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Sample records for jung hs choi

  1. Jung in education

    DEFF Research Database (Denmark)

    Gitz-Johansen, Thomas

    2016-01-01

    This article is a review of the influence of analytical psychology within the field of education. The influence of analytical psychology on the mainstream of educational thought and practice has never been great. However, Jung himself gave a number of lectures on education and post-Jungians have...... further explored the relevance of analytical thought in education. The article first outlines Jung’s own thoughts about education and their reception in primarily North-America and England. The second half of the article discusses the post-Jungian contributions. Six different strands of post......-Jungian inspiration are identified: Mytho-historical education, holistic education, archetypal pedagogy, educating imagination, educating different personality types, and transformative education. Finally it is suggested, that while analytical psychology may never occupy a place in the mainstream of educational...

  2. Jung in education

    DEFF Research Database (Denmark)

    Gitz-Johansen, Thomas

    2016-01-01

    This article is a review of the influence of analytical psychology within the field of education. The influence of analytical psychology on the mainstream of educational thought and practice has never been great. However, Jung himself gave a number of lectures on education and post-Jungians have......-Jungian inspiration are identified: Mytho-historical education, holistic education, archetypal pedagogy, educating imagination, educating different personality types, and transformative education. Finally it is suggested, that while analytical psychology may never occupy a place in the mainstream of educational...... further explored the relevance of analytical thought in education. The article first outlines Jung’s own thoughts about education and their reception in primarily North-America and England. The second half of the article discusses the post-Jungian contributions. Six different strands of post...

  3. Jung, the Pentateuch and ethics

    Directory of Open Access Journals (Sweden)

    Eben Scheffler

    2004-10-01

    Full Text Available This article reflects on the contribution� that can� be made to the interpretation of the Bible by employing the analytical psychology of Carl Jung. After some relevant biographical considerations on Jung, his view of religion and the Bible is briefly considered, followed by a look into Genesis 1-3 in terms of his distinction of archetypes. It is suggested in the conclusion that Jungian psychological Biblical criticism can lead to a changed, but fresh view on the �authority� or influence of the Bible in the lives of (postmodern human beings and their (ethical behaviour.

  4. Jung, the Pentateuch and ethics

    Directory of Open Access Journals (Sweden)

    Eben Scheffler

    2004-10-01

    Full Text Available This article reflects on the contribution� that can� be made to the interpretation of the Bible by employing the analytical psychology of Carl Jung. After some relevant biographical considerations on Jung, his view of religion and the Bible is briefly considered, followed by a look into Genesis 1-3 in terms of his distinction of archetypes. It is suggested in the conclusion that Jungian psychological Biblical criticism can lead to a changed, but fresh view on the �authority� or influence of the Bible in the lives of (postmodern human beings and their (ethical behaviour.

  5. Teori Individuasi Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Ivan Th.J Weismann

    2009-10-01

    Full Text Available Masyarakat pada masa kini adalah masyarakat yang telah beralih dari masyarakat tradisional menjadi masyarakat modern. Masyarakat modern punya ciri khas tersendiri begitu pula dengan masyarakat pasca modern. C. G. Jung membahas tentang masyarakat yang berindividuasi. Apakah masyarakat yang berindividuasi itu adalah termasuk dalam salah satu ciri dari masyarakat modern.Individu yang mampu mengatasi persoalan masyarakat moderen ialah individu yang mencapai tahap-tahap proses individuasi ini atau yang disebut pula sebagai individu yang berindividuasi.

  6. Misunderstanding Jung: the afterlife of legends.

    Science.gov (United States)

    Shamdasani, S

    2000-07-01

    F. X. Charet's article, 'Understanding Jung: recent biographies and scholarship', is full of errors and legends. In this article, I demonstrate the tendentiousness of his criticisms of the historical work of Eugene Taylor and myself concerning Jung's linkages with the subliminal psychology of Théodore Flournoy, William James, and F. W. H. Myers, and the fallaciousness of his criticism of my claim that Memories, Dreams, Reflections was not Jung's autobiography.

  7. Gnostic inner illumination and Carl Jung's individuation.

    Science.gov (United States)

    Pennachio, J

    1992-09-01

    The ancient religious system of Gnosticism argued for the transcendence of the physical world and the divinity of self-knowledge. More recently, a similar argument was made by Carl Jung through his concept of individuation. This paper examines some of the similarities between Gnostic inner illumination and Jung's concept of individuation.

  8. Freud, Adler, Jung: From Womb to Tomb.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    This paper briefly introduces outlines of psychoanalysis (Freud), individual psychology (Adler), and analytical psychology (Jung). Freud focused on problems of adults as they related to childhood; Adler on problems of adults as they related to adulthood; and Jung on problems of adults as they related to middle and later years. Jungian analytical…

  9. Jung's quest for the "Aurora consurgens"

    DEFF Research Database (Denmark)

    Haaning, Aksel

    2014-01-01

    The paper focuses on the year 1929 when Jung published ‘A European commentary’ to Richard Wilhelm's German translation of the Taoist text The Secret of the Golden Flower. This shows that Jung had already started on the track of European alchemy by following up Conrad Waldkirch's preface in Artis ...

  10. CHOIS: enabling grid technologies for obesity surveillance and control.

    Science.gov (United States)

    Datta, Arun K; Jackson, Victoria; Nandkumar, Radha; Sproat, Jill; Zhu, Weimo; Krahling, Heidi

    2010-01-01

    CHOIS, the Child Health and Obesity Informatics System, is developed using open source portal technology with three-tiered Open Grid Services Architecture, an accepted standard for accessing Grid Computing and other services under Open Grid Collaborating Environments (OGCE). Its web application provides web based forms with 112 different fields to enter data ranging from demographic, height & weight for BMI, to genomic information. Automatic computation of BMI, BMI percentile and the risk of obesity alert are embedded into this system. After successful testing of the prototype, CHOIS is now ready to be used by the Illinois Department of Human Services (DHS) for obesity surveillance. This HIPAA & FERPA compliant secure system, integrating large databases in a high performance grid computing environment, enables school-nurse to collect data on school children and report statistical and surveillance information on BMI to identify those at-risk and obese for obesity prevention and intervention programs.

  11. [Carl Gustav Jung's alchemical thinking].

    Science.gov (United States)

    Mirkiewicz, Jakub

    2004-01-01

    Carl Gustav Jung (1875-1961), Swiss psychologist and philosopher of culture used in his concepts many constructs having their source in philosophy of alchemy. These ideas can be found not only in his books on alchemy but also in his psychological works. Among them we should enumerate: the theory of psychological process, the concepts of opposites coexisting in the psyche, the polar structure of notions in his psychological system and the idea of synchronicity. The author of this article examines these main points of Jungian program within the context of its parallelism with paracelsian alchemical philosophy of nature: the process of nature, alchemical dialectics and the universal analogy of micro- and macrocosmos. At the beginning of his work, creating his psychology Jung assumed similar ideas. Later, when he noticed this similarity, alchemy became very helpful in his research of psyche, because thanks to them he conceptualised the successive aspects of polar structure of dynamical psychical reality, which--like his alchemical predecessors--he used to explain basics of the micro- and macro-world.

  12. hs-CRP Test

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? hs-CRP Share this page: Was this page helpful? Also ... it used? A high-sensitivity C-reactive protein (hs-CRP) test may be used to help evaluate an ...

  13. mTOR-inhibitor treatment of metastatic renal cell carcinoma: contribution of Choi and modified Choi criteria assessed in 2D or 3D to evaluate tumor response

    Energy Technology Data Exchange (ETDEWEB)

    Lamuraglia, M. [Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France); Raslan, S.; Penna, R.R.; Wagner, M. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Elaidi, R.; Oudard, S. [APHP, Oncology Unit, Georges-Pompidou Hospital, Paris (France); Escudier, B. [Gustave-Roussy Institute, Medical Oncology Department, Villejuif (France); Slimane, K. [Novartis Pharma, Rueil-Malmaison (France); Lucidarme, O. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France)

    2016-01-15

    To determine whether 2D or 3D Choi and modified Choi (mChoi) criteria could assess the efficacy of everolimus against metastatic renal cell carcinoma (mRCC). RECIST-1.1, Choi, and mChoi criteria were applied retrospectively to analyse baseline and 2-month contrast-enhanced computed tomography (CECT) images in 48 patients with mRCC enrolled in the everolimus arm of the French randomized double-blind multicentre phase III trial comparing everolimus versus placebo (RECORD-1). The primary endpoint was centrally reviewed progression-free survival (PFS) calculated from the initial RECORD-1 analysis. Mean attenuation was determined for 2D target lesion regions of interest drawn on CECT sections whose largest diameters had been measured, and for the 3D whole target lesion. The median PFS was 5.5 months. The median PFS for everolimus responders defined using 3D mChoi criteria was significantly longer than for non-responders (7.6 versus 5.4 months, respectively), corresponding to a hazard ratio for progression of 0.45 (95 % CI: 0.22-0.92), with respective 1-year survival rates of 31 % and 9 %. No other 2D or 3D imaging criteria at 2 months identified patients who would benefit from everolimus. At 2 months, only 3D mChoi criteria were able to identify mRCC patients with a PFS benefit from everolimus. (orig.)

  14. HS3 Data Catalog

    Science.gov (United States)

    Emory, Amber Elizabeth; Chirica, Dan Cristian; Doyle, Jim

    2013-01-01

    This presentation covered the original plan for the Hurricane and Severe Storm Sentinel (HS3) Data Catalog available through the ESPO HS3 mission page (http://espo.nasa.gov/missions/hs3/) and provided examples of Model Products, Operational Products, and Research (Instrument) Products from the 2012 field campaign. The presentation also covered lessons learned and suggested improvements to the Data Catalog for the upcoming 2013 HS3 field campaign.

  15. Jung and Lévy-Bruhl.

    Science.gov (United States)

    Segal, Robert A

    2007-11-01

    For his knowledge of 'primitive' peoples, C. G. Jung relied on the work of Lucien Lévy-Bruhl (1857-1939), a French philosopher who in mid-career became an armchair anthropologist. In a series of books from 1910 on, Lévy-Bruhl asserted that 'primitive' peoples had been misunderstood by modern Westerners. Rather than thinking like moderns, just less rigorously, 'primitives' harbour a mentality of their own. 'Primitive' thinking is both 'mystical' and 'prelogical'. By 'mystical', Lévy-Bruhl meant that 'primitive' peoples experience the world as identical with themselves. Their relationship to the world, including to fellow human beings, is that of participation mystique. By 'prelogical', Lévy-Bruhl meant that 'primitive' thinking is indifferent to contradictions. 'Primitive' peoples deem all things identical with one another yet somehow still distinct. A human is at once a tree and still a human being. Jung accepted unquestioningly Lévy-Bruhl's depiction of the 'primitive' mind, even when Jung, unlike Lévy-Bruhl, journeyed to the field to see 'primitive' peoples firsthand. But Jung altered Lévy-Bruhl's conception of 'primitive' mentality in three key ways. First, he psychologized it. Whereas for Lévy-Bruhl 'primitive' thinking is to be explained sociologically, for Jung it is to be explained psychologically: 'primitive' peoples think as they do because they live in a state of unconsciousness. Second, Jung universalized 'primitive' mentality. Whereas for Lévy-Bruhl 'primitive' thinking is ever more being replaced by modern thinking, for Jung 'primitive' thinking is the initial psychological state of all human beings. Third, Jung appreciated 'primitive' thinking. Whereas for Lévy-Bruhl 'primitive' thinking is false, for Jung it is true--once it is recognized as an expression not of how the world but of how the unconscious works. I consider, along with the criticisms of Lévy-Bruhl's conception of 'primitive' thinking by his fellow anthropologists and

  16. Individuation:an Analysis of Passing Based on Jung`s Archetypes

    Institute of Scientific and Technical Information of China (English)

    XU Ya-fei

    2013-01-01

    This paper tries to interpreter Passing on the basis of Jungian archetypes. First this paper gives a brief introduction to Jung`s concept of individuation, then it analyses the archetypes:shadow, anima/animus, and persona of the individual respectively so that it shows that the individual has been through the process of individuation and finds her real self at last.

  17. Study protocol of the CHOiCE trial

    DEFF Research Database (Denmark)

    Nielsen, Mette Tranberg; Bech, Bodil Hammer; Blaakær, Jan;

    2016-01-01

    BACKGROUND: The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect......-up testing at 30, 60, or 90 days after mail out of the results. DISCUSSION: The CHOiCE trial will provide strong and important evidence allowing us to determine if and how HPV self-sampling can be used to increase participation in cervical cancer screening. This trial therefore has the potential to improve...... varies substantially among studies, especially depending on the approach used to offer HPV self-sampling. The present trial evaluates the effect on participation in an organized screening program of a HPV self-sampling kit mailed directly to the home of the woman or mailed to the woman's home on demand...

  18. [Eugen Bleuler and Carl Gustav Jung's habilitation].

    Science.gov (United States)

    Wilhelm, H R

    1996-01-01

    Eugen Bleuler's letter of recommendation for Carl Gustav Jung's appointment as a lecturer In January 1905, Eugen Bleuler (1857-1939) wrote a letter of recommendation to the Medical Faculty of the University of Zurich, urging them to accept the application of Carl Gustav Jung (1875-1961) as a lecturer there. Bleuler's letter mentions the contribution to Jung's writing made by Franz Riklin (1878-1938), although he does not define it precisely. It is safe to say that, judging from the way in which Bleuler expresses his opinions in this letter, this may be regarded at the very least as an early sign of his receptiveness to the psychoanalytical ideas of the time.

  19. The Pauli-Jung conjecture and its impact today

    CERN Document Server

    Fuchs, Christopher A

    2014-01-01

    Related to the key areas of Pauli''s and Jung''s joint interests, the book covers overlapping issues from the perspectives of physics, philosophy, and psychology. Of primary significance are epistemological questions connected to issues such as realism, measurement, observation, consciousness, and the unconscious. The contributions assess the extensive material that we have about Pauli''s and Jung''s ideas today, with particular respect to concrete research questions and projects based on and re...

  20. Gnosticism and psychology. Jung's Septem sermones ad mortuos.

    Science.gov (United States)

    Brenner, E M

    1990-10-01

    In this paper, I have attempted a historical analysis of what Jung might have been thinking when he wrote the 'Seven sermons'. To this end, I tried to ascertain which Gnostic texts Jung may have consulted before writing it. These documents were then compared with the 'Seven sermons', and numerous affinities noted between it and the Gnostic texts. Jung's contemporaneous academic works were then compared with this treatise, and parallels were established between the 'Seven sermons' and Jung's emerging psychology of the unconscious. In the process, an attempt was made to show how Jung made use of Gnostic themes in his emerging psychology. While there is no way of knowing precisely what Jung was thinking when he wrote the 'Seven sermons', it is clear that he was well acquainted not only with the work of Basilides, but also with the work of other Gnostic thinkers. It is not enough to assume that because Jung chose the pseudonym of Basilides, he was necessarily Jung's primary Gnostic influence. At the same time, it is also evident that Jung was developing his own psychology during the writing of the 'Seven sermons'. We recall Jung's observations regarding the 'Seven sermons', which we quoted on page 17: These conversations with the dead formed a kind of prelude to what I had to communicate to the world about the unconscious . . . All my works, all my creative activity, has come from those initial fantasies and dreams which began in 1912, almost fifty years ago. Everything that I accomplished in later life was already contained in them, although at first only in the form of emotions and images (Jung 21, p. 192). On the basis of what has been published, there are enough affinities between his academic work and this treatise to posit that the 'Seven sermons' played an important role in the emergence of Jung's psychology. Given these numerous parallels, I suspect that Jung's unpublished writings, including the Red Book, would only strengthen the arguments put forth in this

  1. Jung's psychological analysis of Imago Dei

    Directory of Open Access Journals (Sweden)

    Ivana Ryška Vajdová

    2016-05-01

    Full Text Available One of the most intricate topics that are still open in connection to a Swiss psychologist Carl Gustav Jung is religion and related issues: What is the relation between religion and psychology? What is Jung’s personal stance? Did Jung reject religion as a relict of primitive way of thinking or did he try to replace religion with psychology? Some speculations drawing primarily from Jung’s imagery and symbolism revealed in Liber Novus put forward the claim that he even aspired to found a new religion. This paper will attempt to square Jung’s attitude to religion, mainly Christianity. I will point out the main ideas of his psychology of religion. I will follow the evolution of particular ideas related to religion starting with his early works right through to his last.

  2. Archetypes and patriarchy: Eliade and Jung.

    Science.gov (United States)

    Meadow, M J

    1992-09-01

    This paper first presents the understandings of the concept of archetype held by Carl Jung and Mircea Eliade. After comparing their use of the term, the paper next presents some major archetypes concerning sex roles that each theorist describes. The problems such notions create for women are analyzed. The paper ends with a discussion of some possible solutions to the difficulties caused by the human proclivity for archetypal imaging.

  3. Two Jungs. Apropos a paper by Mark Saban.

    Science.gov (United States)

    Giegerich, Wolfgang

    2015-06-01

    Jung's idea of the 'personal equation' amounts to the reflection that theoretical differences between the psychologies that people teach are rooted in their personalities, in other words, that they are due to the psychology each one 'has'. This concept also applies to different interpretations of Jung's work. The serious difficulties that Mark Saban has with my psychology are a case in point. Recourse to the concept of the personal equation reveals that Saban has his Jung and I have mine. With his insistence on his Talmudic methodological principle of dream interpretation, that 'the dream is its own interpretation', according to Saban Jung means nothing but a rejection of Freudian free association. My Jung goes far beyond that. Jung understands this methodological principle above all in terms of what he calls 'circumambulation'. The main part of this paper is devoted to an elucidation of what circumambulation involves as a mode of dream interpretation. The paper concludes with the distinction Jung himself introduced between two types of reading of his work, either as 'paper' and 'dead nostrums' or as 'fire and wind', and pleads for a reconstruction of Jung's psychology as a whole in terms of his most advanced, deepest insights, instead of a dogmatic reading mainly based on the early Jung, a reading for which his later revolutionary insights are at best negligible embellishments. © 2015, The Society of Analytical Psychology.

  4. Jung's view on myth and post-modern psychology.

    Science.gov (United States)

    Jones, Raya A

    2003-11-01

    Post-modern psychology embodies two core themes, the social mind and the narrative self. Whereas the social-mind thesis seems diametrically opposed to Jung's position regarding human nature, the narrative-self thesis is associated with research and theorizing about personal myth and mythmaking in ways that could make contact with Jung's concerns. Jung's view is examined here with particular attention to McAdams' theory of narrative identity. It is suggested that the ostensible differences between Jung and post-modern psychology might reflect divergent interests, rather than necessarily irreconcilable worldviews.

  5. SN 2011hs

    DEFF Research Database (Denmark)

    Bufano, F.; Pignata, G.; Bersten, M.

    2014-01-01

    Observations spanning a large wavelength range, from X-ray to radio, of the Type IIb supernova 2011hs are presented, covering its evolution during the first year after explosion. The optical light curve presents a narrower shape and a fainter luminosity at peak than previously observed for Type I...

  6. Jung's views of Nazi Germany: the first year and Jung's transition.

    Science.gov (United States)

    Schoenl, William; Schoenl, Linda

    2016-09-01

    This article first considers Jung's response to the coming to power of the Nazis in Germany. It brings forth evidence that, besides wanting to preserve psychotherapy in Germany and maintain the international connection between the German and other communities of psychotherapists, he wanted to advance Jungian psychology - his psychology - in Germany. It also presents evidence that, although he occasionally made some anti-Semitic statements during this early period, he was not anti-Semitic in the way the Nazis were. The paper then argues that after Gustav Bally's criticisms in the Neue Zuercher Zeitung in February 1934, Jung entered into a transitional period that spring during which he became warier both of the Nazis and of making any statements that could be construed as being anti-Semitic. Schoenl and Peck (2012) have shown how Jung's views of Nazi Germany changed from 1933 to March 1936. This present article demonstrates very significant changes in Jung's views during the important early part of this period, that is from January 1933 - when Hitler became Chancellor of Germany - through to the spring of 1934. It draws on evidence from archival and other primary sources.

  7. La escuela de Carl G. Jung

    Directory of Open Access Journals (Sweden)

    Andrés Ortiz Osés

    2001-01-01

    Full Text Available En este artículo se presenta la Escuela de C.G.Jung como un movimiento que, siguiendo al psicólogo suizo, trata de coimplicar inconsciente y consciente en un lenguaje simbólico de sentido. Como representante de la Escuela junguiana se ofrece la psicología de Erich Neumann, perteneciente al Círculo Eranos y especializado en el estudio de la correlación entre la urdimbre matriarcal y la estructura patriarcal, cuya síntesis anímica constituye el sentido.

  8. Jung's Psychology and Deleuze's Philosophy: The Unconscious in Learning

    Science.gov (United States)

    Semetsky, Inna; Delpech-Ramey, Joshua A.

    2012-01-01

    This paper addresses the unconscious dimension as articulated in Carl Jung's depth psychology and in Gilles Deleuze's philosophy. Jung's theory of the archetypes and Deleuze's pedagogy of the concept are two complementary resources that posit individuation as the goal of human development and self-education in practice. The paper asserts that…

  9. Jung's and Freud's contributions to dream interpretation: a comparison.

    Science.gov (United States)

    Weitz, L J

    1976-04-01

    Carl G. Jung considers dreams as (a) aids to restoring and maintaining mental health, (b) as scientific insights into psychic casuality, (c) as symbolic representations of one's actual subjective state and (d) as expressions of "telepathic visions". In this paper Jung's considerations are contrasted to Freud's.

  10. Winnicott on Jung: destruction, creativity and the unrepressed unconscious.

    Science.gov (United States)

    Meredith-Owen, William

    2011-02-01

    This paper considers Winnicott's critique of Jung, principally expressed in his review of Memories, Dreams, Reflections, which asserts that Jung's creative contribution to analysis was constrained by his failure to integrate his 'primitive destructive impulses', subsequent to inadequate early containment. It is argued that although Winnicott's diagnosis illuminates Jung's shadow, particularly his constraints vis-à-vis the repressed Freudian unconscious, it fails to appreciate the efficacy of the compensatory containment Jung found in the collective unconscious. This enigmatic relationship between destruction and creativity-so central to late Winnicott-is illuminated by Matte Blanco's bi-logic, and further explored in relation to William Blake. Winnicott's personal resolution through his Jung-inspired 'splitting headache' dream of destruction-previously considered in this Journal by Morey (2005) and Sedgwick (2008)-is given particular attention.

  11. Another serious misunderstanding: Jung, Giegerich and a premature requiem.

    Science.gov (United States)

    Saban, Mark

    2015-02-01

    Barreto's paper, 'Requiem for analytical psychology' utilized Jung's dreams and visions to argue for the obsolescence of Jungian psychology. Its thesis rested upon the theoretical assumptions of Giegerich's psychology as a Discipline of Interiority, which he and Giegerich claim are themselves based in Jung's psychology. Here I argue that that claim is misplaced because it depends upon a fundamental misunderstanding of the nature of Jung's psychological project. I shall further argue that Giegerich's arguments for a Jungian basis to his psychology rely upon misreadings and decontextualisations of Jung's original texts. Finally, I shall attempt to draw attention to the weaknesses and contradictions involved in Barreto's interpretations of Jung's dreams and visions. © 2015, The Society of Analytical Psychology.

  12. Jung, vitalism and 'the psychoid': an historical reconstruction.

    Science.gov (United States)

    Addison, Ann

    2009-02-01

    This paper traces the history of Jung's ideas concerning the psychoid unconscious, from their origins in the work of the vitalist, Hans Driesch, and his concept of Das Psychoid, through the subsequent work of Eugen Bleuler, Director of the Burghölzli Asylum, and his concept of Die Psychoide, to the publication of Jung's paper On the Nature of the Psyche in 1947. This involves a review of Jung's early work and of his meeting with Freud, when apparently the two men discussed calling the unconscious 'psychoid', as well as a review of Jung's more mature ideas concerning a psychoid unconscious. I propose to argue that even at the time of their meeting, Jung had already formulated an epistemological approach that was significantly different from that of Freud and that clearly foreshadowed his later ideas as set out in On the Nature of the Psyche.

  13. A visit paid to Jung by Alwine von Keller.

    Science.gov (United States)

    Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

    2011-04-01

    In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis.

  14. Winnicott's invitation to 'further games of Jung-analysis'.

    Science.gov (United States)

    Meredith-Owen, William

    2015-02-01

    Winnicott signs off his celebrated review of Jung's (1963) autobiography Memories, Dreams, Reflections with the warning that translation of 'erreichten' as 'attained' (implying assimilation) rather than as 'reached to', could 'queer the pitch for further games of Jung-analysis'. This subtly underscores his view that Jung--who he described earlier as 'mentally split' and lacking 'a self with which to know'--remained essentially dissociated. However, Winnicott, whilst immersed in this work on Jung, wrote a letter to Michael Fordham describing himself as suffering 'a lifelong malady' of 'dissociation'. But this he now reported repaired through a 'splitting headache' dream of destruction, dreamt 'for Jung, and for some of my patients, as well as for myself' (Winnicott 1989, p. 228). Winnicott's recurrent concern during his last decade was with 'reaching to'--that quintessential Winnicottian term--some reparative experience that could address such difficulties in constellating a 'unit self'. This is correlated with his engagement with Jung and tracked through his contemporaneous clinical work, particularly 'Fear of Breakdown' (1963). Themes first introduced by Sedgwick (2008) and developed by the author's earlier 'Winnicott on Jung; destruction, creativity and the unrepressed unconscious' (2011) are given further consideration.

  15. C. G. Jung: the Man and His Work, Then and Now.

    Science.gov (United States)

    Alexander, Irving E.

    This paper discusses the life of Carl Jung, analyzing the relationship to his work of selected events in his life. Biographical elements of Jung's life such as his family and childhood experiences are described, and specific incidents that Jung reported to have had a great impact on his emotional health are highlighted. Jung's professional…

  16. Jung, weiblich und Journalistin: Endstation Prekariat?

    Directory of Open Access Journals (Sweden)

    Martina Lettner

    2012-09-01

    Full Text Available Die Medienbranche ist seit nunmehr vier Jahrzehnten von Wandlungsprozessen gekennzeichnet. Dabei sind die strukturellen Umbrüche im Bereich der Massenmedien bereits Grundlage zahlreicher wissenschaftlicher Arbeiten zum journalistischen Feld; die zunehmende Ungleichheit, die vor allem weibliche Akteure innerhalb des Feldes in Österreich erleben, wurde bisher jedoch nicht eingehend thematisiert. Aufbauend auf den Datensätzen, die 2010 an der Universität Salzburg gewonnen wurden (vgl. Hummel et al. 2010, und der Theorie des französischen Soziologen Pierre Bourdieu werden im folgenden Beitrag Struktur dieser Ungleichheit – derzeit sind junge Frauen im von älteren Männern dominierten journalistischen Feld Österreichs doppelt benachteiligt –, ihre Ursachen, Reproduktionsmechanismen und mögliche Gegenstrategien aufgezeigt.

  17. Analysis and Visualization of Network Data Using JUNG

    Directory of Open Access Journals (Sweden)

    Pinaz Sayma

    2014-08-01

    Full Text Available The JUNG (Java Universal Network/Graph Framework is a free, open-source software library that provides a common and extendible language for the manipulation, analysis, and visualization of data that can be represented as a graph or network. It is written in the Java programming language, allowing JUNG-based applications to make use of the extensive built-in capabilities of the Java Application Programming Interface (API, as well as those of other existing third-party Java libraries. In this paper, the JUNG Framework is described which is used to visualize data.

  18. The Application of Jung's Analytical Psychology to Education.

    Science.gov (United States)

    Shaker, Paul

    1982-01-01

    Discusses the application of Jungian analytical psychology to education. The author outlines Jung's concepts which relate to the foundations of education, personality development, cognitive processes, motivation, and curriculum theory. (AM)

  19. Jaan Jung. Muinasaja teadus eestlaste maalt III / Villem Reiman

    Index Scriptorium Estoniae

    Reiman, Villem, 1861-1917

    2015-01-01

    Jaan Jungi elust ja tegevusest ning tema raamatust: Muinasajateadus eestlaste maalt : III, Kohalised muinasaja kirjeldused Tallinnamaalt / Kogunud ja välja annud J. Jung. Tallinn : A. Busch'i rmtkpl., 1910

  20. The Face We Put On: Carl Jung for Teachers.

    Science.gov (United States)

    Craig, Robert P.

    1994-01-01

    Examines Carl Jung's concept of the "persona" (his term for the masks people wear). Notes how teachers use personae and suggests ways to restore the energy that teachers lose when hiding inside their personae. (SR)

  1. "Decknamen or pseudochemical language"? Eirenaeus Philalethes and Carl Jung.

    Science.gov (United States)

    Newman, W R

    1996-01-01

    It is impossible to investigate the historiography of alchemy without encountering the ideas of the "father of analytical psychology", Carl Jung. Jung argued that alchemy, viewed as a diachronic, trans-cultural entity, was concerned more with psychological states occurring in the mind of the practitioner than with real chemical processes. In the course of elucidating this idea, Jung draws on a number of alchemical authors from the early modern period. One of these is Eirenaeus Philalethes, the pen name of George Starkey (1628-1665), a native of Bermuda who was educated at Harvard College, and who later immigrated to London. A careful analysis of Starkey's work shows, however, that Jung was entirely wrong in his assessment of this important representative of seventeenth-century alchemy. This finding casts serious doubt on the Jungian interpretation of alchemy as a whole.

  2. Jaan Jung. Muinasaja teadus eestlaste maalt III / Villem Reiman

    Index Scriptorium Estoniae

    Reiman, Villem, 1861-1917

    2015-01-01

    Jaan Jungi elust ja tegevusest ning tema raamatust: Muinasajateadus eestlaste maalt : III, Kohalised muinasaja kirjeldused Tallinnamaalt / Kogunud ja välja annud J. Jung. Tallinn : A. Busch'i rmtkpl., 1910

  3. From Moscovici to Jung: the feminine archetype and its iconography

    National Research Council Canada - National Science Library

    Jesús Saiz Galdós; Beatriz Fernández Ruiz; José Luis Álvaro Estramiana

    2007-01-01

    .... Using Jung's concept of archetype to analyse women´s iconographic representations allows us to combine the notion of the collective unconscious with that of social representations. Whereas Moscovici...

  4. [Salzburg 1908. Karl Abraham caught between Freud and Jung].

    Science.gov (United States)

    van Schoonheten, Anna Bentinck

    2010-01-01

    The first psychoanalytic congress in Salzburg has often been described as a great success with one blemish: a conflict between Jung and Abraham, mainly caused by the rivalry in Abraham's behaviour. A new study of the material, and taking Abraham's perspective, provides a different view. Abraham, still a beginner in psychoanalysis, got in the way of Freud and Jung who at that time had a deep theoretical disagreement. In the end they both blamed Abraham.

  5. Analysis and Visualization of Network Data Using JUNG

    OpenAIRE

    Pinaz Sayma

    2014-01-01

    The JUNG (Java Universal Network/Graph) Framework is a free, open-source software library that provides a common and extendible language for the manipulation, analysis, and visualization of data that can be represented as a graph or network. It is written in the Java programming language, allowing JUNG-based applications to make use of the extensive built-in capabilities of the Java Application Programming Interface (API), as well as those of other existing third-party Java li...

  6. Jung's twin brother. Otto Gross and Carl Gustav Jung. With an hitherto unpublished letter by C. G. Jung.

    Science.gov (United States)

    Heuer, G

    2001-10-01

    This paper is a preliminary communication of several years of research into the life and work of the Austrian psychoanalyst and anarchist Otto Gross (1877-1920). Although he played a pivotal role in the birth of modernity, acting as a significant influence upon psychiatry, psychoanalysis, ethics, sociology and literature, he has remained virtually unknown to this day. Following a biographical sketch and an overview of his main theoretical contributions, the impact of Gross' life and work on the development of analytical theory and practice is described. His relationship with some of the key figures in psychoanalysis is presented, with particular emphasis on his connections to Jung. The paper concludes with an account of relevant contemporary interest in his work: the founding of the International Otto Gross Society, the first edition of The Collected Works of Otto Gross on the Internet, and the 1st and 2nd International Otto Gross Congresses which took place in Berlin in 1999 and at the Burghölzli Clinic, Zürich, in October 2000.

  7. Junge relationships in measurement data for cyclic siloxanes in air.

    Science.gov (United States)

    MacLeod, Matthew; Kierkegaard, Amelie; Genualdi, Susie; Harner, Tom; Scheringer, Martin

    2013-10-01

    In 1974, Junge postulated a relationship between variability of concentrations of gases in air at remote locations and their atmospheric residence time, and this Junge relationship has subsequently been observed empirically for a range of trace gases. Here, we analyze two previously-published datasets of concentrations of cyclic volatile methyl siloxanes (cVMS) in air and find Junge relationships in both. The first dataset is a time series of concentrations of decamethylcyclopentasiloxane (D5) measured between January and June, 2009 at a rural site in southern Sweden that shows a Junge relationship in the temporal variability of the measurements. The second dataset consists of measurements of hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4) and D5 made simultaneously at 12 sites in the Global Atmospheric Passive Sampling (GAPS) network that shows a Junge relationship in the spatial variability of the three cVMS congeners. We use the Junge relationship for the GAPS dataset to estimate atmospheric lifetimes of dodecamethylcyclohexasiloxane (D6), 8:2-fluorotelomer alcohol and trichlorinated biphenyls that are within a factor of 3 of estimates based on degradation rate constants for reaction with hydroxyl radical determined in laboratory studies.

  8. Jung as psychologist of religion and Jung as philosopher of religion.

    Science.gov (United States)

    Segal, Robert A

    2010-06-01

    Is it possible to be both a psychologist and a philosopher? Is it possible for a psychologist, or more generally a social scientist, to use social scientific findings to make philosophical claims? Specifically, is it possible for a social scientist to use social scientific findings to determine the existence of God? Did Jung profess to be only a psychologist or also a philosopher? If he professed to be both, did he enlist his psychological findings to make philosophical claims? Specifically, did he enlist his psychological findings to determine the existence of God?

  9. Two in one or one in two? Pushing off from Jung with Wolfgang Giegerich.

    Science.gov (United States)

    Saban, Mark

    2015-11-01

    This paper responds to a recent paper by Wolfgang Giegerich entitled 'Two Jungs: apropos a paper by Mark Saban'. Giegerich disputes my assertion that the 'rigorous notion' at the heart of his psychology 'finds no source in Jung's psychology, implicit or explicit'. In order to do this he posits the existence of two Jungs, an exoteric Jung and an esoteric Jung. The implications of Giegerich's binary scission of Jung are explored in this paper, and show that the tendency to exalt one Jung while disparaging the other betrays a comprehensive blindness toward the contradictory complexity of Jung's psychology as a whole. It is suggested that this blindness is the consequence of Giegerich's systematic prioritization of a neo-Hegelian agenda that is in profound conflict with the telos of Jung's psychology.

  10. Code Optimization for the Choi-Williams Distribution for ELINT Applications

    Science.gov (United States)

    2009-12-01

    PAGES 98 14. SUBJECT TERMS Choi-Williams Distribution, Signal Processing, Algorithm Optimization, C programming , Low Probability of Intercept (LPI...not be useful for the C programming language, but was included in this thesis because it could be useful when developing a hardware solution to these...representation. Since there is no such single operation in the C programming language, to utilize this method would involve masking out the eight-bit

  11. Sabina Spielrein: out from the shadow of Jung and Freud.

    Science.gov (United States)

    Skea, Brian R

    2006-09-01

    Since the 1982 publication of Aldo Carotenuto's book, A Secret Symmetry: Sabina Spielrein Between Jung and Freud, there has been renewed interest in the life and work of Sabina Spielrein. She was Jung's first psychoanalytic case at the Burghölzli Hospital in 1904, and was referred to several times in The Freud/Jung Letters. Spielrein recovered, enrolled in medical school, and went on to become a Freudian analyst. Her most famous paper, published in 1912, 'Destruction as a cause of coming into being', was referred to by Freud in 1920 in relation to his Death Instinct theory. In the few Freudian publications on this controversial theory since 1920, Spielrein's contribution is consistently omitted. Jung also neglected to refer to her 'Destruction' paper in his early 1912 version of 'Symbols of transformation', even though he had edited her paper and had promised to acknowledge her contribution. He did refer extensively to Spielrein's first paper, her medical thesis, 'On the psychological content of a case of schizophrenia', published in 1911, as yet unpublished in English. In her paper Spielrein sought to understand the psychotic delusions of Frau M, a patient at the Burghölzli, much in the style of Jung's 'Psychology of dementia praecox' (1907). The purpose of this paper is to explore to what extent Spielrein's Frau M paper, and its companion 'Destruction' paper, make an original contribution to both Jung and Freud's emerging theories on the possible creative versus destructive outcomes of neurotic or psychotic introversion, culminating in Jung's concept of the 'collective unconscious' (1916) and Freud's concept of a 'Death instinct' (1920).

  12. Jung, Evans-Wentz and various other gurus.

    Science.gov (United States)

    McGuire, William

    2003-09-01

    How did Jung become deeply concerned with Asian religions and particularly with the Tibetan Buddhism of a Welshman from Trenton, New Jersey? Could that man be considered one of Jung's gurus? This essay begins six years after Jung, at twenty, was admitted to the medical school of Basel University and became a member of the Zofingiaverein, a student society. The next year he gave the first of a series of lectures on the interpretation of Christ as the model of the 'god-man', like the Apostle Paul, Confucius, Zoroaster and the Buddha, who was 'drummed into the Hindu boy'. (Jung's Zofingia Lectures were discovered only after his death, in 1961, and were published in English in 1983). The present essay discusses Jung's early Buddhist interest as displayed in The Psychology of the Unconscious (finally, in a revision, entitled Symbols of Transformation), in Psychological Types and later in his foreword of the Wilhelm translation of the I Ching. Jung was influenced by the gurus Richard Wilhelm and his son Hellmut, the scholar J. W. Hauer (with whom he later broke off relations because of Hauer's Nazi politics), the indologist Heinrich Zimmer, and the Zen master D. T. Suzuki. Walter Yeeling Wentz was born in Trenton in 1878 and brought up in his family's theosophist faith. The Wentzes moved to San Diego in 1900, and Walter added his mother's Celtic surname, Evans, to the German Wentz. He was educated at Stanford University and travelled in Europe, studying Celtic folklore, and widely in the Near East, Tibet, India, and Oxford--studying religions everywhere and editing Tibetan books. He lived his last decades in San Diego and conducted a correspondence with Jung, while living in a cheap hotel, or in an ashram.

  13. Jung's very twentieth-century view of myth.

    Science.gov (United States)

    Segal, Robert A

    2003-11-01

    It is commonly assumed that Jung's view of myth, like his view of everything else, is best understood vis-à-vis Freud's. I argue that Jung in fact positions himself much more broadly, not merely against other psychologists of myth but more fundamentally against non-psychologists altogether. Undeniably, Jung pits his theory against Freud's, but only after pitting both his theory and Freud's against those theories that assume the subject matter of myth to be the external world rather than the human mind and that assume the function of myth to be either the explanation or the description of the external world rather than the expression of the human mind. The theorists whom Jung challenges are called 'nature mythologists', for whom myth is either a literal explanation or a symbolic description of the natural world. Which element of the natural world myth is about varies from nature mythologist to nature mythologist. The two leading nature mythologists, both of whom Jung cites, were Edward Tylor and James Frazer. Their theories epitomize the nineteenth-century approach to myth. For them, myth is the 'primitive' counterpart to science, which is entirely modern. For them, myth and science are incompatible, science is true and myth false, and myth must therefore go when science comes. Jung's rejection of the external world as the referent of myth and of explanation or description of that world as the function of myth epitomizes the twentieth-century response to nineteenth-century theories. For not merely Jung and Freud but also twentieth-century theorists generally, myth is anything but the 'primitive' counterpart to modern science. Consequently, myth and science are not rivals, so that myth need not go when science comes.

  14. The Dynamic Growth Exhibition and Accumulation of Cadmium of Pak Choi (Brassica campestris L. ssp. chinensis Grown in Contaminated Soils

    Directory of Open Access Journals (Sweden)

    Hung-Yu Lai

    2013-10-01

    Full Text Available The accumulation of heavy metals, especially cadmium (Cd, in leafy vegetables was compared with other vegetables. Pak choi (Brassica campestris L. ssp. chinensis is a leafy vegetable consumed in Taiwan and its safety for consumption after growing in contaminated soils is a public concern. A pot experiment (50 days was conducted to understand the dynamic accumulation of Cd by pak choi grown in artificially contaminated soils. The edible parts of pak choi were sampled and analyzed every 2–3 days. The dry weight (DW of pak choi was an exponential function of leaf length, leaf width, and chlorophyll content. The accumulation of Cd increased when the soil Cd concentration was raised, but was kept at a constant level during different growth stages. Pak choi had a high bioconcentration factor (BCF = ratio of the concentration in the edible parts to that in the soils, at values of 3.5–4.0. The consumption of pak choi grown in soils contaminated at levels used in this study would result in the ingestion of impermissible amounts of Cd and could possibly have harmful effects on health.

  15. Jung, spirits and madness: lessons for cultural psychiatry.

    Science.gov (United States)

    Koss-Chioino, Joan D

    2003-06-01

    An understanding of the nature and meaning of 'dissociative,' 'altered' or unusual states ultimately turns on the meaning and definition of consciousness. The view of consciousness from the discipline of psychiatry is largely based on a biomedically endorsed, culturally specific perspective of 'normal' consciousness as an integrated pattern of quotidian relationships with the 'observable' physical world. This perspective underlies the nosology for mental disorders, particularly psychoses, suggesting irreconcilable difference in cognition and affect of persons with these diagnostic labels. This article reviews some theories of Carl Gustav Jung regarding the structure and content of human consciousness and their relationship to aspects of 'dementia praecox' or 'schizophrenia.' It traces the origin and development of these ideas in part to Jung's early contact with, and intense interest in spiritualists and spirits, to later influences comprised of his own altered states (dreams and fantasies) and his involvement with patients diagnosed as schizophrenic. Data on current Spiritist beliefs and healing practices focused on 'madness' (i.e. most often diagnosed as schizophrenia in mental health settings), are described to explore parallels with Jung's ideas on the structure and dynamics of the psyche. These parallels are of special interest because the experience of spirits is ubiquitous, not well explained and often rejected as meaningful by psychiatrists and clinical psychologists. Jung, however, offers a cogent explanation of spirit phenomena as manifestations of the unconscious. A concluding section suggests contributions to cultural psychiatry by Jung.

  16. Pauli and Jung the meeting of two great minds

    CERN Document Server

    Lindorff, David

    2004-01-01

    The pioneering work of Nobel prize-winning physicist Wolfgang Pauli led to developing the bombs that decimated Hiroshima and Nagasaki. Desperate over this outcome, Pauli sought help from the eminent depth psychologist, C. G. Jung. Their long correspondence provides the powerful and unique record of a mature scientist's inner journey. It also has had a tremendous impact on scientific and psychological thought ever since. Pauli and Jung is a lucid interpretation of Pauli's ideas and dreams that forcefully validates his belief in the inseparable union of science and spirituality. Far ahead of their time, Wolfgang Pauli and C. G. Jung both knew this union is essential for the future of humanity and the survival of the planet.

  17. Carl Gustav Jung and Granville Stanley Hall on Religious Experience.

    Science.gov (United States)

    Kim, Chae Young

    2016-08-01

    Granville Stanley Hall (1844-1924) with William James (1842-1910) is the key founder of psychology of religion movement and the first American experimental or genetic psychologist, and Carl Gustav Jung (1875-1961) is the founder of the analytical psychology concerned sympathetically about the religious dimension rooted in the human subject. Their fundamental works are mutually connected. Among other things, both Hall and Jung were deeply interested in how the study of religious experience is indispensable for the depth understanding of human subject. Nevertheless, except for the slight indication, this common interest between them has not yet been examined in academic research paper. So this paper aims to articulate preliminary evidence of affinities focusing on the locus and its function of the inner deep psychic dimension as the religious in the work of Hall and Jung.

  18. Jung, mandala e arquitetura Islâmica

    Directory of Open Access Journals (Sweden)

    Rafael Raffaelli

    2009-03-01

    Full Text Available Este artigo se propõe a refletir sobre as origens do conceito junguiano de mandala. Utiliza-se o relato autobiográfico de Jung, Memórias, Sonhos e Reflexões, e sua obra Psicologia e Alquimia para traçar essa origem. Segundo Barbara Hannah, biógrafa de Jung, uma mesquita no Cairo (Egito foi de importância capital para a formulação desse conceito. Provavelmente esse templo é a Mesquita Ahmad Ibn Tulun. É analisada a relação entre a simbologia arquitetônica islâmica inspirada pelo sufismo e as concepções psicológicas de Jung.

  19. Jung i Bachelard. Problem wyobraxni i mitu (JUNG AND BACHELARD. THE PROBLEM OF IMAGINATION AND MYTH

    Directory of Open Access Journals (Sweden)

    Ilona Błocian

    2005-06-01

    Full Text Available The article is devoted to some specific 'area between' interpretative achievements of Freud, Jung and Bachelard. The imagination and myth problems are involved in more general perspective of philospophical conception of man in their works. Different models of human reason and imagination idealizing forces influenced procedures of an imaginal thinking and image itself interpretations. The basis of comparation is the unconscious (Freudian 'repressed unconscious', Jungian collective unconsciuos, complex and archetype conceptions as some kind of instruments to understand image formating process, phantasies, mythical and poetical image. An example of these differences is their interpretations of Promethean myth. A way of understand dream image, Anima and Animus archetypes refer to their specific theoretical frames.

  20. [Carl Gustav Jung, the myth of a man].

    Science.gov (United States)

    Loza, Julieta

    2012-01-01

    The aim of this article is to get closer to the myth of Jung, this is part of the inner experiences that took place in his first childhood, and in which we can already see the foundation of his work and the development of key concepts as: the unconscious, Self, archetype and individuation process. His life is the display of his unconscious and this is what his work is about. We cannot understand Jung without taking into account the fundamental importance that he gives to the inner world: the dreams and fantasies; and the direct contact that he has had with these aspects since he was a little boy.

  1. The anthropology of Carl Jung: Implications for pastoral care.

    Science.gov (United States)

    Hunt-Meeks, S

    1983-09-01

    This article examines the basic tenets of Carl Jung's anthropology, including intrapsychic structure, relationships, society, and the process of individuation. It then turns to his ideas about God and religion. Jung builds his understanding of God from his work in psychology, and because of that method, there are several major problems with his theologizing. Nevertheless, his insights are extremely valuable to the field of pastoral care, and ministers would do very well to appreciate his contribution, though always with a critical eye to its limitation.

  2. The professionalization of Carl G. Jung's analytical psychology clubs.

    Science.gov (United States)

    Samuels, A

    1994-04-01

    This paper addresses (1) the history of a cluster of unusual institutions-analytical psychology clubs--which started in 1916 and by 1934 had become established in many of the countries in the world in which there was interest in the analytical psychology of Carl G. Jung; (2) the conflicts involved in trying to unite the relatively informal earlier "Jung Clubs" with the more formal societies being established by the increasing numbers of professionally trained analysts; and (3) the wider cultural and social issues included in the professionalization of analytical psychology.

  3. Mind as Medium: Jung, McLuhan and the Archetype

    OpenAIRE

    Braga,Adriana

    2016-01-01

    The Greek notion of archetype was adopted and popularized in the context of the analytical psychology of Carl Gustav Jung. Marshall McLuhan used the concept archetype as a formal perspective rather than the content of an alleged “collective unconscious”. In his book From Cliché to Archetype, the idea of archetype is presented as the ground where individual action is the figure. This article, departing from the notion of archetype, explores some convergences between the thought of Carl Jung an...

  4. The value of confession and forgiveness according to Jung.

    Science.gov (United States)

    Todd, E

    1985-03-01

    This article represents a broad survey of the views of C. G. Jung regarding confession and for giveness. Man, a naturally religious being, has a need to confess his wrong and to gain forgiveness of one sanctioned to absolve. The curative effect of confession has been known for centuries. Without confession, man remains in moral isolation. Priests, ministers, and rabbis, as well as psychotherapists, attest to the universality of this human phenomenon. Confession is located in that place where psychology and religion meet-guilt. Jung's views on confession bridge the chasm between psychology and religion.

  5. [Freud and Jung. Cooperation--break--mutual stimulation].

    Science.gov (United States)

    Falzeder, Ernst

    2011-01-01

    The article tries to throw new light on the Freud/Jung relationship. First, it studies the nature of the fundamental differences between the two theories. Second, it raises the question of what, and how much, each of them took over from the other, and reaches the conclusion that it was Freud who let himself be inspired to a greater degree than Jung did. Third, the stimulating effect of their conflicts and of their break on the respective development of their theories is underlined.

  6. Jung and the Soul of Education (at the "Crunch")

    Science.gov (United States)

    Rowland, Susan

    2012-01-01

    C. G. Jung offers education a unique perspective of the dilemma of collective social demands versus individual needs. Indeed, so radical and profound is his vision of the learning psyche as collectively embedded, that it addresses the current crisis over the demand for utilitarian higher education. Hence post-Jungian educationalists can develop…

  7. Different Strokes for Different Folks: Jung's Typology and Structured Experiences.

    Science.gov (United States)

    Haber, Russell Alan

    1980-01-01

    Examined and compared the evaluations of students differentiated by Carl Jung's psychotypology when they were involved in either a session of nonverbal communication experiences or a session of fantasy experiences. Some of the Jungian psychological types preferred different structured experiences. (Author)

  8. Jung's mediatory science as a psychology beyond objectivism.

    Science.gov (United States)

    Kotsch, W E

    2000-04-01

    In this paper, the author argues that Jung's non-objectivist--yet scientific--epistemology and his empirical/hermeneatic methods of inquiry situate him within a psychological tradition that, in many respects, began with William James and, today, is finding expression in the work of many non-Jungian cognitive scientists. In an effort to encourage dialogue between Jungians and scholars within related intellectual traditions, the author presents evidence from the corpus of Jung's work that demonstrates that, like William James, Jung intentionally rejected the absolutist claims of objectivism and the opposite position on 'anything goes' relativism, emotivism, or subjectivism. Instead, Jung forged a path that led to the meta-psychological position similar to internal realism (Putnam 1981) or experientialism (Lakoff 1987) and to a theoretical psychology that gave a central place both to unconscious cognitive structure and to imagination. This he labelled a 'mediatory science'. The psychological theories developed within this mediatory science framework represent an early articulation of key constructs that are currently used by a number of cognitive scientists seeking to understand how we make sense of experience.

  9. GERMAN JUNG VON MATT ADVERTISING AGENCY%德国JUNG VON MATT广告公司

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    1991年,Holger Jung和Jean—Remy在德国汉堡成立了他们的广告代理所。今天,15年过去了,当初的代理所已发展成为控股公司,在讲德语国家拥有12个分支机构(8个广告公司,4个专卖店)和600名员工。2005年,其在汉堡、斯图加特、柏林、科隆、苏黎士、维也纳和斯德哥尔摩各地公司的营业总额达到3.99亿欧元,这就是Jung von Matt——德国第二大自主经营的本土广告公司。

  10. Measuring heart rate variability by means of information entropies based on Choi-Williams distribution.

    Science.gov (United States)

    Vallverdú, Montserrat; Clariá, Francesc; Melia, Umberto; Bayés de Luna, Antonio; Caminal, Pere

    2015-08-01

    The Shannon entropy theory was applied to the Choi-Williams time-frequency distribution (CWD) of cardiac time series (RR series) in order to extract entropy information in both time and frequency domains. From this distribution, four indexes were defined: (1) instantaneous partial entropy; (2) spectral partial entropy; (3) instantaneous complete entropy; (4) spectral complete entropy. These indexes were used for analyzing the heart rate variability of ischemic cardiomyopathy patients (ICM) with different sudden cardiac death risk. The results have shown that the values of these indexes tend to decrease, with different proportion, when the severity of pathological condition increases. Statistical differences (p-value < 0.0005) of these indexes were found comparing low risk and high risk of cardiac death during night and between daytime and nighttime periods of ICM patients. Finally, these indexes have demonstrated to be useful tools to quantify the different complex components of the cardiac time series.

  11. Jung on the nature and interpretation of dreams: a developmental delineation with cognitive neuroscientific responses.

    Science.gov (United States)

    Zhu, Caifang

    2013-12-01

    Post-Jungians tend to identify Jung's dream theory with the concept of compensation; they tend to believe that Jung's radically open stand constitutes his dream theory in its entirety. However, Jung's theory regarding dreams was a product of an evolving process throughout his whole intellectual and professional life. Unfortunately, the theory has not been understood in such a developmental light. Based on a historical and textual study of all dream articles found throughout The Collected Works of C.G. Jung, this paper maps a concise three-phase trajectory of Jung's changing views on dreams and interpretation. The paper posits that Jung's last essay, "Symbols and the Interpretation of Dreams" (1961), epitomizes his final stand, although such a stand is also reflected in a less explicit and less emphatic way during the latter period of the second phase. The paper also briefly addresses where Jung and Jungians have been enigmatic or negligent. For example, it has not been explicated fully why compensation as slight modifications and compensation as parallels to waking life situations are rare in Jung's cases In addition, contemporary cognitive and neuroscientific approaches to the study of dreams, as represented by Harry Hunt, William Domhoff, and Allan Hobson, among others, are presented in connection with Jung. The juxtaposition of Jungian, cognitive, and neuroscientific approaches showcases how cognitive and scientific findings challenge, enrich, and in some ways confirm Jung's dream theory and praxis.

  12. Existential perspective in the thought of Carl Jung.

    Science.gov (United States)

    Shelburne, W A

    1983-03-01

    It is argued that there is a significant existential perspective in the thought of Carl Jung. Similarities and differences with some of the views of Jean Paul Sartre are explored as a way of developing this perspective and to show how a philosophy of a man might be developed drawing from both sources. Jung is shown to be in disagreement with Sartre in defending an idea of a determinate human nature, describing the self in a developmental way, and in not claiming that human freedom is absolute or unconditioned. Nevertheless, the Jungian concept of individuation is similar to Sartre's ideal of authenticity, in that both focus on the goal of achieving meaningful existence through development of inner resources, creative exercise of freedom, and overcoming self-deception.

  13. Tecnologia dos sonhos em Artemidoro, Freud, Jung e nos Warlpiri

    Directory of Open Access Journals (Sweden)

    Abrahão de Oliveira Santos

    2014-08-01

    Full Text Available Apresentaremos distintas tecnologias dos sonhos: em Artemidoro, Freud, Jung e nos Warlpiri. Artemidoro revela a mensagem onírica imprescindível à condução do cidadão, com os elementos das instituições, da cidade, do cosmo. Com Freud, no moderno mundo europeu, o sonho recebe o sentido da interioridade. Outra leitura é de Carl Jung. O uso dos sonhos tem seu sentido histórico, se relacionando com as práticas de governo, os modos de condução da vida e da cidade. Para além das tradições eurodescendentes e mentalistas vigentes, apresentaremos a tecnologia coletiva dos sonhos dos Warlpiri e uma nova possibilidade de lidarmos com a experiência onírica.

  14. From Moscovici to Jung: the feminine archetype and its iconography

    Directory of Open Access Journals (Sweden)

    Jesús Saiz Galdós

    2007-05-01

    Full Text Available Our representations of women have their origins in the myths of the past. According to Jung, myths are the symbolic expression of the collective unconscious that expresses itself through archetypes. Archetypes are thus images that pass across generations: instruments of collective thought. The main archetypes we deal with in this article are the Mother and the Anima, or men´s feminine principle. Using Jung's concept of archetype to analyse women´s iconographic representations allows us to combine the notion of the collective unconscious with that of social representations. Whereas Moscovici´s theory of social representations offers us the possibility of analysing beliefs about women through history, Jung’s perspective reveals us the possibility of analysing the myths constructed around women as part of the archetypes people use to give sense to reality.

  15. Stereoselective uptake and distribution of the chiral neonicotinoid insecticide, Paichongding, in Chinese pak choi (Brassica campestris ssp. chinenesis)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Haiyan; Yang, Zhen; Liu, Ruyang; Fu, Qiuguo; Zhang, Sufen; Cai, Zhiqiang; Li, Juying; Zhao, Xiaojun [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Ye, Qingfu, E-mail: qfye@zju.edu.cn [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Wang, Wei [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Li, Zhong, E-mail: lizhong@ecust.edu.cn [School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)

    2013-11-15

    Highlights: • Absorption of foliar applied Paichongding by pak choi was not stereoselective. • Foliar uptake and downward transport of Paichongding were both found in pak choi. • Enantioselective and epimer-selective root uptake were observed for Paichongding. • Foliage/root uptake showed diastereoselective transport of Paichongding epimers. • The SR and RS are more easily taken up by roots and accumulated in edible parts. -- Abstract: Neonicotinoid chiral insecticidal Paichongding is a promising substitute for the widely used imidacloprid. Four stereoisomers of Paichongding, 5R,7R, 5S,7S, 5S,7R and 5R,7S, were employed in both foliage and roots of Chinese pak choi to investigate their stereoselective uptake and distribution in pak choi. Results showed that after foliar application, no stereoselective absorption into pak-choi plants was observed among the enantiomers. Total absorptions were 35.40% of the applied amount for 5R,7R, 36.66% for 5S,7S, 36.80% for 5S,7R and 38.20% for 5R,7S at 96 HAT. The translocation of the four absorbed stereoisomers within pak choi occurred both acropetally and basipetally and the transport of {sup 14}C from enantiomers 5R,7R and 5S,7S were significantly higher than for 5R,7S and 5S,7R. Significant stereoselective translocation inside plants was observed between Paichongding epimers. Total root uptake reached 16.49–19.85% for 5R,7R and 5S,7S, and 24.57–28.82% for 5S,7R and 5R,7S at 144 HAT. Both enantioselective and diastereoselective root uptake into pak-choi occurred between the four stereoisomers. The 5R,7S and 5S,7R enantiomers were more readily uptaken by the roots than 5R,7R and 5S,7S and accumulated in the edible leaves. These results will help to develop an understanding of Paichongding using only the target-active enantiomer of pesticides.

  16. Apontamentos sobre a psicologia analítica de Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Luís Marcelo Alves Ramos

    2002-01-01

    Full Text Available O texto faz uma introdução à Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung: define o conceito de Psicologia Analítica, traz uma biografia resumida de Carl Gustav Jung, indica as principais diferenças entre a Psicologia Analítica e a Psicanálise, descreve a estrutura e o funcionamento da psique e, por fim, apresenta sinteticamente as características dos tipos de personalidades traçadas por Jung. The text makes an introduction to the Analytical Psychology of the psychologist and swiss psychiatrist Carl Gustav Jung: it defines the concept of Analytical Psychology, brings a summarized biography of Carl Gustav Jung, indicates the main differences between Analytical Psychology and the Psychoanalysis, describes the structure and the functioning of psyche and, finally, presents synthetically the characteristics of the types of personalities traced by Jung.

  17. Jung Işığında Heba Heba In The Light Of Jung

    Directory of Open Access Journals (Sweden)

    Esra SAZYEK

    2013-09-01

    Full Text Available Hasan Ali Toptaş, is one of the important authors of Turkishliterature, in his novel called Heba discusses inward looking personalityof Ziya, who lives in the same childish purity during his life consistingof all periods of childhood, military service, marriage and death. Due tothis property, he lives world of dreams and fantasies rather than reeltime. 16 years after he lost his wife and unborn son as casualties inbomb attack, Yazıköy where he breaks away from the crowd of the cityand settle in here, feeds his this side. Thus, the hours passing in thenature, turn into a worship. However, whole peace of Ziya, who hasfound what he seeks in Yazıköy, ends by killing of Kenan. This periodwhen everything has became complicated, is followed by killing of himas being lynched because of the gossips about him.When you reread the novel focusing on a wasted life, of whichtragic events are finished by death in the light of Jungian psychology, itturns into a story of award to reach immortality obtained after thesorrows felt.Experiences of Ziya in Yazıköy resembling Heaven until he isdismissed, realize on the cusp of a magical environment is surroundedby dreams and fantasies. Appearance of unconscious plane by means ofsymbolical contents in dreams indicates that Yazıköy representsunconscious world beyond being a geographic and travelling from thecity to natural follows a way from conscious towards unconscious.Exploring of Ziya moving in unknown darkness of unconsciousthe inner treasure in the deepest, requires passing the each phase fromsurface towards center with a different figure of unconscious named as"archetype" by Jung.In this study, dimensions of period in question will be discussedin terms of Jungian psychology; trails of his thoughts will be examinedin detail by its aspects are reflected on contextual dimension of thenovel. Türk edebiyatının önemli yazarlarından olan Hasan Ali Toptaş, Heba adlı romanında çocukluk, askerlik, evlilik

  18. HS0139+0559, HS0229+8016, HS0506+7725 and HS0642+5049: Four new long-period cataclysmic variables

    CERN Document Server

    Aungwerojwit, A; Rodríguez-Gil, P; Hagen, H J; Harlaftis, E T; Papadimitriou, C; Lehto, H; Araújo-Betancor, S; Heber, U; Fried, R E; Engels, D; Katajainen, S

    2005-01-01

    We present time-resolved optical spectroscopy and photometry of four relatively bright (V~14.0-15.5) long-period cataclysmic variables (CVs) discovered in the Hamburg Quasar Survey: HS0139+0559, HS0229+8016, HS0506+7725 and HS0642+5049. Their respective orbital periods, 243.69+-0.49min, 232.550+-0.049min, 212.7+-0.2min and 225.90+-0.23min are determined from radial velocity and photometric variability studies. HS0506+7725 is characterised by strong Balmer and He emission lines, short-period (~10-20min) flickering and weak X-ray emission in the ROSAT All Sky Survey. The detection of a deep low state (~18.5) identifies HS0506+7725 as a member of the VY Scl stars. HS0139+0559, HS0229+8016 and HS0642+5049 display thick-disc like spectra and no or only weak flickering activity. HS0139+0559 and HS0229+8016 exhibit clean quasi-sinusoidal radial velocity varations of their emission lines but no or very little orbital photometric variability. In contrast, we detect no radial velocity variation in HS0642+5049 but a not...

  19. Analytical psychology and the ghost of Lamarck: did Jung believe in the inheritance of acquired characteristics?

    Science.gov (United States)

    Rensma, Ritske

    2013-04-01

    Whether Jung was a Lamarckian or not has always been a hotly debated topic, both within the post-Jungian community and amongst scholars with an interest in Jung in the wider academic community. Yet surprisingly few substantial pieces of work have been dedicated to it and, to my mind, no one has yet managed to do justice to all the subtleties involved. The scholars who have claimed that Jung is a Lamarckian have, for the most part, oversimplified the debate by failing to discuss the passages in which Jung appears to be defending himself against Lamarckism; the scholars who have defended Jung against Lamarckism, however, have as a rule not adequately dealt with the question of whether these passages actually get Jung off the hook. This paper will attempt to correct this imbalance by putting forward four key passages spanning Jung's career that all represent conclusive evidence that Jung was indeed a Lamarckian. After discussing these, it will then deal in detail with the passages in which Jung appears to be defending himself against Lamarckism, making the case that they do not represent a defence against Lamarckism at all and have therefore generally been misinterpreted by many scholars.

  20. Tender love and transference: unpublished letters of C. G. Jung and Sabina Spielrein.

    Science.gov (United States)

    Lothane, Z

    1999-12-01

    The author dissents from the widely accepted interpretation that the relationship between Sabina Spielrein and Carl Jung in the years 1904-1910 included sexual intercourse and constituted an ethical breach of the doctor-patient boundary in the course of a treatment. Spielrein declared that her treatment ended with her discharge from the Burghölzli hospital as Jung's patient in 1904-1905. Jung maintained he 'prolonged the relationship' in order to prevent a relapse and also referred to it as a friendship. Materials published in 1994 (letters, drafts, diaries, hospital chart) and unpublished letters recently found by the author in the Claparède archive in Geneva shed new light on previously published documents and interpretations by Carotenuto that have dominated the secondary literature since 1980. The new materials provide a more nuanced view of the Spielrein-Jung relationship and point to the function of non-erotic love in the therapeutic relationship. A new look at the Freud-Jung correspondence about the Spielrein-Jung relationship shows that Jung's perception that a sex scandal was initiated by Spielrein resulted from Jung's misreading of rumors concerning another woman; the episode had no ill effect on the relationship between Freud and Jung.

  1. Requiem for analytical psychology: a reflection on Jung's (anti)catastrophic psychology.

    Science.gov (United States)

    Barreto, Marco Heleno

    2014-02-01

    This article is an interpretation of analytical psychology in the light of the catastrophic vision and dreams that Jung had in 1913 and 1914. It is shown how the guiding spirit of Jung's psychological project is to be found in that psychic material. Then it is proposed that the completion of the symbolic catastrophe displayed in Jung's last vision (1961) points to the end of the psychological foundations upon which analytical psychology is built, and thus to its cultural obsolescence, extensive to any psychology grounded in Jung's notion of 'soul'.

  2. Effects of Amino Acids Replacing Nitrate on Growth, Nitrate Accumulation, and Macroelement Concentrations in Pak-choi (Brassica chinensis L.)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A hydroponic experiment was carried out to determine the influence of replacing 20% of nitrate-N in nutrient solutions with 20 individual amino acids on growth, nitrate accumulation, and concentrations of nitrogen (N), phosphorus (P), and potassium (K) in pak-choi (Brassica chinensis L.) shoots. When 20% of nitrate-N was replaced with arginine (Arg)compared to the full nitrate treatment, pak-choi shoot fresh and dry weights increased significantly (P ≤ 0.05), but when 20% of nitrate-N was replaced with alanine (Ala), valine (Val), leucine (Leu), isoleucine (Ile), proline (Pro), phenylalanine (Phe), methionine (Met), aspartic acid (Asp), glutamic acid (Glu), lysine (Lys), glycine (Gly), serine (Ser), threonine(Thr), cysteine (Cys), and tyrosine (Tyr), shoot fresh and dry weights decreased significantly (P ≤ 0.05). After replacing 20% of nitrate-N with asparagine (Asn) and glutamine (Gln), shoot fresh and dry weights were unaffected. Compared to the full nitrate treatment, amino acid replacement treatments, except for Cys, Gly, histidine (His), and Arg, significantly reduced (P ≤ 0.05) nitrate concentrations in plant shoots. Except for Cys, Leu, Pro, and Met, total N concentrations in plant tissues of the other amino acid treatments significantly increased (P ≤ 0.05). Amino acids also affected total P and K concentrations, but the effects differed depending on individual amino acids. To improve pak-choi shoot quality, Gln and Asn, due to their insignificant effects on pak-choi growth, their significant reduction in nitrate concentrations, and their increase in macroelement content in plants, may be used to partially replace nitrate-N.

  3. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    Science.gov (United States)

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl Jung was…

  4. C.G. Jung come precursore di una filosofia per l'anima

    OpenAIRE

    Madera, R.

    2007-01-01

    In una delle accezioni di filosofia per Jung è contenuta una idea della filosofia come modo di vivere: questa intuizione fa di Jung un precursore della riscoperta della filosofia come stile di vita e, insieme, trasforma la psicologia analitica in un primo passo per la riapertura di una via sapienziale propria dell'Occidente

  5. Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group by Methyl Jasmonate

    Directory of Open Access Journals (Sweden)

    Moo Jung Kim

    2017-05-01

    Full Text Available Glucosinolates, their hydrolysis products and primary metabolites were analyzed in five pak choi cultivars to determine the effect of methyl jasmonate (MeJA on metabolite flux from primary metabolites to glucosinolates and their hydrolysis products. Among detected glucosinolates (total 14 glucosinolates; 9 aliphatic, 4 indole and 1 aromatic glucosinolates, indole glucosinolate concentrations (153–229% and their hydrolysis products increased with MeJA treatment. Changes in the total isothiocyanates by MeJA were associated with epithiospecifier protein activity estimated as nitrile formation. Goitrin, a goitrogenic compound, significantly decreased by MeJA treatment in all cultivars. Changes in glucosinolates, especially aliphatic, significantly differed among cultivars. Primary metabolites including amino acids, organic acids and sugars also changed with MeJA treatment in a cultivar-specific manner. A decreased sugar level suggests that they might be a carbon source for secondary metabolite biosynthesis in MeJA-treated pak choi. The result of the present study suggests that MeJA can be an effective agent to elevate indole glucosinolates and their hydrolysis products and to reduce a goitrogenic compound in pak choi. The total glucosinolate concentration was the highest in “Chinese cabbage” in the control group (32.5 µmol/g DW, but indole glucosinolates increased the greatest in “Asian” when treated with MeJA.

  6. On defining words, some scenarios and vectors in the 'autobiography' of C. G. Jung.

    Science.gov (United States)

    Gaillard, Christian

    2003-11-01

    Having first considered recent research into the circumstances surrounding the production and publication of the 'autobiography' of Jung, the author concludes that in spite of its being the work of several authors, it nevertheless constitutes a whole. Taken from whichever angle, they all point to Jung's particular inquiry into the unconscious, as it emerges through Jung's own words. The author goes on to suggest both a lateral and a structural reading of MDR (Memories, Dreams, Reflections) which in turn reveals, on the basis of the several dreams reported, the central 'fantasy' which inspired Jung's research and his oeuvre. Finally, he discusses the idea of the collective or impersonal unconscious and highlights the emphasis Jung places on processes which unfold according to rhythms which are associated with distinct scales, depending on whether they are those of the individual, the clan or the culture.

  7. O conceito de religiosidade em C. G. Jung

    Directory of Open Access Journals (Sweden)

    Xavier, Marlon

    2006-01-01

    Full Text Available O artigo procura descrever o conceito de religiosidade na psicologia junguiana, conectando-o aos conceitos que embasam e se relacionam com sua especificidade, contextualizando-o de forma breve no panorama científico atual e relacionando-o à prática psicoterapêutica. Para tanto, utiliza as obras de Jung e de autores relacionados com a temática abordada. O estudo suscitou questionamentos em relação à importância dada à consideração e ao estudo do fator religiosidade em psicologia e na prática clínica. Conclui-se que a religiosidade é fator de suma importância no entendimento do humano e conseqüêntemente na prática clínica, sendo que a teoria de Jung fornece elementos que possibilitam um estudo e uma compreensão em profundidade desse fator

  8. Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, N., E-mail: Nicolai.schramm@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Englhart, E., E-mail: Elisabeth.Englhart@gmx.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Schlemmer, M., E-mail: Marcus.Schlemmer@med.uni-muenchen.de [Department of Medicine III, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Hittinger, M., E-mail: Markus.Hittinger@uksh.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Übleis, C., E-mail: Christopher.Uebleis@med.uni-muenchen.de [Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Becker, C.R., E-mail: Christoph.becker@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Reiser, M.F., E-mail: Maximilian.Reiser@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Berger, F., E-mail: Frank.Berger@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany)

    2013-06-15

    Purpose: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). Patients and methods: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan–Meier statistics. Results: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. Conclusion: One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.

  9. Rare earth elements in suspended and bottom sediments of the Mandovi estuary,central west coast of India: Influence of mining

    Digital Repository Service at National Institute of Oceanography (India)

    Shynu, R.; Rao, V.P.; Kessarkar, P.M.; Rao, T.G.

    -868. Vijith, V., Sundar, D., Shetye, S. R., 2009. Time-dependence of salinity in monsoonal estuaries. Estuarine, Coastal and Shelf Science 85, 601-608. Yang, S.Y., Jung, H.S., Choi, M.S., Li, C.X., 2002. The rare earth element compositions...

  10. Distribution and fractionation of rare earth elements and Yttrium in suspended and bottom sediments of the Kali estuary, western India

    Digital Repository Service at National Institute of Oceanography (India)

    Suja, S.; Fernandes, L.L.; Rao, V.P.

    around the Yellow Sea: implications for sediment provenance. Geo-Marine Lett 29: 291-300. Yang SY, Jung HS, Choi MS, Li CX (2002) The rare earth element compositions of the Changjiang (Yangtze) and Huanghe (Yellow) river sediments. Earth Planet Sci...

  11. FREUD, JUNG AND BOAS: THE PSYCHOANALYTIC ENGAGEMENT WITH ANTHROPOLOGY REVISITED.

    Science.gov (United States)

    Kenny, Robert

    2015-06-20

    Sigmund Freud's and C. G. Jung's turn to evolutionist anthropological material after 1909 is usually seen as a logical progression of their long-term interest in such material. It is also seen that they used this material ignorant of the significant challenges to the evolutionist paradigm underpinning such material, in particular the challenges led by Franz Boas. This paper argues otherwise: that both psychologists' turnings to such material was a new development, that neither had shown great interest in such material before 1909, and that their turnings to such material, far from being taken in ignorance of the challenges to evolutionist anthropology, were engagements with those challenges, because the evolutionist paradigm lay at the base of psychoanalysis. It argues that it is no coincidence that this engagement occurred after their return from America in 1909, where they had come into first-hand contact with the challenges of Franz Boas.

  12. Freud, Jung and Boas: the psychoanalytic engagement with anthropology revisited

    Science.gov (United States)

    Kenny, Robert

    2015-01-01

    Sigmund Freud's and C. G. Jung's turn to evolutionist anthropological material after 1909 is usually seen as a logical progression of their long-term interest in such material. It is also seen that they used this material ignorant of the significant challenges to the evolutionist paradigm underpinning such material, in particular the challenges led by Franz Boas. This paper argues otherwise: that both psychologists' turnings to such material was a new development, that neither had shown great interest in such material before 1909, and that their turnings to such material, far from being taken in ignorance of the challenges to evolutionist anthropology, were engagements with those challenges, because the evolutionist paradigm lay at the base of psychoanalysis. It argues that it is no coincidence that this engagement occurred after their return from America in 1909, where they had come into first-hand contact with the challenges of Franz Boas. PMID:26665301

  13. 'S.W.' and C.G. Jung: mediumship, psychiatry and serial exemplarity.

    Science.gov (United States)

    Shamdasani, Sonu

    2015-09-01

    On the basis of unpublished materials, this essay reconstructs Jung's seances with his cousin, Helene Preiswerk, which formed the basis of his 1902 medical dissertation, The Psychology and Pathology of so-called Occult Phenomena. It separates out Jung's contemporaneous approach to the mediumistic phenomena she exhibited from his subsequent sceptical psychological reworking of the case. It traces the reception of the work and its significance for his own self-experimentation from 1913 onwards. Finally, it reconstructs the manner in which Jung continually returned to his first model and reframed it as an exemplar of his developing theories.

  14. Atom and archetype the Pauli/Jung letters, 1932-1958

    CERN Document Server

    2001-01-01

    Wolfgang Pauli, world-renowned physicist, turned to Carl Jung for help, setting a standing appointment for Mondays at noon. Thus bloomed an extraordinary intellectual conjunction. Eighty letters, written over twenty-six years, record that friendship, and are published here in English for the first time.Through the association of these two pioneering thinkers, developments in physics profoundly influenced the evolution of Jungian psychology. And many of Jung's abiding themes shaped how Pauli - and, through him, other physicists - understood the physical world. Atom and Archetype will appeal not only to those interested in the life of Pauli or Jung, but also to the educated general reader.

  15. Apontamentos sobre a psicologia analítica de Carl Gustav Jung

    OpenAIRE

    Luís Marcelo Alves Ramos

    2002-01-01

    O texto faz uma introdução à Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung: define o conceito de Psicologia Analítica, traz uma biografia resumida de Carl Gustav Jung, indica as principais diferenças entre a Psicologia Analítica e a Psicanálise, descreve a estrutura e o funcionamento da psique e, por fim, apresenta sinteticamente as características dos tipos de personalidades traçadas por Jung. The text makes an introduction to the Analytical Psychology of the psycholo...

  16. [Carl Gustav Jung's Theatrum Mundi. Can the description of modern alchemy in Jung's Psychologie und Alchemie be really regarded as a historical reconstruction?].

    Science.gov (United States)

    Płonka-Syroka, B

    2000-01-01

    In his work, Psychologie und Alchemie, published in 1944, Jung wanted to present a reconstruction of alchemy. In order to do this he used a method of psychology, which he modified and enriched with inspirations drawn from neo-romantically-oriented German medical historiographies of the nineteen thirties. Using historical materials, he intended to demonstrate the empirical character of his Depth Psychology, a widespread concept, ingrained in our supra-personal social unconscious. The present article questions the nature of Jung's reconstruction of alchemy as historical reconstruction. The author presents the methodological bases referred to by Jung derived from his concept of medical practice and compares them with a manner of thinking typical of contemporary historical analysis. The article also presents Jung's inspirations from the medical historiography of his time, as well as the dissimilarity of his concept with the model of historical narrative construction in force in the historiography of the thirties and forties. At the same time, it presents the elements of the "romantic inheritance" in Jung's thought, drawn from the tradition of German non-materialistic medicine of the first half of the nineteenth century.

  17. Italian Validation of Homophobia Scale (HS

    Directory of Open Access Journals (Sweden)

    Giacomo Ciocca, PsyD, PhD

    2015-09-01

    Conclusions: The Italian validation of the HS revealed the use of this self‐report test to have good psychometric properties. This study offers a new tool to assess homophobia. In this regard, the HS can be introduced into the clinical praxis and into programs for the prevention of homophobic behavior. Ciocca G, Capuano N, Tuziak B, Mollaioli D, Limoncin E, Valsecchi D, Carosa E, Gravina GL, Gianfrilli D, Lenzi A, and Jannini EA. Italian validation of Homophobia Scale (HS. Sex Med 2015;3:213–218.

  18. Interlocução entre Rudolf Otto, Carl Gustav Jung e Victor White

    Directory of Open Access Journals (Sweden)

    Rodrigo Pereira Ceccon

    2012-04-01

    Full Text Available In 1917 Rudolf Otto published the book The Sacred and proposing the recognition of the irrational aspect as the foundation and maintainer of religious expression by means of analogies and antonyms that the called the numinous. Later, at a conference in1937, Carl Gustav Jung uses the term numinous to clarify what he meant by religion, recognizing this as an observation on what grabs consciousness, thus extending the idea of the numinous to practice and clinical studies. Victor White, Jung's main collaborator in the field of theology, weaves a critical to Otto and Jung's position front to the understanding of religious phenomena, stating that it presents a unilateralism in recognition that only their irrational sphere supports religion. This article aims to lead to a theoretical discussion as to White's reflections on the idea of numinous, in contrast to the positions of Otto and Jung.

  19. Verification of C. G. Jung's analysis of Rowland Hazard and the history of Alcoholics Anonymous.

    Science.gov (United States)

    Bluhm, Amy Colwell

    2006-11-01

    Extant historical scholarship in the Jungian literature and the Alcoholics Anonymous (AA) literature does not provide a complete picture of the treatment of Rowland Hazard by C. G. Jung, an analysis that AA co-founder Bill Wilson claimed was integral to the foundation of AA in theory and practice. Wilson's original report resulted in archivists and historians incorrectly calibrating their searches to the wrong date. The current work definitively solves the mystery of the timing of Hazard's treatment with Jung by placing his preliminary analysis with Jung in the year 1926, rather than 1930 or 1931. Previously unexamined correspondence originating from Jung, Hazard, his cousin Leonard Bacon, his uncle Irving Fisher, and his aunt Margaret Hazard Fisher is supplemented by relevant primary and secondary source material.

  20. Análise de crescimento e produtividade do pak choi cultivado sob diferentes doses de nitrogênio

    Directory of Open Access Journals (Sweden)

    Janaína Dartora

    2013-08-01

    Full Text Available O objetivo deste trabalho foi avaliar a influência de diferentes doses de nitrogênio no crescimento e produtividade do pak choi. O experimento foi conduzido, em cultivo protegido, de outubro a novembro de 2007, em Marechal Cândido Rondon, PR. O delineamento experimental foi de blocos casualizados, com cinco tratamentos (0, 60, 105, 150 e 195 kg ha-1 de N e quatro repetições. O nitrogênio foi aplicado em três diferentes épocas (transplantio, 7 e 14 dias após o transplantio. Foram realizadas cinco coletas das plantas, semanalmente, avaliando-se a produção de massa da matéria seca e área foliar, para obtenção das taxas de crescimento absoluto e relativo, taxa assimilatória líquida, razão de área foliar e área foliar específica. Na colheita, foram avaliados altura da planta, diâmetro e matéria fresca da parte aérea e produtividade. Incrementos na adubação nitrogenada até a dose de 195 kg ha-1 proporcionam incrementos no crescimento e produtividade do pak choi.

  1. Variation in glucosinolates in pak choi cultivars and various organs at different stages of vegetative growth during the harvest period

    Institute of Scientific and Technical Information of China (English)

    Biao ZHU; Jing YANG; Zhu-jun ZHU

    2013-01-01

    Glucosinolates (GSs) play an important role in plant defense systems and human nutrition.We investigated the content and composition of GSs in the shoots and roots of seven cultivars of pak choi.We found that ‘Si Yue Man’ had the highest total and aliphatic GS contents in the shoots and the highest benzenic GS content in the roots,‘Shanghai Qing’ contained the highest amounts of benzenic and total GS contents in the roots,while ‘Nanjing Zhong Gan Bai’ had the lowest benzenic,indole,and total GS contents in both the shoots and roots.Therefore,the ‘Si Yue Man’ cultivar appears to be a good candidate for future breeding.Variation between the shoots and roots was also examined,and a significant correlation among the total,aliphatic,and some individual GSs was found,which is of value in agricultural breeding.GS concentrations of the leaf,petiole,and root increased dramatically during the period of rapid growth of the dry matter of the plant 10 to 20 d after transplantation,reaching peak values on Day 20 and decreasing on Day 25.We conclude that the pak choi should be harvested and consumed from 20 to 25 d after transplantation to take advantages of the high GS content in the plant.

  2. A psicologia analítica de Carl Gustav Jung: apontamentos de aula/The analytical psychology of Carl Gustav Jung: notes of lesson

    Directory of Open Access Journals (Sweden)

    Luís Marcelo Alves Ramos

    2005-01-01

    Full Text Available O texto traz o conteúdo de uma aula sobre Teorias da Personalidade com foco nos fundamentos da Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung (1875-1961, cuja obra vem apresentando significativas contribuições para a Psicologia Educacional, Organizacional e Clínica. The text brings the content of a lesson on Theories of Personality focused in the fundamentals of the Analytical Psychology of the Swiss psychologist and psychiatrist Carl Gustav Jung (1875-1961, whose work has been presenting significant contributions for Educational, Organizational and Clinical Psychology.

  3. A collective unconscious reconsidered: Jung's archetypal imagination in the light of contemporary psychology and social science.

    Science.gov (United States)

    Hunt, Harry T

    2012-02-01

    A needed rapprochement between Jung and the contemporary human sciences may rest less on the much debated relevance of a biologistic collective unconscious than on a re-inscribing of an archetypal imagination, as the phenomenological and empirical core of Jungian psychology. The most promising approaches in this regard in terms of theory and research in psychology come from combining the cognitive psychology of metaphor and synaesthesia, individual differences in imaginative absorption and openness to numinous experience and spirituality as a form of symbolic intelligence. On the socio-cultural side, this cognitive psychology of archetypal imagination is also congruent with Lévi-Strauss on the metaphoric roots of mythological thinking, and Durkheim on a sociology of collective consciousness. This conjoined perspective, while validating the cross cultural commonality of physical metaphor intuited by Jung and Hillman on alchemy, also shows Jung's Red Book, considered as the expressive source for his more formal psychology, to be far closer in spirit to a socio-cultural collective consciousness, based on metaphoric imagination, than to a phylogenetic or evolutionary unconscious. A mutual re-inscribing of Jung into congruent areas of contemporary psychology, anthropology, sociology, and vice versa, can help to further validate Jung's key observations and is fully consistent with Jung's own early efforts at synthesis within the human sciences. © 2012, The Society of Analytical Psychology.

  4. Beyond synchronicity: the worldview of Carl Gustav Jung and Wolfgang Pauli.

    Science.gov (United States)

    Donati, Marialuisa

    2004-11-01

    While exploring the phenomena of synchronicity, Carl Gustav Jung became acquainted with the quantum physicist Wolfgang Pauli and eventually began a collaboration with him. During that collaboration Jung's study of synchronistic phenomena underwent a considerable change; prior to the collaboration, Jung had stressed mainly the phenomenological and empirical features of synchronistic phenomena, while in association with Pauli, he focused his attention upon their ontological, archetypal character. Pauli, on the other hand, became increasingly sensitive to the philosophical aspects concerning the unconscious. Jung and Pauli's common reflections went far beyond psychology and physics, entering into the realm where the two areas meet in the philosophy of nature. In fact, as a consequence of their collaboration, synchronicity was transformed from an empirical concept into a fundamental explanatory-interpretative principle, which together with causality could possibly lead to a more complete worldview. Exploring the problematic character of the synchronicity concept has a heuristic value because it leads to the reconsideration of the philosophical issues that drove Jung and Pauli to clear up the conceptual background of their thoughts. Within the philosophical worldview arising from Jung and Pauli's discussions about synchronicity, there are many symbolic aspects that go against mainstream science and that represent a sort of criticism to some of the commonly held views of present day science.

  5. Se Faire Voir with Jung and the Ethics of Psychoanalysis

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    Matthew Gildersleeve

    2017-02-01

    Full Text Available This article is an important addition to my previous work of integrating Jungian and Lacanian psychoanalysis (see Complexes Tickling the $ubject. A main focus of this article is to use Zizek’s interpretation of Lacan’s writing on desire and drive in relation to my Heideggerian interpretation of Jung. As a result, this article is an important contribution to the literature because it shows the importance of the transcendent function; complexes and the Rosarium Philosophorum to elucidate the ethics of desire and drive. This article shows how Heidegger’s work in Being and Time and his interpretation of Nietzsche is important to detail the process of Lacanian psychoanalysis. Nietzsche’s books; Human All Too Human and The Gay Science will also be discussed as well as Sartre’s Being and Nothingness and Zizek’s writing on the cunning of reason; Kantian ethics; beyond the pleasure principle; Kierkegaard; Sisyphus; anxiety; Hitchcock; Gelassenheit; the Gospel of Matthew and error as a fundamental passage to truth.

  6. Italian Validation of Homophobia Scale (HS).

    Science.gov (United States)

    Ciocca, Giacomo; Capuano, Nicolina; Tuziak, Bogdan; Mollaioli, Daniele; Limoncin, Erika; Valsecchi, Diana; Carosa, Eleonora; Gravina, Giovanni L; Gianfrilli, Daniele; Lenzi, Andrea; Jannini, Emmanuele A

    2015-09-01

    The Homophobia Scale (HS) is a valid tool to assess homophobia. This test is self-reporting, composed of 25 items, which assesses a total score and three factors linked to homophobia: behavior/negative affect, affect/behavioral aggression, and negative cognition. The aim of this study was to validate the HS in the Italian context. An Italian translation of the HS was carried out by two bilingual people, after which an English native translated the test back into the English language. A psychologist and sexologist checked the translated items from a clinical point of view. We recruited 100 subjects aged18-65 for the Italian validation of the HS. The Pearson coefficient and Cronbach's α coefficient were performed to test the test-retest reliability and internal consistency. A sociodemographic questionnaire including the main information as age, geographic distribution, partnership status, education, religious orientation, and sex orientation was administrated together with the translated version of HS. The analysis of the internal consistency showed an overall Cronbach's α coefficient of 0.92. In the four domains, the Cronbach's α coefficient was 0.90 in behavior/negative affect, 0.94 in affect/behavioral aggression, and 0.92 in negative cognition, whereas in the total score was 0.86. The test-retest reliability showed the following results: the HS total score was r = 0.93 (P homophobia. In this regard, the HS can be introduced into the clinical praxis and into programs for the prevention of homophobic behavior.

  7. Muusikamaailm : "Represseeritud muusika" Moskvas. György Kurtagi festival Londonis. Junge Deutshe Philarmonie kevad. Herbert Wernicke lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Moskvas toimuvast festivalist "Represseeritud muusika". Londonis toimuvast György Kurtagi festivalist. Saksa orkestri Junge Deutshe Philarmonie kevadesinemistest. Suri saksa ooperilavastaja Herbert Wernicke

  8. Muusikamaailm : "Represseeritud muusika" Moskvas. György Kurtagi festival Londonis. Junge Deutshe Philarmonie kevad. Herbert Wernicke lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Moskvas toimuvast festivalist "Represseeritud muusika". Londonis toimuvast György Kurtagi festivalist. Saksa orkestri Junge Deutshe Philarmonie kevadesinemistest. Suri saksa ooperilavastaja Herbert Wernicke

  9. Triniti daripada Perspektif Taoisme: Analisis Pemikiran Jung Young Lee

    Directory of Open Access Journals (Sweden)

    ZURAIZA HUSIN

    2016-06-01

    Full Text Available Jung Young Lee is a Korean-born theologian who employs creatively the doctrine of the Trinity from an Asian worldview. This article aims to analyze Lee’s approaches of the Trinity with the Yin-Yang symbolism. The main reference is based on the book written by him entitled ‘The Trinity in Asian Perspective (1996’. Lee has turned his attention to the topic of Trinity through the lens of the culture and thought patterns of his own milieu. One of the leading point in presenting Yin-Yang principle as Trinitarian thinking, Lee examines the interpretation of the term “in” in the Bible, "Believe me that I am in the Father and the Father is in me" (John 14:11. The statement leads to the point that Yin and Yang cannot exist without each other because relationality is given priority than individuality. The idea is based on the terminology of ‘both/and’. So, ‘and’ indicates a Trinitarian statement, there is interdependence and unification. With reference to Trinity, the Father and the Son are One because of ‘and’. In addition, the same concept implements to the Holy Spirit. Lee views ‘and’ is not only a linking principle in both-and thinking but also the principle that is ‘between’ two. When ‘two’ exists, the third also exist between them. Based on the idea of ‘middle’, represents the connecting element between two, which contributes for the existence of the Third. Accordingly, the Spirit is the third element in the Trinity relationship.

  10. Ordem e subversão no movimento psicanalítico: o fantasma de Jung

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    Michel Plon

    2002-12-01

    Full Text Available O autor procura destacar a presença de Jung na correspondência de Freud com os principais discípulos, no contexto histórico da constituição do movimento psicanalítico e no desdobramento mais importante do mesmo. Vale dizer, a figura de Jung como fantasma no discurso psicanalítico se articula com uma série de problemáticas não apenas teóricas, mas também políticas e institucionais, de maneira que as ressonâncias atuais desta polêmica continuam ainda presentes na psicanálise contemporânea.Jung's ghost. The author tries to highlight Jung's presence in the mail exchange with his main disciples, in the historic context of the constitution of the psychoanalytic movement and in its most important unfolding. It should be said that the figure of Jung as a ghost in the psychoanalytic discourse is articulated with a number of problems that are not only theoretical, but also political and institutional, so that the current repercussions of that polemic remain.

  11. Jung's evolving views of Nazi Germany: from 1936 to the end of World War II.

    Science.gov (United States)

    Schoenl, William

    2014-04-01

    This article first shows Jung's evolving views of Nazi Germany from 1936 to the beginning of World War II. In a lecture at the Tavistock Clinic, London, in October 1936, he made his strongest and most negative statements to that date about Nazi Germany. While in Berlin in September 1937 for lectures to the Jung Gesellschaft, his observations of Hitler at a military parade led him to conclude that should the catastrophe of war come it would be far more and bloodier than he had previously supposed. After the Sudetenland Crisis in Fall 1938, Jung in interviews made stronger comments on Hitler and Nazi Germany. The article shows how strongly anti-Nazi Jung's views were in relation to events during World War II such as Nazi Germany's invasion of Poland, the fall of France, the bombings of Britain, the U.S. entry into the War, and Allied troops advancing into Germany. Schoenl and Peck, 'An Answer to the Question: Was Jung, for a Time, a "Nazi Sympathizer" or Not?' (2012) demonstrated how his views of Nazi Germany changed from 1933 to March 1936. The present article shows how his views evolved from 1936 to the War's end in 1945.

  12. Some reflections on the influence of Chinese thought on Jung and his psychological theory.

    Science.gov (United States)

    Stein, Murray

    2005-04-01

    Jung claimed that Richard Wilhelm, whose masterful translations of Chinese wisdom literature into a European language (German) and thence into Western consciousness have brought Chinese modes of thinking to so many, was one of the most important influences on his own life and work. The contacts between the two men, which took place from the early 1920's until Wilhelm's death in 1930, were few but intense and for Jung decisive in several ways. Wilhelm's translations of the I Ching and The Secret of the Golden Flower opened new avenues for Jung that had far-reaching consequences on his research and writing after 1930. The latter opened the door to the study of alchemy as a key to the archetypal process of individuation as rooted in the collective unconscious. 'Synchronicity' is a term that grew out of his contact with Chinese thought, in particular with the I Ching. From his contact with Chinese thought, additionally, he received confirmation of the view, independently arrived at, that adult psychological development is not linear but rather circular and spiral-like. The letters between Jung and Wilhelm illuminate the great importance Jung ascribed to Wilhelm's contribution toward bridging East and West and the potential value of Chinese philosophy for psychotherapy.

  13. The place of the 17th century in Jung's encounter with China.

    Science.gov (United States)

    Cambray, Joe

    2005-04-01

    After recounting several dreams and related alchemical interests of Jung's tied to the 17(th) century, a contextualizing look at select scientific and philosophical developments of that century is presented. Several precursors of the contemporary debates on the mind/body relation are noted, with special reference to the work of Antonio Damasio. This in turn leads to a reconsideration of the work of the 17(th) century polymath Gottfried Wilhelm Leibniz, which Jung read as a major precursor to his formulation of synchronicity (via Leibniz's concept of 'pre-established harmony'). Leibniz was the first philosopher to articulate the mind/body relationship in terms of supervenience, sharing an accord with those contemporary philosophers and scientists who see the mind as being an emergent property of the body-brain. Similarly, these ideas are also consistent with a reformulation of synchronicity in terms of emergence. Tracing Leibniz's interest in China reveals another set of links to Jung and to emergentism. Jung's use of Taoist concepts in developing the synchronicity principle is well known. According to scholars, Leibniz was the first major Western intellect to study the I-Ching, through the assistance of a Jesuit missionary in Beijing, Fr. Joachim Bouvet. Some details of the Leibniz-Bouvet correspondence are discussed here. Despite Helmut Wilhelm's presenting aspects of this correspondence at an Eranos conference, Jung does not appear to have integrated it into his writing on synchronicity--a possible reason for this omission is suggested.

  14. HS06 Benchmark for an ARM Server

    Science.gov (United States)

    Kluth, Stefan

    2014-06-01

    We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.

  15. HS06 Benchmark for an ARM Server

    CERN Document Server

    Kluth, Stefan

    2013-01-01

    We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.

  16. Glucosinolate Accumulation and Related Gene Expression in Pak Choi (Brassica rapa L. ssp. chinensis var. communis [N. Tsen & S.H. Lee] Hanelt) in Response to Insecticide Application.

    Science.gov (United States)

    Zhu, Biao; Yang, Jing; He, Yong; Zang, Yunxiang; Zhu, Zhujun

    2015-11-11

    Glucosinolates and their breakdown products are well-known for their cancer-chemoprotective functions and biocidal activities against pathogens and generalist herbivores. Insecticides are commonly used in the production of pak choi (Brassica rapa L. ssp. chinensis var. communis [N. Tsen & S.H. Lee] Hanelt). We studied the effects of four commonly used insecticides, namely, β-cypermethrin, acephate, pymetrozine, and imidacloprid, on glucosinolate metabolism in pak choi. All insecticides significantly increased both the transcription of glucosinolate biosynthetic genes and the aliphatic and total glucosinolate accumulations in pak choi. β-Cypermethrin and acephate caused gradual and continuous up-regulation of gene expression from 0.5 to 24 h after treatment, whereas pymetrozine and imidacloprid did so more rapidly, reaching a peak at 1 h and returning to normal at 3 h. Our findings indicate that the four insecticides affect glucosinolate metabolism in pak choi plants to various degrees and suggest that glucosinolates may be involved in plant insecticide metabolism.

  17. Standing in the gap: ref lections on translating the Jung-Neumann correspondence.

    Science.gov (United States)

    McCartney, Heather

    2016-04-01

    This paper considers the experience of translating the correspondence between C.G. Jung and Erich Neumann as part of the Philemon series. The translator explores the similarities between analytical work and the task of translation by means of the concepts of the dialectical third and the interactional field. The history and politics of the translation of analytic writing and their consequences for the lingua franca of analysis are discussed. Key themes within the correspondence are outlined, including Jung and Neumann's pre-war exploration of Judaism and the unconscious, the post-war difficulties around the publication of Neumann's Depth Psychology and a New Ethic set against the early years of the C.G. Jung Institute in Zurich, and the development of the correspondents' relationship over time.

  18. Coincidence, historical repetition, and self-knowledge: Jung, Vico, and Joyce.

    Science.gov (United States)

    Verene, Donald Phillip

    2002-07-01

    Jung develops synchronicity as an a causal principle of connection by recounting various examples of meaningful coincidence from experience and by analysing various systems of divination, notably the I Ching. Philosophical theory of causality has given no significant attention to synchronicity; the events of synchronicity are regarded as chance. The Neapolitan philosopher Giambattista Vico (1668-1744) developed a doctrine of historical experience and of self-knowledge that grounds the phenomenon of synchronicity in a metaphysics. James Joyce employed Vico's conception of language and historical cycles as the basis of Joyce's final literary work, Finnegans Wake. Vico's metaphysical sense of synchronicity and Joyce's literary formulation offer a grounding of this principle in non-divinatory sources in modern Western thought, something which Jung's discussion does not provide. These philosophical and literary perspectives complement Jung's to offer an expanded context in which to recognize synchronicity and to make sense of it.

  19. From Copenhagen to the consulting room: Pauli and Jung in Copenhagen.

    Science.gov (United States)

    Gieser, Suzanne

    2014-04-01

    In this paper the city of Copenhagen is used as a starting point to highlight some critical historical events, both concerning the exchange of ideas between the physicist Wolfgang Pauli and C.G. Jung and the history of psychotherapy in Scandinavia. Pauli's years in Copenhagen under the influence of Niels Bohr and his philosophy prepared him mentally to receiveC.G. Jung's ideas. The paper also recounts the one occasion that Jung was in Scandinavia, attending the 9th conference of the General Medical Society for Psychotherapy in Copenhagen, just before going to New York in 1937 to give his final seminars on Pauli's dreams. The reason for focusing on these particular events is that they also constitute part of the history of the reception of psychodynamic psychology in Sweden and Scandinavia. © 2014, The Society of Analytical Psychology.

  20. The Unifying Function of Affect: Founding a Theory of Psychocultural Development in the Epistemology of John Dewey and Carl Jung

    Science.gov (United States)

    Dunlap, Peter T.

    2012-01-01

    In this paper I explore the shared interest of John Dewey and Carl Jung in the developmental continuity between biological, psychological, and cultural phenomena. Like other first generation psychological theorists, Dewey and Jung thought that psychology could be used to deepen our understanding of this continuity and thus gain a degree of control…

  1. The Unifying Function of Affect: Founding a Theory of Psychocultural Development in the Epistemology of John Dewey and Carl Jung

    Science.gov (United States)

    Dunlap, Peter T.

    2012-01-01

    In this paper I explore the shared interest of John Dewey and Carl Jung in the developmental continuity between biological, psychological, and cultural phenomena. Like other first generation psychological theorists, Dewey and Jung thought that psychology could be used to deepen our understanding of this continuity and thus gain a degree of control…

  2. La Psique Latinoamericana: Breve Ensayo Hermenéutico Desde Freud y Jung Latin-American Psyche: Brief Hermeneutic Essay Based on Freud and Jung

    Directory of Open Access Journals (Sweden)

    Jorge Gissi

    2004-05-01

    Full Text Available El artículo integra algunas tesis de Freud y de Jung y las aplica a la psique latinoamericana. Según el autor, la conquista española en América, fue y aún es psicoculturalmente, distinta para conquistadores y conquistados. Desde la perspectiva de Freud, el análisis se basa en la segunda tópica, en la teoría de los mecanismos de defensa y en el complejo de Edipo. Se relacionan conflictos represivos, castratorios, proyectivos, etc. en los grupos culturales en pugna, y las derivaciones familiares y psicopolíticas congruentes. Desde Jung, el análisis se realiza a través de mitos y símbolos, lo que refleja una no integración sana de los arquetipos y un fuerte componente patriarcal de dominación. Esto implica la baja individuación, el "yo débil" y las disociaciones descubiertas por Freud.This article joins together some of Freud's and Jung's thesis and applies them into the Latin-American psyche. The author states that Spaniard's conquer period in America was, and still is, very different for conquerors and conquered (from a psychological and cultural point of view. From a Freudian approach, the analysis is based on the "Topica II", on the defense mechanisms theory and the Oedipus complex. In both groups, the author relates repressive conflicts, castration, projection, etc., with its familiar and psycho-political consequences. From Jung, the analysis is made with myths and symbols, which reflects a strong patriarchal component of domination and a unwholesome integration of the archetypes. This implies the low individuation, the "weak self" and the dissociations discovered by Freud.

  3. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    Science.gov (United States)

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…

  4. The cryptomnesic origins of Jung's dream of the multi-storeyed house.

    Science.gov (United States)

    Myers, Steve

    2009-09-01

    Jung first recounted his dream of the multi-storeyed house in the 1925 seminars to illustrate the concept of the collective unconscious and explain the influence of phylogeny on his split with Freud. However, his telling the story of the dream belies a cryptomnesic influence of the early writings of psychoanalysis because Josef Breuer used a similar image to illustrate the structure of the psyche which Edouard Claparède associated with a phylogenetic inheritance. When telling the story of the dream, Jung misrepresented Freud's position, creating the impression of there being a bigger difference between their theories than was actually the case, and giving the dream a fictional significance for the breakdown of their relationship. In fact, Jung followed Freud into the fields of mythology and phylogenetics, and their split was due primarily to their different attitudes towards sexuality rather than phylogeny. The dream image has therefore led to a misunderstanding of Freudian theory when viewed from within a Jungian perspective. Freud believed there was a phylogenetic layer in the psyche, though he held a different view to Jung on its nature and importance.

  5. Jung's Red Book and its relation to aspects of German idealism.

    Science.gov (United States)

    Bishop, Paul

    2012-06-01

    The late nineteenth century saw a renaissance of interest in the thought of the German Romantic philosopher, F.W.J. Schelling. This paper takes Jung's engagement with Schelling and his awareness of Schellingian ideas and interests (notably, the mysterious Kabeiroi worshipped at Samothrace) as its starting-point. It goes on to argue that a key set of problematics in German Idealism - the relation between freedom and necessity, between science and art, and ultimately between realism and idealism - offers a useful conceptual framework within which to approach Jung's Red Book. For the problem of the ideal is central to this work, which can be read as a journey from eternal ideals to the ideal of eternity. (Although the term 'idealism' has at least four distinct meanings, their distinct senses can be related in different ways to Jung's thinking.) The eloquent embrace of idealism by F.T. Vischer in a novel, Auch Einer, for which Jung had the highest praise, reminds us of the persistence of this tradition, which is still contested and debated in the present day. © 2012, The Society of Analytical Psychology.

  6. Ghost and self: Jung's paradigm shift and a response to Zinkin.

    Science.gov (United States)

    Rowland, Susan

    2009-11-01

    Zinkin's lucid challenge to Jung makes perfect sense. Indeed, it is the implications of this 'making sense' that this paper addresses. For Zinkin's characterization of the 'self' takes it as a 'concept' requiring coherence; a variety of abstract non-contextual knowledge that itself has a mythical heritage. Moreover, Zinkin's refinement of Jung seeks to make his work fit for the scientific paradigm of modernity. In turn, modernity's paradigm owes much to Newton's notion of knowledge via reductionism. Here knowledge or investigation is divided up into the smallest possible units with the aim of eventually putting it all together into 'one' picture of scientific truth. Unfortunately, 'reductionism' does not do justice to the resonant possibilities of Jung's writing. These look forward to a new scientific paradigm of the twenty-first century, of the interactive 'field', emergence and complexity theory. The paper works paradoxically by discovering Zinkin's 'intersubjective self' after all, in two undervalued narratives by Jung, his doctoral thesis and a short late ghost story. However, in the ambivalences and radical fictional experimentation of these fascinating texts can be discerned an-Other self, one both created and found.

  7. The Prayer-Poem and Jung's Use of Active-Imagination.

    Science.gov (United States)

    Molton, Warren L.

    1996-01-01

    Develops the concept of the prayer-poem as a method for spiritual search. Relates the process of the prayer-poem to Carl Jung's use of "active imagination" as a way of pushing the poetic image to a deeper level of meaning and usefulness: a window into the psyche (soul). (SR)

  8. The Jung Curriculum. An Interdisciplinary Curriculum and Resource Packet Designed for Secondary Students.

    Science.gov (United States)

    Doyle, Patricia E.; Fuller, Roger J.

    The ideas and concepts of Carl Jung are the basis for the materials of this curriculum guide for teaching gifted students at the secondary level. Entitled "Man and His Symbols," the guide is organized in five parts: (1) Approaching the Unconscious; (2) Ancient Myths and Modern Man; (3) The Process of Individuation; (4) Symbolism in the Visual…

  9. Parallels in the Beliefs and Works of Margaret Fuller and Carl Jung

    Directory of Open Access Journals (Sweden)

    Jerry Aldridge

    2011-05-01

    Full Text Available Margaret Fuller, the 19th-century feminist and Transcendentalist, has been compared with Louisa May Alcott, Ralph Waldo Emerson, Nathaniel Hawthorne, and Henry David Thoreau. The life and theories of Carl Jung, the 20th-century psychiatrist, have been compared with the works of Sigmund Freud, Alfred Adler, Jean Piaget, and Sabina Spielrein among others. However, no comparisons have been published concerning the beliefs and works of Fuller and Jung. The purpose of this research was to compare and contrast the beliefs and written works of Margaret Fuller and Carl Jung. Similarities and differences were reported among their ideologies. Similarities in their childhood and adult dreams, literary references, spiritual beliefs, and explorations of gender were described. Differences were reported, which included the focus of their writings and their ideas about who is to blame when things go wrong, and how to deal with the individual daemon in each person was also explored. Special consideration was given to how closely their writings intersect. Specifically, the authors questioned whether Jung was inspired by the ideas and writings of Fuller. To answer this question, five possibilities were identified.

  10. Another Woman Gets Robbed? What Jung, Freud, Piaget, and Vygotsky Took from Sabina Spielrein

    Science.gov (United States)

    Aldridge, Jerry

    2009-01-01

    Certainly not as many who have heard the names of Carl Jung, Sigmund Freud, Jean Piaget, and Lev Vygotsky, have heard of Sabina Spielrein. While Spielrein had numerous face-to-face encounters, some personal and some professional, with all four men, and the accounting of her life and the interactions she had with them has been the content of…

  11. Unresolved Questions in the Freud/Jung Debate. On Psychosis, Sexual Identity and Religion

    NARCIS (Netherlands)

    Vandermeersch, Patrick

    1991-01-01

    Due to the fact that the phenomenon of religion has been set aside as being something 'different', a number of key problems within psycho¬an¬alysis have been unwittingly lost from sight. This is especially true for the central theme of the Freud Jung debate: the experience of reali¬ty. The experienc

  12. Synchronicity - The Link Between Physics and Psyche, from Pauli and Jung to Chopra

    Science.gov (United States)

    Teodorani, M.

    2006-07-01

    This book, which is entirely dedicated to the mystery of "synchronicity", is divided into three parts: a) the joint research between analytic psychologist Carl Gustav Jung and quantum physicist Wolfgang Pauli; b) synchronicity mechanisms occurring in the microscopic (canonical quantum entanglement), mesoscopic and macroscopic scales; c) research and philosophy concerning synchronicity by MD Deepak Chopra.

  13. Interlocução entre Rudolf Otto, Carl Gustav Jung e Victor White

    Directory of Open Access Journals (Sweden)

    Rodrigo Pereira Ceccon

    2012-01-01

    Full Text Available En 1917, Rudolf Otto publicó el libro Lo Sagrado que propone el reconocimiento del aspecto irracional como el fundamento y sostén de la expresión religiosa a través de analogías y antinomias que llamó lo numinoso. Más tarde, en una conferencia en1937, Carl Gustav Jung utiliza el término numinoso para aclararlo dilucidar qué entiende por religión, reconociéndola como una observación sobre lo que arrebata la conciencia, ampliando de esta manera la idea de numinoso a la práctica y el estudio clínico. Víctor White, principal colaborador de Jung en el campo de la teología, teje una crítica sobre las posiciones de Otto y Jung de comprender el fenómeno religioso, afirmando que tienen una actitud unilateral en el reconocimiento de que sólo la esfera irracional fundamenta la religión. Este artículo propone una discusión teórica alrededor de las reflexiones de White en la idea de lo numinoso, contra las posiciones de Otto y Jung.

  14. Another Woman Gets Robbed? What Jung, Freud, Piaget, and Vygotsky Took from Sabina Spielrein

    Science.gov (United States)

    Aldridge, Jerry

    2009-01-01

    Certainly not as many who have heard the names of Carl Jung, Sigmund Freud, Jean Piaget, and Lev Vygotsky, have heard of Sabina Spielrein. While Spielrein had numerous face-to-face encounters, some personal and some professional, with all four men, and the accounting of her life and the interactions she had with them has been the content of…

  15. Jung's psychoid concept and Bion's proto-mental concept: a comparison.

    Science.gov (United States)

    Addison, Ann

    2016-11-01

    Jung and Bion both developed theoretical concepts propounding a deeply unknowable area of the psyche in which body and mind are undifferentiated and the individual has no distinct identity, from which a differentiated consciousness arises. In Jung's case, this is enshrined in his psychoid concept and the associated notion of synchronicity and, in Bion's case, in his proto-mental concept and his ideas on group dynamics. It is by means of these two concepts that Jung and Bion approach and locate a combined body-mind, a monism, in which body and mind are seen as different aspects of the same thing. This paper reviews the claim that although the two concepts are associated clinically with very different situations, their commonality may arise from a similar intellectual basis: both men appear to have been influenced by the same source of vitalist ideas in philosophy including Henri Bergson, and Jung's ideas also exerted a direct influence on Bion. © 2016, The Society of Analytical Psychology.

  16. Psyche=singularity: A comparison of Carl Jung's transpersonal psychology and Leonard Susskind's holographic string theory

    Science.gov (United States)

    Desmond, Timothy

    In this dissertation I discern what Carl Jung calls the mandala image of the ultimate archetype of unity underlying and structuring cosmos and psyche by pointing out parallels between his transpersonal psychology and Stanford physicist Leonard Susskind's string theory. Despite his atheistic, materialistically reductionist interpretation of it, I demonstrate how Susskind's string theory of holographic information conservation at the event horizons of black holes, and the cosmic horizon of the universe, corroborates the following four topics about which Jung wrote: (1) his near-death experience of the cosmic horizon after a heart attack in 1944; ( 2) his equation relating psychic energy to mass, "Psyche=highest intensity in the smallest space" (1997, 162), which I translate into the equation, Psyche=Singularity; (3) his theory that the mandala, a circle or sphere with a central point, is the symbolic image of the ultimate archetype of unity through the union of opposites, which structures both cosmos and psyche, and which rises spontaneously from the collective unconscious to compensate a conscious mind torn by irreconcilable demands (1989, 334-335, 396-397); and (4) his theory of synchronicity. I argue that Susskind's inside-out black hole model of our Big Bang universe forms a geometrically perfect mandala: a central Singularity encompassed by a two-dimensional sphere which serves as a universal memory bank. Moreover, in precise fulfillment of Jung's theory, Susskind used that mandala to reconcile the notoriously incommensurable paradigms of general relativity and quantum mechanics, providing in the process a mathematically plausible explanation for Jung's near-death experience of his past, present, and future life simultaneously at the cosmic horizon. Finally, Susskind's theory also provides a plausible cosmological model to explain Jung's theory of synchronicity--meaningful coincidences may be tied together by strings at the cosmic horizon, from which they

  17. Jung, the trickster writer, or what literary research can do for the clinician.

    Science.gov (United States)

    Rowland, Susan

    2006-04-01

    This paper aims to show how literary scholarship can contribute to clinical debates by offering different methods of reading and interpreting works by Jung. Firstly, as texts form much of the means by which Jungian ideas are transmitted and worked upon, literary research offers methods of examining the way we read for authority and orthodoxy. Secondly, it is invaluable to look at the way in which Jung actually wrote. Jung portrays a dynamic psyche in action in his writings. His works are not only about a creative archetypal psyche, they enact and perform this creativity in the way in which he uses words. The rich playfulness demonstrated in The Collected Works is an example of a writer as a mythmaker of the psyche, one who absorbs unconscious creative energies into his writing in ways that dissolve modernity's cultural boundaries of science and art. In addition, the aesthetic component in Jung's writing is not a decoration of his ideas. Rather, his 'literary' qualities are themselves forms of argument about the fragile state of modern subjectivity. Using his essays on 'Synchronicity', and the 'Trickster', the paper will show these works to be responses to three related crises that still face clinicians and scholars today: the problematic role of the hero myth as an individuation narrative, the nature of 'science', and the crisis of western modernity itself in desperate need of psychic healing. The paper will show that where writing on synchronicity aims to individuate science by adding a 'feminine' Eros to its Logos biases, the Trickster essay is designed to ameliorate modernity by providing frameworks to make visible marginal or excluded material. In these works Jung tries to rejuvenate the modern world by re-connecting traditional symbolic systems with the psyche through myth as a language of psychic relating.

  18. Carl Jung's interpretation of Wolfgang Pauli's dreams: The Bailey Island, Maine, and New York City seminars of 1936 and 1937

    Science.gov (United States)

    Brown, Richard Paul

    This dissertation reviewed the development of Jung's dream theory and addresses the question as to whether or not Jung was influenced by the dreams of the Nobel Prize winning physicist, Wolfgang Pauli. Jung provided an extensive analysis of Pauli's dreams, which are contained in the lightly edited, unpublished transcripts of lectures delivered in 1936 and 1937. An archival and hermeneutic analysis of the texts reveals a staged process of individuation that Jung related to in many ways because of the parallels to his own personal journey toward individuation. A chronological history of the development of Jung's dream theory is presented, followed by a picture of the relationship between Jung and Pauli. Thereafter, a detailed summary of the seminar transcripts, one given on Bailey Island, Maine, and the other in New York City the following year, is offered with hermeneutic commentary. An analysis of the seminars found that Pauli's dreams did, in part, support Jung's theory. Specifically, while Jung was unable to meet the scientific demands for clear empirical evidence of his dream theory, he did offer his professional and non-professional audiences with a slightly less rigorous example of his dream theory in action, demonstrating that the process shared similarities across peoples, time, and cultures. Additionally, in Pauli he found a superior mind that had gone through the process of individuation in accordance with his theory and his own experience. During the course of research, reference to a document was found in the correspondence in the Jungian Archives in Zurich. This document entitled, "FAREWELL SPEECH, Given by Dr. C. G. Jung on the Occasion of a Dinner Given in His Honor by the Analytical Psychology Club of New York City October 26, 1937" and other related documents were subsequently uncovered in the sub-basement of the Kristine Mann Library in New York City. A synopsis of the discovery and description of the papers contained in the file are discussed in

  19. Learning from the patient: the East, synchronicity and transference in the history of an unknown case of C.G. Jung.

    Science.gov (United States)

    de Moura, Vicente

    2014-06-01

    This article presents the history of one until now unknown case of C.G. Jung: Maggy Reichstein. Born in Indonesia in 1894 in a very aristocratic family, she brought her sister to Zurich to be treated by Jung in 1919, and later she herself was in analysis with him. Jung used her case as example in his lecture in 1937 on the realities of practical psychotherapy, relating it to the process of transference and countertransference. Jung deepened his studies in Eastern psychology after a series of dreams she had, which culminated in the Yoga Kundalini Seminars. She was also the case presented in his article of 1951 on the concept of synchronicity. Jung wrote that her case, concerning synchronicity, remained unique in his experience. Jung also published some of her mandalas. He considered her able to understand his ideas in depth. Reichstein was for Jung an important case, which challenged and triggered his interests in different subjects.

  20. Phytoavailability of cadmium (Cd) to Pak choi (Brassica chinensis L.) grown in Chinese soils: a model to evaluate the impact of soil Cd pollution on potential dietary toxicity.

    Science.gov (United States)

    Rafiq, Muhammad Tariq; Aziz, Rukhsanda; Yang, Xiaoe; Xiao, Wendan; Stoffella, Peter J; Saghir, Aamir; Azam, Muhammad; Li, Tingqiang

    2014-01-01

    Food chain contamination by soil cadmium (Cd) through vegetable consumption poses a threat to human health. Therefore, an understanding is needed on the relationship between the phytoavailability of Cd in soils and its uptake in edible tissues of vegetables. The purpose of this study was to establish soil Cd thresholds of representative Chinese soils based on dietary toxicity to humans and develop a model to evaluate the phytoavailability of Cd to Pak choi (Brassica chinensis L.) based on soil properties. Mehlich-3 extractable Cd thresholds were more suitable for Stagnic Anthrosols, Calcareous, Ustic Cambosols, Typic Haplustalfs, Udic Ferrisols and Periudic Argosols with values of 0.30, 0.25, 0.18, 0.16, 0.15 and 0.03 mg kg-1, respectively, while total Cd is adequate threshold for Mollisols with a value of 0.86 mg kg-1. A stepwise regression model indicated that Cd phytoavailability to Pak choi was significantly influenced by soil pH, organic matter, total Zinc and Cd concentrations in soil. Therefore, since Cd accumulation in Pak choi varied with soil characteristics, they should be considered while assessing the environmental quality of soils to ensure the hygienically safe food production.

  1. DHS HS-STEM Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Anna Christine [Sandia National Laboratories (SNL-CA), Livermore, CA (United States)

    2014-09-01

    Throughout my HS-STEM internship, I worked on two different projects with a systems analysis group at Sandia National Laboratories in Livermore, California (SNLCA). The first, and primary, project entailed building a conceptual model of health surveillance detection of a bioterror attack. The second project was much smaller in scope and looked at cost tradeoffs between volumetric and surface decontamination after the release of anthrax in a city. Both projects helped me to understand the challenges of planning for a bioterror attack and the importance of preparedness in the public health sector.

  2. the doubly magic nucleus 270Hs

    Directory of Open Access Journals (Sweden)

    Silisteanu I.

    2016-01-01

    Full Text Available The α-decay and spontaneous fission half-lives of nuclei around 270Hs are calculated with formulas derived from an in-depth analysis of the available experimental data and of results of theoretical models. The parameters of these formulas result from the fit of half-lives with respect to the reaction energies, the height of the SF barrier and the fissionability. The calculated partial and total half-lives are compared with the experimental data and results of other approximations. Half-life predictions are made for many unknown nuclei.

  3. A psicologia analítica de Carl Gustav Jung: apontamentos de aula/The analytical psychology of Carl Gustav Jung: notes of lesson

    OpenAIRE

    Luís Marcelo Alves Ramos

    2005-01-01

    O texto traz o conteúdo de uma aula sobre Teorias da Personalidade com foco nos fundamentos da Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung (1875-1961), cuja obra vem apresentando significativas contribuições para a Psicologia Educacional, Organizacional e Clínica. Palavras-chave Psicologia analítica; Teorias da personalidade Abstract The text brings the content of a lesson on Theories of Personality focused in the fundamentals of the Analytical Psychology of...

  4. Synchronicity and the I Ching: Jung, Pauli, and the Chinese woman.

    Science.gov (United States)

    Zabriskie, Beverley

    2005-04-01

    The capacity of the human mind to discover and invent both imagistic analogies and mathematical structures to represent reality is strikingly juxtaposed in the ancient Chinese text of the I Ching. Its emphasis on containing all sorts of opposites and its plastic appeal to multi-valenced experience has kept it alive through millennia and across cultures. Jung was introduced to its Taoist wisdom by the Sinologist Richard Wilhelm. The Nobel Laureate quantum physicist Wolfgang Pauli became familiar with its philosophy and mathematics through his reading of Schopenhauer and Leibniz. In their correspondence about the nature of the unconscious and synchronicity, Pauli and Jung also exchanged their musings on Pauli's dreams of a Chinese woman, her role in his psyche and his scientific theories(1).

  5. Saying goodbye to the hero: Jung, Liber Novus and conversion from addiction.

    Science.gov (United States)

    Addenbrooke, Mary

    2015-06-01

    Two chapters in Liber Novus throw fresh light on Jung's epistemology of addiction. Taking these as a starting point, the nature of the challenges that patients confront in leaving addiction behind are explored. It is suggested that an archetypal process of separation is constellated at the point of quitting as the precursor to a life without the object of the addiction. A short account is given of Jung's part in the inception of Alcoholics Anonymous and the potential role of a 'conversion experience' as an initiation into psychological reorientation away from the negative individuation experienced by the hero. The case of a patient addicted to heroin illustrates the contribution of an analytic approach in an NHS setting, along with other workers in a rehabilitation centre. Certain challenges of working with addicted people are outlined, including arousal of the psychotherapist's rescue fantasies.

  6. The correspondence between Erich Neumann and C.G. Jung on the occasion of the November, progroms 1938 [corrected].

    Science.gov (United States)

    Löwe, Angelica

    2015-06-01

    In the light of recently-published correspondence between Jung and Neumann, this paper considers and connects two aspects of their relationship: Jung's theory of an ethno-specific differentiation of the unconscious as formulated in 1934, and the relationship between Jung and Neumann at the beginning of the Holocaust in 1938-with Jung as the wise old man and a father figure on one hand, and Neumann as the apprentice and dependent son on the other. In examining these two issues, a detailed interpretation of four letters, two by Neumann and two by Jung, written in 1938 and 1939, is given. Neumann's reflections on the collective Jewish determination in the face of the November pogroms in 1938 led Jung to modify his view, with relativization and secularization of his former position. This shift precipitated a deep crisis with feelings of disorientation and desertion in Neumann; the paper discusses how a negative father complex was then constellated and imaged in a dream. After years of silence, the two men were able to renew the deep bonds that characterized their lifelong friendship.

  7. Old Age and Spirituality - Metanoia, "The second half of life" according to Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Irene Pereira Gaeta Arcuri

    2013-03-01

    Full Text Available This study shows the possibility of old age as human development, since the second half of life is the period of spiritual growth. Jung is a classic illustration of metanoia showing what connects and what distinguishes the second half of life. It is as if the focus change and a shift occurred. The focus may be because the ego does not find this place the foundation that once experienced as a solid foundation, and is directed to the Self.

  8. Relationship Between Personality Types Conceptualized by C. G. Jung and Emotional Intelligence

    OpenAIRE

    Natasha Virmozelova; Mariana Dimitrova

    2013-01-01

    The main aim of this study is to present the results from a study of the relationship between personality types described by C. G. Jung and emotional intelligence. The investigated subjects were 150 at the age of 18 – 50. The methods of research were MBTI (Myers-Briggs Type Indicator) - Bulgarian adaptation (Rusinova, 1992) and one psychological questionnaire measuring emotional intelligence -Bulgarian adaptation (Stoyanova, 2008). The received data indicated that the functions of thinking an...

  9. Freud, Jung e o Homem dos Lobos: percalços da psicanálise aplicada Freud, Jung and the Wolfman: benefits of applied psychoanalysis

    Directory of Open Access Journals (Sweden)

    Paulo Endo

    2001-06-01

    Full Text Available Pretende-se examinar o papel da analogia no pensamento freudiano, através de um período fértil e tumultuado do movimento psicanalítico, marcado pela intensificação das divergências entre Freud e seu dileto (Jung, e também pelo crescimento do movimento da psicanálise aplicada entre Freud e seus discípulos e pelo trabalho analítico daquele que é, talvez, o mais importante caso clínico escrito por Freud: o caso do Homem dos Lobos. Este período marca um imenso campo de debates clínicos e teóricos, entre os quais se inclui, sem dúvida, o problema da analogia na teoria e na clínica psicanalíticas.This article intends to examine the role of analogy in the Freudian thought. With this in mind we will visit a very hectic and productive period in the psychoanalytical movement. This period was marked by the divergences between Freud and Jung, by the expansion of the applied psychoanalytical movement between Freud and his disciples, and by the analytical work of the Wolfman (which might be considered Freud's most important case. This period marks a huge field of clinical and theoretical debates, among which the problem of analogy in theory and in clinical psychoanalysis is undoubtedly included.

  10. Faint voices from Greenwich Village: Jung's impact on the first American avant-garde.

    Science.gov (United States)

    Sherry, Jay

    2011-11-01

    In 1913 Jung made a trip to New York which was to have an important impact on the creation of modern American culture. At the invitation of Beatrice Hinkle, the first Jungian analyst in the country, he spoke to the Liberal Club, a forum for discussing progressive topics. Jung was the leading spokesman for psychoanalysis and his ideas about creative fantasy resonated with popular interest in the ideas of William James and Henri Bergson. This paper will document that visit and the influence that Hinkle had on the young people who had gravitated to Greenwich Village. She promoted Jungian psychology through her analytical practice and her translation of Jung's Wandlungen und Symbole der Libido as Psychology of the Unconscious. Her influence is evident in four key neighbourhood institutions: The Masses, a socialist magazine, The Seven Arts, an avant-garde literary magazine, the Provincetown Players theatre ensemble, and the Heterodoxy Club, America's first feminist group. Her influence is also evident at The New School where several pioneering anthropologists employed the theory of psychological types as a tool for understanding social behaviour. This paper will demonstrate that a cultural moment usually seen through a Freudian lens had, in fact, a remarkably Jungian character.

  11. The Fibonacci Life-Chart Method (FLCM) as a foundation for Carl Jung's theory of synchronicity.

    Science.gov (United States)

    Sacco, Robert G

    2016-04-01

    Since the scientific method requires events to be subject to controlled examination it would seem that synchronicities are not scientifically investigable. Jung speculated that because these incredible events are like the random sparks of a firefly they cannot be pinned down. However, doubting Jung's doubts, the author provides a possible method of elucidating these seemingly random and elusive events. The author draws on a new method, designated the Fibonacci Life-Chart Method (FLCM), which categorizes phase transitions and Phi fractal scaling in human development based on the occurrence of Fibonacci numbers in biological cell division and self-organizing systems. The FLCM offers an orientation towards psychological experience that may have relevance to Jung's theory of synchronicity in which connections are deemed to be intrinsically meaningful rather than demonstrable consequences of cause and effect. In such a model synchronistic events can be seen to be, as the self-organizing system enlarges, manifestations of self-organized critical moments and Phi fractal scaling. Recommendations for future studies include testing the results of the FLCM using case reports of synchronistic and spiritual experiences. © 2016, The Society of Analytical Psychology.

  12. Jung on the Nature and Interpretation of Dreams: A Developmental Delineation with Cognitive Neuroscientific Responses

    Science.gov (United States)

    Zhu, Caifang

    2013-01-01

    Post-Jungians tend to identify Jung’s dream theory with the concept of compensation; they tend to believe that Jung’s radically open stand constitutes his dream theory in its entirety. However, Jung’s theory regarding dreams was a product of an evolving process throughout his whole intellectual and professional life. Unfortunately, the theory has not been understood in such a developmental light. Based on a historical and textual study of all dream articles found throughout The Collected Works of C.G. Jung, this paper maps a concise three-phase trajectory of Jung’s changing views on dreams and interpretation. The paper posits that Jung’s last essay, “Symbols and the Interpretation of Dreams” (1961), epitomizes his final stand, although such a stand is also reflected in a less explicit and less emphatic way during the latter period of the second phase. The paper also briefly addresses where Jung and Jungians have been enigmatic or negligent. For example, it has not been explicated fully why compensation as slight modifications and compensation as parallels to waking life situations are rare in Jung’s cases In addition, contemporary cognitive and neuroscientific approaches to the study of dreams, as represented by Harry Hunt, William Domhoff, and Allan Hobson, among others, are presented in connection with Jung. The juxtaposition of Jungian, cognitive, and neuroscientific approaches showcases how cognitive and scientific findings challenge, enrich, and in some ways confirm Jung’s dream theory and praxis. PMID:25379263

  13. Jung on the Nature and Interpretation of Dreams: A Developmental Delineation with Cognitive Neuroscientific Responses

    Directory of Open Access Journals (Sweden)

    Caifang Zhu

    2013-11-01

    Full Text Available Post-Jungians tend to identify Jung’s dream theory with the concept of compensation; they tend to believe that Jung’s radically open stand constitutes his dream theory in its entirety. However, Jung’s theory regarding dreams was a product of an evolving process throughout his whole intellectual and professional life. Unfortunately, the theory has not been understood in such a developmental light. Based on a historical and textual study of all dream articles found throughout The Collected Works of C.G. Jung, this paper maps a concise three-phase trajectory of Jung’s changing views on dreams and interpretation. The paper posits that Jung’s last essay, “Symbols and the Interpretation of Dreams” (1961, epitomizes his final stand, although such a stand is also reflected in a less explicit and less emphatic way during the latter period of the second phase. The paper also briefly addresses where Jung and Jungians have been enigmatic or negligent. For example, it has not been explicated fully why compensation as slight modifications and compensation as parallels to waking life situations are rare in Jung’s cases In addition, contemporary cognitive and neuroscientific approaches to the study of dreams, as represented by Harry Hunt, William Domhoff, and Allan Hobson, among others, are presented in connection with Jung. The juxtaposition of Jungian, cognitive, and neuroscientific approaches showcases how cognitive and scientific findings challenge, enrich, and in some ways confirm Jung’s dream theory and praxis.

  14. Produção de repolho branco chinês (pak choi sob proteção com "não tecido" de polipropileno Yield of pak choi crop under non woven polypropylene

    Directory of Open Access Journals (Sweden)

    Marie Y. Reghin

    2002-06-01

    Full Text Available O cultivo do repolho branco chinês (pak choi (Brassica campestris var. chinensis foi avaliado nas condições de inverno dos Campos Gerais (PR, sob proteção, com "não tecido" de polipropileno branco, também conhecido como agrotêxtil, nas gramaturas de 17 e 25 g/m², comparado com o cultivo sem proteção. Os híbridos usados foram Canton e Chouyou com semeadura em bandejas de poliestireno expandido em 11/05/00 e transplante no estádio de 4-5 folhas definitivas, em 23/06/00. O delineamento experimental foi de blocos casualizados com 5 repetições, tendo os tratamentos seguido esquema fatorial 3x2. Cada parcela teve 36 plantas distribuídas no espaçamento 0,30 x 0,30m. Após o transplante, nas parcelas respectivas, as plantas foram cobertas com o agrotêxtil como uma manta flutuante. As avaliações na colheita, realizada de acordo com a maturidade das plantas foram: número de folhas, altura da parte aérea, diâmetro da base, peso de matéria fresca e matéria seca de plantas. A porcentagem de plantas com florescimento prematuro foi avaliada aos 51 dias. No cultivo sem proteção, as plantas do híbrido Canton foram prejudicadas pela geada, apresentando os bordos foliares totalmente queimados, enquanto o híbrido Chouyou não teve nenhum sintoma visual de dano por geada. O agrotêxtil protegeu as plantas contra a geada e contribuiu para o desenvolvimento mais rápido das plantas, possibilitando colheita precoce aos 38 dias do transplante quando usou-se gramatura de 25 g/m² e aos 42 dias na de 17 g/m². No cultivo sem proteção, a colheita ocorreu somente aos 46 dias. Entre os híbridos, Canton foi mais precoce que Chouyou. No entanto, Canton foi suscetível ao florescimento prematuro na estação de inverno, apresentando algumas plantas com esta ocorrência aos 36 dias do transplante. A proteção com polipropileno promoveu a produção de plantas com qualidade superior do produto observada através das características de maior peso

  15. The variable "Jung" as a predictor of mortality in patients with pulmonary edema

    Directory of Open Access Journals (Sweden)

    Jung Robert

    2013-01-01

    Full Text Available Background/Aim. In our Intensive Coronary Care Unit (CCU a specific scoring system named the AMIS_NS was developed both for prediction of mortality in patients with acute myocardial infarction and for evaluation of the quality of work. One of the most important variables of the AMIS_NS system is the variable Jung which stands for the interrelationship unified mortality predictors. The variable includes all the values of systolic blood pressure, heart rate and age, without limiting values for any of these. The cutoff value is 2.08. The patients with the lower variable value account for a significantly higher mortality. Data on the actual infarction are not necessitated now for this variable. The aim of this study was to assess the significance of the variable Jung in non-infarction patients with acute pulmonary edema. Methods. In a 24-month period out of 2,223 patients there were 1,087 and 1,136 patients with and without acute myocardial infarction, respectively. There was the subgroup without myocardial infarction of 312 (84.1% patients admitted with the diagnosis of pulmonary edema. The subgroup with myocardial infarction consisted of 59 (15.9% patients who were admitted for acute myocardial infarction and pulmonary edema which developed immediately after admission or during hospitalization in the CCU. For all the patients a uniform questionnaire was fulfilled on admission. Data were put into the personal computer. The variable “Jung” was used: (systolic bloog pressure/heart rate × age × 100. Results. Regarding sex, there was no difference in mortality, so that males and females were regarded as a whole. Previous myocardial infarction was equally registered in both groups. The investigated persons had less percent of mortality and a significantly higher systemic pressure as well as higher value of the variable Jung. There was no statistically significant difference in the heart rate between the two groups. In both groups of deceased

  16. Occupational Accident Declaration Form (HS50)

    CERN Multimedia

    HR Department

    2007-01-01

    https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under the occupational scheme in the event of cure (defined in § 15 as the certified end to the impairment of the patient’s state of health caused by the illness or accident), or consolidation (defined in § 14 as certification that no further improvement in the patient’s state of health can be expected from appropriate medical treatment). The right to such reimbursement shall resume only in the...

  17. The Martin Buber-Carl Jung disputations: protecting the sacred in the battle for the boundaries of analytical psychology.

    Science.gov (United States)

    Stephens, B D

    2001-07-01

    The Martin Buber-C.G. Jung disputations rather than the Freud-Jung split or Samuels's post-Jungian categories is considered the more significant paradigm for understanding the conflicts erupting within the Jungian community surrounding clinical practice and candidate training. Looking through the lens of the Freud-Jung split keeps the conflicts focused on the theoretical and technical differences concerning such concepts as object-relations, transference-countertransference, neutrality, clinical boundaries. The Buber-Jung disputations move the discussion into a different and more foundational arena, namely the vertical and horizontal psychological considerations of the experience of the Sacred and how that dimension is supported or thwarted in clinical practice and candidate training by the respective allegiances of the 'warriors' in the 'Holy Wars'. Experiencing the texture of the Buber-Jung disputations as well as grappling with their content suggests that a more dialogical approach to actual clinical material may be a more fruitful way to understand the work of analysis and the business of candidate training.

  18. Analysis of the HI-6, HS-3 and HS-6, Influence on the Liver Methabolizing Enzyme Systems

    Science.gov (United States)

    2001-09-01

    ON THE LIVER METHABOLIZING ENZIME SYSTEMS Christophor Dishovsky, Maria Kadiiska*, Petko Alov* Military Medical Academy, 1606, Sofia, Bulgaria...reactivators of ChE, liver, methabolizing enzime systems FIGURES AND TABLES Table 1. Effect of reactivators of ChE HS-3, HS-6, HI-6 on the hexobarbital

  19. Has the Time Come to Emulate Jung? A Response to Piechowski's Most Recent Rethinking of the Theory of Positive Disintegration: I. The Case against Primary Integration

    Science.gov (United States)

    Mendaglio, Sal; Tillier, William

    2015-01-01

    Disagreements between theorists and their collaborators are as old as the field of psychology itself. The most well-known example of a professional relationship marked by diverging viewpoints in psychology is that of Sigmund Freud and Carl Jung. Theoretical disagreements between them were resolved by Jung's creation of a new theory. In this…

  20. Has the Time Come to Emulate Jung? A Response to Piechowski's Most Recent Rethinking of the Theory of Positive Disintegration: I. The Case against Primary Integration

    Science.gov (United States)

    Mendaglio, Sal; Tillier, William

    2015-01-01

    Disagreements between theorists and their collaborators are as old as the field of psychology itself. The most well-known example of a professional relationship marked by diverging viewpoints in psychology is that of Sigmund Freud and Carl Jung. Theoretical disagreements between them were resolved by Jung's creation of a new theory. In this…

  1. Under a Starry Vault. Warburg, Jung and the Renaissance of Ancient Paganisms at the Beginning of the 20th Century

    Directory of Open Access Journals (Sweden)

    Manuela Pallotto Strickland

    2015-11-01

    Full Text Available The paper tackles the controversial question of the affinities between the work of Aby Warburg and Carl Gustav Jung. Instead of focussing her interest exclusively on the concepts of collective memory and primordial images, though, the author critically compares the different ways Warburg and Jung looked at the renaissance of ancient practices of Paganism at the beginning of the Twentieth century, and questions the extent to which the cultural crisis heralded by Modernity, and the challenges brought about by secularisation influenced their reading of the revivals.

  2. A Comparison of Keywords in the Dynamic Psychology of Jung, Swedenborg and Freud

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    Leon James

    2015-08-01

    Full Text Available This article provides some comparative data on the frequency of occurrence of key words that can be found in the complete set of collected works of Gustav Jung (1875-1961, Emanuel Swedenborg (1688-1772, and Sigmund Freud (1856-1939. These three historically important writers have each made significant contributions to the formulation and development of dynamic and analytic psychology. These data provide a comparison of the intensity in topical focus in the works of these three writers. There is visible overlap between all three writers in the intensity of focus on certain key concepts. The overlap is greater between Jung and Swedenborg than between Freud and the other two. An interpretation of this finding is presented in terms of the attitude of each author regarding the existence of a psychic “world” that is distinct from the physical world. Freud’s individual unconscious is contrasted with Jung’s collective unconscious and Swedenborg’s collective conscious.

  3. Arendt, Jung e Humanismo: um olhar interdisciplinar sobre a violência Arendt, Jung and Humanism: an interdisciplinary approach to violence

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    Marlon Xavier

    2008-09-01

    Full Text Available O presente trabalho é um ensaio de natureza teórica que tece reflexões sobre o fenômeno da violência no mundo contemporâneo a partir da perspectiva dada pela filosofia política de Hannah Arendt. Partindo de sua interpretação de Kant, conectamos a teoria original sobre a violência de Arendt com sua base filosófica, o humanismo. À compreensão mais filosófica e social dada por Arendt, buscamos acrescentar, em uma abordagem interdisciplinar quiçá inédita para o tema, as contribuições dadas pela psicologia profunda de Jung, sendo discutida e sublinhada a relevância dos seus conceitos de indivíduo singular e inconsciente e da sua crítica da cultura. A origem comum de ambas as teorias leva a interpretações diferentes, mas complementares do fenômeno da violência, visto a partir das perspectivas social e individual, e conduz à afirmação da importância da retomada do humanismo como idéia central ao pensarmos a violência e o mundo contemporâneo.This article is a theoretical essay that reflects on the phenomenon of violence in the contemporary world, grounded on the perspective furnished by Hannah Arendt's political philosophy. Starting from her interpretation of Kant, we have connected Arendt's original theory on violence with its philosophical basis, Humanism. To the more philosophical and social understanding provided by Arendt, we have tried to add, through an interdisciplinary approach, the contributions given by Jung's depth psychology, discussing and underlining the relevance of his concepts of singular individual and unconscious and his critique of culture. The common origin of both theories leads to different yet complementary interpretations of the phenomenon of violence, and eventually to asserting the importance of recovering Humanism as a central idea in the way we understand violence and the contemporary world.

  4. Intralesional triamcinolone for flares of hidradenitis suppurativa (HS)

    DEFF Research Database (Denmark)

    Riis, Peter Theut; Boer, Jurr; Prens, Errol P

    2016-01-01

    BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence. OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone...

  5. Carl Jung.

    Science.gov (United States)

    Kyle, R A; Shampo, M A

    1978-11-17

    Physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. Chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of Plasmodium falciparum. For treatment of severe infections with P falciparum and for treatment of all infections due to chloroquine-resistant strains of P falciparum quinine is the suppressive agent of choice. Chloroquine is also the prophylactic agent of choice for most travelers. To prevent infection with P vivax or P ovale, primaquine must also be given. A RBC glucose-6-phosphate dehydrogenase level should be obtained before administration of primaquine. For prophylaxis of chloroquine-resistant strains of P falciparum, no completely satisfactory regime is presently available in the United States.

  6. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES) : A cross-sectional reference study

    NARCIS (Netherlands)

    Deckers, Inge E.; Janse, Ineke C.; van der Zee, Hessel H.; Nijsten, Tamar; Boer, Jurr; Horvath, Barbara; Prens, Errol P.

    2016-01-01

    Background: Hidradenitis suppurativa (HS) is a chronic debilitating disease, whereby school attendance and employment can be disturbed. Objective: We sought to determine the socioeconomic status (SES) in patients with HS relative to other dermatologic patients, and whether specific clinical HS

  7. The World Rests on a Turtle, but on What Does that Turtle Rest? A Reply to Haier and Jung

    Science.gov (United States)

    Sternberg, Robert J.

    2008-01-01

    In this article, I consider three general issues raised by Haier and Jung (2008). First, I discuss the use of drugs for intellectual enhancement. Second, I reflect on prediction of performance based on biological measures. Third, I query whether biology can tell us what intelligence and creativity are. I conclude that biological assessments raise…

  8. Un-thought out metaphysics in analytical psychology: a critique of Jung's epistemological basis for psychic reality.

    Science.gov (United States)

    Brooks, Robin McCoy

    2011-09-01

    The author investigates the relation of Kant, Schopenhauer and Heidegger to Jung's attempts to formulate theory regarding the epistemological conundrum of what can and what cannot be known and what must remain uncertain. Jung's ambivalent use and misuse of Kant's division of the world into phenomenal and noumenal realms is highlighted in discussion of concepts such as the psychoid archetype which he called 'esse in anima' and his use of Schopenhauer's concept of 'will' to justify a transcendence of the psyche/soma divide in a postulation of a 'psychoid' realm. Finally, the author describes Jung's reaction to Heidegger's theories via his assertion that Heidegger's 'pre-given world design' was an alternate formulation of his concept of the archetypes. An underlying theme of the paper is a critique of Jung's foundationalism which perpetuates the myth of an isolated mind. This model of understanding subjectivity is briefly contrasted with Heidegger's 'fundamental ontology' which focuses on a non-Cartesian 'understanding' of the 'presencing of being' in everyday social and historical contexts.

  9. Revisiting Jung's "A Psychological Approach to the Dogma of the Trinity": some implications for psychoanalysis and religion.

    Science.gov (United States)

    Lamborn, Amy Bentley

    2011-03-01

    This article explores one of C. G. Jung's generally neglected essays, his psychological interpretation of the Trinity, and links up key theoretical notions with several more mainstream psychoanalytic concepts. It further uses the notions of oneness, otherness, thirdness, and the fourth to consider the recent points of convergence between psychoanalysis and religion.

  10. Children's Books as a Source of Influence on Gender Role Development: Analysis of Female Characters Using Jung's Four Archetypes

    Science.gov (United States)

    Mills, Shirley J.; Pankake, Anita; Schall, Janine

    2010-01-01

    The purpose of the study was to answer this question: "Do children when choosing a book to read for pleasure receive a stereotypical impression of the female role as opposed to the male role as defined by the literature?" A qualitative study reviewed main female characters of the Children's Choice books of 2008 with Jung's archetypes (Great Good…

  11. Opicinus de Canistris: some notes from Jung's unpublished Eranos Seminar on the medieval Codex Palatinus Latinus 1993.

    Science.gov (United States)

    Quaglino, Gian Piero; Romano, Augusto; Bernardini, Riccardo

    2010-06-01

    Jung held an informal seminar for a limited number of students after the end of the Eranos Conference in August, 1943. All traces of this seminar were lost until the notes taken on it by one of the students, Alwine von Keller, were found in 2006. Jung's talk consisted of a psychological commentary on a series of images in the medieval Codex Palatinus Latinus 1993, attributed to Opicinus de Canistris (1296-c.1352), a fourteenth-century Italian clergyman, mystic, miniaturist, and cartographer. Jung interpreted Opicinus' images as a series of mandalas in which the Shadow, the dark principle, does not manage to be integrated into a balanced system. Opicinus tried to settle this division into opposites, which constitutes the main problem in modern times, while remaining inside the system of Christian doctrine. However, he did not succeed in his attempt to integrate the principle of the Shadow on the doctrinal level because he was not aware of the very same division in his own unconscious. Our article points out the features in the seminar where Jung seemed to show much more originality in his interpretation than other psychoanalytic studies on Opicinus or other analytical-psychological readings of medieval Christian art.

  12. Analytical comparison between Nixon-Logvinenko's and Jung-Brown's theories of slow neurofilament transport in axons.

    Science.gov (United States)

    Kuznetsov, I A; Kuznetsov, A V

    2013-10-01

    This paper develops analytical solutions describing slow neurofilament (NF) transport in axons. The obtained solutions are based on two theories of NF transport: Nixon-Logvinenko's theory that postulates that most NFs are incorporated into a stationary cross-linked network and only a small pool is slowly transported and Jung-Brown's theory that postulates a single dynamic pool of NFs that are transported according to the stop-and-go hypothesis. The simplest two-kinetic state version of the model developed by Jung and Brown was compared with the theory developed by Nixon and Logvinenko. The model for Nixon-Logvinenko's theory included stationary, pausing, and running NF populations while the model used for Jung-Brown's theory only included pausing and running NF populations. Distributions of NF concentrations resulting from Nixon-Logvinenko's and Jung-Brown's theories were compared. In previous publications, Brown and colleagues successfully incorporated slowing of NF transport into their model by assuming that some kinetic constants depend on the distance from the axon hillock. In this paper we defined the average rate of NF transport as the rate of motion of the center of mass of radiolabeled NFs. We have shown that for this definition, if all kinetic rates are assumed constant, Jung-Brown's theory predicts a constant average rate of NF transport. We also demonstrated that Nixon-Logvinenko's theory predicts slowing of NF transport even if all kinetic rates are assumed constant, and the obtained slowing agrees well with published experimental data. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Dual-aspect monism à la Pauli and Jung perforates the completeness of physics

    Science.gov (United States)

    Atmanspacher, Harald

    2012-12-01

    In the mid 19th century, the physicist Wolfgang Pauli and the psychologist Carl Gustav Jung developed a philosophical position for the mind-matter problem that is today called dual-aspect monism. They conjectured a picture in which the mental and the material arise as two complementary aspects of one underlying psychophysically neutral reality to which they cannot be reduced and to which direct empirical access is impossible. This picture suggests structural, persistent,re-producible mind-matter correlations by splitting the underlying reality into aspects. In addition, it suggests induced, occasional, evasive mind-matter correlations above and below, respectively, those stable baseline correlations. These correlations, and the way they arise, suggest that the domain of the physical is not completely independent of the domain of the mental, and both are not independent from the assumed reality underlying them. Some ideas are presented of how these relationships might be conceived.

  14. Relationship Between Personality Types Conceptualized by C. G. Jung and Emotional Intelligence

    Directory of Open Access Journals (Sweden)

    Natasha Virmozelova

    2013-10-01

    Full Text Available The main aim of this study is to present the results from a study of the relationship between personality types described by C. G. Jung and emotional intelligence. The investigated subjects were 150 at the age of 18 – 50. The methods of research were MBTI (Myers-Briggs Type Indicator - Bulgarian adaptation (Rusinova, 1992 and one psychological questionnaire measuring emotional intelligence -Bulgarian adaptation (Stoyanova, 2008. The received data indicated that the functions of thinking and sensing, and introversion correlated inversely with the factors of emotional intelligence “Sharing emotions and empathy”, “Motivation to overcome difficulties and optimisms” and extroversion correlated proportionally with them. The function feeling correlated proportionally with the factor “Sharing emotions and empathy” and it correlated inversely with the factor “Recognition of nonverbal expression of emotion of the other people”.

  15. From Freudian narcissism to the Buddhist notion of anatman, via Jung's idea of identity.

    Science.gov (United States)

    Martin-Vallas, François

    2017-02-01

    Starting from the question the youthful Carl Gustav pondered as he sat on 'his' stone - 'Am I he who sits on the stone, or am I the stone on which he sits?' - the author has attempted to show that, for Jung, the idea of identity is founded on a wilful non-determination. This stance results in ethical and methodological repercussions that differentiate it both from the Freudian project and from Hindu and Buddhist thought, while at the same time having much in common with them. The paper refers to the notions of emergence and (Varela et al. 1992) enaction and argues that the concept of the archetype, especially in relation to the self, merits a re-evaluation in light of the new scientific paradigm. © 2017, The Society of Analytical Psychology.

  16. Spin Crossover in Dinuclear N4S2 Iron(II) Thioether-Triazole Complexes: Access to [HS-HS], [HS-LS], and [LS-LS] States.

    Science.gov (United States)

    Hogue, Ross W; Feltham, Humphrey L C; Miller, Reece G; Brooker, Sally

    2016-05-01

    Access to a new family of thioether-linked PSRT ligands, 4-substituted-3,5-bis{[(2-pyridylmethyl)sulfanyl]methyl}-4H-1,2,4-triazoles (analogues of the previously studied amino-linked PMRT ligands), has been established. Four such ligands have been prepared, PSPhT, PS(i)BuT, PS(t-Bu)PhT, and PS(Me)PhT, with R = Ph, (i)Bu, (t-Bu)Ph, and (Me)Ph, respectively. Three dinuclear colorless to pale green iron(II) complexes, [Fe(II)2(PSRT)2](BF4)4·solvent, featuring N4S2 donor sets, were prepared. Single-crystal structure determinations on [Fe(II)2(PSPhT)2](BF4)4·2MeCN·H2O, [Fe(II)2(PSPhT)2](BF4)4·2(1)/2MeCN·(1)/2H2O·THF, [Fe(II)2(PS(Me)PhT)2](BF4)4·2MeCN, and [Fe(II)2(PS(i)BuT)2](BF4)4·4MeCN reveal that all four are stabilized in the [HS-HS] state to 100 K and that both possible binding modes of the bis-terdentate ligands, cis- and trans-axial, are observed. Variable-temperature magnetic susceptibility studies of air-dried crystals (solvatomorphs of the single crystal samples) reveal the first examples of spin crossover (SCO) for a dinuclear iron(II) complex with N4S2 coordination. Specifically, [Fe(II)2(PSPhT)2](BF4)4·2(1)/2H2O undergoes a multistep but complete SCO from [HS-HS] to [LS-LS], whereas [Fe(II)2(PS(Me)PhT)2](BF4)4·1(1)/2MeCN·2H2O exhibits a half-SCO from [HS-HS] to [HS-LS]. In contrast, [Fe(II)2(PS(i)BuT)2](BF4)4·MeCN·H2O remains [HS-HS] down to 50 K. The reflectance spectrum of pale green [Fe(II)2(PSPhT)2](BF4)4·(1)/2CHCl3·2(1)/2H2O (solvatomorph A) reveals a trace of LS character (572 nm band (1)A1g → (1)T1g). Evans' (1)H NMR method and UV-vis spectroscopy studies revealed that on cooling dark green acetonitrile solutions of these complexes from 313 to 233 K, all three undergo SCO centered at or near room temperature. The tendency of the complexes to go LS in solution reflects the electronic impact of R on the σ-donor strength of the PSRT ligand, whereas the opposite trend in stabilization of the LS state is seen in the solid state, where

  17. Developing competitive marketing and sales strategy for HS-Eden

    OpenAIRE

    Dragusha, Cajup

    2016-01-01

    Start-ups are faced with variety of challenges and uncertainty therefore comprehensive marketing and sales strategy must be in place to make sure that limited resources are spend wisely in order to minimize uncertainty and pave a path that would lead to successful business. HS Eden is a new-start-up venture created in Lappeenranta University of Technology with an ambition to develop AMB systems for commercial use. The aim of this study was to build a marketing and sales strategy to help HS-Ed...

  18. Narcissism, solitude, friendship: notes on the therapeutic alliance in the context of the Freud-Jung relationship.

    Science.gov (United States)

    Carta, Stefano

    2012-09-01

    This paper deals with friendship and therapeutic alliance as a transformation of the libidinal love that structures the Oedipal complex. The author considers the relationship between Jung and Freud as a formidable test that may shed light on their personalities and on the relevance of the Oedipal complex for both of them and for their particular theories and practices. The author discusses the possibility that the Oedipal complex may be seen under a finalistic frame of reference and discusses which implicit goals it may express. Such a goal has not been reached by either Freud nor Jung, but might be the key to underline and recognize the fundamental importance of the 'therapeutic alliance' within the analytical situation, seen as a potential relationship between the selves of the patient and of the analyst springing from a transformation of libidinal love into 'friendship' as it was described by Friedrich Nietzsche. © 2012, The Society of Analytical Psychology.

  19. [The spirit of art lives on the Essence of Poetry -from C. G. Jung to M. Heidegger].

    Science.gov (United States)

    Montironi, Jorge D

    2012-01-01

    Two major contemporary thinkers such as Carl Gustav Jung, Swiss physician who was born in 1875 and died in 1961 and Martin Heidegger, German philosopher born in 1889 and died in 1976, venture in their extensive research on art and poetry on two aspects which are the subjects of the spirit and the human essence and that for years, while pursuing in our work, under the name of the transmission unconscious poetry. Then we shall point out in this article the articulations we find, first deploying the key points of the magnificent work of Jung on The phenomenon of spirit in art and science and that developed by Heidegger in his lecture on Hölderlin and the Essence of Poetry.

  20. Jung's views on causes and treatments of schizophrenia in light of current trends in cognitive neuroscience and psychotherapy research I. Aetiology and phenomenology.

    Science.gov (United States)

    Silverstein, Steven M

    2014-02-01

    Jung's writings on schizophrenia are almost completely ignored or forgotten today. The purpose of this paper, along with a follow-up article, is to review the primary themes found in Jung's writings on schizophrenia, and to assess the validity of his theories about the disorder in light of our current knowledge base in the fields of psychopathology, cognitive neuroscience and psychotherapy research. In this article, five themes related to the aetiology and phenomenology of schizophrenia from Jung's writings are discussed:1) abaissement du niveau mental; 2) the complex; 3) mandala imagery; 4) constellation of archetypes and 5) psychological versus toxic aetiology. Reviews of the above areas suggest three conclusions. First, in many ways, Jung's ideas on schizophrenia anticipated much current thinking and data about the disorder. Second, with the recent (re)convergence of psychological and biological approaches to understanding and treating schizophrenia, the pioneering ideas of Jung regarding the importance of both factors and their interaction remain a useful and rich, but still underutilized resource. Finally, a more concerted effort to understand and evaluate the validity of Jung's concepts in terms of evidence from neuroscience could lead both to important advances in analytical psychology and to developments in therapeutic approaches that would extend beyond the treatment of schizophrenia.

  1. Measurement of Some Physiological and Biochemical Indexes of the Antisense Fragment of CYP86MF Gene Transgenic Male Sterile Plantlets in Chinese Cabbage-Pak-Choi

    Institute of Scientific and Technical Information of China (English)

    YU Xiao-lin; CAO Jia-shu; DONG De-kun

    2003-01-01

    In order to study the mechanism of the transgenic male sterility induced by the antisense fragment of gene CYP86MF, some physiological and biochemical indexes were compared between the transgenic plantlets of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) and their controls.Results showed that there was significant difference between content of the endogenous hormones in leaves and floral buds. GA3 contents in leaves of the transgenic plantlets of B. campestris L. ssp. chinensis Makino cv.Shanghai-qing and cv. Youqing were reduced by 31.72 and 46.88% respectively as compared with those of their controls, and GA3 contents in floral buds of them were reduced by 62.92 and 80.57 % respectively. In addition, ZT contents in leaves of cv. Shanghai-qing and cv. Youqing were reduced by 11.81 and 181.20%respectively as compared with those of their controls and those in floral buds were reduced by 105.94 and 128.75% respectively. But, ABA content in transgenic plantlets was significantly higher than that in nontransgenic plantlets. However, differences among respiratory rate and cyanide-resistant respiratory rate, the photosynthesic rate and the content of total flavones in floral buds were not significant. In this study, the results indicated that the gene CYP86MF might be one of the key functional genes to control fertility of Chinese cabbage.

  2. Jung in education: a review of historical and contemporary contributions from analytical psychology to the field of education.

    Science.gov (United States)

    Gitz-Johansen, Thomas

    2016-06-01

    The available literature on the influence of Jungian thought on the theory and practice of education leaves the impression that although the work of Carl Jung and analytical psychology have much to offer the field of education, the Jungian influence has so far been slight. While this has certainly been true, the last decade or so has nevertheless witnessed an increased scholarly interest in exploring how analytical psychology may inform and inspire the field of education. As an explanation for this burgeoning interest in Jung, several of the contemporary contributors mention that analytical psychology has the potential of functioning as a counterbalance to the tendencies in Western societies to focus on measurable learning targets and increasingly standardized measures of teaching and assessment. It seems pertinent then to gain an overview of how analytical psychology has so far inspired the field of education and how it may fruitfully continue do so in the future. To this end this paper is structured chronologically, starting with the different phases of Jung's own engagement with the field of education and ending with later post-Jungian applications of his concepts and ideas to education. © 2016, The Society of Analytical Psychology.

  3. Molecular Analysis of HS-111 and 3`HS1 Variations in β-Thalassemia Intermedia Patients with High Levels of HbF

    Directory of Open Access Journals (Sweden)

    Mohammad Hamid

    2010-01-01

    Full Text Available Objective: To study the possible association between high levels of fetal haemoglobin(HbF in β-thalassemia intermedia patients and HS-111 and 3`HS1 sequence variations.Materials and Methods: In this study, the 3' HS-1 and HS-111 regions of 30 ß-thalassaemiaintermedia patients (ß°/ß° with high levels of HbF, 21 ß-thalassemia major patientsand 40 normal Iranian individuals were analyzed by single-strand conformation polymorphism(SSCP and polymerase chain reaction (PCR sequencing.Results: Two nucleotide variations in 3' HS111 (-21A>G and 3`HS1 (179C>T wereidentified. The most frequent sequence variation was 3' HS111 (-21A in the intermediapatients and 3`HS111 (-21G in the major thalassemia patients. In contrast to the 3`HS1marker, both 3'HS111 A and G variants showed a correlation with each studied group.Conclusion: The HS111 marker in conjunction with other parameters could be used asappropriate genetic markers to discriminate β-thalassemia intermedia patients (β°/β° withhigh levels of HbF from β-thalassemia major patients.

  4. High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate.

    Science.gov (United States)

    Wiesner, Melanie; Schreiner, Monika; Glatt, Hansruedi

    2014-05-01

    Cruciferous vegetables have the reputation to protect against cancer, an effect attributed to glucosinolates (GLS) and their breakdown products. However, some GLS are mutagenic, an activity associated with cancer initiation rather than chemoprevention. We show that juices from steamed pak choi sprouts are strongly mutagenic in Salmonella typhimurium TA100 upon addition of fresh myrosinase. Growth of the plants in the presence of methyl jasmonate, a hormone eliciting defence factors, led to 20-fold enhanced mutagenic activity. The level of 1-methoxy-3-indolylmethyl (1-MIM)-GLS was similarly increased, whereas those of other GLS were only elevated 0.8- to 3.2-fold. 1-MIM-GLS is a potent mutagen, whose activity is further enhanced by human sulphotransferase 1A1 (hSULT1A1), an activation not observed with other GLS. The mutagenicity of the pak choi juices was increased 20-fold in bacteria expressing hSULT1A1. A tiny level of juice from elicitated sprouts, 0.04% in the mutagenicity assay, was sufficient to double the number of revertants above the spontaneous level. We conclude that pak choi juice is mutagenic, an activity that can be strongly affected by the growth conditions. It is owed essentially to a single component, 1-MIM-GLS. We recommend using cultivars, growth conditions and/or food preparations that keep the level of this GLS congener low.

  5. Jónsson and HS Modules over Commutative Rings

    Directory of Open Access Journals (Sweden)

    Greg Oman

    2014-01-01

    Full Text Available Let R be a commutative ring with identity and let M be an infinite unitary R-module. (Unless indicated otherwise, all rings are commutative with identity 1≠0 and all modules are unitary. Then M is called a Jónsson module provided every proper submodule of M has smaller cardinality than M. Dually, M is said to be homomorphically smaller (HS for short if |M/N|<|M| for every nonzero submodule N of M. In this survey paper, we bring the reader up to speed on current research on these structures by presenting the principal results on Jónsson and HS modules. We conclude the paper with several open problems.

  6. High-speed Neural Network HS-K-WTA-2%高速神经网络HS-K-WTA-2的研究

    Institute of Scientific and Technical Information of China (English)

    朱红; 陈清华; 刘国岁

    2007-01-01

    该文提出了一种新的K-Winners-Take-All神经网络:High-Speed-K-Winners-Take-All-2(HS-K-WTA-2).HS-K-WTA-2以竞争学习算法为基础.HS-K-WTA-2能够从任何一个数集中识别出K个较大的数,或K个较小的数.该文给出HS-K-WTA-2算法及算法复杂度的分析结果.用专门为研究K-WTA神经网络开发的仿真程序对HS-K-WTA-2、HS-K-WTA和Winstrons进行仿真研究.结果显示:当所取的数集N较大时,HS-K-WTA-2要比Winstrons和HS-K-WTA速度更快.HS-K-WTA-2的硬件实现比Winston的硬件实现要简单,比HS-K-WTA的硬件实现复杂.

  7. EEG-Based Brain-Computer Interface for Decoding Motor Imagery Tasks within the Same Hand Using Choi-Williams Time-Frequency Distribution

    Directory of Open Access Journals (Sweden)

    Rami Alazrai

    2017-08-01

    Full Text Available This paper presents an EEG-based brain-computer interface system for classifying eleven motor imagery (MI tasks within the same hand. The proposed system utilizes the Choi-Williams time-frequency distribution (CWD to construct a time-frequency representation (TFR of the EEG signals. The constructed TFR is used to extract five categories of time-frequency features (TFFs. The TFFs are processed using a hierarchical classification model to identify the MI task encapsulated within the EEG signals. To evaluate the performance of the proposed approach, EEG data were recorded for eighteen intact subjects and four amputated subjects while imagining to perform each of the eleven hand MI tasks. Two performance evaluation analyses, namely channel- and TFF-based analyses, are conducted to identify the best subset of EEG channels and the TFFs category, respectively, that enable the highest classification accuracy between the MI tasks. In each evaluation analysis, the hierarchical classification model is trained using two training procedures, namely subject-dependent and subject-independent procedures. These two training procedures quantify the capability of the proposed approach to capture both intra- and inter-personal variations in the EEG signals for different MI tasks within the same hand. The results demonstrate the efficacy of the approach for classifying the MI tasks within the same hand. In particular, the classification accuracies obtained for the intact and amputated subjects are as high as 88 . 8 % and 90 . 2 % , respectively, for the subject-dependent training procedure, and 80 . 8 % and 87 . 8 % , respectively, for the subject-independent training procedure. These results suggest the feasibility of applying the proposed approach to control dexterous prosthetic hands, which can be of great benefit for individuals suffering from hand amputations.

  8. EEG-Based Brain-Computer Interface for Decoding Motor Imagery Tasks within the Same Hand Using Choi-Williams Time-Frequency Distribution

    Science.gov (United States)

    Alwanni, Hisham; Baslan, Yara; Alnuman, Nasim; Daoud, Mohammad I.

    2017-01-01

    This paper presents an EEG-based brain-computer interface system for classifying eleven motor imagery (MI) tasks within the same hand. The proposed system utilizes the Choi-Williams time-frequency distribution (CWD) to construct a time-frequency representation (TFR) of the EEG signals. The constructed TFR is used to extract five categories of time-frequency features (TFFs). The TFFs are processed using a hierarchical classification model to identify the MI task encapsulated within the EEG signals. To evaluate the performance of the proposed approach, EEG data were recorded for eighteen intact subjects and four amputated subjects while imagining to perform each of the eleven hand MI tasks. Two performance evaluation analyses, namely channel- and TFF-based analyses, are conducted to identify the best subset of EEG channels and the TFFs category, respectively, that enable the highest classification accuracy between the MI tasks. In each evaluation analysis, the hierarchical classification model is trained using two training procedures, namely subject-dependent and subject-independent procedures. These two training procedures quantify the capability of the proposed approach to capture both intra- and inter-personal variations in the EEG signals for different MI tasks within the same hand. The results demonstrate the efficacy of the approach for classifying the MI tasks within the same hand. In particular, the classification accuracies obtained for the intact and amputated subjects are as high as 88.8% and 90.2%, respectively, for the subject-dependent training procedure, and 80.8% and 87.8%, respectively, for the subject-independent training procedure. These results suggest the feasibility of applying the proposed approach to control dexterous prosthetic hands, which can be of great benefit for individuals suffering from hand amputations. PMID:28832513

  9. Cloning and Characterization of the Microspore Development-Related Gene BcMF2 in Chinese Cabbage Pak-Choi (Brassica campestris L. ssp. chinensis Makino)

    Institute of Scientific and Technical Information of China (English)

    Yong-Qin WANG; Wan-Zhi YE; Jia-Shu CAO; Xiao-Lin YU; Xun XIANG; Gang LU

    2005-01-01

    For the sake of providing some important information relevant to the study of the molecular mechanism of genic male sterility in plants, gene differential expression in flower buds at different developmental stages, as well as in rosette leaves, florescence leaves, and scapes was analyzed using cDNA amplified fragment length polymorphism (cDNA-AFLP) in the genic male sterile A and fertile B line of Chinese cabbage pak-choi. Following amplification of 125 pairs of primer combinations, 11 differential fragments were obtained, of which eight were from the B line and the other three were from the A line. Of 11 differential fragments, four were verified by Northern hybridization that were expressed preferentially in fertile flower buds. Results of GenBank BLAST showed that one fragment was with unknown function,whereas the other fragments have strong nucleotide sequence similarities with the polygalacturonase (PG)gene, the pectinesterase (PE) gene, and the polygalacturonase inhibitory protein (PGIP4) gene. Only fulllength cDNA from the differential fragment BcMF-A18T16-1 was amplified by rapid amplification of cDNA ends (RACE) and Northern analysis showed that this fragment was expressed only in medium and largesized flower buds of the B line. The full-length cDNA, designated as BcMF2 (Brassica campestris Male Fertile 2), was 1 485 bp long and was composed of a 1 263-bp open reading frame, which had 83% nucleotide similarity to a PG gene from Arabidopsis encoding polygalacturonase. Analysis of the basic structure of the protein revealed that it had one polygalacturonase active site (RVTCGPGHGLSVGS) at 256th site of amino acids and was classified as being a member of family 28 of the glycosyl hydrolases. The role of the BcMF2 gene on microspore development is discussed in the present paper.

  10. High Speed Oblivious Random Access Memory (HS-ORAM)

    Science.gov (United States)

    2015-09-01

    and Automated Teller Machines ( ATM ) security while generally impractical due to performance limitations and high acquisition costs. This idea has...HIGH SPEED OBLIVIOUS RANDOM ACCESS MEMORY (HS-ORAM) PRIVATE MACHINES , INC. SEPTEMBER 2015 FINAL TECHNICAL REPORT...UNIT NUMBER I1 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Private Machines Inc. 164 20th Street #3D Brooklyn, NY 11232 8. PERFORMING

  11. File list: Oth.Epd.05.AllAg.Hs_68 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Epd.05.AllAg.Hs_68 hg19 TFs and others Epidermis Hs 68 SRX396584,SRX396581,SRX3...96579,SRX396580,SRX396583,SRX396590,SRX396589 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Epd.05.AllAg.Hs_68.bed ...

  12. File list: NoD.Epd.50.AllAg.Hs_68 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Epd.50.AllAg.Hs_68 hg19 No description Epidermis Hs 68 SRX007038,SRX007037,SRX0...07036,SRX007035 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Epd.50.AllAg.Hs_68.bed ...

  13. File list: NoD.Epd.10.AllAg.Hs_68 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Epd.10.AllAg.Hs_68 hg19 No description Epidermis Hs 68 SRX007036,SRX007035,SRX0...07038,SRX007037 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Epd.10.AllAg.Hs_68.bed ...

  14. File list: NoD.Epd.20.AllAg.Hs_68 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Epd.20.AllAg.Hs_68 hg19 No description Epidermis Hs 68 SRX007036,SRX007038,SRX0...07037,SRX007035 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Epd.20.AllAg.Hs_68.bed ...

  15. Method development and analysis of free HS and HS in proteoglycans from pre- and postmenopausal women: evidence for biosynthetic pathway changes in sulfotransferase and sulfatase enzymes.

    Science.gov (United States)

    Wei, Wei; Miller, Rebecca L; Leary, Julie A

    2013-06-18

    Heparan sulfate (HS) is one of the most complex and informative biopolymers found on the cell surface or in the extracellular matrix as either free HS fragments or constituents of HS proteoglycans (HSPGs). Analysis of free HS and HSPG sugar chains in human serum at the disaccharide level has great potential for early disease diagnosis and prognosis; however, the low concentration of HS in human serum, together with the complexity of the serum matrix, limits the information on HS. In this study, we present and validate the development of a new sensitive method for in-depth compositional analysis of free HS and HSPG sugar chains. This protocol involved several steps including weak anion exchange chromatography, ultrafiltration, and solid-phase extraction for enhanced detection prior to LC-MS/MS analysis. Using this protocol, a total of 51 serum samples from 26 premenopausal and 25 postmenopausal women were analyzed. Statistically significant differences in heparin/HS disaccharide profiles were observed. The proportion of N-acetylation and N-sulfation in both free HS and HSPG sugar chains were significantly different between pre- and postmenopausal women, indicating changes in N-deacetylase/N-sulfotransferases (NDSTs), the enzymes involved in the initial step of the biosynthetic pathway. Differences in the proportion of 6-O-sulfation suggest that 6-O-sulfotransferase and/or 6-O-sulfatase enzymes may also be implicated.

  16. Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.

    Science.gov (United States)

    Ley, T J; Hug, B; Fiering, S; Epner, E; Bender, M A; Groudine, M

    1998-06-30

    To gain insights into the functions of individual DNA'se hypersensitive sites within the beta globin locus control region (LCR), we deleted the endogenous 5' HS-2 and HS-3 regions from the mouse germline using homologous recombination techniques. We demonstrated that the deletion of either murine 5' HS-2 or 5' HS-3 reduced the expression of the embryonic epsilon y and beta h1 globin genes minimally in yolk sac-derived erythrocytes, but that both knockouts reduced the output of the adult beta (beta-Major + beta-Minor) globin genes by approximately 30% in adult erythrocytes. When the selectable marker PGK-Neo cassette was retained within either the HS-2 or HS-3 region, a much more severe reduction in globin gene expression was observed at all developmental stages. PGK-Neo was shown to be expressed in an erythroid-specific fashion when it was retained in the HS-3 position. These results show that neither 5' HS-2 nor HS-3 is required for the activity of embryonic globin genes, nor are these sites required for correct developmental switching. However, each site is required for approximately 30% of the total LCR activity associated with adult beta-globin gene expression in adult red blood cells. Each site therefore contains some non-redundant information that contributes to adult globin gene function.

  17. Occupy als Jugendbewegung für Generationengerechtigkeit?: Mediatisierte Aushandlungen des ‚Politischen‘ durch junge Menschen

    Directory of Open Access Journals (Sweden)

    Stehling, Miriam

    2015-08-01

    Full Text Available Ausgehend von der Debatte um eine ‚Politikverdrossenheit‘ der Jugend diskutiert der Artikel, welche Bedeutung Generationengerechtigkeit bei den Occupy-Protesten zukommt. Vor dem Hintergrund eines erweiterten Begriffs des ‚Politischen‘ wird zum einen argumentiert, dass junge Menschen gegenwärtig in einen Bereich neuartiger Politikformen und Praktiken eingebunden sind, der eng mit der Omnipräsenz digitaler Medien verknüpft ist. Zum anderen wird herausgearbeitet, wie Medien bei den Occupy-Protesten genutzt werden, um Forderungen nach sozialer Gerechtigkeit zu artikulieren.

  18. La Reina de las Nieves. La moral y el inconsciente : Leonardo Villalba según Sigmund Freud y Carl Jung

    OpenAIRE

    Nicolás, Maite

    2016-01-01

    Esta tesina trata sobre la moral y el inconsciente a partir del análisis del personaje Leonardo Villalba de la novela La Reina de las Nieves, escrita por Carmen Martín Gaite. El estudio se hace a partir de las siguientes teorías: inconsciente de Sigmund Freud; ello, yo y superyó de Sigmund Freud; inconsciente de Carl Jung. La información almacenada en el inconsciente de una persona es algo que ésta no puede contar ya que ella misma no sabe que tiene tal información. Así, al ser Leonardo narra...

  19. Twin Concept of Fine Structure Constant as the ‘Self Number-Archetype’ in Perspective of the Pauli-Jung Correspondence; Part I: Observation, Identification and Interpretation

    Directory of Open Access Journals (Sweden)

    Péter Várlaki

    2009-07-01

    Full Text Available The paper – similarly to our earlier publications since 1993 – is trying to‘synchronize’ early quantum physics, the Kalmanian representation theory, Jungiananalytic psychology, and certain aesthetical categories. The number ‘137’, the so-calledinverse Fine Structure Constant (IFSC, is placed at the centre of this heuristic andepistemological experiment, along with the scientific cooperation of Pauli and Jung. A newpossibilistic twin concept of “controlling-observing equations” is proposed for thereinterpretation of the FSC and other Number Archetypes on the basis of the Hermeneuticand symbolic languages found in the W. Pauli and C. G. Jung “Correspondence”. The firstpart of the paper deals in first line with the introduction of the possibilistic twin concept ofFSC together with its interpretation according to the hermeneutical “tradition” of thePauli-Jung collaboration.

  20. Neural-Based Cuckoo Search of Employee Health and Safety (HS

    Directory of Open Access Journals (Sweden)

    Koffka Khan

    2013-01-01

    Full Text Available A study using the cuckoo search algorithm to evaluate the effects of using computer-aided workstations on employee health and safety (HS is conducted. We collected data for HS risk on employees at their workplaces, analyzed the data and proposed corrective measures applying our methodology. It includes a checklist with nine HS dimensions: work organization, displays, input devices, furniture, work space, environment, software, health hazards and satisfaction. By the checklist, data on HS risk factors are collected. For the calculation of an HS risk index a neural-swarm cuckoo search (NSCS algorithm has been employed. Based on the HS risk index, IHS four groups of HS risk severity are determined: low, moderate, high and extreme HS risk. By this index HS problems are allocated and corrective measures can be applied. This approach is illustrated and validated by a case study. An important advantage of the approach is its easy use and HS index methodology speedily pointing out individual employee specific HS risk.

  1. Nonexistence of Weyl-Heisenberg Frame on Sobolev Space Hs(Rd)%Sobolev 空间Hs(Rd)上的Weyl-Heisenberg框架的不存在性

    Institute of Scientific and Technical Information of China (English)

    李锐; 郝祥晖; 李登峰

    2002-01-01

    研究在窗函数的Fourier变换具有紧支集条件下,Sobolev空间Hs(Rd)上不存在Weyl-Heisenberg框架.这个结果表明:对Sobolev空间Hs(Rd)上的Weyl-Heisenberg框架的研究意义不大.

  2. Recovery from a Financial Meltdown: The Political Economy of Crisis Management under the Kim Dae-Jung Administration

    Directory of Open Access Journals (Sweden)

    Shalendra D. Sharma

    2002-12-01

    Full Text Available In Korea, the IMF-supported program, approved in late 1997, focused on financial sector restructuring, corporate governance, capital account liberalization, labor market reforms and trade liberalization. As in Thailand, it soon became clear that the IMF program underestimated the severity and deIn Korea, the IMF-supported program, approved in late 1997, focused on financial sector restructuring, corporate governance, capital account liberalization, labor market reforms and trade liberalization. As in Thailand, it soon became clear that the IMF program underestimated the severity and depth of the crisis. It fell upon the newly-elected government of Kim Dae-Jung to deal with both the crisis and the IMF. This paper illustrates how the Kim Dae-Jung administration deftly dealt with the grave challenges it faced. Korea's remarkable economic recovery, is in large measure, due to the government's prudent handling of the numerous economic challenges it faced. This paper examines the Korean government's management of the crisis-documenting both its achievements and the challenges ahead.

  3. 血清NT-proBNP、hs-TnT及hs-CRP水平与急性心肌梗死的相关性研究%Correlation between serum NT-proBNP, hs-TnT and hs-CRP levels and acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    符明昌; 周莲; 羊文芳; 苏显都

    2016-01-01

    目的:探讨血清脑钠肽前体(NT-proBNP)、高敏肌钙蛋白T (hs-TnT)、超敏C反应蛋白(hs-CRP)与急性心肌梗死(AMI)的相关性,并分析联合检测对AMI患者的诊断价值。方法选取2013年1月至2015年6月海南省第三人民医院112例AMI患者和80例体检者(对照组),分别检测AMI患者3 h、12 h、1 d、3 d、7 d血清NT-proBNP、hs-TnT及hs-CRP水平,并与对照组进行比较。绘制受试工作特征曲线(ROC)评价NT-proBNP、hs-TnT及hs-CRP在AMI中的诊断价值,并应用Logistic回归模型分析AMI的独立危险因素。结果 AMI组血清NT-proBNP、hs-TnT及hs-CRP水平明显高于对照组,差异均有统计学意义(P<0.05)。血清NT-proBNP、Hs-TnT及Hs-CRP在AMI患者中出现峰值时间分别为1 d、12 h、3 d。应用Logistic回归模型对变量进行单因素及多因素分析,发现NT-proBNP、hs-TnT及hs-CRP是发生AMI的独立危险因素,其OR值及95%CI分别为1.012(0.874~1.136)、1.350(1.026~1.724)、1.168(1.014~1.337)。ROC曲线显示,NT-proBNP、hs-TnT、hs-CRP和三项联合检测的AUC及95%CI分别为:0.860(0.784~0.975)、0.834(0.762~0.905)、0.748(0.668~0.817)、0.885(0.794~0.971)。Spearman相关分析显示,NT-proBNP与hs-TnT呈明显正相关(r=0.679,P<0.05),NT-proBNP与hs-CRP呈明显正相关(r=0.602,P<0.05),hs-TnT与hs-CRP呈明显正相关(r=0.568,P<0.05)。结论 NT-proBNP、hs-TnT及hs-CRP是AMI发生的独立预测因子,联合检测可提高AMI诊断的准确性,有助于早期治疗并改善预后。%Objective To investigate the diagnostic value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT) and hypersensitive C-reactive protein (hs-CRP) in acute myocardial infarction (AMI), and to analyze their correlation. Methods A total of 112 patients of AMI (AMI group) and 80 sub-jects of physical examination (control group) in Third People's Hospital of Hainan Province were selected from January

  4. Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment.

    Science.gov (United States)

    Uyanik, Vesile; Tuglu, Cengiz; Gorgulu, Yasemin; Kunduracilar, Hakan; Uyanik, Mehmet Sevki

    2015-08-30

    We aimed to assess the relationship between cytokine levels and the severity of the manic period in medication free patients. 30 Medication free patients and 28 healthy subjects (HS) were recruited. Plasma levels of pro-inflammatory, anti-inflammatory, inflammatory cytokines, and hs-CRP levels were investigated upon hospital admission, after six weeks follow up in bipolar disease manic episode and the results were compared to HS. The severity of the manic episodes was assessed according to the Young mania rating scale. TNF-α, INF-γ, IL-6 and hs-CRP levels were significantly higher in patients with manic episode of bipolar I disorder before treatment than HS. After treatment the levels of TNF-α, INF-γ, IL-6 and hs-CRP were observed to be significantly decreased. There was no difference between the levels of anti-inflammatory cytokines in patients before or after treatment of bipolar disorder and HS. hs-CRP was observed to be the only parameter correlated with clinical response. The most significant outcome of this study is the correlation between clinical outcome and hs-CRP levels in treatment naive manic episode bipolar type I patients. hs-CRP is the most consistent indicator according to pro-inflammatory, inflammatory and anti-inflammatory cytokines, in predicting treatment outcomes.

  5. N=2 gauge theories on the hemisphere $HS^4$

    CERN Document Server

    Gava, Edi; Muteeb, Nouman; Giraldo-Rivera, V I

    2016-01-01

    Using localization techniques, we compute the path integral of $N=2$ SUSY gauge theory coupled to matter on the hemisphere $HS^4$, with either Dirichlet or Neumann supersymmetric boundary conditions. The resulting quantities are wave-functions of the theory depending on the boundary data. The one-loop determinant are computed using $SO(4)$ harmonics basis. We solve kernel and co-kernel equations for the relevant differential operators arising from gauge and matter localizing actions. The second method utilizes full $SO(5)$ harmonics to reduce the computation to evaluating $Q_{SUSY}^2$ eigenvalues and its multiplicities. In the Dirichlet case, we show how to glue two wave-functions to get back the partition function of round $S^4$. We will also describe how to obtain the same results using $SO(5)$ harmonics basis.

  6. 3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.

    NARCIS (Netherlands)

    Dam, G.B. ten; Kurup, S.; Westerlo, E.M. van de; Versteeg, E.M.M.; Lindahl, U.; Spillmann, D.; Kuppevelt, A.H.M.S.M. van

    2006-01-01

    Antibodies against heparan sulfate (HS) are useful tools to study the structural diversity of HS. They demonstrate the large sequential variation within HS and show the distribution of HS oligosaccharide sequences within their natural environment. We analyzed the distribution and the structural char

  7. Analytisch-psychologische conceptualisatie van het symbolische bij C.G. Jung : Onderzoek van het statuut daarvan in een bekend Westers esoterisch genootschap: de Vrijmetselarij

    NARCIS (Netherlands)

    M.M.J. Journee

    1999-01-01

    textabstractDe Analytische Psychologie en de Vrijmetselarij zijn twee relatief onbekende fenomenen. Dit proefschrift onderzoekt of de symbolen, riten en mythen van de Vrijmetselarij verklaard kunnen worden vanuit de Analytische Psychologie van Carl Gustav Jung. "Symbolen, riten en mythen noemen we h

  8. Freud's Therapeutic Mistake with Jung's Disclosure of Childhood Sexual Abuse: Narrative Lessons in the Do's and Don'ts of Validation.

    Science.gov (United States)

    Gasker, Janice

    1999-01-01

    Examines the life narratives of over 25 "victims" and "survivors" of sexual victimization, including that of Carl Jung, as revealed in his letters to Sigmund Freud. Looks at the devastating results of Freud's invalidating response. Discusses categories of successful therapeutic validation. (SR)

  9. Jung's views on causes and treatments of schizophrenia in light of current trends in cognitive neuroscience and psychotherapy research II: psychological research and treatment.

    Science.gov (United States)

    Silverstein, Steven M

    2014-04-01

    Jung was the first to emphasize the importance of psychological factors in the aetiology and treatment of schizophrenia. Despite this, and other seminal contributions, his work on schizophrenia is almost completely ignored or forgotten today. This paper, a follow-up to one on Jung's theories of aetiology and symptom formation in schizophrenia (Journal of Analytical Psychology, 59, 1) reviews Jung's views on psychological approaches to research on, and treatment of, the disorder. Five themes are covered: 1) experimental psychopathology; 2) attentional disturbance; 3) psychological treatment; 4) the relationship between the environment (including the psychiatric hospital) and symptom expression; and 5) heterogeneity and the schizophrenia spectrum. Review of these areas reveal that Jung's ideas about the kind of research that can elucidate psychological mechanisms in schizophrenia, and the importance of psychotherapy for people with this condition, are very much in line with contemporary paradigms. Moreover, further exploration of several points of convergence could lead to advances in both of these fields, as well as within analytical psychology.

  10. Freud's Therapeutic Mistake with Jung's Disclosure of Childhood Sexual Abuse: Narrative Lessons in the Do's and Don'ts of Validation.

    Science.gov (United States)

    Gasker, Janice

    1999-01-01

    Examines the life narratives of over 25 "victims" and "survivors" of sexual victimization, including that of Carl Jung, as revealed in his letters to Sigmund Freud. Looks at the devastating results of Freud's invalidating response. Discusses categories of successful therapeutic validation. (SR)

  11. Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness

    OpenAIRE

    Liao, Huocheng; Li, Zhiming; Zheng, Dongdan; Liu, Jianping; Liu, Yan; Xiao, Chun; Wang, Hongguang

    2014-01-01

    Background High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression. Method One hundred sixty consecutive participants underwent carotid intima-media thickness (CIMT) measured by ultrasound were enrolled and drawn fasting blood samples for plasma l...

  12. Kadar hs-CRP pada pasien DM tipe 2 Dengan dan Tanpa Hipertensi

    OpenAIRE

    Ramadhani, Efi

    2016-01-01

    Introduction: More than 50% of patients with type-2 diabetes have hypertension. Hypertension contributes the development of cardiovascular disease. hs-CRP is an inflammation marker which is associated with cardiovascular risk. The aim of this study is to measure hs-CRP in type-2 diabetes with and without hypertension and to assess hs-CRP levels based on cardiovascular risk group. Methods: This study is an analytical observational cross-sectional study. Performed at the Department of Clini...

  13. The possible existence of Hs in nature from a geochemical point of view

    CERN Document Server

    Ivanov, A V

    2006-01-01

    A hypothesis of the existence of a long-lived isotope 271Hs in natural molybdenites and osmirides is considered from a geochemical point of view. It is shown that the presence of Hs in these minerals can be explained only by making an additional ad hoc assumption on the existence of an isobaric pair of 271Bh-271Hs. This assumption could be tested by mass-spectrometric measurements of U, Pb, Kr, Xe, and Zr isotopic shifts.

  14. Hcy与hs-CRP测定在CHD诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    李林

    2009-01-01

    @@ 越来越多的研究表明,同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)是动脉粥样硬化独立的危险因素[1~2].本文通过检测冠心病(CHD)患者与对照组血中的Hcy、hs-CRP水平,探讨CHD的严重程度与Hcy、hs-CRP的相关性.

  15. Component C of the methylcoenzyme M methylreductase system contains bound 7-mercaptoheptanoylthreonine phosphate (HS-HTP).

    Science.gov (United States)

    Noll, K M; Wolfe, R S

    1986-09-30

    The structure of component B of the methylcoenzyme M methylreductase system of Methanobacterium thermoautotrophicum was recently found to be 7-mercaptoheptanoylthreonine phosphate (HS-HTP). The work described here demonstrates that this compound is found in two forms: enzyme-free and enzyme-bound. HS-HTP was found to be bound to component C of the methylcoenzyme M methylreductase system. The cofactor extracted from the protein by heat denaturation was found to comigrate with the mixed disulfide of HS-HTP and 2-mercaptoethanol by high-performance liquid chromatography, suggesting HS-HTP is not modified in the bound state.

  16. Synchronicité le rapport entre physique et psyché de Pauli et Jung à Chopra

    CERN Document Server

    Teodorani, Massimo

    2015-01-01

    De mystérieux événements synchrones semblent parsemer nos vies. Tandis qu'une pensée affleure, un fait, qui renferme toujours un sens profond dont le but est de conduire nos vies vers leur destin, se produit à l'improviste, dans un synchronisme parfait. L'objectif de ce livre est de démontrer que le phénomène de la « synchronicité » est depuis longtemps étudié, en particulier par les physiciens quantiques. Ces recherches plongent leurs racines dans l'alliance durable et harmonieuse entre le grand psychologue analytique Carl Gustav Jung et le physicien quantique Wolfgang Pauli.

  17. Jung's archetype, 'The Wounded Healer', mental illness in the medical profession and the role of the health humanities in psychiatry.

    Science.gov (United States)

    Hankir, Ahmed; Zaman, Rashid

    2013-07-12

    Carl Jung used the term, 'The Wounded Healer' as an archetype to describe doctors who have suffered from an illness. Reading and writing autobiographical narratives of the 'Wounded Healer' is gaining popularity among doctors with mental illness as an effective form of adjunctive therapy. Moreover, reading autobiographical narratives of psychopathology sufferers can 'augment' service providers' humanity by offering valuable qualitative insights into minds afflicted with a psychiatric disorder. The primary author, a doctor of Middle-Eastern descent practicing in the UK, composed an autobiographical narrative about his personal experiences with oscillations in his mood in an attempt to illustrate the cultural, religious and psychosocial factors that influence disease detection, progression, treatment and outcome. An inordinate amount of misconceptions about mental illness abound. We hope that this manuscript will help to lessen the stigma associated with those who suffer from psychopathology (particularly doctors) and encourage sufferers to engage with the appropriate services.

  18. In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.

    Science.gov (United States)

    Bébin, Anne-Gaëlle; Carrion, Claire; Marquet, Marie; Cogné, Nadine; Lecardeur, Sandrine; Cogné, Michel; Pinaud, Eric

    2010-04-01

    In the mouse, the regulatory region located at the 3' end of the IgH locus includes four transcriptional enhancers: HS3a, HS1-2, HS3b, and HS4; the first three lie in a quasi-palindromic structure. Although the upstream elements HS3a and HS1-2 proved dispensable for Ig expression and class switch recombination (CSR), the joint deletion of HS3b and HS4 led to a consistent decrease in IgH expression in resting B cells and to a major CSR defect. Within this pair of distal enhancers, it was questionable whether HS3b and HS4 could be considered individually as elements critical for IgH expression and/or CSR. Studies in HS4-deficient mice recently revealed the role of HS4 as restricted to Igmicro-chain expression from the pre-B to the mature B cell stage and left HS3b as the last candidate for CSR regulation. Our present study finally invalidates the hypothesis that CSR could mostly rely on HS3b itself. B cells from HS3b-deficient animals undergo normal proliferation, germline transcription, and CSR upon in vitro stimulation with LPS; in vivo Ag-specific responses are not affected. In conclusion, our study highlights a major effect of the global ambiance of the IgH locus; enhancers demonstrated as being strongly synergistic in transgenes turn out to be redundant in their endogenous context.

  19. Sistem Informasi Penjualan Pemasangan Kacafilm “HS Auto Film"

    Directory of Open Access Journals (Sweden)

    Noer Tjahja Moekthi Pratjitana

    2013-07-01

    Full Text Available The growing market share in many business areas especially in service area is causing the use of conventional accounting system being ineffective. One of the companies which still using the conventional one is a window film set-up service company called HS Auto Film. The process of processing sales data is less accurate and slower in the contrary of the developing sales data.  Computer-based window film set-up Sales Information System is built in order to make the processing data more accurate and faster.  The information system is built using Visual Basic programming language along with .NET framework technology and SQL Server database that embedded in the application itself. The making and development process of the Sales Information System is using waterfall method.  Waterfall method consists of user requirement, analysis, design, implementation, and testing. Entity Relationship Diagram, Data Flow Diagram and Flowchart are also used in the Information System design. The output of this application design is a desktop application that can help user to control the set-up of window film, manage payment bill, and manage document in accounting in faster and more accurate way. The information system can be developed later using web-based system so that the development and maintenance can be done easier.

  20. Complete genomic sequence of campylobacter jejuni subsp. jejuni HS:19 penner reference strain

    Science.gov (United States)

    Campylobacter jejuni subsp. jejuni (Cjj) infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Capsular type Penner HS:19 is among several capsule types shown to be markers for GBS. This study describes the genome of Cjj HS:19...

  1. Genomic Sequence of Campylobacter jejuni subsp. jejuni HS:19 Penner Serotype Reference Strain RM3420

    Science.gov (United States)

    Huynh, Steven; Heikema, Astrid P.

    2017-01-01

    ABSTRACT Campylobacter jejuni subsp. jejuni infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Penner serotype HS:19 is among several capsular types shown to be markers for GBS. This study describes the genome of C. jejuni subsp. jejuni HS:19 Penner reference strain RM3420. PMID:28232429

  2. Vegetable and Fruit Intakes Are Associated with hs-CRP Levels in Pre-Pubertal Girls.

    Science.gov (United States)

    Navarro, Pilar; de Dios, Olaya; Jois, Asha; Gavela-Pérez, Teresa; Gorgojo, Lydia; Martín-Moreno, José M; Soriano-Guillen, Leandro; Garcés, Carmen

    2017-03-02

    The influence of diet on inflammation in children remains unclear. We aimed to analyze the influence of diet on high-sensitivity C-reactive protein (hs-CRP) levels in a pre-pubertal population free of other influences that may affect hs-CRP levels. We determined hs-CRP levels in 571 six- to eight-year-old children using an hs-CRP ELISA kit. Information on food and nutrient intake was obtained through a food-frequency questionnaire. Overall dietary quality was assessed using the Healthy Eating Index (HEI). We found that girls in the highest tertile of hs-CRP levels had a higher intake of saturated fatty acid, and lower intakes of fiber and vitamin E and a lower HEI score when compared to those in tertiles 1 and 2. We also observed a significant decrease in fruit and vegetable intakes by hs-CRP tertile. Factor analysis showed that a dietary pattern that was loaded most strongly with vegetable, fruit, fiber and vitamin A and E intakes correlated negatively (-0.132, p hs-CRP. No such association was found in boys. In conclusion, our data show that girls with a poorer quality diet show higher hs-CRP levels already at a pre-pubertal age.

  3. HS-4, a highly potent inhibitor of cell proliferation of human cancer cell

    Institute of Scientific and Technical Information of China (English)

    Gui-Lan Xing; Shu-Hong Tian; Xue-Li Xie; Jian Fu

    2015-01-01

    Objective:To investigate the antitumor activity of the compound HS-4 and the action mechanism.Methods:MTT method was used to testin vitroantitumor activity of the compound HS-4. Orthotopic xenotransplantation tumor model of liver cancer was established in nude mice, and,in vivoantitumor activity of compound HS-4 was tested with a small animal in-vivo imaging system. Sequencing of small RNA library and RNA library was performed in HS-4 treated tumor cell group and control group to investigate the anti-cancer mechanism of HS-4 at level of functional genomics, using high-throughput sequencing technology. Results:HS-4 was found to have relatively highin-vitro antitumor activity against liver cancer cells, gastric cancer cells, renal cancer cells, lung cancer cells, breast cancer cells and colon cancer cells. The IC50 values against SMMC-7721 and Bel-7402 of liver cancer cells were 0.14 and 0.13 nmol/L respectively, while the IC50 values against MGC-803 and SGC-7901 of gastric cancer cells were 0.19 and 0.21 nmol/L, respectively. It was demonstrated that HS- 4 possessed a better therapeutic effect in liver cancer.Conclusions: A new reliable orthotopic xenotransplantation tumor model of liver cancer in nude mice is established. The new compounds HS-4 was found to possess relatively highin vivo andin vitroantitumor activity against liver cancer cells.

  4. Hitachi的经济型投影机产品CP-HS900

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    CP-HS900是原Hitachi经济型产品CP-HS800的升级机型,采用3片0.55英寸液晶板和160W UHB灯泡。CP-HS900除配有CP-HS800的所有接口外还设计了RS-232C控制接口和USB鼠标控制接口,机器重量3.0kg。CP-HS900具有28dB降噪模式,演示过程中,听众不受噪音打扰。另

  5. Impact of different feedstocks derived biochar amendment with cadmium low uptake affinity cultivar of pak choi (Brassica rapa ssb. chinensis L.) on phytoavoidation of Cd to reduce potential dietary toxicity.

    Science.gov (United States)

    Yasmin Khan, Kiran; Ali, Barkat; Cui, Xiaoqiang; Feng, Ying; Yang, Xiaoe; Joseph Stoffella, Peter

    2017-07-01

    Biochar has become eco-friendly amendment used for phytoavoidation with low cadmium (Cd) accumulating cultivars of crops to ensure food safety in Cd contaminated soils. In this study, biochar with different waste feedstock material were evaluated for their effectiveness on essential trace metals mobility, Cd bioavailability and its accumulation in two contrasting Cd accumulating cultivars of pak choi (Brassica rapa ssp. chinensis L.) grown in Cd contaminated Mollisol soil. A greenhouse experiment was conducted with plants grown in Cd contaminated soil that had been amended with biochar derived from barley straw, tomato green waste, chicken manure, duck manure and swine manure at application rate of 0%, 2.5% and 5.0% (w/w). The results showed that soil pH was significantly increased by all treatments. Biochar increased plant dry biomass, micronutrients bioavailability with significant differences in the Cd sorption capacity, with the effectiveness higher with increasing biochar application rate. However, tomato green waste (TGW) and chicken manure (CM) derived biochar were more effective than the other biochar in reducing Cd mobilization in soil by 35-54% and 26-43% and reduced its accumulation in shoots of pak choi cultivars by 34-76% and 33-72% in low Cd accumulator cultivar and 64-85% and 55-80% in high Cd accumulator cultivar than the control. Overall, results indicate that TGW and CM biochar can efficiently immobilize Cd, thereby reducing bioavailability in Cd contaminated Mollisol soil to ensure food safety. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. 22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

  7. The poetry of Dunn Under the perspective of Carl Jung prototype Criticism%荣格原型批评视阙下的邓恩诗歌

    Institute of Scientific and Technical Information of China (English)

    徐亚飞

    2013-01-01

    本文试图通过荣格的原型批评理论分析邓恩诗歌,具体分析了邓恩诗歌中的原型意象,以说明邓恩在诗歌创作过程中受到原型的支配,既是“艺术的工具”,同时也是“更高意义上的‘人’”。%This paper is to analyze John Donne`s poems on the basis of C.G. Jung`s archetypal criticism and focuses on archetypal imagery in Donne`s poems so as to show that Donne was influenced by archetypes when writing poetry. And John Donne was a“vehicle of arts”as well as a“man”in higher sense when engaged in writing poems.

  8. Retinol-binding protein-4 and hs-CRP levels in patients with migraine.

    Science.gov (United States)

    Tanik, Nermin; Celikbilek, Asuman; Metin, Aslı; Gocmen, Ayse Yesim; Inan, Levent Ertugrul

    2015-10-01

    Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II. The serum RBP4 level was measured using a commercial ELISA kit and hs-CRP was measured using an enzyme immunoassay test kit. The serum RBP4 level was significantly lower in the migraine patients than in the controls (P hs-CRP level was significantly higher in the migraine patients (P hs-CRP levels did not differ between the migraine patients with and without aura (P > 0.05). Migraine headache severity, frequency and duration were not correlated with serum RBP or hs-CRP levels (P > 0.05). The observed high hs-CRP level and low RBP4 level in migraine patients suggest that vitamin A might play a major role in the pathogenesis of migraine. It is known that inflammation is a key factor in many diseases. Additional research might result in a better understanding of the anti-inflammatory effects of vitamin A.

  9. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011.

    Directory of Open Access Journals (Sweden)

    Solange Missagia Matos

    2013-03-01

    Full Text Available DISSERTAÇÃO DE MESTRADOMATTOS, Solange Missagia. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011. 115 folhas. Dissertação (Mestrado – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

  10. Do Círculo de Eranos à construção do simbólico, em Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Amauri Carlos Ferreira

    2015-08-01

    Full Text Available O artigo discute a origem e a extensão do Círculo de Eranos e sua importância na compreensão do simbólico, estabelecendo a compreensão da construção do simbólico como tentativa de união entre Oriente e Ocidente em C. G. Jung.

  11. Analytical psychology and Daoist inner alchemy: a response to C.G. Jung's 'Commentary on The Secret of the Golden Flower'.

    Science.gov (United States)

    Zhu, Caifang Jeremy

    2009-09-01

    This paper provides a historical, religious-philosophical context for the study of the Daoist text known as The Secret of the Golden Flower. An updated study is conducted into the controversy over the source of the text including the editions translated by Richard Wilhelm and Thomas Cleary. The main teachings of the text and the basics of two major denominations of Daoism are introduced to ground later critiques of Jung's commentary. The psychodynamics of analytical psychology, especially those concerned with integration of unconscious contents and the realization of the self (individuation) are compared with the psycho-spiritual dynamics of integration in Eastern spirituality based on the Golden Flower text. The paper concludes that it was amiss for Jung to have equated the Western 'unconscious' with states of higher consciousness in Eastern meditation practices, although his claim that Eastern higher consciousness is characterized by a nebulous state of non-intentionality does raise questions about the appropriateness of calling Eastern meditative states 'consciousness'. A new concept is required to characterize the special qualities of this psychic state shared generally by Eastern spiritual traditions and a more meaningful comparison may be found in Jung's concept of the self.

  12. Carl gustav jung, quantum physics and the spiritual mind: a mystical vision of the twenty-first century.

    Science.gov (United States)

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-12-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung's psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn't consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind.

  13. Changing the conversation--the occupational health nurse's role in integrated HS3.

    Science.gov (United States)

    Weiss, Marjorie D

    2009-07-01

    Occupational health nurses have the skills and knowledge to provide a holistic perspective in advancing their company's triple bottom line, healthy people, healthy planet, and healthy profits. The HS3 model provides a road map for integrating health, safety, sustainability, and stewardship, all of which directly impact every company's triple bottom line. Occupational health nurses can use the HS3 model to promote healthy lifestyles, reduce risk and injuries, protect the natural environment, and improve resource alignment. Occupational health nurses have a unique opportunity to demonstrate the value they bring to their employers using synergistic HS3 planning that cost-effectively links work injury management, health promotion, environmental protection, safety training and surveillance, and regulatory compliance. Implementing the HS3 model requires occupational health nurses to be innovators who can change the conversation.

  14. Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP

    DEFF Research Database (Denmark)

    Mogelvang, Rasmus; Haahr-Pedersen, Sune; Bjerre, Mette;

    2013-01-01

    To evaluate the association of plasma osteoprotegerin (OPG) to hospitalisation for ischaemic heart disease (IHD), ischaemic stroke and all-cause mortality, and the effect of combining plasma OPG and high-sensitivity C-reactive protein (hsCRP).......To evaluate the association of plasma osteoprotegerin (OPG) to hospitalisation for ischaemic heart disease (IHD), ischaemic stroke and all-cause mortality, and the effect of combining plasma OPG and high-sensitivity C-reactive protein (hsCRP)....

  15. HS2ST MEDIATED KIDNEY MESENCHYME INDUCTION REGULATES EARLY URETERIC BUD BRANCHING

    OpenAIRE

    Mita M. Shah; Sakurai, Hiroyuki; Sweeney, Derina E.; Gallegos, Thomas F.; Bush, Kevin T.; Esko, Jeffrey D.; Nigam, Sanjay K

    2010-01-01

    Heparan sulfate proteoglycans (HSPGs) are central modulators of developmental processes likely through their interaction with growth factors, such as GDNF, members of the FGF and TGFβ superfamilies, EGF receptor ligands and HGF. Absence of the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis. Using a novel combination of in vivo and in vitro approaches, we have reanalyzed the defect in morphogenesis of the Hs2st−/− kidney. We observed that, while the ...

  16. Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni.

    Science.gov (United States)

    Suttiprapa, Sutas; Rinaldi, Gabriel; Brindley, Paul J

    2012-06-01

    Vesicular stomatitis virus glycoprotein (VSVG) pseudotyped murine leukemia virus (MLV) virions can transduce schistosomes, leading to chromosomal integration of reporter transgenes. To develop VSVG-MLV for functional genomics in schistosomes, the influence of the chicken β-globin cHS4 element, a prototypic chromatin insulator, on transgene expression was examined. Plasmid pLNHX encoding the MLV 5'- and 3'-Long Terminal Repeats flanking the neomycin phosphotransferase gene (neo) was modified to include, within the U3 region of the 3'-LTR, active components of cHS4 insulator, the 250 bp core fused to the 400 bp 3'-region. Cultured larvae of Schistosoma mansoni were transduced with virions from producer cells transfected with control or cHS4-bearing plasmids. Schistosomules transduced with cHS4 virions expressed 2-20 times higher levels of neo than controls, while carrying comparable numbers of integrated proviral transgenes. The findings not only demonstrated that cHS4 was active in schistosomes but also they represent the first report of activity of cHS4 in any Lophotrochozoan species, which has significant implications for evolutionary conservation of heterochromatin regulation. The findings advance prospects for transgenesis in functional genomics of the schistosome genome to discover intervention targets because they provide the means to enhance and extend transgene activity including for vector based RNA interference.

  17. Evaluation of Usefulness of hs-CRP and Ferritin Assays in Patients with Nasal Polyps

    Directory of Open Access Journals (Sweden)

    Robert Partyka

    2014-01-01

    Full Text Available Background. Chronic nature of the nasal polyps, tendency to recurrence, and lack of satisfying treatment need the diagnostic’s parameters which show early inflammatory state as ferritin and hs-CRP. The Aim of Study. Assessment of hs-CRP and ferritin blood levels in nasal polyps patients in evaluation of treatment efficacy. Methods. All 38 patients were divided into 2 groups. Group I included 19 patients with anti-inflammatory therapy 2 weeks after surgery. Group II included 19 patients without anti-inflammatory therapy 2 weeks after surgery. The levels of hs-CRP and ferritin have been assessed before and 2 and 6 weeks after surgical treatment. Results. Research showed statistically significant difference of ferritin’s concentration between examined groups 6 weeks after surgery (P<0.05 and statistically significant difference of hs-CRP concentration 2 and 6 weeks after surgery (P<0.05. Conclusion. (1 The analysis of serum ferritin and hs-CRP concentrations can be useful in early postoperative detection of inflammatory state in patients with nasal polyps and for the effectiveness of therapy. (2 Lack of correlation between mean ferritin and hs-CRP serum levels, at each diagnostic and monitoring stage, shows that they are independent and cannot be determined interchangeably.

  18. Prevalence of Hidradenitis Suppurativa (HS): A Population-Based Study in Olmsted County, Minnesota

    Science.gov (United States)

    Shahi, Varun; Alikhan, Ali; Vazquez, Benjamin G.; Weaver, Amy L.; Davis, Mark D.

    2014-01-01

    BACKGROUND/AIMS Hidradenitis suppurativa (HS) is a follicular occlusion disorder occurring in apocrine-rich regions of the skin. Estimates of the prevalence of this disorder have not been population-based. We sought to provide population-based information on the prevalence of HS in Olmsted County, Minnesota as of 1/1/2009. METHODS Rochester Epidemiology Project, a unique infrastructure that combines and makes accessible all medical records in Olmsted County since the 1960s, was used to collect population-based data on the prevalence of HS. RESULTS We identified 178 confirmed cases of HS that included 135 females and 43 males, and estimated the total sex- and age-adjusted prevalence in Olmsted County to be 127.8 per 100,000 or 0.13%. The total prevalence was significantly higher among women than men. CONCLUSION This study represents the first population-based investigation on the prevalence of HS. In this population-based cohort, HS was less prevalent than previous reports have suggested. PMID:25228133

  19. A CORRELATION STUDY BETWEEN CONVENTIONAL LIPID PARAMETERS AND HS - CRP IN CORONARY HEART DISEASE

    Directory of Open Access Journals (Sweden)

    Rangaswamy

    2015-05-01

    Full Text Available BACKGROUND: Coronary heart disease (CHD is the most common form of heart disease. Changes in lifestyle, decreased physical activity, dietary modifications etc., in indian population is considered to be the major risk factor. By 2020 it is estimated that it will be th e major cause of death in the world. High sensitivity CRP (hs - CRP test measures very small amounts of CRP in the blood and is helpful even in healthy individuals to assess their potential risk for heart ailments. The hs - CRP levels are directly proportiona l to extent source of CHD which indicates that the hs - CRP has positive correlation with the disease burden. Hence the present study was undertaken. MATERIAL AND METHODS: The study was done by taking two groups controls and cases between the ages 25 - 60 year s. Fasting blood samples were collected and analysed for estimation of triglycerides, cholesterol, LDL - cholesterol, HDL - cholesterol and hs - crp levels. RESULT: Serum levels of cholesterol, TG, LDL - C, and hs - CRP (p - value 0.0001 were significantly increased and HDL - C (p - value 0.0002 was significantly decreased in cases as compared to healthy controls. CONCLUSION: It is seen that hs - CRP level is significantly elevated in cases (MI patients than the normal controls. So the present study shows a significant a nd positive correlation with conventional lipid profile parameters.

  20. An existential criterion of normal and abnormal personality in the works of Carl Jung and Carl Rogers

    Directory of Open Access Journals (Sweden)

    Kapustin, Sergey A.

    2016-06-01

    Full Text Available This article is the third in a series of four articles scheduled for publication in this journal. In the first article (Kapustin, 2015a I proposed a description of a new so-called existential criterion of normal and abnormal personality that is implicitly present in the works of Erich Fromm. According to this criterion, normal and abnormal personalities are determined, first, by special features of the content of their position regarding existential dichotomies that are natural to human beings and, second, by particular aspects of the formation of this position. Such dichotomies, entitatively existent in all human life, are inherent, two-alternative contradictions. The position of a normal personality in its content orients a person toward a contradictious predetermination of life in the form of existential dichotomies and necessitates a search for compromise in resolving these dichotomies. This position is created on a rational basis with the person’s active participation. The position of an abnormal personality in its content subjectively denies a contradictious predetermination of life in the form of existential dichotomies and orients a person toward a consistent, noncompetitive, and, as a consequence, onesided way of life that doesn’t include self-determination. This position is imposed by other people on an irrational basis. Abnormality of personality interpreted like that is one of the most important factors influencing the development of various kinds of psychological problems and mental disorders — primarily, neurosis. In the second article (Kapustin, 2015b I showed that this criterion is also implicitly present in the personality theories of Sigmund Freud and Alfred Adler, although in more specific cases. In the current work I prove that this criterion is also present in the personality theories of Carl Jung and Carl Rogers, where it is implicitly stated in a more specific way. In the final article I will show that this criterion

  1. Retrovirus silencer blocking by the cHS4 insulator is CTCF independent

    Science.gov (United States)

    Yao, Shuyuan; Osborne, Cameron S.; Bharadwaj, Rikki R.; Pasceri, Peter; Sukonnik, Tanya; Pannell, Dylan; Recillas-Targa, Félix; West, Adam G.; Ellis, James

    2003-01-01

    Silencing of retrovirus vectors poses a significant obstacle to genetic manipulation of stem cells and their use in gene therapy. We describe a mammalian silencer blocking assay using insulator elements positioned between retrovirus silencer elements and an LCRβ-globin reporter transgene. In transgenic mice, we show that retrovirus silencers are blocked by the cHS4 insulator. Silencer blocking is independent of the CTCF binding site and is most effective when flanking the internal reporter transgene. These data distinguish silencer blocking activity by cHS4 from its enhancer blocking activity. Retrovirus vectors can be created at high titer with one but not two internal dimer cHS4 cores. cHS4 in the LTRs has no effect on expression in transduced F9 cells, suggesting that position effect blocking is not sufficient to escape silencing. The Drosophila insulators gypsy and Scs fail to block silencing in transgenic mice, but gypsy stimulates vector expression 2-fold when located in the LTRs of an infectious retrovirus. The silencer blocking assay complements existing insulator assays in mammalian cells, provides new insight into mechanisms of insulation and is a valuable tool to identify additional silencer blocking insulators that cooperate with cHS4 to improve stem cell retrovirus vector design. PMID:12954767

  2. Changes of levels of hs-CRP, Hsp70, and MPO in patients with preeclampsia

    Institute of Scientific and Technical Information of China (English)

    Xia Liu

    2016-01-01

    Objective:To observe the changes of the levels of hs-CRP, Hsp70, and MPO in patients with preeclampsia (PE) and their clinical significance. Methods:A total of 60 pregnant women with mild and severe PE who were admitted in our hospital from January, 2013 to March, 2014 were included in the study and divided into the mild group and the severe group with 30 cases in each group. The levels of serum hs-CRP, Hsp70, and MPO were detected, and their relations with PE were analyzed. The lipid metabolism related indicators were meanwhile detected. A total of 30 healthy later pregnant women at the same stage were served as the control group for comparative analysis. Results:The levels of serum hs-CRP, Hsp70, and MPO in the mild and severe PE group were significantly higher than those in the control group (P0.05). Conclusions: The abnormal lipid metabolism in different degrees exists in the pregnant women with PE, and hs-CRP, Hsp70, and MPO are together involved in the pathogenesis of PE. Detection of the levels of hs-CRP, Hsp70, and MPO in the pregnant women with PE can accurately reflect the condition of PE.

  3. Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery.

    Science.gov (United States)

    Cho, Hyun-Jong; Park, Ju-Hwan; Kim, Dae-Duk; Yoon, In-Soo

    2016-02-01

    Docetaxel (DCT) is one of anti-mitotic chemotherapeutic agents and has been used for the treatment of gastric cancer as well as head and neck cancer, breast cancer and prostate cancer. Poly(lactic- co-glycolic) acid (PLGA) is one of representative biocompatible and biodegradable polymers, and polyoxyl 15 hydroxystearate (Solutol HS15) is a nonionic solubilizer and emulsifying agent. In this investigation, PLGA/Solutol HS15-based nanoparticles (NPs) for DCT delivery were fabricated by a modified emulsification-solvent evaporation method. PLGA/Solutol HS15/DCT NPs with about 169 nm of mean diameter, narrow size distribution, negative zeta potential, and spherical morphology were prepared. The results of solid-state studies revealed the successful dispersion of DCT in PLGA matrix and its amorphization during the preparation process of NPs. According to the result of in vitro release test, emulsifying property of Solutol HS15 seemed to contribute to the enhanced drug release from NPs at physiological pH. All these findings imply that developed PLGA/Solutol HS15-based NP can be a promising local anticancer drug delivery system for cancer therapy.

  4. Assessment of the governance system for the management of the East Sea-Jung dumping site, Korea through analysis of heavy metal concentrations in bottom sediments

    Science.gov (United States)

    Song, Ki-Hoon; Choi, Ki-Young; Kim, Chang-Joon; Kim, Young-Il; Chung, Chang-Soo

    2015-12-01

    As with many countries, the Korea government has made a variety of efforts to meet the precautionary principle under the London Convention and Protocol acceded in 1994 and 2009. However, new strategies for the suitable marine dumping of waste materials have since been developed. In this study, the distribution and contamination of heavy metals including Al, Fe, Mn, Li, Co, Cr, Ni, Cu, Zn, As, Cd, Pb and Hg in bottom sediments were analyzed and compared to various criteria in order to evaluate the effectiveness of the management of the East Sea-Jung (ES-Jung) dumping site by the Korea government. The results indicate that the average metal concentrations were significantly lower than Effects Range Low (ERL) values, and generally similar to or lower than the Threshold Effect Levels (TEL) from the Sediment Quality Guidelinces (SQGs). According to analyses of various metal contamination indexes (Enrichment Factor: EF, Pollution Load Index: PLI and the Index of Geoaccumulation: Igeo), most areas were found to be uncontaminated by heavy metals with the exception of several moderately contaminated stations (ESJ 33, 54, 64 and ESJR 20). Heavy metal concentrations in areas grouped as G1, G2, DMDA, N-Ref and S-Ref which showed similar characteristics between 2007-2013 and 2014, were compared. Unexpectedly, most concentrations in the northern reference area (N-Ref) were much higher than those in the actual dumping areas (G1 and G2), may be due to the influences from nearby cities to the west of the ES-Jung site, rather than from the dumping site itself. Additionally, heavy metal concentrations in the dredged material dumping area (DMDA) were found to be low although they have slightly increased over time and those in the southern reference area (S-Ref) were found to have gradually decreased with year. The concentrations of most metals in the East Sea-Jung dumping site were similar to or less than those in the Earth's crust and approximately the same as those in continental

  5. Stabilizing Superacid Anions: The New [H(S4 O13 )2 ](3-) Anion in the Crystal Structure of Li3 [H(S4 O13 )2 ].

    Science.gov (United States)

    Schindler, Lisa Verena; Becker, Anna; Wickleder, Mathias Siegfried

    2016-12-05

    The unique hydrogenium-bis-tetrasulfate anion [H(S4 O13 )2 ](3-) in the crystal structure of Li3 [H(S4 O13 )2 ] (monoclinic, P21 /n (No. 14), Z=2, a=552.46(4) pm, b=939.70(6) pm, c=1876.6(1) pm, β=97.492(3)°, V=965.9(1)⋅10(6)  pm(3) ) is the longest protonated polysulfate chain ever observed. Very strong symmetrical hydrogen bonds are a bold feature of the crystal structure. The protonation of a very weak base such as [S4 O13 ](2-) and accordingly the stabilization of the first base of the superacid H2 S4 O13 is a significant success towards the still elusive polysulfuric acids.

  6. DEVELOPMENT OF THE HS99 AIR TRANSPORT TYPE A FISSILE PACKAGE

    Energy Technology Data Exchange (ETDEWEB)

    Blanton, P.; Eberl, K.

    2012-07-10

    An air-transport Type A Fissile radioactive shipping package for the transport of special form uranium sources has been developed by the Savannah River National Laboratory (SRNL) for the Department of Homeland Security. The Package model number is HS99 for Homeland Security Model 99. This paper presents the major design features of the HS99 and highlights engineered materials necessary for meeting the design requirements for this light-weight Type AF packaging. A discussion is provided demonstrating how the HS99 complies with the regulatory safety requirements of the Nuclear Regulatory Commission. The paper summarizes the results of structural testing to specified in 10 CFR 71 for Normal Conditions of Transport and Hypothetical Accident Conditions events. Planned and proposed future missions for this packaging are also addressed.

  7. ICARE-HS: atmospheric correction of airborne hyperspectral urban images using 3D information

    Science.gov (United States)

    Ceamanos, Xavier; Briottet, Xavier; Roussel, Guillaume; Gilardy, Hugo

    2016-10-01

    The algorithm ICARE-HS (Inversion Code for urban Areas Reflectance Extraction using HyperSpectral imagery) is presented in this paper. ICARE-HS processes airborne hyperspectral images for atmospheric compensation taking into account the strong relief of urban areas. A digital surface model is used to provide the 3D information, which is key to simulating relief-related effects such as shadow casting, multiple reflections between objects and variable illumination depending on local solid angle of view of the sky. Some of these effects are modeled using ray tracing techniques. ICARE-HS is applied to airborne hyperspectral data of the city center of Toulouse, which are also processed by a standard atmospheric correction method for comparison.

  8. Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.

    Science.gov (United States)

    Vincent-Fabert, Christelle; Truffinet, Véronique; Fiancette, Remi; Cogné, Nadine; Cogné, Michel; Denizot, Yves

    2009-06-01

    Several studies have reported that regulatory elements located 3' of the IgH locus (namely hs3a, hs1,2, hs3b, and hs4) might play a role during class switch recombination (CSR) and Ig synthesis. While individual deletion of hs3a or hs1,2 had no effect, pairwise deletion of hs3b (an inverted copy of hs3a) and hs4 markedly affected CSR and Ig expression. Among these two elements, hs4 was tentatively presented with the master role due to its unique status within the 3' regulatory region: distal position outside repeated regions, early activation in pre-B cells, strong activity throughout B cell ontogeny. To clarify its role, we generated mice with a clean deletion of the hs4 after replacement with a floxed neo(R) cassette. Surprisingly, and as for previous deletion of hs3a or hs1,2, deletion of hs4 did not affect either in vivo CSR or the secretion level of any Ig isotype. In vitro CSR and Ig secretion in response to LPS and cytokines was not affected either. The only noticeable effects of the hs4 deletion were a decrease in the number of B splenocytes and a decreased membrane IgM expression. In conclusion, while dispensable for CSR and Ig transcription in plasma cells, hs4 mostly appears to contribute to Ig transcription in resting B lymphocytes.

  9. Waist Circumference was Positively Correlated with Chemerin, Retinol-Binding Protein 4 and hsCRP

    Directory of Open Access Journals (Sweden)

    Lucia Herminawati

    2012-04-01

    Full Text Available BACKGROUND: Central obesity is associated with various chronic metabolic disorders characterized by abnormal cytokine production, increased acute phase reactants, and activation of inflammatory signaling pathways. This study was aimed to investigate the association of waist circumference, chemerin, and retinol binding protein (RBP-4 with inflammation in men with central obesity. METHODS: The research was conducted with a crosssectional design involving 68 centrally obese male subjects aged 30 to 60 years old, with waist circumference (WC >90 cm. All subjects fulfilled the inclusion and exclusion criteria. Anthropometric parameters, fasting glucose, creatinine, SGOT, SGPT, and hsCRP were measured. Serum concentrations of chemerin and RBP4 were measured by ELISA. RESULTS: The trend lines showed that chemerin, RBP4 and hsCRP increased with WC. Pearson correlation test showed a positively significant correlation between WC and hsCRP (r=0.242, p<0.05; and also between chemerin and hsCRP (r=0.244, p<0.05 and RBP4 (r=0.321, p<0.01. Subjects were stratified into four groups based on their chemerin and RBP4 levels (high chemerin/high RBP4, high chemerin/low RBP4, low chemerin/high RBP4, or low chemerin/low RBP4. Subjects who were in the high chemerin/low RBP4 group were more likely to have high level of inflammation (47.6%, but subjects with high chemerin/high RBP4 showed low level of inflammation (42.9% as compared with the other three groups. CONCLUSIONS: We concluded that increased WC was correlated with elevated levels of chemerin, RBP4 and hsCRP. High chemerin was correlated with increased level of RBP4 as well as with high level of inflammation. KEYWORDS: waist circumference, chemerin, RBP4, hsCRP, inflammation.

  10. Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.

    Science.gov (United States)

    Yan, Yi; Pieretti, Joyce; Ju, Zhongliang; Wei, Shiniu; Christin, John R; Bah, Fatmata; Birshtein, Barbara K; Eckhardt, Laurel A

    2011-08-01

    Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The processes involved must be regulated, however, to avoid unintended damage to chromosomes. The 3' regulatory region of the Igh locus plays a major role in regulating class-switch recombination (CSR), the process by which antibody effector functions are modified during an immune response. Loss of all known enhancer-like elements in this region dramatically impairs CSR, but individual element deletions have no effect on this process. In the present study, we explored the hypothesis that an underlying functional redundancy in the homologous elements hs3a and hs3b was masking the importance of either element to CSR. Several transgenic mouse lines were generated, each carrying a bacterial artificial chromosome transgene that mimicked Igh locus structure but in which hs3a was missing and hs3b was flanked by loxP sites. Matings to Cyclization Recombination Enzyme-expressing mice established "pairs" of lines that differed only in the presence or absence of hs3b. Remarkably, CSR remained robust in the absence of both hs3a and hs3b, suggesting that the remaining two elements of the 3' regulatory region, hs1.2 and hs4, although individually dispensable for CSR, are, together, sufficient to support CSR.

  11. Effect of the administration time of HS6101 on hematopoietic recovery in ICR mice injured by cyclophosphamide

    Directory of Open Access Journals (Sweden)

    Shuang XING

    2015-06-01

    Full Text Available Objective To explore the effect of the administration time of HS6101 on hematopoietic recovery in ICR mice injured by cyclophosphamide (CTX. Methods One hundred and three male ICR mice were divided into 4 groups: CTX control, HS6101 prevention, HS6101 treatment, and HS6101 prevention+treatment groups. CTX was intraperitoneally injected into the ICR mice at a dose of 100mg/(kg.d for three consecutive days to establish a chemotherapeutics-injured model. HS6101 at a dose of 27μg/mouse in 0.2ml was subcutaneously injected into the mice 1h before the first administration of CTX in HS6101-prevention group, 1h after the last administration of CTX in HS6101 treatment group, and both at 1h before the first administration and 1h after the last administration of CTX in HS6101 prevention + treatment group. Physiological saline was subcutaneously injected into the mice in CTX control group (0.2ml/mouse. 10μl peripheral blood was collected from the caudal vein for WBC, neutrophil lymphocyte, RBC and platelet counts on day -1, 3, 5, 7, 9, 11, 13, 15, 17 with the MEK-7222K cell analyzer, and the cell count was compared between HS6101 treatment mice and CTX control mice. Another 30 male ICR mice were used for bone marrow colony forming unit (CFU assay and bone marrow histopathological examination, and they were assigned into normal control, CTX control, HS6101 prevention, HS6101treatment and HS6101 prevention + treatment groups (each n=6. On the day 4 and day 9 after CTX injection, mice were sacrificed and bone marrow cells were collected from the left femur for mononuclear cell (MNC isolation. 1×104 MNCs were planted in 1.0ml mouse CFU culture medium M3434 and cultured in incubator with the temperature of 37℃, and 5% CO2 for 7 days. After that, granulocyte macrophage-colony-forming unit (GM-CFU, megakaryocyte colony forming unit (MK-CFU, mixture-colony-forming unit (Mix-CFU, burst-forming unit-erythroid (BFU-E and colony-forming unit-erythroid (CFU

  12. Packing density of HS(CH2)(n)COOH self-assembled monolayers.

    Science.gov (United States)

    Snow, A W; Jernigan, G G; Ancona, M G

    2011-12-01

    Self-assembled monolayers (SAMs) of HS(CH(2))(n)COOH, n = 5, 10, 15 deposited from ethanol solution onto gold are prepared by five approaches, and their packing densities are evaluated by X-ray photoelectron spectroscopy (XPS) measurements. The five approaches are: (1) direct deposition; (2) acetic-acid-assisted deposition; (3) butyl-amine-assisted deposition; (4) displacement of a preformed HS(CH(2))(n)CH(3) (n = 5, 10, 15) SAMs; and (5) co-deposition with HS(CH(2))(n)CH(3) (n = 5, 10, 15). Packing density metrics are calculated from measurements of SAM and substrate photoemission intensities and their attenuations by two methods. In one case the attenuated photoemissions are expressed as a ratio relative to comparable measurements on an experimental HS(CH(2))(n)CH(3) model system. In the other case a new method is introduced where a calculated attenuation based on theoretical random coil and extended chain models is used as the reference to determine a packing density fraction. Packing densities are also correlated with the S2p(Au-bonded):Au4f peak area ratios and with shifts in the C1s binding energies. SAMs prepared by the direct deposition are a partial multilayer where a second molecular layer is physisorbed onto the SAM and not removable by solvent washing. The addition of acetic acid to the deposition solution disrupts dimer associations of HS(CH(2))(n)COOH in solution and at the surface of the monolayer and yields the most ordered monolayer with the highest density of -COOH groups. The addition of butyl amine results in a labile ammonium carbonate ion pair formation but results in a lower packing density in the SAM. The displacement of the preformed HS(CH(2))(n)CH(3) SAM and the co-deposition of HS(CH(2))(n)CH(3) with HS(CH(2))(n)COOH result in SAMs with little incorporation of the -COOH component.

  13. PHOTOMETRIC ANALYSIS OF HS Aqr, EG Cep, VW LMi, AND DU Boo

    Energy Technology Data Exchange (ETDEWEB)

    Djurasevic, G.; Latkovic, O. [Astronomical Observatory, Volgina 7, 11000 Belgrade (Serbia); Bastuerk, Oe.; Y Latin-Small-Letter-Dotless-I lmaz, M. [Astronomy and Space Sciences Research and Application Center, Ankara University, TR-06837 Ahlatl Latin-Small-Letter-Dotless-I bel, Ankara (Turkey); Cal Latin-Small-Letter-Dotless-I skan, S.; Senavc Latin-Small-Letter-Dotless-I , H. V.; K Latin-Small-Letter-Dotless-I l Latin-Small-Letter-Dotless-I coglu, T.; Ekmekci, F. [Department of Astronomy and Space Sciences, Faculty of Science, Ankara University, TR-06100 Tandogan, Ankara (Turkey); Tanr Latin-Small-Letter-Dotless-I verdi, T., E-mail: olivia@aob.rs [Department of Physics, Faculty of Arts and Sciences, Nigde University, 51240 Nigde (Turkey)

    2013-03-15

    We analyze new multicolor light curves for four close late-type binaries: HS Aqr, EG Cep, VW LMi, and DU Boo, in order to determine the orbital and physical parameters of the systems and estimate the distances. The analysis is done using the modeling code of G. Djurasevic, and is based on up-to-date measurements of spectroscopic elements. All four systems have complex, asymmetric light curves that we model by including bright or dark spots on one or both components. Our findings indicate that HS Aqr and EG Cep are in semi-detached, while VW LMi and DU Boo are in overcontact configurations.

  14. 2376例患儿血液hs-CRP和白细胞计数结果分析

    Institute of Scientific and Technical Information of China (English)

    梁安玉

    2014-01-01

    目的:通过分析同一血液标本中超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)检测结果及出现此结果的原因,从而为儿科临床医生诊治疾病提供有力的依据。方法:选取2376例患儿同一血液标本同时测定hs-CRP、WBC,对测定结果进行比较分析。结果:hs-CRP升高占63.8%,WBC升高占39.4%,hs-CRP和WBC均升高占29.8%,hs-CRP和WBC均正常占22.1%,hs-CRP升高而WBC正常占26.1%,hs-CRP升高而WBC降低占7.9%;hs-CRP正常而WBC降低占4.5%;hs-CRP正常而WBC升高占9.6%。结论:hs-CRP和白细胞均可作为感染的判断指标, hs-CRP更优于白细胞,hs-CRP和白细胞可出现各种不同的结果,两者结合判断更有利于患儿疾病的诊治。

  15. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching.

    Science.gov (United States)

    Shah, Mita M; Sakurai, Hiroyuki; Sweeney, Derina E; Gallegos, Thomas F; Bush, Kevin T; Esko, Jeffrey D; Nigam, Sanjay K

    2010-03-15

    Heparan sulfate proteoglycans (HSPGs) are central modulators of developmental processes likely through their interaction with growth factors, such as GDNF, members of the FGF and TGFbeta superfamilies, EGF receptor ligands and HGF. Absence of the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis. Using a novel combination of in vivo and in vitro approaches, we have reanalyzed the defect in morphogenesis of the Hs2st(-)(/)(-) kidney. Utilizing assays that separately model distinct stages of kidney branching morphogenesis, we found that the Hs2st(-/-) UB is able to undergo branching and induce mesenchymal-to-epithelial transformation when recombined with control MM, and the isolated Hs2st null UB is able to undergo branching morphogenesis in the presence of exogenous soluble pro-branching growth factors when embedded in an extracellular matrix, indicating that the UB is intrinsically competent. This is in contrast to the prevailing view that the defect underlying the renal agenesis phenotype is due to a primary role for 2-O sulfated HS in UB branching. Unexpectedly, the mutant MM was also fully capable of being induced in recombination experiments with wild-type tissue. Thus, both the mutant UB and mutant MM tissue appear competent in and of themselves, but the combination of mutant tissues fails in vivo and, as we show, in organ culture. We hypothesized a 2OS-dependent defect in the mutual inductive process, which could be on either the UB or MM side, since both progenitor tissues express Hs2st. In light of these observations, we specifically examined the role of the HS 2-O sulfation modification on the morphogenetic capacity of the UB and MM individually. We demonstrate that early UB branching morphogenesis is not primarily modulated by factors that depend on the HS 2-O sulfate modification; however, factors that contribute to MM induction are markedly sensitive to the 2-O sulfation modification. These data suggest that key

  16. El libro como soporte de la experiencia visionaria en las profecías iluminadas de William Blake y el Libro Rojo de Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Daniela Picón Bruno

    2017-01-01

    Full Text Available En este artículo reflexionamos sobre dos obras pertenecientes al mundo moderno y contemporáneo en las que el manuscrito iluminado es utilizado como soporte de registro de la experiencia visionaria: los Libros Proféticos Iluminados de William Blake (1757-1827 y el Libro Rojo de Carl Gustav Jung (1875-1961. Estos autores consideraron el manuscrito iluminado como un formato más auténtico para la transmisión de sus visiones, ya que permitía superar la dimensión puramente estética del arte y convocar una síntesis entre la materia y el espíritu propio del pensamiento simbólico del neoplatonismo del siglo xii europeo. Desde esta perspectiva, indagamos en el carácter altamente espiritual que Blake y Jung confirieron a la creación artística y a la materialidad del libro como soporte de escritura y de lectura, estableciendo algunas correspondencias con las nuevas concepciones sobre el arte elaboradas en el contexto de las vanguardias europeas del siglo xx.

  17. L’innovation en autobiographie selon Jung : une exploration du média de la bande dessinée

    Directory of Open Access Journals (Sweden)

    Kevin Pat Fong

    2012-05-01

    Full Text Available Depuis le succès phénoménal de Maus d’Art Spiegelman, la bande dessinée a obtenu une certaine reconnaissance dans l’institution littéraire. Jung, scénariste et dessinateur belge d’origine coréenne, partage avec nous son récit autobiographique en noir et blanc intitulé Couleur de Peau : Miel – Tome 1 (1997. Son histoire débute par le récit de son enfance comme orphelin grandissant en Corée du sud, pour être ensuite adopté par une famille belge jusqu’à l’adolescence. Avec un mélange ingénieux d’humour, de sarcasme et de drame, Jung aborde des sujets sérieux et contemporains tels que la quête d’identité, le déracinement, l’abandon, l’intégration et un sujet peu exploré et méconnu du public : l’adoption des enfants coréens par les familles des pays développés.

  18. THE CAUCHY PROBLEM OF NONLINEAR SCHR(O)DINGER-BOUSSINESQ EQUATIONS IN Hs(Rd)

    Institute of Scientific and Technical Information of China (English)

    Han Yongqian

    2005-01-01

    In this paper, the local well posedness and global well posedness of solutions for the initial value problem (IVP) of nonlinear Schrodinger-Boussinesq equations is considered in Hs(Rd) by resorting Besov spaces, where real number s ≥ 0.

  19. Genomic sequence of Campylobacter jejuni subsp. jejuni HS:19 Penner serotype reference strain RM3420

    NARCIS (Netherlands)

    C.T. Parker (Craig); Huynh, S. (Steven); A.P. Heikema (Astrid)

    2017-01-01

    textabstractCampylobacter jejuni subsp. jejuni infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Penner serotype HS:19 is among several capsular types shown to be markers for GBS. This study describes the genome of C.

  20. Baseline distribution and correlation analysis of hsCRP in an insurance applicant population.

    Science.gov (United States)

    Krause, Kenneth J; Williams, David S; White, Nancy

    2008-01-01

    Many clinical studies have shown that baseline levels of high sensitivity C-reactive protein (hsCRP) in apparently healthy men and women are highly predictive of future risk of heart attack, stroke, sudden cardiac death, and the development of peripheral arterial disease. This paper presents an analysis of the baseline characteristics of our prospective study cohort. The intent of our prospective study is to determine whether hsCRP can be used to better classify risk for life insurance applicants already at risk for cardiovascular events, as well as those who are not. The possibility that low levels of hsCRP levels in otherwise healthy applicants might be associated with more favorable cardiovascular risk could allow this test to be used to more precisely stratify risk in the standard-or-better underwriting classifications. In this preliminary analysis, high sensitivity CRP appears to be weakly correlated with BMI, and perhaps triglyceride level in this cohort of insurance applicants. Somewhat surprisingly, in contrast to many published reports, hsCRP was not found to be correlated with other lipid measures (TC, HDL, LDL), dysmetabolic markers or smoking classification during the underwriting process. We plan to analyze mortality results as they evolve in the future.

  1. The Role of the Media in South African Construction Health and Safety (H&S

    Directory of Open Access Journals (Sweden)

    John Smallwood

    2012-11-01

    Full Text Available A large number of fatalities and injuries occur in the South African construction industry. Traditionally, the print media have dedicated editorial, published news, articles and letters, and have exposed abusive or non-conforming conditions and practices in terms of H&S. Literature also indicates that the print media can influence and has an impact on H&S.Given the level of fatalities and injuries and the potential role of the print media, a postal survey was conducted among editors of construction and related magazines. Findings indicate that: the print media do contribute to and play a role in construction H&S; industry has the capacity and needs to promote H&S on a wider basis; there is a need to improve construction H&S; to a degree, editors are aware of what constitutes unsafe acts and unsafe conditions, and the print media can play an increased role through the review of articles, advertisements, advertorial, editorial and phototgraphs to prevent the depiction of unhealthy and unsafe practices and conditions

  2. Synthetic Human β-Globin 5'HS2 Constructs Function as Partially Active Locus Control Regions.

    NARCIS (Netherlands)

    J. Ellis (James); D. Talbot; N.O. Dillon (Niall); F.G. Grosveld (Frank)

    1993-01-01

    textabstractTransgenes linked to the beta-globin locus control region (LCR) are transcribed in a copy-dependent manner that is independent of the integration site. It has previously been shown that the LCR 5'HS2 region does not require its NF-E2 dimer binding site for LCR activity. In this paper we

  3. Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells.

    Science.gov (United States)

    Lee, Hye Min; Moon, Aree

    2016-01-01

    Amygdalin, D-mandelonitrile-β-D-glucoside-6-β-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor agent against breast cancer cells is not clear. The present study aimed to investigate the effect of amygdalin on the proliferation of human breast cancer cells. Here, we show that amygdalin exerted cytotoxic activities on estrogen receptors (ER)-positive MCF7 cells, and MDA-MB-231 and Hs578T triple-negative breast cancer (TNBC) cells. Amygdalin induced apoptosis of Hs578T TNBC cells. Amygdalin downregulated B-cell lymphoma 2 (Bcl-2), upregulated Bcl-2-associated X protein (Bax), activated of caspase-3 and cleaved poly ADP-ribose polymerase (PARP). Amygdalin activated a pro-apoptotic signaling molecule p38 mitogen-activated protein kinases (p38 MAPK) in Hs578T cells. Treatment of amygdalin significantly inhibited the adhesion of Hs578T cells, in which integrin α5 may be involved. Taken together, this study demonstrates that amygdalin induces apoptosis and inhibits adhesion of breast cancer cells. The results suggest a potential application of amygdalin as a chemopreventive agent to prevent or alleviate progression of breast cancer, especially TNBC.

  4. Sons & Lumieres / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2004-01-01

    Näitus "Hääl ja valgus" Pariisi Pompidou keskuses 22. IX 2004-3. I 2005. Väljas on 99 kunstniku (Paul Klee, Frantishek Kupka, Vassili Kandinsky, Laszlo Moholy-Nagy, Raoul Hausmann, Bill Viola, Robert Rauschenberg, Joseph Beuys, Rodney Graham jne.) tööd ajavahemikust 1910-2004. Kuraatorid Sophie Duplaix ja Marcella Lista

  5. Sons & Lumieres / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2004-01-01

    Näitus "Hääl ja valgus" Pariisi Pompidou keskuses 22. IX 2004-3. I 2005. Väljas on 99 kunstniku (Paul Klee, Frantishek Kupka, Vassili Kandinsky, Laszlo Moholy-Nagy, Raoul Hausmann, Bill Viola, Robert Rauschenberg, Joseph Beuys, Rodney Graham jne.) tööd ajavahemikust 1910-2004. Kuraatorid Sophie Duplaix ja Marcella Lista

  6. Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures.

    Directory of Open Access Journals (Sweden)

    Kim Vriens

    Full Text Available Plant defensins are small, cysteine-rich peptides with antifungal activity against a broad range of yeast and fungi. In this study we investigated the antibiofilm activity of a plant defensin from coral bells (Heuchera sanguinea, i.e. HsAFP1. To this end, HsAFP1 was heterologously produced using Pichia pastoris as a host. The recombinant peptide rHsAFP1 showed a similar antifungal activity against the plant pathogen Fusarium culmorum as native HsAFP1 purified from seeds. NMR analysis revealed that rHsAFP1 consists of an α-helix and a triple-stranded antiparallel β-sheet stabilised by four intramolecular disulfide bonds. We found that rHsAFP1 can inhibit growth of the human pathogen Candida albicans as well as prevent C. albicans biofilm formation with a BIC50 (i.e. the minimum rHsAFP1 concentration required to inhibit biofilm formation by 50% as compared to control treatment of 11.00 ± 1.70 μM. As such, this is the first report of a plant defensin exhibiting inhibitory activity against fungal biofilms. We further analysed the potential of rHsAFP1 to increase the activity of the conventional antimycotics caspofungin and amphotericin B towards C. albicans. Synergistic effects were observed between rHsAFP1 and these compounds against both planktonic C. albicans cells and biofilms. Most notably, concentrations of rHsAFP1 as low as 0.53 μM resulted in a synergistic activity with caspofungin against pre-grown C. albicans biofilms. rHsAFP1 was found non-toxic towards human HepG2 cells up to 40 μM, thereby supporting the lack of a general cytotoxic activity as previously reported for HsAFP1. A structure-function study with 24-mer synthetic peptides spanning the entire HsAFP1 sequence revealed the importance of the γ-core and its adjacent regions for HsAFP1 antibiofilm activity. These findings point towards broad applications of rHsAFP1 and its derivatives in the field of antifungal and antibiofilm drug development.

  7. The Use of Postoperative Serum HS-AFP and GGT Ⅱ for Judgment of the Prognosis for Hepatocellular Carcinoma patients

    Institute of Scientific and Technical Information of China (English)

    Runzhou Ni; Lei Yang; Mingbing Xiao; Feng Li; Cuihua Lu

    2006-01-01

    OBJECTIVE To investigate the clinical value of hepatoma-specific alpha-fetoprotein (HS-AFP) and gamma-glutamyltransferase Ⅱ (GGT Ⅱ) for judgment of postoperative prognosis of patients with hepatocellular carcinoma (HCC).METHODS HS-AFP was separated and determined using native polyacrylamide electrophoresis with a discontinuous buffer system and Western blots. GGT Ⅱ was separated with native polyacrylamide electrophoresis with a discontinuous buffer system and detected by enzyme staining. Forty cases with HCC underwent serial determination of HS-AFP and GGT Ⅱ before and after radical excision. The correlations were analyzed between the two indices and survival time.RESULTS In the 40 cases with HCC, before radical excision the positive rates of HS-AFP and GGT Ⅱ were 57.5% and 67.5% respectively, with the positive rate of combined HS-AFP and GGT Ⅱ reaching 80.0%. After operation, the recurrence and metastasis rate in the groups with positive HS-AFP and GGT Ⅱ were 90.9% and 58.8% respectively, while in the groups with negative HS-AFP and GGT Ⅱ the rates were 20.7% and 26.1% respectively. Recurrence and metastasis occurred in all cases with both postoperative positive HS-AFP and GGT Ⅱ but only in 9.5% of the cases in whom both postoperative HS-AFP and GGT Ⅱ were negative. Univariate analysis revealed that postoperative HS-AFP and GGT Ⅱ were related to the prognosis in HCC.CONCLUSION Postoperative serum HS-AFP and GGT Ⅱ are very useful in predicting the prognosis of HCC patients.

  8. Comparative analysis of the aroma chemicals of Melissa officinalis using hydrodistillation and HS-SPME techniques

    Directory of Open Access Journals (Sweden)

    Shakeel-u- Rehman

    2017-05-01

    Full Text Available Headspace solid-phase micro extraction (HS-SPME coupled with gas chromatography–mass spectrometry (GC–MS has been used for the chemical analysis of Melissa officinalis (leaves cultivated in Institute Germplasm. The HS-SPME analysis led to the identification of 22 components constituting 99.1% of the total volatile constituents present in the leaves whereas its hydrodistillate led to the identification of 24 volatile constituents constituting 98.1% of the volatile material. The chemical composition of the SPME and hydrodistilled extract of M. officinalis leaves comprised mainly of oxygenated monoterpenes (78.5% and 57.8% respectively and sesquiterpene hydrocarbons (14.9% and 29.7% respectively. The major components identified in the HS-SPME extract were citronellal (31.1%, citronellol (18.3%, β-caryophyllene (12.0%, (E-citral (11.9%, (Z-citral (9.6%, geraniol (3.6%, (Z-β-ocimene (3.1% and 1-octen-3-ol (2.0% whereas hydrodistilled essential oil was rich in (Z-citral (19.6%, β-caryophyllene (13.2%, (E-citral (11.2%, citronellal (10.2%, germacrene-d (8.3%, δ-3-carene (5.0%, 6-methyl-5-hepten-2-one (3.7% and citronellyl acetate (3.7%. The comparative analysis of volatile constituents of M. officinalis leaf extract using HS-SPME and hydrodistillation techniques shows both qualitative as well as quantitative differences. The current study is the first report involving rapid analysis of volatile components of M. officinalis by HS-SPME.

  9. Post-synthetic regulation of HS structure: the yin and yang of the Sulfs in Cancer

    Directory of Open Access Journals (Sweden)

    Romain R Vives

    2014-01-01

    Full Text Available Heparan sulfate (HS is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array of proteins. These interactions involve saccharide domains of specific sulfation pattern (S-domains, the assembly of which is tightly orchestrated by a highly regulated biosynthesis machinery. Another level of structural control does also take place at the cell surface, where degrading enzymes further modify HS post-synthetically. Amongst them are the Sulfs, a family of extracellular sulfatases (two isoforms in human that catalyze the specific 6-O-desulfation of HS. By targeting HS functional sulfated domains, Sulfs dramatically alter its ligand binding properties, thereby modulating a broad range of signaling pathways. Consequently, Sulfs play major roles during development, as well as in tissue homeostasis and repair. Sulfs have also been associated with many pathologies including cancer, but despite increasing interest, the role of Sulfs in tumor development still remains unclear. Studies have been hindered by a poor understanding of the Sulf enzymatic activities and conflicting data have shown either anti-oncogenic or tumor-promoting effects of these enzymes, depending on the tumor models analyzed. These opposite effects clearly illustrate the fine tuning of HS functions by the Sulfs, and the need to clarify the mechanisms involved. In this review, we will detail the present knowledge on the structural and functional properties of the Sulfs, with a special focus on their implication during tumor progression. Finally, we will discuss attempts and perspectives of using the Sulfs as a biomarker of cancer prognosis and diagnostic and as a target for anti-cancer therapies.

  10. Unstable Angina Pectoris Patients Serum hs-CRP Levels in Clinical Research%不稳定心绞痛患者血清hs-CRP水平临床研究

    Institute of Scientific and Technical Information of China (English)

    易慧芳

    2014-01-01

    Objective Investigate al ergic hs CRP determination in patients with unstable angina pectoris diagnosis value of serum. Methods Choose 60 cases of unstable angina pectoris patients as observation group, In the treatment of day 1, day 15 test hs-CRP concentration in serum, select 60 outpatient patients with stable angina pectoris patients as control group. Results Group of patients with unstable angina pectoris patients serum hs- CRP concentration significantly increased, compared with the control group with very significant dif erence( P<0.05 ) ,Observation group in the treatment of before and after comparison, hs-CRP concentration in serum increased obviously, there are significant dif erences(P<0.05). Conclusion The hs-CRP significantly higher in patients with unstable angina pectoris, has a high diagnostic value.%目的:探讨超敏C反应蛋白( High sensitivity C Reactive Protein,hs-CRP )测定在不稳定心绞痛患者血清中的诊断价值。方法选取60例不稳定心绞痛患者作为观察组,在入院第1d、第15d检测血清中hs-CRP浓度,选取门诊稳定心绞痛患者60例作为对照组。结果不稳定心绞痛患者患者组血清中hs-CRP浓度明显增高,与对照组比较有非常显著性差异(P<0.05),观察组在治疗前、后比较,血清中hs-CRP浓度明显增高,有显著性差异(P<0.05)。结论 hs-CRP在不稳定心绞痛患者中显著增高,有很高的诊断价值。

  11. ROS-Dependent Neuroprotective Effects of NaHS in Ischemia Brain Injury Involves the PARP/AIF Pathway

    Directory of Open Access Journals (Sweden)

    Qian Yu

    2015-07-01

    Full Text Available Background/Aims: Stroke is among the top causes of death worldwide. Neuroprotective agents are thus considered as potentially powerful treatment of stroke. Methods: Using both HT22 cells and male Sprague-Dawley rats as in vitro and in vivo models, we investigated the effect of NaHS, an exogenous donor of H2S, on the focal cerebral ischemia-reperfusion (I/R induced brain injury. Results: Administration of NaHS significantly decreased the brain infarcted area as compared to the I/R group in a dose-dependent manner. Mechanistic studies demonstrated that NaHS-treated rats displayed significant reduction of malondialdehyde content, and strikingly increased activity of superoxide dismutases and glutathione peroxidase in the brain tissues compared with I/R group. The enhanced antioxidant capacity as well as restored mitochondrial function are NaHS-treatment correlated with decreased cellular reactive oxygen species level and compromised apoptosis in vitro or in vivo in the presence of NaHS compared with control. Further analysis revealed that the inhibition of PARP-1 cleavage and AIF translocation are involved in the neuroprotective effects of NaHS. Conclusion: Collectively, our results suggest that NaHS has potent protective effects against the brain injury induced by I/R. NaHS is possibly effective through inhibition of oxidative stress and apoptosis.

  12. Elevated Preoperative Serum Hs-CRP Level as a Prognostic Factor in Patients Who Underwent Resection for Hepatocellular Carcinoma.

    Science.gov (United States)

    Liu, Yu-Bin; Ying, Jie; Kuang, Su-Juan; Jin, Hao-Sheng; Yin, Zi; Chang, Liang; Yang, Hui; Ou, Ying-Liang; Zheng, Jiang-Hua; Zhang, Wei-Dong; Li, Chuan-Sheng; Jian, Zhi-Xiang

    2015-12-01

    To evaluate the effects of preoperative highly sensitive C-reactive protein (Hs-CRP) in serum on the prognostic outcomes of patients with hepatocellular carcinoma (HCC) following hepatic resection in Chinese samples.From January 2004 to December 2008, a total of 624 consecutive HCC patients who underwent hepatic resection were incorporated. Serum levels of Hs-CRP were tested at preoperation via a collection of venous blood samples. Survival analyses adopted the univariate and multivariate analyses.In our study, among the 624 screened HCC patients, 516 patients were eventually incorporated and completed follow-up. Positive correlations were found regarding preoperative serum Hs-CRP level and tumor size, Child-Pugh class, or tumor stage (all P Hs-CRP levels at preoperation (both P Hs-CRP-normal group, the overall survival (OS) and recurrence-free survival rates were evidently decreased in the Hs-CRP-elevated group. Further, preoperative serum Hs-CRP level might be having possible prediction effect regarding survival and recurrence of HCC patients after hepatic section in the multivariate analysis.Preoperative increased serum Hs-CRP level was an independent prognostic indicator in patients with HCC following hepatic resection in Chinese samples.

  13. Correlation of Serum Levels of Vitronectin, Malondialdehyde and Hs-CRP With Disease Severity in Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Alireza Yaghoubi

    2015-09-01

    Conclusion: The association and correlation between VN, MDA and hs-CRP indicate their involvement in the atherosclerosis process that may lead to progression of CAD. Also, these findings suggested that serum levels of VN, MDA and hs-CRP can help as diagnostic and monitoring markers in CAD patients and as markers of disease severity.

  14. The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning

    NARCIS (Netherlands)

    Wolthuis, O.L.; Clason-van der Wiel, H.J.; Visser, R.P.L.S.

    1976-01-01

    Atropinised anaesthetised rats were injected i.v. with 4, 6 or 8 x LD50 of the organophosphorous anticholinesterase soman. Subsequent treatment with one dose of HS 6 (100 mg/kg, i.v.) delayed respiratory failure by 1 h or more; a further postponement was obtained when an additional HS 6 infusion was

  15. Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation.

    Science.gov (United States)

    Kahner, Bryan N; Dorsam, Robert T; Mada, Sripal R; Kim, Soochong; Stalker, Timothy J; Brass, Lawrence F; Daniel, James L; Kitamura, Daisuke; Kunapuli, Satya P

    2007-10-01

    Collagen activates platelets through an intracellular signaling cascade downstream of glycoprotein VI (GPVI). We have investigated the contribution of hematopoietic lineage cell-specific protein 1 (HS1) downstream of GPVI in platelet activation. Stimulation of GPVI leads to tyrosine phosphorylation of HS1, which is blocked by Src-family kinase inhibitors. Coimmunoprecipitation experiments revealed that HS1 associates with Syk and phosphatidylinositol 3-kinases. HS1-null mice displayed increased bleeding times and increased time to occlusion in the FeCl(3) in vivo thrombosis model compared with their wild-type littermates. In addition, aggregation and secretion responses were diminished in HS1-null mouse platelets after stimulation of GPVI and protease-activated receptor 4 (PAR-4) agonists compared with wild-type littermate mouse platelets. Finally, Akt phosphorylation was diminished after GPVI or PAR-4 stimulation in platelets from HS1-null mice compared with their wild-type littermates. These results demonstrate that phosphorylation of the HS1 protein occurs downstream of GPVI stimulation and that HS1 plays a significant functional role in platelet activation downstream of GPVI and PARs.

  16. Proteomic Comparison of Fruit Ripening between 'Hedelfinger' Sweet Cherry (Prunus avium L.) and Its Somaclonal Variant 'HS'.

    Science.gov (United States)

    Prinsi, Bhakti; Negri, Alfredo S; Espen, Luca; Piagnani, M Claudia

    2016-05-25

    The somaclonal variant HS, from sweet cherry (Prunus avium L.) 'Hedelfinger' (H), was previously selected for reduced tree vegetative vigor and lesser canopy density. In this work, we compared H and HS fruits at early unripe (green) and full ripe (dark red) stages by biochemical and proteomic approaches. The main biochemical parameters showed that fruit quality was not affected by somaclonal variation. The proteomic analysis identified 39 proteins differentially accumulated between H and HS fruits at the two ripening stages, embracing enzymes involved in several pathways, such as carbon metabolism, cell wall modification, stress response, and secondary metabolism. The evaluation of fruit phenolic composition by mass spectrometry showed that HS sweet cherries have higher levels of procyanidin, flavonol, and anthocyanin compounds. This work provides the first proteomic characterization of fruit ripening in sweet cherry, revealing new positive traits of the HS somaclonal variant.

  17. Analysis of the changes of serum lipid and hs-CRP in patients with subclinical hypothyroidism

    Institute of Scientific and Technical Information of China (English)

    Jin-Mian Fan; Dong-Bo Zheng; Zhou-Ping Zhang

    2016-01-01

    Objective:To analyze changes of serum lipid and hs-CRP levels in patients with subclinical hypothyroidism in order to explore their correlations with TSH level.Methods:A total of 90 patients with subclinical hypothyroidism were included in the study and divided into the mild, moderate, and severe groups according to TSH level with 30 cases in each group; meanwhile, 30 healthy individuals were served as the control groups. The changes of the levels of TSH, serum lipid indicators (TC, TG, HDL-C, LDL-C, ApoA, ApoB, and Lpa), and hs-CRP in the four groups were observed. The correlation of serum lipid and hs-CRP with TSH was analyzed. Results: The levels of TSH, TC, TG, Lpa, and hs-CRP in the subclinical hypothyroidism subgroups were significantly higher than those in the control group. The levels of HDL-C, LDL-C, ApoA, and ApoB in patients with subclinical hypothyroidism were increased when compared with the control group. The levels of HDL-C, LDL-C, and ApoB in the moderate and severe groups were significantly higher than those in the control group. ApoA level in the severe group was significantly higher than that in the control group. LDL-C in the moderate group was significantly higher than that in the mild group, and that in the severe group was significantly higher than that in the moderate group. ApoB level in the severe group was significantly higher than that in the mild group. Spearman correlation analysis showed that TC, TG, LDL-C, ApoB, Lpa, and hs-CRP were positively correlated with TSH level, while HDL-C and ApoA had no correlation with TSH level.Conclusions:The levels of serum lipid and hs-CRP are abnormally elevated in patients with subclinical hypothyroidism, and are gradually increased along with the disease progression, which is closely associated with TSH level.

  18. hsCRP in pre-hypertension and hypertension: a prospective study in Southern Asian region

    Directory of Open Access Journals (Sweden)

    Satwika Sinha

    2014-08-01

    Full Text Available Background: Hypertension is turned into a leading cause of non-communicable disease associated mortality and morbidity in both developing as well as developed world. Hypertension is reported to be the fourth contributor to premature death in developed countries and the seventh in developing countries. In the regard of early diagnosis and better prognosis, the concept of pre-hypertension, defined as a systolic blood pressure of 120-139 mmHg and/or a diastolic blood pressure of 80-89 mmHg was introduced as the new guideline for the management of blood pressure by the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC-7. Among various other factors inflammation may be a causative factor for development of Hypertension But the association is not very clear. Accordingly, we have designed our study to find any association of hsCRP with pre-hypertension and hypertension so that early prevention and control can help to avoid or delay the grave outcome and complications of hypertension. Methods: A total of 37 hypertensives, 30 pre-hypertensives and 31 age and sex matched healthy control subjects were selected for the study, with consent. Two BP readings were taken five minutes apart, on both arms, with a mercury sphygmomanometer. The estimation of serum hsCRP was done on XL-600 automatic analyzer with the kit (Erba Mannheim based on the measurement of antigen-antibody reaction by the end-point method. Results: There is significant difference in systemic and diastolic blood pressure and hsCRP in between group study. In pre-hypertensive group hsCRP is correlated with diastolic blood pressure. Conclusion: Our results suggest a correlation exists between hsCRP and hypertension more significantly with pre-hypertension. So estimation of serum hsCRP can be a good diagnostic as well as prognostic marker in diagnosing pre-hypertensives and prevent the occurance of hypertension and cardio

  19. Rezension von: Karin Schwiter: Lebensentwürfe. Junge Erwachsene im Spannungsfeld zwischen Individualität und Geschlechternormen. Frankfurt am Main u.a.: Campus Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Heike Kahlert

    2011-10-01

    Full Text Available Karin Schwiter untersucht in der vorliegenden Studie, wie junge Erwachsene über ihre Zukunftspläne sprechen und welche Vorstellungen bezüglich ihrer Zukunft sie dabei entwerfen. Die Untersuchung zeichnet sich gegenüber älteren Forschungen zu diesem Thema unter anderem aus durch einen Geschlechtervergleich, die raumzeitliche Fokussierung auf die Deutschschweiz sowie ein diskursanalytisches Vorgehen in Anlehnung an Foucault. Das Ergebnis ist ein anregendes Buch, in dem die Autorin auf der Basis der Erzählungen von 24 jungen Frauen und Männern gesellschaftstheoretische Deutungen und Ausblicke entwickelt. Diese belegen, wie sich neoliberale Ideen von Individualität und fortbestehende Geschlechternormen miteinander so verschränken, dass Thematisierungen geschlechtlicher Ungleichheit kaum mehr möglich scheinen.

  20. A revolution of the mind: some implications of George Hogenson's 'The Baldwin Effect: a neglected influence on C.G. Jung's evolutionary thinking' (2001).

    Science.gov (United States)

    Colman, Warren

    2015-09-01

    George Hogenson's 2001 paper 'The Baldwin Effect: a neglected influence on C.G. Jung's evolutionary thinking' developed the radical argument that, if archetypes are emergent, they 'do not exist in the sense that there is no place that the archetypes can be said to be'. In this paper, I show how Hogenson's thinking has been seminal to my own: it is not just archetypes but the mind itself that has no 'place'. The mind is a dynamic system, emergent from the cultural environment of symbolic meanings to which humans are evolutionarily adapted. Drawing on the work of philosopher John Searle, I argue that symbols constitute the realities that they bring forth, including the imaginal realities of the psyche. The implications for clinical work include a rejection of structural models of the psyche in favour of the emergence of symbolic realities in the context of psychoanalysis as a distributed system of cognition. © 2015, The Society of Analytical Psychology.

  1. Performance Analysis of an Enhanced PRMA-HS Protocol for LEO Satellite Communication

    Institute of Scientific and Technical Information of China (English)

    ZHUO Yong-ning; YAN Shao-hu; WU Shi-qi

    2005-01-01

    The packet reservation multiple access with hindering state (PRMA-HS) is a protocol suitable for LEO satellite mobile communication. Although working well with light system payload (amount of user terminals), the protocol imposes high channel congestion on system with heavy payload, thus degrades the system's quality of service. To controlling the channel congestion, a scheme of enhanced PRMA-HS protocol is proposed, which aims to reduce the collision of voice packets by adopting a mechanism of access control. Through theoretic analysis, the system's mathematic model is presented and the packet drop probability of the scheme is deduced. To testify the performance of the scheme, a simulation is performed and the results support our analysis.

  2. The e-NutriHS: a web-based system for a Brazilian cohort study.

    Science.gov (United States)

    Folchetti, Luciana D; da Silva, Isis T; de Almeida Pititto, Bianca; Ferreira, Sandra R G

    2015-01-01

    The e-NutriHS is a web-based system developed to gather online information on health of a cohort of college students and graduates in nutrition. It consists of six validated and internationally recognized questionnaires regarding demographic and socioeconomic data, dietary habits, physical activity level, alcohol and tobacco use, anti-fat attitudes and personal and family histories. Our software and respective database is hosted in the School of Public Health server and is based on free programming languages. An e-NutriHS prototype was created preceding online deployment. An improved version of the website was released based on 20 volunteers' opinions. A total of 503 users were registered. Considering that web-based systems produce reliable data, are easy to use, less costly and are less time-consuming, we conclude that our experience deserves to be shared, particularly with middle income economy countries.

  3. Sulfur isotope effects associated with protonation of HS- and volatilization of H2S

    Science.gov (United States)

    Fry, B.; Gest, H.; Hayes, J. M.

    1986-01-01

    The isotope effects associated with: (1) formation of H2S from HS- by protonation in aqueous solution; and (2) volatilization of H2S have been experimentally determined. Both isotopic distributions in closed systems at equilibrium and differential rates of volatilization of isotopic species in open systems were measured at 22 +/- 1 degrees C. It was found that, at equilibrium aqueous H2S is enriched in 34S by 2.0 - 2.7% relative to HS- and that H2S volatilized from solution is depleted in 34S by 0.5% relative to dissolved H2S. A small kinetic isotope effect accompanying volatilization of H2S was observed in the open-system experiments.

  4. 弗洛伊德、荣格与阿德勒的释梦观比较%Comparison on Dream Interpretation Theories from Freud, Jung and Adler

    Institute of Scientific and Technical Information of China (English)

    徐凯

    2016-01-01

    Dream interpretation is a classic technique of psychoanalysis. As the pioneers of dream interpretation, Freud, Jung and Adler have fundamentally changed perceptions about dream, furnished a whole new dimension for dream interpretation, and guided the direction of dream theories. Although Freud, Jung and Adler’s dream interpretation theories were all built on the theory of unconscious, and regarded dreams as the fast track to unconscious, they had different understandings on the nature, function, mechanism and analytic methods of dream. We should treat their dream theories differently in order to serve the practice of dream interpretation better.%释梦是精神分析的经典技术。其先驱者弗洛伊德、荣格和阿德勒从根本上改变了人们对梦的看法,开创了―个全新的心理学领域,在梦的元理论思想上一直指导着后世释梦的走向。尽管弗洛伊德、荣格与阿德勒的释梦观都建立在对无意识理解的基础上,都认可梦是通往无意识的捷径,但他们在梦的本质、功能、工作机制和解析方法上却有着不同的理解,在实践应用中也应加以区分对待,以便服务于当下的释梦实践。

  5. Sucrose Octaacetate Chemical Kinetics and Shelf Lives at Various Formulation pHs.

    Science.gov (United States)

    Gaddam, Shalini; Stagner, William C

    2017-06-23

    Developing pediatric friendly dosage forms is a high priority worldwide. Sucrose octaacetate (SOA) has been recommended for use as a surrogate for bitter tasting active pharmaceutical ingredients. Even though SOA has found a number of human use applications and has been employed for decades, there are no rigorous chemical kinetic studies reported. A recently reported SOA stability-indicating method was used to perform SOA chemical kinetic and stability studies. As part of the chemical kinetic study, reaction order, activation energies, extrapolated rate constants, pH-rate profiles at 4 and 25°C, and estimated shelf lives at 4 and 25°C at different buffer pHs are provided. The estimated SOA shelf lives at 25°C and pHs 4.00, 5.20, and 6.00 were 25.3, 114, and 27.4 days, respectively. At 4°C, SOA's estimated shelf lives were 0.478, 5.26, and 1.47 years at pHs 4.00, 5.20, and 6.00, respectively. SOA can be formulated at pHs 4 to 6 and stored at 25°C for short-duration (less than 25 days) uses such as a bitter tasting surrogate for fundamental taste mechanism studies or brief taste masking assessment clinical studies. For longer term solution studies, like being used as a bitter tasting control for blinded clinical trials, SOA should be formulated at the optimum pH of 5.40 and refrigerated at 4°C for maximum stability. The reported data can be used as a starting point for developing stable SOA formulations and estimating shelf life.

  6. A New Compound Along With Seven Known Compounds from an Endophytic Fungus Aspergillus sp. HS-05

    Directory of Open Access Journals (Sweden)

    Gang Chen

    2013-08-01

    Full Text Available Investigation of EtOAc extract from the fermentation broth of the endophytic fungus Asperilligus sp. HS-05 led to the isolation of a new compound (1 of spiro moiety named aspergispiroketal and seven known compounds (2-8. Their structures were elucidated mainly by NMR and HR-TOF-MS, as well as on comparison with the reported data. The absolute configuration of 1 was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.

  7. Linear and Nonlinear Optical Characterization of PolyDCHD-HS Films

    Institute of Scientific and Technical Information of China (English)

    CHEN Xianfeng; XIE Shengwu; CHEN Yingli; XIA Yuxin; S. Stefano; E. Giorgetti; G. Margatti

    2000-01-01

    Waveguiding films of the highly soluble polycarbazolydiacetylene polyDCHD-HS were prepared by spin coating and characterized at different wavelengths: 5 dB/cm propagation losses were observed at 1321 nm.Measurements of the third order nonliearity at 1064nm with the surface plasmon resonance method gave the valueχ(3)= i4.4×10-17+3.5×10-18 m2/V2.

  8. Right-invariant Sobolev metrics ${H}^{s}$ on the diffeomorphisms group of the circle

    CERN Document Server

    Escher, Joachim

    2012-01-01

    We study the geodesic flow on the diffeomorphisms group of the circle with respect to the right-invariant metric induced by the fractional Sobolev norm $H^s$ for $s\\ge1/2$. We show that the corresponding initial value problem possesses a maximal solution in the smooth category and that the Riemannian exponential mapping is a smooth diffeomorphism from a neighbourhood of 0 in $C^{\\infty}(S)$ onto a neighbourhood of the identity in $Diff^{\\infty}(S)$.

  9. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

    OpenAIRE

    Rune Brautaset; Ulrika Birkeldh; Petra Frehr Alstig; Petra Wikén; Maria Nilsson

    2016-01-01

    Background Optical coherence tomography (OCT), can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance. Methods Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS10...

  10. 慢性心力衰竭患者血清MMP-9和hs-CRP的表达%Expressions of serum MMP-9 and hs-CRP in patients with chronic heart failure

    Institute of Scientific and Technical Information of China (English)

    郑利平

    2012-01-01

    Objective To investigate the changes of serum matrix metalloproteinase-9(MMP-9) and high sensitive Creactive protein(hs-CRP) expressions in the patients with chronic heart failure (CHF). Methods A total of 120 CHF patients was divided into 4 groups according to NYHA cardiac function classes of Ⅰ ,Ⅱ , Ⅲ and Ⅳ. The expression levels of MMP-9 and hs-CRP were detected with ELISA and Latex enhanced immunoturbidimetric assay, respectively, and compared among 4 NYHA cardiac cardiac function classes. Results The expression levels of MMP-9 and hs-CRP were increased as the cardiac function became worsen(P<0. 05). The expression of serum MMP-9 was positively correlated to that of hs-CRP(r=0. 716,P<0. 01). Conclusion When the cardiac dysfunction becomes severe in CHF patients,the expressions of MMP-9 and hs-CRP are remarkably increased, which may participate in the myocardial remodeling of CHF.%目的 探讨基质金属蛋白酶9(MMP-9)和高敏C反应蛋白(hs-CRP)在慢性心力衰竭(CHF)患者的表达.方法 CHF患者120例,ELISA检测血清MMP-9表达,乳胶增强免疫比浊法检测血清hs-CRP水平.比较不同NYHA心功能状态患者MMP-9和hs-CRP的表达差异.结果 随着心功能的恶化,MMP-9和hs-CRP的表达水平显著升高(P<0.05).CHF患者外周血MMP-9和hs-CRP的表达水平呈正相关(r=0.716,P<0.01).结论 CHF患者外周血MMP-9和hs-CRP表达水平随着心功能的减低而升高,MMP-9和hs-CRP表达可能参与了CHF心肌重构的病理过程.

  11. Interference of anesthetics in blood alcohol analysis by HS-GC-FID: A case report.

    Science.gov (United States)

    Monteiro, C; Proença, P; Tavares, C; Castañera, A; Corte Real, F

    2016-08-01

    One of the techniques most widely used in ethanol analysis in forensic laboratories is undoubtedly the headspace gas chromatography with flame-ionization detection (HS-GC-FID) since the determination of this substance is carried out directly, without the need for additional purification procedures, which leads to increased productivity. This is a very important factor due to the high number of alcohol analysis requested to these laboratories. The presence of other volatile substances can cause a problem given the fact that they can be interferents in ethanol analysis by HS-GC-FID, which can have legal consequences related with driving under the influence of alcohol. The authors report a case of a routine analysis by HS-GC-FID for the determination of ethanol of a driver who has suffered an accident in which the use of two chromatographic columns with different polarities was essential to obtain an unequivocally identification of this substance in presence of an interfering volatile anesthetic administered in the hospital. The method was validated according to international recommendations before being introduced into routine laboratory in terms of selectivity, limits of detection (LOD), limits of quantification (LOQ), linearity, repeatability, intermediate precision, accuracy, robustness and carryover.

  12. Infrared Studies of the Reflective Properties of Solar Cells and the HS376 Spacecraft

    Science.gov (United States)

    Frith, James; Reyes, Jacqueline; Cowardin, Heather; Anz-Meador, Phillip; Buckalew, Brent; Lederer, Susan

    2016-01-01

    In 2015, a selection of HS-376 buses were observed photometrically with the United Kingdom Infrared Telescope (UKIRT) to explore relationships between time-on-orbit and Near Infrared (NIR) color. These buses were chosen because of their relatively simple shape, for the abundance of similar observable targets, and their surface material being primarily covered by solar cells. While the HS-376 spacecraft were all very similar in design, differences in the specific solar cells used in the construction of each model proved to be an unconstrained variable that could affect the observed reflective properties. In 2016, samples of the solar cells used on various models of HS-376 spacecraft were obtained from Boeing and were analyzed in the Optical Measurements Center at the Johnson Space Center using a visible-near infrared field spectrometer. The laboratory-based spectra are convolved to match the photometric bands previously obtained using UKIRT and compared with the on-orbit photometry. The results and future work are discussed here.

  13. Correlation of Progranulin, Granulin, Adiponectin and Vaspin with Metaflammation (hs-CRP in Indonesian Obese Men

    Directory of Open Access Journals (Sweden)

    Rosalia E Napitupulu

    2013-08-01

    Full Text Available BACKGROUND: Obesity is closely related to chronic, low grade systemic inflammation (metaflammation and it leads to further metabolic complications such as hypertension, atherosclerosis, and type 2 diabetes due to the adipocytokine imbalance. This study was carried out to assess the correlation between progranulin, granulin, adiponectin and visceral adipose tissue-derived serine protease inhibitor (Vaspin with metaflammation (high sensitivity C-reactive protein (hs-CRP in centrally obese men. METHODS: This study was observational with a cross sectional design involving 60 men aged 30-60 years, consisted of 43 obese men (waist circumference (WC ≥90 cm and 13 non obese men (WC 105 cm. CONCLUSIONS: We found metaflammation (hs-CRP was significantly correlated with Vaspin, but not with progranulin, granulin and adiponectin, in obese men. We suggest the possibility of a dynamic expression of adipokines related to WC that are subjected to adipocytes hypertrophy-hyperplasia phenomenon. KEYWORDS: progranulin, granulin, adiponectin, Vaspin, hs-CRP, metaflammation, central obesity.

  14. Correlation of hs-CRP with environmental risk factors of nephropathy in type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Jay Prakash Sah

    2015-06-01

    Full Text Available The objective of the present study was to investigate the association of hs-CRP levels with environmental risk factors of diabetic nephropathy like smoking, drinking alcohol, diet, age of diabetic patient, duration of diabetes, medication of diabetes, and blood pressure medication. A hospital-based quantitative study was conducted at the Department of Clinical Biochemistry of Manipal Teaching Hospital (MTH Pokhara, Nepal, with 89 patients suffering from type 2 diabetes. Blood samples (n=89 from the patients were collected and the serums were separated. On the other hand, data on environmental risk factors of nephropathy were collected by using standard questionnaire. In this study, serum hs-CRP level was not found to be correlated with smoking (p=0.111, alcohol consumption (p=0.722, diet (p=0.496, duration of diabetes (p=0.519, age of diabetic patient (p=0.369, medication of diabetes (p=0.734, and blood pressure medication (p=0.625. Hence, our study concludes that serum hs-CRP value in type 2 diabetic patients is insignificantly correlated with the risk factors especially smoking, drinking alcohol, diet, duration of diabetes, age of diabetic patient, medication of diabetes, and medication of blood pressure.

  15. Hyperphosphatemia and hs-CRP Initiate the Coronary Artery Calcification in Peritoneal Dialysis Patients.

    Science.gov (United States)

    Shang, Da; Xie, Qionghong; Shang, Bin; Zhang, Min; You, Li; Hao, Chuan-Ming; Zhu, Tongying

    2017-01-01

    Background. Coronary artery calcification (CAC) contributes to high risk of cardiocerebrovascular diseases in dialysis patients. However, the risk factors for CAC initiation in peritoneal dialysis (PD) patients are not known clearly. Methods. Adult patients with baseline CaCS = 0 and who were followed up for at least 3 years or until the conversion from absent to any measurable CAC detected were included in this observational cohort study. Binary logistic regression was performed to identify the risk factors for CAC initiation in PD patients. Results. 70 patients recruited to our study were split into a noninitiation group (n = 37) and an initiation group (n = 33) according to the conversion of any measurable CAC during their follow-up or not. In univariate analysis, systolic blood pressure, serum phosphorus, fibrinogen, hs-CRP, serum creatinine, and triglycerides were positively associated with the initiation of CAC, while the high density lipoprotein and nPCR did the opposite function. Multivariate analysis revealed that hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation after adjustments. Conclusions. Hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation in PD patients. These results suggested potential clinical strategies to prevent the initiation of CAC in PD patients.

  16. The relationship of urotensin II with insulin resistance and hs-CRP in patients having PCOS.

    Science.gov (United States)

    Yilmaz, Özgür; Calan, Ozlem; Kume, Tuncay; Calan, Mehmet

    2013-11-01

    UrotensinII (UII), one of the most potent vasoconstrictor proteins, may be associated with insulin resistance. The objective of our research was to determine the level of UII in sera of patients with PCOS and to investigate the relationship between UII and insulin resistance in patients with PCOS. Fourty seven PCOS patients and 42 healthy women were included in the study. Serum fasting glucose, insulin, UII, free testosterone and hs-CRP levels of the patients were examined. The HOMA-IR formula was used to calculate insulin resistance. Insulin sensitivity was calculated by using the QUICKI-IS formula. The two groups did not show any a significant difference in terms of age and BMI (p > 0.05). Serum UII, hs-CRP, insulin levels and the HOMA-IR were significantly higher in the patients with PCOS (p hs-CRP(r = 0.51, p < 0.001). Our study data suggested that UII may have a role in the pathophysiology of insulin resistance and increased cardiovascular risk, which are commonly found in patients with PCOS.

  17. Rapid discrimination and feature extraction of three Chamaecyparis species by static-HS/GC-MS.

    Science.gov (United States)

    Chen, Ying-Ju; Lin, Chun-Ya; Cheng, Sen-Sung; Chang, Shang-Tzen

    2015-01-28

    This study aimed to develop a rapid and accurate analytical method for discriminating three Chamaecyparis species (C. formosensis, C. obtusa, and C. obtusa var. formosana) that could not be easily distinguished by volatile compounds. A total of 23 leaf samples from three species were analyzed by static-headspace (static-HS) coupled with gas chromatography-mass spectrometry (GC-MS). The static-HS procedure, whose experimental parameters were properly optimized, yielded a high Pearson correlation-based similarity between essential oil and VOC composition (r = 0.555-0.999). Thirty-six major constituents were identified; along with the results of cluster analysis (CA), a large variation in contents among the three different species was observed. Principal component analysis (PCA) methods illustrated graphically the relationships between characteristic components and tree species. It was clearly demonstrated that the static-HS-based procedure enhanced greatly the speed of precise analysis of chemical fingerprint in small sample amounts, thus providing a fast and reliable tool for the prediction of constituent characteristics in essential oil, and also offering good opportunities for studying the role of these feature compounds in chemotaxonomy or ecophysiology.

  18. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction.

    Science.gov (United States)

    Wang, Ke-Sheng; Wang, Liang; Liu, Xuefeng; Zeng, Min

    2013-12-01

    The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides). We examined genetic associations of 117 single-nucleotide polymorphisms (SNPs) within the HS6ST3 gene with obesity and triglycerides using two Caucasian samples: the Marshfield sample (1442 obesity cases and 2122 controls), and the Health aging and body composition (Health ABC) sample (305 cases and 1336 controls). Logistic regression analysis of obesity as a binary trait and linear regression analysis of triglycerides as a continuous trait, adjusted for age and sex, were performed using PLINK. Single marker analysis showed that six SNPs in the Marshfield sample and one SNP in the Health ABC sample were associated with obesity (P triglycerides in the Marshfield sample (P triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.

  19. Exploring Dust Impacts on Tropical Systems from the NASA HS-3 Field Campaign

    Science.gov (United States)

    Nowottnick, Ed; Colarco, Pete; da Silva, Arlindo; Barahona, Donifan; Hlavka, Dennis

    2015-01-01

    One of the overall scientific goals of the NASA Hurricane and Severe Storm Sentinel (HS-3) field campaign is to better understand the role of the Saharan Air Layer (SAL) in tropical storm development. During the 2012 HS-3 deployment, the Cloud Physics Lidar (CPL) observed dust within SAL air in close proximity to a developing Nadine (September 11, 2012). Throughout the mission, the NASA GEOS-5 modeling system supported HS-3 by providing 0.25 degrees resolution 5-day global forecasts of aerosols, which were used to support mission planning. The aerosol module was radiatively interactive within the GEOS-5 model, but aerosols were not directly coupled to cloud and precipitation processes. In this study we revisit the aerosol forecasts with an updated version of the GEOS-5 model. For the duration of Hurricane Nadine, we run multiday climate simulations leading up to each respective Global Hawk flight with and without aerosol direct interaction. For each set of simulations, we compare simulated dust mass fluxes to identify differences in SAL entrainment related to the interaction between dust aerosols and the atmosphere. We find that the direct effects of dust induce a low level anticyclonic circulation that temporarily shields Nadine from the intrusion of dry air, leading to a more intense storm.

  20. Inhibitory effects of HS014 on glutamate release in astrocytes chronically treated with morphine

    Institute of Scientific and Technical Information of China (English)

    Haichen Chu; Zejun Niu; Zhao Yang; Xuefeng Zhang

    2010-01-01

    Previous studies have confirmed that the number of glial fibrillary acidic protein-positive cells significantly increases during morphine tolerance.However,morphine tolerance is reversed with melanocortin receptor antagonists,and analgesic action is enhanced accordingly.However,these mechanisms remain unclear.In the present study,following addition of morphine to Wistar rat spinal cord astrocytes,glutamate levels in the supematant significantly increased(P<0.05).At 30-120minutes following addition of intervention agent to spinal cord astrocytes,naloxone significantly increased glutamate release in morphine-tolerant model cells(P < 0.05),while melanocortin receptor antagonist HS014 decreased glutamate release(P < 0.05).Additional naloxone and HS014 to astrocytes significantly decreased glutamate release compared with additional naloxone alone(P < 0.01).Results from the present study demonstrated that glutamate release was increased in spinal cord astrocytes co-cultured with morphine.Naloxone increased glutamate release,and HS014 reduced glutamate release.

  1. Relationship Between the Hypersensitive c-Reactive Protein (hs-CRP) Level and the Prognosis of Acute Brainstem Infarction.

    Science.gov (United States)

    Zhang, Xia; Huang, Wen-Juan; Yu, Zhi-Gang

    2015-05-01

    The objective of this study is to explore the relationship between the hypersensitive c-reactive protein (hs-CRP) level and the prognosis of acute brainstem infarction. Serum levels of hs-CRP were measured in 68 patients with acute brainstem infarction 72 h after disease onset. The hs-CRP levels in the U.S. National Institutes of Health Stroke Scale (NIHSS) score group and in the modified RANKIN scale (mRS) score group were compared. The independent risk factors of brainstem infarction were analyzed using Logistic binary regression. The hs-CRP level was significantly higher in the group with NIHSS >5 compared with the one with NIHSS ≤ 5 (P = 0.004). In the group with mRS > 2, the age, smoking history, and blood glucose level were significantly higher than those in the group with mRS ≤ 2 (P hs-CRP level was significantly higher (P = 0.001). Age and hs-CRP level were the independent prognostic factors of the brainstem infarction. The serum hs-CRP level is closely related with the severity and prognosis of brainstem infarction, and is an independent risk factor of acute brainstem infarction.

  2. High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men

    Science.gov (United States)

    Lee, Jieun; Yoon, Kijung; Ryu, Seungho; Chang, Yoosoo; Kim, Hyoung-Ryoul

    2017-01-01

    We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001). As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development. PMID:28234943

  3. The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing

    Science.gov (United States)

    Walters, Mark C.; Fiering, Steven; Bouhassira, Eric E.; Scalzo, David; Goeke, Scott; Magis, Wendy; Garrick, David; Whitelaw, Emma; Martin, David I. K.

    1999-01-01

    A constitutive DNase I-hypersensitive site 5′ of the chicken β-globin locus, termed 5′HS4 or cHS4, has been shown to insulate a promoter from the effect of an upstream enhancer and to reduce position effects on mini-white expression in Drosophila cells; on the basis of these findings, it has been designated a chromatin insulator. We have examined the effect of the cHS4 insulator in a system that assays both the level of gene expression and the rate of transcriptional silencing. Because transgenes flanked by insulator elements are shielded from position effects in Drosophila cells, we tested the ability of cHS4 to protect transgenes from position effects in mammalian cells. Flanking of an expression vector with the cHS4 insulator in a colony assay did not increase the number of G418-resistant colonies. Using lox/cre-based recombinase-mediated cassette exchange to control integration position, we studied the effect of cHS4 on the silencing of an integrated β-geo reporter at three genomic sites in K562 erythroleukemia cells. In this assay, enhancers act to suppress silencing but do not increase expression levels. While cHS4 blocked enhancement at each integration site, the strength of the effect varied from site to site. Furthermore, at some sites, cHS4 inhibited the enhancer effect either when placed between the enhancer and the promoter or when placed upstream of the enhancer. These results suggest that the activity of cHS4 is not dominant in all contexts and is unlikely to prevent silencing at all genomic integration sites. PMID:10207095

  4. The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing.

    Science.gov (United States)

    Walters, M C; Fiering, S; Bouhassira, E E; Scalzo, D; Goeke, S; Magis, W; Garrick, D; Whitelaw, E; Martin, D I

    1999-05-01

    A constitutive DNase I-hypersensitive site 5' of the chicken beta-globin locus, termed 5'HS4 or cHS4, has been shown to insulate a promoter from the effect of an upstream enhancer and to reduce position effects on mini-white expression in Drosophila cells; on the basis of these findings, it has been designated a chromatin insulator. We have examined the effect of the cHS4 insulator in a system that assays both the level of gene expression and the rate of transcriptional silencing. Because transgenes flanked by insulator elements are shielded from position effects in Drosophila cells, we tested the ability of cHS4 to protect transgenes from position effects in mammalian cells. Flanking of an expression vector with the cHS4 insulator in a colony assay did not increase the number of G418-resistant colonies. Using lox/cre-based recombinase-mediated cassette exchange to control integration position, we studied the effect of cHS4 on the silencing of an integrated beta-geo reporter at three genomic sites in K562 erythroleukemia cells. In this assay, enhancers act to suppress silencing but do not increase expression levels. While cHS4 blocked enhancement at each integration site, the strength of the effect varied from site to site. Furthermore, at some sites, cHS4 inhibited the enhancer effect either when placed between the enhancer and the promoter or when placed upstream of the enhancer. These results suggest that the activity of cHS4 is not dominant in all contexts and is unlikely to prevent silencing at all genomic integration sites.

  5. Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites.

    Science.gov (United States)

    Bender, M A; Roach, J N; Halow, J; Close, J; Alami, R; Bouhassira, E E; Groudine, M; Fiering, S N

    2001-10-01

    The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the beta-globin LCR stimulates transcription of the linked beta-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive sites (5'HSs) that form in the nucleus of erythroid precursors. These HSs are conserved among mammals, bind transcription factors that also bind to other parts of the locus, and compose the functional components of the LCR. To test the hypothesis that individual HSs have unique properties, homologous recombination was used to construct 5 lines of mice with individual deletions of each of the 5'HSs of the endogenous murine beta-globin LCR. Here it is reported that deletion of 5'HS1 reduces expression of the linked genes by up to 24%, while deletion of 5'HS4 leads to reductions of up to 27%. These deletions do not perturb the normal stage-specific expression of genes from this multigenic locus. In conjunction with previous studies of deletions of the other HSs and studies of deletion of the entire LCR, it is concluded that (1) none of the 5'HSs is essential for nearly normal expression; (2) none of the HSs is required for proper developmental expression; and (3) the HSs do not appear to synergize either structurally or functionally, but rather form independently and appear to contribute additively to the overall expression from the locus.

  6. High sensitivity C - reactive protein (hs-CRP) and clinical characteristics, endocrine, metabolic profile in Indian women with PCOS: a correlation

    OpenAIRE

    Sunita Jaiprakash Ramanand; Jaiprakash B Ramanand; Girish T. Raparti; Ravi R Ghanghas; Nimish R. Halasawadekar; Praveenkumar T. Patil; Mayur P. Pawar; Mayur P. Shinde

    2014-01-01

    Background: Role of hs-CRP was studied in PCOS women. Methods: Correlation between serum hs-CRP and endocrine, metabolic profile was studied in 30 healthy women and 88 PCOS women. In PCOS women correlation between hs-CRP and clinical characteristics viz obesity, infertility, acne, hirsutism, acanthosis nigricans (AN) was also studied. Serum levels of hs-CRP, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH:FSH ratio, Testosterone (Testo), fasting insulin, fasting blood gluc...

  7. HS-AFP在肝癌早期诊断及鉴别诊断中的价值%The Value of HS-AFP in the Early Diagnosis and DifferentiaI Diagnosis of Hepatocellular Carcinoma

    Institute of Scientific and Technical Information of China (English)

    贲其稳; 倪润洲; 肖明兵; 陆翠华; 李立人; 毛振彪

    2008-01-01

    目的:探讨肝癌特异性甲胎蛋白(HS-AFP)对肝细胞癌的诊断及鉴别诊断价值.方法:对105例肝癌患者及151例良性肝病血清HS-AFP及AFP进行检测,并对10例HS-AFP阳性的良性肝病患者进行15个月随访观察.HS-AFP采用不连续缓冲系统PAGE结合Western blot分离检测,AFP采用化学发光法测定.结果:105例肝癌患者HS-AFP和AFP>200μg/L阳性率分别为60.0%和50.5%(P>0.05),良性肝痛患者HS-AFP阳性率显著低于AFP>200μg/L的阳性率(P<0.05).AFP处于50-400μg/L范围的肝癌组HS-AFP阳性率为77.1%.良性肝病组阳性率为13.6%(P<0.01).151例良性肝病中有10例HS-AFP出现阳性,其中3例于随访期间检出肝癌.11例小体积肝癌HS-AFP阳性率(45.5%)高于AFP>200μg/L的阳性率(18.2%).结论:HS-AFP对肝癌的诊断价值优于AFP浓度.对肝癌高危人群监测HS-AFP有助于肝癌的早期诊断.对血清AFP中低浓度升高的良恶性肝病有较高的鉴别诊断价值.

  8. NT-proBNP和hs-CRP在急性冠脉综合征诊断中的价值%The value of NT-proBNP and hs-CRP in acute coronary syndrome diagnosis

    Institute of Scientific and Technical Information of China (English)

    李茂

    2014-01-01

    Objective:To explore the levels of NT-proBNP and hs-CRP in serum of patients with acute coronary syndrome. Methods:50 cases of ACS were as the observation group;40 cases of healthy persons were as the control group.We detected the changes in the levels of NT-proBNP and hs-CRP in serum of the two groups.Results:In the observation group,the levels of NT-proBNP and hs-CRP in serum were significantly increased.Compared with the control group,the difference was statistically significant(P<0.05).Conclusion:The detection of NT-proBNP and hs-CRP is of great significance in the diagnosis of acute coronary syndrome.%目的:观察急性冠脉综合征(ACS)患者血清中NT-proBNP和hs-CRP水平。方法:50例ACS患者作观察组,40例健康者作对照组,检测两组血清中NT-proBNP和hs-CRP水平的变化。结果:观察组血清中NT-proBNP与hs-CRP水平均显著升高,与对照组相比差异有统计学意义(P<0.05)。结论:NT-proBNP和hs-CRP的检测对急性冠脉综合征的诊断具有重要意义。

  9. Increased hsCRP is associated with higher risk of aortic valve replacement in patients with aortic stenosis

    DEFF Research Database (Denmark)

    Blyme, Adam; Asferg, Camilla; Nielsen, O. W.

    2016-01-01

    Objective To investigate relations between inflammation and aortic valve stenosis (AS) by measuring high-sensitivity C-reactive protein, at baseline (hsCRP(0)) and after 1year (hsCRP(1)) and exploring associations with aortic valve replacement (AVR). Design We examined 1423 patients from...... the Simvastatin and Ezetimibe in Aortic Stenosis study. Results During first year of treatment, hsCRP was reduced both in patients later receiving AVR (2.3 [0.9-4.9] to 1.8 [0.8-5.4] mg/l, p...) predicted later AVR (HR=1.17, paortic valve area (AVA) and other risk factors. A higher rate of AVR was observed in the group with high hsCRP(0) and an increase during the first year (AVR(highCRP0CRP1inc)=47.3% versus AVR(highCRP0CRP1dec)=27.5%, p

  10. Reactions of superoxide dismutases with HS(-)/H2S and superoxide radical anion: An in vitro EPR study.

    Science.gov (United States)

    Bolić, Bojana; Mijušković, Ana; Popović-Bijelić, Ana; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Blagojević, Duško; Spasić, Mihajlo B; Spasojević, Ivan

    2015-12-01

    Interactions of hydrogen sulfide (HS(-)/H2S), a reducing signaling species, with superoxide dimutases (SOD) are poorly understood. We applied low-T EPR spectroscopy to examine the effects of HS(-)/H2S and superoxide radical anion O2.- on metallocenters of FeSOD, MnSOD, and CuZnSOD. HS(-)/H2S did not affect FeSOD, whereas active centers of MnSOD and CuZnSOD were open to this agent. Cu(2+) was reduced to Cu(1+), while manganese appears to be released from MnSOD active center. Untreated and O2.- treated FeSOD and MnSOD predominantly show 5 d-electron systems, i.e. Fe(3+) and Mn(2+). Our study provides new details on the mechanisms of (patho)physiological effects of HS(-)/H2S.

  11. Role of inflammation as reflected by serum hsCRP and ferritin level in major depressive disorder

    Directory of Open Access Journals (Sweden)

    Soma Gupta

    2016-09-01

    Conclusions: The significant change in hsCRP and Ferritin which is not associated with grade wise alteration suggests that probably inflammation is the early event which causes depression. Therefore no gradual change is observed with increase in severity of the disease. hsCRP can be used as a biomarker of Inflammation in MDD cases. [Int J Res Med Sci 2016; 4(9.000: 4072-4077

  12. High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men.

    Science.gov (United States)

    Lee, Jieun; Yoon, Kijung; Ryu, Seungho; Chang, Yoosoo; Kim, Hyoung-Ryoul

    2017-01-01

    We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (phs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development.

  13. High sensitive C-reactive protein (hs-CRP level and biochemical parameters for prehypertension and prediabetes diagnosis

    Directory of Open Access Journals (Sweden)

    Yuttana Sudjaroen

    2015-01-01

    Full Text Available Context: Coronary atherosclerosis still presents one of the main causes of death. Efficacious prevention should focus on the early control of cardiovascular risk factors, including lipid profiles, which are unable early detect in subclinical cases. High-sensitive C-reactive protein (hs-CRP can prove to be an early cardiac risk predictor. Aims: 1 To compare hs-CRP levels between healthy volunteer with normal blood pressure and those with prehypertension, and 2 to use hs-CRP levels along with other risks to be a cardiac risk predictor. Setting and Design: This was a cross-sectional study for 6 months′ duration from January to June 2013 at Kudjab Hospital located in Udon Thani province, Thailand. Materials and Methods: Forty (40 healthy volunteers with prehypertension and 40 volunteers with normal blood pressure were included in the study. Both groups were similar in age range and sex. Twelve-hour (12-h fasting blood samples were collected from all the participants. Serum was assayed for hs-CRP and lipid profile. Results: All of parameters were statistically significant difference (P < 000.1. The hs-CRP level (6.27 ± 7.8 mg/L was elevated in the prehypertension group. The relative risk of hs-CRP for prehypertension was 6.3 with the odds ratio of 15.48, whereas the relative risk of lipid profiles for prehypertension prediction was only 1.28, with the odds ratio of 1.67. Statistical Analysis: SPSS version 11.0 using the unpaired t-test for comparing demographic data and blood parameters and risk prediction of hs-CRP and lipid profiles were calculated by relative risk with odds ratio [95% confidence interval (CI]. Conclusions: Hs-CRP is an early cardiac risk predictor even with normal lipid profile, and can help measure additional risk especially subclinical people such as prehypertension.

  14. Determination of aromatic compounds in eluates of pyrolysis solid residues using HS-GC-MS and DLLME-GC-MS.

    Science.gov (United States)

    Bernardo, Maria S; Gonçalves, M; Lapa, N; Barbosa, R; Mendes, B; Pinto, F; Gulyurtlu, Ibrahim

    2009-11-15

    A method for the determination of 15 aromatic hydrocarbons in eluates from solid residues produced during the co-pyrolysis of plastics and pine biomass was developed. In a first step, several sampling techniques (headspace solid phase microextraction (HS-SPME), static headspace sampling (HS), and dispersive liquid-liquid microextraction (DLLME) were compared in order to evaluate their sensitivity towards these analytes. HS-SPME and HS sampling had the better performance, but DLLME was itself as a technique able to extract volatiles with a significant enrichment factor. HS sampling coupled with GC-MS was chosen for method validation for the analytes tested. Calibration curves were constructed for each analyte with correlation coefficients higher than 0.999. The limits of detection were in the range of 0.66-37.85 ng/L. The precision of the HS method was evaluated and good repeatability was achieved with relative standard deviations of 4.8-13.2%. The recoveries of the analytes were evaluated by analysing fortified real eluate samples and were in the range of 60.6-113.9%. The validated method was applied in real eluate samples. Benzene, toluene, ethylbenzene and xylenes (BTEX) were the compounds in higher concentrations. The DLLME technique coupled with GC-MS was used to investigate the presence of less volatile contaminants in eluate samples. This analysis revealed the presence of significant amounts of alkyl phenols and other aromatic compounds with appreciable water solubility.

  15. The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.

    Science.gov (United States)

    Liu, Li-Bin; Li, Mu; Zhuo, Wen-Yan; Zhang, Yu-Sheng; Xu, An-Ding

    2015-01-01

    The aim of this study was to evaluate the diagnostic value of the serum biochemical markers high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD) and fibrinogen (Fg) in differentiating etiological subtypes of ischemic stroke. This study was a retrospective case-only study, consecutively including patients with acute ischemic stroke. All patients were classified into subtypes using the TOAST classification system. A total of 317 patients were evaluated. Hs-CRP and DD levels were significantly different among the subtypes and were the highest in CE, followed by LAA and SAA; no significant difference between the subtypes was found for Fg. Hs-CRP > 6.96 mg/L was classified as the CE subtype, with a sensitivity of 41% and a specificity of 74%; DD > 791.30 ng/mL was classified as CE, with a sensitivity of 58% and a specificity of 78%. The combination of hs-CRP and DD classification as CE yielded a sensitivity of 65% and a specificity of 91%. DD > 791.30 ng/mL was considered an independent predictive factor of CE. Hs-CRP and DD could be useful for identifying the etiological subtypes of acute ischemic stroke, especially for predicting CE. The diagnostic value of DD was higher than that of hs-CRP.

  16. Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females.

    Science.gov (United States)

    Sanip, Zulkefli; Ariffin, Farah Diana; Al-Tahami, Belqes Abdullah Mohammed; Sulaiman, Wan Azman Wan; Rasool, Aida Hanum Ghulam

    2013-01-01

    Obese subjects had increased serum high sensitivity C-reactive protein (hs-CRP), decreased adiponectin levels, and impaired microvascular endothelial function compared to lean subjects. We investigated the relationships of serum hs-CRP, adiponectin and microvascular endothelial function with obesity indices and metabolic markers in overweight and obese female subjects. Anthropometric profile, body fat composition, biochemical analysis, serum hs-CRP and adiponectin levels, and microvascular endothelial function were measured in 91 female subjects. Microvascular endothelial function was determined using laser Doppler fluximetry and the process of iontophoresis. Mean age and body mass index (BMI) of subjects were 34.88 (7.87) years and 32.93 (4.82) kg/m(2). hs-CRP levels were positively correlated with weight, BMI, waist circumference, hip circumference, body fat and visceral fat. Adiponectin levels were positively correlated with insulin sensitivity index (HOMA-%S), and inversely correlated with waist hip ratio, triglyceride, fasting insulin and insulin resistance index (HOMA-IR). No relationship was seen between microvascular endothelial function and obesity indices, and metabolic markers. In overweight and obese female subjects, hs-CRP levels were correlated with obesity indices while adiponectin levels were inversely correlated with obesity indices and metabolic markers. No significant relationship was seen between microvascular endothelial function with obesity indices and metabolic markers including hs-CRP and adiponectin in female overweight and obese subjects.

  17. Elevated copper, hs C-reactive protein and dyslipidemia in drug free schizophrenia: Relation with psychopathology score.

    Science.gov (United States)

    Devanarayanan, Sivasankar; Nandeesha, Hanumanthappa; Kattimani, Shivanand; Sarkar, Siddharth; Jose, Jancy

    2016-12-01

    Inflammation, dyslipidemia and altered copper levels have been reported in several psychiatric disorders, including schizophrenia. However, their association with the severity of psychopathology in schizophrenia is yet to be established. The present study was designed to assess the serum levels of copper, highly sensitive C-reactive protein (hs-CRP) and lipid profile and to explore their association with psychopathology scores in schizophrenia. 40 cases and 40 controls were included in the study. Serum copper, hs-CRP and lipid profile were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS). Copper, hs-CRP, total cholesterol and LDL-Cholesterol were significantly increased and HDL-Cholesterol was significantly reduced in schizophrenia cases when compared with controls. Copper was positively correlated with hs-CRP (r=0.338, p=0.003). Total cholesterol was significantly correlated with PANSS total (r=0.452, p=0.003) and negative symptom scores (r=0.337, p=0.033). Triacylglycerol was positively correlated with general psychopathology symptom score (r=0.416, p=0.008). Copper and hs-CRP were increased and correlated well with each other in schizophrenia cases. Though total cholesterol and triacylglycerol showed positive association with severity of the psychopathology, copper and hs-CRP were not associated with the disease severity. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction

    Indian Academy of Sciences (India)

    Ke-Sheng Wang; Liang Wang; Xuefeng Liu; Min Zeng

    2013-12-01

    The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes. We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides). We examined genetic associations of 117 single-nucleotide polymorphisms (SNPs) within the HS6ST3 gene with obesity and triglycerides using two Caucasian samples: the Marshfield sample (1442 obesity cases and 2122 controls), and the Health aging and body composition (Health ABC) sample (305 cases and 1336 controls). Logistic regression analysis of obesity as a binary trait and linear regression analysis of triglycerides as a continuous trait, adjusted for age and sex, were performed using PLINK. Single marker analysis showed that six SNPs in the Marshfield sample and one SNP in the Health ABC sample were associated with obesity $(P \\lt 0.05)$. SNP rs535812 revealed a stronger association with obesity in meta-analysis of these two samples $(P = 0.0105)$. The T–A haplotype from rs878950 and rs9525149 revealed significant association with obesity in the Marshfield sample $(P = 0.012)$. Moreover, nine SNPs showed associations with triglycerides in the Marshfield sample $(P \\lt 0.05)$ and the best signal was rs1927796 $(P = 0.00858)$. In addition, rs7331762 showed a strong gene × gender interaction $(P = 0.00956)$ for obesity while rs1927796 showed a strong gene × gender interaction $(P = 0.000625)$ for triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.

  19. 佳能发布伊克萨斯IXUS 1000 HS

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    佳能IXU S1000 HS具有10倍光学变焦.但机身厚度仅约22.3毫米.在秉承伊克萨斯系列时尚设计风格的同时.实现了高倍光学变焦.IXU S1000 HS共有3种机身色彩可供选择,包括玛瑙褐,宝石粉和珍珠银.不但配置了“HS SYSTEM”.

  20. Tribological resistance of high speed steel HS 6-5-2 remelted with electric arc

    Directory of Open Access Journals (Sweden)

    A. Dziedzic

    2009-07-01

    Full Text Available The intensity of tribological wear of the high speed steel HS 6-5-2 remelted with the GTAW method has been compared to the heat treatment steel in a conventional way. Moreover, the types of the wear appeared during the friction. The tribiological research, were done in the technically dry friction conditions on a testing machine of the pin-on-disc T-01M. The smallest intensity of wear was shown by the high speed steel remelted with the parameters leading to obtain the biggest speed of cooling of the molten metal. The main wear type appearing during the research, was the abrasion and adhesive wear.

  1. Material characteristics of CLEARCERAM-Z HS for use in large diameter mirror blanks

    Science.gov (United States)

    Kishi, Takayuki; Goto, Naoyuki; Hoffman, Brion; Kawashima, Yasuyuki; Suzuki, Kenji; Yoshizawa, Kazuharu; Suzuki, Kaito

    2010-07-01

    There is growing interest within the Astronomical community in the development and use of very large aperture telescopes which will incorporate the latest advancements in optical materials. Two of the most notable of these large size telescope projects, the Thirty Meter Telescope (TMT) and European Extremely Large Telescope (E-ELT), will use mirror segments in the actively controlled primary mirrors. In this paper we present the results of a material characteristics study on Ohara CLEARCERAM®-Z HS large diameter blanks which includes data on the CTE, CTE uniformity, residual stress and internal quality targeting potential use in the TMT Primary Mirror Segment Banks.

  2. On the Source of Peace by Ahn Jung-geun%试析安重根和平思想之来源

    Institute of Scientific and Technical Information of China (English)

    韩英; 李艳梅

    2016-01-01

    东洋和平思想是近代东北亚各国思想家和政客们追求地域和平的最大话题之一,福泽谕吉、柳麟锡、康有为、孙中山等先后提出了或以日本为盟主,或以中国为盟主的不同主张。其中在哈尔滨刺杀侵略中国和韩国的元凶伊藤博文而闻名天下的韩国著名反日义士——安重根在旅顺日本人的监狱里提出的“东洋和平思想”独树一帜,展示了东北亚三国平等基础下建立区域和平共同体的伟大构想,给后人留下了无限的遐想。本文主要分析安重根在批判地接受儒家大同思想的基础上,形成了自己的和的天下观。%Peace is the key to pursuing regional safety peace by the ideologists inv the East and the statesman in modern Northeast Asia, FukuzawaYukichi, Liu Linxi, Kang Youwei, and Sun Yat-sen successively put forward opinions of taking Japan or China as the leader of an alliance. While Ahn Jung-geun, the famous Korean anti-Japanese hero who killed culprit Ito Hirobumi invading China and Korea in Harbin, proposed“Oriental thought of peace”in Lvshun Japanese prison was unique showing a great notion that the Northeast Asian countries es-tablish a regional peace community based on equality, and leaving much room for meditation for the coming generations. This paper analyzes how Ahn Jung-geun received Confucian cosmopolitism critically and formed his own view of the world.

  3. Study on the changes of RDW and hs-CRP in patients with preeclampsia%子痫前期患者 RDW 与 hs-CRP 检测的临床价值

    Institute of Scientific and Technical Information of China (English)

    王爱兰; 刘庆翠

    2015-01-01

    Objective:To evaluate the relationship of RDW and hs-CRP with the presence and severity of preeclampsia .Methods :RDW was meas-ured using blood cell counter ,and hs-CRP level of patients with preeclampsia was measured through ELISA method .Results:The RDW ,systolic and diastolic blood pressure ,proteinuria ,white blood cell and hs-CRP levels were significantly higher in preeclampsia group .Subgroup analysis revealed that RDW levels were significantly increased in patients with severe preeclampsia when compared to the patients with mild preeclampsia .Conclusion:The RDW and hs-CRP levels were significantly higher in preeclampsia group than control pregnancy patients ,and they increased with the increase of severity of disease ,the was a positive correlation between them .RDW can be used for indicator of severity of disease .%目的:评价红细胞分布宽度(RDW)及超敏C反应蛋白(hs -CRP)与子痫前期发病及严重程度的关系.方法:采用血细胞计数器测量 RDW值 ,酶联免疫吸附法(ELISA)测定子痫前期患者血清中CRP水平.结果:子痫前期组RDW、收缩压和舒张压、尿蛋白、白细胞和hs -CRP显著增高.亚组分析表明 ,重度子痫前期患者RDW水平较轻度组显著升高.结论:子痫前期患者RDW和hs-CRP明显高于正常妊娠者 ,且随着疾病严重程度的增加而升高 ,两者呈正相关.RDW可作为判断疾病轻重的指标.

  4. 功能化CdS∶Mn荧光探针测定hs-DNA%Detection of hs-DNA by functinal CdS∶Mn fluorescent probe

    Institute of Scientific and Technical Information of China (English)

    张艺; 李紫薇; 何晓燕; 王兴磊

    2015-01-01

    在油胺溶剂中,利用溶剂热法于160℃加热反应12 h,合成了CdS∶Mn量子点,并用巯基乙酸对合成的量子点进行了包裹.借助X射线衍射分析、傅里叶红外光谱、荧光谱图等测试方法对材料进行表征,数据表明,合成的CdS∶Mn量子点JCPDS#为80-0019,在CdS∶Mn量子点上成功修饰上了羧基(-COOH),CdS∶Mn晶体修饰前后主要发射峰从526 nm蓝移至488 nm.以COOH-CdS∶Mn功能化材料为荧光探针,基于DNA对材料的荧光猝灭,实现了对DNA的定量测定.实验在pH=6.6条件下,功能化荧光材料的荧光强度和鲱鱼精DNA(hs-DNA)的质量浓度呈线性关系,线性方程为△F =78.69-0.179c,检出限为0.053 mg/L,相关系数R=0.998 8,RSD =0.27%.

  5. Os tipos psicológicos na psicologia analítica de Carl Gustav Jung e o inventário de personalidade “Myers-Briggs Type Indicator (MBTI”: contribuições para a psicologia educacional, organizacional e clínica/The psychological types in analytical psychology of Carl Gustav Jung and the inventory of personality “Myers-Briggs Type Indicator (MBTI”: contributions for the educational, organizational and clinical psychology

    Directory of Open Access Journals (Sweden)

    Luís Marcelo Alves Ramos

    2005-01-01

    Full Text Available O texto apresenta os princípios da Teoria dos Tipos Psicológicos, a mais conhecida face da Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung (1875-1961, bem como os fundamentos do Inventário de Personalidade “Myers-Briggs Type Indicator (MBTI”, constituído a partir da tipologia junguiana, e que vem sendo cada vez mais utilizado nos campos da Psicologia Educacional, Organizacional e Clínica. The text presents the principles of the Theory of Psychological Types, the most known face of the Analytical Psychology of the Swiss psychologist and psychiatrist Carl Gustav Jung (1875-1961, as well as the fundamentals of the Inventory of Personality “Myers-Briggs Type Indicator (MBTI”, constituted from the Jungian typology, and which has been more used nowadays by Educational, Organizational and Clinical Psychology.

  6. Effects of fluorinated and hydrogenated surfactants on human serum albumin at different pHs.

    Science.gov (United States)

    Sabín, Juan; Prieto, Gerardo; González-Pérez, Alfredo; Ruso, Juan M; Sarmiento, Félix

    2006-01-01

    Complexation between human serum albumin (HSA) and two different surfactants, one fully fluorinated (sodium perfluorooctanoate, SPFO) and one fully hydrogenated (sodium caprylate, SO), was studied using zeta-potential measurements and difference spectroscopy. The study was carried out at three different pHs, 3.2, 6.7, and 10.0. The spectroscopy study was performed at pHs 6.7 and 10.0, given that at pH 3.2 high turbidity was observed in the wide range of surfactant concentrations. The results were interpreted in terms of the electrostatic and hydrophobic contributions to the stability of the different phases formed in the water-surfactant-HSA system. Solutions and precipitates were observed in the concentration range investigated in more detail. Using Pace methods, the thermodynamic values of the surfactant-induced conformational changes in HSA were determined for sodium perfluorooctanoate in the concentration range 2-12 mmol dm(-3) at pH 6.7 and 5-22 mmol dm(-3) at pH 10.0. Electrophoretic measurements were used to characterize surfactant adsorption by determining the number of molecules adsorbed on the surface of HSA and the Gibbs energy of adsorption. Finally, the interactions between human serum albumin and other anionic surfactants studied by other authors were compared with those observed in the present work.

  7. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000.

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    Rune Brautaset

    Full Text Available Optical coherence tomography (OCT, can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance.Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. Repeatability was evaluated by use of the coefficient of repeatability (CR and the coefficient of repeatability as a percentage of the mean (CR%, and the obtained measurements were compared between the instruments.CR% of optic disc parameters ranged between 0.90 and 22.22% and 0.00 and 16.00% with the Canon and Zeiss OCT respectively. For macular parameters CR% ranged between 0.62 and 2.81% and 0.99 and 1.81% with the Canon and Zeiss OCT respectively. No statistical difference could be found when comparing the CR of all macular and disc measurements between the instruments. Compared to our previously published data repeatability has significantly improved with the inclusion of automatic tracking systems with both the Canon and Zeiss OCT.Automatic tracking function improves repeatability in both Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. However, measurements generated by the two instruments are still not interchangeable.

  8. Comparison of continuous and discontinuous counterimmunoelectrophoresis with immunodiffusion in identification of candida antibody using HS antigen.

    Science.gov (United States)

    Marier, R; Andriole, V T

    1978-07-01

    We have compared continuous counterimmunoelectrophoresis (CCIE) and discontinuous counterimmunoelectrophoresis (DCIE) with immunodiffusion (ID) in the identification of Candida albicans antibody using HS antigen. Eighteen sera with a titer of 1/1 to 1/32 1/32 by CCIE were titered by CCIE and ID. Fewer were positive by CCIE and ID (13 of 18 and 9 of 18, respectively). Furthermore, the titers were lower when measured by these two methods in comparison to DCIE (4 of 18 and 3 of 18 sera had titers greather than or equal to 1/8 in comparison with 7 of 18 greater than or equal to 1/8 by DCIE). Finally, DCIE was found to be much faster than CCIE and ID. After 20 min of electrophoresis, 17 of 21 sera were positive by DCIE, whereas none were positive by CCIE. Even after 90 min, only 10 of 21 were positive by CCIE, whereas 4 of 21 were positive by ID. The increased sensitivity and speed of DCIE over CCIE and ID suggest that DCIE is preferable to these other methods in the measurement of candida antibody using HS antigen.

  9. 联合检测Hcy、Cysc及hs-CRP对妊娠期高血压疾病的意义%The significance of joint detection of Hcy, CysC and hs-CRP for the diagnosis of HDP

    Institute of Scientific and Technical Information of China (English)

    王挺; 连炬飞; 周永贤; 郭莉; 陈汉彪

    2014-01-01

    Objective To evaluate the clinical value of serum homocysteine (Hcy),cystalin C (CysC) and high-sensitivity C-reactive protein (hs-CRP) joint detect for the diagnosis of hypertensive disorders complicating pregnancy (HDP).Method Serum levels of Hcy,CysC and hs-CRP of 86 HDP patients (HDP group) and 96 normal pregnant women (control group) were measured,analyzed and compared.Results Comparing HDP group and control group,severe HDP group and mild HDP group,there were significances differences in serum levels of Hcy,CysC and hs-CRP(P<0.05).Significant positive correlation exist between Hcy and Cysc,hs-CRP in HDP group (r=0.592,0.668),and the serum levels of Hcy,CysC and hs-CRP is positively correlated with the severity of HDP(r=0.759,0.266,0.365).Conclusion The serum levels of Hcy,CysC and hs-CRP in HDP patient is positively correlated with the severity of HDP.Joint detection of the serum levels of Hcy,CysC and hs-CRP is important for the diagnosis of HDP and illness progression and prognosis.%目的 探讨血清同型半胱氨酸(Hcy)、胱抑素C(CysC)及超敏-C反应蛋白(hs-CRP)联合检测对诊断妊娠期高血压疾病(HDP)的临床价值.方法 选取86例妊娠期高血压疾病患者(HDP组)和96例正常妊娠孕妇(对照组),分别检测血清Hcy 、CysC和hs-CRP,并对结果进行分析比较.结果 HDP组与对照组比较,重度HDP组与轻度HDP组比较,Hcy、CysC和hs-CRP差异均有统计学意义(P<0.05).HDP组Hcy与CysC、hs-CRP呈显著正相关(r=0.592、0.668),且Hcy 、CysC和hs-CRP浓度与HDP病情轻重呈正相关(r=0.759、0.266、0.365).结论 HDP患者血清Hcy 、Cysc和hs-CRP浓度与HDP病情轻重呈正相关,联合检测对诊断妊娠期高血压疾病及其病情进展、预后判断具有重要的指导意义.

  10. hs-CRP与2型糖尿病伴有高血压的关系%High plasmid hs-CRP level in patients with DM2 and HBP Daqing Oilfield General Hospital Laboratory Medicine

    Institute of Scientific and Technical Information of China (English)

    张丽娜; 车璐; 曹艳菲; 李新娜; 崔颖; 寇筱囡; 陈刚

    2013-01-01

    Objective We study if plasma levels of hs-CRP related to DM2+HBP patients. Methods hs-CRP were measured in subjects with DM2 and /or HBP, including 13 patients with DM2, 17 patients with HBP, 34 patients with DM2+HBP, and 25 healthy test control subjects. hs-CRP tested by Electro-Chemiluminescence Immuno Assay (ECLI). Results The plasma hs-CRP levels were significantly lower in the controls than in the DM2+HBP group (p<0.05), DM2 associated with HBP was also correlated with increased plasma hs-CRP levels (n=89, r =0.25, p=0.0160). Conclusions This study suggests that patients with two associated diseases have a more active inflammatory state.%目的:研究炎性反应标志物超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)与2型糖尿病(type 2 diabetes mel itus, DM2)伴随或者不伴随高血压是否存在相关性。方法入组13例2型糖尿病患者无合并症,17例高血压患者(high blood pressure, HBP),34例2型糖尿病伴随高血压患者(DM2+HBP),25例健康体检对照组,电化学免疫发光法测定血清hs-CRP。结果健康对照组hs-CRP水平明显低于HBP+DM2患者(p<0.05),DM2伴随HBP与hs-CRP水平显著相关(n=89, r=0.25, p=0.0160)。讨论 DM2+HBP患者具有相对活跃的炎性状态。

  11. Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain

    Directory of Open Access Journals (Sweden)

    Seggelen Vera

    2005-02-01

    Full Text Available Abstract Background In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1 although their functions differ considerable. In this manuscript we describe the genomic organization of these two genes in a variety of species by a combination of cloning and database searches. Based on our analysis, we predict the genesis of the actin-binding repeat domain during evolution. Results Cortactin homologues exist in sponges, worms, shrimps, insects, urochordates, fishes, amphibians, birds and mammalians, whereas HS1 exists in vertebrates only, suggesting that both genes have been derived from an ancestor cortactin gene by duplication. In agreement with this, comparative genome analysis revealed very similar exon-intron structures and sequence homologies, especially over the regions that encode the characteristic highly conserved F-actin-binding repeat domain. Cortactin splice variants affecting this F-actin-binding domain were identified not only in mammalians, but also in amphibians, fishes and birds. In mammalians, cortactin is ubiquitously expressed except in hematopoietic cells, whereas HS1 is mainly expressed in hematopoietic cells. In accordance with their distinct tissue specificity, the putative promoter region of cortactin is different from HS1. Conclusions Comparative analysis of the genomic organization and amino acid sequences of cortactin and HS1 provides inside into their origin and evolution. Our analysis shows that both genes originated from a gene duplication event and subsequently HS1 lost two repeats, whereas cortactin gained one repeat. Our analysis genetically underscores the significance of the F-actin binding domain in

  12. h-FABP、hs-CRP、cTnT对急性心肌梗死诊断临床价值分析%Clinical Value of h - FABP, hs - CRP, cTnT examination to diagnose acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    张翠玲; 姜艳梅; 高霞; 王欣

    2008-01-01

    [目的]通过对h-FABP、hs-CRP、cTnT 3项指标的联合检测为急性心肌梗死(AMI)的诊断提供可靠依据.[方法]cTnT检测采用金标记免疫渗滤法;hs-CRP检测采用免疫散射比浊法;h-FABP检测采用96T ELISA方法.[结果]健康组与AMI组比较,h-FABP:(5.46±0.19),(23.27±1.77)ng/mL,P<0.01;cTnT:(0.10±0.01),(0.64±0.11)ng/mL,P<0.01;hs-CRP:(0.85±0.10),(17.39±4.69)mg/L,P<0.01;cTnT、hs-CRP、h-FABP在40例AMI患者发作0~3 h阳性率分别为50%、55.26%、85%.3项指标联合分析阳性率可达98%.[结论]h-FABP、hs-CRP与cTnT联合检测对AMI早期诊断具有高灵敏性和特异性.

  13. Bion and C.G. Jung. How did the container-contained model find its thinker? The fate of a cryptomnesia.

    Science.gov (United States)

    Maier, Christian

    2016-04-01

    This paper investigates the possible impact of C.G. Jung's Tavistock Lectures on Bion's concept of the living container. In the first part of the paper, the author offers clues pointing to such an essential impact, which can be found in text passages as well as in the facts of the Bion-Beckett case, up to and including Bion's first publication of 'The imaginary twin'. The author suggests that cryptomnesia is the result of repression targeting a highly cathected author's communication which functions like a deep interpretation for the recipient, whose new theory then is a return of the repressed content as well as a transformation of it. The second part of the paper investigates the fate of the assumed cryptomnesia. From this point of view Bion's concept of the container in itself appears to be the result of growth in the container-contained mode. Finally the author deals with the question whether cryptomnesia in psychoanalytical literature can frequently be seen as the result of psychic growth.

  14. The Charm of Psychoanalytic Aesthetics--A Glimpse to Jung' s Aesthetics%精神分析美学的魅力--容格美学掠影

    Institute of Scientific and Technical Information of China (English)

    赵士林

    2005-01-01

    @@ 一、容格美学思想的心理学基础 作为一位心理学家,容格(Carl Gustav Jung,1875-1961)的美学思想完全衍生于他的心理学理论,是他运用心理学理论分析神话乃至文学艺术的成果;容格的美学思想又是容格心理学理论的重要支柱,因为他的重要的心理学贡献往往从美学分析与艺术分析入手.因此,要了解容格的美学思想,需先了解他的与之相关的心理学理论,而了解容格的美学思想又是了解容格心理学的不可或缺的途径.

  15. Precedent fluctuation of serum hs-CRP to albumin ratios and mortality risk of clinically stable hemodialysis patients.

    Directory of Open Access Journals (Sweden)

    Jyh-Chang Hwang

    Full Text Available A high sensitivity C-reactive protein to albumin ratio (hs-CRP/Alb predicts mortality risk in patients with acute kidney injury. However, it varies dynamically. This study was conducted to evaluate whether a variation of this marker was associated with long-term outcome in clinically stable hemodialysis (HD patients.hs-CRP/Alb was checked bimonthly in 284 clinically stable HD outpatients throughout all of 2008. Based on the "slope" of trend equation derived from 5-6 hs-CRP/alb ratios for each patient, the total number of patients was divided into quartiles--Group 1: β≦ -0.13, n = 71; group 2: β>-0.13≦0.003; n = 71, group 3: β>0.003≦0.20; and group 4: β>0.20, n = 71. The observation period was from January 1, 2009 to August 31, 2012.Group 1+4 showed a worse long-term survival (p = 0.04 and a longer 5-year hospitalization stay than Group 2+3 (38.7±44.4 vs. 16.7±22.4 days, p<0.001. Group 1+4 were associated with older age (OR = 1.03, 95% CI = 1.01-1.05 and a high prevalence of congestive heart failure (OR = 2.02, 95% CI = 1.00-4.11. Standard deviation (SD of hs-CRP/Alb was associated with male sex (β = 0.17, p = 0.003, higher Davies co-morbidity score (β = 0.16, p = 0.03, and baseline hs-CRP (β = 0.39, p<0.001. Patients with lower baseline and stable trend of hs-CRP/Alb had a better prognosis. By multivariate Cox proportional methods, SD of hs-CRP/alb (HR: 1.05, 95% CI: 1.01-1.08 rather than baseline hs-CRP/Alb was an independent predictive factor for long-term mortality after adjusting for sex and HD vintage.Clinically stable HD patients with a fluctuating variation of hs-CRP/Alb are characterized by old age, and more co-morbidity, and they tend to have longer subsequent hospitalization stay and higher mortality risk.

  16. A Site-Specific Integrative Plasmid Found in Pseudomonas aeruginosa Clinical Isolate HS87 along with A Plasmid Carrying an Aminoglycoside-Resistant Gene.

    Directory of Open Access Journals (Sweden)

    Dexi Bi

    Full Text Available Plasmids play critical roles in bacterial fitness and evolution of Pseudomonas aeruginosa. Here two plasmids found in a drug-resistant P. aeruginosa clinical isolate HS87 were completely sequenced. The pHS87b plasmid (11.2 kb carries phage-related genes and function-unknown genes. Notably, pHS87b encodes an integrase and has an adjacent tRNAThr-associated attachment site. A corresponding integrated form of pHS87b at the tRNAThr locus was identified on the chromosome of P. aeruginosa, showing that pHS87b is able to site-specifically integrate into the 3'-end of the tRNAThr gene. The pHS87a plasmid (26.8 kb displays a plastic structure containing a putative replication module, stability factors and a variable region. The RepA of pHS87a shows significant similarity to the replication proteins of pPT23A-family plasmids. pHS87a carries a transposon Tn6049, a truncated insertion sequence ΔIS1071 and a Tn402-like class 1 integron which contains an aacA4 cassette that may confer aminoglycoside resistance. Thus, pHS87b is a site-specific integrative plasmid whereas pHS87a is a plastic antibiotic resistance plasmid. The two native plasmids may promote the fitness and evolution of P. aeruginosa.

  17. NaHS Protects Cochlear Hair Cells from Gentamicin-Induced Ototoxicity by Inhibiting the Mitochondrial Apoptosis Pathway.

    Directory of Open Access Journals (Sweden)

    Yaodong Dong

    Full Text Available Aminoglycoside antibiotics such as gentamicin could cause ototoxicity in mammalians, by inducing oxidative stress and apoptosis in sensory hair cells of the cochlea. Sodium hydrosulfide (NaHS is reported to alleviate oxidative stress and apoptosis, but its role in protecting aminoglycoside-induced hearing loss is unclear. In this study, we investigated the anti-oxidant and anti-apoptosis effect of NaHS in in vitro cultured House Ear Institute-Organ of Corti 1 (HEI-OC1 cells and isolated mouse cochlea. Results from cultured HEI-OC1 cells and cochlea consistently indicated that NaHS exhibited protective effects from gentamicin-induced ototoxicity, evident by maintained cell viability, hair cell number and cochlear morphology, reduced reactive oxygen species production and mitochondrial depolarization, as well as apoptosis activation of the intrinsic pathway. Moreover, in the isolated cochlear culture, NaHS was also demonstrated to protect the explant from gentamicin-induced mechanotransduction loss. Our study using multiple in vitro models revealed for the first time, the potential of NaHS as a therapeutic agent in protecting against aminoglycoside-induced hearing loss.

  18. NaHS Protects Cochlear Hair Cells from Gentamicin-Induced Ototoxicity by Inhibiting the Mitochondrial Apoptosis Pathway

    Science.gov (United States)

    Dong, Yaodong; Liu, Dongliang; Hu, Yue; Ma, Xiulan

    2015-01-01

    Aminoglycoside antibiotics such as gentamicin could cause ototoxicity in mammalians, by inducing oxidative stress and apoptosis in sensory hair cells of the cochlea. Sodium hydrosulfide (NaHS) is reported to alleviate oxidative stress and apoptosis, but its role in protecting aminoglycoside-induced hearing loss is unclear. In this study, we investigated the anti-oxidant and anti-apoptosis effect of NaHS in in vitro cultured House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and isolated mouse cochlea. Results from cultured HEI-OC1 cells and cochlea consistently indicated that NaHS exhibited protective effects from gentamicin-induced ototoxicity, evident by maintained cell viability, hair cell number and cochlear morphology, reduced reactive oxygen species production and mitochondrial depolarization, as well as apoptosis activation of the intrinsic pathway. Moreover, in the isolated cochlear culture, NaHS was also demonstrated to protect the explant from gentamicin-induced mechanotransduction loss. Our study using multiple in vitro models revealed for the first time, the potential of NaHS as a therapeutic agent in protecting against aminoglycoside-induced hearing loss. PMID:26295804

  19. A3-Coupling catalyzed by robust Au nanoparticles covalently bonded to HS-functionalized cellulose nanocrystalline films

    Directory of Open Access Journals (Sweden)

    Jian-Lin Huang

    2013-07-01

    Full Text Available We decorated HS-functionalized cellulose nanocrystallite (CNC films with monodisperse Au nanoparticles (AuNPs to form a novel nanocomposite catalyst AuNPs@HS-CNC. The uniform, fine AuNPs were made by the reduction of HAuCl4 solution with thiol (HS- group-functionalized CNC films. The AuNPs@HS-CNC nanocomposites were examined by X-ray photoelectron spectroscopy (XPS, TEM, ATR-IR and solid-state NMR. Characterizations suggested that the size of the AuNPs was about 2–3 nm and they were evenly distributed onto the surface of CNC films. Furthermore, the unique nanocomposite Au@HS-CNC catalyst displayed high catalytic efficiency in promoting three-component coupling of an aldehyde, an alkyne, and an amine (A3-coupling either in water or without solvent. Most importantly, the catalyst could be used repetitively more than 11 times without significant deactivation. Our strategy also promotes the use of naturally renewable cellulose to prepare reusable nanocomposite catalysts for organic synthesis.

  20. Effect of sludge retention time and phosphorus to carbon ratio on biological phosphorus removal in HS-SBR process.

    Science.gov (United States)

    Zhu, Rui; Wu, Min; Yang, Jian

    2013-01-01

    Sludge retention time (SRT) and phosphorus to carbon ratio (P/C) in the feed are important control parameters in biological phosphorus removal. In this study, humus soil sequencing batch reactor (HS-SBR) process was operated with different SRTs (five, 10 and 15 days) and P/C feeding (0.0125 and 0.1) to evaluate their phosphorus removal efficiencies. The HS-SBR was composed of a humus soil reactor (HSR) and a conventional SBR (designated as hsSBR to differentiate from the conventional SBR used as a control). The results showed that the phosphorus removal efficiency was 82.7%, 97.3% and 97.3% at SRTs of five, 10 and 15 days respectively and acetate utilization efficiency for phosphorus release with SRTs of 10 and 15 days was much higher than that with an SRT of five days. In addition, a high P/C feeding (0.1) could promote the growth of the phosphate accumulating organisms in the hsSBR; however, the efficiency of phosphorus removal was lower than a low P/C feeding (0.0125) at an SRT of 15 days. All these observations suggested that a relatively long SRT and low P/C feeding exert a useful effect on the phosphorus removal in the hsSBR.

  1. THE IMPLICATION OF PERIODONTITIS TO ATHEROSCLEROSIS: ITS RELATIONSHIP WITH LIPID PROFILE AND hs-CRP SERUM CONCENTRATION

    Directory of Open Access Journals (Sweden)

    Rasmidar Samad

    2015-06-01

    Full Text Available C-Reactive Protein and serum lipids are correlated with atherosclerosis. The purpose of this study was to prove that increasing level of hs-CRP and serum lipids were correlated with periodontitis. This was a cross-sectional approach with 63 samples. Periodontitis was determined if the pocket depth (PD was more than 4 mm and the attachment loss (AL was more than 2 mm. Serum lipids and hs-CRP was analyzed by enzymatic method and chemiluminescent (Immulite hs_CRP alternatively. With unpaired t-test it has showed that there was a difference level of hs-CRP and total cholesterol in periodontitis and non-periodontitis. It was found that there was a significant positive correlation between PD (r=0.26, AL (r=0.25 with hs-CRP serum level; and PD (r=0.27, AL (r=0.30 with total cholesterol and LDL. It was concluded that there is a possibility that there is a relationship between periodontitis and atherosclerosis.

  2. NaHS Protects against the Impairments Induced by Oxygen-Glucose Deprivation in Different Ages of Primary Hippocampal Neurons

    Science.gov (United States)

    Yu, Qian; Wang, Binrong; Zhao, Tianzhi; Zhang, Xiangnan; Tao, Lei; Shi, Jinshan; Sun, Xude; Ding, Qian

    2017-01-01

    Brain ischemia leads to poor oxygen supply, and is one of the leading causes of brain damage and/or death. Neuroprotective agents are thus in great need for treatment purpose. Using both young and aged primary cultured hippocampal neurons as in vitro models, we investigated the effect of sodium hydrosulfide (NaHS), an exogenous donor of hydrogen sulfide, on oxygen-glucose deprivation (OGD) damaged neurons that mimick focal cerebral ischemia/reperfusion (I/R) induced brain injury. NaHS treatment (250 μM) protected both young and aged hippocampal neurons, as indicated by restoring number of primary dendrites by 43.9 and 68.7%, number of dendritic end tips by 59.8 and 101.1%, neurite length by 36.8 and 66.7%, and spine density by 38.0 and 58.5% in the OGD-damaged young and aged neurons, respectively. NaHS treatment inhibited growth-associated protein 43 downregulation, oxidative stress in both young and aged hippocampal neurons following OGD damage. Further studies revealed that NaHS treatment could restore ERK1/2 activation, which was inhibited by OGD-induced protein phosphatase 2 (PP2A) upregulation. Our results demonstrated that NaHS has potent protective effects against neuron injury induced by OGD in both young and aged hippocampal neurons.

  3. A3-Coupling catalyzed by robust Au nanoparticles covalently bonded to HS-functionalized cellulose nanocrystalline films

    Science.gov (United States)

    Huang, Jian-Lin

    2013-01-01

    Summary We decorated HS-functionalized cellulose nanocrystallite (CNC) films with monodisperse Au nanoparticles (AuNPs) to form a novel nanocomposite catalyst AuNPs@HS-CNC. The uniform, fine AuNPs were made by the reduction of HAuCl4 solution with thiol (HS-) group-functionalized CNC films. The AuNPs@HS-CNC nanocomposites were examined by X-ray photoelectron spectroscopy (XPS), TEM, ATR-IR and solid-state NMR. Characterizations suggested that the size of the AuNPs was about 2–3 nm and they were evenly distributed onto the surface of CNC films. Furthermore, the unique nanocomposite Au@HS-CNC catalyst displayed high catalytic efficiency in promoting three-component coupling of an aldehyde, an alkyne, and an amine (A3-coupling) either in water or without solvent. Most importantly, the catalyst could be used repetitively more than 11 times without significant deactivation. Our strategy also promotes the use of naturally renewable cellulose to prepare reusable nanocomposite catalysts for organic synthesis. PMID:23946833

  4. Correlation of gene polymorphism and plasma contents of MBL and hs-CRP in patients with coronary heart disease%冠心病与MBL基因多态性及血浆MBL和hs-CRP水平的相关性

    Institute of Scientific and Technical Information of China (English)

    蔡念光; 王玉凤; 王晓明; 程健君; 贾天军; 吕占军

    2011-01-01

    Objective To analyze the correlation between coronary heart disease(CHD) and the gene polymorphism of mannan binding lectin(MBL), the plasma contents of MBL and the level of high-sensitivity C-reactive protein (hs-CRP).Methods The anti-coagulated blood of CHD patients (group CHD, 100 cases) and healthy people(group C,60 cases) was collected.The point mutation of MBL ExonI 54 codon was detected by PCR-RFLP.The content of MBL and the level of hs-CRP were detected by ELISA kit and immunoturbidimetry, respectively.Results There was no significant difference in the genotypes of MBL ExonI 54 codon between group CHD and group C(P>0.05).The plasma content of MBL and the level of hs-CRP in group CHD were higher than those in group C (P<0.01).In group CHD, there was no obvious difference in the content of MBL between the patients with high level of hs-CRP(>3 mg/L) and those with normal level of hs-CRP(<3 mg/L) (P>0.05).Conclusion MBL and hs-CRP may be involved in the occurrence and development of CHD via different mechanisms.%目的 研究冠心病(CHD)与甘露聚糖结合凝集素(MBL)基因多态性及其血浆MBL和高敏G-反应蛋白(hs-CRP)水平的关系.方法 收集100例CHD患者(CHD组)和60例健康人群(对照组)抗凝血,限制片段长度多态性法(PCR-RFLP)检测MBL ExonI 54位密码子基因点突变,ELISA法和免疫比浊法分别检测血浆MBL含量和高敏G-反应蛋白(hs-CRP)水平.结果 CHD组与对照组MBL基因ExonI 54位密码子点突变频率比较差异无统计学意义(P>0.05).CHD组血浆MBI和hs-CRP含量均高于对照组(P<0.01).而CHI组内血浆hs-CRP水平升高者(>3 mg/L)与hs-CRP水平正常者(<3 mg/L)MBL含量比较差异无统计学意义(P>0.05).结论 MBL和hs-CRP可能以不同机制参与CHD发生、发展过程.

  5. RoHS directive: restriction of the use of lead in electronic equipment

    CERN Multimedia

    2007-01-01

    The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here. Please note that the session will be held in French.

  6. RoHS directive: restriction of the use of lead in electronic equipment

    CERN Multimedia

    2007-01-01

    The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 to p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here Please note that the session will be held in French.

  7. Danish WEEE management in the light of the WEEE and RoHS Directives: a quantitative analysis of critical issues

    DEFF Research Database (Denmark)

    Pizzol, Massimo; Thomsen, Marianne

    Waste from Electrical and Electronic Equipment (WEEE) is the fastest growing waste fraction in Europe and is classified as hazardous as it may include substances that have adverse effects on human health or cause damage to the environment (UNEP, 2009). The European Community Directive 2002/96/EC...... on Waste Electrical and Electronic Equipment (WEEE Directive), together with the European Community Directive 2002/95/EC on the Restriction of Hazardous Substances (RoHS Directive) were established respectively to set collection, recycling and recovery targets, and to restrict the use of six hazardous......HS directive, flows of toxic compounds are still significant in WEEE, as can be demonstrated by performing a Substance Flow Analysis (SFA) (Brunner, 2004) on a Danish WEEE treatment facility. This is due to the presence, in the WEEE, of devices constituting an exception to the RoHS directive and of other...

  8. RoHS regulated substances in mixed plastics from waste electrical and electronic equipment.

    Science.gov (United States)

    Wäger, Patrick A; Schluep, Mathias; Müller, Esther; Gloor, Rolf

    2012-01-17

    The disposal and recovery of plastics from waste electrical and electronic equipment (WEEE) are of considerable importance, both from an environmental and an economic perspective. This paper presents the results of a study investigating current concentrations of hazardous substances in mixed plastics from WEEE and their implications for an environmentally sound recovery. The study included 53 sampling campaigns for mixed plastics from WEEE. The samples were analyzed with regard to heavy metals (cadmium, chromium, mercury, and lead) and flame retardants (PentaBDE, OctaBDE, DecaBDE, DecaBB) regulated in the RoHS Directive. Besides these substances, other brominated flame retardants known to occur in electronics (HBCD, TBBPA) as well as the total bromine and phosphorus contents were considered. Results show that no mixed plastics fraction from WEEE is completely free from substances regulated in the RoHS Directive. The lowest number and average concentrations were found in flat screen monitors. The highest concentrations were found in mixed plastics from CRT monitors and TVs. Mixed plastics fractions with high average concentrations of heavy metals originate from the treatment of small household appliances (cadmium), ICT equipment (lead), and consumer equipment (lead). Mixed plastics fractions with high average concentrations of brominated flame retardants mainly originate from the treatment of small household appliances for high temperature applications (DecaBDE), CRT monitors (OctaBDE and DecaBDE) and consumer equipment (DecaBDE), in particular CRT TVs (DecaBDE). To avoid a dissipation of hazardous substances into plastics and the environment, it is recommended that mixed plastics from WEEE are subject to a strict quality management.

  9. Revealing fibrinogen monolayer conformations at different pHs: electrokinetic and colloid deposition studies.

    Science.gov (United States)

    Nattich-Rak, Małgorzata; Adamczyk, Zbigniew; Wasilewska, Monika; Sadowska, Marta

    2015-07-01

    Adsorption mechanism of human fibrinogen on mica at different pHs is studied using the streaming potential and colloid deposition measurements. The fibrinogen monolayers are produced by a controlled adsorption under diffusion transport at pH of 3.5 and 7.4. Initially, the electrokinetic properties of these monolayers and their stability for various ionic strength are determined. It is shown that at pH 3.5 fibrinogen adsorbs irreversibly on mica for ionic strength range of 4×10(-4) to 0.15 M. At pH 7.4, a partial desorption is observed for ionic strength below 10(-2) M. This is attributed to the desorption of the end-on oriented molecules whereas the side-on adsorbed molecules remain irreversibly bound at all ionic strengths. The orientation of molecules and monolayer structure is evaluated by the colloid deposition measurements involving negatively charged polystyrene latex microspheres, 820 nm in diameter. An anomalous deposition of negative latex particles on substrates exhibiting a negative zeta potential is observed. At pH 3.5 measurable deposition of latex is observed even at low ionic strength where the approach distance of latex particles exceeded 70 nm. At pH 7.4 this critical distance is 23 nm. This confirms that fibrinogen monolayers formed at both pHs are characterized by the presence of the side-on and end-on oriented molecules that prevail at higher coverage range. It is also shown that positive charge is located at the end parts of the αA chains of the adsorbed fibrinogen molecules. Therefore, it is concluded that the colloid deposition method is an efficient tool for revealing protein adsorption mechanisms at solid/electrolyte interfaces.

  10. Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.

    Science.gov (United States)

    Guerrieri, Elena; Mallareddy, Jayapal Reddy; Tóth, Géza; Schmidhammer, Helmut; Spetea, Mariana

    2015-03-18

    Herein we report the radiolabeling and pharmacological investigation of a novel radioligand, the N-cyclobutylmethyl substituted diphenethylamine [(3)H]HS665, designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders). HS665 was prepared in tritium-labeled form by a dehalotritiated method resulting in a specific activity of 30.65 Ci/mmol. Radioligand binding studies were performed to establish binding properties of [(3)H]HS665 to the recombinant human KOP receptor in membranes from Chinese hamster ovary cells stably expressing human KOP receptors (CHOhKOP) and to the native neuronal KOP receptor in guinea pig brain membranes. Binding of [(3)H]HS665 was specific and saturable in both tissue preparations. A single population of high affinity binding sites was labeled by [(3)H]HS665 in membranes from CHOhKOP cells and guinea pig brain with similar equilibrium dissociation constants, Kd, 0.45 and 0.64 nM, respectively. Average receptor density of [(3)H]HS665 recognition sites were 5564 and 154 fmol/mg protein in CHOhKOP cells and guinea pig brain, respectively. This study shows that the new radioligand distinguishes and labels KOP receptors specifically in neuronal and cellular systems expressing KOP receptors, making this molecule a valuable tool in probing structural and functional mechanisms governing ligand-KOP receptor interactions in both a recombinant and native in vitro setting.

  11. The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.

    Directory of Open Access Journals (Sweden)

    Nynne Sharma

    Full Text Available DNA transposons have become important vectors for efficient non-viral integration of transgenes into genomic DNA. The Sleeping Beauty (SB, piggyBac (PB, and Tol2 transposable elements have distinct biological properties and currently represent the most promising transposon systems for animal transgenesis and gene therapy. A potential obstacle, however, for persistent function of integrating vectors is transcriptional repression of the element and its genetic cargo. In this study we analyze the insulating effect of the 1.2-kb 5'-HS4 chicken β-globin (cHS4 insulator element in the context of SB, PB, and Tol2 transposon vectors. By examining transgene expression from genomically inserted transposon vectors encoding a marker gene driven by a silencing-prone promoter, we detect variable levels of transcriptional silencing for the three transposon systems in retinal pigment epithelium cells. Notably, the PB system seems less vulnerable to silencing. Incorporation of cHS4 insulator sequences into the transposon vectors results in 2.2-fold and 1.5-fold increased transgene expression levels for insulated SB and PB vectors, respectively, but an improved persistency of expression was not obtained for insulated transgenes. Colony formation assays and quantitative excision assays unveil enhanced SB transposition efficiencies by the inclusion of the cHS4 element, resulting in a significant increase in the stable transfection rate for insulated SB transposon vectors in human cell lines. Our findings reveal a positive impact of cHS4 insulator inclusion for SB and PB vectors in terms of increased transgene expression levels and improved SB stable transfection rates, but also the lack of a long-term protective effect of the cHS4 insulator against progressive transgene silencing in retinal pigment epithelium cells.

  12. Relationship of serum levels of hs-CRP and Hcy with gestational diabetes mellitus and pregnancy outcomes%血清hs-CRP、Hcy与妊娠期糖尿病及妊娠结局的关系

    Institute of Scientific and Technical Information of China (English)

    徐旭赟; 黄美英

    2015-01-01

    Objective To evaluate the value of combined detection of high sensitivity C-reactive protein ( hs-CRP ) and homocysteine (Hcy) levels in diagnosing gestational diabetes mellitus (GDM) and its value on predicting pregnancy outcomes. Methods Thirty-five women with GDM accepting pre-natal screening in Third People’ s Hospital of Anji County from January 2012 to March 2014 were selected in observation group. Another 35 healthy women diagnosed without GDM at the same period were selected in control group. The levels of hs-CRP, Hcy, fasting plasma glucose ( FPG) and fasting insulin ( FINS) in two groups were detected and compared, and the pregnancy outcomes were followed up. Results The levels of FPG, FINS, hs-CRP and Hcy in the observation group were higher than those in the control group, and the differences were significant (t value was 13. 07, 12. 02, 3. 65 and 12. 02, respectively, all P <0. 05). The incidence of adverse reactions was 34. 3% (12/35) and 11. 4% (4/35) in the observation group and the control group, respectively with statistical significance (χ2 =5. 19,P<0. 05). Sixteen cases were found with adverse pregnancy outcomes, and their hs-CRP and Hcy levels were higher than those of 54 normal pregnant women (t value was 7. 88 and 14. 17, respectively, both P<0. 05). Conclusion The levels of hs-CRP and Hcy are closely related with GDM, and the high levels have predictive value for adverse pregnancy outcomes. Therefore, attention should be attracted on them.%目的:探讨联合检测超敏C反应蛋白( hs-CRP)和同型半胱氨酸( Hcy)水平在妊娠期糖尿病( GDM)诊断及对妊娠结局的预测价值。方法选择2012年1月至2014年3月在安吉县第三人民医院门诊接受检查的GDM患者35例作为观察组;选择同期经临床排除GDM的正常孕产妇35例作为对照组。检测两组患者的hs-CRP和Hcy、空腹血糖和胰岛素水平,并跟踪两组妊娠结局。结果观察组患者空腹血糖、胰岛素、hs-CRP 和 Hcy

  13. 冠心病血清 hs_CRP、ox_LDL及 Hcy 水平的研究%Study of Levels of Serum hs CRP,ox LDL and Hcy in Patients with Coronary Heart Disease

    Institute of Scientific and Technical Information of China (English)

    李方江; 王晓元; 张文婷; 杜美玲; 李清; 张强; 李慧敏

    2015-01-01

    目的:探讨冠心病患者外周血高敏C反应蛋白(hs CRP )、氧化型低密度脂蛋白(ox LDL )和同型半胱氨酸(Hcy )水平及其意义。方法选取经冠状动脉造影检查证实冠心病组272例,分为急性心肌梗死(AMI )组105例,不稳定型心绞痛(UA )组126例,稳定型心绞痛(SAP )组41例;选取冠状动脉造影证实冠状动脉无狭窄病变56例为对照组。采集研究对象入院24小时内静脉血,ELISA法检测ox LDL水平,日立7070型全自动生化分析仪测定hs CRP、Hcy、总胆固醇(TC )、甘油三脂(TG )、低密度脂蛋白(LDL )指标。结果冠心病组血清hs CRP、ox LDL、Hcy水平显著高于对照组,差异有统计学意义( P<0.01);AMI组血清hs CRP、ox LDL、Hcy水平显著高于SAP组,差异有统计学意义( P<0.05);AMI组血清hs CRP、ox LDL水平显著高于UA组,差异有统计学意义( P<0.05)。结论联合检测hs CRP、ox LDL、Hcy有助于对冠心病的诊断。%Objective To investigate the level and significance of peripheral high sensitivity C reactive protein (hs CRP ) ,oxidized low density lipoprotein (ox LDL ) and homocysteine (Hcy ) in patients with coronary heart disease. Methods 272 patients with coro-nary heart disease were selected ,which confirmed by coronary angiography , including 105 cases of acute myocardial infarction (AMI) ,126 cases of unstable angina (UA) and 41 cases of stable angina patients (SAP). The control group included 56 patients with no coronary artery stenosis confirmed by coronary angiography . Collected the fasting blood of patients within 24 hours of admis-sion ,the levels of ox LDL was detected by ELISA ,and the determination of hs CRP、Hcy、total cholesterol ,triglycerides ,LDL index was detected by Hitachi 7070 automatic biochemical analyzer. Results The serum levels of hs CRP、ox LDL、Hcy in the grope of coro-nary heart disease were significantly higher than

  14. Redox chemistry of H[sub 2]S oxidation by the British Gas Stretford Process. Pt. 2; Electrochemical behaviour of aqueous hydrosulphide (HS[sup -]) solutions

    Energy Technology Data Exchange (ETDEWEB)

    Kelsall, G.H.; Thompson, I. (Imperial College, London (United Kingdom). Dept. of Mineral Resources Engineering)

    1993-04-01

    Electrochemical techniques were used to study the oxidation of HS[sup -] ions at pH 9.3. Voltammetry of gold electrodes in HS[sup -]-containing solutions showed that multilayers of sulphur and soluble oxidation products were formed. As a known HS[sup -] oxidation product, thiosulphate solutions were also studied voltammetrically, but found to be electro-inactive at mildly oxidising potentials. The voltammetric behaviour of polysulphide ions, S[sub n][sup 2-] (n = 2 to 5), was similar to that of HS[sup -] solutions on oxidation, though they could be reduced to HS[sup -] ions at low potentials. Ring-disc electrode experiments, extending the HS[sup -] concentration range that had been studied previously, confirmed that polysulphide ions were produced on reduction of anodically deposited elemental sulphur. This was demonstrated in both cyclic voltammetry and potential step experiments. (author)

  15. HS-SPME-GC-MS分析螺旋藻挥发性成分%Analysis of Volatile Components of Spirulina by HS-SPME-GC-MS

    Institute of Scientific and Technical Information of China (English)

    张丽君; 许柏球; 王金林; 罗欢忠; 陈晚霞; 林伟强

    2013-01-01

      The Spirulina platensis was selected as material and the odor flavor components was analyzed .The volatile components was determined by Headspace solid phase microextraction combined with gas hromatography mass spectrometry (HS-SPME-GC-MS).The results showd that 17 volatile components were indentified,including alkanes (relative content 79.77%), aldehydes and ketones (relative content 18.27%), alcohols (relative content 0.84 %) and aromatic compounds (relative content 1.17 %). The main volatile components of Spirulina platensis were Heptadecane (relative content 64.52 %), Pentadecane ( relative content8.59%), Dihydroactinidiolide (relative content 7.21%) ,β-ionone ( relative content 6.65%) and Hexadecane (relative content4.29%).%  以钝顶螺旋藻藻粉为原料,对其腥味物质进行分析。采用顶空固相微萃取和气相色谱-质谱联用技术,对钝顶螺旋藻的挥发性成分进行检测,共鉴定出17种有机化合物,烷烃类化合物(相对含量79.77%)、醛酮类化合物(相对含量18.27%)、醇类化合物(相对含量0.84%)、芳香族化合物(相对含量1.17%)。螺旋藻的主要挥发成分依次为十七烷(平均相对含量为64.52%)、十五烷(平均相对含量为8.59%)、二氢猕猴桃内酯(平均相对含量为7.21%)、β-紫罗兰酮(平均相对含量为6.65%)和十六烷(平均相对含量为4.29%)。

  16. Effect of autoclave heat treatments on the mechanical properties of the prealloyed powder cobalt-base alloy HS-31

    Science.gov (United States)

    Freche, J. C.; Ashbrook, R. L.

    1973-01-01

    The cobalt-base alloy HS-31 was atomized into powder and then consolidated by extrusion or by hot isostatic pressing (HIP) in an autoclave over a range of temperatures spanning the solidus, approximately 2340 F. Extrusions were subsequently autoclaved at the same conditions. Extrusions autoclaved at 2420 F had a life of 300 hours at 1200 F and 30 hours at 1800 F at stresses that result in a 10-hour life with cast HS-31. Superior stress rupture lives of autoclaved material are probably related to the solidification structure at the grain boundaries as well as to the increased grain size.

  17. Galectin 1 Proangiogenic and Promigratory Effects in the Hs683 Oligodendroglioma Model Are Partly Mediated through the Control of BEX2 Expression

    OpenAIRE

    Mercier, Marie Le; Fortin, Shannon; Mathieu, Véronique; Roland, Isabelle; Spiegl-Kreinecker, Sabine; Haibe-Kains, Benjamin; Bontempi, Gianluca; Decaestecker, Christine; Berger, Walter; Lefranc, Florence; Kiss, Robert

    2009-01-01

    We have previously reported that galectin 1 (Gal-1) plays important biological roles in astroglial as well as in oligodendroglial cancer cells. As an oligodendroglioma model, we make use of the Hs683 cell line that has been previously extensively characterized at cell biology, molecular biology, and genetic levels. Galectin 1 has been shown to be involved in Hs683 oligodendroglioma chemoresistance, neoangiogenesis, and migration. Down-regulating Gal-1 expression in Hs683 cells through targete...

  18. What Do Very Low Plasma Concentrations of High-sensitivity C-reactive Protein (hs-CRP) Mean among Healthy Middle-aged Koreans?

    OpenAIRE

    Kim, Min-Gul; Cho, Baik-Hwan; Chae, Soo-Wan; Park, Tae-Sun; Kim, Dal-Sik

    2015-01-01

    Background Systemic low-grade inflammation (SLGI), as assessed by measurements of high-sensitivity C-reactive protein (hs-CRP), is a strong independent risk factor for cardiovascular diseases (CVD). Although individuals with hs-CRP ≤ 1 mg/L have been defined as being at low risk according to AHA/CDC guidelines, the value of very low hs-CRP levels (

  19. 5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.

    Directory of Open Access Journals (Sweden)

    Ping Kei Chan

    Full Text Available Hypersensitive site 5 (5'HS5 of the beta-globin Locus Control Region functions as a developmental stage-specific border in erythroid cells. Here, we have analyzed the role of 5'HS5 in the three dimensional organization of the beta-gene locus using the Chromatin Conformation Capture (3C technique. The results show that when 5'HS5 is deleted from the locus, both remote and internal regulatory elements are still able to interact with each other in a three-dimensional configuration termed the Active Chromatin Hub. Thus, the absence of 5'HS5 does not have an appreciable effect on the three dimensional organization of the beta-globin locus. This rules out models in which 5'HS5 nucleates interactions with remote and/or internal regulatory elements. We also determined the binding of CTCF, the only defined insulator protein in mammalian cells, to 5'HS5 by using chromatin immunoprecipitation (ChIP assays. We detect low levels of CTCF binding to 5'HS5 in primitive erythroid cells, in which it functions as a border element. Surprisingly, we also observe binding levels of CTCF to 5'HS5 in definitive erythroid cells. Thus, binding of CTCF to 5'HS5 per se does not render it a functional border element. This is consistent with the previous data suggesting that CTCF has dual functionality.

  20. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.

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    Wai Kit Chan

    Full Text Available Heparan sulfate (HS is a linear carbohydrate composed of polymerized uronate-glucosamine disaccharide units that decorates cell surface and secreted glycoproteins in the extracellular matrix. In mammals HS is subjected to differential sulfation by fifteen different heparan sulfotransferase (HST enzymes of which Hs2st uniquely catalyzes the sulfation of the 2-O position of the uronate in HS. HS sulfation is postulated to be important for regulation of signaling pathways by facilitating the interaction of HS with signaling proteins including those of the Fibroblast Growth Factor (Fgf family which signal through phosphorylation of extracellular signal-regulated kinases Erk1/2. In the developing mouse telencephalon Fgf2 signaling regulates proliferation and neurogenesis. Loss of Hs2st function phenocopies the thinned cerebral cortex of mutant mice in which Fgf2 or Erk1/2 function are abrogated, suggesting the hypothesis that 2-O-sulfated HS structures play a specific role in Fgf2/Erk signaling pathway in this context in vivo. This study investigated the molecular role of 2-O sulfation in Fgf2/Erk signaling in the developing telencephalic midline midway through mouse embryogenesis at E12.5. We examined the expression of Hs2st, Fgf2, and Erk1/2 activity in wild-type and Hs2st-/- mice. We found that Hs2st is expressed at high levels at the midline correlating with high levels of Erk1/2 activation and Erk1/2 activation was drastically reduced in the Hs2st-/- mutant at the rostral telencephalic midline. We also found that 2-O sulfation is specifically required for the binding of Fgf2 protein to Fgfr1, its major cell-surface receptor at the rostral telencephalic midline. We conclude that 2-O sulfated HS structures generated by Hs2st are needed to form productive signaling complexes between HS, Fgf2 and Fgfr1 that activate Erk1/2 at the midline. Overall, our data suggest the interesting possibility that differential expression of Hs2st targets the rostral

  1. BIOTECHNOLOGICAL APPROACHES FOR CONSERVATION OF THE ENDANGERED SPECIES Crambe koktebelica (JUNGE N. BUSCH AND EFFECT OF ASEPTIC IN VITRO CULTIVATION ON ITS BIOCHEMICAL PROPERTIES

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    Pushkarova

    2016-08-01

    Full Text Available The aim of the study was to establish efficient protocols of seed surface sterilization with further multiplication in vitro for threatened species Crambe koktebelica (Junge N. Busch and to show the effect of biotechnological approach (in vitro cultivation of biodiversity conservation on plants biochemical properties. Seed surface sterilization was carried out according to the original method with further microclonal multiplication of aseptic sprouts from lateral buds on the Murashige and Skoog (MS medium supplemented with different concentrations of growth regulators. Fatty acid content was determined using Gas chromatography-mass spectrophotometry of fatty acid ethers. Antioxidant activity was determined using 2.2-diphenyl-1-picrylhydrazyl radical scavenging method. Total soluble protein content was measured using Bradford method and polyfructan content determination was based upon ketosugars ability to color in the acidic environment with resorcinol. Plants that were grown under in vitro and in vivo conditions and seeds were used in this research. Efficient protocol of surface sterilization that resulted in 45% of aseptic seed material 50% of which has sprouted was elaborated for C. koktebelica as well as fast microclonal multiplication methods that provided with up to 5.25 ± 0.50 new formed plantlets from 1 lateral bud (on the MS medium that contained 1 mg/L of 6-benzylaminopurine. It was also shown that aseptic cultivation benefits to saturated fatty acid accumulation and increases protein content but on the other hand it reduces unsaturated fatty acid amount and polyfructan content as well as antioxidant activity of plant material. Obtained data confirms the prospect of biotechnology approach to biodiversity conservation and suggest the necessity of father in vitro cultivation effect on biochemical composition of plant study.

  2. LDL-C和hs-CRP在急性冠脉综合征诊断中的价值%Diagnosis value of LDL-C and hs-CRP in acute coronary syndrome

    Institute of Scientific and Technical Information of China (English)

    叶碧宁

    2012-01-01

    目的 分析研究低密度脂蛋白胆固醇(LDL-C)、血清高敏C 反应蛋白(hs-CRP)对急性冠脉综合征(ACS)的临床诊断价值.方法 选择2009年9月至2010年9月期间该院心内科收治的84例ACS患者作为研究组,并选择同时期门诊体检的84例健康者作为对照组,分别用免疫比浊法检测两组的血清hs-CRP水平,速率法检测LDL-C水平,并分析计算LDL-C和hs-CRP在诊断ACS方面的效能.结果 研究组血清LDL-C和hs-CRP的浓度明显高于对照组的(P<0.05).单独LDL-C诊断ACS的敏感性与特异性分别为51.2%和82.3%,阳性和阴性预测值分别为75.9%和55.3%.单独hs-CRP诊断ACS的敏感性与特异性分别为48.8%和85.6%,阳性和阴性预测值分别为73.8%和52.9%.LDL-C和hs-CRP联合诊断ACS的阳性例数为82例,与单独LDL-C诊断的阳性例数差异有显著性(χ2=6.41,P<0.05),与单独hs-CRP诊断的阳性例数也差异有显著性(χ2=6.63,P<0.05),敏感性与特异性分别为95.6%和46.3%,阳性和阴性预测值分别为65.6%和91.2%.结论 联合检测LDL-C和hs-CRP可有助于早期诊断ACS.%Objective To explore detection value of low-density lipoprotein cholesterol( LDL-C ) and high sensitive C-reactive protein ( hs-CRP ) in the diagnosis of acute coronary syndrome( ACS ). Methods Eighty-four cases of ACS as the research group were collected and 84 healthy people as the control group were collected. Serum hs-CRP levels of the two groups were tested by immune turbidimetry method, and LDL-C levels were tested by rate method. Efficiency of hs-CRP level and LDL-C level in the diagnosis of ACS was analyzed. Results The levels of LDL-C and hs-CRP of the research group were significantly higher than those in the control group, with P <0. 05. The sensitivity and specificity of LDL-C in the diagnosis of ACS was 51. 2% and 82. 3% , positive and negative predictive value was 75. 9% and 55. 3% . The sensitivity and specificity of hs-CRP in the diagnosis of ACS was 48. 8% and 85

  3. Levels and prognostic significance of NT-ProBNP,hs-CRP in chronic heart failure%慢性心力衰竭NT-ProBNP、hs-CRP变化及其预后价值

    Institute of Scientific and Technical Information of China (English)

    周金锋; 程自平

    2013-01-01

    目的 探讨B型钠尿肽前体(NT-ProBNP)和高敏C反应蛋白(hs-CRP)联合检测对心力衰竭诊断、病情评估和预后判断的价值.方法 测定该院2010年1月-2012年11月103例明确诊断为充血性心力衰竭(CHF)的患者,测定入院时、出院时血浆NT-ProBNP 和血清hs-CRP水平,进行治疗前后对比观察,并随机抽取该院35名健康体检者作对照组比较,随访6月观察患者心脏事件再发生的情况.结果 血浆NT-ProBNP和血清hs-CRP和水平在心衰不同心功能分级组和健康对照组之间差异有统计学意义,心功能越差,其浓度越高(P<0.05);治疗前后比较,差异均也有统计学意义(P<0.05);出院后发生心脏事件组血浆NT-ProBNP 和血清hs-CRP水平浓度明显高于未发生心脏事件组(P<0.05).结论 心衰患者中NT-ProBNP 、hs-CRP明显升高,二者联合检测对心衰诊断、病情评估和预后判断有应用意义.%Objective To observe the value of B-type natriuretic peptide precursor (NT -ProBNP)and high-sensitivity C-eactive protein (hs-CRP)on patients of heart failure in diagnosis , illness evaluation and prognosis through jointed detection . Methods From January 2010 to November 2012,103 cases of CHF patients were measured plasma NT -ProBNP and hs -CRP serum levels on admission and at discharge. Before and after treatment comparison observations were made ,35 health were selected randomly for control. The patients were followed up for 6 months to observe it cardiac events happen again . Results NT-ProBNP and hs -CRP serum and plasma levels in different heart failure cardiac function grading group had statistically significant difference from healthy control group . The poorer heart function , the higher concentration ( P < 0.05 ) ; Before and after treatment, difference had statistical significance ( P < 0.05 ) ; Concentrations of plasma NT -ProBNP and hs -CRP level were significantly higher in cardiac evento after discharge group than those without cardiac

  4. hs-CRP与肥胖青少年心血管疾病发生风险的相关性研究%hs-CRP level was associated to diagnosis of cardiovascular risk in obese teenagers

    Institute of Scientific and Technical Information of China (English)

    张丽娜; 寇筱囡; 李新娜; 曹艳菲; 车璐

    2014-01-01

    目的:探讨超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)作为肥胖青少年心血管疾病发病风险的生物标志物的评估价值。方法6-18岁青少年,体重指数(body mass index, BMI)超过2 SDS。所有入组对象空腹12h采集静脉血,检测hs-CRP,肝脏功能检测,血脂检测,尿酸等检测;糖耐量试验。我们认为肥胖青少年存在代谢综合征症状,至少包括两个以下症状:高甘油三酯血症、低高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)、高血压及糖代谢障碍。结果115例青少年患者中,24%显示存在代谢综合症,存在代谢综合症的患者血清hs-CRP水平(M=3.8ml/L;95% CI:2.9-4.8)高与不存在代谢综合征症状的肥胖青少年(M=1.9ml/L;95% CI:1.5-2.5),经多变量分析,影响hs-CRP水平的是BMI、甘油三酯、HDL-C水平。讨论血清hs-CRP是判断肥胖青少年是否存在早期心血管疾病发生风险的有价值的生物标志物。%Objective To assess the utility of the high -sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese teenagers. Methods The study included teenagers between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. Al the patients had their blood pressure taken and hs-CRP, hepatic function, lipid and uric acid were determined after 12 h of fasting, likewise , an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. Results Out of the 115 obese teenagers 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (M=3.8ml/L; 95% CI: 2.9-4.8) in comparison with the obese patients who did not show signs of metabolic syndrome(M=1.9ml/L; 95% CI: 1.5-2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-C levels. Conclusions The hs-CRP is

  5. Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening.

    Science.gov (United States)

    Ma, Yi; Ghoshdastider, Umesh; Wang, Jufang; Ye, Wei; Dötsch, Volker; Filipek, Slawomir; Bernhard, Frank; Wang, Xiaoning

    2012-12-01

    Glucosamine 6-phosphate N-acetyltransferase (GNA1; EC 2.3.1.4) is required for the de novo synthesis of N-acetyl-d-glucosamine-6-phosphate (GlcNAc-6P), which is an essential precursor in Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) biosynthesis pathway. Therefore, GNA1 is indispensable for the viability of organisms. Here, a novel cell-free expression strategy was developed to efficiently produce large amounts of human GNA1(HsGNA1) and HsGNA1-sGFP for throughput inhibitor screening. The binding site of inhibitor glucose-6-phosphate (G6P) to hGNA was identified by simulated annealing. Subtle differences to the binding site of Aspergillius GNA1(AfGNA1) can be harnessed for inhibitor design. HsGNA1 may be also useful as an antimicrobial and chemotherapeutic target against cancer. Additionally HsGNA1 inhibitors/modulators can possibly be administered with other drugs in the next generation of personalized medicine.

  6. Heat Perception and Aversive Learning in Honey Bees: Putative Involvement of the Thermal/Chemical Sensor AmHsTRPA.

    Science.gov (United States)

    Junca, Pierre; Sandoz, Jean-Christophe

    2015-01-01

    The recent development of the olfactory conditioning of the sting extension response (SER) has provided new insights into the mechanisms of aversive learning in honeybees. Until now, very little information has been gained concerning US detection and perception. In the initial version of SER conditioning, bees learned to associate an odor CS with an electric shock US. Recently, we proposed a modified version of SER conditioning, in which thermal stimulation with a heated probe is used as US. This procedure has the advantage of allowing topical US applications virtually everywhere on the honeybee body. In this study, we made use of this possibility and mapped thermal responsiveness on the honeybee body, by measuring workers' SER after applying heat on 41 different structures. We then show that bees can learn the CS-US association even when the heat US is applied on body structures that are not prominent sensory organs, here the vertex (back of the head) and the ventral abdomen. Next, we used a neuropharmalogical approach to evaluate the potential role of a recently described Transient Receptor Potential (TRP) channel, HsTRPA, on peripheral heat detection by bees. First, we applied HsTRPA activators to assess if such activation is sufficient for triggering SER. Second, we injected HsTRPA inhibitors to ask whether interfering with this TRP channel affects SER triggered by heat. These experiments suggest that HsTRPA may be involved in heat detection by bees, and represent a potential peripheral detection system in thermal SER conditioning.

  7. Time delay in the variability of multiply lensed QSOs HS0810+2554 and Q2237+030

    Science.gov (United States)

    Storrs, Alex; Lainez, Sergio

    2017-01-01

    We present time delay in variability between the brightest lensed images of two multiply lensed QSO systems, HS0810+2554 and Q2237+030. This data can help constrain the mass distribution of the lensing galaxies, and perhaps on Hubble’s Constant as well. Observations were made with the Towson University 0.4m telescope.

  8. Complete genomic sequence of Campylobacter jejuni subsp. jejuni HS:19 strain RM1285 that was isolated from packaged chicken

    Science.gov (United States)

    Poultry products serve as the main source of Campylobacter jejuni subsp. jejuni (Cjj) infections in humans. Cjj infections are a leading cause of foodborne gastroenteritis and are a prevalent antecedent to Guillain-Barré syndrome (GBS). This study describes the genome of Cjj HS:19 strain RM1285 isol...

  9. Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−/− Mice

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    Asha Ford

    2013-01-01

    Full Text Available Hydrogen sulfide is emerging as an important mediator of vascular function that has antioxidant and cytoprotective effects. The aim of this study was to investigate the role of endogenous H2S and the effect of chronic exogenous H2S treatment on vascular function during the progression of atherosclerotic disease. ApoE−/− mice were fed a high-fat diet for 16 weeks and treated with the H2S donor NaHS or the cystathionine-γ-lyase (CSE inhibitor D,L-propargylglycine (PPG, to inhibit endogenous H2S production for the final 4 weeks. Fat-fed ApoE−/− mice displayed significant aortic atherosclerotic lesions and significantly impaired endothelial function compared to wild-type mice. Importantly, 4 weeks of NaHS treatment significantly reduced vascular dysfunction and inhibited vascular superoxide generation. NaHS treatment significantly reduced the area of aortic atherosclerotic lesions and attenuated systolic blood pressure. Interestingly, inhibiting endogenous, CSE-dependent H2S production with PPG did not exacerbate the deleterious vascular changes seen in the untreated fat-fed ApoE−/− mice. The results indicate NaHS can improve vascular function by reducing vascular superoxide generation and impairing atherosclerotic lesion development. Endogenous H2S production via CSE is insufficient to counter the atherogenic effects seen in this model; however exogenous H2S treatment has a significant vasoprotective effect.

  10. Development of a Direct Headspace Collection Method from Arabidopsis Seedlings Using HS-SPME-GC-TOF-MS Analysis

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    Kazuki Saito

    2013-04-01

    Full Text Available Plants produce various volatile organic compounds (VOCs, which are thought to be a crucial factor in their interactions with harmful insects, plants and animals. Composition of VOCs may differ when plants are grown under different nutrient conditions, i.e., macronutrient-deficient conditions. However, in plants, relationships between macronutrient assimilation and VOC composition remain unclear. In order to identify the kinds of VOCs that can be emitted when plants are grown under various environmental conditions, we established a conventional method for VOC profiling in Arabidopsis thaliana (Arabidopsis involving headspace-solid-phase microextraction-gas chromatography-time-of-flight-mass spectrometry (HS-SPME-GC-TOF-MS. We grew Arabidopsis seedlings in an HS vial to directly perform HS analysis. To maximize the analytical performance of VOCs, we optimized the extraction method and the analytical conditions of HP-SPME-GC-TOF-MS. Using the optimized method, we conducted VOC profiling of Arabidopsis seedlings, which were grown under two different nutrition conditions, nutrition-rich and nutrition-deficient conditions. The VOC profiles clearly showed a distinct pattern with respect to each condition. This study suggests that HS-SPME-GC-TOF-MS analysis has immense potential to detect changes in the levels of VOCs in not only Arabidopsis, but other plants grown under various environmental conditions.

  11. Do albuminuria and hs-CRP add to the International Diabetes Federation definition of the metabolic syndrome in predicting outcome?

    NARCIS (Netherlands)

    van der Velde, Marije; Bello, Aminu K.; Brantsma, Auke H.; El Nahas, Meguid; Bakker, Stephan J. L.; de Jong, Paul E.; Gansevoort, Ronald T.

    2012-01-01

    Background. To investigate the added value of elevated urinary albumin excretion (UAE) and high high-sensitive C-reactive protein (hs-CRP) in predicting new-onset type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) and chronic kidney disease (CKD) in addition to the present metabolic syndr

  12. Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

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    Waode Nurfina

    2010-12-01

    Full Text Available BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS and correlate with the inflammation and oxidative stress. METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP and F2-Isoprostane. RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220 and F2-Isoprostane (r=0.023. CONCLUSIONS: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane. KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane.

  13. Study to evaluate serum free testosterone and hsCRP concentration to predict low hematocrit in type 2 diabetes mellitus

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    Radhey Shyam Chejara

    2015-06-01

    Conclusion: At the end of the study we concluded that both a low serum free testosterone level and high hs-CRP concentration may play an important role in the pathogenesis of mild anemia and low hematocrit values in DM type 2 patients. [Int J Res Med Sci 2015; 3(6.000: 1501-1504

  14. A new naphthalenepropanoic acid analog from the marine-derived actinomycetes Micromonospora sp. HS-HM-036.

    Science.gov (United States)

    Gao, Mei-Yue; Qi, Huan; Li, Jian-Song; Zhang, Hui; Zhang, Ji; Wang, Ji-Dong; Xiang, Wen-Sheng

    2017-09-01

    A new naphthalenepropanoic acid analog (1) was isolated from the broth of the actinomycetes Micromonospora sp. HS-HM-036. The structure of compound 1 was determined based on MS and extensive NMR analysis. A preliminary investigation of the biological activity of compound 1 was also described.

  15. The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.

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    Annarita Miccio

    Full Text Available Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the HS2 enhancer of the GATA1 gene in protecting the expression of a β-globin minigene delivered by a lentiviral vector in hematopoietic stem/progenitor cells. Gene expression from proviruses carrying GATA1-HS2 in both LTRs was persistent and resistant to silencing at most integration sites in the in vivo progeny of human hematopoietic progenitors and murine long-term repopulating stem cells. The GATA1-HS2-modified vector allowed correction of murine β-thalassemia at low copy number without inducing clonal selection of erythroblastic progenitors. Chromatin immunoprecipitation studies showed that GATA1 and the CBP acetyltransferase bind to GATA1-HS2, significantly increasing CBP-specific histone acetylations at the LTRs and β-globin promoter. Recruitment of CBP by the LTRs thus establishes an open chromatin domain encompassing the entire provirus, and increases the therapeutic efficacy of β-globin gene transfer by reducing expression variegation and epigenetic silencing.

  16. HS-SPME/GC-MS分析发酵人参香气成分%Analysis of Volatile Components of Fermented Panax Ginseng by HS-SPME/GC-MS

    Institute of Scientific and Technical Information of China (English)

    柴贺; 周亚楠; 初琦; 王玉华; 朴春红

    2016-01-01

    研究Kefir粒发酵对人参香气成分产生的影响.鲜人参经预处理后进行Kefir粒无氧和有氧发酵,利用顶空固相微萃取与气质联用相结合的方法优化顶空萃取头类型、萃取时间、萃取温度,再分析发酵前后人参香气成分的变化.结果表明:萃取头类型为非键合型PDMS(聚二甲基硅氧烷,涂层厚度100μm)、萃取时间为30 min,萃取温度为75℃时萃取效果最佳.该条件下未发酵人参香气共50种,其中烷烃类21种,萜烯类18种,醇类4种,醛酮类2种,酚类2种,芳香类1种,含氮杂环化合物2种,人参呈土腥味;Kefir粒无氧发酵人参香气成分共64种,其中烷烃类22种,萜烯类21种,醇类9种,醛酮类4种,芳香类3种,酯类2种,酚类1种,含氮杂环化合物2种,发酵后的人参呈果香和朗姆味;Kefir粒有氧发酵人参香气成分共64种,其中烷烃19种,萜烯类22种,醇类8种,醛酮类4种,芳香类2种,酯类3种,酚酸类2种,含氮杂环化合物4种,发酵后的人参呈草药味和烧烤香味.Kefir发酵人参显著提高了人参的芳香气味.%In order to study on the effect of Kefir fermented ginseng on the aroma components of panax ginseng, headspace solid-phase microextraction (HS-SPME) and gas chromatograph coupled with mass spectrometry (GC-MS) were used for the qualitative determination of volatile components in ginseng, anaerobic fermented ginseng and aerobic fermented ginseng. The conditions of SPME fiber type, extraction time and equilibrium temperature were optimized. Optimum adsorption was achieved using PDMS (100μm) fiber for adsorption at 75 ℃for 30 min. As a result, 50 aroma compounds were extracted out of the ginseng, including 21 alkanes, 18 terpenes, 4 alcohols, 2 aldehydes and ketones, 2 phenols, 1 aromatics, 2 heterocyclic.Samples were smelled of wood and earth; 64 aroma compounds were extracted out of the anaerobic ginseng, including 22 alkanes, 21 terpenes, 9 alcohols, 4 aldehydes and ketones, 3 aromatics, 2

  17. 3-O-sulfated heparan sulfate recognized by the antibody HS4C3 contributes [corrected] to the differentiation of mouse embryonic stem cells via fas signaling.

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    Kazumi Hirano

    Full Text Available Maintenance of self-renewal and pluripotency in mouse embryonic stem cells (mESCs is regulated by the balance between several extrinsic signaling pathways. Recently, we demonstrated that heparan sulfate (HS chains play important roles in the maintenance and differentiation of mESCs by regulating extrinsic signaling. Sulfated HS structures are modified by various sulfotransferases during development. However, the significance of specific HS structures during development remains unclear. Here, we show that 3-O-sulfated HS structures synthesized by HS 3-O-sulfotransferases (3OSTs and recognized by the antibody HS4C3 increase during differentiation of mESCs. Furthermore, expression of Fas on the cell surface of the differentiated cells also increased. Overexpression of the HS4C3-binding epitope in mESCs induced apoptosis and spontaneous differentiation even in the presence of LIF and serum. These data showed that the HS4C3-binding epitope was required for differentiation of mESCs. Up-regulation of the HS4C3-binding epitope resulted in the recruitment of Fas from the cytoplasm to lipid rafts on the cell surface followed by activation of Fas signaling. Indeed, the HS4C3-binding epitope interacted with a region that included the heparin-binding domain (KLRRRVH of Fas. Reduced self-renewal capability in cells overexpressing 3OST resulted from the degradation of Nanog by activated caspase-3, which is downstream of Fas signaling, and was rescued by the inhibition of Fas signaling. We also found that knockdown of 3OST and inhibition of Fas signaling reduced the potential for differentiation into the three germ layers during embryoid body formation. This is the first demonstration that activation of Fas signaling is mediated by an increase in the HS4C3-binding epitope and indicates a novel signaling pathway for differentiation in mESCs.

  18. Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.

    Directory of Open Access Journals (Sweden)

    Romain Desprat

    Full Text Available Insertional mutagenesis has emerged as a major obstacle for gene therapy based on vectors that integrate randomly in the genome. Reducing the genotoxicity of genomic viral integration can, in first approximation, be equated with reducing the risk of oncogene activation, at least in the case of therapeutic payloads that have no known oncogenic potential, such as the globin genes. An attractive solution to the problem of oncogene activation is the inclusion of insulators/enhancer-blockers in the viral vectors. In this study we have used Recombinase-Mediated Cassette Exchange to characterize the effect of integration of globin therapeutic cassettes in the presence or absence of the chicken HS4 and three other putative insulators inserted near Stil, Tal1 and MAP17, three well-known cellular proto-oncogenes in the SCL/Tal1 locus. We show that insertion of a Locus Control Region-driven globin therapeutic globin transgene had a dramatic activating effect on Tal1 and Map17, the two closest genes, a minor effect on Stil, and no effect on Cyp4x1, a non-expressed gene. Of the four element tested, cHS4 was the only one that was able to suppress this transgene-mediated insertional transcriptional activation. cHS4 had a strong suppressive effect on the activation expression of Map17 but has little or no effect on expression of Tal1. The suppressive activity of cHS4 is therefore promoter specific. Importantly, the observed suppressive effect of cHS4 on Map17 activation did not depend on its intercalation between the LCR and the Map 17 promoter. Rather, presence of one or two copies of cHS4 anywhere within the transgene was sufficient to almost completely block the activation of Map17. Therefore, at this complex locus, suppression of transgene-mediated insertional transcriptional activation by cHS4 could not be adequately explained by models that predict that cHS4 can only suppress expression through an enhancer-blocking activity that requires intercalation

  19. A Psicologia da Religião Ocidental e Oriental: a influência do círculo de Eranos no atendimento da religião na perspectiva de Carl Gustav Jung

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Lemos

    2014-03-01

    Full Text Available LEMOS, Luiz Henrique. A Psicologia da religião Ocidental e Oriental: a influência do círculo de Eranos no atendimento da religião na perspectiva de Carl Gustav Jung. 2013. 127f. Dissertação (Mestrado em Ciências da Religião – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

  20. Effect of Tanreqing injection on mycoplasma pneumonia in patients of hs-CRP, PCT, T cell subsets

    Institute of Scientific and Technical Information of China (English)

    Mei Bai

    2016-01-01

    Objective: To explore the effect of Tanreqing injection for treatment and its clinical significance through the changes of mycoplasma pneumonia patients with hs-CRP, PCT levels and cellular immune index. Method:A total of 114 cases of mycoplasma pneumonia, which were randomly divided into routine antibiotic treatment group (n=53) (control group), Tanreqing injection treatment group (n=61) (treatment group), to observe the two groups' hs-CRP and PCT levels in serum and the cellular immune regulation after treatment in patients, and contrast the curative effect. Results:the two groups before treatment, hs-CRP and PCT levels in serum had no significant difference;the treatment group after treatment, hs-CRP and PCT levels in serum were significantly lower than before treatment, and lower than that of the control group's;the control group after treatment of serum hs-CRP was significantly lower than that before treatment, compared to the before treatment, the level of PCT decreased slightly, but compared with before treatment there was no significant difference;after treatment, CD3+, CD4+, CD4+/CD8+, CD56+value were significantly higher than the control group's;CD8+and CD4+CD25+were significantly lower than the control group's;effective treatment group was significantly higher than the control group. The average hospitalization time was less than the control group's. Conclusion:Tanreqing injection adjuvant therapy could improve the treatment effect in mycoplasma pneumonia patients, regulate immune function, which was worth popularizing in clinical use.

  1. The Hydrogen Sulfide Donor NaHS Delays Programmed Cell Death in Barley Aleurone Layers by Acting as an Antioxidant.

    Science.gov (United States)

    Zhang, Ying-Xin; Hu, Kang-Di; Lv, Kai; Li, Yan-Hong; Hu, Lan-Ying; Zhang, Xi-Qi; Ruan, Long; Liu, Yong-Sheng; Zhang, Hua

    2015-01-01

    H2S is a signaling molecule in plants and animals. Here we investigated the effects of H2S on programmed cell death (PCD) in barley (Hordeum vulgare L.) aleurone layers. The H2S donor NaHS significantly delayed PCD in aleurone layers isolated from imbibed embryoless barley grain. NaHS at 0.25 mM effectively reduced the accumulation of superoxide anion (·O2 (-)), hydrogen peroxide (H2O2), and malondialdehyde (MDA), promoted the activity of superoxide dismutase (SOD), guaiacol peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX), and decreased those of lipoxygenase (LOX) in isolated aleurone layers. Quantitative-PCR showed that NaHS treatment of aleurone tissue led to enhanced transcript levels of the antioxidant genes HvSOD1, HvAPX, HvCAT1, and HvCAT2 and repressed transcript levels of HvLOX (lipoxygenase gene) and of two cysteine protease genes HvEPA and HvCP3-31. NaHS treatment in gibberellic acid- (GA-) treated aleurone layers also delayed the PCD process, reduced the content of ·O2 (-), and increased POD activity while decreasing LOX activity. Furthermore, α-amylase secretion in barley aleurone layers was enhanced by NaHS treatment regardless of the presence or absence of GA. These data imply that H2S acted as an antioxidant in delaying PCD and enhances α-amylase secretion regardless of the presence of GA in barley aleurone layers.

  2. The Hydrogen Sulfide Donor NaHS Delays Programmed Cell Death in Barley Aleurone Layers by Acting as an Antioxidant

    Directory of Open Access Journals (Sweden)

    Ying-Xin Zhang

    2015-01-01

    Full Text Available H2S is a signaling molecule in plants and animals. Here we investigated the effects of H2S on programmed cell death (PCD in barley (Hordeum vulgare L. aleurone layers. The H2S donor NaHS significantly delayed PCD in aleurone layers isolated from imbibed embryoless barley grain. NaHS at 0.25 mM effectively reduced the accumulation of superoxide anion (·O2-, hydrogen peroxide (H2O2, and malondialdehyde (MDA, promoted the activity of superoxide dismutase (SOD, guaiacol peroxidase (POD, catalase (CAT, and ascorbate peroxidase (APX, and decreased those of lipoxygenase (LOX in isolated aleurone layers. Quantitative-PCR showed that NaHS treatment of aleurone tissue led to enhanced transcript levels of the antioxidant genes HvSOD1, HvAPX, HvCAT1, and HvCAT2 and repressed transcript levels of HvLOX (lipoxygenase gene and of two cysteine protease genes HvEPA and HvCP3-31. NaHS treatment in gibberellic acid- (GA- treated aleurone layers also delayed the PCD process, reduced the content of ·O2-, and increased POD activity while decreasing LOX activity. Furthermore, α-amylase secretion in barley aleurone layers was enhanced by NaHS treatment regardless of the presence or absence of GA. These data imply that H2S acted as an antioxidant in delaying PCD and enhances α-amylase secretion regardless of the presence of GA in barley aleurone layers.

  3. Clinical Significance of MALB and hs-CRP in Patients with Unstable Angina Pectoris%不稳定型心绞痛患者测定UAER、hs-CRP的临床意义

    Institute of Scientific and Technical Information of China (English)

    赵有翼; 田东霞

    2012-01-01

    Objective To study the significance of urinary albumin excretion rate(UAER) and high sensitivity C-reactive protein (hs-CRP) in patients with unstable angina pectoris. Methods All 178 patients with unstable angina pectoris were divided into four groups. Initial onset angina pectoris group consisted of 46 patients, progressive angina pectoris group consisted of SO patients,spontaneous angina group consisted of 54 patients,and post-infarction angina pectoris group consisted of 28 patients. The level of UAER and hs-CRP were tested and the data were compared to that of 40 healthy controls. Results The levels of UAER and hs-CRP were higher both in initial onset angina pectoris group and progressive angina pectoris group than those of health con-trols(P <0.01). The UAER in post-infarction angina pectoris group was higher either( P < 0.05). Conclusion The level of UAER and hs-CRP in early periods of patients with unstable angina pectoris should be tested so as to get the best curing effect. Combining with myocardial zymogram and electrocardiogram examination,the proper therapy can prevent myocardial infarction.%目的 探讨尿微量白蛋白排泄率(UAER)与超敏C-反应蛋白(hs-CRP)在不稳定型心绞痛诊断中的临床意义.方法 将178例临床诊断为不稳定型心绞痛患者分为初发劳力型心绞痛组46例,恶化劳力型心绞痛组50例,自发型心绞痛组54例及梗死后心绞痛组28例;同期正常体检者40例作为对照组,分别应用免疫金标法测定尿微量白蛋白排泄率,免疫比浊法测定超敏C-反应蛋白水平,并进行比较.结果 初发型心绞痛组和恶化型心绞痛组的UAER及hs-CRP均有很大程度的增高,二者显著高于对照组(P<0.01);梗死后心绞痛组UAER明显高于对照组(P<0.05),hs-CRP在正常范围;自发型心绞痛组两项测定指标均在正常范围.结论 在心绞痛的早期应该注意监测UAER和hs-CRP的变化,以其尽早干预心绞痛的病程进展,对于

  4. Allelic Imbalance of mRNA Associated with α2-HS Glycoprotein (Fetuin-A Polymorphism

    Directory of Open Access Journals (Sweden)

    Yoshihiko Inaoka

    2015-01-01

    Full Text Available Alpha 2-HS glycoprotein (AHSG, also designated as fetuin-A, exhibits polymorphism in population genetics consisting of two major alleles of AHSG∗1 and AHSG∗2. The serum level in the AHSG∗1 homozygote is significantly higher than that of the AHSG∗2 homozygote. This study examined the molecular mechanism for the cis-regulatory expression. To quantitate allele-specific mRNA in intra-assays of the heterozygote, RT-PCR method employing primers that were incorporated to the two closely located SNPs was developed. The respective magnitudes of AHSG∗1 to AHSG∗2 in the liver tissues and hepatic culture cells of PLC/PRF/5 were determined quantitatively as 2.5-fold and 6.2-fold. The mRNA expressional difference of two major alleles was observed, which is consistent with that in the serum level. The culture cells carried heterozygous genotypes in rs4917 and rs4918, but homozygous one in rs2248690. It was unlikely that the imbalance was derived from the SNP located in the promotor site. Furthermore, to investigate the effect of mRNA degradation, RNA synthesis in the cell culture was inhibited potently by the addition of actinomycin-D. No marked change was apparent between the two alleles. The results indicated that the cis-regulatory expressional difference is expected to occur at the level of transcription or splicing of mRNA.

  5. Allelic Imbalance of mRNA Associated with α2-HS Glycoprotein (Fetuin-A) Polymorphism.

    Science.gov (United States)

    Inaoka, Yoshihiko; Osawa, Motoki; Mukasa, Nahoko; Miyashita, Keiko; Satoh, Fumiko; Kakimoto, Yu

    2015-01-01

    Alpha 2-HS glycoprotein (AHSG), also designated as fetuin-A, exhibits polymorphism in population genetics consisting of two major alleles of AHSG(∗) 1 and AHSG(∗) 2. The serum level in the AHSG(∗) 1 homozygote is significantly higher than that of the AHSG(∗) 2 homozygote. This study examined the molecular mechanism for the cis-regulatory expression. To quantitate allele-specific mRNA in intra-assays of the heterozygote, RT-PCR method employing primers that were incorporated to the two closely located SNPs was developed. The respective magnitudes of AHSG(∗) 1 to AHSG(∗) 2 in the liver tissues and hepatic culture cells of PLC/PRF/5 were determined quantitatively as 2.5-fold and 6.2-fold. The mRNA expressional difference of two major alleles was observed, which is consistent with that in the serum level. The culture cells carried heterozygous genotypes in rs4917 and rs4918, but homozygous one in rs2248690. It was unlikely that the imbalance was derived from the SNP located in the promotor site. Furthermore, to investigate the effect of mRNA degradation, RNA synthesis in the cell culture was inhibited potently by the addition of actinomycin-D. No marked change was apparent between the two alleles. The results indicated that the cis-regulatory expressional difference is expected to occur at the level of transcription or splicing of mRNA.

  6. Determination of benzene in different food matrices by distillation and isotope dilution HS-GC/MS

    Energy Technology Data Exchange (ETDEWEB)

    Medeiros Vinci, Raquel [Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent (Belgium); Canfyn, Michael [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium); De Meulenaer, Bruno [Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent (Belgium); Schaetzen, Thibault de; Van Overmeire, Ilse; De Beer, Jacques [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium); Van Loco, Joris, E-mail: Joris.VanLoco@iph.fgov.BE [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium)

    2010-07-05

    Benzene is classified by the IARC as carcinogenic to humans. Several sources may contribute for the occurrence of benzene in foods, such as, environmental contamination and the reaction of benzoate salts with ascorbic acid (naturally present or added as food additives). Matrix effect on benzene recovery (e.g. in fatty foods) and artefactual benzene formation from benzoate during analysis in the presence of ascorbate are some of the challenges presented when determining benzene in a wide range of foodstuffs. Design of experiment (DOE) was used to determine the most important variables in benzene recovery from headspace GC/MS. Based on the results of the DOE, a versatile method for the extraction of benzene from all kind of food commodities was developed. The method which consisted of distillation and isotope dilution HS-GC/MS was in-house validated. Artefactual benzene was prevented by addition of a borate buffer solution (pH 11) under distillation conditions. The method presented in this study allows the use of a matrix-independent calibration with detection limits below the legal limit established by the European Council for benzene in drinking water (1 {mu}g L{sup -1}).

  7. Determination of benzene in different food matrices by distillation and isotope dilution HS-GC/MS.

    Science.gov (United States)

    Vinci, Raquel Medeiros; Canfyn, Michael; De Meulenaer, Bruno; de Schaetzen, Thibault; Van Overmeire, Ilse; De Beer, Jacques; Van Loco, Joris

    2010-07-01

    Benzene is classified by the IARC as carcinogenic to humans. Several sources may contribute for the occurrence of benzene in foods, such as, environmental contamination and the reaction of benzoate salts with ascorbic acid (naturally present or added as food additives). Matrix effect on benzene recovery (e.g. in fatty foods) and artefactual benzene formation from benzoate during analysis in the presence of ascorbate are some of the challenges presented when determining benzene in a wide range of foodstuffs. Design of experiment (DOE) was used to determine the most important variables in benzene recovery from headspace GC/MS. Based on the results of the DOE, a versatile method for the extraction of benzene from all kind of food commodities was developed. The method which consisted of distillation and isotope dilution HS-GC/MS was in-house validated. Artefactual benzene was prevented by addition of a borate buffer solution (pH 11) under distillation conditions. The method presented in this study allows the use of a matrix-independent calibration with detection limits below the legal limit established by the European Council for benzene in drinking water (1 microg L(-1)).

  8. Integrated HS and ALS Remote Sensing Data Sources to Develop Green Corridors in Sopron Mountains

    Directory of Open Access Journals (Sweden)

    János Tamás

    2015-01-01

    Full Text Available The green corridors are part of the European Union rural landscapes, but the regional increase in size of agricultural parcels had a significant effect on European land use in the 20th century. This effect radically reduced the coverage of natural forest. One ecological problem with the remaining forests is the partial missing of the network connecting the parts with ecological green corridors. Another economical problem is the verifiability for the payment system of agroforestry. Remote sensing methods are currently used to supervise monitoring the arable lands, plantations, natural reserve areas, as well as to help for the European Union payment system. Nowadays the airborne hyperspectral (HS and LiDAR (Light Detection And Ranging; ALS remote sensing technologies are becoming of more widespread use. They can be applied especially in spatial decision support system (SDSS, used in decisions about for nature, environment, forests, agriculture protection, conservation and monitoring, as well as for monitoring of biomass production. Our site selection model was the first step towards planning an agroforestry plantation which uses these integrated technologies to connect the parts with green corridors.

  9. Subaru high resolution spectroscopy of complex metal absorption lines of QSO HS1603+3820

    CERN Document Server

    Misawa, T; Takada-Hidai, M; Wang, Y; Kashikawa, N; Iye, M; Tanaka, I; Misawa, Toru; Yamada, Toru; Takada-Hidai, Masahide; Wang, Yiping; Kashikawa, Nobunari; Iye, Masanori; Tanaka, Ichi

    2002-01-01

    We present a high resolution spectrum of the quasar, HS1603+3820 (z_em=2.542), observed with the High Dispersion Spectrograph (HDS) on Subaru Telescope. This quasar, first discovered in the Hamburg/CfA Quasar Survey, has 11 C IV lines at 1.96 2.29 and resolves some of them into multiple narrow components with b 65 km/s). We use three properties of C IV lines, specifically, time variability, covering factor, and absorption line profile, to classify them into quasar intrinsic absorption lines (QIALs) and spatially intervening absorption lines (SIALs). The C IV lines at 2.42 < z_abs < 2.45 are classified as QIALs in spite of their large velocity shifts from the quasar. Perhaps they are produced by gas clouds ejected from the quasar with the velocity of v_ej = 8000 km/s -- 10000 km/s. On the other hand, three C IV lines at 2.48 < z_abs < 2.55 are classified as SIALs, which suggests there exist intervening absorbers near the quasar. We, however, cannot rule out QIALs for the two lines at z_abs ~ 2.54...

  10. Time-Variable Complex Metal Absorption Lines in the Quasar HS1603+3820

    CERN Document Server

    Misawa, T; Charlton, J C; Tajitsu, A; Misawa, Toru; Eracleous, Michael; Charlton, Jane C.; Tajitsu, Akito

    2005-01-01

    We present a new spectrum of the quasar HS1603+3820 taken 1.28 years (0.36 years in the quasar rest frame) after a previous observation with Subaru+HDS. The new spectrum enables us to search for time variability as an identifier of intrinsic narrow absorption lines (NALs). This quasar shows a rich complex of C IV NALs within 60,000 km/s of the emission redshift. Based on covering factor analysis, Misawa et al. found that the C IV NAL system at z_abs= 2.42--2.45 (System A, at a shift velocity of v_sh = 8,300--10,600 km/s relative to the quasar) was intrinsic to the quasar. With our new spectrum, we perform time variability analysis as well as covering factor analysis to separate intrinsic NALs from intervening NALs for 8 C IV systems. Only System A, which was identified as an intrinsic system in the earlier paper by Misawa et al., shows a strong variation in line strength (W_obs ~ 10.4A -> 19.1A). We speculate that a broad absorption line (BAL) could be forming in this quasar. We illustrate the plausibility of...

  11. Study on the Aromatic Components of Green Plum Wine by HS-SPME-GC-MS

    Institute of Scientific and Technical Information of China (English)

    Yingying MA; Hechuan WU; Qingbin LIU; Lingyun WANG; Xiao DOU; Lin YANG; Jiangang YANG

    2016-01-01

    In order to better blend green plum wine and study aromatic components of green plum wine,a qualitative analysis on aromatic components of soaked base liquor,green plum soaked wine,green plum juice,and fermented wine of green plum juice by Head Space Solid-phase Microextraction( HS-SPME) and Gas Chromatograph Mass Spectrometer( GC-MS) was studied in this paper. Experiment results indicated that14,32,17,and 46 kinds of aromatic components were identified respectively from four samples. Different aromatic components determined the special flavor and taste of green plum wine. Unique aromatic components generated in soaking process include benzaldehyde,1-butanol,2-methyl-,S-(-),benzoic acid ethyl ester,and 5-( hydroxymethyl). Special aromatic components in green plum juice were furfural,phenylethyl alcohol,and benzyl alcohol. The aromatic components in fermented wine of green plum juice mainly included phenylethyl alcohol( 6. 941%,relative content of peak area,same below),1-butanol,3-methyl-( 6. 940%),octanoic acid,ethyl ester( 3. 734%),decanoic acid,ethyl ester( 2. 590%),hexanoic acid,ethyl ester( 2. 479%),ethyl 9-decenoate( 2. 080%),and 5-hydroxymethyl( 1. 756%). This study was expected to provide scientific basis and data reference for quality improvement of green plum wine.

  12. Developing an emulsion model system containing canthaxanthin biosynthesized by Dietzia natronolimnaea HS-1.

    Science.gov (United States)

    Gharibzahedi, Seyed Mohammad Taghi; Razavi, Seyed Hadi; Mousavi, Seyed Mohammad

    2012-11-01

    An acceptable strategy to incorporate canthaxanthin (CX) as a natural colorant into products is by means of oil-in-water emulsions. The used CX in this study was produced by bacterium Dietzia natronolimnaea HS-1 using a batch bioreactor system. A central composite rotatable design-response surface methodology (CCRD-RSM) consisting of three-factored factorial design with five levels was applied for analysis of the results to obtain the optimal formulation of emulsions. Three independent variables including fenugreek gum (FG, 0.2-0.5%, w/w), coconut oil (CO, 6-10%, w/w), and CO/CX ratio (10:1-50:1) were transformed to coded values and second-order polynomial models was developed to predict the responses (pproperties such as volume-weighted mean diameter (D₄₃), specific surface area (S(v)) and polydispersity index (PDI) of emulsions. The 3-D response surface plot derived from the mathematical models was used to determine the optimal conditions. Main emulsion components under the optimum conditions ascertained presently by RSM: 50:1 CO/CX ratio, 0.49% (w/w) FG content and 6.28% (w/w) CO concentration. At this optimum point, stability, viscosity, D₄₃, S(v) and PDI were 90.6%, 0.0118 Pas, 0.595 μm, 12.03 m²/ml and 1.380, respectively.

  13. Canthaxanthin biosynthesis by Dietzia natronolimnaea HS-1: effects of inoculation and aeration rate

    Directory of Open Access Journals (Sweden)

    Forouzan Rostami

    2014-06-01

    Full Text Available The interest in production of natural colorants by microbial fermentation has been currently increased. The effects of D-glucose concentration (3.18-36.82 g/L, inoculum size (12.5 x 10(9-49.5 x 10(9 cfu cells/mL and air-flow rate (1.95-12.05 L/L min on the biomass, total carotenoid and canthaxanthin (CTX accumulation of Dietzia natronolimnaea HS-1 in a batch bioreactor was scrutinized using a response surface methodology-central composite rotatable design (RSM-CCRD. Second-order polynomial models with high R² values ranging from 0.978 to 0.990 were developed for the studied responses using multiple linear regression analysis. The models showed the maximum cumulative amounts of biomass (7.85 g/L, total carotenoid (5.48 mg/L and CTX (4.99 mg/L could be achieved at 23.38 g/L of D-glucose, 31.2 x 10(9 cfu cells/mL of inoculation intensity and air-flow rate of 7.85 L/L min. The predicted values for optimum conditions were in good agreement with experimental data.

  14. The orbital and superhump periods of the dwarf nova HS 0417+7445 in Camelopardalis

    CERN Document Server

    Shears, J H; Brady, S; Dubovsky, P; Miller, I; Staels, B

    2010-01-01

    We present the 2005-2010 outburst history of the SUUMa-type dwarf HS 0417+7445,along with a detailed analysis of extensive time-series photometry obtained in March 2008 during the second recorded superoutburst of the system. The mean outburst interval is 197 \\pm 59 d, with a median of 193 d. The March 2008 superoutburst was preceeded by a precursor outburst, had an amplitude of 4.2 magnitudes, and the whole event lasted about 16 days. No superhumps were detected during the decline from the precursor outburst, and our data suggests instead that orbital humps were present during that phase. Early superhumps detected during the rise to the superoutburst maximum exhibited an unusually large fractional period excess of epsilon = 0.137 (Psh = 0.0856(88) d). Following the maximum, a linear decline in brightness followed, lasting at least 6 days. During this decline, a stable superhump period of Psh = 0.07824(2) d was measured. Superimposed on the superhumps were orbital humps, which allowed us to accurately measure ...

  15. Production and decay of element 114: high cross sections and the new nucleus 277Hs

    Energy Technology Data Exchange (ETDEWEB)

    Dullmann, Ch.E.; Schadel, M.; Yakushev, A.; Turler, A.; Eberhardt, K.; Kratz, J.V.; Ackermann, D.; Andersson, L.-L.; Block, M.; Bruchle, W.; Dvorak, J.; Essel, H.G.; Ellison, P.A.; Even, J.; Gates, J.M.; Gorshkov, A.; Graeger, R.; Gregorich, K.E.; Hartmann, W.; Herzberg, R.-D.; Hessberger, F.P.; Hild, D.; Hubner, A.; Jager, E.; Khuyagbaatar, J.; Kindler, B.; Krier, J.; Kurz, N.; Lahiri, S.; Liebe, D.; Lommel, B.; Maiti, M.; Nitsche, H.; Omtvedt, J.P.; Parr, E.; Rudolph, D.; Runke, J.; Schausten, B.; Schimpf, E.; Semchenkov, A.; Steiner, J.; Thorle-Pospiech, P.; Uusitalo, J.; Wegrzecki, M.; Wiehl, N.

    2009-12-22

    The fusion-evaporation reaction {sup 244}Pu({sup 48}Ca,3-4n){sup 288,289}114 was studied at the new gas-filled recoil separator TASCA. Thirteen correlated decay chains were observed and assigned to the production and decay of {sup 288,289}114. At a compound nucleus excitation energy of E* = 39.8-43.9 MeV, the 4n evaporation channel cross section was 9.8{sub -3.1}{sup +3.9} pb. At E* = 36.1-39.5 MeV, that of the 3n evaporation channel was 8.0{sub -4.5}{sup +7.4} pb. In one of the 3n evaporation channel decay chains, a previously unobserved {alpha} branch in {sup 281}Ds was observed (probability to be of random origin from background: 0.1%). This {alpha} decay populated the new nucleus {sup 277}Hs, which decayed by spontaneous fission after a lifetime of 4.5 ms.

  16. Analysis of Five Earthy-Musty Odorants in Environmental Water by HS-SPME/GC-MS

    Directory of Open Access Journals (Sweden)

    Zhen Ding

    2014-01-01

    Full Text Available The pressing issue of earthy and musty odor compounds in natural waters, which can affect the organoleptic properties of drinking water, makes it a public health concern. A simple and sensitive method for simultaneous analysis of five odorants in environmental water was developed by headspace solid-phase microextraction (HS-SPME coupled to chromatography-mass spectrometry (GC-MS, including geosmin (GSM and 2-methylisoborneol (2-MIB, as well as dimethyl trisulfide (DMTS, β-cyclocitral, and β-ionone. Based on the simple modification of original magnetic stirrer purchased from CORNING (USA, the five target compounds can be separated within 23 min, and the calibration curves show good linearity with a correlation coefficient above 0.999 (levels = 5. The limits of detection (LOD are all below 1.3 ng L−1, and the relative standard deviation (%RSD is between 4.4% and 9.9% (n = 7 and recoveries of the analytes from water samples are between 86.2% and 112.3%. In addition, the storage time experiment indicated that the concentrations did not change significantly for GSM and 2-MIB if they were stored in canonical environment. In conclusion, the method in this study could be applied for monitoring these five odorants in natural waters.

  17. Stabilization of canthaxanthin produced by Dietzia natronolimnaea HS-1 with spray drying microencapsulation.

    Science.gov (United States)

    Hojjati, Mohammad; Razavi, Seyed Hadi; Rezaei, Karamatollah; Gilani, Kambiz

    2014-09-01

    The strain bacterium Dietzia natronolimnaea has propounded as a source for biological production of canthaxanthin. Because of sensitivity of this pigment, examine on its stability is important. In this study, stability of encapsulated canthaxanthin from D. natronolimnaea HS-1 using soluble soybean polysaccharide (SSPS), gum acacia (GA), and maltodextrin (MD) as wall materials was investigated at 4, 25, and 45 °C in light and dark conditions during 4 months of storage. It was shown that the type of walls influenced the size of emulsion droplets; spray dried particles, microencapsulation efficiency (ME), and retention of canthaxanthin in microcapsules. SSPS and MD produced the smallest and the biggest emulsion droplets and spray dried particles, respectively. Microcapsules made with SSPS resulted in better ME and higher stability for canthaxanthin. Samples were degraded in all conditions, especially in light and 45 °C. Degradation of microencapsulated canthaxanthin with SSPS and GA proceeded more slowly than did with MD. Regardless of the type of wall materials, total canthaxanthin contents of the microencapsulated products decreased by an increase in time or temperature. Also, samples exposed to light indicated less stability at 4 and 25 °C when compared to the storage at dark conditions. According to the results of this study, SSPS can be considered as potential wall material for the encapsulation of carotenoids.

  18. Definition of the switch surface in the solution structure of Cdc42Hs.

    Science.gov (United States)

    Feltham, J L; Dötsch, V; Raza, S; Manor, D; Cerione, R A; Sutcliffe, M J; Wagner, G; Oswald, R E

    1997-07-22

    Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of pathways leading to cell growth and the establishment of cell polarity and mobility. Presented here is the solution structure of one such protein, Cdc42Hs, which provides insight into the structural basis for specificity of interactions between this protein and its effector and regulatory proteins. Standard heteronuclear NMR methods were used to assign the protein, and approximately 2100 distance and dihedral angle constraints were used to calculate a set of 20 structures using a combination of distance geometry and simulated annealing refinement. These structures show overall similarity to those of other GTP-binding proteins, with some exceptions. The regions corresponding to switch I and switch II in H-ras are disordered, and no evidence was found for an alpha-helix in switch II. The 13-residue insertion, which is only present in rho-subtype proteins and has been shown to be an important mediator of binding of regulatory and target proteins, forms a compact structure containing a short helix lying adjacent to the beta4-alpha3 loop. The insert forms one edge of a "switch surface" and, unexpectedly, does not change conformation upon activation of the protein by the exchange of GTP analogs for GDP. These studies indicate the insert region forms a stable invariant "footrest" for docking of regulatory and effector proteins.

  19. Os tipos psicológicos na psicologia analítica de Carl Gustav Jung e o inventário de personalidade “Myers-Briggs Type Indicator (MBTI)”: contribuições para a psicologia educacional, organizacional e clínica/The psychological types in analytical psychology of Carl Gustav Jung and the inventory of personality “Myers-Briggs Type Indicator (MBTI)”: contributions for the educational, organizational and clinical psychology

    OpenAIRE

    Luís Marcelo Alves Ramos

    2005-01-01

    O texto apresenta os princípios da Teoria dos Tipos Psicológicos, a mais conhecida face da Psicologia Analítica do psicólogo e psiquiatra suíço Carl Gustav Jung (1875-1961), bem como os fundamentos do Inventário de Personalidade “Myers-Briggs Type Indicator (MBTI)”, constituído a partir da tipologia junguiana, e que vem sendo cada vez mais utilizado nos campos da Psicologia Educacional, Organizacional e Clínica. Palavras-chave Psicologia analítica; Teorias da personalidade; Tipos psi...

  20. Tissue-Specific Methylation of Long Interspersed Nucleotide Element-1 of Homo Sapiens (L1Hs) During Human Embryogenesis and Roles in Neural Tube Defects.

    Science.gov (United States)

    Wang, L; Chang, S; Guan, J; Shangguan, S; Lu, X; Wang, Z; Wu, L; Zou, J; Zhao, H; Bao, Y; Qiu, Z; Niu, B; Zhang, T

    2015-01-01

    Epigenetic regulation of long interspersed nucleotide element-1 (LINE-1) retrotransposition events plays crucial roles during early development. Previously we showed that LINE-1 hypomethylation in neuronal tissues is associated with pathogenesis of neural tube defect (NTD). Herein, we further evaluated LINE-1 Homo sapiens (L1Hs) methylation in tissues derived from three germ layers of stillborn NTD fetuses, to define patterns of tissue specific methylation and site-specific hypomethylation at CpG sites within an L1Hs promoter region. Stable, tissue-specific L1Hs methylation patterns throughout three germ layer lineages of the fetus, placenta, and maternal peripheral blood were observed. Samples from maternal peripheral blood exhibited the highest level of L1Hs methylation (64.95%) and that from placenta showed the lowest (26.82%). Between samples from NTDs and controls, decrease in L1Hs methylation was only significant in NTD-affected brain tissue at 7.35%, especially in females (8.98%). L1Hs hypomethylation in NTDs was also associated with a significant increase in expression level of an L1Hs-encoded transcript in females (r = -0.846, p = 0.004). This could be due to genomic DNA instability and alternation in chromatins accessibility resulted from abnormal L1Hs hypomethylation, as showed in this study with HCT-15 cells treated with methylation inhibitor 5-Aza.

  1. Effect of soil fulvic and humic acid on binding of Pb to goethite–water interface: Linear additivity and volume fractions of HS in the Stern layer

    NARCIS (Netherlands)

    Xiong, J.; Koopal, L.K.; Weng, L.; Wang, J.; Tan, W.

    2015-01-01

    The effects of soil fulvic (JGFA) and humic acid (JGHA) on Pb binding to goethite were investigated with batch experiments and modeling. The CD-MUSIC and NICA-Donnan model could describe the Pb binding to, respectively, the binary Pb–goethite and Pb–HS systems. The adsorption of humic substances (HS

  2. 血清hs-CRP测定对糖尿病并发脑梗死患者的临床意义

    Institute of Scientific and Technical Information of China (English)

    陈干明; 王晴; 张欣中

    2012-01-01

    目的 探讨糖尿病并发急性脑梗死患者血清hs-CRP水平与病情及预后的关系.方法 测定88例糖尿病并发急性脑梗死患者血清hs-CRP含量,分析与病情及预后关系.结果 糖尿病并发急性脑梗死患者血清hs-CRP水平明显高于糖尿病并发脑腔隙性脑梗死患者(P<0.01);脑梗死重型组血清hs-CRP水平高于中型、轻型组(P<0.05);随防1年,血清hs-CRP水平高者易复发.结论 糖尿病并发急性脑梗死患者血清hs-CRP水平升高,提示患者病情重、预后差、易复发.早期测定血清hs-CRP水平有助于评估糖尿病并发急性脑梗死的病情及预后.%Objective To the correlation of the serum hs - CRP level, the clinical situation and the prognosis of the patient with diabetes complicated with acute cerebral infarction. Methods 88 patients with diabetes complicated with acute cerebral infarction were measure of their serum hs - CRP level, the correlation to the clinical situation and prognosis was ananlyzed. Results The serum hs - CRP level of the patient with diabetes complicated with acute cerebral infarction was significantly higher than that of the patient with diabetes complicated with cerebral lacunar infarction ( P < 0. 01) , the serum hs - CRP level was higher in the severe infarction than in the medium and mild group ( P < 0. 05) , the patients were followed up for one year and those with high level of serum hs - CRP was more easy for relatpsing. Conclusions The serum hs - CRP level in the patient with diabetes complicated with acute cerebral infarction is elevated, which indicates a more severe clinical situation and poor prognosis. The early measurement of serum hs - CRP helps for the evaluation of diabetes complicated with acute cerebral infarction and its prognosis.

  3. Resting Serum Concentration of High-Sensitivity C-Reactive Protein (hs-CRP) in Sportsmen and Untrained Male Adults.

    Science.gov (United States)

    Niyi-Odumosu, F A; Bello, O A; Biliaminu, S A; Owoyele, B V; Abu, T O; Dominic, O L

    2017-03-06

    There is an inverse relationship between regular physical activity and concentration of serum inflammatory markers, with variations in resting CRP in trained and untrained subjects. The effect of acute and prolonged exercises has been studied on inflammatory markers with dearth of information and controversies on the resting serum values of high sensitivity CRP (hs-CRP). Therefore, this study sought to identify and compare variations that occur in serum levels of high sensitivity CRP in groups of sportsmen (6) and physically active untrained subjects. Eighty-one healthy male participants made up of 21 untrained (control), 10 footballers, 10 athletes, 10 karates, 10 volleyballers, 10 basketballers, and 10 baseballers voluntarily participated in the study. Participants rested while in sitting position for about 30 minutes during which blood pressures and heart rates were taken. 5 mls of venous blood was withdrawn from the antecubital vein of the participants (aseptically) between 7:00 and 10:00 am into lithium heparin bottles following an overnight fast. The supernatant was decanted and centrifuged at 3000 rpm, serum was collected and stored at -20ºC prior to biochemical assay which was done with the use of enzyme linked immunosorbent assay (ELISA) kits for hs-CRP. Differences in the means within the sporting groups were analysed using one-way ANOVA while the difference between the trained sportsmen and untrained young adults was analysed using the independent T-test. Statistical significance was set at p hs-CRP (µg/ml) was 1.0±0.2 in the untrained, 2.6±0.7 in footballers, 3.6±2.1 in track athletes, 2.4±0.5 in basketballers, 2.2±0.5 in volleyballers, 2.4±1.3 in baseballers, and 1.7±0.5 in karate respectively. There was no significant difference in the resting hs-CRP amongst the sporting groups, and in the sportsmen and untrained group. Resting serum levels of hs-CRP falls within normal range, and varies insignificantly in groups of sports, and in sportsmen

  4. Hans, Choi immunophenotyping and C-MYC genetic features between pediatric and adult diffuse large B-cell lymphoma%儿童与成人弥漫大B细胞淋巴瘤的Hans、Choi免疫分型和C-MYC基因特征

    Institute of Scientific and Technical Information of China (English)

    徐红艳; 黄慧; 杨文萍; 黄传生; 钟梅慧

    2013-01-01

    Objective To explore the difference of Hans,Choi immunophenotyping and C-MYC gene characteristics between pediatric and adult diffuse large B-cell lymphoma.Methods To collect 60 cases of DLBCL clinicopathological data and follow-up,which contained 17 cases of children group,adult group of 43 patients.To observe CD10,BCL-6,MUM1,FOXP1,GCET1 and CD5 protein expression by immunohistochemical SP method and evaluated by Hans and Choi immunophenotyping standard genotyping.To detect C-MYC gene circumstances by interphase fluorescence insituhybridization (FISH).Results 1) Hans typing:the Children DLBCL group of GCB were 11 cases,non-GCB type were 6 cases; the GCB type in the adult DLBCL group were nine cases,non-GCB type were 34 cases.2)Choi typing:the Children DLBCL group of GCB type were 13 cases,ABC type were 4 cases; the adult DLBCL group of GCB type were 13 cases,ABC type were 30 cases (P < 0.01).3) C-MYC gene:The C-MYC gene disruption of children DLBCL were 5 cases; C-MYC gene in 43 adult cases were normal(P <0.01).Conclusions Child DLBCL of GCB-type with better prognosis while but non-GCB-type predict worse prognosis.The C-MYC gene disruption in Children DLBCL was significantly higher than that of adult ones.%目的 探讨弥漫大B细胞淋巴瘤(DLBCL)各年龄组的Hans、Choi免疫分型及C-MYC基因特征.方法 收集60例DLBCL临床病理资料并进行随访,其中儿童组17例、成人组43例.用免疫组化SP法观察CD10、BCL-6、MUM1、FOXP1、GCET1及CD5蛋白表达,根据Hans及Choi免疫分型标准分型;用间期荧光原位杂交法检测C-MYC 基因.结果 1)Hans分型:儿童DLBCL组GCB型11例,non-GCB型6例;成人组DLBCL中GCB型9例,non-GCB型34例(P<0.05).2) Choi分型:儿童DLBCL组GCB型13例,ABC型4例;成人DLBCL组GCB型13例,ABC型30例(P<0.01).3) C-MYC基因:儿童组DLBCL中C-MYC基因断裂6例;成人组DLBCL中C-MYC基因正常43例(P<0.01).结论 儿童DLBCL以GCB型为主,预后较好;成人DLBCL以non-GCB

  5. Advances in understanding of soil biogeochemical cycles: the mechanism of HS entry into the root interior

    Science.gov (United States)

    Aleksandrova, Olga

    2017-04-01

    Humic substances represent the major reservoir of carbon (C) in ecosystems, and their turnover is crucial for understanding the global C cycle. As shown by some investigators [1-2], the phenomenon of the uptake of the whole humic particles by plant roots is a significant step of biogeochemical cycle of carbon in soils. The mechanism of HS entry the root interior remained unknown for a long time. However recently, the last one was discovered [3]. An advanced model [3] includes two hypotheses. These hypotheses are as follows: (1) each nano-size particle possesses a quantum image that can be revealed as a packet of electromagnetic waves; (2) the interaction of nano-size particle with the membrane (plasma membrane) of living cells, on which it is adsorbed, occurs via the development of the Rayleigh-Taylor (RT) instability on the membrane surface. An advanced model allows us to look insight some into some phenomena that were observed by experiments but remained not understood [2]. The authors [2] applied tritium autoradiography to wheat seedlings cultivated with tritium-labeled HS to consider the uptake of humic particles by plant roots. They found a significant increase in the content of some polar (monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), sulfoquinovosyl diacylglycerol (SQDG) and phosphatidylcholine (PC)) and neutral (free fatty acids, FFA) lipids which were detected in the wheat seedlings treated with humic particles. Authors [2] pointed that lipids MGDG, DGDG, SQDG are crucial for functional and structural integrity of the photosystem complex. Therefore, a stimulating action of adsorbed humic particles evoked phenomena like photosynthesis in root cells that can be interpreted using an advanced model: humic particles being nano-size particles become adsorbed on the plant roots in soils, and influence their micro environment, where they are located, with the specific electromagnetic exposure. Another finding of authors consisted in the

  6. Urban Transformation and Property Value Variation. The Role of HS Stations

    Directory of Open Access Journals (Sweden)

    Carmela Gargiulo

    2010-04-01

    operation, partly in operation or not yet in operation. Besides, the description of each case is divided into: summary description of the characteristics of the HS railway line; description of the main features of cities that represent the nodes of the selected routes; identify the characteristics of the surrounding context of the railway station; measurement of the change in property values in the surrounding context of the railway station due to HS link. The third part provides a comparative outline of the effects of High Speed stations on property values and the urban typologies and characteristics that influence this relation. The first result of this article is a comparative framework between all study cases. In conclusion, the comparative reading shows that the effect from opening of the High Speed railway stations on property values is valuable in cases where it contributes significantly to raising the socio-economic and the quality conditions of spaces.

  7. Theses\\' subjects chosen from public needs: Experience of Yazd Health Study (YaHS

    Directory of Open Access Journals (Sweden)

    AA Dehghanitaftiti

    2014-12-01

    Full Text Available Yazd Health Study (YaHS is an endeavor to involve students in design, implementation and analysis of a large study. Over 150 graduate and post graduate students from various disciplines have been invited to participate in a large longitudinal study with 10000 samples. Participants were selected randomly from Yazd population, over 1000000 as December 2014. Four hundred variables grouped in the following sections were asked 1 demographics, 2 physical activity, 3sleep quality and quantity, 4 mental health, 5 history y of chronic illnesses, 6 history of surgical operations, 7 dental health, 8 history of accidents, 9 dietetic habits, 10 occupation and communication history, 11 traditional medicine, 12 history of smoking and addiction and 13 women’s health. The interview follows by anthropometric measurements including weight, height, BMI, waist circumference, hip circumference, neck circumference and WHR. Per cent body fat, % body muscle, visceral fat, resting metabolism have been measured followed by pulse and blood pressure. Students were trained to participate in design, piloting and the main phase of data collection. Students evaluated the experience useful and constructive. In return of their collaboration in interviewing 50-100 study participants, they will receive data for their theses' proposal. This will help them to access a large and high quality set of data and disseminate the results in high quality peer reviewed journals as well as national and international conferences. The students mandated to write an executive summary of their thesis and disseminate it to health managers and inter-sectoral decision makers. They will gain bonus score if they can publish their main findings in public media. Acknowledgments: Thanks to students who participated in the study and A. Professor Masoud Mirzaei, the principal investigator of Yazd Health Study (YAHS for providing information on the design and the progress of the study.

  8. Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Jong Hyuk; Kim, Jaeyoon; Lee, Hyeongjoo [NovaCell Technology Inc., Pohang, Kyungbuk 790-784 (Korea, Republic of); Kim, So Young [Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-756 (Korea, Republic of); Department of Convergence Medicine and Pharmaceutical Biosciences, Graduate School, Chung-Ang University, Seoul 156-756 (Korea, Republic of); Jang, Hwan-Hee [Functional Food and Nutrition Division, Department of Agrofood Resources, Rural Development Administration, Suwon 441-853 (Korea, Republic of); Ryu, Sung Ho [Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk 790-784 (Korea, Republic of); Kim, Beom Joon [Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-756 (Korea, Republic of); Department of Convergence Medicine and Pharmaceutical Biosciences, Graduate School, Chung-Ang University, Seoul 156-756 (Korea, Republic of); Lee, Taehoon G., E-mail: taehoon@novacelltech.com [NovaCell Technology Inc., Pohang, Kyungbuk 790-784 (Korea, Republic of)

    2012-11-23

    Highlights: Black-Right-Pointing-Pointer We identify a function of the YIGSR peptide to enhance collagen synthesis in Hs27. Black-Right-Pointing-Pointer YIGSR peptide enhanced collagen type 1 synthesis both of gene and protein levels. Black-Right-Pointing-Pointer There were no changes in cell proliferation and MMP-1 level in YIGSR treatment. Black-Right-Pointing-Pointer The YIGSR effect on collagen synthesis mediated activation of FAK, pyk2 and ERK. Black-Right-Pointing-Pointer The YIGSR-induced FAK and ERK activation was modulated by FAK and MEK inhibitors. -- Abstract: The dermal ECM is synthesized from fibroblasts and is primarily compromised of fibrillar collagen and elastic fibers, which support the mechanical strength and resiliency of skin, respectively. Laminin, a major glycoprotein located in the basement membrane, promotes cell adhesion, cell growth, differentiation, and migration. The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the {beta}1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. In this study, we identified a novel function of the YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts. To elucidate this novel function regarding collagen synthesis, we treated human dermal fibroblasts with YIGSR peptide in both a time- and dose-dependent manner. According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. This YIGSR peptide-mediated collagen type 1 synthesis was modulated by FAK inhibitor and MEK inhibitor. This study clearly reveals that YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate

  9. Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation

    Directory of Open Access Journals (Sweden)

    Lauren E. Musumeci

    2015-07-01

    Full Text Available Analyses of key odorous polyfunctional volatile thiols in wines (3-mercaptohexanol (3-MH, 3-mercaptohexylacetate (3-MHA, and 4-mercapto-4-methyl-2-pentanone (4-MMP are challenging due to their high reactivity and ultra-trace concentrations, especially when using conventional gas-chromatography electron impact mass spectrometry (GC-EI-MS. We describe a method in which thiols are converted to pentafluorobenzyl (PFB derivatives by extractive alkylation and the organic layer is evaporated prior to headspace solid phase microextraction (HS-SPME and GC-EI-MS analysis. Optimal parameters were determined by response surface area modeling. The addition of NaCl solution to the dried SPME vials prior to extraction resulted in up to less than fivefold improvement in detection limits. Using 40 mL wine samples, limits of detection for 4-MMP, 3-MH, and 3-MHA were 0.9 ng/L, 1 ng/L, and 17 ng/L, respectively. Good recovery (90%–109% and precision (5%–11% RSD were achieved in wine matrices. The new method was used to survey polyfunctional thiol concentrations in 61 commercial California and New York State wines produced from V. vinifera (Riesling, Gewürztraminer, Cabernet Sauvignon, Sauvignon blanc and non-varietal rosé wines, V. labruscana (Niagara, and Vitis spp. (Cayuga White. Mean 4-MMP concentrations in New York Niagara (17 ng/L were not significantly different from concentrations in Sauvignon blanc, but were significantly higher than 4-MMP in other varietal wines.

  10. Online breath gas analysis in unrestrained mice by hs-PTR-MS.

    Science.gov (United States)

    Szymczak, Wilfried; Rozman, Jan; Höllriegl, Vera; Kistler, Martin; Keller, Stefan; Peters, Dominika; Kneipp, Moritz; Schulz, Holger; Hoeschen, Christoph; Klingenspor, Martin; de Angelis, Martin Hrabě

    2014-04-01

    The phenotyping of genetic mouse models for human disorders may greatly benefit from breath gas analysis as a noninvasive tool to identify metabolic alterations in mice. Phenotyping screens such as the German Mouse Clinic demand investigations in unrestrained mice. Therefore, we adapted a breath screen in which exhaled volatile organic compounds (VOCs) were online monitored by proton transfer reaction mass spectrometry (hs-PTR-MS). The source strength of VOCs was derived from the dynamics in the accumulation profile of exhaled VOCs of a single mouse in a respirometry chamber. A careful survey of the accumulation revealed alterations in the source strength due to confounders, e.g., urine and feces. Moreover changes in the source strength of humidity were triggered by changes in locomotor behavior as mice showed a typical behavioral pattern from activity to settling down in the course of subsequent accumulation profiles. We demonstrated that metabolic changes caused by a dietary intervention, e.g., after feeding a high-fat diet (HFD) a sample of 14 male mice, still resulted in a statistically significant shift in the source strength of exhaled VOCs. Applying a normalization which was derived from the distribution of the source strength of humidity and accounted for varying locomotor behaviors improved the shift. Hence, breath gas analysis may provide a noninvasive, fast access to monitor the metabolic adaptation of a mouse to alterations in energy balance due to overfeeding or fasting and dietary macronutrient composition as well as a high potential for systemic phenotyping of mouse mutants, intervention studies, and drug testing in mice.

  11. 中度嗜盐菌HS1产纤维素酶发酵条件的研究%Study on Cellulase Production by A Moderately Halophilic Bacterium HS1

    Institute of Scientific and Technical Information of China (English)

    韩秋菊; 张倩倩

    2011-01-01

    对一株中度嗜盐菌HS1产纤维素酶的活性进行了初步研究.单因素实验和正交实验结果表明,菌株HS1产纤维素酶的最佳发酵氮源为1.5%NaNO3,优化的发酵条件为:液体种子接种量6%、培养温度35℃、初始pH值6.5、培养时间4 d.%In this paper, cellulase production by a moderately halophilic bacterium HS1 was preliminarily explored. Through single factor experiment and orthogonal experiment, it was found that the optimal nitrogen source was 1.5% NaNO3 for production of cellulase and the optimum fermentation conditions were as follows:inoculating quantity of liquid seed of 6% ,culture temperature of 35℃, initial pH value of 6.5 and culture time of 4 d.

  12. Optimization of HS-GC-FID-MS Method for Residual Solvent Profiling in Active Pharmaceutical Ingredients Using DoE.

    Science.gov (United States)

    Poceva Panovska, Ana; Acevska, Jelena; Stefkov, Gjoshe; Brezovska, Katerina; Petkovska, Rumenka; Dimitrovska, Aneta

    2016-02-01

    Within this research, a headspace (HS) gas chromatography-flame ionization detector-mass spectrometry method was developed for profiling of residual solvents (RSs) in active pharmaceutical ingredients (APIs). Design of experiment was used for optimization of sample preparation, as well as for robustness testing of the method. HS equilibration temperature and dilution medium were detected as parameters with greater impact on the sensitivity, compared with the time used for equilibration of the samples. Regardless of the sample solubility, the use of water for sample preparation was found to be crucial for better sensitivity. The use of a well-designed strategy for method development and robustness testing, additional level of identification confidence, as well as use of internal standard provided a strong and reliable analytical tool for API fingerprinting, thus enabling the authentication of the substance based on the RS profile.

  13. On the Highest Oxidation States of Metal Elements in MO4 Molecules (M = Fe, Ru, Os, Hs, Sm, and Pu).

    Science.gov (United States)

    Huang, Wei; Xu, Wen-Hua; Schwarz, W H E; Li, Jun

    2016-05-02

    Metal tetraoxygen molecules (MO4, M = Fe, Ru, Os, Hs, Sm, Pu) of all metal atoms M with eight valence electrons are theoretically studied using density functional and correlated wave function approaches. The heavier d-block elements Ru, Os, Hs are confirmed to form stable tetraoxides of Td symmetry in (1)A1 electronic states with empty metal d(0) valence shell and closed-shell O(2-) ligands, while the 3d-, 4f-, and 5f-elements Fe, Sm, and Pu prefer partial occupation of their valence shells and peroxide or superoxide ligands at lower symmetry structures with various spin couplings. The different geometric and electronic structures and chemical bonding types of the six iso-stoichiometric species are explained in terms of atomic orbital energies and orbital radii. The variations found here contribute to our general understanding of the periodic trends of oxidation states across the periodic table.

  14. 25(OHD was Correlated with Increased Risk of Insulin Resistance, but Not Mediated by Adiponectin and hsCRP

    Directory of Open Access Journals (Sweden)

    Anggi Kartikawati

    2012-08-01

    Full Text Available BACKGROUND: Studies have shown that change of calcium and vitamin D homeostasis is associated with insulin resistance, decreased beta cell function, metabolic syndrome, glucose intolerance and diabetes. Evidence suggests that vitamin D insufficiency is inversely related to risk of metabolic disorders including type-2 Diabetes Mellitus (T2DM, although the underlying mechanisms are not yet understood. Hence, current study was conducted to investigate correlation between 25(OHD and insulin resistance through adiponectin or High Sensitivity C-Reactive Protein (hsCRP in centrally obese men. METHODS: This was a cross-sectional study involving 80 centrally obese men with waist circumference (WC >90 cm and age 30-60 years. Total 25(OHD concentration was measured by Enzyme-Linked Immunosorbent Assay (ELISA method. Insulin resistance was calculated by HOMA model. RESULTS: This study showed there was no correlation of 25(OHD-WC (r=0.006 and p=0.957, 25(OHD-adiponectin (r=0.179 and p=0.111 abd 25(OHD-hsCRP (r=-0.223 and p=0.334, but we observed  statistically significant negative correlation between 25(OHD and insulin resistance index (HOMA-IR (r=0.461 and p=0.041. CONCLUSIONS: We conclude that low 25(OHD concentration was significantly associated with increased risk of insulin resistance. Since the adiponectin or hsCRP was not correlated, the possible pathways need to be futher investigated. KEYWORDS: central obesity, 25(OHD, adiponectin, hsCRP, insulin resistance (HOMA-IR.

  15. Investigating the Effect of Inflammation on Atrial Fibrillation Occurrence by Measuring Highly Sensitive C-reactive Protein (hs-CRP

    Directory of Open Access Journals (Sweden)

    Mahdi Hassanzadeh Delui

    2014-05-01

    Full Text Available Introduction: Atrial fibrillation (AF is the most prevalent cardiac arrhythmias that cardiologists and internists encounter. The goal of this article is to clarify an overview of the evidence linking inflammation to AF existence, which may highlight the effect of some pharmacological agents that have genuine potential to reduce the clinical burden of AF by modulating inflammatory pathways. Materials and Methods: In a case-control study, 50 patients with atrial fibrillation (AF with different etiologies and 50 patients with sinus rhythm and similar bases were selected. Sampling for highly sensitive c-reactive (hs-CRP was done on the patients presenting with AF to the Ghaem hospital between October 2006 and June 2007. Results: Mean age of the patients was 62 years with maximum of 90 and minimum of 36 and standard deviation of 13.80. The most frequent age group was 71-80years. Fifty-four percent of patients were male and 46% were female. Mean serum hs-CRP levels in AF patients with hypertension (HTN ,Ischemic heart disease(IHD, Valvular heart disease (VHD, HTN+IHD and hyperthyroidism were 8.10, 9.40, 8.68, 10.16 and 5.98 mg/Lit; respectively. There was significant difference between hs-CRP levels in hypertensive patients in the two groups (P=0.010. Similar results were observed in IHD patients, VHD patients and HTN+IHD patients in two groups (P=0.015, P=0.037, P=0.000. Conclusion: In addition to some risk factors like baseline cardiac diseases, aging, thyrotoxicosis, pulmonary embolism, pneumonia and cardiac surgery, there also appears to be consistent links between hs-CRP, a marker of inflammation, and the pathogenesis of AF.

  16. Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9.

    Science.gov (United States)

    Guo, Changlei; Zhang, Shaoli; Zhang, Junbiao; Liu, Hui; Li, Peicheng; Liu, Hengdao; Wang, Yakun

    2014-05-01

    The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (Phs-CRP and MMP-9, followed in descending order by those with UAP and SAP (Phs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (Phs-CRP and MMP-9 levels (r=-0.6634 and -0.6878, respectively; both Phs-CRP and MMP-9 levels correlated positively (r=0.7208, Phs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both Phs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.

  17. Determination of volatile aroma compounds of Ganoderma lucidum by gas chromatography mass spectrometry (HS-GC/MS).

    Science.gov (United States)

    Taşkın, Hatıra; Kafkas, Ebru; Çakıroğlu, Özgün; Büyükalaca, Saadet

    2013-01-01

    This study was conducted at Horticulture Department of Cukurova University, Adana, Turkey during 2010-2011. Fresh sample of Ganoderma lucidum collected from Mersin province of Turkey was used as material. Volatile aroma compounds were performed by Headspace Gas Chromatography (HS-GC/MS). Alcohols, aldehydes, acids, phenol, L-Alanine, d-Alanine, 3Methyl, 2-Butanamine, 2-Propanamine were determined. 1-Octen-3-ol (Alcohol) and 3-methyl butanal (Aldehyde) were identified as major aroma compounds.

  18. Non alcoholic fatty liver disease and its relationship with hsCRP in type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Naina Bhuyan

    2014-08-01

    Conclusions: High hsCRP is a cheap, easily available laboratory marker to suspect fatty liver and possibly steatohepatitis in T2 Diabetics in our region. It can identify a subgroup of diabetic patients in whom liver biopsy may be advisable to confirm steatohepatitis which is important for prognosis and therefore need aggressive intervention. [Int J Res Med Sci 2014; 2(4.000: 1586-1590

  19. The refinement of the surface layer of HS 7425 high speed tool steel by laser and electric arc plasma

    Directory of Open Access Journals (Sweden)

    W. Bochnowski

    2008-10-01

    Full Text Available The paper present two different techniques: laser remelting surface and plasma remelting surface of the high speed steel HS 7425. Thestructure of the remelted layers were examined by means of SEM – microscopy. Measurement of microhardness in remelting zone usingVickers method. The remelting zone consist of dendritic cells and columnar crystals. Increase of hardness was observed in remelted zonein comparison to the substrate of the steel. The hardness in the remelted zone increases with the increasing cooling rate.

  20. Euro on teel / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2005-01-01

    Reet Varblase kureeritud näitus "Oma raha" Tallinna Kunstihoone galeriis 12. XI-4. XII. Gints Gabransi videotest, Jaan Jaanisoo masin-installatsioonist, Siim-Tanel Annuse tööst. 2. XII galeriis toimunud kunstnike, kultuurihuviliste ja rahamaailma esindajate (Eesti Panga asepresident Rein Minka, endine president Vahur Kraft, rahandusministri nõuniku kt Veiko Valkiainen) kohtumisest

  1. Euro on teel / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2005-01-01

    Reet Varblase kureeritud näitus "Oma raha" Tallinna Kunstihoone galeriis 12. XI-4. XII. Gints Gabransi videotest, Jaan Jaanisoo masin-installatsioonist, Siim-Tanel Annuse tööst. 2. XII galeriis toimunud kunstnike, kultuurihuviliste ja rahamaailma esindajate (Eesti Panga asepresident Rein Minka, endine president Vahur Kraft, rahandusministri nõuniku kt Veiko Valkiainen) kohtumisest

  2. DIAGNOSTIC VALUE OF SIMULTANEOUS MEASUREMENT OF PROCALCITONIN, INTERLEUKIN-6 AND HS CRP IN PREDICTION OF EARLY-ONSET NEONATAL SEPSIS

    Directory of Open Access Journals (Sweden)

    alireza abdollahi

    2012-05-01

    Full Text Available Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations .We aimed to assess the value of simultaneous measurement of procalcitonin (PCT and interleukin-6 (IL-6 in association with high sensitive- C reactive protein in prediction of early neonatal sepsis. We performed a follow- up study on 95 neonates who were below 12 hours (h of age, had clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including “proven early-onset sepsis”, “clinical early-onset sepsis”, “negative infectious status”, and “uncertain infectious status”. Blood samples were obtained within the first 12 h of birth repeated between 24 hours and 36 hours of age for determination of serum levels of PCT, IL-6, high sensitivie- C Reactive Protein (hs-CRP, and white blood cell (WBC count. On admission, neonates with sepsis had a higher WBC count, IL-6, PCT, and hs-CRP levels compared with those neonates without sepsis. This remained significant even after 12-24 hours of admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL-6 within 12-24 hours after admission compared to the patients with uncertain sepsis. In final The combination of IL-6, hs-CRP, and PCT seems to be predictive in diagnosis of early onset neonatal sepsis.

  3. Scoring correction for MMPI-2 Hs scale with patients experiencing a traumatic brain injury: a test of measurement invariance.

    Science.gov (United States)

    Alkemade, Nathan; Bowden, Stephen C; Salzman, Louis

    2015-02-01

    It has been suggested that MMPI-2 scoring requires removal of some items when assessing patients after a traumatic brain injury (TBI). Gass (1991. MMPI-2 interpretation and closed head injury: A correction factor. Psychological assessment, 3, 27-31) proposed a correction procedure in line with the hypothesis that MMPI-2 endorsement may be affected by symptoms of TBI. This study assessed the validity of the Gass correction procedure. A sample of patients with a TBI (n = 242), and a random subset of the MMPI-2 normative sample (n = 1,786). The correction procedure implies a failure of measurement invariance across populations. This study examined measurement invariance of one of the MMPI-2 scales (Hs) that includes TBI correction items. A four-factor model of the MMPI-2 Hs items was defined. The factor model was found to meet the criteria for partial measurement invariance. Analysis of the change in sensitivity and specificity values implied by partial measurement invariance failed to indicate significant practical impact of partial invariance. Overall, the results support continued use of all Hs items to assess psychological well-being in patients with TBI. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. GmHs1-1, encoding a calcineurin-like protein, controls hard-seededness in soybean.

    Science.gov (United States)

    Sun, Lianjun; Miao, Zhenyan; Cai, Chunmei; Zhang, Dajian; Zhao, Meixia; Wu, Yanyan; Zhang, Xueling; Swarm, Stephen A; Zhou, Liwen; Zhang, Zhanyuan J; Nelson, Randall L; Ma, Jianxin

    2015-08-01

    Loss of seed-coat impermeability was essential in the domestication of many leguminous crops to promote the production of their highly nutritious seeds. Here we show that seed-coat impermeability in wild soybean is controlled by a single gene, GmHs1-1, which encodes a calcineurin-like metallophosphoesterase transmembrane protein. GmHs1-1 is primarily expressed in the Malpighian layer of the seed coat and is associated with calcium content. The transition from impermeability to permeability in domesticated soybean was caused by artificial selection of a point mutation in GmHs1-1. Interestingly, a number of soybean landraces evaded selection for permeability because of an alternative selection for seed-coat cracking that also enables seed imbibition. Despite the single origin of the mutant allele Gmhs1-1, the distribution pattern of allelic variants in the context of soybean population structure and the detected signature of genomic introgression between wild and cultivated soybeans suggest that Gmhs1-1 may have experienced reselection for seed-coat permeability.

  5. The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

    Science.gov (United States)

    Rivella, S; Callegari, J A; May, C; Tan, C W; Sadelain, M

    2000-05-01

    Retroviruses are highly susceptible to transcriptional silencing and position effects imparted by chromosomal sequences at their integration site. These phenomena hamper the use of recombinant retroviruses as stable gene delivery vectors. As insulators are able to block promoter-enhancer interactions and reduce position effects in some transgenic animals, we examined the effect of an insulator on the expression and structure of randomly integrated recombinant retroviruses. We used the cHS4 element, an insulator from the chicken beta-like globin gene cluster, which has been shown to reduce position effects in transgenic Drosophila. A large panel of mouse erythroleukemia cells that bear a single copy of integrated recombinant retroviruses was generated without using drug selection. We show that the cHS4 increases the probability that integrated proviruses will express and dramatically decreases the level of de novo methylation of the 5' long terminal repeat. These findings support a primary role of methylation in the silencing of retroviruses and suggest that cHS4 could be useful in gene therapy applications to overcome silencing of retroviral vectors.

  6. Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients

    Directory of Open Access Journals (Sweden)

    E.V. Adorno

    2008-02-01

    Full Text Available The fetal hemoglobin (HbF levels and ßS-globin gene haplotypes of 125 sickle cell anemia patients from Brazil were investigated. We sequenced the Gg- and Ag-globin gene promoters and the DNase I-2 hypersensitive sites in the locus control regions (HS2-LCR of patients with HbF level disparities as compared to their ßS haplotypes. Sixty-four (51.2% patients had CAR/Ben genotype; 36 (28.8% Ben/Ben; 18 (14.4% CAR/CAR; 2 (1.6% CAR/Atypical; 2 (1.6% Ben/Cam; 1 (0.8% CAR/Cam; 1 (0.8% CAR/Arab-Indian, and 1 (0.8% Sen/Atypical. The HS2-LCR sequence analyses demonstrated a c.-10.677G>A change in patients with the Ben haplotype and high HbF levels. The Gg gene promoter sequence analyses showed a c.-157T>C substitution shared by all patients, and a c.-222_-225del related to the Cam haplotype. These results identify new polymorphisms in the HS2-LCR and Gg-globin gene promoter. Further studies are required to determine the correlation between HbF synthesis and the clinical profile of sickle cell anemia patients.

  7. Analysis of the optical emission of the young precataclysmic variables HS 1857+5144 and ABELL 65

    Science.gov (United States)

    Shimansky, V. V.; Pozdnyakova, S. A.; Borisov, N. V.; Bikmaev, I. F.; Vlasyuk, V. V.; Spiridonova, O. I.; Galeev, A. I.; Mel'Nikov, S. S.

    2009-10-01

    We analyze the physical state and the properties of the close binary systems HS 1857+5144 and Abell 65. We took the spectra of both systems over a wide range of orbital phases with the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences (SAO RAS) and obtained their multicolor light curves with the RTT150 and Zeiss-1000 telescopes of the SAO RAS. We demonstrate that both Abell 65 and HS 1857+5144 are young precataclysmic variables (PV) with orbital periods of P orb = 1. d 003729 and P orb = 0. d 26633331, respectively. The observed brightness and spectral variations during the orbital period are due to the radiation of the cold component, which absorbs the short-wave radiation of the hot component and reemits it in the visual part of the spectrum. A joint analysis of the brightness and radial velocity curves allowed us to find the possible and optimum sets of their fundamental parameters. We found the luminosity excesses of the secondary components of HS 1857+5144 and Abell 65 with respect to the corresponding Main Sequence stars to be typical for such objects. The excess luminosities of the secondary components of all young PVs are indicative of their faster relaxation rate towards the quiescent state compared to the rates estimated in earlier studies.

  8. HS3D, A Dataset of Homo Sapiens Splice Regions, and its Extraction Procedure from a Major Public Database

    Science.gov (United States)

    Pollastro, Pasquale; Rampone, Salvatore

    The aim of this work is to describe a cleaning procedure of GenBank data, producing material to train and to assess the prediction accuracy of computational approaches for gene characterization. A procedure (GenBank2HS3D) has been defined, producing a dataset (HS3D - Homo Sapiens Splice Sites Dataset) of Homo Sapiens Splice regions extracted from GenBank (Rel.123 at this time). It selects, from the complete GenBank Primate Division, entries of Human Nuclear DNA according with several assessed criteria; then it extracts exons and introns from these entries (actually 4523 + 3802). Donor and acceptor sites are then extracted as windows of 140 nucleotides around each splice site (3799 + 3799). After discarding windows not including canonical GT-AG junctions (65 + 74), including insufficient data (not enough material for a 140 nucleotide window) (686 + 589), including not AGCT bases (29 + 30), and redundant (218 + 226), the remaining windows (2796 + 2880) are reported in the dataset. Finally, windows of false splice sites are selected by searching canonical GT-AG pairs in not splicing positions (271 937 + 332 296). The false sites in a range +/- 60 from a true splice site are marked as proximal. HS3D, release 1.2 at this time, is available at the Web server of the University of Sannio: http://www.sci.unisannio.it/docenti/rampone/.

  9. 急性脑梗死患者血清MMP-2、MMP-9和hs-CRP检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    王清峰

    2010-01-01

    目的 检测急性脑梗死(ACI)患者血清中基质金属蛋白酶-2(MMP-2)、MMP-9和超敏C反应蛋白(hs-CRP)的表达,探讨其临床意义.方法 选取102例ACI患者作为观察组,40例健康查体者作为对照组,检测两组血清MMP-2、MMP-9和hs-CRP水平.结果 观察组MMP-2、MMP-9和hs-CRP表达显著高于对照组,且随梗死范围的增大而升高(P<0.05);观察组MMP-9与hs-CRP的表达呈正相关(r=0.402,P<0.05). 结论 MMP-2、MMP-9和hs-CRP在ACI的发生发展中可能起重要作用;MMP-9和hs-CRP可能具有协同作用,早期联合检测MMP-2、MMP-9和hs-CRP有助于判断脑梗死病变程度.

  10. IMA、BNP和hsCRP在急性冠状动脉综合征早期诊断中的应用%Application of IMA,BNP and hsCRP in the diagnosis of early acute coronary syndromes

    Institute of Scientific and Technical Information of China (English)

    李宁; 刘丰海; 郭庆波; 陈增生; 杨元铭; 臧葳

    2015-01-01

    目的:探讨缺血修饰白蛋白(IMA)、B型尿钠肽(BNP)、超敏C反应蛋白(hsCRP)在急性冠脉综合征(ACS)早期诊断中的作用。方法来自青岛市立医院96例ACS患者作为治疗组,其中急性心肌梗死(AMI)42例,不稳定型心绞痛(UAP)54例,分别于胸痛发作2、4、6、12、18及24 h抽血,另选50名健康体检者作为对照组,两组均检测其IMA、BNP、hsCRP含量,评价这三项指标在ACS早期的应用价值。结果在急性冠状动脉综合征患者中IMA水平于胸痛发作2 h已明显增高,4 h仍持续增高,明显高于正常对照组(P<0.05),6 h降至正常。BNP、hsCRP水平于胸痛发作2 h显著升高,于12 h达到峰值。结论 IMA、BNP、hsCRP的表达与ACS密切相关,在ACS早期诊断中具有很高的应用价值。%Objective To investigate the application of ischemia modified albumin (IMA),B-type natriuretic peptide and hypersensitive C-reactive protein in early diagnosis of acute coronary syndromes(ACS). Methods The 96 cases of ACS from Qingdao Municipal hospital,including 42 cases of acute myocardial infarction(AMI),54 cases of unstable angina pectoris (UAP). Then their blood samples were collected at 2,4,6,12,18 and 24h after chest pain episode,50 healthy volunteers were as control;Detection of the content of IMA,BNP and hsCRP was done to give reasonable suggestions on the early diagnosis of ACS about them. Results At 2 hours after the onset of chest pain in patients with ACS,the level of IMA significantly increased;At 4 hours,it still increased and was significantly higher than that in control group until downing to normal at 6 hours. The BNP and hsCRP significantly increased at 2 hours,at 12 hours to reach peak. Conclusion The expression of IMA,BNP and hsCRP is closely related to ACS. It also has very high application value in the diagnosis of early ACS.

  11. The plastidic DEAD-box RNA helicase 22, HS3, is essential for plastid functions both in seed development and in seedling growth.

    Science.gov (United States)

    Kanai, Masatake; Hayashi, Makoto; Kondo, Maki; Nishimura, Mikio

    2013-09-01

    Plants accumulate large amounts of storage products in seeds to provide an energy reserve and to supply nutrients for germination and post-germinative growth. Arabidopsis thaliana belongs to the Brassica family, and oil is the main storage product in Arabidopsis seeds. To elucidate the regulatory mechanisms of oil biosynthesis in seeds, we screened for high density seeds (heavy seed) that have a low oil content. HS3 (heavy seed 3) encodes the DEAD-box RNA helicase 22 that is localized to plastids. The triacylglycerol (TAG) content of hs3-1 seeds was 10% lower than that of wild-type (WT) seeds, while the protein content was unchanged. The hs3-1 plants displayed a pale-green phenotype in developing seeds and seedlings, but not in adult leaves. The HS3 expression level was high in developing seeds and seedlings, but was low in stems, rosette leaves and flowers. The plastid gene expression profile of WT developing seeds and seedlings differed from that of hs3-1 developing seeds and seedlings. The expression of several genes was reduced in developing hs3-1 seeds, including accD, a gene that encodes the β subunit of carboxyltransferase, which is one component of acetyl-CoA carboxylase in plastids. In contrast, no differences were observed between the expression profiles of WT and hs3-1 rosette leaves. These results show that HS3 is essential for proper mRNA accumulation of plastid genes during seed development and seedling growth, and suggest that HS3 ensures seed oil biosynthesis by maintaining plastid mRNA levels.

  12. Application of SWAT-HS, a lumped hillslope model to simulate hydrology in the Cannonsville Reservoir watershed, New York

    Science.gov (United States)

    Hoang, Linh; Schneiderman, Elliot; Mukundan, Rajith; Moore, Karen; Owens, Emmet; Steenhuis, Tammo

    2017-04-01

    Surface runoff is the primary mechanism transporting substances such as sediments, agricultural chemicals, and pathogens to receiving waters. In order to predict runoff and pollutant fluxes, and to evaluate management practices, it is essential to accurately predict the areas generating surface runoff, which depend on the type of runoff: infiltration-excess runoff and saturation-excess runoff. The watershed of Cannonsville reservoir is part of the New York City water supply system that provides high quality drinking water to nine million people in New York City (NYC) and nearby communities. Previous research identified saturation-excess runoff as the dominant runoff mechanism in this region. The Soil and Water Assessment Tool (SWAT) is a promising tool to simulate the NYC watershed given its broad application and good performance in many watersheds with different scales worldwide, for its ability to model water quality responses, and to evaluate the effect of management practices on water quality at the watershed scale. However, SWAT predicts runoff based mainly on soil and land use characteristics, and implicitly considers only infiltration-excess runoff. Therefore, we developed a modified version of SWAT, referred to as SWAT-Hillslope (SWAT-HS), which explicitly simulates saturation-excess runoff by redefining Hydrological Response Units (HRUs) based on wetness classes with varying soil water storage capacities, and by introducing a surface aquifer with the ability to route interflow from "drier" to "wetter" wetness classes. SWAT-HS was first tested at Town Brook, a 37 km2 headwater watershed draining to the Cannonsville reservoir using a single sub-basin for the whole watershed. SWAT-HS performed well, and predicted streamflow yielded Nash-Sutcliffe Efficiencies of 0.68 and 0.87 at the daily and monthly time steps, respectively. More importantly, it predicted the spatial distribution of saturated areas accurately. Based on the good performance in the Town Brook

  13. Relationship between hs-CRP, proMMP-1, TIMP-1 and coronary plaque morphology: intravascular ultrasound study

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xing-wei; ZHOU Liang; YE Xian-hua; XU Jian; GE Jun-bo; YANG Jian-min; GE Lei; WANG Ning-fu; GAO Yan; LI Pei-zhang; PAN Hao; TONG Guo-xin

    2006-01-01

    Background Rupture of unstable plaque with subsequent thrombus formation is the common pathophysiological substrate of the acute coronary syndrome (ACS). It is of potential significance to explore the blood indexes predicting plaque characteristics. Little studies have focused on this field. Therefore we investigated the relationship between hypersensitive C-reactive protein (hs-CRP), pro-matrix metalloproteinase-1 (proMMP-1),tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) and coronary plaque morphology.Methods Intravascular ultrasound (IVUS) examination was done in 152 patients with confirmed coronary heart disease before percutaneous coronary intervention from February 2003 to July 2005. Plasma samples of arterial blood were collected prior to the procedure. The level of hs-CRP, proMMP-1 and TIMP-1 were respectively measured by enzyme-linked immunosorbent assay (ELISA).Results Unstable and ruptured plaque were found more frequently in patients with acute myocardial infarction and unstable angina. External elastic membrane cross-sectional area (EEM CSA), plaque area, lipid pool area and plaque burden were significantly larger in ruptured and unstable plaque group. Positive remolding, thinner frequent in ruptured and unstable plaque group. The levels of plasma hs-CRP, proMMP-1 and TIMP-1 were higher in ruptured plaque group. hs-CRP>8.94 mg/L was used to predict ruptured plaque with a ROC curve area of 0.76 [95% confidence interval (CI), 67.0%-85.8%], sensitivity of 71.8%, specificity of 77.0% and accuracy of 69.2% (P<0.01), similarly for proMMP-1>0.12 ng/ml with a ROC curve area of 0.69 [95% CI, 58.2%-80.2%], sensitivity of 69.2%, specificity of 75.2% and accuracy of 66.2% (P<0.01), and TIMP-1>83.45 ng/ml with a ROC curve area of 0.67 [95% CI, 56.2%-78.3%], sensitivity of 66.7%, specificity of 61.9% and accuracy of 66.2% (P<0.01).Conclusion The plaque characteristics correlate with the clinical presentation. The elevation of hs-CRP,proMMP-1 and

  14. 血清HS-CRP LDL-C/HDL-C在冠心病中的临床意义

    Institute of Scientific and Technical Information of China (English)

    徐文星; 蒋廷波

    2013-01-01

      目的通过检测冠心病(CHD)患者体内超敏C-反应蛋白(hs-CRP)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平,研究HS-CRP与LDL-C/HDL-C冠心病及冠心病病变程度中的临床意义.方法根据冠状动脉(简称冠脉)造影结果的Gensini评分,将患者分为四组:(1)冠脉造影正常组(64例):Gensini评分0分.(2)冠脉轻度病变组(61例):Gensini评分30分.比较四组hS-CRP及LDL-C/HDL-C升高与冠心病的相关程度.结果冠心病组患者的hs-CRP浓度和LDL-C/HDL-C均显著高于冠脉正常组(P30),the forth group:the normal group(=0),and Measured their hs-CRP,LDL-C/HDL-C.Results The serum hs-CRP levels and LDL-C/HDL-C in patients with coronary heart disease were significantly increased than those in normal group(P<0.05).In addition,hS - CRP levels in coronary artery coronary moderate lesion group is significantly higher than mild coronary artery lesion group(P<0.05);Severe lesion group is significantly higher than coronary moderate lesion group(P<0.05).Conclusion hS-CRP and LDL-C/HDL-C and coronary artery lesions are closely related,and hS-CRP is associated with the severity of the disease(according to the Gensini score),which can be used as to coronary artery lesion degree of estimation index.Although the serum levels of LDL-C/HDL-C are closely related to coronary artery lesions, it is hard to predict the degree of pathological changes fully accordingly to the such index.

  15. Locus control region HS2 point mutations are generally not responsible for elevated fetal hemoglobin expression of sickle cell patients

    Energy Technology Data Exchange (ETDEWEB)

    Gilman, J.G. [Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY (United States); Brinson, E.C.; Milner, P.M. [Medical College of Georgia, Augusta (United States)] [and others

    1994-09-01

    The locus control region (LCR), composed of four hypersensitive sites (HS1-4) 5{prime} of the {epsilon} globin gene, confers strong, copy-number dependent expression on globin genes in transgenic mice. Several {beta}-globin gene cluster haplotypes carry the sickle cell gene, and show variable levels of fetal hemoglobin (Hb F) expression in association with DNA sequence differences in HS2, {gamma} and {beta} globin promoters, and {gamma}IVSII: The Senegal (SEN or No. 3) haplotype generally has high (>10%) Hb F, Benin (BEN or No. 19) has intermediate Hb F (but some low and some high), and Banu (BAN or No. 20) generally has low Hb F. Huisman and colleagues have proposed that `factors produced under conditions of hematopoietic stress, together with genetic determinants on the haplotype-3 like LCR sequences, allow for high level expression of {gamma} globin genes`. We have now used slot blot to screen high Hb F (>9.5%) and low Hb F cases for two of the three HS2 point mutations described by Oener et al. Comparing eight high Hb F BEN/BEN with two low Hb F BEN/BEN, all ten had the BEN mutations considered by Oener et al. to be associated with low Hb F. Comparing three high Hb F BEN/BAN with two low Hb F BEN/BAN, all five were heterozygous at three positions; this is consistent with BEN having G and T and BAN having A at both positions. DNA sequencing of HS2 for BAN, which is generally associated with low HB F, showed that the point mutations at all three positions were those seen in SEN (generally high Hb F); only the AT repeat region showed major differences, confirming results of Huisman and colleagues. Hence, if there is any effect of HS2 of the Senegal sickle cell haplotype in causing elevated Hb F under hematopoietic stress, it must be due to specific variation in the AT repeat region, which Oener et al. have suggested may bind a silencer.

  16. Significance of IL-17 and hs-CRP detected in patients with acute aoronary syndrome%IL-17、hs-CRP联合检测在急性冠脉综合征中的意义

    Institute of Scientific and Technical Information of China (English)

    韦德宇; 丁晓梅; 苏浩; 胡昊; 陈东

    2011-01-01

    Aim To observe the changes of IL-17 and hs-CRP in patients with acute coronary syndrome (ACS) ,and whether there was correlation between the two or not,and to investigate the relationship between IL-17 and the instability of plaque. Methods 113 patients were divided into 4 groups:40 cases with acute myocardial infarction (AMI) ,31 cases with unstable angina (UA) ,18 patients with sta ble angina pectoris (SAP) ,and 24 patients with chest pain syndrome (CPS). All were taken blood from immediately after admission in, and centrifugal samples stored in -80℃ refrigerator to detect the serum levels of IL-17,hs-CRP,cTNI,CK-MB by ELISA. Results AMI and UA in peripheral blood levels of IL-17 [ (37.04 ± 9.92) , (30.11 ± 5.67) ng · L -1 ] were significantly higher than the SAP (20.95 ± 5.08) ng · L -1 and the CPS ( 15.81 ± 7.65) ng · L -1 (P < 0.01). Levels of hs-CRP in AMI and UA [ (39.21 ± 14.42), ( 11.57 ± 3.71) mg · L -1 ] ,were significantly higher than the SAP (3.53 ± 4.45) mg · L -1 and the CPS gr(2.94 ± 3.97) mg · L -1 (P < 0.05). IL-17 and hs-CRP were positively correlated(r 0. 364,P < 0. 001). Conclusion The serum levels of IL-17 were significantly increased and was positively correlated with hs-CRP. We suggested that IL-17 becorrelated with the instability of atheroscle rotic plaque,and also involved in the pathogenesis of ACS.%目的 观察IL-17、hs-CRP在急性冠脉综合征(ACS)患者血清中的水平变化,同时观察两者是否存在相关性,推测IL-17与斑块不稳定性的关系.方法 选择113例患者分为四组:急性心肌梗死(AMI)40例,不稳定型心绞痛(UA)31例,稳定型心绞痛(SAP)18例,胸痛综合征(CPS)24例.患者入院后立即留取静脉血标本离心,存于-80℃的冰箱,采用ELISA法集中检测患者血清中的IL-17、hs-CRP、cTNI、CK-MB水平.结果 AMI组和UA组外周血清IL-17水平分别为(37.04±9.92)、(30.11±5.67)ng·L-1,明显高于SAP组的(20.95±5.08)ng·L-1和CPS组(15.81±7.65)ng

  17. Periodontal Status in Patients with Coronary Heart Disease and Fg and hs-CRP Correlation.%冠心病患者的牙周状况与Fg和hs-CRP相关性的研究

    Institute of Scientific and Technical Information of China (English)

    钟慧敏; 常春荣; 张建全; 俞宁; 潘亚萍

    2011-01-01

    目的:通过牙周临床检查和血生化指标检测,观察冠心病患者的牙周状况,探讨纤维蛋白原和高敏C反应蛋白在两者间的相关关系.方法:按照冠心病及慢性牙周炎临床诊断标准随机选择200名研究对象,年龄35~80岁,分为急性冠脉综合征(ACS)组50人,慢性冠脉病(CAD)组50人,单纯慢性牙周炎(CP)组50人,健康(H)对照组50人,每组都进行牙周探诊深度(PD)、临床附着丧失度(CAL)、龈沟出血指数(SBI)和简化卫生指数(OHI-S)检查,采集清晨静脉血检测Fg和hs-CRP水平.结果:PD、CAL、OHI-S在ACS组中最高,与CP组比较有显著性差异(P<0.001);SBI在CAD组中最高,ACS组与CP组比较有显著性差异(P<0.001);Fg和hs-CRP在ACS组中测定值最高,与CP组比较有显著性差异(P<0.05);血生化指标Fg和hs-CRP的水平与牙周临床指标PD、CAL、SBI、OHI-S比较呈正相关(P<0.01).结论:冠心病患者无论是急性期还是稳定期牙周状况都比单纯慢性牙周炎患者严重;PD、CAL、OHI-S的升高可引起血清中Fg和hs-CRP水平的变化,牙周临床指标的改变可能与冠心病的急性发作和加重冠心病病程有关.%Objective: To observe the periodontal condition in patients with coronary heart disease and relationship between hs-CRP and Fg by periodontal clinical examination and serum biochemical parameters.Methods: The selected 200 subjects were aged 35-89 years old.A group of acute coronary syndrome was 50 persons.A group of chronic coronary artery disease was 50 persons.A group of simple chronic periodonititis was 50 persons.A healthy control group was 50 persons.Each group was checked probing depth (PD), clinical attachment loss degrees (CAL), gingival sulcus bleeding index (SBI) and simplified health index (OHI-S).They were also collected blood in the morning to test the levels of hs-CRP and Fg, compared the levels of periodontal clinical parameters and difference between Fg and hs-CRP.Results: PD, CAL, OHI

  18. External Causes to Tashi's Self Realization from Jung's Archetypal Theory%从非我到自我--荣格原型理论视角下塔希自我实现外因探析

    Institute of Scientific and Technical Information of China (English)

    杨波; 阮明月

    2016-01-01

    Jung's Archetypal Theory put forward in the 20th century has had huge impact on social sciences. American black female writer Alice Walker and her Possessing the Secret of Joy have been pro-foundly affected by Jung, which describes the growing process of the protagonist Tashi after receiving tribal genital circumcision. Based on Jung's Archetypal Theory, Tashi's self awakening should be attributed to the enlightenment, guidance and assistance of a few essential characters in the novel. For instance, the power of shadow embodied in M'Lissa who practices circumcision, the image of wise man reflected in the psy-choanalysts Carl and Raye, and the self archetype in androgynous Pierre. They have worked together to lead her to fulfill her self wholeness and achieve harmony eventually.%荣格博士于20世纪提出的原型理论对人文科学产生了巨大影响,美国黑人女作家艾丽斯·沃克代表作《拥有快乐的秘密》的创作深受其原型理论影响。作品讲述了女主人公塔希在惨遭部落割礼迫害后寻求自我完整的成长历程,依据荣格原型理论,塔希的觉醒与自我实现离不开小说中其他角色的启发、引导与帮助:行割礼者穆丽莎呈现出阴影的力量,提供了令塔希警醒的反面范式;心理分析师卡尔和莱伊代表了智者的形象,对塔西循循善诱;具有双性同体特质的皮埃尔展现出完整的自性原型,他们指引塔希从对抗最终走向了和谐。

  19. 新核素~(263)Hs,~(260)Bh及其α衰变链上核素的半衰期%Half-lives of the newly synthesized nuclei in ~(263)Hs and ~(260)Bh α-decay chains

    Institute of Scientific and Technical Information of China (English)

    苏昕宁; 张鸿飞; 左维; 李君清

    2009-01-01

    The tunneling probability of potential barrier of the newly synthesized superheavy nuclei starting from ~(263)Hs and ~(260)Bh was calculated with the Generalized Liquid Drop Model (GLDM) connected with WKB approximation and their half-lives studied. The calculated results that are in agreement with the experimental data show that the α-decay half-lives of superheavy nuclei with the Generalized Liquid Drop Model connecting with WKB approximation can be successfully, applied in the study of superheavy nuclei and describe the α-decay of superheavy nuclei. The results also indicate that the syntheses of new nuclei ~(260)Bh and ~(263)Hs and the measurements of their α-decay half-lives are reliable.%运用推广的液滴模型(GLDM)并结合量子力学中的WKB方法计算了新核素~(263)Hs,~(260)Bh及其α衰变链上各核素的势垒贯穿概率,对该链上各原子核的α衰变半衰期进行了研究.计算结果表明:利用推广的液滴模型结合WKB方法计算出的α衰变半衰期可以很好地符合在超重核区的实验值,验证了推广的液滴模型在超重核区的适用性,能够很好地描述超重核的α衰变.同时,计算表明新核素~(260)Bh和~(263)Hs的合成及其半衰期的测量是可靠的.

  20. Hs-exosomes致敏树突状细胞介导的抗卵巢癌免疫治疗的实验研究

    Institute of Scientific and Technical Information of China (English)

    张峰琴

    2012-01-01

    目的检测卵巢癌细胞的外排小体Hs-exosomes致敏树突状细胞DC诱导T淋巴细胞CTL特异性杀伤卵巢癌细胞的能力。方法:分离卵巢癌细胞株2780释放的Hs-exosomes,将其致敏DC并与T淋巴细胞共培养,检测CTL体外细胞毒活性。结果:Hs-exosomes致敏DC激活CTL的抗肿瘤能力显著高于未致敏DC组。结论:2780细胞释放的Hs-exosomes致敏DC激活T淋巴细胞对肿瘤具有很强的杀伤作用。

  1. Transitioning high sensitivity cardiac troponin I (hs-cTnI) into routine diagnostic use: More than just a sensitivity issue

    LENUS (Irish Health Repository)

    Lee, Graham R

    2016-04-01

    High sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI) assays show analytical, diagnostic and prognostic improvement over contemporary sensitive cTn assays. However, given the importance of troponin in the diagnosis of myocardial infarction, implementing this test requires rigorous analytical and clinical verification across the total testing pathway. This was the aim of this study.

  2. A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive protein (hsCRP) as a marker for insulin resistance.

    LENUS (Irish Health Repository)

    O'Sullivan, Eoin P

    2013-01-01

    Insulin resistance (IR) is associated with low adiponectin and elevated high sensitivity C-reactive protein (hsCRP). Osteoprotegerin (OPG) has been shown to be elevated in type 2 diabetes, but whether it reflects underlying IR is unclear. We aimed to compare the ability of serum OPG with adiponectin and hsCRP to act as a marker for IR in individuals with normal and abnormal glucose tolerance.

  3. Kinetics and time dependence of the differential agglutination of acetone [AC]- and formalin [HS]-fixed Toxoplasma tachyzoites by serum of mice with experimental toxoplasmosis.

    Science.gov (United States)

    Ali, Nehad Mahmoud; Habib, Khaled Sayed Mohamed

    2012-04-01

    Researches to specify a serologic diagnostic test capable of determining the stage of toxoplasmosis, whether recent or latent, have been hampered by lack of knowing the real time of infection. Studying the precise kinetics of the differential agglutination of acetone [AC]-fixed versus that of formalin [HS]-fixed tachyzoites (differential agglutination test or AC/HS test) by sera of mice during the course of toxoplasmosis and assessment of its value in the differentiation between recent and latent infections in mice were the aims of the present work. Experimental toxoplasmosis was induced in mice, sera were collected sequentially and AC/HS test, FAST-ELISA to determine levels of IgM and IgG and microscopic examination of brain for Toxoplasma cysts were done. Both AC and HS specific patterns in the AC/HS test were noted to be dependent on the time from the onset of infection. Acute patterns of the AC/HS test were observed early in infection till before the appearance of brain cysts. Non-acute patterns were obtained late on 28th day post infection coinciding with the disappearance of IgM, persistence of IgG and presence of cysts in brains. The AC antibody was high in the recent phase of infection, and then it declined to be replaced by high sustained level of HS antibody late in infection. In conclusion, in the presence of both IgM and IgG, the appearance of either equivocal pattern or the non-acute pattern in the AC/HS test is significant in ruling out acute infection in mice.

  4. Interference of Co-Amplified Nuclear Mitochondrial DNA Sequences on the Determination of Human mtDNA Heteroplasmy by Using the SURVEYOR Nuclease and the WAVE HS System

    OpenAIRE

    Hsiu-Chuan Yen; Shiue-Li Li; Wei-Chien Hsu; Petrus Tang

    2014-01-01

    High-sensitivity and high-throughput mutation detection techniques are useful for screening the homoplasmy or heteroplasmy status of mitochondrial DNA (mtDNA), but might be susceptible to interference from nuclear mitochondrial DNA sequences (NUMTs) co-amplified during polymerase chain reaction (PCR). In this study, we first evaluated the platform of SURVEYOR Nuclease digestion of heteroduplexed DNA followed by the detection of cleaved DNA by using the WAVE HS System (SN/WAVE-HS) for detectin...

  5. Mitochondrial HMG to CoA synthase (mHS): cDNA cloning in human, mouse and C. elegans, mapping to human chromosome 1p12-13 and partial human genomic cloning

    Energy Technology Data Exchange (ETDEWEB)

    Boukaftane, Y.; Robert, M.F.; Mitchell, G.A. [Hopital Sainte-Justine, Montreal, Quebec (Canada)]|[Kingston General Hospital, Ontario (Canada)] [and others

    1994-09-01

    mHS catalyzes the rate-limiting first step of ketogenesis in the liver. A cytoplasmic HS isozyme, encoded by another gene, catalyzes an early step in cholesterol synthesis. Starting from a rat mHS cDNA obtained by RT-PCR from the published rat cDNA sequence, we obtained and sequenced human and mouse cDNAs spanning the entire coding sequence of natural human and mouse mHS, as well as sequencing C. elegans HS-like cDNA. Consensus sequences for 3 mitochondrial and 4 cytoplasmic HSs were created and compared to invertebrate HS sequences. We found high conversation in the active site and at other regions presumably important for HS function. We mapped the mHS locus, HMGCS2 by in situ hybridization to chromosome 1P12-13, in contrast to the human cHS locus (HMGCS1) known to be on chromosome 5p13. Comparative mapping results suggest that these two chromosomal regions may be contiguous in other species, constant with a recent gene duplication event. Furthermore, we have characterized a human genomic mHS subclone containing 4 mHS exons, and found the position of all splice junctions to be identical to that of the hamster cHS gene except for one site in the 3{prime} nontranslated region. We calculate that the mHS and cHS genes were derived from a common ancestor 400-700 Myrs ago, implying that ketogenesis from fat may have become possible around the time of emergence of vertebrates ({approximately}500 Myr ago). Ketogenesis has evolved into an important pathway of energy metabolism, and we predict the mHS deficiency may prove to be responsible for some as yet explained cases of Reye-like syndromes in humans. This hypothesis can now be tested at the molecular level without the necessity of obtaining hepatic tissue.

  6. Galectin 1 Proangiogenic and Promigratory Effects in the Hs683 Oligodendroglioma Model Are Partly Mediated through the Control of BEX2 Expression

    Directory of Open Access Journals (Sweden)

    Marie Le Mercier

    2009-05-01

    Full Text Available We have previously reported that galectin 1 (Gal-1 plays important biological roles in astroglial as well as in oligodendroglial cancer cells. As an oligodendroglioma model, we make use of the Hs683 cell line that has been previously extensively characterized at cell biology, molecular biology, and genetic levels. Galectin 1 has been shown to be involved in Hs683 oligodendroglioma chemoresistance, neoangiogenesis, and migration. Down-regulating Gal-1 expression in Hs683 cells through targeted small interfering RNA provokes a marked decrease in the expression of the brain-expressed X-linked gene: BEX2. Accordingly, the potential role of BEX2 in Hs683 oligodendroglioma cell biology has been investigated. The data presented here reveal that decreasing BEX2 expression in Hs683 cells increases the survival of Hs683 orthotopic xenograft-bearing mice. Furthermore, this decrease in BEX2 expression impairs vasculogenic mimicry channel formation in vitro and angiogenesis in vivo, and modulates glioma cell adhesion and invasive features through the modification of several genes previously reported to play a role in cancer cell migration, including MAP2, plexin C1, SWAP70, and integrin β6. We thus conclude that BEX2 is implicated in oligodendroglioma biology.

  7. Galectin 1 Proangiogenic and Promigratory Effects in the Hs683 Oligodendroglioma Model Are Partly Mediated through the Control of BEX2 Expression1

    Science.gov (United States)

    Mercier, Marie Le; Fortin, Shannon; Mathieu, Véronique; Roland, Isabelle; Spiegl-Kreinecker, Sabine; Haibe-Kains, Benjamin; Bontempi, Gianluca; Decaestecker, Christine; Berger, Walter; Lefranc, Florence; Kiss, Robert

    2009-01-01

    We have previously reported that galectin 1 (Gal-1) plays important biological roles in astroglial as well as in oligodendroglial cancer cells. As an oligodendroglioma model, we make use of the Hs683 cell line that has been previously extensively characterized at cell biology, molecular biology, and genetic levels. Galectin 1 has been shown to be involved in Hs683 oligodendroglioma chemoresistance, neoangiogenesis, and migration. Down-regulating Gal-1 expression in Hs683 cells through targeted small interfering RNA provokes a marked decrease in the expression of the brain-expressed X-linked gene: BEX2. Accordingly, the potential role of BEX2 in Hs683 oligodendroglioma cell biology has been investigated. The data presented here reveal that decreasing BEX2 expression in Hs683 cells increases the survival of Hs683 orthotopic xenograft-bearing mice. Furthermore, this decrease in BEX2 expression impairs vasculogenic mimicry channel formation in vitro and angiogenesis in vivo, and modulates glioma cell adhesion and invasive features through the modification of several genes previously reported to play a role in cancer cell migration, including MAP2, plexin C1, SWAP70, and integrin β6. We thus conclude that BEX2 is implicated in oligodendroglioma biology. PMID:19412433

  8. Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression.

    Science.gov (United States)

    Le Mercier, Marie; Fortin, Shannon; Mathieu, Véronique; Roland, Isabelle; Spiegl-Kreinecker, Sabine; Haibe-Kains, Benjamin; Bontempi, Gianluca; Decaestecker, Christine; Berger, Walter; Lefranc, Florence; Kiss, Robert

    2009-05-01

    We have previously reported that galectin 1 (Gal-1) plays important biological roles in astroglial as well as in oligodendroglial cancer cells. As an oligodendroglioma model, we make use of the Hs683 cell line that has been previously extensively characterized at cell biology, molecular biology, and genetic levels. Galectin 1 has been shown to be involved in Hs683 oligodendroglioma chemoresistance, neoangiogenesis, and migration. Down-regulating Gal-1 expression in Hs683 cells through targeted small interfering RNA provokes a marked decrease in the expression of the brain-expressed X-linked gene: BEX2. Accordingly, the potential role of BEX2 in Hs683 oligodendroglioma cell biology has been investigated. The data presented here reveal that decreasing BEX2 expression in Hs683 cells increases the survival of Hs683 orthotopic xenograft-bearing mice. Furthermore, this decrease in BEX2 expression impairs vasculogenic mimicry channel formation in vitro and angiogenesis in vivo, and modulates glioma cell adhesion and invasive features through the modification of several genes previously reported to play a role in cancer cell migration, including MAP2, plexin C1, SWAP70, and integrin beta(6). We thus conclude that BEX2 is implicated in oligodendroglioma biology.

  9. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

    Science.gov (United States)

    Rashid, M. Harunur; Huq, Redwan; Tanner, Mark R.; Chhabra, Sandeep; Khoo, Keith K.; Estrada, Rosendo; Dhawan, Vikas; Chauhan, Satendra; Pennington, Michael W.; Beeton, Christine; Kuyucak, Serdar; Norton, Raymond S.

    2014-03-01

    HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu substitution at position 14. Complexes of HsTX1 with the voltage-gated potassium channels Kv1.3 and Kv1.1 were created using docking and molecular dynamics simulations, then umbrella sampling simulations were performed to construct the potential of mean force (PMF) of the ligand and calculate the corresponding binding free energy for the most stable configuration. The PMF method predicted that the R14A mutation in HsTX1 would yield a > 2 kcal/mol gain for the Kv1.3/Kv1.1 selectivity free energy relative to the wild-type peptide. Functional assays confirmed the predicted selectivity gain for HsTX1[R14A] and HsTX1[R14Abu], with an affinity for Kv1.3 in the low picomolar range and a selectivity of more than 2,000-fold for Kv1.3 over Kv1.1. This remarkable potency and selectivity for Kv1.3, which is significantly up-regulated in activated effector memory cells in humans, suggest that these analogues represent valuable leads in the development of therapeutics for autoimmune diseases.

  10. Apoferritin-templated biosynthesis of manganese nanoparticles and investigation of direct electron transfer of MnNPs-HsAFr at modified glassy carbon electrode.

    Science.gov (United States)

    Rafipour, Ronak; Kashanian, Soheila; Hashemi, Sadegh; Omidfar, Kobra; Ezzati Nazhad Dolatabadi, Jafar

    2017-01-01

    Manganese nanoparticles (MnNPs) were created within horse spleen apoferritin (HsAFr) cavity nanotemplates. Transmission electron microscopy revealed the particle size to be 6 nm. Intrinsic fluorescence data showed that the mineralization acted as a quencher of the HsAFr fluorescence, and extrinsic fluorescence data revealed that the hydrophobic binding site at the surface of HsAFr was not changed. Finally, the MnNP-HsAFr was immobilized onto multiwalled carbon nanotubes entrapped into chitosan (CS) matrices by through sequential 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-N-hydroxysuccinimide and glutaraldehyde coupling. The MnNPs-HsAFr immobilized on CNT-CS/GC electrode was characterized by cyclic voltammetry. This charge transfer coefficient (α) and the exchange current (i0 ) of MnNPs-HsAFr immobilized on modified electrode in 0.1 M phosphate solution (pH 7.5) were found to be 0.57 and 0.48 μA, respectively. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

  11. hs-CRP检测在儿童感染性疾病诊断中的临床应用价值

    Institute of Scientific and Technical Information of China (English)

    邹尚敏

    2014-01-01

    目的:探讨超敏C反应蛋白(HS-CRP)对儿童感染性疾病的诊断意义.方法:选择215例感染性疾病患儿,其中细菌感染组112例,病毒感染组103例,检测两组患儿血清中hs-CRP浓度.结果:病毒感染组hs-CRP值平均为(3.47±2.15)mg/L,细菌感染组hs-CRP平均值为(44.74±12.83)mg/L,两组患儿hs-CRP浓度比较有统计学差异(P<0.01).结论:hs-CRP检测可迅速对细菌感染和病毒感染做出判断,可作为诊断和鉴别诊断儿科感染性疾病的有效指标.

  12. Accurate double many-body expansion potential energy surface of HS2A2A‧) by scaling the external correlation

    Science.gov (United States)

    Lu-Lu, Zhang; Yu-Zhi, Song; Shou-Bao, Gao; Yuan, Zhang; Qing-Tian, Meng

    2016-05-01

    A globally accurate single-sheeted double many-body expansion potential energy surface is reported for the first excited state of HS2 by fitting the accurate ab initio energies, which are calculated at the multireference configuration interaction level with the aug-cc-pVQZ basis set. By using the double many-body expansion-scaled external correlation method, such calculated ab initio energies are then slightly corrected by scaling their dynamical correlation. A grid of 2767 ab initio energies is used in the least-square fitting procedure with the total root-mean square deviation being 1.406 kcal·mol-1. The topographical features of the HS2(A2A‧) global potential energy surface are examined in detail. The attributes of the stationary points are presented and compared with the corresponding ab initio results as well as experimental and other theoretical data, showing good agreement. The resulting potential energy surface of HS2(A2A‧) can be used as a building block for constructing the global potential energy surfaces of larger S/H molecular systems and recommended for dynamic studies on the title molecular system. Project supported by the National Natural Science Foundation of China (Grant No. 11304185), the Taishan Scholar Project of Shandong Province, China, the Shandong Provincial Natural Science Foundation, China (Grant No. ZR2014AM022), the Shandong Province Higher Educational Science and Technology Program, China (Grant No. J15LJ03), the China Postdoctoral Science Foundation (Grant No. 2014M561957), and the Post-doctoral Innovation Project of Shandong Province, China (Grant No. 201402013).

  13. HS-SPME-GC×GC-qMS volatile metabolite profiling of Chrysolina herbacea frass and Mentha spp. leaves.

    Science.gov (United States)

    Cordero, Chiara; Zebelo, Simon Atsbaha; Gnavi, Giorgio; Griglione, Alessandra; Bicchi, Carlo; Maffei, Massimo E; Rubiolo, Patrizia

    2012-02-01

    Headspace solid-phase microextraction (HS-SPME) comprehensive two-dimensional (2D) gas chromatography combined with quadrupole-mass spectrometry (GC×GC-qMS) with dedicated comparative data elaboration was applied to separate chemical patterns arising from the interaction between some Mentha species and the herbivore Chrysolina herbacea, also known as the mint bug. Upon feeding on different Mentha species (Mentha spicata L., Mentha × piperita L. and Mentha longifolia L.), C. herbacea produced frass (faeces) which were characterized by a typical volatile fraction. HS-SPME GC×GC-qMS analysis of the complex volatile fraction of both mint leaf and C. herbacea frass was submitted to advanced fingerprinting analysis of 2D chromatographic data. 1,8-Cineole, found in the leaves of all the Mentha species examined, was oxidized, and C. herbacea frass yielded high rates of several hydroxy-1,8-cineoles, including 2α-hydroxy-, 3α-hydroxy-, 3β-hydroxy- and 9-hydroxy-1,8-cineole. Upon insect feeding, several unknown oxidized monoterpenes, a p-menthane diol and three unknown phenylpropanoids were also detected in the frass volatiles. In M. longifolia, the occurrence of the monoterpene piperitenone oxide was found to be toxic and associated with insect death. The results of this work show that high throughput techniques such as HS-SPME and GC×GC-qMS fingerprint analysis are ideal tools to analyze complex volatile matrices, and provide a sensitive method for the direct comparison and chemical visualization of plant and insect emitted volatile components.

  14. Spatial dose distributions in solid tumors from {sup 186}Re transported by liposomes using HS radiochromic media

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Luis A.; Rodriguez-Villafuerte, Mercedes; Martinez-Davalos, Arnulfo; Galvan, Olga O.; Brandan, Maria-Ester [Instituto de Fisica, UNAM, A.P. 20-364, Mexico (Mexico); Goins, Beth; Awasthi, Vibhudutta; Santoyo, Cristina; Phillips, William T. [University of Texas Health Science Center at San Antonio, Department of Radiology, San Antonio, TX (United States); Bao, Ande [University of Texas Health Science Center at San Antonio, Department of Radiology, San Antonio, TX (United States); University of Texas Health Science Center at San Antonio, Department of Otolaryngology-Head and Neck Surgery, San Antonio, TX (United States)

    2007-07-15

    A procedure for the measurement of spatial dose rate distribution of beta particles emitted by {sup 186}Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of {sup 186}Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4 C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a {sup 60}Co calibration curve, the {sup 186}Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h{sup -1} in tumors injected with 3.7 MBq and 1.3 Gy h{sup -1} in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95% and 80% of the tumor when injected with the lower and the higher activity, respectively. The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with {sup 186}Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements. (orig.)

  15. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges

    Directory of Open Access Journals (Sweden)

    McCormack Brendan

    2008-01-01

    Full Text Available Abstract Background The PARiHS framework (Promoting Action on Research Implementation in Health Services has proved to be a useful practical and conceptual heuristic for many researchers and practitioners in framing their research or knowledge translation endeavours. However, as a conceptual framework it still remains untested and therefore its contribution to the overall development and testing of theory in the field of implementation science is largely unquantified. Discussion This being the case, the paper provides an integrated summary of our conceptual and theoretical thinking so far and introduces a typology (derived from social policy analysis used to distinguish between the terms conceptual framework, theory and model – important definitional and conceptual issues in trying to refine theoretical and methodological approaches to knowledge translation. Secondly, the paper describes the next phase of our work, in particular concentrating on the conceptual thinking and mapping that has led to the generation of the hypothesis that the PARiHS framework is best utilised as a two-stage process: as a preliminary (diagnostic and evaluative measure of the elements and sub-elements of evidence (E and context (C, and then using the aggregated data from these measures to determine the most appropriate facilitation method. The exact nature of the intervention is thus determined by the specific actors in the specific context at a specific time and place. In the process of refining this next phase of our work, we have had to consider the wider issues around the use of theories to inform and shape our research activity; the ongoing challenges of developing robust and sensitive measures; facilitation as an intervention for getting research into practice; and finally to note how the current debates around evidence into practice are adopting wider notions that fit innovations more generally. Summary The paper concludes by suggesting that the future

  16. Ecodesign - How to Unfold the Potential Synergy between the EuP, WEEE and RoHS Directives

    DEFF Research Database (Denmark)

    Andersen, Rikke Dorothea; Remmen, Arne

    Product Policy (IPP). The approach aims at promoting measures to reduce the environmental impacts of products. Since the IPP approach was introduced around 2000, several instruments have been implemented; the RoHS, WEEE and the EuP Directive as well as the European ecolabel and the Energy labelling...... Directive. The focus of this paper is the potential synergy between the three normative, so-called eco-design directives, and to what extent the EU has accomplished to integrate eco-design in the different directives and voluntary instruments....

  17. A novel erythromycin resistance plasmid from Bacillus sp. strain HS24, isolated from the marine sponge Haliclona simulans.

    Directory of Open Access Journals (Sweden)

    Teresa M Barbosa

    Full Text Available A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine sponge Haliclona simulans. pBHS24B has a mosaic structure and carries the erythromycin resistance gene erm(T. This is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of the Erm(T determinant in the genus Bacillus.

  18. Heat perception and aversive learning in honey bees: putative involvement of the thermal/chemical sensor AmHsTRPA

    Directory of Open Access Journals (Sweden)

    Pierre eJunca

    2015-11-01

    Full Text Available The recent development of the olfactory conditioning of the sting extension response (SER has provided new insights into the mechanisms of aversive learning in honeybees. However, until now, very little information has been obtained concerning US detection and perception in this aversive conditioning. In the initial version of SER conditioning, bees learned to associate an odor CS with an electric shock US. Recently, we proposed a modified version of SER conditioning, in which thermal stimulation with a heated probe is used as US. This procedure has the advantage of allowing topical US applications virtually everywhere on the honeybee body. In this study, we made use of this possibility and mapped thermal responsiveness on the honeybee body, by measuring workers' SER after applying heat on 41 different structures. We then show that bees can learn the CS-US association even when the heat US is applied on body structures that are not prominent sensory organs, here the vertex (back of the head and the ventral abdomen. Next, we used a neuropharmalogical approach to evaluate the potential role of a recently described Transient Receptor Potential (TRP channel, HsTRPA, on peripheral heat detection by bees. First, we applied HsTRPA activators

  19. Quality changes during storage of cooked and sliced meat products measured with PTR-MS and HS-GC-MS.

    Science.gov (United States)

    Holm, E S; Adamsen, A P S; Feilberg, A; Schäfer, A; Løkke, M M; Petersen, M A

    2013-10-01

    The changes in the VOC composition of industrially produced saveloy were measured with Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) and HeadSpace Gas chromatography-mass spectrometry (HS-GC-MS) during a six weeks storage period. A decrease in the volatile organic compounds contributing to the fresh aroma of saveloy was the main change observed with both PTR-MS and HS-GC-MS. Samples of four other types of cooked and sliced meat product were measured with PTR-MS in the middle and at the end of the four week shelf-life period. These measurements showed an increase in m/z 69, 71, 87 and 89 for the pork loin and in m/z 61 for the herbal saveloy samples. These ions were assigned to the microbial spoilage markers: acetic acid, 2- and 3-methylbutanol, 2- and 3-methylbutanal, diacetyl and acetoin. Overall, this study shows that PTR-MS has potential for quality control of cooked and sliced meat products. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Volatile profile analysis and quality prediction of Longjing tea (Camellia sinensis) by HS-SPME/GC-MS

    Institute of Scientific and Technical Information of China (English)

    Jie LIN; Yi DAI; Ya-nan GUO; Hai-rong XU; Xiao-chang WANG

    2012-01-01

    This study aimed to analyze the volatile chemical profile of Longjing tea,and further develop a prediction model for aroma quality of Longjing tea based on potent odorants.A total of 21 Longjing samples were analyzed by headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS).Pearson's linear correlation analysis and partial least square (PLS) regression were applied to investigate the relationship between sensory aroma scores and the volatile compounds.Results showed that 60 volatile compounds could be commonly detected in this famous green tea.Terpenes and esters were two major groups characterized,representing 33.89% and 15.53% of the total peak area respectively.Ten compounds were determined to contribute significantly to the perceived aroma quality of Longjing tea,especially linalool (0.701),nonanal (0.738),(Z)-3-hexenyl hexanoate (-0.785),and β-ionone (-0.763).On the basis of these 10 compounds,a model (correlation coefficient of 89.4% and cross-validated correlation coefficient of 80.4%) was constructed to predict the aroma quality of Longjing tea.Summarily,this study has provided a novel option for quality prediction of green tea based on HS-SPME/GC-MS technique.

  1. Degradation of phenanthrene by Novosphingobium sp. HS2a improved plant growth in PAHs-contaminated environments.

    Science.gov (United States)

    Rodriguez-Conde, Sara; Molina, Lázaro; González, Paola; García-Puente, Alicia; Segura, Ana

    2016-12-01

    At the same time that the European Union (EU) policy recommend to direct efforts towards reductions of heavy metals, polycyclic aromatic hydrocarbons (PAHs) and mining residues, there is the need to increase the cultivable areas within Europe to cope with the increasing demands for food and energy crops. Bioremediation is a good technique for the restoration of contaminated soils; however, it has not been used extensively because of the variability of the outcome. This variability is frequently due to a bad establishment of foreign degrading populations in soil. We have demonstrated that Novosphingobium sp. HS2aR (i) is able to compete with other root colonizers and with indigenous bacteria, (ii) is able to establish in high numbers in the contaminated environments and (iii) is able to remove more than 90 % of the extractable phenanthrene in artificially contaminated soils. Furthermore, we have demonstrated that the capacity to remove phenanthrene is linked to the ability to promote plant growth in contaminated environments. The fact that the presence of Novosphingobium sp. HS2aR improves the growth of plants in contaminated soil suggests that it may be a useful strain for utilization in amelioration of soil quality while improving the growth of economically important energy crops, thus adding value to the bioremediation strategy.

  2. Effect of hs-CRP level and nutritional status on pulmonary function in patients with maintenance hemodialysis

    Institute of Scientific and Technical Information of China (English)

    Ru Lei

    2016-01-01

    Objective:To explore the effect of hs-CRP level and nutritional status on the pulmonary function in patients with maintenance hemodialysis (MHD). Methods: A total of 30 patients with chronic renal failure (CRF) who were admitted in our hospital from August, 2014 to August, 2015 for hemodialysis were included in the study. A volume of 4mL morning fasting elbow venous blood before and after hemodialysis was extracted, and was then centrifuged for serum. The levels of Hb, Alb, and PA were detected. VC, FVC, FEV1, FEV1/FVC, PEF, and MMEF were determined. Results: The levels of Hb, Alb, and PA after hemodialysis were significantly higher than those before hemodialysis (P<0.05). VC, FVC, FEV1, FEV1/FVC, PEF, and MMEF after hemodialysis were significantly improved when compared with before treatment (P<0.05). The comparison of VC, FVC, FEV1, FEV1/FVC, PEF, and MMEF among patients with different levels of hs-CRP was statistically significant (P<0.05). Conclusions:The reduction of pulmonary function in different degrees exists in MHD patients. MHD is kind of effective method to improve the pulmonary function in patients with CRF. The effective improvement of nutritional status and the reduction of in vivo inflammatory reaction in patients with CRF in the clinic can relieve the deterioration of pulmonary function to a certain degree so that to improve the ventilation function and enhance the living quality.

  3. HS-SPME-GC-MS ANALYSIS OF VOLATILE AND SEMI-VOLATILE COMPOUNDS FROM DRIED LEAVES OF Mikania glomerata Sprengel

    Directory of Open Access Journals (Sweden)

    Esmeraldo A. Cappelaro

    2015-03-01

    Full Text Available This paper reports on the identification of volatile and semi-volatile compounds and a comparison of the chromatographic profiles obtained by Headspace Solid-Phase Microextraction/Gas Chromatography with Mass Spectrometry detection (HS-SPME-GC-MS of dried leaves of Mikania glomerata Sprengel (Asteraceae, also known as 'guaco.' Three different types of commercial SPME fibers were tested: polydimethylsiloxane (PDMS, polydimethylsiloxane/divinylbenzene (PDMS/DVB and polyacrylate (PA. Fifty-nine compounds were fully identified by HS-SPME-HRGC-MS, including coumarin, a marker for the quality control of guaco-based phytomedicines; most of the other identified compounds were mono- and sesquiterpenes. PA fibers performed better in the analysis of coumarin, while PDMS-DVB proved to be the best choice for a general and non-selective analysis of volatile and semi-volatile guaco-based compounds. The SPME method is faster and requires a smaller sample than conventional hydrodistillation of essential oils, providing a general overview of the volatile and semi-volatile compounds of M. glomerata.

  4. Metafore spaziali della conoscenza di sé nei dialoghi di H.S. Skovoroda. Fonti patristiche

    Directory of Open Access Journals (Sweden)

    Maria Grazia Bartolini

    2009-01-01

    Full Text Available Spatial Metaphors for Self-knowledge in the dialogues of H.S Skovoroda. Patristic Sources In this paper the Author analyzes some spatial metaphors informing H.S. Skovoroda’s representation of self-knowledge as a dynamic process. Knowledge of the true self – which is one of the recurring themes in the Ukrainian philosopher’s oeuvre – is often portrayed as tension between open (e.g. streets, markets, the sky, the planets… and closed spaces (e.g. the house, the room, with the ‘home’ being a symbol for the soul. As man seeking communion with God has to abandon what lies outside his inner self, the authentic gnoseological process is represented as an introverted movement through symbolic space. Broadly speaking, this very opposition harks back to Philo of Alexandria and Patristic thought, whose anti-physicist stance shaped their rejection of the phenomenological world as an ‘interior vs. exterior’ contrast. Furthermore, the broader biblical context in which those spatial terms appear is also taken into account, while demonstrating Skovoroda’s partial dependence on Patristic models. The fi nal part of the paper argues that the scheme underlying Neo-platonic emanation – which is itself to be considered as an oscillation between unity and dispersion – appears to be a symbolic model for Skovoroda’s spatial representation of self-knowledge.

  5. hs-CRP is strongly associated with coronary heart disease (CHD): A data mining approach using decision tree algorithm.

    Science.gov (United States)

    Tayefi, Maryam; Tajfard, Mohammad; Saffar, Sara; Hanachi, Parichehr; Amirabadizadeh, Ali Reza; Esmaeily, Habibollah; Taghipour, Ali; Ferns, Gordon A; Moohebati, Mohsen; Ghayour-Mobarhan, Majid

    2017-04-01

    Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm. Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP). Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age. Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Determination of 2-Methylisoborneol and Geosmin in Water by HS-SPME-GC-MS%HS-SPME-GC-MS法测定水中2-甲基异冰片及土臭素

    Institute of Scientific and Technical Information of China (English)

    黎莉; 曹芹; 曹旭静; 余俭

    2014-01-01

    Headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) was used to detect the trace 2-MIB, GSM in surface water. The optimal operation conditions of SPME were obtained as follows:extraction time 30 min, extraction temperature 70℃, NaCl 30%(mass fraction),desorption temperature 250℃in GC. Internal standard method was used to quantify, concentration of 2-MIB, GSM was linear with peak area in the range of 5-100 ng/L with the correlation coefficient (r2) of 0.999 5, 0.999 6, respectively. The detection limits of 2-MIB, GSM were 0.8, 1.7 ng/L, respectively. The method was used to detect water samples, the relative standard deviations of 2-MIB, GSM were 2.6%-6.3%(n=6), and the recoveries were 92%-112%. The method is simple and fast for the determination of trace odor compounds in water.%采用顶空固相微萃取-气质联用(HS-SPME-GC-MS)的方法对地表水中2-甲基异冰片(2-MIB)和土臭素(GSM)进行分析测定。通过试验确定了HS-SPME的最佳萃取条件:萃取头为DVB/CAR/PDMS,萃取时间为30 min,萃取温度为70℃,NaCl的加入量为30%(质量分数),萃取纤维在GC上的解吸温度为250℃。用内标法进行定量,2-MIB,GSM的质量浓度在5~100 ng/L范围内与色谱峰面积呈良好的线性关系,线性相关系数(r2)分别为0.9997,0.9970,检出限分别为0.8,1.7 ng/L。采用该法对水样进行测定,2-MIB,GSM测定结果的相对标准偏差为2.6%~6.3%(n=6),加标回收率为92%~112%。该方法能简单、快速地测定水中痕量嗅味物质。

  7. HS-streamCube: Real-time multi-dimensional analysis system on network security event stream%HS-StreamCube:网络安全事件流实时多维分析系统

    Institute of Scientific and Technical Information of China (English)

    甘亮; 李润恒; 贾焰; 刘健

    2013-01-01

    大规模网络安全监控应用中,决策者应用数据流联机在线分析(Stream OLAP)技术对网络安全事件流建立流数据方(Stream Cube)进行实时分析,以了解当前网络安全状况并动态评估当前网络安全态势.由于内存容量有限,Stream Cube只关注当前时间窗口内的数据,而对于时间窗口外的过期数据则采用近似存储或简单地丢弃,所以不支持超出时间窗口范围的大时间窗口查询.针对以上缺陷,提出一种多维多层安全事件流实时分析框架HS-StreamCube,采用内存和外存两层混合存储模式实现任意时间窗口的精确查询;然后根据数据流特点重点研究两层混合存储模式下HS-StreamCube的模型、构建、存储管理和查询等;最后通过实验验证该系统的可用性和高效性.%In the applications of large-scale network security monitoring, data stream of security e-vents is analysised real-timely to acquire the characteristic of current security in the network and to assess dynamically the current security situation with Stream OLAP by building Stream Cube. Because of the limited memory capacity, Stream Cube only concerned about the current data within the time window, but expired data is stored approximately or simply discarded, so it do not support the query with time beyond the scope of current time window. We propose a real-time StreamCube-based multi-dimensional and multi-level analysis framework on security event stream, Hybrid StorageStreamCube, which is implemented by a two-tier (memory and disk) storage model. On the basis of characteristics of data stream,we focus on the modeling,building,storing and querying of HS-StreamCube within the two-tier storage model. Efficient experiments verify the availability and efficiency of the system.

  8. Effect of ultrasound combined with determination of CA19-9 and hs-CRP on the accuracy of early diagnosis of gallbladder cancer

    Directory of Open Access Journals (Sweden)

    Hang-yu ZHANG

    2014-03-01

    Full Text Available Objective  To investigate the value of ultrasound combined with tumor marker CA19-9 and high sensitivity C reactive protein (hs-CRP on the accuracy of early diagnosis of gallbladder cancer. Methods  Ninety-five patients with pathologically confirmed primary gallbladder cancer who received cholecystectomy from Jan. 2008 to Jan. 2013 in our hospital were included in the study. The study also included 51 patients with benign cystic lesions and 51 healthy adults. In all patients, results of pathological examination, B-ultrasound, serum CA19-9 and hs-CRP detection were obtained. In all the healthy adults gallbladder diseases were ruled out, but all of them received serum CA19-9 and hs-CRP determination. Results  Of 95 patients with primary gallbladder cancer, B-ultrasound showed nodules in the gallbladder lumen in 31, tumor mass in 40, and thickened wall in 24. Histological examination showed adenocarcinoma in 87 cases, adenosquamous carcinoma in 6, and squamous carcinoma in 2. There was a statistical difference in hs-CRP and CA19-9 levels between the groups (P<0.05, and the highest level appeared in gallbladder cancer group. There was a high sensitivity but low specificity of CA19-9 or hs-CRP in the diagnosis of primary gallbladder cancer. The sensitivity and specificity were 74.7% and 75.0% when primary gallbladder cancer was diagnosed with B-ultrasound. The positive values of CA19-9 and hs-CRP were ≥100U/ml and ≥6mg/L respectively, when they were combined with B-ultrasound as a single serology factor. When both B-ultrasound and serum levels of CA19-9 and hs-CRP were positive, the diagnostic sensitivity and specificity were 71.6% and 84.4% respectively. When B-ultrasound or serum CA19-9 and hs-CRP were positive, the diagnostic sensitivity and specificity were 98.9% and 66.7% respectively. Conclusions  Combination of B-ultrasound and determination of serum of CA19-9 and hs-CRP can improve the accuracy of the diagnosis of gallbladder

  9. Optimizaion of component HS-SPMEz extraction from Zhenjiang fragrance vinegar by response surface methodology%利用响应面法优化HS-SPME镇江香醋香气成分的条件

    Institute of Scientific and Technical Information of China (English)

    李国栋; 孙宗保

    2009-01-01

    为了优化镇江香醋香气成分的提取,在单因素实验的基础上,根据Box-Benhnken的中心组合实验设计原理,采用3因素3水平的响应面分析法,以提取物质的质(色)谱图总峰面积为响应值做响应面和等高线图.结果表明,HS-SPME萃取镇江香醋香气成分的最佳条件是氯化钠添加量2.5 g,萃取温度50.16℃,萃取时间39.76 min.

  10. Long-term Temozolomide Treatment Induces Marked Amino Metabolism Modifications and an Increase in TMZ Sensitivity in Hs683 Oligodendroglioma Cells

    Directory of Open Access Journals (Sweden)

    Delphine Lamoral-Theys

    2010-01-01

    Full Text Available Gliomas account for more than 50% of all primary brain tumors. The worst prognosis is associated with gliomas of astrocytic origin, whereas gliomas with an oligodendroglial origin offer higher sensitivity to chemotherapy, especially when oligodendroglioma cells display 1p19q deletions. Temozolomide (TMZ provides therapeutic benefits and is commonly used with radiotherapy in highly malignant astrocytic tumors, including glioblastomas. The actual benefits of TMZ during long-term treatment in oligodendroglioma patients have not yet been clearly defined. In this study, we have investigated the effects of such a long-term TMZ treatment in the unique Hs683 oligodendroglioma model. We have observed increased TMZ sensitivity of Hs683 orthotopic tumors that were previously treated in vitro with months of progressive exposure to increasing TMZ concentrations before being xenografted into the brains of immunocompromised mice. Whole-genome and proteomic analyses have revealed that this increased TMZ sensitivity of Hs683 oligodendroglioma cells previously treated for long periods with TMZ can be explained, at least partly, by a TMZ-induced p38-dependant dormancy state, which in turn resulted in changes in amino acid metabolism balance, in growth delay, and in a decrease in Hs683 oligodendroglioma cell-invasive properties. Thus, long-term TMZ treatment seems beneficial in this Hs683 oligodendroglioma model, which revealed itself unable to develop resistance against TMZ.

  11. 冠心病患者血清IL-17、IL-35及hs-CRP水平的变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    李大军; 车航; 付勇

    2016-01-01

    目的:探讨IL-17、IL-35和hs-CRP在冠心病发病过程中的作用及临床意义。方法采用ELISA方法对152例冠心病患者(AMI组52例,UA组64例,SA组36例)和40例正常人(对照组)血清中IL-17、IL-35水平进行检测;免疫比浊法检测hs-CRP。结果血清中IL-17和IL-35水平呈明显负相关,IL-17与hs-CRP的水平呈正相关,IL-35与hs-CRP的水平呈负相关。结论 IL-17、IL-35和hs-CRP的水平与冠心病的发生发展密切相关,有重要临床意义。

  12. Restriction of the use of hazardous substances (RoHS in the personal computer segment: analysis of the strategic adoption by the manufacturers settled in Brazil

    Directory of Open Access Journals (Sweden)

    Ademir Brescansin

    2015-09-01

    Full Text Available The enactment of the RoHS Directive (Restriction of Hazardous Substances in 2003, limiting the use of certain hazardous substances in electronic equipment has forced companies to adjust their products to comply with this legislation. Even in the absence of similar legislation in Brazil, manufacturers of personal computers which are located in this country have been seen to adopt RoHS for products sold in the domestic market and abroad. The purpose of this study is to analyze whether these manufacturers have really adopted RoHS, focusing on their motivations, concerns, and benefits. This is an exploratory study based on literature review and interviews with HP, Dell, Sony, Lenovo, Samsung, LG, Itautec, and Positivo, using summative content analysis. The results showed that initially, global companies adopted RoHS to market products in Europe, and later expanded this practice to all products. Brazilian companies, however, adopted RoHS to participate in the government’s sustainable procurement bidding processes. It is expected that this study can assist manufacturers in developing strategies for reducing or eliminating hazardous substances in their products and processes, as well as help the government to formulate public policies on reducing risks of environmental contamination.

  13. The association of hs-CRP with fasting and postprandial plasma lipids in patients with type 2 diabetes is disrupted by dietary monounsaturated fatty acids.

    Science.gov (United States)

    Bozzetto, L; De Natale, C; Di Capua, L; Della Corte, G; Patti, L; Maione, S; Riccardi, G; Rivellese, A A; Annuzzi, G

    2013-04-01

    The aim of the study was to evaluate whether two dietary approaches recommended for diabetes mellitus and cardiovascular prevention-high-MUFA or complex carbohydrates/fiber-differently influence inflammation. A 4-week crossover study in 12 individuals with type 2 diabetes was performed. Fasting and postprandial hs-CRP plasma levels were not significantly different after a high-carbohydrate/high-fiber/low-glycemic index (CHO/fiber) and a high-MUFA diet. Compared with fasting, hs-CRP levels decreased significantly after the MUFA but not after the CHO/fiber meal. Triglyceride-rich lipoproteins were significantly lower after the CHO/fiber than the MUFA diet. At fasting and postprandially, hs-CRP correlated with triglyceride in whole plasma, chylomicrons, small and large VLDL after the CHO/fiber but not after the MUFA diet. In conclusion, a MUFA-rich diet and a carbohydrate/fiber-rich diet induced similar effects on plasma hs-CRP concentrations. However, these dietary approaches seem to influence hs-CRP levels through different mechanisms. i.e., direct acute postprandial effects by MUFA and triglyceride-rich lipoproteins mediated effects by CHO/fiber.

  14. The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment

    Directory of Open Access Journals (Sweden)

    Yilmaz Ozbay

    2007-01-01

    Materials and method. We measured serum hs-CRP level in 40 CAE (26 males, mean age: 56.32±9 years and 41 O-CAD (34 males, mean age: 57.19±10 years patients referred for elective coronary angiography at baseline and after 3-month statin and ACE inhibitor treatment. Results. Plasma hs-CRP levels were significantly higher in CAE group than O-CAD group at baseline (2.68±66 mg/L versus 1,64±64, resp., P<.0001. Plasma hs-CRP levels significantly decreased from baseline 3 months later in the CE (from 2.68±0.66 mg/L to 1.2±0.53 mg/L, P<.0001 as well as in the O-CAD group (from 1.64±0.64 mg/L to 1.01±0.56 mg/L, P<.001. Conclusion. We think that hs-CRP measurement may be a good prognostic value in CAE patients as in stenotic ones. Further placebo-controlled studies are needed to evaluate the clinical significance of this decrease in hs-CRP.

  15. Impaired facial emotion recognition in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS): Side and age at onset matters.

    Science.gov (United States)

    Hlobil, Ulf; Rathore, Chaturbhuj; Alexander, Aley; Sarma, Sankara; Radhakrishnan, Kurupath

    2008-08-01

    To define the determinants of impaired facial emotion recognition (FER) in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS), we examined 76 patients with unilateral MTLE-HS, 36 prior to antero-mesial temporal lobectomy (AMTL) and 40 after AMTL, and 28 healthy control subjects with a FER test consisting of 60 items (20 each for anger, fear, and happiness). Mean percentages of the accurate responses were calculated for different subgroups: right vs. left MTLE-HS, early (age at onset Happiness recognition was significantly better in post-AMTL MTLE-HS patients compared to pre-AMTL patients while anger and fear recognition did not differ. We conclude that patients with right MTLE-HS with age at seizure onset <6 years are maximally predisposed to impaired fear recognition. In them, right AMTL does not further worsen FER abilities. Longitudinal studies comparing FER in the same patients before and after AMTL will be required to refine and confirm our cross-sectional observations.

  16. Analysis of IGF-1, Lp-PLA2, hs-CRP, Hcy levels in type 2 diabetes patients complicated with carotid atherosclerosis

    Institute of Scientific and Technical Information of China (English)

    Guan-Lun Ye; Zhuo-Zhang Luo; Wei-Ming Zheng

    2015-01-01

    Objective: To study the levels of IGF-1, Lp-PLA2, hs-CRP, Hcy in type 2 diabetes patients complicated with carotid atherosclerosis. Methods: 90 cases of type 2 diabetes patients complicated with carotid atherosclerosis in our hospital from May 2013 to August 2014 were enrolled in observation group and further divided into mild stenosis group, moderate stenosis group, severe stenosis group according to the judgment of color ultrasonography on carotid artery carotid artery stenosis, divided into mild sclerosis group, moderate sclerosis group, severe sclerosis group according to carotid artery plaque score. At the same time type 2 diabetic patients without complications in our hospital were enrolled in the control group. Then serums IGF-1, Lp-PLA2, hs-CRP, Hcy levels were assayed. Results: serum IGF-1, Lp-PLA2, hs-CRP, Hcy levels of observation group were higher than those of control group; as carotid artery stenosis and sclerosis degree got greater, serum IGF-1, Lp-PLA2, hs-CRP, Hcy levels were higher. Conclusion:serum IGF-1, Lp-PLA2, hs-CRP, Hcy levels in type 2 diabetes patients complicated with carotid atherosclerosis abnormally increased and it can reflect the degree of carotid stenosis and sclerosis.

  17. Study on the changes of blood lipids,platelet parameters and hs-CRP in different types of coronary heart disease%不同临床类型冠心病患者血脂、血小板参数及 hs-CRP 水平比较研究

    Institute of Scientific and Technical Information of China (English)

    王一平

    2016-01-01

    Objective To investigate the changes of blood lipids,platelet parameters and hs-CRP in different types of coronary heart disease (CHD).Methods A total of 271 hospitalized patients with CHD between January 2012 and Au-gust 2014 were enrolled.Patients were divided into stable angina group (SAP),unstable angina group (UAP),and a-cute myocardial infarction group (AMI).The levels of blood lipids,platelet parameters and hs-CRP in different types of CHD were examined and recorded.Results Statistically significant differences were found in TC,TG,LDL-C,hs-CRP, PLT,MPV,and PDW among three groups (P <0.05 or P <0.01).There were no differences in HDL-C and PCT a-mong them.The levels of TC,TG,LDL-C,hs-CRP,PLT,MPV,and PDW in the UAP and AMI group were significant-ly higher than that in the SAP group (P <0.05 or P <0.01).Compared with the UAP group,the levels of TC,TG, LDL-C,hs-CRP,PLT,MPV,and PDW in the AMI group were showed statistically significant differences (P <0.01). The number of cases of high hs-CRP group,intermediate hs-CRP group,and low hs-CRP group were 40.59%, 45.02%,and 14.39%,respectively.The highest group of SAP,UAP,and AMI were intermediate hs-CRP group (61.96%),high hs-CRP group (55.36%),and high hs-CRP group (88.46%),respectively.Conclusion There were different levels of blood lipids,platelet parameters and hs-CRP in different types of CHD.Testing of the blood lipids, platelet parameters and hs-CRP in patients with CHD has important value in the diagnosis and prognosis of the disease.%目的:了解不同临床类型冠心病(coronary heart disease,CHD)患者血脂、血小板参数及 hs-CRP 水平变化情况。方法选择2012年1月至2014年8月我院收治的271例,将患者分为三组:稳定型心绞痛(SAP)组163例,不稳定型心绞痛(UAP)组56例,急性心肌梗死(AMI)组52例,对不同组进行血脂、血小板参数及 hs-CRP 水平检测。结果三组患者 TC、TG、LDL-C、hs-CRP、PLT、MPV 和 PDW

  18. 76 FR 4939 - John M. Chois; Decision and Order

    Science.gov (United States)

    2011-01-27

    ... suspension of Registrant's license to practice medicine. Id. The Order thus alleged that Registrant is... address of Advanced Aesthetics, 7425 Conroy Road, Orlando, Florida 32835. His registration does not expire.... Registrant's license to practice medicine remains suspended as of the date of this Order. Thus, Registrant...

  19. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Lindsay, K.L

    2014-07-01

    The aim of the study is to explore the dietary intakes of a prominent ethnic minority group of women from Sub-Saharan Africa during pregnancy, in order to identify nutritional issues of concern which may impact on pregnancy outcomes and whether different food based dietary guidelines may be required to meet their needs.

  20. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Lindsay, K.L

    2014-07-01

    The aim of the study is to explore the dietary intakes of a prominent ethnic minority group of women from Sub-Saharan Africa during pregnancy, in order to identify nutritional issues of concern which may impact on pregnancy outcomes and whether different food based dietary guidelines may be required to meet their needs.

  1. Antiproliferation effects of selected Tanzania plants | Choi | African ...

    African Journals Online (AJOL)

    Our screening of indigenous medicinal plants from Tanzania has led to the ... Material and methods: The current study investigates the cytotoxic activity of methanol ... Result 16% of the tested plant extracts showed moderate to strong inhibitory ...

  2. The Inlfuence of CE RoHS 2.0 on Medical Device and Solutions%CE RoHS 2.0对医疗器械企业的影响及企业应对措施

    Institute of Scientific and Technical Information of China (English)

    黄燕彬

    2014-01-01

    随着RoHS指令修订,RoHS 2.0被纳入为有源医疗器械产品CE认证必须符合的指令之一。2014年7月22日,M D D指令(93/42/E E C)中的有源医疗器械产品投放欧盟市场必须符合RoHS 2.0要求。2016年7月22日,IVD指令(98/79/EC)的有源医疗器械产品投放欧盟市场必须符合RoHS 2.0要求。一旦违规,企业将可能受到欧盟的处罚及造成重大损失,甚至禁止企业产品的出口,这在电子产品业界已早有先例。RoHS 2.0指令要求医疗器械企业必须建立内部过程管理控制,供应链及物料符合性评价,产品符合性验证及制作技术文档等工作,来确保医疗器械产品持续符合RoHS 的要求。SGS凭借多年专业技术及服务经验,能为医疗器械企业满足RoHS 2.0提供系统和有效措施以确保产品的合规性,帮助医疗器械企业更快进入目标市场创造更大的价值。%With the RoHS directive recast, RoHS 2.0 become one of directives that active medical device should compliance with when apply for CE certiifcation. Active medical device in the scope of Medical device directive (93/42/EEC) placing on the market must compliance with RoHS 2.0 directive requirement after July 22, 2014. And Active medical device in the scope of in vitro diagnostic medical devices (98/79/EC) placing on the market should meet the requirements of RoHS 2.0 after July 22, 2016. Manufacturer wil be disciplined by the European Union and caused signiifcant losses if not conform to RoHS, even more serious, products would prohibit of export. Event like that have been happen in electrical and electronic industry. Establish internal control process, assess compliance of materials in supplier chain, verify RoHS product conformity for RoHS and prepare technical documentation are the base requirements of RoHS. Active medical device manufacturer should meet those requirements to assure their products continue compliance with RoHS. With professional

  3. Changes in the structure of the accretion disc of HS1804+67 through the outburst cycle

    CERN Document Server

    Baptista, R; Baptista, Raymundo

    1999-01-01

    We report on the analysis of high-speed photometry of the dwarf-nova HS1804+67 through its outburst cycle with eclipse mapping techniques. Eclipse maps show evidences of the formation of a spiral structure in the disc at the early stages of the outburst and reveal how the disc expands during the rise until its fills most of the primary Roche lobe at maximum light. During the decline phase, the disc becomes progressively fainter as the cooling front moves inwards from the outer regions, until only a small bright region around the white dwarf is left at minimum light. The variable part of the uneclipsed light is possibly due to emission in a wind emanating from the inner parts of the disc. The emission from this region is sensitive to the mass accretion rate.

  4. Measurement of the isotope ratio of acetic acid in vinegar by HS-SPME-GC-TC/C-IRMS.

    Science.gov (United States)

    Hattori, Ryota; Yamada, Keita; Shibata, Hiroki; Hirano, Satoshi; Tajima, Osamu; Yoshida, Naohiro

    2010-06-23

    Acetic acid is the main ingredient of vinegar, and the worth of vinegar often depends on the fermentation of raw materials. In this study, we have developed a simple and rapid method for discriminating the fermentation of the raw materials of vinegar by measuring the hydrogen and carbon isotope ratio of acetic acid using head space solid-phase microextraction (HS-SPME) combined with gas chromatography-high temperature conversion or combustion-isotope ratio mass spectrometry (GC-TC/C-IRMS). The measurement of acetic acid in vinegar by this method was possible with repeatabilities (1sigma) of +/-5.0 per thousand for hydrogen and +/-0.4 per thousand for carbon, which are sufficient to discriminate the origin of acetic acid. The fermentation of raw materials of several vinegars was evaluated by this method.

  5. Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB.

    Science.gov (United States)

    Chen, Xi; Liu, Xi-shuang

    2016-03-01

    This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 μmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.

  6. Assessment of elder mistreatment in two American Indian samples: psychometric characteristics of the HS-EAST and the Native Elder Life-Financial Exploitation and -Neglect measures.

    Science.gov (United States)

    Jervis, Lori L; Fickenscher, Alexandra; Beals, Janette

    2014-04-01

    Although elder mistreatment among ethnic minorities is increasingly gaining attention, our empirical knowledge of this phenomenon among American Indians remains quite limited, especially with respect to measurement. The Shielding American Indian Elders (SAIE) Project used a collaborative approach to explore culturally informed measurement of elder mistreatment in two American Indian elder samples (a Northern Plains reservation and a South Central metropolitan area). The project sought to investigate the performance characteristics of the commonly used Hwalek-Sengstock Elder Abuse Screening Test (HS-EAST), as well as to examine the psychometric properties of a new measure developed to capture culturally salient aspects of mistreatment in American Indian contexts--the Native Elder Life Scale (NELS). Using methods and samples comparable to those in the literature, the HS-EAST performed adequately in these Native samples. The NELS also shows promise for use with this population and assesses different aspects of elder mistreatment than does the HS-EAST.

  7. IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T.

    Science.gov (United States)

    Frommer, Klaus W; Reichenmiller, Katharina; Schutt, Burkhardt S; Hoeflich, Andreas; Ranke, Michael B; Dodt, Gabriele; Elmlinger, Martin W

    2006-08-01

    There is evidence that insulin-like growth factor-binding protein (IGFBP-2), a modulator of the actions of IGFs, also has IGF-independent effects in human tumor cell lines. These involve specific binding of IGFBP-2 to alpha5beta1-integrin, followed by alterations in the phosphorylation status of downstream signaling molecules. Previously, IGFBP-2 has also been shown to be associated with cell proliferation, adhesion and migration. Here, we investigated direct effects of IGFBP-2 on apoptosis and alterations in the expression of related proteins. The breast cancer cell line Hs578T, which shows no IGFBP-2 production of its own and is independent of the IGF-I receptor, was treated with human recombinant IGFBP-2 in order to study the changes in gene expression induced by IGFBP-2. The methods employed for this purpose were oligonucleotide microarrays, real-time RT-PCR, western blotting, and immunoassays. Out of the 440 genes covered by the Oligo GEArray Human Cancer Microarray OHS-802, the expression of 77 genes was directly influenced by IGFBP-2. By the use of real-time quantitative RT-PCR, the gene expression of Nuclear Factor (NF)kappaB, p53, transforming growth factor beta (TGF beta-1), LAMB1 (Laminin, Beta 1), Bcl-2, and IIp45 was found to be significantly upregulated (by 1.2- to 3.05-fold; all P 1.5-fold. By using an ELISA-based and a flow cytometry-based apoptosis assay, IGFBP-2 was found to have a pro-apoptotic effect on Hs578T cells. Our results suggest that IGFBP-2-induced gene expressions are of functional significance for proliferation, cell adhesion, cell migration and apoptosis, and showed that IGFBP-2 can promote apoptosis in tumor cells independent of IGF.

  8. D-Alanine-Controlled Transient Intestinal Mono-Colonization with Non-Laboratory-Adapted Commensal E. coli Strain HS.

    Science.gov (United States)

    Cuenca, Miguelangel; Pfister, Simona P; Buschor, Stefanie; Bayramova, Firuza; Hernandez, Sara B; Cava, Felipe; Kuru, Erkin; Van Nieuwenhze, Michael S; Brun, Yves V; Coelho, Fernanda M; Hapfelmeier, Siegfried

    2016-01-01

    Soon after birth the mammalian gut microbiota forms a permanent and collectively highly resilient consortium. There is currently no robust method for re-deriving an already microbially colonized individual again-germ-free. We previously developed the in vivo growth-incompetent E. coli K-12 strain HA107 that is auxotrophic for the peptidoglycan components D-alanine (D-Ala) and meso-diaminopimelic acid (Dap) and can be used to transiently associate germ-free animals with live bacteria, without permanent loss of germ-free status. Here we describe the translation of this experimental model from the laboratory-adapted E. coli K-12 prototype to the better gut-adapted commensal strain E. coli HS. In this genetic background it was necessary to complete the D-Ala auxotrophy phenotype by additional knockout of the hypothetical third alanine racemase metC. Cells of the resulting fully auxotrophic strain assembled a peptidoglycan cell wall of normal composition, as long as provided with D-Ala and Dap in the medium, but could not proliferate a single time after D-Ala/Dap removal. Yet, unsupplemented bacteria remained active and were able to complete their cell cycle with fully sustained motility until immediately before autolytic death. Also in vivo, the transiently colonizing bacteria retained their ability to stimulate a live-bacteria-specific intestinal Immunoglobulin (Ig)A response. Full D-Ala auxotrophy enabled rapid recovery to again-germ-free status. E. coli HS has emerged from human studies and genomic analyses as a paradigm of benign intestinal commensal E. coli strains. Its reversibly colonizing derivative may provide a versatile research tool for mucosal bacterial conditioning or compound delivery without permanent colonization.

  9. Suppressive effect of CORM-2 on LPS-induced platelet activation by glycoprotein mediated HS1 phosphorylation interference.

    Directory of Open Access Journals (Sweden)

    Dadong Liu

    Full Text Available In recent years, it has been discovered that septic patients display coagulation abnormalities. Platelets play a major role in the coagulation system. Studies have confirmed that carbon monoxide (CO has important cytoprotective and anti-inflammatory function. However, whether CO could alter abnormal activation of platelets and coagulation and thereby reduce the incidence of mortality during sepsis has not been defined. In this report, we have used CO-releasing molecules (CORM-2 to determine whether CO inhibits LPS-induced abnormal activation of platelets and have explored the potential mechanisms. LPS was used to induce activation of platelets in vitro, which were purified from the peripheral venous blood of healthy adult donors. CORM-2 was applied as a potential therapeutic agent. CORM-2 preconditioning and delayed treatment were also studied. We found that in the LPS groups, the function of platelets such as spreading, aggregation, and release were enhanced abnormally. By contrast, the platelets in the CORM-2 group were gently activated. Further studies showed that the expression of platelet membrane glycoproteins increased in the LPS group. Coincidently, both hematopoietic lineage cell-specific protein 1 and its phosphorylated form also increased dramatically. These phenomena were less dramatically seen in the CORM-2 groups. Taken together, we conclude that during LPS stimulation, platelets were abnormally activated, and this functional state may be associated with the signal that is transmitted between membrane glycoproteins and HS1. CORM-released CO suppresses the abnormal activation of platelets by interfering with glycoprotein-mediated HS1 phosphorylation.

  10. Pathomechanism of Insulin Resistance in Men with Central Obesity: Correlation of GGT, GPx, hs-CRP and Plasma Total Cysteine

    Directory of Open Access Journals (Sweden)

    Ritawaty Ritawaty

    2013-08-01

    Full Text Available BACKGROUND: Gamma glutamyltransferase (GGT was reported recently to be associated with inflammation, oxidative stress and increased amino acid. However, role of GGT in insulin resistance pathomechanism is not exactly known. Therefore correlation of GGT with inflammation, oxidative stress and elevated amino acid, in men with central obesity need to be confirmed. METHODS: A cross-sectional study was designed. Men with central obesity were recruited and selected. Anthropometric parameters, creatinine, hs-CRP, fasting glucose, fasting insulin, glutathione peroxidase (GPx activity, GGT, plasma total cysteine (tCys and fatty liver were measured. Subjects were then divided in 4 groups based on waist circumference (WC and fatty liver: Group I: WC ≤100 cm, without fatty liver; Group II: WC ≤100 cm, with fatty liver; Group III: WC >100 cm, without fatty liver; Group IV: WC >100 cm, with fatty liver. All biochemical characteristics in each group were then statistically analyzed. RESULTS: Seventy-two men with central obesity were selected. Numbers of subjects in each group were: Group I: n=33; Group II: n=5; Group III: n=17; Group IV: n=17. We found significant difference of HOMA-IR between Group I and IV, significant correlation between GGT and HOMAIR, and significant negative correlation between tCys with HOMA-IR in Group IV. CONCLUSIONS: GGT was significantly correlated with HOMA-IR in men with WC >100 cm and fatty liver. Further investigation with more subjects is necessary to determine clear GGT cut-off to distinguish subjects with fatty liver and insulin resistance. KEYWORDS: GGT, hs-CRP, GPx, tCys, HOMA-IR, insulin resistance.

  11. Analysis of cardiovascular responses to the H2S donors Na2S and NaHS in the rat.

    Science.gov (United States)

    Yoo, Daniel; Jupiter, Ryan C; Pankey, Edward A; Reddy, Vishwaradh G; Edward, Justin A; Swan, Kevin W; Peak, Taylor C; Mostany, Ricardo; Kadowitz, Philip J

    2015-08-15

    Hydrogen sulfide (H2S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to the H2S donors Na2S and NaHS were investigated in the anesthetized rat. The intravenous injections of Na2S and NaHS 0.03-0.5 mg/kg produced dose-related decreases in systemic arterial pressure and heart rate, and at higher doses decreases in cardiac output, pulmonary arterial pressure, and systemic vascular resistance. H2S infusion studies show that decreases in systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance are well-maintained, and responses to Na2S are reversible. Decreases in heart rate were not blocked by atropine, suggesting that the bradycardia was independent of parasympathetic activation and was mediated by an effect on the sinus node. The decreases in systemic arterial pressure were not attenuated by hexamethonium, glybenclamide, N(w)-nitro-L-arginine methyl ester hydrochloride, sodium meclofenamate, ODQ, miconazole, 5-hydroxydecanoate, or tetraethylammonium, suggesting that ATP-sensitive potassium channels, nitric oxide, arachidonic acid metabolites, cyclic GMP, p450 epoxygenase metabolites, or large conductance calcium-activated potassium channels are not involved in mediating hypotensive responses to the H2S donors in the rat and that responses are not centrally mediated. The present data indicate that decreases in systemic arterial pressure in response to the H2S donors can be mediated by decreases in vascular resistance and cardiac output and that the donors have an effect on the sinus node independent of the parasympathetic system. The present data indicate that the mechanism of the peripherally mediated hypotensive response to the H2S donors is uncertain in the intact rat. Copyright © 2015 the American Physiological Society.

  12. Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule.

    Directory of Open Access Journals (Sweden)

    Kazuyuki Sugahara

    Full Text Available The angiogenic process is controlled by variety of factors of which the vascular endothelial growth factor (VEGF pathway plays a major role. A series of heparan sulfate mimetic small molecules targeting VEGF/VEGFR pathway has been synthesized. Among them, compound 8 (2-butyl-5-chloro-3-(4-nitro-benzyl-3H-imidazole-4-carbaldehyde was identified as a significant binding molecule for the heparin-binding domain of VEGF, determined by high-throughput-surface plasmon resonance assay. The data predicted strong binding of compound 8 with VEGF which may prevent the binding of VEGF to its receptor. We compared the structure of compound 8 with heparan sulfate (HS, which have in common the functional ionic groups such as sulfate, nitro and carbaldehyde that can be located in similar positions of the disaccharide structure of HS. Molecular docking studies predicted that compound 8 binds at the heparin binding domain of VEGF through strong hydrogen bonding with Lys-30 and Gln-20 amino acid residues, and consistent with the prediction, compound 8 inhibited binding of VEGF to immobilized heparin. In vitro studies showed that compound 8 inhibits the VEGF-induced proliferation migration and tube formation of mouse vascular endothelial cells, and finally the invasion of a murine osteosarcoma cell line (LM8G7 which secrets high levels of VEGF. In vivo, these effects produce significant decrease of tumor burden in an experimental model of liver metastasis. Collectively, these data indicate that compound 8 may prevent tumor growth through a direct effect on tumor cell proliferation and by inhibition of endothelial cell migration and angiogenesis mediated by VEGF. In conclusion, compound 8 may normalize the tumor vasculature and microenvironment in tumors probably by inhibiting the binding of VEGF to its receptor.

  13. D-Alanine-Controlled Transient Intestinal Mono-Colonization with Non-Laboratory-Adapted Commensal E. coli Strain HS.

    Directory of Open Access Journals (Sweden)

    Miguelangel Cuenca

    Full Text Available Soon after birth the mammalian gut microbiota forms a permanent and collectively highly resilient consortium. There is currently no robust method for re-deriving an already microbially colonized individual again-germ-free. We previously developed the in vivo growth-incompetent E. coli K-12 strain HA107 that is auxotrophic for the peptidoglycan components D-alanine (D-Ala and meso-diaminopimelic acid (Dap and can be used to transiently associate germ-free animals with live bacteria, without permanent loss of germ-free status. Here we describe the translation of this experimental model from the laboratory-adapted E. coli K-12 prototype to the better gut-adapted commensal strain E. coli HS. In this genetic background it was necessary to complete the D-Ala auxotrophy phenotype by additional knockout of the hypothetical third alanine racemase metC. Cells of the resulting fully auxotrophic strain assembled a peptidoglycan cell wall of normal composition, as long as provided with D-Ala and Dap in the medium, but could not proliferate a single time after D-Ala/Dap removal. Yet, unsupplemented bacteria remained active and were able to complete their cell cycle with fully sustained motility until immediately before autolytic death. Also in vivo, the transiently colonizing bacteria retained their ability to stimulate a live-bacteria-specific intestinal Immunoglobulin (IgA response. Full D-Ala auxotrophy enabled rapid recovery to again-germ-free status. E. coli HS has emerged from human studies and genomic analyses as a paradigm of benign intestinal commensal E. coli strains. Its reversibly colonizing derivative may provide a versatile research tool for mucosal bacterial conditioning or compound delivery without permanent colonization.

  14. The Value of HbA1c and hs-CRP Combined Detection in Diagnosis of Diabetic Retinopathy%HbA1c、hs-CRP 联合检测诊断糖尿病视网膜病变的价值

    Institute of Scientific and Technical Information of China (English)

    李孝才; 孙学芬; 吴建霞; 马雪燕

    2016-01-01

    目的:探讨糖化血红蛋白(HbA1c)和高敏 C 反应蛋白(hs-CRP)联合检测诊断糖尿病视网膜病变的价值。方法:选择正常体检者(A 组)、糖尿病无视网膜病变者(B 组)、糖尿病视网膜病变者(C 组)各72例,采用离子交换液相层析法和胶乳增强免疫比浊法测定 HbA1c 及 hs-CRP。结果:无视网膜病变组和视网膜病变组的 HbA1c 和 hs-CRP(mg/L)含量均比健康对照组高,具有统计学意义(P0.05);但是 HbA1c +Hs-CRP 诊断糖尿病视网膜病变的特异为90.3%,分别与 HbA1c 和 hs-CRP 存在明显差异(P 0.05); but specific to the HbA1c of hs CRP in the diagnosis of diabetic retinopathy was 90.3%, respectively and hs CRP and HbA1c exist significant difference (P< 0.05). Conclusion:The detection of HBA1c and Hs-CRPis helpful to early detection of diabetic retinopathy, which can be used asmonitoring indicators for progress and treatment effect in type 2 diabetes mellitus patients.

  15. Allan B. Chinen, ...e foram felizes para sempre: contos de fadas para adultos (in the ever after - fairy tales and the second half of life, 1989), interpretados segundo as teorias psicodinâmicas do desenvolvimento humano postuladas por Carl G. Jung e Erik Erikson, tradução de Cecília Casas, São Paulo, Cultrix, 1997, 183 pp.

    OpenAIRE

    1997-01-01

    Notas e recensões sobre Allan B. Chinen, ...e foram felizes para sempre: contos de fadas para adultos (in the ever after - fairy tales and the second half of life, 1989), interpretados segundo as teorias psicodinâmicas do desenvolvimento humano postuladas por Carl G. Jung e Erik Erikson, tradução de Cecília Casas, São Paulo, Cultrix, 1997, 183 pp.

  16. 急性颅脑损伤患者血清NSE、hs-CRP和S100B水平变化的临床意义

    Institute of Scientific and Technical Information of China (English)

    闫桂秀

    2016-01-01

    目的:探讨血清NSE、hs-CRP和S100B水平在急性颅脑损伤患者治疗前与治疗后的对比变化及其临床意义.方法:分别采用放射免疫分析法(RIA)、免疫比浊法(Immuno-turbidimetry)和酶联法(ELISA)检测血清NSE、hs-CRP和S100B,检测了急性颅脑损伤患者(32例)治疗前与治疗后血清NSE、hs-CRP和S100B的水平,和健康人组(35例)相关水平比较.结果:血清NSE、hs-CRP和S100B水平在急性颅脑损伤患者中,治疗前显著高于正常人组,两者有显著性的差异性(P<0.01),经二周治疗后恢复与正常人组相当,两者无显著性差异(P>0.05),血清NSE水平与hs-CRP、S100B呈显著正相关(r=0.5412 0.6018 P<0.01).结论:检测血清NSE、hs-CRP和S100B水平的变化有助于估计急性颅脑损伤患者的病情轻重和预后.

  17. Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects.

    Science.gov (United States)

    Cicero, Arrigo F G; Morbini, Martino; Parini, Angelo; Urso, Riccardo; Rosticci, Martina; Grandi, Elisa; Borghi, Claudio

    2016-01-01

    Our aim was to test, through a crossover, double-blind, placebo-controlled randomized clinical trial, if a short-term treatment with 10 mg monacolins combined with antioxidants could improve lipid pattern, high-sensitivity C-reactive protein (hs-CRP), and endothelial function in a small cohort of moderately hypercholesterolemic subjects. Thus, 25 healthy, moderately hypercholesterolemic subjects were consecutively enrolled and, after 4 weeks of stabilization diet, were randomized to the sequence placebo followed by a washout, monacolins or monacolins followed by a washout, placebo, with each period being 4 weeks long. At each study step, a complete lipid pattern, safety parameters, hs-CRP, and endothelial function have been measured. When compared to the placebo phase, during monacolin treatment, patients experienced a more favorable percentage change in total cholesterol (TC) (TC after monacolin treatment, -18.35%; TC after placebo treatment, -5.39%), low-density lipoprotein cholesterol (LDL-C) (LDL after monacolin treatment, -22.36%; LDL after placebo treatment, -1.38%), non-high-density lipoprotein cholesterol (HDL-C) (non-HDL after monacolin treatment, -22.83%; non-HDL after placebo treatment: -7.15%), hs-CRP (hs-CRP after monacolin treatment: -2.33%; hs-CRP after placebo treatment, 2.11%), and endothelial function (pulse volume displacement after monacolin treatment, 18.59%; pulse volume displacement after placebo treatment, -6.69%). No significant difference was observed with regard to triglycerides, HDL-cholesterol, and safety parameters. On the basis of our data, we could demonstrate that a 10 mg monacolin nutraceutical treatment appears to safely reduce cholesterolemia, hs-CRP, and markers of vascular remodeling in moderately hypercholesterolemic subjects. These results need to be confirmed in larger patient samples and in studies with longer duration.

  18. A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria.

    Science.gov (United States)

    Tutuncu, Yildiz; Satman, Ilhan; Celik, Selda; Dinccag, Nevin; Karsidag, Kubilay; Telci, Aysegul; Genc, Sema; Issever, Halim; Tuomilehto, Jaakko; Omer, Beyhan

    2016-01-01

    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60-65% and specificity 54-64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods.

  19. Clinical Significance of Determination of Serum Hypersensitive C-reactive Protein (hs-CRP) and E-Selectin Levels in Patients with Coronary Heart Diseases%冠心病患者血清hs-CRP和E-Selectin检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    杨春秀

    2007-01-01

    目的:探讨了冠心病患者血清超敏C反应蛋白(hs-CRP)和E-选择素(E-Selectin)水平的变化及意义.方法:应用免疫比浊法检测hs-CRP,ELISA法检测E-Selectin水平对58例冠心病患者进行了血清hs-CRP,E-Selectin水平检测.其中稳定型心绞痛25例,不稳定型心绞痛20例,急性心肌梗死13例,并以35名正常健康人作比较.结果:冠心病患者血清hs-CRP和E-Selectin水平明显高于正常人组(P<0.01),急性心肌梗死组和不稳定型心绞痛组有明显高于稳定型心绞痛组(P<0.01),冠心病组血清hs-CRP、E-Selectin水平与冠状动脉狭窄程度无明显相关性(P>0.05).结论:血清hs-CRP和E-Selectin水平的变化与冠心病的发生、发展有关,但与冠状动脉狭窄程度无关.

  20. JUPITER to Earth: A statin helps people with normal LDL-C and high hs-CRP, but what does it mean?

    OpenAIRE

    2009-01-01

    The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) (N Engl J Med 2008; 359:2195–2207) compared rosuvastatin (Crestor) 20 mg daily vs placebo in apparently healthy people who had levels of low-density lipoprotein cholesterol (LDL-C) lower than 130 mg/dL but elevated levels (≥ 2 mg/L) of high-sensitivity C-reactive protein (hs-CRP). Rosuvastatin treatment lowered LDL-C levels by 50% and hs-CRP levels by 37%, accompanied by a 44%...