WorldWideScience

Sample records for just-so stories vaccines

  1. First Detailed Anatomical Study of Bonobos Reveals Intra-Specific Variations and Exposes Just-So Stories of Human Evolution, Bipedalism, and Tool Use

    Directory of Open Access Journals (Sweden)

    Rui Diogo

    2018-04-01

    Full Text Available Just-so stories are prominent in human evolution literature because of our tendency to create simple progressionist narratives about our “special” place in nature, despite the fact that these stories are almost exclusively based on hard tissue data. How can we be so certain about the evolution of human facial communication, bipedalism, tool use, or speech without detailed knowledge of the internal anatomy of for instance, one of the two extant species more closely related to us, the bonobos? Here I show how many of these stories now become obsolete, after such a comprehensive knowledge on the anatomy of bonobos and other primates is finally put together. Each and every muscle that has been long accepted to be “uniquely human” and to provide “crucial singular functional adaptations” for our bipedalism, tool use and/or vocal/facial communication, is actually present as an intra-specific variant or even as normal phenotype in bonobos and/or other apes.

  2. Personal Stories: Why Flu Vaccination Matters

    Centers for Disease Control (CDC) Podcasts

    2008-12-08

    In this podcast, moving personal stories help inform parents about the dangers of flu to children and the benefits of vaccination.  Created: 12/8/2008 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 12/8/2008.

  3. Just so stories: the random acts of anti-cancer nanomedicine performance.

    Science.gov (United States)

    Moghimi, Seyed Moein; Farhangrazi, Zahra Shadi

    2014-11-01

    Contrary to high expectations, the majority of clinically approved anti-cancer nanomedicine, and those under clinical trials, have shown limited therapeutic efficacy in humans. So, why these nanomedicine are not delivering their promise? Here, we discuss likely factors, and call for a paradigm shift in approach and design of future cancer nanotherapeutics based on realistic cancer models representing human disease, and better understanding of integrated pathophysiological processes, including systems immunology, that modulate human tumor functionality and growth. This critical review of the current state of translational oncology research utilizing nanomedicine-based approaches provides a comprehensive discussion of the multiple factors that are responsible for poor outcomes when translating these approaches models to the actual human disease.

  4. Hepatitis B Virus Vaccine: The Nigerian Story | Odusanya | Journal ...

    African Journals Online (AJOL)

    Hepatitis B (HBV) virus in endemic in Nigeria. Infection is acquired mainly in childhood through horizontal transmission. The infection is preventable by vaccination. Universal childhood vaccination against the infection started in Nigeria less than ten years. Hepatitis B vaccine coverage in Nigeria is 41%, though now it has ...

  5. Rotavirus Vaccines: a story of success with challenges ahead

    Science.gov (United States)

    O’Ryan, Miguel

    2017-01-01

    Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide. Currently, 92 countries have introduced rotavirus vaccines into national or subnational programs with evident impact in disease reduction. Two vaccines have been widely used, and four additional vaccines have been licensed and are being used in defined regions. In this context, one main issue that remains unsolved is the lower vaccine efficacy/effectiveness in low-income countries. An additional partially answered issue relates to rotavirus strain circulation in vaccinated populations. These issues are discussed in this review. The most imperative challenge ahead is to fulfill the WHO’s recommendation to introduce rotavirus vaccines in all countries. PMID:28928954

  6. The virus and the vaccine: the true story of a cancer-causing monkey virus, contaminated polio vaccine, and the millions of Americans exposed

    National Research Council Canada - National Science Library

    Bookchin, Debbie; Schumacher, Jim

    2004-01-01

    .... But now SV40 in showing up in human cancers, and prominent researchers are demanding a serious public health response to this forgotten polio vaccine contaminant. A gripping medical detective story, The Virus and the Vaccine raises major questions about vaccine policy.

  7. [Vaccines: history and stories between reality and imagination].

    Science.gov (United States)

    Terracciano, Elisa; Zorzoli, Ermanno; D'Alò, Gian Loreto; Zaratti, Laura; Franco, Elisabetta

    2016-01-01

    Vaccinations and the controversy around them always go in parallel. We identified four categories blending in various amounts of truth and imagination: history, myths, shams and frauds. Over the years, they have alternated and sometimes transformed into one another. This sharp separation into categories is certainly academic and forced. In fact, the line between these aspects is not clear enough to allow a rigid and well-defined division. Our work starts from the category containing the most truthfulness: history, and goes on to analyze two categories that add fantasy to facts: myths and shams (or better, "old wives' tales"). The history deals with the topics of variolation and the first anti-vaccine activists' disputes. Myths that arose around immunization include immune overload, homeoprophylaxis, and excessive hygiene. In this context, immunization itself risked becoming a myth, being considered not amenable to improvements. In the category of old wives' tales we find rumors about the presence in the vaccines of considerable quantities of supposedly toxic components such as aluminum, squalene, Thimerosal and nanoparticles, as well as the existence of secret techniques of vaccine preparation that involve unethical procedures. The last category, fraud, is the poorest in both truth and fantasy but it is still hard to confront. The most famous fraud is the supposed link between vaccines and autism. In this frame, disinformation is certainly a fertile substrate for the emergence both of elements close to reality and of very imaginative ones. Vaccine hesitancy is believed to be responsible for decreasing vaccine coverage and increasing the risk of vaccine-preventable disease outbreaks and epidemics. The role of communication in immunization is essential to its success, especially taking into account the deep transformations the world of information is going through. The great multitude of voices seem to carry the same weight, but it is not so in science. Web searches

  8. Examining Perceptions about Mandatory Influenza Vaccination of Healthcare Workers through Online Comments on News Stories.

    Directory of Open Access Journals (Sweden)

    Yang Lei

    Full Text Available The aim of this study was to understand online public perceptions of the debate surrounding the choice of annual influenza vaccinations or wearing masks as a condition of employment for healthcare workers, such as the one enacted in British Columbia in August 2012.Four national and 82 local (British Columbia Canadian online news sites were searched for articles posted between August 2012 and May 2013 containing the words "healthcare workers" and "mandatory influenza vaccinations/immunizations" or "mandatory flu shots and healthcare workers." We included articles from sources that predominantly concerned our topic of interest and that generated reader comments. Two researchers coded the unedited comments using thematic analysis, categorizing codes to allow themes to emerge. In addition to themes, the comments were categorized by: 1 sentiment towards influenza vaccines; 2 support for mandatory vaccination policies; 3 citing of reference materials or statistics; 4 self-identified health-care worker status; and 5 sharing of a personal story.1163 comments made by 648 commenters responding to 36 articles were analyzed. Popular themes included concerns about freedom of choice, vaccine effectiveness, patient safety, and distrust in government, public health, and the pharmaceutical industry. Almost half (48% of commenters expressed a negative sentiment toward the influenza vaccine, 28% were positive, 20% were neutral, and 4% expressed mixed sentiment. Of those who commented on the policy, 75% did not support the condition to work policy, while 25% were in favour. Of the commenters, 11% self-identified as healthcare workers, 13% shared personal stories, and 18% cited a reference or statistic.The perception of the influenza vaccine in the comment sections of online news sites is fairly poor. Public health agencies should consider including online forums, comment sections, and social media sites as part of their communication channels to correct

  9. Rotavirus Vaccines: a story of success with challenges ahead [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Miguel O’Ryan

    2017-08-01

    Full Text Available Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide. Currently, 92 countries have introduced rotavirus vaccines into national or subnational programs with evident impact in disease reduction. Two vaccines have been widely used, and four additional vaccines have been licensed and are being used in defined regions. In this context, one main issue that remains unsolved is the lower vaccine efficacy/effectiveness in low-income countries. An additional partially answered issue relates to rotavirus strain circulation in vaccinated populations. These issues are discussed in this review. The most imperative challenge ahead is to fulfill the WHO’s recommendation to introduce rotavirus vaccines in all countries.

  10. "Mommy Blogs" and the Vaccination Exemption Narrative: Results From A Machine-Learning Approach for Story Aggregation on Parenting Social Media Sites.

    Science.gov (United States)

    Tangherlini, Timothy R; Roychowdhury, Vwani; Glenn, Beth; Crespi, Catherine M; Bandari, Roja; Wadia, Akshay; Falahi, Misagh; Ebrahimzadeh, Ehsan; Bastani, Roshan

    2016-11-22

    Social media offer an unprecedented opportunity to explore how people talk about health care at a very large scale. Numerous studies have shown the importance of websites with user forums for people seeking information related to health. Parents turn to some of these sites, colloquially referred to as "mommy blogs," to share concerns about children's health care, including vaccination. Although substantial work has considered the role of social media, particularly Twitter, in discussions of vaccination and other health care-related issues, there has been little work on describing the underlying structure of these discussions and the role of persuasive storytelling, particularly on sites with no limits on post length. Understanding the role of persuasive storytelling at Internet scale provides useful insight into how people discuss vaccinations, including exemption-seeking behavior, which has been tied to a recent diminution of herd immunity in some communities. To develop an automated and scalable machine-learning method for story aggregation on social media sites dedicated to discussions of parenting. We wanted to discover the aggregate narrative frameworks to which individuals, through their exchange of experiences and commentary, contribute over time in a particular topic domain. We also wanted to characterize temporal trends in these narrative frameworks on the sites over the study period. To ensure that our data capture long-term discussions and not short-term reactions to recent events, we developed a dataset of 1.99 million posts contributed by 40,056 users and viewed 20.12 million times indexed from 2 parenting sites over a period of 105 months. Using probabilistic methods, we determined the topics of discussion on these parenting sites. We developed a generative statistical-mechanical narrative model to automatically extract the underlying stories and story fragments from millions of posts. We aggregated the stories into an overarching narrative framework

  11. 'I was just so different': The experiences of women diagnosed with an autism spectrum disorder in adulthood in relation to gender and social relationships.

    Science.gov (United States)

    Kanfiszer, Lucie; Davies, Fran; Collins, Suzanne

    2017-08-01

    Existing literature exploring autism spectrum disorders within female populations predominantly utilises quantitative methodology. A limited number of small-scale, qualitative studies have explored the experiences of adolescent girls with autism spectrum disorder, but adult women have remained largely unheard. This study aims to broaden the stories told within autobiographical literature and empower those within the wider community of women with autism spectrum disorder. In doing so, it seeks to extend existing conceptualisations of experience to include socially and culturally located factors. A qualitative methodology was adopted, utilising multi-stage narrative analysis. Seven semi-structured interviews with women who received a diagnosis in adulthood were conducted. Recruitment spanned community mental health services, an inpatient service and a community support group. From the women's diverse experiences and stories emerged two broad categories related to gender identity and social relationships. The findings are discussed in relation to existing constructs of autism in women.

  12. [VACCINES].

    Science.gov (United States)

    Bellver Capella, Vincente

    2015-10-01

    Vaccines are an extraordinary instrument of immunization of the population against infectious diseases. Around them there are many ethical issues. One of the most debated is what to do with certain groups opposition to vaccination of their children. States have managed in different ways the conflict between the duty of vaccination and the refusal to use vaccines: some impose the vaccination and others simply promote it. In this article we deal with which of these two approaches is the most suitable from an ethical and legal point of view. We stand up for the second option, which is the current one in Spain, and we propose some measures which should be kept in mind to improve immunization programs.

  13. If war is "just," so is abortion.

    Science.gov (United States)

    Kissling, F

    1991-01-01

    Currently Catholic bishops are applying an inconsistent ethical paradigm to the issues of war and abortion. Based on the seamless garment theory war, abortion and capital punishment are all immoral acts because they are of the same garment. They are all "killing acts" and as such they are immoral. However there is within the Catholic paradigm the idea of a just war. The just war theory states that the destruction of human life in war is justified if it is for a greater good. However abortion has no exceptions, there is no just abortion in the rules of the Catholic Church. The author takes the just war doctrine as presented by the Catholic Church and shows how it could easily apply to abortion. Both war and abortion involve the taking of a human life, but in the case of war the taking of a life is justified if it is done to protect your own life. The same exception in abortion would be to allow abortion when the mother's life is in danger. yet no such exception exists. The just war theory further states that was is necessary to protect national integrity, particularly if the violation erodes the quality of life for its citizens. The same exception for abortion would include allowing abortions for women who already have more children then they can care for or if having the child would erode the quality of life for the woman. Other aspects of the just war theory include the competence and goals of the national leaders. Women must also be allowed to be competent moral agents. Proponents of the seamless garment theory will bring up the fact that in a just war only combatants die yet the fetus is innocent. But no war has ever been fought without the loss of innocent civilians.

  14. Community Immunity: How Vaccines Protect Us All

    Science.gov (United States)

    ... child’s doctor if you have any concerns about vaccine safety. Related Stories Unexplained Cases of Allergic Reactions Linked to Red Meat Reducing Children’s Chances of Asthma Flu Vaccine Skin Patch Tested ...

  15. Culture Stories

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2007-01-01

    This paper argues for a narrative approach to the study of urban branding and planning. An analytical framework for understanding narratives and place is presented. The notion of the ‘representational logics of urban intervention' captures this idea that urban branding interventions are guided by...... competing stories are told by proponents and opponents of the interventions. The relation to place in the stories differ radically for those favour and those against, and the paper aims throwing light over the complex relationship between story and place....

  16. Theoretical Stories

    Directory of Open Access Journals (Sweden)

    Tanya Serisier

    2012-03-01

    Full Text Available A review of Clare Hemmings, Why Stories Matter: The Political Grammar of Feminist Theory (Duke 2011 and Janet Halley & Andrew Parker (eds. After Sex? On Writing Since Queer Theory (Duke 2011.

  17. Data Stories

    DEFF Research Database (Denmark)

    Watts, Laura; Nafus, Dawn

    2013-01-01

    ‘Big Data’ rises and accumulates today from so much of our activity, off and online, that our lives seem almost suffused by ‘The Cloud’. But perhaps data might be otherwise? In this collection, Laura Watts and Dawn Nafus, two ethnographers, bring together stories from different data sites: from...... the marine energy industry, and from the Quantified Self movement. These Data Stories speak, not of clouds, but of transformations: in things, in energy, and in experience....

  18. Atoms stories

    International Nuclear Information System (INIS)

    Radvanyi, P.; Bordry, M.

    1988-01-01

    Physicists from different countries told each evening during one learning week, to an audience of young people, some great discoveries in evoking the difficulties and problems to which the researchers were confronted. From Antiquity to a more recent history, it is a succession of atoms stories. (N.C.)

  19. Toy Story

    DEFF Research Database (Denmark)

    Cole, Anne Jodon; Petersson Brooks, Eva

    2016-01-01

    a mediating device between adults and children. The question then becomes, how does a display of static toys speak to a child’s culture of play? Through interviews with toy museum curators and personal observations it was found that the exhibition was designed to have adults share and reflect stories about...

  20. Silly Stories

    Science.gov (United States)

    Reading Teacher, 2011

    2011-01-01

    There are many different kinds of words in the English language. Instruction in grammar and syntax helps young writers sort out when to use a plural or singular noun, or when to use an apostrophe. Silly Stories, a variation of a popular party game, reinforces the importance of word choice and conventions in writing. This article describes a…

  1. Another vaccine, another story: BCG vaccination against tuberculosis in India, 1948 to 1960 Outra vacina, outra história: a vacinação de BCG contra tuberculose na Índia, 1948 a 1960

    Directory of Open Access Journals (Sweden)

    Niels Brimnes

    2011-02-01

    Full Text Available Through an examination of mass BCG vaccination against tuberculosis in India between 1948 and 1960 this article draws attention to the diversity of the history of vaccination. The features of vaccination campaigns often differed from those of the celebrated campaign to eradicate smallpox. Due to differences between smallpox and tuberculosis as well as between the vaccines developed against them, an analysis of BCG mass vaccination against tuberculosis seems particularly well suited for this purpose. Three points of difference are identified. First, in non-Western contexts BCG vaccination procedures were modified to a greater extent than vaccination against smallpox. Second, tuberculosis lacked the drama and urgency of smallpox and BCG vaccination campaigns suffered more from recruitment problems than did the more "heroic" smallpox eradication campaign. Third, the BCG vaccine was contested in medical circles and was much better suited than the vaccine against smallpox as a vehicle for the articulation of concerns about post-colonial modernization.Através da observação da vacinação em massa de BCG contra a tuberculose na Índia durante os anos de 1948 a 1960, este artigo chama a atenção para a diversidade da história da vacinação. As características das campanhas de vacinação geralmente diferem daquelas celebradas nas campanhas para erradicação da varíola. Devido às diferenças entre a varíola e a turberculose, assim como entre as vacinas desenvolvidas para combater essas doenças, uma análise da vacinação em massa de BCG contra a turberculose parece especialmente bem situada para essa proposta. Três pontos de diferença foram identificados. O primeiro é que em contextos não ocidentais os procedimentos da vacinação de BCG foram modificados em uma extensão maior do que a vacinação contra a varíola. Em segundo lugar, a tuberculose não tinha o drama e a urgência da varíola, e as campanhas de vacinação de BCG

  2. Policy stories

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Rasmussen, Rasmus Kjærgaard

    This article uses Arctic Winter 2016 as an exploration site of values and futures in Greenland. By taking a valuation approach where the creation and interpretation of event values are seen as an ongoing and taxing accomplishment, we firstly expand the understanding of events beyond their actual...... present three central policy stories from the field. The stories tell of how the event was first interested, then activated and finally evaluated. Besides adding a new understanding to policy-driven events as a locus of value creation, we also argue that the AWG 2016 offer speculative bets for new...... planning and execution and of event outcomes beyond the narrow confines of bed nights and legacies. Second, we introduce policies as an entry point to unlock discussions and manifestations of value and futures which connect to AWG. In order to exemplify the workings of the AWG event in these domains, we...

  3. Life Stories and Trauma

    DEFF Research Database (Denmark)

    Kongshøj, Inge Lise Lundsgaard; Bohn, Annette; Berntsen, Dorthe

    Research has shown a connection between Posttraumatic Stress Disorder (PTSD) and integration of traumatic experiences into the life story. Furthermore, empirical evidence suggests that life story formation begins in mid to late adolescence. Following these findings, the present study investigated...... whether experiencing trauma in youth was associated with a greater risk to integrate the trauma into the life story compared to adult traumatic exposure. Life stories were collected from 115 participants recruited via Amazon Mechanical Turk. Moreover, participants filled out questionnaires regarding...... often integrate the trauma into their life story? Results will be discussed in relation to theories of development of life stories and of PTSD....

  4. When's a story not at story?

    DEFF Research Database (Denmark)

    Christensen, Eva

    . For example, as presented in this paper, a tourist guide tells the same story about a violent motorcycle gang, part of her ancetdotal reportoire, during two guided tours. The story is fixed in content and structure, but when brought into social interaction with tourists, it becomes part of a broader narrative...

  5. Story quality management

    International Nuclear Information System (INIS)

    1976-12-01

    This book is written to explain quality management using stories, which have each story about quality management. The titles of stories are way to tell the meaning in mind, mom, house wife's meal costs a great deal, good bye digestive medicine, beans cooked in soy sauce, wedding and space rocket, each story is used to give descriptions of quality management like procedure and decision for division of labor, quality guaranteed and histogram.

  6. Fragmented Work Stories

    DEFF Research Database (Denmark)

    Humle, Didde Maria; Reff Pedersen, Anne

    2015-01-01

    stories. We argue that meaning by story making is not always created by coherence and causality; meaning is created by different types of fragmentation: discontinuities, tensions and editing. The objective of this article is to develop and advance antenarrative practice analysis of work stories...

  7. Vaccination against measles: a neverending story.

    NARCIS (Netherlands)

    K.J. Stittelaar (Koert); R.L. de Swart (Rik); A.D.M.E. Osterhaus (Albert)

    2002-01-01

    textabstractMeasles, a highly contagious viral disease, is a major childhood killer in developing countries, accounting for almost 1 million deaths every year globally. Measles virus normally does not cause a persistent infection, no animal reservoir for measles virus exists, no vector is involved

  8. Designing a story database for use in automatic story generation

    NARCIS (Netherlands)

    Oinonen, Katri; Theune, Mariët; Nijholt, Anton; Uijlings, Jasper; Harper, Richard; Rauterberg, Matthias; Combetto, Marco

    In this paper we propose a model for the representation of stories in a story database. The use of such a database will enable computational story generation systems to learn from previous stories and associated user feedback, in order to create believable stories with dramatic plots that invoke an

  9. Vaccination: An Act of Love

    Science.gov (United States)

    ... GET A BIG SHOT! IT'S JUST A TINY ONE! IT DOESN'T HURT! LET ME TELL YOU A STORY, JIMMY FIVE! 6 ” FOR YOU TO GROW AND BE STRONG, YOU HAFTA BE HEALTHY, RIGHT?” AND THE VACCINE WILL PREVENT LOTS OF DISEASES ...

  10. My Story: Real Stories of People Living with Thalassemia

    Science.gov (United States)

    ... Share Compartir Real Stories from People living with Thalassemia On this Page Rahul’s Story Aaron’s Story Rahul’s ... is Rahul Kapoor, and I was born with thalassemia, a blood disorder which requires transfusions every other ...

  11. Vaccines (immunizations) - overview

    Science.gov (United States)

    Vaccinations; Immunizations; Immunize; Vaccine shots; Prevention - vaccine ... of the vaccine. VACCINE SCHEDULE The recommended vaccination (immunization) schedule is updated every 12 months by the ...

  12. Everybody Has a Story

    DEFF Research Database (Denmark)

    The book bears witness of Young peoples lived lives across Europe, Russia and Japan. It contains stories about love, loss of love and loss of loved ones, about dreams of future lives and wonders of lives as such. And it tells stories about bullying, mental illness and simple strives just to be able...

  13. The Story of Women

    Science.gov (United States)

    Grady, Marilyn L.

    2008-01-01

    In this article, the author shares Elizabeth Ann Seton's story as a woman's story. Seton was born in 1774 to a New York family. Through her work in Maryland, Seton was credited with being the founder of the parochial Catholic school system in the U.S. Seton formed a group of sisters known as the Sisters of Charity of St. Joseph. The sisters…

  14. StoryTrek

    DEFF Research Database (Denmark)

    Khaled, Rilla; Barr, Pippin; Greenspan, Brian

    2010-01-01

    Narrative is an important aspect of persuasion, but persua- sive technologies often use narrative in its most traditional, linear form. We present StoryTrek, a prototype system which creates narratives based on a reader’s location and movements in the real world. StoryTrek yields a number of unique...

  15. Bringing the Story Alive

    Science.gov (United States)

    Dunne, Ian B.

    2006-01-01

    Science is a story, a narrative, and scientists are storytellers. Teaching is quite possibly the ultimate in storytelling so if one is teaching science he/she is already storytelling. Using a story to set up a science topic is effective. One can engage the brains of the audience, paint the scene, let them realise why the idea or work is important…

  16. Understanding vaccines: a public imperative.

    Science.gov (United States)

    Federman, Ross S

    2014-12-01

    Though once a discovery greatly celebrated by the nation, the vaccine has come under fire in recent decades from skeptics, critics, and a movement set into motion by fraudulent scientists and fueled by frustrated parents looking for answers to the autism conundrum. There is enough denialist resistance to vaccination to bring upon renewed fear of young children and infants becoming infected with diseases, the threats of which had been functionally eradicated from the United States. In more recent years, the surge in independent online journalism and blogging has invited many to rapidly share their opinions with millions of readers and, importantly, has appeared to open the door for opinion to be portrayed as fact. As a result, many parents are inundated with horror stories of vaccine dangers, all designed to eat away at them emotionally while the medical and scientific communities have mounted their characteristic response by sharing the facts, the data, and all of the reliable peer-reviewed and well-cited research to show that vaccines are safe and effective. It has become clear to me that facts are no match for emotion, but perhaps an understanding behind vaccine methodology will help parents overcome these fears of vaccinating. By helping those who doubt vaccines better understand what vaccines really are and how they work in such an incredibly engineered fashion, we may have a stronger weapon than we realize in battling the emotional arsenal that comes from the fear and skepticism of vaccinating.

  17. Stories on the go

    DEFF Research Database (Denmark)

    Madsen, Karen Hvidtfeldt

    2014-01-01

    The article focuses on 1001 Stories of Denmark: an internet site and a mobile app that collects and displays stories and visual material connected to places all over Denmark. This site offers a “social media-like” communication frame with various levels of participation. But in reality, 1001...... and affective narratives. I argue that these videos and stories demonstrate the potential of mobile and digital cultural heritage sites; however, it requires strategic initiatives and long-term engagement from museums and cultural institutions to create and maintain the level of the dialogue and participation....

  18. Green revolution vaccines, edible vaccines

    African Journals Online (AJOL)

    Admin

    of development. Food vaccines may also help to suppress autoimmunity disorders such as Type-1. Diabetes. Key words: Edible vaccines, oral vaccines, antigen expression, food vaccines. INTRODUCTION. Vaccination involves the stimulation of the immune system to prepare it for the event of an invasion from a particular ...

  19. ACTS – SUCCESS STORY

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. ACTS – SUCCESS STORY. Totally 103 experiments were conducted and the programme succeeded in the areas. Medicine; Education; Defence; Emergency Response; Maritime and Aeronautical Mobile Communications; Science and Astronomy.

  20. Researcher Story: Stuttering

    Science.gov (United States)

    ... Have a Question In the News Researcher Story: Stuttering In a 2010 movie, The King’s Speech, many ... effects of the disorder. How Do Researchers Study Stuttering? Video of How Do Researchers Study Stuttering? A ...

  1. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... Have a Question In the News Researcher Story: Stuttering In a 2010 movie, The King’s Speech, many ... effects of the disorder. How Do Researchers Study Stuttering? Video of How Do Researchers Study Stuttering? A ...

  2. Telling Teaching Stories.

    Science.gov (United States)

    Gomez, Mary Louise; Tabachnick, B. Robert

    1992-01-01

    Telling teaching stories assists prospective teachers in becoming effective teachers of elementary school children. It offers preservice teachers and teacher educators the challenge of seeing themselves and the opportunity to reflect on their goals and practices. (IAH)

  3. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... You Talking to Your Doctor Science Education Resources Community Resources Clear Health A–Z Publications List More » ... Personal Stories For Parents and Children For Health Care Providers For Researchers and Trial Sites Educational Resources ...

  4. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... Registries Personal Stories For Parents and Children For Health Care ... known as stuttering and about the King’s work with a speech therapist to overcome this communication ...

  5. Story of Fluoridation

    Science.gov (United States)

    ... Home Health Info Health Topics Fluoride Share The Story of Fluoridation It started as an observation, that ... this time using photospectrographic analysis, a more sophisticated technology than that used by McKay. Churchill asked an ...

  6. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... If You Have a Question In the News Researcher Story: Stuttering In a 2010 movie, The King’s ... mitigate the effects of the disorder. How Do Researchers Study Stuttering? Video of How Do Researchers Study ...

  7. Vaccine Safety

    Science.gov (United States)

    ... During Pregnancy Frequently Asked Questions about Vaccine Recalls Historical Vaccine Safety Concerns FAQs about GBS and Menactra ... CISA Resources for Healthcare Professionals Evaluation Current Studies Historical Background 2001-12 Publications Technical Reports Vaccine Safety ...

  8. Building our stories

    DEFF Research Database (Denmark)

    Tourism transforms people and places. New stakeholders are emerging, landscapes of power are shifting, and lines of responsibilities are being redrawn. Everyday stories of coping, success, empowerment, nurturing, relationship building and activism are important tools for reflection and learning...... for our first TEFI regional conference. Storytelling is a powerful way of exploring, linking and crafting values, articulating them is such a way as to instil action. This conference proceedings assembles 31research stories of sustainable, caring and ethical worldmaking in tourism....

  9. Teddy Bear Stories

    DEFF Research Database (Denmark)

    van Leeuwen, Theo; Caldas-Coulthardt, Carmen

    2014-01-01

    This paper presents a semiotic analysis of a key cultural artefact, the teddy bear. After introducing the iconography of the teddy bear, it analyses different kinds of stories to show how teddy bears are endowed with meaning in everyday life: stories from children's books, reminiscenses by adults...... bears have traditionally centred on interpersonal relations within the nuclear family, but have recently been institutionalized and commercialized....

  10. Vaccines.gov

    Science.gov (United States)

    ... Vaccine Safety Vaccines Work Vaccine Types Vaccine Ingredients Vaccines by Disease Chickenpox ... Typhoid Fever Whooping Cough (Pertussis) Yellow Fever Who and When Infants, Children, and Teens ...

  11. Rotavirus vaccines

    Directory of Open Access Journals (Sweden)

    Kang G

    2006-01-01

    Full Text Available Rotavirus, the most common cause of severe diarrhea and a leading cause of mortality in children, has been a priority target for vaccine development for the past several years. The first rotavirus vaccine licensed in the United States was withdrawn because of an association of the vaccine with intussusception. However, the need for a vaccine is greatest in the developing world, because the benefits of preventing deaths due to rotavirus disease are substantially greater than the risk of intussusception. Early vaccines were based on animal strains. More recently developed and licenced vaccines are either animal-human reassortants or are based on human strains. In India, two candidate vaccines are in the development process, but have not yet reached efficacy trials. Many challenges regarding vaccine efficacy and safety remain. In addition to completing clinical evaluations of vaccines in development in settings with the highest disease burden and virus diversity, there is also a need to consider alternative vaccine development strategies.

  12. Hepatitis Vaccines

    OpenAIRE

    Ogholikhan, Sina; Schwarz, Kathleen B.

    2016-01-01

    Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B ...

  13. Story Development in Cinematography

    OpenAIRE

    Anderson, L

    2011-01-01

    First off, I’ve got to argue for the use of the word “cinematography” over “camera”. One is to utilize a word I would like to further unpack. Another is to utilize a word that simply implies a relationship to another art form entirely – photography. I often say to my students that some cinematographers initially come from the lighting point of view and some come from the camera, but ultimately what great cinematographers do is understand a story (not just a moment that tells a story – there i...

  14. Recension: Mao - The Unknown Story

    DEFF Research Database (Denmark)

    Clausen, Søren

    2005-01-01

    Anmeldelse - kritisk! - til Sveriges førende Kinatidsskrift af Jung Chang & Jon Halliday's sensationelle "Mao - the Unknown Story".......Anmeldelse - kritisk! - til Sveriges førende Kinatidsskrift af Jung Chang & Jon Halliday's sensationelle "Mao - the Unknown Story"....

  15. Rotavirus vaccines

    Science.gov (United States)

    Yen, Catherine; Tate, Jacqueline E; Hyde, Terri B; Cortese, Margaret M; Lopman, Benjamin A; Jiang, Baoming; Glass, Roger I; Parashar, Umesh D

    2014-01-01

    Rotavirus is the leading cause of severe diarrhea among children rotavirus vaccines have been efficacious and effective, with many countries reporting substantial declines in diarrheal and rotavirus-specific morbidity and mortality. However, the full public health impact of these vaccines has not been realized. Most countries, including those with the highest disease burden, have not yet introduced rotavirus vaccines into their national immunization programs. Research activities that may help inform vaccine introduction decisions include (1) establishing effectiveness, impact, and safety for rotavirus vaccines in low-income settings; (2) identifying potential strategies to improve performance of oral rotavirus vaccines in developing countries, such as zinc supplementation; and (3) pursuing alternate approaches to oral vaccines, such as parenteral immunization. Policy- and program-level barriers, such as financial implications of new vaccine introductions, should be addressed to ensure that countries are able to make informed decisions regarding rotavirus vaccine introduction. PMID:24755452

  16. Storytelling? Everyone Has a Story

    Science.gov (United States)

    Keller, Cynthia

    2012-01-01

    School librarians can assume an important role in preserving and perpetuating the oral tradition. The same skills and techniques when telling a personal story can be transmitted to telling various kinds of stories from literature and history. For school librarians to be successful storytellers, they need to select stories that they like and enjoy…

  17. Writing Stories in the Sciences

    Science.gov (United States)

    Lee, Eunbae; Maerz, John C.

    2015-01-01

    Writing stories is advocated as an excellent means of learning the process of science; however, little is understood about students' experiences of engaging in story writing in postsecondary science courses. The study described in this article was designed to improve the practice of using stories in science by examining students' lived experience…

  18. Children Writing Stories

    Science.gov (United States)

    Armstrong, Michael

    2006-01-01

    In this book, the author reveals the creative force of children's narrative imagination and shows how this develops through childhood. He provides a new and powerful understanding of the significance of narrative for children's intellectual growth and for learning and teaching. The book explores a series of real stories written by children between…

  19. New Suburban Stories

    NARCIS (Netherlands)

    Dines, M.; Vermeulen, T.J.V.

    2013-01-01

    Exploring fiction, film and art from across the USA, South America, Asia, Europe and Australia, New Suburban Stories brings together new research from leading international scholars to examine cultural representations of the suburbs, home to a rapidly increasing proportion of the world's population.

  20. Teaching Science through Story

    Science.gov (United States)

    Horton, Jessica

    2013-01-01

    Children find comfort in stories. They are familiar, accessible and entertaining. By teaching science through narratives, we can provide that same comfort and access to scientific content to children of all ages. In this article, I will discuss how, through the use of narratives in science instruction, we can provide students with a deeper…

  1. Elizabeth Belle's Birth Story.

    Science.gov (United States)

    Boro, Jessica; Boro, Samuel

    2014-01-01

    In this article, Jessica and Samuel Boro share the story of the birth of their daughter, Elizabeth Belle. With the physical and emotional support of her husband and her doula, this mother was able to cope with a long labor and have the natural birth she wanted. Her husband describes how important the doula was for him.

  2. Gamers Telling Stories

    DEFF Research Database (Denmark)

    Albrechtslund, Anne-Mette Bech

    2010-01-01

    of Warcraft , make sense of their gaming experience, and how they build and uphold a community identity by telling stories online. I argue that in studying and conceptualizing these types of texts through the proposed theoretical framework, we can gain insights into the process of the formation of meaning...

  3. When do Stories Work?

    DEFF Research Database (Denmark)

    Gelman, Andrew; Basbøll, Thomas

    2014-01-01

    Storytelling has long been recognized as central to human cognition and communication. Here we explore a more active role of stories in social science research, not merely to illustrate concepts but also to develop new ideas and evaluate hypotheses, for example, in deciding that a research method...

  4. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... You Have a Question In the News Researcher Story: Stuttering In a 2010 movie, The King’s Speech, ... from NIH Footer NIH Home En Español Site Map Visitor Information Frequently Asked Questions Web Policies and ...

  5. Beyond the Single Story

    Science.gov (United States)

    McKenney, Yekaterina

    2016-01-01

    Teachers of world literature have the opportunity to help students explore the more complex reality behind the stereotypes that they often see in the media. If we don't encourage students to challenge one-dimensional "single stories" that characterize an entire people--whether Muslims, Russians, Mexicans, African Americans, Chinese,…

  6. The Story of Iyal

    Centers for Disease Control (CDC) Podcasts

    2009-08-24

    In this podcast, a mother tells her compelling story about a family living with fetal alcohol spectrum disorders.  Created: 8/24/2009 by National Center on Birth Defects and Developmental Disabilities (NCBDDD).   Date Released: 8/24/2009.

  7. Vaccine Hesitancy.

    Science.gov (United States)

    Jacobson, Robert M; St Sauver, Jennifer L; Finney Rutten, Lila J

    2015-11-01

    Vaccine refusal received a lot of press with the 2015 Disneyland measles outbreak, but vaccine refusal is only a fraction of a much larger problem of vaccine delay and hesitancy. Opposition to vaccination dates back to the 1800 s, Edward Jenner, and the first vaccine ever. It has never gone away despite the public's growing scientific sophistication. A variety of factors contribute to modern vaccine hesitancy, including the layperson's heuristic thinking when it comes to balancing risks and benefits as well as a number of other features of vaccination, including falling victim to its own success. Vaccine hesitancy is pervasive, affecting a quarter to a third of US parents. Clinicians report that they routinely receive requests to delay vaccines and that they routinely acquiesce. Vaccine rates vary by state and locale and by specific vaccine, and vaccine hesitancy results in personal risk and in the failure to achieve or sustain herd immunity to protect others who have contraindications to the vaccine or fail to generate immunity to the vaccine. Clinicians should adopt a variety of practices to combat vaccine hesitancy, including a variety of population health management approaches that go beyond the usual call to educate patients, clinicians, and the public. Strategies include using every visit to vaccinate, the creation of standing orders or nursing protocols to provide vaccination without clinical encounters, and adopting the practice of stating clear recommendations. Up-to-date, trusted resources exist to support clinicians' efforts in adopting these approaches to reduce vaccine hesitancy and its impact. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  8. Core story creation: analysing narratives to construct stories for learning.

    Science.gov (United States)

    Petty, Julia; Jarvis, Joy; Thomas, Rebecca

    2018-03-16

    Educational research uses narrative enquiry to gain and interpret people's experiences. Narrative analysis is used to organise and make sense of acquired narrative. 'Core story creation' is a way of managing raw data obtained from narrative interviews to construct stories for learning. To explain how core story creation can be used to construct stories from raw narratives obtained by interviewing parents about their neonatal experiences and then use these stories to educate learners. Core story creation involves reconfiguration of raw narratives. Reconfiguration includes listening to and rereading transcribed narratives, identifying elements of 'emplotment' and reordering these to form a constructed story. Thematic analysis is then performed on the story to draw out learning themes informed by the participants. Core story creation using emplotment is a strategy of narrative reconfiguration that produces stories which can be used to develop resources relating to person-centred education about the patient experience. Stories constructed from raw narratives in the context of constructivism can provide a medium or an 'end product' for use in learning resource development. This can then contribute to educating students or health professionals about patients' experiences. ©2018 RCN Publishing Company Ltd. All rights reserved. Not to be copied, transmitted or recorded in any way, in whole or part, without prior permission of the publishers.

  9. DHEC: Vaccinations

    Science.gov (United States)

    Data, Maps - SC Public Health Diseases and Conditions Flu Tuberculosis STD/HIV and Viral Hepatitis Zika Illnesses E. coli Listeriosis Salmonella Hepatitis A Shellfish Monitoring and Regulation Certified Shippers Vaccines Teen and Preteen Vaccines Vaccines Needed for School Admission Related Topics Perinatal Hepatitis

  10. Intercultural Collaboration Stories

    DEFF Research Database (Denmark)

    Gertsen, Martine Cardel; Søderberg, Anne-Marie

    2011-01-01

    The objective of this article is to show how narrative methods provide useful tools for international business research. We do this by presenting a study of stories told about the collaboration between a Danish expatriate manager and his Chinese CEO in the Shanghai subsidiary of an MNE. First, we...... to elucidate intercultural collaboration processes by analyzing how each member of a dyad of interacting managers narrates the same chain of events. We show how the narratological concepts of peripeteia and anagnorisis are well suited to identifying focal points in their stories: situations where change...... follows their recognizing new dimensions of their conflicts, eventually furthering their collaboration. We explain how Greimas's actantial model is valuable when mapping differences between and changes in the narrators’ projects, alliances and oppositions in the course of their interaction. Thus, we make...

  11. Storie di genere, storie di partito

    Directory of Open Access Journals (Sweden)

    Elisa Bellè

    2012-04-01

    Full Text Available Lo studio delle narrazioni di genere all'interno di questo tipo di organizzazione desta inoltre un particolare interesse anche in ragione della sottorappresentazione delle donne nella sfera della politica. Si tratta di un deficit democratico che coinvolge i sistemi politici moderni nel loro complesso, ma che interessa l'Italia con una particolare gravità ed evidenza. La questione della sottorappresentazione politica delle donne è stata sinora affrontata prevalentemente in termini tecnico-legali (politiche di pari opportunità ed azione positiva, o di teoria politica (la dicotomia pubblico-maschile e privato-femminile come fondamento del contratto sessuale della politica. Mancano invece contributi che guardino ai partiti come organizzazioni largamente responsabili dei processi di selezione e promozione delle carriere politiche, dunque come luoghi di quotidiana produzione di pratiche e culture di genere, più o meno egualitarie o, viceversa, discriminatorie. Sulla base di tale vuoto di ricerca e riflessione, il presente articolo si propone di mettere in luce le pratiche e le culture di genere che emergono dai racconti di uomini e donne all'interno di due organizzazioni partitiche, una di destra e una di sinistra, situate nel contesto territoriale della provincia di Trento. La ricerca è stata condotta attraverso lo strumento dell'intervista semi-strutturata, coinvolgendo quattro donne e quattro uomini, divisi per coppie di età (un uomo ed una donna giovani ed un uomo ed una donna da lungo presenti nel partito, accostabili per quanto concerne ruolo e posizione nelle organizzazioni partitiche considerate. L'attenzione analitica si è concentrata sulla costruzione del genere di uomini e donne intervistati/e, intesa sia come dimensione ed esperienza individuale (le storie di genere dei/lle singoli/e, sia come dimensione organizzativa più ampia (le storie di genere delle organizzazioni, narrate dalle diverse voci. Un'ulteriore dimensione analitica

  12. What's your story?

    Science.gov (United States)

    Ibarra, Herminia; Lineback, Kent

    2005-01-01

    When you're in the midst of a major career change, telling stories about your professional self can inspire others' belief in your character and in your capacity to take a leap and land on your feet. It also can help you believe in yourself. A narrative thread will give meaning to your career history; it will assure you that, in moving on to something new, you are not discarding everything you've worked so hard to accomplish. Unfortunately, the authors explain in this article, most of us fail to use the power of storytelling in pursuit of our professional goals, or we do it badly. Tales of transition are especially challenging. Not knowing how to reconcile the built-in discontinuities in our work lives, we often relay just the facts. We present ourselves as safe--and dull and unremarkable. That's not a necessary compromise. A transition story has inherent dramatic appeal. The protagonist is you, of course, and what's at stake is your career. Perhaps you've come to an event or insight that represents a point of no return. It's this kind of break with the past that will force you to discover and reveal who you really are. Discontinuity and tension are part of the experience. If these elements are missing from your career story, the tale will fall flat. With all these twists and turns, how do you demonstrate stability and earn listeners' trust? By emphasizing continuity and causality--in other words, by showing that your past is related to the present and, from that trajectory, conveying that a solid future is in sight. If you can make your story of transition cohere, you will have gone far in convincing the listener--and reassuring yourself--that the change makes sense for you and is likely to bring success.

  13. Stories as case knowledge: case knowledge as stories.

    Science.gov (United States)

    Cox, K

    2001-09-01

    Every case contains a human story of illness and a medical story of disease, which together cover person management, case management, health system management and self-management. Much of that management can be learned via a thorough set of stories of typical and atypical core cases compiled by clinical teachers. Stories provide a highly flexible framework for illustrating the lessons of experience, the tips and traps for young players, and the dilemmas requiring careful judgement in the trade-offs between benefits and risks. Listening to real stories unfold is much more fun than being lectured (and better remembered). Stories illustrate 'what can happen' in a case as a guide to 'what to do'. A story begins with a real world situation with some predicament and a (causal) sequence of events or plot in which things are resolved one way or another. Patients tell their illness story; their clinician translates that into a disease story. Stories sort out what is important in such a predicament, consider the strategy and tactics of what to do, and speak about the outcomes. Each local situation provides relevance, context and circumstantial detail. Stories about case management can encapsulate practical knowledge, logical deduction, judgement and decision making, sharing with the student all the ingredients that develop expertise. Sometimes it is the plot that is important, sometimes the detail, sometimes it is the underlying message, the parable that resonates with the listener's experiences and feelings.1 Stories can also accommodate the complexity of multiple variables and the influence of other stakeholders, the uncertainties and dilemmas within the trade-offs, and the niceties of 'informed judgement'. This paper makes four points. First, clinical stories recount pointed examples of 'what happened' that expand our expertise in handling 'a case like that'. Second, cases are the unit of clinical work. Case stories expand the dimensions and details of case knowledge

  14. FLU VACCINATION

    CERN Multimedia

    2007-01-01

    People working on the CERN site who wish to be vaccinated may go to the Infirmary (ground-floor, bldg. 57), with their vaccine, without a prior appointment. The vaccine can be reimbursed directly by Uniqa providing you attach the receipt and the prescription that you will receive from the Medical Service the day of your injection at the infirmary. Ideally, the vaccination should take place between 1st October and 30th November 2007 (preferably between 14:00 and 16:00). CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor. Medical Service

  15. Ghost-Story Telling: Keeping It Appropriate.

    Science.gov (United States)

    Weintraub, Jeff

    1996-01-01

    Guidelines for telling ghost stories at camp involve considering children's fears at different ages, telling age appropriate stories, determining appropriate times for telling ghost stories, and minimizing fear when a child becomes frightened by a ghost story. Includes tips on the selection, preparation, and presentation of ghost stories. (LP)

  16. Hepatitis Vaccines

    Directory of Open Access Journals (Sweden)

    Sina Ogholikhan

    2016-03-01

    Full Text Available Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver.

  17. Hepatitis Vaccines

    Science.gov (United States)

    Ogholikhan, Sina; Schwarz, Kathleen B.

    2016-01-01

    Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver. PMID:26978406

  18. Humidifier disinfectants, unfinished stories

    Directory of Open Access Journals (Sweden)

    Yeyong Choi

    2016-02-01

    Full Text Available Once released into the air, humidifier disinfectants became tiny nano-size particles, and resulted in chemical bronchoalveolitis. Families had lost their most beloved members, and even some of them became broken. Based on an estimate of two million potential victims who had experienced adverse effects from the use of humidifier disinfectants, we can say that what we have observed was only the tip of the iceberg. Problems of entire airways, as well as other systemic effects, should be examined, as we know these nano-size particles can irritate cell membranes and migrate into systemic circulation. The story of humidifier disinfectant is not finished yet.

  19. Stories in the Data.

    Science.gov (United States)

    Singh, Gary

    2017-01-01

    To some degree, comics have always been used to convert data into stories, from ancient Egyptian heiroglyphics to crude biology diagrams in grade-school textbooks. By their very nature, comics communicate through a variety of visualization techniques. Benjamin Bach, who along with his coauthors Nathalie Henry Riche, Sheelagh Carpendale, and Hanspeter Pfister created this issue's Art on Graphics special contribution about the emerging genre of data comics, here talks about their attempts to leverage the massive untapped potential for data-driven comics to explain multiple threads of simultaneous data.

  20. Learning the Patient's Story.

    Science.gov (United States)

    Ragan, Sandra L; Kanter, Elisa

    2017-12-01

    To provide a brief history on narrative medicine and highlight its importance in providing quality patient care. Explains narrative medicine using published, peer-reviewed literature and highlights some of the literary, medical, sociological, and communication perspectives that contributed to the narrative medicine movement. A commitment to the patient-provider relationship and knowing the patient's story is a critical aspect in providing quality cancer care. Teaching oncology nurses skills that are grounded in narrative medicine will improve health care by increasing the nurses' knowledge of their patients and strengthening the nurse-patient relationship. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Telling better stories: strengthening the story in story and simulation

    Science.gov (United States)

    Kemp-Benedict, Eric

    2012-12-01

    information available at that time, based on statements that appear in the SRES itself. The CIB method is a technique for constructing internally consistent qualitative scenarios. Global-scale scenario exercises, in particular climate scenarios, typically include both qualitative (narrative) and quantitative (model) elements. As noted by Schweizer and Kriegler, the dominant method for such studies, which Alcamo (2001, 2008) formalized and named the 'story and simulation' (SAS) approach, relies at least in part on quantitative modeling to ensure consistency. Schweizer and Kriegler rightly criticize the idea that models alone can ensure consistency of a scenario narrative. By itself, this critique is not new. Indeed, if asked, both Alcamo and Raskin et al (Raskin et al 2005), whom Schweizer and Kriegler (2012) cite, would probably agree with them; both sources emphasize the need for qualitative storylines that go beyond what models can provide. However, Schweizer and Kriegler correctly point out that these sources provide little or no guidance to those responsible for the narratives beyond a dialog with the model outputs. The CIB method addresses this problem, and Schweizer and Kriegler's application of the method shows that even the best narrative-writing teams can benefit from this guidance. While the paper of Schweizer and Kriegler makes a compelling argument for using CIB in global scenarios, it should be used in combination with other methods. A scenario exercise has several aims, of which consistency is one. Another important goal is diversity: given a set of internally consistent scenarios, a diverse set covers the space of possibilities, and thereby helps users of the scenarios avoid underestimating or overestimating the potential for change in one or another key factor (e.g., see (Carlsen 2009)). From this point of view, the SRES authors could legitimately respond to Schweizer and Kriegler's finding that the SRES scenarios excluded interesting variants on coal

  2. Mechanism of story elements in the Forud story of Shahname

    Directory of Open Access Journals (Sweden)

    hojjatollah Hemmati

    2016-06-01

    Full Text Available Abstract Which by their nature narrative structure elements , motifs and narrative action takes place . Author In light of these characteristics and structural elements such as plot , point of view , conflict, crisis , climax and relief , follow the narrative structure down. In this study is to investigate the structure of the story landed in Shahnameh . For this purpose, the definition of story and structure delivers And a review of such issues to investigate this story. And to provide this evidence to conclude that the text of traditions and story And a coherent and systematic plan and that it regulates the relations of cause and effect . And shows the text with the help of fictional elements From a stable position starts And stable position and different ends.     Abstract Which by their nature narrative structure elements , motifs and narrative action takes place . Author In light of these characteristics and structural elements such as plot , point of view , conflict, crisis , climax and relief , follow the narrative structure down. In this study is to investigate the structure of the story landed in Shahnameh . For this purpose, the definition of story and structure delivers And a review of such issues to investigate this story. And to provide this evidence to conclude that the text of traditions and story And a coherent and systematic plan and that it regulates the relations of cause and effect . And shows the text with the help of fictional elements From a stable position starts And stable position and different ends.

  3. Artifacts as Stories: Understanding Families, Digital Literacies, and Storied Lives

    Science.gov (United States)

    Lewis Ellison, Tisha

    2016-01-01

    This column focuses on the interactions during family and group conversation circles that not only helped participants talk about personal, emotional, and social issues in their digital stories but also helped them make sense of artifacts and the meanings that stories carry in shared spaces and practices. This work adds to the bourgeoning…

  4. An International Inquiry: Stories of Poverty--Poverty Stories

    Science.gov (United States)

    Ciuffetelli Parker, Darlene; Craig, Cheryl J.

    2017-01-01

    This article features an international inquiry of two high-poverty urban schools, one Canadian and one American. The article examines poverty in terms of "small stories" that educators and students live and tell, often on the edges, unheard and unaccounted for in grand narratives. It also expands the story constellations approach to…

  5. Flu Vaccination

    CERN Multimedia

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  6. Flu vaccination

    CERN Multimedia

    CERN Medical Service

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor.CERN Medical Service

  7. FLU VACCINATION

    CERN Multimedia

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  8. Flu Vaccination

    CERN Multimedia

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical service

  9. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... thanks 3-months free Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe ... This vignette shares the story of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates ...

  10. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... Queue Queue __count__/__total__ Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe ... This vignette shares the story of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates ...

  11. Telling Feminist Stories

    Directory of Open Access Journals (Sweden)

    Clare Hemmings

    2009-01-01

    Full Text Available This article identifies and analyses the dominant stories that academics tell about the development of Western second wave feminist theory. Through an examination of recent production of interdisciplinary feminist and cultural theory journals, I suggest that despite a rhetorical insistence on multiple feminisms, Western feminist trajectories emerge as startlingly singular. In particular, I am critical of an insistent narrative that sees the development of feminist thought as a relentless march of progress or loss. This dominant approach oversimplifies the complex history of Western feminisms, fixes writers and perspectives within a particular decade, and repeatedly (and erroneously positions poststructuralist feminists as ‘the first’ to challenge the category ‘woman’ as the subject and object of feminist knowledge. Rather than provide a corrective history of Western feminist theory, the article interrogates the techniques through which this dominant story is secured, despite the fact that we (feminist theorists know better. My focus, therefore, is on citation patterns, discursive framings and some of their textual, theoretical and political effects. As an alternative, I suggest a realignment of key theorists purported to provide a critical break in feminist theory with their feminist citational traces, to force a concomitant re-imagining of our historical legacy and our place within it.

  12. The StorySpinner Sculptural Reader

    OpenAIRE

    Hooper, Clare; Weal, Mark

    2005-01-01

    This demo is of a hypertext reading system called StorySpinner. It follows the sculptural hypertext methodology and has been used as a test bed for experimenting with the authoring of narrative flow in automatically generated stories. Readers are able to select and read one of two available stories. Reading a story involves selecting tarot cards which are mapped to chunks of story text based on possible interpretations of the cards and information concerning current story state.

  13. The Sam and Nora Stories.

    Science.gov (United States)

    Nijim, Basheer; Nijim, Germana

    1992-01-01

    Presents a series of five short stories for children that incorporate geographic concepts. Includes the concepts of region, boundaries, and grids. Suggests that the stories will help children master challenging concepts and vocabulary that in turn will increase their knowledge and self-esteem. (DK)

  14. Readiness for Solving Story Problems.

    Science.gov (United States)

    Dunlap, William F.

    1982-01-01

    Readiness activities are described which are designed to help learning disabled (LD) students learn to perform computations in story problems. Activities proceed from concrete objects to numbers and involve the students in devising story problems. The language experience approach is incorporated with the enactive, iconic, and symbolic levels of…

  15. Everybody Has a Story III

    DEFF Research Database (Denmark)

    . The teacher, Erin Gruwell, found herself more or less forced to base her teachings on the stories of the living conditions of her students. When she became aware of these stories and managed to relate the content of the curriculum to them, her students started to find interest in the subjects of the school...

  16. Sweet Secrets: Stories of Menstruation.

    Science.gov (United States)

    O'Grady, Kathleen; Wansbrough, Paula

    This book combines short stories with clear, factual health information for adolescent females about menstruation and their bodily changes they are experiencing. It focuses on young girls' concerns and questions about menstruation and educates through a combination of the front matter and the stories themselves. Coming from different generations…

  17. story from the joseph narrative

    African Journals Online (AJOL)

    The story of Judah within the longer Joseph story (Genesis 37-50) provides an apt place for .... from the center, to honor all humans with absolute justice, equity, respect; to refrain ..... they were simply general behavior types with no relation to me (too abstract) ... the Bible and extract theology and then replicate it into theory.

  18. Digital Media Stories for Persuasion

    Science.gov (United States)

    Leopold, Lisa

    2010-01-01

    Digital media story-telling (which enhances traditional oral story-telling with images, music, and text) has been a focus of recent scholarship for its potential to produce numerous educational benefits. Through digital media storytelling, students' imagination, creativity, critical thinking, writing, public speaking, and organizational or…

  19. DNA Vaccines

    Indian Academy of Sciences (India)

    diseases. Keywords. DNA vaccine, immune response, antibodies, infectious diseases. GENERAL .... tein vaccines require expensive virus/protein purification tech- niques as ... sphere continue to remain major health hazards in developing nations. ... significance since it can be produced at a very low cost and can be stored ...

  20. Vaccination Policies

    NARCIS (Netherlands)

    Verweij, M.F.

    2013-01-01

    Vaccination involves priming the immune system with an antigenic agent that mimics a virus or bacterium, which results in immunity against the “real” microorganism. Collective vaccination policies have played an important role in the control of infectious disease worldwide. They can serve the

  1. TUMOUR VACCINE

    NARCIS (Netherlands)

    Wagner, Ernst; Kircheis, Ralf; Crommelin, D.; Van Slooten, Maaike; Storm, Gert

    1999-01-01

    The invention relates to a tumour vaccine with a tumour antigen base. In addition to a source of tumour antigens, the vaccine contains a release system for the delayed release of the active agent IFN- gamma , the active dose of IFN- gamma being 50 ng to 5 mu g. The IFN- gamma is released over a

  2. Rotavirus Vaccine

    Science.gov (United States)

    Why get vaccinated?Rotavirus is a virus that causes diarrhea, mostly in babies and young children. The diarrhea can be severe, and lead ... and fever are also common in babies with rotavirus.Before rotavirus vaccine, rotavirus disease was a common ...

  3. StoryTrek: Experiencing Stories in the Real World

    DEFF Research Database (Denmark)

    Khaled, Rilla; Barr, Pippin James; Greenspan, Brian

    2011-01-01

    world experience. In early tests we observed the emergence of a number of recurrent themes in participants’ experiences which are characteristic of the StoryTrek system, but which also help us to understand locative media storytelling affordances more generally. In this paper we present the system......In this paper we introduce StoryTrek, a locative hypernarrative system developed to generate stories based on a reader’s location and specific movements in the real world. This creates, for readers, an interplay between navigation, narrative, and agency, as well as between the fictional and real...

  4. StoryTrek: Experiencing Stories in the Real World

    DEFF Research Database (Denmark)

    Khaled, Rilla; Barr, Pippin James; Greenspan, Brian

    2011-01-01

    In this paper we introduce StoryTrek, a locative hypernarrative system developed to generate stories based on a reader’s location and specific movements in the real world. This creates, for readers, an interplay between navigation, narrative, and agency, as well as between the fictional and real...... world experience. In early tests we observed the emergence of a number of recurrent themes in participants’ experiences which are characteristic of the StoryTrek system, but which also help us to understand locative media storytelling affordances more generally. In this paper we present the system...

  5. The Singapore research story

    CERN Document Server

    Teck Seng, Low; Thampuran, Raj

    2016-01-01

    Ever since Singapore became independent in 1965, its leaders have invested tremendous efforts and resources to develop its economy in order to create jobs for its people and to support national development. This book describes the challenging journey of Singapore in developing a knowledge-based economy driven by research and innovation and the roles played by research institutes, universities, research manpower and appropriate collaboration between research institutes and industry. The book traces the foundations of Singapore's research story from the time of its independence in 1965 to the present day. Through interviews with the key players and research into the records, the establishment of the key institutes and the roles of a global cast of researchers, scientists and engineers in setting up the R&D infrastructure are outlined. The impact that the concerted efforts of the last 25 years to build up a credible and world-class research capability in Singapore is discussed, as are the tremendous challeng...

  6. A Little Solar Story

    DEFF Research Database (Denmark)

    Ahmad, Bashir

    1997-01-01

    Experiences from use of solar cookers in India and many other places are different. But the story which is based on a field study in Gujarat state of India shows that during last twenty years there has been a tendency that many families do not continue to use their solar cookers. The study shows...... that the tendency is related with the lack of compatibility of this new technology (solar cooker) with the everyday real-life conditions of the families. In principle the findings are supported by an evaluation report on a solar cooker project in Burkina Faso. The conclusion is that the user should be involved...... in the solar cooker technological development process....

  7. Story and Real Life

    Directory of Open Access Journals (Sweden)

    Robert P. Waxler

    2013-06-01

    Full Text Available Why should we be concerned about the fate of literature as we move from a book culture to a screen culture in the digital age? Not primarily because we are losing our sense of story, but because we are losing our sense of the central importance of linguistic narrative. There is a difference. The technologies creating the digital revolution seem to devalue language and increasingly to do away with boundaries, celebrating instead speed and boundless exhilaration. The visual trumps the linguistic, the image and the screen trump the word and the book. As a result, we no longer seem to engage deeply with others or ourselves. We are beginning to move, in other words, from “a reading brain” to “a digital brain,” from a brain capable of deep reading and deep thinking to a brain increasingly addled by spectacle and surface sensation. We are losing our standing as “linguistic beings.”

  8. The Yellow Fever Vaccine: A History

    OpenAIRE

    Frierson, J. Gordon

    2010-01-01

    After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ability to produce the vaccine on a large scale in eggs; and the removal of dangerous contaminants. An important person in the story is Max Theiler, who was Prof...

  9. Constructing leadership identities through stories

    DEFF Research Database (Denmark)

    Frimann, Søren; Hersted, Lone

    2016-01-01

    This article analyzes the construction of leadership identities through stories found in four narrative interviews from a qualitative study and leadership development project based on social constructionism and action learning. We argue that leadership development and the construction of leadership...... that the concept of coauthoring is useful in developing leadership and leadership identities through reflexive dialogs and emerging stories....... identities in a postmodern paradigm are based on the negotiation and co-construction of meanings, relationships, and stories. The following questions are investigated: What happens when a group of leaders from different organizations construct, deconstruct, and reconstruct their identity as leaders through...

  10. Introducing Interactive Technology--"Toy Story 3"

    Science.gov (United States)

    Nikirk, Martin

    2011-01-01

    "To infinity and beyond!" is the catchphrase of Buzz Lightyear, Universe Protection Unit space ranger, a character in the Disney/Pixar "Toy Story" franchise. The three films in the franchise--"Toy Story," 1993; "Toy Story 2," 1999; and "Toy Story 3," 2010--incorporate an innovative blend of many different genres, having spun off video games and…

  11. Co-Story-ing: Collaborative Story Writing with Children Who Fear

    Science.gov (United States)

    Pehrsson, Dale-Elizabeth

    2007-01-01

    This article offers a guide for using collaborative story writing (co-story-ing), an assessment technique as well as a therapeutic intervention for children who demonstrate fears, extreme shyness and difficulty in establishing relationships. Co-story-ing draws from Gardner's Mutual Story Telling Technique. Co-story-ing guides clients as they…

  12. Whither vaccines?

    Science.gov (United States)

    Rodrigues, Charlene M C; Pinto, Marta V; Sadarangani, Manish; Plotkin, Stanley A

    2017-06-01

    Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas. © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  13. NIB Commentary on Oncofertility Stories.

    Science.gov (United States)

    Gremmels, Becket

    2017-01-01

    The authors of these stories describe tales of struggle with cancer and secondary infertility. Yet, they each have a different response to similar circumstances. Their stories touch on a lack of informed consent regarding infertility, spiritual discussions of the problem of evil, the need for improved collaboration among physicians to further care of the whole person, societal norms regarding reproduction and gender roles, the injustice of cancer in young people, and other topics. Of note, no stories mention prominent ethical concerns of in-vitro fertilization like how couples should deal with "extra" frozen embryos or concerns about the potential for commodification of children. This shows a disconnect between the concerns of bioethicists and the concerns of real patients facing actual problems. Both cancer patients and providers can learn something from these stories that directly apply to their lives.

  14. Transmedia storytelling on travel stories

    Directory of Open Access Journals (Sweden)

    Adolfo Baltar Moreno

    2016-01-01

    Full Text Available Travel stories form part of a great tradition inside Western Culture which has served historically to describe, to understand and to imagine other cul - tures and communities, far or near, being constituted into a real narra - tive genre. This type of story has been and is a reflection of the perception of the world based on the imaginary worlds created by the travelling narrators. How do modern authors of travel stories take advantage of the opportunities offered by transmedia storytelling? The present article explores the potential of these types of stories as a privileged object of study for transmedia storytelling studies, from the analysis of a sample of 80 narrative productions based on experiences of travel and presented in diverse editions of the Festival Le Grand Bivouac (France. It also shows the existence of a new contemporary trend inside this narrative form that transcends its literary nature.

  15. The story of mathematics

    CERN Document Server

    Mankiewicz, Richard

    2000-01-01

    Questioning how mathematics has evolved over the centuries and for what reasons; how human endeavour and changes in the way we live have been dependent on mathematics, this book tells the story of the impact this intellectual activity has had across cultures and civilizations. It shows how, far from being just the obsession of an elite group of philosophers, priests and scientists, mathematics has in some shape or other entered every area of human activity. The mysterious tally sticks of prehistoric peoples and the terrestial maps used for trade, exploration and warfare; the perennial fascination with the motions of heavenly bodies and changing perspectives on the art and science of vision; all are testament to a mathematics at the heart of history. The path of this changing discipline is marked by a wealth of images, from medieval manuscripts to the unsettling art of Dali or Duchamp, from the austere beauty of Babylonian clay tablets to the delicate complexity of computer-generated images. The text encompass...

  16. Influenza vaccination

    DEFF Research Database (Denmark)

    Østerhus, Sven Frederick

    2015-01-01

    The Cochrane Library was systematically searched for meta-analyses regarding influenza vaccination of various populations, both healthy and sick. An effect in reducing the number of cases of influenza, influenza-like illness or complications to influenza was found in some studies, but, generally......, the quality of the studies was low, and several studies lacked hard clinical endpoints. Data on adverse effects were scarce. More randomised controlled trials investigating the effects of influenza vaccination are warranted....

  17. Flu Vaccine Safety Information

    Science.gov (United States)

    ... Influenza Types Seasonal Avian Swine Variant Pandemic Other Flu Vaccine Safety Information Questions & Answers Language: English (US) ... safety of flu vaccines monitored? Egg Allergy Are flu vaccines safe? Flu vaccines have good safety record. ...

  18. Thimerosal in Flu Vaccine

    Science.gov (United States)

    ... Seasonal Avian Swine Variant Pandemic Other Thimerosal in Flu Vaccine Questions & Answers Language: English (US) Español Recommend ... and/or fungi from contaminating the vaccine. Do flu vaccines contain thimerosal? Flu vaccines in multi-dose ...

  19. Ear Infection and Vaccines

    Science.gov (United States)

    ... an ENT Doctor Near You Ear Infection and Vaccines Ear Infection and Vaccines Patient Health Information News ... or may need reinsertion over time. What about vaccines? A vaccine is a preparation administered to stimulate ...

  20. Antipneumococcal vaccination

    Directory of Open Access Journals (Sweden)

    Gian Vincenzo Zuccotti

    2013-06-01

    Full Text Available Streptococcus pneumoniae (SP is a gram-positive bacterium with more than 90 known serotypes causing around 11% of all deaths worldwide in children aged 1-59 months. A new era in prevention of SP-related diseases started in at the beginning of 2000s when a 7-valent pneumococcal conjugate vaccine (PCV7 was recommended as the vaccine of choice in pediatric age. PCV7 dramatically reduced invasive pneumococcal diseases (IPD among children with indirect effects noted among other age groups as well. However, thanks to a strict surveillance network, an increase in non-vaccine serotypes (NVTs causing IPD was noted worldwide and in late 2000s a new second generation vaccine (13-valent pneumococcal conjugate vaccine-PCV13 with an expanded serotype coverage was licensed. Due to the lack of solid effectiveness data, up to know it is difficult to predict how the composition of NVTs will change after the large-scale introduction of PCV13 or whether the characteristics of the serotypes will change. Long-term surveillance of both IPD, pneumonia, acute otitis media and carriage will be crucial to ascertain whether these second generation vaccines are having the desired effect of reducing the incidence of diseases in the long term. Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge research

  1. Vaccine Hesitancy and Online Information: The Influence of Digital Networks.

    Science.gov (United States)

    Getman, Rebekah; Helmi, Mohammad; Roberts, Hal; Yansane, Alfa; Cutler, David; Seymour, Brittany

    2017-12-01

    This article analyzes the digital childhood vaccination information network for vaccine-hesitant parents. The goal of this study was to explore the structure and influence of vaccine-hesitant content online by generating a database and network analysis of vaccine-relevant content. We used Media Cloud, a searchable big-data platform of over 550 million stories from 50,000 media sources, for quantitative and qualitative study of an online media sample based on keyword selection. We generated a hyperlink network map and measured indegree centrality of the sources and vaccine sentiment for a random sample of 450 stories. 28,122 publications from 4,817 sources met inclusion criteria. Clustered communities formed based on shared hyperlinks; communities tended to link within, not among, each other. The plurality of information was provaccine (46.44%, 95% confidence interval [39.86%, 53.20%]). The most influential sources were in the health community (National Institutes of Health, Centers for Disease Control and Prevention) or mainstream media ( New York Times); some user-generated sources also had strong influence and were provaccine (Wikipedia). The vaccine-hesitant community rarely interacted with provaccine content and simultaneously used primary provaccine content within vaccine-hesitant narratives. The sentiment of the overall conversation was consistent with scientific evidence. These findings demonstrate an online environment where scientific evidence online drives vaccine information outside of the vaccine-hesitant community but is also prominently used and misused within the robust vaccine-hesitant community. Future communication efforts should take current context into account; more information may not prevent vaccine hesitancy.

  2. Radiation and Anti-Cancer Vaccines: A Winning Combination.

    Science.gov (United States)

    Cadena, Alexandra; Cushman, Taylor R; Anderson, Clark; Barsoumian, Hampartsoum B; Welsh, James W; Cortez, Maria Angelica

    2018-01-30

    The emerging combination of radiation therapy with vaccines is a promising new treatment plan in the fight against cancer. While many cancer vaccines such as MUC1, p53 CpG oligodeoxynucleotide, and SOX2 may be great candidates for antitumor vaccination, there still remain many investigations to be done into possible vaccine combinations. One fruitful partnership that has emerged are anti-tumor vaccines in combination with radiation. Radiation therapy was previously thought to be only a tool for directly or indirectly damaging DNA and therefore causing cancer cell death. Now, with much preclinical and clinical data, radiation has taken on the role of an in situ vaccine. With both cancer vaccines and radiation at our disposal, more and more studies are looking to combining vaccine types such as toll-like receptors, viral components, dendritic-cell-based, and subunit vaccines with radiation. While the outcomes of these combinatory efforts are promising, there is still much work to be covered. This review sheds light on the current state of affairs in cancer vaccines and how radiation will bring its story into the future.

  3. The Story of Azithromycin

    Directory of Open Access Journals (Sweden)

    Banić Tomišić, Z.

    2011-12-01

    the negotiations and signing of a contract between PLIVA, Croatian pharmaceutical company, the patent holder, and Pfizer, one of the world largest pharmaceutical companies in the field of proprietary research. The dihydrate form of azithromycin is also discussed. The azithromycin (i.e. Sumamed and Zithromax story, which dates from the second half of the last century, can be considered as the first and foremost example of successful knowledge and technology transfer in Croatia ever. On their web pages, the World Intellectual Property Organization (WIPO reports the PLIVA azithromycin story as a case study and excellent example of proactive licensing strategy. For the discovery of azithromycin, in addition to receiving numerous awards, in the year 2000, PLIVA's scientists D. Sc. S. Đokić and M. Sc. G. Kobrehel, together with the representatives from the US-based Pfizer, were granted the honorable titles of "Heroes of Chemistry 2000" by the American Chemical Society (ACS, a non-profit association of American chemists and chemical engineers, and the largest association of scientists in the world. This high award is rightly taken to be also recognition of the achievement of PLIVA's entire team working on azithromycin. The success of azithromycin has placed PLIVA among the few pharmaceutical companies in the world that have developed their own blockbuster drug, and has entitled Croatia to join a small group of nations that have developed a new antibiotic.

  4. The Wellenberg story

    International Nuclear Information System (INIS)

    Untensperger, Marcel A.

    1995-01-01

    In June 1994 two-thirds of the voters present at a community meeting in Wolfenschiessen agreed to host a repository for short-lived low- and intermediate-level (LLW/ILW) waste in the nearby Wellenberg mountain. Wolfenschiessen, located in a farming region in central Switzerland, is a village of 1900 residents. Nagra, the Swiss National Cooperative for the Disposal of Radioactive Waste, was able to celebrate a breakthrough at last. Nuclear opponents criticised that the community had, essentially, been bought by Nagra. But agreements for free electricity, grants and annual payments only represented the culmination of a decade of intense effort by Nagra towards winning local public acceptance for its repository. The host community came to trust Nagra for what we are - a technical service organisation with a federal mandate but with no political power. As a matter of fact, Nagra has encountered much more opposition than acceptance over the years. Our scientists were greeted by residents carrying pitchforks and sticks when attempting to begin experimental field work at one site; due to exhaustive use of Swiss democratic rights, permission to drill at another site was delayed by opponents for eight years. What did Nagra learn from all these obstacles? On its way towards gaining public acceptance, Nagra was confronted with problems in three areas: Fear and safety, NIMBY-syndrome (not in my backyard); Manipulation of public anxiety for individual political gain and as a substratum for arguments against nuclear power. While we at Nagra concede that Wellenberg represents a 'green light', we also know that not all lights ahead will be green. Some will be amber. Is the Wellenberg story one of success? The future will tell us, but a few doors have been opened along the way towards realising a repository for short-lived LLW/ILW in Switzerland

  5. Effective vaccine communication during the disneyland measles outbreak.

    Science.gov (United States)

    Broniatowski, David A; Hilyard, Karen M; Dredze, Mark

    2016-06-14

    Vaccine refusal rates have increased in recent years, highlighting the need for effective risk communication, especially over social media. Fuzzy-trace theory predicts that individuals encode bottom-line meaning ("gist") and statistical information ("verbatim") in parallel and those articles expressing a clear gist will be most compelling. We coded news articles (n=4581) collected during the 2014-2015 Disneyland measles for content including statistics, stories, or bottom-line gists regarding vaccines and vaccine-preventable illnesses. We measured the extent to which articles were compelling by how frequently they were shared on Facebook. The most widely shared articles expressed bottom-line gists, although articles containing statistics were also more likely to be shared than articles lacking statistics. Stories had limited impact on Facebook shares. Results support Fuzzy Trace Theory's predictions regarding the distinct yet parallel impact of categorical gist and statistical verbatim information on public health communication. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. My partner's stories: relationships between personal and vicarious life stories within romantic couples.

    Science.gov (United States)

    Panattoni, Katherine; Thomsen, Dorthe Kirkegaard

    2018-06-12

    In this paper, we examined relationships and differences between personal and vicarious life stories, i.e., the life stories one knows of others. Personal and vicarious life stories of both members of 51 young couples (102 participants), based on McAdams' Life Story Interview (2008), were collected. We found significant positive relationships between participants' personal and vicarious life stories on agency and communion themes and redemption sequences. We also found significant positive relationships between participants' vicarious life stories about their partners and those partners' personal life stories on agency and communion, but not redemption. Furthermore, these relationships were not explained by similarity between couples' two personal life stories, as no associations were found between couples' personal stories on agency, communion and redemption. These results suggest that the way we construct the vicarious life stories of close others may reflect how we construct our personal life stories.

  7. The Path Tells a Story

    Science.gov (United States)

    Nack, Frank

    Stories have been shared in every culture because they are a powerful means to entertain, educate, and preserve traditions or instill values. In the history of storytelling technological evolution has changed the tools available to storytellers, from primarily oral representations that have been enriched with gestures and expressions to the sophisticated forms we enjoy today, such as film or complex layered hypermedia environments. Despite these developments the traditional linear presentation of a story is still the most dominant. Yet, the first decade of the twenty-first century established a technology that finally, after many attempts, can challenge the dogma of passive linearity. It is mobile technology that makes people aware that a digital environment opens opportunities to everybody to freely socialize through and with stories relevant for the current spatial, temporal, and social context.

  8. The novel as short story

    Directory of Open Access Journals (Sweden)

    Kirk Schlueter

    2013-06-01

    Full Text Available In recent history, the novel has been thought of and defined primarily as a long prose narrative. However, this has not been the case historically, as the original meaning of "novel" was for "a piece of news" or "a short story or novella." Returning to this original definition, I propose a new way of viewing the work known contemporarily as the novel as a collection, or sequence, of united short stories rather than a single indivisible work, with the component short stories or novellas comprising the sequence renamed as "novels." A brief examination of several classic works traditionally considered novels serves to illustrate how this change in definition will affect reading.

  9. Physiotherapists' stories about professional development.

    Science.gov (United States)

    Pettersson, Anna F; Bolander Laksov, Klara; Fjellström, Mona

    2015-01-01

    A professional career may extend over a period of 40 years. Although learning is a feature of professional competence, little is known about learning and development after professional entry education. Narrative inquiry was used to understand how physiotherapists learned and developed over time, and stories from a purposeful sample of 12 physiotherapists were collected. Stories were thematically analyzed with regard to key elements related to learning and development, and common themes were identified across stories. Four themes emerged from the analysis where physiotherapists learned and developed in working life: (1) facing challenges; (2) contrasting perspectives; (3) drawing on hundreds of educators; and (4) building on personal experience. Non-formal ways of learning in working life may help physiotherapists learn and develop confidence, communication strategies and different approaches to treatment. Besides reflection on personal experience and patient encounters, learning and development may be promoted and supported by taking on challenges and changing settings.

  10. Exaggerated Claims for Interactive Stories

    Science.gov (United States)

    Thue, David; Bulitko, Vadim; Spetch, Marcia; Webb, Michael

    As advertising becomes more crucial to video games' success, developers risk promoting their products beyond the features that they can actually include. For features of interactive storytelling, the effects of making such exaggerations are not well known, as reports from industry have been anecdotal at best. In this paper, we explore the effects of making exaggerated claims for interactive stories, in the context of the theory of advertising. Results from a human user study show that female players find linear and branching stories to be significantly less enjoyable when they are advertised with exaggerated claims.

  11. Story Bound, Map Around: Stories, Life, and Learning

    Science.gov (United States)

    Martinez, Ulyssa; Nolte-Yupari, Samantha

    2015-01-01

    In this article, the authors discuss mixed-media projects done with elementary students in a summer art camp and preservice elementary teachers taking Visual Arts in the Elementary Classroom, illustrating their consideration of how stories carry the curricular potential to bring students' out-of-school experiences into the classroom. In order…

  12. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... University (NEOMED) 26,193 views 5:39 Little Stars – Paediatric Palliative Care – Charlie's Story - Duration: 10:35. Little Stars 12,759 views 10:35 Teen Cancer Stories | ...

  13. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... it free Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe from NINRnews? ... and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience ...

  14. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... shares the story of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology ...

  15. Green revolution vaccines, edible vaccines | Tripurani | African ...

    African Journals Online (AJOL)

    Edible vaccines are sub-unit vaccines where the selected genes are introduced into the plants and the transgenic plant is then induced to manufacture the encoded protein. Edible vaccines are mucosal-targeted vaccines where stimulation of both systematic and mucosal immune network takes place. Foods under study ...

  16. Stories: A List of Stories to Tell and to Read Aloud.

    Science.gov (United States)

    Greene, Ellin, Comp.

    This booklet contains lists of folk and fairy tales, stories to be read aloud, and books of poetry for young children. It includes references to children's stories from many countries, stories of heroes and saints, and stories for special occasions. A section of source materials for the storyteller is also included along with subject and…

  17. Story-dialogue: creating community through storytelling

    OpenAIRE

    Doyle-Jones, Carol Sarah

    2006-01-01

    This narrative case study examines the role of storytelling in creating community with a grade 7 class. Twelve girls and eleven boys, ages 12 to 13, participated in this classroom-based study. Students engaged in three structured storytelling activities incorporating home-to-school stories, story responses, and classroom presentations. First, students’ parents/guardians told a coming-of-age or Confirmation story to their child. Second, at school, students shared their family story with a part...

  18. Archrtypal Analysis of Bijan and Manije Story

    Directory of Open Access Journals (Sweden)

    Tayebeh Jafari

    2013-04-01

    Full Text Available  Abstract Manije and Bijan story, a poem by a great poet, Firdausi Tousi, like his other stories in Shahname is a story which can be analyzed by archetyoal approach. According to this approach, this story can be considered as the individuation of here of this story, Bijan, who voluntarily enters into the individuation and psychological growth by being called. In his perfection cycle which is started and in Iran, by the trickery of evil wise old (gorgin, Bijan meets his Anima of unconscious. Bijan, who lived in Ashkanian era as some researchers believe, is one of the prime characters in Shahnameh. From mythical point of view, Bijan story, which is known as one of ancient myths, is the indicator of feminine society in Iran. Bijan story, like Bahram Chobin, Rustam and Sohrab, Ardeshir Babakan, and Rustam and Esfandiar, is an independent story added to Shahnameh. The comparison of Bijan story with other stories of Shahnameh represents this issue that Ferdowsi composed Bijan story in his youth and just after Daghighi’s death. Because Bijan story, like most other stories of Shahnameh and other myths, has a quite symbolic structure and motifs, Jung archetypal point of view is helpful to discover a lot of mysteries. In the present article, Bijan story is analyzed from Jung’s archetypal point of view. According to this theory, there are a lot of symbols, motifs and archetypes in this story. There is a united structure in every story formed base on its plot thus, to discover the structure of a symbolic story is an important act.   The symbolic motif of Bijan story is reaching the perfection and the story structure is completely commensurate with this motif the move is started from Iran, which is the indicator of Bijan story’s consciousness, then the hero after getting individual experience in land of unconscious, Turan, comes back to Iran. Bijan voluntary goes on a dangerous and symbolic way as the hero. Actually he is the portrayal

  19. Valuing vaccination.

    Science.gov (United States)

    Bärnighausen, Till; Bloom, David E; Cafiero-Fonseca, Elizabeth T; O'Brien, Jennifer Carroll

    2014-08-26

    Vaccination has led to remarkable health gains over the last century. However, large coverage gaps remain, which will require significant financial resources and political will to address. In recent years, a compelling line of inquiry has established the economic benefits of health, at both the individual and aggregate levels. Most existing economic evaluations of particular health interventions fail to account for this new research, leading to potentially sizable undervaluation of those interventions. In line with this new research, we set forth a framework for conceptualizing the full benefits of vaccination, including avoided medical care costs, outcome-related productivity gains, behavior-related productivity gains, community health externalities, community economic externalities, and the value of risk reduction and pure health gains. We also review literature highlighting the magnitude of these sources of benefit for different vaccinations. Finally, we outline the steps that need to be taken to implement a broad-approach economic evaluation and discuss the implications of this work for research, policy, and resource allocation for vaccine development and delivery.

  20. Story Presentation Effects on Children's Retell Content

    Science.gov (United States)

    Schneider, Phyllis; Dube, Rita Vis

    2005-01-01

    This study investigated the possibility that the amount of content children include in their stories is affected by how stories are presented. Simple stories were presented to kindergarten and Grade 2 children in 3 conditions: orally (oral only), pictorially (pictures only), and combined oral and pictures. The kindergarteners recalled more content…

  1. Every Picture Tells a Story

    NARCIS (Netherlands)

    Dr. Piet Bakker

    2011-01-01

    Het doel van het project Every Picture Tells a Story is om samen met het werkveld methoden, technieken en kennis te ontwikkelen voor het produceren van effectieve infographics. Dit is nodig omdat de vraag naar infographics in de markt snel toeneemt. Bedrijfsleven en overheden kiezen er steeds vaker

  2. Turning Scientific Presentations into Stories

    Science.gov (United States)

    Aruffo, Christopher

    2015-01-01

    To increase students' confidence in giving scientific presentations, students were shown how to present scientific findings as a narrative story. Students who were preparing to give a scientific talk attended a workshop in which they were encouraged to experience the similarities between telling a personal anecdote and presenting scientific data.…

  3. Learning through Dramatic Story Presentation

    Science.gov (United States)

    Tindall, Evie

    2012-01-01

    The use of story with dramatic presentation approaches produces an engaging and powerful instructional choice for today's adult ESL educators. Two engaging and timed-tested approaches are Reader's Theater and Tableau Vivant. Both provide English language learners with content tailored to their abilities in addition to numerable opportunities to…

  4. Teaching about Consumerism through Stories

    Science.gov (United States)

    Haas, Kay Parks

    2010-01-01

    One of the best methods in the English language arts classroom is to educate students through the world of stories. The beauty of storytelling is that it often has a more powerful impact on young adults than a didactic lecture or a textbook chapter. Many times students would say that they internalize a message much more willingly through reading a…

  5. Sound Stories for General Music

    Science.gov (United States)

    Cardany, Audrey Berger

    2013-01-01

    Language and music literacy share a similar process of understanding that progresses from sensory experience to symbolic representation. The author identifies Bruner’s modes of understanding as they relate to using narrative in the music classroom to enhance music reading at iconic and symbolic levels. Two sound stories are included for…

  6. Story Lab: Student Data Privacy

    Science.gov (United States)

    Herold, Benjamin

    2015-01-01

    Student data privacy is an increasingly high-profile--and controversial--issue that touches schools and families across the country. There are stories to tell in virtually every community. About three dozen states have passed legislation addressing student data privacy in the past two years, and eight different proposals were floating around…

  7. Melting Pots: Family Stories & Recipes.

    Science.gov (United States)

    Weber, Judith Eichler

    Discussing the different ways people (including Chinese, Greek, African-American, English, and Cuban) celebrate with food, this book presents a brief account of various celebrations followed by a short story involving each celebration. Celebrations discussed in the book are family parties, birthday parties, school parties, surprise parties, and…

  8. Exploring Vaccine Hesitancy Through an Artist-Scientist Collaboration : Visualizing Vaccine-Critical Parents' Health Beliefs.

    Science.gov (United States)

    Koski, Kaisu; Holst, Johan

    2017-09-01

    This project explores vaccine hesitancy through an artist-scientist collaboration. It aims to create better understanding of vaccine hesitant parents' health beliefs and how these influence their vaccine-critical decisions. The project interviews vaccine-hesitant parents in the Netherlands and Finland and develops experimental visual-narrative means to analyse the interview data. Vaccine-hesitant parents' health beliefs are, in this study, expressed through stories, and they are paralleled with so-called illness narratives. The study explores the following four main health beliefs originating from the parents' interviews: (1) perceived benefits of illness, (2) belief in the body's intelligence and self-healing capacity, (3) beliefs about the "inside-outside" flow of substances in the body, and (4) view of death as a natural part of life. These beliefs are interpreted through arts-based diagrammatic representations. These diagrams, merging multiple aspects of the parents' narratives, are subsequently used in a collaborative meaning-making dialogue between the artist and the scientist. The resulting dialogue contrasts the health beliefs behind vaccine hesitancy with scientific knowledge, as well as the authors' personal, and differing, attitudes toward these.

  9. Vaccines and Thimerosal

    Science.gov (United States)

    ... During Pregnancy Frequently Asked Questions about Vaccine Recalls Historical Vaccine Safety Concerns FAQs about GBS and Menactra ... CISA Resources for Healthcare Professionals Evaluation Current Studies Historical Background 2001-12 Publications Technical Reports Vaccine Safety ...

  10. Vaccine Adverse Events

    Science.gov (United States)

    ... for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More sharing ... in the primary immunization series in infants Report Adverse Event Report a Vaccine Adverse Event Contact FDA ( ...

  11. Vaccination in Fish

    DEFF Research Database (Denmark)

    Chettri, Jiwan Kumar

    vaccines have reduced the need for usage of antibiotics with more than 99 % since the 1980s. Fish can be vaccinated by three different administration routes: injection, immersion and oral vaccination. Injection vaccination (intraperitoneal injection of vaccine) is the most time consuming and labor...... intensive method, which however, provides the best protection of the fish. Immersion vaccination is used for immunization of a high number of small fish is cost-efficient and fast (30 sec immersion into vaccine). Oral vaccination (vaccine in feed) is the least efficient. As in higher vertebrates fish...... respond to vaccination by increasing the specific antibody titer and by activating the cellular responses. My talk will cover vaccination methods in fish, immune responses and some adverse effect of oil-adjuvanted vaccines in fish with reference to our work in rainbow trout, Oncorhynchus mykiss....

  12. Human Papillomavirus (HPV) Vaccine

    Science.gov (United States)

    Why get vaccinated?HPV vaccine prevents infection with human papillomavirus (HPV) types that are associated with cause ... at http://www.cdc.gov/hpv. HPV Vaccine (Human Papillomavirus) Information Statement. U.S. Department of Health and ...

  13. [Poliovirus vaccine].

    Science.gov (United States)

    Shimizu, Hiroyuki

    2012-06-01

    To avoid the risk of vaccine-associated paralytic poliomyelitis (VAPP) and polio outbreaks due to circulating vaccine-derived polioviruses, an inactivated poliovirus vaccine (IPV) was introduced for routine immunization in a number of countries with a low risk of polio outbreaks. Currently, production and marketing of a standalone conventional IPV and two diphtheria-pertussis-tetanus-IPV (Sabin-derived IPV; sIPV) products have been submitted, and it is expected that the IPV products will be introduced in Japan in the autumn of 2012. At the same time, a decline in the OPV immunization rate became apparent in Japan due to serious public concerns about a remaining risk of VAPP and introduction of IPV in the near future. Therefore, the recent development of polio immunity gaps should be carefully monitored, and surveillance of suspected polio cases and laboratory diagnosis of polioviruses have to be intensified for the transition period from OPV to IPV in Japan. The development of sIPV is one of the most realistic options to introduce affordable IPV to developing countries. In this regard, further clinical studies on its efficacy, safety, and interchangeability of sIPV will be needed after the introduction of the sIPV products, which will be licensed in Japan for the first time in the world.

  14. Hepatitis B Vaccine

    Science.gov (United States)

    ... a combination product containing Haemophilus influenzae type b, Hepatitis B Vaccine) ... combination product containing Diphtheria, Tetanus Toxoids, Acellular Pertussis, Hepatitis B, Polio Vaccine)

  15. Clarification on RIA Novosti Story

    International Nuclear Information System (INIS)

    2014-01-01

    Full text: ''On 21 May, RIA Novosti news agency published a story headlined IAEA Says Impossible for Ukraine to Switch to US Nuclear Fuel, based on apparent remarks by an Agency official during a News Conference in Moscow. There was some confusion about the official's remarks, which were made in Russian. The resulting RIA Novosti story does not accurately reflect his words, nor the position of the IAEA, which is as follows: The choice of supplier for nuclear fuel is the prerogative of the nuclear operator. Such an approach is not unique to Ukraine. Any change in the supply of fuel to a nuclear power plant requires careful safety assessment and testing. Any such modifications should be approved by the national regulatory body in accordance with national laws, applicable safety regulations and industry best practices.''. (author)

  16. Dried influenza vaccines : Over the counter vaccines

    NARCIS (Netherlands)

    Saluja, Vinay; Hinrichs, Wouter L. J.; Frijlink, Henderik W.

    2010-01-01

    Since last year influenza pandemic has struck again after 40 years, this is the right moment to discuss the different available formulation options for influenza vaccine. Looking back to the last 4 decades, most vaccines are still formulated as liquid solution. These vaccines have shown a poor

  17. Stories of change in drug treatment

    DEFF Research Database (Denmark)

    Andersen, Ditte

    2015-01-01

    ’ (story content) and ‘the hows’ (storying process) the article presents four findings: (1) stories of change function locally as an institutional requirement; (2) professional drug treatment providers edit young people's storytelling through different techniques; (3) the narrative environment of the drug...... treatment. Building on the sociology of storytelling and ethnographic fieldwork conducted at two drug treatment institutions for young people in Denmark, this article argues that studying stories in the context of their telling brings forth novel insights. Through a narrative analysis of both ‘the whats...... treatment institution shapes how particular stories make sense of the past, present and future; and (4) storytelling in drug treatment is an interactive achievement. A fine-grained analysis illuminates in particular how some stories on gender and drug use are silenced, while others are encouraged...

  18. Argument Strength and the Persuasiveness of Stories

    Science.gov (United States)

    Schreiner, Constanze; Appel, Markus; Isberner, Maj-Britt; Richter, Tobias

    2017-01-01

    ABSTRACT Stories are a powerful means to change people’s attitudes and beliefs. The aim of the current work was to shed light on the role of argument strength (argument quality) in narrative persuasion. The present study examined the influence of strong versus weak arguments on attitudes in a low or high narrative context. Moreover, baseline attitudes, interindividual differences in working memory capacity, and recipients’ transportation were examined. Stories with strong arguments were more persuasive than stories with weak arguments. This main effect was qualified by a two-way interaction with baseline attitude, revealing that argument strength had a greater impact on individuals who initially were particularly doubtful toward the story claim. Furthermore, we identified a three-way interaction showing that argument strength mattered most for recipients who were deeply transported into the story world in stories that followed a typical narrative structure. These findings provide an important specification of narrative persuasion theory. PMID:29805322

  19. The Role of Episodic Structure and of Story Length in Children's Recall of Simple Stories

    Science.gov (United States)

    Glenn, Christine G.

    1978-01-01

    It was hypothesized that if the episodic structure of a story determines subjects' organization of that story in memory, then variation in structure should affect the organization of information in recall. (Author/NCR)

  20. Story and recall in first person shooters

    OpenAIRE

    Pinchbeck, Dan

    2008-01-01

    Story has traditionally been seen as something separate to gameplay—frequently relegated to an afterthought or epiphenomenon. Nevertheless, in the FPS genre there has been something of a renaissance in the notion of the story-driven title. Partially, this is due to advances in technology enabling a greater capacity for distributed storytelling and a better integration of story and gameplay. However, what has been underrecognised is the dynamic, epistemological, and psychological impact of sto...

  1. Vaccines and Pregnancy

    Science.gov (United States)

    ... high or when infection would pose a high risk to the mother or baby, vaccination with a live vaccine is discussed. If there ... and benefits. For some diseases the benefit of vaccination outweighs any risks that may be associated with the vaccine. What ...

  2. History of vaccination.

    Science.gov (United States)

    Plotkin, Stanley

    2014-08-26

    Vaccines have a history that started late in the 18th century. From the late 19th century, vaccines could be developed in the laboratory. However, in the 20th century, it became possible to develop vaccines based on immunologic markers. In the 21st century, molecular biology permits vaccine development that was not possible before.

  3. History of vaccination

    OpenAIRE

    Plotkin, Stanley

    2014-01-01

    Vaccines have a history that started late in the 18th century. From the late 19th century, vaccines could be developed in the laboratory. However, in the 20th century, it became possible to develop vaccines based on immunologic markers. In the 21st century, molecular biology permits vaccine development that was not possible before.

  4. Automated Story Capture From Conversational Speech

    National Research Council Canada - National Science Library

    Gordon, Andrew S; Ganesan, Kavita

    2005-01-01

    While storytelling has long been recognized as an important part of effective knowledge management in organizations, knowledge management technologies have generally not distinguished between stories...

  5. Using life story work to enhance care.

    Science.gov (United States)

    Thompson, Rachel

    2011-10-01

    Life story work has been promoted as a tool to enhance the care provided to older people, particularly those with dementia. The benefits for individuals, families and/or friends and for staff include improving understanding of the individual, promoting relationships and assisting in the delivery of person-centred care. However, professionals often experience difficulties using life story work. This article considers a range of life story tools and advice on gathering information about a person. It highlights the importance of leadership and developing positive cultures to ensure that life story work can be effectively sustained.

  6. Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe.

    Directory of Open Access Journals (Sweden)

    Thomas F Müller

    Full Text Available In Europe, the elimination of wildlife rabies using oral rabies vaccination [ORV] of foxes for more than 30 years has been a success story. Since a comprehensive review on the scope of the different oral rabies vaccine baits distributed across Europe has not been available yet, we evaluated the use of different vaccine baits over the entire period of ORV [1978-2014]. Our findings provide valuable insights into the complexity of ORV programs in terms of vaccine related issues. More than 10 oral vaccines against rabies were used over the past four decades. Depending on many factors, the extent to which oral rabies virus vaccines were used varied considerably resulting in huge differences in the number of vaccine doses disseminated in ORV campaigns as well as in large spatial and temporal overlaps. Although vaccine virus strains derived from the SAD rabies virus isolate were the most widely used, the success of ORV campaigns in Europe cannot be assigned to a single oral rabies virus vaccine alone. Rather, the successful elimination of fox rabies is the result of an interaction of different key components of ORV campaigns, i.e. vaccine strain, vaccine bait and strategy of distribution.

  7. Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe

    Science.gov (United States)

    Müller, Thomas F.; Schröder, Ronald; Wysocki, Patrick; Mettenleiter, Thomas C.; Freuling, Conrad M.

    2015-01-01

    In Europe, the elimination of wildlife rabies using oral rabies vaccination [ORV] of foxes for more than 30 years has been a success story. Since a comprehensive review on the scope of the different oral rabies vaccine baits distributed across Europe has not been available yet, we evaluated the use of different vaccine baits over the entire period of ORV [1978–2014]. Our findings provide valuable insights into the complexity of ORV programs in terms of vaccine related issues. More than 10 oral vaccines against rabies were used over the past four decades. Depending on many factors, the extent to which oral rabies virus vaccines were used varied considerably resulting in huge differences in the number of vaccine doses disseminated in ORV campaigns as well as in large spatial and temporal overlaps. Although vaccine virus strains derived from the SAD rabies virus isolate were the most widely used, the success of ORV campaigns in Europe cannot be assigned to a single oral rabies virus vaccine alone. Rather, the successful elimination of fox rabies is the result of an interaction of different key components of ORV campaigns, i.e. vaccine strain, vaccine bait and strategy of distribution. PMID:26280895

  8. Mexico introduces pentavalent vaccine.

    Science.gov (United States)

    1999-08-01

    Combination vaccines have been introduced in Mexico. The national immunization program has incorporated the measles-mumps-rubella (MMR) vaccines in 1998, and the pentavalent vaccine in 1999. The two categories of antigen composition in combination vaccines are: 1) multiple different antigenic types of a single pathogen, such as the 23 valent pneumococcal polysaccharide vaccine, and 2) antigens from different pathogens causing different diseases, such as the DPT and MMR vaccines. Pentavalent vaccines are included in the second category. The vaccine protects against diphtheria, tetanus, pertussis, hepatitis B, and other diseases produced by Haemophilus influenzae type b (Hib). Combined diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenza type b (DTP-HB/Hib) vaccine has been distributed to 87% of Mexican children under 1 year of age. Over 800,000 doses of pentavalent vaccine have been administered.

  9. More than pretty pictures? How illustrations affect parent-child story reading and children's story recall

    Science.gov (United States)

    Greenhoot, Andrea Follmer; Beyer, Alisa M.; Curtis, Jennifer

    2014-01-01

    Previous research showed that story illustrations fail to enhance young preschoolers' memories when they accompany a pre-recorded story (e.g., Greenhoot and Semb, 2008). In this study we tested whether young children might benefit from illustrations in a more interactive story-reading context. For instance, illustrations might influence parent-child reading interactions, and thus children's story comprehension and recall. Twenty-six 3.5- to 4.5-year-olds and their primary caregivers were randomly assigned to an Illustrated or Non-Illustrated story-reading condition, and parents were instructed to “read or tell the story” as they normally would read with their child. Children recalled the story after a distracter and again after 1 week. Analyses of the story-reading interactions showed that the illustrations prompted more interactive story reading and more parent and child behaviors known to predict improved literacy outcomes. Furthermore, in the first memory interview, children in the Illustrated condition recalled more story events than those in the Non-Illustrated condition. Story reading measures predicted recall, but did not completely account for picture effects. These results suggest that illustrations enhance young preschoolers' story recall in an interactive story reading context, perhaps because the joint attention established in this context supports children's processing of the illustrations. PMID:25101018

  10. Getting the story right: making computer-generated stories more entertaining

    NARCIS (Netherlands)

    Oinonen, K.M.; Theune, Mariet; Nijholt, Antinus; Heylen, Dirk K.J.; Maybury, Mark; Stock, Oliviero; Wahlster, Wolfgang

    2005-01-01

    In this paper we describe our efforts to increase the entertainment value of the stories generated by our story generation system, the Virtual Storyteller, at the levels of plot creation, discourse generation and spoken language presentation. We also discuss the construction of a story database that

  11. Surviving ICU: Stories of recovery.

    Science.gov (United States)

    Ewens, Beverley A; Hendricks, Joyce M; Sundin, Deborah

    2018-02-28

    The aim of this study was to investigate stories of recovery through the lens of intensive care unit (ICU) survivors. Survival from ICUs is increasing, as are associated physical and psychological complications. Despite the significant impact on survivors, there is inadequate support provision in Australia and world-wide for this population. An interpretive biographical approach of intensive care survivors' experiences of recovery. Data were collected during 2014-2015 from diaries, face to face interviews, memos and field notes. Six participants diarized for 3 months commencing 2 months after hospital discharge. At 5 months, participants were interviewed about the content of their diaries and symbols and signifiers in them to create a shared meaning. Analysis of diaries and interviews were undertaken using two frameworks to identify themes throughout participants' stories and provides a unique portrait of recovery through their individual lens. Participants considered their lives had irreparably changed and yet felt unsupported by a healthcare system that had "saved" them. This view through their lens identified turmoil, which existed between their surface and inner worlds as they struggled to conform to what recovery "should be". The novel biographical methods provided a safe and creative way to reveal survivors' inner thoughts and feelings. Participants' considered creating their stories supported their recovery process and in particular enabled them to reflect on their progress. Findings from this study may lead to increased awareness among health care providers about problems survivors face and improved support services more broadly, based on frameworks appropriate for this population. © 2018 John Wiley & Sons Ltd.

  12. Vaccines today, vaccines tomorrow: a perspective.

    Science.gov (United States)

    Loucq, Christian

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles Mérieux are known among experts only despite their contribution to global health. Thanks to a vaccine, smallpox has been eradicated, polio has nearly disappeared, Haemophilus influenzae B, measles and more recently meningitis A are controlled in many countries. While a malaria vaccine is undergoing phase 3, International Vaccine Institute, in collaboration with an Indian manufacturer has brought an oral inactivated cholera vaccine to pre-qualification. The field of vaccinology has undergone major changes thanks to philanthropists such as Bill and Melinda Gates, initiatives like the Decade of Vaccines and public private partnerships. Current researches on vaccines have more challenging targets like the dengue viruses, malaria, human immunodeficiency virus, the respiratory syncytial virus and nosocomial diseases. Exciting research is taking place on new adjuvants, nanoparticles, virus like particles and new route of administration. An overcrowded infant immunization program, anti-vaccine groups, immunizing a growing number of elderlies and delivering vaccines to difficult places are among challenges faced by vaccinologists and global health experts.

  13. Control: China Story Yearbook 2016

    OpenAIRE

    2017-01-01

    ‘More cosmopolitan, more lively, more global’ is how the China Daily summed up the year 2016 in China. It was also a year of more control. The Chinese Communist Party laid down strict new rules of conduct for its members, continued to assert its dominance over everything from the Internet to the South China Sea and announced a new Five-Year Plan that Greenpeace called ‘quite possibly the most important document in the world in setting the pace of acting on climate change’. The China Story Y...

  14. Oral vaccination of fish

    OpenAIRE

    Embregts, Carmen W.E.; Forlenza, Maria

    2016-01-01

    The limited number of oral vaccines currently approved for use in humans and veterinary species clearly illustrates that development of efficacious and safe oral vaccines has been a challenge not only for fish immunologists. The insufficient efficacy of oral vaccines is partly due to antigen breakdown in the harsh gastric environment, but also to the high tolerogenic gut environment and to inadequate vaccine design. In this review we discuss current approaches used to develop oral vaccines fo...

  15. Varicella and herpes zoster vaccine development: lessons learned.

    Science.gov (United States)

    Warren-Gash, Charlotte; Forbes, Harriet; Breuer, Judith

    2017-12-01

    Before vaccination, varicella zoster virus (VZV), which is endemic worldwide, led to almost universal infection. This neurotropic virus persists lifelong by establishing latency in sensory ganglia, where its reactivation is controlled by VZV-specific T-cell immunity. Lifetime risk of VZV reactivation (zoster) is around 30%. Vaccine development was galvanised by the economic and societal burden of VZV, including debilitating zoster complications that largely affect older individuals. Areas covered: We describe the story of development, licensing and implementation of live attenuated vaccines against varicella and zoster. We consider the complex backdrop of VZV virology, pathogenesis and immune responses in the absence of suitable animal models and examine the changing epidemiology of VZV disease. We review the vaccines' efficacy, safety, effectiveness and coverage using evidence from trials, observational studies from large routine health datasets and clinical post-marketing surveillance studies and outline newer developments in subunit and inactivated vaccines. Expert commentary: Safe and effective, varicella and zoster vaccines have already made major inroads into reducing the burden of VZV disease globally. As these live vaccines have the potential to reactivate and cause clinical disease, developing alternatives that do not establish latency is an attractive prospect but will require better understanding of latency mechanisms.

  16. Typhoid fever vaccination strategies.

    Science.gov (United States)

    Date, Kashmira A; Bentsi-Enchill, Adwoa; Marks, Florian; Fox, Kimberley

    2015-06-19

    Typhoid vaccination is an important component of typhoid fever prevention and control, and is recommended for public health programmatic use in both endemic and outbreak settings. We reviewed experiences with various vaccination strategies using the currently available typhoid vaccines (injectable Vi polysaccharide vaccine [ViPS], oral Ty21a vaccine, and injectable typhoid conjugate vaccine [TCV]). We assessed the rationale, acceptability, effectiveness, impact and implementation lessons of these strategies to inform effective typhoid vaccination strategies for the future. Vaccination strategies were categorized by vaccine disease control strategy (preemptive use for endemic disease or to prevent an outbreak, and reactive use for outbreak control) and vaccine delivery strategy (community-based routine, community-based campaign and school-based). Almost all public health typhoid vaccination programs used ViPS vaccine and have been in countries of Asia, with one example in the Pacific and one experience using the Ty21a vaccine in South America. All vaccination strategies were found to be acceptable, feasible and effective in the settings evaluated; evidence of impact, where available, was strongest in endemic settings and in the short- to medium-term. Vaccination was cost-effective in high-incidence but not low-incidence settings. Experience in disaster and outbreak settings remains limited. TCVs have recently become available and none are WHO-prequalified yet; no program experience with TCVs was found in published literature. Despite the demonstrated success of several typhoid vaccination strategies, typhoid vaccines remain underused. Implementation lessons should be applied to design optimal vaccination strategies using TCVs which have several anticipated advantages, such as potential for use in infant immunization programs and longer duration of protection, over the ViPS and Ty21a vaccines for typhoid prevention and control. Copyright © 2015. Published by

  17. Books and Stories in Children's Science

    Science.gov (United States)

    McCullagh, John; Walsh, Glenda; Greenwood, Julian

    2010-01-01

    A group of third-year undergraduate student teachers used books and stories during science enquiry lessons as part of the BASICS (Books And Stories In Children's Science) project funded by the AstraZeneca Science Teaching Trust. This three-year project involved a cluster of five primary schools in the greater Belfast area. The aim of the project…

  18. Bedtime stories : weaving traditions into digital technologies

    NARCIS (Netherlands)

    Kuusk, K.; Tomico, O.; Langereis, G.R.

    2013-01-01

    Bedtime Stories is a proposal for a long-lasting - environmentally, economically and societally sustainable smart textile service. It is a set of woven bed linen with images that can be recognized by a custom made fairy-tale application. This new way of story creation is an opportunity to share

  19. AHP 10: Story: A Stolen Journey

    Directory of Open Access Journals (Sweden)

    Blo bzang tshe ring བློ་བཟང་ཚེ་རིང་།

    2011-06-01

    Full Text Available BIo bzang tshe ring (b 1984 is from A mgon Village, A mchog Town, Bsang chu County, Kan Iho Tibetan Autonomous Prefecture, Kan su'u Province. He says, "I wrote this story based on what I was told by the three men who brought the main character of the story to Zi ling City in their car."

  20. Famous Threesomes: Uncommon Uses for Common Stories.

    Science.gov (United States)

    Spears, Jo Ann Lohl

    2003-01-01

    This article presents a unit of fun and developmentally satisfying activities, using familiar folk stories focusing on threesomes. Each example involves story time, block center, art center, dramatic play, listening area, math and manipulatives center, folder game, group times, cooking, writing center, discovery center, and the music and movement…

  1. Fast Moccasin: A Story of Arapaho Kinship.

    Science.gov (United States)

    Woodenlegs, Martha

    The story of Fast Moccasin, a 14-year-old Arapaho youth anxiously awaiting the annual Arapaho Pow-wow, is used to portray the kinship relationships of the Arapaho. Following the story is a 30-item quiz concerning relationships or relationship equivalents (blood relations, extended families, adopted families), naming procedures, and courtesies…

  2. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 11:08 Mia Tatun - Albany Medical Center Children's Hospital - Journeys Palliative Care Story - Duration: 3:32. ... 4:01 Mitochondrial Disease Patient Story - Cleveland Clinic Children's Hospital - Duration: 4:17. Cleveland Clinic 82,065 ...

  3. Better Buildings Neighborhood Program Progress Stories

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-04-19

    n neighborhoods across the country, stories are emerging constantly of individuals, businesses, and organizations that are benefiting from energy efficiency. Included are the stories of real people making their homes, businesses, and communities better with the help of the Better Buildings Neighborhood Program.

  4. Migrant life stories and the Web

    DEFF Research Database (Denmark)

    Marselis, Randi

    2013-01-01

    The life stories of migrants are increasingly being told, as part of the work of cultural organizations, and websites are well suited to making such life story projects accessible to the public. However, by using the lives of real people as raw material in a public forum, Web projects raise...

  5. Story Map: How to Improve Writing Skills

    Science.gov (United States)

    Sidekli, Sabri

    2013-01-01

    The aim of written expression studies is to have students explain their knowledge, feelings, ideas and imaginations in a correct and effective manner. Therefore, the purpose of this study is to investigate the effect of story map on story writing skills of first grade teacher candidates who study at the Department of Elementary Education. The…

  6. Regionalization: A Story Map Lesson on Regions

    Science.gov (United States)

    Edmondson, Deborah

    2018-01-01

    This lesson introduces the concept of regionalization and types of regions. After a brief introductory activity, students explore a story map to learn the material. The teacher can project the story map on a screen for all students to follow or students may work individually on computers. Working individually will allow students to set their own…

  7. Rabbi: exploring the inner world through stories

    Energy Technology Data Exchange (ETDEWEB)

    Umaschi, M. [MIT Media Lab., Cambridge, MA (United States)

    1996-12-31

    In the oral tradition, stories were told by the elder sages in order to give indirect advice. Today most stories are told in order to entertain. While some research on storytelling systems has focused on drama/theater metaphors and adventure/mystery simulation games, my research emphasizes the counseling and self-awareness possibilities of storytelling.

  8. Telling Stories: Past and Present Heroes

    Science.gov (United States)

    Smith, Colin Bridges

    2007-01-01

    Among the Xhosa tribe in South Africa storytelling is a magnificent art. But these stories are more than mere entertainment. Xhosa scholar Harold Scheub says story-telling for the Xhosa people is "not only a primary means of entertainment and artistic expression in the society, it is also the major educational device." Beyond education,…

  9. Vaccines: an ongoing promise?

    Science.gov (United States)

    Alsahli, M; Farrell, R J; Michetti, P

    2001-01-01

    Over the past decade, intensive research has focused on developing a vaccine therapy for Helicobacter pylori. Substantial unresolved questions cloud the current approach, and the development of a vaccine against this unique organism has proved very challenging. Many candidate vaccines have been tested in animal models. The immunogenicity and the safety of some vaccine formulations have been recently evaluated through clinical trials, and the efficacy of these vaccine therapies in humans will be determined in the near future. This article will provide an overview of the current knowledge of natural and vaccine-induced immune responses to H. pylori infection. It will also review past vaccine successes and failures in animal models and the limited experience to date in using vaccine therapy in humans. Several obstacles to H. pylori vaccine development efforts along with the future direction of these efforts will be discussed. Copyright 2001 S. Karger AG, Basel

  10. An Analysis on Effects of Story Mapping in Writing Short Stories in EFL Classes, Iraqi Case

    Directory of Open Access Journals (Sweden)

    Emine Bala

    2017-06-01

    Full Text Available In this study, it is investigated that how much story map graphic organizers contribute to foster writing short stories. Eighteen EFL students from foundation year were randomly chosen and provided eight writing courses. First, the writing teacher provided a topic to the students for each course, and asked them to write three short stories about given topics. In the following two lessons, the instructor introduced graphic organizers and taught the elements of short story to the students. Later, they were given another three topics for the following three courses to create short stories using story map graphic organizers created by writing teacher. Then, the researcher selected two of their first and second pieces randomly and developed a scale to assess the students’ first and second products. The results were classified by including story elements.in two tables as percentage.

  11. Neurologic complications of vaccinations.

    Science.gov (United States)

    Miravalle, Augusto A; Schreiner, Teri

    2014-01-01

    This chapter reviews the most common neurologic disorders associated with common vaccines, evaluates the data linking the disorder with the vaccine, and discusses the potential mechanism of disease. A literature search was conducted in PubMed using a combination of the following terms: vaccines, vaccination, immunization, and neurologic complications. Data were also gathered from publications of the American Academy of Pediatrics Committee on Infectious Diseases, the World Health Organization, the US Centers for Disease Control and Prevention, and the Vaccine Adverse Event Reporting System. Neurologic complications of vaccination are rare. Many associations have been asserted without objective data to support a causal relationship. Rarely, patients with a neurologic complication will have a poor outcome. However, most patients recover fully from the neurologic complication. Vaccinations have altered the landscape of infectious disease. However, perception of risk associated with vaccinations has limited the success of disease eradication measures. Neurologic complications can be severe, and can provoke fear in potential vaccines. Evaluating whether there is causal link between neurologic disorders and vaccinations, not just temporal association, is critical to addressing public misperception of risk of vaccination. Among the vaccines available today, the cost-benefit analysis of vaccinations and complications strongly argues in favor of vaccination. © 2014 Elsevier B.V. All rights reserved.

  12. Telling business stories as fellowship-tales

    DEFF Research Database (Denmark)

    Smith, Robert; Neergaard, Helle

    2015-01-01

    Purpose – This paper aims to explore the “Fellowship-Tale” as an alternative tale type for narrating entrepreneur stories. The authors illustrate this by telling the Pilgrim business story. It is common for the deeds of men who founded businesses to be narrated as heroic entrepreneur stories...... – The research indicates that “fellowship-tales” provide a viable and credible alternative to the fairy-tale rendition common in entrepreneur and business stories. Research limitations/implications – An obvious limitation is that one merely swaps one narrative framework for another, albeit it offers dissenting...... voices a real choice. Practical implications – This study has the potential to be far reaching because at a practical level, it allows disengaged entrepreneurs and significant others the freedom to exercise their individual and collective voices within a framework of nested stories. Originality...

  13. morfology of lyric storis of shahname

    Directory of Open Access Journals (Sweden)

    zeynab arabnejad

    2016-09-01

    Full Text Available An important part of parsian literature is composed under the name of lyric genre.The subject of lyric gener is generally love or human feeling.we are about to study structure orformology of Shahname s stories on the basis of Prop method to understand are they following same structure or not? and what is the influence of epic genre on lyric themes on composing thos stories. to study the influence of epic on the forms of stories we will investigate the fictional elements. to do that we choose these storie: Zal and Rodabe,Rostam and Tahmine,Bijan and Manije,Sodabe and Siyavash. Key words:lyric stories, Shahname, epic, morfology

  14. Explaining the moral of the story.

    Science.gov (United States)

    Walker, Caren M; Lombrozo, Tania

    2017-10-01

    Although storybooks are often used as pedagogical tools for conveying moral lessons to children, the ability to spontaneously extract "the moral" of a story develops relatively late. Instead, children tend to represent stories at a concrete level - one that highlights surface features and understates more abstract themes. Here we examine the role of explanation in 5- and 6-year-old children's developing ability to learn the moral of a story. Two experiments demonstrate that, relative to a control condition, prompts to explain aspects of a story facilitate children's ability to override salient surface features, abstract the underlying moral, and generalize that moral to novel contexts. In some cases, generating an explanation is more effective than being explicitly told the moral of the story, as in a more traditional pedagogical exchange. These findings have implications for moral comprehension, the role of explanation in learning, and the development of abstract reasoning in early childhood. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Beijing Bicycle - Stories from a Transformative Space

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2012-01-01

    Ideas, words, images and stories travel from west to east – and from east to west. Stories are chosen and retold in different settings and images are reproduced and appropriated into new contexts – and in new times. Cinema, in this case the mainland Chinese, becomes both a space of production...... and a production of space that reveals how transnational and translocal mechanisms affect the cinematic language, transforming the images and stories chosen for the cinematic representation. Wang Xiaoshuai’s Beijing Bicycle (Shiqi Sui de Danche) (2001) is a result of transnational currents weaving the carpet...... relevant in a new context – that of the Chinese mainland society in the 21st century. Doreen Massey (2005: 9) defines space as “a simultaneity of stories-so-far”, a space that is constantly exploding and imploding with the influx of new and old stories. Within this theoretical framework Wang Xiaoshuai...

  16. Dental stories for children with autism.

    Science.gov (United States)

    Marion, Ian W; Nelson, Travis M; Sheller, Barbara; McKinney, Christy M; Scott, JoAnna M

    2016-07-01

    To investigate caregivers' preference regarding dental stories to prepare children with autism for dental visits. Caregivers of children with autism were allowed use of dental stories available via different media (paper, tablet computer, computer) and image types (comics or drawings, photographs, video). Caregivers completed pre- and postintervention surveys. Fisher's exact tests were used to determine associations between predictive factors and preferences. Forty initial and 16 follow-up surveys were completed. Subjects were primarily male (85%). Mean child age was 6.7 years. Nine (64%) caregivers found the dental story useful for themselves and their child. Two (14%) caregivers found the aid only helpful for themselves. Preferred media type was associated with language understanding (p = .038) and home media preference (p = .002). Practitioners should consider using dental stories to help prepare families and children for dental visits. Individual preferences for dental stories vary; using prior history can aid in selection. © 2016 Special Care Dentistry Association and Wiley Periodicals, Inc.

  17. Current Vaccine Shortages and Delays

    Science.gov (United States)

    ... Hepatitis A vaccine supply in the US. Updated Mar 2018 Note 2 : Pediatric hepatitis B vaccine: Merck ... Submitted, Licensed, and Recommended Vaccines & Biologics Red Book® Online Influenza Vaccination Recommendations Childhood & Adolescent Immunization Schedules Adult ...

  18. Vaccine-Preventable Disease Photos

    Science.gov (United States)

    ... Work Importance of Vaccines Paying for Vaccines State Immunization Programs Tips for Finding Vaccine Records Trusted Sources of ... efficacy, and use of vaccines within the broad immunization community of patients, parents, healthcare organizations, and government health agencies.

  19. Vaccines against poverty

    Science.gov (United States)

    MacLennan, Calman A.; Saul, Allan

    2014-01-01

    With the 2010s declared the Decade of Vaccines, and Millennium Development Goals 4 and 5 focused on reducing diseases that are potentially vaccine preventable, now is an exciting time for vaccines against poverty, that is, vaccines against diseases that disproportionately affect low- and middle-income countries (LMICs). The Global Burden of Disease Study 2010 has helped better understand which vaccines are most needed. In 2012, US$1.3 billion was spent on research and development for new vaccines for neglected infectious diseases. However, the majority of this went to three diseases: HIV/AIDS, malaria, and tuberculosis, and not neglected diseases. Much of it went to basic research rather than development, with an ongoing decline in funding for product development partnerships. Further investment in vaccines against diarrheal diseases, hepatitis C, and group A Streptococcus could lead to a major health impact in LMICs, along with vaccines to prevent sepsis, particularly among mothers and neonates. The Advanced Market Commitment strategy of the Global Alliance for Vaccines and Immunisation (GAVI) Alliance is helping to implement vaccines against rotavirus and pneumococcus in LMICs, and the roll out of the MenAfriVac meningococcal A vaccine in the African Meningitis Belt represents a paradigm shift in vaccines against poverty: the development of a vaccine primarily targeted at LMICs. Global health vaccine institutes and increasing capacity of vaccine manufacturers in emerging economies are helping drive forward new vaccines for LMICs. Above all, partnership is needed between those developing and manufacturing LMIC vaccines and the scientists, health care professionals, and policy makers in LMICs where such vaccines will be implemented. PMID:25136089

  20. The origins of the vaccine cold chain and a glimpse of the future.

    Science.gov (United States)

    Lloyd, John; Cheyne, James

    2017-04-19

    International efforts to eradicate smallpox in the 1960s and 1970s provided the foundation for efforts to expand immunization programmes, including work to develop immunization supply chains. The need to create a reliable system to keep vaccines cold during the lengthy journey from the manufacturer to the point of use, even in remote areas, was a crucial concern during the early days of the Expanded Programme on Immunization. The vaccine cold chain was deliberately separated from other medical distribution systems to assure timely access to and control of vaccines and injection materials. The story of the early development of the vaccine cold chain shows how a number of challenges were overcome with technological and human resource solutions. For example, the lack of methods to monitor exposure of vaccines to heat during transport and storage led to many innovations, including temperature-sensitive vaccine vial monitors and better methods to record and communicate temperatures in vaccine stores. The need for appropriate equipment to store and transport vaccines in tropical developing countries led to innovations in refrigeration equipment as well as the introduction and widespread adoption of novel high performance vaccine cold-boxes and carriers. New technologies also helped to make injection safer. Underlying this work on technologies and equipment was a major effort to develop the human resources required to manage and implement the immunization supply chain. This included creating foundational policies and a management infrastructure; providing training for managers, health workers, technicians, and others. The vaccine cold chain has contributed to one of the world's public health success stories and provides three priority lessons for future: the vaccine supply chain needs to be integrated with other public health supplies, re-designed for efficiency and effectiveness and work is needed in the longer term to eliminate the need for refrigeration in the supply

  1. Vaccine Associated Myocarditis

    Directory of Open Access Journals (Sweden)

    Johnson Francis

    2017-04-01

    Full Text Available Most of the cases of vaccine associated myocarditis have been following small pox vaccination. Reports have also been there after streptococcal pneumonia vaccine and influenza vaccine. In some cases, autoimmune/inflammatory syndrome induced by adjuvants (ASIA used in the vaccine have been implicated. Exclusion of other causes is very important in the diagnostic process, especially that of acute coronary syndrome. Management is similar to that of other etiologies of myocarditis. These rare instances of myocarditis should not preclude one from taking necessary immunization for vaccine preventable diseases.

  2. Vaccines and Immunization Practice.

    Science.gov (United States)

    Hogue, Michael D; Meador, Anna E

    2016-03-01

    Vaccines are among most cost-effective public health strategies. Despite effective vaccines for many bacterial and viral illnesses, tens of thousands of adults and hundreds of children die each year in the United States from vaccine-preventable diseases. Underutilization of vaccines requires rethinking the approach to incorporating vaccines into practice. Arguably, immunizations could be a part all health care encounters. Shared responsibility is paramount if deaths are to be reduced. This article reviews the available vaccines in the US market, as well as practice recommendations of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Neutralising antibody response in domestic cats immunised with a commercial feline immunodeficiency virus (FIV) vaccine.

    Science.gov (United States)

    Bęczkowski, Paweł M; Harris, Matthew; Techakriengkrai, Navapon; Beatty, Julia A; Willett, Brian J; Hosie, Margaret J

    2015-02-18

    Across human and veterinary medicine, vaccines against only two retroviral infections have been brought to market successfully, the vaccines against feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV). FeLV vaccines have been a global success story, reducing virus prevalence in countries where uptake is high. In contrast, the more recent FIV vaccine was introduced in 2002 and the degree of protection afforded in the field remains to be established. However, given the similarities between FIV and HIV, field studies of FIV vaccine efficacy are likely to advise and inform the development of future approaches to HIV vaccination. Here we assessed the neutralising antibody response induced by FIV vaccination against a panel of FIV isolates, by testing blood samples collected from client-owned vaccinated Australian cats. We examined the molecular and phenotypic properties of 24 envs isolated from one vaccinated cat that we speculated might have become infected following natural exposure to FIV. Cats vaccinated against FIV did not display broadly neutralising antibodies, suggesting that protection may not extend to some virulent recombinant strains of FIV circulating in Australia. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. Vaccines today, vaccines tomorrow: a perspective

    OpenAIRE

    Loucq, Christian

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles M?rieux are known among experts only despite their contribution to global hea...

  5. The perfect shape spiral stories

    CERN Document Server

    Hammer, Øyvind

    2016-01-01

    This book uses the spiral shape as a key to a multitude of strange and seemingly disparate stories about art, nature, science, mathematics, and the human endeavour. In a way, the book is itself organized as a spiral, with almost disconnected chapters circling around and closing in on the common theme. A particular strength of the book is its extremely cross-disciplinary nature - everything is fun, and everything is connected! At the same time, the author puts great emphasis on mathematical and scientific correctness, in contrast, perhaps, with some earlier books on spirals. Subjects include the mathematical properties of spirals, sea shells, sun flowers, Greek architecture, air ships, the history of mathematics, spiral galaxies, the anatomy of the human hand, the art of prehistoric Europe, Alfred Hitchcock, and spider webs, to name a few.

  6. Classical Cosmology Through Animation Stories

    Science.gov (United States)

    Mijic, Milan; Kang, E. Y. E.; Longson, T.; State LA SciVi Project, Cal

    2010-05-01

    Computer animations are a powerful tool for explanation and communication of ideas, especially to a younger generation. Our team completed a three part sequence of short, computer animated stories about the insight and discoveries that lead to the understanding of the overall structure of the universe. Our principal characters are Immanuel Kant, Henrietta Leavitt, and Edwin Hubble. We utilized animations to model and visualize the physical concepts behind each discovery and to recreate the characters, locations, and flavor of the time. The animations vary in length from 6 to 11 minutes. The instructors or presenters may wish to utilize them separately or together. The animations may be used for learning classical cosmology in a visual way in GE astronomy courses, in pre-college science classes, or in public science education setting.

  7. The Story of the Universe

    CERN Multimedia

    CMS Outreach

    2003-01-01

    These pages were extracted from the 2003 CMS Experiment Brochure. These pages explain the story of our universe and how it was formed over time. All explanations are coupled with simple colorful illustrations, one per sheet. Each can be used as an individual teaching aid or together as a set. Topics covered: - Quantum Gravity Era- Grand Unification Era - Electro Weak Era - Protons and Neutrons Formation- Nuclei formation- Atoms and Light Era - Galaxy Formation - Today Humans wondering where this all came from- The Size of Things - Instruments and the observables- Particles (Leptons & Quarks) -Forces - Interactions: coupling of forces to matter - Short history and new frontiers - Unification of forces - Summary (includes timeline of theories/discoveries)

  8. Vaccines Through Centuries: Major Cornerstones of Global Health

    Directory of Open Access Journals (Sweden)

    Inaya eHajj Hussein

    2015-11-01

    Full Text Available Multiple cornerstones have shaped the history of vaccines, which may contain live attenuated viruses, inactivated organisms/viruses, inactivated toxins, or merely segments of the pathogen that could elicit an immune response.The story began with Hippocrates 400 B.C. with his description of mumps and diphtheria. No further discoveries were recorded until 1100 A.D. when the smallpox vaccine was described. During the 18th century, vaccines for cholera and yellow fever were reported and Edward Jenner, the father of vaccination and immunology, published his work on small pox.The 19th century was a major landmark, with the Germ Theory of disease of Louis Pasteur, the discovery of the germ tubercle bacillus for tuberculosis by Robert Koch, and the isolation of pneumococcus organism by George Miller Sternberg. Another landmark was the discovery of diphtheria toxin by Emile Roux and its serological treatment by Emil Von Behring and Paul Ehrlih. In addition, Pasteur was able to generate the first live attenuated viral vaccine against rabies. Typhoid vaccines were then developed, followed by the plague vaccine of Yersin. At the beginning of World War I, the tetanus toxoid was introduced, followed in 1915 by the pertussis vaccine. In 1974, The Expanded Program of Immunization was established within the WHO for BCG, Polio, DTP, measles, yellow fever and hepatitis B. The year 1996 witnessed the launching of the International AIDS Vaccine Initiative. In 1988, the WHO passed a resolution to eradicate polio by the year 2000 and in 2006; the first vaccine to prevent cervical cancer was developed. In 2010 The Decade of vaccines was launched, and on April 1st 2012, the United Nations launched the shot@Life campaign. In brief, the armamentarium of vaccines continues to grow with more emphasis on safety, availability and accessibility. This mini review highlights the major historical events and pioneers in the course of development of vaccines, which have eradicated

  9. MMR Vaccine (Measles, Mumps, and Rubella)

    Science.gov (United States)

    Mumpsvax® Mumps Vaccine ... Biavax® II (as a combination product containing Mumps Vaccine, Rubella Vaccine) ... II (as a combination product containing Measles Vaccine, Mumps Vaccine, Rubella Vaccine)

  10. What is a Preventive HIV Vaccine?

    Science.gov (United States)

    ... Entire Series Related Content AIDSource | Vaccine Research HIV Vaccines History of HIV Vaccine Research Need Help? Call 1- ... Entire Series Related Content AIDSource | Vaccine Research HIV Vaccines History of HIV Vaccine Research Need Help? Call 1- ...

  11. Story asides as a useful construct in examining adults' story recall

    Science.gov (United States)

    Bluck, Susan; Alea, Nicole; Baron-Lee, Jacqueline M.; Davis, Danielle K.

    2016-01-01

    Older adults sometimes exhibit higher levels of off-target verbosity during story recall than do young adults. This appears as the inclusion of extraneous information not directly relevant to the topic. Some production of such material has been clearly related to cognitive decline, particularly older adults’ inability to inhibit production of irrelevant information. In tandem, however, research also suggests that some extraneous information is indirectly related to the topic and may reflect age differences in communicative styles. To further elucidate the social cognitive aspect of this issue, the question of import is: What is the content of the additional information provided by participants during story recall? The present study answers this question. Grounded in the autobiographical memory and life story literatures, we introduce the construct, story asides, and a reliable content-analytic scheme for its assessment. Young and older adults (N = 129) recalled one of two types of stories: a personal autobiographical memory or an experimenter-generated fictional story. Narratives were reliably coded for story asides. As expected, older adults produced more story asides than young adults only for autobiographical stories. The discussion focuses on the role of story asides in everyday communication including the possibility that they may be a sign of communicative expertise. PMID:26751005

  12. Story asides as a useful construct in examining adults' story recall.

    Science.gov (United States)

    Bluck, Susan; Alea, Nicole; Baron-Lee, Jacqueline M; Davis, Danielle K

    2016-02-01

    Older adults sometimes exhibit higher levels of off-target verbosity during story recall than do young adults. This appears as the inclusion of extraneous information not directly relevant to the topic. Some production of such material has been clearly related to cognitive decline, particularly older adults' inability to inhibit production of irrelevant information. In tandem, however, research also suggests that some extraneous information is indirectly related to the topic and may reflect age differences in communicative styles. To further elucidate the social-cognitive aspect of this issue, the question of import is: What is the content of the additional information provided by participants during story recall? The present study answers this question. Grounded in the autobiographical memory and life story literatures, we introduce the construct, story asides, and a reliable content-analytic scheme for its assessment. Young and older adults (N = 129) recalled 1 of 2 types of stories: a personal autobiographical memory or an experimenter-generated fictional story. Narratives were reliably coded for story asides. As expected, older adults produced more story asides than young adults only for autobiographical stories. The discussion focuses on the role of story asides in everyday communication including the possibility that they may be a sign of communicative expertise. (c) 2016 APA, all rights reserved).

  13. Ethical and legal challenges of vaccines and vaccination: Reflections.

    Science.gov (United States)

    Jesani, Amar; Johari, Veena

    2017-01-01

    Vaccines and vaccination have emerged as key medical scientific tools for prevention of certain diseases. Documentation of the history of vaccination shows that the initial popular resistance to universal vaccination was based on false assumptions and eventually gave way to acceptance of vaccines and trust in their ability to save lives. The successes of the global eradication of smallpox, and now of polio, have only strengthened the premier position occupied by vaccines in disease prevention. However, the success of vaccines and public trust in their ability to eradicate disease are now under challenge, as increasing numbers of people refuse vaccination, questioning the effectiveness of vaccines and the need to vaccinate.

  14. Holistic nurses' stories of healing of another.

    Science.gov (United States)

    Enzman Hines, Mary; Wardell, Diane Wind; Engebretson, Joan; Zahourek, Rothlyn; Smith, Marlaine C

    2015-03-01

    The purpose of this study was to uncover the essence and meaning of healing through narrative accounts of holistic nurses, using a qualitative, descriptive design integrating narrative and story inquiry. Twenty-five stories were collected. Seven stories revealed personal healing and have been published in a prior article. Eighteen stories, the focus of this analysis, revealed healing of another. A hybrid method blending narrative and story guided the overall process for the study. Nine themes emerged describing healing of another within three story segments: The Call to Healing, The Experience of Healing, and Insights. The theme within The Call to the Healing Encounter was Drawn by Compassion to the Vulnerability and/or Suffering of Another. Five themes describe the Experience of Healing: Connection: Cocreating Relationships; Taking Risks and Dealing With Skeptical Colleagues; Use of Modalities and Actions as Tools in Developing Self as an Instrument of Healing; Profound, Ineffable Events; and Using Metaphor and Rituals to Describe Healing. Three themes describe Insights: Mutual Transformation, Change, and Reciprocity; Gratitude for the Healing Encounter; and Leaving a Legacy. The metastory, a reconstructed story created by the researchers, was the final phase of research synthesizing and demonstrating themes of healing of another. Results were compared to existing healing literature. © The Author(s) 2014.

  15. RN students need to tell their stories.

    Science.gov (United States)

    Blecke, J; Flatt, M M

    1993-04-01

    Finally, what is it about RN students' experiences in the transition process in nursing education that makes their stories need to be told? Actually this question is asked from both the side of the RN students who are the learners and need to tell the stories, and the side of the educator/advisor who needs to have the stories told. In short, the answer to both is that these stories reveal very graphically and meaningfully what is happening in the learning and professional development processes and, simultaneously, they facilitate the progression of those processes. The RN students seem to have an innate sense about what telling their stories will do for them in relation to their learning and professional development processes. They require very little encouragement to prompt their story telling. For the educators/advisors, no other strategy is as adaptable and achieves as much in relation to facilitating the learning and development processes. For both parties, the graphic revelations in stories paint a picture of how past, present, and future blend together to form a meaningful, coherent view of a position in the world. According to Antonovsky's (1979) work on stress and coping, such a view is necessary if stress is to be resisted and health maintained.(ABSTRACT TRUNCATED AT 400 WORDS)

  16. An early story of Kho Ping Hoo

    Directory of Open Access Journals (Sweden)

    CW Watson

    2017-05-01

    Full Text Available Kho Ping Hoo (1926–1994 is the most well-known of all Indonesian writers of popular silat stories, largely set in China, which describe the adventures and romances of legendary heroes famed for their skill in martial arts. It is less well-known that he began his career writing critical stories about socio-economic conditions in the late 50s and early 60s. This paper discusses one of these stories. It places the story in the context of political developments of the time, in particular as they affected the Chinese Indonesian community. The paper argues that this story and one or two others like it come at the end of a tradition of Sino-Indonesian literature which had flourished from the end of the nineteenth century until the mid-1950s. After 1960, Chinese-Indonesian writers cease writing realist fiction of any kind and write either silat stories or romantic stories set in middle class urban environments.

  17. Laser facilitates vaccination

    Directory of Open Access Journals (Sweden)

    Ji Wang

    2016-01-01

    Full Text Available Development of novel vaccine deliveries and vaccine adjuvants is of great importance to address the dilemma that the vaccine field faces: to improve vaccine efficacy without compromising safety. Harnessing the specific effects of laser on biological systems, a number of novel concepts have been proposed and proved in recent years to facilitate vaccination in a safer and more efficient way. The key advantage of using laser technology in vaccine delivery and adjuvantation is that all processes are initiated by physical effects with no foreign chemicals administered into the body. Here, we review the recent advances in using laser technology to facilitate vaccine delivery and augment vaccine efficacy as well as the underlying mechanisms.

  18. Vaccine Safety Datalink

    Science.gov (United States)

    The Vaccine Safety Datalink is part of the National Immunization Program within the Centers for Disease Control and Prevention and was started in recognition of gaps in the scientific knowledge of rare vaccine side effects.

  19. The HPV Vaccination Crisis

    Science.gov (United States)

    Following the release of a consensus statement from the NCI-Designated Cancer Centers urging HPV vaccination in the United States, Dr. Noel Brewer discusses the country’s low vaccination rates and how clinicians can help to improve them.

  20. Your child's first vaccines

    Science.gov (United States)

    ... term seizures, coma, lowered consciousness, and permanent brain damage have been reported following DTaP vaccination. These reports are extremely rare. Pneumococcal Vaccine Mild Problems: drowsiness or temporary loss of appetite ( ...

  1. Your Baby's First Vaccines

    Science.gov (United States)

    ... term seizures, coma, lowered consciousness, and permanent brain damage have been reported following DTaP vaccination. These reports are extremely rare. Pneumococcal Vaccine Mild Problems: Drowsiness or temporary loss of appetite ( ...

  2. Vaccines in Multiple Sclerosis.

    Science.gov (United States)

    Williamson, Eric M L; Chahin, Salim; Berger, Joseph R

    2016-04-01

    Vaccinations help prevent communicable disease. To be valuable, a vaccine's ability to prevent disease must exceed the risk of adverse effects from administration. Many vaccines present no risk of infection as they are comprised of killed or non-infectious components while other vaccines consist of live attenuated microorganisms which carry a potential risk of infection-particularly, in patients with compromised immunity. There are several unique considerations with respect to vaccination in the multiple sclerosis (MS) population. First, there has been concern that vaccination may trigger or aggravate the disease. Second, disease-modifying therapies (DMTs) employed in the treatment of MS may increase the risk of infectious complications from vaccines or alter their efficacy. Lastly, in some cases, vaccination strategies may be part of the treatment paradigm in attempts to avoid complications of therapy.

  3. Vaccines and immunization

    African Journals Online (AJOL)

    Prof Ezechukwu

    vaccines for malaria and HIV infection. Despite the ... decades, effective vaccines against the major causes of ... challenge antibodies, specific helper and effector T lymphocytes ... materials to produced immunity to a disease. It was originally ...

  4. Pneumococcal Vaccines (PCV, PPSV)

    Science.gov (United States)

    ... Educators Search English Español Your Child's Immunizations: Pneumococcal Vaccines (PCV, PPSV) KidsHealth / For Parents / Your Child's Immunizations: ... cochlear implants. Why Are the PCV and PPSV Vaccines Recommended? Children younger than 2 years old, adults ...

  5. [Mumps vaccine virus transmission].

    Science.gov (United States)

    Otrashevskaia, E V; Kulak, M V; Otrashevskaia, A V; Karpov, I A; Fisenko, E G; Ignat'ev, G M

    2013-01-01

    In this work we report the mumps vaccine virus shedding based on the laboratory confirmed cases of the mumps virus (MuV) infection. The likely epidemiological sources of the transmitted mumps virus were children who were recently vaccinated with the mumps vaccine containing Leningrad-Zagreb or Leningrad-3 MuV. The etiology of the described cases of the horizontal transmission of both mumps vaccine viruses was confirmed by PCR with the sequential restriction analysis.

  6. Rotavirus vaccines: an overview.

    OpenAIRE

    Midthun, K; Kapikian, A Z

    1996-01-01

    Rotavirus vaccine development has focused on the delivery of live attenuated rotavirus strains by the oral route. The initial "Jennerian" approach involving bovine (RIT4237, WC3) or rhesus (RRV) rotavirus vaccine candidates showed that these vaccines were safe, well tolerated, and immunogenic but induced highly variable rates of protection against rotavirus diarrhea. The goal of a rotavirus vaccine is to prevent severe illness that can lead to dehydration in infants and young children in both...

  7. Ethnographic Stories as Generalizations that Intervene

    DEFF Research Database (Denmark)

    Winthereik, Brit Ross; Verran, Helen

    2012-01-01

    In this paper, we show why we think the notion of instrumental ethnography should be revived (compared to Steve Woolgar's 1982 use of the term). We see instrumental ethnography as a particular form of ethnography that recognizes ethnographic stories as agential through their capacity to work...... partners in a development aid project; it tells about the seemingly magic actions of a database used for monitoring. We use the note for discussing why we think it is important, in a situation where ethnographic stories are bought and sold as products, to name some of the ontological commitments that go...... into the crafting of these stories....

  8. Vaccination: problems and perspectives.

    Directory of Open Access Journals (Sweden)

    S. M. Kharit

    2009-01-01

    Full Text Available Massive vaccination had proved its effective morbidity reduction. Today it is necessary to extend vaccination schedule, creation of selective, regional schedules based on epidemiological, clinical, economical substantiation. Development of vaccination needs the profound scientific research, modernization of adverse reaction observing system, betterment training system and awareness of population.

  9. Oral vaccination of fish

    NARCIS (Netherlands)

    Embregts, Carmen W.E.; Forlenza, Maria

    2016-01-01

    The limited number of oral vaccines currently approved for use in humans and veterinary species clearly illustrates that development of efficacious and safe oral vaccines has been a challenge not only for fish immunologists. The insufficient efficacy of oral vaccines is partly due to antigen

  10. Meningococcal Vaccine (For Parents)

    Science.gov (United States)

    ... previous dose of meningococcal vaccine, to the DTaP vaccine , or to latex If your child has a history of Guillain-Barré syndrome (a disease of the nervous system that causes progressive weakness), talk to your doctor about whether the vaccines are a good idea. Caring for Your Child ...

  11. Hepatitis A Vaccine

    Science.gov (United States)

    Twinrix® (as a combination product containing Hepatitis A Vaccine, Hepatitis B Vaccine) ... Why get vaccinated against hepatitis A?Hepatitis A is a serious liver disease. It is caused by the hepatitis A virus (HAV). HAV is spread from ...

  12. Mary's Story: A Curriculum for Teaching Medical Terminology.

    Science.gov (United States)

    Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.

    This packet of materials for a class on medical terminology consists of a collection of stories with highlighted vocabulary, teacher's guide, and student's guide. The materials teach medical terms in a series of stories about a woman named Mary Consola. Each story begins with a list of word parts that will be learned; after the story, new word…

  13. Story immersion in a health videogame for childhood obesity prevention

    Science.gov (United States)

    Stories can serve as powerful tools for health interventions. Story immersion refers to the experience of being absorbed in a story. This is among the first studies to analyze story immersion’s role in health video games among children by addressing two main questions: Will children be more immersed...

  14. Sustainable vaccine development: a vaccine manufacturer's perspective.

    Science.gov (United States)

    Rappuoli, Rino; Hanon, Emmanuel

    2018-05-08

    Vaccination remains the most cost-effective public health intervention after clean water, and the benefits impressively outweigh the costs. The efforts needed to fulfill the steadily growing demands for next-generation and novel vaccines designed for emerging pathogens and new indications are only realizable in a sustainable business model. Vaccine development can be fast-tracked through strengthening international collaborations, and the continuous innovation of technologies to accelerate their design, development, and manufacturing. However, these processes should be supported by a balanced project portfolio, and by managing sustainable vaccine procurement strategies for different types of markets. Collectively this will allow a gradual shift to a more streamlined and profitable vaccine production, which can significantly contribute to the worldwide effort to shape global health. Copyright © 2018 GlaxoSmithKine Biologicals SA. Published by Elsevier Ltd.. All rights reserved.

  15. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... NEOMED) 26,193 views 5:39 Little Stars – Paediatric Palliative Care – Charlie's Story - Duration: 10:35. Little Stars 12,759 ... in to add this to Watch Later Add to Loading playlists...

  16. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... 21. KidsCancerChannel 64,265 views 5:21 Little Stars – Paediatric Palliative Care – Charlie's Story - Duration: 10:35. Little Stars 12,980 views 10:35 LIFE Before Death ...

  17. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology License Standard ...

  18. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... and Legacy through Pediatric Palliative Care - Duration: 5:39. Northeast Ohio Medical University (NEOMED) 26,045 views 5:39 Little Stars – Paediatric Palliative Care – Charlie's Story - Duration: ...

  19. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category ... Cancer: Palliative Care - Duration: 3:29. American Cancer Society 4,364 views 3:29 Perinatal Palliative Care - ...

  20. Stories, Action and Ethics in Management Education

    DEFF Research Database (Denmark)

    Jørgensen, Kenneth Mølbjerg

    2018-01-01

    This chapter discusses ethics in management education from Hannah Arendt’s notion of action. Action for Arendt is disclosed in storytelling and other artful expression whereby people make their appearance in the world as distinct human beings with passions, feelings, intentions, and voices. Stories...... are collective, situated, embodied, and material. It is through stories that people disclose themselves as subjects in interaction with other people. The chapter suggests that stories have ethical consequences in three areas. Firstly, they emphasize the creative act and the new beginning. “True” action distorts...... for the world and our worldly becoming. These three areas serve as important signposts for reworking management students’ stories. They have consequences for the design of teaching practices for heightening students’ moral awareness. These concern both management students’ work of the self on the self...

  1. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show less ...

  2. Pediatric Palliative Care: A Personal Story

    Science.gov (United States)

    ... a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show less ...

  3. Minimalism in the modern short story

    Directory of Open Access Journals (Sweden)

    A Razi

    2009-09-01

    Full Text Available Short story has recently become the focus of attention in the late decades in Iran. The expanding value of writing short story is actually a reasonable outcome of the dominance of minimalism- a movement which is based upon simplicity and shortness. Minimalist writers, leaving out redundant features of narration, mainly focus on essentialities through applying a variety of techniques such as cuttings from the interesting moments of real life, evading introduction, applying inter-referents, choice of words, short stanzas and sentences and so on. Looking upon critic’s opinion about such a tendency over the past and present, this article will come up with a brief explanation of the properties of such stories. Finally a sample story “candles will never go dead” will be analyzed and discussed in the lights of such techniques.

  4. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... The Keeney Family discuss pediatric palliative care - Duration: 12:07. Hospice of the Western Reserve 12,073 views 12:07 Perinatal Palliative Care - The Zimmer Family Story - ...

  5. Automated Story Capture From Internet Weblogs

    National Research Council Canada - National Science Library

    Gordon, Andrew S; Cao, Qun; Swanson, Reid

    2007-01-01

    .... first-person narratives about real-life experiences. Millions of these stories appear in Internet weblogs, offering a potentially valuable resource for future knowledge management and training applications...

  6. Genetic Testing: Understanding the Personal Stories.

    Science.gov (United States)

    DuBois, James M

    2015-01-01

    Twelve personal narratives address the challenges, benefits, and pitfalls of genetic testing. Three commentary articles explore these stories and suggest lessons that can be learned from them. The commentators come from backgrounds that include bioethics, public health, psychology, and philosophy.

  7. Researching transformative learning spaces through learners' stories

    DEFF Research Database (Denmark)

    Maslo, Elina

    spaces, learning to learn through languages, learners´ stories, qualitative research method Methodology or Methods/Research Instruments or Sources Used A number of semi structured qualitative interviews have been conducted with three learners of Danish as second language. The language learners...... in the paper is on the research process and methodological tools. The goal of this paper is to show, that learners´ stories have a huge potential in researching learning processes. References Benson, P. & D. Nunan (2004). Lerners´ stories. Difference and Diversity in Language Learning. Cambridge University...... to use learners´ stories as a research methodology in the field of learning in general and language learning in particular....

  8. Cultural Trauma and Life Stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene

    2007-01-01

    Aili Aarelaid-Tarti 15-aastase uuringu tulemused raamatus "Cultural Trauma and Life Stories", Hesinki, Kikimora Publications, 2006. Uuritud on kolme suurt rahvusgruppi 1940-test tingitud trauma kontekstis: eestlased kodumaal, eestlased eksiilis ja venekeelne rahvusgrupp Eestis postsovetlikus diskursuses

  9. Exploring Culture : Exercises, Stories and Synthetic Cultures

    NARCIS (Netherlands)

    Hofstede, G.J.

    2002-01-01

    A unique training book containing over 100 culture awareness exercises, dialogues, stories incidents and simulations that bring to life Geert Hofstede's five dimensions of culture. These dimensions are: power distance, collectivism versus individualism, femininity versus masculinity, uncertainly

  10. Enhancing children's health through digital story.

    Science.gov (United States)

    Wyatt, Tami H; Hauenstein, Emily

    2008-01-01

    Stories in all of their many forms, including books, plays, skits, movies, poems, and songs, appeal to individuals of all ages but especially the young. Children are easily engaged in stories, and today's generation of children, the millennium generation, demands interactive, multimedia-rich environments. Story as a teaching and learning technique is pervasive in the classroom but is infrequently used to promote health. Because of advancing technology, it is possible to create interactive digital storytelling programs that teach children health topics. Using digital storytelling in an interactive environment to promote health has not been tested, but there is empirical support for using story in health education and interactive technology to promote health. This article briefly reviews the literature and discusses how technology and storytelling can be joined to promote positive health outcomes.

  11. Passport to promiscuity or lifesaver: press coverage of HPV vaccination and risky sexual behavior.

    Science.gov (United States)

    Forster, Alice; Wardle, Jane; Stephenson, Judith; Waller, Jo

    2010-03-01

    A significant minority of parents are concerned about adolescents engaging in risky sexual behavior following human papillomavirus (HPV) vaccination. The way the HPV vaccine is reported in the media has the potential to influence public understanding and vaccination decisions. The present study examined the content of articles published between 2003 and 2008 in British national newspapers that addressed the issue of adolescents engaging in risky sexual behavior following HPV vaccination. We used mixed methods to analyze 92 articles in which the issue was mentioned. Qualitative framework analysis highlighted three main types of discussion: news stories proposing that adolescents will engage in risky sexual behavior following HPV vaccination, counterarguments insisting that adolescents will not engage in risky sexual behavior after HPV vaccination, and parents' views of the issue of risky sexual behavior. The results indicated that newspapers provide parents with broadly positive descriptive norms about vaccination; however, the issue that adolescents will engage in risky sexual behaviors following HPV vaccination is regularly discussed in the national press and has the potential to increase parents' concerns about vaccination.

  12. Peptide Vaccines for Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Rory C. F. De Brito

    2018-05-01

    Full Text Available Due to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits. Nevertheless, the use of whole parasite or their subunits for vaccine production has numerous disadvantages. Therefore, the use of Leishmania peptides to design more specific vaccines against leishmaniases seems promising. Moreover, peptides have several benefits in comparison with other kinds of antigens, for instance, good stability, absence of potentially damaging materials, antigen low complexity, and low-cost to scale up. By contrast, peptides are poor immunogenic alone, and they need to be delivered correctly. In this context, several approaches described in this review are useful to solve these drawbacks. Approaches, such as, peptides in combination with potent adjuvants, cellular vaccinations, adenovirus, polyepitopes, or DNA vaccines have been used to develop peptide-based vaccines. Recent advancements in peptide vaccine design, chimeric, or polypeptide vaccines and nanovaccines based on particles attached or formulated with antigenic components or peptides have been increasingly employed to drive a specific immune response. In this review, we briefly summarize the old, current, and future stands on peptide-based vaccines, describing the disadvantages and benefits associated with them. We also propose possible approaches to overcome the related weaknesses of synthetic vaccines and suggest future guidelines for their development.

  13. Peptide Vaccines for Leishmaniasis.

    Science.gov (United States)

    De Brito, Rory C F; Cardoso, Jamille M De O; Reis, Levi E S; Vieira, Joao F; Mathias, Fernando A S; Roatt, Bruno M; Aguiar-Soares, Rodrigo Dian D O; Ruiz, Jeronimo C; Resende, Daniela de M; Reis, Alexandre B

    2018-01-01

    Due to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits. Nevertheless, the use of whole parasite or their subunits for vaccine production has numerous disadvantages. Therefore, the use of Leishmania peptides to design more specific vaccines against leishmaniases seems promising. Moreover, peptides have several benefits in comparison with other kinds of antigens, for instance, good stability, absence of potentially damaging materials, antigen low complexity, and low-cost to scale up. By contrast, peptides are poor immunogenic alone, and they need to be delivered correctly. In this context, several approaches described in this review are useful to solve these drawbacks. Approaches, such as, peptides in combination with potent adjuvants, cellular vaccinations, adenovirus, polyepitopes, or DNA vaccines have been used to develop peptide-based vaccines. Recent advancements in peptide vaccine design, chimeric, or polypeptide vaccines and nanovaccines based on particles attached or formulated with antigenic components or peptides have been increasingly employed to drive a specific immune response. In this review, we briefly summarize the old, current, and future stands on peptide-based vaccines, describing the disadvantages and benefits associated with them. We also propose possible approaches to overcome the related weaknesses of synthetic vaccines and suggest future guidelines for their development.

  14. Intergenerational Lessons and 'Fabulous Stories'.

    Science.gov (United States)

    Lewenson, Sandra B; Welch, Cathryne A; Hassmiller, Susan B

    2015-10-01

    While directing the Future of Nursing: Campaign for Action, Susan B. Hassmiller, the Robert Wood Johnson Foundation's senior adviser for nursing, realized the value that nursing history could bring to the campaign. She decided to interview her mother, Jacqueline J. Wouwenberg, a 1947 graduate of the Bellevue Hospital School of Nursing, in order to better understand and contextualize changes that had occurred in the nursing profession during the 20th century. In collaboration with nurse historians Cathryne A. Welch and Sandra B. Lewenson, Hassmiller participated in interviewing her mother and was also interviewed herself. The stories that emerged revealed a great deal: each woman had found that nursing had given them countless opportunities that reflected the time periods in which they lived. Wouwenberg's experiences, transmitted to Hassmiller through words and actions, also served as important lessons for her daughter. This article shares five lessons: be independent and courageous, know that nursing has no bounds, follow your passion, honor diversity, and give back. It also asks readers to reflect on the relevance of nurses' work from one generation to the next..

  15. Top medical news stories 2015

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2015-12-01

    Full Text Available No abstract available. Article truncated after 150 words. Here is our list of the top seven medical news stories for 2015 with special emphasis on the Southwest. 7. Wearable health devices: A wave of wearable computing devices such as Fitbit and UP wristbands have people keeping track of how much they sit, stand, walk, climb stairs and calories they consume (1. These fitness-tracking devices herald a series of devices that will detect and monitor serious diseases. However, these so-called medical-grade wearables require approval from the U.S. Food and Drug Administration, a regulatory hurdle avoided by the fitness-tracking devices which will likely slow their introduction. 6. Caitlyn Jenner: Caitlyn Jenner became the most famous transgender woman in the world following an interview published in Vanity Fair (2. The Vanity Fair website saw 11.6 million visits curious about the former Olympic athlete. Though Jenner publicly shared her gender identity, many transgender Americans do not-12% of gender non-conforming adults said they ...

  16. Clients' and therapists' stories about psychotherapy.

    Science.gov (United States)

    Adler, Jonathan M

    2013-12-01

    This article provides an overview of the emerging field of research on clients' stories about their experiences in psychotherapy. The theory of narrative identity suggests that individuals construct stories about their lives in order to provide the self with a sense of purpose and unity. Psychotherapy stories serve both psychological functions. Focusing on the theme of agency as a vehicle for operationalizing purpose and coherence as a way of operationalizing unity, this article will describe the existing scholarship connecting psychotherapy stories to clients' psychological well-being. Results from cross-sectional qualitative and quantitative studies as well as longitudinal research indicate a connection between the stories clients tell about therapy and their psychological well-being, both over the course of treatment and after it is over. In addition, a preliminary analysis of therapists' stories about their clients' treatment is presented. These analyses reveal that the way therapists recount a particular client's therapy does not impact the relationships between clients' narratives and their improvement. The article concludes with a discussion of how this body of scholarship might be fruitfully applied in the realm of clinical practice. © 2012 Wiley Periodicals, Inc.

  17. The transformative power of story for healing.

    Science.gov (United States)

    Profeit-LeBlanc, Louise

    2003-01-01

    One of our goals in this session was, not just to talk about the healing power of narrative, but to experience it as well. Louise Profeit-LeBlanc is one of the presenters we invited specifically because of her skills as a storyteller. She has been heavily involved for several years as both an organizer and a participant in the Yukon Storytelling Festival, held every year in late May in Whitehorse. Woven into her presentation is a useful framework for differentiating various kinds of stories. As she tells us a series of stories, she takes us through a wide range of emotions from grief and loss to laughter and awe. For each of her stories, she gives us some personal contextual information that adds to the story’s meaning and helps us appreciate its significance. Her final story, in particular, is the kind of traditional story that has probably existed for a very long time. Such stories may be told with slightly different emphases, depending on the occasion, but they carry wisdom and value for every generation that hears them.

  18. Vaccines as Epidemic Insurance.

    Science.gov (United States)

    Pauly, Mark V

    2017-10-27

    This paper explores the relationship between the research for and development of vaccines against global pandemics and insurance. It shows that development in advance of pandemics of a portfolio of effective and government-approved vaccines does have some insurance properties: it requires incurring costs that are certain (the costs of discovering, developing, and testing vaccines) in return for protection against large losses (if a pandemic treatable with one of the vaccines occurs) but also with the possibility of no benefit (from a vaccine against a disease that never reaches the pandemic stage). It then argues that insurance against the latter event might usefully be offered to organizations developing vaccines, and explores the benefits of insurance payments to or on behalf of countries who suffer from unpredictable pandemics. These ideas are then related to recent government, industry, and philanthropic efforts to develop better policies to make vaccines against pandemics available on a timely basis.

  19. Vaccines as Epidemic Insurance

    Directory of Open Access Journals (Sweden)

    Mark V. Pauly

    2017-10-01

    Full Text Available This paper explores the relationship between the research for and development of vaccines against global pandemics and insurance. It shows that development in advance of pandemics of a portfolio of effective and government-approved vaccines does have some insurance properties: it requires incurring costs that are certain (the costs of discovering, developing, and testing vaccines in return for protection against large losses (if a pandemic treatable with one of the vaccines occurs but also with the possibility of no benefit (from a vaccine against a disease that never reaches the pandemic stage. It then argues that insurance against the latter event might usefully be offered to organizations developing vaccines, and explores the benefits of insurance payments to or on behalf of countries who suffer from unpredictable pandemics. These ideas are then related to recent government, industry, and philanthropic efforts to develop better policies to make vaccines against pandemics available on a timely basis.

  20. 42 CFR 410.57 - Pneumococcal vaccine and flu vaccine.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Pneumococcal vaccine and flu vaccine. 410.57 Section 410.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... § 410.57 Pneumococcal vaccine and flu vaccine. (a) Medicare Part B pays for pneumococcal vaccine and its...

  1. vaccination with newcastle disease vaccines strain i2 and lasota

    African Journals Online (AJOL)

    UP Employee

    mash feed as vaccine carriers was conducted. Newcastle disease vaccine strain I2 and. NDV La Sota vaccines provided protection to commercial and local chickens vaccinated through i/o, i/m or dw. No significant difference (P≤0.05) was observed in the antibody titre of commercial or local chickens vaccinated with either ...

  2. From Stories of Staying to Stories of Leaving: A US Beginning Teacher's Experience

    Science.gov (United States)

    Craig, Cheryl J.

    2014-01-01

    This narrative inquiry traces a beginning teacher's unfolding career over a six-year period in a diverse middle school in the fourth largest city in the USA. The work revolves around two conceptualizations: "stories to live by" and "stories to leave by." How these identity-related phenomena surface and play out in an…

  3. Using Counter-Stories to Challenge Stock Stories about Traveller Families

    Science.gov (United States)

    D'Arcy, Kate

    2017-01-01

    Critical Race Theory (CRT) is formed from a series of different methodological tools to expose and address racism and discrimination. Counter-stories are one of these tools. This article considers the potential of counter-stories as a methodological, theoretical and practical tool to analyse existing educational inequalities for Traveller…

  4. Exploring Cultures and Their Stories: Stories from Uganda, Bolivia, Sri Lanka, Korea, Bulgaria, Germany, and Macedonia.

    Science.gov (United States)

    Joy, Flora

    Intended for teachers of middle and secondary schools, this book presents folk-stories to provide readers (listeners) with insight into other cultures. The book is organized into eight sections, each featuring a country or a people. Each section has a divider page (which gives the story title, the country or region of the culture, and a map), a…

  5. Story Map: un nuovo modo di raccontare storie con le mappe

    Directory of Open Access Journals (Sweden)

    Esri Italia

    2014-02-01

    Full Text Available The article concern the latest web applications developed by ESRI calls Story Map. These represent a new way of telling stories and are simple to implement, intuitive, open source and have a varied series of application among which the most important are Map Tour, Storytelling text and legend, , Short list and Swipe.

  6. Current Ebola vaccines

    Science.gov (United States)

    Hoenen, Thomas; Groseth, Allison; Feldmann, Heinz

    2012-01-01

    Introduction Ebolaviruses cause severe viral hemorrhagic fever in humans and non-human primates, with case fatality rates of up to 90%. Currently, neither a specific treatment nor a vaccine licensed for use in humans is available. However, a number of vaccine candidates have been developed in the last decade that are highly protective in non-human primates, the gold standard animal model for Ebola hemorrhagic fever. Areas covered This review analyzes a number of scenarios for the use of ebolavirus vaccines, discusses the requirements for ebolavirus vaccines in these scenarios, and describes current ebolavirus vaccines. Among these vaccines are recombinant Adenoviruses, recombinant Vesicular Stomatitis viruses, recombinant Human Parainfluenza viruses and virus-like particles. Interestingly, one of these vaccine platforms, based on recombinant Vesicular Stomatitis viruses, has also demonstrated post-exposure protection in non-human primates. Expert opinion The most pressing remaining challenge is now to move these vaccine candidates forward into human trials and towards licensure. In order to achieve this, it will be necessary to establish the mechanisms and correlates of protection for these vaccines, and to continue to demonstrate their safety, particularly in potentially immunocompromised populations. However, already now there is sufficient evidence that, from a scientific perspective, a vaccine protective against ebolaviruses is possible. PMID:22559078

  7. Vaccines in a hurry.

    Science.gov (United States)

    Søborg, Christian; Mølbak, Kåre; Doherty, T Mark; Ulleryd, Peter; Brooks, Tim; Coenen, Claudine; van der Zeijst, Ben

    2009-05-26

    Preparing populations for health threats, including threats from new or re-emerging infectious diseases is recognised as an important public health priority. The development, production and application of emergency vaccinations are the important measures against such threats. Vaccines are cost-effective tools to prevent disease, and emergency vaccines may be the only means to prevent a true disaster for global society in the event of a new pandemic with potential to cause morbidity and mortality comparable to the Spanish flu, the polio epidemics in the 1950s, or the SARS outbreak in 2003 if its spread had not been contained in time. Given the early recognition of a new threat, and given the advances of biotechnology, vaccinology and information systems, it is not an unrealistic goal to have promising prototype vaccine candidates available in a short time span following the identification of a new infectious agent; this is based on the assumption that the emerging infection is followed by natural immunity. However, major bottlenecks for the deployment of emergency vaccine are lack of established systems for fast-track regulatory approval of such candidates and limited international vaccine production capacity. In the present discussion paper, we propose mechanisms to facilitate development of emergency vaccines in Europe by focusing on public-private scientific partnerships, fast-track approval of emergency vaccine by regulatory agencies and proposing incentives for emergency vaccine production in private vaccine companies.

  8. Vaccine strategies: Optimising outcomes.

    Science.gov (United States)

    Hardt, Karin; Bonanni, Paolo; King, Susan; Santos, Jose Ignacio; El-Hodhod, Mostafa; Zimet, Gregory D; Preiss, Scott

    2016-12-20

    Successful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine. Reliable immunisation service funding is another important factor and low income countries often need external supplementary sources of finance. Many regions also obtain support in generating an evidence base for vaccination via initiatives created by organisations including World Health Organization (WHO), the Pan American Health Organization (PAHO), the Agence de Médecine Préventive and the Sabin Vaccine Institute. Strong monitoring and surveillance mechanisms are also required. An example is the efficient and low-cost approaches for measuring the impact of the hepatitis B control initiative and evaluating achievement of goals that have been established in the WHO Western Pacific region. A review of implementation strategies reveals differing degrees of success. For example, in the Americas, PAHO advanced a measles-mumps-rubella vaccine strategy, targeting different population groups in mass, catch-up and follow-up vaccination campaigns. This has had much success but coverage data from some parts of the region suggest that children are still not receiving all appropriate vaccines, highlighting problems with local service infrastructures. Stark differences in coverage levels are also observed among high income countries, as is the case with HPV vaccine implementation in the USA versus the UK and Australia, reflecting differences in delivery settings. Experience and research have shown which vaccine strategies work well and the

  9. The Meningitis Vaccine Project.

    Science.gov (United States)

    LaForce, F Marc; Konde, Kader; Viviani, Simonetta; Préziosi, Marie-Pierre

    2007-09-03

    Epidemic meningococcal meningitis is an important public health problem in sub-Saharan Africa. Current control measures rely on reactive immunizations with polysaccharide (PS) vaccines that do not induce herd immunity and are of limited effectiveness in those under 2 years of age. Conversely, polysaccharide conjugate vaccines are effective in infants and have consistently shown an important effect on decreasing carriage, two characteristics that facilitate disease control. In 2001 the Meningitis Vaccine Project (MVP) was created as a partnership between PATH and the World Health Organization (WHO) with the goal of eliminating meningococcal epidemics in Africa through the development, licensure, introduction, and widespread use of conjugate meningococcal vaccines. Since group A Neisseria meningitidis (N. meningitidis) is the dominant pathogen causing epidemic meningitis in Africa MVP is developing an affordable (US$ 0.40 per dose) meningococcal A (Men A) conjugate vaccine through an innovative international partnership that saw transfer of a conjugation and fermentation technology to a developing country vaccine manufacturer. A Phase 1 study of the vaccine in India has shown that the product is safe and immunogenic. Phase 2 studies have begun in Africa, and a large demonstration study of the conjugate vaccine is envisioned for 2008-2009. After extensive consultations with African public health officials a vaccine introduction plan has been developed that includes introduction of the Men A conjugate vaccine into standard Expanded Programme on Immunization (EPI) schedules but also emphasizes mass vaccination of 1-29 years old to induce herd immunity, a strategy that has been shown to be highly effective when the meningococcal C (Men C) conjugate vaccine was introduced in several European countries. The MVP model is a clear example of the usefulness of a "push mechanism" to finance the development of a needed vaccine for the developing world.

  10. 75 FR 48706 - Proposed Vaccine Information Materials for Rotavirus Vaccine

    Science.gov (United States)

    2010-08-11

    ... Vaccine Information Materials for Rotavirus Vaccine AGENCY: Centers for Disease Control and Prevention... information materials for rotavirus vaccine. DATES: Written comments are invited and must be received on or... (chickenpox), pneumococcal conjugate, rotavirus, hepatitis A, meningococcal, human papillomavirus (HPV), and...

  11. 'It's just so much waste.' A qualitative investigation of food waste in a universal free School Breakfast Program.

    Science.gov (United States)

    Blondin, Stacy A; Djang, Holly Carmichael; Metayer, Nesly; Anzman-Frasca, Stephanie; Economos, Christina D

    2015-06-01

    To understand stakeholders' perspectives on food waste in a universal free School Breakfast Program implementing a Breakfast in the Classroom model. Semi-structured focus groups and interviews were conducted with school district stakeholders. Inductive methods were used to code resulting transcripts, from which themes were identified. The analysis provides a thematic analysis of stakeholders' perspectives on food waste in the School Breakfast Program. Ten elementary schools in a large urban school district implementing a universal free Breakfast in the Classroom model of the US national School Breakfast Program. Elementary-school students (n 85), parents (n 86), teachers (n 44), cafeteria managers (n 10) and school principals (n 10). Stakeholders perceived food waste as a problem and expressed concern regarding the amount of food wasted. Explanations reported for food waste included food-related (palatability and accessibility), child-related (taste preferences and satiation) and programme-related (duration, food service policies, and coordination) factors. Milk and fruit were perceived as foods particularly susceptible to waste. Several food waste mitigation strategies were identified by participants: saving food for later, actively encouraging children's consumption, assisting children with foods during mealtime, increasing staff support, serving smaller portion sizes, and composting and donating uneaten food. Stakeholders recognized food waste as a problem, reported myriad contributing factors, and have considered and employed multiple and diverse mitigation strategies. Changes to the menu and/or implementation logistics, as well as efforts to use leftover food productively, may be possible strategies of reducing waste and improving the School Breakfast Program's economic, environmental and nutritional impact.

  12. Vaccine process technology.

    Science.gov (United States)

    Josefsberg, Jessica O; Buckland, Barry

    2012-06-01

    The evolution of vaccines (e.g., live attenuated, recombinant) and vaccine production methods (e.g., in ovo, cell culture) are intimately tied to each other. As vaccine technology has advanced, the methods to produce the vaccine have advanced and new vaccine opportunities have been created. These technologies will continue to evolve as we strive for safer and more immunogenic vaccines and as our understanding of biology improves. The evolution of vaccine process technology has occurred in parallel to the remarkable growth in the development of therapeutic proteins as products; therefore, recent vaccine innovations can leverage the progress made in the broader biotechnology industry. Numerous important legacy vaccines are still in use today despite their traditional manufacturing processes, with further development focusing on improving stability (e.g., novel excipients) and updating formulation (e.g., combination vaccines) and delivery methods (e.g., skin patches). Modern vaccine development is currently exploiting a wide array of novel technologies to create safer and more efficacious vaccines including: viral vectors produced in animal cells, virus-like particles produced in yeast or insect cells, polysaccharide conjugation to carrier proteins, DNA plasmids produced in E. coli, and therapeutic cancer vaccines created by in vitro activation of patient leukocytes. Purification advances (e.g., membrane adsorption, precipitation) are increasing efficiency, while innovative analytical methods (e.g., microsphere-based multiplex assays, RNA microarrays) are improving process understanding. Novel adjuvants such as monophosphoryl lipid A, which acts on antigen presenting cell toll-like receptors, are expanding the previously conservative list of widely accepted vaccine adjuvants. As in other areas of biotechnology, process characterization by sophisticated analysis is critical not only to improve yields, but also to determine the final product quality. From a regulatory

  13. Vaccination against seasonal flu

    CERN Multimedia

    2015-01-01

    The Medical Service once again recommends you to get your annual flu vaccination for the year.   Vaccination is the most effective way of avoiding the illness and any serious consequences and protecting those around you. The flu can have especially serious consequences for people with chronic conditions (diabetes, cardio-vascular disease, etc.), pregnant women, infants, and people over 65 years of age. Remember, anyone working on the CERN site who wishes to be vaccinated against seasonal flu should go to the Infirmary (Building 57, ground floor) with their vaccine. The Medical Service will issue a prescription on the day of the vaccination for the purposes of reimbursement by UNIQA. NB: The Medical Service cannot provide this vaccination service for family members or retired members of the personnel. For more information: • The "Seasonal flu" flyer by the Medical Service • Recommendations of the Swiss Federal Office of Public...

  14. Prophylactic Hepatitis E Vaccine.

    Science.gov (United States)

    Zhang, Jun; Zhao, Qinjian; Xia, Ningshao

    2016-01-01

    Hepatitis E has been increasingly recognized as an underestimated global disease burden in recent years. Subpopulations with more serious infection-associated damage or death include pregnant women, patients with basic liver diseases, and elderly persons. Vaccine would be the most effective means for prevention of HEV infection. The lack of an efficient cell culture system for HEV makes the development of classic inactive or attenuated vaccine infeasible. Hence, the recombinant vaccine approaches are explored deeply. The neutralizing sites are located almost exclusively in the capsid protein, pORF2, of the virion. Based on pORF2, many vaccine candidates showed potential of protecting primate animals; two of them were tested in human and evidenced to be well tolerated in adults and highly efficacious in preventing hepatitis E. The world's first hepatitis E vaccine, Hecolin ® (HEV 239 vaccine), was licensed in China and launched in 2012.

  15. Vaccination and neurological disorders

    Directory of Open Access Journals (Sweden)

    Anastasia Gkampeta

    2015-12-01

    Full Text Available Active immunization of children has been proven very effective in elimination of life threatening complications of many infectious diseases in developed countries. However, as vaccination-preventable infectious diseases and their complications have become rare, the interest focuses on immunization-related adverse reactions. Unfortunately, fear of vaccination-related adverse effects can led to decreased vaccination coverage and subsequent epidemics of infectious diseases. This review includes reports about possible side effects following vaccinations in children with neurological disorders and also published recommendations about vaccinating children with neurological disorders. From all international published data anyone can conclude that vaccines are safer than ever before, but the challenge remains to convey this message to society.

  16. Vaccines and Kawasaki disease.

    Science.gov (United States)

    Esposito, Susanna; Bianchini, Sonia; Dellepiane, Rosa Maria; Principi, Nicola

    2016-01-01

    The distinctive immune system characteristics of children with Kawasaki disease (KD) could suggest that they respond in a particular way to all antigenic stimulations, including those due to vaccines. Moreover, treatment of KD is mainly based on immunomodulatory therapy. These factors suggest that vaccines and KD may interact in several ways. These interactions could be of clinical relevance because KD is a disease of younger children who receive most of the vaccines recommended for infectious disease prevention. This paper shows that available evidence does not support an association between KD development and vaccine administration. Moreover, it highlights that administration of routine vaccines is mandatory even in children with KD and all efforts must be made to ensure the highest degree of protection against vaccine-preventable diseases for these patients. However, studies are needed to clarify currently unsolved issues, especially issues related to immunologic interference induced by intravenous immunoglobulin and biological drugs.

  17. Vaccine development for syphilis.

    Science.gov (United States)

    Lithgow, Karen V; Cameron, Caroline E

    2017-01-01

    Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a globally prevalent disease despite remaining susceptible to penicillin treatment. Syphilis vaccine development is a viable preventative approach that will serve to complement public health-oriented syphilis prevention, screening and treatment initiatives to deliver a two-pronged approach to stemming disease spread worldwide. Areas covered: This article provides an overview of the need for development of a syphilis vaccine, summarizes significant information that has been garnered from prior syphilis vaccine studies, discusses the critical aspects of infection that would have to be targeted by a syphilis vaccine, and presents the current understanding within the field of the correlates of protection needed to be achieved through vaccination. Expert commentary: Syphilis vaccine development should be considered a priority by industry, regulatory and funding agencies, and should be appropriately promoted and supported.

  18. The Latest in Vaccine Policies: Selected Issues in School Vaccinations, Healthcare Worker Vaccinations, and Pharmacist Vaccination Authority Laws.

    Science.gov (United States)

    Barraza, Leila; Schmit, Cason; Hoss, Aila

    2017-03-01

    This paper discusses recent changes to state legal frameworks for mandatory vaccination in the context of school and healthcare worker vaccination. It then discusses state laws that allow pharmacists the authority to vaccinate.

  19. Needle-free influenza vaccination

    NARCIS (Netherlands)

    Amorij, Jean-Pierre; Hinrichs, Wouter L.J.; Frijlink, Henderik W.; Wilschut, Jan C.; Huckriede, Anke

    2010-01-01

    Vaccination is the cornerstone of influenza control in epidemic and pandemic situations. Influenza vaccines are typically given by intramuscular injection. However, needle-free vaccinations could offer several distinct advantages over intramuscular injections: they are pain-free, easier to

  20. What Vaccines Do You Need?

    Science.gov (United States)

    ... Recommendations Why Immunize? Vaccines: The Basics The Adult Vaccine Quiz Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir Vaccines are recommended for adults based on age, health ...

  1. Recommended Vaccines for Healthcare Workers

    Science.gov (United States)

    ... Vaccination Resources for Healthcare Professionals Recommended Vaccines for Healthcare Workers Recommend on Facebook Tweet Share Compartir On ... for More Information Resources for Those Vaccinating HCWs Healthcare workers (HCWs) are at risk for exposure to ...

  2. Holistic nurses' stories of personal healing.

    Science.gov (United States)

    Smith, Marlaine C; Zahourek, Rothlyn; Hines, Mary Enzman; Engebretson, Joan; Wardell, Diane Wind

    2013-09-01

    The purpose of this study was to uncover the nature, experiences, and meaning of personal healing for holistic nurses through their narrative accounts. The study employed a qualitative descriptive design with methods of narrative and story inquiry. Participants were nurse attendees at an American Holistic Nurses' Association conference who volunteered for the study. They were invited to share a story about healing self or another. Twenty-five stories were collected; seven were about personal healing, and these are the focus of this analysis. Data were analyzed using a hybrid approach from narrative and story inquiry methods. Eleven themes were clustered under three story segments. The themes within the Call to the Healing Encounter are the following: recognition of the need to resolve a personal or health crisis, knowledge of or engagement in self-care practices, and reliance on intuitive knowing. Themes under the Experience of Healing are the following: connections; profound sensations, perceptions, and events; awareness of the reciprocal nature of healing; inner resolution: forgiveness, awakening, and acceptance; use of multiple holistic approaches; and witnessing manifestations of healing. The themes for Insights are the following: gratitude and appreciation and ongoing journey. A metastory synthesizing the themes is presented, and findings are related to existing literature on healing.

  3. Rotavirus vaccines and vaccination in Latin America

    Directory of Open Access Journals (Sweden)

    Linhares Alexandre C.

    2000-01-01

    Full Text Available Worldwide, rotaviruses account for more than 125 million cases of infantile gastroenteritis and nearly 1 million deaths per year, mainly in developing countries. Rather than other control measures, vaccination is most likely to have a major impact on rotavirus disease incidence. The peak incidence of rotavirus diarrhea occurs between 6 and 24 months of age. In developing countries, however, cases are not uncommon among children younger than 6 months. G serotypes 1 to 4 are responsible for most disease, but there are indications that in Brazil that G type 5 is of emerging epidemiological importance. Both homotypic and heterotypic responses are elicited during natural rotavirus infection, and the immunological response at the intestinal mucosal surface is probably the more consistent predictor of clinical immunity. With the primary objective of protecting children against life-threatening dehydrating diarrhea, many approaches to rotavirus vaccine development have been attempted. One vaccine, the tetravalent rhesus-human reassortant rotavirus vaccine (RRV-TV, was given licensing approval in the United States of America, introduced to the market, and later withdrawn. A number of studies have found better efficacy of RRV-TV in developed countries than in developing ones. Field trials with a 4 X 10(4 plaque-forming units (PFU preparation of RRV-TV have been carried out in two countries in Latin America, Brazil and Peru. Those trials yielded protective efficacy rates against all rotavirus diarrhea ranging from 18% to 35%. Data from a large catchment trial in Venezuela with a higher RRV-TV dose, of 4 X 10(5 PFU/dose, indicated an efficacy rate of 48% against all rotavirus diarrhea and 88% against severe rotavirus diarrhea. It appears that breast-feeding does not compromise the efficacy of RRV-TV if three doses of the vaccine are administered. Similarly, possible interference of oral poliovirus vaccine with the "take" of the rotavirus vaccine can be

  4. Rotavirus vaccines and vaccination in Latin America

    Directory of Open Access Journals (Sweden)

    Alexandre C. Linhares

    2000-11-01

    Full Text Available Worldwide, rotaviruses account for more than 125 million cases of infantile gastroenteritis and nearly 1 million deaths per year, mainly in developing countries. Rather than other control measures, vaccination is most likely to have a major impact on rotavirus disease incidence. The peak incidence of rotavirus diarrhea occurs between 6 and 24 months of age. In developing countries, however, cases are not uncommon among children younger than 6 months. G serotypes 1 to 4 are responsible for most disease, but there are indications that in Brazil that G type 5 is of emerging epidemiological importance. Both homotypic and heterotypic responses are elicited during natural rotavirus infection, and the immunological response at the intestinal mucosal surface is probably the more consistent predictor of clinical immunity. With the primary objective of protecting children against life-threatening dehydrating diarrhea, many approaches to rotavirus vaccine development have been attempted. One vaccine, the tetravalent rhesus-human reassortant rotavirus vaccine (RRV-TV, was given licensing approval in the United States of America, introduced to the market, and later withdrawn. A number of studies have found better efficacy of RRV-TV in developed countries than in developing ones. Field trials with a 4 X 10(4 plaque-forming units (PFU preparation of RRV-TV have been carried out in two countries in Latin America, Brazil and Peru. Those trials yielded protective efficacy rates against all rotavirus diarrhea ranging from 18% to 35%. Data from a large catchment trial in Venezuela with a higher RRV-TV dose, of 4 X 10(5 PFU/dose, indicated an efficacy rate of 48% against all rotavirus diarrhea and 88% against severe rotavirus diarrhea. It appears that breast-feeding does not compromise the efficacy of RRV-TV if three doses of the vaccine are administered. Similarly, possible interference of oral poliovirus vaccine with the "take" of the rotavirus vaccine can be

  5. Pricing of new vaccines

    OpenAIRE

    Lee, Bruce Y; McGlone, Sarah M

    2010-01-01

    New vaccine pricing is a complicated process that could have substantial long-standing scientific, medical and public health ramifications. Pricing can have a considerable impact on new vaccine adoption and, thereby, either culminate or thwart years of research and development and public health efforts. Typically, pricing strategy consists of the following eleven components: (1) Conduct a target population analysis; (2) Map potential competitors and alternatives; (3) Construct a vaccine targe...

  6. Underutilization of Influenza Vaccine

    Directory of Open Access Journals (Sweden)

    Marshall K. Cheney

    2013-04-01

    Full Text Available Yearly influenza vaccination continues to be underutilized by those who would most benefit from it. The Health Belief Model was used to explain differences in beliefs about influenza vaccination among at-risk individuals resistant to influenza vaccination. Survey data were collected from 74 members of at-risk groups who were not vaccinated for influenza during the previous flu season. Accepting individuals were more likely to perceive flu as a threat to health and perceive access barriers, and cues to action were the most important influence on whether they plan to get vaccinated. In comparison, resistant individuals did not feel threatened by the flu, access barriers were not a problem, and they did not respond favorably to cues to action. Perceived threat, perceived access barriers, and cues to action were significantly associated with plans to be vaccinated for influenza in the next flu season. Participants who saw influenza as a threat to their health had 5.4 times the odds of planning to be vaccinated than those who did not. Participants reporting barriers to accessing influenza vaccination had 7.5 times the odds of reporting plans to be vaccinated. Those responding positively to cues to action had 12.2 times the odds of planning to be vaccinated in the next flu season than those who did not. Accepting and resistant individuals have significant differences in their beliefs, which require different intervention strategies to increase vaccination rates. These findings provide important information to researchers and practitioners working to increase influenza vaccination rates.

  7. Respiratory Syncytial Virus Vaccines

    OpenAIRE

    Dudas, Robert A.; Karron, Ruth A.

    1998-01-01

    Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract illness (LRI) in infants and children worldwide and causes significant LRI in the elderly and in immunocompromised patients. The goal of RSV vaccination is to prevent serious RSV-associated LRI. There are several obstacles to the development of successful RSV vaccines, including the need to immunize very young infants, who may respond inadequately to vaccination; the existence of two antigenically d...

  8. Vaccines, our shared responsibility.

    Science.gov (United States)

    Pagliusi, Sonia; Jain, Rishabh; Suri, Rajinder Kumar

    2015-05-05

    The Developing Countries Vaccine Manufacturers' Network (DCVMN) held its fifteenth annual meeting from October 27-29, 2014, New Delhi, India. The DCVMN, together with the co-organizing institution Panacea Biotec, welcomed over 240 delegates representing high-profile governmental and nongovernmental global health organizations from 36 countries. Over the three-day meeting, attendees exchanged information about their efforts to achieve their shared goal of preventing death and disability from known and emerging infectious diseases. Special praise was extended to all stakeholders involved in the success of polio eradication in South East Asia and highlighted challenges in vaccine supply for measles-rubella immunization over the coming decades. Innovative vaccines and vaccine delivery technologies indicated creative solutions for achieving global immunization goals. Discussions were focused on three major themes including regulatory challenges for developing countries that may be overcome with better communication; global collaborations and partnerships for leveraging investments and enable uninterrupted supply of affordable and suitable vaccines; and leading innovation in vaccines difficult to develop, such as dengue, Chikungunya, typhoid-conjugated and EV71, and needle-free technologies that may speed up vaccine delivery. Moving further into the Decade of Vaccines, participants renewed their commitment to shared responsibility toward a world free of vaccine-preventable diseases. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  9. Vaccines: Shaping global health.

    Science.gov (United States)

    Pagliusi, Sonia; Ting, Ching-Chia; Lobos, Fernando

    2017-03-14

    The Developing Countries Vaccine Manufacturers' Network (DCVMN) gathered leaders in immunization programs, vaccine manufacturing, representatives of the Argentinean Health Authorities and Pan American Health Organization, among other global health stakeholders, for its 17th Annual General Meeting in Buenos Aires, to reflect on how vaccines are shaping global health. Polio eradication and elimination of measles and rubella from the Americas is a result of successful collaboration, made possible by timely supply of affordable vaccines. After decades of intense competition for high-value markets, collaboration with developing countries has become critical, and involvement of multiple manufacturers as well as public- and private-sector investments are essential, for developing new vaccines against emerging infectious diseases. The recent Zika virus outbreak and the accelerated Ebola vaccine development exemplify the need for international partnerships to combat infectious diseases. A new player, Coalition for Epidemic Preparedness Innovations (CEPI) has made its entrance in the global health community, aiming to stimulate research preparedness against emerging infections. Face-to-face panel discussions facilitated the dialogue around challenges, such as risks of viability to vaccine development and regulatory convergence, to improve access to sustainable vaccine supply. It was discussed that joint efforts to optimizing regulatory pathways in developing countries, reducing registration time by up to 50%, are required. Outbreaks of emerging infections and the global Polio eradication and containment challenges are reminders of the importance of vaccines' access, and of the importance of new public-private partnerships. Copyright © 2017.

  10. Tetanus, Diphtheria, Pertussis (Tdap) Vaccine

    Science.gov (United States)

    Adacel® (as a combination product containing Diphtheria, Tetanus Toxoids, Acellular Pertussis Vaccine) ... Boostrix® (as a combination product containing Diphtheria, Tetanus Toxoids, Acellular Pertussis Vaccine)

  11. Transnationalism as a motif in family stories.

    Science.gov (United States)

    Stone, Elizabeth; Gomez, Erica; Hotzoglou, Despina; Lipnitsky, Jane Y

    2005-12-01

    Family stories have long been recognized as a vehicle for assessing components of a family's emotional and social life, including the degree to which an immigrant family has been willing to assimilate. Transnationalism, defined as living in one or more cultures and maintaining connections to both, is now increasingly common. A qualitative study of family stories in the family of those who appear completely "American" suggests that an affiliation with one's home country is nevertheless detectable in the stories via motifs such as (1) positively connotated home remedies, (2) continuing denigration of home country "enemies," (3) extensive knowledge of the home country history and politics, (4) praise of endogamy and negative assessment of exogamy, (5) superiority of home country to America, and (6) beauty of home country. Furthermore, an awareness of which model--assimilationist or transnational--governs a family's experience may help clarify a clinician's understanding of a family's strengths, vulnerabilities, and mode of framing their cultural experiences.

  12. SHORT STORIES IN THE BALKANS AND CONTEMPORARYSHORT STORIES IN THE WORLD

    Directory of Open Access Journals (Sweden)

    Larisa Softic - Gasal

    2014-01-01

    Full Text Available A comparative analysis of selected short stories in the Balkan countries, as well as contemporary short stories of the world, will show us that the key themes of those stories are very similar to the short stories written during the period of transition in Bosnia and Herzegovina (1995-2010. For example, the story of the Soul Operation by an Iranian writer Mohsen Mahmalbafa, The Falcons by a Dutch writer Kader Abdolaha and On the Kitchen Stairs by a Polish writer Witold Gombrowic zinter connect with short stories by authors from Bosnia and Herzegovina, such as The Secret of Raspberry jam by Karim Zaimović or The Devilish work of Zoran Riđanović. A common thread manifests itself in the aforementioned stories, more specifically, a common theme which focuses on the need for eradication of the seeds of submission and compliance with the political system. Most authors focus on their domestic political systems; however, some portray and analyze systems in other countries as they see it, such as a Dutch narrator who focuses on a potential threat of infringement of human freedom. Moreover, Bellow Hubei by an Argentinian writer Anhelika Gorodis her underlines the importance of humanization within a political order. Faruk Šehić examines the political system in Bosnia and Herzegovina from a slightly different perspective. His collection of stories Under Pressure emphases the issue of pressure in the above war model of short stories in Bosnia and Herzegovina. These stories are the product of pressure and anxiety, with intent to latently promote new ways of spiritual survival, directly relating to the concept and the theme of the story The Past Age Man by Christian Karlson Stead. Further analysis of the alienation theme singled out short stories in Bosnia and Herzegovina, Plants are Something Else by Alma Lazarevska and Dialogues by Lamija Begagić, and pointed out their connection with some recent international short stories such as The Last Defence by

  13. Stories and story telling in first-levellanguage learning: a re-evaluation

    Directory of Open Access Journals (Sweden)

    Robert W. Blair

    2013-02-01

    Full Text Available This paper proposes that in the midst of all our theories on language teaching and language learning, we might have overlooked an age-old tool that has always been at the disposal of mankind; the telling of stories. Attention is drawn to how some have found in stories and story telling a driving force of natural language acquisition, a key that can unlock the intuitive faculties ofthe mind. A case is being made out for the re-instalment of stories and associated activities as a means of real, heart-felt functional communication in a foreign language, rather than through a direct assault on the structure of the language itself. Met hierdie artikel word daar voorgestel dat daar opnuut gekyk moet word na 'n hulpmiddel wat so oud is as die mensheid self en wat nog altyd tot ons beskikking was, naamlik stories en die vertel daarvan. Die aandag word daarop gevestig dat daar persone is wat in stories en die verbale oordrag daarvan 'n stukrag ontdek het tot natuurlike taalvaardigheid, 'n sleutel tot die intultiewe breinfunksies. Daar word 'n saak uitgemaak vir die terugkeer na stories en gepaardgaande aktiwiteite as middel tot 'n egte, diep deurleefde en funksionele wyse van kommunikasie in 'n vreemde taal, eerder as 'n direkte aanslag op die taalstruktuur self.

  14. Gypsy stories: Narrative as a teaching stratagem

    Directory of Open Access Journals (Sweden)

    Čvorović Jelena

    2010-01-01

    Full Text Available This paper discusses the performance of narratives as adaptive cultural beha­viors among Gypsies in Mačva county, western Serbia. Storytelling is a universal activity and may well be oldest of the arts. It has always provided a vehicle for the expression of ideas, particularly in societies relying on oral tradition. Gypsies are present in Serbia since the Middle Ages, living within a larger Serbian culture as a minority group. Mačva, an agriculturally rich county in western Serbia, is a place where local Gypsy traditions are still alive and which help distinguish between Gypsy subgroups and the larger Serbian society. The stories analyzed are part of a collec­tion made from several different Gypsy groups exhibiting varying degrees of influence from Serbian culture. Gypsies in Serbia have no written literature, but possess a rich and varied storytelling tradition delivered by word of mouth through the generations. Their stories bear testimony to the evolutionarily important mecha­nisms employed by Gypsies to make their way in the world. Gypsy stories concern many aspects of the relationship between themselves and other social groups, both in the past and the present. At the same time, the stories deal with universal adaptive problems, such as origin/ethnicity, kinship and mate acquisition. By applying the concepts and folk knowledge from their own culture, Gypsies have managed to provide for themselves the guidelines to overcome these problems within a par­ticular environment. Thus it is that these stories reflect both human universals and cultural peculiarities - by utilization of localized cultural solutions to adaptive problems. The success Gypsies have achieved in surviving harassment, and their ability to sustain themselves and their cultures despite social rejection can be attributed, in part, to the power of the traditional stories to influence the behavior of those who hear them. For the Gypsies, telling and listening to the stories

  15. Active listening to cancer patients' stories.

    Science.gov (United States)

    ten Kroode, H F

    1998-08-01

    Approximately two thirds of all Dutch cancer patients have severe emotional problems; shortly after their change from the treatment regime into the regime of medical controls. Half of them even need professional support. It is, therefore, important that a professional listens with empathy to the patient's version of the illness story. Story telling helps to overcome the existential crisis of being a cancer patient; it is an essential step in the revalidation process. Themes and open questions which structure the communication are suggested in this article.

  16. The Power of Influence: School Nurse Stories.

    Science.gov (United States)

    Mazyck, Donna; Cellucci, Margaret; Largent, Piper

    2015-07-01

    School nurses have influence, and this influence is ignited with school nurse stories. School nurses must tell school staff, leaders, families, and students what they do to help students access their education. School boards, city councils, and legislators need to know the knowledge, skills, and judgment school nurses use daily. NASN understands that school nurses benefit from a "how to" kit and has developed tools to empower school nurses in advocating for their important role in supporting the health and learning of students. This article provides an overview this newly developed electronic toolkit while at the same time reinforcing the power of influence when sharing your stories. © 2015 The Author(s).

  17. European Success Stories in Industrial Mathematics

    CERN Document Server

    Esteban, Maria J; Lery, Thibaut; Maday, Yvon

    2011-01-01

    This unique book presents real world success stories of collaboration between mathematicians and industrial partners, showcasing first-hand case studies, and lessons learned from the experiences, technologies, and business challenges that led to the successful development of industrial solutions based on mathematics. It shows the crucial contribution of mathematics to innovation and to the industrial creation of value, and the key position of mathematics in the handling of complex systems, amplifying innovation. Each story describes the challenge that led to the industrial cooperation, how the

  18. The Engineering Project as Story and Narrative

    DEFF Research Database (Denmark)

    Henriksen, Lars Bo

    2012-01-01

    that the traditional project management tools are not always sufficient when it comes to managing engineering projects. In this chapter, an engineering project is examined, and it turns out that the language, the stories, and the narratives connected to the project is of greater importance to the engineers than...... the formal project management tools that were offered to the engineers. It also turns out that the term “project” could itself be a problem when it comes to fulfilling the project goals. Therefore, it is concluded that when working on engineering projects, language, stories, and narratives are just...

  19. Developer Stories: Improving Architecture in Agile Practice

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte; Jensen, Rolf Njor; Platz, Niels

    2007-01-01

    of viable architectures. To strengthen XP in this regard a new practice: Developer Stories ([2]) was introduced in 2006 - mainly based on a theoretical argumentation. This paper reports from extensive experimentation with, and elaboration of the new practice. Results from this experimentation shows...... that using Developer Stories increases the likelihood of developing a viable architecture through a series of deliberate choices, through creating disciplined and recurring activities that: 1) Facilitate sharing and embodying of knowledge about architectural issues, and 2) heighten visibility of refactorings...

  20. Stories and narratives in early childhood education

    Directory of Open Access Journals (Sweden)

    Jacqueline de Fatima dos Santos Morais

    2014-06-01

    Full Text Available This article discusses the importance of oral and written narrative for the maintenance of tradition and history of each one of us, in a society that seems to valorize the information more than the stories lived and told. It stresses the need, at school, of the teachers to read stories to children from early childhood education to boys and girls love to the world of literature. The text also contains situations en countered in schools that show the value of reading and the magic that literature provides in the lives of children.

  1. AHP 35: Under the Shadow: A Story

    Directory of Open Access Journals (Sweden)

    Huatse Gyal དཔའ་རྩེ་རྒྱལ།

    2015-02-01

    Full Text Available All through my schooling in Amdo, I admired the 'selfless soldiers' in the many stories that we were taught – stories that originated in the Chinese Communist revolution, and were supposed to provide the foundation for our new society, since the 1950s. Our heroes were modest, self-sacrificing, and thought only of the greater good of those around them. Comrade Lei Feng1 was one of those we admired most, especially in elementary school. At recess, the boys ran around with make-believe guns, pretending to be the exemplary and selfless soldiers we kept hearing about, willing to die because our country told us we should.

  2. Women stereotypes in Shi Zhecun's short stories.

    Science.gov (United States)

    Rosenmeier, Christopher

    2010-01-01

    This article analyses the representation of women in two 1933 short story collections by Shi Zhecun: An Evening of Spring Rain and Exemplary Conduct of Virtuous Women. It discusses how the New Woman image was a site of contestation in Republican China, and argues that Shi Zhecun’s short stories contain four basic stereotypes: the enigmatic woman, the estranged wife, the prostitute, and the inhibited woman. Using these narratives of women and how they were perceived by men, Shi Zhecun deconstructed the New Woman image by subverting the various ways modernity was projected onto women.

  3. Clinical development of Ebola vaccines

    Science.gov (United States)

    Sridhar, Saranya

    2015-01-01

    The ongoing outbreak of Ebola virus disease in West Africa highlighted the lack of a licensed drug or vaccine to combat the disease and has renewed the urgency to develop a pipeline of Ebola vaccines. A number of different vaccine platforms are being developed by assessing preclinical efficacy in animal models and expediting clinical development. Over 15 different vaccines are in preclinical development and 8 vaccines are now in different stages of clinical evaluation. These vaccines include DNA vaccines, virus-like particles and viral vectors such as live replicating vesicular stomatitis virus (rVSV), human and chimpanzee adenovirus, and vaccinia virus. Recently, in preliminary results reported from the first phase III trial of an Ebola vaccine, the rVSV-vectored vaccine showed promising efficacy. This review charts this rapidly advancing area of research focusing on vaccines in clinical development and discusses the future opportunities and challenges faced in the licensure and deployment of Ebola vaccines. PMID:26668751

  4. Can classic moral stories promote honesty in children?

    Science.gov (United States)

    Lee, Kang; Talwar, Victoria; McCarthy, Anjanie; Ross, Ilana; Evans, Angela; Arruda, Cindy

    2014-08-01

    The classic moral stories have been used extensively to teach children about the consequences of lying and the virtue of honesty. Despite their widespread use, there is no evidence whether these stories actually promote honesty in children. This study compared the effectiveness of four classic moral stories in promoting honesty in 3- to 7-year-olds. Surprisingly, the stories of "Pinocchio" and "The Boy Who Cried Wolf" failed to reduce lying in children. In contrast, the apocryphal story of "George Washington and the Cherry Tree" significantly increased truth telling. Further results suggest that the reason for the difference in honesty-promoting effectiveness between the "George Washington" story and the other stories was that the former emphasizes the positive consequences of honesty, whereas the latter focus on the negative consequences of dishonesty. When the "George Washington" story was altered to focus on the negative consequences of dishonesty, it too failed to promote honesty in children. © The Author(s) 2014.

  5. Story and Recall in First-Person Shooters

    Directory of Open Access Journals (Sweden)

    Dan Pinchbeck

    2008-01-01

    Full Text Available Story has traditionally been seen as something separate to gameplay—frequently relegated to an afterthought or epiphenomenon. Nevertheless, in the FPS genre there has been something of a renaissance in the notion of the story-driven title. Partially, this is due to advances in technology enabling a greater capacity for distributed storytelling and a better integration of story and gameplay. However, what has been underrecognised is the dynamic, epistemological, and psychological impact of story and story elements upon player behaviour. It is argued here that there is evidence that story may have a direct influence upon cognitive operations. Specifically, evidence is presented that it appears to demonstrate that games with highly visible, detailed stories may assist players in recalling and ordering their experiences. If story does, indeed, have a more direct influence, then it is clearly a more powerful and immediate tool in game design than either simply reward system or golden thread.

  6. More than pretty pictures? How illustrations affect parent-child story reading and children’s story recall

    Directory of Open Access Journals (Sweden)

    Andrea Follmer Greenhoot

    2014-07-01

    Full Text Available Previous research showed that story illustrations fail to enhance young preschoolers’ memories when they accompany a pre-recorded story (e.g., Greenhoot & Semb, 2008. In this study we tested whether young children might benefit from illustrations in a more interactive story-reading context. For instance, illustrations might influence parent-child reading interactions, and thus children’s story comprehension and recall. Twenty-six 3.5- to 4.5-year-olds and their primary caregivers were randomly assigned to an Illustrated or Non-Illustrated story-reading condition, and parents were instructed to read or tell the story as they normally would read with their child. Children recalled the story after a distracter and again after one week. Analyses of the story-reading interactions showed that the illustrations prompted more interactive story reading and more parent and child behaviors known to predict improved literacy outcomes. Furthermore,in the first memory interview, children in the Illustrated condition recalled more story events than those in the Non-Illustrated condition. Story reading measures predicted recall, but did not completely account for picture effects. These results suggest that illustrations enhance young preschoolers’ story recall in an interactive story reading context, perhaps because the joint attention established in this context supports children’s processing of the illustrations.

  7. The Human Hookworm Vaccine.

    Science.gov (United States)

    Hotez, Peter J; Diemert, David; Bacon, Kristina M; Beaumier, Coreen; Bethony, Jeffrey M; Bottazzi, Maria Elena; Brooker, Simon; Couto, Artur Roberto; Freire, Marcos da Silva; Homma, Akira; Lee, Bruce Y; Loukas, Alex; Loblack, Marva; Morel, Carlos Medicis; Oliveira, Rodrigo Correa; Russell, Philip K

    2013-04-18

    Hookworm infection is one of the world's most common neglected tropical diseases and a leading cause of iron deficiency anemia in low- and middle-income countries. A Human Hookworm Vaccine is currently being developed by the Sabin Vaccine Institute and is in phase 1 clinical testing. The candidate vaccine is comprised of two recombinant antigens known as Na-GST-1 and Na-APR-1, each of which is an important parasite enzyme required for hookworms to successfully utilize host blood as a source of energy. The recombinant proteins are formulated on Alhydrogel(®) and are being tested in combination with a synthetic Toll-like receptor 4 agonist. The aim of the vaccine is to induce anti-enzyme antibodies that will reduce both host blood loss and the number of hookworms attached to the gut. Transfer of the manufacturing technology to the Oswaldo Cruz Foundation (FIOCRUZ)/Bio-Manguinhos (a Brazilian public sector developing country vaccine manufacturer) is planned, with a clinical development plan that could lead to registration of the vaccine in Brazil. The vaccine would also need to be introduced in the poorest regions of Africa and Asia, where hookworm infection is highly endemic. Ultimately, the vaccine could become an essential tool for achieving hookworm control and elimination, a key target in the 2012 London Declaration on Neglected Tropical Diseases. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Pricing of new vaccines.

    Science.gov (United States)

    Lee, Bruce Y; McGlone, Sarah M

    2010-08-01

    New vaccine pricing is a complicated process that could have substantial long-standing scientific, medical, and public health ramifications. Pricing can have a considerable impact on new vaccine adoption and, thereby, either culminate or thwart years of research and development and public health efforts. Typically, pricing strategy consists of the following ten components: 1. Conduct a target population analysis; 2. Map potential competitors and alternatives; 3. Construct a vaccine target product profile (TPP) and compare it to projected or actual TPPs of competing vaccines; 4. Quantify the incremental value of the new vaccine's characteristics; 5. Determine vaccine positioning in the marketplace; 6. Estimate the vaccine price-demand curve; 7. Calculate vaccine costs (including those of manufacturing, distribution, and research and development); 8. Account for various legal, regulatory, third party payer, and competitor factors; 9. Consider the overall product portfolio; 10. Set pricing objectives; 11. Select pricing and pricing structure. While the biomedical literature contains some studies that have addressed these components, there is still considerable room for more extensive evaluation of this important area.

  9. Pricing of new vaccines

    Science.gov (United States)

    McGlone, Sarah M

    2010-01-01

    New vaccine pricing is a complicated process that could have substantial long-standing scientific, medical and public health ramifications. Pricing can have a considerable impact on new vaccine adoption and, thereby, either culminate or thwart years of research and development and public health efforts. Typically, pricing strategy consists of the following eleven components: (1) Conduct a target population analysis; (2) Map potential competitors and alternatives; (3) Construct a vaccine target product profile (TPP) and compare it to projected or actual TPPs of competing vaccines; (4) Quantify the incremental value of the new vaccine's characteristics; (5) Determine vaccine positioning in the marketplace; (6) Estimate the vaccine price-demand curve; (7) Calculate vaccine costs (including those of manufacturing, distribution, and research and development); (8) Account for various legal, regulatory, third party payer and competitor factors; (9) Consider the overall product portfolio; (10) Set pricing objectives; (11) Select pricing and pricing structure. While the biomedical literature contains some studies that have addressed these components, there is still considerable room for more extensive evaluation of this important area. PMID:20861678

  10. Acceptance of vaccination

    NARCIS (Netherlands)

    Lehmann, B.; Eilers, R.; Donken, R.; Barug, D.; Swillens, J.; Vriend, C. de; Weerdenburg, S.; Pot, M.; Keulen, H. van; Paulussen, T.; Vermey, K.; Alberts, N.; Marra, E.; Melker, H.E. de; Mollema, L.

    2016-01-01

    Both in 2013 and 2015 the mean intention of parents to vaccinate their child was high. Only 21% of parents reported making an informed decision about childhood vaccinations included in the NIP. Mass media attention on the use of allegedly inferior needles, which was later refuted, appeared to have a

  11. Vaccines Stop Illness

    Science.gov (United States)

    ... the disease no longer exists. If we keep vaccinating now, parents in the future may be able to trust that diseases like polio and meningitis won't infect, cripple, or kill children. Vaccine Safety In light of recent questions about ...

  12. Chimeric Pestivirus Experimental Vaccines.

    Science.gov (United States)

    Reimann, Ilona; Blome, Sandra; Beer, Martin

    2016-01-01

    Chimeric pestiviruses have shown great potential as marker vaccine candidates against pestiviral infections. Exemplarily, we describe here the construction and testing of the most promising classical swine fever vaccine candidate "CP7_E2alf" in detail. The description is focused on classical cloning technologies in combination with reverse genetics.

  13. Teaching English Using Local Culture Content Short Story

    OpenAIRE

    Sanda, Silfi

    2009-01-01

    This paper is mainly about the use of local culture content short story in developing students' English proficiency and some activities that can be employed for this purpose. The local culture exposed in the short story is the traditional woven clothes of Palembang, Songket in term of process and product. The short story used in this topic is Cek Ipah "The Palembang Songket Weaver". This short story is authors' original work telling about everyday live of palembang songket weaver which covers...

  14. Vaccination Perceptions of College Students: With and without Vaccination Waiver.

    Science.gov (United States)

    Jadhav, Emmanuel D; Winkler, Danielle L; Anderson, Billie S

    2018-01-01

    The resurgence of vaccine preventable diseases occurs more often among intentionally unvaccinated individuals, placing at direct risk young adults not caught up on vaccinations. The objectives of this study were to characterize the sociodemographic characteristics of young adults with and without vaccination waivers and identify their perceived benefits, barriers, and influencers of vaccination. Young adults ( n  = 964) from a Midwestern rural university responded to a survey (fall 2015-spring 2016) designed to identify their perception toward vaccination. Instrument consistency was measured using the Cronbach α-scores. The Chi-square test was used to test any sociodemographic differences and Mann-Whitney U -tests results for differences between exempt and non-exempt students. Analysis occurred in spring 2017. A little over one-third of young adults with a vaccination waiver were not up to date on their vaccinations, and think that vaccinations can cause autism. The biggest identifiable benefit was effective control against disease. The surveyed young adults ranked the out of pocket cost associated with vaccination as the most important barrier and safe and easy to use vaccines as the most important influencer of vaccination. Young adults who have had a vaccination waiver appear to not be up to date on their vaccinations. Vaccine administration programs, such as university campus clinics, would benefit from addressing perceptions unique to young adults with and without a vaccine waiver. This would subsequently better provide young adults a second shot for getting appropriately caught up on vaccinations.

  15. DNA fusion gene vaccines

    DEFF Research Database (Denmark)

    Holst, Peter Johannes; Bassi, Maria Rosaria; Thomsen, Allan Randrup

    2010-01-01

    DNA vaccines are versatile and safe, but limited immunogenicity has prevented their use in the clinical setting. Experimentally, immunogenicity may be enhanced by the use of new delivery technologies, by coadministration of cytokines and pathogen-associated molecular patterns, or by fusion...... of antigens into molecular domains that enhance antigen presentation. More specifically, the immunogenicity of DNA vaccines may benefit from increased protein synthesis, increased T-cell help and MHC class I presentation, and the addition of a range of specific cytokines and pathogen-associated molecular...... with viral-vectored vaccines, various synergistic components may need to be incorporated into DNA vaccines. From the perspective of the future clinical use of DNA vaccines, it has been suggested that antigen presentation should be improved and cytokine coadministration attempted. However, even...

  16. Financing children's vaccines.

    Science.gov (United States)

    Nelson, E Anthony S; Sack, David; Wolfson, Lara; Walker, Damian G; Seng, Lim Fong; Steele, Duncan

    2009-11-20

    A 2006 Commonwealth Association of Paediatric Gastroenterology and Nutrition workshop on financing children's vaccines highlighted the potential for vaccines to control diarrhoea and other diseases as well as spur economic development through better health. Clear communication of vaccination value to decision-makers is required, together with sustainable funding mechanisms. GAVI and partners have made great progress providing funding for vaccines for children in the poorest countries but other solutions may be required to achieve the same gains in middle- and high-income countries. World Health Organization has a wealth of freely available country-level data on immunisation that academics and advocates can use to communicate the economic and health benefits of vaccines to decision-makers.

  17. Next generation vaccines.

    Science.gov (United States)

    Riedmann, Eva M

    2011-07-01

    In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

  18. The Power of Fiction: Reading Stories in Abnormal Psychology

    Science.gov (United States)

    Janit, Adrian S.; Hammock, Georgina S.; Richardson, Deborah S.

    2011-01-01

    We compared the instructional efficacy of a narrative text (i.e., a story) and an expository text (i.e., a textbook excerpt). Students enrolled in Abnormal Psychology classes read about the disorder, "dissociative fugue" from a story, a textbook, or both. The story contained literary elements that increased transportation into the story…

  19. Fostering Healthy Transitions: Honouring the Healing Power of Stories

    OpenAIRE

    Hogan, Fergus

    2000-01-01

    Ireland has a long tradition of storytelling. We create our identity through the stories we tell of ourselves in a narrative approach to becomming who we were born to be. This paper uses the story of Fionn Mac Cumhaill as a way of honouring the stories children bring with them when they come into care or live in foster families.

  20. Short stories (Translated by G. Sumeli Weinberg | Nove | Italian ...

    African Journals Online (AJOL)

    Aldo Nove, the nom de plum of Antonello Satta Centanin, was born on Viggiù in the province of Varese in 1967. Musician, poet and writer, his first collection of short stories Woobinda e altre storie senza lieto fine (Woobinda and Other Stories Without a Happy Ending) was published in 1996 and two years later it was ...

  1. Trying to Teach Well: A Story of Small Discoveries

    Science.gov (United States)

    Lewis, P. J.

    2004-01-01

    ''Stories do not simply contain knowledge, they are themselves the knowledge'' (Jackson (In: K. Eagan, H. McEwan (Eds.), Narrative in Teaching, Learning and Research, Teacher College Press, New York, 1995, p. 5)). How can we teach well? Perhaps we can find answers through our stories from the classroom. It is through our stories that we make sense…

  2. Composing Storied Ground: Four Generations of Narrative Inquiry

    Science.gov (United States)

    Schaafsma, David; Pagnucci, Gian; Wallace, Rob; Stock, Patricia Lambert

    2007-01-01

    Narrative inquiry in English education comes in many shapes and forms--tales of classrooms and communities, didactic argu-stories, postmodern pastiches, open tales with O. Henry endings--but the heart of the enterprise is research in the form of story or, in other words, exploring the world by telling a story about it. In many such tales, all of…

  3. Non-Linear Interactive Stories in Computer Games

    DEFF Research Database (Denmark)

    Bangsø, Olav; Jensen, Ole Guttorm; Kocka, Tomas

    2003-01-01

    The paper introduces non-linear interactive stories (NOLIST) as a means to generate varied and interesting stories for computer games automatically. We give a compact representation of a NOLIST based on the specification of atomic stories, and show how to build an object-oriented Bayesian network...

  4. Stories, Proverbs, and Anecdotes as Scaffolds for Learning Science Concepts

    Science.gov (United States)

    Mutonyi, Harriet

    2016-01-01

    Few research studies in science education have looked at how stories, proverbs, and anecdotes can be used as scaffolds for learning. Stories, proverbs, and anecdotes are cultural tools used in indigenous communities to teach children about their environment. The study draws on Bruner's work and the theory of border crossing to argue that stories,…

  5. HIV vaccines: new frontiers in vaccine development.

    Science.gov (United States)

    Duerr, Ann; Wasserheit, Judith N; Corey, Lawrence

    2006-08-15

    A human immunodeficiency virus (HIV) vaccine is the most promising and feasible strategy to prevent the events during acute infection that simultaneously set the course of the epidemic in the community and the course of the disease for the individual. Because safety concerns limit the use of live, attenuated HIV and inactivated HIV, a variety of alternate approaches is being investigated. Traditional antibody-mediated approaches using recombinant HIV envelope proteins have shown no efficacy in 2 phase III trials. Current HIV vaccine trials are focusing primarily on cytotoxic T lymphocyte-mediated products that use viral vectors, either alone or as boosts to DNA plasmids that contain viral genes. The most immunogenic of these products appear to be the recombinant adenovirus vector vaccines, 2 of which are now in advanced clinical development.

  6. The Story of Story Mill-A Montana Community Working to Restore Wetlands

    Science.gov (United States)

    Story Mill, a 55-acre site on the outskirts of Bozeman, Montana, has undergone several transformations in recent history. The place is virtually a “mill of stories” with respect to land use, but originally it was a wetland.

  7. My Bar Graph Tells a Story

    Science.gov (United States)

    McMillen, Sue; McMillen, Beth

    2010-01-01

    Connecting stories to qualitative coordinate graphs has been suggested as an effective instructional strategy. Even students who are able to "create" bar graphs may struggle to correctly "interpret" them. Giving children opportunities to work with qualitative graphs can help them develop the skills to interpret, describe, and compare information…

  8. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,353 views 5: ... Little Stars 13,224 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  9. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,265 views 5: ... Little Stars 13,224 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  10. Atoms stories; Histoire d`atomes

    Energy Technology Data Exchange (ETDEWEB)

    Radvanyi, P; Bordry, M [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France)

    1988-12-31

    Physicists from different countries told each evening during one learning week, to an audience of young people, some great discoveries in evoking the difficulties and problems to which the researchers were confronted. From Antiquity to a more recent history, it is a succession of atoms stories. (N.C.)

  11. Extraordinary Readers: The Story of a Documentary

    Directory of Open Access Journals (Sweden)

    İsmail Arayıcı

    2013-11-01

    Full Text Available This article discusses the story behind the making of a documentary about the extraordinary patrons of public libraries located throughout Turkey. The documentary explored in this article was the result of collaboration between the Libraries of the Ministry of Culture and Tourism, the General Directorate of Libraries and Publications, and the Turkish Librarians' Association.

  12. From Storyboard to Story: Animation Content Development

    Science.gov (United States)

    Mou, Tsai-Yun; Jeng, Tay-Sheng; Chen, Chien-Hsu

    2013-01-01

    This research focused on a new method in the development of animation story content, which could shorten the creation process and arouse new ideas. Two phases of experiments were conducted to explore this reversed model. The first phase is a pretest of participants' creativity, which was a base for further examination the relationship between…

  13. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,056 views 5: ... Little Stars 12,980 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  14. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,934 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  15. Glimpses of a Century-Old Story

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 4. Glimpses of a Century-Old Story - Agrobacterium, a Pathogen Deployed for Genetic Engineering. Jasmine M Shah. General Article Volume 18 Issue 4 April 2013 pp 336-344 ...

  16. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,668 views 5: ... Little Stars 12,587 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  17. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 13:34 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,265 views 5: ... University (NEOMED) 27,094 views 5:39 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  18. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,898 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  19. Peer Mentoring: Stories of Three Mathematics Teachers

    Science.gov (United States)

    Kensington-Miller, Barbara

    2011-01-01

    Mentoring is a professional development strategy well documented. Peer mentoring however, is relatively new and was provided as a professional development strategy for a group of secondary school mathematics teachers working in low socio-economic schools. Through the stories of three teachers, the year-long study identifies the features critical…

  20. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,265 views 5: ... University (NEOMED) 26,879 views 5:39 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  1. Stories in Different Domains of Child Development

    Science.gov (United States)

    Gnjatovic, Dragana

    2015-01-01

    This article is based on the results gained from the research about the perception teachers have about stories. The study was conducted in Sweden and the main purpose was to partially fulfil the requirements for Erasmus Mundus joint degree "International Master of Early Childhood Education and Care". In accordance with previous research…

  2. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... Health - Meriter 252,222 views 13:34 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer Program - Duration: 11:08. UCLA Health 268,713 ... views 5:27 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,186 views 5: ...

  3. Defense Threat Reduction Agency > Success Stories

    Science.gov (United States)

    History Documents US Underground Nuclear Test History Reports NTPR Radiation Exposure Reports Enewetak Atoll Cleanup Documents TRAC About Who We Are Our Values History Locations Our Leadership Director Support Center Contact Us FAQ Sheet Links Success Stories Contracts Business Opportunities Current

  4. A Compendium of Energy Conservation Success Stories

    Science.gov (United States)

    1988-09-01

    Three-quarters of DOE's Conservation R and D funds have been devoted to technology research and development: basic and applied research, exploratory R and D, engineering feasibility studies, pilot-scale prototype R and D, and technology demonstration. Non R and D projects have involved technology assessment program planning and analysis, model development, technology transfer and consumer information, health effects and safety research, and technical support for rule making. The success stories summarized in this compendium fall into three general categories: Completed Technology Success Stories, projects that have resulted in new energy-saving technologies that are presently being used in the private sector; Technical Success Stories, projects that have produced or disseminated important scientific/technical information likely to result in future energy savings; Program Success Stories, non-R and D activities that have resulted in nationally significant energy benefits. The Energy Conservation research and development program at DOE is managed by the Office of Conservation under the direction of the Deputy Assistant Secretary for Conservation. Three subordinate Program Offices correspond to the buildings, transportation, and industrial end-use sectors. A fourth subordinate Program Office{endash}Energy Utilization Research{endash}sponsors research and technical inventions for all end-use sectors.

  5. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 5:39 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,489 views 5: ... 7:18 Sevanah Marecle's Story - Another child fighting cancer - Duration: 4:13. John Gavin 49,508 views ...

  6. Telling Mathematical Stories with Live Editing

    Science.gov (United States)

    Thomson, Ian

    2017-01-01

    Using "live editing" it is possible to write code that can be run a section at a time. This makes it easier to spot and correct errors. It can also be used to create an interactive mathematical story. This brief article shows how MATLAB software can be used to take the user on a mathematical journey with historical connections.

  7. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,044 views 5: ... University (NEOMED) 26,562 views 5:39 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  8. The Story of the Trojan Octagon

    Science.gov (United States)

    Derado, Josip; Garner, Mary; Edwards, Belinda P.; Garrett, Violette L.

    2010-01-01

    Stories that are presented through literature or popular media can be used to invite students into the world of math; stir their mathematical imaginations; and enhance their ability to read about, write about, and discuss math. This article explores how literature ("Flatland," the book and the movie) and an existing seventh-grade unit…

  9. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,988 views 5: ... University (NEOMED) 26,434 views 5:39 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  10. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 12:07 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,703 views 5: ... 24. RileyKidsVideo 210,660 views 4:24 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  11. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show less ... 35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer Program - Duration: 11:08. UCLA Health ...

  12. Elizabeth Belle’s Birth Story

    Science.gov (United States)

    Boro, Jessica; Boro, Samuel

    2014-01-01

    In this article, Jessica and Samuel Boro share the story of the birth of their daughter, Elizabeth Belle. With the physical and emotional support of her husband and her doula, this mother was able to cope with a long labor and have the natural birth she wanted. Her husband describes how important the doula was for him. PMID:25364215

  13. Stories of Human Autonomy, Law, and Technology

    Science.gov (United States)

    Tranter, Kieran

    2010-01-01

    Considering the relationship between human autonomy, law and technology has deep origins. Both technology studies and legal theory tell origin stories about human autonomy as the prize from either a foundational technological or jurisprudential event. In these narratives either law is considered a second order consequence of technology or…

  14. A compendium of energy conservation success stories

    Energy Technology Data Exchange (ETDEWEB)

    1988-09-01

    Three-quarters of DOE's Conservation R and D funds have been devoted to technology research and development: basic and applied research, exploratory R and D, engineering feasibility studies, pilot-scale prototype R and D, and technology demonstration. Non R and D projects have involved technology assessment program planning and analysis, model development, technology transfer and consumer information, health effects and safety research, and technical support for rule making. The success stories summarized in this compendium fall into three general categories: Completed Technology Success Stories, projects that have resulted in new energy-saving technologies that are presently being used in the private sector; Technical Success Stories, projects that have produced or disseminated important scientific/technical information likely to result in future energy savings; Program Success Stories, non-R and D activities that have resulted in nationally significant energy benefits. The Energy Conservation research and development program at DOE is managed by the Office of Conservation under the direction of the Deputy Assistant Secretary for Conservation. Three subordinate Program Offices correspond to the buildings, transportation, and industrial end-use sectors. A fourth subordinate Program Office/endash/Energy Utilization Research/endash/sponsors research and technical inventions for all end-use sectors.

  15. Global Stories of People Working for Change.

    Science.gov (United States)

    Dragman, June; Szasz, Michael

    Developed by a Canadian volunteer organization, this textbook for high school and adult English-as-a-Second-Language (ESL) and literacy students explores current international events and social issues using both personal and global perspectives. It includes personal stories of people's lives, discussions of social and political issues in a wider…

  16. Mathematical History: Activities, Puzzles, Stories, and Games.

    Science.gov (United States)

    Mitchell, Merle

    Based on the history of mathematics, these materials have been planned to enrich the teaching of mathematics in grades four, five, and six. Puzzles and games are based on stories about topics such as famous mathematicians, numerals of ancient peoples, and numerology. The sheets are arranged by grade level and are designed for easy duplication.…

  17. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 5:39 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,265 views 5: ... Before Death 17,437 views 5:27 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  18. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,915 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  19. Generosity and Hospitality in Christmas Story

    NARCIS (Netherlands)

    Laine, T.

    2013-01-01

    This short subject discusses what might be understood as Santa Claus’ essence, which is the logic of and limits to his overarching generosity, as depicted in the film Christmas Story (Wuolijoki, 2007). The plot centres on the orphan Nikolas, who grew up to be Santa Claus. Young Nikolas moves to a

  20. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,941 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  1. Resistance Stories of African-Brazilian Women

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    2005-01-01

    Full Text Available This study consists of an intervention using narrative workshops as a device to stimulate the empowerment of women. Ten women, victims of gender violence, took part in a workshop developed by non-governmental organization for African-Brazilian women Maria Mulher, which gives assistance to women living in Vila Cruzeiro do Sul, in the city of Porto Alegre. The main objective of the research was to debate questions related to gender and violence, making use of stories and histories related to the feminine, specifically African-Brazilian stories. Five meetings were held, where the women told and were told stories, took part in group discussions, experiences and rituals. The workshops gave those women a space where they could tell and hear stories, take part in the rituals of the orixás [African-Brazilian deities] of the black culture and tell their personal histories using those experiences. This intervention was an attempt at invoking different subjective experiences, and made it possible to empower the women who took part in the research, contributing for the rescue of the individual and collective memory of this group.

  2. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show ...

  3. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 5:27 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,353 views 5: ... Stars 13,224 views 10:35 Cheyenne's Childhood Cancer Story - Duration: 3:10. St. Baldrick's Foundation 115, ...

  4. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,015 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  5. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... watching Live now The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,459 views 5: ... 06. HCFAQuality 31,318 views 3:06 Phoebe's Cancer Story - Duration: 7:46. Family A-Fair 774, ...

  6. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... Little Stars 12,587 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer Program - Duration: 11:08. UCLA Health 264,219 views 11:08 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,651 views 5: ...

  7. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,036 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  8. The anthrax letters: a medical detective story

    National Research Council Canada - National Science Library

    Cole, Leonard A

    2003-01-01

    .... Library of Congress Cataloging-in-Publication Data Cole, Leonard A., 1933The anthrax letters : a medical detective story / Leonard A. Cole. p. cm. Includes bibliographical references and index. ISBN 0-309-08881-X - ISBN 0-309-52584-5 (PDF) 1. Bioterrorism- United States. 2. Anthrax- United States. 3. Postal service- United States. 4. Victims of...

  9. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,972 views 5: ... Little Stars 12,759 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  10. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,958 views 5: ... Tammy Ziegler 144,925 views 5:08 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  11. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... stop Loading... Watch Queue Queue __count__/__total__ It’s YouTube. Uninterrupted. Loading... Want music and videos with zero ... 35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer Program - Duration: 11:08. UCLA Health ...

  12. Pediatric Palliative Care: A Personal Story

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  13. Thoughts on Selecting a Short Story Anthology.

    Science.gov (United States)

    Logsdon, Loren

    2003-01-01

    Shares with beginning teachers advice about choosing a short story anthology and shows how a text can shape an instructor's approach to teaching short fiction. Discusses three main considerations: the students; the teacher; and the text. Identifies the author's favorite anthology and outlines nine reasons why it is a favorite. Lists five…

  14. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 10:35 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,489 views 5: ... 5:39 Sevanah Marecle's Story - Another child fighting cancer - Duration: 4:13. John Gavin 49,508 views ...

  15. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 13:34 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,175 views 5: ... Jester 160,437 views New 12:43 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  16. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,612 views 5: ... Little Stars 12,587 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  17. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 5:27 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,265 views 5: ... Health - Meriter 253,329 views 13:34 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  18. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 4:24 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 63,738 views 5: ... Little Stars 12,680 views 10:35 Teen Cancer Stories | UCLA Daltrey/Townshend Teen & Young Adult Cancer ...

  19. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... views 2:50 The Ugly Truth of Pediatric Cancer - Duration: 5:21. KidsCancerChannel 64,459 views 5:21 Sevanah Marecle's Story - Another child fighting cancer - Duration: 4:13. John Gavin 49,508 views ...

  20. Laser vaccine adjuvants

    Science.gov (United States)

    Kashiwagi, Satoshi; Brauns, Timothy; Gelfand, Jeffrey; Poznansky, Mark C

    2014-01-01

    Immunologic adjuvants are essential for current vaccines to maximize their efficacy. Unfortunately, few have been found to be sufficiently effective and safe for regulatory authorities to permit their use in vaccines for humans and none have been approved for use with intradermal vaccines. The development of new adjuvants with the potential to be both efficacious and safe constitutes a significant need in modern vaccine practice. The use of non-damaging laser light represents a markedly different approach to enhancing immune responses to a vaccine antigen, particularly with intradermal vaccination. This approach, which was initially explored in Russia and further developed in the US, appears to significantly improve responses to both prophylactic and therapeutic vaccines administered to the laser-exposed tissue, particularly the skin. Although different types of lasers have been used for this purpose and the precise molecular mechanism(s) of action remain unknown, several approaches appear to modulate dendritic cell trafficking and/or activation at the irradiation site via the release of specific signaling molecules from epithelial cells. The most recent study, performed by the authors of this review, utilized a continuous wave near-infrared laser that may open the path for the development of a safe, effective, low-cost, simple-to-use laser vaccine adjuvant that could be used in lieu of conventional adjuvants, particularly with intradermal vaccines. In this review, we summarize the initial Russian studies that have given rise to this approach and comment upon recent advances in the use of non-tissue damaging lasers as novel physical adjuvants for vaccines. PMID:25424797

  1. Vaccines for canine leishmaniasis

    Directory of Open Access Journals (Sweden)

    Clarisa B. Palatnik-De-Sousa

    2012-04-01

    Full Text Available Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global-warming, co-infection with immunosuppressive diseases and poverty. The disease is an anthroponosis in India and Central Africa and a canid zoonosis (ZVL in the Americas, the Middle East, Central Asia, China and the Mediterranean. The ZVL epidemic has been controlled by one or more measures including the culling of infected dogs, treatment of human cases and insecticidal treatment of homes and dogs. However, the use of vaccines is considered the most cost-effective control tool for human and canine disease. Since the severity of the disease is related to the generation of T-cell immunosuppression, effective vaccines should be capable of sustaining or enhancing the T-cell immunity. In this review we summarize the clinical and parasitological characteristics of ZVL with special focus on the cellular and humoral canine immune response and review state-of-the-art vaccine development against human and canine visceral leishmaniasis. Experimental vaccination against leishmaniasis has evolved from the practice of leishmanization with living parasites to vaccination with crude lysates, native parasite extracts to recombinant and DNA vaccination. Although more than 30 defined vaccines have been studied in laboratory models no human formulation has been licensed so far; however three second-generation canine vaccines have already been registered. As expected for a zoonotic disease, the recent preventive vaccination of dogs in Brazil has led to a reduction in the incidence of canine and human disease. The recent identification of several Leishmania proteins with T-cell epitopes anticipates development of a multiprotein vaccine that will be capable of protecting both humans

  2. Performance-Based Seismic Retrofit of Soft-Story Woodframe Buildings

    Science.gov (United States)

    P. Bahmani; J.W. van de Lindt; S.E. Pryor; G.L. Mochizuki; M. Gershfeld; D. Rammer; J. Tian; D. Symans

    2013-01-01

    Soft-story woodframe buildings are recognizable by their large garage openings at the bottom story which are typically for parking and storage. In soft-story buildings the relative stiffness and strength of the soft-story, usually the bottom story, is significantly less than the upper stories due to the presence of large openings which reduce the available space for...

  3. Vaccination in food allergic patients

    African Journals Online (AJOL)

    Most people do not react to vaccination and the incidence of vaccine anaphylaxis is estimated to be <1/million for all vaccines.[1] Most anaphylactic reactions occur in non-food allergic children. It is strongly recommended that anyone admin- istering vaccines has resuscitation equipment available to manage potential ...

  4. Parental knowledge of paediatric vaccination

    Directory of Open Access Journals (Sweden)

    Borràs Eva

    2009-05-01

    Full Text Available Abstract Background Although routine vaccination is a major tool in the primary prevention of some infectious diseases, there is some reluctance in a proportion of the population. Negative parental perceptions of vaccination are an important barrier to paediatric vaccination. The aim of this study was to investigate parental knowledge of paediatric vaccines and vaccination in Catalonia. Methods A retrospective, cross-sectional study was carried out in children aged Results An association was observed between greater vaccination coverage of the 4:4:4:3:1 schedule (defined as: 4 DTPa/w doses, 4 Hib doses, 4 OPV doses, 3 MenC doses and 1 MMR dose and maternal age >30 years (OR: 2.30; 95% CI: 1.20–4.43 and with a knowledge of vaccination score greater than the mean (OR: 0.45; 95% CI: 0.28–0.72. The score increased with maternal educational level and in parents of vaccinated children. A total of 20.47% of parents stated that vaccines could have undesirable consequences for their children. Of these, 23.26% had no specific information and 17.83% stated that vaccines can cause adverse reactions and the same percentage stated that vaccines cause allergies and asthma. Conclusion Higher vaccination coverage is associated with older maternal age and greater knowledge of vaccination. Vaccination coverage could be raised by improving information on vaccines and vaccination.

  5. Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.

    Science.gov (United States)

    He, Yongqun; Xiang, Zuoshuang

    2010-09-27

    Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal vaccines are available, there is no effective and safe vaccine for prevention of brucellosis in humans. VIOLIN (http://www.violinet.org) is a web-based vaccine database and analysis system that curates, stores, and analyzes published data of commercialized vaccines, and vaccines in clinical trials or in research. VIOLIN contains information for 454 vaccines or vaccine candidates for 73 pathogens. VIOLIN also contains many bioinformatics tools for vaccine data analysis, data integration, and vaccine target prediction. To demonstrate the applicability of VIOLIN for vaccine research, VIOLIN was used for bioinformatics analysis of existing Brucella vaccines and prediction of new Brucella vaccine targets. VIOLIN contains many literature mining programs (e.g., Vaxmesh) that provide in-depth analysis of Brucella vaccine literature. As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective Brucella antigens, and 68 host response studies to Brucella vaccines from 97 peer-reviewed articles. These Brucella vaccines are classified in the Vaccine Ontology (VO) system and used for different ontological applications. The web-based VIOLIN vaccine target prediction program Vaxign was used to predict new Brucella vaccine targets. Vaxign identified 14 outer membrane proteins that are conserved in six virulent strains from B. abortus, B. melitensis, and B. suis that are pathogenic in humans. Of the 14 membrane proteins, two proteins (Omp2b and Omp31-1) are not present in B. ovis, a Brucella species that is not pathogenic in humans. Brucella vaccine data stored in VIOLIN were compared and analyzed using the VIOLIN query system. Bioinformatics curation and ontological representation of Brucella vaccines

  6. [Current events in vaccination].

    Science.gov (United States)

    Aubert, M; Aumaître, H; Beytout, J; Bloch, K; Bouhour, D; Callamand, P; Chave, C; Cheymol, J; Combadière, B; Dahlab, A; Denis, F; De Pontual, L; Dodet, B; Dommergues, M-A; Dufour, V; Gagneur, A; Gaillat, J; Gaudelus, J; Gavazzi, G; Gillet, Y; Gras-le-Guen, C; Haas, H; Hanslik, T; Hau-Rainsard, I; Larnaudie, S; Launay, O; Lorrot, M; Loulergue, P; Malvy, D; Marchand, S; Picherot, G; Pinquier, D; Pulcini, C; Rabaud, C; Regnier, F; Reinert, P; Sana, C; Savagner, C; Soubeyrand, B; Stephan, J-L; Strady, C

    2011-11-01

    The annual meeting of the Infectious Disease Society of America (IDSA) ; which brought together nearly 5000 participants from over 80 countries in Vancouver, Canada, October 21 to 24, 2010 ; provided a review of the influenza (H1N1) 2009 pandemic, evaluated vaccination programmes and presented new vaccines under development. With 12,500 deaths in the United States in 2009-2010, the influenza (H1N1) 2009 pandemic was actually less deadly than the seasonal flu. But it essentially hit the young, and the toll calculated in years of life lost is high. The monovalent vaccines, whether live attenuated or inactivated with or without adjuvants, were well tolerated in toddlers, children, adults and pregnant women. In order to protect infants against pertussis, family members are urged to get their booster shots. The introduction of the 13-valent Pneumococcal conjugated vaccine in the beginning of 2010 may solve - but for how long ? - the problem of serotype replacement, responsible for the re-increasing incidence of invasive Pneumococcal infections observed in countries that had introduced the 7-valent vaccine. The efficacy of a rotavirus vaccine has been confirmed, with a reduction in hospitalization in the United States and a reduction in gastroenteritis-related deaths in Mexico. In the United States, vaccination of pre-adolescents against human papillomavirus (HPV) has not resulted in any specific undesirable effects. Routine vaccination against chicken pox, recommended since 1995, has not had an impact on the evolution of the incidence of shingles. Vaccination against shingles, recommended in the United States for subjects 60 years and over, shows an effectiveness of 55 %, according to a cohort study (Kaiser Permanente, Southern California). Although some propose the development of personalized vaccines according to individual genetic characteristics, the priority remains with increasing vaccine coverage, not only in infants but also in adults and the elderly. Vaccine

  7. Technical Transformation of Biodefense Vaccines

    Science.gov (United States)

    Lu, Shan; Wang, Shixia

    2013-01-01

    Biodefense vaccines are developed against a diverse group of pathogens. Vaccines were developed for some of these pathogens a long time ago but they are facing new challenges to move beyond the old manufacturing technologies. New vaccines to be developed against other pathogens have to determine whether to follow traditional vaccination strategies or to seek new approaches. Advances in basic immunology and recombinant DNA technology have fundamentally transformed the process of formulating a vaccine concept, optimizing protective antigens, and selecting the most effective vaccine delivery approach for candidate biodefense vaccines. PMID:19837293

  8. Progress towards a Leishmania vaccine.

    Science.gov (United States)

    Tabbara, Khaled S

    2006-07-01

    Leishmaniasis is a vector-born protozoan disease. Approximately 12 million individuals are affected worldwide with an estimated annual incidence of 1.5-2 million. Two clinical manifestations are recognized, cutaneous, and visceral, both of which are common in the Middle East. In both forms, infection is chronic, with potential deformities, persistence following cure, and lifelong risk of reactivation. Attempts to develop an effective human Leishmania vaccine have not yet succeeded. Leishmanization, a crude form of live vaccination historically originated in this part of the world. Experimental vaccination has been extensively studied in model animals in the past 2 decades. In this review, major human killed vaccine trials are surveyed, and modern trends in Leishmania vaccine development, including subunit vaccines, naked DNA vaccines, and transmission blocking vaccines are explored. Recent findings of a link between persistence of live parasites, and maintenance of long-term immunity suggest live vaccination with attenuated strains, as a future vaccination strategy.

  9. 45 King: A Story of the Southern Home

    OpenAIRE

    Deluca, Paul Matthew Webb

    2014-01-01

    The house at 45 King St. in Charleston, South Carolina is more than a home. It is a story of the home. A story told through history, through a vision exhibited in architectural drawings, and through the social heritage closest to my heart. 45 King is a story for the South; the story of its grandeur, its climate, its natural beauty, its hospitality, its comfort, and its veils. It is a story that was told yesterday and one that is still told today. Like an oral history, the telling of it may...

  10. Book Review of Love Story Written by Erich Segal

    OpenAIRE

    Handayani, Candra

    2015-01-01

    In this study, the writer will analyze the novel Love Story by Erich Segal by using the intrinsic theories. The purposes of this study are to analyze the main characters and toreveal the strengths and the weaknesses of Erich Segal‟s Love Story. Love Story tells aromantic story of two main characters, Oliver Barret IV and Jennifer Cavileri who arefrom different social and culture background. Although Love Story has some weaknesses,the strengths of this novel make it still be recommended to be ...

  11. [Development of current smallpox vaccines].

    Science.gov (United States)

    Maksiutov, R A; Gavrilova, E V; Shchelkunov, S N

    2011-01-01

    The review gives data on the history of smallpox vaccination and shows the high topicality of designing the current safe vaccines against orthopoxviruses. Four generations of live smallpox, protein subunit, and DNA vaccines are considered. Analysis of the data published leads to the conclusion that it is promising to use the up-to-date generations of safe smallpox subunit or DNA vaccines for mass primary immunization with possible further revaccination with classical live vaccine.

  12. Development and initial feedback about a human papillomavirus (HPV) vaccine comic book for adolescents.

    Science.gov (United States)

    Katz, Mira L; Oldach, Benjamin R; Goodwin, Jennifer; Reiter, Paul L; Ruffin, Mack T; Paskett, Electra D

    2014-06-01

    Human papillomavirus (HPV) vaccination rates do not meet the Healthy People 2020 objective of 80% coverage among adolescent females. We describe the development and initial feedback about an HPV vaccine comic book for young adolescents. The comic book is one component of a multilevel intervention to improve HPV vaccination rates among adolescents. Parents suggested and provided input into the development of a HPV vaccine comic book. Following the development of the comic book, we conducted a pilot study to obtain initial feedback about the comic book among parents (n = 20) and their adolescents ages 9 to 14 (n = 17) recruited from a community-based organization. Parents completed a pre-post test including items addressing HPV knowledge, HPV vaccine attitudes, and about the content of the comic book. Adolescents completed a brief interview after reading the comic book. After reading the comic book, HPV knowledge improved (2.7 to 4.6 correct answers on a 0-5 scale; p book's content was acceptable and adolescents liked the story, found it easy to read, and thought the comic book was a good way to learn about being healthy. Parents provided valuable information in the development of a theoretically-based comic book and the comic book appears to be an acceptable format for providing HPV vaccine information to adolescents. Future research will include the comic book in an intervention study to improve HPV vaccination rates.

  13. Therapeutic HIV Peptide Vaccine

    DEFF Research Database (Denmark)

    Fomsgaard, Anders

    2015-01-01

    Therapeutic vaccines aim to control chronic HIV infection and eliminate the need for lifelong antiretroviral therapy (ART). Therapeutic HIV vaccine is being pursued as part of a functional cure for HIV/AIDS. We have outlined a basic protocol for inducing new T cell immunity during chronic HIV-1...... infection directed to subdominant conserved HIV-1 epitopes restricted to frequent HLA supertypes. The rationale for selecting HIV peptides and adjuvants are provided. Peptide subunit vaccines are regarded as safe due to the simplicity, quality, purity, and low toxicity. The caveat is reduced immunogenicity...

  14. Cellular based cancer vaccines

    DEFF Research Database (Denmark)

    Hansen, M; Met, Ö; Svane, I M

    2012-01-01

    Cancer vaccines designed to re-calibrate the existing host-tumour interaction, tipping the balance from tumor acceptance towards tumor control holds huge potential to complement traditional cancer therapies. In general, limited success has been achieved with vaccines composed of tumor...... to transiently affect in vitro migration via autocrine receptor-mediated endocytosis of CCR7. In the current review, we discuss optimal design of DC maturation focused on pre-clinical as well as clinical results from standard and polarized dendritic cell based cancer vaccines....

  15. ADE and dengue vaccination.

    Science.gov (United States)

    Martínez-Vega, Ruth Aralí; Carrasquila, Gabriel; Luna, Expedito; Ramos-Castañeda, José

    2017-07-13

    The vaccine against Dengue virus (DENV), Dengvaxia® (CYD), produced by Sanofi-Pasteur, has been registered by several national regulatory agencies; nevertheless, the performance and security of this vaccine have been challenged in a series of recent papers. In this work, we intend to contribute to the debate by analyzing the concept of an enhancing vaccine, presenting objections to the epidemiological model base of the concept and, likewise, presenting data that contradict that concept. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. The program success story: a valuable tool for program evaluation.

    Science.gov (United States)

    Lavinghouze, Rene; Price, Ann Webb; Smith, Kisha-Ann

    2007-10-01

    Success stories are evaluation tools that have been used by professionals across disciplines for quite some time. They are also proving to be useful in promoting health programs and their accomplishments. The increasing popularity of success stories is due to the innovative and effective way that they increase a program's visibility, while engaging potential participants, partners, and funders in public health efforts. From the community level to the federal level, program administrators are using success stories as vehicles for celebrating achievements, sharing challenges, and communicating lessons learned. Success stories are an effective means to move beyond the numbers and connect to readers-with a cause they can relate to and want to join. This article defines success stories and provides an overview of several types of story formats, how success stories can be systematically collected, and how they are used to communicate program success.

  17. Functions of personal and vicarious life stories: Identity and empathy

    DEFF Research Database (Denmark)

    Lind, Majse; Thomsen, Dorthe Kirkegaard

    2018-01-01

    The present study investigates functions of personal and vicarious life stories focusing on identity and empathy. Two-hundred-and-forty Danish high school students completed two life story questionnaires: One for their personal life story and one for a close other’s life story. In both...... questionnaires, they identified up to 10 chapters and self-rated the chapters on valence and valence of causal connections. In addition, they completed measures of identity disturbance and empathy. More positive personal life stories were related to lower identity disturbance and higher empathy. Vicarious life...... stories showed a similar pattern with respect to identity but surprisingly were unrelated to empathy. In addition, we found positive correlations between personal and vicarious life stories for number of chapters, chapter valence, and valence of causal connections. The study indicates that both personal...

  18. Vaccine decision-making begins in pregnancy: Correlation between vaccine concerns, intentions and maternal vaccination with subsequent childhood vaccine uptake.

    Science.gov (United States)

    Danchin, M H; Costa-Pinto, J; Attwell, K; Willaby, H; Wiley, K; Hoq, M; Leask, J; Perrett, K P; O'Keefe, Jacinta; Giles, M L; Marshall, H

    2017-08-12

    Maternal and childhood vaccine decision-making begins prenatally. Amongst pregnant Australian women we aimed to ascertain vaccine information received, maternal immunisation uptake and attitudes and concerns regarding childhood vaccination. We also aimed to determine any correlation between a) intentions and concerns regarding childhood vaccination, (b) concerns about pregnancy vaccination, (c) socioeconomic status (SES) and (d) uptake of influenza and pertussis vaccines during pregnancy and routine vaccines during childhood. Women attending public antenatal clinics were recruited in three Australian states. Surveys were completed on iPads. Follow-up phone surveys were done three to six months post delivery, and infant vaccination status obtained via the Australian Childhood Immunisation Register (ACIR). Between October 2015 and March 2016, 975 (82%) of 1184 mothers consented and 406 (42%) agreed to a follow up survey, post delivery. First-time mothers (445; 49%) had significantly more vaccine concerns in pregnancy and only 73% had made a decision about childhood vaccination compared to 89% of mothers with existing children (p-valuepost delivery survey, 46% and 82% of mothers reported receiving pregnancy influenza and pertussis vaccines respectively. The mother's degree of vaccine hesitancy and two attitudinal factors were correlated with vaccine uptake post delivery. There was no association between reported maternal vaccine uptake or SES and childhood vaccine uptake. First time mothers are more vaccine hesitant and undecided about childhood vaccination, and only two thirds of all mothers believed they received enough information during pregnancy. New interventions to improve both education and communication on childhood and maternal vaccines, delivered by midwives and obstetricians in the Australian public hospital system, may reduce vaccine hesitancy for all mothers in pregnancy and post delivery, particularly first-time mothers. Copyright © 2017 Elsevier Ltd

  19. Human Papillomavirus (HPV) Vaccines

    Science.gov (United States)

    ... factors for developing them, such as taking oral contraceptives . A safety review of Gardasil in Denmark and ... and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark ...

  20. [Development of new vaccines].

    Science.gov (United States)

    González-Romo, Fernando; Picazo, Juan J

    2015-10-01

    Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and nanotechnology, among others, have led to new approaches in the development of vaccines. The better identification of ideal epitopes, the strengthening of the immune response due to new adjuvants, and the search of new routes of vaccine administration, are good examples of advances that are already a reality and that will favour the development of more vaccines, their use in indicated population groups, or its production at a lower cost. There are currently more than 130 vaccines are under development against the more wished (malaria or HIV), difficult to get (CMV or RSV), severe re-emerging (Dengue or Ebola), increasing importance (Chagas disease or Leishmania), and nosocomial emerging (Clostridium difficile or Staphylococcus aureus) infectious diseases. Copyright © 2015. Published by Elsevier España, S.L.U.

  1. Ingredients of Vaccines

    Science.gov (United States)

    ... containing preservative that is added to vials of vaccine that contain more than one dose to prevent contamination and growth of potentially harmful bacteria. For children with a prior history of allergic reactions to any of these substances ...

  2. Personal stories of growing up sexually.

    Science.gov (United States)

    Beausang, C C

    2000-01-01

    Prevention of problems related to sexuality during adolescence continues to be a major public health challenge. Describing childhood perceptions of sexuality is an important step in understanding sexual issues during adolescence. However, there is a paucity of information about sexuality in early life. Therefore, the purpose of this study was to describe recurrent themes in personal stories of growing up sexually. A thematic analysis with a narrative perspective was applied using the method described by Miles and Huberman (1994). Four interrelated themes pervaded the stories: parents as teachers, sex is secret, learning by experience, and first intercourse as a turning point. These findings have major implications for sexual health education and counseling in addition to further research.

  3. Salvage Stories, Preserving Narratives, and Museum Ships

    Directory of Open Access Journals (Sweden)

    Andrew Sawyer

    2013-11-01

    Full Text Available Preserved ships and other vessels are associated with a historiography, in Europe at least, which is still marked by parochialism, antiquarianism, and celebratory narrative. Many evidence difficult histories, and they are also extremely expensive to preserve. Yet, they are clearly valued, as nations in Europe invest heavily in them. This survey examines a range of European examples as sites of cultural, political and national identity. An analytical framework foregrounding the role of narrative and story reveals three aspects to these exhibits: explicit stories connected with specific nations, often reinforcing broader, sometimes implicit, national narratives; and a teleological sequence of loss, recovery and preservation, influenced by nationality, but very similar in form across Europe

  4. Current status of rotavirus vaccines.

    Science.gov (United States)

    Wang, Ching-Min; Chen, Shou-Chien; Chen, Kow-Tong

    2015-11-01

    Rotaviruses remain the major cause of childhood diarrheal disease worldwide and of diarrheal deaths of infants and children in developing countries. The huge burden of childhood rotavirus-related diarrhea in the world continues to drive the remarkable pace of vaccine development. Research articles were searched using terms "rotavirus" and "rotavirus vaccine" in MEDLINE and PubMed. Articles not published in the English language, articles without abstracts, and opinion articles were excluded from the review. After preliminary screening, all articles were reviewed and synthesized to provide an overview of current vaccines and vaccination programs. In this review of the global rotavirus vaccines and vaccination programs, the principles of rotavirus vaccine development and the efficacy of the currently licensed vaccines from both developed and developing countries were summarized. Rotavirus is a common cause of diarrhea in children in both developed and developing countries. Rotavirus vaccination is a cost-effective measure to prevent rotavirus diarrhea.

  5. Vaccines for Older Adults.

    Science.gov (United States)

    Worz, Chad; Martin, Caren McHenry; Travis, Catherine

    2017-09-01

    Several vaccine-preventable diseases-influenza, pneumonia, herpes zoster, and pertussis-threaten the health of older adults in the United States. Both the costs associated with treating these diseases and the potential to increase morbidity and mortality are high for this patient population. Pharmacists and other health care professionals play a significant role in ensuring the elderly patient receives the recommended vaccines at the recommended intervals.

  6. Beninese vaccination clinic

    OpenAIRE

    Linda Sun

    2017-01-01

    This photo was taken in the village of Ladji, which is on the outskirts of Cotonou, the capital of Benin. At the time, I was a second year medical student volunteering at a local medical clinic. On every Wednesday morning, many Beninese babies, like this one, cry out of discomfort while receiving their monthly vaccinations. The photo shows a local clinic nurse administering the vaccination.

  7. Beninese vaccination clinic

    Directory of Open Access Journals (Sweden)

    Linda Sun

    2017-04-01

    Full Text Available This photo was taken in the village of Ladji, which is on the outskirts of Cotonou, the capital of Benin. At the time, I was a second year medical student volunteering at a local medical clinic. On every Wednesday morning, many Beninese babies, like this one, cry out of discomfort while receiving their monthly vaccinations. The photo shows a local clinic nurse administering the vaccination.

  8. HPV vaccines: a controversial issue?

    Science.gov (United States)

    Nicol, A F; Andrade, C V; Russomano, F B; Rodrigues, L L S; Oliveira, N S; Provance, D W

    2016-01-01

    Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits.

  9. Epilepsy and vaccinations: Italian guidelines.

    Science.gov (United States)

    Pruna, Dario; Balestri, Paolo; Zamponi, Nelia; Grosso, Salvatore; Gobbi, Giuseppe; Romeo, Antonino; Franzoni, Emilio; Osti, Maria; Capovilla, Giuseppe; Longhi, Riccardo; Verrotti, Alberto

    2013-10-01

    Reports of childhood epilepsies in temporal association with vaccination have had a great impact on the acceptance of vaccination programs by health care providers, but little is known about this possible temporal association and about the types of seizures following vaccinations. For these reasons the Italian League Against Epilepsy (LICE), in collaboration with other Italian scientific societies, has decided to generate Guidelines on Vaccinations and Epilepsy. The aim of Guidelines on Vaccinations and Epilepsy is to present recent unequivocal evidence from published reports on the possible relationship between vaccines and epilepsy in order to provide information about contraindications and risks of vaccinations in patients with epilepsy. The following main issues have been addressed: (1) whether contraindications to vaccinations exist in patients with febrile convulsions, epilepsy, and/or epileptic encephalopathies; and (2) whether any vaccinations can cause febrile seizures, epilepsy, and/or epileptic encephalopathies. Diphtheria-tetanus-pertussis (DTP) vaccination and measles, mumps, and rubella vaccination (MMR) increase significantly the risk of febrile seizures. Recent observations and data about the relationships between vaccination and epileptic encephalopathy show that some cases of apparent vaccine-induced encephalopathy could in fact be caused by an inherent genetic defect with no causal relationship with vaccination. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

  10. HPV vaccines: a controversial issue?

    Directory of Open Access Journals (Sweden)

    A.F. Nicol

    2016-01-01

    Full Text Available Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits.

  11. Member State Event: Telling CERN's story !

    CERN Multimedia

    2004-01-01

    As part of the events to mark the Laboratory's fiftieth anniversary, members of the CERN personnel are telling the story of CERN. Robert Cailliau (on the right), currently responsible for CERN's external communications, and Chiara Mariotti (in the center), a physicist working at CMS, were invited to talk about the history of CERN and the Web at a conference in the 'Science Thursdays' series entitled 'From the Quark to the Web' in Turin on 26 February.

  12. Story Blocks : Reimagining narrative through the blockchain

    OpenAIRE

    Maxwell, Deborah; Speed, Chris; Pschetz, Larissa

    2017-01-01

    Digital technology is changing, and has changed the ways we create and consume narratives, from moving images and immersive storyworlds to digital longform and multi-branched story experiences. At the same time, blockchain, the technology that underpins cryptocurrencies such as Bitcoin, is revolutionising the way that transactions and exchanges occur. As a globally stored and collaboratively written list of all transactions that have ever taken place within a given system, the blockchain dece...

  13. Key Facts about Seasonal Flu Vaccine

    Science.gov (United States)

    ... Swine Variant Pandemic Other Key Facts About Seasonal Flu Vaccine Language: English (US) Español Recommend on Facebook ... the flu is to get vaccinated each year. Flu Vaccination Why should people get vaccinated against the ...

  14. Meningococcal group B vaccines.

    Science.gov (United States)

    Findlow, Jamie

    2013-06-01

    Meningococcal disease remains a devastating and feared infection with a significant morbidity and mortality profile. The successful impact of meningococcal capsular group C glyconconjugate vaccines introduced into the UK infant immunization schedule in 1999, has resulted in >80% of disease now being attributable to meningococcal capsular group B (MenB). MenB glyconconjugate vaccines are not immunogenic and hence, vaccine design has focused on sub-capsular antigens. Recently, a four component vaccine to combat MenB disease (4CMenB) has progressed through clinical development and was approved by the European Medicines Agency at the end of 2012. This vaccine has proven safe and immunogenic and has been predicted to provide protection against ~73% of the MenB disease from England and Wales. Recommendation/implementation of the vaccine into the UK infant schedule is currently being evaluated. 4CMenB has the potential to provide protection against a significant proportion of MenB disease in the UK which is currently unpreventable.

  15. Genome-derived vaccines.

    Science.gov (United States)

    De Groot, Anne S; Rappuoli, Rino

    2004-02-01

    Vaccine research entered a new era when the complete genome of a pathogenic bacterium was published in 1995. Since then, more than 97 bacterial pathogens have been sequenced and at least 110 additional projects are now in progress. Genome sequencing has also dramatically accelerated: high-throughput facilities can draft the sequence of an entire microbe (two to four megabases) in 1 to 2 days. Vaccine developers are using microarrays, immunoinformatics, proteomics and high-throughput immunology assays to reduce the truly unmanageable volume of information available in genome databases to a manageable size. Vaccines composed by novel antigens discovered from genome mining are already in clinical trials. Within 5 years we can expect to see a novel class of vaccines composed by genome-predicted, assembled and engineered T- and Bcell epitopes. This article addresses the convergence of three forces--microbial genome sequencing, computational immunology and new vaccine technologies--that are shifting genome mining for vaccines onto the forefront of immunology research.

  16. SAGA: A DSL for Story Management

    Directory of Open Access Journals (Sweden)

    Lucas Beyak

    2011-09-01

    Full Text Available Video game development is currently a very labour-intensive endeavour. Furthermore it involves multi-disciplinary teams of artistic content creators and programmers, whose typical working patterns are not easily meshed. SAGA is our first effort at augmenting the productivity of such teams. Already convinced of the benefits of DSLs, we set out to analyze the domains present in games in order to find out which would be most amenable to the DSL approach. Based on previous work, we thus sought those sub-parts that already had a partially established vocabulary and at the same time could be well modeled using classical computer science structures. We settled on the 'story' aspect of video games as the best candidate domain, which can be modeled using state transition systems. As we are working with a specific company as the ultimate customer for this work, an additional requirement was that our DSL should produce code that can be used within a pre-existing framework. We developed a full system (SAGA comprised of a parser for a human-friendly language for 'story events', an internal representation of design patterns for implementing object-oriented state-transitions systems, an instantiator for these patterns for a specific 'story', and three renderers (for C++, C# and Java for the instantiated abstract code.

  17. Story Telling With Storyboards: Enhancements and Experiences

    Science.gov (United States)

    King, T. A.; Grayzeck, E. J.; Galica, C.; Erickson, K. J.

    2016-12-01

    A year ago a tool to help tell stories, called the Planetary Data Storyboard, was introduced. This tool is designed to use today's technologies to tell stories that are rich multi-media experiences, blending text, animations, movies and infographics. The Storyboard tool presents a set of panels that contain representative images of an event with associated notes or instructions. The panels are arranged in a timeline that allow a user to experience a discovery or event in the same way it occurred. Each panel can link to a more detailed source such as a publication, the data that was collected or items derived from the research (like movies or animations). A storyboard can be used to make science discovery more accessible to people by presenting events in an easy to follow layout. A storyboard can also help to teach the scientific method, by following the experiences of a researcher as they investigate a phenomenon or try to understand a new set of observations. We present the new features of Storyboard tool and show example stories for scientific discoveries.

  18. How influenza vaccination policy may affect vaccine logistics.

    Science.gov (United States)

    Assi, Tina-Marie; Rookkapan, Korngamon; Rajgopal, Jayant; Sornsrivichai, Vorasith; Brown, Shawn T; Welling, Joel S; Norman, Bryan A; Connor, Diana L; Chen, Sheng-I; Slayton, Rachel B; Laosiritaworn, Yongjua; Wateska, Angela R; Wisniewski, Stephen R; Lee, Bruce Y

    2012-06-22

    When policymakers make decision about the target populations and timing of influenza vaccination, they may not consider the impact on the vaccine supply chains, which may in turn affect vaccine availability. Our goal is to explore the effects on the Thailand vaccine supply chain of introducing influenza vaccines and varying the target populations and immunization time-frames. We Utilized our custom-designed software HERMES (Highly Extensible Resource for Modeling Supply Chains), we developed a detailed, computational discrete-event simulation model of the Thailand's National Immunization Program (NIP) supply chain in Trang Province, Thailand. A suite of experiments simulated introducing influenza vaccines for different target populations and over different time-frames prior to and during the annual influenza season. Introducing influenza vaccines creates bottlenecks that reduce the availability of both influenza vaccines as well as the other NIP vaccines, with provincial to district transport capacity being the primary constraint. Even covering only 25% of the Advisory Committee on Immunization Practice-recommended population while administering the vaccine over six months hinders overall vaccine availability so that only 62% of arriving patients can receive vaccines. Increasing the target population from 25% to 100% progressively worsens these bottlenecks, while increasing influenza vaccination time-frame from 1 to 6 months decreases these bottlenecks. Since the choice of target populations for influenza vaccination and the time-frame to deliver this vaccine can substantially affect the flow of all vaccines, policy-makers may want to consider supply chain effects when choosing target populations for a vaccine. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Making up History: False Memories of Fake News Stories

    Directory of Open Access Journals (Sweden)

    Danielle C. Polage

    2012-05-01

    Full Text Available Previous research has shown that information that is repeated is more likely to be rated as true than information that has not been heard before. The current experiment examines whether familiarity with false news stories would increase rates of truthfulness and plausibility for these events. Further, the experiment tested whether false stories that were familiar would result in the creation of a false memory of having heard the story outside of the experiment. Participants were exposed to false new stories, each portrayed by the investigator as true news stories. After a five week delay, participants who had read the false experimental stories rated them as more truthful and more plausible than participants who had not been exposed to the stories. In addition, there was evidence of the creation of false memories for the source of the news story. Participants who had previously read about the stories were more likely to believe that they had heard the false stories from a source outside the experiment. These results suggest that repeating false claims will not only increase their believability but may also result in source monitoring errors.

  20. Glycoconjugate Vaccines: The Regulatory Framework.

    Science.gov (United States)

    Jones, Christopher

    2015-01-01

    Most vaccines, including the currently available glycoconjugate vaccines, are administered to healthy infants, to prevent future disease. The safety of a prospective vaccine is a key prerequisite for approval. Undesired side effects would not only have the potential to damage the individual infant but also lead to a loss of confidence in the respective vaccine-or vaccines in general-on a population level. Thus, regulatory requirements, particularly with regard to safety, are extremely rigorous. This chapter highlights regulatory aspects on carbohydrate-based vaccines with an emphasis on analytical approaches to ensure the consistent quality of successive manufacturing lots.

  1. Wingless Flight: The Lifting Body Story

    Science.gov (United States)

    Reed, R. Dale; Lister, Darlene (Editor); Huntley, J. D. (Editor)

    1997-01-01

    Wingless Flight tells the story of the most unusual flying machines ever flown, the lifting bodies. It is my story about my friends and colleagues who committed a significant part of their lives in the 1960s and 1970s to prove that the concept was a viable one for use in spacecraft of the future. This story, filled with drama and adventure, is about the twelve-year period from 1963 to 1975 in which eight different lifting-body configurations flew. It is appropriate for me to write the story, since I was the engineer who first presented the idea of flight-testing the concept to others at the NASA Flight Research Center. Over those twelve years, I experienced the story as it unfolded day by day at that remote NASA facility northeast of los Angeles in the bleak Mojave Desert. Benefits from this effort immediately influenced the design and operational concepts of the winged NASA Shuttle Orbiter. However, the full benefits would not be realized until the 1990s when new spacecraft such as the X-33 and X-38 would fully employ the lifting-body concept. A lifting body is basically a wingless vehicle that flies due to the lift generated by the shape of its fuselage. Although both a lifting reentry vehicle and a ballistic capsule had been considered as options during the early stages of NASA's space program, NASA initially opted to go with the capsule. A number of individuals were not content to close the book on the lifting-body concept. Researchers including Alfred Eggers at the NASA Ames Research Center conducted early wind-tunnel experiments, finding that half of a rounded nose-cone shape that was flat on top and rounded on the bottom could generate a lift-to-drag ratio of about 1.5 to 1. Eggers' preliminary design sketch later resembled the basic M2 lifting-body design. At the NASA Langley Research Center, other researchers toyed with their own lifting-body shapes. Meanwhile, some of us aircraft-oriented researchers at the, NASA Flight Research Center at Edwards Air

  2. Developing teachers, developing as a teacher: A story about a story

    Directory of Open Access Journals (Sweden)

    Kate Bennie

    2005-10-01

    Full Text Available In this paper I reflect on my changing roles as a mathematics educator, that is, as a teacher educator and as a classroom teacher in a secondary school. This is a personal account of the challenge of translating my beliefs about mathematics teaching and learning into everyday classroom practice. The presentation I use is based on the work of Rowland − the account is presented in the form of personal reflections on a story written about playing the two different roles of teacher educator and classroom teacher. I use the process of writing to try to make sense of my experiences and to explore the use of story as a research methodology. Although the story is intensely personal, there are identifiable themes that run through the narrative, which I suggest may resonate with the experience of other mathematics educators.

  3. Success Stories | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NIH’s world-class facilities, resources, and discoveries. Some of our partnerships have resulted in the commercialization of therapeutics, vaccines, diagnostics, medical devices and research tools that benefit patients worldwide. TTC is proud to share a few examples of our successful partnerships. | [google6f4cd5334ac394ab.html

  4. Vaccination Perceptions of College Students: With and without Vaccination Waiver

    Directory of Open Access Journals (Sweden)

    Emmanuel D. Jadhav

    2018-02-01

    Full Text Available IntroductionThe resurgence of vaccine preventable diseases occurs more often among intentionally unvaccinated individuals, placing at direct risk young adults not caught up on vaccinations. The objectives of this study were to characterize the sociodemographic characteristics of young adults with and without vaccination waivers and identify their perceived benefits, barriers, and influencers of vaccination.MethodsYoung adults (n = 964 from a Midwestern rural university responded to a survey (fall 2015—spring 2016 designed to identify their perception toward vaccination. Instrument consistency was measured using the Cronbach α-scores. The Chi-square test was used to test any sociodemographic differences and Mann–Whitney U-tests results for differences between exempt and non-exempt students. Analysis occurred in spring 2017.ResultsA little over one-third of young adults with a vaccination waiver were not up to date on their vaccinations, and think that vaccinations can cause autism. The biggest identifiable benefit was effective control against disease. The surveyed young adults ranked the out of pocket cost associated with vaccination as the most important barrier and safe and easy to use vaccines as the most important influencer of vaccination.ConclusionYoung adults who have had a vaccination waiver appear to not be up to date on their vaccinations. Vaccine administration programs, such as university campus clinics, would benefit from addressing perceptions unique to young adults with and without a vaccine waiver. This would subsequently better provide young adults a second shot for getting appropriately caught up on vaccinations.

  5. Vaccines, adjuvants and autoimmunity.

    Science.gov (United States)

    Guimarães, Luísa Eça; Baker, Britain; Perricone, Carlo; Shoenfeld, Yehuda

    2015-10-01

    Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Stories from Haiti: a comparison of three approaches.

    Science.gov (United States)

    Baumann, Steven L; Bellefleur, Carmelle

    2014-04-01

    Two stories from Haiti are considered from three different perspectives. The first story is about a boy named Joseph Alvyns, whose mother died from cholera in 2011. His story is told in a short film titled Baseball in the time of Cholera. The second story is about Mme. Yolande Marie Nazaire, who was the Director of the Haiti National School of Nursing in Port-au-Prince on the morning of January 12, 2010, when an earthquake killed 90 students and faculty. The three perspectives discussed here are: (a) Critical Reflective in health professional education as used by the University of California at San Francisco (UCSF) School of Medicine; (b) The Capacities of Stories, which is part of a socio-narratology methodology; and(c) Story Theory with implications for global health nursing.

  7. [Walter Matthias Diggelmann--the healing effect of story telling].

    Science.gov (United States)

    Schmid, H J

    2001-06-21

    "Stories are weapons against disease" wrote Swiss writer WM Diggelmann (1927-1979). In writing stories he hoped to counteract the lethal course of his cancer. In the past it had helped him to overcome destitution and social disgrace and had given him identity. His last story Walking on the Island of St. Margaret is a ritual which conjures up an intact future by celebrating the past. Stories try to explain the world. They inform or clarify emotions. In telling stories, doctors and nurses demonstrate sympathy and understanding. Perhaps even greater benefits might be derived from patients telling their own stories. In doing so they emerge as individuals and give their lives purpose. Language is more than communication: it is shelter, link, home, ritual. Storytelling helps patients cope with their diseases. It is not clear whether this or any technique of psychotherapy has any effect upon the course of cancer.

  8. Community vaccine perceptions and its role on vaccination uptake ...

    African Journals Online (AJOL)

    Introduction: Underutilization of vaccines still remains a challenge in many regions across the world. Ileje district is one of the districts in Tanzania with consistently low pentavalent vaccine uptake (69%) and with drop out of 15%. We determined the vaccination completion with regard to Oral Polio virus, Measles, Bacillus ...

  9. Evaluation of vaccine competition using HVT vector vaccines

    Science.gov (United States)

    Turkey herpesvirus (HVT) has been widely used as a vaccine for Marek’s disease (MD) since the 1970s. Because HVT is a safe vaccine that is poorly sensitive to interference from maternally derived antibodies, it has seen rising use as a vector for vaccines developed for protection against other comm...

  10. Flu Vaccine Safety and Pregnancy

    Science.gov (United States)

    ... Influenza Types Seasonal Avian Swine Variant Pandemic Other Flu Vaccine Safety and Pregnancy Questions & Answers Language: English ( ... flu vaccine? Why should pregnant women get a flu shot? Flu is more likely to cause severe ...

  11. New Vaccines Help Protect You

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues New Vaccines Help Protect You Past Issues / Fall 2006 Table of ... with a few deaths. Therefore, this vaccine will help reduce one of our most common and potentially ...

  12. Macromolecular systems for vaccine delivery.

    Science.gov (United States)

    MuŽíková, G; Laga, R

    2016-10-20

    Vaccines have helped considerably in eliminating some life-threatening infectious diseases in past two hundred years. Recently, human medicine has focused on vaccination against some of the world's most common infectious diseases (AIDS, malaria, tuberculosis, etc.), and vaccination is also gaining popularity in the treatment of cancer or autoimmune diseases. The major limitation of current vaccines lies in their poor ability to generate a sufficient level of protective antibodies and T cell responses against diseases such as HIV, malaria, tuberculosis and cancers. Among the promising vaccination systems that could improve the potency of weakly immunogenic vaccines belong macromolecular carriers (water soluble polymers, polymer particels, micelles, gels etc.) conjugated with antigens and immunistumulatory molecules. The size, architecture, and the composition of the high molecular-weight carrier can significantly improve the vaccine efficiency. This review includes the most recently developed (bio)polymer-based vaccines reported in the literature.

  13. Liver Disease and Adult Vaccination

    Science.gov (United States)

    ... The Basics Adult Vaccination Resources for Healthcare Professionals Liver Disease and Adult Vaccination Recommend on Facebook Tweet ... critical for people with health conditions such as liver disease. If you have chronic liver disease, talk ...

  14. HPV Vaccine - Questions and Answers

    Science.gov (United States)

    ... United States currently has the safest, most effective vaccine supply in history. Years of testing are required by law to ensure the safety of vaccines before they are made available for use in ...

  15. Unrealistic Hope and Unnecessary Fear: Exploring How Sensationalistic News Stories Influence Health Behavior Motivation.

    Science.gov (United States)

    Nabi, Robin L; Prestin, Abby

    2016-09-01

    In light of the inherent conflict between the nature of science (slow, subject to correction) and the nature of news (immediate, dramatic, novel), this study examines the effect of emotional health news coverage on intentions to engage in protective health behaviors. One hundred seventy-seven students read news stories designed to evoke either fear or hope about human papillomavirus (HPV) followed by different levels of response efficacy information regarding an impending HPV vaccine. Results indicated no main effects for emotion frame or response efficacy, but a significant interaction suggested that emotionally-consistent presentations (fear/low efficacy; hope/high efficacy) boosted intentions to engage in protective actions relative to emotionally-inconsistent, sensationalized presentations (fear/high efficacy, hope/low efficacy). Consistent with the emotion-as-frame perspective, this effect was moderated by perceived knowledge about HPV prevention. Effects of the sensationalized story constructions on trust in health news were also evidenced. Implications for the role of emotional health news coverage in priming prior knowledge about preventative health behaviors, along with future research directions, are discussed.

  16. HIV-1 vaccines

    Science.gov (United States)

    Excler, Jean-Louis; Robb, Merlin L; Kim, Jerome H

    2014-01-01

    The development of a safe and effective preventive HIV-1 vaccine remains a public health priority. Despite scientific difficulties and disappointing results, HIV-1 vaccine clinical development has, for the first time, established proof-of-concept efficacy against HIV-1 acquisition and identified vaccine-associated immune correlates of risk. The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk. The development of vaccine strategies such as improved envelope proteins formulated with potent adjuvants and DNA and vectors expressing mosaics, or conserved sequences, capable of eliciting greater breadth and depth of potentially relevant immune responses including neutralizing and non-neutralizing antibodies, CD4+ and CD8+ cell-mediated immune responses, mucosal immune responses, and immunological memory, is now proceeding quickly. Additional human efficacy trials combined with other prevention modalities along with sustained funding and international collaboration remain key to bring an HIV-1 vaccine to licensure. PMID:24637946

  17. [Vaccination against rubella].

    Science.gov (United States)

    Rossolini, A; Barberi, A

    1984-01-01

    The infection caused by the rubella virus is a mild disease usually with no or rare complications in children and adults. On the contrary, intrauterine fetal infection may result in defects of the child, which may either be present at birth or become apparent later in life. Such a risk led to the preparation and use of active immunoprophylaxis against rubella in females of child-bearing age, in order to prevent congenital rubella. Three rubella viruses are employed to prepare the vaccine, all derived from the same viral strain. Doubts however, exist about vaccination, in particular about (1) its teratogenic potential in pregnancy; (2) the duration of protection. As a matter of fact, congenital malformations in the fetus exposed to vaccine virus through the mother have been reported in 3% of cases. As to the second point, the data on the protective immunity in time of the vaccine are very controversial. It is clear, anyhow, that protection against infection is associated not only with persistence of adequate serum levels of antibody, but also with other immunological parameters which are still unknown. These considerations, together with the observation that a relative high percentage of vaccine recipients do not respond, lead us to suggest modifications in the present scheduling of immunization against rubella.

  18. Economics of vaccines revisited.

    Science.gov (United States)

    Postma, Maarten J; Standaert, Baudouin A

    2013-05-01

    Performing a total health economic analysis of a vaccine newly introduced into the market today is a challenge when using the conventional cost-effectiveness analysis we normally apply on pharmaceutical products. There are many reasons for that, such as: the uncertainty in the total benefit (direct and indirect) to be measured in a population when using a cohort model; (1) appropriate rules about discounting the long-term impact of vaccines are absent jeopardizing therefore their value at the initial investment; (2) the presence of opposite contexts when introducing the vaccine in developed vs. the developing world with high benefits, low initial health care investment for the latter vs. marginal benefit and high cost for the former; with a corresponding paradox for the vaccine becoming very cost-effective in low income countries but rather medium in middle low to high middle income countries; (3) and the type of trial assessment for the newer vaccines is now often performed with immunogenicity reaction instead of clinical endpoints which still leaves questions on their real impact and their head-to-head comparison. (4.)

  19. Vaccines for the elderly.

    Science.gov (United States)

    Del Giudice, Giuseppe; Weinberger, Birgit; Grubeck-Loebenstein, Beatrix

    2015-01-01

    The aging of the human population is posing serious challenges to research and to public health authorities in order to prevent diseases that more frequently affect the elderly, a portion of the population that will increase more and more in the coming years. While some vaccines exist and are used in the elderly to effectively fight against some infections (e.g. influenza, pneumococci, varicella-zoster virus, diphtheria, and tetanus), still a lot of work remains to be done to better adapt these vaccines and to develop new ones for this age group. The prevention of infectious diseases affecting the elderly can be successful only through a holistic approach. This approach will aim at the following: (1) a deeper understanding of the mechanisms leading to the senescence of the immune system, (2) a better and broader use of vaccines recommended for the elderly, (3) the use of vaccines currently considered only for other age groups and (4) actively priming the population when they are immunological competent, before the physiological waning of immune responsiveness may affect the beneficial effects of vaccination. © 2014 S. Karger AG, Basel

  20. Vaccination against tuberculosis.

    Science.gov (United States)

    Martin, Carlos; Aguilo, Nacho; Gonzalo-Asensio, Jesús

    2018-04-04

    BCG (Bacille Calmette-Guérin) vaccination is included in the immunization schedule for tuberculosis endemic countries with a global coverage at birth close to 90% worldwide. BCG was attenuated from Mycobacterium bovis almost a century ago, and provides a strong protection against disseminated forms of the disease, though very limited against pulmonary forms of tuberculosis, responsible for transmission. Novel prophylactic tuberculosis vaccines are in clinical development either to replace BCG or to improve its protection against respiratory forms of the disease. There are limitations understanding the immunological responses involved and the precise type of long-lived immunity that new vaccines need to induce. MTBVAC is the first and only tuberculosis vaccine candidate based on live-attenuated Mycobacterium tuberculosis in clinical evaluation. MTBVAC clinical development plans to target tuberculosis prevention in newborns, as a BCG replacement strategy, and as secondary objective to be tested in adolescents and adults previous vaccinated with BCG. Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  1. Vaccination against seasonal influenza

    CERN Multimedia

    GS Department

    2010-01-01

    This year, as usual, the Medical Service is helping to promote vaccination against seasonal influenza. Vaccination against seasonal flu is especially recommended for anyone who suffers from chronic pulmonary, cardio-vascular or kidney disease or diabetes, is recovering from a serious illness or major surgery, or is over 65 years of age. The flu virus is transmitted through the air and through contact with contaminated surfaces, so frequent hand-washing with soap and/or an antiseptic hand wash is of great importance. As soon as the first symptoms appear (fever above 38°, shivering, coughing, muscle and/or joint pains, generalised weakness), you are strongly recommended to stay at home to avoid spreading the virus. Anyone working on the CERN site who wishes to be vaccinated against seasonal flu should go to the Infirmary (Building 57, ground floor), with their dose of vaccine. The Medical Service will issue a prescription on the day of the vaccination for the purposes of reimbursement through UNIQA...

  2. Storying stories

    NARCIS (Netherlands)

    Kaptein, A.A.; Lyons, A.C.; Pearson, A.S.; van der Geest, S.; Haan, J.; Meulenberg, F.; Smyth, J.M.

    2012-01-01

    In many countries courses on Literature and Medicine (LitMed) are part of the medical curriculum, to develop and teach knowledge and skills in the area of Medical Humanities. We describe a LitMed course designed to encourage medical students at a university medical center to incorporate the

  3. Life story resources in dementia care: a review.

    Science.gov (United States)

    Kindell, Jacqueline; Burrow, Simon; Wilkinson, Ray; Keady, John David

    2014-01-01

    Life story work has a relatively long tradition in the caring sciences and is recognised as an important component of dementia care and practice. However, to date, there has not been a review of accessible life story resources. The paper aims to discuss these issues. Following a systematic approach to identification and inclusion, 11 life story resources were reviewed to ascertain areas of commonality and divergence between the materials. The authors were able to group the analysis under eight areas and at the end of this process, it was uncertain if life story work is a formal staff intervention or an informal activity that people with dementia and their families could engage in. Resources also varied in terms of whether the life story information was organised in a chronological way, or with topics of interest/discussion or with a combination of both. Life story evaluation and its impact on the life of the person with dementia is in need of development. Across the resources the authors identified four reasons to do life story work which the authors have named as: emotional connections; interactional connections; building new connections and practical care connections. There was limited guidance aimed at helping people with dementia to develop and compile their own life story. This paper provides new insights into the usefulness, future directions and content of life story resources in dementia care. It will be of interest to those in health and social care as well as people living with dementia.

  4. Automated Story Direction and Intelligent Tutoring: Towards a Unifying Architecture

    National Research Council Canada - National Science Library

    Riedl, Mark; Lane, H. Chad; Hill, Randall; Swartout, William

    2006-01-01

    .... Our goal is to build training simulations that cultivate compelling storylines while simultaneously maintaining a pedagogical presence by incorporating both automated story direction and intelligent...

  5. The Measles Vaccination Narrative in Twitter: A Quantitative Analysis.

    Science.gov (United States)

    Radzikowski, Jacek; Stefanidis, Anthony; Jacobsen, Kathryn H; Croitoru, Arie; Crooks, Andrew; Delamater, Paul L

    2016-01-01

    The emergence of social media is providing an alternative avenue for information exchange and opinion formation on health-related issues. Collective discourse in such media leads to the formation of a complex narrative, conveying public views and perceptions. This paper presents a study of Twitter narrative regarding vaccination in the aftermath of the 2015 measles outbreak, both in terms of its cyber and physical characteristics. We aimed to contribute to the analysis of the data, as well as presenting a quantitative interdisciplinary approach to analyze such open-source data in the context of health narratives. We collected 669,136 tweets referring to vaccination from February 1 to March 9, 2015. These tweets were analyzed to identify key terms, connections among such terms, retweet patterns, the structure of the narrative, and connections to the geographical space. The data analysis captures the anatomy of the themes and relations that make up the discussion about vaccination in Twitter. The results highlight the higher impact of stories contributed by news organizations compared to direct tweets by health organizations in communicating health-related information. They also capture the structure of the antivaccination narrative and its terms of reference. Analysis also revealed the relationship between community engagement in Twitter and state policies regarding child vaccination. Residents of Vermont and Oregon, the two states with the highest rates of non-medical exemption from school-entry vaccines nationwide, are leading the social media discussion in terms of participation. The interdisciplinary study of health-related debates in social media across the cyber-physical debate nexus leads to a greater understanding of public concerns, views, and responses to health-related issues. Further coalescing such capabilities shows promise towards advancing health communication, thus supporting the design of more effective strategies that take into account the complex

  6. Stories That Heal: Understanding the Effects of Creating Digital Stories With Pediatric and Adolescent/Young Adult Oncology Patients.

    Science.gov (United States)

    Laing, Catherine M; Moules, Nancy J; Estefan, Andrew; Lang, Mike

    The purpose of this philosophical hermeneutic study was to determine if, and understand how, digital stories might be effective therapeutic tools to use with children and adolescents/young adults (AYA) with cancer, thus helping mitigate suffering. Sixteen participants made digital stories with the help of a research assistant trained in digital storytelling and were interviewed following the completion of their stories. Findings from this research revealed that digital stories were a way to have others understand their experiences of cancer, allowed for further healing from their sometimes traumatic experiences, had unexpected therapeutic effects, and were a way to reconcile past experiences with current life. Digital stories, we conclude, show great promise with the pediatric and AYA oncology community and we believe are a way in which the psychosocial effects of cancer treatment may be addressed. Recommendations for incorporating digital stories into clinical practice and follow-up programs are offered.

  7. A brief history of vaccines & vaccination in India

    Directory of Open Access Journals (Sweden)

    Chandrakant Lahariya

    2014-01-01

    Full Text Available The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace variolation by vaccination, setting up of a few vaccine institutes, cholera vaccine trial and the discovery of plague vaccine. The early twentieth century witnessed the challenges in expansion of smallpox vaccination, typhoid vaccine trial in Indian army personnel, and setting up of vaccine institutes in almost each of the then Indian States. In the post-independence period, the BCG vaccine laboratory and other national institutes were established; a number of private vaccine manufacturers came up, besides the continuation of smallpox eradication effort till the country became smallpox free in 1977. The Expanded Programme of Immunization (EPI (1978 and then Universal Immunization Programme (UIP (1985 were launched in India. The intervening events since UIP till India being declared non-endemic for poliomyelitis in 2012 have been described. Though the preventive efforts from diseases were practiced in India, the reluctance, opposition and a slow acceptance of vaccination have been the characteristic of vaccination history in the country. The operational challenges keep the coverage inequitable in the country. The lessons from the past events have been analysed and interpreted to guide immunization efforts.

  8. A brief history of vaccines & vaccination in India.

    Science.gov (United States)

    Lahariya, Chandrakant

    2014-04-01

    The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace variolation by vaccination, setting up of a few vaccine institutes, cholera vaccine trial and the discovery of plague vaccine. The early twentieth century witnessed the challenges in expansion of smallpox vaccination, typhoid vaccine trial in Indian army personnel, and setting up of vaccine institutes in almost each of the then Indian States. In the post-independence period, the BCG vaccine laboratory and other national institutes were established; a number of private vaccine manufacturers came up, besides the continuation of smallpox eradication effort till the country became smallpox free in 1977. The Expanded Programme of Immunization (EPI) (1978) and then Universal Immunization Programme (UIP) (1985) were launched in India. The intervening events since UIP till India being declared non-endemic for poliomyelitis in 2012 have been described. Though the preventive efforts from diseases were practiced in India, the reluctance, opposition and a slow acceptance of vaccination have been the characteristic of vaccination history in the country. The operational challenges keep the coverage inequitable in the country. The lessons from the past events have been analysed and interpreted to guide immunization efforts.

  9. Bursitis efter vaccination i skulderregionen

    DEFF Research Database (Denmark)

    Bliddal, Henning; Torp-Pedersen, Søren; Falk-Riecke, Birgit

    2017-01-01

    Shoulder pain may develop after vaccination in the deltoid area due to inadvertent injection of the vaccine into the subdeltoid bursa, which may be located close to the skin. As far as we know, such vaccination reactions occur more frequently than officially registered, and doctors may not be awa...

  10. Protein carriers of conjugate vaccines

    Science.gov (United States)

    Pichichero, Michael E

    2013-01-01

    The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of the past to T cell-dependent antigenic vaccines that were much more immunogenic and launched a renaissance in vaccinology. This review discusses the conjugate vaccines for prevention of infections caused by Hemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis. Specifically, the characteristics of the proteins used in the construction of the vaccines including CRM, tetanus toxoid, diphtheria toxoid, Neisseria meningitidis outer membrane complex, and Hemophilus influenzae protein D are discussed. The studies that established differences among and key features of conjugate vaccines including immunologic memory induction, reduction of nasopharyngeal colonization and herd immunity, and antibody avidity and avidity maturation are presented. Studies of dose, schedule, response to boosters, of single protein carriers with single and multiple polysaccharides, of multiple protein carriers with multiple polysaccharides and conjugate vaccines administered concurrently with other vaccines are discussed along with undesirable consequences of conjugate vaccines. The clear benefits of conjugate vaccines in improving the protective responses of the immature immune systems of young infants and the senescent immune systems of the elderly have been made clear and opened the way to development of additional vaccines using this technology for future vaccine products. PMID:23955057

  11. Vaccination recommended for pregnant women

    Directory of Open Access Journals (Sweden)

    Justyna Magdalena Skolarczyk

    2017-04-01

    Full Text Available A vaccine is a formulation of biological origin that contains substances capable of inducing immune processes without the ability to cause a disease. Vaccination is considered the best mean to prevent infectious diseases and their serious complications. Vaccination of a pregnant women can provide protection against severe infectious diseases of both pregnant women and their children. The aim of the study is to present currently available types of vaccines recommended for pregnant women and indications for their use by analyzing the data available in the PubMed, and Medline electronic databases. In the United States, vaccination recommendations for pregnant women include inactivated influenza vaccine and tetanus and diphtheria toxoid vaccine (Tdap. In some countries, pregnant women also receive a vaccine against hepatitis B as well as anti hepatitis A and E. There are also studies on vaccines against the RSV virus and pneumococci. Vaccination is the most effective form of prevention of infectious diseases and their use during pregnancy does not entail any additional risk to the mother or her baby. The benefits of vaccination are huge, so pregnant women should take  recommended vaccination and shouldn’t  be afraid of using them.

  12. Story-Making as Methodology: Disrupting Dominant Stories through Multimedia Storytelling.

    Science.gov (United States)

    Rice, Carla; Mündel, Ingrid

    2018-05-01

    In this essay, we discuss multimedia story-making methodologies developed through Re•Vision: The Centre for Art and Social Justice that investigates the power of the arts, especially story, to positively influence decision makers in diverse sectors. Our story-making methodology brings together majority and minoritized creators to represent previously unattended experiences (e.g., around mind-body differences, queer sexuality, urban Indigenous identity, and Inuit cultural voice) with an aim to building understanding and shifting policies/practices that create barriers to social inclusion and justice. We analyze our ongoing efforts to rework our storytelling methodology, spotlighting acts of revising carried out by facilitators and researchers as they/we redefine methodological terms for each storytelling context, by researcher-storytellers as they/we rework material from our lives, and by receivers of the stories as we revise our assumptions about particular embodied histories and how they are defined within dominant cultural narratives and institutional structures. This methodology, we argue, contributes to the existing qualitative lexicon by providing innovative new approaches not only for chronicling marginalized/misrepresented experiences and critically researching selves, but also for scaffolding intersectional alliances and for imagining more just futures. © 2018 Canadian Sociological Association/La Société canadienne de sociologie.

  13. No stories without angles: Exploring the origin of cultural frames by reconstructing news stories

    NARCIS (Netherlands)

    Boesman, J.L.J.; d'Haenens, L.; Van Gorp, B.

    2014-01-01

    his paper investigates the framing practices of Flemish newspaper journalists, focusing on the production side of framing. In the selection and construction of events into news stories, the use of frames is seen as an inevitable journalistic practice to translate those events to the audience. This

  14. Early life vaccination

    DEFF Research Database (Denmark)

    Nazerai, Loulieta; Bassi, Maria Rosaria; Uddbäck, Ida Elin Maria

    2016-01-01

    Intracellular pathogens represent a serious threat during early life. Importantly, even though the immune system of newborns may be characterized as developmentally immature, with a propensity to develop Th2 immunity, significant CD8+ T-cell responses may still be elicited in the context of optimal...... the first period of life and provide a pertinent alternative in infant vaccinology. To address this, infant mice were vaccinated with three different adenoviral vectors and the CD8+ T-cell response after early life vaccination was explored. We assessed the frequency, polyfunctionality and in vivo...... cytotoxicity of the elicited memory CD8+ T cells, as well as the potential of these cells to respond to secondary infections and confer protection. We further tested the impact of maternal immunity against our replication-deficient adenoviral vector during early life vaccination. Overall, our results indicate...

  15. Vaccination against seasonal influenza

    CERN Multimedia

    DG Unit

    2009-01-01

    As every year, the Medical Service is taking part in the campaign to promote vaccination against seasonal influenza. Vaccination against seasonal influenza is especially recommended for people suffering from chronic lung, cardio-vascular or kidney conditions or diabetes, for those recovering from a serious illness or surgical operation and for everyone over the age of 65. The influenza virus is transmitted by air and contact with contaminated surfaces, hence the importance of washing hands regularly with soap and / or disinfection using a hydro-alcoholic solution. From the onset of symptoms (fever> 38°, chills, cough, muscle aches and / or joint pain, fatigue) you are strongly recommended to stay at home to avoid spreading the virus. In the present context of the influenza A (H1N1) pandemic, it is important to dissociate these two illnesses and emphasise that the two viruses and the vaccines used to combat them are quite different and that protection against one will not pr...

  16. Story telling engine based on agent interaction

    OpenAIRE

    Porcel, Juan Carlos

    2008-01-01

    Comics have been used as a programming tool for agents, giving them instructions on how to act. In this thesis I do this in reverse, I use comics to describe the actions of agents already interacting with each other to create a storytelling engine that dynamically generate stories, based on the interaction of said agents. The model for the agent behaviours is based on the improvisational puppets model of Barbara Hayes-Roth. This model is chosen due to the nature of comics themselves. Comics ...

  17. Energy efficiency in multi-story buildings

    Directory of Open Access Journals (Sweden)

    Staritcyna Anastasiia

    2016-01-01

    Full Text Available In this project a research on energy efficiency of Malta house was provided, it is a residential multi-story building in Helsinki, Jätkäsaari area. This project describes introduction with a new heating system for residential dwellings, which uses only heated air. To maintain air temperature in comfort level heat recovery and district heating is used in the same system. The task was to research efficacy of the enclosure structures. For research the 3D model has been created in the program the Revit 2015 and Lumion 13. Thermotechnical calculation for three types of a design has been executed in the program U-value.net.

  18. Journalism Curiosity and Story Telling Frame

    DEFF Research Database (Denmark)

    Grunwald, Ebbe; Rupar, Verica

    2009-01-01

    This comparative study of journalism practices in Australia and Denmark explores the interplay between two concepts relevant for journalism's meaning-making activity: a curiosity seen as an action meant to close an information gap, and a story telling frame seen as a form of structuring information...... the epistemological and organisational dimension of frames relates to the process of  meaning-making. We suggest refining the concept of frame in journalism studies by making a distinction between a frame (an epistemological category) and an angle (a textual organisation category). Our investigation shows...... that this distinction better serves the analysis and understanding of the mechanisms behind journalism in comparative contexts. Udgivelsesdato: December...

  19. The news machine hacking, the untold story

    CERN Document Server

    Hanning, James

    2014-01-01

    There is one mystery figure at the heart of ?Hackergate' ? Glenn Mulcaire, the News of the World's top private investigator. The former AFC Wimbledon footballer has never spoken publicly or in court about his work investigating and backing up front-page news stories (such as the News of the World's award-winning David Beckham scoop). Mulcaire's arrest in 2006 for intercepting royal-household phone messages barely registered at the time. Yet his work has continued to generate headlines and embarrassment for the establishment ? with a Prime Minister on the back foot after his former aide Andy

  20. TEACHING SPEAKING THROUGH THE IMPLEMENTATION OF STORY TELLING TECHNIQUE BY USING STORY-TELLING

    Directory of Open Access Journals (Sweden)

    Purwatiningsih Purwatiningsih

    2015-12-01

    Full Text Available Learning a language especially English is expected to help students to be able to use it as a means of communication. Communicating is understanding and expressing information, thought and feeling, and expanding science, technology and culture. Communicating ability means being able to understand a discourse, namely being able to understand and produce spoken and written texts through the four language skills: listening, speaking, reading and writing this classroom action research was conducted to solve the students’ problems in speaking. It is to improve the students’ ability in speaking through story-telling technique using picture series in terms of content and delivery of the story. The design of this study is classroom action research which was conducted in two cycles consisting of six meetings. The subjects of this study were students of grade x-9 of MAN 2 Madiun in 2012/2013 academic year. The instruments to collect the data were observation checklists, field notes, speaking task measured using scoring rubrics, and questionnaire. The criteria of success were determined on the basis of the students’ participation in the teaching-learning process, the students’ speaking achievement in terms of score (telling a story individually, and the students’ responses to the implementation of story-telling technique using picture series. The finding of the study indicated that the implementation of the technique was successful in improving the students’ speaking ability, since the criteria of success were achieved. The first criterion was if 70% of the students participate or are actively involved in the teaching and learning process, and the data analysis confirmed that 84% of students were actively involved. Concerning the second criterion was if 70% of the students achieve the score greater than or equal to 75, the finding showed that 81% of the students already achieved scores greater than 75. The last criterion, if 70% of students

  1. Meningococcal B vaccine. An immunogenic vaccine possibly useful during outbreaks.

    Science.gov (United States)

    2014-09-01

    Invasive meningococcal infections can be life-threatening and cause severe sequelae. Antibiotic therapy is only partially effective. Bexsero is the first meningococcal B vaccine to be approved in the European Union. It contains four capsular antigens from various strains of group B meningococci. Clinical trials of this meningococcal B vaccine did not assess clinical protection. Two immunogenicity studies in adults, one in adolescents and six in infants, are available. They established the immunogenicity of the meningococcal B vaccine, determined age-appropriate vaccination schedules, and verified that concomitant administration of other vaccines did not undermine its immunogenicity. In the absence of relevant clinical trials, an in vitro study showed that sera from vaccinated individuals were likely to have bactericidal activity against 85% of 200 invasive meningococcal B strains isolated in France in 2007-2008. The meningococcal B vaccine provoked local adverse effects in most vaccinees, including local erythema, induration and pain. Fever occurred in about half of vaccinated children. Six cases of Kawasaki syndrome have been reported in children who received the vaccine, compared to only one case in control groups. In practice, the harm-benefit balance of this meningococcal B vaccine justify using it during outbreaks, provided the outbreak strain is covered by the vaccine antigens. Vaccinees should be enrolled in studies designed to evaluate clinical efficacy and to better determine the risk of Kawasaki syndrome.

  2. Vaccines for Canine Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Faeze Foroughi-Parvar

    2014-01-01

    Full Text Available Leishmania infantum is the obligatory intracellular parasite of mammalian macrophages and causes zoonotic visceral leishmaniasis (ZVL. The presence of infected dogs as the main reservoir host of ZVL is regarded as the most important potential risk for human infection. Thus the prevention of canine visceral leishmaniasis (CVL is essential to stop the current increase of the Mediterranean visceral leishmaniasis. Recently considerable advances in achieving protective immunization of dogs and several important attempts for achieving an effective vaccine against CVL lead to attracting the scientists trust in its important role for eradication of ZVL. This paper highlights the recent advances in vaccination against canine visceral leishmaniasis from 2007 until now.

  3. Using Esri Story Map Technology to Demonstrate SERVIR Global Success Stories

    Science.gov (United States)

    Adams, E. C.; Flores, A.; Muench, R.; Coulter, D.; Limaye, A. S.; Irwin, D.

    2016-12-01

    A joint development initiative of the National Aeronautics and Space Administration (NASA) and the United States Agency for International Development (USAID), SERVIR works in partnership with leading regional organizations world-wide to help developing countries build their capacity to use information provided by Earth observing satellites and geospatial technologies for managing climate and weather risks, food security and agriculture, land use change, water resources, and natural disaster response. The SERVIR network currently includes 4 regional hubs: Eastern and Southern Africa, Hindu-Kush-Himalaya, the Lower Mekong region, and West Africa, and has completed project activities in the Mesoamerica region. SERVIR has activities in over 40 countries, has developed 70 custom tools, and has collaborated with 155 institutions to apply current state of the art science and technology to decision making. Many of these efforts have the potential to continue to influence decision-making at new institutions throughout the globe; however, engaging those stakeholders and society while maintaining a global brand identity is challenging. Esri story map technologies have allowed the SERVIR network to highlight the applications of SERVIR projects. Conventional communication approaches have been used in SERVIR to share success stories of our geospatial projects; however, the power of Esri story telling offers a great opportunity to convey effectively the impacts of the geospatial solutions provided through SERVIR to end users. This paper will present use cases of how Esri story map technologies are being used across the SERVIR network to effectively communicate science to SERVIR users and general public. The easy to use design templates and interactive user interface are ideal for highlighting SERVIR's diverse products. In addition, the SERVIR team hopes to continue using story maps for project outreach and user engagement.

  4. [From new vaccine to new target: revisiting influenza vaccination].

    Science.gov (United States)

    Gérard, M

    2011-09-01

    Annual vaccination is since many years the corner stone of Influenza control strategy. Because conventional vaccine are needle-based, are less immunogenic in old people and induce only systemic IgG production, intranasal and intradermal vaccines that are recently or will be soon available in Belgium will offer distinct advantages. Intradermal vaccination is on the Belgian market since 2010. A stronger immune response that allows an antigen sparing strategy is elicited because antigens are delivered near the dermal dendritic cells. Local side effects are more pronounced than after intramuscular injection. The needle-free intranasal vaccine that has been approved for use in people less than 18 years old by the EMEA in October 2010 induces also a mucosal IgA response. Improved clinical results than with intramuscular vaccine has been documented in several studies in children. Several conditions are contraindication to nasal vaccination because of patterns of side effects and because the vaccine is an live-attenuated vaccine. Pregnant women has become a top priority for Influenza vaccination in the recommendations of the High Council of Health in Belgium since the 2009 H1N1 pandemic. Several studies has since then documented the increased risk for Influenza-related morbidity in pregnant women especially during the third trimester and independently of the presence of other comorbidities. Reduced incidence of documented Influenza and of Influenza-related hospitalizations are observed in the new born of vaccinated women until 6 months of age. Availability of new vaccines for Influenza and better knowledge of the benefit of vaccination in target populations are important tools to optimize vaccine coverage of the population.

  5. Dancing Lights: Creating the Aurora Story

    Science.gov (United States)

    Wood, E. L.; Cobabe-Ammann, E. A.

    2009-12-01

    Science tells a story about our world, our existence, our history, and the larger environment our planet occupies. Bearing this in mind, we created a series of lessons for 3rd-5th grades using a cross-disciplinary approach to teaching about the aurora by incorporating stories, photos, movies, and geography into the science in order to paint a broad picture and answer the question, “why do we care?” The fundamental backbone of the program is literacy. Students write and illustrate fiction and non-fiction work, poetry, and brochures that solidify both language arts skills and science content. In a time when elementary teachers relegate science to less than one hour per week, we have developed a novel science program that can be easily integrated with other topics during the typical school day to increase the amount of science taught in a school year. We are inspiring students to take an interest in the natural world with this program, a stepping-stone for larger things.

  6. Noninvasive vaccination against infectious diseases.

    Science.gov (United States)

    Zheng, Zhichao; Diaz-Arévalo, Diana; Guan, Hongbing; Zeng, Mingtao

    2018-04-06

    The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future.

  7. A defense of compulsory vaccination.

    Science.gov (United States)

    Flanigan, Jessica

    2014-03-01

    Vaccine refusal harms and risks harming innocent bystanders. People are not entitled to harm innocents or to impose deadly risks on others, so in these cases there is nothing to be said for the right to refuse vaccination. Compulsory vaccination is therefore justified because non-vaccination can rightly be prohibited, just as other kinds of harmful and risky conduct are rightly prohibited. I develop an analogy to random gunfire to illustrate this point. Vaccine refusal, I argue, is morally similar to firing a weapon into the air and endangering innocent bystanders. By re-framing vaccine refusal as harmful and reckless conduct my aim is to shift the focus of the vaccine debate from non-vaccinators' religious and refusal rights to everyone else's rights against being infected with contagious illnesses. Religious freedom and rights of informed consent do not entitle non-vaccinators to harm innocent bystanders, and so coercive vaccination requirements are permissible for the sake of the potential victims of the anti-vaccine movement.

  8. The archetypal criticism of "Hooshroba Castle" story

    Directory of Open Access Journals (Sweden)

    Jalil Moshydy

    2017-04-01

    .“Universal archetypes are the collective unconscious and are inherited from our ancestors” (Cuddon, 1380: 39. The basic fact of life archetype such as birth, growing up, love, family and tribal life, death ...at the same concepts as the archetype known myths. Elements such as death and rebirth, hero's journey, an old wise man, anima and animus, shadow. The archetypal criticism based on inter-textuality to look at the literature and a relationship based on dialogue among literary works have been written based on archetypes believes. "Zat os-Sovar Castle" storyis one of the most mysterious talesof Masnavi and it is more mysteriously unfinished. Checking archetypal story of "Zat os-Sovar Castle"shows that archetype in this story has a special place. The story begins with the heroes of the adventure trip which is known archetypes. The old wise man in the form of three characters, namely the father, the old man will appear enlightened and king China. King of China's daughter the owner image of the beautiful castle, man is a manifestation of the female psyche Anima they say. Shadow of the dark side of the human psyche and the origin of evil traits, in the second brother to be seen and adverse effects on the soul leaves his. Mask or persona archetype also is seen in the behavior of the king of China When unaware that his show and the secret are their spiritual brothers. The loss of brothers and another brother replacing the frequently happens in the story, reminiscent of the archetype of death and rebirth is and in the end, according to the story's elements and characters, the myth of the creation of the first man to be seen. By analyzing this archetype can be hidden concepts in this part of the Masnavi and realized similar literary works and the benefit.

  9. Veterinary and human vaccine evaluation methods

    Science.gov (United States)

    Knight-Jones, T. J. D.; Edmond, K.; Gubbins, S.; Paton, D. J.

    2014-01-01

    Despite the universal importance of vaccines, approaches to human and veterinary vaccine evaluation differ markedly. For human vaccines, vaccine efficacy is the proportion of vaccinated individuals protected by the vaccine against a defined outcome under ideal conditions, whereas for veterinary vaccines the term is used for a range of measures of vaccine protection. The evaluation of vaccine effectiveness, vaccine protection assessed under routine programme conditions, is largely limited to human vaccines. Challenge studies under controlled conditions and sero-conversion studies are widely used when evaluating veterinary vaccines, whereas human vaccines are generally evaluated in terms of protection against natural challenge assessed in trials or post-marketing observational studies. Although challenge studies provide a standardized platform on which to compare different vaccines, they do not capture the variation that occurs under field conditions. Field studies of vaccine effectiveness are needed to assess the performance of a vaccination programme. However, if vaccination is performed without central co-ordination, as is often the case for veterinary vaccines, evaluation will be limited. This paper reviews approaches to veterinary vaccine evaluation in comparison to evaluation methods used for human vaccines. Foot-and-mouth disease has been used to illustrate the veterinary approach. Recommendations are made for standardization of terminology and for rigorous evaluation of veterinary vaccines. PMID:24741009

  10. Vaccines for preventing Japanese encephalitis

    DEFF Research Database (Denmark)

    Schiøler, Karin Linda; Samuel, Miny; Wai, Kim Lay

    2007-01-01

    BACKGROUND: Vaccination is recognized as the only practical measure for preventing Japanese encephalitis. Production shortage, costs, and issues of licensure impair vaccination programmes in many affected countries. Concerns over vaccine effectiveness and safety also have a negative impact...... on acceptance and uptake. OBJECTIVES: To evaluate vaccines for preventing Japanese encephalitis in terms of effectiveness, adverse events, and immunogenicity. SEARCH STRATEGY: In March 2007, we searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2007, Issue 1......), MEDLINE, EMBASE, LILACS, BIOSIS, and reference lists. We also attempted to contact corresponding authors and vaccine companies. SELECTION CRITERIA: Randomized controlled trials (RCTs), including cluster-RCTs, comparing Japanese encephalitis vaccines with placebo (inert agent or unrelated vaccine...

  11. A Lightweight Story-Comprehension Approach to Game Dialogue

    DEFF Research Database (Denmark)

    van Leeuwen, Robert P.; Cheong, Yun-Gyung; Nelson, Mark Jason

    2013-01-01

    In this paper we describe Answery, a rule-based system that allows authors to specify game characters' background stories in natural language. The system parses these background stories, applies transfor- mation rules to turn them into semantic content, and generates dialogue during gameplay...

  12. The Power of Story in the ESL Classroom

    Science.gov (United States)

    Nicholas, Bonnie J.; Rossiter, Marian J.; Abbott, Marilyn L.

    2011-01-01

    Although considerable research has examined the use of literature in the second language (L2) classroom, there has been less investigation into the integration of learners' personal stories in the English as a second language (ESL) classroom. Following Wajnryb's (2003) categorizations of story as language learning, genre, and the creation of what…

  13. Teaching Native American Music with Story for Multicultural Ends.

    Science.gov (United States)

    Boyea, Andrea

    2000-01-01

    States that the alliance between story and music within Native American culture can be carried over into the curriculum. Provides a rationale for utilizing story while teaching Native American music, specifically related to the multicultural curriculum. Discusses the value of cultural music to the multicultural curriculum. (CMK)

  14. Using Story Contexts to Bias Children's True and False Memories

    Science.gov (United States)

    Howe, Mark L.; Wilkinson, Samantha

    2011-01-01

    The effects of embedding standard Deese/Roediger-McDermott (DRM) lists into stories whose context biased interpretation either toward or away from the overall themes of the DRM lists on both true and false recognition were investigated with 7- and 11-year-olds. These biased story contexts were compared with the same children's susceptibility to…

  15. Stories in the Cloth: Art Therapy and Narrative Textiles

    Science.gov (United States)

    Garlock, Lisa Raye

    2016-01-01

    In this article I weave together the relevance of narrative textile work in therapeutic and human rights contexts; showcase Common Threads, an international nonprofit that uses story cloths with survivors of gender-based violence; outline a master's level art therapy course in story cloths; and relate how textiles helped build a sibling…

  16. Arguments as a new perspective on character motive in stories

    NARCIS (Netherlands)

    Bex, Floris; Atkinson, Katie; Bench-Capon, Trevor

    2014-01-01

    We often try to teach people through stories and narratives instead of giving them explicit facts and rules. But how do these stories influence us, how do they persuade us to change our attitudes? In this paper, we aim to answer these questions by providing a computational model that offers an

  17. Crossing Boundaries: A Variety of Perspectives on Preschool Stories

    African Journals Online (AJOL)

    denise

    preschool stories from multiple perspectives including the child featured in the story, the family of the child ... to take on a report card façade, returning to separation .... [and offer] children a way to revisit and reflect on ... years' teaching experience with a variety of ages and ...... inspiring children to “grow up as competent and.

  18. Personal Stories of Empathy in Adolescence and Emerging Adulthood

    Science.gov (United States)

    Soucie, Kendall M.; Lawford, Heather; Pratt, Michael W.

    2012-01-01

    Age-related and individual differences in adolescents' and emerging adults' stories of real-life empathic and nonempathic experiences were examined. A total of 29 adolescents (M = 15.28, SD = 0.99) and 31 emerging adults (M = 18.23, SD = 0.56) told stories of empathic and nonempathic life events and completed measures of authoritative parenting…

  19. Late commitment: virtual story characters that can frame their world

    NARCIS (Netherlands)

    Swartjes, I.M.T.; Theune, Mariet

    2009-01-01

    Our long-term aim is to build virtual agents that can partake together with human interactors as characters in a story, which emerges from their interactions wich each other and with the story world (the emergent narrative approach). Improvisational theatre -- as a real-life example -- suggests an

  20. One Classroom, One iPad, Many Stories

    Science.gov (United States)

    Fantozzi, Victoria B.; Johnson, Christi; Scherfen, Anneliese

    2018-01-01

    Every day, we are surrounded by stories in print, on social media, in blogs, on the radio, and in stories from our friends and family. The ways people make meaning and communicate are increasingly multimodal and digital; yet, the preschool classroom, for all its multimodal learning, is sometimes devoid of technology. In this action research…

  1. From mindtools to social mindtools: collaborative writing with Woven Stories

    CSIR Research Space (South Africa)

    Nuutinen, J

    2010-09-01

    Full Text Available . We present the concept of Woven Stories and use it as an example of an effective social mindtool. We also describe a case study in which Woven Stories software was used as an online debating forum. This case study reveals the potential inherent...

  2. Storying the Student Teaching Experience: Trying on Teaching Personae

    Science.gov (United States)

    Davis, Janine S.

    2013-01-01

    This article uses a narrative analysis approach to explore the stories of student teachers' experiences developing a teaching persona during student teaching. In keeping with the narrative format, the researcher presents the participants' stories in a first-person narrative. The participants had similar experiences in the realm of developing their…

  3. The Role of Interest in Learning Science through Stories

    Science.gov (United States)

    Klassen, Stephen; Klassen, Cathrine Froese

    2015-01-01

    A major aspect of the power of a historically based science story derives from its ability to cultivate interest in the reader or listener. In this paper, we review the research on interest originating from diverse scholarly areas and apply it to the understanding, construction, and effective use of science stories in both formal and informal…

  4. Editing Bosman's stories | MacKenzie | Current Writing: Text and ...

    African Journals Online (AJOL)

    This article looks back at the editing work that went into the fourteen-volume Anniversary Edition of Herman Charles Bosman (1998–2005) and pays particular attention to the editing of Bosman's stories. It examines some of the problems that were encountered in arriving at 'authoritative' versions of the stories and argues ...

  5. Stories and Science: Stirring Children's Imagination

    Science.gov (United States)

    Seeley, Claire; Gallagher, Sarah

    2014-01-01

    Stories are a place where magical things happen, where ideas are challenged, where the imagination runs free and questions are asked. They are a safe place, where the reader can walk about with new identities, try new ideas, process life's ups and downs and make new meanings. This makes stories the perfect place for creative learning. In this…

  6. Implications of the Social Web Environment for User Story Education

    Science.gov (United States)

    Fancott, Terrill; Kamthan, Pankaj; Shahmir, Nazlie

    2012-01-01

    In recent years, user stories have emerged in academia, as well as industry, as a notable approach for expressing user requirements of interactive software systems that are developed using agile methodologies. There are social aspects inherent to software development, in general, and user stories, in particular. This paper presents directions and…

  7. Becoming Black Women: Intimate Stories and Intersectional Identities

    Science.gov (United States)

    Wilkins, Amy C.

    2012-01-01

    In this article, I argue that intimate stories are an important resource for the achievement of intersectional identities. Drawing on in-depth interviews with black college students at two predominantly white universities, I examine the stories black college women tell about interracial relationships between black men and white women. I argue that…

  8. Story-Telling: A Method for Assessing Children's Creativity.

    Science.gov (United States)

    Hennessey, Beth Ann; Amabile, Teresa M.

    1988-01-01

    The subjective judgment of observers was used to assess verbal creativity. Students, aged 5-10, told a story to accompany a picture series. Teachers rated the stories relative to one another. Interjudge reliability of the creativity measure was highly satisfactory. Two subsequent studies affirmed the results, with slightly lower interjudge…

  9. How To Tell Your Literacy Stories through Radio.

    Science.gov (United States)

    Martini, Michael A.

    This paper offers advice to educators on how to tell their literacy stories through the medium of radio. It suggests educators examine their story idea closely and decide if radio is the best medium. It also suggests that educators should become familiar with the radio stations in the local market and get to know the personnel at the particular…

  10. Mark's story as oral traditional literature: Rethinking the transmission ...

    African Journals Online (AJOL)

    work to the analysis and interpretation of the Gospel of Mark, it is necessary to dis cuss his exposition in .... tions are met with time and again. ...... PJJBctha story when someone wants to tell the story - and that need arose very shortly after ... Christianity were apostles, prophets and disciples travelling and relying on sympathi.

  11. Social Stories for Reducing Fear in the Outdoors.

    Science.gov (United States)

    Chapman, Lawrence; Trowbridge, Marion

    2000-01-01

    Pupils with autistic spectrum disorders (ASD) fear the unknown and changes to their routine. Their fears may be unexpected, such as what is for breakfast. "Social stories" can alleviate such fears by giving a detailed account of each day's activities. A case study shows how a social story in diary form helped a boy with ASD cope with an outdoor…

  12. The varicella zoster vaccine

    African Journals Online (AJOL)

    Repro

    days. In patients who have received vari- cella zoster immunoglobulin (VZIG), the incubation period is ... his time working on. HIV-related .... The VZV vaccine results in long- lasting immunity ... Studies from Japan show protec- tion for 20 years ...

  13. Economics of vaccines revisited

    NARCIS (Netherlands)

    Postma, Maarten J.; Standaert, Baudouin A.

    2013-01-01

    Performing a total health economic analysis of a vaccine newly introduced into the market today is a challenge when using the conventional cost-effectiveness analysis we normally apply on pharmaceutical products. There are many reasons for that, such as: the uncertainty in the total benefit (direct

  14. Vaccines Help Protect Us

    Centers for Disease Control (CDC) Podcasts

    2013-04-23

    In this podcast for kids, the Kidtastics talk about the importance of vaccines and how they work.  Created: 4/23/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/23/2013.

  15. Advances in influenza vaccination

    NARCIS (Netherlands)

    L.A. Reperant (Leslie); G.F. Rimmelzwaan (Guus); A.D.M.E. Osterhaus (Albert)

    2014-01-01

    textabstractInfluenza virus infections yearly cause high morbidity and mortality burdens in humans, and the development of a new influenza pandemic continues to threaten mankind as a Damoclean sword. Influenza vaccines have been produced by using egg-based virus growth and passaging techniques that

  16. Immunology of BVDV vaccines

    Science.gov (United States)

    The use of vaccination to control bovine viral diarrhea virus (BVDV) infections presents exceptional challenges due to the nature of the virus, the unique interaction of the virus with the immune system, and its ability to establish persistent infections. The lack of proof reading function during th...

  17. Recombinant Breast Cancer Vaccines

    National Research Council Canada - National Science Library

    Pilon, Shari

    1999-01-01

    .... To generate cytosolic proteins, (cytE2, cytE2A), the ER signal sequence was deleted. Vaccination of BALB/c mice with DNA encoding transmembrane E2 or E2A induced anti-ErbB-2 antibodies and anti-tumor immunity, with E2 being more potent than E2A...

  18. Vaccines and multiple sclerosis

    DEFF Research Database (Denmark)

    Frederiksen, J. L.; Topsøe Mailand, M.

    2017-01-01

    An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live...

  19. Vaccines and multiple sclerosis

    DEFF Research Database (Denmark)

    Mailand, Mia Topsøe; Frederiksen, Jette Lautrup

    2017-01-01

    on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse...

  20. Tetanus, Diphtheria (Td) Vaccine

    Science.gov (United States)

    Decavac® (as a combination product containing Diphtheria, Tetanus Toxoids) ... Tenivac® (as a combination product containing Diphtheria, Tetanus Toxoids) ... Why get vaccinated?Tetanus and diphtheria are very serious diseases. They ... United States today, but people who do become infected often have severe ...