment of juveniles constitutional. Additional state legislative abolition of both is anticipated in the 1990s.

  6. The membrane may be an important factor in browning of fresh-cut pear.

    Science.gov (United States)

    Li, Zhenghong; Zhang, Yuxing; Ge, Huibo

    2017-09-01

    Surface browning is an important cause of deterioration of fresh-cut fruit during postharvest handling. In this paper, four pear cultivars with different extents of natural browning were selected to analyse the factors involved in browning. The main results are as follows: the lipoxygenase (LOX) activity of 'Mantianhong' and 'Yali' pears was higher accompanied by a stronger degree of browning, while the LOX activity in 'Xueqing' and 'Xinli 7' pears was lower, with less browning. A higher unsaturated fatty acid ratio of pear resulted in reduced browning. The cell membranes disappeared 30min after being cut in 'Mantianhong' pear, which browns easily; however, the cell membranes were still intact 30min after being cut in 'Xueqing' pear, which does not brown easily. Therefore, it can be assumed that the stability of the cell membrane plays an important role in inhibiting browning of fresh-cut pears. Copyright © 2017. Published by Elsevier Ltd.

  7. Browning and graying: novel transcriptional regulators of brown and beige fat tissues and aging

    Directory of Open Access Journals (Sweden)

    Elisabetta eMueller

    2016-03-01

    Full Text Available Obesity represents a major risk factor for the development of a number of metabolic disorders, including cardiovascular disease and type 2 diabetes. Since the discovery that brown and beige fat cells exist in adult humans and contribute to energy expenditure, increasing interest has been devoted to the understanding of the molecular switches turning on calorie utilization. It has been reported that the ability of thermogenic tissues to burn energy declines during aging, possibly contributing to the development of metabolic dysfunction late in life. This review will focus on the recently identified transcriptional modulators of brown and beige cells and will discuss the potential impact of some of these thermogenic factors on age-associated metabolic disorders.

  8. Phospholipids of New Zealand Edible Brown Algae.

    Science.gov (United States)

    Vyssotski, Mikhail; Lagutin, Kirill; MacKenzie, Andrew; Mitchell, Kevin; Scott, Dawn

    2017-07-01

    Edible brown algae have attracted interest as a source of beneficial allenic carotenoid fucoxanthin, and glyco- and phospholipids enriched in polyunsaturated fatty acids. Unlike green algae, brown algae contain no or little phosphatidylserine, possessing an unusual aminophospholipid, phosphatidyl-O-[N-(2-hydroxyethyl) glycine], PHEG, instead. When our routinely used technique of 31 P-NMR analysis of phospholipids was applied to the samples of edible New Zealand brown algae, a number of signals corresponding to unidentified phosphorus-containing compounds were observed in total lipids. NI (negative ion) ESI QToF MS spectra confirmed the presence of more familiar phospholipids, and also suggested the presence of PHEG or its isomers. The structure of PHEG was confirmed by comparison with a synthetic standard. An unusual MS fragmentation pattern that was also observed prompted us to synthesise a number of possible candidates, and was found to follow that of phosphatidylhydroxyethyl methylcarbamate, likely an extraction artefact. An unexpected outcome was the finding of ceramidephosphoinositol that has not been reported previously as occurring in brown algae. An uncommon arsenic-containing phospholipid has also been observed and quantified, and its TLC behaviour studied, along with that of the newly synthesised lipids.

  9. Investigation of metal ions sorption of brown peat moss powder

    Science.gov (United States)

    Kelus, Nadezhda; Blokhina, Elena; Novikov, Dmitry; Novikova, Yaroslavna; Chuchalin, Vladimir

    2017-11-01

    For regularities research of sorptive extraction of heavy metal ions by cellulose and its derivates from aquatic solution of electrolytes it is necessary to find possible mechanism of sorption process and to choice a model describing this process. The present article investigates the regularities of aliovalent metals sorption on brown peat moss powder. The results show that sorption isotherm of Al3+ ions is described by Freundlich isotherm and sorption isotherms of Na+ i Ni2+ are described by Langmuir isotherm. To identify the mechanisms of brown peat moss powder sorption the IR-spectra of the initial brown peat moss powder samples and brown peat moss powder samples after Ni (II) sorption were studied. Metal ion binding mechanisms by brown peat moss powder points to ion exchange, physical adsorption, and complex formation with hydroxyl and carboxyl groups.

  10. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

    DEFF Research Database (Denmark)

    Hiraike, Yuta; Waki, Hironori; Yu, Jing

    2017-01-01

    . NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific enhancers. Moreover, the binding of NFIA precedes and facilitates the binding of PPARγ, leading to increased chromatin accessibility and active transcription. Introduction of NFIA into myoblasts...... results in brown adipocyte differentiation. Conversely, the brown fat of NFIA-knockout mice displays impaired expression of the brown-fat-specific genes and reciprocal elevation of muscle genes. Finally, expression of NFIA and the brown-fat-specific genes is positively correlated in human brown fat...

  11. 28 CFR 0.94 - Office of Juvenile Justice and Delinquency Prevention.

    Science.gov (United States)

    2010-07-01

    ... Delinquency Prevention. 0.94 Section 0.94 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE... Delinquency Prevention. The Office of Juvenile Justice and Delinquency Prevention is headed by an...., relating to juvenile delinquency, the improvement of juvenile justice systems and missing children. ...

  12. Inhibition of Enzymatic Browning of Chlorogenic Acid by Sulfur-Containing Compounds

    NARCIS (Netherlands)

    Kuijpers, T.F.M.; Narvaez Cuenca, C.E.; Vincken, J.P.; Verloop, J.W.; Berkel, van W.J.H.; Gruppen, H.

    2012-01-01

    The antibrowning activity of sodium hydrogen sulfite (NaHSO3) was compared to that of other sulfur-containing compounds. Inhibition of enzymatic browning was investigated using a model browning system consisting of mushroom tyrosinase and chlorogenic acid (5-CQA). Development of brown color

  13. Parental Low Self-Control, Family Environments, and Juvenile Delinquency.

    Science.gov (United States)

    Meldrum, Ryan C; Connolly, George M; Flexon, Jamie; Guerette, Rob T

    2016-10-01

    Research consistently finds that low self-control is significantly correlated with delinquency. Only recently, however, have researchers started to examine associations between parental low self-control, family environments, and child antisocial behavior. Adding to this emerging area of research, the current study examines associations between parental low self-control, aspects of the family environment, and officially recoded juvenile delinquency among a sample (N = 101) of juveniles processed through a juvenile justice assessment facility located in the Southeastern United States. Furthermore, it considers whether aspects of family environments, particularly family cohesion, family conflict, and parental efficacy, mediate the influence of parental low self-control on delinquency. The results of a series of analyses indicate that parental low self-control is correlated with various aspects of family environments and juvenile delinquency, and that the association between parental low self-control and juvenile delinquency is mediated by family environments. Supplementary analyses also suggest that the association between parental low self-control and the family environment may be reciprocal. © The Author(s) 2015.

  14. Temperament of juvenile delinquents with history of substance abuse.

    Science.gov (United States)

    Chang, Hsueh-Ling; Chen, Sue-Huei; Huang, Chien

    2007-01-01

    The etiological factors and interrelations of juvenile delinquents, with psychiatric morbidity and substance abuse have been continuously debated. Cloninger's Tridimensional Theory of Temperament has been reported to predict patterns of substance abuse and comorbidity. In the current study, we aimed to examine the usability of the theory in predicting juvenile delinquency and substance abuse. Sixty consecutive and newly incarcerated male delinquents with history of substance abuse were recruited from a juvenile correctional facility in northwestern Taiwan from January 2002 through December 2003. All subjects were assessed of their temperament, behavioral problems, and psychiatric disorders on an individual base. The juvenile delinquent subjects with childhood history of attention deficit and hyperactivity disorder (ADHD) were significantly younger, consumed less betel nuts, and had more siblings with history of drug abuse. Consistent with the results of Cloninger's studies, novelty seeking positively correlated to the amount of substance abuse, while harm avoidance inversely correlated in juvenile delinquents. Endemic trend of choice of substance abuse needs to be taken into consideration in future research projects.

  15. Maxillary brown tumor as initial presentation of parathyroid adenoma: A case report

    Directory of Open Access Journals (Sweden)

    Hon-Ke Sia

    2012-07-01

    Full Text Available Brown tumor is a rare late-stage skeletal change caused by long-term stimulation of excess parathyroid hormone. It is not neoplastic, but a reparative cellular process. Common sites of brown tumor are the ribs, clavicle, long bones and pelvic girdle. Solitary maxillary brown tumor as initial presentation of primary hyperparathyroidism is rare; it is often accompanied by brown tumors of the other facial bones. Here, we present the first case of solitary maxillary brown tumor in a 29-year-old ethnic Chinese woman with initial presentation of a large tumor filling the left maxillary sinus. Underlying long-standing primary hyperparathyroidism caused by a large parathyroid adenoma was finally diagnosed. Brown tumor tends to be misdiagnosed as malignancy, and delayed diagnosis of the underlying hyperparathyroidism is common. Our case validates the suggestion that young women have a higher probability of brown tumor. Biopsy of the suspicious bone tumor and blood tests for calcium and parathyroid hormone level are crucial and essential to reach the correct diagnosis. Most brown tumors show spontaneous regression after parathyroidectomy. However, direct excision of the brown tumor may be indicated to avoid the risk of facial deformity and orbital compression at a special anatomical site, as in our case.

  16. Prevention and Firesetting: Juvenile Justice and Intervention Strategies.

    Science.gov (United States)

    Slavkin, Michael L.

    2003-01-01

    Examines the literature on preventing firesetting behavior in preadolescents and adolescents, suggesting the need for policies and programs designed to help juveniles by providing community support and stability. Alternatives to juvenile justice interventions include making changes in the home environment, acquiring a greater sense of self, and…

  17. Dental and facial characteristics of patients with juvenile idiopathic arthritis Características dentárias e faciais de pacientes com artrite idiopática juvenil

    Directory of Open Access Journals (Sweden)

    Cynthia Savioli

    2004-01-01

    Full Text Available OBJECTIVE: It has been shown that the temporomandibular joint is frequently affected by juvenile idiopathic arthritis, and this degenerative disease, which may occur during facial growth, results in severe mandibular dysfunction. However, there are no studies that correlate oral health (tooth decay and gingival diseases and temporomandibular joint dysfunction in patients with juvenile idiopathic arthritis. The aim of this study is to evaluate the oral and facial characteristics of the patients with juvenile idiopathic arthritis treated in a large teaching hospital. METHOD: Thirty-six patients with juvenile idiopathic arthritis (26 female and 10 male underwent a systematic clinical evaluation of their dental, oral, and facial structures (DMFT index, plaque and gingival bleeding index, dental relationship, facial profile, and Helkimo's index. The control group was composed of 13 healthy children. RESULTS: The mean age of the patients with juvenile idiopathic arthritis was 10.8 years; convex facial profile was present in 12 juvenile idiopathic arthritis patients, and class II molar relation was present in 12 (P = .032. The indexes of plaque and gingival bleeding were significant in juvenile idiopathic arthritis patients with a higher number of superior limbs joints involved (P = .055. Anterior open bite (5 and temporomandibular joint noise (8 were present in the juvenile idiopathic arthritis group. Of the group in this sample, 94% (P = .017 had temporomandibular joint dysfunction, 80% had decreased mandibular opening (P = 0.0002, and mandibular mobility was severely impaired in 33% (P = .015. CONCLUSION: This study confirms that patients with juvenile idiopathic arthritis a have a high incidence of mandibular dysfunction that can be attributed to the direct effect of the disease in the temporomandibular joint and b have a higher incidence of gingival disease that can be considered a secondary effect of juvenile idiopathic arthritis on oral health

  18. Modes of competition: adding and removing brown trout in the wild to understand the mechanisms of density-dependence.

    Directory of Open Access Journals (Sweden)

    Rasmus Kaspersson

    Full Text Available While the prevalence of density-dependence is well-established in population ecology, few field studies have investigated its underlying mechanisms and their relative population-level importance. Here, we address these issues, and more specifically, how differences in body-size influence population regulation. For this purpose, two experiments were performed in a small coastal stream on the Swedish west coast, using juvenile brown trout (Salmo trutta as a study species. We manipulated densities of large and small individuals, and observed effects on survival, migration, condition and individual growth rate in a target group of intermediate-sized individuals. The generality of the response was investigated by reducing population densities below and increasing above the natural levels (removing and adding large and small individuals. Reducing the density (relaxing the intensity of competition had no influence on the response variables, suggesting that stream productivity was not a limiting factor at natural population density. Addition of large individuals resulted in a negative density-dependent response, while no effect was detected when adding small individuals or when maintaining the natural population structure. We found that the density-dependent response was revealed as reduced growth rate rather than increased mortality and movement, an effect that may arise from exclusion to suboptimal habitats or increased stress levels among inferior individuals. Our findings confirm the notion of interference competition as the primary mode of competition in juvenile salmonids, and also show that the feedback-mechanisms of density-dependence are primarily acting when increasing densities above their natural levels.

  19. Neurofibromatosis Type 1 Diagnosed in a Child Based on Multiple Juvenile Xanthogranulomas and Juvenile Myelomonocytic Leukemia

    DEFF Research Database (Denmark)

    Jans, Sune R R; Schomerus, Eckhard; Bygum, Anette

    2015-01-01

    An association between juvenile xanthogranuloma (JXG), neurofibromatosis type 1 (NF1), and juvenile myelomonocytic leukemia (JMML) has been described in the literature but has only been documented in approximately 20 cases. We diagnosed a patient with NF1 at 25 months of age, before any cutaneous...... with chemotherapy and allogenic bone marrow transplantation. With increased awareness, patients with JXG and NF1 who develop symptoms possibly related to JMML, such as paleness, skin bleeding, cough, unexplained fever, and hepatosplenomegaly, should be further evaluated. We also emphasize that multiple JXG lesions...

  20. Obituary: Beth Brown (1969-2008)

    Science.gov (United States)

    Bregman, Joel

    2011-12-01

    The astronomical community lost one of its most buoyant and caring individuals when Beth Brown died, unexpectedly, at the age of 39 from a pulmonary embolism. Beth Brown was born in Roanoke, Virginia where she developed a deep interest in astronomy, science, and science fiction (Star Trek). After graduating as the valedictorian of William Fleming High School's Class of 1987, she attended Howard University, where she graduated summa cum laude in 1991 with a bachelor's degree in astrophysics. Following a year in the graduate physics program at Howard, she entered the graduate program in the Department of Astronomy at the University of Michigan, the first African-American woman in the program. She received her PhD in 1998, working with X-ray observations of elliptical galaxies from the Röntgen Satellite (ROSAT; Joel Bregman was her advisor). She compiled and analyzed the first large complete sample of such galaxies with ROSAT and her papers in this area made an impact in the field. Following her PhD, Beth Brown held a National Academy of Science & National Research Council Postdoctoral Research Fellowship at NASA's Goddard Space Flight Center. Subsequently, she became a civil servant at the National Space Science Data Center at GSFC, where she was involved in data archival activities as well as education and outreach, a continuing passion in her life. In 2006, Brown became an Astrophysics Fellow at GSFC, during which time she worked as a visiting Assistant Professor at Howard University, where she taught and worked with students and faculty to improve the teaching observatory. At the time of her death, she was eagerly looking forward to a new position at GSFC as the Assistant Director for Science Communications and Higher Education. Beth Brown was a joyous individual who loved to work with people, especially in educating them about our remarkable field. Her warmth and openness was a great aid in making accessible explanations of otherwise daunting astrophysical

  1. Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.

    Science.gov (United States)

    Kriszt, Rókus; Arai, Satoshi; Itoh, Hideki; Lee, Michelle H; Goralczyk, Anna G; Ang, Xiu Min; Cypess, Aaron M; White, Andrew P; Shamsi, Farnaz; Xue, Ruidan; Lee, Jung Yeol; Lee, Sung-Chan; Hou, Yanyan; Kitaguchi, Tetsuya; Sudhaharan, Thankiah; Ishiwata, Shin'ichi; Lane, E Birgitte; Chang, Young-Tae; Tseng, Yu-Hua; Suzuki, Madoka; Raghunath, Michael

    2017-05-03

    The identification of brown adipose deposits in adults has led to significant interest in targeting this metabolically active tissue for treatment of obesity and diabetes. Improved methods for the direct measurement of heat production as the signature function of brown adipocytes (BAs), particularly at the single cell level, would be of substantial benefit to these ongoing efforts. Here, we report the first application of a small molecule-type thermosensitive fluorescent dye, ERthermAC, to monitor thermogenesis in BAs derived from murine brown fat precursors and in human brown fat cells differentiated from human neck brown preadipocytes. ERthermAC accumulated in the endoplasmic reticulum of BAs and displayed a marked change in fluorescence intensity in response to adrenergic stimulation of cells, which corresponded to temperature change. ERthermAC fluorescence intensity profiles were congruent with mitochondrial depolarisation events visualised by the JC-1 probe. Moreover, the averaged fluorescence intensity changes across a population of cells correlated well with dynamic changes such as thermal power, oxygen consumption, and extracellular acidification rates. These findings suggest ERthermAC as a promising new tool for studying thermogenic function in brown adipocytes of both murine and human origins.

  2. Uveíte na artrite idiopática juvenil Uveitis in juvenile idiopathic arthritis

    Directory of Open Access Journals (Sweden)

    Adriana M. Roberto

    2002-02-01

    Full Text Available Objetivo: avaliar a freqüência de uveíte anterior crônica em pacientes com artrite idiopática juvenil (AIJ e sua associação com a presença do fator antinúcleo (FAN. Casuística e métodos: foram avaliadas, retrospectivamente, 72 crianças com diagnóstico confirmado de AIJ, que tiveram avaliação oftalmológica através da biomicroscopia para exame da câmara anterior da úvea, determinação do FAN (imunofluorescência indireta e fator reumatóide (FR (prova do látex no período inicial da doença. Para os pacientes com FAN positivo, esta avaliação foi realizada a cada três meses, e, caso contrário, a cada seis meses.Resultados: dos 72 pacientes com AIJ, 40 (55,5% crianças eram do sexo masculino e 36 (50% caucasóides. A idade média de início da AIJ foi 6,4 anos (1 a 14 anos, e a idade média na época do estudo foi de 10,4 anos (1 a 19 anos. De acordo com o tipo de início da AIJ, em 32 (44,4% crianças era pauciarticular (17 meninos e 15 meninas, em 30 (41,6% era poliarticular (17 meninos e 13 meninas, e em 10 (14% era sistêmico (6 meninos e 4 meninas. A presença de uveíte anterior crônica foi detectada em cinco (6,5% crianças com idade média de 11,4 anos. Destas, quatro (80% eram do tipo de início pauciarticular (três meninas do tipo I, com FAN positivo, e um menino do tipo I, FAN negativo, e uma menina com doença poliarticular (FAN e FR negativos. Neste grupo, a idade de início da AIJ foi em média 5,1 anos (3 a 12 anos, e a idade de início da uveíte foi em média de 9 anos (4 a 16 anos. O FAN foi positivo em 3/5 pacientes (60% com uveíte. Dentre os pacientes com AIJ e sem uveíte (67 crianças, oito (12% apresentaram FAN positivo. Quanto à evolução dos pacientes com comprometimento ocular, três crianças tiveram apenas um episódio de uveíte, e duas crianças apresentaram quatro recorrências da uveíte com catarata sem atividade articular associada. A presença do FAN foi estatisticamente mais freq

  3. Juvenile Rockfish Recruitment Cruise

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In 1983, the groundfish analysis project began a series of yearly cruises designed to assess the annual abundance of juvenile rockfish along the central California...

  4. Psychotic Symptomatology in a Juvenile Court Clinic Population

    Science.gov (United States)

    Lewis, Dorothy Otnow; And Others

    1973-01-01

    This report indicating an unexpectedly high incidence of psychotic symptomatology in a population of cases referred to the Juvenile Court Psychiatric Clinic of the Second District of Connecticut, manifests the necessity for juvenile court systems to be made aware of the possibility of psychosis in our delinquent populations. (CS)

  5. Global transcriptomic profiling demonstrates induction of oxidative stress and of compensatory cellular stress responses in brown trout exposed to glyphosate and Roundup.

    Science.gov (United States)

    Uren Webster, Tamsyn M; Santos, Eduarda M

    2015-01-31

    Glyphosate, the active ingredient in Roundup formulations, is the most widely used herbicide worldwide, and as a result contaminates surface waters and has been detected in food residues, drinking water and human urine, raising concerns for potential environmental and human health impacts. Research has shown that glyphosate and Roundup can induce a broad range of biological effects in exposed organisms, particularly via generation of oxidative stress. However, there has been no comprehensive investigation of the global molecular mechanisms of toxicity of glyphosate and Roundup for any species. We aimed to characterise and compare the global mechanisms of toxicity of glyphosate and Roundup in the liver of brown trout (Salmo trutta), an ecologically and economically important vertebrate species, using RNA-seq on an Illumina HiSeq 2500 platform. To do this, we exposed juvenile female brown trout to 0, 0.01, 0.5 and 10 mg/L of glyphosate and Roundup (glyphosate acid equivalent) for 14 days, and sequenced 6 replicate liver samples from each treatment. We assembled the brown trout transcriptome using an optimised de novo approach, and subsequent differential expression analysis identified a total of 1020 differentially-regulated transcripts across all treatments. These included transcripts encoding components of the antioxidant system, a number of stress-response proteins and pro-apoptotic signalling molecules. Functional analysis also revealed over-representation of pathways involved in regulating of cell-proliferation and turnover, and up-regulation of energy metabolism and other metabolic processes. These transcriptional changes are consistent with generation of oxidative stress and the widespread induction of compensatory cellular stress response pathways. The mechanisms of toxicity identified were similar across both glyphosate and Roundup treatments, including for environmentally relevant concentrations. The significant alterations in transcript expression observed

  6. Molecular Selectivity of Brown Carbon Chromophores

    Energy Technology Data Exchange (ETDEWEB)

    Laskin, Julia; Laskin, Alexander; Nizkorodov, Sergey; Roach, Patrick J.; Eckert, Peter A.; Gilles, Mary K.; Wang, Bingbing; Lee, Hyun Ji; Hu, Qichi

    2014-10-21

    Complementary methods of high-resolution mass spectrometry and micro-spectroscopy were utilized for molecular analysis of secondary organic aerosol (SOA) generated from ozonolysis of two structural monoterpene isomers: D-limonene (LSOA) and a-pinene (PSOA). Laboratory simulated aging of LSOA and PSOA, through conversion of carbonyls into imines mediated by NH3 vapors in humid air, resulted in selective browning of the LSOA sample, while the PSOA sample remained white. Comparative analysis of the reaction products in the aged LSOA and PSOA samples provided insights into chemistry relevant to formation of brown carbon chromophores. A significant fraction of carbonyl-imine conversion products with identical molecular formulas were detected in both samples. This reflects the high level of similarity in the molecular composition of these two closely related SOA materials. Several highly conjugated products were detected exclusively in the brown LSOA sample and were identified as potential chromophores responsible for the observed color change. The majority of the unique products in the aged LSOA sample with the highest number of double bonds contain two nitrogen atoms. We conclude that chromophores characteristic of the carbonyl- imine chemistry in LSOA are highly conjugated oligomers of secondary imines (Schiff bases) present at relatively low concentrations. Formation of this type of conjugated compounds in PSOA is hindered by the structural rigidity of the a-pinene oxidation products. Our results suggest that the overall light-absorbing properties of SOA may be determined by trace amounts of strong brown carbon chromophores.

  7. Juvenile life stages of the brown alga Fucus serratus L. are more sensitive to combined stress from high copper concentration and temperature than adults

    DEFF Research Database (Denmark)

    Nielsen, Søren Laurentius; Nielsen, Hanne Dalsgaard; Pedersen, Morten Foldager

    2014-01-01

    of high copper concentration was amplified by high temperature. We conclude that juveniles of F. serratus are more susceptible to environmental stressors than adult specimens and recommend therefore including early life stages when assessing the risk of exposure to toxic compounds. Considering...... the response of adult specimens only may lead to false conclusions regarding the ecological impact of environmental stress...

  8. Effects of Prior Experience on Shelter-Seeking Behavior of Juvenile American Lobsters.

    Science.gov (United States)

    Bayer, Skylar R; Bianchi, Katherine M; Atema, Jelle; Jacobs, Molly W

    2017-04-01

    Shelter-seeking behaviors are vital for survival for a range of juvenile benthic organisms. These behaviors may be innate or they may be affected by prior experience. After hatching, American lobsters Homarus americanus likely first come into contact with shelter during the late postlarval (decapodid) stage, known as stage IV. After the subsequent molt to the first juvenile stage (stage V), they are entirely benthic and are thought to be highly cryptic. We hypothesized that postlarval (stage IV) experience with shelter would carry over into the first juvenile stage (stage V) and reduce the time needed for juveniles to locate and enter shelters (sheltering). We found some evidence of a carryover effect, but not the one we predicted: stage V juveniles with postlarval shelter experience took significantly longer to initiate sheltering. We also hypothesized that stage V juveniles would demonstrate learning by relocating shelters more quickly with immediate prior experience. Our findings were mixed. In a maze, juveniles with immediate prior experience were faster to regain visual contact with shelter, suggesting that they had learned the location of the shelter. In contrast, there was no significant effect of immediate prior experience on time to initiate sheltering in an open arena, or in the maze after juveniles had regained visual contact. We conclude that very young (stage V) juvenile lobsters modify their shelter-seeking behavior based on prior experiences across several timescales. Ecologically relevant variation in habitat exposure among postlarval and early juvenile lobsters may influence successful recruitment in this culturally and commercially important fishery species.

  9. The Education of Juveniles in Detention: Policy Considerations and Infrastructure Development

    Science.gov (United States)

    Geib, Catherine Foley; Chapman, John F.; D'Amaddio, Amy H.; Grigorenko, Elena L.

    2011-01-01

    This article presents a discussion of the state of affairs pertaining to educating juvenile justice-involved youth. It summarizes general observations regarding the schooling of juveniles in pre-trial and post-trial incarceration settings, as well as, juveniles on probation or in community settings. The article selectively presents relevant…

  10. Juvenile myelomonocytic leukemia presenting as bilateral breast masses

    Energy Technology Data Exchange (ETDEWEB)

    Edison, Michele N.; Letter, Haley P. [Florida Hospital, Department of Radiology, Orlando, FL (United States); University of Central Florida, College of Medicine, Orlando, FL (United States); O' Dell, M.C. [University of Central Florida, College of Medicine, Orlando, FL (United States); Children' s Hospital of Philadelphia, Pediatric Radiology, Philadelphia, PA (United States); Scherer, Kurt; Williams, Jennifer L. [Florida Hospital, Department of Radiology, Orlando, FL (United States); University of Central Florida, College of Medicine, Orlando, FL (United States); Florida State University, College of Medicine, Tallahassee, FL (United States)

    2017-01-15

    An 8-year-old girl presented with bilateral breast masses and was subsequently diagnosed with juvenile myelomonocytic leukemia. Juvenile myelomonocytic leukemia is a rare myelodysplastic syndrome that typically presents in boys younger than 3 years of age with splenomegaly, lymphadenopathy and skin findings. Bilateral breast masses in a child are rare and, as such, present a diagnostic dilemma due to the relative paucity of cases in the literature. We present a case of granulocytic sarcoma of the breasts in a patient with juvenile myelomonocytic leukemia. The authors hope that increased reporting and research regarding pediatric breast masses will help create awareness for such cases. (orig.)

  11. Clinical research of juvenile hyperthyroidism treatment with radioiodine

    International Nuclear Information System (INIS)

    Qiu Ling; Zhang Chunying; Chen Yue

    2001-01-01

    Objective: To evaluate the effects and side effects in the radioiodine management of juvenile hyperthyroidism. Methods: 80 patients with poor effects using anti-thyroid drug were assigned to receive 131 I therapy. The follows of therapy outcome were assessed 1, 3, 6 and 12 months after the start of treatment. One follows up per 1-3 years. Results: Among 80 patients followed by 6 months, clinical response was excellent in 65 patients (81%), good in 15 (19%). There were 12 patients with hypothyroidism followed 4 years, and with no other side effects. Conclusion: The good therapeutic effect was obtained in radioiodine treatment for juvenile hyperthyroidism. Radioiodine was effective to juvenile hyperthyroidism

  12. Juvenile myelomonocytic leukemia presenting as bilateral breast masses

    International Nuclear Information System (INIS)

    Edison, Michele N.; Letter, Haley P.; O'Dell, M.C.; Scherer, Kurt; Williams, Jennifer L.

    2017-01-01

    An 8-year-old girl presented with bilateral breast masses and was subsequently diagnosed with juvenile myelomonocytic leukemia. Juvenile myelomonocytic leukemia is a rare myelodysplastic syndrome that typically presents in boys younger than 3 years of age with splenomegaly, lymphadenopathy and skin findings. Bilateral breast masses in a child are rare and, as such, present a diagnostic dilemma due to the relative paucity of cases in the literature. We present a case of granulocytic sarcoma of the breasts in a patient with juvenile myelomonocytic leukemia. The authors hope that increased reporting and research regarding pediatric breast masses will help create awareness for such cases. (orig.)

  13. A social work study on family related issues influencing juvenile delinquency

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Iravani

    2013-07-01

    Full Text Available We present a study to investigate the impacts of various factors on juvenile delinquency. The study distributes 400 questionnaires among young people aged 19-26 who are involved with some sort of crime and analyzes their feedbacks. There are three hypotheses including family income, tendency to spirituality and religion and educational backgrounds of families and juvenile delinquency among these people. The results show that while family income and religious as well as spirituality characteristics play important role on juvenile delinquency, educational background of the parents do not statistically have any influence on juvenile delinquency. The study recommends that a better family condition could contribute society to reduce juvenile delinquency and people could guide their children through better consultations.

  14. Briquetting of Coke-Brown Coal Mixture

    Directory of Open Access Journals (Sweden)

    Ïurove Juraj

    1998-09-01

    Full Text Available The paper presents the results of the research of briquetting a coke-brown coal composite The operation consists of the feeding crushed coal and coke to moulds and pressing into briquettes which have been made in the Laboratories at the Mining Faculty of Technical University of Košice (Slovakia. In this research, all demands will be analyzed including the different aspects of the mechanical quality of briquettes, the proportion of fine pulverulent coal and coke in bricks, the requirements for briquetting the coke-brown coal materials.

  15. Top-of-atmosphere radiative forcing affected by brown carbon in the upper troposphere

    Science.gov (United States)

    Zhang, Yuzhong; Forrister, Haviland; Liu, Jiumeng; Dibb, Jack; Anderson, Bruce; Schwarz, Joshua P.; Perring, Anne E.; Jimenez, Jose L.; Campuzano-Jost, Pedro; Wang, Yuhang; Nenes, Athanasios; Weber, Rodney J.

    2017-07-01

    Carbonaceous aerosols affect the global radiative balance by absorbing and scattering radiation, which leads to warming or cooling of the atmosphere, respectively. Black carbon is the main light-absorbing component. A portion of the organic aerosol known as brown carbon also absorbs light. The climate sensitivity to absorbing aerosols rapidly increases with altitude, but brown carbon measurements are limited in the upper troposphere. Here we present aircraft observations of vertical aerosol distributions over the continental United States in May and June 2012 to show that light-absorbing brown carbon is prevalent in the troposphere, and absorbs more short-wavelength radiation than black carbon at altitudes between 5 and 12 km. We find that brown carbon is transported to these altitudes by deep convection, and that in-cloud heterogeneous processing may produce brown carbon. Radiative transfer calculations suggest that brown carbon accounts for about 24% of combined black and brown carbon warming effect at the tropopause. Roughly two-thirds of the estimated brown carbon forcing occurs above 5 km, although most brown carbon is found below 5 km. The highest radiative absorption occurred during an event that ingested a wildfire plume. We conclude that high-altitude brown carbon from biomass burning is an unappreciated component of climate forcing.

  16. Catch rate of juveniles Ethamatosa fimbriata , Sardinella maderensis ...

    African Journals Online (AJOL)

    We collected data on the quantity of juvenile fish and the daily duration of fishing trips in four landing sites over a two-week period Bernoulli random variables and properties of uniform distribution were used to analyze the data. Catch rates of juveniles Ethamatosa fimbriata, Sardinella maderensis, and Brachydeuterus ...

  17. Extinguishing All Hope: Life-without-Parole for Juveniles

    Science.gov (United States)

    Butler, Frank

    2010-01-01

    Sentencing juveniles to life-without-parole (JLWOP) is a practice fraught with ethical dilemmas. Through in-depth interviews with 11 men living sentences of JLWOP, their narratives of their backgrounds and experiences as juveniles were studied. Common themes were identified, and 3 general categories of cases emerged from the narratives. Ethical…

  18. Effects of White Rice, Brown Rice and Germinated Brown Rice on Antioxidant Status of Type 2 Diabetic Rats

    OpenAIRE

    Imam, Mustapha Umar; Musa, Siti Nor Asma; Azmi, Nur Hanisah; Ismail, Maznah

    2012-01-01

    Oxidative stress is implicated in the pathogenesis of diabetic complications, and can be increased by diet like white rice (WR). Though brown rice (BR) and germinated brown rice (GBR) have high antioxidant potentials as a result of their bioactive compounds, reports of their effects on oxidative stress-related conditions such as type 2 diabetes are lacking. We hypothesized therefore that if BR and GBR were to improve antioxidant status, they would be better for rice consuming populations inst...

  19. Setting a minimum age for juvenile justice jurisdiction in California.

    Science.gov (United States)

    S Barnert, Elizabeth; S Abrams, Laura; Maxson, Cheryl; Gase, Lauren; Soung, Patricia; Carroll, Paul; Bath, Eraka

    2017-03-13

    Purpose Despite the existence of minimum age laws for juvenile justice jurisdiction in 18 US states, California has no explicit law that protects children (i.e. youth less than 12 years old) from being processed in the juvenile justice system. In the absence of a minimum age law, California lags behind other states and international practice and standards. The paper aims to discuss these issues. Design/methodology/approach In this policy brief, academics across the University of California campuses examine current evidence, theory, and policy related to the minimum age of juvenile justice jurisdiction. Findings Existing evidence suggests that children lack the cognitive maturity to comprehend or benefit from formal juvenile justice processing, and diverting children from the system altogether is likely to be more beneficial for the child and for public safety. Research limitations/implications Based on current evidence and theory, the authors argue that minimum age legislation that protects children from contact with the juvenile justice system and treats them as children in need of services and support, rather than as delinquents or criminals, is an important policy goal for California and for other national and international jurisdictions lacking a minimum age law. Originality/value California has no law specifying a minimum age for juvenile justice jurisdiction, meaning that young children of any age can be processed in the juvenile justice system. This policy brief provides a rationale for a minimum age law in California and other states and jurisdictions without one.

  20. MEASURING TINY MASS ACCRETION RATES ONTO YOUNG BROWN DWARFS

    International Nuclear Information System (INIS)

    Herczeg, Gregory J.; Cruz, Kelle L.; Hillenbrand, Lynne A.

    2009-01-01

    We present low-resolution Keck I/LRIS spectra spanning from 3200 to 9000 A of nine young brown dwarfs and three low-mass stars in the TW Hya Association and in Upper Sco. The optical spectral types of the brown dwarfs range from M5.5 to M8.75, though two have near-IR spectral types of early L dwarfs. We report new accretion rates derived from excess Balmer continuum emission for the low-mass stars TW Hya and Hen 3-600A and the brown dwarfs 2MASS J12073347-3932540, UScoCTIO 128, SSSPM J1102-3431, USco J160606.29-233513.3, DENIS-P J160603.9-205644, and Oph J162225-240515B, and upper limits on accretion for the low-mass star Hen 3-600B and the brown dwarfs UScoCTIO 112, Oph J162225-240515A, and USco J160723.82-221102.0. For the six brown dwarfs in our sample that are faintest at short wavelengths, the accretion luminosity or upper limit is measurable only when the image is binned over large wavelength intervals. This method extends our sensitivity to accretion rate down to ∼10 -13 M sun yr -1 for brown dwarfs. Since the ability to measure an accretion rate from excess Balmer continuum emission depends on the contrast between excess continuum emission and the underlying photosphere, for objects with earlier spectral types the upper limit on accretion rate is much higher. Absolute uncertainties in our accretion rate measurements of ∼3-5 include uncertainty in accretion models, brown dwarf masses, and distance. The accretion rate of 2 x 10 -12 M sun yr -1 onto 2MASS J12073347-3932540 is within 15% of two previous measurements, despite large changes in the Hα flux.

  1. The Juvenile Transition: A Developmental Switch Point in Human Life History

    Science.gov (United States)

    Del Giudice, Marco; Angeleri, Romina; Manera, Valeria

    2009-01-01

    This paper presents a new perspective on the transition from early to middle childhood (i.e., human juvenility), investigated in an integrative evolutionary framework. Juvenility is a crucial life history stage, when social learning and interaction with peers become central developmental functions; here it is argued that the "juvenile transition"…

  2. A Panchromatic View of Brown Dwarf Aurorae

    Energy Technology Data Exchange (ETDEWEB)

    Pineda, J. Sebastian [University of Colorado Boulder, Laboratory for Atmospheric and Space Physics, 3665 Discovery Drive, Boulder CO, 80303 (United States); Hallinan, Gregg; Kao, Melodie M. [California Institute of Technology, Department of Astronomy, 1200 E. California Avenue, Pasadena CA, 91125 (United States)

    2017-09-01

    Stellar coronal activity has been shown to persist into the low-mass star regime, down to late M-dwarf spectral types. However, there is now an accumulation of evidence suggesting that at the end of the main sequence, there is a transition in the nature of the magnetic activity from chromospheric and coronal to planet-like and auroral, from local impulsive heating via flares and MHD wave dissipation to energy dissipation from strong large-scale magnetospheric current systems. We examine this transition and the prevalence of auroral activity in brown dwarfs through a compilation of multiwavelength surveys of magnetic activity, including radio, X-ray, and optical. We compile the results of those surveys and place their conclusions in the context of auroral emission as a consequence of large-scale magnetospheric current systems that accelerate energetic electron beams and drive the particles to impact the cool atmospheric gas. We explore the different manifestations of auroral phenomena, like H α , in brown dwarf atmospheres and define their distinguishing characteristics. We conclude that large-amplitude photometric variability in the near-infrared is most likely a consequence of clouds in brown dwarf atmospheres, but that auroral activity may be responsible for long-lived stable surface features. We report a connection between auroral H α emission and quiescent radio emission in electron cyclotron maser instability pulsing brown dwarfs, suggesting a potential underlying physical connection between quiescent and auroral emissions. We also discuss the electrodynamic engines powering brown dwarf aurorae and the possible role of satellites around these systems both to power the aurorae and seed the magnetosphere with plasma.

  3. Sexual dimorphism and plumage characteristics of juvenile Cape ...

    African Journals Online (AJOL)

    Juveniles, or birds in their first year, were genetically sexed. Standardised photographs were taken of plucked juvenile breast feathers and analysed using Adobe Photoshop. Pixel counts were taken to analyse the streak coverage of a single feather. A scale from 0 to 3 was used to score streak intensity of the entire breast.

  4. Pattern of juvenile periodontitis in Lagos University Teaching ...

    African Journals Online (AJOL)

    Objective: The aim of the survey was to study the pattern of juvenile periodontitis patients that presented at the Lagos University Teaching Hospital Dental Centre from November 1999 to March 2004. Methods: Through review of case files of patients, twenty six juvenile periodontitis patients, within the age range of 18 and 30 ...

  5. Reduction of Exudates (Browning) in Sugarcane Micro Propagation ...

    African Journals Online (AJOL)

    ... of this variety, ascorbic acid and citric acid was added as constituent of the media using MS and stock at different concentrations. The browning was reduced drastically at the addition of 0.1g/litre ascorbic acid and 0.15g/litre citric acid. Keywords: reduction, exudates browning, micro propagation, sugarcane. Nig J. Biotech.

  6. Giant Bilateral Juvenile Fibroadenoma of the Breast in Prepubescent Girl.

    Science.gov (United States)

    Khan, Salma; Khan, Momna; Rafique, Sadia

    2015-10-01

    Juvenile fibroadenoma accounts for 4% of the total fibroadenomas. Giant juvenile fibroadenoma is found in only 0.5% of all fibroadenomas. The authors report a 10-year girl presenting with progressive enlargement of both breasts for one year. Based on clinical findings and Fine Needle Aspiration Cytology (FNAC), a diagnosis of bilateral giant juvenile fibroadenomas of breast was made. She underwent bilateral lumpectomy with breast conservation and made uneventful postoperative recovery.

  7. Reassessing the Anatomic Origin of the Juvenile Nasopharyngeal Angiofibroma.

    Science.gov (United States)

    McKnight, Colin D; Parmar, Hemant A; Watcharotone, Kuanwong; Mukherji, Suresh K

    A modern imaging review is necessary to further define the anatomic origin of the juvenile nasopharyngeal angiofibroma. After institutional review board approval, a search from January 1998 to January 2013 yielded 33 male patients (aged 10-23 years) with pathologically proven juvenile nasopharyngeal angiofibroma lesions, as well as pretreatment computed tomography/magnetic resonance imaging. Juvenile nasopharyngeal angiofibroma involvement was assessed in the following regions: sphenopalatine foramen, pterygopalatine fossa, vidian canal, nasopharynx, nasal cavity, sphenoid sinus, choana, pterygomaxillary fissure/masticator space, orbit, and sphenoid bone. The choana and nasopharynx were involved in all 33 patients. In contrast, only 22 lesions involved the pterygopalatine fossa, 24 lesions involved the sphenopalatine foramen, and 28 lesions involved the vidian canal. Our results suggest that the juvenile nasopharyngeal angiofibroma origin is in the region of the choana and nasopharynx rather than the sphenopalatine foramen or pterygopalatine fossa.

  8. Crocodylus acutus (American Crocodile). Long distance juvenile movement

    Science.gov (United States)

    Crespo, Rafael; Beauchamp, Jeffrey S.; Mazzotti, Frank; Cherkiss, Michael S.

    2015-01-01

    Crocodylus acutus (American Crocodile) is the most widely distributed New World crocodilian species with its range extending from Peru in the south to the southern tip of peninsular Florida in the north. Crocodylus acutus occupies primarily coastal brackish water habitat, however it also occurs in freshwater to hypersaline habitats (Thorbjarnarson 2010. In Crocodiles. Status Survey and Conservation Action Plan. [Third Edition], American Crocodile Crocodylus acutus, pp. 46–53 S.C. Manolis and C. Stevenson. Crocodile Specialist Group, Darwin). There is limited literature on long distance movements of juvenile crocodilians worldwide and no literature on juvenile crocodiles in Florida. However, adult C. acutus in Florida have been documented to make seasonal movements of 5–15 km from preferred foraging habitat to nesting beaches (Mazzotti 1983. The Ecology of Crocodylus acutus in Florida. PhD Dissertation. The Pennsylvania State University, University Park, Pennsylvania. 161pp), and one adult was documented making a 35 km trip from her nest site to preferred foraging habitat (Cherkiss et. al. 2006. Herpetol. Rev. 38:72–73). Rodda (1984. Herpetologica 40:444–451) reported on juvenile C. acutus movement in Gatun Lake, Panama, and found that juveniles stayed within 1 km of their nest site for the first month. Movements of juvenile Crocodylus porosus (Saltwater Crocodile) in a river system in Northern Australia showed a maximum movement of 38.9 km from a known nest site, with the majority of the crocodiles staying within 15.6 km downstream to 6.8 km upstream (Webb and Messel 1978. Aust. Wildlife Res. 5:263–283). Juvenile movement of Crocodylus niloticus (Nile Crocodile) in Lake Ngezi, Zimbabwe showed crocodiles restricted their movements from 1.0 km up to 4.5 km through the wet and dry seasons (Hutton 1989. Am. Zool. 29:1033–1049). Long distance movements of alligators were recorded for sizes ranging from 28 cm to 361 cm in a coastal refuge in Louisiana, where

  9. Musculoskeletal MRI findings of juvenile localized scleroderma

    Energy Technology Data Exchange (ETDEWEB)

    Eutsler, Eric P. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Wilmington, DE (United States); Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO (United States); Horton, Daniel B. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Division of Rheumatology, Department of Pediatrics, Wilmington, DE (United States); Rutgers Robert Wood Johnson Medical School, Department of Pediatrics, New Brunswick, NJ (United States); Epelman, Monica [Nemours Children' s Health System/Nemours Children' s Hospital, Department of Medical Imaging, Orlando, FL (United States); Finkel, Terri [Nemours Children' s Health System/Nemours Children' s Hospital, Department of Pediatrics, Orlando, FL (United States); Averill, Lauren W. [Nemours Children' s Health System/Alfred I. duPont Hospital for Children, Wilmington, DE (United States)

    2017-04-15

    Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol. (orig.)

  10. Musculoskeletal MRI findings of juvenile localized scleroderma

    International Nuclear Information System (INIS)

    Eutsler, Eric P.; Horton, Daniel B.; Epelman, Monica; Finkel, Terri; Averill, Lauren W.

    2017-01-01

    Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol. (orig.)

  11. Musculoskeletal MRI findings of juvenile localized scleroderma.

    Science.gov (United States)

    Eutsler, Eric P; Horton, Daniel B; Epelman, Monica; Finkel, Terri; Averill, Lauren W

    2017-04-01

    Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children. We aimed to document the spectrum of musculoskeletal magnetic resonance imaging (MRI) findings of both superficial and deep juvenile localized scleroderma involvement in children and to evaluate the utility of various MRI sequences for detecting those findings. Two radiologists retrospectively evaluated 20 MRI studies of the extremities in 14 children with juvenile localized scleroderma. Each imaging sequence was also given a subjective score of 0 (not useful), 1 (somewhat useful) or 2 (most useful for detecting the findings). Deep tissue involvement was detected in 65% of the imaged extremities. Fascial thickening and enhancement were seen in 50% of imaged extremities. Axial T1, axial T1 fat-suppressed (FS) contrast-enhanced and axial fluid-sensitive sequences were rated most useful. Fascial thickening and enhancement were the most commonly encountered deep tissue findings in extremity MRIs of children with juvenile localized scleroderma. Because abnormalities of the skin, subcutaneous tissues and fascia tend to run longitudinally in an affected limb, axial T1, axial fluid-sensitive and axial T1-FS contrast-enhanced sequences should be included in the imaging protocol.

  12. Direct Evidence of Brown Adipocytes in Different Fat Depots in Children

    Science.gov (United States)

    Rockstroh, Denise; Landgraf, Kathrin; Wagner, Isabel Viola; Gesing, Julia; Tauscher, Roy; Lakowa, Nicole; Kiess, Wieland; Bühligen, Ulf; Wojan, Magdalena; Till, Holger; Blüher, Matthias; Körner, Antje

    2015-01-01

    Recent studies suggested the persistence of brown adipocytes in adult humans, as opposed to being exclusively present in infancy. In this study, we investigated the presence of brown-like adipocytes in adipose tissue (AT) samples of children and adolescents aged 0 to 18 years and evaluated the association with age, location, and obesity. For this, we analysed AT samples from 131 children and 23 adults by histological, immunohistochemical and expression analyses. We detected brown-like and UCP1 positive adipocytes in 10.3% of 87 lean children (aged 0.3 to 10.7 years) and in one overweight infant, whereas we did not find brown adipocytes in obese children or adults. In our samples, the brown-like adipocytes were interspersed within white AT of perirenal, visceral and also subcutaneous depots. Samples with brown-like adipocytes showed an increased expression of UCP1 (>200fold), PRDM16 (2.8fold), PGC1α and CIDEA while other brown/beige selective markers, such as PAT2, P2RX5, ZIC1, LHX8, TMEM26, HOXC9 and TBX1 were not significantly different between UCP1 positive and negative samples. We identified a positive correlation between UCP1 and PRDM16 within UCP1 positive samples, but not with any other brown/beige marker. In addition, we observed significantly increased PRDM16 and PAT2 expression in subcutaneous and visceral AT samples with high UCP1 expression in adults. Our data indicate that brown-like adipocytes are present well beyond infancy in subcutaneous depots of non-obese children. The presence was not restricted to typical perirenal locations, but they were also interspersed within WAT of visceral and subcutaneous depots. PMID:25706927

  13. Regulation of glycolysis in brown adipocytes by HIF-1α

    DEFF Research Database (Denmark)

    Basse, Astrid L; Isidor, Marie S; Winther, Sally

    2017-01-01

    Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold-exposed mice. Accordingly, these genes were also...... with glucose as the only exogenously added fuel. These data suggest that HIF-1α-dependent regulation of glycolysis is necessary for maximum glucose metabolism in brown adipocytes....

  14. Effect of TBT on Ruditapes decussatus juveniles.

    Science.gov (United States)

    Coelho, M R; Langston, W J; Bebianno, M J

    2006-06-01

    The effects of sublethal concentrations of tributyltin (TBT) on growth of juvenile clams Ruditapes decussatus were determined during exposure to TBT concentrations of 50, 100 and 250 ng l(-1) (as Sn) for a period up to two years. Length and weight of clams increased continuously in all treatments throughout the experimental period, and, overall, rates were not significantly influenced by TBT exposure, although final length and weight were inversely related to increasing TBT concentration. Juvenile R. decussatus therefore appear to be less sensitive to TBT than larval stages. Some juveniles exposed to TBT developed abnormal shell growth, laterally, changing the typical flattened shape of clams into a more "rounded" form. This characteristic was more visible in the anterior margins of valves than posteriorly, and mainly observed in clams exposed to TBT at 50 ng l(-1) (as Sn).

  15. New Brown Dwarf Discs in Upper Scorpius Observed with WISE

    Science.gov (United States)

    Dawson, P.; Scholz, A.; Ray, T. P.; Natta, A.; Marsh, K. A.; Padgett, D.; Ressler, M. E.

    2013-01-01

    We present a census of the disc population for UKIDSS selected brown dwarfs in the 5-10 Myr old Upper Scorpius OB association. For 116 objects originally identified in UKIDSS, the majority of them not studied in previous publications, we obtain photometry from the Wide-Field Infrared Survey Explorer data base. The resulting colour magnitude and colour colour plots clearly show two separate populations of objects, interpreted as brown dwarfs with discs (class II) and without discs (class III). We identify 27 class II brown dwarfs, 14 of them not previously known. This disc fraction (27 out of 116, or 23%) among brown dwarfs was found to be similar to results for K/M stars in Upper Scorpius, suggesting that the lifetimes of discs are independent of the mass of the central object for low-mass stars and brown dwarfs. 5 out of 27 discs (19 per cent) lack excess at 3.4 and 4.6 microns and are potential transition discs (i.e. are in transition from class II to class III). The transition disc fraction is comparable to low-mass stars.We estimate that the time-scale for a typical transition from class II to class III is less than 0.4 Myr for brown dwarfs. These results suggest that the evolution of brown dwarf discs mirrors the behaviour of discs around low-mass stars, with disc lifetimes of the order of 5 10 Myr and a disc clearing time-scale significantly shorter than 1 Myr.

  16. Cellular origins of cold-induced brown adipocytes in adult mice.

    Science.gov (United States)

    Lee, Yun-Hee; Petkova, Anelia P; Konkar, Anish A; Granneman, James G

    2015-01-01

    This work investigated how cold stress induces the appearance of brown adipocytes (BAs) in brown and white adipose tissues (WATs) of adult mice. In interscapular brown adipose tissue (iBAT), cold exposure increased proliferation of endothelial cells and interstitial cells expressing platelet-derived growth factor receptor, α polypeptide (PDGFRα) by 3- to 4-fold. Surprisingly, brown adipogenesis and angiogenesis were largely restricted to the dorsal edge of iBAT. Although cold stress did not increase proliferation in inguinal white adipose tissue (ingWAT), the percentage of BAs, defined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of total adipocytes. To trace the origins of cold-induced BAs, we genetically tagged PDGFRα(+) cells and adipocytes prior to cold exposure, using Pdgfra-Cre recombinase estrogen receptor T2 fusion protein (CreER(T2)) and adiponectin-CreER(T2), respectively. In iBAT, cold stress triggered the proliferation and differentiation of PDGFRα(+) cells into BAs. In contrast, all newly observed BAs in ingWAT (5207 out of 5207) were derived from unilocular adipocytes tagged by adiponectin-CreER(T2)-mediated recombination. Surgical denervation of iBAT reduced cold-induced brown adipogenesis by >85%, whereas infusion of norepinephrine (NE) mimicked the effects of cold in warm-adapted mice. NE-induced de novo brown adipogenesis in iBAT was eliminated in mice lacking β1-adrenergic receptors. These observations identify a novel tissue niche for brown adipogenesis in iBAT and further define depot-specific mechanisms of BA recruitment. © FASEB.

  17. The "brown" environmental agenda and the constitutional duties of ...

    African Journals Online (AJOL)

    This note explores the interrelationship between ecologically sustainable development (the green environmental agenda) and pro-poor urban development and environmental health (the brown environmental agenda) in relation to local government in South Africa. The meaning and relevance of the brown agenda versus ...

  18. Change in Family Structure and Rates of Violent Juvenile Delinquency

    OpenAIRE

    Fry, Jeannie A

    2010-01-01

    This paper addresses the question: Have the changes in family structure in the U.S. become a catalyst for juvenile delinquency? For this research, I use existing statistics for my three independent variables: divorce rates, rate of working mothers with children under age 18, percent female-headed households. My dependent variable, juvenile violent crime rates, is measured using data from the Office of Juvenile Justice and Delinquency Prevention. My control variables consist of the followin...

  19. Setting a minimum age for juvenile justice jurisdiction in California

    Science.gov (United States)

    Barnert, Elizabeth S.; Abrams, Laura S.; Maxson, Cheryl; Gase, Lauren; Soung, Patricia; Carroll, Paul; Bath, Eraka

    2018-01-01

    Purpose Despite the existence of minimum age laws for juvenile justice jurisdiction in 18 US states, California has no explicit law that protects children (i.e. youth less than 12 years old) from being processed in the juvenile justice system. In the absence of a minimum age law, California lags behind other states and international practice and standards. The paper aims to discuss these issues. Design/methodology/approach In this policy brief, academics across the University of California campuses examine current evidence, theory, and policy related to the minimum age of juvenile justice jurisdiction. Findings Existing evidence suggests that children lack the cognitive maturity to comprehend or benefit from formal juvenile justice processing, and diverting children from the system altogether is likely to be more beneficial for the child and for public safety. Research limitations/implications Based on current evidence and theory, the authors argue that minimum age legislation that protects children from contact with the juvenile justice system and treats them as children in need of services and support, rather than as delinquents or criminals, is an important policy goal for California and for other national and international jurisdictions lacking a minimum age law. Originality/value California has no law specifying a minimum age for juvenile justice jurisdiction, meaning that young children of any age can be processed in the juvenile justice system. This policy brief provides a rationale for a minimum age law in California and other states and jurisdictions without one. Paper type Conceptual paper PMID:28299968

  20. Black, White, and Brown: The Transformation of Public Education in America

    Science.gov (United States)

    Willie, Charles Vert; Willie, Sarah Susannah

    2005-01-01

    This article reflects upon changes in U.S. education since the U.S. Supreme Court's 1954 decision in Brown v. the Board of Education of Topeka, Kansas. The authors reject both the naively hopeful and the bitterly cynical interpretations of the efficacy of Brown in favor of a more moderate assessment: Brown has had many positive effects, they…

  1. Marine nurseries and effective juvenile habitats: concepts and applications.

    NARCIS (Netherlands)

    Dahlgren, C.P.; Kellison, G.T.; Adams, A.J.; Gillanders, B.M.; Kendall, M.S.; Layman, C.A.; Ley, J.A.; Nagelkerken, I.; Serafy, J.E.

    2006-01-01

    Much recent attention has been focused on juvenile fish and invertebrate habitat use, particularly defining and identifying marine nurseries. The most significant advancement in this area has been the development of a standardized framework for assessing the relative importance of juvenile habitats

  2. 75 FR 70293 - Meeting of the Federal Advisory Committee on Juvenile Justice

    Science.gov (United States)

    2010-11-17

    ... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OJJDP) Docket No. 1532] Meeting of the Federal Advisory Committee on Juvenile Justice AGENCY: Office of Juvenile Justice and Delinquency Prevention, Office of Justice Programs, Justice. ACTION: Notice of Meeting. SUMMARY: The Office of Juvenile...

  3. Juvenile delinquency in Russia: Ccriminal justice, trends, key issues

    Directory of Open Access Journals (Sweden)

    Kovačević Milica

    2015-01-01

    Full Text Available In the literature, as well as in international statistical surveys, we can rarely find more detailed information on juvenile delinquency in the Russian Federation, as well as on the criminal reaction towards juvenile offenders. Due to the turbulent conditions and great social turmoil which took place in the last few decades in this country, there should be a greater interest in the problem of juvenile delinquency. For Serbia, the experience of the Russian Federation could be especially important if one bears in mind that our country is still going through a transition, population stratification and through economic crisis, and also that Serbia and the Russian Federation share some cultural and religious similarities. Therefore, the aim of this paper is to present, in the summary way, the basic features of juvenile delinquency and the criminal justice system, and thereby build a basis for future research and comparison.

  4. What happened to the Kuo-Brown interaction?

    International Nuclear Information System (INIS)

    Osnes, E.

    1987-01-01

    Twenty years of efforts to calculate the shell-model effective interaction, starting from the free nucleon-nucleon (NN) interaction and using many-body perturbation theory, are briefly reviewed. A description is given of the pioneering work of Kuo and Brown, in which the effective interaction was approximated by the Bethe-Brueckner-Goldstone G-matrix and the lowest order core-polarization correction. Subsequent developments which cast doubt upon the simple Kuo-Brown approximation are reviewed. Some of these problems have been shown to arise from inadequate treatment of various higher order contributions, whereas other problems are related to the strong tensor component of the NN interaction used. In fact, modern meson-exchange potentials have much weaker tensor forces and give rise to effective interactions which are similar to the original Kuo-Brown interaction. Applications of these new effective forces to shell-model calculations in the sd-shell are discussed

  5. Brown dwarfs forming in discs: Where to look for them?

    Directory of Open Access Journals (Sweden)

    Stamatellos D.

    2011-07-01

    Full Text Available A large fraction of the observed brown dwarfs may form by gravitational fragmentation of unstable discs. This model reproduces the brown dwarf desert, and provides an explanation for the existence of planetary-mass objects and for the binary properties of low-mass objects. We have performed an ensemble of radiative hydrodynamic simulations and determined the statistical properties of the low-mass objects produced by gravitational fragmentation of discs. We suggest that there is a population of brown dwarfs loosely bound on wide orbits (100–5000 AU around Sun-like stars that surveys of brown dwarf companions should target. Our simulations also indicate that planetary-mass companions to Sun-like stars are unlikely to form by disc fragmentation.

  6. Startup operation of Browns Ferry's 1152-MW nuclear units

    International Nuclear Information System (INIS)

    Calhoun, J.R.; Green, H.J.; Beers, R.B.

    1975-01-01

    An overview is presented of startup operation for the Browns Ferry-1 reactor, and comparisons are made with the startup of Browns Ferry-2. Included are comments on the selection of the BWR type steam supply system, reactor fueling, problems encountered, and plant availability

  7. Phytase activity in brown rice during steeping and sprouting

    NARCIS (Netherlands)

    Ou, K.; Cheng, Y.; Xing, Y.; Lin, L.; Nout, M.J.R.; Liang, J.

    2011-01-01

    Phytase in brown rice will be activated and accumulated during seed germination. Changes of phytase activity in brown rice during two stages of germination (steeping and sprouting) affected by process conditions were studied. It was shown that steeping led to significant decrease of phytase activity

  8. Radioangiography in diagnosis of juvenile angiofibroma

    International Nuclear Information System (INIS)

    Kalantarov, K.D.; Anyutin, R.G.; Ashikhmina, I.G.

    1979-01-01

    To study the blood supply of juvenile angiofibroma of the nasopharynx 10 patients were examined (2 of them were examined twice). Four patients with the deseases of the nose and the nasopharynx of a nonvascular nature were in the control group. The authors used sup(99m)Tc for radioangiography. The investigations were made on the gamma-chamber ''Nuclear-Chicago'' connected to the computer ''Cina-200''. Ten patients with juvenile angiofibroma of the nasopharynx showed rapid accumulation of the radioactive substance at the site of the tumour exceeding its concentration in the carotic arteries by 4-10 times. In unilateral localization of angiofibroma, its blood supply was provided mainly through the external carotic artery at the affection site or evenly through the both external carotic arteries. The data on dynamic distribution of the radioactive substance, scintiphotograms and clinical observations allow a distinct differentiation between juvenile angiofibroma of the nasopharynx the adenoid tissue or any other tumour to determine the angiofibroma size as well as to follow the results of surgical and radiation treatment

  9. Being Black and Brown in the 21st Century

    Directory of Open Access Journals (Sweden)

    Pierre W. Orelus

    2012-11-01

    Full Text Available Depending on one’s level of understanding and awareness about the plight of Black and Brown people, one might argue that they are better off today than they were 50 years ago or so, especially when one remembers the Jim Crow era during which Black and Brown people were ruthlessly brutalized, particularly by White supremacist groups such as the Klu Klux Kan. However, if one critically analyzed the achievement gap between students of color and their White counterparts, the decline in incomes, and other forms of educational and socioeconomic inequality that Black and Brown people, particularly poor students of color, have been experiencing for the last several decades or so, one would realize that substantially nothing has changed for them. In light of this view, this article explores the educational and socioeconomic conditions of People of Color, including those of linguistically and culturally diverse students. Specifically, it examines the ways and the degree to which lack of resources combined with institutional racism and the legacy of slavery continue to limit the life chances of Black and Brown people in the 21st century. The author ends this article making recommendations to counter inequality in schools and society at large that Black and Brown people have been facing.

  10. Social skills training for juvenile delinquents : post-treatment changes

    NARCIS (Netherlands)

    van der Stouwe, Trudy; Asscher, Jessica J.; Hoeve, Machteld; van der Laan, Peter H.; Stams, Geert Jan J M

    2016-01-01

    Objectives: To examine the post-treatment effectiveness of an outpatient, individual social skills training for juvenile delinquents in the Netherlands and to conduct moderator tests for age, gender, ethnicity, and risk of reoffending. Methods: The sample consisted of juveniles who received Tools4U,

  11. Social Skills Training for Juvenile Delinquents: Post-Treatment Changes

    NARCIS (Netherlands)

    van der Stouwe, Trudy; Asscher, J.J.; Stams, G.J.J.M.; Hoeve, M.; van der Laan, Peter H.

    2016-01-01

    Objectives: To examine the post-treatment effectiveness of an outpatient, individual social skills training for juvenile delinquents in the Netherlands and to conduct moderator tests for age, gender, ethnicity, and risk of reoffending. Methods: The sample consisted of juveniles who received Tools4U,

  12. Social skills training for juvenile delinquents : Post-treatment changes

    NARCIS (Netherlands)

    van der Stouwe, T.; Asscher, J.J.; Hoeve, M.; van der Laan, P.H.; Stams, G.J.J.M.

    2016-01-01

    Objectives To examine the post-treatment effectiveness of an outpatient, individual social skills training for juvenile delinquents in the Netherlands and to conduct moderator tests for age, gender, ethnicity, and risk of reoffending. Methods The sample consisted of juveniles who received Tools4U, a

  13. Linkage and association mapping reveals the genetic basis of brown fibre (Gossypium hirsutum).

    Science.gov (United States)

    Wen, Tianwang; Wu, Mi; Shen, Chao; Gao, Bin; Zhu, De; Zhang, Xianlong; You, Chunyuan; Lin, Zhongxu

    2018-02-24

    Brown fibre cotton is an environmental-friendly resource that plays a key role in the textile industry. However, the fibre quality and yield of natural brown cotton are poor, and fundamental research on brown cotton is relatively scarce. To understand the genetic basis of brown fibre cotton, we constructed linkage and association populations to systematically examine brown fibre accessions. We fine-mapped the brown fibre region, Lc 1 , and dissected it into 2 loci, qBF-A07-1 and qBF-A07-2. The qBF-A07-1 locus mediates the initiation of brown fibre production, whereas the shade of the brown fibre is affected by the interaction between qBF-A07-1 and qBF-A07-2. Gh_A07G2341 and Gh_A07G0100 were identified as candidate genes for qBF-A07-1 and qBF-A07-2, respectively. Haploid analysis of the signals significantly associated with these two loci showed that most tetraploid modern brown cotton accessions exhibit the introgression signature of Gossypium barbadense. We identified 10 quantitative trait loci (QTLs) for fibre yield and 19 QTLs for fibre quality through a genome-wide association study (GWAS) and found that qBF-A07-2 negatively affects fibre yield and quality through an epistatic interaction with qBF-A07-1. This study sheds light on the genetics of fibre colour and lint-related traits in brown fibre cotton, which will guide the elite cultivars breeding of brown fibre cotton. © 2018 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  14. Effective production of fermentable sugars from brown macroalgae biomass.

    Science.gov (United States)

    Wang, Damao; Kim, Do Hyoung; Kim, Kyoung Heon

    2016-11-01

    Brown macroalgae are renewable and sustainable biomass resources for the production of biofuels and chemicals, owing to their high levels of carbohydrates and low levels of lignin. To increase the biological usage of brown macroalgae, it is necessary to depolymerize the polysaccharides that generate macroalgal monomeric sugars or sugar derivatives and to convert them into fermentable sugars for the production of biofuels and chemicals. In this review, we discuss the chemical and enzymatic saccharification of the major carbohydrates found in brown macroalgae and the use of the resulting constituents in the production of biofuels and chemicals, as well as high-value health-benefiting functional oligosaccharides and sugars. We also discuss recently reported experimental results, novel enzymes, and technological breakthroughs that are related to polysaccharide depolymerization, fermentable sugar production, and the biological conversion of non-favorable sugars for fermentation using industrial microorganisms. This review provides a comprehensive perspective of the efficient utilization of brown macroalgae as renewable resources for the production of biofuels and chemicals.

  15. A case of multiple brown tumors with primary hyperparathyroidism.

    Science.gov (United States)

    Mori, Hiroko; Okada, Yosuke; Arao, Tadashi; Shimaziri, Shohei; Tanaka, Yoshiya

    2013-01-01

    We report a case of large multiple brown tumors in a patient with primary hyperparathyroidism. A 52-year-old woman suffered from pain in the ribs and developed left facial swelling and deformity. CT showed a large destructive osteolytic lesion in the left maxillary sinus. Biopsy showed a lesion with newly formed bone tissue, diffuse giant cells and deposits of hemosiderin. In addition, similar lesions were also observed in the ribs, iliac bones and pelvis. The laboratory data showed hypercalcemia and hyperparathyroidism. Cervical echo and (201)Tl-(99m)TcO(4-) scintigraphy demonstrated a right lower swollen parathyroid adenoma. The diagnosis was multiple brown tumors with primary hyperparathyroidism and parathyroidectomy was performed. Follow-up CT showed marked decreases in the size of osteolytic lesions with calcification in the brown tumors compared to pre-treatment findings. These changes were associated with marked improvement in pain and facial deformity. We described a rare case of multiple brown tumors appeared in the maxilla associated with primary hyperparathyroidism.

  16. Tracking from the tropics reveals behaviour of juvenile songbirds on their first spring migration.

    Directory of Open Access Journals (Sweden)

    Emily A McKinnon

    Full Text Available Juvenile songbirds on spring migration travel from tropical wintering sites to temperate breeding destinations thousands of kilometres away with no prior experience to guide them. We provide a first glimpse at the migration timing, routes, and stopover behaviour of juvenile wood thrushes (Hylocichla mustelina on their inaugural spring migration by using miniaturized archival geolocators to track them from Central America to the U.S. and Canada. We found significant differences between the timing of juvenile migration and that of more experienced adults: juveniles not only departed later from tropical wintering sites relative to adults, they also became progressively later as they moved northward. The increasing delay was driven by more frequent short stops by juveniles along their migration route, particularly in the U.S. as they got closer to breeding sites. Surprisingly, juveniles were just as likely as adults to cross the Gulf of Mexico, an open-water crossing of 800-1000 km, and migration route at the Gulf was not significantly different for juveniles relative to adults. To determine if the later departure of juveniles was related to poor body condition in winter relative to adults, we examined percent lean body mass, fat scores, and pectoral muscle scores of juvenile versus adult birds at a wintering site in Belize. We found no age-related differences in body condition. Later migration timing of juveniles relative to adults could be an adaptive strategy (as opposed to condition-dependent to avoid the high costs of fast migration and competition for breeding territories with experienced and larger adults. We did find significant differences in wing size between adults and juveniles, which could contribute to lower flight efficiency of juveniles and thus slower overall migration speed. We provide the first step toward understanding the "black box" of juvenile songbird migration by documenting their migration timing and en route performance.

  17. Introgressive hybridization: brown bears as vectors for polar bear alleles.

    Science.gov (United States)

    Hailer, Frank

    2015-03-01

    The dynamics and consequences of introgression can inform about numerous evolutionary processes. Biologists have therefore long been interested in hybridization. One challenge, however, lies in the identification of nonadmixed genotypes that can serve as a baseline for accurate quantification of admixture. In this issue of Molecular Ecology, Cahill et al. (2015) analyse a genomic data set of 28 polar bears, eight brown bears and one American black bear. Polar bear alleles are found to be introgressed into brown bears not only near a previously identified admixture zone on the Alaskan Admiralty, Baranof and Chichagof (ABC) Islands, but also far into the North American mainland. Elegantly contrasting admixture levels at autosomal and X chromosomal markers, Cahill and colleagues infer that male-biased dispersal has spread these introgressed alleles away from the Late Pleistocene contact zone. Compared to a previous study on the ABC Island population in which an Alaskan brown bear served as a putatively admixture-free reference, Cahill et al. (2015) utilize a newly sequenced Swedish brown bear as admixture baseline. This approach reveals that brown bears have been impacted by introgression from polar bears to a larger extent (up to 8.8% of their genome), than previously known, including the bear that had previously served as admixture baseline. No evidence for introgression of brown bear into polar bear is found, which the authors argue could be a consequence of selection. Besides adding new exciting pieces to the puzzle of polar/brown bear evolutionary history, the study by Cahill and colleagues highlights that wildlife genomics is moving from analysing single genomes towards a landscape genomics approach. © 2015 John Wiley & Sons Ltd.

  18. Martial arts participation and externalizing behavior in juveniles : A meta-analytic review

    NARCIS (Netherlands)

    Gubbels, J.; van der Stouwe, T.; Spruit, A.; Stams, G.J.J.M.

    2016-01-01

    Martial arts are very popular among juveniles all over the world, but the relation between martial arts and externalizing behavior in juveniles remains unclear. The current multilevel meta-analysis of 12 studies, including 94 effect sizes and N = 5949 juveniles, was conducted to examine the relation

  19. The Mechanism of White and Brown Adipocyte Differentiation

    Directory of Open Access Journals (Sweden)

    Hironori Nakagami

    2013-04-01

    Full Text Available Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue. In human body, exist two types of adipose tissue, the white and the brown one, which are reported to play various roles in energy homeostasis. The major and most efficient storage of energy occurs in the form of triglycerides in white adipose tissue while brown adipose tissue actively participates in both basal and inducible energy consumption in the form of thermogenesis. Recent years have observed a rapid and greater interest towards developmental plasticity and therapeutic potential of stromal cells those isolated from adipose tissue. The adipocyte differentiation involves a couple of regulators in the white or brown adipogenesis. Peroxisome proliferators-activated receptor-γ actively participates in regulating carbohydrate and lipid metabolism, and also acts as main regulator of both white and brown adipogenesis. This review based on our recent research, seeks to highlight the adipocyte differentiation.

  20. CORRELATION BETWEEN FAMILY COMMUNICATION PATTERNS AND JUVENILE DELINQUENCY IN JUNIOR HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Zurriyatun Thoyibah

    2017-08-01

    Full Text Available Background: Adolescents who are in transition period have high risk behavior of juvenile delinquency. Communication between parents and adolescents effectively and openly could help adolescents to avoid delinquency behavior. Objective: This study aims to examine the relationship between family communication patterns and juvenile delinquency in Junior High School. Methods: This research employed a cross-sectional design with correlation description approach. There were 243 students selected using simple random sampling from the 7th and 8th grade students of Junior High School. A questionnaire of juvenile delinquency and family communication pattern were used in this study. Data were analyzed using Chi Square test. Result: The research showed that the majority juvenile delinquency category was low (65% and the majority of communication pattern was in functional category (73.3%. There was a significant relationship between family communication pattern and juvenile delinquency (p<0.05. Conclusion: Communication pattern within family have significant association with juvenile delinquency.

  1. 50 years of brown dwarfs from prediction to discovery to forefront of research

    CERN Document Server

    2014-01-01

    The years 2012/2013 mark the 50th anniversary of the theoretical prediction that Brown Dwarfs, i.e. degenerate objects which are just not massive enough to sustain stable hydrogen fusion, exist. Some 20 years after their discovery, how Brown Dwarfs form is still one of the main open questions in the theory of star formation. In this volume, the pioneers of Brown Dwarf research review the history of the theoretical prediction and the subsequent discovery of Brown Dwarfs. After an introduction, written by Viki Joergens, reviewing Shiv Kumar's theoretical prediction of the existence of brown dwarfs, Takenori Nakano reviews his and Hayashi's calculation of the Hydrogen Burning Minimum Mass. Both predictions happened in the early 1960s. Jill Tarter then writes on the introduction of the term 'Brown Dwarf', before Ben Oppenheimer, Rafael Rebolo and Gibor Basri describe their first discovery of Brown Dwarfs in the 1990s. Lastly, Michael Cushing and Isabelle Baraffe describe the development of the field to the curren...

  2. Widespread introgression of mountain hare genes into Fennoscandian brown hare populations.

    Directory of Open Access Journals (Sweden)

    Riikka Levänen

    Full Text Available In Fennoscandia, mountain hare (Lepus timidus and brown hare (Lepus europaeus hybridize and produce fertile offspring, resulting in gene flow across the species barrier. Analyses of maternally inherited mitochondrial DNA (mtDNA show that introgression occur frequently, but unavailability of appropriate nuclear DNA markers has made it difficult to evaluate the scale- and significance for the species. The extent of introgression has become important as the brown hare is continuously expanding its range northward, at the apparent expense of the mountain hare, raising concerns about possible competition. We report here, based on analysis of 6833 SNP markers, that the introgression is highly asymmetrical in the direction of gene flow from mountain hare to brown hare, and that the levels of nuclear gene introgression are independent of mtDNA introgression. While it is possible that brown hares obtain locally adapted alleles from the resident mountain hares, the low levels of mountain hare alleles among allopatric brown hares suggest that hybridization is driven by stochastic processes. Interspecific geneflow with the brown hare is unlikely to have major impacts on mountain hare in Fennoscandia, but direct competition may.

  3. Cardiac juvenile xanthogranuloma in an infant presenting with pericardial effusion.

    Science.gov (United States)

    Kobayashi, Daisuke; Delius, Ralph E; Debelenko, Larisa V; Aggarwal, Sanjeev

    2013-01-01

    Juvenile xanthogranuloma is a rare histiocytic disorder of childhood mainly affecting skin and rarely deep soft tissues and viscera. We report a 2-month-old infant who presented with respiratory distress secondary to a large pericardial effusion associated with an epicardial mass. Excisional biopsy was performed and the mass was diagnosed as juvenile xanthogranuloma. The child is well without evidence of disease 8 months following the excision. The corresponding literature on juvenile xanthogranuloma with cardiac manifestations is reviewed. © 2012 Wiley Periodicals, Inc.

  4. Approaches to diagnosis and detection of cassava brown streak ...

    African Journals Online (AJOL)

    Cassava brown streak disease (CBSD) has been a problem in the East African coastal cassava growing areas for more than 70 years. The disease is caused by successful infection with Cassava Brown Streak Virus (CBSV) (Family, Potyviridae: Genus, Ipomovirus). Diagnosis of CBSD has for long been primarily leaf ...

  5. Fermented Brown Rice Flour as Functional Food Ingredient.

    Science.gov (United States)

    Ilowefah, Muna; Chinma, Chiemela; Bakar, Jamilah; Ghazali, Hasanah M; Muhammad, Kharidah; Makeri, Mohammad

    2014-02-12

    As fermentation could reduce the negative effects of bran on final cereal products, the utilization of whole-cereal flour is recommended, such as brown rice flour as a functional food ingredient. Therefore, this study aimed to investigate the effect of fermented brown rice flour on white rice flour, white rice batter and its steamed bread qualities. Brown rice batter was fermented using commercial baker's yeast (Eagle brand) according to the optimum conditions for moderate acidity (pH 5.5) to obtain fermented brown rice flour (FBRF). The FBRF was added to white rice flour at 0%, 10%, 20%, 30%, 40% and 50% levels to prepare steamed rice bread. Based on the sensory evaluation test, steamed rice bread containing 40% FBRF had the highest overall acceptability score. Thus, pasting properties of the composite rice flour, rheological properties of its batter, volume and texture properties of its steamed bread were determined. The results showed that peak viscosity of the rice flour containing 40% FBRF was significantly increased, whereas its breakdown, final viscosity and setback significantly decreased. Viscous, elastic and complex moduli of the batter having 40% FBRF were also significantly reduced. However, volume, specific volume, chewiness, resilience and cohesiveness of its steamed bread were significantly increased, while hardness and springiness significantly reduced in comparison to the control. These results established the effectiveness of yeast fermentation in reducing the detrimental effects of bran on the sensory properties of steamed white rice bread and encourage the usage of brown rice flour to enhance the quality of rice products.

  6. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling

    Directory of Open Access Journals (Sweden)

    Rajan eSingh

    2014-10-01

    Full Text Available Obesity develops from perturbations of cellular bioenergetics, when energy uptake exceeds energy expenditure, and represents a major risk factor for the development of type 2 diabetes, dyslipidemia, cardiovascular disease, cancer, and other conditions. Brown adipose tissue (BAT has long been known to dissipate energy as heat and contribute to energy expenditure, but its presence and physiological role in adult human physiology has been questioned for years. Recent demonstrations of metabolically active brown fat depots in adult humans have revolutionized current therapeutic approaches for obesity-related diseases. The balance between white adipose tissue (WAT and BAT affects the systemic energy balance and is widely believed to be the key determinant in the development of obesity and related metabolic diseases. Members of the transforming growth factor-beta (TGF-β superfamily play an important role in regulating overall energy homeostasis by modulation of brown adipocyte characteristics. Inactivation of TGF-β/Smad3/myostatin (Mst signaling promotes browning of white adipocytes, increases mitochondrial biogenesis and protects mice from diet-induced obesity, suggesting the need for development of a novel class of TGF-β/Mst antagonists for the treatment of obesity and related metabolic diseases. We recently described an important role of follistatin (Fst, a soluble glycoprotein that is known to bind and antagonize Mst actions, during brown fat differentiation and the regulation of cellular metabolism. Here we highlight various investigations performed using different in vitro and in vivo models to support the contention that targeting TGF-β/Mst signaling enhances brown adipocyte functions and regulates energy balance, reducing insulin resistance and curbing the development of obesity and diabetes.

  7. SILICATE EVOLUTION IN BROWN DWARF DISKS

    International Nuclear Information System (INIS)

    Riaz, B.

    2009-01-01

    We present a compositional analysis of the 10 μm silicate spectra for brown dwarf disks in the Taurus and Upper Scorpius (UppSco) star-forming regions, using archival Spitzer/Infrared Spectrograph observations. A variety in the silicate features is observed, ranging from a narrow profile with a peak at 9.8 μm, to nearly flat, low-contrast features. For most objects, we find nearly equal fractions for the large-grain and crystalline mass fractions, indicating both processes to be active in these disks. The median crystalline mass fraction for the Taurus brown dwarfs is found to be 20%, a factor of ∼2 higher than the median reported for the higher mass stars in Taurus. The large-grain mass fractions are found to increase with an increasing strength in the X-ray emission, while the opposite trend is observed for the crystalline mass fractions. A small 5% of the Taurus brown dwarfs are still found to be dominated by pristine interstellar medium-like dust, with an amorphous submicron grain mass fraction of ∼87%. For 15% of the objects, we find a negligible large-grain mass fraction, but a >60% small amorphous silicate fraction. These may be the cases where substantial grain growth and dust sedimentation have occurred in the disks, resulting in a high fraction of amorphous submicron grains in the disk surface. Among the UppSco brown dwarfs, only usd161939 has a signal-to-noise ratio high enough to properly model its silicate spectrum. We find a 74% small amorphous grain and a ∼26% crystalline mass fraction for this object.

  8. Angiofibroma juvenil nasofaríngeo Juvenile nasopharyngeal angiofibroma

    Directory of Open Access Journals (Sweden)

    Juan Gualberto Lescaille Torres

    2012-06-01

    Full Text Available Se presenta el caso de un angiofibroma juvenil nasofaríngeo, en un paciente del consultorio médico No. 9, que pertenece al Policlínico Integral Docente "Carlos Manuel Portuondo" de Marianao. Se reconoce la importancia de realizar una historia clínica detallada, así como un minucioso examen físico, por el médico de familia y el otorrinolaringólogo del área de salud, que incluyó la rinoscopia posterior, para poder llegar al diagnóstico de esa patología, y realizar la extirpación precoz del angiofibroma, mediante el proceder quirúrgico. Se concluyó que el diagnóstico clínico se correspondió con el histopatológico, y que la conducta quirúrgica temprana es resolutiva en la afección.It is presented a case of juvenile nasopharyngeal angiofibroma in a patient with this pathology, from the clicial practice No. 9, in Comprehensive Teaching Polyclinic "Carlos Manuel Portuondo" in Marianao. It recognizes the importance of a thorough clinical history and careful physical examination by the family physician and the otolaryngologist in this health area, including a posterior rhinoscopy, to diagnose this disease and to achieve early removal of the angiofibroma, by a surgical procedure. It was concluded that the clinical diagnosis corresponded to the histopathological diagnosis, and that early surgical treatment is resolute in this condition.

  9. The brown adipocyte differentiation pathway in birds: An evolutionary road not taken

    Science.gov (United States)

    Mezentseva, Nadejda V; Kumaratilake, Jaliya S; Newman, Stuart A

    2008-01-01

    Background Thermogenic brown adipose tissue has never been described in birds or other non-mammalian vertebrates. Brown adipocytes in mammals are distinguished from the more common white fat adipocytes by having numerous small lipid droplets rather than a single large one, elevated numbers of mitochondria, and mitochondrial expression of the nuclear gene UCP1, the uncoupler of oxidative phosphorylation responsible for non-shivering thermogenesis. Results We have identified in vitro inductive conditions in which mesenchymal cells isolated from the embryonic chicken limb bud differentiate into avian brown adipocyte-like cells (ABALCs) with the morphological and many of the biochemical properties of terminally differentiated brown adipocytes. Avian, and as we show here, lizard species lack the gene for UCP1, although it is present in amphibian and fish species. While ABALCs are therefore not functional brown adipocytes, they are generated by a developmental pathway virtually identical to brown fat differentiation in mammals: both the common adipogenic transcription factor peroxisome proliferator-activated receptor-γ (PPARγ), and a coactivator of that factor specific to brown fat differentiation in mammals, PGC1α, are elevated in expression, as are mitochondrial volume and DNA. Furthermore, ABALCs induction resulted in strong transcription from a transfected mouse UCP1 promoter. Conclusion These findings strongly suggest that the brown fat differentiation pathway evolved in a common ancestor of birds and mammals and its thermogenicity was lost in the avian lineage, with the degradation of UCP1, after it separated from the mammalian lineage. Since this event occurred no later than the saurian ancestor of birds and lizards, an implication of this is that dinosaurs had neither UCP1 nor canonically thermogenic brown fat. PMID:18426587

  10. Naevoxanthoendothelioma (Synonym: Juvenile Xanthogranuloma

    Directory of Open Access Journals (Sweden)

    F Handa

    1978-01-01

    Full Text Available A case of naevoxanthoendothelioma juvenile xanthogranuloma is reported with rare features like late onset of the disease, involvement of liver and diffuse cutaneous lesions including cafe au lait spots and pigmented naevus. Final diagnosis could be achieved only on histopathology report.

  11. 37 NEW T-TYPE BROWN DWARFS IN THE CANADA-FRANCE BROWN DWARFS SURVEY

    International Nuclear Information System (INIS)

    Albert, Loic; Artigau, Etienne; Delorme, Philippe; Reyle, Celine; Forveille, Thierry; Delfosse, Xavier; Willott, Chris J.

    2011-01-01

    The Canada-France Brown Dwarfs Survey is an i'- and z'-band survey realized with MegaCam at the Canada-France-Hawaii Telescope that covers a surface area of 780 deg 2 . Image analysis is now completed while J-band follow-up campaigns are ∼90% done. The survey identified about 70 T dwarf candidates, of which 43 now have near-infrared spectra obtained with NIRI and GNIRS at Gemini and ISAAC at the Very Large Telescope. Six of these were previously published and we present here the 37 new discoveries, all T dwarfs. They range from T0 to T8.5 with four being of type T7 or later. Both newly identified T8 dwarfs are possibly high log (g) massive brown dwarfs of thin disk age. One T4.5 dwarf shows signs of sub-metallicity. We present proper motions and near-infrared photometry, and discuss about the most peculiar/interesting objects in some details.

  12. Integrated Circuitry: Catharine Brown across Gender, Race, and Religion

    Science.gov (United States)

    Nelson, Joshua B.

    2006-01-01

    This article talks about a Cherokee woman named Catharine Brown who was converted to Christianity by missionaries, as well as historical and theoretical contexts regarding the Cherokee. The author presents views from critics, such as Theda Perdue, Carolyn Ross Johnston, and Arnold Krupat, on Catharine Brown's experiences across spheres such as…

  13. The Impact of Banning Juvenile Gun Possession.

    OpenAIRE

    Marvell, Thomas B

    2001-01-01

    A 1994 federal law bans possession of handguns by persons under 18 years of age. Also in 1994, 11 states passed their own juvenile gun possession bans. Eighteen states had previously passed bans, 15 of them between 1975 and 1993. These laws were intended to reduce homicides, but arguments can be made that they have no effect on or that they even increase the homicide rate. This paper estimates the laws' impacts on various crime measures, primarily juvenile gun homicide victimizations and suic...

  14. Effect of moderate exercise on peritoneal neutrophils from juvenile rats.

    Science.gov (United States)

    Braz, Glauber Ruda; Ferreira, Diorginis Soares; Pedroza, Anderson Apolonio; da Silva, Aline Isabel; Sousa, Shirley Maria; Pithon-Curi, Tania Cristina; Lagranha, Claudia

    2015-09-01

    Previous studies showed that moderate exercise in adult rats enhances neutrophil function, although no studies were performed in juvenile rats. We evaluated the effects of moderate exercise on the neutrophil function in juvenile rats. Viability and neutrophils function were evaluated. Moderate exercise did not impair the viability and mitochondrial transmembrane potential of neutrophils, whereas there was greater reactive oxygen species production (164%; p < 0.001) and phagocytic capacity (29%; p < 0.05). Our results suggest that moderate exercise in juvenile rats improves neutrophil function, similar to adults.

  15. MR imaging of arthropathies of juvenile arthritis and hemophilia

    International Nuclear Information System (INIS)

    Yulish, B.S.; Lieberman, J.; Mulopoulos, G.P.; Strandjord, S.; Newman, A.; Goodfellow, D.; Bryan, P.J.; Modic, M.T.

    1986-01-01

    The arthropathies of juvenile arthritis and hemophilia have in common abnormal hyperplastic synovium leading to marginal bone erosion, articular cartilage destruction, subchondral bone exposure, and dissolution and ultimately collapse of the affected joint. The authors examined children and young adults with juvenile arthritis and hemophilia by MR imaging and found that they could identify hyperplastic synovium, articular cartilage lesions, bone erosions, and joint effusions. This has therapeutic implications since identification of progressive synovial hyperplasia and/or early cartilage or marginal bone erosion may lead to earlier synovectomy in patients with hemophilia or switch to second line drugs in patients with juvenile arthritis, in an attempt to prevent progressive joint destruction

  16. Chandra Captures Flare From Brown Dwarf

    Science.gov (United States)

    2000-07-01

    The first flare ever seen from a brown dwarf, or failed star, was detected by NASA's Chandra X-ray Observatory. The bright X-ray flare has implications for understanding the explosive activity and origin of magnetic fields of extremely low mass stars. Chandra detected no X-rays at all from LP 944-20 for the first nine hours of a twelve hour observation, then the source flared dramatically before it faded away over the next two hours. "We were shocked," said Dr. Robert Rutledge of the California Institute of Technology in Pasadena, the lead author on the discovery paper to appear in the July 20 issue of Astrophysical Journal Letters. "We didn't expect to see flaring from such a lightweight object. This is really the 'mouse that roared.'" Chandra LP 944-20 X-ray Image Press Image and Caption The energy emitted in the brown dwarf flare was comparable to a small solar flare, and was a billion times greater than observed X-ray flares from Jupiter. The flaring energy is believed to come from a twisted magnetic field. "This is the strongest evidence yet that brown dwarfs and possibly young giant planets have magnetic fields, and that a large amount of energy can be released in a flare," said Dr. Eduardo Martin, also of Caltech and a member of the team. Professor Gibor Basri of the University of California, Berkeley, the principal investigator for this observation, speculated that the flare "could have its origin in the turbulent magnetized hot material beneath the surface of the brown dwarf. A sub-surface flare could heat the atmosphere, allowing currents to flow and give rise to the X-ray flare -- like a stroke of lightning." LP 944-20 is about 500 million years old and has a mass that is about 60 times that of Jupiter, or 6 percent that of the Sun. Its diameter is about one-tenth that of the Sun and it has a rotation period of less than five hours. Located in the constellation Fornax in the southern skies, LP 944-20 is one of the best studied brown dwarfs because it is

  17. Juvenile Fibromyalgia: A Multidisciplinary Approach to Treatment.

    Science.gov (United States)

    Tesher, Melissa S

    2015-06-01

    A 14-year-old boy presented with months of severe widespread musculoskeletal pain. He was profoundly fatigued and unable to attend school. Laboratory evaluation, including complete blood count, comprehensive metabolic panel, inflammatory markers, and thyroid function, was unrevealing. Physical examination was also normal except for multiple tender points. The patient was diagnosed with juvenile primary fibromyalgia syndrome and referred for multidisciplinary treatment including physical therapy, exercise, and counseling, and his daily functioning gradually improves. Juvenile fibromyalgia is a complex syndrome that often severely limits patients' activities and can impede normal adolescent development. Effective treatment requires an understanding of the biologic, psychologic, and social factors contributing to the perpetuation of chronic pain. The author reviews the diagnostic criteria, pathophysiology, and treatment of juvenile fibromyalgia. Medications, particularly antidepressants and anticonvulsants, can be useful adjuncts to therapy. However, multimodal pain management including intensive physical therapy, exercise, counseling, and sleep hygiene is most effective in treating fibromyalgia. Copyright 2015, SLACK Incorporated.

  18. The Juvenile Addiction Risk Rating: Development and Initial Psychometrics

    Science.gov (United States)

    Powell, Michael; Newgent, Rebecca A.

    2016-01-01

    This article describes the development and psychometrics of the Juvenile Addiction Risk Rating. The Juvenile Addiction Risk Rating is a brief screening of addiction potential based on 10 risk factors predictive of youth alcohol and drug-related problems that assists examiners in more accurate treatment planning when self-report information is…

  19. Federal Juvenile Delinquency Programs: First Analysis and Evaluation. Volumes One and Two.

    Science.gov (United States)

    National Inst. for Juvenile Justice and Delinquency Prevention (Dept. of Justice/LEAA), Washington, DC.

    This publication outlines the activities of the Office of Juvenile Justice since its creation. It also reports on the entire Federal effort in delinquency prevention and juvenile justice. An introductory section describes the history and purpose of the Juvenile Justice and Delinquency Prevention Act of 1974 (Public Law 93-415). Other sections…

  20. Evolution of recidivism risk, using the YLS/CMI Inventory in a population of juvenile offenders

    Directory of Open Access Journals (Sweden)

    Keren Cuervo Gómez

    2017-05-01

    Full Text Available Risk assessment in juvenile recidivism allows understanding the specific factors that drives the juvenile to the commission of offences. Most of these juveniles will have a punctual relation with the justice system and only a small percentage will persist in this type of conducts. However, it seems that society perceives these juveniles as high risk offenders with high rates of recidivism. Hence, with the aim to clarify this topic, the objective of this paper is to explore the general risk of recidivism and the areas with higher risk, examining the risk of recidivism in a follow up period. Participants in this research were juveniles with a criminal record in the Juvenile Court of Castellón (N = 210. The Youth Level of Service/Case Management Inventory (YLS/CMI was administered to the juveniles along the follow up period of two years. Results show a majoritary profile of low risk juveniles, and a punctual relation with justice, rejecting the belief of dangerousness on juvenile offenders. On the contrary, juvenile recidivists with long criminal trajectories are in fact characterized by a high risk that would increase throughout the follow up period.

  1. Youth Drug Offenders: An Examination of Criminogenic Risk and Juvenile Recidivism

    OpenAIRE

    Papp, Jordan; Campbell, Christina; Onifade, Eyitayo; Anderson, Valerie; Davidson, William; Foster, Dawn

    2016-01-01

    Understanding the criminogenic risk factors and treatment needs of juvenile drug offenders is important because of the myriad negative outcomes that befall juveniles that are involved in drugs. A widely used juvenile risk assessment tool, the Youth Level of Service/Case Management Inventory (YLS/CMI) was utilized to explore criminogenic risk factors and treatment needs to predict recidivism. Demographic differences between drug and nondrug offenders were also examined. Results ...

  2. Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

    Science.gov (United States)

    Schulz, Tim J; Tseng, Yu-Hua

    2013-10-01

    Brown adipose tissue (BAT) is of great scientific interest as a potential target to treat obesity. The development of novel strategies to quantify brown fat thermogenesis in adult humans now enables minimally invasive assessment of novel pharmacotherapeutics. Input from the central nervous system via sympathetic efferents is widely regarded as the key controller of BAT-mediated thermogenesis in response to changes in body temperature or nutrient availability. More recently, however, it has become clear that locally secreted signals and endocrine factors originating from multiple organs can control the recruitment of brown adipocytes and, more importantly, induce thermogenesis in brown fat. Thus, they provide an attractive strategy to fine-tune brown fat thermogenesis independent of classical temperature sensing. Here, we summarize recent findings on bone morphogenetic protein signaling as an example of secreted factors in the regulation of brown adipocyte formation and systemic control of energy metabolism. We further highlight endocrine communication routes between the different types of brown adipocytes and other organs that contribute to regulation of thermogenesis. Thus, emerging evidence suggests that the classical mechanisms of central temperature sensing and sympathetic nervous system-driven thermogenesis are complemented by local and endocrine signals to determine systemic energy homeostasis. © 2013 New York Academy of Sciences.

  3. Improvement Effect of Dewaxed Brown Rice on Constipation in Antibiotic-treated Mice.

    Science.gov (United States)

    Inagawa, Hiroyuki; Saika, Toshiyuki; Nishiyama, Naoki; Nisizawa, Takashi; Kohchi, Chie; Uenobe, Maya; Soma, Gen-Ichiro

    2017-01-01

    A decrease in gastrointestinal motility causing weakened lipopolysaccharide (LPS) - toll-like receptor (TLR)4 signaling along with a decline in the number of enteric bacteria is known to be a cause of constipation due to the administration of antibiotics. A new type of brown rice with its wax layer removed, resulting in quick-cooking and tasty product, contains 100-times more LPS than polished white rice. In this study, the improvement effect on constipation due to intake of dewaxed brown rice was examined. Dewaxed brown rice was prepared at Toyo Rice from brown rice. Mice were given powdered feed to which powdered rice containing 0-50% of dewaxed brown rice was added. Antibiotics were administered for 10 or 27 days in drinking water containing vancomycin, metronidazole and neomycin. LPS, used as a control, was freely provided in drinking water. The defecation frequency, stool weight per hour and body weight were determined on the last day. Although the 10-day administration of antibiotics reduced the stool weight per hour to half, the dewaxed brown rice and LPS groups showed a trend towards improvement at a level comparable to the group receiving no antibiotics. The body weight significantly decreased after the 27-day administration of antibiotics but was improved in the 50% dewaxed brown rice group at a level comparable to the group receiving no antibiotics. Though the defecation frequency and wet and dry stool weights per hour were reduced by as much as 50% in the group receiving antibiotics, a significant improvement in constipation was observed in the 50% dewaxed brown rice group. As the improvement effect of dewaxed brown rice on body weight loss and constipation caused by the long-term administration of antibiotics has been confirmed in animal experimentation, the introduction of dewaxed brown rice as a staple food to patients under long-term antibiotic treatment may improve constipation. Copyright© 2017, International Institute of Anticancer Research (Dr

  4. Improvement Effect of Dewaxed Brown Rice on Constipation in Antibiotic-treated Mice

    Science.gov (United States)

    INAGAWA, HIROYUKI; SAIKA, TOSHIYUKI; NISHIYAMA, NAOKI; NISIZAWA, TAKASHI; KOHCHI, CHIE; UENOBE, MAYA; SOMA, GEN-ICHIRO

    2017-01-01

    Background/Aim: A decrease in gastrointestinal motility causing weakened lipopolysaccharide (LPS) – toll-like receptor (TLR)4 signaling along with a decline in the number of enteric bacteria is known to be a cause of constipation due to the administration of antibiotics. A new type of brown rice with its wax layer removed, resulting in quick-cooking and tasty product, contains 100-times more LPS than polished white rice. In this study, the improvement effect on constipation due to intake of dewaxed brown rice was examined. Materials and Methods: Dewaxed brown rice was prepared at Toyo Rice from brown rice. Mice were given powdered feed to which powdered rice containing 0-50% of dewaxed brown rice was added. Antibiotics were administered for 10 or 27 days in drinking water containing vancomycin, metronidazole and neomycin. LPS, used as a control, was freely provided in drinking water. The defecation frequency, stool weight per hour and body weight were determined on the last day. Results: Although the 10-day administration of antibiotics reduced the stool weight per hour to half, the dewaxed brown rice and LPS groups showed a trend towards improvement at a level comparable to the group receiving no antibiotics. The body weight significantly decreased after the 27-day administration of antibiotics but was improved in the 50% dewaxed brown rice group at a level comparable to the group receiving no antibiotics. Though the defecation frequency and wet and dry stool weights per hour were reduced by as much as 50% in the group receiving antibiotics, a significant improvement in constipation was observed in the 50% dewaxed brown rice group. Conclusion: As the improvement effect of dewaxed brown rice on body weight loss and constipation caused by the long-term administration of antibiotics has been confirmed in animal experimentation, the introduction of dewaxed brown rice as a staple food to patients under long-term antibiotic treatment may improve constipation. PMID

  5. Management of brown bears (Ursus arctos) in Europe.

    OpenAIRE

    Klenzendorf, Sybille A.

    1997-01-01

    Management of Brown Bears (Ursus arctos) in Europe. Sybille A. Klenzendorf (Abstract) Successful conservation of brown bears (Ursus arctos) in Europe is associated with public acceptance of damages caused by bears. Recent increases in sheep depredation and beehive damage in central Austria resulted in the deaths of two bears there. Since bear numbers are low in most European populations, alternatives to the elimination of problem bears associated with dam...

  6. Juvenile psammomatoid ossifying fibroma: An unusual case report

    Directory of Open Access Journals (Sweden)

    Nidhi Yadav

    2013-01-01

    Full Text Available Ossifying fibromas are well-demarcated benign fibro-osseous tumors of craniofacial skeleton most often in the jaws. It has two types, conventional and juvenile ossifying fibroma (JOF. JOF is considered a separate entity from ossifying fibroma due to its locally aggressive behavior and tendency to occur at a young age. Two subtypes of JOF, i.e., juvenile psammomatoid ossifying fibroma (JPOF and juvenile trabecular ossifying fibroma have been identified on the basis of histology 70% of the JPOF occur in the paranasal sinuses, 20% in the maxilla and only 10% in the mandible. Here, we report a case of JPOF in a 14-year-old girl causing an asymptomatic expansile swelling in the right mandibular posterior region, which is a rare site for this tumor.

  7. Highly Viscous States Affect the Browning of Atmospheric Organic Particulate Matter.

    Science.gov (United States)

    Liu, Pengfei; Li, Yong Jie; Wang, Yan; Bateman, Adam P; Zhang, Yue; Gong, Zhaoheng; Bertram, Allan K; Martin, Scot T

    2018-02-28

    Initially transparent organic particulate matter (PM) can become shades of light-absorbing brown via atmospheric particle-phase chemical reactions. The production of nitrogen-containing compounds is one important pathway for browning. Semisolid or solid physical states of organic PM might, however, have sufficiently slow diffusion of reactant molecules to inhibit browning reactions. Herein, organic PM of secondary organic material (SOM) derived from toluene, a common SOM precursor in anthropogenically affected environments, was exposed to ammonia at different values of relative humidity (RH). The production of light-absorbing organonitrogen imines from ammonia exposure, detected by mass spectrometry and ultraviolet-visible spectrophotometry, was kinetically inhibited for RH atmospheric brown carbon production and associated influences on energy balance.

  8. Chewing lice Trichodectes pinguis pinguis in Scandinavian brown bears (Ursus arctos

    Directory of Open Access Journals (Sweden)

    Núria Fandos Esteruelas

    2016-08-01

    Full Text Available In April 2014 and 2015, we noted localized alopecia (neck, forelimbs, and chest and hyperpigmentation on two adult brown bears (Ursus arctos captured in central-south Sweden for ecological studies under the Scandinavian Brown Bear Research Project. In spring 2015, a brown bear was shot because of human-wildlife conflict in the same region. This bear also had extensive alopecia and hyperpigmentation. Ectoparasites were collected from the affected skin areas in all three individuals and preserved in ethanol for identification. Based on morphological characteristics, the lice were identified as Trichodectes spp. and Trichodectes pinguis pinguis. To our knowledge, these are the first reported cases of chewing lice in free-ranging brown bears in Scandinavia.

  9. Juvenile idiopathic arthritis – an update on its diagnosis and ...

    African Journals Online (AJOL)

    2015-12-03

    Dec 3, 2015 ... Juvenile idiopathic arthritis (JIA) is the most common form of chronic arthritis in children and the most ... A swollen knee and uveitis in a young girl, for instance, is ..... Methotrexate for treating juvenile idiopathic arthritis.

  10. Brown dwarf accretion: Nonconventional star formation over very long timescales

    Directory of Open Access Journals (Sweden)

    Ćirković Milan M.

    2005-01-01

    Full Text Available We investigate the process of accretion of interstellar gas by the Galactic population of brown dwarfs over very long timescales typical for physical eschatology. In particular, we use the classical Hoyle-Lyttleton-Bondi accretion model to investigate the rate at which brown dwarfs collect enough additional mass to become red dwarfs, accretion-induced changes in the mass function of the low- mass objects, and the corresponding accretion heating of brown dwarfs. In addition, we show how we can make the definition of the final mass function for stellar objects more precise.

  11. Dependent vs. independent juvenile survival: contrasting drivers of variation and the buffering effect of parental care.

    Science.gov (United States)

    Dybala, Kristen E; Gardali, Thomas; Eadie, John M

    2013-07-01

    Juvenile survival is often found to be more sensitive than adult survival to variation in environmental conditions, and variation in juvenile survival can have significant impacts on population growth rates and viability. Therefore, understanding the population-level effects of environmental changes requires understanding the effects on juvenile survival. We hypothesized that parental care will buffer the survival of dependent juveniles from variation in environmental conditions, while the survival of independent juveniles will respond more strongly to environmental variation and, in turn, drive the overall variation in annual juvenile survival. We tested this parental-care hypothesis using a 30-year mark-recapture data set to model the survival of juvenile Song Sparrows (Melospiza melodia) during the dependent and independent stages. We examined the effects of weather, density, and cohort mean fledge date and body mass on annual variation in survival during the first 12 weeks after fledging, as well as effects of individual fledge date and body mass on individual variation in survival. The primary driver of annual variation in juvenile survival was precipitation during the previous rainy season, consistent with an effect on food availability, which had a strong positive effect on the survival of independent juveniles, but no effect on dependent juveniles. We also found strong support for effects of body mass and fledge date on individual survival probability, including striking differences in the effect of fledge date by stage. Our results provided evidence that different mechanisms influence juvenile survival during each stage of fledgling development, and that parental care buffers the survival of dependent juveniles from variation in environmental conditions. Consequently, variation in juvenile survival was driven by independent juveniles, not dependent juveniles, and studies focused only on survival during the dependent stage may not be able to detect the

  12. Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

    Directory of Open Access Journals (Sweden)

    Tobias Fromme

    2018-02-01

    Full Text Available Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation. Methods: With mass spectrometry, purine nucleotide metabolites were quantified in cellular homogenates and supernatants of cultured primary brown adipocytes. We also determined oxygen consumption in response to a β-adrenergic agonist. Results: Upon adrenergic activation, brown adipocytes decreased the intracellular concentration of inhibitory nucleotides (ATP, ADP, GTP and GDP and released the respective degradation products. At the same time, an increase in cellular calcium occurred. None of these phenomena occurred in white adipocytes or myotubes. The brown adipocyte expression of enzymes implicated in purine metabolic remodeling is altered upon cold exposure. Pharmacological and genetic interference of purine metabolism altered uncoupling protein 1 mediated uncoupled respiration. Conclusion: Adrenergic stimulation of brown adipocytes lowers the intracellular concentration of purine nucleotides, thereby contributing to uncoupling protein 1 activation. Keywords: Purine nucleotides, Uncoupling protein 1, Brown adipose tissue, Non-shivering thermogenesis, HILIC-MS/MS, Guanosine monophosphate reductase

  13. Intravitreally Injected Anti-VEGF Antibody Reduces Brown Fat in Neonatal Mice.

    Science.gov (United States)

    Jo, Dong Hyun; Park, Sung Wook; Cho, Chang Sik; Powner, Michael B; Kim, Jin Hyoung; Fruttiger, Marcus; Kim, Jeong Hun

    2015-01-01

    Anti-vascular endothelial growth factor (VEGF) agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a vasoproliferative retinal disorder in premature infants. However, the risks of systemic complications after intravitreal injection of anti-VEGF antibody in infants are not well understood. In this study, we show that intravitreally injected anti-VEGF antibody is transported into the systemic circulation into the periphery where it reduces brown fat in neonatal C57BL/6 mice. A considerable amount of anti-VEGF antibody was detected in serum after intravitreal injection. Furthermore, in interscapular brown adipose tissue, we found lipid droplet accumulation, decreased VEGF levels, loss of vascular network, and decreased expression of mitochondria-related genes, Ppargc1a and Ucp1, all of which are characteristics of "whitening" of brown fat. With increasing age and body weight, brown fat restored its morphology and vascularity. Our results show that there is a transient, but significant impact of intravitreally administered anti-VEGF antibody on brown adipose tissue in neonatal mice. We suggest that more attention should be focused on the metabolic and developmental significance of brown adipose tissue in bevacizumab treated retinopathy of prematurity infants.

  14. Intravitreally Injected Anti-VEGF Antibody Reduces Brown Fat in Neonatal Mice.

    Directory of Open Access Journals (Sweden)

    Dong Hyun Jo

    Full Text Available Anti-vascular endothelial growth factor (VEGF agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a vasoproliferative retinal disorder in premature infants. However, the risks of systemic complications after intravitreal injection of anti-VEGF antibody in infants are not well understood. In this study, we show that intravitreally injected anti-VEGF antibody is transported into the systemic circulation into the periphery where it reduces brown fat in neonatal C57BL/6 mice. A considerable amount of anti-VEGF antibody was detected in serum after intravitreal injection. Furthermore, in interscapular brown adipose tissue, we found lipid droplet accumulation, decreased VEGF levels, loss of vascular network, and decreased expression of mitochondria-related genes, Ppargc1a and Ucp1, all of which are characteristics of "whitening" of brown fat. With increasing age and body weight, brown fat restored its morphology and vascularity. Our results show that there is a transient, but significant impact of intravitreally administered anti-VEGF antibody on brown adipose tissue in neonatal mice. We suggest that more attention should be focused on the metabolic and developmental significance of brown adipose tissue in bevacizumab treated retinopathy of prematurity infants.

  15. How body mass and lifestyle affect juvenile biomass production in placental mammals.

    Science.gov (United States)

    Sibly, Richard M; Grady, John M; Venditti, Chris; Brown, James H

    2014-02-22

    In mammals, the mass-specific rate of biomass production during gestation and lactation, here called maternal productivity, has been shown to vary with body size and lifestyle. Metabolic theory predicts that post-weaning growth of offspring, here termed juvenile productivity, should be higher than maternal productivity, and juveniles of smaller species should be more productive than those of larger species. Furthermore because juveniles generally have similar lifestyles to their mothers, across species juvenile and maternal productivities should be correlated. We evaluated these predictions with data from 270 species of placental mammals in 14 taxonomic/lifestyle groups. All three predictions were supported. Lagomorphs, perissodactyls and artiodactyls were very productive both as juveniles and as mothers as expected from the abundance and reliability of their foods. Primates and bats were unproductive as juveniles and as mothers, as expected as an indirect consequence of their low predation risk and consequent low mortality. Our results point the way to a mechanistic explanation for the suite of correlated life-history traits that has been called the slow-fast continuum.

  16. The Juvenile Hafnium Isotope Signal as a Record of Supercontinent Cycles

    Science.gov (United States)

    Gardiner, Nicholas J.; Kirkland, Christopher L.; van Kranendonk, Martin J.

    2016-12-01

    Hf isotope ratios measured in igneous zircon are controlled by magmatic source, which may be linked to tectonic setting. Over the 200-500 Myr periodicity of the supercontinent cycle - the principal geological phenomenon controlling prevailing global tectonic style - juvenile Hf signals, i.e. most radiogenic, are typically measured in zircon from granites formed in arc settings (crustal growth), and evolved zircon Hf signals in granites formed in continent-collision settings (crustal reworking). Interrogations of Hf datasets for excursions related to Earth events commonly use the median value, however this may be equivocal due to magma mixing. The most juvenile part of the Hf signal is less influenced by crustal in-mixing, and arguably a more sensitive archive of Earth’s geodynamic state. We analyze the global Hf dataset for this juvenile signal, statistically correlating supercontinent amalgamation intervals with evolved Hf episodes, and breakup leading to re-assembly with juvenile Hf episodes. The juvenile Hf signal is more sensitive to Pangaea and Rodinia assembly, its amplitude increasing with successive cycles to a maximum with Gondwana assembly which may reflect enhanced subduction-erosion. We demonstrate that the juvenile Hf signal carries important information on prevailing global magmatic style, and thus tectonic processes.

  17. Fuel briquettes from brown coals of Yakutia

    Energy Technology Data Exchange (ETDEWEB)

    L.A. Nikolaeva; V.G. Latyshev; O.N. Burenina [Russian Academy of Sciences, Yakutsk (Russian Federation). Institute of Oil and Gas Problems

    2009-04-15

    Experimental data on the development of technology for the manufacture of briquetted fuel from brown coals with the use of various petroleum binders are presented. The influence of the moisture content, the coal particle-size composition, the binder type and concentration, the compacting pressure, and heat treatment regimes on the mechanical properties of the materials was studied. The optimal compositions and optimal values of the engineering parameters for the production of graded briquetted fuel from brown coals of the Kangalassy deposit in the Republic of Sakha (Yakutia) were established.

  18. Brown dwarfs in retrogradely precessing cataclysmic variables?

    Directory of Open Access Journals (Sweden)

    Martin E.L.

    2011-07-01

    Full Text Available We compare Smoothed Particle Hydrodynamic simulations of retrogradely precessing accretion disks that have a white dwarf primary and a main sequence secondary with observational data and with theory on retrograde precession via tidal torques like those by the Moon and the Sun on the Earth [1, 2]. Assuming the primary does not accrete much of the mass lost from the secondary, we identify the theoretical low mass star/brown dwarf boundary. We find no observational candidates in our study that could qualify as brown dwarfs.

  19. Cellulose Degradation by Cellulose-Clearing and Non-Cellulose-Clearing Brown-Rot Fungi

    OpenAIRE

    Highley, Terry L.

    1980-01-01

    Cellulose degradation by four cellulose-clearing brown-rot fungi in the Coniophoraceae—Coniophora prasinoides, C. puteana, Leucogyrophana arizonica, and L. olivascens—is compared with that of a non-cellulose-clearing brown-rot fungus, Poria placenta. The cellulose- and the non-cellulose-clearing brown-rot fungi apparently employ similar mechanisms to depolymerize cellulose; most likely a nonenzymatic mechanism is involved.

  20. [Sex-linked juvenile retinoschisis].

    Science.gov (United States)

    François, P; Turut, P; Soltysik, C; Hache, J C

    1976-02-01

    About 13 observations of sexe linked juvenile retinoschisis, the authors describe the ophthalmoscopic, fluorographic and functional aspects of the disease whose caracteristics are:--its sexe linked recessive heredity; --its clinical characterestics associating: a microcystic macular degeneration, peripheral retinal lesions, vitreous body alterations, --an electroretinogram of the negative type.

  1. The Content Validity of Juvenile Psychopathy: An Empirical Examination

    Science.gov (United States)

    Lynam, Donald R.; Derefinko, Karen J.; Caspi, Avshalom; Loeber, Rolf; Stouthamer-Loeber, Magda

    2007-01-01

    This study examined the content validity of a juvenile psychopathy measure, the Childhood Psychopathy Scale (CPS; D. R. Lynam, 1997), based on a downward translation of an adult instrument, the Hare Psychopathy Checklist-Revised (PCL-R; R. D. Hare, 1991). The CPS was compared with two other indices of juvenile psychopathy: (a) an index derived…

  2. Juvenile Dermatomyositis in a Nigerian Girl: a Case Report ...

    African Journals Online (AJOL)

    Juvenile Dermatomyositis in a Nigerian Girl: a Case Report. MG Mustapha, MG Ashir, AA Mayun, Y Machoco, AB Ibrahim. Abstract. A case of Juvenile dermatomyositis (JDM) in a 10 year old Nigerian girl is herein reported to discuss some of the features of the disease and challenges in management of such a rare but ...

  3. Growth and Survival of Catfish ( Clarias anguillaris ) Juveniles Fed ...

    African Journals Online (AJOL)

    Juveniles of catfish, Clarias anguillaris (mean weight, 119.8g) were fed unconventional diets for ten weeks in outdoor hapas (net cages, 1m3 dimension) and the growth responses and feed utilization by the juveniles were compared. The experimental diets were (i) live maggots, (ii) live tilapia fry, (iii) commercial catfish feed ...

  4. Dating Violence and Girls in the Juvenile Justice System

    Science.gov (United States)

    Kelly, Patricia J.; Cheng, An-Lin; Peralez-Dieckmann, Esther; Martinez, Elisabeth

    2009-01-01

    The purpose of this study is to explore the prevalence and associated behaviors of dating violence among a population of girls in the juvenile justice system. A sample of 590 girls from an urban juvenile justice system completed a questionnaire assessing attitudes and self-efficacy about and occurrence of dating violence. The analysis developed a…

  5. Motivation, Prosocial and Antisocial Behaviors of Juveniles in Compare to Wellbehaved Peers

    Directory of Open Access Journals (Sweden)

    Hubert Kupiec

    2013-12-01

    Full Text Available The article contain results of research which participants were 104 juvenile delinquent and 294 adolescents from public schools. The statistic analyses show that juveniles have similar level of prosocial motivation as their well behaving peers from schools. However, gender is significant differentiation factor because girls have higher prosocial motivation and more frequently behave prosocially than boys in both compared groups. Juveniles exhibit less prosocial behavior than antisocial to relatives and friends, compared to their peers from schools, also. This paper include discussion of results and practical recommendations how we can develope motivation and prosocial behavior among juvenile delinquents.

  6. Do burn centers provide juvenile firesetter intervention?

    Science.gov (United States)

    Ahrns-Klas, Karla S; Wahl, Wendy L; Hemmila, Mark R; Wang, Stewart C

    2012-01-01

    Juvenile firesetting activity accounts for a significant number of annual injuries and property damage, yet there is sparse information on intervention in the burn literature. To quantify juvenile firesetting intervention (JFSI) in burn centers, a 23-question survey was sent to all directors listed in the American Burn Association Burn Care Facilities Directory.Sixty-four out of 112 (57%) surveys were returned. This represents responses from 79% of currently verified burn centers. When queried on interventions provided to a juvenile firesetter admitted to their unit, 38% report having their own JFSI program and 38% refer the child to fire services. Two thirds of units without a JFSI program treat pediatric patients. Units that previously had a JFSI program report lack of staffing and funding as most common reasons for program discontinuation. Almost all (95%) stated that a visual tool demonstrating legal, financial, social, future, and career ramifications associated with juvenile firesetting would be beneficial to their unit. Many burn units that treat pediatric patients do not have JFSI and rely on external programs operated by fire services. Existing JFSI programs vary greatly in structure and method of delivery. Burn centers should be involved in JFSI, and most units would benefit from a new video toolkit to assist in providing appropriate JFSI. Study results highlight a need for burn centers to collaborate on evaluating effectiveness of JFSI programs and providing consistent intervention materials based on outcomes research.

  7. Constraints on the brown dwarf mass function from optical and infrared searches

    International Nuclear Information System (INIS)

    Probst, R.G.

    1986-01-01

    Photometric surveys of faint proper motion stars and searches for infrared binary companions have identified a few very low luminosity objects. The author considers how these searches may constrain the brown dwarf mass function. An astrophysically plausible brown dwarf population is defined which yields a dark mass density = 0.5 x the observed density. Using the sensitivity and other limits of various surveys, the expected numbers of observable brown dwarfs are obtained from the model population for comparison with actual results. Reasonable improvement in search protocol could yield statistically significant tests of the brown dwarf mass function. (author)

  8. Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.

    Science.gov (United States)

    Cohen, Paul; Spiegelman, Bruce M

    2015-07-01

    The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways. We discuss here some of the thermodynamic and cellular aspects of recent progress in brown fat research. This includes studies of developmental lineages of UCP1(+) adipocytes, including the discovery of beige fat cells, a new thermogenic cell type. We also discuss the physiology and transcriptional control of brown and beige cells in rodents and the state of current knowledge about human brown fat. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  9. Coblation-assisted endonasal endoscopic resection of juvenile nasopharyngeal angiofibroma.

    Science.gov (United States)

    Ye, L; Zhou, X; Li, J; Jin, J

    2011-09-01

    Juvenile nasopharyngeal angiofibroma may be successfully resected using endoscopic techniques. However, the use of coblation technology for such resection has not been described. This study aimed to document cases of Fisch class I juvenile nasopharyngeal angiofibroma with limited nasopharyngeal and nasal cavity extension, which were completely resected using an endoscopic coblation technique. We retrospectively studied 23 patients with juvenile nasopharyngeal angiofibroma who underwent resection with either traditional endoscopic instruments (n = 12) or coblation (n = 11). Intra-operative blood loss and overall operative time were recorded. The mean tumour resection time for coblation and traditional endoscopic instruments was 87 and 136 minutes, respectively (t = 9.962, p angiofibroma (Fisch class I), with good surgical margins and minimal blood loss.

  10. Students Use VLA to Make Startling Brown-Dwarf Discovery

    Science.gov (United States)

    2001-03-01

    A group of summer students making a long-shot astronomical gamble with the National Science Foundation's (NSF) Very Large Array (VLA) have found the first radio emission ever detected from a brown dwarf, an enigmatic object that is neither a star nor a planet, but something in between. Their surprising discovery is forcing experts to re-think their theories about how brown dwarfs work. The Very Large Array "Many astronomers are surprised at this discovery, because they didn't expect such strong radio emission from this object," said Shri Kulkarni, a Caltech professor who was on the team that first discovered a brown dwarf in 1995, and advisor to one of the students. "What is so cool is that this is research that probably nobody else would have tried to do because of its low chance of success. That made it ideal for summer students -- we had almost nothing to lose," said Kate Becker, a student at Oberlin College in Ohio. "The radio emission these students discovered coming from this brown dwarf is 10,000 times stronger than anyone expected," said Dale Frail, an astronomer at the National Radio Astronomy Observatory (NRAO) in Socorro, NM. "This student project is going to open up a whole new area of research for the VLA," Frail added. The students, in addition to Becker, are: Edo Berger from Caltech; Steven Ball from New Mexico Tech in Socorro, NM; Melanie Clarke from Carleton College in Northfield, MN; Therese Fukuda from the University of Denver; Ian Hoffman from the University of New Mexico in Albuquerque; Richard Mellon from The Pennsylvania State University; Emmanuel Momjian from the University of Kentucky; Nathanial Murphy from Amherst College in Amherst, MA; Stacey Teng from the University of Maryland; Timothy Woodruff from Southwestern University in Georgetown, TX; Ashley Zauderer from Agnes Scott College in Decatur, GA; and Robert Zavala from New Mexico State University in Las Cruces, NM. Frail also is an author of the research paper, published in the March

  11. A Very Cool Pair of Brown Dwarfs

    Science.gov (United States)

    2011-03-01

    Observations with the European Southern Observatory's Very Large Telescope, along with two other telescopes, have shown that there is a new candidate for the coldest known star: a brown dwarf in a double system with about the same temperature as a freshly made cup of tea - hot in human terms, but extraordinarily cold for the surface of a star. This object is cool enough to begin crossing the blurred line dividing small cold stars from big hot planets. Brown dwarfs are essentially failed stars: they lack enough mass for gravity to trigger the nuclear reactions that make stars shine. The newly discovered brown dwarf, identified as CFBDSIR 1458+10B, is the dimmer member of a binary brown dwarf system located just 75 light-years from Earth [1]. The powerful X-shooter spectrograph on ESO's Very Large Telescope (VLT) was used to show that the composite object was very cool by brown dwarf standards. "We were very excited to see that this object had such a low temperature, but we couldn't have guessed that it would turn out to be a double system and have an even more interesting, even colder component," said Philippe Delorme of the Institut de planétologie et d'astrophysique de Grenoble (CNRS/Université Joseph Fourier), a co-author of the paper. CFBDSIR 1458+10 is the coolest brown dwarf binary found to date. The dimmer of the two dwarfs has now been found to have a temperature of about 100 degrees Celsius - the boiling point of water, and not much different from the temperature inside a sauna [2]. "At such temperatures we expect the brown dwarf to have properties that are different from previously known brown dwarfs and much closer to those of giant exoplanets - it could even have water clouds in its atmosphere," said Michael Liu of the University of Hawaii's Institute for Astronomy, who is lead author of the paper describing this new work. "In fact, once we start taking images of gas-giant planets around Sun-like stars in the near future, I expect that many of them

  12. Platelet function in brown bear (Ursus arctos compared to man

    Directory of Open Access Journals (Sweden)

    Särndahl Eva

    2010-06-01

    Full Text Available Abstract Background Information on hemostasis and platelet function in brown bear (Ursus arctos is of importance for understanding the physiological, protective changes during hibernation. Objective The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. Methods Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. Results Blood samples were collected from 6 bears (3 females between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. Conclusion Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.

  13. A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans.

    Science.gov (United States)

    Miyakawa, Hitoshi; Toyota, Kenji; Hirakawa, Ikumi; Ogino, Yukiko; Miyagawa, Shinichi; Oda, Shigeto; Tatarazako, Norihisa; Miura, Toru; Colbourne, John K; Iguchi, Taisen

    2013-01-01

    Juvenile hormone is an essential regulator of major developmental and life history events in arthropods. Most of the insects use juvenile hormone III as the innate juvenile hormone ligand. By contrast, crustaceans use methyl farnesoate. Despite this difference that is tied to their deep evolutionary divergence, the process of this ligand transition is unknown. Here we show that a single amino-acid substitution in the receptor Methoprene-tolerant has an important role during evolution of the arthropod juvenile hormone pathway. Microcrustacea Daphnia pulex and D. magna share a juvenile hormone signal transduction pathway with insects, involving Methoprene-tolerant and steroid receptor coactivator proteins that form a heterodimer in response to various juvenoids. Juvenile hormone-binding pockets of the orthologous genes differ by only two amino acids, yet a single substitution within Daphnia Met enhances the receptor's responsiveness to juvenile hormone III. These results indicate that this mutation within an ancestral insect lineage contributed to the evolution of a juvenile hormone III receptor system.

  14. Psychopathology and personality in juvenile sexual homicide offenders.

    Science.gov (United States)

    Myers, W C; Blashfield, R

    1997-01-01

    This project describes the psychopathology and personality findings in 14 juveniles who committed sexual homicide. These incarcerated youth were assessed using a structured interview, a personality assessment instrument, correctional files review, and an author-designed clinical interview. Nearly all of these youth met DSM-III-R conduct disorder criteria at the time of the crime. The presence of personality disorders and moderately high psychopathy scores at follow-up were common. Two-thirds of these youth reported the presence of violent sexual fantasies before their crimes. Weapons, most often knives, were used by these juvenile sexual murderers to kill known victims in a majority of the cases. They usually acted alone and selected a low risk victim. These findings suggest that juvenile sexual murderers are an emotionally and behaviorally disturbed population with identifiable psychopathology, personality disturbances, and criminal patterns.

  15. Transcriptomic events associated with internal browning of apple during postharvest storage

    OpenAIRE

    Mellidou, Ifigeneia; Buts, Kim; Hatoum, Darwish; Ho, Quang Tri; Johnston, Jason W; Watkins, Christopher B; Schaffer, Robert J; Gapper, Nigel E; Giovannoni, Jim J; Rudell, David R; Hertog, Maarten LATM; Nicolai, Bart M

    2014-01-01

    Background Postharvest ripening of apple (Malus x domestica) can be slowed down by low temperatures, and a combination of low O2 and high CO2 levels. While this maintains the quality of most fruit, occasionally storage disorders such as flesh browning can occur. This study aimed to explore changes in the apple transcriptome associated with a flesh browning disorder related to controlled atmosphere storage using RNA-sequencing techniques. Samples from a browning-susceptible cultivar (‘Braeburn...

  16. Fatores de risco associados à calcinose na dermatomiosite juvenil Risk factors associated with calcinosis of juvenile dermatomyositis

    Directory of Open Access Journals (Sweden)

    Adriana M. E. Sallum

    2008-02-01

    Full Text Available OBJETIVO: Identificar fatores de risco associados à calcinose em crianças e adolescentes com dermatomiosite juvenil. MÉTODOS: Prontuários de 54 pacientes com dermatomiosite juvenil foram estudados. Foram avaliados dados demográficos; características clínicas: grau de força muscular (I a V do Medical Research Council, presença de comprometimentos pulmonar (distúrbio ventilatório restritivo com presença ou ausência do anticorpo anti-Jo-1, gastrointestinal (refluxo gastroesofágico e cardíaco (pericardite e/ou miocardite; exames laboratoriais: elevação de enzimas musculares (creatinoquinase, aspartato aminotransferase, alanina aminotransferase e desidrogenase lática e terapias utilizadas: corticoterapia isolada ou associada à cloroquina e/ou imunossupressor. Os pacientes foram divididos em dois grupos de acordo com a presença ou ausência de calcinose e foram avaliados através de análise univariada e multivariada. RESULTADOS: Calcinose foi evidenciada em 23 (43% pacientes, sendo em seis (26% antes do diagnóstico e em 17 (74% após. A análise univariada revelou que comprometimentos cardíaco (p = 0,01 e pulmonar (p = 0,02 e necessidade da utilização de um ou mais imunossupressores (metotrexato, ciclosporina A e/ou pulsoterapia com ciclofosfamida endovenosa no tratamento da dermatomiosite juvenil (p = 0,03 foram associados com uma maior incidência de calcinose. A análise multivariada mostrou que comprometimento cardíaco (OR = 15,56; IC95% 1,59-152,2 e uso de um ou mais imunossupressores (OR = 4,01; IC95% 1,08-14,87 foram as únicas variáveis independentes associadas à presença de calcinose. CONCLUSÕES: O aparecimento da calcinose foi freqüente na dermatomiosite juvenil, habitualmente na evolução da doença. A calcinose foi associada aos casos mais graves, que apresentaram envolvimento cardíaco e necessitaram da utilização de imunossupressores no seu tratamento.OBJECTIVE: To identify risk factors associated with

  17. Sorghum Brown Midrib Mutants, Tools to Improve Biomass for Biofuels

    Science.gov (United States)

    To improve sorghum for cellulosic bioenergy uses, brown midrib mutants are being investigated for their ability to increase the conversion efficiency of biomass. brown midrib 6 and 12 (bmr6 and 12) mutants affect monolignol biosynthesis resulting in reduced lignin content and altered lignin composi...

  18. Statistical indicators and trends in juvenile delinquency in modern Russia

    Directory of Open Access Journals (Sweden)

    Yuzikhanova E.G.

    2014-12-01

    Full Text Available Statistics of juvenile delinquency in Russia for ten years, allowing to determine its current trends, is presented. It’s noted that earlier the proportion of juveniles among all criminals was about 11-12%. During the period from 2003 to 2013 the proportion of juveniles in the total number of identified offenders decreased to 6%. Despite the reduction in the number of crimes committed by this category of persons, for several years the largest criminal activity is maintained in the age group 16-17 years (70%. Smaller proportion is the age group 14-15 years, there’s a reduction in the number of committed crimes: from 49,300 in 2000 to 19,700 in 2013. Over the same period, the number of reported crimes committed by minors or with their complicity decreased almost three times. With all the ambiguity of attitude to the considered problem, the author defines the role of criminal law policy of the state in response to trends in juvenile crime taking into account its specificity, caused by the complex of interrelated factors related to age, social, psychological characteristics of juveniles as a special social group, the originality of their social status. The legislative novel is considered: the punishment in the form of arrest is not imposed on persons under the age of eighteen by the time of court verdict. It’s summarized that the problems of juvenile delinquency are only partly solved by the humanization of criminal law policy of the state in order to restore social justice, correct the convict and prevent new crimes commission.

  19. Agaricus bisporus browning: a review

    NARCIS (Netherlands)

    Jolivet, S.; Arpin, N.; Wichers, H.J.; Pellon, G.

    1998-01-01

    Agaricus bisporus browning is a common and economically detrimental phenomenon, in which melanogenic phenols are enzymically processed into quinones, which evolve eventually to melanins. This review deals with the two fundamental sides of this process, enzyme(s) and phenolic substrates. Mushroom

  20. Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

    Directory of Open Access Journals (Sweden)

    Lu Yao

    2017-07-01

    Full Text Available Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological “whitening” of brown fat, reduced oxygen (O2 consumption, obesity, decreased core body temperature, and cold sensitivity. Fat SIRT6-deleted mice exhibit increased blood glucose levels, severe insulin resistance, and hepatic steatosis. Moreover, SIRT6 deficiency inhibits the browning of white adipose tissue (WAT following cold exposure or β3-agonist treatment. Depletion of SIRT6 expression in brown adipocytes reduces expression of thermogenic genes, causing a reduction in cellular respiration. Conversely, SIRT6 overexpression in primary fat cells stimulates the thermogenic program. Mechanistically, SIRT6 interacts with and promotes phospho-ATF2 binding to the PGC-1α gene promoter to activate its expression. The present study reveals a critical role for SIRT6 in regulating thermogenesis of fat.

  1. PELOLOSAN IKAN KURISI (Nemipterus japonicus MELALUI JUVENILE AND TRASH EXLUDER DEVICES PADA JARING ARAD

    Directory of Open Access Journals (Sweden)

    Hufiadi Hufiadi

    2016-06-01

    Full Text Available Permasalahan utama pada perikanan jaring arad adalah banyaknya jumlah hasil tangkap sampingan berukuran kecil yang belum layak tangkap. Dalam upaya untuk mengurangi tangkapan ikan muda yang belum layak tangkap telah dilakukan observasi dan ujicoba operasi penangkapan melalui penggunaan perangkat juvenile and trash exluder devices pada alat tangkap jaring arad yang dioperasikan nelayan di Pekalongan. Perangkat juvenile and trash exluder devices yang digunakan dibedakan pada ukuran jarak antar kisi, yaitu 10,0; 17,5; dan 25,4 mm. Analisis selektivitas kisi menggunakan model kurva logistik dengan bantuan solver pada Microsoft Excel. Hasil penelitian menunjukkan bahwa penggunaan juvenile and trash exluder devices pada jaring arad dapat meloloskan ikan kurisi (Nemipterus spp. berukuran kecil. Ukuran jarak antar kisi 25,4 mm mempunyai selektivitas yang paling baik terhadap ikan kurisi berdasarkan atas ukuran panjang baku dan jarak antar kisi 17,5 mm mempunyai selektivitas paling baik berdasarkan atas ukuran lingkar tubuh ikan kurisi.   The serius problem on bottom mini trawl has the large number caught of bycatch caught especially for juvenile and trash fish. Improvement to reduce catches of juvenile was conducted through observation and experimental fishing using juvenile and trash exluder devices of mini bottom trawl in Pekalongan. The juvenile and trash excluder devices (juvenile and trash exluder devices in the experimental fishing with different space bar of the juvenile and trash exluder devices i.e. 10.0; 17.5; and 25.4 mm. The selectivity analysis of logistic curve by using solver on Microsoft Excel was applied. The results showed that juvenile and trash excluder devices might reduce catches of threadfin breams juvenile. Where as 25.4 space bar had the best selectivity based on the size of threadfin breams fork length and 17.5 mm space bar had the best selectivity based on the size of threadfin breams body girth.

  2. SERUM ACETYLCHOLINESTERASE LEVEL IN THE PATIENTS OF OPIOID (BROWN SUGAR) DEPENDENCE

    OpenAIRE

    Shah, Nilesh; Dave, Kirti

    1992-01-01

    The authors compared the serum acetylcholinesterase level in the patients of brown sugar dependence and the normal volunteers. Significantly lower level of serum acetylcholinesterase was found in patients of brown sugar dependence.

  3. Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

    Science.gov (United States)

    Douris, Nicholas; Stevanovic, Darko M; Fisher, Ffolliott M; Cisu, Theodore I; Chee, Melissa J; Nguyen, Ngoc L; Zarebidaki, Eleen; Adams, Andrew C; Kharitonenkov, Alexei; Flier, Jeffrey S; Bartness, Timothy J; Maratos-Flier, Eleftheria

    2015-07-01

    Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction between FGF21 and the adipocyte, browning is typically associated with activation of the sympathetic nervous system through cold exposure. We tested the hypothesis that FGF21 can act via the brain, to increase sympathetic activity and induce browning, independent of cell-autonomous actions. We administered FGF21 into the central nervous system via lateral ventricle infusion into male mice and found that the central treatment increased norepinephrine turnover in target tissues that include the inguinal white adipose tissue and brown adipose tissue. Central FGF21 stimulated browning as assessed by histology, expression of uncoupling protein 1, and the induction of gene expression associated with browning. These effects were markedly attenuated when mice were treated with a β-blocker. Additionally, neither centrally nor peripherally administered FGF21 initiated browning in mice lacking β-adrenoceptors, demonstrating that an intact adrenergic system is necessary for FGF21 action. These data indicate that FGF21 can signal in the brain to activate the sympathetic nervous system and induce adipose tissue thermogenesis.

  4. Speciation and Localization of Arsenic in White and Brown Rice Grains

    Energy Technology Data Exchange (ETDEWEB)

    Meharg, Andrew A.; Lombi, Enzo; Williams, Paul N.; Scheckel, Kirk G.; Feldmann, Joerg; Raab, Andrea; Zhu, Yongguan; Islam, Rafiql (EPA); (Bangladesh); (UCopenhagen); (Aberdeen); (Chinese Aca. Sci.)

    2008-06-30

    Synchrotron-based X-ray fluorescence (S-XRF) was utilized to locate arsenic (As) in polished (white) and unpolished (brown) rice grains from the United States, China, and Bangladesh. In white rice As was generally dispersed throughout the grain, the bulk of which constitutes the endosperm. In brown rice As was found to be preferentially localized at the surface, in the region corresponding to the pericarp and aleurone layer. Copper, iron, manganese, and zinc localization followed that of arsenic in brown rice, while the location for cadmium and nickel was distinctly different, showing relatively even distribution throughout the endosperm. The localization of As in the outer grain of brown rice was confirmed by laser ablation ICP?MS. Arsenic speciation of all grains using spatially resolved X-ray absorption near edge structure (?-XANES) and bulk extraction followed by anion exchange HPLC?ICP?MS revealed the presence of mainly inorganic As and dimethylarsinic acid (DMA). However, the two techniques indicated different proportions of inorganic:organic As species. A wider survey of whole grain speciation of white (n = 39) and brown (n = 45) rice samples from numerous sources (field collected, supermarket survey, and pot trials) showed that brown rice had a higher proportion of inorganic arsenic present than white rice. Furthermore, the percentage of DMA present in the grain increased along with total grain arsenic.

  5. Browning of Subcutaneous White Adipose Tissue in Humans

    OpenAIRE

    Sidossis, Labros S.; Porter, Craig; Saraf, Manish K.; Børsheim, Elisabet; Radhakrishnan, Ravi S.; Chao, Tony; Ali, Arham; Chondronikola, Maria; Mlcak, Ronald; Finnerty, Celeste C.; Hawkins, Hal K.; Toliver-Kinsky, Tracy; Herndon, David N.

    2015-01-01

    Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT w...

  6. Juvenile sucker cohort tracking data summary and assessment of monitoring program, 2015

    Science.gov (United States)

    Burdick, Summer M.; Ostberg, Carl O.; Hereford, Mark E.; Hoy, Marshal S.

    2016-09-22

    Populations of federally endangered Lost River (Deltistes luxatus) and shortnose suckers (Chasmistes brevirostris) in Upper Klamath Lake, Oregon, are experiencing long-term declines in abundance. Upper Klamath Lake populations are decreasing because adult mortality, which is relatively low, is not being balanced by recruitment of young adult suckers into known adult spawning aggregations. Previous sampling for juvenile suckers indicated that most juvenile sucker mortality in Upper Klamath Lake likely occurs within the first year of life. The importance of juvenile sucker mortality to the dynamics of Clear Lake Reservoir populations is less clear, and factors other than juvenile mortality (such as access to spawning habitat) play a substantial role. For example, production of age-0 juvenile suckers, as determined by fin ray annuli and fin development, has not been detected since 2013 in Clear Lake Reservoir, whereas it is detected annually in Upper Klamath Lake.

  7. Broad-scale patterns of Brook Trout responses to introduced Brown Trout in New York

    Science.gov (United States)

    McKenna, James E.; Slattery, Michael T.; Kean M. Clifford,

    2013-01-01

    Brook Trout Salvelinus fontinalis and Brown Trout Salmo trutta are valuable sport fish that coexist in many parts of the world due to stocking introductions. Causes for the decline of Brook Trout within their native range are not clear but include competition with Brown Trout, habitat alteration, and repetitive stocking practices. New York State contains a large portion of the Brook Trout's native range, where both species are maintained by stocking and other management actions. We used artificial neural network models, regression, principal components analysis, and simulation to evaluate the effects of Brown Trout, environmental conditions, and stocking on the distribution of Brook Trout in the center of their native range. We found evidence for the decline of Brook Trout in the presence of Brown Trout across many watersheds; 22% of sampled reaches where both species were expected to occur contained only Brown Trout. However, a model of the direct relationship between Brook Trout and Brown Trout abundance explained less than 1% of data variation. Ordination showed extensive overlap of Brook Trout and Brown Trout habitat conditions, with only small components of the hypervolume (multidimensional space) being distinctive. Subsequent analysis indicated higher abundances of Brook Trout in highly forested areas, while Brown Trout were more abundant in areas with relatively high proportions of agriculture. Simulation results indicated that direct interactions and habitat conditions were relatively minor factors compared with the effects of repeated stocking of Brown Trout into Brook Trout habitat. Intensive annual stocking of Brown Trout could eliminate resident Brook Trout in less than a decade. Ecological differences, harvest behavior, and other habitat changes can exacerbate Brook Trout losses. Custom stocking scenarios with Brown Trout introductions at relatively low proportions of resident Brook Trout populations may be able to sustain healthy populations of both

  8. Plume trajectory validation study: Brown cloud support project overview

    International Nuclear Information System (INIS)

    Brown-Strattan, M.A.; Smith, M.L.

    1991-01-01

    The brown cloud is an air pollution phenomenon of great concern to the Denver metropolitan area. Regulatory agencies, academia, and research organizations are involved in characterizing the development and transport of the brown cloud and identifying mitigation approaches. In support of this effort, NOAA conducted releases of small (one cubic meter) constant density balloons from sites in Denver and along the South Platte Valley. These balloons, called ''tetroons'' because of their tetrahedral shape, carried five-ounce transponders and were tracked by radar as they rose to predetermined altitudes and followed airflow patterns at those altitudes. The data gathered from these releases included the geographic position and altitude of each tetroon over time. These data will aid efforts to understand brown cloud development, structure, and transport

  9. Group Work with Juvenile Delinquents.

    Science.gov (United States)

    Zimpfer, David G.

    1992-01-01

    Reviews group work literature on juvenile delinquents. Presents overview of interventions, including positive peer culture, cognitive-behavioral treatment, psychoeducational treatment, treatment of learned behavior, action-oriented treatment, milieu therapy, parental involvement, assertiveness training, and music therapy. Discusses outcome…

  10. Do benthic sediment characteristics explain the distribution of juveniles of the deposit-feeding sea cucumber Australostichopus mollis?

    Science.gov (United States)

    Slater, Matthew J.; Jeffs, Andrew G.

    2010-10-01

    Despite the economic importance of many deposit-feeding sea cucumbers, the ecology of their juveniles is poorly understood and factors influencing juvenile habitat selection remain largely unexplained. We investigated the importance of the characteristics of the available sediment in determining the highly localised distribution of juveniles of the deposit-feeding Australasian sea cucumber Australostichopus mollis. Wild-caught juveniles were displaced to non-juvenile habitats with surface sediments characterised by lower total organic content (TOM) and nitrogen content, higher chlorophyll- a content and coarser grain size profiles compared to juvenile sites. The growth of displaced individual animals was monitored over 9 months and compared to control animals caged in the juvenile habitats. Displaced juvenile sea cucumbers had high survival rates that did not differ significantly from juvenile habitats. Displaced juveniles exhibited significantly higher specific growth rate (SGR) than those at juvenile sites ( p < 0.001), although the growth of individuals was highly variable within individual cages and among sites. The lower TOM and nitrogen content, and coarser grain size profiles at non-juvenile sites did not result in reductions in juvenile survival or growth. Higher microphytobenthic activity may have resulted in the higher growth rates observed at shallow non-juvenile sites. The SGR of juveniles over the first 6 months of the experiment ranged between 0.45% d - 1 and 0.74% d - 1 for all sites. This was followed by marked growth limitation between 6 and 9 months either as a result of increasing juvenile biomass in cages or seasonal growth limitation. A subsequent reduction in juvenile density resulted in markedly increased growth over the following 3 month period. Juvenile A. mollis show an ability to exploit a variety of benthic sediment food sources, indicating that their highly localised distribution is not due to differences in the food quality of

  11. Brown tumor mimicking maxillary sinus mucocele as the first manifestation of primary hyperparathyroidism

    DEFF Research Database (Denmark)

    Guldfred, Liviu-Adelin; Daugaard, Søren; von Buchwald, Christian

    2012-01-01

    We describe the first case of brown tumor mimicking a maxillary sinus mucocele as the first manifestation of the patient's primary hyperparathyroidism. A 34-year old woman presented with a 14 days history of elevation of the right orbit, retrobulbar pain and cheek anesthesia. The CT and MR evalua...... either giant cell granuloma or brown tumor. The finding of hyperparathyroidism confirmed the diagnosis of brown tumor. To our knowledge, this is the first report of cystic brown tumor mimicking a mucocele of the maxillary sinus....

  12. Sonographic diagnosis of juvenile polyps in children.

    Science.gov (United States)

    Zhang, Yao; Li, Shi-Xing; Xie, Li-Mei; Shi, Bo; Ju, Hao; Bai, Yu-Zuo; Zhang, Shu-Cheng

    2012-09-01

    The aim of this study was to assess the diagnostic value of ultrasonography for juvenile polyps in children and their sonographic characteristics. A retrospective analysis was performed of the ultrasound findings in 27 children who were diagnosed preoperatively with juvenile polyp within the intestinal tract by ultrasonography and then confirmed by colonoscopy, laparotomy and histopathology. The ultrasonic finding common to all polyps was an isolated intraluminal nodular or massive protrusion, associated with multiple mesh-like fluid areas of different sizes. In 25 children, surrounding pedicle-like low echoes of varying lengths were seen connecting with the polyps to form "mushroom" sign. The color Doppler showed abundant blood flow signals within all polyps and pedicles in a shape of a branch or an umbrella. For seven children with an intussusception, the polyp shadow was detected in the cervical part or interior of the intussusception. Ultrasonography is, thus, considered to be a feasible method for diagnosing intestinal juvenile polyp. Copyright © 2012 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  13. Connecting Young Brown Dwarfs and Directly Imaged Gas-Giant Planets

    Science.gov (United States)

    Liu, Michael; Dupuy, Trent; Allers, Katelyn; Aller, Kimberly; Best, William; Magnier, Eugene

    2015-12-01

    Direct detections of gas-giant exoplanets and discoveries of young (~10-100 Myr) field brown dwarfs from all-sky surveys are strengthening the link between the exoplanet and brown dwarf populations, given the overlapping ages, masses, temperatures, and surface gravities. In light of the relatively small number of directly imaged planets and the modest associated datasets, the large census of young field brown dwarfsprovides a compelling laboratory for enriching our understanding of both classes of objects. However, work to date on young field objects has typically focused on individual discoveries.We present a large comprehensive study of the youngest field brown dwarfs, comprising both previously known objects and our new discoveries from the latest wide-field surveys (Pan-STARRS-1 and WISE). With masses now extending down to ~5 Jupiter masses, these objects have physical properties that largely overlap young gas-giant planets and thus are promising analogs for studying exoplanet atmospheres at unparalleled S/N, spectral resolution, and wavelength coverage. We combine high-quality spectra and parallaxes to determine spectral energy distributions, luminosities, temperatures, and ages for young field objects. We demonstrate that this population spans a continuum in the color-magnitude diagram, thereby forming a bridge between the hot and cool extremes of directly imaged planets. We find that the extremely dusty properties of the planets around 2MASS J1207-39 and HR 8799 do occur in some young brown dwarfs, but these properties do not have a simple correspondence with age, perhaps contrary to expectations. We find young field brown dwarfs can have unusually low temperatures and suggest a new spectral type-temperature scale appropriate for directly imaged planets.To help provide a reference for extreme-contrast imaging surveys, we establish a grid of spectral standards and benchmarks, based on membership in nearby young moving groups, in order to calibrate gravity

  14. Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists

    Science.gov (United States)

    Remick, Amera K.; Catlin, Natasha R.; Quist, Erin M.; Steinbach, Thomas J.; Dixon, Darlene

    2015-01-01

    The Society of Toxicologic Pathology (STP) Education Committee and the STP Reproductive Special Interest Group held a North Carolina regional meeting entitled, “Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists” on March 13, 2015, at the National Institute of Environmental Health Sciences/National Toxicology Program in Research Triangle Park, North Carolina. The purpose of this regional meeting was to familiarize attendees with the topic of juvenile toxicity testing and discuss its relevance to clinical pediatric medicine, regulatory perspectives, challenges of appropriate study design confronted by toxicologists, and challenges of histopathologic examination and interpretation of juvenile tissues faced by pathologists. The 1-day meeting was a success with over 60 attendees representing industry, government, research organizations, and academia. PMID:26220944

  15. Utilization of brown coal in FRG power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kotler, V.R.

    1985-07-01

    FRG methods are studied for utilizing brown coal in view of the development of Kansk-Achinsk brown coal deposits. The use of brown coal in FRG power plants has increased from 15% in 1950- 1960 to 85% (total output) in 1982, providing 79.4 TWh of electrical energy. The remainder was used for briquetting, pulverization and breeze coke. In 1982 nearly 100 million tons of brown coal were burned by six large power stations (rated capacity 11,400 MW) to produce nearly 80 billion kWh of energy. Measures are discussed taken to reduce slagging and to remove excessive moisture content. Problems are analyzed associated with increased contamination of the atmosphere in areas with high population density (412/km/sup 2/) and cost of suppression is reviewed. According to available data, the cost of preventive measures taken by FRG, USA, Japan and the Netherlands is equal to 30% of the total cost of the energy. The most critical problem is suppression of sulfur dioxide, either by dry or wet scrubbers or by the addition of dry dolomite or lime to the furnace (75% of all SO/sub 2/ emissions in FRG comes from power stations). A method is described developed by RWE based on a series of distribution headers in the upper part of combustion chambers. At best, 70-80% reduction can be achieved. 14 references.

  16. Clinical presentation of juvenile Huntington disease

    Directory of Open Access Journals (Sweden)

    Ruocco Heloísa H.

    2006-01-01

    Full Text Available OBJECTIVE: To describe the clinical presentation a group of patients with juvenile onset of Huntington disease. METHOD: All patients were interviewed following a structured clinical questioner. Patients were genotyped for the trinucleotide cytosine-adenine-guanine (CAG repeat in the Huntington Disease gene. High resolution brain MRI was performed in all patients. RESULTS: We identified 4 patients with juvenile onset of disease among 50 patients with Huntington disease followed prospectively in our Neurogenetics clinic. Age at onset varied from 3 to 13 years, there were 2 boys, and 3 patients had a paternal inheritance of the disease. Expanded Huntington disease allele sizes varied from 41 to 69 trinucleotide repeats. The early onset patients presented with rigidity, bradykinesia, dystonia, dysarthria, seizures and ataxia. MRI showed severe volume loss of caudate and putamen nuclei (p=0.001 and reduced cerebral and cerebellum volumes (p=0.01. CONCLUSION: 8% of Huntington disease patients seen in our clinic had juvenile onset of the disease. They did not present with typical chorea as seen in adult onset Huntington disease. There was a predominance of rigidity and bradykinesia. Two other important clinical features were seizures and ataxia, which related with the imaging findings of early cortical atrophy and cerebellum volume loss.

  17. Playing with Father: Anthony Browne's Picture Books and the Masculine.

    Science.gov (United States)

    Bradford, Clare

    1998-01-01

    Concentrates on the father figures in Anthony Browne's books and on the ways in which gender ideologies are encoded in works dealing with family relationships, concentrating on "Zoo" and "The Big Baby," but also looking at "Gorilla" and "Piggybook." Finds that the diversity of Browne's work provides children…

  18. Clozapine modifies the differentiation program of human adipocytes inducing browning.

    Science.gov (United States)

    Kristóf, E; Doan-Xuan, Q-M; Sárvári, A K; Klusóczki, Á; Fischer-Posovszky, P; Wabitsch, M; Bacso, Z; Bai, P; Balajthy, Z; Fésüs, L

    2016-11-29

    Administration of second-generation antipsychotic drugs (SGAs) often leads to weight gain and consequent cardio-metabolic side effects. We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA than in the untreated white adipocytes. Laser scanning cytometry showed that up to 40% of the differentiating single primary and Simpson-Golabi-Behmel syndrome (SGBS) adipocytes had the characteristic morphological features of browning cells. Furthermore, clozapine significantly upregulated ELOVL3, CIDEA, CYC1, PGC1A and TBX1 genes but not ZIC1 suggesting induction of the beige-like and not the classical brown phenotype. When we tested whether browning induced by clozapine can be explained by its known pharmacological effect of antagonizing serotonin (5HT) receptors, it was found that browning cells expressed 5HT receptors 2A, 1D, 7 and the upregulation of browning markers was diminished in the presence of exogenous 5HT. Undifferentiated progenitors or completely differentiated beige or white adipocytes did not respond to clozapine administration. The clozapine-induced beige cells displayed increased basal and oligomycin-inhibited (proton leak) oxygen consumption, but these cells showed a lower response to cAMP stimulus as compared with control beige adipocytes indicating that they are less capable to respond to natural thermogenic anti-obesity cues. Our data altogether suggest that novel pharmacological stimulation of these masked beige adipocytes can be a future therapeutic target for the treatment of SGA-induced weight gain.

  19. Effect of hydrothermal dewatering on the slurryability of brown coals

    International Nuclear Information System (INIS)

    Yu Yujie; Liu Jianzhong; Wang Ruikun; Zhou Junhu; Cen Kefa

    2012-01-01

    Highlights: ► Brown coals are upgraded by hydrothermal dewatering. ► The moisture content and oxygen functional groups decrease during the process. ► The point of zero charge and the contact angle rise as the temperature increases. ► The products were highly hydrophobic. ► The improvement on slurryability of solid products were examined. - Abstract: Two brown coals from China were dewatered under hydrothermal dewatering (HTD) conditions at 250–320 °C for 1 h in a 2 L autoclave. The hydrothermally dewatered products were used to prepare coal water slurry (CWS) with a lower viscosity than brown raw coal slurry. Moreover, the coal rank and heat value of the brown coal increased as the inherent moisture and oxygen content decreased during the HTD process. The maximum solid concentration of CWS prepared from XiMeng coal increased from 45.7% to 59.3%, whereas that of CWS prepared from BaoTou coal increased from 53.7% to 62.1%, after being dewatered at 320 °C. The improvement in the slurryability of brown coal significantly depended on the final temperature of the HTD process, the mechanism of which can be explained by the chemical analysis of oxygen functional groups, zeta potential, and the contact angle of the surface between coal and water. The oxygen functional groups, the oxygen/carbon ratio and hydrogen/carbon ratio in brown coal decreased, indicating that the coal rank was upgraded during the HTD process. As a result, both the point of zero charge and the contact angle increased, implying that the HTD products were highly hydrophobic.

  20. The feeding habits of brown hyaenas ( Hyaena brunnea ) on a game ...

    African Journals Online (AJOL)

    The feeding habits of brown hyaenas ( Hyaena brunnea ) on a game ranch in Limpopo Province, South Africa. ... brown hyaena Hyaena brunnea scats from a game ranch in the Limpopo Province, South Africa. ... AJOL African Journals Online.

  1. Effects of Juvenile Court Exposure on Crime in Young Adulthood

    Science.gov (United States)

    Petitclerc, Amelie; Gatti, Uberto; Vitaro, Frank; Tremblay, Richard E.

    2013-01-01

    Background: The juvenile justice system's interventions are expected to help reduce recidivism. However, previous studies suggest that official processing in juvenile court fails to reduce adolescents' criminal behavior in the following year. Longer term effects have not yet been investigated with a rigorous method. This study used propensity…

  2. 78 FR 17184 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2013-03-20

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1620] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  3. 75 FR 53958 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2010-09-02

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1529] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  4. 78 FR 58288 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2013-09-23

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1634] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  5. 78 FR 65297 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2013-10-31

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1637] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  6. 78 FR 38014 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2013-06-25

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1625] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  7. 75 FR 70216 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2010-11-17

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1533] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  8. 77 FR 24687 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2012-04-25

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1587] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  9. 77 FR 3453 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2012-01-24

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1581] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  10. 77 FR 70994 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2012-11-28

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1510] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  11. 76 FR 26280 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2011-05-06

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1549] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  12. 76 FR 61672 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2011-10-05

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1570] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  13. 76 FR 39075 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2011-07-05

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1562] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  14. 75 FR 16177 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2010-03-31

    ... DEPARTMENT OF JUSTICE Coordinating Council on Juvenile Justice and Delinquency Prevention [OJP (OJJDP) Docket No. 1514] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of...

  15. 77 FR 50486 - Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention

    Science.gov (United States)

    2012-08-21

    ... COORDINATING COUNCIL ON JUVENILE JUSTICE AND DELINQUENCY PREVENTION [OJP (OJJDP) Docket No. 1601] Meeting of the Coordinating Council on Juvenile Justice and Delinquency Prevention AGENCY: Coordinating Council on Juvenile Justice and Delinquency Prevention. ACTION: Notice of meeting. SUMMARY: The...

  16. Juvenile hyperthyroidism: an experience.

    Science.gov (United States)

    Bhadada, S; Bhansali, A; Velayutham, P; Masoodi, S R

    2006-04-01

    To analyze the clinical profile of juvenile hyperthyroidism at presentation, their treatment outcome; predictors of remission and relapse. Retrospective analysis of medical records of 56 patients with juvenile hyperthyroidism seen over a period of 16 years. A cohort of 38 females and 18 males with mean (+/-SD) age of 14.9 +/- 3.4 years (range 3 to 18 years) was analyzed. Majority of patients was in the age group of 12-16 years. Common symptoms observed at presentation were weight loss (82.1%), excessive sweating (78.6%), heat intolerance (76.8%), increased appetite (73.2%) and diarrhea in 48.2%. In addition, accelerated linear growth was observed in 7.1% of patients. Goiter was present in 98.2% of children; 94.5% of which was diffuse and 4.8% was multinodular. The mean ((+/-SD) T3 was 4.8 +/- 3.4 ng/mL (N, 0.6-1.6), T4 was 218 +/- 98 ng/mL (N, 60-155) and TSH was 0.44 +/- 0.36 (N, 0.5-5.5 microIU/mL). TMA positivity seen in 36.9% of patients. All patients were treated with carbimazole; subsequently 4 patients required thyroidectomy and one required radioactive iodine ablation. Mean (+/-SD) duration of follow-up in our patients was 4.9 +/- 3 years, ranging between 1.6 to 16 years and mean (+/-SD) duration of treatment was 34.4 +/- 22.6 months (range 12 to 120 months). Mean (+/-SD) duration to achieve euthyroidism was 5.2 +/- 4.7 months, ranging between 1-33 months. On intention to treat analysis, remission with carbimazole was achieved in 47.6%, remaining patients failed to achieve remission with drug treatment. Graves disease is the commonest cause of juvenile hyperthyroidism. Carbimazole is safe, effective, cheap, and easily available form of therapy. It is occasionally associated with serious side effects but requires prolonged follow up.

  17. Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies.

    Science.gov (United States)

    Meemon, Krai; Sobhon, Prasert

    2015-08-01

    Fasciolosis, caused by Fasciola hepatica and Fasciola gigantica, is one of the most neglected tropical zoonotic diseases. One sustainable control strategy against these infections is the employment of vaccines that target proteins essential for parasites' invasion and nutrition acquiring processes. Cathepsin proteases are the most abundantly expressed proteins in Fasciola spp. that have been tested successfully as vaccines against fasciolosis in experimental as well as large animals because of their important roles in digestion of nutrients, invasion, and migration. Specifically, juvenile-specific cathepsin proteases are the more effective vaccines because they could block the invasion and migration of juvenile parasites whose immune evasion mechanism has not yet been fully developed. Moreover, because of high sequence similarity and identity of cathepsins from juveniles with those of adults, the vaccines can attack both the juvenile and adult stages. In this article, the characteristics and vaccine potentials of juvenile-specific cathepsins, i.e., cathepsins L and B, of Fasciola spp. were reviewed.

  18. [Domestic violence, parenting styles and well-being of German and Turkish juveniles].

    Science.gov (United States)

    Uslucan, Haci-Halil

    2009-01-01

    This intercultural comparative study tries to identify the influences of domestic violence and parenting styles on juvenile violence and the well-being of juveniles. To this end, 304 German and 214 Turkish pupils in Berlin at the age of 13 to 16 completed a standardised questionnaire in their schools. The results show that Turkish juveniles report more harsh parenting styles than their German age-mates, but by controlling statistically the educational background of the parents, these differences disappear. Nevertheless, as a stable finding, we can hold that Turkish parents demand from their children a more cultural appropriate and disciplined behaviour. Furthermore, regarding the rates of juvenile violence, the main differences are seen in violence-legitimating attitudes and witnessing parental violence in the Turkish group. Lastly, in the relations between parenting styles and violence, there seems to be no culturally different patterns, but more differences in the intensity of disadvantaging consequences of punishing and harsh parenting on the well-being of juveniles.

  19. The Delinquencies of Juvenile Law: A Natural Law Analysis

    Directory of Open Access Journals (Sweden)

    Ellis Washington

    2010-07-01

    Full Text Available This article is a substantive analysis tracing the legal, philosophical, social, historical, jurisprudence and political backgrounds of juvenile law, which is an outgrowth of the so-calledProgressive movement - a popular social and political movement of the late nineteenth and early twentieth century. I also trace how this socio-political cause célèbre became a fixture in Americanculture and society due to existential child labor abuses which progressive intellectuals used as a pretext to codify juvenile law in federal law and in statutory law in all 50 states by 1925. Moreover the dubious social science and Machiavellian political efforts that created the juvenile justice system out of whole cloth has done much more harm to the Constitution and to the children it was mandated to protect than any of the Progressive ideas initially envisioned rooted in Positive Law (separation of law and morals. Finally, I present am impassioned argument for congressional repeal of all juvenile case law and statutes because they are rooted in Positive Law, contrary to Natural Law (integration of law and morals, the original intent of the constitutional Framers and are therefore patently unconstitutional.

  20. Genomic evidence of geographically widespread effect of gene flow from polar bears into brown bears.

    Science.gov (United States)

    Cahill, James A; Stirling, Ian; Kistler, Logan; Salamzade, Rauf; Ersmark, Erik; Fulton, Tara L; Stiller, Mathias; Green, Richard E; Shapiro, Beth

    2015-03-01

    Polar bears are an arctic, marine adapted species that is closely related to brown bears. Genome analyses have shown that polar bears are distinct and genetically homogeneous in comparison to brown bears. However, these analyses have also revealed a remarkable episode of polar bear gene flow into the population of brown bears that colonized the Admiralty, Baranof and Chichagof islands (ABC islands) of Alaska. Here, we present an analysis of data from a large panel of polar bear and brown bear genomes that includes brown bears from the ABC islands, the Alaskan mainland and Europe. Our results provide clear evidence that gene flow between the two species had a geographically wide impact, with polar bear DNA found within the genomes of brown bears living both on the ABC islands and in the Alaskan mainland. Intriguingly, while brown bear genomes contain up to 8.8% polar bear ancestry, polar bear genomes appear to be devoid of brown bear ancestry, suggesting the presence of a barrier to gene flow in that direction. © 2014 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd.

  1. Analysis of the Juvenile Idiopathic Arthritis Immunization Schedule

    Directory of Open Access Journals (Sweden)

    L. S. Namazova-Baranova

    2016-01-01

    Full Text Available Background: The connection between vaccination and autoimmune diseases (and rheumatic pathology in particular is still a subject of discussions. When discussing the possibility of vaccinating rheumatic patients we should take into account the ultra high dangers that infectious diseases pose for such patients, including those that can be prevented by vaccination. We should also take into account the experience of using various vaccine types in rheumatic patients, which illustrates of their high safety profile.Objective: Our aim was to study the immunization schedule in children with juvenile idiopathic arthritis.Methods: The evaluation of vaccine history and other anamnestic data in juvenile idiopathic arthritis patients was based on individual medical records (individual child’s card/preventive vaccination certificate, as well as questionnaires filled by mothers.Results: It has been determined that a significant proportion of children with vaccination schedule deviations are juvenile idiopathic arthritis patients. Almost one in four children with a confirmed rheumatic diagnosis has not been immunized against the major vaccine-preventable diseases. In one non-vaccinated group, there was a case of juvenile arthritis onset after recovering from measles. A small number of patient mothers connects the manifestation of rheumatic diseases with vaccination.Conclusion: Violations of vaccination status in JIA patients require corrections according to the results of clinical studies and the recommendations of international experts.

  2. Organic contaminants in thermal plume resident brown trout

    International Nuclear Information System (INIS)

    Romberg, G.P.; Bourne, S.

    1978-01-01

    A pilot study was conducted to identify possible contaminants accumulated by thermal plume-resident fish in Lake Michigan. Brown trout were maintained in tanks receiving intake and discharge (less than or equal to 21 0 C) water from a power plant and were fed a diet of frozen alewife. Fish were sampled over a period of 127 days in order to estimate uptake rates and equilibrium levels for toxic organic and inorganic materials occurring in Lake Michigan fish and water. Experimental fish and natural samples were analyzed to determine the distribution of contaminants in various tissues and the corresponding pollutant levels in similar size brown trout from Lake Michigan. The quantitative analyses for the major organic contaminants are summarized. Without exception, the pyloric caecum of brown trout contained the highest concentration of lipids, PCB's, and chlorinated pesticides. Gill and kidney samples contained lower concentrations of contaminants than the caecum, while liver and muscle values were lowest

  3. The relationship between family functioning and juvenile delinquency at SMKN 4 Pekanbaru

    Directory of Open Access Journals (Sweden)

    Trio Saputra

    2017-06-01

    Full Text Available This study aims to determine the relationship between family functioning juvenile delinquency. This study used 120 subjects students in SMK N 4 Pekanbaru, research data were collected using two scales, the scale of family function and delinquency with item number 53. Sampling in this study using non probabilitis sampling techniques, data analysis using product moment, with the help of SPSS 17.0 for Windows. Based on the analysis found that there is a negative relationship between family functioning juvenile delinquency, the correlation p = -0.590 0.000. Then the hypothesis is accepted, meaning the lower the higher the family function of juvenile delinquency and conversely the higher the lower a family function of juvenile delinquency

  4. The Importance of Juvenile Root Traits for Crop Yields

    Science.gov (United States)

    White, Philip; Adu, Michael; Broadley, Martin; Brown, Lawrie; Dupuy, Lionel; George, Timothy; Graham, Neil; Hammond, John; Hayden, Rory; Neugebauer, Konrad; Nightingale, Mark; Ramsay, Gavin; Thomas, Catherine; Thompson, Jacqueline; Wishart, Jane; Wright, Gladys

    2014-05-01

    Genetic variation in root system architecture (RSA) is an under-exploited breeding resource. This is partly a consequence of difficulties in the rapid and accurate assessment of subterranean root systems. However, although the characterisation of root systems of large plants in the field are both time-consuming and labour-intensive, high-throughput (HTP) screens of root systems of juvenile plants can be performed in the field, glasshouse or laboratory. It is hypothesised that improving the root systems of juvenile plants can accelerate access to water and essential mineral elements, leading to rapid crop establishment and, consequently, greater yields. This presentation will illustrate how aspects of the juvenile root systems of potato (Solanum tuberosum L.) and oilseed rape (OSR; Brassica napus L.) correlate with crop yields and examine the reasons for such correlations. It will first describe the significant positive relationships between early root system development, phosphorus acquisition, canopy establishment and eventual yield among potato genotypes. It will report the development of a glasshouse assay for root system architecture (RSA) of juvenile potato plants, the correlations between root system architectures measured in the glasshouse and field, and the relationships between aspects of the juvenile root system and crop yields under drought conditions. It will then describe the development of HTP systems for assaying RSA of OSR seedlings, the identification of genetic loci affecting RSA in OSR, the development of mathematical models describing resource acquisition by OSR, and the correlations between root traits recorded in the HTP systems and yields of OSR in the field.

  5. A Structural Equation Modeling Analysis of Influences on Juvenile Delinquency

    Science.gov (United States)

    Barrett, David E.; Katsiyannis, Antonis; Zhang, Dalun; Zhang, Dake

    2014-01-01

    This study examined influences on delinquency and recidivism using structural equation modeling. The sample comprised 199,204 individuals: 99,602 youth whose cases had been processed by the South Carolina Department of Juvenile Justice and a matched control group of 99,602 youth without juvenile records. Structural equation modeling for the…

  6. Role of radiation therapy for 'juvenile' angiofibroma

    Energy Technology Data Exchange (ETDEWEB)

    Gudea, F.; Vega, M.; Canals, E.; Montserrat, J.M.; Valdano, J. (Univ. Autonoma de Barcelona (Spain). Hospital de la Santa Creu i Sant Pau (Spain))

    1990-09-01

    Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm which occurs primarily in male adolescents and is characterized by aggressive local growth. The controversy concerning appropriate treatment for patients with juvenile angiofibroma persists. Radiation therapy and survival resection have both been reported to be effective to control a high proportion of these tumours. The case reported here demonstrates a locally advanced JNA controlled by radiation therapy. (author).

  7. Behandling af juvenile angiofibromer med partikelembolisering og endoskopisk kirurgi

    DEFF Research Database (Denmark)

    Thuesen, Anne Daugaard; Jakobsen, John; Nepper-Rasmussen, Jørgen

    2005-01-01

    INTRODUCTION: Juvenile angiofibroma is a benign, rich vascular nasal tumor, and the biggest complication in surgery is the great loss of blood. Since 1997, Odense University Hospital (OUH) has used preoperative particle embolization and endoscopic surgery to combat this problem. MATERIALS...... and may be considered to be satisfactory. DISCUSSION: Endovascular embolization of juvenile angiofibromas followed by endoscopic surgery is considered to be the preferred treatment method today....

  8. The Challenge and Opportunity of Parental Involvement in Juvenile Justice Services.

    Science.gov (United States)

    Burke, Jeffrey D; Mulvey, Edward P; Schubert, Carol A; Garbin, Sara R

    2014-04-01

    The active involvement of parents - whether as recipients, extenders, or managers of services - during their youth's experience with the juvenile justice system is widely assumed to be crucial. Parents and family advocacy groups note persisting concerns with the degree to which successful parental involvement is achieved. Justice system providers are highly motivated and actively working to make improvements. These coalescing interests provide a strong motivation for innovation and improvement regarding family involvement, but the likely success of these efforts is severely limited by the absence of any detailed definition of parental involvement or validated measure of this construct. Determining whether and how parental involvement works in juvenile justice services depends on the development of clear models and sound measurement. Efforts in other child serving systems offer guidance to achieve this goal. A multidimensional working model developed with parents involved in child protective services is presented as a template for developing a model for parental involvement in juvenile justice. Features of the model requiring changes to make it more adaptable to juvenile justice are identified. A systematic research agenda for developing methods and measures to meet the present demands for enhanced parental involvement in juvenile justice services is presented.

  9. Long-wavelength (red) light produces hyperopia in juvenile and adolescent tree shrews.

    Science.gov (United States)

    Gawne, Timothy J; Ward, Alexander H; Norton, Thomas T

    2017-11-01

    In infant tree shrews, exposure to narrow-band long-wavelength (red) light, that stimulates long-wavelength sensitive cones almost exclusively, slows axial elongation and produces hyperopia. We asked if red light produces hyperopia in juvenile and adolescent animals, ages when plus lenses are ineffective. Animals were raised in fluorescent colony lighting (100-300 lux) until they began 13days of red-light treatment at 11 (n=5, "infant"), 35 (n=5, "juvenile") or 95 (n=5, "adolescent") days of visual experience (DVE). LEDs provided 527-749 lux on the cage floor. To control for the higher red illuminance, a fluorescent control group (n=5) of juvenile (35 DVE) animals was exposed to ∼975 lux. Refractions were measured daily; ocular component dimensions at the start and end of treatment and end of recovery in colony lighting. These groups were compared with normals (n=7). In red light, the refractive state of both juvenile and adolescent animals became significantly (Prefractions (0.6±0.3D) were normal. In red-treated juveniles the vitreous chamber was significantly smaller than normal (Plight-induced slowed growth and hyperopia in juvenile and adolescent tree shrews demonstrates that the emmetropization mechanism is still capable of restraining eye growth at these ages. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Criteria for sustainable fisheries on juveniles illustrated for Mediterranean hake: control the juvenile harvest, and safeguard spawning refugia to rebuild population fecundity

    Directory of Open Access Journals (Sweden)

    John F. Caddy

    2015-09-01

    Full Text Available The paper provides a broad overview of issues relevant to management of fisheries for juvenile fish in contrast to the many stock assessments following Beverton and Holt’s (1957 approach for rational exploitation of mature fishes. A perspective on assessing these fisheries is illustrated for juvenile European hake, Merluccius merluccius, in the northwestern Mediterranean. Here, a constant natural mortality (M assumption is incorrect, as is the assumption that high fecundities are necessarily adequate for stock replacement. The high Ms-at-age for juveniles generated by the reciprocal model are shown to be a logical counterpart to the high fecundity of hake. Charnov’s criterion of intergenerational reproductive replacement is used to test for a sustainable population, analogous to a limit reference point warning of the dangers of overfishing beyond population replacement. Once peak mortality rates of age 2 hake exceed F(2=1.1-1.2, which is currently the case, reproductive replacement may be at risk. Adult exploitation by inshore trawls is low, and maturing hake surviving the fine-mesh trawl fishery migrate offshore with a reduced vulnerability to fine-mesh gears. Early research suggested that rough bottom near the shelf edge once formed a refugium protecting offshore spawners from trawling, and led to abundant recruitment of juveniles nearer shore. It may not do so if offshore fishing effort by reinforced bottom trawls, gill nets and longlines is uncontrolled. Restoring offshore refugia to protect spawners and controlling peak fishing mortality of juveniles would be a precautionary strategy aimed at restoring previous levels of recruitment to the small-mesh trawl fishery.

  11. An unsuccessful search for brown dwarf companions to white dwarf stars

    Science.gov (United States)

    Shipman, Harry L.

    1986-01-01

    The results of a survey to detect excess infrared emission from white dwarf stars which would be attributable to a low mass companion are reviewed. Neither a simple comparison of spectroscopically identified white dwarf stars with the IRAS Point Source Catalog nor the coadding of IRAS survey data resulted in a detection of a brown dwarf. The seven nearest stars where the most stringent limits to the presence of a brown dwarf were obtained are listed, and an effort to detect brown dwarfs in the solar neighborhood is discussed.

  12. [ABOUT JUVENILE NASOPHARYNGEAL ANGIOFIBROMA].

    Science.gov (United States)

    Urbain, V; Meunier, P; Otto, B

    2015-09-01

    We report the case of a young man with a juvenile nasopharyngeal angiofibroma. In this paper, we will first remind the clinical signs of this pathology and its radiological appearance (localisation and extensions). Then we will explain how radioembolisation techniques were used to facilitate the surgical intervention. Finally we will discuss the histology of this tumor.

  13. LC-MS Untargeted Metabolomics To Explain the Signal Metabolites Inducing Browning in Fresh-Cut Lettuce.

    Science.gov (United States)

    García, Carlos J; García-Villalba, Rocío; Gil, María I; Tomas-Barberan, Francisco A

    2017-06-07

    Enzymatic browning is one of the main causes of quality loss in lettuce as a prepared and ready-to-eat cut salad. An untargeted metabolomics approach using UPLC-ESI-QTOF-MS was performed to explain the wound response of lettuce after cutting and to identify the metabolites responsible of browning. Two cultivars of Romaine lettuce with different browning susceptibilities were studied at short time intervals after cutting. From the total 5975 entities obtained from the raw data after alignment, filtration reduced the number of features to 2959, and the statistical analysis found that only 1132 entities were significantly different. Principal component analysis (PCA) clearly showed that these samples grouped according to cultivar and time after cutting. From those, only 15 metabolites belonging to lysophospholipids, oxylipin/jasmonate metabolites, and phenolic compounds were able to explain the browning process. These selected metabolites showed different trends after cutting; some decreased rapidly, others increased but decreased thereafter, whereas others increased during the whole period of storage. In general, the fast-browning cultivar showed a faster wound response and a higher raw intensity of some key metabolites than the slow-browning one. Just after cutting, the fast-browning cultivar contained 11 of the 15 browning-associated metabolites, whereas the slow-browning cultivar only had 5 of them. These metabolites could be used as biomarkers in breeding programs for the selection of lettuce cultivars with lower browning potential for fresh-cut applications.

  14. Síndrome de ativação macrofágica associada com artrite idiopática juvenil sistêmica Macrophage activation syndrome associated with systemic juvenile idiopathic arthritis

    Directory of Open Access Journals (Sweden)

    Clovis Artur A. Silva

    2004-12-01

    Full Text Available OBJETIVO: Descrever as características da síndrome de ativação macrofágica associada a artrite idiopática juvenil. DESCRIÇÃO DOS CASOS: Foram analisados retrospectivamente os prontuários de 462 pacientes com artrite idiopática juvenil. Destes, sete (1,5% pacientes desenvolveram síndrome de ativação macrofágica; todos tinham a forma sistêmica da doença. A mediana de idade de início da artrite idiopática juvenil foi de 3 anos e 10 meses, e a mediana do tempo de duração da artrite idiopática juvenil antes da síndrome de ativação macrofágica foi de 8 anos e 4 meses. Todos os pacientes apresentaram febre, icterícia, hepatoesplenomegalia, sangramentos, pancitopenia e elevação das enzimas hepáticas e dos tempos de coagulação e bilirrubina direta. Três casos apresentaram infecções associadas e um caso desenvolveu a síndrome de ativação macrofágica 2 semanas após a introdução de sulfasalazina. Três pacientes morreram. Proliferação macrofágica e hemofagocitose foram evidenciadas em cinco. A terapêutica da síndrome de ativação macrofágica incluiu pulsoterapia com metilprednisolona em todos, ciclosporina em três, plasmaférese em dois e gamaglobulina endovenosa em dois. COMENTÁRIOS: A síndrome de ativação macrofágica é uma complicação da artrite idiopática juvenil sistêmica com alta morbidade e mortalidade.OBJECTIVE: To describe the characteristics of macrophage activation syndrome associated with juvenile idiopathic arthritis. DESCRIPTION: This is a retrospective study involving 462 patients with juvenile idiopathic arthritis. Seven (1.5% of those patients suffered from systemic onset juvenile idiopathic arthritis and developed macrophage activation syndrome. The median age of the juvenile idiopathic arthritis onset was 3 years and 10 months and the median duration of juvenile idiopathic arthritis before macrophage activation syndrome was 8 years and 4 months. All of them presented with fever

  15. THE POSITION OF JUVENILES IN THE NEW CRIMINAL LAW OF THE REPUBLIC OF SERBIA

    Directory of Open Access Journals (Sweden)

    Dragan Jovašević

    2008-01-01

    Full Text Available The new juvenile (substantive, procedural and executive criminal law came into force at the beginning of 2006 in the Republic of Serbia.. In this way, by concluding its reform of criminal law, the Republic of Serbia followed the trends of modern criminal policies of other developed European countries (France, Germany, and Croatia. Therefore, in that special, specifi c way, it determined the criminal legal status of juveniles. That specifi city is refl ected in various directions : 1 Lex specialis was brought in – a special Act on juvenile perpetrators of criminal acts and the criminal legal protection of juveniles when juveniles in their criminal legal position are completely separate from the status of adults as perpetrators of criminal acts, 2 the special authority of district courts is determined for taking action in criminal cases of juvenile perpetrators of criminal acts, 3 compulsory specialisation is provided for persons in the criminal judiciary taking part in criminal proceedings for juvenile perpetrators of criminal acts ( with previous training and issuing of licences ‘certifi cates’ and 4 besides criminal sanctions, the law has provided for juvenile perpetrators of criminal acts the possibility of sentencing specifi c measures sui generis – educational orders ( directions or recommendations – as means of restorative justice by which the commencement or carrying out of legal action is avoided. This paper precisely deals with this new criminal legal position of juvenile perpetrators of criminal acts and with the new institutions of restorative justice from theoretical, practical and comparative legal aspects.

  16. Cleanup at Browns Ferry 3

    International Nuclear Information System (INIS)

    Mitchell, Brad; Janvrin, R.W.

    1995-01-01

    When major work had to be done in the drywell of Browns Ferry 3, the utility, Tennessee Valley Authority (TVA), decided that it made sense to make it ''street clothes clean'' for workers. This not only made work easier, it saved time and millions of dollars. (author)

  17. Contrasting patterns of changes in abundance following a bleaching event between juvenile and adult scleractinian corals

    Science.gov (United States)

    Álvarez-Noriega, Mariana; Baird, Andrew H.; Bridge, Tom C. L.; Dornelas, Maria; Fontoura, Luisa; Pizarro, Oscar; Precoda, Kristin; Torres-Pulliza, Damaris; Woods, Rachael M.; Zawada, Kyle; Madin, Joshua S.

    2018-06-01

    Coral bleaching events have caused extensive mortality on reefs around the world. Juvenile corals are generally less affected by bleaching than their conspecific adults and therefore have the potential to buffer population declines and seed recovery. Here, we use juvenile and adult abundance data at 20 sites encircling Lizard Island, Great Barrier Reef, before and after the 2016 bleaching event to quantify: (1) correlates of changes in juvenile abundance following a bleaching event; (2) differences in susceptibility to extreme thermal stress between juveniles and adults. Declines in juvenile abundance were lower at sites closer to the 20-m-depth contour and higher for Acropora and Pocillopora juveniles than for other taxa. Juveniles of Acropora and Goniastrea were less susceptible to bleaching than adults, but the opposite was true for Pocillopora spp. and taxa in the family Merulinidae. Our results indicate that the potential of the juvenile life stage to act as a buffer during bleaching events is taxon-dependent.

  18. Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma.

    Science.gov (United States)

    Mishra, A; Pandey, A; Mishra, S C

    2017-09-01

    Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma. Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports. Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated. Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics.

  19. Effects of natal departure and water level on survival of juvenile snail kites (Rostrhamus sociabilis) in Florida

    Science.gov (United States)

    Dreitz, V.J.; Kitchens, W.M.; DeAngelis, D.L.

    2004-01-01

    Survival rate from fledging to breeding, or juvenile survival, is an important source of variation in lifetime reproductive success in birds. Therefore, determining the relationship between juvenile survival and environmental factors is essential to understanding fitness consequences of reproduction in many populations. With increases in density of individuals and depletion of food resources, quality of most habitats deteriorates during the breeding season. Individuals respond by dispersing in search of food resources. Therefore, to understand the influence of environmental factors on juvenile survival, it is also necessary to know how natal dispersal influences survival of juveniles. We examined effects of various environmental factors and natal dispersal behavior on juvenile survival of endangered Snail Kites (Rostrhamus sociabilis) in central and southern Florida, using a generalized estimating equations (GEEs) approach and model selection criteria. Our results suggested yearly effects and an influence of age and monthly minimum hydrologic levels on juvenile Snail Kite survival. Yearly variation in juvenile survival has been reported by other studies, and other reproductive components of Snail Kites also exhibit such variation. Age differences in juvenile survival have also been seen in other species during the juvenile period. Our results demonstrate a positive relationship between water levels and juvenile survival. We suggest that this is not a direct linear relationship, such that higher water means higher juvenile survival. The juvenile period is concurrent with onset of the wet season in the ecosystem we studied, and rainfall increases as juveniles age. For management purposes, we believe that inferences suggesting increasing water levels during the fledging period will increase juvenile survival may have short-term benefits but lead to long-term declines in prey abundance and possibly wetland vegetation structure.

  20. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

    DEFF Research Database (Denmark)

    Emmett, Matthew J.; Lim, Hee-Woong; Jager, Jennifer

    2017-01-01

    Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease1. However, the transcriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before environmental cold...

  1. Delinquency Cases in Juvenile Court, 2002. OJJDP Fact Sheet #02

    Science.gov (United States)

    Stahl, Anne L.

    2006-01-01

    This fact sheet presents statistics on delinquency cases processed by juvenile courts in 2002. The number of delinquency cases handled by juvenile courts decreased 11 percent between 1997 and 2002. During this time, the number of person offense cases decreased 2 percent, property offense cases decreased 27 percent, drug law violation cases…

  2. Apple phenolics and their contribution to enzymatic browning reactions

    Directory of Open Access Journals (Sweden)

    Wiesław Oleszek

    2014-01-01

    Full Text Available Chlorogenic acid, epicatechin, procyanidin B2 and C1 were isolated from apple skin. These compounds as well as quercetine and phloretine glycosides isolated from apples were studied individually and as mixtures for their participation in the enzymatic browning reactions. The importance of quercetine glycosides and the synergistic effect of phloridzin and phloretine xyloglucoside with chlorogenic acid and flavans in the browning reaction are reported.

  3. Applying Roper v. Simmons in juvenile transfer and waiver proceedings: a legal and neuroscientific inquiry.

    Science.gov (United States)

    Fabian, John Matthew

    2011-08-01

    In 2005, the U.S. Supreme Court held the death penalty unconstitutional as applied to juveniles in Roper v. Simmons. The Court reasoned that juveniles were less criminally culpable than adults because they lack maturity, they are more vulnerable to peer influence, and their character is not as well formed as that of adults. Although Roper addressed the imposition of the ultimate punishment of death within the context of a juvenile's moral blameworthiness for a crime of murder, this article considers the application of the Court's reasoning in Roper to the issue of juvenile waiver. Specifically, the author asks the question whether Roper's ultimate language distinguishing juveniles from adults in capital cases should apply to the conventional practice of their trial and sentencing as adults. Despite the fact that juvenile transfer is a less serious sanction than the death penalty, this inquiry confronts the traditional objective of the juvenile court system, a system of punishment that was founded on rehabilitation rather than retribution. The author questions whether the punitive objectives of deterrence and retribution are satisfied by juvenile waiver and whether the mitigating effect of adolescence negates the trial of youth as adults.

  4. Brown tumor of mandible with primary hyperparathyroidism

    International Nuclear Information System (INIS)

    Ali, S.K.; Khan, F.A.; Siddiq, A.; Hanif, M.S.

    2011-01-01

    Parathyroid hormone (PTH) is secreted and released by the parathyroid glands, the activity of which is controlled by the ionized serum calcium level. Increased PTH secretion results in hyperparathyroidism. Hyperparathyroidism is classified as primary, secondary and tertiary types. Primary hyperparathyroidism is characterized by increased parathyroid hormone secretion occurring as a result of abnormality in one or more of the parathyroid glands. Brown tumors are non-neoplastic lesions as a result of abnormal bone metabolism in cases of hyperparathyroidism, creating a local destructive phenomenon. A rare case of a young female patient with brown tumors in her mandible associated with primary hyperparathyroidism, is reported. (author)

  5. Exploring the role of the internet in juvenile prostitution cases coming to the attention of law enforcement.

    Science.gov (United States)

    Wells, Melissa; Mitchell, Kimberly J; Ji, Kai

    2012-01-01

    This exploratory analysis examines the role of the Internet in juvenile prostitution cases coming to the attention of law enforcement. The National Juvenile Prostitution Study (N-JPS) collected information from a national sample of law enforcement agencies about the characteristics of juvenile prostitution cases. In comparison to non-Internet juvenile prostitution cases, Internet juvenile prostitution cases involved younger juveniles and police were more likely to treat juveniles as victims rather than offenders. In addition, these cases were significantly more likely to involve a family or acquaintance exploiter. This analysis suggests that the role of the Internet may impact legal and social service response to juveniles involved in prostitution. In addition, it highlights the need for interventions that acknowledge the vulnerabilities of youth involved in this type of commercial sexual exploitation.

  6. Juvenile Pacific Salmon in Puget Sound

    National Research Council Canada - National Science Library

    Fresh, Kurt L

    2006-01-01

    Puget sound salmon (genus Oncorhynchus) spawn in freshwater and feed, grow and mature in marine waters, During their transition from freshwater to saltwater, juvenile salmon occupy nearshore ecosystems in Puget Sound...

  7. Strengths and Limitations of the Personality Inventory for Youth (PIY in Juvenile Delinquency Assessments

    Directory of Open Access Journals (Sweden)

    Robert A. Semel

    2014-11-01

    Full Text Available This article highlights and discusses the usefulness of the Personality Inventory for Youth (PIY in juvenile delinquency assessments. Psychiatric disorders have high prevalence rates among youths in the juvenile justice system. The PIY was developed to evaluate a broad range of behavioral and psychological characteristics, which may make it useful in juvenile delinquency assessment contexts. Practical and psychometric strengths and limitations of the PIY in the juvenile delinquency assessment context are presented, with reference to relevant research literature. The effectiveness of this instrument in detecting response bias, particularly under-reporting, and for identifying problems associated with delinquency is discussed. The issue of item overlap and spurious influences on scale correlations, especially between the PIY Defensiveness and Delinquency scales, is also addressed. A comparison of findings with the PIY and the Minnesota Multiphasic Personality Inventory–Adolescent (MMPI-A in juvenile justice samples helps to identify broader considerations about how youths in juvenile justice settings respond to self-report psychological inventories. Finally, the author offers some practical considerations for evaluators when using the PIY in juvenile delinquency assessments, and suggestions for future research.

  8. Consortial brown tide - picocyanobacteria blooms in Guantánamo Bay, Cuba.

    Science.gov (United States)

    Hall, Nathan S; Litaker, R Wayne; Kenworthy, W Judson; Vandersea, Mark W; Sunda, William G; Reid, James P; Slone, Daniel H; Butler, Susan

    2018-03-01

    A brown tide bloom of Aureoumbra lagunensis developed in Guantánamo Bay, Cuba during a period of drought in 2013 that followed heavy winds and rainfall from Hurricane Sandy in late October 2012. Based on satellite images and water turbidity measurements, the bloom appeared to initiate in January 2013. The causative species (A. lagunensis) was confirmed by microscopic observation, and pigment and genetic analyses of bloom samples collected on May 28 of that year. During that time, A. lagunensis reached concentrations of 900,000 cells ml -1 (28 ppm by biovolume) in the middle portion of the Bay. Samples could not be collected from the northern (Cuban) half of the Bay because of political considerations. Subsequent sampling of the southern half of the Bay in November 2013, April 2014, and October 2014 showed persistent lower concentrations of A. lagunensis, with dominance shifting to the cyanobacterium Synechococcus (up to 33 ppm in April), an algal group that comprised a minor bloom component on May 28. Thus, unlike the brown tide bloom in Laguna Madre, which lasted 8 years, the bloom in Guantánamo Bay was short-lived, much like recent blooms in the Indian River, Florida. Although hypersaline conditions have been linked to brown tide development in the lagoons of Texas and Florida, observed euhaline conditions in Guantánamo Bay (salinity 35-36) indicate that strong hypersalinity is not a requirement for A. lagunensis bloom formation. Microzooplankton biomass dominated by ciliates was high during the observed peak of the brown tide, and ciliate abundance was high compared to other systems not impacted by brown tide. Preferential grazing by zooplankton on non-brown tide species, as shown in A. lagunensis blooms in Texas and Florida, may have been a factor in the development of the Cuban brown tide bloom. However, subsequent selection of microzooplankton capable of utilizing A. lagunensis as a primary food source may have contributed to the short-lived duration

  9. New solutions in the juvenile criminal law in the light of the restorative justice

    Directory of Open Access Journals (Sweden)

    Jovašević Dragan

    2007-01-01

    Full Text Available New criminal legislation got into force in Serbia at the beginning of 2006. In that way, Serbia got unique Criminal Code which includes all provisions of material criminal law except provisions related to the criminal position of juveniles. System of criminal sanctions for juvenile off enders, procedure for their imposition and the way, procedure and terms for their execution are regulated by the provisions of the separate law - the Law on juvenile off enders and criminal protection of juveniles. Some of the most important novelties introduced by new juvenile criminal law are system of diversion, i.e. system of diversion orders, which aim at excluding the imposition of criminal sanctions in the cases when criminal sanction is not necessary from the perspective of crime suppression. Bearing that in mind, this paper is dedicated to forms of diversion orders as a form of measures that lead to more efficient system of restorative justice within our new juvenile criminal legislation. .

  10. What is Justice for Juveniles?

    Science.gov (United States)

    Rothwell, Jennifer Truran

    1997-01-01

    Provides background information and related learning activities for three areas of inquiry involving youth and violence: (1) "Evolution of the Juvenile Justice System"; (2) "The Literature of Crime and Poverty"; (3) "Youth Crime and Public Policy." Includes a list of six recommended Web sites. (MJP)

  11. Role-Playing (Psychodrama in the Social Rehabilitation of Juveniles

    Directory of Open Access Journals (Sweden)

    Barbara Grzyb

    2015-12-01

    Full Text Available The article discusses the term of psychodrama in the aspect of the social rehabilitation process of juveniles. An important area of considerations is noting the most effective form of work in the modification of socially desirable behavior. Moreover, the identification and wider discussion of the aspect of psychodrama interaction indicates the emotional, therapeutic, and above all correctional dimension, so desired in the social rehabilitation of juveniles.

  12. Demographic Prediction of Juvenile Delinquency across and within Delinquency Levels.

    Science.gov (United States)

    Fink, Michael D.; Truckenmiller, James L.

    Demographic prediction of juvenile delinquency has been hampered by the heterogeniety of youth samples. In an attempt to correct for sampling bias in predicting juvenile delinquency, 1,689 male and female youths(aged 12 to 19, drawn from a 6 percent systematic, census tract, random sample of Pennsylvania school youths) completed the Youth Needs…

  13. Incarcerated Dutch Juvenile Sex Offenders Compared with Non-Sex Offenders

    Science.gov (United States)

    van Wijk, Anton Ph.; Vreugdenhil, Coby; van Horn, Joan; Vermeiren, Robert; Doreleijers, Theo A. H.

    2007-01-01

    There is some debate about whether or not sex offenders are similar to non-sex offenders with regard to family background (parental characteristics), personality, and psychopathology. The central aim of this study focused on the comparison of juvenile sex offenders and non-sex offenders. The sample consisted of incarcerated juvenile male sex (n =…

  14. New developments in juvenile systemic and localized scleroderma.

    Science.gov (United States)

    Foeldvari, Ivan

    2013-11-01

    Juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSS) are both orphan diseases, with jLS around 10 times more frequent than jSS. In recent years the time gap between the appearance of symptoms and diagnosis has become significantly shorter. This review focuses on the new classifications of jSS and jLS, and on the developments and adaptations of the outcome measures for certain organ involvements whereby progress has been made regarding pediatric patients. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Exploration of the brown dwarf regime around solar-like stars by CoRoT

    OpenAIRE

    Csizmadia, Szilárd

    2016-01-01

    Aims. A summary of the CoRoT brown dwarf investigations are presented. Methods. Transiting brown dwarfs around solar like stars were studied by using the photometric time-series of CoRoT, and ground based radial velocity measurements. Results. CoRoT detected three transiting brown dwarfs around F and G dwarf stars. The occurence rate of brown dwarfs was found to be 0.20 +/- 0.15% around solar-like stars which is compatible with the value obtained by Kepler-data.

  16. Juvenile nasopharyngeal angiofibroma: Timisoara ENT Department's experience.

    Science.gov (United States)

    Iovanescu, Gheorghe; Ruja, Steluta; Cotulbea, Stan

    2013-07-01

    Juvenile nasopharyngeal angiofibroma is a histologically benign, but very aggressive and destructive tumor found exclusively in young males. The management of juvenile nasopharyngeal angiofibroma has changed in recent years, but it still continues to be a challenge for the multidisciplinary head and neck surgical team. The purpose of this study was to review a series of 30 patients describing the treatment approach used and studying the outcome of juvenile nasopharyngeal angiofibroma in the ENT Department Timisoara, Romania for a period of 30 years. The patients were diagnosed and treated during the years 1981-2011. All patients were male. Tumors were classified using Radkowski's staging system. Computed tomography and magnetic resonance imaging allowed for accurate diagnosis and staging of the tumors. Biopsies were not performed. Surgery represented the gold standard for treatment of juvenine nasopharyngeal angiofibroma. All patients had the tumor removed by an external approach, endoscopic surgical approach not being employed in this series of patients. All patients were treated surgically. Surgical techniques performed were: Denker-Rouge technique in 13 cases (43.33%), paralateronasal technique in 7 cases (23.33%), retropalatine technique in 5 cases (16.66%) and transpalatine technique in 5 cases (16.66%). No preoperative tumor embolization was performed. The recurrence rate was 16.66%. The follow-up period ranged from 1 year to 12 years. Management of juvenile nasopharyngeal angiofibroma remains a surgical challenge. Clinical evaluation and surgical experience are very important in selecting the proper approach. A multidisciplinary team, with an experienced surgeon and good collaboration with the anesthesiologist are needed for successful surgical treatment. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  17. Enzymatic oxalic acid regulation correlated with wood degradation in four brown-rot fungi

    Science.gov (United States)

    Anne Christine Steenkjær Hastrup; Frederick Green III; Patricia K. Lebow; Bo Jensen

    2012-01-01

    Oxalic acid is a key component in the initiation of brown-rot decay and it has been suggested that it plays multiple roles during the degradation process. Oxalic acid is accumulated to varying degrees among brown-rot fungi; however, details on active regulation are scarce. The accumulation of oxalic acid was measured in this study from wood degraded by the four brown-...

  18. Role of ascorbic acid in the inhibition of polyphenol oxidase and the prevention of browning in different browning-sensitive Lactuca sativa var. capitata (L.) and Eruca sativa (Mill.) stored as fresh-cut produce.

    Science.gov (United States)

    Landi, Marco; Degl'Innocenti, Elena; Guglielminetti, Lorenzo; Guidi, Lucia

    2013-06-01

    Polyphenol oxidase (PPO) and, to a minor extent, peroxidase (POD) represent the key enzymes involved in enzymatic browning, a negative process induced by cutting fresh-cut produce such as lettuce (Lactuca sativa) and rocket salad (Eruca sativa). Although ascorbic acid is frequently utilised as an anti-browning agent, its mechanism in the prevention of the browning phenomenon is not clearly understood. The activity of PPO and POD and their isoforms in lettuce (a high-browning and low-ascorbic acid species) and rocket salad (a low-browning and high-ascorbic species) was characterised. The kinetic parameters of PPO and in vitro ascorbic acid-PPO inhibition were also investigated. In rocket salad, PPO activity was much lower than that in lettuce and cutting induced an increase in PPO activity only in lettuce. Exogenous ascorbic acid (5 mmol L(-1)) reduced PPO activity by about 90% in lettuce. POD did not appear to be closely related to browning in lettuce. PPO is the main enzyme involved in the browning phenomenon; POD appears to play a minor role. The concentration of endogenous ascorbic acid in rocket salad was related to its low-browning sensitivity after cutting. In lettuce, the addition of ascorbic acid directly inhibited PPO activity. The results suggest that the high ascorbic acid content found in rocket salad plays an effective role in reducing PPO activity. © 2012 Society of Chemical Industry.

  19. Arctic Tundra Greening and Browning at Circumpolar and Regional Scales

    Science.gov (United States)

    Epstein, H. E.; Bhatt, U. S.; Walker, D. A.; Raynolds, M. K.; Yang, X.

    2017-12-01

    Remote sensing data have historically been used to assess the dynamics of arctic tundra vegetation. Until recently the scientific literature has largely described the "greening" of the Arctic; from a remote sensing perspective, an increase in the Normalized Difference Vegetation Index (NDVI), or a similar satellite-based vegetation index. Vegetation increases have been heterogeneous throughout the Arctic, and were reported to be up to 25% in certain areas over a 30-year timespan. However, more recently, arctic tundra vegetation dynamics have gotten more complex, with observations of more widespread tundra "browning" being reported. We used a combination of remote sensing data, including the Global Inventory Monitoring and Modeling System (GIMMS), as well as higher spatial resolution Landsat data, to evaluate the spatio-temporal patterns of arctic tundra vegetation dynamics (greening and browning) at circumpolar and regional scales over the past 3-4 decades. At the circumpolar scale, we focus on the spatial heterogeneity (by tundra subzone and continent) of tundra browning over the past 5-15 years, followed by a more recent recovery (greening since 2015). Landsat time series allow us to evaluate the landscape-scale heterogeneity of tundra greening and browning for northern Alaska and the Yamal Peninsula in northwestern Siberia, Russia. Multi-dataset analyses reveal that tundra greening and browning (i.e. increases or decreases in the NDVI respectively) are generated by different sets of processes. Tundra greening is largely a result of either climate warming, lengthening of the growing season, or responses to disturbances, such as fires, landslides, and freeze-thaw processes. Browning on the other hand tends to be more event-driven, such as the shorter-term decline in vegetation due to fire, insect defoliation, consumption by larger herbivores, or extreme weather events (e.g. winter warming or early summer frost damage). Browning can also be caused by local or

  20. Controlled cellular energy conversion in brown adipose tissue thermogenesis

    Science.gov (United States)

    Horowitz, J. M.; Plant, R. E.

    1978-01-01

    Brown adipose tissue serves as a model system for nonshivering thermogenesis (NST) since a) it has as a primary physiological function the conversion of chemical energy to heat; and b) preliminary data from other tissues involved in NST (e.g., muscle) indicate that parallel mechanisms may be involved. Now that biochemical pathways have been proposed for brown fat thermogenesis, cellular models consistent with a thermodynamic representation can be formulated. Stated concisely, the thermogenic mechanism in a brown fat cell can be considered as an energy converter involving a sequence of cellular events controlled by signals over the autonomic nervous system. A thermodynamic description for NST is developed in terms of a nonisothermal system under steady-state conditions using network thermodynamics. Pathways simulated include mitochondrial ATP synthesis, a Na+/K+ membrane pump, and ionic diffusion through the adipocyte membrane.

  1. Juvenile-adult habitat shift in permian fossil reptiles and amphibians.

    Science.gov (United States)

    Bakker, R T

    1982-07-02

    Among extant large reptiles, juveniles often occupy different habitats from those of adults or subadults and thus avoid competition with and predation from the older animals; small juveniles often choose cryptic habitats because they are vulnerable to a wide variety of predators. Evidence from fossil humeri and femora of Early Permian reptiles collected from sediments of several distinct habitats indicate that similar shifts in habitat occurred. Juvenile Dimetrodon seem to have favored cryptic habitats around swamp and swampy lake margins; adults favored open habitats on the floodplains. Similar patterns of habitat shift seem to be present in the reptile Ophiacodon and the amphibian Eryops and may have been common in fossil tetrapods of the Permian-Triassic.

  2. Social Support, Motivation, and the Process of Juvenile Reentry: An Exploratory Analysis of Desistance

    Science.gov (United States)

    Panuccio, Elizabeth A.; Christian, Johnna; Martinez, Damian J.; Sullivan, Mercer L.

    2012-01-01

    Many scholarly works and studies have explored the experience of reentry and desistance for adult offenders, but fewer studies have focused on these processes among juvenile offenders. Using qualitative case studies of juveniles released from secure confinement, this study explores the desistance process during juvenile reentry by examining how…

  3. Blood glucose lowering effects of brown rice in normal and diabetic subjects.

    Science.gov (United States)

    Panlasigui, Leonora N; Thompson, Lilian U

    2006-01-01

    Carbohydrate foods, which produce low glycemic responses, have been shown to be beneficial in the dietary management of chronic diseases such as diabetes and hyperlipidemia. This study determined the starch digestion rate in vitro and, in a randomised crossover design, the postprandial blood glucose response of 10 healthy and nine type 2 diabetic volunteers to brown rice compared to milled rice from the same batch and variety. The total sugar released in vitro was 23.7% lower in brown rice than in milled rice. In healthy volunteers, the glycemic area and glycemic index were, respectively, 19.8% and 12.1% lower (p brown rice than milled rice, while in diabetics, the respective values were 35.2% and 35.6% lower. The effect was partly due to the higher amounts of phytic acid, polyphenols, dietary fiber and oil in brown compared to milled rice and the difference in some physicochemical properties of the rice samples such as minimum cooking time and degree of gelatinisation. In conclusion, brown rice is a more health beneficial food for diabetics and hyperglycemic individuals than milled rice.

  4. [Child-juvenile prostitution: a systematic literature review].

    Science.gov (United States)

    Ribeiro, Moneda Oliveira; Dias, Aretuzza de Fátima

    2009-06-01

    The purpose of this study was to understand how infant-juvenile prostitution is being explained by researchers through an extensive bibliographical survey on national and international scientific sources. It was possible to access 20 references in full text form, which were analyzed according to the Content Analysis method. The analysis consisted in answering how infant-juvenile prostitution is represented by the author in relation to the concepts, causes, effects and solutions described in the references. It was found that the authors approached the subject as a way of survival, resulting from an unequal society, adult-centered and male chauvinist causing mental and physical diseases in children.

  5. Gas bubble disease monitoring and research of juvenile salmonids

    International Nuclear Information System (INIS)

    Maule, A.G.; Beeman, J.; Hans, K.M.; Mesa, M.G.; Haner, P.; Warren, J.J.

    1997-10-01

    This document describes the project activities 1996--1997 contract year. This report is composed of three chapters which contain data and analyses of the three main elements of the project: field research to determine the vertical distribution of migrating juvenile salmonids, monitoring of juvenile migrants at dams on the Snake and Columbia rivers, and laboratory experiments to describe the progression of gas bubble disease signs leading to mortality. The major findings described in this report are: A miniature pressure-sensitive radio transmitter was found to be accurate and precise and, after compensation for water temperature, can be used to determine the depth of tagged-fish to within 0.32 m of the true depth (Chapter 1). Preliminary data from very few fish suggest that depth protects migrating juvenile steelhead from total dissolved gas supersaturation (Chapter 1). As in 1995, few fish had any signs of gas bubble disease, but it appeared that prevalence and severity increased as fish migrated downstream and in response to changing gas supersaturation (Chapter 2). It appeared to gas bubble disease was not a threat to migrating juvenile salmonids when total dissolved gas supersaturation was < 120% (Chapter 2). Laboratory studies suggest that external examinations are appropriate for determining the severity of gas bubble disease in juvenile salmonids (Chapter 3). The authors developed a new method for examining gill arches for intravascular bubbles by clamping the ventral aorta to reduce bleeding when arches were removed (Chapter 3). Despite an outbreak of bacterial kidney disease in the experimental fish, the data indicate that gas bubble disease is a progressive trauma that can be monitored (Chapter 3)

  6. Utilization of a major brown rust resistance gene in sugarcane breeding

    Science.gov (United States)

    Brown rust, caused by Puccinia melanocephala has had devastating effects on sugarcane (Saccharum spp.) breeding programs and on commercial production. The discovery of Bru1, a major gene conferring resistance to brown rust represented a substantial breakthrough and markers for the detection of Bru1 ...

  7. Infant and juvenile growth in ancestral Pueblo Indians.

    Science.gov (United States)

    Schillaci, Michael A; Nikitovic, Dejana; Akins, Nancy J; Tripp, Lianne; Palkovich, Ann M

    2011-06-01

    The present study examines patterns of infant and juvenile growth in a diachronic sample of ancestral Pueblo Indians (AD 1300-1680) from the American Southwest. An assessment of growth patterns is accompanied by an evaluation of pathological conditions often considered to be indicators of nutritional deficiencies and/or gastrointestinal infections. Growth patterns and the distribution of pathological conditions are interpreted relative to culturally relevant age categories defined by Puebloan rites of passage described in the ethnographic literature. A visual comparison of growth distance curves revealed that relative to a modern comparative group our sample of ancestral Pueblo infant and juveniles exhibited faltering growth beginning soon after birth to about 5 years of age. A comparison of curves describing growth relative to adult femoral length, however, indicated reduced growth occurring later, by around 2 years of age. Similar to previous studies, we observed a high proportion of nonsurvivors exhibiting porotic cranial lesions during the first 2 years of life. Contrary to expectations, infants and juveniles without evidence of porotic cranial lesions exhibited a higher degree of stunting. Our study is generally consistent with previous research reporting poor health and high mortality for ancestral Pueblo Indian infants and juveniles. Through use of a culturally relevant context defining childhood, we argue that the observed poor health and high mortality in our sample occur before the important transition from young to older child and the concomitant initial incorporation into tribal ritual organization. Copyright © 2011 Wiley-Liss, Inc.

  8. Brown Coal Dewatering Using Poly (Acrylamide-Co-Potassium Acrylic Based Super Absorbent Polymers

    Directory of Open Access Journals (Sweden)

    Sheila Devasahayam

    2015-09-01

    Full Text Available With the rising cost of energy and fuel oils, clean coal technologies will continue to play an important role during the transition to a clean energy future. Victorian brown coals have high oxygen and moisture contents and hence low calorific value. This paper presents an alternative non evaporative drying technology for high moisture brown coals based on osmotic dewatering. This involves contacting and mixing brown coal with anionic super absorbent polymers (SAP which are highly crossed linked synthetic co-polymers based on a cross-linked copolymer of acryl amide and potassium acrylate. The paper focuses on evaluating the water absorption potential of SAP in contact with 61% moisture Loy Yang brown coal, under varying SAP dosages for different contact times and conditions. The amount of water present in Loy Yang coal was reduced by approximately 57% during four hours of SAP contact. The extent of SAP brown coal drying is directly proportional to the SAP/coal weight ratio. It is observed that moisture content of fine brown coal can readily be reduced from about 59% to 38% in four hours at a 20% SAP/coal ratio.

  9. The role of innate immunity in the regulation of brown and beige adipogenesis.

    Science.gov (United States)

    Alexaki, Vasileia Ismini; Chavakis, Triantafyllos

    2016-03-01

    The adipose tissue (AT) is multifunctional, acting as an endocrine tissue and participating in the regulation of the organism's homeostasis. Metabolic, endocrine and inflammatory mechanisms are tightly intertwined within the AT, regulating its function. Disruption of the equilibrium among these mechanisms leads to pathologies, the most common being obesity-related insulin resistance. Two types of AT exist, the white and the brown AT. Traditionally the white AT (WAT) was thought to store energy in the form of lipids, while the brown AT (BAT) was known to mediate heat generation. Recently, the 'brite' or 'beige' AT was identified, which is localized predominantly in subcutaneous WAT, but shares functional features with the BAT and is capable of heat production. The major stimulus triggering beige and brown adipogenesis is cold exposure and catecholamine signalling. However, several further signals and mechanisms exist, which can orchestrate and fine-tune beige and brown AT function. Immune cells and inflammation have emerged as regulators of beige and brown AT function. The present review will focus on the recently identified crosstalk between innate immunity and the regulation of beige and brown adipogenesis.

  10. Genetic-industrial classification of brown coals in Serbia

    Energy Technology Data Exchange (ETDEWEB)

    Ercegovac, Marko [Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade (Serbia and Montenegro); ?ivotic, Dragana; Kostic, Aleksandar [University of Belgrade, Faculty of Mining and Geology, Djusina 7, 11000 Belgrade (Serbia and Montenegro)

    2006-08-01

    The petrologic, chemical and technological features of low-rank coals from nineteen of the most important basins in Serbia have been studied as part of the research project of genetic-industrial classification of low-rank coals of Serbia. Most of these features have been included as parameters of the codification system for low-rank coals. The paper discusses the main genetic, technological and supplementary parameters of the Serbian brown coals such as rank, petrographic composition, gelification degree, total moisture, ash content, sulphur content, calorific value, tar yield, the chemical composition and the thermotechnical properties of ash. The rank of brown coals from Serbia has been defined on the basis of the following parameters: random reflectance of huminite/vitrinite (R{sub r}=0.26-0.50%), total moisture (W{sup ar}=13.18-49.11%), gross calorific value (Q{sup daf}=22.3-29.2MJ/kg, dry, ash-free basis), net calorific value (Q{sup daf}=21.2-28.1MJ/kg, dry, ash-free basis). The results from the maceral analysis confirm that the humic coals, in general, are characterized by high huminite content (76.0-97.9vol.%, mineral matter free), low inertinite amount (0.7-6.3vol.%, mineral matter free), and a variable amount of liptinite (0.8-15.5vol.%, mineral matter free). It is possible to define three groups of Serbian brown coals on the basis of the primary, or genetic parameters, technological, or chemical parameters, and supplementary parameters: soft (Low-Rank C; [Economic Commission for Europe, Committee on Sustainable Energy- United Nations (ECE-UN), 1998. International Classification of in-Seam Coals. Energy 19, 41 pp.; Economic Commission for Europe, Committee on Sustainable Energy- United Nations (ECE-UN), 1999. International Codification System for Low-Rank Coals. Energy 9, 19 pp.; Economic Commission for Europe, Committee on Sustainable Energy- United Nations (ECE-UN), 2000. International Classification for Low-Rank Coals. Energy 12, 21 pp.]), dull (Low

  11. Regulation of white and brown adipocyte differentiation by RhoGAP DLC1.

    Directory of Open Access Journals (Sweden)

    Choon Kiat Sim

    Full Text Available Adipose tissues constitute an important component of metabolism, the dysfunction of which can cause obesity and type II diabetes. Here we show that differentiation of white and brown adipocytes requires Deleted in Liver Cancer 1 (DLC1, a Rho GTPase Activating Protein (RhoGAP previously studied for its function in liver cancer. We identified Dlc1 as a super-enhancer associated gene in both white and brown adipocytes through analyzing the genome-wide binding profiles of PPARγ, the master regulator of adipogenesis. We further observed that Dlc1 expression increases during differentiation, and knockdown of Dlc1 by siRNA in white adipocytes reduces the formation of lipid droplets and the expression of fat marker genes. Moreover, knockdown of Dlc1 in brown adipocytes reduces expression of brown fat-specific genes and diminishes mitochondrial respiration. Dlc1-/- knockout mouse embryonic fibroblasts show a complete inability to differentiate into adipocytes, but this phenotype can be rescued by inhibitors of Rho-associated kinase (ROCK and filamentous actin (F-actin, suggesting the involvement of Rho pathway in DLC1-regulated adipocyte differentiation. Furthermore, PPARγ binds to the promoter of Dlc1 gene to regulate its expression during both white and brown adipocyte differentiation. These results identify DLC1 as an activator of white and brown adipocyte differentiation, and provide a molecular link between PPARγ and Rho pathways.

  12. Direct bioconversion of brown algae into ethanol by thermophilic bacterium Defluviitalea phaphyphila.

    Science.gov (United States)

    Ji, Shi-Qi; Wang, Bing; Lu, Ming; Li, Fu-Li

    2016-01-01

    Brown algae are promising feedstocks for biofuel production with inherent advantages of no structural lignin, high growth rate, and no competition for land and fresh water. However, it is difficult for one microorganism to convert all components of brown algae with different oxidoreduction potentials to ethanol. Defluviitalea phaphyphila Alg1 is the first characterized thermophilic bacterium capable of direct utilization of brown algae. Defluviitalea phaphyphila Alg1 can simultaneously utilize mannitol, glucose, and alginate to produce ethanol, and high ethanol yields of 0.47 g/g-mannitol, 0.44 g/g-glucose, and 0.3 g/g-alginate were obtained. A rational redox balance system under obligate anaerobic condition in fermenting brown algae was revealed in D. phaphyphila Alg1 through genome and redox analysis. The excess reducing equivalents produced from mannitol metabolism were equilibrated by oxidizing forces from alginate assimilation. Furthermore, D. phaphyphila Alg1 can directly utilize unpretreated kelp powder, and 10 g/L of ethanol was accumulated within 72 h with an ethanol yield of 0.25 g/g-kelp. Microscopic observation further demonstrated the deconstruction process of brown algae cell by D. phaphyphila Alg1. The integrated biomass deconstruction system of D. phaphyphila Alg1, as well as its high ethanol yield, provided us an excellent alternative for brown algae bioconversion at elevated temperature.

  13. Production of the blood pressure lowing peptides from brown alga ( Undaria pinnatifida)

    Science.gov (United States)

    Minoru, Sato; Takashi, Oba; Takao, Hosokawa; Toshiyasu, Yamaguchi; Toshiki, Nakano; Tadao, Saito; Koji, Muramoto; Takashi, Kahara; Katsura, Funayama; Akio, Kobayashi; Takahisa, Nakano

    2005-07-01

    Brown alga ( Undaria pinnatifida) was treated with alginate lyase and hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme (ACE) was measured. Four hydrolysates with potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHRs). The systolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by protease S ‘Amano’ (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1. In the 17 weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10 weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressed for 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction and HPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid composition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, and Leu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. The brown alga hydrolysates were also confirmed to decrease the blood pressure in humans.

  14. Differences in intermediary energy metabolism between juvenile and adult Fasciola hepatica

    NARCIS (Netherlands)

    Tielens, A.G.M.; Heuvel, J.M. van den; Bergh, S.G. van den

    A comparison of glucose catabolism by juvenile and adult liver flukes, Fasciola hepatica, showed that in the adult the cytosolic degradation of glucose via phosphoenolpyruvate carboxykinase (PEPCK) was the most important route, whereas in the freshly excysted juvenile a large part was degraded via

  15. Studies on physical performance and functional ability in juvenile idiopathic arthritis

    NARCIS (Netherlands)

    Takken, T.

    2003-01-01

    There is a growing interest in the physical training possibilities of children with juvenile arthritis. In the first Chapter a brief introduction on physical fitness and physical training is given including an overview of the existing studies in juvenile arthritis patients. In Chapter 2, we

  16. La política pública de las orquestas infanto-juveniles

    Directory of Open Access Journals (Sweden)

    María Villalba

    2010-01-01

    Full Text Available En este artículo me propongo abordar los proyectos de orquestas infanto-juveniles como política pública diseñada con la intención de posibilitar el proceso de integración social de grupos infanto-juveniles en situación de empobrecimiento en la Ciudad Autónoma de Buenos Aires y en la Provincia de Buenos Aires, Argentina, durante el período 1998 - 2010, tomando las prácticas de algunas de las orquestas desarrolladas en el marco de los proyectos de "Orquestas Infanto-Juveniles" (POIJ y de "Orquesta Escuela" (POE respectivamente.

  17. Black-Brown Relations and Stereotypes.

    Science.gov (United States)

    Mindiola, Tatcho Jr.; Niemann, Yolanda Flores; Rodriguez, Nestor

    This book analyzes how African and Hispanic Americans perceive and interact with one another, highlighting black-brown relations in Houston, Texas, one of the largest cities with a majority ethnic population and one in which Hispanic Americans outnumber African Americans. Using results from several sociological studies, the book examines: how each…

  18. Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST).

    Science.gov (United States)

    Nigrovic, Peter A; Beukelman, Timothy; Tomlinson, George; Feldman, Brian M; Schanberg, Laura E; Kimura, Yukiko

    2018-03-01

    Systemic juvenile idiopathic arthritis is a rare febrile arthritis of childhood characterized by a potentially severe course, including prolonged glucocorticoid exposure, growth failure, destructive arthritis, and life-threatening macrophage activation syndrome. Early cytokine-blocking biologic therapy may improve long-term outcomes, although some systemic juvenile idiopathic arthritis patients respond well to non-biologic treatment, leaving optimal management undefined. Consequently, treatment of new-onset systemic juvenile idiopathic arthritis by expert clinicians varies widely. To describe a pragmatic, observational comparative effectiveness study that takes advantage of diversity in the management of a rare disease: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST), comparing non-biologic and biologic consensus treatment plans for new-onset systemic juvenile idiopathic arthritis within the 60-center Childhood Arthritis and Rheumatology Research Alliance Registry (CARRA). FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST) is a multicenter, prospective, non-randomized study that compares four Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans for new-onset systemic juvenile idiopathic arthritis: (1) glucocorticoids alone, (2) methotrexate, (3) interleukin-1 blockade, and (4) interleukin-6 blockade. Patients consenting to participation in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry are started on one of four Consensus Treatment Plans at the discretion of the treating physician. The outcome of primary interest is clinically inactive disease off glucocorticoids at 9 months, comparing non-biologic (Consensus Treatment Plans 1 + 2) versus biologic (Consensus Treatment Plans 3 + 4) strategies. Bayesian analytic methods will be employed to evaluate response rates, using propensity scoring to balance treatment groups for potential

  19. Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis.

    LENUS (Irish Health Repository)

    Gunawardena, H

    2009-06-01

    OBJECTIVE: The identification of novel autoantibodies in juvenile dermatomyositis (DM) may have etiologic and clinical implications. The aim of this study was to describe autoantibodies to a 140-kd protein in children recruited to the Juvenile DM National Registry and Repository for UK and Ireland. METHODS: Clinical data and sera were collected from children with juvenile myositis. Sera that recognized a 140-kd protein by immunoprecipitation were identified. The identity of the p140 autoantigen was investigated by immunoprecipitation\\/immunodepletion, using commercial monoclonal antibodies to NXP-2, reference anti-p140, and anti-p155\\/140, the other autoantibody recently described in juvenile DM. DNA samples from 100 Caucasian children with myositis were genotyped for HLA class II haplotype associations and compared with those from 864 randomly selected UK Caucasian control subjects. RESULTS: Sera from 37 (23%) of 162 patients with juvenile myositis were positive for anti-p140 autoantibodies, which were detected exclusively in patients with juvenile DM and not in patients with juvenile DM-overlap syndrome or control subjects. No anti-p140 antibody-positive patients were positive for other recognized autoantibodies. Immunodepletion suggested that the identity of p140 was consistent with NXP-2 (the previously identified MJ autoantigen). In children with anti-p140 antibodies, the association with calcinosis was significant compared with the rest of the cohort (corrected P < 0.005, odds ratio 7.0, 95% confidence interval 3.0-16.1). The clinical features of patients with anti-p140 autoantibodies were different from those of children with anti-p155\\/140 autoantibodies. The presence of HLA-DRB1*08 was a possible risk factor for anti-p140 autoantibody positivity. CONCLUSION: This study has established that anti-p140 autoantibodies represent a major autoantibody subset in juvenile DM. This specificity may identify a further immunogenetic and clinical phenotype within the

  20. Three-dimensional migration behavior of juvenile salmonids in reservoirs and near dams

    OpenAIRE

    Li, Xinya; Deng, Zhiqun D.; Fu, Tao; Brown, Richard S.; Martinez, Jayson J.; McMichael, Geoffrey A.; Trumbo, Bradly A.; Ahmann, Martin L.; Renholds, Jon F.; Skalski, John R.; Townsend, Richard L.

    2018-01-01

    To acquire 3-D tracking data on juvenile salmonids, Juvenile Salmon Acoustic Telemetry System (JSATS) cabled hydrophone arrays were deployed in the forebays of two dams on the Snake River and at a mid-reach reservoir between the dams. The depth distributions of fish were estimated by statistical analyses performed on large 3-D tracking data sets from ~33,500 individual acoustic tagged yearling and subyearling Chinook salmon and juvenile steelhead at the two dams in 2012 and subyearling Chinoo...

  1. A combination of body condition measurements is more informative than conventional condition indices: temporal variation in body condition and corticosterone in brown tree snakes (Boiga irregularis).

    Science.gov (United States)

    Waye, Heather L; Mason, Robert T

    2008-02-01

    The body condition index is a common method for quantifying the energy reserves of individual animals. Because good body condition is necessary for reproduction in many species, body condition indices can indicate the potential reproductive output of a population. Body condition is related to glucocorticoid production, in that low body condition is correlated to high concentrations of corticosterone in reptiles. We compared the body condition index and plasma corticosterone levels of brown tree snakes on Guam in 2003 to those collected in 1992/1993 to determine whether that population still showed the chronic stress and poor condition apparent in the earlier study. We also examined the relationship between fat mass, body condition and plasma corticosterone concentrations as indicators of physiological condition of individuals in the population. Body condition was significantly higher in 2003 than in the earlier sample for mature male and female snakes, but not for juveniles. The significantly lower levels of corticosterone in all three groups in 2003 suggests that although juveniles did not have significantly improved energy stores they, along with the mature males and females, were no longer under chronic levels of stress. Although the wet season of 2002 was unusually rainy, low baseline levels of corticosterone measured in 2000 indicate that the improved body condition of snakes in 2003 is likely the result of long-term changes in prey populations rather than annual variation in response to environmental conditions.

  2. Inhibition of tyrosinase-mediated enzymatic browning by sulfite and natural alternatives

    NARCIS (Netherlands)

    Kuijpers, T.F.M.; Vincken, J.P.

    2013-01-01

    Although sulfite is widely used to counteract enzymatic browning, its mechanism has remained largely unknown. We describe a double inhibitory mechanism of sulfite on enzymatic browning, affecting both the enzymatic oxidation of phenols into o‑quinones, as well as the non‑enzymatic

  3. Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes.

    Science.gov (United States)

    Lone, Jameel; Yun, Jong Won

    2016-05-15

    Several dietary compounds that are able to induce the brown fat-like phenotype in white adipocytes have been considered for treatment of obesity due to their ability to increase energy expenditure. Here, we report that limonene induces the brown fat-like phenotype in 3T3-L1 adipocytes by increasing expression of brown adipocyte-specific genes and proteins. Limonene-induced browning in white adipocytes was investigated by determining expression levels of brown fat-specific genes and proteins by real-time RT-PCR, immunoblot analysis, and immunocytochemical staining. Limonene enhanced mitochondrial biogenesis, as evidenced by increased mitochondrial content and immunofluorescent intensity. Limonene also significantly elevated protein levels of HSL, PLIN, p-AMPK, p-ACC, ACO, COX4, CPT1, and CYT C, suggesting its possible role in enhancement of lipolysis and lipid catabolism. Increased expression of PRDM16, UCP1, C/EBPβ, and other brown fat-specific markers by limonene was possibly mediated by activation of β3-adnergenic receptor (β3-AR), as inhibition of β3-AR inhibited up-regulation of brown fat-specific markers. Similarly, limonene-mediated activation of ERK and up-regulation of key brown adipocyte specific markers were eliminated by treatment with ERK antagonist. Taken together, these results suggest that limonene induces browning of 3T3-L1 adipocytes via activation of β3-AR and the ERK signaling pathway. In conclusion, our findings suggest that limonene plays a dual modulatory role in induction of the brown adipocyte-like phenotype as well as promotion of lipid metabolism and thus may have potential therapeutic implications for treatment of obesity. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Population II brown dwarfs and dark haloes

    International Nuclear Information System (INIS)

    Zinnecker, H.

    1986-01-01

    Opacity-limited fragmentation is investigated as a function of the dust-to-gas ratio and it is found that the characteristic protostellar mass Msub(*) is metallicity-dependent. This dependence is such that, for the low metallicity gas out of which the stars of Population II formed in the halo, Msub(*) is less than 0.1 M solar mass. If applicable, these theoretical considerations would predict that substellar masses have formed more frequently under the metal-poor conditions in the early Galaxy (Population II brown dwarfs). Thus the missing mass in the Galactic halo and in the dark haloes around other spirals may well reside in these metal-poor Population II brown dwarfs. (author)

  5. Utilization in rats of 14C-L-lysine-labeled casein browned by amino-carbonyl reaction

    International Nuclear Information System (INIS)

    Mori, Bunpei; Nakatsuji, Hirotaka.

    1977-01-01

    The investigation was carried out in order to elucidate the reason for the reduction in nutritive value of browned protein, by using labeled casein as a model protein. Goat casein preparation in which lysine residues had been labeled with 14 C was browned by amino-carbonyl reaction with glucose at 37 0 C. Browned or non-browned casein was ingested by growing rats by spaced feeding. When the rats ingested the browned casein the experimental group, higher radioactivity was found in TCA-soluble fraction in the small intestine as compared with that in the control group, while radioactivity was scarecely found in feces for 22 hr. Along with absorption delay, considerably high radioactivity was found in urine. The recovery of radioactivity in expired air of rats fed the labeled casein (browned and non-browned) was measured. In the experimental group, expired 14 CO 2 came out slower than the control group. From these results, it is suggested that the main reason for the reduction in nutritive value by browning reaction may be the formation of a lysine derivative in a protein, which remains in the small intestinal lumen as an absorption-delayed material and is finally excreted in urine. (auth.)

  6. Multi-party quantum key agreement with five-qubit brown states

    Science.gov (United States)

    Cai, Tao; Jiang, Min; Cao, Gang

    2018-05-01

    In this paper, we propose a multi-party quantum key agreement protocol with five-qubit brown states and single-qubit measurements. Our multi-party protocol ensures each participant to contribute equally to the agreement key. Each party performs three single-qubit unitary operations on three qubits of each brown state. Finally, by measuring brown states and decoding the measurement results, all participants can negotiate a shared secret key without classical bits exchange between them. With the analysis of security, our protocol demonstrates that it can resist against both outsider and participant attacks. Compared with other schemes, it also possesses a higher information efficiency. In terms of physical operation, it requires single-qubit measurements only which weakens the hardware requirements of participant and has a better operating flexibility.

  7. Juvenile xanthogranuloma of the corneoscleral limbus: case report and review of the literature.

    Science.gov (United States)

    Chaudhry, Imtiaz A; Al-Jishi, Zohair; Shamsi, Farrukh A; Riley, Fenwick

    2004-01-01

    Juvenile xanthogranuloma is a benign histiocytic cutaneous disorder mainly occurring in infants which may affect the eye. Ocular manifestations usually present in the form of iris lesions with secondary hyphema and glaucoma, but juvenile xanthogranuloma may also present as a corneoscleral limbal mass. We present the case of an 18-month-old female infant with ocular juvenile xanthogranuloma occurring as a corneoscleral limbal mass without associated cutaneous or systemic findings. The limbal mass lesion was excised by lamellar dissection and histopathological studies revealed histiocytes admixed with lymphocytes, plasma cells, and eosinophils; foreign body and Touton giant cells present throughout the specimen confirmed the diagnosis of juvenile xanthogranuloma. At 14-month follow-up, there was no recurrence of the limbal mass. The natural history of this uncommon ocular condition is discussed and the relevant literature reviewed. Juvenile xanthogranuloma should be considered in the differential diagnosis of any corneoscleral limbal mass lesion, particularly in children.

  8. Foraging behaviour of juvenile female New Zealand sea lions (Phocarctos hookeri in contrasting environments.

    Directory of Open Access Journals (Sweden)

    Elaine S Leung

    Full Text Available Foragers can show adaptive responses to changes within their environment through morphological and behavioural plasticity. We investigated the plasticity in body size, at sea movements and diving behaviour of juvenile female New Zealand (NZ sea lions (Phocarctos hookeri in two contrasting environments. The NZ sea lion is one of the rarest pinnipeds in the world. Most of the species is based at the subantarctic Auckland Islands (AI; considered to be marginal foraging habitat, with a recolonizing population on the Otago Peninsula, NZ mainland (considered to be more optimal habitat. We investigated how juvenile NZ sea lions adjust their foraging behaviour in contrasting environments by deploying satellite-linked platform transmitting terminals (PTTs and time-depth recorders (TDRs on 2-3 year-old females at AI (2007-2010 and Otago (2009-2010. Juvenile female NZ sea lions exhibited plasticity in body size and behaviour. Otago juveniles were significantly heavier than AI juveniles. Linear mixed effects models showed that study site had the most important effect on foraging behaviour, while mass and age had little influence. AI juveniles spent more time at sea, foraged over larger areas, and dove deeper and longer than Otago juveniles. It is difficult to attribute a specific cause to the observed contrasts in foraging behaviour because these differences may be driven by disparities in habitat/prey characteristics, conspecific density levels or interseasonal variation. Nevertheless, the smaller size and increased foraging effort of AI juveniles, combined with the lower productivity in this region, support the hypothesis that AI are less optimal habitat than Otago. It is more difficult for juveniles to forage in suboptimal habitats given their restricted foraging ability and lower tolerance for food limitation compared to adults. Thus, effective management measures should consider the impacts of low resource environments, along with changes that can

  9. Development trends in the Lusatian brown coal mining industry

    International Nuclear Information System (INIS)

    Schwirten, D.

    1994-01-01

    Lusatia has lived on and with brown coal for over 200 years. Brown coal changed what was once a region in which forestry and agriculture predominated into an industrial region. Thanks to its good combustion properties and high energy yield brown coal very soon became known and popular. It was always the driving force for a rapid development which resulted in an economically sound and technically up-to-date industry in Lusatia. This powerful status of brown coal was however soon exploited for aims which were bound to lead to the downfall of two social structures (during the years from 1933 to 1990) by reason of a regime of unconditional autarchy. The economic and technical development thus initiated certainly brought many advantages, but it also had serious diadvantages. Constant increases in production, as a result of which planned rated outputs were intentionally disregarded, were the rule because production targets had to be met or exceeded. Economic inefficiency led to a scarcity of labour and a shortage of finances. Environmental aims had no priority since production was the absolute, primary objective. Consequently, this regime of economic autarchy ended in an one-way street as far as industry was concerned, a situation which was accompanied by an unexampled destruction of the natural basic living conditions and direct, threatening health hazards to man and nature. The year 1990 saw the beginning of the transition from planned controlled economy to free market economy. The reorganization of the former large combines as corporations was not however merely a formal change, but internally also represented a transformation. The brown coal mining industry manifested its new intention and determination to be economically competitive and unsubsidized in future, to operate in such a way as to be compatible with the environment and to exploit reserves carefully, as well as to render its activities socially compatible. (orig.) [de

  10. Database for content of mercury in Polish brown coal

    Science.gov (United States)

    Jastrząb, Krzysztof

    2018-01-01

    Poland is rated among the countries with largest level of mercury emission in Europe. According to information provided by the National Centre for Balancing and Management of Emissions (KOBiZE) more than 10.5 tons of mercury and its compounds were emitted into the atmosphere in 2015 from the area of Poland. Within the scope of the BazaHg project lasting from 2014 to 2015 and co-financed from the National Centre of Research and Development (NCBiR) a database was set up with specification of mercury content in Polish hard steam coal, coking coal and brown coal (lignite) grades. With regard to domestic brown coal the database comprises information on coal grades from Brown Coal Mines of `Bełchatów', `Adamów', `Turów' and `Sieniawa'. Currently the database contains 130 records with parameters of brown coal, where each record stands for technical analysis (content of moisture, ash and volatile particles), elemental analysis (CHNS), content of chlorine and mercury as well as net calorific value and combustion heat. Content of mercury in samples of brown coal grades under test ranged from 44 to 985 μg of Hg/kg with the average level of 345 μg of Hg/kg. The established database makes up a reliable and trustworthy source of information about content of mercury in Polish fossils. The foregoing details completed with information about consumption of coal by individual electric power stations and multiplied by appropriate emission coefficients may serve as the background to establish loads of mercury emitted into atmosphere from individual stations and by the entire sector of power engineering in total. It will also enable Polish central organizations and individual business entities to implement reasonable policy with respect of mercury emission into atmosphere.

  11. Molecular phylogeography of the brown bear (Ursus arctos) in Northeastern Asia based on analyses of complete mitochondrial DNA sequences.

    Science.gov (United States)

    Hirata, Daisuke; Mano, Tsutomu; Abramov, Alexei V; Baryshnikov, Gennady F; Kosintsev, Pavel A; Vorobiev, Alexandr A; Raichev, Evgeny G; Tsunoda, Hiroshi; Kaneko, Yayoi; Murata, Koichi; Fukui, Daisuke; Masuda, Ryuichi

    2013-07-01

    To further elucidate the migration history of the brown bears (Ursus arctos) on Hokkaido Island, Japan, we analyzed the complete mitochondrial DNA (mtDNA) sequences of 35 brown bears from Hokkaido, the southern Kuril Islands (Etorofu and Kunashiri), Sakhalin Island, and the Eurasian Continent (continental Russia, Bulgaria, and Tibet), and those of four polar bears. Based on these sequences, we reconstructed the maternal phylogeny of the brown bear and estimated divergence times to investigate the timing of brown bear migrations, especially in northeastern Eurasia. Our gene tree showed the mtDNA haplotypes of all 73 brown and polar bears to be divided into eight divergent lineages. The brown bear on Hokkaido was divided into three lineages (central, eastern, and southern). The Sakhalin brown bear grouped with eastern European and western Alaskan brown bears. Etorofu and Kunashiri brown bears were closely related to eastern Hokkaido brown bears and could have diverged from the eastern Hokkaido lineage after formation of the channel between Hokkaido and the southern Kuril Islands. Tibetan brown bears diverged early in the eastern lineage. Southern Hokkaido brown bears were closely related to North American brown bears.

  12. SMA and CARMA observations of young brown dwarfs in ρ Ophiuchi and Taurus

    Directory of Open Access Journals (Sweden)

    Lee C.-F.

    2011-07-01

    Full Text Available Molecular outflows provide vital information about the earliest stages in the birth of stars, studying the molecular outflow properties is therefore crucial for understanding how stars form. Brown dwarfs with masses between that of stars and planets are not massive enough to maintain stable hydrogen-burning fusion reactions during most of their lifetime. Their origins are subject to much debate in recent literature because their masses are far below the typical mass where core collapse is expected to occur. Based on Submillimeter Array (SMA and Combined Array for Research in Millimeter-wave Astronomy (CARMA observations, we present the first detections of bipolar molecular outflows from young brown dwarfs in ρ Ophiuchi and Taurus. Our results demonstrate that the bipolar molecular outflow operates down to brown dwarf masses, occurring in brown dwarfs as a scaled-down version of the universal process seen in young low-mass stars. This demonstrates that brown dwarfs and low-mass stars likely share the same formation mechanism.

  13. The physiological basis of the migration continuum in brown trout ( Salmo trutta)

    DEFF Research Database (Denmark)

    Boel, Mikkel; Aarestrup, Kim; Baktoft, Henrik

    2014-01-01

    Partial migration is common in many animal taxa; however, the physiological variation underpinning migration strategies remains poorly understood. Among salmonid fishes, brown trout (Salmo trutta) is one of the species that exhibits the most complex variation in sympatric migration strategies......, expressed as a migration continuum, ranging from residency to anadromy. In looking at brown trout, our objective with this study was to test the hypothesis that variation in migration strategies is underpinned by physiological variation. Prior to migration, physiological samples were taken from fish...... in brown trout....

  14. An historical perspective - Brown is not a color. [astrophysics of infrared dwarf stars

    Science.gov (United States)

    Tarter, J. C.

    1986-01-01

    Major shifts in theoretical understanding of the star formation process and the possible components of the local mass density are reviewed. Those aspects of brown dwarf structure and evolution that are still not well enough understood are outlined, and the types of observations that might force the modification of current theories to accommodate the existence of brown dwarfs are suggested. The appropriateness of the name 'brown dwarf' is defended.

  15. Genetic characterization of Kenai brown bears (Ursus arctos): Microsatellite and mitochondrial DNA control region variation in brown bears of the Kenai Peninsula, south central Alaska

    Science.gov (United States)

    Jackson, J.V.; Talbot, S.L.; Farley, S.

    2008-01-01

    We collected data from 20 biparentally inherited microsatellite loci, and nucleotide sequence from the maternally inherited mitochondrial DNA (mtDNA) control region, to determine levels of genetic variation of the brown bears (Ursus arctos L., 1758) of the Kenai Peninsula, south central Alaska. Nuclear genetic variation was similar to that observed in other Alaskan peninsular populations. We detected no significant inbreeding and found no evidence of population substructuring on the Kenai Peninsula. We observed a genetic signature of a bottleneck under the infinite alleles model (IAM), but not under the stepwise mutation model (SMM) or the two-phase model (TPM) of microsatellite mutation. Kenai brown bears have lower levels of mtDNA haplotypic diversity relative to most other brown bear populations in Alaska. ?? 2008 NRC.

  16. Representing the Inuit in Contemporary British and Canadian Juvenile Non-Fiction.

    Science.gov (United States)

    David, Robert G.

    2001-01-01

    Examines text and pictorial representations of the Inuit in juvenile reference books and in geographical and historical juvenile non-fiction works. Finds continuing prevalence of a wide range of stereotypes. Identifies strengths and weaknesses of a variety of such representations, aided by a discussion group of Inuit people. (SR)

  17. The Effect of Irradiation Treatment on the Non-Enzymatic Browning Reaction in Legume Seeds

    International Nuclear Information System (INIS)

    El-Niely, H.F.G.

    2013-01-01

    The present study was conducted to evaluate the effects of gamma irradiation treatment, at room temperature, on the non-enzymatic browning reaction (Millerd reaction products, MRPs) generated in soybeans, broad beans and dried peas seeds at dose levels of 10, 30 and 60 kGy and their effects on the chemical constituents, soluble protein, available lysine and in vitro protein digestibility. The formation of MRPs in the studied legumes was assayed by monitoring the formation of brown pigments (browning intensity) by spectrophotometric method. The results revealed that the chemical composition of irradiated legumes showed non-significant differences relative to the raw one. A dose dependent decrease in soluble proteins and available lysine in the three legumes were observed. The non-enzymatic browning reaction was significantly increased with increasing the radiation dose, which was proved by changes in browning index tests. At the same time, the in vitro protein digestibility was increased after irradiation up to 60 kGy. Irradiation of dried peas with 60 kGy produced higher browning index than the other legumes. A positive correlation was observed between the radiation dose and the browning index for soybeans (R2= 0.96), broad beans (R2 = 0.81) and dried peas (R2 = 0.97) which means that 96%, 81% and 97 of the variation in the incidence of non-enzymatic browning reaction in soybean, broad bean and dried peas, respectively, are due to the effect of irradiation treatments. The present study suggests that the formation of non-enzymatic browning reaction did not impair the nutritional quality of legumes, therefore, the process of irradiation was helpful in increasing the in vitro protein digestibility of studied legumes. These results clearly indicated that gamma irradiation processing at the studied doses can add valuable effects to the studied legumes

  18. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis.

    Science.gov (United States)

    Mouri, Akihiro; Ukai, Mayu; Uchida, Mizuki; Hasegawa, Sho; Taniguchi, Masayuki; Ito, Takahiro; Hida, Hirotake; Yoshimi, Akira; Yamada, Kiyofumi; Kunimoto, Shohko; Ozaki, Norio; Nabeshima, Toshitaka; Noda, Yukihiro

    2018-05-01

    Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat stress exposure as juveniles on neuropsychological behaviors, and the causal role of glucocorticoids in abnormal behaviors and impairment of neurogenesis in mice exposed to the stress. The juvenile (24-day-old) and adult (70-day-old) male C57BL/6J mice were exposed to social defeat stress induced by an aggressive ICR mouse. Social defeat stress exposure as juveniles, even for 1 day, induced persistent social avoidance to the unfamiliar ICR mouse in the social interaction test, but that was not observed in mice exposed to the stress as adults. Social avoidance by the stress exposure as juveniles for 10 consecutive days was observed, when the target mouse was not only unfamiliar ICR but also another C57BL/J mouse, but not an absent or an anesthetized ICR mouse. The stress exposure did not induce anxiety- and depression-like behaviors in spontaneous locomotor activity, elevated plus-maze test, marble-burying test, forced swimming test, or sucrose preference test. Serum corticosterone levels increased immediately after the stress exposure. The hippocampal neurogenesis was suppressed 1 day and 4 weeks after the stress exposure. Administration of mifepristone, a glucocorticoid receptor antagonist, prior to each stress exposure, blocked the persistent social avoidance and suppression of neurogenesis. In conclusion, social avoidance induced by social defeat stress exposure as juveniles are more persistent than that as adults. These social avoidances are associated with suppression of hippocampal neurogenesis via glucocorticoid receptors. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. The effect of excluding juveniles on apparent adult olive baboons (Papio anubis) social networks

    Science.gov (United States)

    Fedurek, Piotr; Lehmann, Julia

    2017-01-01

    In recent years there has been much interest in investigating the social structure of group living animals using social network analysis. Many studies so far have focused on the social networks of adults, often excluding younger, immature group members. This potentially may lead to a biased view of group social structure as multiple recent studies have shown that younger group members can significantly contribute to group structure. As proof of the concept, we address this issue by investigating social network structure with and without juveniles in wild olive baboons (Papio anubis) at Gashaka Gumti National Park, Nigeria. Two social networks including all independently moving individuals (i.e., excluding dependent juveniles) were created based on aggressive and grooming behaviour. We used knockout simulations based on the random removal of individuals from the network in order to investigate to what extent the exclusion of juveniles affects the resulting network structure and our interpretation of age-sex specific social roles. We found that juvenile social patterns differed from those of adults and that the exclusion of juveniles from the network significantly altered the resulting overall network structure. Moreover, the removal of juveniles from the network affected individuals in specific age-sex classes differently: for example, including juveniles in the grooming network increased network centrality of adult females while decreasing centrality of adult males. These results suggest that excluding juveniles from the analysis may not only result in a distorted picture of the overall social structure but also may mask some of the social roles of individuals belonging to different age-sex classes. PMID:28323851

  20. Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats.

    Science.gov (United States)

    Fuentes, Silvia; Carrasco, Javier; Armario, Antonio; Nadal, Roser

    2014-08-01

    Exposure to stress during childhood and adolescence increases vulnerability to developing several psychopathologies in adulthood and alters the activity of the hypothalamic-pituitary-adrenal (HPA) axis, the prototypical stress system. Rodent models of juvenile stress appear to support this hypothesis because juvenile stress can result in reduced activity/exploration and enhanced anxiety, although results are not always consistent. Moreover, an in-depth characterization of changes in the HPA axis is lacking. In the present study, the long-lasting effects of juvenile stress on adult behavior and HPA function were evaluated in male rats. The juvenile stress consisted of a combination of stressors (cat odor, forced swim and footshock) during postnatal days 23-28. Juvenile stress reduced the maximum amplitude of the adrenocorticotropic hormone (ACTH) levels (reduced peak at lights off), without affecting the circadian corticosterone rhythm, but other aspects of the HPA function (negative glucocorticoid feedback, responsiveness to further stressors and brain gene expression of corticotrophin-releasing hormone and corticosteroid receptors) remained unaltered. The behavioral effects of juvenile stress itself at adulthood were modest (decreased activity in the circular corridor) with no evidence of enhanced anxiety. Imposition of an acute severe stressor (immobilization on boards, IMO) did not increase anxiety in control animals, as evaluated one week later in the elevated-plus maze (EPM), but it potentiated the acoustic startle response (ASR). However, acute IMO did enhance anxiety in the EPM, in juvenile stressed rats, thereby suggesting that juvenile stress sensitizes rats to the effects of additional stressors. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Maxillary brown tumor associated with chronic kidney failure: a case report

    Directory of Open Access Journals (Sweden)

    Stênio Medeiros Queiroz

    2013-12-01

    Full Text Available The brown tumor is a bone lesion that may affect the entire skeleton, including the maxillary bones. These tumors are characterized as focal giant cell lesions that may be associated with primary or secondary hyperparathyroidism (HPT. Brown tumors are invasive in some cases and an association with chronic renal failure (CRF has been reported. With the aim to facilitate the differential diagnosis of bone lesions that may affect dialysis patients, this paper describes a case of brown tumor in a 36- year old patient with CRF, secondary HPT carrier, who had a lesion on the right maxilla for approximately five months.

  2. Juvenile xanthogranuloma with clonal proliferation in the bone marrow.

    Science.gov (United States)

    Mały, Ewa; Przyborska, Marta; Rybczyńska, Aleksandra; Konatkowska, Benigna; Nowak, Jerzy; Januszkiewicz, Danuta

    2012-04-01

    The triple association between juvenile xanthogranuloma (JXG), juvenile myelomonocytic leukemia and neurofibromatosis was described in literature in about 20 cases. In this paper, the case of an 11-month-old infant boy with a disseminated JXG with unusual cytogenetic representation in the bone marrow was reported. Neurofibromatosis and juvenile myelomonocytic leukemia were excluded, just the same as other leukemias. Bone marrow and peripheral blood cytogenetic analysis revealed a karyotype with many rearrangements 46,XY,-6,der(12)t(6;12)(p21;p13),del(7)(p13p22),+9 once described in the literature as a B-acute lymphoblastic leukemia case. On the contrary, in our patient immunologic testing demonstrated a high activity of T lymphocytes, however, inflammation was excluded. To the best of our knowledge this is the first described case of systemic JXG with determined karyotype representing unusual chromosomal aberrations.

  3. Brown-McLean Syndrome in a Pediatric Patient

    Science.gov (United States)

    Tourkmani, Abdo Karim; Martinez, Jaime D.; Berrones, David; Juárez-Domínguez, Brenda Y.; Beltrán, Francisco; Galor, Anat

    2015-01-01

    The purpose of this manuscript is to report the case of a 12-year-old patient who presented for routine ophthalmic examination after congenital cataract surgery performed at 2 months of age. The patient was diagnosed with bilateral Brown-McLean syndrome by slit lamp examination. No treatment was required because the patient was asymptomatic and had a clear central cornea. This is the first described case of Brown-McLean syndrome in a pediatric patient, representing the importance of clinical examination in the pediatric age group after cataract surgery because of the risk for patients of developing peripheral edema. PMID:26034485

  4. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Ha-Won; Choi, Ran Hee; McClellan, Jamie L. [Division of Applied Physiology, Department of Exercise Science, University of South Carolina, Columbia, SC 29208 (United States); Piroli, Gerardo G.; Frizzell, Norma [Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208 (United States); Tseng, Yu-Hua; Goodyear, Laurie J. [Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215 (United States); Koh, Ho-Jin, E-mail: kohh@mailbox.sc.edu [Division of Applied Physiology, Department of Exercise Science, University of South Carolina, Columbia, SC 29208 (United States)

    2016-02-19

    Recent studies have demonstrated that adult humans have substantial amounts of functioning brown adipose tissue (BAT). Since BAT has been implicated as an anti-obese and anti-diabetic tissue, it is important to understand the signaling molecules that regulate BAT function. There has been a link between insulin signaling and BAT metabolism as deletion or pharmaceutical inhibition of insulin signaling impairs BAT differentiation and function. Tribbles 3 (TRB3) is a pseudo kinase that has been shown to regulate metabolism and insulin signaling in multiple tissues but the role of TRB3 in BAT has not been studied. In this study, we found that TRB3 expression was present in BAT and overexpression of TRB3 in brown preadipocytes impaired differentiation and decreased expression of BAT markers. Furthermore, TRB3 overexpression resulted in significantly lower oxygen consumption rates for basal and proton leakage, indicating decreased BAT activity. Based on previous studies showing that deletion or pharmaceutical inhibition of insulin signaling impairs BAT differentiation and function, we assessed insulin signaling in brown preadipocytes and BAT in vivo. Overexpression of TRB3 in cells impaired insulin-stimulated IRS1 and Akt phosphorylation, whereas TRB3KO mice displayed improved IRS1 and Akt phosphorylation. Finally, deletion of IRS1 abolished the function of TRB3 to regulate BAT differentiation and metabolism. These data demonstrate that TRB3 inhibits insulin signaling in BAT, resulting in impaired differentiation and function. - Highlights: • TRB3 is expressed in brown adipose tissue and its expression is increased during differentiation. • Overexpression of TRB3 inhibits differentiation and its activity. • Overexpression of TRB3 in brown preadipocytes inhibits insulin signaling. • TRB3KO mice displays improved insulin signaling in brown adipose tissue. • Insulin signaling is required for the effects of TRB3 to regulate brown adipose tissue differentiation and

  5. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling

    International Nuclear Information System (INIS)

    Jeong, Ha-Won; Choi, Ran Hee; McClellan, Jamie L.; Piroli, Gerardo G.; Frizzell, Norma; Tseng, Yu-Hua; Goodyear, Laurie J.; Koh, Ho-Jin

    2016-01-01

    Recent studies have demonstrated that adult humans have substantial amounts of functioning brown adipose tissue (BAT). Since BAT has been implicated as an anti-obese and anti-diabetic tissue, it is important to understand the signaling molecules that regulate BAT function. There has been a link between insulin signaling and BAT metabolism as deletion or pharmaceutical inhibition of insulin signaling impairs BAT differentiation and function. Tribbles 3 (TRB3) is a pseudo kinase that has been shown to regulate metabolism and insulin signaling in multiple tissues but the role of TRB3 in BAT has not been studied. In this study, we found that TRB3 expression was present in BAT and overexpression of TRB3 in brown preadipocytes impaired differentiation and decreased expression of BAT markers. Furthermore, TRB3 overexpression resulted in significantly lower oxygen consumption rates for basal and proton leakage, indicating decreased BAT activity. Based on previous studies showing that deletion or pharmaceutical inhibition of insulin signaling impairs BAT differentiation and function, we assessed insulin signaling in brown preadipocytes and BAT in vivo. Overexpression of TRB3 in cells impaired insulin-stimulated IRS1 and Akt phosphorylation, whereas TRB3KO mice displayed improved IRS1 and Akt phosphorylation. Finally, deletion of IRS1 abolished the function of TRB3 to regulate BAT differentiation and metabolism. These data demonstrate that TRB3 inhibits insulin signaling in BAT, resulting in impaired differentiation and function. - Highlights: • TRB3 is expressed in brown adipose tissue and its expression is increased during differentiation. • Overexpression of TRB3 inhibits differentiation and its activity. • Overexpression of TRB3 in brown preadipocytes inhibits insulin signaling. • TRB3KO mice displays improved insulin signaling in brown adipose tissue. • Insulin signaling is required for the effects of TRB3 to regulate brown adipose tissue differentiation and

  6. Genetics Home Reference: juvenile idiopathic arthritis

    Science.gov (United States)

    ... disease to fight microbial invaders and facilitate tissue repair. Normally, the body stops the inflammatory response after healing is complete to prevent damage to its own cells and tissues. In people with juvenile idiopathic arthritis , the inflammatory ...

  7. Seasonal Juvenile Salmonid Presence and Migratory Behavior in the Lower Columbia River

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Jessica A.; McMichael, Geoffrey A.; Welch, Ian D.; Harnish, Ryan A.; Bellgraph, Brian J.

    2009-04-30

    To facilitate preparing Biological Assessments of proposed channel maintenance projects, the Portland District of the U.S. Army Corps of Engineers contracted the Pacific Northwest National Laboratory to consolidate and synthesize available information about the use of the lower Columbia River and estuary by juvenile anadromous salmonids. The information to be synthesized included existing published documents as well as data from five years (2004-2008) of acoustic telemetry studies conducted in the Columbia River estuary using the Juvenile Salmon Acoustic Telemetry System. For this synthesis, the Columbia River estuary includes the section of the Columbia River from Bonneville Dam at river kilometer (Rkm) 235 downstream to the mouth where it enters the Pacific Ocean. In this report, we summarize the seasonal salmonid presence and migration patterns in the Columbia River estuary based on information from published studies as well as relevant data from acoustic telemetry studies conducted by NOAA Fisheries and the Pacific Northwest National Laboratory (PNNL) between 2004 and 2008. Recent acoustic telemetry studies, conducted using the Juvenile Salmon Acoustic Telemetry System (JSATS; developed by the Portland District of the U.S. Army Corps of Engineers), provided information on the migratory behavior of juvenile steelhead (O. mykiss) and Chinook salmon in the Columbia River from Bonneville Dam to the Pacific Ocean. In this report, Section 2 provides a summary of information from published literature on the seasonal presence and migratory behavior of juvenile salmonids in the Columbia River estuary and plume. Section 3 presents a detailed synthesis of juvenile Chinook salmon and steelhead migratory behavior based on use of the JSATS between 2004 and 2008. Section 4 provides a discussion of the information summarized in the report as well as information drawn from literature reviews on potential effects of channel maintenance activities to juvenile salmonids rearing in

  8. Autism spectrum disorder symptoms in juvenile suspects of sex offenses.

    Science.gov (United States)

    't Hart-Kerkhoffs, Lisette A; Jansen, Lucres M; Doreleijers, Theo A; Vermeiren, Robert; Minderaa, Ruud B; Hartman, Catharina A

    2009-02-01

    To investigate autism spectrum disorder (ASD) symptoms in juvenile suspects of sex offenses. A group of 175 juvenile suspected sex offenders (all males, mean +/- SD age = 14.9 +/- 1.4 years) was compared with a matched healthy control group (N = 500, mean +/- SD age = 14.0 +/- 1.4 years) and a group of children with DSM-IV-diagnosed ASD (N = 114, mean +/- SD age = 14.2 +/- 1.9 years) with respect to autistic symptoms as measured by means of a standardized questionnaire, the Children's Social Behavior Questionnaire. Furthermore, specific subgroups of sexual offenders, i.e., child molesters, solo peer offenders, and group offenders, were compared with regard to levels of ASD symptoms. The study was conducted from May 2003 to December 2006. Significantly higher levels of ASD symptoms were found in juvenile sex offenders than in healthy controls, while levels were lower than in the ASD group (F = 148.259, p symptoms than group offenders (F = 5.127, p symptoms are higher in juvenile suspects of sex offenses as compared to the healthy population, which argues for considering specific diagnostic assessment in this population, especially in solo offenders and child molesters. Copyright 2009 Physicians Postgraduate Press, Inc.

  9. Fitness Consequences of Boldness in Juvenile and Adult Largemouth Bass.

    Science.gov (United States)

    Ballew, Nicholas G; Mittelbach, Gary G; Scribner, Kim T

    2017-04-01

    To date, most studies investigating the relationship between personality traits and fitness have focused on a single measure of fitness (such as survival) at a specific life stage. However, many personality traits likely have multiple effects on fitness, potentially operating across different functional contexts and stages of development. Here, we address the fitness consequences of boldness, under seminatural conditions, across life stages and functional contexts in largemouth bass (Micropterus salmoides). Specifically, we report the effect of boldness on (1) juvenile survivorship in an outdoor pond containing natural prey and predators and (2) adult reproductive success in three outdoor ponds across three reproductive seasons (years). Juvenile survival was negatively affected by boldness, with bolder juveniles having a lower probability of survival than shyer juveniles. In contrast, bolder adult male bass had greater reproductive success than their shyer male counterparts. Female reproductive success was not affected by boldness. These findings demonstrate that boldness can affect fitness differently across life stages. Further, boldness was highly consistent across years and significantly heritable, which suggests that boldness has a genetic component. Thus, our results support theory suggesting that fitness trade-offs across life stages may contribute to the maintenance of personality variation within populations.

  10. Just Learning: The Imperative to Transform Juvenile Justice Systems into Effective Educational Systems. A Study of Juvenile Justice Schools in the South and the Nation. Special Summary

    Science.gov (United States)

    Southern Education Foundation, 2014

    2014-01-01

    This brief summarizes the findings of the larger study, "Just Learning: The Imperative to Transform Juvenile Justice Systems into Effective Educational Systems. A Study of Juvenile Justice Schools in the South and the Nation." With awareness growing that schools are disciplining and suspending minority students at alarming rates, the…

  11. Nailfold capillaroscopy in juvenile rheumatic diseases: known measures, patterns and indications.

    Science.gov (United States)

    Gerhold, K; Becker, M O

    2014-01-01

    Nailfold capillaroscopy has become an established method in adults for the evaluation of structural abnormalities of the microcirculation associated with rheumatic disease. It is a cornerstone for the diagnostic work-up of patients with Raynaud's phenomenon and the early diagnosis of systemic sclerosis. However, this non-invasive examination may also be valuable in children and adolescents with rheumatic diseases. Based on the scarce data available, this review focuses on capillaroscopic findings in healthy children and adolescents as well as in children with juvenile systemic sclerosis, juvenile dermatomyositis, juvenile idiopathic arthritis, and Raynaud's phenomenon. In addition, it outlines the potential benefits and limitations of nailfold capillaroscopy for routine care in paediatric rheumatology.

  12. Conservation implications of brown hyaena (Parahyaena brunnea population densities and distribution across landscapes in Botswana

    Directory of Open Access Journals (Sweden)

    Christiaan W. Winterbach

    2017-05-01

    Full Text Available The brown hyaena (Parahyaena brunnea is endemic to southern Africa. The largest population of this near-threatened species occurs in Botswana, but limited data were available to assess distribution and density. Our objectives were to use a stratified approach to collate available data and to collect more data to assess brown hyaena distribution and density across land uses in Botswana. We conducted surveys using track counts, camera traps and questionnaires and collated our results and available data to estimate the brown hyaena population based on the stratification of Botswana for large carnivores. Brown hyaenas occur over 533 050 km² (92% of Botswana. Our density estimates ranged from 0 brown hyaenas/100 km² in strata of northern Botswana to 2.94 (2.16–3.71 brown hyaenas/100 km² in the southern stratum of the Central Kalahari Game Reserve. We made assumptions regarding densities in strata that lacked data, using the best references available. We estimated the brown hyaena population in Botswana as 4642 (3133–5993 animals, with 6.8% of the population in the Northern Conservation Zone, 73.1% in the Southern Conservation Zone, 2.0% in the smaller conservation zones and 18.1% in the agricultural zones. The similar densities of brown hyaenas in the Central Kalahari Game Reserve and the Ghanzi farms highlight the potential of agricultural areas in Botswana to conserve this species. The conservation of brown hyaenas in the agricultural landscape of Botswana is critical for the long-term conservation of the species; these areas provide important links between populations in South Africa, Namibia and Zimbabwe. Conservation implications: Botswana contains the core of the brown hyaena population in southern Africa, and conflict mitigation on agricultural land is crucial to maintaining connectivity among the range countries.

  13. iTRAQ-Based Quantitative Proteomics Identifies Potential Regulatory Proteins Involved in Chicken Eggshell Brownness.

    Directory of Open Access Journals (Sweden)

    Guangqi Li

    Full Text Available Brown eggs are popular in many countries and consumers regard eggshell brownness as an important indicator of egg quality. However, the potential regulatory proteins and detailed molecular mechanisms regulating eggshell brownness have yet to be clearly defined. In the present study, we performed quantitative proteomics analysis with iTRAQ technology in the shell gland epithelium of hens laying dark and light brown eggs to investigate the candidate proteins and molecular mechanisms underlying variation in chicken eggshell brownness. The results indicated 147 differentially expressed proteins between these two groups, among which 65 and 82 proteins were significantly up-regulated in the light and dark groups, respectively. Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57 would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator, member 5 (SLC25A5 and down-regulated translocator protein (TSPO would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF. In other words, chickens from the light group produce less protoporphyrin IX, which is mainly used for heme synthesis. Therefore, the exported protoporphyrin IX available for eggshell deposition and brownness is reduced in the light group. The current study provides valuable information to elucidate variation of chicken eggshell brownness, and demonstrates the feasibility and sensitivity of iTRAQ-based quantitative proteomics analysis in providing useful insights into the molecular mechanisms underlying brown eggshell pigmentation.

  14. Pre-migratory differentiation of wild brown trout into migrant and resident individuals

    DEFF Research Database (Denmark)

    Nielsen, C.; Aarestrup, Kim; Norum, U.

    2003-01-01

    In February to March, wild brown trout Salmo trutta were captured by electrofishing in a natural watercourse (tributaries of the River Lille Aa, Denmark), individually tagged (Passive Integrated Transponders), and released. Representatives of the tagged brown trout were recaptured on the release......+,K+-ATPase analysis. Based on repetitive gill enzyme analysis in individual fish, a retrospective analysis of the rate of development in individual brown trout ultimately classified as migrants or residents was performed. Two months prior to migration, a bimodal morphological and physiological (gill Na...... a smolt-like appearance before the onset of migration and had higher rate of change of gill Na+,K+-ATPase activity than fish remaining residents. The rate of change of gill Na+,K+-ATPase activity was independent of the distance migrated to the trap (3-28 km). Thus in bimodal wild brown trout populations...

  15. Juvenile chronic arthritis into adulthood: a long-term follow-up study

    DEFF Research Database (Denmark)

    Zak, M; Pedersen, F K

    2000-01-01

    To evaluate a group of 65 adults with a history of or persistent juvenile chronic arthritis (JCA), on average, 26.4 yr after disease onset.......To evaluate a group of 65 adults with a history of or persistent juvenile chronic arthritis (JCA), on average, 26.4 yr after disease onset....

  16. A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis

    DEFF Research Database (Denmark)

    Ingegnoli, Francesca; Boracchi, Patrizia; Gualtierotti, Roberta

    2015-01-01

    OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus on capillar......OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus...... on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. RESULTS: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy...... in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. CONCLUSION: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern...

  17. Computed tomography of juvenile nasopharyngeal angiofibroma

    Energy Technology Data Exchange (ETDEWEB)

    Park, Cheong Hee; Yoo, Shi Joon; Lee, Yul; Chang, Kee Hyun; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1985-02-15

    It is well known that computed tomography (CT) is useful in detecting accurately the location, extent, erosion and relationship of angiofibroma to surrounding structures such as pterygopalation fossa. It is well known that computed tomography (CT) is useful in detecting accurately the location, sphenoid sinus, and etc. CT of 20 patients with juvenile angiofibroma, which were examined for 5 yeas from February, 1979 to May, 1984 at Department of Radiology, Seoul National University Hospital, were retrospectively analyzed. The results were as follows: 1. All 20 patients of juvenile angiofibroma had tumors in nasopharynx and posterior nasal cavity showing homogeneously dense-enhancing soft tissue mass on CT. There was extension of the tumor from nasopharynx and posterior nasal cavity into paranasal sinus (60%, 12/20), pterygopalatine fossa (55%, 11/20), infratemporal fossa (30%, 6/20), posterior orbit (10%, 2/20) and cranial cavity (15%, 3/20). 2. Angiogrpahy usually adds little diagnostic information, but is still needed to identify the precise source of blood supply to the tumor, and to perform the pre-operative embolization. The use of CT has deferred angiography until just before surgery, permitting embolization at optimal time. 3. CT is almost always necessary to reveal accurately the full extent of the tumor, especially intracranial space in the axial and coronal planes with contrast enhancement. CT is useful both in diagnosis as a guide to angiography and in planning the adequate therapy of juvenile angiofibroma.

  18. Influence of small hydropower plants on brown trout (Salmo trutta L. population in Mislinja River

    Directory of Open Access Journals (Sweden)

    Blaž Cokan

    2013-12-01

    Full Text Available The brown trout (Salmo trutta L. in the Mislinja River has been endangered for years because of small hydroelectric power plants. To find out how they are affecting the population of the brown trout in the Mislinja River, we conducted a sampling of the brown trout, using a generating set. We measured the length and weight of all caught specimens and analysed the obtained data. The results are presented in this paper, e.g., biomass, estimations of abundance, average weight, average length and number of captured brown trout. We discovered that the population of the brown trout has decreased in all the sections where water has been taken away for small hydroelectric power plants.

  19. JUVENILE SCLERODERMA-what has changed in the meantime?

    Science.gov (United States)

    Adrovic, Amra; Sahin, Sezgin; Barut, Kenan; Kasapcopur, Ozgur

    2018-04-22

    Juvenile scleroderma is a rarely seen chronic connective tissue disorder characterized by stiffening of the skin. The frequency of the disease was reported as one per million. According to organ involvement, the disease is divided into two main forms: systemic and localized scleroderma. Since it is uncommon in children, many aspects of the disease remain discussable. With this review, we aimed to revise recent findings and new developments in this rare condition. Skin manifestations are most prominent feature of the systemic form, followed by musculoskeletal and vascular involvement. Cardiovascular, gastrointestinal and renal disorders are rare in childhood. Combination of disease modifying antirheumatic drugs (methotrexate, mycophenolate-mofetil, cyclosporine) and steroid reprents the first line therapy. Bosentan is used for cases with pulmonary hypertension and for extensive digital ulcerations. Biological treatment emerges as a useful treatment option in most severe form of the disease. Localized scleroderma is characterized with sclerodermatosis of the skin. Internal organ involvement is not expected. Classification of the local scleroderma is made according to the size and localization of the skin changes. There are few different therapeutical options but there is no specific therapy for the localized scleroderma. Many data regarding disease features and treatment options in juvenile scleroderma are based on studies among adults. There is a striking need for multicentric, prospective studies among children with juvenile scleroderma.Emerging biological agents and new treatment options are showing promising results. Anyhow, juvenile scleroderma remains a mystery with many aspects of the disease waiting to be solved. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  20. A meta-analysis of the association between mental disorders and juvenile recidivism

    NARCIS (Netherlands)

    Wibbelink, C.J.M.; Hoeve, M.; Stams, G.J.J.M.; Oort, F.J.

    To investigate the association between mental disorders and recidivism in juveniles, a three-level meta-analysis of 20 manuscripts (17 independent studies, N = 5737 juveniles) was conducted. The study focused on internalizing disorders, externalizing disorders, and comorbid disorders (combinations