WorldWideScience

Sample records for jump tales knock

  1. Chasing maximal performance: a cautionary tale from the celebrated jumping frogs of Calaveras County.

    Science.gov (United States)

    Astley, H C; Abbott, E M; Azizi, E; Marsh, R L; Roberts, T J

    2013-11-01

    Maximal performance is an essential metric for understanding many aspects of an organism's biology, but it can be difficult to determine because a measured maximum may reflect only a peak level of effort, not a physiological limit. We used a unique opportunity provided by a frog jumping contest to evaluate the validity of existing laboratory estimates of maximum jumping performance in bullfrogs (Rana catesbeiana). We recorded video of 3124 bullfrog jumps over the course of the 4-day contest at the Calaveras County Jumping Frog Jubilee, and determined jump distance from these images and a calibration of the jump arena. Frogs were divided into two groups: 'rental' frogs collected by fair organizers and jumped by the general public, and frogs collected and jumped by experienced, 'professional' teams. A total of 58% of recorded jumps surpassed the maximum jump distance in the literature (1.295 m), and the longest jump was 2.2 m. Compared with rental frogs, professionally jumped frogs jumped farther, and the distribution of jump distances for this group was skewed towards long jumps. Calculated muscular work, historical records and the skewed distribution of jump distances all suggest that the longest jumps represent the true performance limit for this species. Using resampling, we estimated the probability of observing a given jump distance for various sample sizes, showing that large sample sizes are required to detect rare maximal jumps. These results show the importance of sample size, animal motivation and physiological conditions for accurate maximal performance estimates.

  2. True-breeding targeted gene knock-out in barley using designer TALE-nuclease in haploid cells.

    Directory of Open Access Journals (Sweden)

    Maia Gurushidze

    Full Text Available Transcription activator-like effector nucleases (TALENs are customizable fusion proteins able to cleave virtually any genomic DNA sequence of choice, and thereby to generate site-directed genetic modifications in a wide range of cells and organisms. In the present study, we expressed TALENs in pollen-derived, regenerable cells to establish the generation of instantly true-breeding mutant plants. A gfp-specific TALEN pair was expressed via Agrobacterium-mediated transformation in embryogenic pollen of transgenic barley harboring a functional copy of gfp. Thanks to the haploid nature of the target cells, knock-out mutations were readily detected, and homozygous primary mutant plants obtained following genome duplication. In all, 22% of the TALEN transgenics proved knocked out with respect to gfp, and the loss of function could be ascribed to the deletions of between four and 36 nucleotides in length. The altered gfp alleles were transmitted normally through meiosis, and the knock-out phenotype was consistently shown by the offspring of two independent mutants. Thus, here we describe the efficient production of TALEN-mediated gene knock-outs in barley that are instantaneously homozygous and non-chimeric in regard to the site-directed mutations induced. This TALEN approach has broad applicability for both elucidating gene function and tailoring the phenotype of barley and other crop species.

  3. Statistical Engine Knock Control

    DEFF Research Database (Denmark)

    Stotsky, Alexander A.

    2008-01-01

    A new statistical concept of the knock control of a spark ignition automotive engine is proposed . The control aim is associated with the statistical hy pothesis test which compares the threshold value to the average value of the max imal amplitud e of the knock sensor signal at a given freq uency...

  4. Statistical Engine Knock Control

    DEFF Research Database (Denmark)

    Stotsky, Alexander A.

    2008-01-01

    A new statistical concept of the knock control of a spark ignition automotive engine is proposed . The control aim is associated with the statistical hy pothesis test which compares the threshold value to the average value of the max imal amplitud e of the knock sensor signal at a given freq uency....... C ontrol algorithm which is used for minimization of the regulation error realizes a simple count-up-count-d own logic. A new ad aptation algorithm for the knock d etection threshold is also d eveloped . C onfi d ence interval method is used as the b asis for ad aptation. A simple statistical mod el...

  5. Jumping Dynamics

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2013-01-01

    We propose an alternative paradigm to the conjectured Miransky scaling potentially underlying the physics describing the transition from the conformally broken to the conformally restored phase when tuning certain parameters such as the number of flavors in gauge theories. According to the new...... paradigm the physical scale and henceforth also the massive spectrum of the theory jump at the lower boundary of the conformal window. In particular we propose that a theory can suddenly jump from a Quantum Chromodynamics type spectrum, at the lower boundary of the conformal window, to a conformal one...... without particle interpretation. The jumping scenario, therefore, does not support a near-conformal dynamics of walking type. We will also discuss the impact of jumping dynamics on the construction of models of dynamical electroweak symmetry breaking....

  6. Fairy Tale Autobiographies.

    Science.gov (United States)

    Schulze, Patricia

    Students will work in groups to read and analyze fairy tales, brainstorm for events in their lives that could be changed into fairy tales, develop setting, characters, and plot for their fairy tale, write, illustrate, and compile their fairy tales into group books. During ten 45-minute lessons, students will: choose three fairy tales and read them…

  7. Long Jump

    CERN Document Server

    Dorobantu, V

    2012-01-01

    When the laws of Physics are taken seriously, the sports can benefit in getting better results, as was the case of the high jump in Flop style, so that the athlete sprints diagonally towards the bar,then curve and leap backwards over it. The jumper, in this case, has the center of mass under the bar, fact which allows improvement of the performance.

  8. Genome Editing in Rats Using TALE Nucleases.

    Science.gov (United States)

    Tesson, Laurent; Remy, Séverine; Ménoret, Séverine; Usal, Claire; Thinard, Reynald; Savignard, Chloé; De Cian, Anne; Giovannangeli, Carine; Concordet, Jean-Paul; Anegon, Ignacio

    2016-01-01

    The rat is an important animal model to understand gene function and model human diseases. Since recent years, the development of gene-specific nucleases has become important for generating new rat models of human diseases, to analyze the role of genes and to generate human antibodies. Transcription activator-like (TALE) nucleases efficiently create gene-specific knockout rats and lead to the possibility of gene targeting by homology-directed recombination (HDR) and generating knock-in rats. We describe a detailed protocol for generating knockout and knock-in rats via microinjection of TALE nucleases into fertilized eggs. This technology is an efficient, cost- and time-effective method for creating new rat models.

  9. TALE: a tale of genome editing.

    Science.gov (United States)

    Zhang, Mingjie; Wang, Feng; Li, Shifei; Wang, Yan; Bai, Yun; Xu, Xueqing

    2014-01-01

    Transcription activator-like effectors (TALEs), first identified in Xanthomonas bacteria, are naturally occurring or artificially designed proteins that modulate gene transcription. These proteins recognize and bind DNA sequences based on a variable numbers of tandem repeats. Each repeat is comprised of a set of ∼ 34 conserved amino acids; within this conserved domain, there are usually two amino acids that distinguish one TALE from another. Interestingly, TALEs have revealed a simple cipher for the one-to-one recognition of proteins for DNA bases. Synthetic TALEs have been used to successfully target genes in a variety of species, including humans. Depending on the type of functional domain that is fused to the TALE of interest, these proteins can have diverse biological effects. For example, after binding DNA, TALEs fused to transcriptional activation domains can function as robust transcription factors (TALE-TFs), while fused to restriction endonucleases (TALENs) can cut DNA. Targeted genome editing, in theory, is capable of modifying any endogenous gene sequence of interest; this can be performed in cells or organisms, and may be applied to clinical gene-based therapies in the future. With current technologies, highly accurate, specific, and reliable gene editing cannot be achieved. Thus, recognition and binding mechanisms governing TALE biology are currently hot research areas. In this review, we summarize the major advances in TALE technology over the past several years with a focus on the interaction between TALEs and DNA, TALE design and construction, potential applications for this technology, and unique characteristics that make TALEs superior to zinc finger endonucleases.

  10. Modern Baltic fairy tales in drama / Anneli Saro

    Index Scriptorium Estoniae

    Saro, Anneli, 1968-

    2009-01-01

    Jaan Tätte näidendist "Ristumine peateega, ehk, Muinasjutt kuldsest kalakesest" ("The highway crossing, or, The tale of a golden fish", tuntud ka pealkirjaga "Bungee jumping" ) ja Inga Ābele näidendist "Tumedad hirved" (The dark deer")

  11. Modern Baltic fairy tales in drama / Anneli Saro

    Index Scriptorium Estoniae

    Saro, Anneli, 1968-

    2009-01-01

    Jaan Tätte näidendist "Ristumine peateega, ehk, Muinasjutt kuldsest kalakesest" ("The highway crossing, or, The tale of a golden fish", tuntud ka pealkirjaga "Bungee jumping" ) ja Inga Ābele näidendist "Tumedad hirved" (The dark deer")

  12. Fairy Tales from Life.

    Science.gov (United States)

    Schulze, Patricia

    With the help of the teacher, students will read fairy tales and identify common elements. Choosing common situations and working in small groups, students will draw storyboards of their fairy tale and then write the fairy tale. Project will conclude with class presentations. During ten 50-minute lessons, grade 3-5 students will: listen and read…

  13. Richard Halliburton's Bearded Tales

    Science.gov (United States)

    Morris, Charles E., III

    2009-01-01

    Fusing the concept of "the beard" with the genre of the tall tale to theorize bearded tales deepens our understanding of closet eloquence, or rhetorical repertories of sexual passing in U.S. history. An examination of adventurer-writer-lecturer Richard Halliburton's sexual provenance and bestselling travel tale, "The Royal Road to Romance" (1925),…

  14. Revisiting the TALE repeat.

    Science.gov (United States)

    Deng, Dong; Yan, Chuangye; Wu, Jianping; Pan, Xiaojing; Yan, Nieng

    2014-04-01

    Transcription activator-like (TAL) effectors specifically bind to double stranded (ds) DNA through a central domain of tandem repeats. Each TAL effector (TALE) repeat comprises 33-35 amino acids and recognizes one specific DNA base through a highly variable residue at a fixed position in the repeat. Structural studies have revealed the molecular basis of DNA recognition by TALE repeats. Examination of the overall structure reveals that the basic building block of TALE protein, namely a helical hairpin, is one-helix shifted from the previously defined TALE motif. Here we wish to suggest a structure-based re-demarcation of the TALE repeat which starts with the residues that bind to the DNA backbone phosphate and concludes with the base-recognition hyper-variable residue. This new numbering system is consistent with the α-solenoid superfamily to which TALE belongs, and reflects the structural integrity of TAL effectors. In addition, it confers integral number of TALE repeats that matches the number of bound DNA bases. We then present fifteen crystal structures of engineered dHax3 variants in complex with target DNA molecules, which elucidate the structural basis for the recognition of bases adenine (A) and guanine (G) by reported or uncharacterized TALE codes. Finally, we analyzed the sequence-structure correlation of the amino acid residues within a TALE repeat. The structural analyses reported here may advance the mechanistic understanding of TALE proteins and facilitate the design of TALEN with improved affinity and specificity.

  15. Risk, Jumps, and Diversification

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Law, Tzuo Hann; Tauchen, George

    We test for price discontinuities, or jumps, in a panel of high-frequency intraday returns for forty large-cap stocks and an equiweighted index from these same stocks. Jumps are naturally classified into two types: common and idiosyncratic. Common jumps affect all stocks, albeit to varying degree...

  16. Jumping in Arithmetic

    NARCIS (Netherlands)

    Visser, Albert

    2014-01-01

    In this paper we study a new relation between sentences: the jump relation. The idea of the jump relation is based on an analysis of Feferman's Theorem that the inconsistency of a theory U is interpretable over U. The jump relation is based on a converse of Feferman's Theorem: if a sentence is inter

  17. Tall Tales on Tour.

    Science.gov (United States)

    Renaud, Linda; Silk, Lynn

    "Tall Tales on Tour" consists of a mobile unit of books, posters, puppets, plays, videos, teachers' guides and other resources designed to kindle enthusiasm and love for tall tales in students in grades 3-8 and to establish links with rural Washington County, Maine, schools. The program consists of three main components: (1) immersing…

  18. Tale til himlen

    DEFF Research Database (Denmark)

    Thau, Carsten

    2004-01-01

    Bidrag til udstillingskatalog til udstillingen 'Tale til himlen : Torben Ebbesen' i Kunsthallen Brænderigaarden, Viborg 28. maj - 15. august 2004......Bidrag til udstillingskatalog til udstillingen 'Tale til himlen : Torben Ebbesen' i Kunsthallen Brænderigaarden, Viborg 28. maj - 15. august 2004...

  19. Lost Opportunities: Rediscovering Fairy Tales

    Science.gov (United States)

    Wipf, Joan Brogan; Da Ros-Voseles, Denise

    2012-01-01

    The power of fairy tales resonates with children around the world. Fairy tales connect children on an emotional level that can help guide them through the complexities of everyday life. The tales provide stories rich in cultural heritage and the human condition, stories that not only delight children but also instruct. Because fairy tales state…

  20. Steerable Miniature Jumping Robot

    OpenAIRE

    Kovac, Mirko; Schlegel, Manuel; Zufferey, Jean-Christophe; Floreano, Dario

    2010-01-01

    Jumping is used in nature by many small animals to locomote in cluttered environments or in rough terrain. It offers small systems the benefit of overcoming relatively large obstacles at a low energetic cost. In order to be able to perform repetitive jumps in a given direction, it is important to be able to upright after landing, steer and jump again. In this article, we review and evaluate the uprighting and steering principles of existing jumping robots and present a novel spherical robot w...

  1. Optimal Ski Jump

    Science.gov (United States)

    Rebilas, Krzysztof

    2013-01-01

    Consider a skier who goes down a takeoff ramp, attains a speed "V", and jumps, attempting to land as far as possible down the hill below (Fig. 1). At the moment of takeoff the angle between the skier's velocity and the horizontal is [alpha]. What is the optimal angle [alpha] that makes the jump the longest possible for the fixed magnitude of the…

  2. Jumping Good Fun

    Science.gov (United States)

    Nye, Susan B.

    2010-01-01

    Jumping rope is an activity that can be fun and enjoyable for all students. It requires minimal activity space, can be performed individually or in small groups, and is an inexpensive way to engage students in a lifelong physical activity. Jumping rope is commonly used by coaches and athletes for training purposes to improve aerobic endurance,…

  3. Jumping Good Fun

    Science.gov (United States)

    Nye, Susan B.

    2010-01-01

    Jumping rope is an activity that can be fun and enjoyable for all students. It requires minimal activity space, can be performed individually or in small groups, and is an inexpensive way to engage students in a lifelong physical activity. Jumping rope is commonly used by coaches and athletes for training purposes to improve aerobic endurance,…

  4. Estimation of Jump Tails

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Todorov, Victor

    We propose a new and flexible non-parametric framework for estimating the jump tails of Itô semimartingale processes. The approach is based on a relatively simple-to-implement set of estimating equations associated with the compensator for the jump measure, or its "intensity", that only utilizes ...

  5. Tales of Accreditation Woe.

    Science.gov (United States)

    Dickmeyer, Nathan

    2002-01-01

    Offers cautionary tales depicting how an "Enron mentality" infiltrated three universities and jeopardized their accreditation status. The schools were guilty, respectively, of bad bookkeeping, lack of strategy and stable leadership, and loss of academic integrity by selling degrees. (EV)

  6. The TALE Infill Array

    Science.gov (United States)

    Bergman, Douglas

    2009-05-01

    The TALE Infill Array in conjunction with the TALE Tower Detector will provide hybrid coverage of the cosmic ray energy spectrum down to 3x10^16 eV. It will consist of about 100, two square meter scintillators on the surface spaced at 400 m; and 24 buried twelve square meter scintillators. The combination of surface and underground detectors will allow for the determination of the muon content of showers and thus give a handle on cosmic ray composition.

  7. The Legend of Jump Mountain: Narrative Dispossession of the Monacan in Postcolonial Virginia

    Science.gov (United States)

    Vest, Jay Hansford C.

    2012-01-01

    In north central Virginia there is a local tale--The Legend of Jump Mountain, which purports to explain the origins of the Hayes Creek Indian Burial Mound. A highly romantic legend, it immortalizes post colonial intertribal warfare during the early nineteenth century while ignoring the antiquity of the mound and the local descendants of its…

  8. Quantum Walk with Jumps

    CERN Document Server

    Lavička, H; Kiss, T; Lutz, E; Jex, I

    2011-01-01

    We analyze a special class of 1-D quantum walks (QWs) realized using optical multi-ports. We assume non-perfect multi-ports showing errors in the connectivity, i.e. with a small probability the multi- ports can connect not to their nearest neighbor but to another multi-port at a fixed distance - we call this a jump. We study two cases of QW with jumps where multiple displacements can emerge at one timestep. The first case assumes time-correlated jumps (static disorder). In the second case, we choose the positions of jumps randomly in time (dynamic disorder). The probability distributions of position of the QW walker in both instances differ significantly: dynamic disorder leads to a Gaussian-like distribution, while for static disorder we find two distinct behaviors depending on the parity of jump size. In the case of even-sized jumps, the distribution exhibits a three-peak profile around the position of the initial excitation, whereas the probability distribution in the odd case follows a Laplace-like discre...

  9. Jumping on water

    Science.gov (United States)

    Kim, Ho-Young

    2016-11-01

    Water striders can jump on water as high as they can jump on land. Quick jumps allow them to avoid sudden dangers such as predators' attacks, and therefore understanding how they make such a dramatic motion for survival can shed light on the ultimate level of semi-aquatic motility achievable through evolution. However, the mechanism of their vertical jumping from a water surface has eluded hydrodynamic explanations so far. By observing movements of water strider legs and theoretically analyzing their dynamic interactions with deforming liquid-air interface, we have recently found that different species of jumping striders always tune their leg rotation speed with a force just below that required to break the water surface to reach the maximum take-off velocity. Here, we start with discussing the fundamental theories of dynamics of floating and sinking of small objects. The theories then enable us to analyze forces acting on a water strider while it presses down the water surface to fully exploit the capillary force. We further introduce a 68-milligram at-scale robotic insect capable of jumping on water without splash, strikingly similar to the real strider, by utilizing the water surface just as a trampoline.

  10. Twisters, Tall Tales, & Science Teaching

    Science.gov (United States)

    Wilcox, Dawn Renee; Sterling, Donna R.

    2006-01-01

    Legends and tall tales have been part of the American culture for ages. Students are probably already familiar with the tales of how Pecos Bill fearlessly tamed a ferocious tornado, or Paul Bunyan effortlessly restrained a great river. Such tales have been passed down from generation to generation to explain humanity, the natural world, and…

  11. The TALE Tower Detector

    Science.gov (United States)

    Bergman, D. R.

    The TA Low Energy Extension will include a Tower FluorescenceDetector. Extensive air showers at the lowest usful energies for fluorescence detectors will in general be close to the detector. This requires viewing all elevation angles to be able to reconstruct showers. The TALE Tower Detector, operating in conjunction with other TALE detectors will view elevation angles up to above 70 degrees, with an azimuthal coverage of about 90 degrees. Results from a prototype mirror operated in conjunction with the HiRes detector will also be presented.

  12. Technology and Fairy Tales

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    2005-01-01

    The Danish writer Hans Christian Andersen was born 200 years ago and lived in a time of enormous progress in technology and science. He was excited about this, but also worried about what they would do to humans and culture. This dilemma is expressed in some of Andersen's fairy tales, here illust...

  13. Technology and Fairy Tales

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    2005-01-01

    The Danish writer Hans Christian Andersen was born 200 years ago and lived in a time of enormous progress in technology and science. He was excited about this, but also worried about what they would do to humans and culture. This dilemma is expressed in some of Andersen's fairy tales, here...

  14. Spinning hydraulic jump

    Science.gov (United States)

    Abderrahmane, Hamid; Kasimov, Aslan

    2013-11-01

    We report an experimental observation of a new symmetry breaking of circular hydraulic jump into a self-organized structure that consists of a spinning polygonal jump and logarithmic-spiral waves of fluid elevation downstream. The waves are strikingly similar to spiral density waves in galaxies. The fluid flow exhibits counterparts of salient morphological features of galactic flows, in particular the outflow from the center, jets, circum-nuclear rings, gas inflows toward the galactic center, and vortices. The hydrodynamic instability revealed here may have a counterpart that plays a role in the formation and sustainability of spiral arms in galaxies.

  15. 16 tales of innovation

    DEFF Research Database (Denmark)

    16 Tales of Innovation are told by 16 leaders, who have completed the LAICS executive master program, a collaboration between Aarhus University and Copenhagen Business School. The book is based on their Master theses and illustrates how they have experimented with different innovation tools, mode...... and innovation theories within their own organization. Here they share their unique insights into the processes, methods and the impact of their academic work with innovation in practice....

  16. On Reality, Truth and Ideologies in the Case of Munchausen Tales

    Directory of Open Access Journals (Sweden)

    Eda Kalmre

    2013-04-01

    Full Text Available This article studies the way the meaning of a tradition has changed over time. It is based on four text samples, all representing similar motives. The story reflects a former popular belief that if you hold on to a wild animal’s tail, the animal will jump clean out of its skin. The Man Nails the Tail of a Wolf to a Tree (ATU 1896 is a popular folk tale with an international distribution. Texts of this type have also been called Munchausen tales. The changed message of similar traditions reflects the change in our attitude towards nature, but also the growing distance of man from nature.

  17. Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

    Science.gov (United States)

    Neto, João Luís; Lee, Jong-Min; Afridi, Ali; Gillis, Tammy; Guide, Jolene R.; Dempsey, Stephani; Lager, Brenda; Alonso, Isabel; Wheeler, Vanessa C.; Pinto, Ricardo Mouro

    2017-01-01

    Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the HTT gene. Longer repeat sizes are associated with increased disease penetrance and earlier ages of onset. Intergenerationally unstable transmissions are common in HD families, partly underlying the genetic anticipation seen in this disorder. HD CAG knock-in mouse models also exhibit a propensity for intergenerational repeat size changes. In this work, we examine intergenerational instability of the CAG repeat in over 20,000 transmissions in the largest HD knock-in mouse model breeding datasets reported to date. We confirmed previous observations that parental sex drives the relative ratio of expansions and contractions. The large datasets further allowed us to distinguish effects of paternal CAG repeat length on the magnitude and frequency of expansions and contractions, as well as the identification of large repeat size jumps in the knock-in models. Distinct degrees of intergenerational instability were observed between knock-in mice of six background strains, indicating the occurrence of trans-acting genetic modifiers. We also found that lines harboring a neomycin resistance cassette upstream of Htt showed reduced expansion frequency, indicative of a contributing role for sequences in cis, with the expanded repeat as modifiers of intergenerational instability. These results provide a basis for further understanding of the mechanisms underlying intergenerational repeat instability. PMID:27913616

  18. Undular Hydraulic Jump

    Directory of Open Access Journals (Sweden)

    Oscar Castro-Orgaz

    2015-04-01

    Full Text Available The transition from subcritical to supercritical flow when the inflow Froude number Fo is close to unity appears in the form of steady state waves called undular hydraulic jump. The characterization of the undular hydraulic jump is complex due to the existence of a non-hydrostatic pressure distribution that invalidates the gradually-varied flow theory, and supercritical shock waves. The objective of this work is to present a mathematical model for the undular hydraulic jump obtained from an approximate integration of the Reynolds equations for turbulent flow assuming that the Reynolds number R is high. Simple analytical solutions are presented to reveal the physics of the theory, and a numerical model is used to integrate the complete equations. The limit of application of the theory is discussed using a wave breaking condition for the inception of a surface roller. The validity of the mathematical predictions is critically assessed using physical data, thereby revealing aspects on which more research is needed

  19. A cautionary holiday tale.

    Science.gov (United States)

    Wickham, Sara

    2015-12-01

    In this column, Sara Wickham takes a sideways look at issues relevant to midwives, students, women and families, inviting us to sit down with a cup of tea and ponder what we think we know. This month's seasonal story tells the tale of Rudolph the red-nosed quantity surveyor, who gets more than he has bargained for when he visits the labour ward in order to weigh the birth balls for a trust health and safety exercise and decides to make tea for the tired midwives....

  20. Deconstructing Gender in Revised Feminist Fairy Tales

    Science.gov (United States)

    Mcandrew, Linda

    2013-01-01

    Power relationships are a central premise in children's literature, especially traditional fairy tales and modern feminist fairy tales. This is seen in many fairy tales where the main female character is in some distress, her Prince Charming rescues her, and they live happily ever after. Modern feminist fairy tales are understood to be a forum…

  1. Yee-e-e-Haw!: Tall Tales.

    Science.gov (United States)

    Jordan, Anne Devereaux

    1997-01-01

    Outlines the characteristics of "tall tales." Fills in the historical background of tall tales, from the ancient myth of Gilgamesh to Baron Munchausen, the closest European progenitor of American tall tales. Opines that tall tales appear to have been created as a response to challenges posed by building a new nation. Lists 11…

  2. The TALE Fluorescence Detectors

    Science.gov (United States)

    Jui, Charles

    2009-05-01

    The TALE fluorescence detectors are designed to extend the threshold for fluorescence observation by TA down to 3x10^16 eV. It will comprise two main components. The first is a set of 24 telescopes working in stereo, with an existing TA FD station at ˜6 km separation. These will cover between 3-31 degrees in elevation and have azimuthal coverage maximizing the stereo aperture in the 10^18-10^19 eV energy range. The second component consists of 15 telescopes equipped with 4m diameter mirrors and covering the sky between 31 and 73 degrees in elevation. The larger mirror size pushes the physics threshold down to 3x10^16 eV, and provides view of the shower maximum for the lower energy events. The Tower detector will cover one quadrant in azimuth and operate in hybrid mode with the TALE infill array to provide redundant composition measurements from both shower maximum information and muon-to-electron ratio.

  3. Ridge jump process in Iceland

    OpenAIRE

    Garcia, Sebastian

    2010-01-01

    Eastward ridge jumps bring the volcanic zones of Iceland back to the centre of the hotspot in response to the absolute westward drift of the Mid-Atlantic Ridge. Mantellic pulses triggers these ridge jumps. One of them is occurring in Southern Iceland, whereas the exact conditions of the last ridge jump in Northern Iceland remain controversial. The diachronous evolution of these two parts of Iceland may be related to the asymmetric plume-ridge interaction when comparing Northern and Southern I...

  4. and the CMJ jump height

    Directory of Open Access Journals (Sweden)

    Struzik Artur

    2016-04-01

    Full Text Available Study aim: The elastic potential energy accumulated in the musculotendinous units during the countermovement phase of a jump adds up to the energy supplied by the contracting muscles used in the take-off phase. Consequently, the total mechanical energy used during the jump may reach higher values. Stiffness represents a quantitative measure of a body’s elastic properties. Therefore, the aim of this study was to establish the relationship between leg stiffness and the countermovement jump height.

  5. Exploring Lightning Jump Characteristics

    Science.gov (United States)

    Chronis, Themis; Carey, Larry D.; Schultz, Christopher J.; Schultz, Elise; Calhoun, Kristin; Goodman, Steven J.

    2014-01-01

    This study is concerned with the characteristics of storms exhibiting an abrupt temporal increase in the total lightning flash rate (i.e., lightning jump, LJ). An automated storm tracking method is used to identify storm "clusters" and total lightning activity from three different lightning detection systems over Oklahoma, northern Alabama and Washington, D.C. On average and for different employed thresholds, the clusters that encompass at least one LJ (LJ1) last longer, relate to higher Maximum Expected Size of Hail, Vertical Integrated Liquid and lightning flash rates (area-normalized) than the clusters that did not exhibit any LJ (LJ0). The respective mean values for LJ1 (LJ0) clusters are 80 min (35 min), 14 mm (8 mm), 25 kg per square meter (18 kg per square meter) and 0.05 flash per min per square kilometer (0.01 flash per min per square kilometer). Furthermore, the LJ1 clusters are also characterized by slower decaying autocorrelation functions, a result that implies a less "random" behavior in the temporal flash rate evolution. In addition, the temporal occurrence of the last LJ provides an estimate of the time remaining to the storm's dissipation. Depending of the LJ strength (i.e., varying thresholds), these values typically range between 20-60 min, with stronger jumps indicating more time until storm decay. This study's results support the hypothesis that the LJ is a proxy for the storm's kinematic and microphysical state rather than a coincidental value.

  6. More Puddle Jumping

    Science.gov (United States)

    Attari, Babak; Weislogel, Mark; Wollman, Andrew; Chen, Yongkang; Snyder, Trevor

    2016-11-01

    Large droplets and puddles jump spontaneously from sufficiently hydrophobic surfaces during routine drop tower tests. The simple low-cost passive mechanism can in turn be used as an experimental device to investigate dynamic droplet phenomena for drops up to 10,000 times larger than their normal terrestrial counterparts. We provide or confirm quick and qualitative design guides for such 'drop shooters' as employed in drop tower tests including relationships to predict droplet ejection durations and velocities as functions of drop volume, surface texture, surface contour, wettability pattern, drop volume, and fluid properties including contact angle. The latter are determined via profile image comparisons with numerical equilibrium interface computations. Water drop volumes of 0.04 to 400 mL at ejection speeds of -0.007 to 0.12 m/s are demonstrated. An example application of the puddle jump method is made to the classic problem of regime mapping for low-gravity phase change heat transfer for large impinging drops. Many other candidate problems might be identified.

  7. Tales from the future

    DEFF Research Database (Denmark)

    Mortensen, Janne Reffstrup; Henriksen, Kristoffer; Stelter, Reinhard

    2013-01-01

    in the overall athletic career. The present study is a qualitative inquiry using semi-structured interviews as data. We asked eight young and very talented athletes to imagine they were at the end of a successful career in their chosen sport and invited them to describe how they got there. The qualitative...... interview strategy was narrative in its attempt to elicit how the young athletes made meaning of their endeavors through narratives and biographical in its attempt to ask the athletes to describe their future career paths. We analyzed the interviews as single case studies, subjected them to meaning...... condensation and then constructed the final narratives. Common features of the tales pertain to the fact that these athletes are still young and have yet to grasp the reality of what they are embarking on, which is clear from the simplicity and lightness that is portrayed in their perspectives. The athletes...

  8. Tales of Tourism

    DEFF Research Database (Denmark)

    Smed, Karina Madsen

    2011-01-01

    Tales of Tourism - Global Changes and tourism discourse by Karina Smed presents us with what has been the dominant discourse of tourism, i.e. a discourse which has had its roots in the West's economic and cultural hegemony and the problem of the formation of identity from the dichotomy "self......" and the "others". The author discusses to which extent tourism discourse is global as the reception of it has been different depending on the context. Moreover, she reflects on the impact upon this global narrative that the new economic world order will have. The new and emergent economies lead to a flow...... of tourists in the opposite direction: from China, India and Russia to western countries and worldwide and this will probably change the concept of tourism and our idea of identities....

  9. Tales of Tourism

    DEFF Research Database (Denmark)

    Smed, Karina Madsen

    2011-01-01

    Tales of Tourism - Global Changes and tourism discourse by Karina Smed presents us with what has been the dominant discourse of tourism, i.e. a discourse which has had its roots in the West's economic and cultural hegemony and the problem of the formation of identity from the dichotomy "self......" and the "others". The author discusses to which extent tourism discourse is global as the reception of it has been different depending on the context. Moreover, she reflects on the impact upon this global narrative that the new economic world order will have. The new and emergent economies lead to a flow...... of tourists in the opposite direction: from China, India and Russia to western countries and worldwide and this will probably change the concept of tourism and our idea of identities....

  10. Foghs glemte tale

    DEFF Research Database (Denmark)

    Holtermann, Jakob von Holderstein

    2007-01-01

    De fraværende masseødelæggelsesvåben i Irak har fået statsministeren til at påstå at Danmark havde en ganske særlig begrundelse for at gå i krig: mens resten af koalitionen gjorde det fordi Saddam truede vores sikkerhed, gjorde vi det alene fordi han ikke samarbejde med FN. Jeg viser at denne pås...... påstand er usand. Vores (officielle) grunde var præcis de samme som USA og Storbritannien. Det fremgår af den tale han holdt henvendt til den danske befolkning bare 15 minutter efter krigsbeslutningen var taget....

  11. Hydraulic jumps in a channel

    DEFF Research Database (Denmark)

    Bonn, D.; Andersen, Anders Peter; Bohr, Tomas

    2009-01-01

    We present a study of hydraulic jumps with flow predominantly in one direction, created either by confining the flow to a narrow channel with parallel walls or by providing an inflow in the form of a narrow sheet. In the channel flow, we find a linear height profile upstream of the jump as expected...

  12. Occupational health in fairy tales.

    Science.gov (United States)

    Rivolta, Alice; Arienti, Federica; Smith, Derek R; Cesana, Giancarlo; Riva, Michele A

    2016-05-03

    Myths and folklore, as expressions of popular beliefs, provide valuable information on medical knowledge in earlier times. Fairy tales have often recounted occupational maladies throughout the ages and also provide some insight into the toxic effects of certain metals, such as mercury. Much historical information can be gleaned from unexpected sources, and as such, fairy tales should be more carefully scrutinized by contemporary researchers with an interest in the historical origins of workplace injury and disease.

  13. Electrostatic charging of jumping droplets

    Science.gov (United States)

    Miljkovic, Nenad; Preston, Daniel J.; Enright, Ryan; Wang, Evelyn N.

    2013-09-01

    With the broad interest in and development of superhydrophobic surfaces for self-cleaning, condensation heat transfer enhancement and anti-icing applications, more detailed insights on droplet interactions on these surfaces have emerged. Specifically, when two droplets coalesce, they can spontaneously jump away from a superhydrophobic surface due to the release of excess surface energy. Here we show that jumping droplets gain a net positive charge that causes them to repel each other mid-flight. We used electric fields to quantify the charge on the droplets and identified the mechanism for the charge accumulation, which is associated with the formation of the electric double layer at the droplet-surface interface. The observation of droplet charge accumulation provides insight into jumping droplet physics as well as processes involving charged liquid droplets. Furthermore, this work is a starting point for more advanced approaches for enhancing jumping droplet surface performance by using external electric fields to control droplet jumping.

  14. Jump conditions in transonic equilibria

    Energy Technology Data Exchange (ETDEWEB)

    Guazzotto, L.; Betti, R. [Department of Mechanical Engineering, University of Rochester, Rochester, New York 14627 (United States); Jardin, S. C. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08540 (United States)

    2013-04-15

    In the present paper, the numerical calculation of transonic equilibria, first introduced with the FLOW code in Guazzotto et al.[Phys. Plasmas 11, 604 (2004)], is critically reviewed. In particular, the necessity and effect of imposing explicit jump conditions at the transonic discontinuity are investigated. It is found that 'standard' (low-{beta}, large aspect ratio) transonic equilibria satisfy the correct jump condition with very good approximation even if the jump condition is not explicitly imposed. On the other hand, it is also found that high-{beta}, low aspect ratio equilibria require the correct jump condition to be explicitly imposed. Various numerical approaches are described to modify FLOW to include the jump condition. It is proved that the new methods converge to the correct solution even in extreme cases of very large {beta}, while they agree with the results obtained with the old implementation of FLOW in lower-{beta} equilibria.

  15. Fairy-tales in psychotherapy.

    Science.gov (United States)

    Dieckmann, H

    1997-04-01

    Fairy-tales, like mythologies, can be found all over the world containing the same motif and chains of motifs. In this paper I have presented some theories on the occurrence of this archetypal phenomenon ranging from the old migration theory to Sheldrake's theory of morphogenetic fields. I have then tried to show how fairy-tale-motifs can appear in various ways in analytical therapy, often in hidden forms. We find them in patients' dreams as well as in their fantasies and associations. If the therapist is open to them they will also appear in his or her amplifications. He or she might then take note of the fairy-tale or point it out to the patient; in the latter case it might provide better access to the patient's problems and complexes as fairy-tales have an emotional completeness because of their pictorial character. Finally I have described the favourite fairy-tale of one of my patients and related it to his symptoms, his central complex and his personal ways of experiencing and behaving. This survey of how fairy-tales can be used in therapy with children and with adults far from exhaustive.

  16. Choice of jumping strategy in two standard jumps, squat and countermovement jump--effect of training background or inherited preference?

    DEFF Research Database (Denmark)

    Ravn, Susanne; Voigt, M; Simonsen, Erik Bruun

    1999-01-01

    Six male subjects, three professional ballet dancers and three elite volleyball players, performed maximal vertical jumps from 1) a static preparatory position (squat jump), 2) starting with a countermovement (countermovement jump) and 3) a specific jump for ballet and for volleyball, respectively....... The jumps were recorded on highspeed film (500 Hz) combined with registration of ground reaction forces, and net joint moments were calculated by inverse dynamics. The purpose was to investigate the choice of strategy in two standard jumps, squat jump and countermovement jump. The volleyball jump...... was performed with a sequential strategy and the ballet jump was performed with a simultaneous strategy. In the two standard jumps, the choice of strategy was individual and not related to training background. This was additionally confirmed in a test of seven ballet dancers and seven volleyball players....

  17. Frequency Jump Detection and Analysis

    Science.gov (United States)

    2008-12-01

    CUMULATIVE SUM JUMP DETECTION The Cumulative Sum ( CUSUM ) is a classic change-point analysis technique that uses the cumulative sum of the...sum and y is the average of the data. The CUSUM slope indicates the value of the data with respect to the overall average. A flat cumulative sum...sudden change in the CUSUM slope indicates a jump in the data. The CUSUM plot for a data set having a single jump will have a V or inverted V shape

  18. Realized Jump Risk and Equity Return in China

    OpenAIRE

    Guojin Chen; Xiaoqun Liu; Peilin Hsieh; Xiangqin Zhao

    2014-01-01

    We utilize the realized jump components to explore a new jump (including nonsystematic jump and systematic jump) risk factor model. After estimating daily realized jumps from high-frequency transaction data of the Chinese A-share stocks, we calculate monthly jump size, monthly jump standard deviation, and monthly jump arrival rate and then use those monthly jump factors to explain the return of the following month. Our empirical results show that the jump tail risk can explain the equity retu...

  19. Rook Jumping Maze Design Considerations

    Science.gov (United States)

    Neller, Todd W.; Fisher, Adrian; Choga, Munyaradzi T.; Lalvani, Samir M.; McCarty, Kyle D.

    We define the Rook Jumping Maze, provide historical perspective, and describe a generation method for such mazes. When applying stochastic local search algorithms to maze design, most creative effort concerns the definition of an objective function that rates maze quality. We define and discuss several maze features to consider in such a function definition. Finally, we share our preferred design choices, make design process observations, and note the applicability of these techniques to variations of the Rook Jumping Maze.

  20. Fairy Tales around the World. [Lesson Plan].

    Science.gov (United States)

    2002

    Fairy tales are stories either created or strongly influenced by oral traditions. Their plots feature stark conflicts between good and evil, with magic and luck determining the usually happy endings. While each culture and geographic region of the world has its own body of folk tales and fairy tales, certain themes and motifs tend to be repeated…

  1. The Effect of Depth Jumps and Weight Training on Leg Strength and Vertical Jump.

    Science.gov (United States)

    Clutch, David; And Others

    1983-01-01

    Two experiments examined the results of depth jumping programs to determine: (1) whether certain depth jumping routines, when combined with weight training, are better than others; and (2) the effect of depth jumping on athletes already in training. Results indicated that depth jumping is effective, but no more so than regular jumping routines.…

  2. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    Science.gov (United States)

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in knowing about it and…

  3. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    Science.gov (United States)

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in…

  4. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    Science.gov (United States)

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in…

  5. Test-retest reliability of jump execution variables using mechanography: A comparison of jump protocols

    Science.gov (United States)

    Mechanography during the vertical jump test allows for evaluation of force-time variables reflecting jump execution, which may enhance screening for functional deficits that reduce physical performance and determining mechanistic causes underlying performance changes. However, utility of jump mechan...

  6. Medieval Food for Canterbury Tales

    OpenAIRE

    Mac Con Iomaire, Máirtín; Zaidan, Patrick; Danaher, Pauline; Farrell, Mark; Cawley, Diarmuid; Fox, James

    2015-01-01

    This report give a brief outline of the planing and the execution of medieval food for the DIT's production of the Canterbury Tales on 11-14 March 2015 in Smock Alley Theatre, Dublin - a collaboration between the DIT Conservatory of Music and Drama and the School of Culinary Arts & Food Technology.

  7. Tales of Mystery and Imagination

    NARCIS (Netherlands)

    Poe, Edgar Allan

    2005-01-01

    Some of the most exciting and haunting stories ever written are to be found in this collection of Poe's work, ranging from the poetic to the mysterious to the darkly comic, and all with the quality of the grotesque that defined Poe's writing. 'The Tell-Tale Heart' and 'The Fall of the House of

  8. "Arabian Tales": Standards of Learning.

    Science.gov (United States)

    Brookshire, Cathy A.

    Virginia Standards of Learning for K-5 are listed in this paper with student activities related to observation of live theatre performances of "Arabian Tales" written and performed by the high school theater touring company, Organized Chaos. This play toured in Virginia in the academic year of 2000-2001. The play runs about 45 minutes.…

  9. Tales of Mystery and Imagination

    NARCIS (Netherlands)

    Poe, Edgar Allan

    2005-01-01

    Some of the most exciting and haunting stories ever written are to be found in this collection of Poe's work, ranging from the poetic to the mysterious to the darkly comic, and all with the quality of the grotesque that defined Poe's writing. 'The Tell-Tale Heart' and 'The Fall of the House of Usher

  10. A Tale of TWO WORLDS

    Institute of Scientific and Technical Information of China (English)

    Gerard Lyons

    2010-01-01

    @@ The global economy is currently a tale of two worlds.A buoyant East contrasts with a fragile West.The difference is highlighted not just in the economic data but also in the monetary policies being pursued around the globe.

  11. A Tale of Two Cities

    NARCIS (Netherlands)

    Dickens, Charles

    2005-01-01

    A Tale of Two Cities is one of Dickens's most exciting books, set against the backdrop of the French revolution, in which two generations struggle against the injustices of first a corrupt aristocracy and then the mindless rule of the mob.

  12. A Tale of Four Electrons

    Science.gov (United States)

    Burgmayer, Paul

    2011-01-01

    "A Tale of Four Electrons" is a creative writing assignment used with 10th-grade Honors Chemistry students. The project helps students consolidate their learning about bonding--an important unifying theme in chemistry--and answers questions such as (1) How are ionic, metallic, and covalent bonds related? (2) How do variations in electron…

  13. Learning through a Winter's Tale

    Science.gov (United States)

    Vidotto, Kristie

    2010-01-01

    In this article, the author shares her experience during the final semester of Year 11 Theatre Studies when she performed a monologue about Hermione from "The Winter's Tale". This experience was extremely significant to her because it nearly made her lose faith in one of the most important parts of her life, drama. She believes this experience,…

  14. Gravity current jump conditions, revisited

    Science.gov (United States)

    Ungarish, Marius; Hogg, Andrew J.

    2016-11-01

    Consider the flow of a high-Reynolds-number gravity current of density ρc in an ambient fluid of density ρa in a horizontal channel z ∈ [ 0 , H ] , with gravity in - z direction. The motion is often modeled by a two-layer formulation which displays jumps (shocks) in the height of the interface, in particular at the leading front of the dense layer. Various theoretical models have been advanced to predict the dimensionless speed of the jump, Fr = U /√{g' h } ; g' , h are reduced gravity and jump height. We revisit this problem and using the Navier-Stokes equations, integrated over a control volume embedding the jump, derive balances of mass and momentum fluxes. We focus on understanding the closures needed to complete this model and we show the vital need to understand the pressure head losses over the jump, which we show can be related to the vorticity fluxes at the boundaries of the control volume. Our formulation leads to two governing equations for three dimensionless quantities. Closure requires one further assumption, depending on which we demonstrate that previous models for gravity current fronts and internal bores can be recovered. This analysis yield new insights into existing results, and also provides constraints for potential new formulae.

  15. Coalescence-induced nanodroplet jumping

    Science.gov (United States)

    Cha, Hyeongyun; Xu, Chenyu; Sotelo, Jesus; Chun, Jae Min; Yokoyama, Yukihiro; Enright, Ryan; Miljkovic, Nenad

    2016-10-01

    Water vapor condensation on superhydrophobic surfaces has received much attention in recent years due to the ability of such surfaces to shed microscale water droplets via coalescence-induced droplet jumping, resulting in heat transfer, anti-icing, and self-cleaning performance enhancement. Here we report the coalescence-induced removal of water nanodroplets (R ≈500 nm ) from superhydrophobic carbon nanotube (CNT) surfaces. The two-droplet coalescence time is measured for varying droplet Ohnesorge numbers, confirming that coalescence prior to jumping is governed by capillary-inertial dynamics. By varying the conformal hydrophobic coating thickness on the CNT surface, the minimum jumping droplet radius is shown to increase with increasing solid fraction and decreasing apparent advancing contact angle, allowing us to explore both hydrodynamic limitations stemming from viscous dissipation and surface adhesion limitations. We find that, even for the smallest nanostructure length scale (≤100 nm) and lowest surface adhesions, nonideal surface interactions and the evolved droplet morphology play defining roles in limiting the minimum size for jumping on real surfaces. The outcomes of this work demonstrate the ability to passively shed nanometric water droplets, which has the potential to further increase the efficiency of systems that can harness jumping droplets for a wide range of energy and water applications.

  16. How far can Tarzan jump?

    Science.gov (United States)

    Shima, Hiroyuki

    2012-11-01

    The tree-based rope swing is a popular recreational facility, often installed in outdoor areas. Hanging from a rope, users drop from a high platform and then swing at great speed like ‘Tarzan’, finally jumping ahead to land on the ground. The question naturally arises, how far can Tarzan jump using the swing? In this paper, I present an introductory analysis of the mechanics of the Tarzan swing, a large pendulum-like swing with Tarzan himself attached as weight. This enables determination of how much further forward Tarzan can jump using a given swing apparatus. The discussion is based on elementary mechanics and is, therefore, expected to provide rich opportunities for investigations using analytic and numerical methods.

  17. How far can Tarzan jump?

    CERN Document Server

    Shima, Hiroyuki

    2012-01-01

    The tree-based rope swing is a popular recreation facility, often installed in outdoor areas, giving pleasure to thrill-seekers. In the setting, one drops down from a high platform, hanging from a rope, then swings at a great speed like "Tarzan", and finally jumps ahead to land on the ground. The question now arises: How far can Tarzan jump by the swing? In this article, I present an introductory analysis of the Tarzan swing mechanics, a big pendulum-like swing with Tarzan himself attached as weight. The analysis enables determination of how farther forward Tarzan can jump using a given swing apparatus. The discussion is based on elementary mechanics and, therefore, expected to provide rich opportunities for investigations using analytic and numerical methods.

  18. Alzheimer's Deaths Jump 55 Percent: CDC

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_165941.html Alzheimer's Deaths Jump 55 Percent: CDC More patients also ... News) -- As more baby boomers age, deaths from Alzheimer's disease have jumped 55 percent, and in a ...

  19. Inherent enumerability of strong jump-traceability

    CERN Document Server

    Diamondstone, David; Turetsky, Daniel

    2011-01-01

    We show that every strongly jump-traceable set obeys every benign cost function. Moreover, we show that every strongly jump-traceable set is computable from a computably enumerable strongly jump-traceable set. This allows us to generalise properties of c.e.\\ strongly jump-traceable sets to all such sets. For example, the strongly jump-traceable sets induce an ideal in the Turing degrees; the strongly jump-traceable sets are precisely those that are computable from all superlow Martin-L\\"{o}f random sets; the strongly jump-traceable sets are precisely those that are a base for $\\text{Demuth}_{\\text{BLR}}$-randomness; and strong jump-traceability is equivalent to strong superlowness.

  20. Model for polygonal hydraulic jumps

    DEFF Research Database (Denmark)

    Martens, Erik Andreas; Watanabe, Shinya; Bohr, Tomas

    2012-01-01

    ) near the free surface in the jump region. The model consists of mass conservation and radial force balance between hydrostatic pressure and viscous stresses on the roller surface. In addition, we consider the azimuthal force balance, primarily between pressure and viscosity, but also including...

  1. Jumping property of Lyapunov values

    Institute of Scientific and Technical Information of China (English)

    毛锐; 王铎

    1996-01-01

    A sufficient condition for fcth Lyapunov value to be zero for planar polynomial vector fields is given, which extends the result of "jumping property’ of Lyapunov values obtained by Wang Duo to more general cases. A concrete example that the origin cannot be weak focus of order 1, 2, 4, 5, 8 is presented.

  2. A jump forwards with mathematics and physics

    NARCIS (Netherlands)

    A. Heck; P. Uylings

    2011-01-01

    We jump on human body motions such as bouncing on a jumping stick, hopping, and making kangaroo jumps. Students can record the movements with a digital camera and use their video clips to investigate the motions with suitable video analysis and modelling software. We discuss some mathematical models

  3. Strawberry Shortcake and Other Jumping Rope Ideas.

    Science.gov (United States)

    Adams, Polly K.; Taylor, Michaell K.

    Information, guidelines, and activities for jumping rope are given. A short history of jumping rope explains how it evolved from a spring ritual for men to a play activity involving mostly young girls. Physical and cultural reasons are given as to why jumping rope has been more a sport for girls than for boys. Research studies are noted which show…

  4. Strawberry Shortcake and Other Jumping Rope Ideas.

    Science.gov (United States)

    Adams, Polly K.; Taylor, Michaell K.

    Information, guidelines, and activities for jumping rope are given. A short history of jumping rope explains how it evolved from a spring ritual for men to a play activity involving mostly young girls. Physical and cultural reasons are given as to why jumping rope has been more a sport for girls than for boys. Research studies are noted which show…

  5. Mesopause jumps at Antarctic latitudes

    Science.gov (United States)

    Lübken, Franz-Josef; Höffner, Josef; Becker, Erich; Latteck, Ralph; Murphy, Damian

    2016-04-01

    Recent high resolution temperature measurements by resonance lidar at Davis (69°S) occasionally showed a sudden mesopause altitude increase by ˜5 km and an associated mesopause temperature decrease by ˜10 K. We present further observations which are closely related to this 'mesopause jump', namely the increase of mean height of polar mesospheric summer echoes (PMSE) observed by a VHF radar, very strong westward winds in the upper mesosphere measured by an MF radar, and relatively large eastward winds in the stratosphere taken from reanalysis. We compare to similar observations in the Northern Hemisphere, namely at ALOMAR (69°N) where such mesopause jumps have never been observed. We present a detailed explanation of mesopause jumps. They occur only when stratospheric winds are moderately eastward and mesospheric winds are very large (westward). Under these conditions, gravity waves with comparatively large eastward phase Speeds can pass the stratosphere and propagate to the lower thermosphere because their vertical wavelengths in the mesosphere are rather large which implies reduced dynamical stability. When finally breaking in the lower thermosphere, these waves drive an enhanced residual circulation that causes a cold and high-altitude mesopause. The conditions for a mesopause jump occur only in the Southern Hemisphere (SH) and are associated with the late breakdown of the polar vortex. Mesopause jumps are primarily, but not only, observed prior and close to solstice. We also show that during the onset of PMSE in the SH, stratospheric zonal winds are still eastward (up to 30 m/s), and that the onset is not closely related to the Transition of the stratospheric circulation.

  6. Dynamic Aspects of Fairy Tales: Social and Emotional Competence through Fairy Tales.

    Science.gov (United States)

    Hohr, Hansjorg

    2000-01-01

    Explores how fairy tales address socio-emotional challenges children face during their socialization. Applies a structural theory of fairy tales to three literary versions of the Cinderella story. Suggests that the combination of simplicity of form and complexity of content makes the fairy tale a powerful tool for perception of and reflection on…

  7. The Public Right in Fairy Tales

    Directory of Open Access Journals (Sweden)

    Elena Massi

    2012-04-01

    Full Text Available I shall refer to the public right in fairy tales in light of the contribute of the folkloristic studies about authorship in fairy tales with a specific attention for those scholars who worked on an individual concept of authorship, such as Marke Azadovskij, Linda Dégh, Luz Rörich, R. Wehse and Key Stone. Taking into account legal implications raised by Helle Porsdam's anthology 'Copyright and other Fairy Tales', I will show how legal and scientific issues influenced that heterogeneous group of novels, short stories and children's books which today are known as fairy tales.

  8. Characteristics of Knock in Hydrogen-Oxygen-Argon SI Engine

    Energy Technology Data Exchange (ETDEWEB)

    Killingsworth, N; Rapp, V; Flowers, D; Aceves, S; Chen, J; Dibble, R

    2010-02-23

    A promising approach for improving the efficiency of internal combustion engines is to employ a working fluid with a high specific heat ratio such as the noble gas argon. Moreover, all harmful emissions are eliminated when the intake charge is composed of oxygen, nonreactive argon, and hydrogen fuel. Previous research demonstrated indicated thermal efficiencies greater than 45% at 5.5 compression ratio in engines operating with hydrogen, oxygen, and argon. However, knock limits spark advance and increasing the efficiency further. Conditions under which knock occurs in such engines differs from typical gasoline fueled engines. In-cylinder temperatures using hydrogen-oxygen-argon are higher due to the high specific heat ratio and pressures are lower because of the low compression ratio. Better understanding of knock under these conditions can lead to operating strategies that inhibit knock and allow operation closer to the knock limit. In this work we compare knock with a hydrogen, oxygen, and argon mixture to that of air-gasoline mixtures in a variable compression ratio cooperative fuels research (CFR) engine. The focus is on stability of knocking phenomena, as well as, amplitude and frequency of the resulting pressure waves.

  9. Jumps of the eta invariant

    CERN Document Server

    Farber, M S; Farber, Michael S.; Levine, Jerome P.

    1994-01-01

    We study the eta-invariant, defined by Atiyah-Patodi-Singer a real valued invariant of an oriented odd-dimensional Riemannian manifold equipped with a unitary representation of its fundamental group. When the representation varies analytically, the corresponding eta-invariant may have an integral jump, known also as the spectral flow. The main result of the paper establishes a formula for this spectral jump in terms of the signatures of some homological forms, defined naturally by the path of representations. These signatures may also be computed by means of a spectral sequence of Hermitian forms,defined by the deformation data. Our theorem on the spectral jump has a generalization to arbitrary analytic families of self-adjoint elliptic operators. As an application we consider the problem of homotopy invariance of the rho-invariant. We give an intrinsic homotopy theoretic definition of the rho-invariant, up to indeterminacy in the form of a locally constant function on the space of unitary representations. In...

  10. Happily Ever After? Teens and Fairy Tales.

    Science.gov (United States)

    Tuccillo, Diane P.

    2001-01-01

    Argues, from the author's experience and with supporting quotes from many teenagers, that modern retellings of classic fairy tales can be very popular with teenage readers. Discusses numerous such stories, and offers an extensive list of retold fairy tales, organized into: Cinderella stories, Beauty and the Beast stories, Sleeping Beauty stories,…

  11. "Turtle Island Tales." Cue Sheet for Students.

    Science.gov (United States)

    Carr, Gail

    This performance guide is designed for teachers to use with students before and after a shadow play performance of "Turtle Island Tales" by Hobey Ford and His Golden Rod Puppets. The guide, called a "Cuesheet," contains seven activity sheets for use in class, addressing: (1) The Tales (offering brief outlines of the three tales…

  12. A Tall Tale: Laura Amy Schlitz

    Science.gov (United States)

    Gallagher, Mary Grace

    2008-01-01

    In this article, American author, children's librarian, and storyteller Laura Amy Schlitz is profiled. Schlitz is the winner of this year's Newbery Medal for her tall tale about the Mongols called "Gulnara the Tartar Warrior." Like her award-winning book, "Good Masters! Sweet Ladies!" (Candlewick, 2007), the tale takes place in the Middle Ages.…

  13. Price jumps on European stock markets

    Directory of Open Access Journals (Sweden)

    Jan Hanousek

    2014-03-01

    Full Text Available We analyze the dynamics of price jumps and the impact of the European debt crisis using the high-frequency data reported by selected stock exchanges on the European continent during the period January 2008 to June 2012. We employ two methods to identify price jumps: Method 1 minimizes the probability of false jump detection (the Type-II Error-Optimal price jump indicator and Method 2 maximizes the probability of successful jump detection (the Type-I Error-Optimal price jump indicator. We show that individual stock markets exhibited differences in price jump intensity before and during the crisis. We also show that in general the variance of price jump intensity could not be distinguished as different in the pre-crisis period from that during the crisis. Our results indicate that, contrary to common belief, the intensity of price jumps does not uniformly increase during a period of financial distress. However, there do exist differences in price jump dynamics across stock markets and investors have to model emerging and mature markets differently to properly reflect their individual dynamics.

  14. [Review] Mary Toft's Rabbit Tale

    OpenAIRE

    Jones, Emrys

    2013-01-01

    Originally broadcast in April 2011 and aired again by BBC Radio 4 this November, Mary Toft’s Rabbit Tale is a radio drama retelling the story of its titular fraudster’s brief notoriety. With a high-profile cast – including singer Will Young as Toft’s husband and Rupert Graves as man-midwife, John Howard – the play explores a number of issues related to the alleged rabbit births of 1726 and their impact on public discourse of the time.

  15. A Village of Folk Tales

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    WUJIAGOU, a small and remote village in Hubei Province, is gaining fame for its Chinese folk tales. With only 878 villagers in 216 households, experts call it "a living fossil of the culture of Hubei Province." Sitting deep in the majestic Wudangshan Mountain, the shrine of Taoism and surrounded by breathtaking scenery, Wujiagou Village has a long history. Closed-off geographically, its villagers live scattered among the valleys. The village oozes local flavors, rich with traditional customs. Villagers gather spontaneously to sing folk songs

  16. Familiar Fairy Tale Picture Books Transformed into Teen Novels.

    Science.gov (United States)

    Chance, Rosemary

    2003-01-01

    Describes characteristics of fairy tales. Discusses use of fairy tales and novels for teens in the classroom. Presents annotations of 31 titles including both picture books and young adult novels grouped by nine popular tales. Concludes that through comparing picture books and teen novels, there is one last chance to introduce fairy tales to older…

  17. Δ-matroid and jump system

    Directory of Open Access Journals (Sweden)

    Santosh N. Kabadi

    2005-01-01

    Full Text Available The concept of Δ-matroid is a nontrivial, proper generalization of the concept of matroid and has been further generalized to the concept of jump system. In this paper, we show that jump systems are, in some sense, equivalent to Δ-matroids. Using this equivalence and the Δ-matroid theory, we give simple proofs and extensions of many of the results on jump systems.

  18. Time change, jumping measure and Feller measure

    OpenAIRE

    He, Ping

    2007-01-01

    In this paper, we shall investigate some potential theory for time change of Markov processes. Under weak duality, it is proved that the jumping measure and Feller measure are actually independent of time change, and the jumping measure of a time changed process induced by a PCAF supported on $V$ coincides with the sum of the Feller measure on $V$ and the trace of the original jumping measure on $V$.

  19. The aerodynamics of jumping rope

    Science.gov (United States)

    Aristoff, Jeffrey; Stone, Howard

    2011-03-01

    We present the results of a combined theoretical and experimental investigation of the motion of a rotating string that is held at both ends (i.e. a jump rope). In particular, we determine how the surrounding fluid affects the shape of the string at high Reynolds numbers: the string bends toward the axis of rotation, thereby reducing its total drag. We derive a pair of coupled non-linear differential equations that describe the shape, the numerical solution of which compares well with asymptotic approximations and experiments. Implications for successful skipping will be discussed.

  20. Dynamic jump intensities and risk premiums

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Ornthanalai, Chayawat; Jacobs, Kris

    2012-01-01

    We build a new class of discrete-time models that are relatively easy to estimate using returns and/or options. The distribution of returns is driven by two factors: dynamic volatility and dynamic jump intensity. Each factor has its own risk premium. The models significantly outperform standard...... models without jumps when estimated on S&P500 returns. We find very strong support for time-varying jump intensities. Compared to the risk premium on dynamic volatility, the risk premium on the dynamic jump intensity has a much larger impact on option prices. We confirm these findings using joint...... estimation on returns and large option samples....

  1. Laminar circular hydraulic jumps without separation

    Science.gov (United States)

    Dasgupta, Ratul; Tomar, Gaurav; Govindarajan, Rama

    2009-11-01

    The traditional inviscid criterion for the occurrence of a planar, standing hydraulic jump is to have the Froude number decrease downstream and go through a value of 1 at some location. Here, upstream propagating, small-amplitude, long, non-dispersive gravity waves are trapped, and non-linear steepening is said to result in a near-discontinuous height profile, but it is not clear how. Such a condition on the Froude number is shown in the present axisymmetric Navier-Stokes computations to hold for a circular jump as well. The relevance of non-linear steepening to a circular jump is therefore a question we wish to answer. In circular jumps, moreover, a region of recirculation is usually observed underneath the jump, underlining the importance of viscosity in this process. This led Tani (J. Phys. Soc. Japan, 1949) to hypothesise that boundary-layer separation was the cause of the circular jump. This hypothesis has been debated extensively and the possibility of circular jumps without separation hinted at. In our simulations, we are able to obtain circular hydraulic jumps without any flow separation. This, and the necessity or otherwise of viscosity in jump formation will be discussed.

  2. A Molecular Jump Mechanism of Water Reorientation

    National Research Council Canada - National Science Library

    Damien Laage; James T. Hynes

    2006-01-01

    .... This water reorientation mechanism involves large-amplitude angular jumps, rather than the commonly accepted sequence of small diffusive steps, and therefore calls for reinterpretation of many...

  3. Scientific Items in Cyprus Turkish Tales

    Directory of Open Access Journals (Sweden)

    Sevilay Atmaca

    2013-05-01

    Full Text Available Folk literature, which is a production of daily life experiences transferred from mouth to mouth, encompasses many types such as epic, legend, folk poetry, mania, laments, songs, riddles, tales, folk story, anecdote, proverbs, idioms, rhymes, and etc. These products, which represent the oral tradition of the people, transfer numerous information regarding the life experiences, beliefs, and values of their communities to the next generation. Tales are more attractive since they depict extraordinary events and because of these characteristics they are very didactic. These are some reasons why tales have a very significant place in Turkish folk literature. People have documented tales successfully transferring from a nomadic life to a settled one. This study attempts to determine the scientific elements in Cyprus Turkish Tales, as sample in the scope of the Turkish Tales, through content analysis. Researchers in this study will examine the themes in the selected tales such as “Earth and Cosmos”, “Physical Event”, “Matter and Change”, and “Living Organisms and Life”. They will also provide a code-list according to the themes found in the tales. Researchers will do a content analysis in relation to the themes and code-listing activities in “Cyprus Turkish Tales” collected by Mustafa Gökçeoğlu, a well-known Cyprus Turkish folk literature writer. It is seen from the research that living organism and life (f: 25 and matter and change (f: 24 themes have very abundant coded. It is followed with an orderly physical events theme (f: 13 and earth and cosmos theme (f: 6. As a result, it is seen that in samples which are taken from Turkish Cypriot Tales, scientific items are widely used. It is believed that the results of the study will give different perspectives to Turkish Language, literature, science-technology, and classroom teacher providing them with interdisciplinary and rich materials.

  4. Kinematics and Kinetics of Squats, Drop Jumps and Imitation Jumps of Ski Jumpers.

    Science.gov (United States)

    Pauli, Carole A; Keller, Melanie; Ammann, Fabian; Hübner, Klaus; Lindorfer, Julia; Taylor, William R; Lorenzetti, Silvio

    2016-03-01

    Squats, drop jumps, and imitation jumps are commonly used training exercises in ski jumping to enhance maximum force, explosive force, and sport-specific skills. The purpose of this study was to evaluate the kinetics and kinematics of training exercises in ski jumping and to find objective parameters in training exercises that most correlate with the competition performance of ski jumpers. To this end, barbell squats, drop jumps, and imitation jumps were measured in a laboratory environment for 10 elite ski jumpers. Force and motion data were captured, and the influence of maximum vertical force, force difference, vertical take-off velocity, knee moments, knee joint power, and a knee valgus/varus index was evaluated and correlated with their season jump performance. The results indicate that, especially for the imitation jumps, a good correlation exists between the vertical take-off velocity and the personal jump performance on the hill (R = 0.718). Importantly, however, the more the athletes tended toward a valgus knee alignment during the measured movements, the worse their performance (R = 0.729 imitation jumps; R = 0.685 squats). Although an evaluation of the athletes' lower limb alignment during competitive jumping on the hill is still required, these preliminary data suggest that performance training should additionally concentrate on improving knee alignment to increase ski jumping performance.

  5. Tales of physicists and mathematicians

    CERN Document Server

    Gindikin, Semyon Grigorevich

    1988-01-01

    This revised and greatly expanded second edition of the classic Russian text Tales of Mathematicians and Physicists contains a wealth of new information about the lives and accomplishments of more than a dozen scientists throughout history. Included are individuals from the late nineteenth century: Klein, Poincaré, Ramanujan, and Penrose, as well as renowned figures from earlier eras, such as Leibniz, Euler, Lagrange, and Laplace. A unique mixture of mathematics, physics, and history, this volume provides biographical glimpses of scientists and their contributions in the context of the social and political background of their times. The author examines many original sources, from the scientists’ research papers to their personal documents and letters to friends and family; furthermore, detailed mathematical arguments and diagrams are supplied to help explain some of the most significant discoveries in calculus, celestial mechanics, number theory, and modern relativity. What emerges are intriguing, multifac...

  6. Anthropology: The Long Lives of Fairy Tales.

    Science.gov (United States)

    Pagel, Mark

    2016-04-04

    Anthropologists, borrowing techniques from evolutionary biology, have demonstrated that some common fairy tales can be traced back 5,000 years, or more, long before the development of written traditions.

  7. Electroencephalographic recordings during parachute jump sessions.

    Science.gov (United States)

    Gauthier, P; Jouffray, L; Rodi, M; Gottesmann, C

    1980-04-01

    Electroencephalographic (EEG) recordings of experienced parachutists were done by means of telemetry before, during, and after jumps of up to 3500m. During free-fall and after stabilization, alpha rhythm was recorded from several alpha reactive subjects when they closed their eyes. No pathological EEG recordings were obtained during the different phases of the jump.

  8. Jump Detection in the Danish Stock Market

    DEFF Research Database (Denmark)

    Høg, Esben

    2002-01-01

    It is well known in financial economics that stock market return data are often modelled by a diffusion process with some regular drift function. Occasionally, however, sudden changes or jumps occur in the return data. Wavelet scaling methods are used to detect jumps and cusps in stock market...

  9. Rope Jumping: A Preliminary Developmental Study.

    Science.gov (United States)

    Wickstrom, Ralph L.

    The basic movement pattern used in skilled individual rope jumping performance was determined and used as a model against which to evaluate the rope jumping form used by children at various levels of skills development. The techniques of adults and nursery school children were filmed and analyzed. The specific causes of unsuccessful attempts were…

  10. Separation and pattern formation in hydraulic jumps

    DEFF Research Database (Denmark)

    Bohr, Tomas; Ellegaard, C.; Hansen, A. Espe;

    1998-01-01

    We present theory and experiments on the circular hydraulic jump in the stationary regime. The theory can handle the situation in which the fluid flows over an edge far away from the jump. In the experiments the external height is controlled, and a series of transitions in the flow structure appe...

  11. Internal hydraulic jumps with large upstream shear

    Science.gov (United States)

    Ogden, Kelly; Helfrich, Karl

    2015-11-01

    Internal hydraulic jumps in approximately two-layered flows with large upstream shear are investigated using numerical simulations. The simulations allow continuous density and velocity profiles, and a jump is forced to develop by downstream topography, similar to the experiments conducted by Wilkinson and Wood (1971). High shear jumps are found to exhibit significantly more entrainment than low shear jumps. Furthermore, the downstream structure of the flow has an important effect on the jump properties. Jumps with a slow upper (inactive) layer exhibit a velocity minimum downstream of the jump, resulting in a sub-critical downstream state, while flows with the same upstream vertical shear and a larger barotropic velocity remain super-critical downstream of the jump. A two-layer theory is modified to account for the vertical structure of the downstream density and velocity profiles and entrainment is allowed through a modification of the approach of Holland et al. (2002). The resulting theory can be matched reasonably well with the numerical simulations. However, the results are very sensitive to how the downstream vertical profiles of velocity and density are incorporated into the layered model, highlighting the difficulty of the two layer approximation when the shear is large.

  12. Strong jump traceability and Demuth randomness

    CERN Document Server

    Greenberg, Noam

    2011-01-01

    We solve the covering problem for Demuth randomness, showing that a computably enumerable set is computable from a Demuth random set if and only if it is strongly jump-traceable. We show that on the other hand, the class of sets which form a base for Demuth randomness is a proper subclass of the class of strongly jump-traceable sets.

  13. The Development of TALE Nucleases for Biotechnology

    OpenAIRE

    Ousterout, David G.; Gersbach, Charles A

    2016-01-01

    The development of a facile genome engineering technology based on transcription activator-like effector nucleases (TALENs) has led to significant advances in diverse areas of science and medicine. In this review, we provide a broad overview of the development of TALENs and the use of this technology in basic science, biotechnology, and biomedical applications. This includes the discovery of DNA recognition by TALEs, engineering new TALE proteins to diverse targets, general advances in nuclea...

  14. Tegn kan også Tale

    DEFF Research Database (Denmark)

    Fischer, Jutta; Niebe, Susanne; Bisgaard, Hanne

    "Tegn kan også Tale" er et begyndermateriale til undervisning af syns- og hørehæmmede døvblindblevne i taktil tegnstøttet kommunikation - en ny taktil kommunikationsform, som bygger på det danske sprog og bruger tegn og andre elementer fra døves tegnsprog. Tegn kan også Tale´ henvender sig primært...

  15. Stochastic stability properties of jump linear systems

    Science.gov (United States)

    Feng, Xiangbo; Loparo, Kenneth A.; Ji, Yuandong; Chizeck, Howard J.

    1992-01-01

    Jump linear systems are defined as a family of linear systems with randomly jumping parameters (usually governed by a Markov jump process) and are used to model systems subject to failures or changes in structure. The authors study stochastic stability properties in jump linear systems and the relationship among various moment and sample path stability properties. It is shown that all second moment stability properties are equivalent and are sufficient for almost sure sample path stability, and a testable necessary and sufficient condition for second moment stability is derived. The Lyapunov exponent method for the study of almost sure sample stability is discussed, and a theorem which characterizes the Lyapunov exponents of jump linear systems is presented.

  16. A review on the basketball jump shot.

    Science.gov (United States)

    Okazaki, Victor H A; Rodacki, André L F; Satern, Miriam N

    2015-06-01

    The ability to shoot an effective jump shot in the sport of basketball is critical to a player's success. In an attempt to better understand the aspects related to expert performance, researchers have investigated successful free throws and jump shots of various basketball players and identified movement variables that contribute to their success. The purpose of this study was to complete a systematic review of the scientific literature on the basketball free throw and jump shot for the purpose of revealing the critical components of shooting that coaches, teachers, and players should focus on when teaching, learning, practising, and performing a jump shot. The results of this review are presented in three sections: (a) variables that affect ball trajectory, (b) phases of the jump shot, and

  17. Usefulness of the jump-and-reach test in assessment of vertical jump performance.

    Science.gov (United States)

    Menzel, Hans-Joachim; Chagas, Mauro H; Szmuchrowski, Leszek A; Araujo, Silvia R; Campos, Carlos E; Giannetti, Marcus R

    2010-02-01

    The objective was to estimate the reliability and criterion-related validity of the Jump-and-Reach Test for the assessment of squat, countermovement, and drop jump performance of 32 male Brazilian professional volleyball players. Performance of squat, countermovement, and drop jumps with different dropping heights was assessed on the Jump-and-Reach Test and the measurement of flight time, then compared across different jump trials. The very high reliability coefficients of both assessment methods and the lower correlation coefficients between scores on the assessments indicate a very high consistency of each method but only moderate covariation, which means that they measure partly different items. As a consequence, the Jump-and-Reach Test has good ecological validity in situations when reaching height during the flight phase is critical for performance (e.g., basketball and volleyball) but only limited accuracy for the assessment of vertical impulse production with different jump techniques and conditions.

  18. Jumping from the Brooklyn Bridge.

    Science.gov (United States)

    Kurtz, R J; Pizzi, W F; Richman, H; Tiefenbrun, J

    1987-07-01

    In an attempt to identify factors contributing to survival of free fall and impact, we evaluated the records of four patients who survived a jump from the Brooklyn Bridge into the East River in New York Harbor between 1977 and 1985. All four patients were male and ranged in age from 22 to 67 years. They had free falls of between 41.0 and 48.8 meters. All of the patients were brought to the hospital within 24 minutes of entering the water. Three of the four had emergency surgical treatment and the fourth patient had only minor injuries. All four patients survived the suicide attempts. The length of the hospital stay ranged from two to 26 days.

  19. Jumping without using legs: the jump of the click-beetles (Elateridae is morphologically constrained.

    Directory of Open Access Journals (Sweden)

    Gal Ribak

    Full Text Available To return to their feet, inverted click-beetles (Elateridae jump without using their legs. When a beetle is resting on its dorsal side, a hinge mechanism is locked to store elastic energy in the body and releases it abruptly to launch the beetle into the air. While the functional morphology of the jumping mechanism is well known, the level of control that the beetle has over this jumping technique and the mechanical constraints governing the jumps are not entirely clear. Here we show that while body rotations in air are highly variable, the jumps are morphologically constrained to a constant "takeoff" angle (79.9°±1.56°, n = 9 beetles that directs 98% of the jumping force vertically against gravity. A physical-mathematical model of the jumping action, combined with measurements from live beetle, imply that the beetle may control the speed at takeoff but not the jumping angle. In addition, the model shows that very subtle changes in the exact point of contact with the ground can explain the vigorous rotations of the body seen while the beetle is airborne. These findings suggest that the evolution of this unique non-legged jumping mechanism resulted in a jumping technique that is capable of launching the body high into the air but it is too constrained and unstable to allow control of body orientation at landing.

  20. Realized Jump Risk and Equity Return in China

    Directory of Open Access Journals (Sweden)

    Guojin Chen

    2014-01-01

    Full Text Available We utilize the realized jump components to explore a new jump (including nonsystematic jump and systematic jump risk factor model. After estimating daily realized jumps from high-frequency transaction data of the Chinese A-share stocks, we calculate monthly jump size, monthly jump standard deviation, and monthly jump arrival rate and then use those monthly jump factors to explain the return of the following month. Our empirical results show that the jump tail risk can explain the equity return. For the large capital-size stocks, large cap stock portfolios, and index, one-month lagged jump risk factor significantly explains the asset return variation. Our results remain the same even when we add the size and value factors in the robustness tests.

  1. Bubble visualization in a simulated hydraulic jump

    CERN Document Server

    Witt, Adam; Shen, Lian

    2013-01-01

    This is a fluid dynamics video of two- and three-dimensional computational fluid dynamics simulations carried out at St. Anthony Falls Laboratory. A transient hydraulic jump is simulated using OpenFOAM, an open source numerical solver. A Volume of Fluid numerical method is employed with a realizable k-epsilon turbulence model. The goal of this research is to model the void fraction and bubble size in a transient hydraulic jump. This fluid dynamics video depicts the air entrainment characteristics and bubble behavior within a hydraulic jump of Froude number 4.82.

  2. Knock characteristics of dual-fuel combustion in diesel engines using natural gas as primary fuel

    Indian Academy of Sciences (India)

    O M I Nwafor

    2002-06-01

    This paper investigates the combustion knock characteristics of diesel engines running on natural gas using pilot injection as means of initiating combustion. The diesel engines knock under normal operating conditions but the knock referred to in this paper is an objectionable one. In the dual-fuel combustion process we have the ignition stage followed by the combustion stage. There are three types of knock: diesel knock, spark knock and knock due to secondary ignition delay of the primary fuel (erratic knock). Several factors have been noted to feature in defining knock characteristics of dual-fuel engines that include ignition delay, pilot quantity, engine load and speed, turbulence and gas flow rate.

  3. A Fairy-Tale Landscape

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation Fun, fairy-tale nicknames have been assigned to features in this animated view of the workspace reachable by the robotic arm of NASA's Phoenix Mars Lander. For example, 'Sleepy Hollow' denotes a trench and 'Headless' designates a rock. A 'National Park,' marked by purple text and a purple arrow, has been set aside for protection until scientists and engineers have tested the operation of the robotic scoop. First touches with the scoop will be to the left of the 'National Park' line. Scientists use such informal names for easy identification of features of interest during the mission. In this view, rocks are circled in yellow, other areas of interest in green. The images were taken by the lander's 7-foot mast camera, called the Surface Stereo Imager. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  4. Physics of the TALE Experiment

    Science.gov (United States)

    Thomson, G. B.

    The Telescope Array Low Energy Extension (TALE) Experiment consists of three detectors which will extend the sensitivity in energy of the Telescope Array (TA) experiment by two orders of magnitude, from 18.5

  5. The Category of Time in Fairy Tales: Searching for Folk Calendar Time in the Estonian Fairy Tale Corpus

    Directory of Open Access Journals (Sweden)

    Mairi Kaasik

    2008-12-01

    Full Text Available The article examines how folk calendar holidays are represented in Estonian fairy tales. It introduces some views presented in folklore studies about the concept of time in fairy tales and finds parallels with them in the Estonian context. The analysis relies on the digital corpus of Estonian fairy tales (5400 variants, created from the texts found in the Estonian Folklore Archives by the Fairy Tale Project of the Department of Estonian and Comparative Folklore, University of Tartu. Folk calendar holidays occur in Estonian fairy tales relatively seldom; most often these are holidays that occupy a significant place in the Estonian folk calendar (Christmas, St. John’s Day, Easter, St. George’s Day. Calendar holidays are notably mentioned more often in tale types which remain on the borderline between the fairy tale and the legend or the fairy tale and the religious tale. In Estonian fairy tales, calendar holidays are used on three levels of meaning: (1 the holiday is organically associated with the tale type; it has an essential role in the plot of the tale; (2 to a certain extent, the holiday could be replaced by another holiday having an analogous meaning; (3 the holiday forms an unimportant or occasional addition to the tale.

  6. "A Peculiar Understanding": Re-creating the Literary Fairy Tale.

    Science.gov (United States)

    Greene, Ellin

    1983-01-01

    Recommends literary fairy tales, or art fairy tales, as a rich source of material for the accomplished storyteller or for the beginner who has an affinity for stories written by literary stylists. (AEA)

  7. Knock Prediction Using a Simple Model for Ignition Delay

    KAUST Repository

    Kalghatgi, Gautam

    2016-04-05

    An earlier paper has shown the ability to predict the phasing of knock onset in a gasoline PFI engine using a simple ignition delay equation for an appropriate surrogate fuel made up of toluene and PRF (TPRF). The applicability of this approach is confirmed in this paper in a different engine using five different fuels of differing RON, sensitivity, and composition - including ethanol blends. An Arrhenius type equation with a pressure correction for ignition delay can be found from interpolation of previously published data for any gasoline if its RON and sensitivity are known. Then, if the pressure and temperature in the unburned gas can be estimated or measured, the Livengood-Wu integral can be estimated as a function of crank angle to predict the occurrence of knock. Experiments in a single cylinder DISI engine over a wide operating range confirm that this simple approach can predict knock very accurately. The data presented should enable engineers to study knock or other auto-ignition phenomena e.g. in premixed compression ignition (PCI) engines without explicit chemical kinetic calculations. © Copyright 2016 SAE International.

  8. A Scholar Who Knocks at the Door to Friendship

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Senegalese scholar Adama Gaye came from far away Africa to visit China in March when there was still a chill in the early spring air. He is not an ordinary scholar, but an African friend who has come to knock at the door to friendship.The government of Senegal established diplomatic relations

  9. The Computational Complexity of the Parallel Knock-Out Problem

    NARCIS (Netherlands)

    Broersma, H.J.; Johnson, M.; Paulusma, D.; Stewart, I.A.; Correa, J.R.; Hevia, A.; Kiwi, M.

    2006-01-01

    We consider computational complexity questions related to parallel knock-out schemes for graphs. In such schemes, in each round, each remaining vertex of a given graph eliminates exactly one of its neighbours. We show that the problem of whether, for a given graph, such a scheme can be found that el

  10. Robust, synergistic regulation of human gene expression using TALE activators.

    Science.gov (United States)

    Maeder, Morgan L; Linder, Samantha J; Reyon, Deepak; Angstman, James F; Fu, Yanfang; Sander, Jeffry D; Joung, J Keith

    2013-03-01

    Artificial activators designed using transcription activator-like effector (TALE) technology have broad utility, but previous studies suggest that these monomeric proteins often exhibit low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy, and guide design of monomeric TALE-based fusion proteins.

  11. The Crown Bite Jumping Herbst.

    Science.gov (United States)

    Owen, Reuel

    2003-01-01

    The Crown Bite Jumping Herbst Appliance is evaluated and combined with Straight Wire Arch Fixed Orthodontics in treatment of Class II, Division I malocclusions. This article will evaluate a combined orthodontic approach of "straightening teeth" and an orthognathic approach of "moving jaws or making skeletal changes." Orthodontic treatment cannot be accomplished well without establishing a healthy temporomandibular joint. This is defined by Keller as a joint that is "noiseless, painless and has a normal range of motion without deviation and deflection." It is not prudent to separate orthodontic treatment as its own entity without being aware of the changes in the temporomandibular joint before, during and after treatment. In other words, "If you're doing orthodontics you're doing TMJ treatment." One should treat toward a healthy, beautiful face asking, "Will proposed treatment achieve this goal?" Treatment should be able to be carried out in an efficient manner, minimizing treatment time, be comfortable and affordable for the patient, and profitable for the dentist. The finished treatment should meet Andrews' Six Keys of Occlusion, or Loudon's Twelve Commandments. Above all, do no harm to the patient. We think that a specific treatment plan can embrace these tenets. The focus will be to show Class II treatment using a modified Herbst Appliance and fixed straight wire orthodontics.

  12. Volatility jumps and their economic determinants

    DEFF Research Database (Denmark)

    Caporin, Massimiliano; Rossi, Eduardo; Santucci de Magistris, Paolo

    that there is a positive probability of jumps in volatility. A common factor in the volatility jumps is shown to be related to a set of financial covariates (such as variance risk premium, S&P500 volume, credit-default swap, and federal fund rates). The credit-default swap on US banks and variance risk premium have...... predictive power on expected jump moves, thus confirming the common interpretation that sudden and large increases in equity volatility can be anticipated by credit deterioration of the US bank sector as well as changes in the market expectations of future risks. Finally, the model is extended to incorporate...... the credit-default swap and the variance risk premium in the dynamics of the jump size and intensity....

  13. Jump Horse Safety: Reconciling Public Debate and Australian Thoroughbred Jump Racing Data, 2012-2014.

    Science.gov (United States)

    Ruse, Karen; Davison, Aidan; Bridle, Kerry

    2015-10-22

    Thoroughbred jump racing sits in the spotlight of contemporary welfare and ethical debates about horse racing. In Australia, jump racing comprises hurdle and steeplechase races and has ceased in all but two states, Victoria and South Australia. This paper documents the size, geography, composition, and dynamics of Australian jump racing for the 2012, 2013, and 2014 seasons with a focus on debate about risks to horses. We found that the majority of Australian jump racing is regional, based in Victoria, and involves a small group of experienced trainers and jockeys. Australian jump horses are on average 6.4 years of age. The jump career of the majority of horses involves participating in three or less hurdle races and over one season. Almost one quarter of Australian jump horses race only once. There were ten horse fatalities in races over the study period, with an overall fatality rate of 5.1 fatalities per 1000 horses starting in a jump race (0.51%). There was significant disparity between the fatality rate for hurdles, 0.75 fatalities per 1000 starts (0.075%) and steeplechases, 14 fatalities per 1000 starts (1.4%). Safety initiatives introduced by regulators in 2010 appear to have significantly decreased risks to horses in hurdles but have had little or no effect in steeplechases. Our discussion considers these Animals 2015, 5 1073 data in light of public controversy, political debate, and industry regulation related to jump horse safety.

  14. Jump Horse Safety: Reconciling Public Debate and Australian Thoroughbred Jump Racing Data, 2012–2014

    Directory of Open Access Journals (Sweden)

    Karen Ruse

    2015-10-01

    Full Text Available Thoroughbred jump racing sits in the spotlight of contemporary welfare and ethical debates about horse racing. In Australia, jump racing comprises hurdle and steeplechase races and has ceased in all but two states, Victoria and South Australia. This paper documents the size, geography, composition, and dynamics of Australian jump racing for the 2012, 2013, and 2014 seasons with a focus on debate about risks to horses. We found that the majority of Australian jump racing is regional, based in Victoria, and involves a small group of experienced trainers and jockeys. Australian jump horses are on average 6.4 years of age. The jump career of the majority of horses involves participating in three or less hurdle races and over one season. Almost one quarter of Australian jump horses race only once. There were ten horse fatalities in races over the study period, with an overall fatality rate of 5.1 fatalities per 1000 horses starting in a jump race (0.51%. There was significant disparity between the fatality rate for hurdles, 0.75 fatalities per 1000 starts (0.075% and steeplechases, 14 fatalities per 1000 starts (1.4%. Safety initiatives introduced by regulators in 2010 appear to have significantly decreased risks to horses in hurdles but have had little or no effect in steeplechases. Our discussion considers these Animals 2015, 5 1073 data in light of public controversy, political debate, and industry regulation related to jump horse safety.

  15. Through Fairy-Tales to Math in the Lessons

    Science.gov (United States)

    Andersone, Rudite

    2009-01-01

    Every person in his lifetime has many times experienced the miraculous impact of the fairy-tale on his imagination, mind and feelings. But we seldom reflect upon the content not only in the ethical aspect of fairy-tales but also as a source of different kinds of knowledge, among them the knowledge of mathematics. The use of fairy-tales in lessons…

  16. Using Fairy Tales To Generate High Interest in Short Fiction.

    Science.gov (United States)

    McKenna, Barbara J.

    2001-01-01

    Discusses how fairy tales provide the vehicle by which students become genuinely engaged in reading and writing short fiction. Outlines a three-step process moving students from familiar stories, to variations on traditional tales, finally to new stories. Details how writing, revising, illustrating, and binding a fairy tale engages students. (PM)

  17. Portfolio Selection with Jumps under Regime Switching

    Directory of Open Access Journals (Sweden)

    Lin Zhao

    2010-01-01

    Full Text Available We investigate a continuous-time version of the mean-variance portfolio selection model with jumps under regime switching. The portfolio selection is proposed and analyzed for a market consisting of one bank account and multiple stocks. The random regime switching is assumed to be independent of the underlying Brownian motion and jump processes. A Markov chain modulated diffusion formulation is employed to model the problem.

  18. Preschool-aged children's jumps: imitation performances.

    Science.gov (United States)

    Labiadh, Lazhar; Ramanantsoa, Marie-Martine; Golomer, Eveline

    2010-04-01

    Imitative behavior underlaid by perception and action links during children's development in complex locomotor skills has been the object of relatively few studies. In order to explore children's motor coordination modes, 130 children divided into five age groups from 3.5 to 7.5 years were instructed to imitate jumping tasks in spontaneous motor situation and in various imitative contexts by an adult providing verbal orders and gestural demonstrations. Their conformity to the model, stability and variability scores were coded from a video analysis when they performed jumps with obstacles. To evaluate their postural-motor control level, the durations of the preparatory phase and jumping flights were also timed. Results showed that all age groups generated the demonstrator's goal but not necessarily the same coordination modes of jumping. In imitation with temporal proximity, the model helped the youngest age groups to adopt his coordination modes and stabilized only the oldest age groups' performances starting from 5.5 years old, without effect on learning imitation. Differences between the youngest and oldest children in the jump duration suggested that the reproduction of a complex motor activity such as jumping with a one foot take-off would require resolution and adjustment of main postural stability.

  19. TALE nucleases and next generation GM crops.

    Science.gov (United States)

    Mahfouz, Magdy M; Li, Lixin

    2011-01-01

    Site-specific and adaptable DNA binding domains are essential modules to develop genome engineering technologies for crop improvement. Transcription activator-like effectors (TALEs) proteins are used to provide a highly specific and adaptable DNA binding modules. TALE chimeric nucleases (TALENs) were used to generate site-specific double strand breaks (DSBs) in vitro and in yeast, Caenorhabditis elegans, mammalian and plant cells. The genomic DSBs can be generated at predefined and user-selected loci and repaired by either the non-homologous end joining (NHEJ) or homology dependent repair (HDR). Thus, TALENs can be used to achieve site-specific gene addition, stacking, deletion or inactivation. TALE-based genome engineering tools should be powerful to develop new agricultural biotechnology approaches for crop improvement. Here, we discuss the recent research and the potential applications of TALENs to accelerate the generation of genomic variants through targeted mutagenesis and to produce a non-transgenic GM crops with the desired phenotype.

  20. TALE nucleases and next generation GM crops.

    KAUST Repository

    Mahfouz, Magdy M.

    2011-04-01

    Site-specific and adaptable DNA binding domains are essential modules to develop genome engineering technologies for crop improvement. Transcription activator-like effectors (TALEs) proteins are used to provide a highly specific and adaptable DNA binding modules. TALE chimeric nucleases (TALENs) were used to generate site-specific double strand breaks (DSBs) in vitro and in yeast, Caenorhabditis elegans, mammalian and plant cells. The genomic DSBs can be generated at predefined and user-selected loci and repaired by either the non-homologous end joining (NHEJ) or homology dependent repair (HDR). Thus, TALENs can be used to achieve site-specific gene addition, stacking, deletion or inactivation. TALE-based genome engineering tools should be powerful to develop new agricultural biotechnology approaches for crop improvement. Here, we discuss the recent research and the potential applications of TALENs to accelerate the generation of genomic variants through targeted mutagenesis and to produce a non-transgenic GM crops with the desired phenotype.

  1. Performance analysis of jump-gliding locomotion for miniature robotics.

    Science.gov (United States)

    Vidyasagar, A; Zufferey, Jean-Christohphe; Floreano, Dario; Kovač, M

    2015-03-26

    Recent work suggests that jumping locomotion in combination with a gliding phase can be used as an effective mobility principle in robotics. Compared to pure jumping without a gliding phase, the potential benefits of hybrid jump-gliding locomotion includes the ability to extend the distance travelled and reduce the potentially damaging impact forces upon landing. This publication evaluates the performance of jump-gliding locomotion and provides models for the analysis of the relevant dynamics of flight. It also defines a jump-gliding envelope that encompasses the range that can be achieved with jump-gliding robots and that can be used to evaluate the performance and improvement potential of jump-gliding robots. We present first a planar dynamic model and then a simplified closed form model, which allow for quantification of the distance travelled and the impact energy on landing. In order to validate the prediction of these models, we validate the model with experiments using a novel jump-gliding robot, named the 'EPFL jump-glider'. It has a mass of 16.5 g and is able to perform jumps from elevated positions, perform steered gliding flight, land safely and traverse on the ground by repetitive jumping. The experiments indicate that the developed jump-gliding model fits very well with the measured flight data using the EPFL jump-glider, confirming the benefits of jump-gliding locomotion to mobile robotics. The jump-glide envelope considerations indicate that the EPFL jump-glider, when traversing from a 2 m height, reaches 74.3% of optimal jump-gliding distance compared to pure jumping without a gliding phase which only reaches 33.4% of the optimal jump-gliding distance. Methods of further improving flight performance based on the models and inspiration from biological systems are presented providing mechanical design pathways to future jump-gliding robot designs.

  2. Himalayan Folklore and the Fairy Tale Genre

    Directory of Open Access Journals (Sweden)

    Jane Orton

    2016-07-01

    Full Text Available Based on fieldwork by the author conducted in Tibetan cultural areas of the Indian Himalayas, this paper explores Himalayan understandings of what defines a fairy tale, in contrast to the Western understanding. In parts of the Himalayas, a distinction is made between “lakshung” (fairy tales and “kyakshung”, which are shorter stories, the kind one might tell over tea. In light of the proposals to record and disseminate many of these stories using new media, this paper seeks to examine these genre definitions and investigates the various contexts in which these stories are told.

  3. Jump Horse Safety: Reconciling Public Debate and Australian Thoroughbred Jump Racing Data, 2012–2014

    Science.gov (United States)

    Ruse, Karen; Davison, Aidan; Bridle, Kerry

    2015-01-01

    Simple Summary This paper documents the dynamics of Australian thoroughbred jump racing in the 2012, 2013, and 2014 seasons with the aim of informing debate about risks to horses and the future of this activity. We conclude that the safety of Australian jump racing has improved in recent years but that steeplechases are considerably riskier for horses than hurdle races. Abstract Thoroughbred jump racing sits in the spotlight of contemporary welfare and ethical debates about horse racing. In Australia, jump racing comprises hurdle and steeplechase races and has ceased in all but two states, Victoria and South Australia. This paper documents the size, geography, composition, and dynamics of Australian jump racing for the 2012, 2013, and 2014 seasons with a focus on debate about risks to horses. We found that the majority of Australian jump racing is regional, based in Victoria, and involves a small group of experienced trainers and jockeys. Australian jump horses are on average 6.4 years of age. The jump career of the majority of horses involves participating in three or less hurdle races and over one season. Almost one quarter of Australian jump horses race only once. There were ten horse fatalities in races over the study period, with an overall fatality rate of 5.1 fatalities per 1000 horses starting in a jump race (0.51%). There was significant disparity between the fatality rate for hurdles, 0.75 fatalities per 1000 starts (0.075%) and steeplechases, 14 fatalities per 1000 starts (1.4%). Safety initiatives introduced by regulators in 2010 appear to have significantly decreased risks to horses in hurdles but have had little or no effect in steeplechases. Our discussion considers these data in light of public controversy, political debate, and industry regulation related to jump horse safety. PMID:26506396

  4. Jumping to conclusions in schizophrenia

    Directory of Open Access Journals (Sweden)

    Evans SL

    2015-07-01

    Full Text Available Simon L Evans,1 Bruno B Averbeck,2 Nicholas Furl31School of Psychology, University of Sussex, Brighton, East Sussex, UK; 2Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA; 3Department of Psychology, Royal Holloway, University of London, Egham, Surrey, UKAbstract: Schizophrenia is a mental disorder associated with a variety of symptoms, including hallucinations, delusions, social withdrawal, and cognitive dysfunction. Impairments on decision-making tasks are routinely reported: evidence points to a particular deficit in learning from and revising behavior following feedback. In addition, patients tend to make hasty decisions when probabilistic judgments are required. This is known as “jumping to conclusions” (JTC and has typically been demonstrated by presenting participants with colored beads drawn from one of two “urns” until they claim to be sure which urn the beads are being drawn from (the proportions of colors vary in each urn. Patients tend to make early decisions on this task, and there is evidence to suggest that a hasty decision-making style might be linked to delusion formation and thus be of clinical relevance. Various accounts have been proposed regarding what underlies this behavior. In this review, we briefly introduce the disorder and the decision-making deficits associated with it. We then explore the evidence for each account of JTC in the context of a wider decision-making deficit and then go on to summarize work exploring JTC in healthy controls using pharmacological manipulations and functional imaging. Finally, we assess whether JTC might have a role in therapy.Keywords: ketamine, decision making, delusions, fMRI, urn task

  5. Fairy tales as a trance experience: possible therapeutic uses.

    Science.gov (United States)

    Stevens-Guille, M E; Boersma, F J

    1992-04-01

    The psychological literature contains little documentation of the therapeutic use of fairy tales. We suggest that fairy tales are uniquely suitable for hypnotherapy and for helping clients reframe existential issues. We propose that the structure of fairy tales allows the meaning of the story to be applied personally and that they also stimulate unconscious search. We examine the way in which hypnosis is achieved when fairy tales are read to children, as well as possible therapeutic uses of this learning set in therapy with both children and adults. We conclude by suggesting that fairy tales need to be given serious consideration as an alternative therapeutic trance procedure.

  6. Knock Detection in a Two-Stroke Engine to be Used in the Engine Management System

    OpenAIRE

    Höglund, Filip

    2014-01-01

    Engine knock has long been a well recognized phenomenon in the automotive industry. Detecting engine knock opens up the possibility for an indirect feedback of the engine's internal combustion without installing a pressure transducer inside the cylinder. Knock detection has mainly been used for spark advance control, making it possible to control the engine close to its knock limit in search for the optimal ignition timing. This application has to a lesser extent been applied to lightweight t...

  7. A biomechanical comparison of the vertical jump, power clean, and jump squat.

    Science.gov (United States)

    MacKenzie, Sasho James; Lavers, Robert J; Wallace, Brendan B

    2014-01-01

    The purpose of this study was to compare the kinetics, kinematics, and muscle activation patterns of the countermovement jump, the power clean, and the jump squat with the expectation of gaining a better understanding of the mechanism of transfer from the power clean to the vertical jump. Ground reaction forces, electromyography, and joint angle data were collected from 20 trained participants while they performed the three movements. Relative to the power clean, the kinematics of the jump squat were more similar to those of the countermovement jump. The order in which the ankle, knee, and hip began extending, as well as the subsequent pattern of extension, was different between the power clean and countermovement jump. The electromyography data demonstrated significant differences in the relative timing of peak activations in all muscles, the maximum activation of the rectus femoris and biceps femoris, and in the activation/deactivation patterns of the vastus medialis and rectus femoris. The greatest rate of force development during the upward phase of these exercises was generated during the power clean (17,254 [Formula: see text]), which was significantly greater than both the countermovement jump (3836 [Formula: see text]) and jump squat (3517 [Formula: see text]) conditions (P < .001, [Formula: see text]).

  8. I'll knock you when I'm ready

    DEFF Research Database (Denmark)

    Rasmussen, Majken Kirkegaard; Krogh, Peter; Lehoux, Natalie

    2012-01-01

    Following the research field of Computer Mediated Communication (CMC), we explore and expand upon the notion of media richness. We consider the term outside its ordinary domain of conventional communication mediums, such as email, phone or video calls. We focus on minimal communication......, and the qualities of suggestive interactions that mediate communication. We introduce Knock-Knock as a novel, shape-changing communication medium, and use it as a rhetorical tool to reflect upon the notion of media richness. In doing so, we highlight the value of meaning and language creation that suggestive...... communication mediums make possible. Finally, we propose three directions for the future evaluation of the richness experienced in communication, mediated by suggestive communication artefacts....

  9. The effect of wind on jumping distance in ski jumping--fairness assessed.

    Science.gov (United States)

    Virmavirta, Mikko; Kivekäs, Juha

    2012-09-01

    The special wind compensation system recently adopted by Fédération Internationale de Ski (FIS; International Ski Federation) to consider the effects of changing wind conditions has caused some controversy. Here, the effect of wind on jumping distance in ski jumping was studied by means of computer simulation and compared with the wind compensation factors used by FIS during the World Cup season 2009/2010. The results showed clearly that the effect of increasing head/tail wind on jumping distance is not linear: +17.4 m/-29.1 m, respectively, for a wind speed of 3 m/s. The linear formula used in the trial period of the wind compensation system was found to be appropriate only for a limited range of jumping distances as the gradient of the landing slope slows down the rate of distance change in long jumps.

  10. "Clockwork": Philip Pullman's Posthuman Fairy Tale

    Science.gov (United States)

    Gooding, Richard

    2011-01-01

    This article examines the connections between posthumanism and narrative form in Philip Pullman's "Clockwork." Beginning with an account of Pullman's materialism, it argues that the novel represents consciousness and agency as emergent properties of matter, a position that manifests itself first in the tale's figurative language and later in the…

  11. Fairy Tale Retellings between Art and Pedagogy

    Science.gov (United States)

    Joosen, Vanessa

    2005-01-01

    In this article, it is shown how authors of fairy tale retellings have incorporated ideas of feminist literary criticism into a fictional form. As such, these retellings display the tension between the pedagogic and aesthetic aspects of all children's literature. Jane Yolen's "Sleeping Ugly" is chosen as a case study: although it can be argued…

  12. "Clockwork": Philip Pullman's Posthuman Fairy Tale

    Science.gov (United States)

    Gooding, Richard

    2011-01-01

    This article examines the connections between posthumanism and narrative form in Philip Pullman's "Clockwork." Beginning with an account of Pullman's materialism, it argues that the novel represents consciousness and agency as emergent properties of matter, a position that manifests itself first in the tale's figurative language and later in the…

  13. Semi-étale groupoids and applications

    DEFF Research Database (Denmark)

    Thomsen, Klaus

    2010-01-01

    We associate a C * -algebra to a locally compact Hausdorff groupoid with the property that the range map is locally injective. The construction generalizes J. Renault’s reduced groupoid C * -algebra of an étale groupoid and has the advantage that it works for the groupoid arising from a locally i...

  14. Tales of evaluation in school mathematics

    DEFF Research Database (Denmark)

    Andrade-Molina, Melissa

    2017-01-01

    This is the tale of the power effects of evaluation in the shaping of the desired child. It maps, by using historical and cultural strategies, the circulating truths about standardized assessments, about the need for learning mathematics, and about the axiomatization of space. The analysis takes...

  15. Law as a Tale of Identity

    DEFF Research Database (Denmark)

    Schaumburg-Müller, Sten

    2010-01-01

    Understanding law as a tale of identity, indentity includes what we ought as much as what we are. Criticism of law and literature of seing literature as having precende over law which is a mere technicality. Different human rights consceptions in Denmark compared to Europe equal diffent identities....

  16. Annals of Academic Life: An Exemplary Tale

    Directory of Open Access Journals (Sweden)

    Louis Kampf

    2014-10-01

    Full Text Available The narrator of the following vignette is not to be mistaken for the author. Though the tale appears to be autobiographical, it must be a fiction. Academic institutions, as we know, are the repositories of rationality. Professors have been bequeathed the patrimony of the Enlightenment. Such evidence indicates that the events described below could not possibly have happened.

  17. Semi-étale groupoids and applications

    DEFF Research Database (Denmark)

    Thomsen, Klaus

    2010-01-01

    We associate a C * -algebra to a locally compact Hausdorff groupoid with the property that the range map is locally injective. The construction generalizes J. Renault’s reduced groupoid C * -algebra of an étale groupoid and has the advantage that it works for the groupoid arising from a locally i...

  18. Chongqing:A Tale of Two Cities

    Institute of Scientific and Technical Information of China (English)

    James H.Zhao

    2007-01-01

    @@ Chongqing is known more for its hot and spicy boiling food than for its cotton textile industry which is almost nothing when it compares with those cotton spinning giants in China's coastal provinces. Coupled with both old culture and modern textile industry, Chcongqing has both roles to perform. "A Tale of Two Cities" continues its story in a scenario of China's southwestern land...

  19. Filtering and control of stochastic jump hybrid systems

    CERN Document Server

    Yao, Xiuming; Zheng, Wei Xing

    2016-01-01

    This book presents recent research work on stochastic jump hybrid systems. Specifically, the considered stochastic jump hybrid systems include Markovian jump Ito stochastic systems, Markovian jump linear-parameter-varying (LPV) systems, Markovian jump singular systems, Markovian jump two-dimensional (2-D) systems, and Markovian jump repeated scalar nonlinear systems. Some sufficient conditions are first established respectively for the stability and performances of those kinds of stochastic jump hybrid systems in terms of solution of linear matrix inequalities (LMIs). Based on the derived analysis conditions, the filtering and control problems are addressed. The book presents up-to-date research developments and novel methodologies on stochastic jump hybrid systems. The contents can be divided into two parts: the first part is focused on robust filter design problem, while the second part is put the emphasis on robust control problem. These methodologies provide a framework for stability and performance analy...

  20. A locust-inspired miniature jumping robot.

    Science.gov (United States)

    Zaitsev, Valentin; Gvirsman, Omer; Ben Hanan, Uri; Weiss, Avi; Ayali, Amir; Kosa, Gabor

    2015-11-25

    Unmanned ground vehicles are mostly wheeled, tracked, or legged. These locomotion mechanisms have a limited ability to traverse rough terrain and obstacles that are higher than the robot's center of mass. In order to improve the mobility of small robots it is necessary to expand the variety of their motion gaits. Jumping is one of nature's solutions to the challenge of mobility in difficult terrain. The desert locust is the model for the presented bio-inspired design of a jumping mechanism for a small mobile robot. The basic mechanism is similar to that of the semilunar process in the hind legs of the locust, and is based on the cocking of a torsional spring by wrapping a tendon-like wire around the shaft of a miniature motor. In this study we present the jumping mechanism design, and the manufacturing and performance analysis of two demonstrator prototypes. The most advanced jumping robot demonstrator is power autonomous, weighs 23 gr, and is capable of jumping to a height of 3.35 m, covering a distance of 1.37 m.

  1. Mechanical jumping power in young athletes.

    Science.gov (United States)

    Viitasalo, J T; Osterback, L; Alen, M; Rahkila, P; Havas, E

    1987-09-01

    Mechanical jumping power was determined for 286 young male athletes representing six sports events and ranging in calendar and skeletal ages from 8.8 to 17.1 and from 7.8 to 18.1 years, respectively. The subjects performed successive maximal vertical jumps on a contact mat for 30 s. The number of jumps and their cumulative flight time after 15 and 30 s were used for calculations of mechanical power. The jumping performances of the young athletes were found to be reproducible from the age of 10-12 years in respect to the angular displacement of the knee and duration of contact. Absolute mechanical power, as well as power related to body weight, increased with calendar and skeletal ages. Of the anthropometric characteristics, the circumference of the thigh and body weight showed the highest correlation with mechanical power; subjects with the greatest thigh circumference and body weight having the lowest mechanical power. The subjects were divided into 'power' (track and field, gymnastics) and 'endurance' (skiing, orienteering) groups. The former reached higher mechanical power values than the latter. Mechanical power for the second 15-s jumping period was on average 4.7% lower than for the first. The events did not differ from each other in respect of the decrease in power.

  2. Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.

    Directory of Open Access Journals (Sweden)

    Kim Anthony

    Full Text Available Recent work has shown that the combinatorial use of multiple TALE activators can selectively activate certain cellular genes in inaccessible chromatin regions. In this study, we aimed to interrogate the activation potential of TALEs upon transcriptionally silenced immune genes in the context of non-immune cells. We designed a unique strategy, in which a single TALE fused to the TATA-box binding protein (TBP-TALE is coupled with multiple VP64-TALE activators. We found that our strategy is significantly more potent than multiple TALE activators alone in activating expression of IL-2 and GM-CSF in diverse cell origins in which both genes are otherwise completely silenced. Chromatin analysis revealed that the gene activation was due in part to displacement of a distinctly positioned nucleosome. These studies provide a novel epigenetic mechanism for artificial gene induction and have important implications for targeted cancer immunotherapy, DNA vaccine development, as well as rational design of TALE activators.

  3. Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.

    Science.gov (United States)

    Anthony, Kim; More, Abhijit; Zhang, Xiaoliu

    2014-01-01

    Recent work has shown that the combinatorial use of multiple TALE activators can selectively activate certain cellular genes in inaccessible chromatin regions. In this study, we aimed to interrogate the activation potential of TALEs upon transcriptionally silenced immune genes in the context of non-immune cells. We designed a unique strategy, in which a single TALE fused to the TATA-box binding protein (TBP-TALE) is coupled with multiple VP64-TALE activators. We found that our strategy is significantly more potent than multiple TALE activators alone in activating expression of IL-2 and GM-CSF in diverse cell origins in which both genes are otherwise completely silenced. Chromatin analysis revealed that the gene activation was due in part to displacement of a distinctly positioned nucleosome. These studies provide a novel epigenetic mechanism for artificial gene induction and have important implications for targeted cancer immunotherapy, DNA vaccine development, as well as rational design of TALE activators.

  4. Evaluation of Knock Behavior for Natural Gas - Gasoline Blends in a Light Duty Spark Ignited Engine

    Energy Technology Data Exchange (ETDEWEB)

    Pamminger, Michael [Argonne National Lab. (ANL), Argonne, IL (United States); Sevik, James [Argonne National Lab. (ANL), Argonne, IL (United States); Scarcelli, Riccardo [Argonne National Lab. (ANL), Argonne, IL (United States); Wallner, Thomas [Argonne National Lab. (ANL), Argonne, IL (United States); Wooldridge, Steven [Ford Motor Co., Detroit, MI (United States); Boyer, Brad [Ford Motor Co., Detroit, MI (United States); Hall, Carrie M. [Illinois Inst. of Technology, Chicago, IL (United States)

    2016-10-17

    The compression ratio is a strong lever to increase the efficiency of an internal combustion engine. However, among others, it is limited by the knock resistance of the fuel used. Natural gas shows a higher knock resistance compared to gasoline, which makes it very attractive for use in internal combustion engines. The current paper describes the knock behavior of two gasoline fuels, and specific incylinder blend ratios with one of the gasoline fuels and natural gas. The engine used for these investigations is a single cylinder research engine for light duty application which is equipped with two separate fuel systems. Both fuels can be used simultaneously which allows for gasoline to be injected into the intake port and natural gas to be injected directly into the cylinder to overcome the power density loss usually connected with port fuel injection of natural gas. Adding natural gas at wide open throttle helps to reduce knock mitigating measures and increases the efficiency and power density compared to the other gasoline type fuels with lower knock resistance. The used methods, knock intensity and number of pressure waves, do not show significant differences in knock behavior for the natural gas - gasoline blends compared to the gasoline type fuels. A knock integral was used to describe the knock onset location of the fuels tested. Two different approaches were used to determine the experimental knock onset and were compared to the knock onset delivered by the knock integral (chemical knock onset). The gasoline type fuels show good agreement between chemical and experimental knock onset. However, the natural gas -gasoline blends show higher discrepancies comparing chemical and experimental knock onset.

  5. Nonlinear regimes on polygonal hydraulic jumps

    Science.gov (United States)

    Rojas, Nicolas

    2016-11-01

    This work extends previous leading and higher order results on the polygonal hydraulic jump in the framework of inertial lubrication theory. The rotation of steady polygonal jumps is observed in the transition from one wavenumber to the next one, induced by a change in height of an external obstacle near the outer edge. In a previous publication, the study of stationary polygons is considered under the assumption that the reference frame rotates with the polygons when the number of corners change, in order to preserve their orientation. In this research work I provide a Hamiltonian approach and the stability analysis of the nonlinear oscillator that describe the polygonal structures at the jump interface, in addition to a perturbation method that enables to explain, for instance, the diversity of patterns found in experiments. GRASP, Institute of Physics, University of Liege, Belgium.

  6. Aerodynamic Jump for Long Rod Penetrators

    Directory of Open Access Journals (Sweden)

    Mark L. Bundy

    2000-04-01

    Full Text Available Aerodynamic jump for a non-spinning kinetic energy penetrator is neither a discontinuous change in the ,direction of motion at the origin of free night, nor is it the converse, i.e. a cumulativer~direc4on over a domain of infinite extent. Rather aerodynamic jump, for such a projectile, is a localised redirection of the centre of gravity motion, caused ~ the force of lift due to yaw over ther4latively short region from entry into free flight until the yaw reaches its first maximum. The primary objective of this paper is to provide answtfrs to the questions like what is aerodynamic jump, what liauses it, !lnd wh~t aspects df the flight trajectory does it refer to, or account for .

  7. Super-knock Suppression Using Split Injection in a Turbo-Charged GDI Engine

    Directory of Open Access Journals (Sweden)

    Lv Meng

    2016-01-01

    Full Text Available Super-knock, which occurs under low-speed and big load operate condition in turbo-charged gasoline direct injection (TGDI engine, is an abnormal combustion phenomenon. Due to its potential to cause degradation of the engine, super knock has become the main obstacle for increasing specific power and lowing fuel consumption of engine. In order to investigate suppress strategies of super-knock, split injection is applied on a high boosted GDI engine. The results shows that: super knock correlates to some extent with split injection; further study shows that appropriate split injection duty ratio and the end of second injection time could reduce super knock effectively.

  8. Planarity of 3,4-jump Graphs

    Institute of Scientific and Technical Information of China (English)

    魏二玲; 刘颜佩

    2004-01-01

    For a graph G of size ε≥1 and its edge-induced subgraphs H1 and H2 of size γ(1 < γ < ε), H1 is said to be obtained from H2 by an edge jump if there exist four distinct vertices u, v, ω and x in G such that (u,v)∈E(H2), (ω,x)∈E(G) - E(H2) and H1=H2 - (u, v) + (ω, x). In this article, the γ-jump graphs(r≥3) are discussed. A graph H is said to be an γ-jump graph of G if its vertices correspond to the edge induced graph of size γ in G and two vertices are adjacent if and only if one of the two corresponding subgraphs can be obtained from the other by an edge jump. For k≥2, the k-th iterated γ-jump graph Jrk(G) is defined as Jγ(Jγk-1 (G)), where Jγ1 (G) = Jγ(G). An infinite sequence {Gi} of graphs is planar if every graph Gi is planar. It is shown that there does not exist a graph G for which the sequence {J3k(G)} is planar, where k is any positive integer. Meanwhile, lim gen(J3k(G)) =∞, where gen(G) denotes the genus of a graph G, if the sequence k→∞J3k(G) is defined for every positive integer k. As for the 4-jump graph of a graph G,{J4k(G)} is planar if and only if G = C5. For γ≥5, whether the fix graph of the sequence {Jγk(G))exists is determined.

  9. A New World to Discover-Grimm’s Fairy Tales

    Institute of Scientific and Technical Information of China (English)

    莫槟菱

    2014-01-01

    Nowadays, the fairy tales have been on hot discussion. Some say that the very original Grimm's fairy tales is capricious that we may be more cautious whether it's suitable for children. With the rethinking of fairy tales, many other scholars argue that the fairy tales can be valuable with its hidden German customs in the original version and the current versions are acceptable to children.The hot discussion raises our thinking. This new discussing wave may indicate something at a degree that the Grimm’s Fairy Tales is worthy going deeper to study. We think that the Grimm's ferry tales is valuable for its pure essence and the German culture it hides that even adults should read it. Children can read the current version of Grimm's Fairy Tales with their innocence, getting the basic judging system of good and bad. The core question is that Adults also should pick it up. That’s because usually people will find that all the experiences and reasons can be dated back to the simple truths in fairy tales. Meantime, the Grimm's Fairy Tales reflects lots of unthinkable customs and culture. The only thing we need to do is try to find new aspects and directions to explore the classic. With the spiritual and academic help, shouldn't the Grimm's fairy tales be necessary for both children and adults to read?

  10. Spectral Analysis of Diffusions with Jump Boundary

    CERN Document Server

    Kolb, Martin

    2011-01-01

    In this paper we consider one-dimensional diffusions with constant coefficients in a finite interval with jump boundary and a certain deterministic jump distribution. We use coupling methods in order to identify the spectral gap in the case of a large drift and prove that that there is a threshold drift above which the bottom of the spectrum no longer depends on the drift. As a Corollary to our result we are able to answer two questions concerning elliptic eigenvalue problems with non-local boundary conditions formulated previously by Iddo Ben-Ari and Ross Pinsky.

  11. Aerodynamic Jump for Long Rod Penetrators

    OpenAIRE

    Mark L. Bundy

    2000-01-01

    Aerodynamic jump for a non-spinning kinetic energy penetrator is neither a discontinuous change in the ,direction of motion at the origin of free night, nor is it the converse, i.e. a cumulativer~direc4on over a domain of infinite extent. Rather aerodynamic jump, for such a projectile, is a localised redirection of the centre of gravity motion, caused ~ the force of lift due to yaw over ther4latively short region from entry into free flight until the yaw reaches its first maximum. The primary...

  12. Knock Detection in Spark Ignition Engines Base on Complementary Ensemble Empirical Mode Decomposition-Hilbert Transform

    Directory of Open Access Journals (Sweden)

    Fengrong Bi

    2016-01-01

    Full Text Available In spark ignition engines, knock onset limits the maximum spark advance. An inaccurate identification of this limit penalises the fuel conversion efficiency. Thus knock feature extraction is the key of closed-loop control of ignition in spark ignition engine. This paper reports an investigation of knock detection in spark ignition (SI engines using CEEMD-Hilbert transform based on the engine cylinder pressure signals and engine cylinder block vibration signals. Complementary Ensemble Empirical Mode Decomposition (CEEMD was used to decompose the signal and detect knock characteristic. Hilbert transform was used to analyze the frequency information of knock characteristic. The result shows that, for both of cylinder pressure signals and vibration signals, the CEEMD algorithm could extract the knock characteristic, and the Hilbert transform result shows that the energy of knock impact areas has the phenomenon of frequency concentration in both cylinder pressure signal and cylinder block vibration signal. At last, the knock window is then determined, based on which a new knock intensity evaluation factor K is propose, and it can accurately distinguish between heavy knock, light knock, and normal combustion three states.

  13. Method and device for determining the knock rating of motor fuels

    Energy Technology Data Exchange (ETDEWEB)

    Kjuregyan, S.K.; Kazarian, S.A.; Dovlatov, I.A.

    1996-03-14

    The invention relates to the oil refining and petrochemical industry and concerns in particular techniques for determining the knock rating of motor fuels. The proposed method of determining the knock rating of motor fuels involves the thermostatic control of a reaction vessel of constant volume, feeding the fuel-air mixture into the vessel, atomization of the mixture under excess pressure, and ignition of the mixture. The knock rating is indicated by the intensity of the knocking which in turn is determined from the magnitude of the signal from a knocking sensor in the reaction vessel. The proposed device for determining the knock rating of motor fuels comprises a reaction vessel whith inlet and outlet valves and provided with means of thermostatic control. A spark plug is provided in the reaction vessel and a knock sensor is arranged opposite the spark plug. (author)

  14. Directed evolution of the TALE N-terminal domain for recognition of all 5' bases.

    Science.gov (United States)

    Lamb, Brian M; Mercer, Andrew C; Barbas, Carlos F

    2013-11-01

    Transcription activator-like effector (TALE) proteins can be designed to bind virtually any DNA sequence. General guidelines for design of TALE DNA-binding domains suggest that the 5'-most base of the DNA sequence bound by the TALE (the N0 base) should be a thymine. We quantified the N0 requirement by analysis of the activities of TALE transcription factors (TALE-TF), TALE recombinases (TALE-R) and TALE nucleases (TALENs) with each DNA base at this position. In the absence of a 5' T, we observed decreases in TALE activity up to >1000-fold in TALE-TF activity, up to 100-fold in TALE-R activity and up to 10-fold reduction in TALEN activity compared with target sequences containing a 5' T. To develop TALE architectures that recognize all possible N0 bases, we used structure-guided library design coupled with TALE-R activity selections to evolve novel TALE N-terminal domains to accommodate any N0 base. A G-selective domain and broadly reactive domains were isolated and characterized. The engineered TALE domains selected in the TALE-R format demonstrated modularity and were active in TALE-TF and TALEN architectures. Evolved N-terminal domains provide effective and unconstrained TALE-based targeting of any DNA sequence as TALE binding proteins and designer enzymes.

  15. Recovery Outline: New Mexico Jumping Mouse (Zapus hudsonius luteus)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this recovery outline is to provide an interim strategy to guide the conservation and recovery of the New Mexico meadow jumping mouse (jumping mouse)...

  16. TALE proteins search DNA using a rotationally decoupled mechanism.

    Science.gov (United States)

    Cuculis, Luke; Abil, Zhanar; Zhao, Huimin; Schroeder, Charles M

    2016-10-01

    Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins used extensively for gene editing. Despite recent progress, however, little is known about their sequence search mechanism. Here, we use single-molecule experiments to study TALE search along DNA. Our results show that TALEs utilize a rotationally decoupled mechanism for nonspecific search, despite remaining associated with DNA templates during the search process. Our results suggest that the protein helical structure enables TALEs to adopt a loosely wrapped conformation around DNA templates during nonspecific search, facilitating rapid one-dimensional (1D) diffusion under a range of solution conditions. Furthermore, this model is consistent with a previously reported two-state mechanism for TALE search that allows these proteins to overcome the search speed-stability paradox. Taken together, our results suggest that TALE search is unique among the broad class of sequence-specific DNA-binding proteins and supports efficient 1D search along DNA.

  17. Rapid and accurate synthesis of TALE genes from synthetic oligonucleotides.

    Science.gov (United States)

    Wang, Fenghua; Zhang, Hefei; Gao, Jingxia; Chen, Fengjiao; Chen, Sijie; Zhang, Cuizhen; Peng, Gang

    2016-01-01

    Custom synthesis of transcription activator-like effector (TALE) genes has relied upon plasmid libraries of pre-fabricated TALE-repeat monomers or oligomers. Here we describe a novel synthesis method that directly incorporates annealed synthetic oligonucleotides into the TALE-repeat units. Our approach utilizes iterative sets of oligonucleotides and a translational frame check strategy to ensure the high efficiency and accuracy of TALE-gene synthesis. TALE arrays of more than 20 repeats can be constructed, and the majority of the synthesized constructs have perfect sequences. In addition, this novel oligonucleotide-based method can readily accommodate design changes to the TALE repeats. We demonstrated an increased gene targeting efficiency against a genomic site containing a potentially methylated cytosine by incorporating non-conventional repeat variable di-residue (RVD) sequences.

  18. Understanding the Physics of Bungee Jumping

    Science.gov (United States)

    Heck, Andre; Uylings, Peter; Kedzierska, Ewa

    2010-01-01

    Changing mass phenomena like the motion of a falling chain, the behaviour of a falling elastic bar or spring, and the motion of a bungee jumper surprise many a physicist. In this article we discuss the first phase of bungee jumping, when the bungee jumper falls, but the bungee rope is still slack. In instructional material this phase is often…

  19. Jumping Rope at Day of Play

    Science.gov (United States)

    2005-01-01

    Sarah Dastugue, 11, leaps in the air as Libby Knox, 9, swings a jump rope. The children were participants in Nickelodeon's Worldwide Day of Play celebration at Stennis Space Center (SSC) on Oct. 1. On the day of the event, children all over the world participate in physical activities as part of the celebration.

  20. Understanding the physics of bungee jumping

    NARCIS (Netherlands)

    Heck, A.; Uylings, P.; Kędzierska, E.

    2010-01-01

    Changing mass phenomena like the motion of a falling chain, the behaviour of a falling elastic bar or spring, and the motion of a bungee jumper surprise many a physicist. In this article we discuss the first phase of bungee jumping, when the bungee jumper falls, but the bungee rope is still slack.

  1. Jumping on the Social Media Bandwagon

    Science.gov (United States)

    Blakeslee, Lori

    2012-01-01

    Should a school district jump on the social media bandwagon? Yes! Social media provide a low-cost way to communicate school district priorities, influence decision makers, and tell its story without filters. Equally important, social media are where constituents are spending a lot of their time. With more than 800 million members, Facebook is an…

  2. Jumping on the Social Media Bandwagon

    Science.gov (United States)

    Blakeslee, Lori

    2012-01-01

    Should a school district jump on the social media bandwagon? Yes! Social media provide a low-cost way to communicate school district priorities, influence decision makers, and tell its story without filters. Equally important, social media are where constituents are spending a lot of their time. With more than 800 million members, Facebook is an…

  3. Jumping-droplet electrostatic energy harvesting

    Science.gov (United States)

    Miljkovic, Nenad; Preston, Daniel J.; Enright, Ryan; Wang, Evelyn N.

    2014-07-01

    Micro- and nanoscale wetting phenomena have been an active area of research due to its potential for improving engineered system performance involving phase change. With the recent advancements in micro/nanofabrication techniques, structured surfaces can now be designed to allow condensing coalesced droplets to spontaneously jump off the surface due to the conversion of excess surface energy into kinetic energy. In addition to being removed at micrometric length scales (˜10 μm), jumping water droplets also attain a positive electrostatic charge (˜10-100 fC) from the hydrophobic coating/condensate interaction. In this work, we take advantage of this droplet charging to demonstrate jumping-droplet electrostatic energy harvesting. The charged droplets jump between superhydrophobic copper oxide and hydrophilic copper surfaces to create an electrostatic potential and generate power during formation of atmospheric dew. We demonstrated power densities of ˜15 pW/cm2, which, in the near term, can be improved to ˜1 μW/cm2. This work demonstrates a surface engineered platform that promises to be low cost and scalable for atmospheric energy harvesting and electric power generation.

  4. Caracterización del 'Knock out' en Boxeo

    OpenAIRE

    Pic-Aguilar, M.; Sánchez-López, C.R.; Blanco Villaseñor, Ángel

    2016-01-01

    El objetivo de este trabajo es identificar las cuatro últimas acciones motrices emitidas (golpes) por boxeadores campeones del mundo de los pesos pesados y así poder caracterizar el 'Knock out' en boxeo. Para ello, hemos desarrollado una herramienta de observación que consta de cuatro criterios y 35 categorías. Para la selección de la muestra se tuvo en cuenta dos requisitos: haberse proclamado campeón del mundo del peso pesado durante el período que comprende 1921-2007 (desde Jack Dempsey ha...

  5. DISCONTINUOUS FLOW OF TURBID DENSITY CURRENTS Ⅱ. INTERNAL HYDRAULIC JUMP

    Institute of Scientific and Technical Information of China (English)

    Jiahua FAN

    2005-01-01

    Traveling and stationary internal hydraulic jumps in density currents with positive or negative entrainment coefficients were analyzed based on simple assumptions. An expression of internal hydraulic jumps with entrainment coefficients was derived. Experimental data, published in literature, of stationary internal hydraulic jumps in turbid, thermal and saline density currents including measured values of water entrainment were used to compare with theory. Comparison was also made of traveling internal hydraulic jumps between measured data and theory.

  6. The Development of TALE Nucleases for Biotechnology.

    Science.gov (United States)

    Ousterout, David G; Gersbach, Charles A

    2016-01-01

    The development of a facile genome engineering technology based on transcription activator-like effector nucleases (TALENs) has led to significant advances in diverse areas of science and medicine. In this review, we provide a broad overview of the development of TALENs and the use of this technology in basic science, biotechnology, and biomedical applications. This includes the discovery of DNA recognition by TALEs, engineering new TALE proteins to diverse targets, general advances in nuclease-based editing strategies, and challenges that are specific to various applications of the TALEN technology. We review examples of applying TALENs for studying gene function and regulation, generating disease models, and developing gene therapies. The current status of genome editing and future directions for other uses of these technologies are also discussed.

  7. Telling business stories as fellowship-tales

    DEFF Research Database (Denmark)

    Smith, Robert; Neergaard, Helle

    2015-01-01

    Purpose – This paper aims to explore the “Fellowship-Tale” as an alternative tale type for narrating entrepreneur stories. The authors illustrate this by telling the Pilgrim business story. It is common for the deeds of men who founded businesses to be narrated as heroic entrepreneur stories...... – The research indicates that “fellowship-tales” provide a viable and credible alternative to the fairy-tale rendition common in entrepreneur and business stories. Research limitations/implications – An obvious limitation is that one merely swaps one narrative framework for another, albeit it offers dissenting....../value – A key contribution is to challenge the hegemony of a dominant and embedded social construct allowing new understandings to emerge via a novel combination of research methodologies...

  8. The last half-repeat of transcription activator-like effector (TALE) is dispensable and thereby TALE-based technology can be simplified.

    Science.gov (United States)

    Zheng, Chong-Ke; Wang, Chun-Lian; Zhang, Xiao-Ping; Wang, Fu-Jun; Qin, Teng-Fei; Zhao, Kai-Jun

    2014-09-01

    To activate the expression of host genes that contribute to pathogen growth, pathogenic Xanthomonas bacteria inject their transcription activator-like effectors (TALEs) into plant cells and the TALEs bind to target gene promoters by the central repeat region consisting of near-perfect 34-amino-acid repeats (34-aa repeats). Based on the recognition codes between the 34-aa repeats and the targeted nucleotides, TALE-based technologies, such as designer TALEs (dTALEs) and TALE nucleases (TALENs), have been developed. Amazingly, every natural TALE invariantly has a truncated last half-repeat (LHR) at the end of the 34-aa repeats. Consequently, all the reported dTALEs and TALENs also harbour their LHRs. Here, we show that the LHRs in dTALEs are dispensable for the function of gene activation by both transient expression assays in Nicotiana benthamiana and gene-specific targeting in the rice genome, indicating that TALEs might originate from a single progenitor. In the light of this finding, we demonstrate that dTALEs can be constructed through two simple steps. Moreover, the activation strengths of dTALEs lacking the LHR are comparable with those of dTALEs harbouring the LHR. Our results provide new insights into the origin of natural TALEs, and will facilitate the simplification of the design and assembly of TALE-based tools, such as dTALEs and TALENs, in the near future.

  9. Freud's Psychoanalysis of The Tell-Tale Heart

    Institute of Scientific and Technical Information of China (English)

    杜红云; 梁静

    2014-01-01

    Edgar Allan Poe is a famous American poet, short fiction writer and critic. He is good at writing horror tale and detective story. Many of his short stories show the narrator's abnormal mind. The Tell-Tale Heart is one of his famous short stories. This paper will analyze Poe's The Tell-Tale Heart by using Freud's psychoanalysis theory:the three-level personality.

  10. Freud’s Psychoanalysis of The Tell-Tale Heart

    Institute of Scientific and Technical Information of China (English)

    杜红云; 梁静

    2014-01-01

    Edgar Allan Poe is a famous American poet,shor fiction writer and critic.He is good at writing horror tale and detective story.Many of his short stories show the narrator’s abnormal mind.The Tell-Tale Heart is one of his famous shor stories.This paper will analyze Poe’s The Tell-Tale Heart by using Freud’s psychoanalysis theory:the three-level personality.

  11. Meeting the dark: autobiography in Hawthorne's unfinished tales.

    Science.gov (United States)

    Loughman, C

    1992-12-01

    This essay discusses the autobiographical implications of Nathaniel Hawthorne's last, unfinished tales. Biographical documents, as well as the tales, demonstrate that Hawthorne's personal condition shaped the characters and ideas in his fiction, particularly the aged protagonist, the meditations on old age and death, and the quest for immortality. The conflict between the moral vision in the tales and his personal attitude toward old age and death caused creative difficulties that he could not overcome.

  12. Option Valuation with Observable Volatility and Jump Dynamics

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Feunou, Bruno; Jeon, Yoontae

    Under very general conditions, the total quadratic variation of a jump-diffusion process can be decomposed into diffusive volatility and squared jump variation. We use this result to develop a new option valuation model in which the underlying asset price exhibits volatility and jump intensity dy...

  13. Determination of jumps for functions via derivative Gabor series

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ying-ying; SHI Xian-liang

    2009-01-01

    Recently, Shi Xianliang and Hu Lan published the method of concentration factors for determination of jumps of functions via MCM conjugate wavelets. Usually, it is difficult to calculate the Hilbert transform of general window functions. The aim of this paper is to discuss determination of jumps for functions based on derivative Gabor series. The results will simplify the calculation of jump values.

  14. Morality's ugly implications in Oscar Wilde's fairy tales.

    Science.gov (United States)

    Jones, Justin T

    2011-01-01

    In Oscar Wilde's two volumes of fairy tales, "The Happy Prince" and Other Tales (1888) and A House of Pomegranates (1891), many central characters meet with premature death or physical disfigurement after learning a bourgeois moral lesson. In an attempt to explain this unconventional phenomenon in the fairy tale tradition, this essay examines Wilde's stories through the lens of his aesthetic ideology and demonstrates how the superficial morality of the Victorian bourgeoisie corrodes each tale's aesthetic integrity, causing the characters to either deny morality outright, assume the guise of Christian philanthropy, or die as the result of their moral reformation.

  15. Intertextuality in the Tales of Rabbi Nahman of Bratslav

    DEFF Research Database (Denmark)

    Schleicher, Marianne

    Until 1806, Rabbi Nahman of Bratslav (1772-1810) disseminated his thoughts on redemption through homilies. In 1806, however, Nahman chose the genre of tales as an additional and innovative means of religious discourse. An academic close reading of all of the tales, known as Sippurey Ma'asiyot, has...... not yet been undertaken. As the first comprehensive scholarly work on the whole selection of tales and contrary to previous scholarship, this book does not reduce the tales to biographical expressions of Nahman's tormented soul and messianic aspirations. Instead, it treats them as religious literature...

  16. Literary fairy tale Twinkle Sleepyhead in different media

    OpenAIRE

    Zupanec, Monika

    2014-01-01

    The first part of diploma work is theoretically oriented. Basic features of Twinkle Sleepyhead and its great successes are discussed. The literary fairy tale Twinkle Sleepyhead is presented as a fairy tale and compared with the shortened version of the fairy tale. Further, it is compared with the radio play (1952), with the puppet show at Ljubljana Puppet Theatre (2009) and with the virtual puppet show at Mini Theatre (2012). The basis of the fairy tale is the same in all forms; however, diff...

  17. Cylinder pressure based knock control for analysis of knock control applications and automatic ignition angle applications; Zylinderdruckbasierte Klopfregelung zur Bewertung von Klopfregelungsapplikationen und automatisierten Zuendwinkelapplikationen

    Energy Technology Data Exchange (ETDEWEB)

    Kempf, S.; Goebels, J.; Sloboda, R. [Robert Bosch GmbH, Schwieberdingen (Germany)

    2006-07-01

    Today, knock control is part of the modern standard engine management system. The trend towards higher performance, lower fuel consumption and legal limitation of emissions makes it necessary to reliably detect knocking combustions at all operating conditions during the entire service life of the vehicle. Ranges in which the knock control needs to be limited or even deactivated due to detection problems can no longer be accepted. In order to ensure this detection quality, it must be made possible to be able to evaluate independently and comprehensibly the quality of the knock control calibration. The development started out from an analog evaluation strategy for the assessment of knock sensor signals and has now reached the digital signal analysis with freely programmable digital filters and a parallel evaluation of up to three frequency ranges in the BOSCH engine management system. The use of the BOSCH Knock-Intensity-Detector 2 (KID2) and the KC-tool chain offers an efficient and productive calibration. In order to be able to perform a quality assessment that is independent of the KC-tool chain, a Matlab based tool was developed. On the one hand, this tool allows a knock-controlled engine operation based on cylinder-pressure while the knock control based on structure-borne signal is disabled and on the other hand it is capable of assessing the current knock control with an additionally enabled and calibrated knock control which is based on structure-borne signal. This assessment can be used to verify a current calibration or e. g. to assess the influence by component variations on the structure borne signal based knock detection. Furthermore, a base was thus provided to perform an automated ignition angle calibration. For this, the cylinder-pressure curve is sampled and by determining the 50% mass fraction burned or the knock limit, the optimum ignition timing will be determined. The approach to this optimum ignition timing is not done manually but automated

  18. Lift-off dynamics in a simple jumping robot

    CERN Document Server

    Aguilar, Jeffrey; Wiesenfeld, Kurt; Goldman, Daniel I

    2012-01-01

    We study vertical jumping in a simple robot comprising an actuated mass-spring arrangement. The actuator frequency and phase are systematically varied to find optimal performance. Optimal jumps occur above and below (but not at) the robot's resonant frequency $f_0$. Two distinct jumping modes emerge: a simple jump which is optimal above $f_0$ is achievable with a squat maneuver, and a peculiar stutter jump which is optimal below $f_0$ is generated with a counter-movement. A simple dynamical model reveals how optimal lift-off results from non-resonant transient dynamics.

  19. Dynamics of Coalescence-Induced Jumping Water Droplets

    CERN Document Server

    Miljkovic, Nenad; Enright, Ryan; Wang, Evelyn N

    2013-01-01

    This fluid dynamics video shows the different interaction mechanisms of coalescence-induced droplet jumping during condensation on a nanostructured superhydrophobic surface. High speed imaging was used to show jumping behavior on superhydrophobic copper oxide and carbon nanotube surfaces. Videos demonstrating multi-jumping droplets, jumping droplet return to the surface, and droplet-droplet electrostatic repulsions were analyzed. Experiments using external electric fields in conjunction with high speed imaging in a custom built experimental chamber were used to show that all coalescence-induced jumping droplets on superhydrophobic surfaces become positively charged upon leaving the surface, which is detailed in the video.

  20. Effect of early training on the jumping technique of horses.

    Science.gov (United States)

    Santamaría, Susana; Bobbert, Maarten F; Back, Willem; Barneveld, Ab; van Weeren, P Rene

    2005-03-01

    To investigate the effects of early training for jumping by comparing the jumping technique of horses that had received early training with that of horses raised conventionally. 40 Dutch Warmblood horses. The horses were analyzed kinematically during free jumping at 6 months of age. Subsequently, they were allocated into a control group that was raised conventionally and an experimental group that received 30 months of early training starting at 6 months of age. At 4 years of age, after a period of rest in pasture and a short period of training with a rider, both groups were analyzed kinematically during free jumping. Subsequently, both groups started a 1-year intensive training for jumping, and at 5 years of age, they were again analyzed kinematically during free jumping. In addition, the horses competed in a puissance competition to test maximal performance. Whereas there were no differences in jumping technique between experimental and control horses at 6 months of age, at 4 years, the experimental horses jumped in a more effective manner than the control horses; they raised their center of gravity less yet cleared more fences successfully than the control horses. However, at 5 years of age, these differences were not detected. Furthermore, the experimental horses did not perform better than the control horses in the puissance competition. Specific training for jumping of horses at an early age is unnecessary because the effects on jumping technique and jumping capacity are not permanent.

  1. Biomechanical Analysis of the Jump Shot in Basketball

    Directory of Open Access Journals (Sweden)

    Struzik Artur

    2014-10-01

    Full Text Available Basketball players usually score points during the game using the jump shot. For this reason, the jump shot is considered to be the most important element of technique in basketball and requires a high level of performance. The aim of this study was to compare the biomechanical characteristics of the lower limbs during a jump shot without the ball and a countermovement jump without an arm swing. The differences between variables provide information about the potential that an athlete can utilise during a game when performing a jump shot. The study was conducted among 20 second-league basketball players by means of a Kistler force plate and the BTS SMART system for motion analysis. The variables measured included the take-off time, mean power, peak power, relative mean power, jump height, maximum landing force and calculated impact ratio. Surprisingly, more advantageous variables were found for the jump shot. This finding suggests a very high performance level in the jump shot in the studied group and a maximum utilisation of their motor abilities. Both types of jumps were characterised by high mean and peak power values and average heights. The high forces at landing, which result in considerable impact ratios, may have prompted the studied group to land softly. Use of the countermovement jump without an arm swing is recommended to assess and predict the progression of player’s jumping ability

  2. System and method for controlling engine knock using electro-hydraulic valve actuation

    Science.gov (United States)

    Brennan, Daniel G

    2013-12-10

    A control system for an engine includes a knock control module and a valve control module. The knock control module adjusts a period that one or more of an intake valve and an exhaust valve of a cylinder are open based on engine knock corresponding to the cylinder. The valve control module, based on the adjusted period, controls the one or more of the intake valve and the exhaust valve using one or more hydraulic actuators.

  3. Scaled Jump in Gravity-Reduced Virtual Environments.

    Science.gov (United States)

    Kim, MyoungGon; Cho, Sunglk; Tran, Tanh Quang; Kim, Seong-Pil; Kwon, Ohung; Han, JungHyun

    2017-04-01

    The reduced gravity experienced in lunar or Martian surfaces can be simulated on the earth using a cable-driven system, where the cable lifts a person to reduce his or her weight. This paper presents a novel cable-driven system designed for the purpose. It is integrated with a head-mounted display and a motion capture system. Focusing on jump motion within the system, this paper proposes to scale the jump and reports the experiments made for quantifying the extent to which a jump can be scaled without the discrepancy between physical and virtual jumps being noticed by the user. With the tolerable range of scaling computed from these experiments, an application named retargeted jump is developed, where a user can jump up onto virtual objects while physically jumping in the real-world flat floor. The core techniques presented in this paper can be extended to develop extreme-sport simulators such as parasailing and skydiving.

  4. Capture of Trojans by Jumping Jupiter

    CERN Document Server

    Nesvorny, David; Morbidelli, Alessandro

    2013-01-01

    Jupiter Trojans are thought to be survivors of a much larger population of planetesimals that existed in the planetary region when planets formed. They can provide important constraints on the mass and properties of the planetesimal disk, and its dispersal during planet migration. Here we tested a possibility that the Trojans were captured during the early dynamical instability among the outer planets (aka the Nice model), when the semimajor axis of Jupiter was changing as a result of scattering encounters with an ice giant. The capture occurs in this model when Jupiter's orbit and its Lagrange points become radially displaced in a scattering event and fall into a region populated by planetesimals (that previously evolved from their natal transplanetary disk to ~5 AU during the instability). Our numerical simulations of the new capture model, hereafter jump capture, satisfactorily reproduce the orbital distribution of the Trojans and their total mass. The jump capture is potentially capable of explaining the ...

  5. Children's Responses to Psychological Maltreatment in Fairy Tales.

    Science.gov (United States)

    Paris, Norma Jean

    This paper presents and discusses the responses of a class of first-grade students and a class of fourth-grade students to the elements of psychological maltreatment in the fairy tales "Cinderella" and "The Twelve Months." Responses of the first-grade students indicate that both boys and girls felt that the fairy tale heroine let herself be…

  6. E-Classical Fairy Tales: Multimedia Builder as a Tool

    Science.gov (United States)

    Eteokleous, Nikleia; Ktoridou, Despo; Tsolakidis, Symeon

    2011-01-01

    The study examines pre-service teachers' experiences in delivering a traditional-classical fairy tale using the Multimedia Builder software, in other words an e-fairy tale. A case study approach was employed, collecting qualitative data through classroom observations and focus groups. The results focus on pre-service teachers' reactions, opinions,…

  7. The magic of fairy tales: psychodynamic and developmental perspectives.

    Science.gov (United States)

    Lubetsky, M J

    1989-01-01

    The telling of fairy tales is one way to elicit a child's inner thoughts and feelings, expose conflicts and frustrations, reduce anxiety, and gain mastery over developmental tasks. This paper will review the meaning, usefulness, and importance of fairy tales by discussing three selections from the psychodynamic and developmental perspectives.

  8. The Indecisive Feminist: Study of Anne Sexton's Revisionist Fairy Tales

    Science.gov (United States)

    Mohammed, Nadia Fayidh

    2015-01-01

    Fairy tales to female writers are major resource for their abundant writings, but for the feminist poets since 1960s, they become essential subject matter to often deal with in their literary production. With the motivation to address the conventional tradition of patriarchal society, and re-address the stereotype females inhabiting these tales,…

  9. Fairy Tales and Foreign Languages: Ever the Twain Shall Meet

    Science.gov (United States)

    Davidheiser, James C.

    2007-01-01

    Fairy tales are not new to foreign language instructors, but on occasion they have been considered wither exoteric or unworthy of class time. Yet today there is a resurgence of interest in fairy tales and a rebirth of their use in the arts, which may serve foreign language instructors. This article presents historical background to inform…

  10. Normativity in Fairy Tales: Scope, Range and Modes of Communication

    Science.gov (United States)

    Hohr, Hansjörg

    2013-01-01

    The article studies in three steps how the fairy tale articulates its normative content and what the educational consequence of this kind of communication is. First, the articulation of normativity in fictional literature in general is discussed. Second, the specific mode in which the fairy tale articulates its normativity is studied according to…

  11. The Comment on the Appeal of The Knight's Tales

    Institute of Scientific and Technical Information of China (English)

    贺小华

    2010-01-01

    @@ Geoffrey Chaucer was an English poet, his best known work is The Canterbury Tales. During which, Chaucer described the pilgrimage undertaken by people on horseback to the shrine of Archbishop Beckett at the Canterbury Cathedrale, with each tolling a story to pass the time. "The Knight'sTales" is one among those stories with exciting plot, and is full of turns and twists.

  12. In Support of Fairy Tales for Language Instruction.

    Science.gov (United States)

    Leisher, Johanna

    1984-01-01

    Describes a technique used to teach German to children whereby the children learn a fairy tale in German (in this case, "Hansel and Gretel") and then present the fairy tale as a play. In this way, the students learn basic vocabulary and expressions, German music, and simple folk dances. (SED)

  13. Using Fairy Tales to Change Perceptions of Self and Others.

    Science.gov (United States)

    Gornicki, Sylvia B.

    Fairy tales can be used in the classroom to promote normal growth and development as well as carry a message of hope and faith in the strength and goodness of humans. Because fairy tales are imaginative literature, readers can safely experience and work through scary situations which are analogous to situations in real life. Bibliotherapy refers…

  14. TALE factors poise promoters for activation by Hox proteins.

    Science.gov (United States)

    Choe, Seong-Kyu; Ladam, Franck; Sagerström, Charles G

    2014-01-27

    Hox proteins form complexes with TALE cofactors from the Pbx and Prep/Meis families to control transcription, but it remains unclear how Hox:TALE complexes function. Examining a Hoxb1b:TALE complex that regulates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the hoxb1a promoter already during blastula stages. These TALE factors recruit histone-modifying enzymes to promote an active chromatin profile at the hoxb1a promoter and also recruit RNA polymerase II (RNAPII) and P-TEFb. However, in the presence of TALE factors, RNAPII remains phosphorylated on serine 5 and hoxb1a transcription is inefficient. By gastrula stages, Hoxb1b binds together with TALE factors to the hoxb1a promoter. This triggers P-TEFb-mediated transitioning of RNAPII to the serine 2-phosphorylated form and efficient hoxb1a transcription. We conclude that TALE factors access promoters during early embryogenesis to poise them for activation but that Hox proteins are required to trigger efficient transcription.

  15. Sex Differences in Countermovement Jump Phase Characteristics

    Directory of Open Access Journals (Sweden)

    John J. McMahon

    2017-01-01

    Full Text Available The countermovement jump (CMJ is commonly used to explore sex differences in neuromuscular function, but previous studies have only reported gross CMJ measures or have partly examined CMJ phase characteristics. The purpose of this study was to explore differences in CMJ phase characteristics between male and female athletes by comparing the force-, power-, velocity-, and displacement-time curves throughout the entire CMJ, in addition to gross measures. Fourteen men and fourteen women performed three CMJs on a force platform from which a range of kinetic and kinematic variables were calculated via forward dynamics. Jump height (JH, reactive strength index modified, relative peak concentric power, and eccentric and concentric displacement, velocity, and relative impulse were all greater for men (g = 0.58–1.79. Relative force-time curves were similar between sexes, but relative power-, velocity-, and displacement-time curves were greater for men at 90%–95% (immediately before and after peak power, 47%–54% (start of eccentric phase and 85%–100% (latter half of concentric phase, and 65%–87% (bottom of countermovement and initial concentric phase of normalized jump time, respectively. The CMJ distinguished between sexes, with men demonstrating greater JH through applying a larger concentric impulse and, thus, achieving greater velocity throughout most of the concentric phase, including take-off.

  16. Quantum jumps of a fluxonium qubit

    Science.gov (United States)

    Vool, U.; Pop, I. M.; Sliwa, K.; Abdo, B.; Brecht, T.; Shankar, S.; Hatridge, M.; Schoelkopf, R. J.; Mirrahimi, M.; Glazman, L.; Devoret, M. H.

    2014-03-01

    The fluxonium qubit has recently been shown to have energy relaxation time (T1) of the order of 1 ms, limited by quasiparticle dissipation. With the addition of a Josephson Parametric Converter (JPC) to the experiment, trajectories corresponding to quantum jumps between the ground and 1st excited state can be measured, thus allowing the observation of the qubit decay in real time instead of that of an ensemble average. Our measurement fidelity with the JPC is in excess of 98% for an acquisition time of 5 us and we can thus continuously monitor the quantum jumps of the qubit in equilibrium with its environment in a time much shorter than its average relaxation time. We observe in our sample a jump statistics that varies from being completely Poissonian with a long (500 us) mean time in the ground state to being highly non-Poissonian with short (100 us) mean time in the ground state. The changes between these regimes occur on time scales of seconds, minutes and even hours. We have studied this effect and its relation to quasiparticle dynamics by injecting quasiparticles with a short intense microwave pulse and by seeding quasiparticle-trapping vortices with magnetic field. Work supported by: IARPA, ARO, and NSF.

  17. POTENTIAL FOR NON-CONTACT ACL INJURY BETWEEN STEP-CLOSE-JUMP AND HOP-JUMP TASKS

    Directory of Open Access Journals (Sweden)

    Li-I Wang

    2010-03-01

    Full Text Available This study aimed to compare the kinematics and kinetics during the landing of hop-jump and step-close-jump movements in order to provide further inferring that the potential risk of ACL injuries. Eleven elite male volleyball players were recruited to perform hop-jump and step-close-jump tasks. Lower extremity kinematics and ground reaction forces during landing in stop-jump tasks were recorded. Lower extremity kinetics was calculated by using an inverse dynamic process. Step-close-jump tasks demonstrated smaller peak proximal tibia anterior shear forces during the landing phase. In step-close-jump tasks, increasing hip joint angular velocity during initial foot-ground contact decreased peak posterior ground reaction force during the landing phase, which theoretically could reduce the risk of ACL injury

  18. Chemical Methods to Knock Down the Amyloid Proteins

    Directory of Open Access Journals (Sweden)

    Na Gao

    2017-06-01

    Full Text Available Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies.

  19. An Efficient Interpolation Technique for Jump Proposals in Reversible-Jump Markov Chain Monte Carlo Calculations

    CERN Document Server

    Farr, Will M

    2011-01-01

    Selection among alternative theoretical models given an observed data set is an important challenge in many areas of physics and astronomy. Reversible-jump Markov chain Monte Carlo (RJMCMC) is an extremely powerful technique for performing Bayesian model selection, but it suffers from a fundamental difficulty: it requires jumps between model parameter spaces, but cannot retain a memory of the favored locations in more than one parameter space at a time. Thus, a naive jump between parameter spaces is unlikely to be accepted in the MCMC algorithm and convergence is correspondingly slow. Here we demonstrate an interpolation technique that uses samples from single-model MCMCs to propose inter-model jumps from an approximation to the single-model posterior of the target parameter space. The interpolation technique, based on a kD-tree data structure, is adaptive and efficient in arbitrary dimensions. We show that our technique leads to dramatically improved convergence over naive jumps in an RJMCMC, and compare it ...

  20. An efficient interpolation technique for jump proposals in reversible-jump Markov chain Monte Carlo calculations.

    Science.gov (United States)

    Farr, W M; Mandel, I; Stevens, D

    2015-06-01

    Selection among alternative theoretical models given an observed dataset is an important challenge in many areas of physics and astronomy. Reversible-jump Markov chain Monte Carlo (RJMCMC) is an extremely powerful technique for performing Bayesian model selection, but it suffers from a fundamental difficulty and it requires jumps between model parameter spaces, but cannot efficiently explore both parameter spaces at once. Thus, a naive jump between parameter spaces is unlikely to be accepted in the Markov chain Monte Carlo (MCMC) algorithm and convergence is correspondingly slow. Here, we demonstrate an interpolation technique that uses samples from single-model MCMCs to propose intermodel jumps from an approximation to the single-model posterior of the target parameter space. The interpolation technique, based on a kD-tree data structure, is adaptive and efficient in modest dimensionality. We show that our technique leads to improved convergence over naive jumps in an RJMCMC, and compare it to other proposals in the literature to improve the convergence of RJMCMCs. We also demonstrate the use of the same interpolation technique as a way to construct efficient 'global' proposal distributions for single-model MCMCs without prior knowledge of the structure of the posterior distribution, and discuss improvements that permit the method to be used in higher dimensional spaces efficiently.

  1. TALE proteins bind to both active and inactive chromatin.

    Science.gov (United States)

    Scott, James N F; Kupinski, Adam P; Kirkham, Christopher M; Tuma, Roman; Boyes, Joan

    2014-02-15

    TALE (transcription activator-like effector) proteins can be tailored to bind to any DNA sequence of choice and thus are of immense utility for genome editing and the specific delivery of transcription activators. However, to perform these functions, they need to occupy their sites in chromatin. In the present study, we have systematically assessed TALE binding to chromatin substrates and find that in vitro TALEs bind to their target site on nucleosomes at the more accessible entry/exit sites, but not at the nucleosome dyad. We show further that in vivo TALEs bind to transcriptionally repressed chromatin and that transcription increases binding by only 2-fold. These data therefore imply that TALEs are likely to bind to their target in vivo even at inactive loci.

  2. TALE-mediated modulation of transcriptional enhancers in vivo.

    Science.gov (United States)

    Crocker, Justin; Stern, David L

    2013-08-01

    We tested whether transcription activator-like effectors (TALEs) could mediate repression and activation of endogenous enhancers in the Drosophila genome. TALE repressors (TALERs) targeting each of the five even-skipped (eve) stripe enhancers generated repression specifically of the focal stripes. TALE activators (TALEAs) targeting the eve promoter or enhancers caused increased expression primarily in cells normally activated by the promoter or targeted enhancer, respectively. This effect supports the view that repression acts in a dominant fashion on transcriptional activators and that the activity state of an enhancer influences TALE binding or the ability of the VP16 domain to enhance transcription. In these assays, the Hairy repression domain did not exhibit previously described long-range transcriptional repression activity. The phenotypic effects of TALER and TALEA expression in larvae and adults are consistent with the observed modulations of eve expression. TALEs thus provide a novel tool for detection and functional modulation of transcriptional enhancers in their native genomic context.

  3. [Development of a Japanese version of the TALE scale].

    Science.gov (United States)

    Ochiai, Tsutomu; Oguchi, Takashi

    2013-12-01

    The Thinking About Life Experiences (TALE) Scale (Bluck & Alea, 2011) has three subscales that assess the self, social, and directive functions of autobiographical memory. This study constructs a Japanese version of the TALE Scale and examines its reliability and validity. Fifteen items that assess the three functions of autobiographical memory were translated into Japanese. We conducted an online investigation with 600 men and women between 20-59 years of age. In Study 1, exploratory and confirmatory factor analysis identified that the three-factor structure of the Japanese version of the TALE Scale was the same as the original TALE Scale. Sufficient internal consistency of the scale was found, and the construct validity of the scale was supported by correlation analysis. Study 2 confirmed that the test-retest reliabilities of the three subscales were sufficient. Thus, this Japanese version of the TALE Scale is useful to assess autobiographical memory functions in Japan.

  4. Elliptic Tales Curves, Counting, and Number Theory

    CERN Document Server

    Ash, Avner

    2012-01-01

    Elliptic Tales describes the latest developments in number theory by looking at one of the most exciting unsolved problems in contemporary mathematics--the Birch and Swinnerton-Dyer Conjecture. The Clay Mathematics Institute is offering a prize of 1 million to anyone who can discover a general solution to the problem. In this book, Avner Ash and Robert Gross guide readers through the mathematics they need to understand this captivating problem. The key to the conjecture lies in elliptic curves, which are cubic equations in two variables. These equations may appear simple, yet they arise from

  5. The Mechanics and Trajectory Control in Locust Jumping

    Institute of Scientific and Technical Information of China (English)

    Longbao Han; Zhouyi Wang; Aihong Ji; Zhendong Dai

    2013-01-01

    Locusts (Locusta migratoria manilensis) are characterised by their flying ability and abiding jump ability.Research on the jumping mechanics and behavior of locusts plays an important role in elucidating the mechanism of hexapod locomotion.The jump gestures of locusts were observed using high-speed video camera at 250 fps.The reaction forces of the hindlegs were measured using two three-dimensional sensors,in case the two hindlegs attached on separated sensor plates.The jump gestures and reaction forces were used to illustrate the locust jumping mechanism.Results show that the trajectory control is achieved by rapid rolling and yawing movements of the locust body,caused by the forelegs,midlegs and hindlegs in different jumping phases.The final jump trajectory was not determined until hind tarsi left platform.The horizontal co-impulse between two hindlegs might play a key role in jump stability and accuracy.Besides,the angle between two hindlegs affects the control of jump trajectory but has a little effect on the elevation angle of a jump,which is controlled mechanically by the initial position of the hindlegs.This research lays the groundwork for the probable design and development of biomimetic robotics.

  6. Theory of Clarissa Pinkola Estes and analyses of fairy tales – case study of the Red shoes

    OpenAIRE

    Kužnik, Branka

    2016-01-01

    The thesis Theory of Clarissa Pinkola Estes and analyses of fairy tales – case study of the Red shoes deals with fairy tales, analyses of contents and messages that every fairy tale has. Three fairy tales for children of the Danish fairy tale writer Hans Christian Andersen from the collection Fairy Tales (Ljubljana: Mladinska knjiga, 2005, translated from Danish by Silvana Orel Kos, illustrated by Marija Lucija Stupica) will be discussed. These fairy tales are: The Little Mermaid, The Steadfa...

  7. The Telescope Array's Low Energy Extension: TALE

    Science.gov (United States)

    Matthews, John

    2009-05-01

    A great deal of information about the sources of ultra high energy cosmic rays exists encoded in the energy spectrum. There are three spectral features in the ultra high energy regime (the second knee, the ankle, and the GZK cut-off). An important composition change also occurs in this energy range. The Telescope Array (TA) is a large area ultra high energy cosmic ray observatory built and operated by groups from the US, Japan, Korea, and Russia. The existing part of the Telescope Array already has good efficiency above the ankle (˜10^18.5 eV). These detectors are already in the field collecting data. The TA Low Energy Extension (TALE) refers to the detectors devoted to the ``low energy'' portion of the spectrum - 10^16.5 - 10^19 eV. The aim of TA/TALE is to understand the origin of cosmic rays and to study their composition over a broad energy range. We will introduce the detector components and discuss the opportunities.

  8. Genome Editing in Mice Using TALE Nucleases.

    Science.gov (United States)

    Wefers, Benedikt; Brandl, Christina; Ortiz, Oskar; Wurst, Wolfgang; Kühn, Ralf

    2016-01-01

    Gene engineering for generating targeted mouse mutants is a key technology for biomedical research. Using TALENs as sequence-specific nucleases to induce targeted double-strand breaks, the mouse genome can be directly modified in zygotes in a single step without the need for embryonic stem cells. By embryo microinjection of TALEN mRNAs and targeting vectors, knockout and knock-in alleles can be generated fast and efficiently. In this chapter we provide protocols for the application of TALENs in mouse zygotes.

  9. Promoting balance and jumping skills in children with Down syndrome.

    Science.gov (United States)

    Wang, Wai-Yi; Ju, Yun-Huei

    2002-04-01

    The purpose of this study was to investigate the changes in balance and qualitative and quantitative jumping performances by 20 children with Down syndrome (3 to 6 years) on jumping lessons. 30 typical children ages 3 to 6 years were recruited as a comparison group. Before the jumping lesson, a pretest was given subjects for balance and jumping skill measures based on the Motor Proficiency and Motor Skill Inventory, respectively. Subjects with Down syndrome received 3 sessions on jumping per week for 6 weeks but not the typical children. Then, a posttest was administered to all subjects. Analysis of covariance showed the pre- and posttest differences on scores for floor walk, beam walk, and horizontal and vertical jumping by subjects with Down syndrome were significantly greater than those for the typical children.

  10. Theoretical Modeling of Internal Hydraulic Jump in Density Currents

    CERN Document Server

    Firoozabadi, Bahar; Aryanfar, Asghar; Afshin, Hossein

    2013-01-01

    In this paper, we propose an analytical framework for internal hydraulic jumps. Density jumps or internal hydraulic jumps occur when a supper critical flow of water discharges into a stagnant layer of water with slightly different density. The approach used here is control volume method which is also used to analyze ordinary hydraulic jumps. The important difference here is that entrainment is taken into account. Using conservation equations with the aid of some simplifying assumptions we come to an equation that gives jump downstream height as function of jump upstream characteristics and the entrainment. To determine the magnitude of downstream height we use an experimental equation for calculating the entrainment. Finally we verify our framework by comparing the height that we gain from the derived equation with some experimental data.

  11. A-jump in horizontal inverted semicircular open channels

    Directory of Open Access Journals (Sweden)

    I.M.H. Rashwan

    2013-12-01

    Full Text Available The hydraulic jump is a transitional state from supercritical to subcritical flow. The phenomenon of the hydraulic jump has been widely studied because of its frequent occurrence in nature and because of its uses in many practical applications. In the present study the momentum principle is used to derive an equation expressed the hydraulic jump (A-jump occurred in a short horizontal reach of an inverted semicircular open channel. The derived equation indicates that the initial water depth and the tail water depth (conjugate depths are functions of the critical water depth. Various elements of the hydraulic jump are expressed in dimensionless case. The procedure of dimensionless ratios described in the present paper can be used to determine various elements of A-jump in an inverted semicircular channel when either the discharge and the relative initial depth (or tail water depth is known or the discharge and the relative dissipated energy are known.

  12. A Jump-Diffusion Model with Stochastic Volatility and Durations

    DEFF Research Database (Denmark)

    Wei, Wei; Pelletier, Denis

    Market microstructure theories suggest that the durations between transactions carry information about volatility. This paper puts forward a model featuring stochastic volatility, stochastic conditional duration, and jumps to analyze high frequency returns and durations. Durations affect price...... jumps in two ways: as exogenous sampling intervals, and through the interaction with volatility. We adopt a bivariate Ornstein-Ulenbeck process to model intraday volatility and conditional duration. We develop a MCMC algorithm for the inference on irregularly spaced multivariate processes with jumps....... The algorithm provides smoothed estimates of the latent variables such as spot volatility, conditional duration, jump times, and jump sizes. We apply this model to IBM data and find that volatility and conditional duration are interdependent. We also find that jumps play an important role in return variation...

  13. Robust Stabilization for Uncertain Linear Delay Markow Jump System

    Institute of Scientific and Technical Information of China (English)

    钟麦英; 汤兵勇; 黄小原

    2001-01-01

    Markov jump linear systems are defined as a family of linear systems with randomly Markov jumping parameters and are used to model systems subject to failures or changes in structure. The robust stabilization problem of jump linear delay system with umcerratnty was studied. By using of linear matrix inequalities, the existence conditions of robust stabilizing and the state feedback controller designing methods are also presented and proved. Finally, an illustrated example shows the effectiveness of this approach.

  14. Approximation of Jump Diffusions in Finance and Economics

    OpenAIRE

    Nicola Bruti-Liberati; Eckhard Platen

    2006-01-01

    In finance and economics the key dynamics are often specified via stochastic differential equations (SDEs) of jump-diffusion type. The class of jump-diffusion SDEs that admits explicit solutions is rather limited. Consequently, discrete time approximations are required. In this paper we give a survey of strong and weak numerical schemes for SDEs with jumps. Strong schemes provide pathwise approximations and therefore can be employed in scenario analysis, filtering or hedge simulation. Weak sc...

  15. Times and Sizes of Jumps in the Mexican Interest Rate

    OpenAIRE

    José Antonio Núñez Mora; Arturo Lorenzo Valdés

    2008-01-01

    This paper examines the role of jumps in a continuous-time short-term interest rate model for Mexico. A filtering algorithm provides estimates of jumps times and sizes in the time series of Mexican cetes for the 1998-2006 period. The empirical results indicate that the inclusion of jumps in the diffusion model represents a better alternative than not to include them.

  16. The Indecisive Feminist: Study of Anne Sexton's Revisionist Fairy Tales

    Directory of Open Access Journals (Sweden)

    Nadia Fayidh Mohammed

    2015-02-01

    Full Text Available Fairy tales to female writers are major resource for their abundant writings, but for the feminist poets since 1960s, they become essential subject matter to often deal with in their literary production. With the motivation to address the conventional tradition of patriarchal society, and re-address the stereotype females inhabiting these tales, feminist writers set upon revealing the underlying sub-context of these tales, presenting them with more adult-suited themes. Anne Sexton's Transformation is a pioneering revision of Grimm's fairy tales in which the poet does not only satirize the patriarchal society she grew up in, but she also rejects the female stereotype that her upbringing intended her to be. In the following paper, the feminist messages which Sexton's fairy tales intended to deliver are examined to reveal the poet's position concerning feminism and her relationship with female role-models and the male figures she presents in her fairy tales. Keywords: Anne Sexton, feminism, fairy tales, revisionism, postmodernist poetry, Transformations

  17. Quantitative analysis of TALE-DNA interactions suggests polarity effects.

    Science.gov (United States)

    Meckler, Joshua F; Bhakta, Mital S; Kim, Moon-Soo; Ovadia, Robert; Habrian, Chris H; Zykovich, Artem; Yu, Abigail; Lockwood, Sarah H; Morbitzer, Robert; Elsäesser, Janett; Lahaye, Thomas; Segal, David J; Baldwin, Enoch P

    2013-04-01

    Transcription activator-like effectors (TALEs) have revolutionized the field of genome engineering. We present here a systematic assessment of TALE DNA recognition, using quantitative electrophoretic mobility shift assays and reporter gene activation assays. Within TALE proteins, tandem 34-amino acid repeats recognize one base pair each and direct sequence-specific DNA binding through repeat variable di-residues (RVDs). We found that RVD choice can affect affinity by four orders of magnitude, with the relative RVD contribution in the order NG > HD ≈ NN > NI > NK. The NN repeat preferred the base G over A, whereas the NK repeat bound G with 10(3)-fold lower affinity. We compared AvrBs3, a naturally occurring TALE that recognizes its target using some atypical RVD-base combinations, with a designed TALE that precisely matches 'standard' RVDs with the target bases. This comparison revealed unexpected differences in sensitivity to substitutions of the invariant 5'-T. Another surprising observation was that base mismatches at the 5' end of the target site had more disruptive effects on affinity than those at the 3' end, particularly in designed TALEs. These results provide evidence that TALE-DNA recognition exhibits a hitherto un-described polarity effect, in which the N-terminal repeats contribute more to affinity than C-terminal ones.

  18. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos.

    Directory of Open Access Journals (Sweden)

    Simone Lemeer

    Full Text Available BACKGROUND: Protein-tyrosine kinases (PTKs regulate virtually all biological processes. PTKs phosphorylate substrates in a sequence-specific manner and relatively short peptide sequences determine selectivity. Here, we developed new technology to determine PTK activity profiles using peptide arrays. The zebrafish is an excellent model system to investigate signaling in the whole organism, given its wealth of genetic tools, including morpholino-mediated knock down technology. We used zebrafish embryo lysates to determine PTK activity profiles, thus providing the unique opportunity to directly compare the effect of protein knock downs on PTK activity profiles on the one hand and phenotypic changes on the other. METHODOLOGY: We used multiplex arrays of 144 distinct peptides, spotted on a porous substrate, allowing the sample to be pumped up and down, optimizing reaction kinetics. Kinase reactions were performed using complex zebrafish embryo lysates or purified kinases. Peptide phosphorylation was detected by fluorescent anti-phosphotyrosine antibody binding and the porous chips allowed semi-continuous recording of the signal. We used morpholinos to knock down protein expression in the zebrafish embryos and subsequently, we determined the effects on the PTK activity profiles. RESULTS AND CONCLUSION: Reproducible PTK activity profiles were derived from one-day-old zebrafiish embryos. Morpholino-mediated knock downs of the Src family kinases, Fyn and Yes, induced characteristic phenotypes and distinct changes in the PTK activity profiles. Interestingly, the peptide substrates that were less phosphorylated upon Fyn and Yes knock down were preferential substrates of purified Fyn and Yes. Previously, we demonstrated that Wnt11 knock down phenocopied Fyn/Yes knock down. Interestingly, Wnt11 knock down induced similar changes in the PTK activity profile as Fyn/Yes knock down. The control Nacre/Mitfa knock down did not affect the PTK activity profile

  19. Multiobjective Optimization Methodology A Jumping Gene Approach

    CERN Document Server

    Tang, KS

    2012-01-01

    Complex design problems are often governed by a number of performance merits. These markers gauge how good the design is going to be, but can conflict with the performance requirements that must be met. The challenge is reconciling these two requirements. This book introduces a newly developed jumping gene algorithm, designed to address the multi-functional objectives problem and supplies a viably adequate solution in speed. The text presents various multi-objective optimization techniques and provides the technical know-how for obtaining trade-off solutions between solution spread and converg

  20. Planar jumping-drop thermal diodes

    Science.gov (United States)

    Boreyko, Jonathan B.; Zhao, Yuejun; Chen, Chuan-Hua

    2011-12-01

    Phase-change thermal diodes rectify heat transport much more effectively than solid-state ones, but are limited by either the gravitational orientation or one-dimensional configuration. Here, we report a planar phase-change diode scalable to large areas with an orientation-independent diodicity of over 100, in which water/vapor is enclosed by parallel superhydrophobic and superhydrophilic plates. The thermal rectification is enabled by spontaneously jumping dropwise condensate which only occurs when the superhydrophobic surface is colder than the superhydrophilic surface.

  1. Understanding the physics of bungee jumping

    OpenAIRE

    Heck, A; Uylings, P.; Kędzierska, E.

    2010-01-01

    Changing mass phenomena like the motion of a falling chain, the behaviour of a falling elastic bar or spring, and the motion of a bungee jumper surprise many a physicist. In this article we discuss the first phase of bungee jumping, when the bungee jumper falls, but the bungee rope is still slack. In instructional material this phase is often considered a free fall, but when the mass of the bungee rope is taken into account, the bungee jumper reaches acceleration greater than g. This result i...

  2. Quantifying show jumping horse rider expertise using IMUs.

    Science.gov (United States)

    Patterson, M; Doyle, J; Cahill, E; Caulfield, B; McCarthy Persson, U

    2010-01-01

    Horse rider ability has long been measured using horse performance, competition results and visual observation. Scientific methods of measuring rider ability on the flat are emerging such as measuring position angles and harmony of the horse-rider system. To date no research has quantified rider ability in show jumping. Kinematic analysis and motion sensors have been used in sports other than show jumping to measure the quality of motor control patterns in humans. The aim of this study was to quantify rider ability in show jumping using body-mounted IMUs. Preliminary results indicate that there are clear differences in experienced and novice riders during show jumping.

  3. Distance perception in the spiny mouse Acomys cahirinus: vertical jumping.

    Science.gov (United States)

    Goldman, M; Skolnick, A J; Hernandez, T P; Tobach, E

    1992-12-01

    Acomys cahirinus, a precocial muroid, that has shown precise jumping in the natural habitat, did not jump from 25 cm in a laboratory situation. To investigate this further, A. cahirinus were observed jumping from platforms at two different heights, onto different sized checkered substrates and from a visual cliff. Adult animals discriminated between platforms that were 6.4 cm and 25.4 cm above the substrate and between small and large checkered patterns on the floor. Most adult animals and neonates jumped down on the shallow side of the visual cliff. Animals developed individual patterns of jumping over a series of trials, with some jumping often, some rarely, and others jumping only from the low platform. Good distance perception was indicated when they did not jump from heights, and by their making appropriate postural adjustment when they did jump from heights and landed without mishap. Different spacing of trials indicated that height was a more effective stimulus for animals which had all four conditions on the same day, while floor pattern was more effective for animals with each of the four conditions on a separate day.

  4. Long memory behavior of returns after intraday financial jumps

    Science.gov (United States)

    Behfar, Stefan Kambiz

    2016-11-01

    In this paper, characterization of intraday financial jumps and time dynamics of returns after jumps is investigated, and will be analytically and empirically shown that intraday jumps are power-law distributed with the exponent 1 finance, it is important to be able to distinguish between jumps and continuous sample path price movements, and this can be achieved by introducing a statistical test via calculating sums of products of returns over small period of time. In the case of having jump, the null hypothesis for normality test is rejected; this is based on the idea that returns are composed of mixture of normally-distributed and power-law distributed data (∼ 1 /r 1 + μ). Probability of rejection of null hypothesis is a function of μ, which is equal to one for 1 high returns after jumps are the effect; we show that returns caused by jump decay as power-law distribution. To test this idea empirically, we average over the time dynamics of all days; therefore the superposed time dynamics after jump represent a power-law, which indicates that there is a long memory with a power-law distribution of return after jump.

  5. Biomechanics research in ski jumping, 1991-2006.

    Science.gov (United States)

    Schwameder, Hermann

    2008-01-01

    In this paper, I review biomechanics research in ski jumping with a specific focus on publications presented between 1991 and 2006 on performance enhancement, limiting factors of the take-off, specific training and conditioning, aerodynamics, and safety. The first section presents a brief description of ski jumping phases (in-run, take-off, early flight, stable flight, and landing) regarding the biomechanical and functional fundamentals. The most important and frequently used biomechanical methods in ski jumping (kinematics, ground reaction force analyses, muscle activation patterns, aerodynamics) are summarized in the second section. The third section focuses on ski jumping articles and research findings published after the establishment of the V-technique in 1991, as the introduction of this technique has had a major influence on performance enhancement, ski jumping regulations, and the construction of hill profiles. The final section proposes topics for future research in the biomechanics of ski jumping, including: take-off and early flight and the relative roles of vertical velocity and forward somersaulting angular momentum; optimal jumping patterns utilizing the capabilities of individual athletes; development of kinematic and kinetic feedback systems for hill jumps; comparisons of simulated and hill jumps; effect of equipment modifications on performance and safety enhancement.

  6. Competitive Lotka-Volterra Population Dynamics with Jumps

    CERN Document Server

    Bao, Jianhai; Yin, Geroge; Yuan, Chenggui

    2011-01-01

    This paper considers competitive Lotka-Volterra population dynamics with jumps. The contributions of this paper are as follows. (a) We show stochastic differential equation (SDE) with jumps associated with the model has a unique global positive solution; (b) We discuss the uniform boundedness of $p$th moment with $p>0$ and reveal the sample Lyapunov exponents; (c) Using a variation-of-constants formula for a class of SDEs with jumps, we provide explicit solution for 1-dimensional competitive Lotka-Volterra population dynamics with jumps, and investigate the sample Lyapunov exponent for each component and the extinction of our $n$-dimensional model.

  7. pH jump induced α-helix folding.

    Directory of Open Access Journals (Sweden)

    Donten M. L.

    2013-03-01

    Full Text Available pH can be used to impact the folding equilibrium of peptides and proteins. This fact is utilized, similarly to temperature jumps, in pH jump experiments employing laser time-resolved spectroscopy to study the function and structural dynamics of these molecules. Here the application of pH jumps in folding experiments was investigated. Experiments with poly-L-glutamic acid alpha-helix formation shown the critical aspects of pH jump experiments and yielded direct information about the folding kinetics monitored with the amide I IR band.

  8. Effect of drop jump technique on the reactive strength index

    Directory of Open Access Journals (Sweden)

    Struzik Artur

    2016-09-01

    Full Text Available The basic drill of plyometric training aimed at improving lower limb power and jump height is a drop jump. This exercise can be performed using different techniques, which substantially affects jump variables. Therefore, the aim of this study was to compare the values of the reactive strength index (RSI for countermovement drop jumps (CDJs and bounce drop jumps (BDJs. The study was carried out in a group of 8 male youth basketball players. The tests were conducted using the AMTI BP600900 force plate to measure ground reaction forces and the Noraxon MyoMotion system to record kinematic data. Each player performed two CDJs and two BDJs from the height of 15, 30, 45 and 60 cm. The RSI was calculated as a ratio of jump height and contact time. Moreover, the RSI was determined for the amortization and take-off phases separately. Significant differences (p < 0.05 between RSI values for CDJs and BDJs were recorded for jumps from 30, 45 and 60 cm. Differences in RSI values for jumps from 15 cm were not significant. Furthermore, CDJ height values were significantly higher (p < 0.05 than the values recorded for BDJs. Times of contact, amortization and take-off during BDJs were significantly shorter (p < 0.05 than the respective values obtained for CDJs. Therefore, the use of the RSI to monitor plyometric training should be based on the drop jump technique that is commonly performed by basketball players.

  9. Development of a Minimally Actuated Jumping-Rolling Robot

    Directory of Open Access Journals (Sweden)

    Thanhtam Ho

    2015-04-01

    Full Text Available This paper presents development of a hybrid mobile robot in order to take advantage of both rolling and jumping locomotion on the ground. According to the unique design of the mechanism, the robot is able to execute both jumping and rolling skilfully by using only one DC motor. Changing the centre of gravity enables rolling of the robot and storage of energy is utilized for jumping. Mechanism design and control logic are validated by computer simulation. Simulation results show that the robot can jump nearly 1.3 times its diameter and roll at the speed of 3.3 times its diameter per second.

  10. Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases.

    Science.gov (United States)

    Shin, Jimann; Chen, Jiakun; Solnica-Krezel, Lilianna

    2014-10-01

    Custom-designed nucleases afford a powerful reverse genetic tool for direct gene disruption and genome modification in vivo. Among various applications of the nucleases, homologous recombination (HR)-mediated genome editing is particularly useful for inserting heterologous DNA fragments, such as GFP, into a specific genomic locus in a sequence-specific fashion. However, precise HR-mediated genome editing is still technically challenging in zebrafish. Here, we establish a GFP reporter system for measuring the frequency of HR events in live zebrafish embryos. By co-injecting a TALE nuclease and GFP reporter targeting constructs with homology arms of different size, we defined the length of homology arms that increases the recombination efficiency. In addition, we found that the configuration of the targeting construct can be a crucial parameter in determining the efficiency of HR-mediated genome engineering. Implementing these modifications improved the efficiency of zebrafish knock-in generation, with over 10% of the injected F0 animals transmitting gene-targeting events through their germline. We generated two HR-mediated insertion alleles of sox2 and gfap loci that express either superfolder GFP (sfGFP) or tandem dimeric Tomato (tdTomato) in a spatiotemporal pattern that mirrors the endogenous loci. This efficient strategy provides new opportunities not only to monitor expression of endogenous genes and proteins and follow specific cell types in vivo, but it also paves the way for other sophisticated genetic manipulations of the zebrafish genome.

  11. Tragicomedy and Pastoral in Shakespeare's The Winter's Tale

    OpenAIRE

    Heide, Sinem Kozanoglu

    2005-01-01

    This thesis, focusing on the diptych unity of Shakespeare s The Winter s Tale, examines the play from the perspective of pastoral tragicomedy. The Winter s Tale seems sharply divided into two halves; one for the most part tragic; the other principally comic; with Time standing in the middle as Chorus to announce their juncture and separation. Because of its very structure, The Winter s Tale was evaluated as two disjointed plays for centuries and condemned because of it, until its two parts an...

  12. Exploiting knowledge of jump-up and jump-down frequencies to determine the parameters of a Duffing oscillator

    Science.gov (United States)

    Ramlan, Roszaidi; Brennan, Michael J.; Kovacic, Ivana; Mace, Brian R.; Burrow, Stephen G.

    2016-08-01

    This work concerns the application of certain non-linear phenomena - jump frequencies in a base-excited Duffing oscillator - to the estimation of the parameters of the system. First, approximate analytical expressions are derived for the relationships between the jump-up and jump-down frequencies, the damping ratio and the cubic stiffness coefficient. Then, experimental results, together with the results of numerical simulations, are presented to show how knowledge of these frequencies can be exploited.

  13. Generation and initial characterization of FDD knock in mice.

    Directory of Open Access Journals (Sweden)

    Luca Giliberto

    Full Text Available BACKGROUND: Mutations in the integral membrane protein 2B, also known as BRI(2, a type II trans-membrane domain protein cause two autosomal dominant neurodegenerative diseases, Familial British and Danish Dementia. In these conditions, accumulation of a C-terminal peptide (ABri and ADan cleaved off from the mutated precursor protein by the pro-protein convertase furin, leads to amyloid deposition in the walls of blood vessels and parenchyma of the brain. Recent advances in the understanding of the generation of amyloid in Alzheimer's disease has lead to the finding that BRI(2 interacts with the Amyloid Precursor Protein (APP, decreasing the efficiency of APP processing to generate Abeta. The interaction between the two precursors, APP and BRI(2, and possibly between Abeta and ABri or ADan, could be important in influencing the rate of amyloid production or the tendency of these peptides to aggregate. METHODOLOGY/PRINCIPAL FINDINGS: We have generated the first BRI(2 Danish Knock-In (FDD(KI murine model of FDD, expressing the pathogenic decamer duplication in exon 6 of the BRI(2 gene. FDD(KI mice do not show any evident abnormal phenotype, with normal brain histology and no detectable amyloid deposition in blood vessel walls or parenchyma. CONCLUSIONS/SIGNIFICANCE: This new murine mouse model will be important to further understand the interaction between APP and BRI(2, and to provide insights into the molecular basis of FDD.

  14. A knock-in mouse model of congenital erythropoietic porphyria.

    Science.gov (United States)

    Ged, C; Mendez, M; Robert, E; Lalanne, M; Lamrissi-Garcia, I; Costet, P; Daniel, J Y; Dubus, P; Mazurier, F; Moreau-Gaudry, F; de Verneuil, H

    2006-01-01

    Congenital erythropoietic porphyria (CEP) is a recessive autosomal disorder characterized by a deficiency in uroporphyrinogen III synthase (UROS), the fourth enzyme of the heme biosynthetic pathway. The severity of the disease, the lack of specific treatment except for allogeneic bone marrow transplantation, and the knowledge of the molecular lesions are strong arguments for gene therapy. An animal model of CEP has been designed to evaluate the feasibility of retroviral gene transfer in hematopoietic stem cells. We have previously demonstrated that the knockout of the Uros gene is lethal in mice (Uros(del) model). This work describes the achievement of a knock-in model, which reproduces a mutation of the UROS gene responsible for a severe UROS deficiency in humans (P248Q missense mutant). Homozygous mice display erythrodontia, moderate photosensitivity, hepatosplenomegaly, and hemolytic anemia. Uroporphyrin (99% type I isomer) accumulates in urine. Total porphyrins are increased in erythrocytes and feces, while Uros enzymatic activity is below 1% of the normal level in the different tissues analyzed. These pathological findings closely mimic the CEP disease in humans and demonstrate that the Uros(mut248) mouse represents a suitable model of the human disease for pathophysiological, pharmaceutical, and therapeutic purposes.

  15. GENE KICKED MOUSE: KNOCK OUT MOUSE AND ITS APPLICATION

    Directory of Open Access Journals (Sweden)

    Rajashekar B

    2013-07-01

    Full Text Available A knockout mouse is a laboratory mouse in which genes are inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The 2007 Nobel Prize in physiology or medicine is awarded to Drs Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of principles for introducing specific gene modifications in mice by using embryonic stem cells. Progress to gene targeting using embryonic cell was developed by Evans and his co-workers. Ingenious development of gene targeting has been made by introducing recognition sites for the enzyme Cre recombinase, called loxP sites, into existing genes. When mice carrying such "floxed" genes are mated with transgenic mice expressing Cre recombinase, the target gene of the offspring is modified through Cre action. Gene targeting has transformed scientific medicine by permitting experimental testing of hypotheses regarding the function of specific genes. The first area to which experimental geneticists turned their attention after the birth of gene targeting in mammals was monogenic diseases. Gene targeting has been exceptionally useful in cancer research. A large number of protooncogenes, tumor suppressor genes, angiogenetic factors etc have been targeted in different tissues in mice to shed light on the induction and spreading of tumours. Gene-targeted mouse models have also become increasingly important in studies of host defense against pathogens. Gene targeted mice have become indispensable in virtually all aspects of medical research.

  16. Jump dynamics due to jump datum of compressible viscous Navier-Stokes flows in a bounded plane domain

    Science.gov (United States)

    Kweon, Jae Ryong

    2016-09-01

    In this paper, when the initial density has a jump across an interior curve in a bounded domain, we show unique existence, piecewise regularity and jump discontinuity dynamics for the density and the velocity vector governed by the Navier-Stokes equations of compressible viscous barotropic flows. A critical difficulty is in controlling the gradient of the pressure across the jump curve. This is resolved by constructing a vector function associated with the pressure jump value on the convecting curve and extending it to the whole domain.

  17. Understanding the physics of bungee jumping

    Science.gov (United States)

    Heck, André; Uylings, Peter; Kędzierska, Ewa

    2010-01-01

    Changing mass phenomena like the motion of a falling chain, the behaviour of a falling elastic bar or spring, and the motion of a bungee jumper surprise many a physicist. In this article we discuss the first phase of bungee jumping, when the bungee jumper falls, but the bungee rope is still slack. In instructional material this phase is often considered a free fall, but when the mass of the bungee rope is taken into account, the bungee jumper reaches acceleration greater than g. This result is contrary to the usual experience with free falling objects and therefore hard to believe for many a person, even an experienced physicist. It is often a starting point for heated discussions about the quality of the experiments and the physics knowledge of the experimentalist, or it may even prompt complaints about the quality of current physics education. But experiments do reveal the truth and students can do them supported by information and communication technology (ICT) tools. We report on a research project done by secondary school students and use their work to discuss how measurements with sensors, video analysis of self-recorded high-speed video clips and computer modelling allow study of the physics of bungee jumping.

  18. Jumping and Landing Techniques in Elite Women’s Volleyball

    Science.gov (United States)

    Tillman, Mark D.; Hass, Chris J.; Brunt, Denis; Bennett, Gregg R.

    2004-01-01

    Volleyball has become one of the most widely played participant sports in the world. Participation requires expertise in many physical skills and performance is often dependent on an individual’s ability to jump and land. The incidence of injury in volleyball is similar to the rates reported for sports that are considered more physical contact sports. Though the most common source of injury in volleyball is the jump landing sequence, little research exists regarding the prevalence of jumping and landing techniques. The purpose of this study was to quantify the number of jumps performed by female volleyball players in competitive matches and to determine the relative frequency of different jump-landing techniques. Videotape recordings of two matches among four volleyball teams were analyzed for this study. Each activity was categorized by jump type (offensive spike or defensive block) and phase (jump or landing). Phase was subcategorized by foot use patterns (right, left, or both). Each of the players averaged nearly 22 jump-landings per game. Foot use patterns occurred in unequal amounts (p < 0.001) with over 50% of defensive landings occurring on one foot. Coaches, physical educators, and recreation providers may utilize the findings of this inquiry to help prevent injuries in volleyball. Key Points The incidence of injury in volleyball is nearly equivalent to injury rates reported for ice hockey and soccer. Most injuries in volleyball occur during the jump landing sequence, but few data exist regarding jump landing techniques for elite female players. Our data indicate that the vast majority of jumps utilize two feet, but approximately half of landings occur with only one foot. Coaches, physical educators, and recreation providers may utilize the findings of this inquiry to prevent possible injuries in athletes, students, or those who participate in volleyball for recreational purposes. PMID:24497818

  19. Neuromuscular function during drop jumps in young and elderly males.

    Science.gov (United States)

    Piirainen, Jarmo M; Linnamo, Vesa; Sippola, Niina; Avela, Janne

    2012-12-01

    The Hoffman reflex (H-reflex), indicating alpha-motoneuron pool activity, has been shown to be task - and in resting conditions - age dependent. How aging affects H-reflex activity during explosive movements is not clear at present. The purpose of this study was to examine the effects of aging on H-reflexes during drop jumps, and its possible role in drop jump performance. Ten young (26.8 ± 2.7 years) and twenty elderly (64.2 ± 2.7 years) subjects participated in the study. Maximal drop jump performance and soleus H-reflex response (H/M jump) 20 ms after ground contact were measured in a sledge ergometer. Maximal H-reflex, maximal M-wave, Hmax/Mmax-ratio and H-reflex excitability curves were measured during standing rest. Although in young the H-reflex response (Hmax/Mmax) was 6.5% higher during relaxed standing and 19.7% higher during drop jumps (H jump/M jump) than in the elderly group, these differences were not statistically significant. In drop jumps, the elderly subjects had lower jumping height (30.4%, p push-off force (18.0%, p push-off time (31.0% p push-off force (r = 0.833, p push-off time (r = -0.857, p strategies in drop jumps. However, it does not fully explain age related differences in jumping performance, since age related differences in H-reflex activity were non-significant. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Study of Knocking Effect in Compression Ignition Engine with Hydrogen as a Secondary Fuel

    Directory of Open Access Journals (Sweden)

    R. Sivabalakrishnan

    2014-01-01

    Full Text Available The aim of this project is detecting knock during combustion of biodiesel-hydrogen fuel and also the knock is suppressed by timed injection of diethyl ether (DEE with biodiesel-hydrogen fuel for different loads. Hydrogen fuel is an effective alternate fuel in making a pollution-free environment with higher efficiency. The usage of hydrogen in compression ignition engine leads to production of knocking or detonation because of its lower ignition energy, wider flammability range, and shorter quenching distance. Knocking combustion causes major engine damage, and also reduces the efficiency. The method uses the measurement and analysis of cylinder pressure signal for various loads. The pressure signal is to be converted into frequency domain that shows the accurate knocking combustion of fuel mixtures. The variation of pressure signal is gradually increased and smoothly reduced to minimum during normal combustion. The rapid rise of pressure signal has occurred during knocking combustion. The experimental setup was mainly available for evaluating the feasibility of normal combustion by comparing with the signals from both fuel mixtures in compression ignition engine. This method provides better results in predicting the knocking feature of biodiesel-hydrogen fuel and the usage of DEE provides complete combustion of fuels with higher performance, and lower emission.

  1. Knock detection system to improve petrol engine performance, using microphone sensor

    Science.gov (United States)

    Sujono, Agus; Santoso, Budi; Juwana, Wibawa Endra

    2017-01-01

    An increase of power and efficiency of spark ignition engines (petrol engines) are always faced with the problem of knock. Even the characteristics of the engine itself are always determined from the occurrence of knock. Until today, this knocking problem has not been solved completely. Knock is caused by principal factors that are influenced by the engine rotation, the load or opening the throttle and spark advance (ignition timing). In this research, the engine is mounted on the engine test bed (ETB) which is equipped with the necessary sensors. Knock detection using a new method, which is based on pattern recognition, which through the knock sound detection by using a microphone sensor, active filter, the regression of the normalized envelope function, and the calculation of the Euclidean distance is used for identifying knock. This system is implemented with a microcontroller which uses fuzzy logic controller ignition (FLIC), which aims to set proper spark advance, in accordance with operating conditions. This system can improve the engine performance for approximately 15%.

  2. Once upon Anion: A Tale of Photodetachment

    Science.gov (United States)

    Lineberger, W. Carl

    2013-04-01

    This contribution is very much a personal history of a journey through the wonderful world of anion chemistry, and a tale of how advances in laser technologies, theoretical methods, and computational capabilities continuously enabled advances in our understanding. It is a story of the excitement and joy that come from the opportunity to add to the fabric of science, and to do so by working as a group of excited explorers with common goals. The participants in this journey include me, my students and postdoctoral associates, my collaborators, and our many generous colleagues. It all happened, in the words of the Beatles, “with a little help from my friends.” Actually, it was so much more than a little help!

  3. REVIEW: TALES OF KHA BA DKAR PO

    Directory of Open Access Journals (Sweden)

    Jundan (Jasmine Zhang

    2015-03-01

    Full Text Available Review of: Jing Guo . 2012. Xue shan zhi shu [Tales of Kha ba dkar po] [ཁ་བ་དཀར་པོ]. Kunming: Yunnan People's Press. My favorite color is to add a little white on the whiteness, as if there was a snow-white eagle landing on a snow-covered mountain rock. My favorite color is to add a bit green on the greenness, as if there was an emerald parrot flying in the wild walnut woods. Deqin xianzi lyrics. These lyrics evoke a space beyond a sense of realism. In his book, Tales of Kha ba dkar po (ToK, Guo mentions these lines three times, suggesting a transcendental experience one may encounter in Tibetan areas while, at the same time, humbled by the mindset of human nature relations enacted by Tibetan people. ToK is, in many ways, a valuable academic work. Guo's favorite lines of xianzi allude to a 'space-in-between' the secular and sacred, which provides a unique experience for a broad readership, and induces the readers to deeper reflections on topics such as 'nature/ culture', 'belief', 'rite', and 'life/ death'. ToK is one of nineteen contemporary anthropological and ethnological works conducted in Yunnan Province, Southwest China and published in the 'Anthropology and Ethnology series in Contemporary China'. In the preface for the series, Yin (2012 suggests that there are two primary reasons for the somewhat slow development of Chinese scholarship in the field of anthropology and ethnology. One is the historically Han-centered intellectual atmosphere, and the other is the ideological ambivalence that ethnic culture has faced since the establishment of the People's Republic of China. In this context, Guo's longitudinal academic and intellectual engagement with the Tibetan communities in northwest Yunnan is included in this series as part of the increasing recognition of the significance of understanding southwest China's complex ethnic and cultural diversity.

  4. THE TEXT OF CAXTON'S SECOND EDITION OF THE CANTERBURY TALES

    Directory of Open Access Journals (Sweden)

    Bordalejo Bárbara

    2005-12-01

    Full Text Available This article describes recent research on the textual relationship between the first and second editions of the Canterbury Tales printed in England by William Caxton and it also explores the textual affiliations of the manuscript source for the corrections in the second edition. Using both computerised and manual methods the variant readings between the first and second editions of the Tales are isolated. Examples of the textual affiliations of the manuscript source of Caxton's second edition are analysed. This article concludes that the manuscript source for the corrections introduced in Caxton's second edition of the Tales was of the same quality as tlie best extant manuscripts and that its readings can help our understanding of the textual tradition and can clarify the text for editors of the Tales.

  5. Circle of Life——Symbolism in The Winter's Tale

    Institute of Scientific and Technical Information of China (English)

    李潇雨

    2007-01-01

    This essay tries to illustrate Winter's Tale's symbolic meaning about human life.It draws conclusion that Shakespeare's plan is to combine the natural rule of seasonal cycle with the life circle of human world.

  6. Resurrecting the buried self: fairy tales and the analytic encounter.

    Science.gov (United States)

    Jacobs, Linda

    2011-12-01

    The author uses the lens of myth and fairy tales to examine the narratives generated by the analytic experience. Fairy tales are understood as representing fundamental developmental conflicts, accounting for their enduring power over time. The analytic encounter is seen as an analogue of the fairy tale in which the hidden self, damaged by loss and abandonment, reemerges only through the redemptive power of [an] other's love. Clinical material is presented in which hidden parts of the patient's self are projected into the analyst for safekeeping; these hidden parts resonate with the analyst's own lost, unrealized potential and form an intersubjective experience which the author believes is transformative. The patient's dormant powers emerge in a newly experienced atmosphere of recognition, and in this way, the analytic encounter resembles the fairy tale in providing an identificatory bond and a protective space for the patient's hidden vitality.

  7. The Neutralization of Tropes in Armenian Fairy Tale Narratives

    Directory of Open Access Journals (Sweden)

    Alvard Jivanyan

    2007-01-01

    Full Text Available An important stylistic feature of the fairy tale is its tendency toneutralize tropes by animating them. Distinctive fairy tale devices, transformations, for instance, appear at the expense of the intentional enlivening of the worn semantics of some hackneyed tropes. Neutralized tropes should be interpreted literally. In case of alternative, i.e. metaphoric interpretation, the succeeding narrative stretch will be under threat of logical and semantic collapse. A very similar phenomenon was observed by Zvetan Todorov in the fantastic fiction. As a rule, the oral fairy tale does not show the rhetorical figure and its extension in the same textual cut. The hackneyed trope is mostly absent. It is true; it can be easily restored owing to the fact that it is a phrase the listeners/readers are well aware of. Doubtless, we are far from claiming that any transformation in a fairy tale appears as a consequence of a rhetorical operation.

  8. [Transcription activator-like effectors(TALEs)based genome engineering].

    Science.gov (United States)

    Zhao, Mei-Wei; Duan, Cheng-Li; Liu, Jiang

    2013-10-01

    Systematic reverse-engineering of functional genome architecture requires precise modifications of gene sequences and transcription levels. The development and application of transcription activator-like effectors(TALEs) has created a wealth of genome engineering possibilities. TALEs are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas species. The DNA-binding domain of each TALE typically consists of tandem 34-amino acid repeat modules rearranged according to a simple cipher to target new DNA sequences. Customized TALEs can be used for a wide variety of genome engineering applications, including transcriptional modulation and genome editing. Such "genome engineering" has now been established in human cells and a number of model organisms, thus opening the door to better understanding gene function in model organisms, improving traits in crop plants and treating human genetic disorders.

  9. Expression analysis of TALE family transcription factors during avian development.

    Science.gov (United States)

    Coy, Sarah E; Borycki, Anne-Gaëlle

    2010-04-01

    The TALE family of homeodomain containing transcription factors consists of the Meis, Prep and Tgif, and the Pbx subfamily of proteins. Several TALE orthologues have been identified in amniotes, but no comprehensive analysis of their expression pattern during embryogenesis has been performed. Here, we report on TALE gene expression in the avian embryo. During embryonic development, Pbx genes are predominantly expressed in the neural ectoderm and paraxial mesoderm, although Pbx3 is restricted to the intermediate and lateral mesoderm, and anterior central nervous system. Members of the Meis, Prep, and Tgif subfamilies are expressed at high levels in the paraxial mesoderm, and display differential expression along the anterior-posterior and dorsoventral axes of the developing neural tube. Overall the expression patterns reported in this study are consistent with the known function of the TALE gene family in controlling early patterning of limb, neural tube and paraxial mesoderm tissues during embryogenesis.

  10. A TALE nuclease architecture for efficient genome editing.

    Science.gov (United States)

    Miller, Jeffrey C; Tan, Siyuan; Qiao, Guijuan; Barlow, Kyle A; Wang, Jianbin; Xia, Danny F; Meng, Xiangdong; Paschon, David E; Leung, Elo; Hinkley, Sarah J; Dulay, Gladys P; Hua, Kevin L; Ankoudinova, Irina; Cost, Gregory J; Urnov, Fyodor D; Zhang, H Steve; Holmes, Michael C; Zhang, Lei; Gregory, Philip D; Rebar, Edward J

    2011-02-01

    Nucleases that cleave unique genomic sequences in living cells can be used for targeted gene editing and mutagenesis. Here we develop a strategy for generating such reagents based on transcription activator-like effector (TALE) proteins from Xanthomonas. We identify TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and use these nucleases to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%. We further show that designed TALEs can regulate endogenous mammalian genes. These studies demonstrate the effective application of designed TALE transcription factors and nucleases for the targeted regulation and modification of endogenous genes.

  11. Modeling financial contagion using mutually exciting jump processes

    NARCIS (Netherlands)

    Aït-Sahalia, Y.; Cacho-Diaz, J.; Laeven, R.J.A.

    2013-01-01

    We propose a model designed to capture the dynamics of asset returns, with periods of crises that are characterized by contagion. In the model, a jump in one region of the world increases the intensity of jumps both in the same region (self-excitation) as well as in other regions (mutual

  12. Modeling financial contagion using mutually exciting jump processes

    NARCIS (Netherlands)

    Aït-Sahalia, Y.; Cacho-Diaz, J.; Laeven, R.J.A.

    2015-01-01

    We propose a model to capture the dynamics of asset returns, with periods of crises that are characterized by contagion. In the model, a jump in one region of the world increases the intensity of jumps both in the same region (self-excitation) as well as in other regions (cross-excitation),

  13. How Can We Tell if Frogs Jump Further?

    Science.gov (United States)

    Drummond, Gordon B.; Tom, Brian D. M.

    2011-01-01

    How effective is training frogs to jump? This is perhaps the most frequent question in biology that is subjected to statistical analysis: does a treatment make a difference? One can examine whether there is indeed a training effect, by first assuming the opposite. That is, the authors assume that training has no effect on the mean distance jumped.…

  14. Teaching Jump Rope to Children with Visual Impairments

    Science.gov (United States)

    Lieberman, Lauren J.; Schedlin, Haley; Pierce, Tristan

    2009-01-01

    This article presents strategies for jumping rope for children with visual impairments. Giving choices related to the types of rope and the use of mats is important. In addition, using appropriate instructional strategies and modifications will make jumping rope a skill that the children will enjoy and will lead to their involvement in other…

  15. Jump Tails, Extreme Dependencies, and the Distribution of Stock Returns

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Todorov, Viktor

    We provide a new framework for estimating the systematic and idiosyncratic jump tail risks in financial asset prices. The theory underlying our estimates are based on in-fill asymptotic arguments for directly identifying the systematic and idiosyncratic jumps, together with conventional long...

  16. The Triple Jump: Assessing Problem Solving in Psychiatry.

    Science.gov (United States)

    O'Gorman, Ethna C.; Trimble, Peter; Smyth, Joe

    1998-01-01

    Describes an attempt to assess a final-year course in psychiatry using the Triple Jump. In this course, students on placement in psychiatric units perfect psychiatry skills that were acquired during the previous year by direct contact with patients. The Triple Jump is used to assess problem-solving skills in management strategy on cases. (PVD)

  17. Feller Property for a Special Hybrid Jump-Diffusion Model

    Directory of Open Access Journals (Sweden)

    Jinying Tong

    2014-01-01

    Full Text Available We consider the stochastic stability for a hybrid jump-diffusion model, where the switching here is a phase semi-Markovian process. We first transform the process into a corresponding jump-diffusion with Markovian switching by the supplementary variable technique. Then we prove the Feller and strong Feller properties of the model under some assumptions.

  18. A time inhomogeneous Cox-Ingersoll-Ross diffusion with jumps

    CERN Document Server

    Hoepfner, Reinhard

    2009-01-01

    We consider a time inhomogeneous Cox-Ingersoll-Ross diffusion with positive jumps. We exploit a branching property to prove existence of a unique strong solution under a restrictive condition on the jump measure. We give Laplace transforms for the transition probabilities, with an interpretation in terms of limits of mixtures over Gamma laws.

  19. How Can We Tell if Frogs Jump Further?

    Science.gov (United States)

    Drummond, Gordon B.; Tom, Brian D. M.

    2011-01-01

    How effective is training frogs to jump? This is perhaps the most frequent question in biology that is subjected to statistical analysis: does a treatment make a difference? One can examine whether there is indeed a training effect, by first assuming the opposite. That is, the authors assume that training has no effect on the mean distance jumped.…

  20. Tuning Superhydrophobic Nanostructures to Enhance Jumping-Droplet Condensation

    Science.gov (United States)

    Mulroe, Megan; Srijanto, Bernadeta; Collier, Patrick; Boreyko, Jonathan

    2016-11-01

    It was recently discovered that condensation growing on a nanostructured superhydrophobic surface can spontaneously jump off the surface when two or more droplets coalesce together. The minimum droplet size for jumping to occur is of order 10 microns, but it is unclear whether this is the true lower limit of jumping droplets or simply a limitation of current superhydrophobic surfaces. Here, we analyze the dynamics of jumping droplets on six different superhydrophobic surfaces where the topography of the nanopillars was systematically varied. The critical diameter for jumping to occur was observed to be highly dependent upon the height and diameter of the nanopillars; surfaces with very tall and slender nanopillars enabled jumping droplets at a smaller critical size of order 1 micron. An energetic model of the incipient growth of condensate shows that the nanostructure topology affects the rate of increase of a growing droplet's apparent contact angle, with jumping being enabled at very large angles. These findings indicate that the true upper limit to the performance of jumping-droplet condensers has not yet been reached and can be further improved using advanced nanofabrication techniques.

  1. Empirical likelihood inference for diffusion processes with jumps

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper, we consider the empirical likelihood inference for the jump-diffusion model. We construct the confidence intervals based on the empirical likelihood for the infinitesimal moments in the jump-diffusion models. They are better than the confidence intervals which are based on the asymptotic normality of point estimates.

  2. A Safe and Effective Modification of Thomson's Jumping Ring Experiment

    Science.gov (United States)

    Waschke, Felix; Strunz, Andreas; Meyn, Jan-Peter

    2012-01-01

    The electrical circuit of the jumping ring experiment based on discharging a capacitor is optimized. The setup is scoop proof at 46 V and yet the ring jumps more than 9 m high. The setup is suitable for both lectures and student laboratory work in higher education. (Contains 1 table, 8 figures and 3 footnotes.)

  3. Could the deep squat jump predict weightlifting performance?

    Science.gov (United States)

    Vizcaya, Francisco J; Viana, Oscar; del Olmo, Miguel Fernandez; Acero, Rafael Martin

    2009-05-01

    This research was carried out with the aim of describing the deep squat jump (DSJ) and comparing it with the squat (SJ) and countermovement (CMJ) jumps, to introduce it as a strength testing tool in the monitoring and control of training in strength and power sports. Forty-eight male subjects (21 weightlifters, 12 triathletes, and 15 physical education students) performed 3 trials of DSJ, SJ, and CMJ with a 1-minute rest among them. For the weightlifters, snatch and clean and jerk results during the Spanish Championship 2004 and the 35th EU Championships 2007 were collected to study the relationship among vertical jumps and weightlifters' performance. A 1-way analysis of variance (ANOVA) showed significant differences between groups in the vertical jumps, with the highest jumps for the weightlifters and the lowest for the triathletes. An ANOVA for repeated measures (type of jump) showed better results for DSJ and CMJ than SJ in all groups. A linear regression analysis was performed to determine the association between weightlifting and vertical jump performances. Correlations among the weightlifting performance and the vertical jumps were also calculated and determined using Pearson r. Results have shown that both CMJ and DSJ are strongly correlated with weightlifting ability. Therefore, both measures can be useful for coaches as a strength testing tool in the monitoring and control of training in weightlifting.

  4. Evaluation of Metabolic Stress between Jumping at Different Cadences on the Digi-Jump Machine.

    Science.gov (United States)

    Lyons, Thomas S; Navalta, James W; Callahan, Zachary J

    The American College of Sports Medicine (ACSM) recommends that healthy adults achieve a minimum of thirty minutes of moderate intensity aerobic exercise five days per week. While cycling, walking, and jogging are commonly observed methods of achieving these recommendations, another option may be repetitive jumping. The purpose of this study was to examine the metabolic responses between repetitive jumping at a cadence of 120 jumps per minute (JPMs) vs. 100 JPMs when utilizing the Digi-Jump machine. Twenty-eight subjects completed two jumping trials, one at 120 JPMs and one at 100 JPMs. Subjects jumped until volitional exhaustion, or for a maximum of fifteen minutes. Oxygen uptake (VO2), heart rate (HR), respiratory exchange ratio (RER), and rating of perceived exertion (RPE) were assessed each minute of each exercise trial. RPE was differentiated, in that subjects reported perceived exertion of their total body, their upper-leg, and their lower leg. Results of this study indicated that there was no significant difference between the two trials for VO2, HR, or total body RPE. Differences were reported between trials for peak and average RER, with the 120 JPM trial eliciting a lower RER for both (peak: 1.08 ± .087 vs. 1.17 ± .1 p=.000; average: .99 ± .076 vs. 1.04 ± .098 p=.002), peak upper leg RPE (120: 15.29 ± 3.89 vs. 100: 16.75 ± 2.52 p=.022), and average lower leg RPE (120: 15.04 ± 2.55 vs. 100: 13.94 ± 2.02 p=.019). Also, there was a significant difference in exercise duration between the trials, with subjects able to exercise longer during the 120 JPM trial (12.4 ± 3.42 mins vs. 9.68 ± 4.31 mins p=.000). These data indicate that while the physiological stress may not be different between the two trials as indicated by VO2 and HR, the 120 JPM trial appears less strenuous as evidenced by RER values and by subjects' ability to exercise longer at that cadence.

  5. Edition for fairy tale therapy: to educators, teachers, psychologists, parents

    Directory of Open Access Journals (Sweden)

    Тарас Вікторович Полковенко

    2016-06-01

    Full Text Available The article is sanctified to one of new and interesting method of children’s education – fairy tale therapy, which can also provide the therapeutic effect, in particular, for the decline of level of anxiety, overcoming of some phobias, and also at treatment of separate psychosomatic disorders. Publishers should pay attention to the preparation and publication of fairy tales for a wider implementation of this method

  6. The hydraulic jump and ripples in liquid helium

    Energy Technology Data Exchange (ETDEWEB)

    Rolley, E. [Laboratoire de Physique Statistique de l' ENS, associe au CNRS et aux Universites Paris 6 et Paris 7, 24 rue Lhomond, 75005 Paris (France)]. E-mail: rolley@lps.ens.fr; Guthmann, C. [Laboratoire de Physique Statistique de l' ENS, associe au CNRS et aux Universites Paris 6 et Paris 7, 24 rue Lhomond, 75005 Paris (France); Pettersen, M.S. [Washington and Jefferson College, 60 S. Lincoln St., Washington, PA 15301 (United States)

    2007-05-01

    We have studied the characteristics of the circular hydraulic jump using liquid helium. Surprisingly, the radius of the jump does not change at the superfluid transition. We think that the flow is still dissipative below the lambda point because the velocity exceeds the critical one. The jump radius R{sub j} is compared with various models. In our parameter range, we find that the jump can be treated as a shock, and that capillary effects are important. Below the superfluid transition, we observed a standing capillary wave between the impact of the jet and the jump. Assuming that the superfluid flow can be described with an effective viscosity, we calculate the wave vector and thus obtain the value of the liquid thickness, which is in reasonable agreement with predictions. However, the spatial variation of the wave amplitude depends much more strongly on temperature than we calculate.

  7. Effects of isometric scaling on vertical jumping performance.

    Directory of Open Access Journals (Sweden)

    Maarten F Bobbert

    Full Text Available Jump height, defined as vertical displacement in the airborne phase, depends on vertical takeoff velocity. For centuries, researchers have speculated on how jump height is affected by body size and many have adhered to what has come to be known as Borelli's law, which states that jump height does not depend on body size per se. The underlying assumption is that the amount of work produced per kg body mass during the push-off is independent of size. However, if a big body is isometrically downscaled to a small body, the latter requires higher joint angular velocities to achieve a given takeoff velocity and work production will be more impaired by the force-velocity relationship of muscle. In the present study, the effects of pure isometric scaling on vertical jumping performance were investigated using a biologically realistic model of the human musculoskeletal system. The input of the model, muscle stimulation over time, was optimized using jump height as criterion. It was found that when the human model was miniaturized to the size of a mouse lemur, with a mass of about one-thousandth that of a human, jump height dropped from 40 cm to only 6 cm, mainly because of the force-velocity relationship. In reality, mouse lemurs achieve jump heights of about 33 cm. By implication, the unfavourable effects of the small body size of mouse lemurs on jumping performance must be counteracted by favourable effects of morphological and physiological adaptations. The same holds true for other small jumping animals. The simulations for the first time expose and explain the sheer magnitude of the isolated effects of isometric downscaling on jumping performance, to be counteracted by morphological and physiological adaptations.

  8. Effects of isometric scaling on vertical jumping performance.

    Science.gov (United States)

    Bobbert, Maarten F

    2013-01-01

    Jump height, defined as vertical displacement in the airborne phase, depends on vertical takeoff velocity. For centuries, researchers have speculated on how jump height is affected by body size and many have adhered to what has come to be known as Borelli's law, which states that jump height does not depend on body size per se. The underlying assumption is that the amount of work produced per kg body mass during the push-off is independent of size. However, if a big body is isometrically downscaled to a small body, the latter requires higher joint angular velocities to achieve a given takeoff velocity and work production will be more impaired by the force-velocity relationship of muscle. In the present study, the effects of pure isometric scaling on vertical jumping performance were investigated using a biologically realistic model of the human musculoskeletal system. The input of the model, muscle stimulation over time, was optimized using jump height as criterion. It was found that when the human model was miniaturized to the size of a mouse lemur, with a mass of about one-thousandth that of a human, jump height dropped from 40 cm to only 6 cm, mainly because of the force-velocity relationship. In reality, mouse lemurs achieve jump heights of about 33 cm. By implication, the unfavourable effects of the small body size of mouse lemurs on jumping performance must be counteracted by favourable effects of morphological and physiological adaptations. The same holds true for other small jumping animals. The simulations for the first time expose and explain the sheer magnitude of the isolated effects of isometric downscaling on jumping performance, to be counteracted by morphological and physiological adaptations.

  9. Dynamics and stability of directional jumps in the desert locust

    Science.gov (United States)

    Gvirsman, Omer

    2016-01-01

    Locusts are known for their ability to jump large distances to avoid predation. The jump also serves to launch the adult locust into the air in order to initiate flight. Various aspects of this important behavior have been studied extensively, from muscle physiology and biomechanics, to the energy storage systems involved in powering the jump, and more. Less well understood are the mechanisms participating in control of the jump trajectory. Here we utilise video monitoring and careful analysis of experimental directional jumps by adult desert locusts, together with dynamic computer simulation, in order to understand how the locusts control the direction and elevation of the jump, the residual angular velocities resulting from the jump and the timing of flapping-flight initiation. Our study confirms and expands early findings regarding the instrumental role of the initial body position and orientation. Both real-jump video analysis and simulations based on our expanded dynamical model demonstrate that the initial body coordinates of position (relative to the hind-legs ground-contact points) are dominant in predicting the jumps’ azimuth and elevation angles. We also report a strong linear correlation between the jumps’ pitch-angular-velocity and flight initiation timing, such that head downwards rotations lead to earlier wing opening. In addition to offering important insights into the bio-mechanical principles of locust jumping and flight initiation, the findings from this study will be used in designing future prototypes of a bio-inspired miniature jumping robot that will be employed in animal behaviour studies and environmental monitoring applications. PMID:27703846

  10. Dynamics and stability of directional jumps in the desert locust

    Directory of Open Access Journals (Sweden)

    Omer Gvirsman

    2016-09-01

    Full Text Available Locusts are known for their ability to jump large distances to avoid predation. The jump also serves to launch the adult locust into the air in order to initiate flight. Various aspects of this important behavior have been studied extensively, from muscle physiology and biomechanics, to the energy storage systems involved in powering the jump, and more. Less well understood are the mechanisms participating in control of the jump trajectory. Here we utilise video monitoring and careful analysis of experimental directional jumps by adult desert locusts, together with dynamic computer simulation, in order to understand how the locusts control the direction and elevation of the jump, the residual angular velocities resulting from the jump and the timing of flapping-flight initiation. Our study confirms and expands early findings regarding the instrumental role of the initial body position and orientation. Both real-jump video analysis and simulations based on our expanded dynamical model demonstrate that the initial body coordinates of position (relative to the hind-legs ground-contact points are dominant in predicting the jumps’ azimuth and elevation angles. We also report a strong linear correlation between the jumps’ pitch-angular-velocity and flight initiation timing, such that head downwards rotations lead to earlier wing opening. In addition to offering important insights into the bio-mechanical principles of locust jumping and flight initiation, the findings from this study will be used in designing future prototypes of a bio-inspired miniature jumping robot that will be employed in animal behaviour studies and environmental monitoring applications.

  11. Jumping Jupiter can explain Mercury's orbit

    CERN Document Server

    Roig, Fernando; DeSouza, Sandro Ricardo

    2016-01-01

    The orbit of Mercury has large values of eccentricity and inclination that cannot be easily explained if this planet formed on a circular and coplanar orbit. Here, we study the evolution of Mercury's orbit during the instability related to the migration of the giant planets in the framework of the jumping Jupiter model. We found that some instability models are able to produce the correct values of Mercury's eccentricity and inclination, provided that relativistic effects are included in the precession of Mercury's perihelion. The orbital excitation is driven by the fast change of the normal oscillation modes of the system corresponding to the perihelion precession of Jupiter (for the eccentricity), and the nodal regression of Uranus (for the inclination).

  12. The Voter Model and Jump Diffusion

    CERN Document Server

    Majmudar, Jimit; Baumgaertner, Bert O; Tyson, Rebecca C

    2015-01-01

    Opinions, and subsequently opinion dynamics, depend not just on interactions among individuals, but also on external influences such as the mass media. The dependence on local interactions, however, has received considerably more attention. In this paper, we use the classical voter model as a basis, and extend it to include external influences. We show that this new model can be understood using the theory of jump diffusion processes. We derive results pertaining to fixation probability and expected consensus time of the process, and find that the contribution of an external influence significantly dwarfs the contribution of the node-to-node interactions in terms of driving the social network to eventual consensus. This result suggests the potential importance of ``macro-level'' phenomena such as the media influence as compared to the ``micro-level'' local interactions, in modelling opinion dynamics.

  13. CAPTURE OF TROJANS BY JUMPING JUPITER

    Energy Technology Data Exchange (ETDEWEB)

    Nesvorny, David [Department of Space Studies, Southwest Research Institute, 1050 Walnut St., Suite 300, Boulder, CO 80302 (United States); Vokrouhlicky, David [Institute of Astronomy, Charles University, V Holesovickach 2, 180 00 Prague 8 (Czech Republic); Morbidelli, Alessandro [Departement Cassiopee, University of Nice, CNRS, Observatoire de la Cote d' Azur, Nice, F-06304 (France)

    2013-05-01

    Jupiter Trojans are thought to be survivors of a much larger population of planetesimals that existed in the planetary region when planets formed. They can provide important constraints on the mass and properties of the planetesimal disk, and its dispersal during planet migration. Here, we tested a possibility that the Trojans were captured during the early dynamical instability among the outer planets (aka the Nice model), when the semimajor axis of Jupiter was changing as a result of scattering encounters with an ice giant. The capture occurs in this model when Jupiter's orbit and its Lagrange points become radially displaced in a scattering event and fall into a region populated by planetesimals (that previously evolved from their natal transplanetary disk to {approx}5 AU during the instability). Our numerical simulations of the new capture model, hereafter jump capture, satisfactorily reproduce the orbital distribution of the Trojans and their total mass. The jump capture is potentially capable of explaining the observed asymmetry in the number of leading and trailing Trojans. We find that the capture probability is (6-8) Multiplication-Sign 10{sup -7} for each particle in the original transplanetary disk, implying that the disk contained (3-4) Multiplication-Sign 10{sup 7} planetesimals with absolute magnitude H < 9 (corresponding to diameter D = 80 km for a 7% albedo). The disk mass inferred from this work, M{sub disk} {approx} 14-28 M{sub Earth}, is consistent with the mass deduced from recent dynamical simulations of the planetary instability.

  14. Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors.

    Science.gov (United States)

    Thakore, Pratiksha I; Gersbach, Charles A

    2016-01-01

    Transcription activator-like effectors (TALEs) are modular DNA-binding proteins that can be fused to a variety of effector domains to regulate the epigenome. Nucleotide recognition by TALE monomers follows a simple cipher, making this a powerful and versatile method to activate or repress gene expression. Described here are methods to design, assemble, and test TALE transcription factors (TALE-TFs) for control of endogenous gene expression. In this protocol, TALE arrays are constructed by Golden Gate cloning and tested for activity by transfection and quantitative RT-PCR. These methods for engineering TALE-TFs are useful for studies in reverse genetics and genomics, synthetic biology, and gene therapy.

  15. Hydraulic jumps within pyroclastic density currents and their sedimentary record

    Science.gov (United States)

    Douillet, G.; Mueller, S.; Kueppers, U.; Dingwell, D. B.

    2013-12-01

    This contribution presents a complete and comprehensive formulation of the hydraulic jump phenomenon and reviews sedimentary structures that may be associated with them. Beginning from the general fluid phenomenon, we then focus on examples from pyroclastic density currents in order to infer dynamic parameters on the parent flows. A hydraulic jump is a fluid dynamics phenomenon that corresponds to the sudden increase of the thickness of a flow accompanied by a decrease of its velocity and/or density. A hydraulic jump is the expression of the transition of the flow from two different flow regimes: supercritical to subcritical. This entrains a change in the energy balance between kinetic energy and gravity potential energy. Recently, the terms of 'pneumatic jumps' have been used for similar phenomenon driven within a gas phase, and granular jumps for dense granular flows. It is thought that such strong changes in the flow conditions may leave characteristic structures in the sedimentary record. Indeed, the main variables influencing the sedimentation rate are the flow velocity, particle concentration and turbulence level, all of them strongly affected by a hydraulic jump. Structures deposited by hydraulic/pneumatic jumps have been called cyclic steps and chute and pool structures. Chute and pools represent the record of a single supercritical to subcritical transition, whereas cyclic steps are produced by stable trains of hydraulic jumps and subsequent re-accelerations. Pyroclastic density currents (PDCs) are gas and pyroclasts flows. As such, they can be subjected to granular and pneumatic jumps and their deposit have often been interpreted as containing records of jumps. Steep sided truncations covered by lensoidal layers have been interpreted as the record of internal jumps within density stratified flows. Fines-depleted breccias at breaks in slope are thought to result from the enhanced turbulence at a jump of the entire flow. Sudden increases in thickness of

  16. Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.

    Science.gov (United States)

    Reyon, Deepak; Maeder, Morgan L; Khayter, Cyd; Tsai, Shengdar Q; Foley, Jonathan E; Sander, Jeffry D; Joung, J Keith

    2013-07-01

    Customized DNA-binding domains made using transcription activator-like effector (TALE) repeats are rapidly growing in importance as widely applicable research tools. TALE nucleases (TALENs), composed of an engineered array of TALE repeats fused to the FokI nuclease domain, have been used successfully for directed genome editing in various organisms and cell types. TALE transcription factors (TALE-TFs), consisting of engineered TALE repeat arrays linked to a transcriptional regulatory domain, have been used to up- or downregulate expression of endogenous genes in human cells and plants. This unit describes a detailed protocol for the recently described fast ligation-based automatable solid-phase high-throughput (FLASH) assembly method. FLASH enables automated high-throughput construction of engineered TALE repeats using an automated liquid handling robot or manually using a multichannel pipet. Using the automated approach, a single researcher can construct up to 96 DNA fragments encoding TALE repeat arrays of various lengths in a single day, and then clone these to construct sequence-verified TALEN or TALE-TF expression plasmids in a week or less. Plasmids required for FLASH are available by request from the Joung lab (http://eGenome.org). This unit also describes improvements to the Zinc Finger and TALE Targeter (ZiFiT Targeter) web server (http://ZiFiT.partners.org) that facilitate the design and construction of FLASH TALE repeat arrays in high throughput.

  17. Determination of knock characteristics in spark ignition engines: an approach based on ensemble empirical mode decomposition

    Science.gov (United States)

    Li, Ning; Yang, Jianguo; Zhou, Rui; Liang, Caiping

    2016-04-01

    Knock is one of the major constraints to improve the performance and thermal efficiency of spark ignition (SI) engines. It can also result in severe permanent engine damage under certain operating conditions. Based on the ensemble empirical mode decomposition (EEMD), this paper proposes a new approach to determine the knock characteristics in SI engines. By adding a uniformly distributed and finite white Gaussian noise, the EEMD can preserve signal continuity in different scales and therefore alleviates the mode-mixing problem occurring in the classic empirical mode decomposition (EMD). The feasibilities of applying the EEMD to detect the knock signatures of a test SI engine via the pressure signal measured from combustion chamber and the vibration signal measured from cylinder head are investigated. Experimental results show that the EEMD-based method is able to detect the knock signatures from both the pressure signal and vibration signal, even in initial stage of knock. Finally, by comparing the application results with those obtained by short-time Fourier transform (STFT), Wigner-Ville distribution (WVD) and discrete wavelet transform (DWT), the superiority of the EEMD method in determining knock characteristics is demonstrated.

  18. A COMPARISON OF PAIRS FIGURE SKATERS IN REPEATED JUMPS

    Directory of Open Access Journals (Sweden)

    William A. Sands

    2012-03-01

    Full Text Available Trends in pairs figure skating have shown that increasingly difficult jumps have become an essential aspect of high-level performance, especially in the latter part of a competitive program. We compared a repeated jump power index in a 60 s repeated jump test to determine the relationship of repeated jump test to competitive rank and to measure 2D hip, knee, and ankle angles and angular velocities at 0, 20, 40, and 60 s. Eighteen National Team Pairs Figure Skaters performed a 60 s repeated jump test on a large switch-mat with timing of flight and ground durations and digital video recording. Each 60-s period was divided into 6, 10-s intervals, with power indexes (W/kg calculated for each 10-s interval. Power index by 10-s interval repeated measures ANOVAs (RMANOVA showed that males exceeded females at all intervals, and the highest power index interval was during 10 to 20 s for both sexes. RMANOVAs of angles and angular velocities showed main effects for time only. Power index and jumping techniques among figure skaters showed rapid and steady declines over the test duration. Power index can predict approximately 50% of competitive rank variance, and sex differences in jumping technique were rare

  19. Effects of Foam Rolling on Vertical Jump Performance

    Directory of Open Access Journals (Sweden)

    Andrew Jones

    2015-07-01

    Full Text Available Background: Foam rolling is a popular activity utilized by strength and conditioning coaches as it is believed to increase muscle length and break up fibrous adhesions located in connective tissue. However, there is little research investigating the effects of foam rolling on athletic performance. Objective: The purpose of this study was to investigate the effects of lower body foam rolling on vertical jump performance. Methods: Twenty males (age 24.05 ± 2.02 years; height 177.43 ± 6.31 cm; mass 81.41 ± 8.76 kg volunteered to participate. Subjects completed three days of testing, separated by at least twenty-four hours. Day one consisted of baseline vertical jumps on a force plate, followed by familiarization with foam rolling and control protocols. Subjects returned on days two and three and performed 30-second bouts of lower body foam rolling or mimicked foam rolling movements on a skateboard followed by vertical jumps on a force plate. The highest jump from each day was used for statistical analyses. Results: Repeated measures ANOVAs revealed no significant differences in Jump height, impulse, relative ground reaction force, or take-off velocity between conditions. Conclusion: 30-second bouts of lower body foam rolling do not improve vertical jump performance. Keywords: Dynamic Warm-Up, Foam Rolling, Vertical Jump

  20. Condensed droplet jumping: Capillary to inertial energy transfer

    Science.gov (United States)

    Enright, Ryan; Miljkovic, Nenad; Morris, Michael; Wang, Evelyn

    2013-03-01

    When condensed droplets coalesce on a superhydrophobic nanostructured surface, the resulting droplet can jump from the surface due to the release of excess surface energy. This behavior has been shown to follow a simple inertial-capillary scaling. However, questions remain regarding the nature of the energy conversion process linking the excess surface energy of the system before coalescence and the kinetic energy of the jumping droplet. Furthermore, the primary energy dissipation mechanisms limiting this jumping behavior remain relatively unexplored. In this work, we present new experimental data from a two-camera setup capturing the trajectory of jumping droplets on nanostructured surfaces with a characteristic surface roughness length scale on the order of 10 nm. Coupled with a model developed to capture the main details of the bridging flow during coalescence, our findings suggest that: 1. the excess surface energy available for jumping is a fraction of that suggested by simple scaling due to incomplete energy transfer, 2. internal viscous dissipation is not a limiting factor on the jumping process at droplet sizes on the order of 10 μm and 3. jumping performance is strongly affected by forces associated with the external flow and fields around the droplet. This work suggests bounds on the heat transfer performance of superhydrophobic condensation surfaces.

  1. Aerial jumping in the Trinidadian guppy (Poecilia reticulata).

    Science.gov (United States)

    Soares, Daphne; Bierman, Hilary S

    2013-01-01

    Many fishes are able to jump out of the water and launch themselves into the air. Such behavior has been connected with prey capture, migration and predator avoidance. We found that jumping behavior of the guppy Poecilia reticulata is not associated with any of the above. The fish jump spontaneously, without being triggered by overt sensory cues, is not migratory and does not attempt to capture aerial food items. Here, we use high speed video imaging to analyze the kinematics of the jumping behavior P. reticulata. Fish jump from a still position by slowly backing up while using its pectoral fins, followed by strong body trusts which lead to launching into the air several body lengths. The liftoff phase of the jump is fast and fish will continue with whole body thrusts and tail beats, even when out of the water. This behavior occurs when fish are in a group or in isolation. Geography has had substantial effects on guppy evolution, with waterfalls reducing gene flow and constraining dispersal. We suggest that jumping has evolved in guppies as a behavioral phenotype for dispersal.

  2. Aerial jumping in the Trinidadian guppy (Poecilia reticulata.

    Directory of Open Access Journals (Sweden)

    Daphne Soares

    Full Text Available Many fishes are able to jump out of the water and launch themselves into the air. Such behavior has been connected with prey capture, migration and predator avoidance. We found that jumping behavior of the guppy Poecilia reticulata is not associated with any of the above. The fish jump spontaneously, without being triggered by overt sensory cues, is not migratory and does not attempt to capture aerial food items. Here, we use high speed video imaging to analyze the kinematics of the jumping behavior P. reticulata. Fish jump from a still position by slowly backing up while using its pectoral fins, followed by strong body trusts which lead to launching into the air several body lengths. The liftoff phase of the jump is fast and fish will continue with whole body thrusts and tail beats, even when out of the water. This behavior occurs when fish are in a group or in isolation. Geography has had substantial effects on guppy evolution, with waterfalls reducing gene flow and constraining dispersal. We suggest that jumping has evolved in guppies as a behavioral phenotype for dispersal.

  3. Optimizing the Distribution of Leg Muscles for Vertical Jumping.

    Science.gov (United States)

    Wong, Jeremy D; Bobbert, Maarten F; van Soest, Arthur J; Gribble, Paul L; Kistemaker, Dinant A

    2016-01-01

    A goal of biomechanics and motor control is to understand the design of the human musculoskeletal system. Here we investigated human functional morphology by making predictions about the muscle volume distribution that is optimal for a specific motor task. We examined a well-studied and relatively simple human movement, vertical jumping. We investigated how high a human could jump if muscle volume were optimized for jumping, and determined how the optimal parameters improve performance. We used a four-link inverted pendulum model of human vertical jumping actuated by Hill-type muscles, that well-approximates skilled human performance. We optimized muscle volume by allowing the cross-sectional area and muscle fiber optimum length to be changed for each muscle, while maintaining constant total muscle volume. We observed, perhaps surprisingly, that the reference model, based on human anthropometric data, is relatively good for vertical jumping; it achieves 90% of the jump height predicted by a model with muscles designed specifically for jumping. Alteration of cross-sectional areas-which determine the maximum force deliverable by the muscles-constitutes the majority of improvement to jump height. The optimal distribution results in large vastus, gastrocnemius and hamstrings muscles that deliver more work, while producing a kinematic pattern essentially identical to the reference model. Work output is increased by removing muscle from rectus femoris, which cannot do work on the skeleton given its moment arm at the hip and the joint excursions during push-off. The gluteus composes a disproportionate amount of muscle volume and jump height is improved by moving it to other muscles. This approach represents a way to test hypotheses about optimal human functional morphology. Future studies may extend this approach to address other morphological questions in ethological tasks such as locomotion, and feature other sets of parameters such as properties of the skeletal

  4. Optimizing the Distribution of Leg Muscles for Vertical Jumping.

    Directory of Open Access Journals (Sweden)

    Jeremy D Wong

    Full Text Available A goal of biomechanics and motor control is to understand the design of the human musculoskeletal system. Here we investigated human functional morphology by making predictions about the muscle volume distribution that is optimal for a specific motor task. We examined a well-studied and relatively simple human movement, vertical jumping. We investigated how high a human could jump if muscle volume were optimized for jumping, and determined how the optimal parameters improve performance. We used a four-link inverted pendulum model of human vertical jumping actuated by Hill-type muscles, that well-approximates skilled human performance. We optimized muscle volume by allowing the cross-sectional area and muscle fiber optimum length to be changed for each muscle, while maintaining constant total muscle volume. We observed, perhaps surprisingly, that the reference model, based on human anthropometric data, is relatively good for vertical jumping; it achieves 90% of the jump height predicted by a model with muscles designed specifically for jumping. Alteration of cross-sectional areas-which determine the maximum force deliverable by the muscles-constitutes the majority of improvement to jump height. The optimal distribution results in large vastus, gastrocnemius and hamstrings muscles that deliver more work, while producing a kinematic pattern essentially identical to the reference model. Work output is increased by removing muscle from rectus femoris, which cannot do work on the skeleton given its moment arm at the hip and the joint excursions during push-off. The gluteus composes a disproportionate amount of muscle volume and jump height is improved by moving it to other muscles. This approach represents a way to test hypotheses about optimal human functional morphology. Future studies may extend this approach to address other morphological questions in ethological tasks such as locomotion, and feature other sets of parameters such as properties of

  5. Jumping numbers and ordered tree structures on the dual graph

    CERN Document Server

    Hyry, Eero

    2010-01-01

    Let R be a two-dimensional regular local ring having an algebraically closed residue field and let a be a complete ideal of finite colength in R. In this article we investigate the jumping numbers of a by means of the dual graph of the minimal log resolution of the pair (X,a). Our main result is a combinatorial criterium for a positive rational number to be a jumping number. In particular, we associate to each jumping number certain ordered tree structures on the dual graph.

  6. Nonstandard analysis and jump conditions for converging shock waves

    Science.gov (United States)

    Baty, Roy S.; Farassat, F.; Tucker, Don H.

    2008-06-01

    Nonstandard analysis is an area of modern mathematics that studies abstract number systems containing both infinitesimal and infinite numbers. This article applies nonstandard analysis to derive jump conditions for one-dimensional, converging shock waves in a compressible, inviscid, perfect gas. It is assumed that the shock thickness occurs on an infinitesimal interval and the jump functions in the thermodynamic and fluid dynamic parameters occur smoothly across this interval. Predistributions of the Heaviside function and the Dirac delta measure are introduced to model the flow parameters across a shock wave. The equations of motion expressed in nonconservative form are then applied to derive unambiguous relationships between the jump functions for the flow parameters.

  7. [Autogenic training in psychophysiological preparation for parachute jumps].

    Science.gov (United States)

    Reshetnikov, M M

    1978-01-01

    The efficiency of specific psychophysiological preparation--autogenic training--to parachute jumps was measured in two groups of cadets (test subjects and controls). Hetero- and autogenic training was carried out according to a scheme specially developed for this type of activity. The study of questionnaires and physiological data demonstrated that the specific psychophysiological preparation by means of autogenic training for a certain type of activity helped to develop active self-control over one's own state and emotions, alleviated tension, arrested adverse neurotic manifestations (sleep disturbances, depression, anxiety), contributed to the feeling of confidence in the successful completion of the jump and promoted positive tuning towards subsequent jumps.

  8. Stochastic mutualism model with Lévy jumps

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing; Shi, Ningzhong; Hayat, Tasawar; Alsaedi, Ahmed

    2017-02-01

    In this paper, we consider a stochastic mutualism model with Lévy jumps. First of all, we show that the positive solution of the system is stochastically ultimate bounded. Then under a simple assumption, we establish sufficient and necessary conditions for the stochastic permanence and extinction of the system. The results show an important property of the Lévy jumps: they are unfavorable for the permanence of the species. Moreover, when there are no Lévy jumps, we show that there is a unique ergodic stationary distribution of the corresponding system under certain conditions. Some numerical simulations are introduced to validate the theoretical results.

  9. RESEARCH ON JUMPING SEQUENCE PLANNING ISSUES OF HOPPING ROBOTS

    Institute of Scientific and Technical Information of China (English)

    LIUZhuang-zhi; ZHUJian-ying

    2004-01-01

    The wheeled or crawled robots often suffer from big obstacles or ditches, so a hopping robot needs to fit the tough landform in the field environments. In order to jump over obstacles rapidly, a jumping sequence must be generated based on the landform information from sensors or user input. The planning method for planar mobile robots is compared with that of hopping robots. Several factors can change the planning result. Adjusting these coefficients, a heuristic searching algorithm for the jumping sequence is developed on a simplified landform. Calculational result indicates that the algorithm can achieve safety and efficient control sequences for a desired goal.

  10. Jump-Down Performance Alterations after Space Flight

    Science.gov (United States)

    Reschke, M. F.; Kofman, I. S.; Cerisano, J. M.; Fisher, E. A.; Peters, B. T.; Miller, C. A.; Harm, D. L.; Bloomberg, J. J.

    2011-01-01

    INTRODUCTION: Successful jump performance requires functional coordination of visual, vestibular, and somatosensory systems, which are affected by prolonged exposure to microgravity. Astronauts returning from space flight exhibit impaired ability to coordinate effective landing strategies when jumping from a platform to the ground. This study compares jump strategies used by astronauts before and after flight, changes to those strategies within a test session, and recoveries in jump-down performance parameters across several postflight test sessions. These data were obtained as part of an ongoing interdisciplinary study (Functional Task Test, FTT) designed to evaluate both astronaut postflight functional performance and related physiological changes. METHODS: Seven astronauts from short-duration (Shuttle) and three from long-duration (International Space Station) flights performed 3 two-footed jumps from a platform 30 cm high onto a force plate that measured the ground reaction forces and center-of-pressure displacement from the landings. Neuromuscular activation data were collected from the medial gastrocnemius and anterior tibialis of both legs using surface electromyography electrodes. Two load cells in the platform measured the load exerted by each foot during the takeoff phase of the jump. Data were collected in 2 preflight sessions, on landing day (Shuttle only), and 1, 6, and 30 days after flight. RESULTS: Postural settling time was significantly increased on the first postflight test session and many of the astronauts tested were unable to maintain balance on their first jump landing but recovered by the third jump, showing a learning progression in which performance improvements could be attributed to adjustments in takeoff or landing strategy. Jump strategy changes were evident in reduced air time (time between takeoff and landing) and also in increased asymmetry in foot latencies on takeoff. CONCLUSIONS: The test results revealed significant decrements

  11. Detection of weak frequency jumps for GNSS onboard clocks.

    Science.gov (United States)

    Huang, Xinming; Gong, Hang; Ou, Gang

    2014-05-01

    In this paper, a weak frequency jump detection method is developed for onboard clocks in global navigation satellite systems (GNSS). A Kalman filter is employed to facilitate the onboard real-time processing of atomic clock measurements, whose N-step prediction residuals are used to construct the weak frequency jump detector. Numerical simulations show that the method can successfully detect weak frequency jumps. The detection method proposed in this paper is helpful for autonomous integrity monitoring of GNSS satellite clocks, and can also be applied to other frequency anomalies with an appropriately modified detector.

  12. Jump diffusion models and the evolution of financial prices

    Science.gov (United States)

    Figueiredo, Annibal; de Castro, Marcio T.; da Silva, Sergio; Gleria, Iram

    2011-08-01

    We analyze a stochastic model to describe the evolution of financial prices. We consider the stochastic term as a sum of the Wiener noise and a jump process. We point to the effects of the jumps on the return time evolution, a central concern of the econophysics literature. The presence of jumps suggests that the process can be described by an infinitely divisible characteristic function belonging to the De Finetti class. We then extend the De Finetti functions to a generalized nonlinear model and show the model to be capable of explaining return behavior.

  13. Influence of stretching on warm up in jump and speed

    OpenAIRE

    Gálvez Ruiz, Pablo; Tapia Flores, A; Jurado Lavanant, A

    2013-01-01

    El objetivo del estudio es determinar si la realización de estiramientos pasivos, incluidos como parte del calentamiento, influyen en el rendimiento de la fuerza explosiva, en este caso en varios tests de salto vertical: Squat Jump (SJ), Countermouvement Jump (CMJ) y Reactive Jump (RJ); y también en un test de velocidad de 30 metros (mts.) con salida lanzada de 5 mts. Para ello, 9 jugadores del Málaga Club de Fútbol de categoría juvenil (18,22 ± 0,441 años) realizaron 2 protocolos de...

  14. Asymptotic Distribution of the Jump Change-Point Estimator

    Institute of Scientific and Technical Information of China (English)

    Changchun TAN; Huifang NIU; Baiqi MIAO

    2012-01-01

    The asymptotic distribution of the change-point estimator in a jump changepoint model is considered.For the jump change-point model Xi =a + θI{[nTo] < i ≤n} + εi,where εi (i =1,…,n) are independent identically distributed random variables with Eεi=0 and Var(εi) < oo,with the help of the slip window method,the asymptotic distribution of the jump change-point estimator (T) is studied under the condition of the local alternative hypothesis.

  15. Quantum jumps induced by matter-wave fluctuations

    CERN Document Server

    Torres, J M; Zippilli, S; Morigi, G

    2010-01-01

    We theoretically study the occurrence of quantum jumps in the resonance fluorescence of a trapped atom. Here, the atom is laser cooled in a configuration of level such that the occurrence of a quantum jump is associated to a change of the vibrational center-of-mass motion by one phonon. The statistics of the occurrence of the dark fluorescence period is studied as a function of the physical parameters and the corresponding features in the spectrum of resonance fluorescence are identified. We discuss the information which can be extracted on the atomic motion from the observation of a quantum jump in the considered setup.

  16. Rate Theory for Correlated Processes: Double Jumps in Adatom Diffusion

    DEFF Research Database (Denmark)

    Jacobsen, J.; Jacobsen, Karsten Wedel; Sethna, J.

    1997-01-01

    We study the rate of activated motion over multiple barriers, in particular the correlated double jump of an adatom diffusing on a missing-row reconstructed platinum (110) surface. We develop a transition path theory, showing that the activation energy is given by the minimum-energy trajectory...... which succeeds in the double jump. We explicitly calculate this trajectory within an effective-medium molecular dynamics simulation. A cusp in the acceptance region leads to a root T prefactor for the activated rate of double jumps. Theory and numerical results agree....

  17. Vlade Divac: Unfinished transition fairy tale

    Directory of Open Access Journals (Sweden)

    Đorđević Ivan

    2007-01-01

    Full Text Available In this work I try to establish, by analyzing texts about basketball player Vlade Divac, in what way sport press is representing famous individual sport personalities, as well as strategies with which media is representing but also socially constructs specific identification practices, primarily those connected with the concept of national identity. In doing that, I am starting from the fact that professional sportsmen represent typical example of "transnational citizens and global businessmen who simultaneously inhabit both national and transnational space", but at the same time, consciously and seemingly paradoxically can serve as "national cultural icons in the function of forming and reaffirming national identities". Analyzed details from media presentations of Vlade Divca point out that the smallest common denominator that brought to the basketball player such status is the "proven patriotism". The picture being formed about him represents a series of preferred national characteristics, a quintessence of "Serbian people", thanks to which or even in spite of that, he succeeds to overcome, in the perception here, not too positively co notated America. Also, I am trying to point out how media story about well known basketball player has a structure of transitional fairy tale in which Divac is playing the role of "hero" of the still unfinished transition in Serbia.

  18. Policy Pathways: A Tale of Renewed Cities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-01

    Transport currently accounts for half of global oil consumption and nearly 20% of world energy use, of which approximately 40% is used in urban transport alone. The IEA expects urban transport energy consumption to double by 2050, despite ongoing vehicle technology and fuel-economy improvements. While increased mobility brings many benefits, the staggering rate of this increase creates new challenges. Urgent energy-efficiency policy attention will be needed to mitigate associated negative noise, air pollution, congestion, climate and economic impacts, all of which can cost countries billions of dollars per year. This report highlights lessons learned and examples of good practice from countries with experience implementing a wide range of measures to improve energy efficiency in urban transport systems. Part of the IEA Policy Pathway series, A Tale of Renewed Cities sets out key steps in planning, implementation, monitoring and evaluation to achieve improved energy efficiency in urban transport systems. The Policy Pathway series aims to help policy makers implement the IEA 25 Energy Efficiency Policy Recommendations.

  19. Opioid Use in Fibromyalgia: A Cautionary Tale.

    Science.gov (United States)

    Goldenberg, Don L; Clauw, Daniel J; Palmer, Roy E; Clair, Andrew G

    2016-05-01

    Multiple pharmacotherapies are available for the treatment of fibromyalgia (FM), including opioid analgesics. We postulate that the mechanism of action of traditional opioids predicts their lack of efficacy in FM. Literature searches of the MEDLINE and Cochrane Library databases were conducted using the search term opioid AND fibromyalgia to identify relevant articles, with no date limitations set. Citation lists in returned articles and personal archives of references were also examined for additional relevant items, and articles were selected based on the expert opinions of the authors. We found no evidence from clinical trials that opioids are effective for the treatment of FM. Observational studies have found that patients with FM receiving opioids have poorer outcomes than patients receiving nonopioids, and FM guidelines recommend against the use of opioid analgesics. Despite this, and despite the availability of alternative Food and Drug Administration-approved pharmacotherapies and the efficacy of nonpharmacologic therapies, opioids are commonly used in the treatment of FM. Factors associated with opioid use include female sex; geographic variation; psychological factors; a history of opioid use, misuse, or abuse; and patient or physician preference. The long-term use of opioid analgesics is of particular concern in the United States given the ongoing public health emergency relating to excess prescription opioid consumption. The continued use of opioids to treat FM despite a proven lack of efficacy, lack of support from treatment guidelines, and the availability of approved pharmacotherapy options provides a cautionary tale for their use in other chronic pain conditions.

  20. “Souls of the ancestor that knock us out” and other tales. A qualitative study to identify demand-side factors influencing malaria case management in Cambodia

    Directory of Open Access Journals (Sweden)

    O’Connell Kathryn A

    2012-10-01

    Full Text Available Abstract Background Appropriate case management of suspected malaria in Cambodia is critical given anti-malarial drug resistance in the region. Improving diagnosis and the use of recommended malarial treatments is a challenge in Cambodia where self-treatment and usage of drug cocktails is widespread, a notable difference from malaria treatment seeking in other countries. This qualitative study adds to the limited evidence base on Cambodian practices, aiming to understand the demand-side factors influencing treatment-seeking behaviour, including the types of home treatments, perceptions of cocktail medicines and reasons for diagnostic testing. The findings may help guide intervention design. Methods The study used in-depth interviews (IDIs (N = 16 and focus group discussions (FGDs (N = 12 with Cambodian adults from malaria-endemic areas who had experienced malaria fever in the previous two weeks. Data were analysed using NVivo software. Results Findings suggest that Cambodians initially treat suspected malaria at home with home remedies and traditional medicines. When seeking treatment outside the home, respondents frequently reported receiving a cocktail of medicines from trusted providers. Cocktails are perceived as less expensive and more effective than full-course, pre-packaged medicines. Barriers to diagnostic testing include a belief in the ability to self-diagnose based on symptoms, cost and reliance on providers to recommend a test. Factors that facilitate testing include recommendation by trusted providers and a belief that anti-malarial treatment for illnesses other than malaria can be harmful. Conclusions Treatment-seeking behaviour for malaria in Cambodia is complex, driven by cultural norms, practicalities and episode-related factors. Effective malaria treatment programmes will benefit from interventions and communication materials that leverage these demand-side factors, promoting prompt visits to facilities for suspected malaria and challenging patients’ misconceptions about the effectiveness of cocktails. Given the importance of the patient-provider interaction and the pivotal role that providers play in ensuring the delivery of appropriate malaria care, future research and interventions should also focus on the supply side factors influencing provider behaviour.

  1. Aeromechanics of the Spider Cricket Jump: How to Jump 60+ Times Your Body Length and Still Land on Your Feet

    Science.gov (United States)

    Palmer, Emily; Deshler, Nicolas; Gorman, David; Neves, Catarina; Mittal, Rajat

    2015-11-01

    Flapping, gliding, running, crawling and swimming have all been studied extensively in the past and have served as a source of inspiration for engineering designs. In the current project, we explore a mode of locomotion that straddles ground and air: jumping. The subject of our study is among the most proficient of long-jumpers in Nature: the spider cricket of the family Rhaphidophoridae, which can jump more than 60 times its body length. Despite jumping this immense distance, these crickets usually land on their feet, indicating an ability to control their posture during ``flight.'' We employ high-speed videogrammetry, to examine the jumps and to track the crickets' posture and appendage orientation throughout their jumps. Simple aerodynamic models are developed to predict the aerodynamic forces and moment on the crickets during `flight`. The analysis shows that these wingless insects employ carefully controlled and coordinated positioning of the limbs during flight so as to increase jump distance and to stabilize body posture during flight. The principles distilled from this study could serve as an inspiration for small jumping robots that can traverse complex terrains.

  2. USEFULNESS AND METABOLIC IMPLICATIONS OF A 60-SECOND REPEATED JUMPS TEST AS A PREDICTOR OF ACROBATIC JUMPING PERFORMANCE IN GYMNASTS

    Directory of Open Access Journals (Sweden)

    Ferran Antoni Rodriguez

    2013-01-01

    Full Text Available Gymnastics floor exercises are composed of a set of four to five successive acrobatic jumps usually called a �series�. The aims of the study were: 1 to relate the acrobatic gymnastics performance of these series with a repeated jumps test of similar duration (R60, 2 to study the relation between R60 and physiological parameters (heart rate and blood lactate, and the performance obtained in different kinds of jumps, 3 to confirm whether R60, executed without a damped jumping technique, can be considered an anaerobic lactic power test. Twenty male and twenty-four female gymnasts performed three repeated jumps tests for 5 s (R5, 10 s (R10 and 60 s (R60 and vertical jumps, such as drop jumps (DJ, squat jumps (SJ and countermovement jumps (CMJ. We assessed heart rate (HR and blood lactate during R10 and R60. The average values of the maximal blood lactate concentration (Lmax after R10 (males = 2.5±0.6 mmol.l-1; females = 2.1±0.8 mmol.l-1 confirm that anaerobic glycolysis is not activated to a high level. In R60, the Lmax (males = 7.5±1.7 mmol.l-1; females = 5.9±2.1 mmol.l-1 that was recorded does not validate R60 as an anaerobic lactic power test. We confirmed the relation between the average power obtained in R60 (R60Wm and the acrobatic performance on the floor. The inclusion in the multiple regression equation of the best power in DJ and the best flight-contact ratio (FC in R5 confirms the influence of other non-metabolic components on the variability in R60 performance, at least in gymnasts.

  3. Conformational elasticity can facilitate TALE-DNA recognition.

    Science.gov (United States)

    Lei, Hongxing; Sun, Jiya; Baldwin, Enoch P; Segal, David J; Duan, Yong

    2014-01-01

    Sequence-programmable transcription activator-like effector (TALE) proteins have emerged as a highly efficient tool for genome engineering. Recent crystal structures depict a transition between an open unbound solenoid and more compact DNA-bound solenoid formed by the 34 amino acid repeats. How TALEs switch conformation between these two forms without substantial energetic compensation, and how the repeat-variable di-residues (RVDs) discriminate between the cognate base and other bases still remain unclear. Computational analysis on these two aspects of TALE-DNA interaction mechanism has been conducted in order to achieve a better understanding of the energetics. High elasticity was observed in the molecular dynamics simulations of DNA-free TALE structure that started from the bound conformation where it sampled a wide range of conformations including the experimentally determined apo and bound conformations. This elastic feature was also observed in the simulations starting from the apo form which suggests low free energy barrier between the two conformations and small compensation required upon binding. To analyze binding specificity, we performed free energy calculations of various combinations of RVDs and bases using Poisson-Boltzmann surface area (PBSA) and other approaches. The PBSA calculations indicated that the native RVD-base structures had lower binding free energy than mismatched structures for most of the RVDs examined. Our theoretical analyses provided new insight on the dynamics and energetics of TALE-DNA binding mechanism.

  4. Chimeric TALE recombinases with programmable DNA sequence specificity.

    Science.gov (United States)

    Mercer, Andrew C; Gaj, Thomas; Fuller, Roberta P; Barbas, Carlos F

    2012-11-01

    Site-specific recombinases are powerful tools for genome engineering. Hyperactivated variants of the resolvase/invertase family of serine recombinases function without accessory factors, and thus can be re-targeted to sequences of interest by replacing native DNA-binding domains (DBDs) with engineered zinc-finger proteins (ZFPs). However, imperfect modularity with particular domains, lack of high-affinity binding to all DNA triplets, and difficulty in construction has hindered the widespread adoption of ZFPs in unspecialized laboratories. The discovery of a novel type of DBD in transcription activator-like effector (TALE) proteins from Xanthomonas provides an alternative to ZFPs. Here we describe chimeric TALE recombinases (TALERs): engineered fusions between a hyperactivated catalytic domain from the DNA invertase Gin and an optimized TALE architecture. We use a library of incrementally truncated TALE variants to identify TALER fusions that modify DNA with efficiency and specificity comparable to zinc-finger recombinases in bacterial cells. We also show that TALERs recombine DNA in mammalian cells. The TALER architecture described herein provides a platform for insertion of customized TALE domains, thus significantly expanding the targeting capacity of engineered recombinases and their potential applications in biotechnology and medicine.

  5. [Effects of Reactive Jump Training in Handball Players Regarding Jump Height and Power Development in the Triceps Surae Muscle].

    Science.gov (United States)

    Rensing, N; Westermann, A; Möller, D; von Piekartz, H

    2015-12-01

    Studies have shown changes in the technical and physical demands in modern handball. The game has increased considerably in speed, power and dynamics. Jump training has, therefore, become ever more important in the training of the athletes. These developments contribute to the fact that handball is now one of the most injury-prone types of sport, with the lower extremities being most frequently affected. Reactive jump training is not only used in training by now, but also increasingly in injury prevention. The aim of this study was to investigate the effectiveness of reactive jump training with handball players. 21 regional league handball players were randomly divided into an intervention group (n = 12) and a control group (n = 9). The intervention group completed a six-week reactive jump training programme while the control group went through a non-specific training programme. Jump height (squat and counter movement jump), isokinetic and isometric maximum power as well as muscle activity served as measuring parameters. A comparison of the intervention and control groups revealed that the reactive jump training led to significant improvements in jump height. The isometric and isokinetic maximum power measurements and the electromyographic activities of the triceps surae muscle demonstrated an improvement in the values within the intervention group. However, this improvement was not significant compared with the control group. Likewise both jumps correlated with the muscle activity of the soleus muscle as shown by electromyography. A moderate correlation was noticed between the isokinetic maximum power measurement and the electromyographic activity of the soleus and gastrocnemius medialis muscles. Furthermore, the correlations of the isometric and isokinetic maximum power meas-urements resulted in a strong correlation coefficient. This study revealed a significant increase in jump height after reactive jump training. There was no significant difference in

  6. Testability Synthesis for Jumping Carry Adders

    Directory of Open Access Journals (Sweden)

    Chien-In Henry Chen

    2002-01-01

    Full Text Available Synthesis for testability ensures that the synthesized circuit is testable by exploring the fundamental relationship between don't care and redundancy. With the exploration of the relationship, redundancy removal can be applied to improve the testability, reduce the area and improve the speed of a synthesized circuit. The test generation problems have been adequately solved, therefore an innovative testability synthesis strategy is necessary for achieving the maximum fault coverage and area reduction for maximum speed. This paper presents a testability synthesis methodology applicable to a top–down design method based on the identification and removal of redundant faults. Emphasis has been placed on the testability synthesis of a high-speed binary jumping carry adder. A synthesized 32-bit testable adder implemented by a 1.2 μm CMOS technology performs addition in 4.09 ns. Comparing with the original synthesized circuit, redundancy removal yields a 100% testable design with a 15% improvement in speed and a 25% reduction in area.

  7. Vortex jump behavior in coupled nanomagnetic heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, S.; Phatak, C., E-mail: cd@anl.gov [Materials Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois 60439 (United States); Petford-Long, A. K. [Materials Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois 60439 (United States); Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208 (United States); Heinonen, O. [Materials Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois 60439 (United States); Department of Physics and Astronomy, Northwestern University, 2145 Sheridan Rd, Evanston, Illinois 60208-3112 (United States)

    2014-11-24

    The spin configuration and magnetic behavior in patterned nanostructures can be controlled by manipulating the interplay between the competing energy terms. This in turn requires fundamental knowledge of the magnetic interactions at the local nanometer scale. Here, we report on the spin structure and magnetization behavior of patterned discs containing exchange coupled ferromagnetic layers with additional exchange bias to an antiferromagnetic layer. The magnetization reversal was explored by direct local visualization of the domain behavior using in-situ Lorentz transmission electron microscopy, from which quantitative magnetic induction maps were reconstructed. The roles of the main competing energy terms were elucidated and the reversal mechanism was identified as a coupled phenomenon of incoherent rotation in the exchange-biased layer and localized vortex nucleation and discontinuous propagation in the free layer, including an anomalous jump in the trajectory. The observations were supported by micromagnetic simulations and modeled phase shift simulations. The work presented here provides fundamental insights into opportunities for macroscopic control of the energy landscape of magnetic heterostructures for functional applications.

  8. Ethics in radiology: wait lists queue jumping.

    Science.gov (United States)

    Cunningham, Natalie; Reid, Lynette; MacSwain, Sarah; Clarke, James R

    2013-08-01

    Education in ethics is a requirement for all Royal College residency training programs as laid out in the General Standards of Accreditation for residency programs in Canada. The ethical challenges that face radiologists in clinical practice are often different from those that face other physicians, because the nature of the physician-patient interaction is unlike that of many other specialties. Ethics education for radiologists and radiology residents will benefit from the development of teaching materials and resources that focus on the issues that are specific to the specialty. This article is intended to serve as an educational resource for radiology training programs to facilitate teaching ethics to residents and also as a continuing medical education resource for practicing radiologists. In an environment of limited health care resources, radiologists are frequently asked to expedite imaging studies for patients and, in some respects, act as gatekeepers for specialty care. The issues of wait lists, queue jumping, and balancing the needs of individuals and society are explored from the perspective of a radiologist.

  9. A jumping shape memory alloy under heat.

    Science.gov (United States)

    Yang, Shuiyuan; Omori, Toshihiro; Wang, Cuiping; Liu, Yong; Nagasako, Makoto; Ruan, Jingjing; Kainuma, Ryosuke; Ishida, Kiyohito; Liu, Xingjun

    2016-02-16

    Shape memory alloys are typical temperature-sensitive metallic functional materials due to superelasticity and shape recovery characteristics. The conventional shape memory effect involves the formation and deformation of thermally induced martensite and its reverse transformation. The shape recovery process usually takes place over a temperature range, showing relatively low temperature-sensitivity. Here we report novel Cu-Al-Fe-Mn shape memory alloys. Their stress-strain and shape recovery behaviors are clearly different from the conventional shape memory alloys. In this study, although the Cu-12.2Al-4.3Fe-6.6Mn and Cu-12.9Al-3.8Fe-5.6Mn alloys possess predominantly L2(1) parent before deformation, the 2H martensite stress-induced from L2(1) parent could be retained after unloading. Furthermore, their shape recovery response is extremely temperature-sensitive, in which a giant residual strain of about 9% recovers instantly and completely during heating. At the same time, the phenomenon of the jumping of the sample occurs. It is originated from the instantaneous completion of the reverse transformation of the stabilized 2H martensite. This novel Cu-Al-Fe-Mn shape memory alloys have great potentials as new temperature-sensitive functional materials.

  10. Triple jump examinations for dental student assessment.

    Science.gov (United States)

    Navazesh, Mahvash; Rich, Sandra K; Chopiuk, Nasrin Bahari; Keim, Robert G

    2013-10-01

    The triple jump examination (TJE) attempts to assess a higher level of learning with demand for analysis, critical thinking, and resolution of problems presented by written scenarios based on patient care situations. The purpose of this study was to examine the internal consistency, scale reliability, and interrater reliability of the TJE used at the Ostrow School of Dentistry, University of Southern California. On the sample of 2,227 examinations administered by seventy-seven raters across a three-year time period, the Cronbach's coefficient alpha for internal consistency of the overall TJE was found to be good (a=0.869). The internal consistency of the three subscales was found to be acceptable (a=0.731), good (a=0.820), and good (a=0.820). Average and single measures intraclass correlation coefficients (ICC) for scale reliability were significant at p<0.001, indicating strong interrater reliability. There were no statistically significant differences (p≤0.05) in the mean scores assigned on the TJE between rater groups defined by rater experience level with the TJE. A very high level of agreement among rater pairs was also observed. Across the entire three-year study period, with over 19,152 ratings, the seventy-seven raters were in general agreement 99.5 percent of the time and in exact agreement 77.2 percent of the time.

  11. SOLUTION TO BSDE WITH NONHOMOGENEOUS JUMPS UNDER LOCALLY LIPSCHITZIAN CONDITION

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper, we investigate the existence and uniqueness of the solution to a quasilinear backward stochastic differential equation with Poisson jumps. By introducing a series of approximate equations, we can show that BSDE has a unique adapted solution.

  12. Spontaneous Jumping of Coalescing Drops on a Superhydrophobic Surface

    Science.gov (United States)

    Boreyko, Jonathan; Chen, Chuan-Hua

    2009-11-01

    When micrometric drops coalesce in-plane on a superhydrophobic surface, a surprising out-of-plane jumping motion was observed. Such jumping motion triggered by drop coalescence was reproduced on a Leidenfrost surface. High-speed imaging revealed that this jumping motion results from the elastic interaction of the bridged drops with the superhydrophobic/Leidenfrost surface. Experiments on both the superhydrophobic and Leidenfrost surfaces compare favorably to a simple scaling model relating the kinetic energy of the merged drop to the surface energy released upon coalescence. The spontaneous jumping motion on water repellent surfaces enables the autonomous removal of water condensate independently of gravity; this process is highly desirable for sustained dropwise condensation.

  13. Spontaneous Jumping of Coalescing Drops on a Superhydrophobic Surface

    CERN Document Server

    Boreyko, Jonathan

    2009-01-01

    When micrometric drops coalesce in-plane on a superhydrophobic surface, a surprising out-of-plane jumping motion was observed. Such jumping motion triggered by drop coalescence was reproduced on a Leidenfrost surface. High-speed imaging revealed that this jumping motion results from the elastic interaction of the bridged drops with the superhydrophobic/Leidenfrost surface. Experiments on both the superhydrophobic and Leidenfrost surfaces compare favorably to a simple scaling model relating the kinetic energy of the merged drop to the surface energy released upon coalescence. The spontaneous jumping motion on water repellent surfaces enables the autonomous removal of water condensate independently of gravity; this process is highly desirable for sustained dropwise condensation.

  14. Jump Testing and the Speed of Market Adjustment

    DEFF Research Database (Denmark)

    Rasmussen, Torben B.

    Asymptotic properties of jump tests rely on the property that any jump occurs within a single time interval no matter what the observation frequency is. Market microstructure effects in relation to news-induced revaluation of the underlying variable is likely to make this an unrealistic assumption...... for high-frequency transaction data. To capture these microstructure effects, this paper suggests a model in which market prices adjust gradually to jumps in the underlying effcient price. A case study illustrates the empirical relevance of the model, and the performance of different jump tests...... is investigated here and in a simulation study. Evidence indicates that tests based on the largest of scaled price increments perform better than tests comparing measures of variability. Resolving the matter by testing at lower frequencies turns out to be less straightforward....

  15. Stick-jump mode in surface droplet dissolution

    CERN Document Server

    Dietrich, Erik; Zhang, Xuehua; Zandvliet, Harold J W; Lohse, Detlef

    2016-01-01

    The analogy between evaporating surface droplets in air to dissolving long-chain alcohol droplets in water is worked out. We show that next to the three known modi for surface droplet evaporation or dissolution (constant contact angle mode, constant contact radius mode, and stick-slide mode), a fourth mode exists for small droplets on supposedly smooth substrates, namely the stick-jump mode: intermittent contact line pinning causes the droplet to switch between sticking and jumping during the dissolution. We present experimental data and compare them to theory to predict the dissolution time in this stick-jump mode. We also explain why these jumps were easily observed for microscale droplets but not for larger droplets.

  16. METRIC TESTS CHARACTERISTIC FOR ESTIMATING JUMPING FOR VOLLEYBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Toplica Stojanović

    2008-08-01

    Full Text Available With goal to establish metric tests characteristics for estimating jumping for volleyball players, it was organized a pilot research on pattern of 23 volleyball players from cadet team and 23 students from high-school. For needs of this research four tests are valid for estimation, jump in block with left and right leg and jump in spike with left and right leg. Each test has been taken three times, so that we could with test-re test method determine their reliability, and with factor analysis their validity. Data were processed by multivariate analysis (item analysis, factor analysis from statistical package „Statistica 6.0 for windows“. On the results of research and discussion we can say that the tests had high coefficient of reliability, as well as factor validity, and these tests can be used to estimate jumping for volleyball players.

  17. Bird Flu Strain May Have Jumped from Cat to Human

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162717.html Bird Flu Strain May Have Jumped From Cat to ... would be the first known transmission of this bird flu strain from cat to human, officials said. ...

  18. Spontaneous azimuthal breakout and instability at the circular hydraulic jump

    CERN Document Server

    Ray, Arnab K; Basu, Abhik; Bhattacharjee, Jayanta K

    2015-01-01

    We consider a shallow, two-dimensional flow of a liquid in which the radial and the azimuthal dynamics are coupled to each other. The steady and radial background flow of this system creates an axially symmetric circular hydraulic jump. On this background we apply time-dependent perturbations of the matter flow rate and the azimuthal flow velocity, with the latter strongly localized at the hydraulic jump. The perturbed variables depend spatially on both the radial and azimuthal coordinates. Linearization of the perturbations gives a coupled system of wave equations. The characteristic equations extracted from these wave equations show that under a marginally stable condition a spontaneous breaking of axial symmetry occurs at the position of the hydraulic jump. Departure from the marginal stability shows further that a linear instability develops in the azimuthal direction, resulting in an azimuthal transport of liquid at the hydraulic jump. The time for the growth of azimuthal instability is scaled by viscosi...

  19. The fluid dynamics of swimming by jumping in copepods

    DEFF Research Database (Denmark)

    Jiang, Houshuo; Kiørboe, Thomas

    2011-01-01

    Copepods swim either continuously by vibrating their feeding appendages or erratically by repeatedly beating their swimming legs resulting in a series of small jumps. The two swimming modes generate different hydrodynamic disturbances and therefore expose the swimmers differently to rheotactic...... limited and temporally ephemeral owing to jump-impulsiveness and viscous decay. In contrast, continuous steady swimming generates two well-extended long-lasting momentum jets both in front of and behind the swimmer, as suggested by the well-known steady stresslet model. Based on the observed jump-swimming...... kinematics of a small copepod Oithona davisae, we further showed that jump-swimming produces a hydrodynamic disturbance with much smaller spatial extension and shorter temporal duration than that produced by a same-size copepod cruising steadily at the same average translating velocity. Hence, small copepods...

  20. The fluid dynamics of swimming by jumping in copepods

    DEFF Research Database (Denmark)

    Jiang, Houshuo; Kiørboe, Thomas

    2011-01-01

    Copepods swim either continuously by vibrating their feeding appendages or erratically by repeatedly beating their swimming legs resulting in a series of small jumps. The two swimming modes generate different hydrodynamic disturbances and therefore expose the swimmers differently to rheotactic...... limited and temporally ephemeral owing to jump-impulsiveness and viscous decay. In contrast, continuous steady swimming generates two well-extended long-lasting momentum jets both in front of and behind the swimmer, as suggested by the well-known steady stresslet model. Based on the observed jump-swimming...... kinematics of a small copepod Oithona davisae, we further showed that jump-swimming produces a hydrodynamic disturbance with much smaller spatial extension and shorter temporal duration than that produced by a same-size copepod cruising steadily at the same average translating velocity. Hence, small copepods...

  1. Jump diffusion models and the evolution of financial prices

    Energy Technology Data Exchange (ETDEWEB)

    Figueiredo, Annibal; Castro, Marcio T. de [Institute of Physics, University of Brasilia (Brazil); Silva, Sergio da [Department of Economics, Federal University of Santa Catarina (Brazil); Gleria, Iram, E-mail: iram@pq.cnpq.br [Institute of Physics, Federal University of Alagoas (Brazil)

    2011-08-08

    We analyze a stochastic model to describe the evolution of financial prices. We consider the stochastic term as a sum of the Wiener noise and a jump process. We point to the effects of the jumps on the return time evolution, a central concern of the econophysics literature. The presence of jumps suggests that the process can be described by an infinitely divisible characteristic function belonging to the De Finetti class. We then extend the De Finetti functions to a generalized nonlinear model and show the model to be capable of explaining return behavior. -- Highlights: → We analyze a stochastic model to describe the evolution of financial prices. → The stochastic term is considered as a sum of the Wiener noise and a jump process. → The process can be described by an infinitely divisible characteristic function belonging to the De Finetti class. → We extend the De Finetti functions to a generalized nonlinear model.

  2. Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method)

    DEFF Research Database (Denmark)

    Hansen, Susanne Brunsgaard; Berg, Rolf W.; Stenby, Erling Halfdan

    Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method). See poster at http://www.kemi.dtu.dk/~ajo/rolf/jumps.pdf......Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method). See poster at http://www.kemi.dtu.dk/~ajo/rolf/jumps.pdf...

  3. Writing and Retelling Multiple Ethnographic Tales of a Soup Kitchen for the Homeless.

    Science.gov (United States)

    Miller, Dana L.; Creswell, John W.; Olander, Lisa

    An ethnographic study narrated three tales about a soup kitchen for the homeless and the near-homeless. To provide a cultural, ethnographic analysis, and share fieldwork experiences the study began with realist and confessional tales. These two tales emerged from the initial writing and presenting of the soup kitchen ethnography to qualitative…

  4. Fundamental Studies of Jumping-Drop Thermal Diodes

    Science.gov (United States)

    2016-02-29

    Reverse mode with liquid trapped by the colder superhydrophilic surface. ............... 2 Figure 2. Fabrication of the jumping-drop thermal diode...mode, Figure 1b), liquid water is trapped by it and no phase-change heat transfer takes place; heat mainly escapes through ineffective conduction...self- propelled jumping drops returning the working fluid from the colder superhydrophobic surface; (b) Reverse mode with liquid trapped by the colder

  5. ANALYSIS OF INCOMPLETE STOCK MARKET WITH JUMP-DIFFUSION UNCERTAINTY

    Institute of Scientific and Technical Information of China (English)

    Xiuli Chao; Indrajit Bardhan

    2002-01-01

    This paper studies incomplete stock market that includes discontinuous priceprocesses. The discontinuity is modeled by very general point processes admitting onlystochastic intensities. Prices are driven by jump-diffusion uncertainty and have randombut predictable jumps. The space of risk-neutral measures that are associated with themarket is identified and related to fictitious completions. The construction of replicatingportfolios is discussed, and convex duality methods are used to prove existence of optimalconsumption and investment policies for a problem of utility maximization.

  6. Nonlinear H∞ filtering for interconnected Markovian jump systems

    Institute of Scientific and Technical Information of China (English)

    Zhang Xiaomei; Zheng Yufan

    2006-01-01

    The problem of nonlinear H∞ filtering for interconnected Markovian jump systems is discussed. The aim of this note is the design of a nonlinear Markovian jump filter such that the resulting error system is exponentially meansquare stable and ensures a prescribed H∞ performance. A sufficient condition for the solvability of this problem is given in terms of linear matrix inequalities(LMIs). A simulation example is presented to demonstrate the effectiveness of the proposed design approach.

  7. Psycho-physiological response in an automatic parachute jump

    OpenAIRE

    Clemente Suárez, Vicente Javier; Robles Pérez, José Juan; Fernández Lucas, Jesús

    2016-01-01

    Parachute jump is an extreme activity that elicits an intense stress response that affects jumpers' body systems being able to put them at risk. The present research analysed modifications in blood oxygen saturation (BOS), heart rate (HR), cortisol, glucose, lactate, creatine kinase (CK), muscles strength, cortical arousal, autonomic modulation, pistol magazine reload time (PMRT) and state anxiety before and after an automatic open parachute jump in 38 male Spanish soldiers (25.6 ± 5.9 years)...

  8. Gravity-free hydraulic jumps and metal femtocups

    OpenAIRE

    Govindarajan, Rama; Mathur, Manikandan; DasGupta, Ratul; Selvi, N. R.; John, Neena Susan; Kulkarni, G. U.

    2006-01-01

    Hydraulic jumps created by gravity are seen every day in the kitchen sink. We show that at small scales a circular hydraulic jump can be created in the absence of gravity, by surface tension. The theory is motivated by our experimental finding of a height discontinuity in spreading submicron molten metal droplets created by pulsed-laser ablation. By careful control of initial conditions, we show that this leads to solid femtolitre cups of gold, silver, copper, niobium and tin.

  9. Smoothed Particle Hydrodynamic of Hydraulic Jumps in Spillways

    OpenAIRE

    Jonsson, Patrick

    2015-01-01

    This thesis focus on the complex natural phenomena of hydraulic jumps using the numerical method Smoothed Particle Hydrodynamics (SPH). A hydraulic jump is highly turbulent and associated with turbulent energy dissipation, air entrainment, surface waves and spray and strong dissipative processes. It can be found not only in natural streams and in engineered open channels, but also in your kitchen sink at home. The dissipative features are utilized in hydropower spillways and stilling basins t...

  10. Gravity-free hydraulic jumps and metal femtoliter cups.

    Science.gov (United States)

    Mathur, Manikandan; DasGupta, Ratul; Selvi, N R; John, Neena Susan; Kulkarni, G U; Govindarajan, Rama

    2007-04-20

    Hydraulic jumps created by gravity are seen everyday in the kitchen sink. We show that at small scales a circular hydraulic jump can be created in the absence of gravity by surface tension. The theory is motivated by our experimental finding of a height discontinuity in spreading submicron molten metal droplets created by pulsed-laser ablation. By careful control of initial conditions, this leads to solid femtoliter cups of gold, silver, copper, niobium, and tin.

  11. On the Spectral Gap of Brownian Motion with Jump Boundary

    CERN Document Server

    Kolb, Martin

    2011-01-01

    In this paper we consider the Brownian motion with jump boundary and present a new proof of a recent result of Li, Leung and Rakesh concerning the exact convergence rate in the one-dimensional case. Our methods are different and mainly probabilistic relying on coupling methods adapted to the special situation under investigation. Moreover, we answer a question raised by Ben-Ari and Pinsky concerning the dependence of the spectral gap on the jump distribution in a multi-dimensional setting.

  12. Forecasting Exchange Rate Volatility in the Presence of Jumps

    DEFF Research Database (Denmark)

    Busch, Thomas; Christensen, Bent Jesper; Nielsen, Morten Ørregaard

    of exchange rate futures options, allowingcalculation of option implied volatility. We find that implied volatility is an informationallyefficient but biased forecast of future realized exchange rate volatility. Furthermore,we show that log-normality is an even better distributional approximation...... for impliedvolatility than for realized volatility in this market. Finally, we show that the jump componentof future realized exchange rate volatility is to some extent predictable, and thatoption implied volatility is the dominant forecast of the future jump component....

  13. A drop jumps to weightlessness: a lecture demo

    Science.gov (United States)

    Mayer, V. V.; Varaksina, E. I.; Saranin, V. A.

    2017-04-01

    The paper discusses the lecture demonstration of the phenomenon in which a drop lying on a solid unwettable substrate jumps when making the transition to weightlessness. An elementary theory of the phenomenon is given. A jump speed estimate is obtained for small and large drops. The natural vibrational frequency of a flying drop is determined. A full-scale model of Einstein’s elevator is described. Experimental and theoretical results are found to agree satisfactorily.

  14. Importance sampling for jump processes and applications to finance

    OpenAIRE

    Badouraly Kassim, Laetitia; Lelong, Jérôme; Loumrhari, Imane

    2013-01-01

    International audience; Adaptive importance sampling techniques are widely known for the Gaussian setting of Brownian driven diffusions. In this work, we want to extend them to jump processes. Our approach relies on a change of the jump intensity combined with the standard exponential tilting for the Brownian motion. The free parameters of our framework are optimized using sample average approximation techniques. We illustrate the efficiency of our method on the valuation of financial derivat...

  15. Temperature Jump Pyrolysis Studies of RP 2 Fuel

    Science.gov (United States)

    2017-01-09

    Briefing Charts 3. DATES COVERED (From - To) 15 December 2016 – 11 January 2017 4. TITLE AND SUBTITLE Temperature Jump Pyrolysis Studies of RP-2 Fuel...Rev. 8- 98) Prescribed by ANSI Std. 239.18 1 TEMPERATURE JUMP PYROLYSIS STUDIES OF RP-2 FUEL Owen Pryor1, Steven D. Chambreau2, Ghanshyam L...Mixture Distribution A: Approved for public release; distribution unlimited. PA Clearance 17026 4 RP-2 Pyrolysis /Combustion Chemistries? • Recent

  16. Dynamic Jump Intensities and Risk Premiums in Crude Oil Futures and Options Markets

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Jacobs, Kris; Li, Bingxin

    2016-01-01

    and dynamic jump intensities in these markets. Allowing for jumps is crucial for modeling crude oil futures and futures options, and we find evidence in favor of time-varying jump intensities. During crisis periods, jumps occur more frequently. The properties of the jump processes implied by the option data......Options on crude oil futures are the most actively traded commodity options. We develop a class of computationally efficient discrete-time jump models that allow for closed-form option valuation, and we use crude oil futures and options data to investigate the economic importance of jumps...

  17. TEACHING GENDER AWARENESS THROUGH FAIRY TALES IN THE EFL CLASSROOM

    Directory of Open Access Journals (Sweden)

    Arisa Kochiyama

    2013-12-01

    Full Text Available The purpose of this study is to explore how gender has been portrayed historically and in current times in fairy tales and then to introduce the effectiveness of using fairy tales in language instruction. While some instructors may still believe that teaching EFL encompasses focusing on linguistic elements only, recent trend in EFL teaching indicates the necessity of integrating literature in the curricula because of its rich potential to provide an authentic model of language use as well as its universal themes within human history. Traditional fairy tales and modern ones can allow students to think critically about how men and women are portrayed and to compare these portrayals with their own communities. It is hoped that discussion of the topic of gender issues can help students foster critical thinking and literacy and empower them with a further understanding of gender notions in their lives.

  18. Creating a TALE protein with unbiased 5'-T binding.

    Science.gov (United States)

    Tsuji, Shogo; Futaki, Shiroh; Imanishi, Miki

    2013-11-01

    Transcription activator-like effectors (TALEs) are convenient tools for genome engineering at specific genomic sites. However, their use is constrained because most TALE binding sites are preceded by a highly conserved 5' terminal T nucleotide (5'-T). To remove the 5'-T constraint, we substituted tryptophan 232 in the repeat-1 loop region of the dHax3 N-terminal domain for other amino acids. Furthermore, we randomized four amino acid residues of the hairpin loop region of repeat-1. Although point mutation was insufficient to remove the 5'-T constraint, directed evolution from the randomized library yielded repeat-1 mutants with unbiased targeting sites for 5'-bases. Our result indicates that the repeat-1 loop region of dHax3 is important for 5'-base accommodation, and that molecular evolution of repeat-1 of TALEs is an efficient strategy to remove the 5'-T constraint and thus allow targeting of any DNA sequences.

  19. Electric-Field-Enhanced Jumping-Droplet Condensation

    Science.gov (United States)

    Miljkovic, Nenad; Preston, Daniel; Enright, Ryan; Limia, Alexander; Wang, Evelyn

    2013-11-01

    When condensed droplets coalesce on a superhydrophobic surface, the resulting droplet can jump due to the conversion of surface energy into kinetic energy. This frequent out-of-plane droplet jumping has the potential to enhance condensation heat and mass transfer. In this work, we demonstrated that these jumping droplets accumulate positive charge that can be used to further increase condensation heat transfer via electric fields. We studied droplet jumping dynamics on silanized nanostructured copper oxide surfaces. By characterizing the droplet trajectories under various applied external electric fields (0 - 50 V/cm), we show that condensation on superhydrophobic surfaces results in a buildup of negative surface charge (OH-) due to dissociated water ion adsorption on the superhydrophobic coating. Consequently, the opposite charge (H3O +) accumulates on the coalesced jumping droplet. Using this knowledge, we demonstrate electric-field-enhanced jumping droplet condensation whereby an external electric field opposes the droplet vapor flow entrainment towards the condensing surface to increase the droplet removal rate and overall surface heat transfer by 100% when compared to state-of-the-art dropwise condensing surfaces. This work not only shows significant condensation heat transfer enhancement through the passive charging of condensed droplets, but promises a low cost approach to increase efficiency for applications such as atmospheric water harvesting and dehumidification.

  20. Kinematic structure at the early flight position in ski jumping.

    Science.gov (United States)

    Vodičar, Janez; Coh, Milan; Jošt, Bojan

    2012-12-01

    The purpose of our research was to establish the variability of correlation between the length of the jumps and selected multi-item kinematic variables (n=9) in the early flight phase technique of ski jumping. This study was conducted on a sample of elite Slovenian ski jumpers (N=29) who participated in the experiment on a jumping hill in Hinterzarten, Germany (HS95m) on the 20(th) of August, 2008. The highest and most significant correlations (p=0.01) with the length of the ski jump were found in the multi-item variable height of flying, which was also expressed with the highest level of stability of the explained total variance (TV) on the first factor (TV=69.13%). The most important characteristic of the aerodynamic aspect of early flight was the variable angle between the body chord and the horizontal axis with significantly high correlations (pski and left leg (TV=50.13%), had an explained common variance on the first factor greater than 50% of total variance. The results indicated that some kinematic parameters of ski jumping early flight technique were more important for success considering the length of the jump.

  1. Kinetic asymmetries between forward and drop jump landing tasks

    Directory of Open Access Journals (Sweden)

    Morgana Alves de Britto

    2015-11-01

    Full Text Available Landing asymmetry is a risk factor for knee anterior cruciate ligament injury. The aim of this study was to identify kinetic asymmetries in healthy recreational athletes performing different jump-landing techniques. Twelve recreational athletes engaged in regular training underwent kinetic evaluation using two 3D force plates and were analyzed for: (a three-dimensional peak forces, (b time to peak vertical force, and (c initial phase asymmetries. All data were collected during performance of unilateral and bilateral trials of forward and drop jump tasks. Forward jump-landing tasks elicited greater kinetic asymmetry than drop-landing tasks. Regardless of jump-landing technique, the preferred leg experienced higher forces than the non-preferred leg. The initial landing phase showed more kinetic asymmetries than the later phase when peak vertical forces occur. It was concluded that when screening athletes for kinetic asymmetries that may predispose them to injury, forward jump-landing tasks and the early landing phase might show more kinetic asymmetries than drop jump-landing tasks and the late landing phase, respectively.

  2. The $k$-Tuple Jumping Champions among Consecutive Primes

    CERN Document Server

    Xiaosheng, Wu

    2011-01-01

    For any real $x$ and any integer $k\\ge1$, we say that a set $\\mathcal{D}_{k}$ of $k$ distinct integers is a $k$-tuple jumping champion if it is the most common differences that occurs among $k+1$ consecutive primes less than or equal to $x$. For $k=1$, it's known as the jumping champion introduced by J. H. Conway. In 1999 A. Odlyzko, M. Rubinstein, and M. Wolf announced the Jumping Champion Conjecture that the jumping champions greater than 1 are 4 and the primorials 2, 6, 30, 210, 2310,.... They also made a weaker and possibly more accessible conjecture that any fixed prime $p$ divides all sufficiently large jumping champions. These two conjectures were proved by Goldston and Ledoan under the assumption of appropriate forms of the Hardy-Littlewood conjecture recently. In the present paper we consider the situation for any $k\\ge2$ and prove that any fixed prime $p$ divides every element of all sufficiently large $k$-tuple jumping champions under the assumption that the Hardy-Littlewood prime $k+1$-tuple conje...

  3. MEASURE FOR MEASURE: A THRICE TOLD TALE

    Directory of Open Access Journals (Sweden)

    HALIMAH MOHAMED ALI

    2009-01-01

    Full Text Available This paper argues that Measure for Measure is a difficult play to perform because it has problematic themes, especially the theme of sexuality, that clash with the way of life and thinking of contemporary society. As such, any director who chooses to stage it must consider these difficulties and how to present them in a natural manner without making the audience feel that the whole production is contrived. The directors of the two major productions discussed in this paper tried their best to present a Measure for Measure that would be acceptable to the modern society. It is evident that there are many interpretations of the Duke and Isabella's characters and also of Isabella's reaction to the Duke's proposal at the end of the play. It can be concluded that no interpretation is wrong because each actor or director brings with him his own reading of the play, and every reading has been influenced by other performances and textual criticisms. Since Measure for Measure is a thematically rich play, it should not be confined to a single interpretation. The different performances of Measure for Measure have proven that theatre is experimental as well as ageless. Because it is a brilliant play with a myriad of interpretations, Measure for Measure will not cease to be a favourite for directors in times to come. It is not wrong to predict that fans of Shakespeare in general and of Measure for Measure in particular can look forward to many more productions.For experienced Shakespeare observers all performances are thrice-told tales. The perceiving eye absorbs the performance even as the mind's eye attends to the text. Both are augmented by the inner ear buzzing with those other voices, both critical and dramatic, carried by the observer into the theatre.(Crowl, Samuel 1992: 3

  4. A tale of two acute extradural hematomas

    Science.gov (United States)

    Adeleye, Amos Olufemi; Jite, Ikechi E.; Smith, Omolara A.

    2016-01-01

    Background: In much of the Western hemisphere, mortality from traumatic acute extradural hematomas (AEDH) has been drastically brought down toward 0%. This is still not the case however in most developing countries. Case Description: This report represents a tragi-comic tale of two cases of traumatic AEDH managed by an academic neurosurgeon in a neurosurgically ill-resourced private health facility during a nationwide industrial strike action preventing clinical-surgical care in the principal author's University Teaching Hospital. A young man presented with altered consciousness, Glasgow Coma Score (GCS) 14/15, following a road accident. The cranial computed tomography (CT) scan was obtained only 9 h after its request, long after the man had actually deteriorated to GCS 7/15 with pupillary changes. The neurosurgeon, summoned from the nearby University Teaching Hospital for the operative care of this man, arrived on-site and was about moving the patient into the operative room when he took the final breaths and died, all within 2 h of the belated neuroimaging. This scenario repeated itself in the same health facility just 24 h later with another young man who presented GCS 7/15 and another identical CT evidence of traumatic AEDH. With more financially able relations, the diagnostic/surgical care of this second patient was much more prompt. He made a very brisk recovery from neurosurgical operative intervention. He is alive and well, 5-month postoperative. Conclusions: In most low-resourced health systems of the developing countries, a significant proportion of potentially salvageable cases of AEDH still perish from this disease condition. PMID:27213108

  5. Can jumping capacity of adult show jumping horses be predicted on the basis of submaximal free jumps at foal age? A longitudinal study.

    Science.gov (United States)

    Bobbert, Maarten F; Santamaría, Susana; van Weeren, P René; Back, Wim; Barneveld, Albert

    2005-09-01

    The purpose of this study was to quantify performance characteristics of good jumping horses, and to determine whether these were already detectable at foal age. Kinematic data were collected of horses performing free jumps over a 0.60 m high fence at six months of age and of these same horses jumping with a rider over a 1.15 m high fence at five years of age. At five years of age the horses were divided into three groups on the basis of a puissance competition: a group of seven best jumpers that made no errors and in the end cleared a 1.50 m high fence, a group of nine worst jumpers that were unable to clear a 1.40 m high fence, and an intermediate group of 13 horses. Longitudinal kinematic data was available for all seven best jumpers and for six of the nine worst jumpers. Average values of variables for the best jumpers were compared with those of the worst jumpers for the jumps over 1.15 m. In the group of best jumpers, the forelimbs were shorter at forelimb clearance due to increased elbow flexion, and the hind limbs were further retroflexed at hind limb clearance. The same superior technique in clearing fences with the limbs was also found in this group at six months of age. Nevertheless, for individual horses it turned out to be too far-fetched to predict adult jumping capacity on the basis of kinematic variables collected during submaximal jumps at foal age.

  6. Closed loop statistical performance analysis of N-K knock controllers

    Science.gov (United States)

    Peyton Jones, James C.; Shayestehmanesh, Saeed; Frey, Jesse

    2017-09-01

    The closed loop performance of engine knock controllers cannot be rigorously assessed from single experiments or simulations because knock behaves as a random process and therefore the response belongs to a random distribution also. In this work a new method is proposed for computing the distributions and expected values of the closed loop response, both in steady state and in response to disturbances. The method takes as its input the control law, and the knock propensity characteristic of the engine which is mapped from open loop steady state tests. The method is applicable to the 'n-k' class of knock controllers in which the control action is a function only of the number of cycles n since the last control move, and the number k of knock events that have occurred in this time. A Cumulative Summation (CumSum) based controller falls within this category, and the method is used to investigate the performance of the controller in a deeper and more rigorous way than has previously been possible. The results are validated using onerous Monte Carlo simulations, which confirm both the validity of the method and its high computational efficiency.

  7. IdealKnock: A framework for efficiently identifying knockout strategies leading to targeted overproduction.

    Science.gov (United States)

    Gu, Deqing; Zhang, Cheng; Zhou, Shengguo; Wei, Liujing; Hua, Qiang

    2016-04-01

    In recent years, computer aided redesigning methods based on genome-scale metabolic network models (GEMs) have played important roles in metabolic engineering studies; however, most of these methods are hindered by intractable computing times. In particular, methods that predict knockout strategies leading to overproduction of desired biochemical are generally unable to do high level prediction because the computational time will increase exponentially. In this study, we propose a new framework named IdealKnock, which is able to efficiently evaluate potentials of the production for different biochemical in a system by merely knocking out pathways. In addition, it is also capable of searching knockout strategies when combined with the OptKnock or OptGene framework. Furthermore, unlike other methods, IdealKnock suggests a series of mutants with targeted overproduction, which enables researchers to select the one of greatest interest for experimental validation. By testing the overproduction of a large number of native metabolites, IdealKnock showed its advantage in successfully breaking through the limitation of maximum knockout number in reasonable time and suggesting knockout strategies with better performance than other methods. In addition, gene-reaction relationship is well considered in the proposed framework.

  8. Structural-Parameter-Based Jumping-Height-and-Distance Adjustment and Obstacle Sensing of a Bio-Inspired Jumping Robot

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    2015-06-01

    Full Text Available Jumping-height-and-distance (JHD active adjustment capability is important for jumping robots to overcome different sizes of obstacle. This paper proposes a new structural parameter-based JHD active adjustment approach for our previous jumping robot. First, the JHD adjustments, modifying the lengths of different legs of the robot, are modelled and simulated. Then, three mechanisms for leg-length adjustment are proposed and compared, and the screw-and-nut mechanism is selected. And for adjusting of different structural parameters using this mechanism, the one with the best JHD adjusting performance and the lowest mechanical complexity is adopted. Thirdly, an obstacle-distance-and-height (ODH detection method using only one infrared sensor is designed. Finally, the performances of the proposed methods are tested. Experimental results show that the jumping-height-and distance adjustable ranges are 0.11 m and 0.96 m, respectively, which validates the effectiveness of the proposed JHD adjustment method.

  9. Student Teachers’ Perceptions of Success: A Tale of Two Universities

    Directory of Open Access Journals (Sweden)

    Mark Hirschkorn

    2012-01-01

    Full Text Available This article is primarily focused on a recent group (tale 2 experiencing a seriesof embedded and interactive field based experiences (field learning; thediscussion is benchmarked to a previous study (tale 1 of student teachershaving had a more traditional semester practicum as part of their field-basedexperience. It is within this context that the authors’ show support for rarelynoted findings (knowledge supporting the efficacy of university campus programs:novice teachers linking their success in field-based teaching to theiruniversity campus program (campus learning. We contend this is importantevidence supporting the link between theory and practice that has the potentialto better inform educational management decisions.

  10. Lyd på museum 2: Fairy Tales Forever

    DEFF Research Database (Denmark)

    Lønstrup, Ansa

    2005-01-01

    Artiklen belyser det, at værker med lyd installeres i kunstmuseer, her flere kunstneres værker fra HCA-udstillingen på kunstmuseet ARoS, "Fairy Tales Forever". Om flg. kunstnere: Pipilotti Rist, Tabaimo, William Kentridge, Tony Ousler. Udgivelsesdato: 14.12.05......Artiklen belyser det, at værker med lyd installeres i kunstmuseer, her flere kunstneres værker fra HCA-udstillingen på kunstmuseet ARoS, "Fairy Tales Forever". Om flg. kunstnere: Pipilotti Rist, Tabaimo, William Kentridge, Tony Ousler. Udgivelsesdato: 14.12.05...

  11. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Directory of Open Access Journals (Sweden)

    Daniel A Felix

    2010-04-01

    Full Text Available Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is

  12. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Science.gov (United States)

    Felix, Daniel A; Aboobaker, A Aziz

    2010-04-22

    Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi) animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation) to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is required for

  13. Estimation of knock acoustical signal by parametric inversion method; Estimation du signal acoustique de cliquetis par inversion parametrique

    Energy Technology Data Exchange (ETDEWEB)

    Boubal, O.; Oksman, J. [Ecole Superieure d' Electricite, 91 - Gif-sur-Yvette (France)

    1999-07-01

    Knock on spark ignition engines goes against car manufacturers efforts to reduce fuel consumption and exhaust gas emissions. This article develops a signal processing method to quantify knock. After discussing some classical techniques of knock energy estimation, an acoustical measurement technique is presented. An original signal processing method based on a parametric behavioral model for both knock and apparatus and a special inversion technique are used to get actual knock parameters. The knock related parameters are computed in a two step process. A deconvolution algorithm is used to obtain a signal made of unitary pulses, followed by an efficient inversion method. The whole process is applied to real data from a one-cylinder engine. Moreover, the results are compared to those obtained from an existing technique to suit a common industrial application. (authors)

  14. A comparison of pairs figure skaters in repeated jumps.

    Science.gov (United States)

    Sands, William A; Kimmel, Wendy L; McNeal, Jeni R; Murray, Steven Ross; Stone, Michael H

    2012-01-01

    Trends in pairs figure skating have shown that increasingly difficult jumps have become an essential aspect of high-level performance, especially in the latter part of a competitive program. We compared a repeated jump power index in a 60 s repeated jump test to determine the relationship of repeated jump test to competitive rank and to measure 2D hip, knee, and ankle angles and angular velocities at 0, 20, 40, and 60 s. Eighteen National Team Pairs Figure Skaters performed a 60 s repeated jump test on a large switch-mat with timing of flight and ground durations and digital video recording. Each 60-s period was divided into 6, 10-s intervals, with power indexes (W/kg) calculated for each 10-s interval. Power index by 10-s interval repeated measures ANOVAs (RMANOVA) showed that males exceeded females at all intervals, and the highest power index interval was during 10 to 20 s for both sexes. RMANOVAs of angles and angular velocities showed main effects for time only. Power index and jumping techniques among figure skaters showed rapid and steady declines over the test duration. Power index can predict approximately 50% of competitive rank variance, and sex differences in jumping technique were rare. Key pointsThe repeated jumps test can account for about 50% of the variance in pairs ranks.Changes in technique are largely due to fatigue, but the athletes were able to maintain a maximum flexion knee angle very close to the desired 90 degrees. Changes in angular velocity and jump heights occurred as expected, again probably due to fatigue.As expected from metabolic information, the athletes' power indexes peak around 20s and decline thereafter. Coaches should be aware of this time as a boundary beyond which fatigue becomes more manifest, and use careful choreographic choices to provide rest periods that are disguised as less demanding skating elements to afford recovery.The repeated jumps test may be a helpful off-ice test of power-endurance for figure skaters.

  15. Structural Analysis of Shahe Siyahpushan Tale Based on Propp’s Model

    Directory of Open Access Journals (Sweden)

    F Neghabi

    2012-09-01

    Full Text Available Nezami's Haftpeykar is one of the beautiful tales of lyrical verse that has many similarities to fairy tales from structuralist viewpoint. The authors analyze structural similarities and differences based on dutifulnesses, their interaction and dichotomy, fixed or variable characters and the logical sequence of narrative structure. The results demonstrate that this tale conforms to Propp's model and also narrative structure of fairy tales because shahe siyahpushan consists of about twenty dutifulnesses out of thirty-one dutifulnesses of fairy tales and the order and sequence of the story is the same as Propp’s model. The order and sequence of the whole narrative is based on opposition.

  16. High-temperature expansion and knock-out properties of moulding sands with water glass

    Directory of Open Access Journals (Sweden)

    Major-Gabryś K.

    2007-01-01

    Full Text Available The article focuses on the topic of improving the knock-out properties of moulding sand with water glass and ester hardener. It is settled that the cause of worse knock-out properties of moulding sand can be brought by their thermal expansion in increased temperatures. There is a presentation of the influence of different additives, containing Al2O3, on moulding sands’ expansion in increased temperatures. Within the frames of research, there was an elaboration of the influence of authors own additive- Glassex, on the expansion phenomenon of moulding sands with water glass and ester hardener. It is concluded, that the new additive stops the expansion of moulding sands and as well it improves their knock-out properties.

  17. Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive

    Science.gov (United States)

    Williams, Michael R.; DeSpenza, Tyrone; Li, Meijie; Gulledge, Allan T.

    2015-01-01

    Developing neurons must regulate morphology, intrinsic excitability, and synaptogenesis to form neural circuits. When these processes go awry, disorders, including autism spectrum disorder (ASD) or epilepsy, may result. The phosphatase Pten is mutated in some patients having ASD and seizures, suggesting that its mutation disrupts neurological function in part through increasing neuronal activity. Supporting this idea, neuronal knock-out of Pten in mice can cause macrocephaly, behavioral changes similar to ASD, and seizures. However, the mechanisms through which excitability is enhanced following Pten depletion are unclear. Previous studies have separately shown that Pten-depleted neurons can drive seizures, receive elevated excitatory synaptic input, and have abnormal dendrites. We therefore tested the hypothesis that developing Pten-depleted neurons are hyperactive due to increased excitatory synaptogenesis using electrophysiology, calcium imaging, morphological analyses, and modeling. This was accomplished by coinjecting retroviruses to either “birthdate” or birthdate and knock-out Pten in granule neurons of the murine neonatal dentate gyrus. We found that Pten knock-out neurons, despite a rapid onset of hypertrophy, were more active in vivo. Pten knock-out neurons fired at more hyperpolarized membrane potentials, displayed greater peak spike rates, and were more sensitive to depolarizing synaptic input. The increased sensitivity of Pten knock-out neurons was due, in part, to a higher density of synapses located more proximal to the soma. We determined that increased synaptic drive was sufficient to drive hypertrophic Pten knock-out neurons beyond their altered action potential threshold. Thus, our work contributes a developmental mechanism for the increased activity of Pten-depleted neurons. PMID:25609613

  18. Effect of Instructions on Selected Jump Squat Variables.

    Science.gov (United States)

    Talpey, Scott W; Young, Warren B; Beseler, Bradley

    2016-09-01

    Talpey, SW, Young, WB, and Beseler, B. Effect of instructions on selected jump squat variables. J Strength Cond Res 30(9): 2508-2513, 2016-The purpose of this study was to compare 2 instructions on the performance of selected variables in a jump squat (JS) exercise. The second purpose was to determine the relationships between JS variables and sprint performance. Eighteen male subjects with resistance training experience performed 2 sets of 4 JS with no extra load with the instructions to concentrate on (a) jumping for maximum height and (b) extending the legs as fast as possible to maximize explosive force. Sprint performance was assessed at 0- to 10-m and 10- to 20-m distances. From the JS jump height, peak power, relative peak power, peak force, peak velocity, and countermovement distance were measured from a force platform and position transducer system. The JS variables under the 2 instructions were compared with paired t-tests, and the relationships between these variables and sprint performance were determined with Pearson's correlations. The jump height instruction produced greater mean jump height and peak velocity (p 0.05). Jump height was the variable that correlated most strongly with 10-m time and 10- to 20-m time under both instructions. The height instruction produced a stronger correlation with 10-m time (r = -0.455), but the fast leg extension JS produced a greater correlation with 10-20 time (r = -0.545). The results indicate that instructions have a meaningful influence on JS variables and therefore need to be taken into consideration when assessing or training athletes.

  19. Scaling and jumping: gravity loses grip on small jumpers.

    Science.gov (United States)

    Scholz, Melanie N; Bobbert, Maarten F; Knoek van Soest, A J

    2006-06-21

    There are several ways to quantify jumping performance, a common definition being the height gained by the body's centre of mass (CM) in the airborne phase. Under this definition, jump height is determined by take-off velocity. According to the existing literature on jumping and scaling, take-off velocity, and hence jumping performance is independent of size because the energy that differently sized geometrically scaled jumpers can generate with their muscles is proportional to their mass. In this article it is shown, based on a simple energy balance, that it is incorrect to presume that jump height does not depend on size. Contrary to common belief, size as such has does have an effect on take-off velocity, putting small jumpers at a mechanical advantage, as is shown analytically. To quantify the effect of size on take-off velocity, a generic jumper model was scaled geometrically and evaluated numerically. While a 70-kg jumper took off at 2.65 m/s and raised its CM by 0.36 m after take-off, a perfectly geometrically similar jumper of 0.7 g reached a take-off velocity of 3.46 m/s and raised its CM by 0.61 m. The reason for the better performance of small jumpers is their higher efficacy in transforming the energy generated by the actuators into energy due to vertical velocity of the CM. Considering the ecological and evolutionary relevance of different definitions of jump height, size-dependent efficacy might explain why habitual jumping is especially prominent among small animals such as insects.

  20. Isokinetic knee extension and vertical jumping: are they related?

    Science.gov (United States)

    Iossifidou, Anna; Baltzopoulos, Vasilios; Giakas, Giannis

    2005-10-01

    The aim of this study was to examine joint power generation during a concentric knee extension isokinetic test and a squat vertical jump. The isokinetic test joint power was calculated using four different methods. Five participants performed concentric knee extensions at 0.52, 1.57, 3.14 and 5.23 rad x s(-1) on a Lido isokinetic dynamometer. The squat vertical jump was performed on a Kistler force plate. Kinematic data from both tests were collected and analysed using an ELITE optoelectronic system. An inverse dynamics model was applied to measure knee joint moment in the vertical jump. Knee angular position data from the kinematic analysis in the isokinetic test were used to derive the actual knee angular velocity and acceleration, which, in turn, was used to correct the dynamometer moment for inertial effects. Power was measured as the product of angular velocity and moment at the knee joint in both tests. Significant differences (P knee joint power in the two tests (squat vertical jump: 2255 +/- 434 W; isokinetic knee extension: 771 +/- 81 W). Correlation analysis revealed that there is no relationship between the peak knee joint power during the vertical jump and the slow velocity isokinetic tests. Higher isokinetic velocity tests show better relationships with the vertical jump but only if the correct method for joint power calculation is used in the isokinetic test. These findings suggest that there are important differences in muscle activation and knee joint power development that must be taken into consideration when isokinetic tests are used to predict jumping performance.

  1. Magic Fairy Tales as Source for Interface Metaphors

    CERN Document Server

    Averbukh, Vladimir L

    2008-01-01

    The work is devoted to a problem of search of metaphors for interactive systems and systems based on Virtual Reality (VR) environments. The analysis of magic fairy tales as a source of metaphors for interface and virtual reality is offered. Some results of design process based on magic metaphors are considered.

  2. Construct Validation of the Fairy Tale Test--Standardization Data.

    Science.gov (United States)

    Coulacoglou, Carina

    2002-01-01

    Studied the construct validity of the Fairy Tale Test (C. Coulacoglu, 1993), a personality projective test for children, in a sample of 800 Greek children aged 8, 10, and 12. Factor analysis led to identification of eight primary factors, and correlations with other measures provide construct validity evidence. (SLD)

  3. Shamans and Kushtakas: North Coast Tales of the Supernatural.

    Science.gov (United States)

    Beck, Mary Giraudo

    The Tlingit and Haida are Native Americans who inhabit southeast Alaska and share many traditions and stories. Written by a non-native scholar, this book contains nine Tlingit and Haida tales concerned with shamans and kushtakas. Land otters were fearful hybrid beings of the spirit world. Able to live on land and in water, they had the special…

  4. Indian Tales of the Northern Rockies. Indian Culture Series.

    Science.gov (United States)

    Old Coyote, Sally; Toineeta, Joy Yellowtail

    Part of the Montana Council for Indian Education's Indian Culture Series, the book contains six folk stories recorded on reservations and by headstart teachers. The stories are: "The Owl", a Gros Ventre tale; "How the Robin Got a Red Breast", from the Flathead Tribe; "Old Man Coyote and the Wild Geese", a Crow Indian…

  5. Libraries of Synthetic TALE-Activated Promoters: Methods and Applications.

    Science.gov (United States)

    Schreiber, T; Tissier, A

    2016-01-01

    The discovery of proteins with programmable DNA-binding specificities triggered a whole array of applications in synthetic biology, including genome editing, regulation of transcription, and epigenetic modifications. Among those, transcription activator-like effectors (TALEs) due to their natural function as transcription regulators, are especially well-suited for the development of orthogonal systems for the control of gene expression. We describe here the construction and testing of libraries of synthetic TALE-activated promoters which are under the control of a single TALE with a given DNA-binding specificity. These libraries consist of a fixed DNA-binding element for the TALE, a TATA box, and variable sequences of 19 bases upstream and 43 bases downstream of the DNA-binding element. These libraries were cloned using a Golden Gate cloning strategy making them usable as standard parts in a modular cloning system. The broad range of promoter activities detected and the versatility of these promoter libraries make them valuable tools for applications in the fine-tuning of expression in metabolic engineering projects or in the design and implementation of regulatory circuits.

  6. The Lobster Tale: An Exercise in Critical Thinking

    Science.gov (United States)

    Stepanovich, Paul L.

    2009-01-01

    Professors in management and business are encouraged to incorporate critical thinking as an objective in their courses. "The Lobster Tale" provides an opportunity to engage students in various levels of critical thinking, ranging from a relatively superficial reading to an examination of the deeper, often hidden issues. Using the foundations of…

  7. Computational Drafting of Plot Structures for Russian Folk Tales.

    Science.gov (United States)

    Gervás, Pablo

    The plots of stories are known to follow general patterns in terms of their overall structure. This was the basic tenet of structuralist approaches to narratology. Vladimir Propp proposed a procedure for the generation of new tales based on his semi-formal description of the structure of Russian folk tales. This is one of the first existing instances of a creative process described procedurally. The present paper revisits Propp's morphology to build a system that generates instances of Russian folk tales. Propp's view of the folk tale as a rigid sequence of character functions is employed as a plot driver, and some issues that Propp declared relevant but did not explore in detail-such as long-range dependencies between functions or the importance of endings-are given computational shape in the context of a broader architecture that captures all the aspects discussed by Propp. A set of simple evaluation metrics for the resulting outputs is defined inspired on Propp's formalism. The potential of the resulting system for providing a creative story generation system is discussed, and possible lines of future work are discussed.

  8. Control of plant architecture by distinctive TALE homeobox gene interactions

    NARCIS (Netherlands)

    Bao, D.

    2009-01-01

    In eukaryotes, transcription factor (TF)-based network is a widely used mechanism to regulate fundamental developmental processes. Both animals and plants utilize three-amino-acid-loop-extension (TALE) homeodomain (HD) transcription factors to subdivide their body plan. In animals, MEIS/PBC TF heter

  9. A Folk Tale of a Man Who Saves Three Animals

    OpenAIRE

    Zla ba sgrol ma

    2009-01-01

    This folk tale relates how a young man saves three animals – a mouse, a bear, and a monkey – who later repay their debt of gratitude to him This collection presents forty-nine audio files including: several folk song genres; folktales and; local history from the Sman shad Valley of Sde dge County World Oral Literature Project

  10. Fairy-tale planet: creative science writing for children

    Science.gov (United States)

    Lanza, Tiziana; D'Addezio, Giuliana

    2017-04-01

    During public events organized by our Institute sometimes we have predisposed a corner to entertain primary school children with fairy-tales about the planet. In that occasion we realized that even if children could take part in other activities more in fashion such as laboratories, theatre performances, exhibits, they were very attracted by fairy tales, such an "ancient" tradition. This year within the projects "alternanza scuola-lavoro" we are planning to involve also the students of the secondary schools to learn themselves how to animate a fairy-tale corner for children. The "alternanza scuola lavoro" (interchange school/work) has been recently introduced in the Italian school as a methodology for implementing the second cycle teaching. The general purpose is to ensure that 15 to 18 years old students, beside the access to basic knowledge, can acquire skills in the employment and real work environments experiencing other teaching methods based both on knowledge and know-how. We will then start a new adventure by investigating what will be the best way to introduce children to creative science writing for the planet. The aim would be that of creating a format suitable for children either for writing all together a planet fairy-tale in class, or individually. The final goal is to raise awareness about the environmental problems by stimulating in scholars their own creativity.

  11. The Structural-Communicative Pattern of Hadiqa's Tales

    Directory of Open Access Journals (Sweden)

    B Mirzaei

    2011-04-01

    The analysis of the addresser, addressee and context elements and their functions in Hadiqa’s tales indicates that the referential function is the most significant and dominant function in this work and so communication orients towards context .Then the conative and emotive functions are dominant and reinforce the effect of narrator’s speech.

  12. The Cosmic Rays Energy Spectrum observed by the TALE detector

    Science.gov (United States)

    Abuzayyad, Tareq; Telescope Array Collaboration Collaboration

    2016-03-01

    We report on a cosmic ray energy spectrum measurement by the Telescope Array Low-Energy extension (TALE) fluorescence detector (FD). The TALE FD is an air fluorescence detector which is also sensitive to the Cerenkov light produced by shower particles. Low energy cosmic rays, in the PeV energy range, are detectable by TALE as ``Cerenkov Events''. Using these events, we measure the energy spectrum from a low energy of 4 PeV to an energy greater than 100 PeV. Starting at around 100 PeV, TALE also observes showers by their fluorescence light; and above this energy fluorescence becomes the dominant light production mechanism by which most showers are observed. The event processing and reconstruction procedures are identical for both low and high energy regions. This allows for treating the Cherenkov events and Fluorescence events as a single data set and thus calculating a single cosmic rays energy spectrum based on this data set, which extends from an energy of 4 PeV to above 1 EeV. In this talk, we will describe the detector, explain the technique, and present results from the measurement of the spectrum in this energy range by the Telescope Array experiment.

  13. The validity and reliability of an iPhone app for measuring vertical jump performance.

    Science.gov (United States)

    Balsalobre-Fernández, Carlos; Glaister, Mark; Lockey, Richard Anthony

    2015-01-01

    The purpose of this investigation was to analyse the concurrent validity and reliability of an iPhone app (called: My Jump) for measuring vertical jump performance. Twenty recreationally active healthy men (age: 22.1 ± 3.6 years) completed five maximal countermovement jumps, which were evaluated using a force platform (time in the air method) and a specially designed iPhone app. My jump was developed to calculate the jump height from flight time using the high-speed video recording facility on the iPhone 5 s. Jump heights of the 100 jumps measured, for both devices, were compared using the intraclass correlation coefficient, Pearson product moment correlation coefficient (r), Cronbach's alpha (α), coefficient of variation and Bland-Altman plots. There was almost perfect agreement between the force platform and My Jump for the countermovement jump height (intraclass correlation coefficient = 0.997, P iPhone 5 s app.

  14. The acute effect of vibration applications on jumping performance

    Directory of Open Access Journals (Sweden)

    Suat Yıldız

    2012-12-01

    Full Text Available Recently, vibration has become very popular as a method of exercise and training and drawn attention of researchers. The aim of this study was to analyses the acute affect of vibration applications as a method of exercise and training on jumping performance.In this study experimental group consists of 25 subjects who are studying at Physical Education and Sports Department of Sakarya University (age 22.2±1.7 years, height 179.2±4.8 cm. body weight 71.5±9.0 kg. This study included a vibration at density of 35 Hz (3x30 sec. frequency that result from aerobic exercise that has low density and b just methods of aerobic exercise (without any vibration that has low density. Subjects have taken the tests of countermovement and squat jumping after 2 minutes of each application. All applications and tests have been done in nonconsecutive days in a random scheme. In statistical analysis Wilcoxon has been applied in nonparametric scheme.For counter movement jumping; height of jumping, the difference between before and after the application of vibration related to the point of peak power and average power has been found significiant (respectively, p0.05; p>0.05; p>0.05.As a result, it is concluded that vibration that is applied at the range of 35 Hz frequency could increase the performance of acute countermovement jumping.

  15. Mechanical parameters and flight phase characteristics in aquatic plyometric jumping.

    Science.gov (United States)

    Louder, Talin J; Searle, Cade J; Bressel, Eadric

    2016-09-01

    Plyometric jumping is a commonly prescribed method of training focused on the development of reactive strength and high-velocity concentric power. Literature suggests that aquatic plyometric training may be a low-impact, effective supplement to land-based training. The purpose of the present study was to quantify acute, biomechanical characteristics of the take-off and flight phase for plyometric movements performed in the water. Kinetic force platform data from 12 young, male adults were collected for counter-movement jumps performed on land and in water at two different immersion depths. The specificity of jumps between environmental conditions was assessed using kinetic measures, temporal characteristics, and an assessment of the statistical relationship between take-off velocity and time in the air. Greater peak mechanical power was observed for jumps performed in the water, and was influenced by immersion depth. Additionally, the data suggest that, in the water, the statistical relationship between take-off velocity and time in air is quadratic. Results highlight the potential application of aquatic plyometric training as a cross-training tool for improving mechanical power and suggest that water immersion depth and fluid drag play key roles in the specificity of the take-off phase for jumping movements performed in the water.

  16. Jump point detection for real estate investment success

    Science.gov (United States)

    Hui, Eddie C. M.; Yu, Carisa K. W.; Ip, Wai-Cheung

    2010-03-01

    In the literature, studies on real estate market were mainly concentrating on the relation between property price and some key factors. The trend of the real estate market is a major concern. It is believed that changes in trend are signified by some jump points in the property price series. Identifying such jump points reveals important findings that enable policy-makers to look forward. However, not all jump points are observable from the plot of the series. This paper looks into the trend and introduces a new approach to the framework for real estate investment success. The main purpose of this paper is to detect jump points in the time series of some housing price indices and stock price index in Hong Kong by applying the wavelet analysis. The detected jump points reflect to some significant political issues and economic collapse. Moreover, the relations among properties of different classes and between stocks and properties are examined. It can be shown from the empirical result that a lead-lag effect happened between the prices of large-size property and those of small/medium-size property. However, there is no apparent relation or consistent lead in terms of change point measure between property price and stock price. This may be due to the fact that globalization effect has more impact on the stock price than the property price.

  17. Unilateral jump behavior in young professional female ballet dancers.

    Science.gov (United States)

    Golomer, E; Féry, Y A

    2001-09-01

    In the field of dance, lateral body actions should be differently influenced by training. Classes should develop symmetrical jump behavior by the alternate working of the two body sides. In contrast, asymmetrical training effect linked to hemispheric laterality should be also expected. Indeed, for aesthetic reasons, the preferred led has to give the jump direction while the other leg has to carry out the impulsion during take-off. In addition, and for functional reasons, the preferred leg also has to ensure a soft landing and to avoid imbalance upon landing. To address the question, we studied ten professional right-footed female ballet dancers in a unilateral experimental task: the maximal vertical jump (MVJ). The MVJ height was compared for each leg in ten trials. In addition, the side of the leg usually involved in a choreographic bilateral task was determined. All these right-footed dancers selected their left leg as the impulsion leg for the choreographic jump so as to reserve the right leg for the expression of the artistic gesture linked to emotional laterality. However, ANOVA did not show differences between the right and left legs in MVJ. In these young ballerinas, jump actions of the two body sides seem to develop symmetrically by class training effects.

  18. Volatility Forecasting: Downside Risk, Jumps and Leverage Effect

    Directory of Open Access Journals (Sweden)

    Francesco Audrino

    2016-02-01

    Full Text Available We provide empirical evidence of volatility forecasting in relation to asymmetries present in the dynamics of both return and volatility processes. Using recently-developed methodologies to detect jumps from high frequency price data, we estimate the size of positive and negative jumps and propose a methodology to estimate the size of jumps in the quadratic variation. The leverage effect is separated into continuous and discontinuous effects, and past volatility is separated into “good” and “bad”, as well as into continuous and discontinuous risks. Using a long history of the S & P500 price index, we find that the continuous leverage effect lasts about one week, while the discontinuous leverage effect disappears after one day. “Good” and “bad” continuous risks both characterize the volatility persistence, while “bad” jump risk is much more informative than “good” jump risk in forecasting future volatility. The volatility forecasting model proposed is able to capture many empirical stylized facts while still remaining parsimonious in terms of the number of parameters to be estimated.

  19. CONNECTION OF FUNCTIONAL ABILITIES WITH JUMPING AND THROWING ATHLETIC DISCIPLINES

    Directory of Open Access Journals (Sweden)

    Igor Stanojević

    2014-06-01

    Full Text Available The aim of this study was to determine the connection between functional abilities with results of jumping and throwing athletic disciplines with athletes. The sample was taken from a population of elementary school students from Prokuplje region, 13 and 14 old, included in regular physical education classes. The sample consisted of 200 male athletes involved in the training process in sports clubs at least three times a week in addition to physical education classes. For assessment of functional abilities six functional tests were used: resting heart rate, Cooper test, heart rate in the first minute after Cooper test, heart rate in the second minute after Cooper test, systolic arterial blood pressure, diastolic arterial blood pressure. For assessment of jumping and throwing athletic disciplines four tests were used: long jump, high jump, shot put and javelin. Data analysis was performed with canonical correlation and regression analysis. The results showed a statistically significant correlation between functional abilities with all of tests in jumping and throwing athletic disciplines.

  20. Biological Jumping Mechanism Analysis and Modeling for Frog Robot

    Institute of Scientific and Technical Information of China (English)

    Meng Wang; Xi-zhe Zang; Ji-zhuang Fan; Jie Zhao

    2008-01-01

    This paper presents a mechanical model of jumping robot based on the biological mechanism analysis of frog. By biological observation and kinematic analysis the frog jump is divided into take-off phase, aerial phase and landing phase. We find the similar trajectories of hindlimb joints during jump, the important effect of foot during take-off and the role of forelimb in supporting the body. Based on the observation, the frog jump is simplified and a mechanical model is put forward. The robot leg is represented by a 4-bar spring/linkage mechanism model, which has three Degrees of Freedom (DOF) at hip joint and one DOF (passive) at tarsometatarsal joint on the foot. The shoulder and elbow joints each has one DOF for the balancing function of arm.The ground reaction force of the model is analyzed and compared with that of frog during take-off. The results show that the model has the same advantages of low likelihood of premature lift-off and high efficiency as the frog. Analysis results and the model can be employed to develop and control a robot capable of mimicking the jumping behavior of flog.

  1. Vertical jumping tests in volleyball: reliability, validity, and playing-position specifics.

    Science.gov (United States)

    Sattler, Tine; Sekulic, Damir; Hadzic, Vedran; Uljevic, Ognjen; Dervisevic, Edvin

    2012-06-01

    Vertical jumping is known to be important in volleyball, and jumping performance tests are frequently studied for their reliability and validity. However, most studies concerning jumping in volleyball have dealt with standard rather than sport-specific jumping procedures and tests. The aims of this study, therefore, were (a) to determine the reliability and factorial validity of 2 volleyball-specific jumping tests, the block jump (BJ) test and the attack jump (AJ) test, relative to 2 frequently used and systematically validated jumping tests, the countermovement jump test and the squat jump test and (b) to establish volleyball position-specific differences in the jumping tests and simple anthropometric indices (body height [BH], body weight, and body mass index [BMI]). The BJ was performed from a defensive volleyball position, with the hands positioned in front of the chest. During an AJ, the players used a 2- to 3-step approach and performed a drop jump with an arm swing followed by a quick vertical jump. A total of 95 high-level volleyball players (all men) participated in this study. The reliability of the jumping tests ranged from 0.97 to 0.99 for Cronbach's alpha coefficients, from 0.93 to 0.97 for interitem correlation coefficients and from 2.1 to 2.8 for coefficients of variation. The highest reliability was found for the specific jumping tests. The factor analysis extracted one significant component, and all of the tests were highly intercorrelated. The analysis of variance with post hoc analysis showed significant differences between 5 playing positions in some of the jumping tests. In general, receivers had a greater jumping capacity, followed by libero players. The differences in jumping capacities should be emphasized vis-a-vis differences in the anthropometric measures of players, where middle hitters had higher BH and body weight, followed by opposite hitters and receivers, with no differences in the BMI between positions.

  2. A NEW METHOD FOR CHARACTERIZING THE KNOCK RESISTANCE OF LNG FUELS USED IN THE TRANSPORTATION MARKET

    NARCIS (Netherlands)

    Levinsky, Howard; Gersen, Sander; van Essen, Martijn; van Dijk, Gerco

    2014-01-01

    To ensure that the engines to be used in LNG-fueled vehicles are matched with the expected variations in fuel composition, the knock resistance of the fuel must be determined unambiguously. Rather than rely on empirical methods using gas mixtures and “standard” engines traditionally employed for thi

  3. CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons.

    Directory of Open Access Journals (Sweden)

    Christoph Straub

    Full Text Available The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual cells, effectively resulting in knock-out of targeted genes. It thus promises to be an ideal candidate for application in neuroscience where constitutive genetic modifications are frequently either lethal or ineffective due to adaptive changes of the brain. Here we use CRISPR/Cas9 to knock-out Grin1, the gene encoding the obligatory NMDA receptor subunit protein GluN1, in a sparse population of mouse pyramidal neurons. Within this genetically mosaic tissue, manipulated cells lack synaptic current mediated by NMDA-type glutamate receptors consistent with complete knock-out of the targeted gene. Our results show the first proof-of-principle demonstration of CRISPR/Cas9-mediated knock-down in neurons in vivo, where it can be a useful tool to study the function of specific proteins in neuronal circuits.

  4. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish.

    Science.gov (United States)

    Liu, Yuan; Chen, Xue; Qin, Bing; Zhao, Kanxing; Zhao, Qingshun; Staley, Jonathan P; Zhao, Chen

    2015-01-01

    Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene is a fundamental component for precursor message RNA (pre-mRNA) splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP). This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO) aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs) components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  5. Developing a Knock Predictive Criterion in Spark Ignition Engines Fuelled with Gaseous Fuels

    Institute of Scientific and Technical Information of China (English)

    G.A.Karim

    1993-01-01

    Consideration of the chemical reaction activity of the end gas in a spark ignition and operating conditions are combined to predict the onset of knock and associated performance in an engine fuelled with methane.A two-zone predictive combustion model was developed based on an estimate of the effective duration of the combustion period and the mass burning rate for any set of operating conditions.The unburned end gas preignition chemical reaction activity is described by a detailed chemical reaction kinetic scheme for methane and air,The variation with time of the value of a formulated dimensionless knock parameter(k)is calcuated.It is shown that whenever knocking is encounteren.the value of “k” builds up to a sufficiently high value that exceeds a critical value.Under normal operating conditions,the value of “k” remains throughout the whole combustion period at comparatively very low levels.It is shown that the model and the use of this knock criterion“k” produce results that are in good agreement with experiment.

  6. A NEW METHOD FOR CHARACTERIZING THE KNOCK RESISTANCE OF LNG FUELS USED IN THE TRANSPORTATION MARKET

    NARCIS (Netherlands)

    Levinsky, Howard; Gersen, Sander; van Essen, Martijn; van Dijk, Gerco

    2014-01-01

    To ensure that the engines to be used in LNG-fueled vehicles are matched with the expected variations in fuel composition, the knock resistance of the fuel must be determined unambiguously. Rather than rely on empirical methods using gas mixtures and “standard” engines traditionally employed for

  7. Knock prediction for dual fuel engines by using a simplified combustion model

    Institute of Scientific and Technical Information of China (English)

    费少梅; 刘震涛; 严兆大

    2003-01-01

    The present work used a methane-air mixture chemical kinetics scheme consisting of 119 elementary reaction steps and 41 chemical species to develop a simplified combustion model for prediction of the knock in dual fuel engines. Calculated values by the model for natural gas operation showed good agreement with corresponding experimental values over a broad range of operating conditions.

  8. Maritime Evaluation of Aerosol Fire Knock Down Tools. Part 2: Toxicity and Corrosion Potential

    Science.gov (United States)

    2014-02-01

    i 2014 Fire Research Group Department of Mechanical and Mechatronics Engineering University of Waterloo Waterloo ON Canada N2L 3G1 E. Weckman, A...Topic, T. Sheehan and G.Hitchman MARITIME EVALUATION OF AEROSOL FIRE KNOCK DOWN TOOLS PART 2: TOX CITY AND CORROSION POTENTIAL February, 2014 A report...Exposure .............................. 64 Exposure of Wiped and Unwiped Computer Discs ............................................................ 66

  9. Physicochemical effects of varying fuel composition on knock characteristics of natural gas mixtures

    NARCIS (Netherlands)

    Gersen, Sander; van Essen, Martijn; van Dijk, Gerco; Levinsky, Howard

    2014-01-01

    The physicochemical origins of how changes in fuel composition affect autoignition of the end gas, leading to engine knock, are analyzed for a natural gas engine. Experiments in a lean-burn, high-speed medium-BMEP gas engine are performed using a reference natural gas with systematically varied frac

  10. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

    Directory of Open Access Journals (Sweden)

    Yuan Liu

    2015-01-01

    Full Text Available Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200 gene is a fundamental component for precursor message RNA (pre-mRNA splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP. This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  11. Effects of kettlebell training on postural coordination and jump performance

    DEFF Research Database (Denmark)

    Jay, Kenneth; Jakobsen, Markus Due; Sundstrup, Emil

    2013-01-01

    ABSTRACT: The aim of this study was to investigate the effectiveness of a worksite intervention using kettlebell training to improve postural reactions to perturbation and jump performance.This single-blind randomized controlled trial involved 40 adults (n=40) from occupations with a high....... The outcome measures were postural reactions to sudden perturbation and maximal countermovement jump height.Compared to the control group, the training group significant decreased stopping time following perturbation (-109ms, 95% CI [-196:-21]). Jump height increased significantly in the training group (1.5cm......, 95% CI [0.5:2.5]), but this was non-significantly different from control.Kettlebell training improves postural reactions to sudden perturbation. Future studies should investigate whether kettlebell training can reduce the risk of low-back injury in occupations with manual material handling or patient...

  12. Physiological arousal and perception of bodily state during parachute jumping.

    Science.gov (United States)

    Schedlowski, M; Tewes, U

    1992-01-01

    Heart rate and respiration rate were recorded with a portable data recording system before and during a parachute jump in 36 male sport parachutists with differing degrees of experience. The recordings were analyzed at 12 psychologically relevant points in time along with the subjective ratings of physical arousal. Novice parachutists showed a higher degree of self-rated arousal during jumps. However, the two groups displayed nearly parallel curves for heart and respiration rates, differing significantly from each other only in the level of their respective heart rates. Furthermore, experienced jumpers seem to be better informed about their state of physiological arousal during the jump than are novice jumpers. These results do not confirm the proposed anxiety inhibition process, postulated by Epstein (1967).

  13. Condensation and jumping relay of droplets on lotus leaf

    Science.gov (United States)

    Lv, Cunjing; Hao, Pengfei; Yao, Zhaohui; Song, Yu; Zhang, Xiwen; He, Feng

    2013-07-01

    Dynamic behavior of micro water droplet condensed on a lotus leaf with two-tier roughness is studied. Under laboratory environment, the contact angle of the micro droplet on single micro papilla increases smoothly from 80° to 160° during the growth of condensed water. The best-known "self-cleaning" phenomenon will be lost. A striking observation is the out-of-plane jumping relay of condensed droplets triggered by falling droplets, as well as its sustained speed obtained in continuous jumping relays. The underlying mechanism can be used to enhance the automatic removal of dropwise condensation without the help from any external force. The surface tension energy dissipation is the main reason controlling the critical size of jumping droplet and its onset velocity of rebounding.

  14. Dynamical Jumps in a Shape Memory Alloy Oscillator

    Directory of Open Access Journals (Sweden)

    H. S. Oliveira

    2014-01-01

    Full Text Available The dynamical response of systems with shape memory alloy (SMA elements presents a rich behavior due to their intrinsic nonlinear characteristic. SMA’s nonlinear response is associated with both adaptive dissipation related to hysteretic behavior and huge changes in properties caused by phase transformations. These characteristics are attracting much technological interest in several scientific and engineering fields, varying from medical to aerospace applications. An important characteristic associated with dynamical response of SMA system is the jump phenomenon. Dynamical jumps result in abrupt changes in system behavior and its analysis is essential for a proper design of SMA systems. This paper discusses the nonlinear dynamics of a one degree of freedom SMA oscillator presenting pseudoelastic behavior and dynamical jumps. Numerical simulations show different aspects of this kind of behavior, illustrating its importance for a proper understanding of nonlinear dynamics of SMA systems.

  15. Aerodynamic Jump: A Short Range View for Long Rod Projectiles

    Directory of Open Access Journals (Sweden)

    Mark Bundy

    2001-01-01

    Full Text Available It is shown that aerodynamic jump for a nonspinning kinetic energy penetrator is not – as conventional definitions may infer – a discontinuous change in the direction of motion at the origin of free flight, nor is it the converse, a cumulative redirection over a domain of infinite extent. Rather, with the aid of an alternative kinematical definition, it is shown that aerodynamic jump for such a projectile is a localized redirection of the center-of-gravity motion, caused by the force of lift due to yaw over the relatively short region from entry into free flight until the yaw reaches its first maximum. A rigorous proof of this statement is provided, but the primary objective of this paper is to provide answers to the questions: what is aerodynamic jump, what does it mean, and what aspects of the flight trajectory does it refer to, or account for.

  16. Multiple Tune Jumps to Overcome Horizontal Depolarizing Resonances

    Science.gov (United States)

    Huang, H.; Ahrens, L. A.; Bai, M.; Brown, K. A.; Dutheil, Y.; Gardner, C.; Glenn, J. W.; Lin, F.; Mackay, W. W.; Meot, F.; Poblaguev, A.; Ranjbar, V.; Roser, T.; Schoefer, V.; Tepikian, S.; Tsoupas, N.; Yip, K.; Zelenski, A.; Zeno, K.

    2016-02-01

    Imperfection and vertical intrinsic depolarizing resonances have been overcome by the two partial Siberian snakes in the Alternative Gradient Synchrotron(AGS). The relatively weak but numerous horizontal resonances are the main source of polarization loss in the AGS. A pair of horizontal tune jump quads have been used to overcome these weak resonances. The locations of the two quads have to be chosen such that the disturbance to the beam optics is minimum. The emittance growth has to be mitigated for this method to work. In addition, this technique needs very accurate jump timing. Using two partial Siberian snakes, with vertical tune inside the spin tune gap and 80% polarization at AGS injection, polarized proton beam had reached 1.5 × 1011 proton per bunch with 65% polarization. With the tune jump timing optimized and emittance preserved, more than 70% polarization with 2 × 1011 protons per bunch has been achieved.

  17. Condensation and jumping relay of droplets on lotus leaf

    CERN Document Server

    Lv, Cunjing; Yao, Zhaohui; Song, Yu; Zhang, Xiwen; He, Feng

    2013-01-01

    Dynamic behavior of micro water droplet condensed on a lotus leaf with two-tier roughness is studied. Under laboratory environment, the contact angle of the micro droplet on single micro papilla increases smoothly from 80 deg to 160 deg during the growth of condensed water. The best-known "self-clean" phenomenon, will be lost. A striking observation is the out-of-plane jumping relay of condensed droplets triggered by falling droplets, as well as its sustained speed obtained in continuous jumping relays, enhance the automatic removal of dropwise condensation without the help from any external force. The surface tension energy dissipation is the main reason controlling the critical size of jumping droplet and its onset velocity of rebounding.

  18. Vertical Jump Biomechanics Altered With Virtual Overhead Goal.

    Science.gov (United States)

    Ford, Kevin R; Nguyen, Anh-Dung; Hegedus, Eric J; Taylor, Jeffrey B

    2017-04-01

    Virtual environments with real-time feedback can simulate extrinsic goals that mimic real life conditions. The purpose was to compare jump performance and biomechanics with a physical overhead goal (POG) and with a virtual overhead goal (VOG). Fourteen female subjects participated (age: 18.8 ± 1.1 years, height: 163.2 ± 8.1 cm, weight 63.0 ± 7.9 kg). Sagittal plane trunk, hip, and knee biomechanics were calculated during the landing and take-off phases of drop vertical jump with different goal conditions. Repeated-measures ANOVAs determined differences between goal conditions. Vertical jump height displacement was not different during VOG compared with POG. Greater hip extensor moment (P biomechanical testing, screening, and training conditions.

  19. The acute effect of vibration applications on jumping performance

    Directory of Open Access Journals (Sweden)

    Şener Soylu

    2012-12-01

    Full Text Available Recently, vibration has become very popular as a method of exercise and training and drawn attention of researchers. The aim of this study was to analyses the acute affect of vibration applications as a method of exercise and training on jumping performance. In this study experimental group consists of 25 subjects who are studying at Physical Education and Sports Department of Sakarya University (age 22.2±1.7 years, height 179.2±4.8 cm. body weight 71.5±9.0 kg. This study included a vibration at density of 35 Hz (3x30 sec. frequency  that result from  aerobic exercise that has low density and b just  methods of aerobic exercise (without any vibration that has  low density. Subjects have taken the tests of countermovement and squat jumping after 2 minutes of each application. All applications and tests have been done in nonconsecutive days in a random scheme. In statistical analysis Wilcoxon has been applied in nonparametric scheme. For counter movement jumping; height of jumping,  the difference between before and after  the application of vibration related to the point of peak power and average power has been found significiant (respectively, p<0.05; p<0.05; p<0.01. In addition to this, no statistical difference was found for squat vertical jumping before and after the application of vibration related to the point of peak power and average power (respectively, p>0.05; p>0.05; p>0.05. As a result, it is concluded that vibration that is applied at the range of 35 Hz frequency could increase the performance of acute countermovement jumping

  20. Coalescence-induced jumping of droplet: Inertia and viscosity effects

    Science.gov (United States)

    Farokhirad, Samaneh; Morris, Jeffrey F.; Lee, Taehun

    2015-10-01

    The problem of coalescence-induced self-propelled jumping of droplet is studied using three-dimensional numerical simulation. The focus is on the effect of inertia and in particular the effect of air density on the behavior of the merged droplet during jumping. A lattice Boltzmann method is used for two identical, static micro-droplets coalescing on a homogeneous substrate with contact angle ranging from 0∘ to 180∘. The results reveal that the effect of air density is significant on detachment of the merged droplet from the substrate at the later stage of the jumping process; the larger the air density, the larger the jumping height of the droplet. Analysis of streamlines and vorticity contours is performed for density ratios ranging from 60 to 800. These show a generation of vortical structures inside and around the droplet. The intensity of these structures gets weaker after droplet departure as the air inertia is decreased. The results are also presented in terms of phase diagrams of the merged droplet jumping for different Ohnesorge numbers (Oh) and surface wettabilities for both small and large density ratios. The critical value of contact angle where the merged droplet jumps away from the substrate is independent of density ratio and has a value around 150∘. However, the critical value of Oh depends on both density ratio and wettability of the surface for contact angles greater than 150∘. In this range of contact angle, the diagrams show two distinct dynamical regimes for different density ratios, namely, inertial and viscous regimes.

  1. AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions.

    Science.gov (United States)

    Berry, Scott M; Pezzi, Hannah M; LaVanway, Alex J; Guckenberger, David J; Anderson, Meghan A; Beebe, David J

    2016-06-22

    Analyte isolation is an important process that spans a range of biomedical disciplines, including diagnostics, research, and forensics. While downstream analytical techniques have advanced in terms of both capability and throughput, analyte isolation technology has lagged behind, increasingly becoming the bottleneck in these processes. Thus, there exists a need for simple, fast, and easy to integrate analyte separation protocols to alleviate this bottleneck. Recently, a new class of technologies has emerged that leverages the movement of paramagnetic particle (PMP)-bound analytes through phase barriers to achieve a high efficiency separation in a single or a few steps. Specifically, the passage of a PMP/analyte aggregate through a phase interface (aqueous/air in this case) acts to efficiently "exclude" unbound (contaminant) material from PMP-bound analytes with higher efficiency than traditional washing-based solid-phase extraction (SPE) protocols (i.e., bind, wash several times, elute). Here, we describe for the first time a new type of "exclusion-based" sample preparation, which we term "AirJump". Upon realizing that much of the contaminant carryover stems from interactions with the sample vessel surface (e.g., pipetting residue, wetting), we aim to eliminate the influence of that factor. Thus, AirJump isolates PMP-bound analyte by "jumping" analyte directly out of a free liquid/air interface. Through careful characterization, we have demonstrated the validity of AirJump isolation through comparison to traditional washing-based isolations. Additionally, we have confirmed the suitability of AirJump in three important independent biological isolations, including protein immunoprecipitation, viral RNA isolation, and cell culture gene expression analysis. Taken together, these data sets demonstrate that AirJump performs efficiently, with high analyte yield, high purity, no cross contamination, rapid time-to-isolation, and excellent reproducibility.

  2. The kick-in system: a novel rapid knock-in strategy.

    Directory of Open Access Journals (Sweden)

    Yuko Tomonoh

    Full Text Available Knock-in mouse models have contributed tremendously to our understanding of human disorders. However, generation of knock-in animals requires a significant investment of time and effort. We addressed this problem by developing a novel knock-in system that circumvents several traditional challenges by establishing stem cells with acceptor elements enveloping a particular genomic target. Once established, these acceptor embryonic stem (ES cells are efficient at directionally incorporating mutated target DNA using modified Cre/lox technology. This is advantageous, because knock-ins are not restricted to one a priori selected variation. Rather, it is possible to generate several mutant animal lines harboring desired alterations in the targeted area. Acceptor ES cell generation is the rate-limiting step, lasting approximately 2 months. Subsequent manipulations toward animal production require an additional 8 weeks, but this delimits the full period from conception of the genetic alteration to its animal incorporation. We call this system a "kick-in" to emphasize its unique characteristics of speed and convenience. To demonstrate the functionality of the kick-in methodology, we generated two mouse lines with separate mutant versions of the voltage-dependent potassium channel Kv7.2 (Kcnq2: p.Tyr284Cys (Y284C and p.Ala306Thr (A306T; both variations have been associated with benign familial neonatal epilepsy. Adult mice homozygous for Y284C, heretofore unexamined in animals, presented with spontaneous seizures, whereas A306T homozygotes died early. Heterozygous mice of both lines showed increased sensitivity to pentylenetetrazole, possibly due to a reduction in M-current in CA1 hippocampal pyramidal neurons. Our observations for the A306T animals match those obtained with traditional knock-in technology, demonstrating that the kick-in system can readily generate mice bearing various mutations, making it a suitable feeder technology toward streamlined

  3. The kick-in system: a novel rapid knock-in strategy.

    Science.gov (United States)

    Tomonoh, Yuko; Deshimaru, Masanobu; Araki, Kimi; Miyazaki, Yasuhiro; Arasaki, Tomoko; Tanaka, Yasuyoshi; Kitamura, Haruna; Mori, Fumiaki; Wakabayashi, Koichi; Yamashita, Sayaka; Saito, Ryo; Itoh, Masayuki; Uchida, Taku; Yamada, Junko; Migita, Keisuke; Ueno, Shinya; Kitaura, Hiroki; Kakita, Akiyoshi; Lossin, Christoph; Takano, Yukio; Hirose, Shinichi

    2014-01-01

    Knock-in mouse models have contributed tremendously to our understanding of human disorders. However, generation of knock-in animals requires a significant investment of time and effort. We addressed this problem by developing a novel knock-in system that circumvents several traditional challenges by establishing stem cells with acceptor elements enveloping a particular genomic target. Once established, these acceptor embryonic stem (ES) cells are efficient at directionally incorporating mutated target DNA using modified Cre/lox technology. This is advantageous, because knock-ins are not restricted to one a priori selected variation. Rather, it is possible to generate several mutant animal lines harboring desired alterations in the targeted area. Acceptor ES cell generation is the rate-limiting step, lasting approximately 2 months. Subsequent manipulations toward animal production require an additional 8 weeks, but this delimits the full period from conception of the genetic alteration to its animal incorporation. We call this system a "kick-in" to emphasize its unique characteristics of speed and convenience. To demonstrate the functionality of the kick-in methodology, we generated two mouse lines with separate mutant versions of the voltage-dependent potassium channel Kv7.2 (Kcnq2): p.Tyr284Cys (Y284C) and p.Ala306Thr (A306T); both variations have been associated with benign familial neonatal epilepsy. Adult mice homozygous for Y284C, heretofore unexamined in animals, presented with spontaneous seizures, whereas A306T homozygotes died early. Heterozygous mice of both lines showed increased sensitivity to pentylenetetrazole, possibly due to a reduction in M-current in CA1 hippocampal pyramidal neurons. Our observations for the A306T animals match those obtained with traditional knock-in technology, demonstrating that the kick-in system can readily generate mice bearing various mutations, making it a suitable feeder technology toward streamlined phenotyping.

  4. Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice.

    Science.gov (United States)

    Skoubis, P D; Matthes, H W; Walwyn, W M; Kieffer, B L; Maidment, N T

    2001-01-01

    There is growing evidence that tonic activity of the opioid system may be important in the modulation of affective state. Naloxone produces a conditioned place aversion in rodents, an effect that is centrally mediated. Previous pharmacological data using antagonists with preferential actions at mu-, delta-, and kappa-opioid receptors indicate the importance of the mu-opioid receptor in mediating this effect. We sought to test the mu-opioid receptor selectivity of naloxone aversion using mu-opioid receptor knock-out mice. mu-Opioid receptor knock-out and wild-type mice were tested for naloxone (10 mg/kg, s.c.) aversion using a place conditioning paradigm. As a positive control for associative learning, knock-out mice were tested for conditioned place aversion to a kappa agonist, U50,488H (2 mg/kg, s.c.). Naloxone produced a significant place aversion in wild-type mice, but failed to have any effect in mu-opioid receptor knock-out mice. On the other hand, both knock-out and wild-type mice treated with U50,488H spent significantly less time in the drug-paired chamber compared to their respective vehicle controls. We conclude that the mu-opioid receptor is crucial for the acquisition of naloxone-induced conditioned place aversion. Furthermore, in a separate experiment using C57BL/6 mice, the delta-selective antagonist naltrindole (10 or 30 mg/kg, s.c.) failed to produce conditioned place aversion.Taken together, these data further support the notion that naloxone produces aversion by antagonizing tonic opioid activity at the mu-opioid receptor.

  5. Effect of Timing and Location of Hotspot on Super Knock during Pre-ignition

    KAUST Repository

    Jaasim, Mohammed

    2017-03-28

    Pre-ignition in SI engine is a critical issue that needs addressing as it may lead to super knock event. It is widely accepted that pre-ignition event emanates from hot spot(s) that can be anywhere inside the combustion chamber. The location and timing of hotspot is expected to influence the knock intensity from a pre-ignition event. In this study, we study the effect of location and timing of hot spot inside the combustion chamber using numerical simulations. The simulation is performed using a three-dimensional computational fluid dynamics (CFD) code, CONVERGE™. We simulate 3-D engine geometry coupled with chemistry, turbulence and moving structures (valves, piston). G-equation model for flame tracking coupled with multi-zone model is utilized to capture auto-ignition (knock) and solve gas phase kinetics. A parametric study on the effect of hot spot timing and location inside the combustion chamber is performed. The hot spot timing considered are -180 CAD, -90 CAD and -30 CAD and the locations of the hot spots are in the center and two edges of the piston surfaces. Simulation results for normal combustion cycle are validated against the experimental data. The simulation results show great sensitivity to the hot spot timing, and the influence of local temperature gradient is noted to be significant. In case of early hot spot timing of -180 CAD, the pre-ignition event did not lead to super knock. Nevertheless, at late hot spot timing, super knock was realized. On the other hand, the effect of hot spot location on pre-ignition event depends on the geometry of the combustion chamber.

  6. Sponsored parachute jumps--can they cause prolonged pain?

    OpenAIRE

    Straiton, N; Sterland, J

    1986-01-01

    A survey of parachute injuries sustained in 1984 at a local parachute club was made using hospital notes and a questionnaire. The overall injury rate was 0.2%. The injury rate in first time jumpers was 1.1%. The injuries often resulted in a prolonged hospital stay, time off work and residual pain and disability. Injury rates may be reduced by more prolonged and intensive training preceding the first jumps. Those people not interested in parachuting as a regular sport and who jump once only in...

  7. Sponsored parachute jumps--can they cause prolonged pain?

    Science.gov (United States)

    Straiton, N; Sterland, J

    1986-06-01

    A survey of parachute injuries sustained in 1984 at a local parachute club was made using hospital notes and a questionnaire. The overall injury rate was 0.2%. The injury rate in first time jumpers was 1.1%. The injuries often resulted in a prolonged hospital stay, time off work and residual pain and disability. Injury rates may be reduced by more prolonged and intensive training preceding the first jumps. Those people not interested in parachuting as a regular sport and who jump once only in order to raise money for charity are at risk of serious injury and perhaps should consider less dangerous alternatives.

  8. ASCAN Helms simulates parachute jump during VAFB training exercises

    Science.gov (United States)

    1990-01-01

    1990 Group 13 Astronaut Candidate (ASCAN) Susan J. Helms simulates a parachute jump during ground egress and parasail training exercises at Vance Air Force Base (VAFB), Enid, Oklahoma. With her arms folded against her chest, Helms jumps from a brick platform onto the ground. In line behind her are Charles J. Precourt followed by Leroy Chiao. The training is designed to prepare the ASCANs for proper survival measures to take in the event of an emergency aboard the T-38 jet trainer aircraft they will frequently use once they become full-fledged astronauts. ASCANs completed the VAFB training courses from 07-29-90 through 07-31-90.

  9. Hydrodynamics and energetics of jumping copepod nauplii and copepodids

    DEFF Research Database (Denmark)

    Wadhwa, Navish; Andersen, Anders Peter; Kiørboe, Thomas

    2014-01-01

    , we measured the swimming kinematics and fluid flow around jumping Acartia tonsa at different stages of its life cycle, using particle image velocimetry and particle tracking velocimetry. We found that the flow structures around nauplii and copepodids are topologically different, with one and two...... vortex rings, respectively. Our measurements suggest that copepodids cover a larger distance compared to their body size in each jump and are also hydrodynamically quieter, as the flow disturbance they create attenuates faster with distance. Also, copepodids are energetically more efficient than nauplii...

  10. Aerodynamic Jump: A Short Range View for Long Rod Projectiles

    OpenAIRE

    Mark Bundy

    2001-01-01

    It is shown that aerodynamic jump for a nonspinning kinetic energy penetrator is not – as conventional definitions may infer – a discontinuous change in the direction of motion at the origin of free flight, nor is it the converse, a cumulative redirection over a domain of infinite extent. Rather, with the aid of an alternative kinematical definition, it is shown that aerodynamic jump for such a projectile is a localized redirection of the center-of-gravity motion, caused by the force of lift ...

  11. Jumps into democracy: The transition in the Polity Index

    DEFF Research Database (Denmark)

    Paldam, Martin; Gundlach, Erich

    The Democratic Transition is the process of regime change from authoritarian at the traditional level of development to democratic at the modern level. This process is analyzed on 7,565 pairs of income and political regime data. Regimes are normally in local status quo equilibrium, so they have s......-run changes are due to triggering events that cause regime jumps. Triggering events are almost random, while most jumps are in the direction of the tension. This mechanism integrates the short and the long run to give the transition....

  12. Tunneling of the blocked wave in a circular hydraulic jump

    Science.gov (United States)

    Bhattacharjee, Jayanta K.

    2017-02-01

    The formation of a circular hydraulic jump in a thin liquid layer involves the creation of a horizon where the incoming wave (surface ripples) is blocked by the fast flowing fluid. That there is a jump at the horizon is due to the viscosity of the fluid which is not relevant for the horizon formation. By using a tunneling formalism developed for the study of the Hawking radiation from black holes, we explicitly show that there will be an exponentially small tunneling of the blocked wave across the horizons as anticipated in studies of "analog gravity".

  13. Pricing Participating Products under a Generalized Jump-Diffusion Model

    Directory of Open Access Journals (Sweden)

    Tak Kuen Siu

    2008-01-01

    Full Text Available We propose a model for valuing participating life insurance products under a generalized jump-diffusion model with a Markov-switching compensator. It also nests a number of important and popular models in finance, including the classes of jump-diffusion models and Markovian regime-switching models. The Esscher transform is employed to determine an equivalent martingale measure. Simulation experiments are conducted to illustrate the practical implementation of the model and to highlight some features that can be obtained from our model.

  14. Actionable Information, Repeatability, Quantum Jumps, and the Wavepacket Collapse

    CERN Document Server

    Zurek, Wojciech H

    2013-01-01

    Unknown quantum state cannot be discovered as the measured system is re-prepared -- it jumps into an eigenstate of the measured observable. This impossibility to find out a quantum state and other symptoms of the wavepacket collapse follow (as was recently demonstrated for pure states of measured systems) from unitarity (that doesn't, however, allow for a literal collapse) and from the repeatability of measurements. Here we extend this result to mixtures and decohering systems. This accounts for quantum jumps in a macroscopic and open (but ultimately quantum) apparatus.

  15. Does gymnastics practice improve vertical jump reliability from the age of 8 to 10 years?

    Science.gov (United States)

    Marina, Michel; Torrado, Priscila

    2013-01-01

    The objective of this study was to confirm whether gymnastics practice from a young age can induce greater vertical jump reliability. Fifty young female gymnasts (8.84 ± 0.62 years) and 42 females in the control group (8.58 ± 0.92 years) performed the following jump tests on a contact mat: squat jump, countermovement jump, countermovement jump with arm swing and drop jump from heights of 40 and 60 cm. The two testing sessions had three trials each and were separated by one week. A 2 (groups) × 2 (sessions) × 3 (trials) repeated measures analysis of variance (ANOVA) and a test-retest correlation analysis were used to study the reliability. There was no systematic source of error in either group for non-plyometric jumps such as squat jump, countermovement jump, and countermovement jump with arm swing. A significant group per trial interaction revealed a learning effect in gymnasts' drop jumps from 40 cm height. Additionally, the test-retest correlation analysis and the higher minimum detectable error suggest that the quick drop jump technique was not fully consolidated in either group. At an introductory level of gymnastics and between the ages of 8-10 years, the condition of being a gymnast did not lead to conclusively higher reliability, aside from better overall vertical jump performance.

  16. Relationships among jumping performances and sprint parameters during maximum speed phase in sprinters.

    Science.gov (United States)

    Kale, Mehmet; Aşçi, Alper; Bayrak, Coşkun; Açikada, Caner

    2009-11-01

    The purpose of this study was to investigate the relationships among jumping performances and speed parameters during maximum speed phase in sprinters. Twenty-one men sprinters volunteered to participate at the beginning of the preparation training phase. All tests-including 100-m sprint running, squat jump (SJ), countermovement jump (CMJ), drop jump (DJ), 60-second repetitive jump (RJ), standing long jump (SLJ), standing triple jump (STJ), standing quintuple jump (SQJ), and standing 10-stride jump (STENJ)-were done on switching mats. Flight (FT) and contact times (CT) during the vertical jump tests and 10-m split times during 100-m sprint running were measured by a 2-channel precision timing system (PTS) connected to the mats. The trace marking method was used for measuring the stride length (SL) through 60 m in 100-m sprint running. Stride frequency (SF), maximum velocity (Vmax), jump height for all vertical jumps, and lower-body power in DJ and RJ were calculated. Statistical analysis showed that the highest significant correlation was found between Vmax and DJ height (r = 0.69; p sprint running and SJ (r = 0.39; p sprint running than the other vertical and horizontal jump tests at the beginning of the preparation training phase.

  17. Suicides by jumping from a height in Hong Kong: a review of coroner court files.

    Science.gov (United States)

    Wong, Paul W C; Caine, Eric D; Lee, Carmen K M; Beautrais, Annette; Yip, Paul S F

    2014-02-01

    Jumping from a height is the most common method for suicide in Hong Kong and other urban cities, but it remains understudied locally and internationally. We used Coroner records in exploring the ecological factors associated with these deaths and the personal characteristics of persons who jumped to their death (hereafter, "jumping suicides"). We compared suicides by jumping with all other suicides and examined the suicides that occurred at ten different jumping sites. The Coroner's files of all suicides in Hong Kong from 2002 to 2007 included 6,125 documented deaths. 2,964 (48.4%) involved jumping during the study period. Eighty-three percent (83%) of suicide jumps occurred in residential buildings, and of these, 61% occurred from the decedent's own home. Jumping suicides differed from non-jumping suicides in terms of their socio-demographic characteristics (e.g., for male: 60.8 vs. 67.3% of jumping suicide and non-jumping suicides, p suicides, p suicides (p suicide prevention. Installation of physical barriers, one of the mean restriction strategies, at common places for suicide has strong evidence to avert suicides without substitution effects. There seems to be challenges to implement physical barriers to prevent residential jumping suicides. Simply applying physical barriers to preclude jumping in Hong Kong appears to be difficult given its ubiquitous "high-rise" residential dwellings. Hence, we also need to develop alternative strategies aimed at preventing people from becoming suicidal.

  18. Species status assessment report New Mexico meadow jumping mouse (Zapus hudsonius luteus)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The New Mexico meadow jumping mouse (Zapus hudsonius luteus) (jumping mouse) lives in dense riparian herbaceous vegetation along streams from southern Colorado to...

  19. Application of biological feedback for estimation of anaerobic performance in jumping test

    Directory of Open Access Journals (Sweden)

    Kovalenko S.O.

    2014-10-01

    Full Text Available Purpose : - To determine the effect of biofeedback to determine the level of anaerobic performance of healthy young men. Material: The characteristics of physical performance in 60-seconds jumping test without and with visual and audible biofeedback (BFB are determined at 23 healthy young men. Results : Significant individual peculiarities are found in performance features of 60-seconds jumping test both without and with BFB. The groups of performance indexes are maximum jumping height; jumping frequency and achieved performance level; correlation of jumping phases and achieved capacity of a separate jump; jumping dynamics during the test. The positive effect mostly on performance in BFB regime is found in the group of persons with low level of physical performance. Conclusion : The application of BFB in 60-seconds jumping test is proved to increase the objective character of measuring anaerobic performance.

  20. Aerobic Requirements for and Heart Rate Responses to Variations in Rope Jumping Techniques.

    Science.gov (United States)

    Solis, Ken; And Others

    1988-01-01

    Highly skilled ropejumpers can maintain their exercise intensity by varying their jumping technique. Research on heart rate responses and aerobic requirements of different jumping techniques is discussed. Methodology and data are reported. (Author/JL)

  1. The "how" and "why" of the ancient Greek long jump with weights: a five-fold symmetric jump in a row?

    Science.gov (United States)

    Lenoir, Matthieu; De Clercq, Dirk; Laporte, Willy

    2005-10-01

    A plausible explanation for the ancient long jump records from Greek antiquity is sought on the basis of pictorial and written sources, and corroborated with practical tests. Ancient sources report that athletes jumped more than 15 m with weights in their hands, which enabled them to jump further than without these weights. It is proposed that the ancient Greek long jump was a continuous succession of five standing broad jumps, in which the landing phase of one jump was also the countermovement for the next jump. Four trained athletes jumped further with (14.64 +/- 0.76 m, range 13.64-15.63 m) than without weights (13.88 +/- 0.70 m, range 12.60-14.75 m; P = 0.001). These results show that this technique is executable, fits with ancient written and pictorial sources, and allows trained modern athletes to jump distances well over 15 m. The extra distance jumped when using weights may be due to changes in the position of the jumper's centre of mass at take-off and at landing, and an increase in take-off velocity stemming from several biomechanical mechanisms.

  2. Violence and the Daniel tales in a children’s Bible

    Directory of Open Access Journals (Sweden)

    Marius Nel

    2009-09-01

    Full Text Available Children enjoy the tales of Daniel and his three friends, whether told in Sunday school, day school, by parents or grandparents. These tales are cast essentially in violent terms. In this article a specific version of the tales in a children’s Bible is analysed to show in what way violence serves as the thread that holds the tales together and to suggest that this might imply that violence is condoned, be it violence committed by God for the sake of his children or by his children for their own sakes. Through ideology, criticism and deconstruction it is shown how a socially engaged reading of the text necessitates narrators of the Daniel tales to criticise violence embedded within the Biblical text, especially when these tales are narrated to children.

  3. Mechanically induced ankle inversion during human walking and jumping.

    NARCIS (Netherlands)

    Nieuwenhuijzen, P.H.J.A.; Grüneberg, C.; Duysens, J.E.J.

    2002-01-01

    A new method to study sudden ankle inversions during human walking and jumping is presented. Ankle inversions of 25 degrees were elicited using a box containing a trap door. During the gait task, subjects walked at a speed of 4 km/h. At a pre-programmed delay after left heel strike, an electromagnet

  4. Structural estimation of jump-diffusion processes in macroeconomics

    DEFF Research Database (Denmark)

    Posch, Olaf

    2009-01-01

    This paper shows how to solve and estimate a continuous-time dynamic stochastic general equilibrium (DSGE) model with jumps. It also shows that a continuous-time formulation can make it simpler (relative to its discrete-time version) to compute and estimate the deep parameters using the likelihoo...

  5. Jump Conditions for Maxwell Equations and Their Consequences

    Science.gov (United States)

    2013-01-28

    critical issues in computational modeling of electromagnetic systems containing sliding contacts, such as railguns , is the relationship between...an armature is propelled by electromagnetic force. Two stationary conductors (rails) are connected to a capacitor bank. An armature, typically a solid...experimental results. 15. SUBJECT TERMS Maxwell equation, computational electromagnetics , jump condition 16. SECURITY CLASSIFICATION OF: 17

  6. Environmentally transmitted parasites: Host-jumping in a heterogeneous environment.

    Science.gov (United States)

    Caraco, Thomas; Cizauskas, Carrie A; Wang, Ing-Nang

    2016-05-21

    Groups of chronically infected reservoir-hosts contaminate resource patches by shedding a parasite׳s free-living stage. Novel-host groups visit the same patches, where they are exposed to infection. We treat arrival at patches, levels of parasite deposition, and infection of the novel host as stochastic processes, and derive the expected time elapsing until a host-jump (initial infection of a novel host) occurs. At stationarity, mean parasite densities are independent of reservoir-host group size. But within-patch parasite-density variances increase with reservoir group size. The probability of infecting a novel host declines with parasite-density variance; consequently larger reservoir groups extend the mean waiting time for host-jumping. Larger novel-host groups increase the probability of a host-jump during any single patch visit, but also reduce the total number of visits per unit time. Interaction of these effects implies that the waiting time for the first infection increases with the novel-host group size. If the reservoir-host uses resource patches in any non-uniform manner, reduced spatial overlap between host species increases the waiting time for host-jumping.

  7. Delayed Frost Growth on Jumping-Drop Superhydrophobic Surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Boreyko, Jonathan B [ORNL; Collier, Pat [ORNL

    2013-01-01

    Self-propelled jumping drops are continuously removed from a condensing superhydrophobic surface to enable a micrometric steady-state drop size. Here, we report that subcooled condensate on a chilled superhydrophobic surface are able to repeatedly jump off the surface before heterogeneous ice nucleation occurs. Frost still forms on the superhydrophobic surface due to ice nucleation at neighboring edge defects, which eventually spreads over the entire surface via an inter-drop frost wave. The growth of this inter-drop frost front is shown to be up to three times slower on the superhydrophobic surface compared to a control hydrophobic surface, due to the jumping-drop effect dynamically minimizing the average drop size and surface coverage of the condensate. A simple scaling model is developed to relate the success and speed of inter-drop ice bridging to the drop size distribution. While other reports of condensation frosting on superhydrophobic surfaces have focused exclusively on liquid-solid ice nucleation for isolated drops, these findings reveal that the growth of frost is an inter-drop phenomenon that is strongly coupled to the wettability and drop size distribution of the surface. A jumping-drop superhydrophobic condenser was found to be superior to a conventional dropwise condenser in two respects: preventing heterogeneous ice nucleation by continuously removing subcooled condensate, and delaying frost growth by minimizing the success of interdrop ice bridge formation.

  8. Delayed frost growth on jumping-drop superhydrophobic surfaces.

    Science.gov (United States)

    Boreyko, Jonathan B; Collier, C Patrick

    2013-02-26

    Self-propelled jumping drops are continuously removed from a condensing superhydrophobic surface to enable a micrometric steady-state drop size. Here, we report that subcooled condensate on a chilled superhydrophobic surface are able to repeatedly jump off the surface before heterogeneous ice nucleation occurs. Frost still forms on the superhydrophobic surface due to ice nucleation at neighboring edge defects, which eventually spreads over the entire surface via an interdrop frost wave. The growth of this interdrop frost front is shown to be up to 3 times slower on the superhydrophobic surface compared to a control hydrophobic surface, due to the jumping-drop effect dynamically minimizing the average drop size and surface coverage of the condensate. A simple scaling model is developed to relate the success and speed of interdrop ice bridging to the drop size distribution. While other reports of condensation frosting on superhydrophobic surfaces have focused exclusively on liquid-solid ice nucleation for isolated drops, these findings reveal that the growth of frost is an interdrop phenomenon that is strongly coupled to the wettability and drop size distribution of the surface. A jumping-drop superhydrophobic condenser minimized frost formation relative to a conventional dropwise condenser in two respects: preventing heterogeneous ice nucleation by continuously removing subcooled condensate, and delaying frost growth by limiting the success of interdrop ice bridge formation.

  9. Jump Patterns: Percussive Dance and the Path to Math

    Science.gov (United States)

    Rosenfeld, Malke

    2011-01-01

    In this article, the author describes an innovative collaboration with an elementary school math teacher that leads to original student choreography and engaging mathematical thinking. Using a tool the author created called Jump Patterns, students at Fox Hill Elementary School in Indianapolis, Indiana, engage in a robust, creative, choreographic…

  10. A logarithmic interpretation of Edixhoven's jumps for Jacobians

    DEFF Research Database (Denmark)

    Eriksson, Dennis; Halle, Lars Halvard; Nicaise, Johannes

    2015-01-01

    Let A be an abelian variety over a discretely valued field. Edixhoven has defined a filtration on the special fiber of the N\\'eron model of A that measures the behaviour of the N\\'eron model under tame base change. We interpret the jumps in this filtration in terms of lattices of logarithmic...

  11. The Hydraulic Jump: Finding Complexity in Turbulent Water

    Science.gov (United States)

    Vondracek, Mark

    2013-01-01

    Students who do not progress to more advanced science disciplines in college generally do not realize that seemingly simple physical systems are--when studied in detail--more complex than one might imagine. This article presents one such phenomenon--the hydraulic jump--as a way to help students see the complexity behind the seemingly simple, and…

  12. Anticipating the Species Jump: Surveillance for Emerging Viral Threats

    Science.gov (United States)

    2010-12-01

    broken skin or injection). Tropism is the affinity that a given virus has for particular host cell receptors, cells or tissues. Fusion/Entry...be a descendant of a cat virus ( feline panleukopenia virus, FPV) that jumped from cats to dogs within five years prior to its emergence. Since that

  13. The Viability Property of Controlled Jump Diffusion Processes

    Institute of Scientific and Technical Information of China (English)

    Shi Ge PENG; Xue Hong ZHU

    2008-01-01

    In this paper,we first give a comparison theorem of viscosity solution to some nonlinear second order integrodifferential equation.And then using the comparison theorem,we obtain a necessary and sufficient condition for the viability property of some controlled jump diffusion processes which can keep the solution within a constraint K.

  14. Jumping across the gap - a series of atrial extrastimuli.

    Science.gov (United States)

    Swamy, Mahadeva; Katyal, Deepak; Raja J, Kaushal

    2015-01-01

    The "gap phenomenon" is an interesting phenomenon in electrophysiology arising from the differences in refractory periods at two or more levels of the atrioventricular (AV) conduction system. We present a patient with dual AV nodal physiology in whom the AH jump mediates the gap phenomenon. We also briefly discuss the other mechanisms of gap phenomenon that have been described in this setting.

  15. Hydraulic Jump and Energy Dissipation with Sluice Gate

    Directory of Open Access Journals (Sweden)

    Youngkyu Kim

    2015-09-01

    Full Text Available Movable weirs have been developed to address the weaknesses of conventional fixed weirs. However, the structures for riverbed protection downstream of movable weirs are designed using the criteria of fixed weirs in most cases, and these applications cause problems, such as scour and deformation of structures, due to misunderstanding the difference between different types of structures. In this study, a hydraulic experiment was conducted to examine weir type-specific hydraulic phenomena, compare hydraulic jumps and downstream flow characteristics according to different weir types, and analyze hydraulic characteristics, such as changes in water levels, velocities and energy. Additionally, to control the flow generated by a sluice gate, energy dissipators were examined herein for their effectiveness in relation to different installation locations and heights. As a result, it was found that although sluice gates generated hydraulic jumps similar to those of fixed weirs, their downstream supercritical flow increased to eventually elongate the overall hydraulic jumps. In energy dissipator installation, installation heights were found to be sensitive to energy dissipation. The most effective energy dissipator height was 10% of the downstream free surface water depth in this experiment. Based on these findings, it seems desirable to use energy dissipators to reduce energy, as such dissipators were found to be effective in reducing hydraulic jumps and protecting the riverbed under sluice gates.

  16. Mechanically induced ankle inversion during human walking and jumping.

    NARCIS (Netherlands)

    Nieuwenhuijzen, P.H.J.A.; Grüneberg, C.; Duysens, J.E.J.

    2002-01-01

    A new method to study sudden ankle inversions during human walking and jumping is presented. Ankle inversions of 25 degrees were elicited using a box containing a trap door. During the gait task, subjects walked at a speed of 4 km/h. At a pre-programmed delay after left heel strike, an electromagnet

  17. Fact or friction: jumps at ultra high frequency

    NARCIS (Netherlands)

    K. Christensen; R. Oomen; M. Podolskij

    2011-01-01

    In this paper, we demonstrate that jumps in financial asset prices are not nearly as common as generally thought, and that they account for only a very small proportion of total return variation. We base our investigation on an extensive set of ultra high-frequency equity and foreign exchange rate d

  18. Mechanical output in jumps of marmosets (Callithrix jacchus).

    Science.gov (United States)

    Bobbert, Maarten F; Plas, Rogier L C; Weide, Guido; Clairbois, H E Bert; Hofman, Sam O; Jaspers, Richard T; Philippens, Ingrid H C H M

    2014-02-15

    In this study we determined the mechanical output of common marmosets (Callithrix jacchus) during jumping. Vertical ground reaction forces were measured in 18 animals while they jumped from an instrumented crossbar to a crossbar located 70 cm higher. From the vertical force time histories, we calculated the rate of change of mechanical energy of the centre of mass (dE/dt). The mean value of dE/dt during the push-off amounted to 51.8±6.2 W kg(-1) body mass, and the peak value to 116.4±17.6 W kg(-1) body mass. We used these values in combination with masses of leg muscles, determined in two specimens, to estimate mean and peak values of dE/dt of 430 and 970 W kg(-1) muscle, respectively. These values are higher than values reported in the literature for jumps of humans and bonobos, but smaller than those of jumps of bushbabies. Surprisingly, the mean value of dE/dt of 430 W kg(-1) muscle was close to the maximal power output of 516 W kg(-1) muscle reported in the literature for isokinetic contractions of rat medial gastrocnemius, one of the fastest mammalian muscles. Further study of the force-velocity relationship of muscle tissue of small primates is indicated.

  19. Propulsion efficiency and imposed flow fields of a copepod jump

    DEFF Research Database (Denmark)

    Jiang, H.; Kiørboe, Thomas

    2011-01-01

    velocity vectors pointing towards the copepod; such a flow field may inform the predator of the whereabouts of the escaping copepod prey. High Froude propulsion efficiency (0.94–0.98) was obtained for individual power stroke durations of all simulated jumps. This is unusual for small aquatic organisms...

  20. Firms' Overseas Investment Jumps to US$6.9 Billion

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Foreign investment by domestic firms, excluding banks,jumped 26% last year to US$6.9 billion, the Ministry of Commerce said on February 10. The government has been encouraging domestic companies to head overseas to secure resources, build brands and win market share, and it also welcomes the effect an outflow of investment has on the yuan.

  1. The Missing Luminous Blue Variables and the Bistability Jump

    NARCIS (Netherlands)

    N. Smith; J.S. Vink; A. de Koter

    2004-01-01

    We discuss an interesting feature of the distribution of luminous blue variables (LBVs) on the H-R diagram, and we propose a connection with the bistability jump seen in the winds of early-type supergiants. There appears to be a deficiency of quiescent LBVs on the S Doradus instability strip at lumi

  2. Asymptotic Behaviour and Extinction of Delay Lotka-Volterra Model with Jump-Diffusion

    OpenAIRE

    Dan Li,; Jing’an Cui; Guohua Song

    2014-01-01

    This paper studies the effect of jump-diffusion random environmental perturbations on the asymptotic behaviour and extinction of Lotka-Volterra population dynamics with delays. The contributions of this paper lie in the following: (a) to consider delay stochastic differential equation with jumps, we introduce a proper initial data space, in which the initial data may be discontinuous function with downward jumps; (b) we show that the delay stochastic differential equation with jumps associate...

  3. Jumping for recognition: Women's ski jumping viewed as a struggle for rights.

    Science.gov (United States)

    Andersen, W; Loland, S

    2017-03-01

    With the campaign for women's participation in international and Olympic ski jumping as a practical case, sport's potential for recognition of individual rights is explored. In line with Honneth's influential ethical theory, recognition of rights refers to a mutual recognition between persons of each other as rational and responsible agents with an equal right to take part in the public formation and development of their community or practice. The argument is that women ski jumpers were entitled to compete as they had actual and/or potential capabilities and skills to contribute in the public formation and development of their sport. Their exclusion was a violation of individual rights. At a more general level, sport is discussed as a sphere for recognition of rights. It is argued that the basic principles of equal opportunity to take part and to perform make sport a particularly clear and potent sphere for such recognition, and also for the identification of rights violations. In sport, rights, or the violation of rights, are demonstrated in concrete and embodied ways. It is concluded that struggles for recognition and individual rights are a continuous process in sport as in most other human institutions and practices.

  4. P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments

    DEFF Research Database (Denmark)

    Ejsing, Thomas B.; Pedersen, Anne D.; Linnet, Kristian

    2005-01-01

    P-glycoprotein, risperidone, nortriptyline, cyclosporine A, drug-drug interaction, blood-brain barrier, knock-out mice......P-glycoprotein, risperidone, nortriptyline, cyclosporine A, drug-drug interaction, blood-brain barrier, knock-out mice...

  5. Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification

    KAUST Repository

    Li, Lixin

    2012-01-22

    Transcription activator-like effectors (TALEs) can be used as DNA-targeting modules by engineering their repeat domains to dictate user-selected sequence specificity. TALEs have been shown to function as site-specific transcriptional activators in a variety of cell types and organisms. TALE nucleases (TALENs), generated by fusing the FokI cleavage domain to TALE, have been used to create genomic double-strand breaks. The identity of the TALE repeat variable di-residues, their number, and their order dictate the DNA sequence specificity. Because TALE repeats are nearly identical, their assembly by cloning or even by synthesis is challenging and time consuming. Here, we report the development and use of a rapid and straightforward approach for the construction of designer TALE (dTALE) activators and nucleases with user-selected DNA target specificity. Using our plasmid set of 100 repeat modules, researchers can assemble repeat domains for any 14-nucleotide target sequence in one sequential restriction-ligation cloning step and in only 24 h. We generated several custom dTALEs and dTALENs with new target sequence specificities and validated their function by transient expression in tobacco leaves and in vitro DNA cleavage assays, respectively. Moreover, we developed a web tool, called idTALE, to facilitate the design of dTALENs and the identification of their genomic targets and potential off-targets in the genomes of several model species. Our dTALE repeat assembly approach along with the web tool idTALE will expedite genome-engineering applications in a variety of cell types and organisms including plants. © 2012 Springer Science+Business Media B.V.

  6. Face value in A Tale of Two Cities

    OpenAIRE

    Elliott, Kamilla

    2009-01-01

    This essay considers how proper names and faces construct, destruct, and reconstruct social identity in A tale of two cities. Manette’s identification at the start of the novel, for example, occurs chiefly through a recalled proper name and face. As the French Revolution worked to destroy privileged, individuated identities, so too have contemporary theories of identity, which dismiss individual identity and remain preoccupied with identity at the level of common nouns and generic bodies. How...

  7. Time-resolved methods in biophysics. 9. Laser temperature-jump methods for investigating biomolecular dynamics.

    Science.gov (United States)

    Kubelka, Jan

    2009-04-01

    Many important biochemical processes occur on the time-scales of nanoseconds and microseconds. The introduction of the laser temperature-jump (T-jump) to biophysics more than a decade ago opened these previously inaccessible time regimes up to direct experimental observation. Since then, laser T-jump methodology has evolved into one of the most versatile and generally applicable methods for studying fast biomolecular kinetics. This perspective is a review of the principles and applications of the laser T-jump technique in biophysics. A brief overview of the T-jump relaxation kinetics and the historical development of laser T-jump methodology is presented. The physical principles and practical experimental considerations that are important for the design of the laser T-jump experiments are summarized. These include the Raman conversion for generating heating pulses, considerations of size, duration and uniformity of the temperature jump, as well as potential adverse effects due to photo-acoustic waves, cavitation and thermal lensing, and their elimination. The laser T-jump apparatus developed at the NIH Laboratory of Chemical Physics is described in detail along with a brief survey of other laser T-jump designs in use today. Finally, applications of the laser T-jump in biophysics are reviewed, with an emphasis on the broad range of problems where the laser T-jump methodology has provided important new results and insights into the dynamics of the biomolecular processes.

  8. Neuromuscular adaptations to 4 weeks of intensive drop jump training in well-trained athletes

    DEFF Research Database (Denmark)

    Alkjær, Tine; Meyland, Jacob; Raffalt, Peter C

    2013-01-01

    This study examined the effects of 4 weeks of intensive drop jump training in well-trained athletes on jumping performance and underlying changes in biomechanics and neuromuscular adaptations. Nine well-trained athletes at high national competition level within sprinting and jumping disciplines...

  9. Muscle activation history at different vertical jumps and its influence on vertical velocity

    NARCIS (Netherlands)

    Kopper, Bence; Csende, Zsolt; Safar, Sandor; Hortobagyi, Tibor; Tihanyi, Jozsef

    In the present study we investigated displacement, time, velocity and acceleration history of center of mass (COM) and electrical activity of knee extensors to estimate the dominance of the factors influencing the vertical velocity in squat jumps (SJs), countermovement jumps (CMJs) and drop jumps

  10. Muscle activation history at different vertical jumps and its influence on vertical velocity

    NARCIS (Netherlands)

    Kopper, Bence; Csende, Zsolt; Safar, Sandor; Hortobagyi, Tibor; Tihanyi, Jozsef

    2013-01-01

    In the present study we investigated displacement, time, velocity and acceleration history of center of mass (COM) and electrical activity of knee extensors to estimate the dominance of the factors influencing the vertical velocity in squat jumps (SJs), countermovement jumps (CMJs) and drop jumps (D

  11. Psycho-physiological response in an automatic parachute jump.

    Science.gov (United States)

    Clemente-Suárez, Vicente Javier; Robles-Pérez, José Juan; Fernández-Lucas, Jesús

    2016-10-11

    Parachute jump is an extreme activity that elicits an intense stress response that affects jumpers' body systems being able to put them at risk. The present research analysed modifications in blood oxygen saturation (BOS), heart rate (HR), cortisol, glucose, lactate, creatine kinase (CK), muscles strength, cortical arousal, autonomic modulation, pistol magazine reload time (PMRT) and state anxiety before and after an automatic open parachute jump in 38 male Spanish soldiers (25.6 ± 5.9 years). A MANOVA with samples as a fixed factor and Effect Size (ES) were conducted. MANOVA showed (Wilks lambda = .225; F = 5.980; P = .000) a significantly increase in cortisol (6.2 ± 3.2 vs. 8.2 ± 4.3 nmol/l; P = .025; ES = .47), HR (75.0 ± 14.6 vs. 87.4 ± 17.3 bpm; P = .004; ES = .72), lactate (1.8 ± 1.2 vs. 4.4 ± 2.2 mmol · l(-1); P = .002; ES = 1.18), sympathetic nervous system and leg strength manifestation after the parachute jump. By contrary BOS, PMRT (55.6 ± 27.6 vs. 48.0 ± 16.7 s; P = .021; ES = .46) and somatic anxiety (SA), evaluated by CSAI2R questionnaire, decreased. An automatic parachute jump increased physiological and cortical response and decreased SA of participants. This stress response can affect the jumpers' abilities and allow us to have a better understanding of the organism stress response and to improve training for both military and sport parachute jumps.

  12. Lack of association between postactivation potentiation and subsequent jump performance.

    Science.gov (United States)

    Pearson, Stephen John; Hussain, Syed Robiul

    2014-01-01

    Postactivation potentiation (PAP) is a strategy that has been used to acutely enhance the performance of explosive activities. Although, isometric maximal voluntary contractions (MVCs) have previously been shown to enhance subsequent explosive performance, no information currently exists regarding (1) the optimal variables (intensity/volume) of a MVC that best elicits a PAP response, and (2) the utilisation of evoked isometric twitch contractions in combination with performance measures to directly ascertain the presence of PAP following a MVC, and its relationship to performance. Thus, the purpose of this study was to (1) investigate the influence of isometric contraction duration on the PAP response, and (2) to determine the relationship between PAP, indicated as potentiation of muscle twitch force and subsequent jump performance following different-duration MVCs. Eight males (age: 21 ± 0.99) were assessed using performance measures [countermovement jumps] and evoked twitch contractions, before and 4 minutes after three different conditioning contractions (CCs), (1) a 3-second MVC (MVC3), (2) a 5-second MVC (MVC5) and (3) a 7-second MVC (MVC7). Following all CCs, peak twitch torque of the knee extensor muscles was found to increase (MVC3, + 3.9%; MVC5, + 9.6%; MVC7, + 5.2%), although not significantly (P > 0.05). No significant increases in jump height, jump power, rate of force development or takeoff velocity were observed following any of the CCs (P > 0.05). There was also a lack of association between the changes in PAP (twitch torque) and jump height following all CCs (MVC3, r = 0.25; MVC5, r = 0.28; MVC7, r = -0.47). These data indicate that PAP as assessed via twitch contractions is not associated with performance measures subsequent to single-set isometric CCs of varying durations.

  13. The kinematics of swimming and relocation jumps in copepod nauplii.

    Directory of Open Access Journals (Sweden)

    Christian Marc Andersen Borg

    Full Text Available Copepod nauplii move in a world dominated by viscosity. Their swimming-by-jumping propulsion mode, with alternating power and recovery strokes of three pairs of cephalic appendages, is fundamentally different from the way other microplankters move. Protozoans move using cilia or flagella, and copepodites are equipped with highly specialized swimming legs. In some species the nauplius may also propel itself more slowly through the water by beating and rotating the appendages in a different, more complex pattern. We use high-speed video to describe jumping and swimming in nauplii of three species of pelagic copepods: Temora longicornis, Oithona davisae and Acartia tonsa. The kinematics of jumping is similar between the three species. Jumps result in a very erratic translation with no phase of passive coasting and the nauplii move backwards during recovery strokes. This is due to poorly synchronized recovery strokes and a low beat frequency relative to the coasting time scale. For the same reason, the propulsion efficiency of the nauplii is low. Given the universality of the nauplius body plan, it is surprising that they seem to be inefficient when jumping, which is different from the very efficient larger copepodites. A slow-swimming mode is only displayed by T. longicornis. In this mode, beating of the appendages results in the creation of a strong feeding current that is about 10 times faster than the average translation speed of the nauplius. The nauplius is thus essentially hovering when feeding, which results in a higher feeding efficiency than that of a nauplius cruising through the water.

  14. Changes in biomechanical properties during drop jumps of incremental height.

    Science.gov (United States)

    Peng, Hsien-Te

    2011-09-01

    The purpose of this study was to investigate changing biomechanical properties with increasing drop jump height. Sixteen physically active college students participated in this study and performed drop jumps from heights of 20, 30, 40, 50, and 60 cm (DJ20-DJ60). Kinematic and kinetic data were collected using 11 Eagle cameras and 2 force platforms. Data pertaining to the dominant leg for each of 3 trials for each drop height were recorded and analyzed. Statistical comparisons of vertical ground reaction force (vGRF), impulse, moment, power, work, and stiffness were made between different drop jump heights. The peak vGRF of the dominant leg exceeded 3 times the body weight during DJ50 and DJ60; these values were significantly greater than those for DJ20, DJ30, and DJ40 (all p height jumped during DJ60 was significantly less than that during DJ20 and DJ30 (both p = 0.010). Both the landing impulse and total impulse during the contact phase were significantly different between each drop height (all p height. There were no significant differences in the takeoff impulse. Peak and mean power absorption and negative work at the knee and ankle joints during DJ40, DJ50, and DJ60 were significantly greater than those during DJ20 and DJ30 (all p heights >40 cm offered no advantages in terms of mechanical efficiency (SSC power output) and stiffness. Drop jumps from heights in excess of 60 cm are not recommended because of the lack of biomechanical efficiency and the potentially increased risk of injury.

  15. A Study of Chinese Translations and Interpretations of H.C. Andersen's Tales

    DEFF Research Database (Denmark)

    Li, Wenjie

    H. C. Andersen’s tales are considered as classical fairy tales in China. How they have achieved this canonical status is one of the concerns of this study. Taking a historical point of view, this thesis intends to examine how the Chinese translations and interpretations of his tales, since......-political factors like economics and ideology, as well as human factors such as patrons, translators, and readers, have influenced the Chinese translations and interpretations of Andersen’s tales. However, this thesis is not merely a history about facts like names and dates. It also involves observations...

  16. Modern Monetary Policy and Central Bank Governance: A Story of Two Tales

    OpenAIRE

    Eijffinger, S.C.W.; Masciandaro, D.

    2014-01-01

    The objective of this note is to present the evolution of both the economics and the political economy of monetary policy in the last three decades – first the Great Moderation and then the Financial Crisis – as a story of two intertwined tales: on the one side the tale of how to govern money and interest rates in the short run; on the other side the tale of how to design in a longer horizon the monetary architectures. In the tradition the two tales are told separately, where the academic sch...

  17. TALE activators regulate gene expression in a position- and strand-dependent manner in mammalian cells.

    Science.gov (United States)

    Uhde-Stone, Claudia; Cheung, Edna; Lu, Biao

    2014-01-24

    Transcription activator-like effectors (TALEs) are a class of transcription factors that are readily programmable to regulate gene expression. Despite their growing popularity, little is known about binding site parameters that influence TALE-mediated gene activation in mammalian cells. We demonstrate that TALE activators modulate gene expression in mammalian cells in a position- and strand-dependent manner. To study the effects of binding site location, we engineered TALEs customized to recognize specific DNA sequences located in either the promoter or the transcribed region of reporter genes. We found that TALE activators robustly activated reporter genes when their binding sites were located within the promoter region. In contrast, TALE activators inhibited the expression of reporter genes when their binding sites were located on the sense strand of the transcribed region. Notably, this repression was independent of the effector domain utilized, suggesting a simple blockage mechanism. We conclude that TALE activators in mammalian cells regulate genes in a position- and strand-dependent manner that is substantially different from gene activation by native TALEs in plants. These findings have implications for optimizing the design of custom TALEs for genetic manipulation in mammalian cells.

  18. Assembly of custom TALE-type DNA binding domains by modular cloning.

    Science.gov (United States)

    Morbitzer, Robert; Elsaesser, Janett; Hausner, Jens; Lahaye, Thomas

    2011-07-01

    Transcription activator-like effector (TALE) DNA binding proteins show tremendous potential as molecular tools for targeted binding to any desired DNA sequence. Their DNA binding domain consists of tandem arranged repeats, and due to this repetitive structure it is challenging to generate designer TALEs (dTALEs) with user-defined specificity. We present a cloning approach that facilitates the assembly of multiple repeat-encoding DNA fragments that translate into dTALEs with pre-defined DNA binding specificity. This method makes use of type IIS restriction enzymes in two sequential cut-ligase reactions to build dTALE repeat arrays. We employed this modular approach for generation of a dTALE that differentiates between two highly similar DNA sequences that are both targeted by the Xanthomonas TALE, AvrBs3. These data show that this modular assembly system allows rapid generation of highly specific TALE-type DNA binding domains that target binding sites of predefined length and sequence. This approach enables the rapid and flexible production of dTALEs for gene regulation and genome editing in routine and high-throughput applications.

  19. Tales of the quantum understanding physics' most fundamental theory

    CERN Document Server

    Hobson, Art

    2016-01-01

    This is a book about the quanta that make up our universe--the highly unified bundles of energy of which everything is made. It explains wave-particle duality, randomness, quantum states, non-locality, Schrodinger's cat, quantum jumps, and more, in everyday language for non-scientists and scientists who wish to fathom science's most fundamental theory.

  20. A Knock-in Reporter for a Novel AR-Targeted Therapy

    Science.gov (United States)

    2016-05-01

    MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of...carrying FLuc in the AR gene locus and thereby bicistronically co-expressing the reporter gene with AR under the control of the endogenous AR promoter and...AR gene under the control of the endogenous AR promoter and enhancer. Such a knock-in reporter can faithfully reproduce chemical responses of the

  1. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction

    OpenAIRE

    Gourley, Shannon L.; Howell, Jessica L.; Rios, Maribel; DiLeone, Ralph J.; Taylor, Jane R

    2009-01-01

    Anatomically selective medial prefrontal cortical projections regulate the extinction of stimulus–reinforcement associations, but the mechanisms underlying extinction of an instrumental response for reward are less well-defined and may involve structures that regulate goal-directed action. We show brain-derived neurotrophic factor (bdnf) knock-down in the prelimbic, but not orbitofrontal, cortex accelerates the initial extinction of instrumental responding for food and reduces striatal BDNF p...

  2. Combustion Analysis and Knock Detection in Single Cylinder DI-Diesel Engine Using Vibration Signature Analysis

    OpenAIRE

    Y.V.V.SatyanarayanaMurthy

    2011-01-01

    The purpose of this paper is to detect the “knock” in Diesel engines which deteriorate the engine performance adversely. The methodology introduced in the present work suggests a newly developed approach towards analyzing the vibration analysis of diesel engines. The method is based on fundamental relationship between the engine vibration pattern and the relative characteristics of the combustion process in each or different cylinders. Knock in diesel engine is detected by measuring the vibra...

  3. Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current

    OpenAIRE

    Schutte, Ryan J.; Schutte, Soleil S.; Algara, Jacqueline; Barragan, Eden V.; Gilligan, Jeff; Staber, Cynthia; Savva, Yiannis A.; Smith, Martin A.; Reenan, Robert; O'Dowd, Diane K.

    2014-01-01

    Hundreds of mutations in the SCN1A sodium channel gene confer a wide spectrum of epileptic disorders, requiring efficient model systems to study cellular mechanisms and identify potential therapeutic targets. We recently demonstrated that Drosophila knock-in flies carrying the K1270T SCN1A mutation known to cause a form of genetic epilepsy with febrile seizures plus (GEFS+) exhibit a heat-induced increase in sodium current activity and seizure phenotype. To determine whether different SCN1A m...

  4. Keeping your eye on the rail: gaze behaviour of horse riders approaching a jump.

    Directory of Open Access Journals (Sweden)

    Carol Hall

    Full Text Available The gaze behaviour of riders during their approach to a jump was investigated using a mobile eye tracking device (ASL Mobile Eye. The timing, frequency and duration of fixations on the jump and the percentage of time when their point of gaze (POG was located elsewhere were assessed. Fixations were identified when the POG remained on the jump for 100 ms or longer. The jumping skill of experienced but non-elite riders (n = 10 was assessed by means of a questionnaire. Their gaze behaviour was recorded as they completed a course of three identical jumps five times. The speed and timing of the approach was calculated. Gaze behaviour throughout the overall approach and during the last five strides before take-off was assessed following frame-by-frame analyses. Differences in relation to both round and jump number were found. Significantly longer was spent fixated on the jump during round 2, both during the overall approach and during the last five strides (p<0.05. Jump 1 was fixated on significantly earlier and more frequently than jump 2 or 3 (p<0.05. Significantly more errors were made with jump 3 than with jump 1 (p = 0.01 but there was no difference in errors made between rounds. Although no significant correlations between gaze behaviour and skill scores were found, the riders who scored higher for jumping skill tended to fixate on the jump earlier (p = 0.07, when the horse was further from the jump (p = 0.09 and their first fixation on the jump was of a longer duration (p = 0.06. Trials with elite riders are now needed to further identify sport-specific visual skills and their relationship with performance. Visual training should be included in preparation for equestrian sports participation, the positive impact of which has been clearly demonstrated in other sports.

  5. Possibility of stretch-shortening cycle movement training using a jump rope.

    Science.gov (United States)

    Miyaguchi, Kazuyoshi; Sugiura, Hiroki; Demura, Shinichi

    2014-03-01

    Although jumping rope has been said to be a typical stretch-shortening cycle movement (SSC) from the dynamic analysis of muscle contraction, there are few research reports that focus on this point. Recently, the function of SSC of the legs with respect to the jumping movement has been evaluated using the rebound jump index (RJ-index). This study aimed to examine the possibility of using rope jumping in SSC training by comparing the RJ-index of the rebound jump (standard value) and the 2 different methods of rope jumping. The subjects included 76 healthy young men. Most subjects were involved in routine sports training 2-3 times per week. They performed the rebound jump (5 consecutive vertical jumps) and both a basic and a double-under jump with the jump rope, according to each participant's individual style (rhythm or timing). The RJ-index was calculated using the ground contact time and the jump height. The reliabilities of the RJ-index in the basic (intraclass correlation coefficient: 0.85) and double-under jump (0.92) were high, and the RJ-index of the latter (1.34 ± 0.24) was significantly higher than that of the former (0.60 ± 0.21). In the case of a group with inferior SSC ability, the RJ-index of the rebound jump only showed a significant correlation with the double-under but not with the basic jump. When using the RJ-index (1.97 ± 0.38) of the rebound jump as a criterion, the double-under-using about 70% of the SSC ability-may be effective for reinforcement of SSC ability.

  6. Comparison of spectral analysis of vibration using commercial knock sensor and 3-axis acceleration sensor

    Science.gov (United States)

    Zieliński, Ł.; Walczak, D.; Szczurowski, K.; Radkowski, S.

    2016-09-01

    With the development of internal combustion engines, engineers attempt to reduce the noise and vibration generated. Due to the high cost of fuel, are increasingly looking for new sources of power in order to reduce costs. In diesel engines, an increasingly popular method is the admixture of propane-butane. This follows because of the price of the fuel as well as to improve the efficiency of combustion. With the development of this type of dual fuel power seems to be a reasonable study of the effects of LPG to generate noise and vibration, as well as an attempt to evaluate the combustion process. Unfortunately, too much addition of LPG causes a phenomenon called knock consisting in abnormal, uneven, explosive combustion of fuels in reciprocating engines. This phenomenon may lead to a reduction in engine performance and permanent damage. Control of the knock detection uses vibration acceleration sensors recording the high frequency ranges. Within the framework of the research conducted by the team of authors, an attempt was made to compare the vibroacoustic signals originating from the commercial knocking sensor with a three-axis acceleration sensor. These signals were subject to a quick Fourier transform in the purpose of analysing the amplitude spectra.

  7. Evaluation of Anti-Knock Quality of Dicyclopentadiene-Gasoline Blends

    KAUST Repository

    Al-Khodaier, Mohannad

    2017-03-28

    Increasing the anti-knock quality of gasoline fuels can enable higher efficiency in spark ignition engines. In this study, the blending anti-knock quality of dicyclopentadiene (DCPD), a by-product of ethylene production from naphtha cracking, with various gasoline fuels is explored. The blends were tested in an ignition quality tester (IQT) and a modified cooperative fuel research (CFR) engine operating under homogenous charge compression ignition (HCCI) and knock limited spark advance (KLSA) conditions. Due to current fuel regulations, ethanol is widely used as a gasoline blending component in many markets. In addition, ethanol is widely used as a fuel and literature verifying its performance. Moreover, because ethanol exhibits synergistic effects, the test results of DCPD-gasoline blends were compared to those of ethanol-gasoline blends. The experiments conducted in this work enabled the screening of DCPD auto-ignition characteristics across a range of combustion modes. The synergistic blending nature of DCPD was apparent and appeared to be greater than that of ethanol. The data presented suggests that DCPD has the potential to be a high octane blending component in gasoline; one which can substitute alkylates, isomerates, reformates, and oxygenates.

  8. Bounce-averaged Fokker-Planck Simulation of Runaway Avalanche from Secondary Knock-on Production

    Science.gov (United States)

    Chiu, S. C.; Chan, V. S.; Harvey, R. W.; Rosenbluth, M. N.

    1996-11-01

    It has been pointed out that secondary production of runaway electrons by knock-on collisions with very energetic confined electrons can significantly change the runaway rate,(M.N. Rosenbluth, Bull. Amer. Phys. Soc. 40), 1804 (1995).^,(N.T. Besedin, I.M. Pankratov, Nucl. Fusion 26), 807 (1986).^,(R. Jaspers, K.H. Finden, G. Mank et al.), Nucl. Fusion 33, 1775 (1993). and is potentially a serious problem in reactors. Previous calculations of the effect have only partially included important effects such as toroidal trapping, synchrotron radiation, and bremsstrahlung. Furthermore, in a normal constant current operation, the increase of the density of runaway electrons causes a decrease of the ohmic field and all these effects can balance to a steady-state. The purpose of the present paper is to present results on bounce-averaged Fokker-Planck simulations of knock-on avalanching runaways including these effects. Initially, an energetic seed component is inserted to initiate knock-on avalanching. Results on the dependence of the steady-state runaway current on Z_eff, density, and radial location will be presented.

  9. Effect of Tbxl knock-down on cardiac performance in zebrafish

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-feng; GUI Yong-hao; WANG Yue-xiang; JIANG Qiu; SONG Hou-yan

    2010-01-01

    Background Tbxl is the major candidate gene for DiGeorge syndrome (DGS). Similar to defects observed in DGS patients, the structures disrupted in Tbxl-/- animal models are derived from the neural crest cells during development. Although the morphological phenotypes of some Tbxl knock-down animal models have been well described, analysis of the cardiac performance is limited. Therefore, myocardial performance was explored in Tbxl morpholino injected zebrafish embryos. Methods To elucidate these issues, Tbxl specific morpholino was used to reduce the function of Tbxl in zebrafish. The differentiation of the myocardial cells was observed using whole mount in situ hybridization. Heart rates were observed and recorded under the microscope from 24 to 72 hours post fertilization (hpf). The cardiac performance was analyzed by measuring ventricular shortening fraction and atrial shortening fraction.Results Tbxl morpholino injected embryos were characterized by defects in the pharyngeal arches, otic vesicle, aortic arches and thymus. In addition, Tbxl knock down reduced the amount of pharyngeal neural crest cells in zebrafish. Abnormal cardiac morphology was visible in nearly 20% of the Tbxl morpholino injected embryos. The hearts in these embryos did not loop or loop incompletely. Importantly, cardiac performance and heart rate were reduced in Tbxl morpholino injected embryos.Conclusions Tbxl might play an essential role in the development of pharyngeal neural crest cells in zebrafish. Cardiac performance is impaired by Tbxl knock down in zebrafish.

  10. Terpineol as a novel octane booster for extending the knock limit of gasoline

    KAUST Repository

    Vallinayagam, R.

    2016-09-16

    Improving the octane number of gasoline offers the potential of improved engine combustion, as it permits spark timing advancement without engine knock. This study proposes the use of terpineol as an octane booster for gasoline in a spark ignited (SI) engine. Terpineol is a bio-derived oxygenated fuel obtained from pine tree resin, and has the advantage of higher calorific value than ethanol. The ignition delay time (IDT) of terpineol was first investigated in an ignition quality tester (IQT). The IQT results demonstrated a long ignition delay of 24.7 ms for terpineol and an estimated research octane number (RON) of 104, which was higher than commercial European (Euro V) gasoline. The octane boosting potential of terpineol was further investigated by blending it with a non-oxygenated gasoline (FACE F), which has a RON (94) lower than Euro V gasoline (RON = 97). The operation of a gasoline direct injection (GDI) SI engine fueled with terpineol-blended FACE F gasoline enabled spark timing advancement and improved engine combustion. The knock intensity of FACE F + 30% terpineol was lower than FACE F gasoline at both maximum brake torque (MBT) and knock limited spark advance (KLSA) operating points. Increasing proportions of terpineol in the blend caused peak heat release rate, in-cylinder pressure, CA50, and combustion duration to be closer to those of Euro V gasoline. Furthermore, FACE F + 30% terpineol displayed improved combustion characteristics when compared to Euro V gasoline. © 2016

  11. Application of microwave digestion/AAS in detecting crankshaft bearing knock.

    Science.gov (United States)

    Chen, Li-dan; Zhao, Yan-ru

    2014-06-01

    The present study was carried out to detect crankshaft bearing knock using atomic absorption spectrometry (AAS) in an innovative way. Lubricating oil of MAGOTAN 2.0 with mileage of 1000-28000Km and sampling interval of 1000Km changed into atomic vapor in the heat after digesting with microwave. Hollow --cathode lamp made of the same element with metal content under test would radiate characteristic radiation with certain wavelength. A part of atomic vapor was launched with ground state atom after heating with graphite furnace. Concentration-absorbance working curve was finished with standard series sample after absorbance was measured. Finally, element content under test in oil was obtained based on the work curve. Database of primary element (Cu and Pb) content of lubricating oil in the same engine with different mileage was established. Results showed that Cu, Pb content fluctuates with different mileage in a certain range. In practical engineering applications, primary metal content in lubricating oil of engine crankshaft bearing was measured and compared with content variation trend chart. This new method not only helps automobile maintenance personnel to diagnose crankshaft bearing knock under no-disintegration situation but also is benefit for reducing the maintenance cost of automobile greatly and improving diagnostic accuracy of crankshaft bearing knock.

  12. Development definition of strength and anaerobic abilities in jump tests: classification, methodology of measuring and norms of estimation of standing high jump

    Directory of Open Access Journals (Sweden)

    Leonid Serhiyenko

    2015-10-01

    Full Text Available Purpose: to define the methodology of carrying out the tests: standing high jump and to systematize the general notion about measuring of strength and anaerobic human abilities. Material and Methods: methods of theoretic analysis and generalization, method of search and study of scientific information were used. Results: the standing high jump classification which helps to differentiate jumps according to the way of fulfillment and estimation of the development of motor abilities ware founded. Conclusion: the methodology of doing different kinds of jumps is described

  13. Establishment of expanded and streamlined pipeline of PITCh knock-in - a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO.

    Science.gov (United States)

    Nakamae, Kazuki; Nishimura, Yuki; Takenaga, Mitsumasa; Nakade, Shota; Sakamoto, Naoaki; Ide, Hiroshi; Sakuma, Tetsushi; Yamamoto, Takashi

    2017-05-04

    The emerging genome editing technology has enabled the creation of gene knock-in cells easily, efficiently, and rapidly, which has dramatically accelerated research in the field of mammalian functional genomics, including in humans. We recently developed a microhomology-mediated end-joining-based gene knock-in method, termed the PITCh system, and presented various examples of its application. Since the PITCh system only requires very short microhomologies (up to 40 bp) and single-guide RNA target sites on the donor vector, the targeting construct can be rapidly prepared compared with the conventional targeting vector for homologous recombination-based knock-in. Here, we established a streamlined pipeline to design and perform PITCh knock-in to further expand the availability of this method by creating web-based design software, PITCh designer ( http://www.mls.sci.hiroshima-u.ac.jp/smg/PITChdesigner/index.html ), as well as presenting an experimental example of versatile gene cassette knock-in. PITCh designer can automatically design not only the appropriate microhomologies but also the primers to construct locus-specific donor vectors for PITCh knock-in. By using our newly established pipeline, a reporter cell line for monitoring endogenous gene expression, and transgenesis (TG) or knock-in/knockout (KIKO) cell line can be produced systematically. Using these new variations of PITCh, an exogenous promoter-driven gene cassette expressing fluorescent protein gene and drug resistance gene can be integrated into a safe harbor or a specific gene locus to create transgenic reporter cells (PITCh-TG) or knockout cells with reporter knock-in (PITCh-KIKO), respectively.

  14. Autonomous Rubidium Clock Weak Frequency Jump Detector for Onboard Navigation Satellite System.

    Science.gov (United States)

    Khare, Akshay; Arora, Rajat; Banik, Alak; Mehta, Sanjay D

    2016-02-01

    Frequency jumps are common in rubidium frequency sources. They affect the estimation of user position in navigational satellite systems. These jumps must be detected and corrected immediately as they have direct impact on the navigation system integrity. A novel weak frequency jump detector is proposed based on a Kalman filter with a multi-interval approach. This detector can be applied for both "sudden" and "slow" frequency transitions. In this detection method, noises of clock data are reduced by Kalman filtering, for accurate estimation of jump size with less latency. Analysis on in-orbit rubidium atomic frequency standard (RAFS) phase telemetry data shows that the detector can be used for fast detection and correction of weak frequency jumps. Furthermore, performance comparison of different existing frequency jump detection techniques with the proposed detector is discussed. A multialgorithm-based strategy is proposed depending on the jump size and latency for onboard navigation satellites having RAFS as the primary frequency source.

  15. Hotspot Cooling with Self-Propelled Jumping Condensate

    Science.gov (United States)

    Qu, Xiaopeng; Boreyko, Jonathan B.; Liu, Fangjie; Chen, Chuan-Hua

    2012-11-01

    Dynamic hotspots are prevalent in electronic systems including microprocessors and power electronics with constantly changing computing tasks or payloads. Here, we report a new adaptive hotspot cooling technique that rapidly responds to moving hotspots in a passive manner independent of external forces. The hotspot cooling is based upon the self-propelled jumping of dropwise condensate, which directly returns the working fluid from a superhydrophobic condenser to an opposing superhydrophilic evaporator. The adaptive thermal management is accomplished by the preferential evaporation of water at the hotspots and the rapid jumping return of the condensate across the very short inter-plate distance. The proof-of-concept for this hotspot cooling technique will be demonstrated by the adaptive response to hotspots at increasing heat fluxes. Corresponding author.

  16. VaR: Exchange Rate Risk and Jump Risk

    Directory of Open Access Journals (Sweden)

    Fen-Ying Chen

    2010-01-01

    Full Text Available Incorporating the Poisson jumps and exchange rate risk, this paper provides an analytical VaR to manage market risk of international portfolios over the subprime mortgage crisis. There are some properties in the model. First, different from past studies in portfolios valued only in one currency, this model considers portfolios not only with jumps but also with exchange rate risk, that is vital for investors in highly integrated global financial markets. Second, in general, the analytical VaR solution is more accurate than historical simulations in terms of backtesting and Christoffersen's independence test (1998 for small portfolios and large portfolios. In other words, the proposed model is reliable not only for a portfolio on specific stocks but also for a large portfolio. Third, the model can be regarded as the extension of that of Kupiec (1999 and Chen and Liao (2009.

  17. Control and filtering for semi-Markovian jump systems

    CERN Document Server

    Li, Fanbiao; Wu, Ligang

    2017-01-01

    This book presents up-to-date research developments and novel methodologies on semi-Markovian jump systems (S-MJS). It presents solutions to a series of problems with new approaches for the control and filtering of S-MJS, including stability analysis, sliding mode control, dynamic output feedback control, robust filter design, and fault detection. A set of newly developed techniques such as piecewise analysis method, positively invariant set approach, event-triggered method, and cone complementary linearization approaches are presented. Control and Filtering for Semi-Markovian Jump Systems is a comprehensive reference for researcher and practitioners working in control engineering, system sciences and applied mathematics, and is also a useful source of information for senior undergraduates and graduates in these areas. The readers will benefit from some new concepts, new models and new methodologies with practical significance in control engineering and signal processing.

  18. Pricing Asian power options under jump-fraction process

    Directory of Open Access Journals (Sweden)

    Bin Peng

    2012-12-01

    Full Text Available A framework for pricing Asian power options is developed when the underlying asset follows a jump-fraction process. The partial differential equation (PDE in the fractional environment with jump is constructed for such option using general Itô's lemma and self-financing dynamic strategy. With the boundary condition, an analytic formula for the option with geometric average starting at any time before maturity is derived by solving the PDE, and the option with arithmetic average is evaluated in Monte Carlo simulation using control variate technique with the help of the above analytic solution. Overwhelming numerical evidence indicates that the technique proposed is computationally efficient and dramatically improves the accuracy of the simulated price. Moreover, this study will pave a novel way to copy with the option contracts based on thinly-traded assets like oil, or currencies or interest rates.

  19. The circular jump as a hydrodynamic white hole

    CERN Document Server

    Jannes, Gil

    2012-01-01

    Surface waves in classical fluids experience a rich array of black/white hole horizon effects. The dispersion relation depends on the characteristics of the fluid as well as on the fluid depth and the wavelength regime. We focus on the shallow-water regime, and discuss the experimental proof that the circular hydraulic jump marks the transition between a supercritical and a subcritical flow regime. This finally confirms a theoretical conjecture formulated by Lord Rayleigh nearly 100 years ago. It also confirms that the circular jump corresponds to the spontaneous formation of a hydrodynamic white hole, with interesting characteristics from the point of view of analogue gravity. We study the dispersive regime, mention some lessons about the trans-Planckian issue and describe possible directions for future work.

  20. The asteroid belt outer region under jumping-Jupiter migration

    Science.gov (United States)

    Gaspar, H. S.; Winter, O. C.; Vieira Neto, E.

    2017-09-01

    The radial configuration of the outer region of the main asteroid belt is quite peculiar, and has much to say about the past evolution of Jupiter. In this work, we investigate the dynamical effects of a jumping-Jupiter-like migration over a more extended primordial asteroid belt. Jupiter's migrations are simulated using a fast jumping-Jupiter synthesizer. Among the results, we highlight non-negligible fractions of primordial objects trapped in 3:2 and 4:3 mean motion resonances (MMRs) with Jupiter. They survived the whole truculent phase of migration and originated populations that are like Hildas and Thules. Fractions ranging from 3 to 6 per cent of the initial distribution remained trapped in 3:2 MMR, and at least 0.05 per cent in 4:3. These results show that the resonance trapping of primordial objects may have originated these resonant populations. This theory is consistent even for Jupiter's truculent evolution.