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Sample records for julius gy fabos

  1. Julius Petersen 1839-1910. A Biography

    DEFF Research Database (Denmark)

    Lützen, Jesper; Sabidussi, Gert; Toft, Bjarne

    1992-01-01

    A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics.......A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics....

  2. Authenticating the writings of Julius Caesar

    NARCIS (Netherlands)

    Kestemont, Mike; Stover, Justin; Koppel, Moshe; Karsdorp, F.B.; Daelemans, Walter

    2016-01-01

    In this paper, we shed new light on the authenticity of the Corpus Caesarianum, a group of five commentaries describing the campaigns of Julius Caesar (100–44 BC), the founder of the Roman empire. While Caesar himself has authored at least part of these commentaries, the authorship of the rest of th

  3. Authenticating the writings of Julius Caesar

    NARCIS (Netherlands)

    Kestemont, Mike; Stover, Justin; Koppel, Moshe; Karsdorp, F.B.; Daelemans, Walter

    2016-01-01

    In this paper, we shed new light on the authenticity of the Corpus Caesarianum, a group of five commentaries describing the campaigns of Julius Caesar (100–44 BC), the founder of the Roman empire. While Caesar himself has authored at least part of these commentaries, the authorship of the rest of

  4. La producción literaria del P. Fabo de María:Una aproximación a la temática americana

    Directory of Open Access Journals (Sweden)

    Carlos Mata Induráin

    2006-01-01

    Full Text Available Este trabajo constituye una aproximación a la presencia de temasamericanos en la producción literaria del P. Fabo de María, sacerdotenavarro que desarrolló su trabajo misional en Colombia. Seanaliza, especialmente, la presencia de los indígenas colombiano

  5. Gaudeamus. Het leven van Julius Röntgen (1855-1932). Componist en musicus

    NARCIS (Netherlands)

    Vis, G.N.M.

    2007-01-01

    Gaudeamus Het leven van Julius Röntgen (1855-1932) Componist en musicus Jurjen Vis shows in his thesis Gaudeamus. The life of Julius Röntgen (1855-1932) that already as a young child Julius Röntgen was a remarkable pianist and composer. He was hailed at that time as a second Mendelssohn. In 1874 Rön

  6. A brief account of Julius Planer's life and research

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    R. Bilyy

    2010-01-01

    Full Text Available A brief account of the life and research activities of Julius Planer is presented. Professor Planer is a scientist who lived one and half century ago. However, his studies, in particular, during the years when he headed Department of Anatomy at Universität in Lemberg, nowadays known as the Ivan Franko National University of Lviv in Ukraine, were essential to a modern understanding of liquid crystals. While working at Lviv University, Planer also made several landmark contributions to biomedical science.

  7. Julius von Schlosser and the need to reminisce

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    Karl Johns

    2009-12-01

    Full Text Available In the present essay of 1936, Julius Schlosser seems to have originated the term of ‘die Wiener Schule de Kunstgeschichte’. After surviving a period of exasperating rivalry with Josef Strzygowski, seeing so many colleagues go to their graves before completing their favorite projects, and possibly since Wilhelm Waetzoldt decided to omit Austrians from his Deutsche Kunsthistoriker, there were several reasons for a man of his age, experience and critical vigor to take stock of a development which seemed to be heading into an uncertain future.

  8. Julius Sachs (1832-1897) and the Unity of Life.

    Science.gov (United States)

    Kutschera, Ulrich; Baluška, František

    2015-01-01

    In 1865, the German botanist Julius Sachs published a seminal monograph entitled Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) and hence became the founder of a new scientific discipline that originated 150 y ago. Here, we outline the significance of the achievements of Sachs. In addition, we document, with reference to his Vorlesungen über Pflanzen-Physiologie (Lectures on the Physiology of Plants, 1882), that Sachs was one of the first experimentalists who proposed the functional unity of all organisms alive today (humans, animals, plants and other "vegetable" organisms, such as algae, cyanophyceae, fungi, myxomycetes, and bacteria).

  9. Julius Von Bismark and Self-absorption without Stigmas

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    Clara Zarza

    2015-11-01

    Full Text Available El pasado mes de junio, la galería Marlborough Chelsea presentaba en el  pabellón de Unlimited de la 46.ª edición de la Feria de Arte de Basilea una enorme performance-instalación del artista alemán Julius von Bismarck. La obra, titulada Egocentric System, presentaba un llamativo hábitat de cemento a modo de gran antena parabólica giratoria donde Von Bismark dormía, comía o escribía en su ordenador y hablaba por teléfono durante los días de la feria. Su presencia en el contexto institucional de la feria, la enorme atención del público y de la prensa parecen incidir en un cambio en la recepción de obras autorrepresentativas que exploran el mundo privado o la experiencia personal.

  10. Noncommutativity and Humanity -- Julius Wess and his Legacy

    CERN Document Server

    Djordjevic, Goran S

    2014-01-01

    A personal view on Julius Wess's human and scientific legacy in Serbia and the Balkan region is given. Motivation for using noncommutative and nonarchimedean geometry on very short distances is presented. In addition to some mathematical preliminaries, we present a short introduction in adelic quantum mechanics in a way suitable for its noncommutative generalization. We also review the basic ideas and tools embedded in $q$-deformed and noncommutative quantum mechanics. A rather fundamental approach, called deformation quantization, is noted. A few relations between noncommutativity and nonarchimedean spaces, as well as similarities between corresponding quantum theories, in particular, quantum cosmology are pointed out. An extended Moyal product in a frame of an adelic noncommutative quantum mechanics is also considered.

  11. Julius – a template based supplementary electronic health record system

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    Klein Gunnar O

    2007-05-01

    Full Text Available Abstract Background EHR systems are widely used in hospitals and primary care centres but it is usually difficult to share information and to collect patient data for clinical research. This is partly due to the different proprietary information models and inconsistent data quality. Our objective was to provide a more flexible solution enabling the clinicians to define which data to be recorded and shared for both routine documentation and clinical studies. The data should be possible to reuse through a common set of variable definitions providing a consistent nomenclature and validation of data. Another objective was that the templates used for the data entry and presentation should be possible to use in combination with the existing EHR systems. Methods We have designed and developed a template based system (called Julius that was integrated with existing EHR systems. The system is driven by the medical domain knowledge defined by clinicians in the form of templates and variable definitions stored in a common data repository. The system architecture consists of three layers. The presentation layer is purely web-based, which facilitates integration with existing EHR products. The domain layer consists of the template design system, a variable/clinical concept definition system, the transformation and validation logic all implemented in Java. The data source layer utilizes an object relational mapping tool and a relational database. Results The Julius system has been implemented, tested and deployed to three health care units in Stockholm, Sweden. The initial responses from the pilot users were positive. The template system facilitates patient data collection in many ways. The experience of using the template system suggests that enabling the clinicians to be in control of the system, is a good way to add supplementary functionality to the present EHR systems. Conclusion The approach of the template system in combination with various local EHR

  12. Study Protocol: A randomized controlled trial evaluating the effect of family-based behavioral treatment of childhood and adolescent obesity-The FABO-study.

    Science.gov (United States)

    Skjåkødegård, Hanna F; Danielsen, Yngvild S; Morken, Mette; Linde, Sara-Rebekka F; Kolko, Rachel P; Balantekin, Katherine N; Wilfley, Denise E; Júlíusson, Pétur B

    2016-10-21

    The purpose of the FABO-study is to evaluate the effect of family-based behavioral social facilitation treatment (FBSFT), designed to target children's family and social support networks to enhance weight loss outcomes, compared to the standard treatment (treatment as usual, TAU) given to children and adolescents with obesity in a routine clinical practice. Randomized controlled trial (RCT), in which families (n = 120) are recruited from the children and adolescents (ages 6-18 years) referred to the Obesity Outpatient Clinic (OOC), Haukeland University Hospital, Norway. Criteria for admission to the OOC are BMI above the International Obesity Task Force (IOTF) cut-off ≥ 35, or IOTF ≥ 30 with obesity related co-morbidity. Families are randomized to receive FBSFT immediately or following one year of TAU. All participants receive a multidisciplinary assessment. For TAU this assessment results in a plan and a contract for chancing specific lifestyle behaviors. Thereafter each family participates in monthly counselling sessions with their primary health care nurse to work on implementing these goals, including measuring their weight change, and also meet every third month for sessions at the OOC. In FBSFT, following assessment, families participate in 17 weekly sessions at the OOC, in which each family works on changing lifestyle behaviors using a structured cognitive-behavioral, socio-ecological approach targeting both parents and children with strategies for behavioral maintenance and sustainable weight change. Outcome variables include body mass index (BMI; kg/m(2)), BMI standard deviation score (SDS) and percentage above the IOTF definition of overweight, waist-circumference, body composition (bioelectric impedance (BIA) and dual-X-ray-absorptiometry (DXA)), blood tests, blood pressure, activity/inactivity and sleep pattern (measured by accelerometer), as well as questionnaires measuring depression, general psychological symptomatology, self

  13. Karl Julius Lohnert - an unknown astronomer, experimental psychologist and teacher (German Title: Karl Julius Lohnert - ein unbekannter Astronom, experimenteller Psychologe und Lehrer)

    Science.gov (United States)

    Schmadel, Lutz D.; Guski-Leinwand, Susanne

    2011-08-01

    Karl Julius Lohnert (1885-1944) with his double biography as astronomer and psychologist is hardly known in both fields. As a student of astronomy in Heidelberg, Lohnert discovered a couple of minor planets and he dedicated one to his PhD supervisor, the famous Leipzig professor for philosophy, Wilhelm Wundt. This connection is discussed for the first time almost one century after the naming of (635) Vundtia. The paper elucidates some biographical stations of Lohnert.

  14. On Julius Planer's 1861 paper "Notiz über das Cholestearin" in Annalen der Chemie und Pharmacie

    Directory of Open Access Journals (Sweden)

    A. Trokhymchuk

    2010-01-01

    Full Text Available Brief review of the literature on the history of thermotropic liquid crystal discovery and the role of the observations reported by Julius Planer in his note published almost 150 years ago.

  15. Julius Wellhausen � die denke van �n Ou-Testamentikus

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    Gideon J. Serfontein

    2012-02-01

    Full Text Available Julius Wellhausen � the thoughts of an Old Testament scholar. The purpose of this article is to examine the life, influence and greatest works of Old Testament scholar Julius Wellhausen. Wellhausen was influenced by the findings of other Old Testament critics that preceded him, as well as the new environment that the Enlightenment has created. These influences can be seen in his three major works: Die Komposition des Hexateuchs � here an idea of the method he used in the recognition, grouping and dating of the sources can be found. Wellhausen made use of these sources to construct a history of Israel which can be viewed in his Geschichte Israels. His greatest work was most certainly his Prolegomena zur Geschichte Israels and he makes significant findings in the part on the Geschichte des Kultus. The question to be answered though is: Does Wellhausen�s source hypothesis still has a part to play in our modern research on the Pentateuch?

  16. Art and science interactions - First Collide @CERN public lecture by Julius Von Bismarck

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Creative collisions between the arts and science have begun at CERN with the first Collide@CERN artist, Julius Von Bismarck starting his digital arts residency at the world's largest particle physics laboratory outside Geneva. He was chosen from 395 entries from 40 countries around the world from the Prix Ars Electronica Collide@CERN competition launched last September 2011. To mark this special occasion, the first Collide@CERN public lecture open to everyone will take place on March 21st 2012 at CERN's Globe of Science and Innovation, with a drinks reception at 18.45 and with presentations starting at 19.30. The event is free and will be opened by the Director General of CERN, Professor Rolf-Dieter Heuer and Gerfried Stocker, the Artistic Director of Ars Electronica, Linz, - CERN's international cultural partners for the digital arts Collide@CERN award known as Prix Ars Electronica Collide@CERN in recognition of our joint partnership. Julius Von Bismarck and his CERN science inspiration partner, the physic...

  17. Light and collisions: Julius von Bismark presents an update on his work after his CERN Residency

    CERN Multimedia

    2012-01-01

    On 27 June 2012, Julius von Bismarck, the first winner of the Prix Ars Electronica Collide@CERN, will give a special informal interim lecture for CERN on his ideas and work in progress.   Julius will disclose his personal reactions to his experiences at CERN, sharing with us how particle physics and the laboratory has started having an impact on his artistic practice. As he said when he won the prize at the first Collide@CERN public lecture: “For me, the Collide@CERN residency is a dream come true.” So has reality matched up with his dreams? And why in the first two weeks did he say: “For me already the residency is already a success.” What is his experience of the creative collisions between arts and science? There will be opportunities for the audience to ask questions, and the artist stresses that this will be a personal and informal presentation of ideas in progress. The lecture will take place in the Council Chamber (Room 503-1-001) from 4.3...

  18. Julius von Schlosser on Vasari: a translation from Die Kunstliteratur (1924

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    Karl Johns

    2010-06-01

    Full Text Available Although Julius Schlosser is well known by name and as a source for bibliographical references, very few art historians are familiar with the substance of his forty year teaching career which inspired the likes of Kris, Kurz, Bodonyi, Gombrich and many others. Die Kunstliteratur of 1924 became his fifth and final such handbook, and was published with the intention to elucidate the pre-history of the history of art as an academic discipline. It is natural that Giorgio Vasari has a place at the core of such a story. However, Schlosser possessed an unrivalled knowledge of the relevant written and theoretical sources, and his unusually consistent approach found Lorenzo Ghiberti to be the actual founder of the subject and Winckelmann to have finally overcome the relatively pernicious influence of Vasari. This chapter from the centre of his book therefore still today remains the best critical account of Vasari’s writings from a broader point of view.

  19. Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now.

    Science.gov (United States)

    Nattie, Eugene

    2011-01-01

    The 2010 Julius H. Comroe, Jr., Lecture of the American Physiological Society focuses on evolving ideas in chemoreception for CO₂/pH in terms of what is "sensed," where it is sensed, and how the sensed information is used physiologically. Chemoreception is viewed as involving neurons (and glia) at many sites within the hindbrain, including, but not limited to, the retrotrapezoid nucleus, the medullary raphe, the locus ceruleus, the nucleus tractus solitarius, the lateral hypothalamus (orexin neurons), and the caudal ventrolateral medulla. Central chemoreception also has an important nonadditive interaction with afferent information arising at the carotid body. While ventilation has been viewed as the primary output variable, it appears that airway resistance, arousal, and blood pressure can also be significantly affected. Emphasis is placed on the importance of data derived from studies performed in the absence of anesthesia.

  20. Julius Elster and Hans Geitel - Dioscuri of physics and pioneer investigators in atmospheric electricity

    Science.gov (United States)

    Fricke, Rudolf G. A.; Schlegel, Kristian

    2017-01-01

    Julius Elster and Hans Geitel contributed to the physics at the turn of the 19-20th century in many ways. We first summarize the life of these exceptional scientists. Then - owing to the topic of this journal - we focus on their atmospheric electricity research. With their experiments, careful evaluations and ingenious interpretation, Elster and Geitel made important contributions to precipitation electricity, the influence of solar radiation on the electric state of the atmosphere, the nature of charge carriers and the ionization of air by radioactivity. They proved their experimental skills by inventing new instruments with unprecedented accuracy and reliability. A very modern concept was their attitude to undertake long-term measurements at various locations. A section on their recognition in the physics community and their scientific distinctions concludes the paper.

  1. Scripture in the Sky: Jeremias Drexel, Julius Schiller, and the Christianizing of the Constellations

    Science.gov (United States)

    Mendillo, M.; Shapiro, A.

    2011-06-01

    From the times of early Christians up to the Enlightenment, the twelve ancient signs of the zodiac were challenged as highly inappropriate pagan images. The most concerted efforts to replace those signs with names, mottos, and images taken from Holy Scripture occurred in the early decades of the 17th century. We review the background that led to the proposed use of sacred mottos by Jeremias Drexel, and then of the names and images of the Twelve Apostles by Julius Schiller. The reaction of a leading seventeenth-century astronomer is presented to suggest why such changes were never adopted. Finally, we address issues of conflict and motivation that might have led to efforts to Christianize the Heavens.

  2. Atmosphere-Ionosphere Coupling due to Atmospheric Tides (Julius Bartels Medal Lecture)

    Science.gov (United States)

    Forbes, Jeffrey M.

    2016-04-01

    Within the last decade, a new realization has arrived on the scene of ionosphere-thermosphere (IT) science: terrestrial weather significantly influences space weather. The aspect of space weather referred to here consists of electron density variability that translates to uncertainties in navigation and communications systems, and neutral density variability that translates to uncertainties in orbital and reentry predictions. In the present context "terrestrial weather" primarily refers to the meteorological conditions that determine the spatial-temporal distribution of tropospheric water vapor and latent heating associated with tropical convection, and the middle atmosphere disturbances associated with sudden stratosphere warmings. The net effect of these processes is a spatially- and temporally-evolving spectrum of waves (gravity waves, tides, planetary waves, Kelvin waves) that grows in amplitude with height and enters the IT system near ~100 km. Some members of the wave spectrum penetrate all the way to the base of the exosphere (ca. 500 km). Along the way, nonlinear interactions between different wave components occur, modifying the interacting waves and giving rise to secondary waves. Finally, the IT wind perturbations carried by the waves can redistribute ionospheric plasma, either through the electric fields generated via the dynamo mechanism between 100 and 150 km, or directly by moving plasma along magnetic field lines at higher levels. Additionally, the signatures of wave-driven dynamo currents are reflected in magnetic perturbations observed at the ground. This is how terrestrial atmospheric variability, through the spectrum of vertically- propagating waves that it produces, can effectively drive IT space weather. The primary objective of this Julius Bartels Lecture is to provide an overview of the global observational evidence for the IT consequences of these upward-propagating waves. In honor of Julius Bartels, who performed much research (including

  3. Early Conquest of the Rock: Julius Lempert's Life and the Complete Apicectomy Technique for the Treatment of Suppurative Petrous Apicitis

    OpenAIRE

    Khaled M. Krisht; Shelton, Clough; Couldwell, William T.

    2014-01-01

    Julius Lempert (1891–1968) was one of the most revolutionary and innovative neuro-otologists of the 20th century. He had a remarkable role in advancing the field of otolaryngology to its modern shape and form, especially through his groundbreaking introduction of the fenestration procedure for the treatment of otosclerosis. Although he is highly celebrated by many neuro-otologists for his contributions to our surgical and anatomical understanding of the petrous bone, he is not well known to t...

  4. Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.

    Science.gov (United States)

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).

  5. Julius König et les Principes Aristotéliciens

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    Marcel Guillaume

    2009-08-01

    Full Text Available In his posthumous book from 1914, “New foundations of logic, arithmetic andset theory”, Julius König develops his philosophy of mathematics. In a previous contribution, we attracted attention on the positive part (his truth and falsehood predicates being excluded of his “pure logic”: his “isology” being assimilated to mutual implication, it constitutes a genuine formalization of positive intuitionistic logic. König’s intention was to rebuild logic in such a way that the excluded third’s principle could no longer be logical. However, his treatment of truth and falsehood (boiling down to negation is purely classical. We explain here this discrepancy by the choice of the alleged more primitive notions to which the questioned notions of truth and falsehood have been reduced. Finaly, it turns out that the disjunctive and conjunctive forms of the principles of the excluded third and of contradiction have effectively been excluded, but none of their implicative forms.

  6. VERBAL POWER DUEL: VERBAL COMBAT STRATEGIES IN SHAKESPEARE'S JULIUS CAESAR:BRUTUS VERSUS ANTONY

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    AYDIN BEHNAM

    2009-01-01

    Full Text Available In A Glossary of Contemporary Literary Theory, Jeremy Hawthorn refers to Cultural Materialism as an "umbrella term" that allows itself the opulence to utilise a wide range of tools and theories from many different disciplines. This allows us to justify the nature of both commonly acknowledged and abstruse socio-cultural episteme and discourse, one of the most prominent of which is the issue of power and power relations.This paper, which was originally part of a larger body of work on Cultural Materialism, tries to draw upon a few different theories to examine the confrontational relationship that exists between the two prominent characters of Shakespeare's (1953 Julius Caesar (namely Antony and Brutus, as represented by the duel-like orations of the two characters. The main goal of the paper is to demonstrate how Antony is able to manipulate the words of Brutus against him and thus succeed in captivating the crowd.The theoretical discussions drawn upon in this article will include Austin's (1999 ideas on language as action, Bourdieu's (1999 argument of dialogue as contest and Hutchby's (1999 findings on turn-taking strategies. This paper will also incorporate Paul Grice's Cooperative Principle, introduced in his "Logic and Conversation" (1999. This principle argues that the flouting of any of Grice's four maxims by the characters is meaningful and effective because it introduces an "implicature" in the political and social context in which the pieces of discourse take place.

  7. Dictator Perpetuus: Julius Caesar--did he have seizures? If so, what was the etiology?

    Science.gov (United States)

    Hughes, John R

    2004-10-01

    The "Dictator Perpetuus" of the Roman Empire, the great Julius Caesar, was not the one for whom the well-known cesarean operation was named; instead, this term is derived from a Latin word meaning "to cut." Caesar likely had epilepsy on the basis of four attacks that were probably complex partial seizures: (1) while listening to an oration by Cicero, (2) in the Senate while being offered the Emperor's Crown, and in military campaigns, (3) near Thapsus (North Africa) and (4) Corduba (Spain). Also, it is possible that he had absence attacks as a child and as a teenager. His son, Caesarion, by Queen Cleopatra, likely had seizures as a child, but the evidence is only suggestive. His great-great-great grandnephews Caligula and Britannicus also had seizures. The etiology of these seizures in this Julio-Claudian family was most likely through inheritance, with the possibility of sudden unexpected death in epilepsy (SUDEP) in his great grandfather and also his father. Our best evidence comes from the ancient sources of Suetonius, Plutarch, Pliny, and Appianus.

  8. Rhetorical Flaws in Brutus’ Forum Speech in Julius Caesar: A Carefully Controlled Weakness?

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    Dominic Cheetham

    2017-06-01

    Full Text Available In Julius Caesar Shakespeare reproduces one of the pivotal moments in European history. Brutus and Mark Antony, through the medium of their forum speeches, compete for the support of the people of Rome. In the play, as in history, Mark Antony wins this contest of language. Critics are generally agreed that Antony has the better speech, but also that Brutus’ speech is still exceptionally good. Traditionally the question of how Antony’s speech is superior is argued by examining differences between the two speeches, however, this approach has not resulted in any critical consensus. This paper takes the opening lines of the speeches as the only point of direct convergence between the content and the rhetorical forms used by Brutus and Antony and argues that Brutus’ opening tricolon is structurally inferior to Marc Antony’s. Analysis of the following rhetorical schemes in Brutus’ speech reveals further structural weaknesses. Shakespeare gives Brutus a speech rich in perceptually salient rhetorical schemes but introduces small, less salient, structural weaknesses into those schemes. The tightly structured linguistic patterns which make up the majority of Brutus’ speech give an impression of great rhetorical skill. This skilful impression obscures the minor faults or weaknesses that quietly and subtly reduce the overall power of the speech. By identifying the weaknesses in Brutus’ forms we add an extra element to the discussion of these speeches and at the same time display how subtly and effectively Shakespeare uses rhetorical forms to control audience response and appreciation.

  9. Julius von Schlosser: aesthetics, art history and the book’, Report on the 150th Anniversary Conference on Julius von Schlosser, 6th and 7th October 2016: Julius von Schlosser (1866–1938, Internationale Tagung zum 150. Geburtstag, gemeinsam veranstaltet vom Kunsthistorischen Museum Wien und dem Institut für Kunstgeschichte der Universität Wien

    Directory of Open Access Journals (Sweden)

    Matthew Rampley

    2016-12-01

    Full Text Available This report provides an overview of the main themes and questions explored at the conference held in Vienna on the 150th anniversary of the birth of Julius von Schlosser. It considers in particular his attempts to address the challenges presented by what he regarded as the primacy of the aesthetic artefact in art historical discourse. It presents the broader interests of Schlosser’s diverse oeuvre, which ranged from the study of musical instruments and collecting to medieval art and the literature on art.

  10. Explaining the unusual line profiles of SN 2006gy

    Science.gov (United States)

    Chugai, Nikolai N.

    2017-02-01

    This paper explores the origin of the enigmatic line profiles of the extremely luminous Type IIn supernova, SN 2006gy, on day 96. Among the conceivable possibilities, the most preferred is the model that suggests there are holes in the optically thick cool dense shell (CDS). The line radiation emitted at the inner side of the opaque CDS escapes through the holes, thus producing an unusual line profile with the emission shifted redward. The holes could emerge as a result of the vigorous Rayleigh-Taylor instability, leading to the CDS fragmentation. The model light curve with the CDS fragmentation is shown to be consistent with the SN 2006gy bolometric light curve.

  11. Explaining unusual line profiles of SN 2006gy

    CERN Document Server

    Chugai, Nikolai

    2016-01-01

    Origin of enigmatic line profiles of extremely luminous type IIn supernova SN~2006gy on day 96 is explored. Among conceivable possibilities the most preferred is the model that suggests holes in the optically thick cool dense shell (CDS). The line radiation emitted at the inner side of the opaque CDS escapes through the holes thus producing unusual line profile with the emission shifted redward. The holes could emerge as a result of a vigorous Rayleigh-Taylor instability leading to the CDS fragmentation. The model light curve with the CDS fragmentation is shown to be consistent with the SN~2006gy bolometric light curve.

  12. [Julius Ludwig August Koch (1841-1908). Psychiatrist, philosopher, and Christian].

    Science.gov (United States)

    Gutmann, Philipp

    2006-01-01

    Julius Ludwig August Koch was born 1841 in the small town of Laichingen (Württemberg) in the Southwest of Germany. After working as a chemist for about seven years, he studied medicine in Tübingen from 1863 to 1867. First he worked as a physican and later in a private mental hospital in Göppingen. From 1874 to 1898, he was director of a state mental hospital in Zwiefalten (Württemberg). Koch died in 1908 after a long period of suffering in Zwiefalten. Being deeply routed in a Christian faith and having much interest in moral and ethical issues, Koch published some philosophical works 'Epistomological investigations' (Erkenntnistheoretische Untersuchungen, 1882), 'Outline of philosophy' (Grundriss der Philosophie, 1885) and 'Reality and its knowledge' (Die Wirklichkeit und ihre Erkenntnis, 1886). In this papers he tried to bring together critical Kantian philosophy and Christian conviction. In 1888 he published a 'Short Textbook of Psychiatry' (Kurzgefasster Leitfaden der Psychiatrie), where he mentioned the term "psychopathic inferiority" for the first time (Psychopathische Minderwertigkeiten). The following work, focussing on this issue with the title 'Psychopathic Inferiority' (Die psychopathischen Minderwertigkeiten, 1891-1893), became one of the fundamental texts concerning the concept of disorders of personality, which are in use today. In this book, published in three parts, he tried to describe the hole field between psychic normality and psychoses. Only the first and biggest part deals with psychopathological symptoms which we now think to be essential for personality disorders. Koch differentiates between "disposition" (Disposition), "burden" (Belastung) and "degeneration" (Degeneration), assuming a graduation. "Disposition" should be the mildest disorder, turning into normality, whereas "degeneration" turns to psychosis. Koch believed, that on the basis of all degrees of "psychpathic inferiority" there was a congenital defect of the constitution of

  13. Dose reduction trial from 60 Gy in 10 fractions to 54 Gy in 9 fractions schedule in high-dose-rate interstitial brachytherapy for early oral tongue cancer

    Science.gov (United States)

    Akiyama, Hironori; Yoshida, Ken; Shimizutani, Kimishige; Yamazaki, Hideya; Koizumi, Masahiko; Yoshioka, Yasuo; Kakimoto, Naoya; Murakami, Shumei; Furukawa, Souhei; Ogawa, Kazuhiko

    2012-01-01

    To compare the effects of 60 Gy/10 fractions (twice a day) with those of 54 Gy/9 fractions in high-dose-rate interstitial brachytherapy (HDR-ISBT) for early tongue cancer, we performed a matched-pair analysis of patients with early tongue cancer (T1-2N0M0), who were treated with 60 or 54 Gy of radiation between 1996 and 2004. Seventeen patients treated with 54 Gy and 34 matched-pair patients treated with 60 Gy were extracted and analyzed. Local recurrence occurred in two patients in the 54-Gy arm and five patients in the 60-Gy arm. The 2-year local control rates were 88% for both the 54-Gy arm and 60-Gy arm (not significant). The 2-year overall survival rates were 88% in the 60-Gy arm and 82% in the 54-Gy arm. Two-year actuarial complication-free rates were 91% in the 60-Gy arm and 83% in the 54-Gy arm (not significant), respectively. There was no significant association between the total dose and local control rate and late complications. The outcome of 54 Gy/ 9 fractions was similar to that of 60 Gy/ 10 fractions in patients with early tongue cancer. PMID:22843365

  14. Biodegradation polyurethane derived from vegetable oil irradiated with gamma rays 25 kGy and 100 kGy; Biodegradacao de poliuretano derivado de oleo vegetal irradiado com raios gama 25 kGy e 100 kGy

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Antonia M. dos, E-mail: amsantos@rc.unesp.br [Universidade Estadual Paulista - Unesp, Rio Claro, SP (Brazil); Claro Neto, Salvador [Universidade de Sao Paulo - USP, Campus de Sao Carlos, SP (Brazil); Azevedo, Elaine C. de [Universidade Federal do Parana, Campus de Curitiba, PR (Brazil)

    2011-07-01

    The environment requires polymers that can be degraded by the action of microorganisms. In this work was studied the biodegradation of polyurethane samples derived from vegetable oil (castor oil), which were irradiated with gamma rays 25 kGy and 100 kGy compared with the same polyurethane without being irradiated. Biodegradation of polyurethane was carried out in culture medium containing the fungus Aspergillus niger by 146 days and the result was evaluated using the technique of thermogravimetric analysis, where there was a change of behavior of the curves TGA / DTG occurred indicating that chemical modifications of molecules present in the structure of the polymer chain, thus confirming that the material has undergone the action of microorganisms. (author)

  15. Teleotemporalidad: un nivel de estudio adicional para la organización derivado del modelo de Julius Thomas Fraser

    Directory of Open Access Journals (Sweden)

    Claudio Mera Ruiz

    2016-02-01

    Full Text Available Este artículo propone la teleotemporalidad como un nuevo espacio de análisis de la organización derivado de la consideración del modelo de Julius Thomas Fraser. Para desarrollar la propuesta, se sintetiza el trabajo de Fraser, que está compuesto por seis niveles de estudio de la temporalidad: 1 atemporalidad, que toca los fenómenos electromagnéticos; 2 prototemporalidad, que explica el comportamiento molecular; 3 eotemporalidad, que se ocupa de la mecánica clásica; 4 biotemporalidad, que atañe al comportamiento de los seres vivos; 5 nootemporalidad, que explica la experiencia humana, y 6 sociotemporalidad, sobre los fenómenos sociales del tiempo. Por último, se explica la teleotemporalidad como un nuevo espacio de análisis útil para aproximarse a la comprensión de la temporalidad organizacional.

  16. Early Conquest of the Rock: Julius Lempert's Life and the Complete Apicectomy Technique for the Treatment of Suppurative Petrous Apicitis.

    Science.gov (United States)

    Krisht, Khaled M; Shelton, Clough; Couldwell, William T

    2015-03-01

    Julius Lempert (1891-1968) was one of the most revolutionary and innovative neuro-otologists of the 20th century. He had a remarkable role in advancing the field of otolaryngology to its modern shape and form, especially through his groundbreaking introduction of the fenestration procedure for the treatment of otosclerosis. Although he is highly celebrated by many neuro-otologists for his contributions to our surgical and anatomical understanding of the petrous bone, he is not well known to the neurosurgical community. In this article, we give a detailed account of Dr. Lempert's life and discuss his invaluable contribution to skull base petrous bone anatomy and surgery through his pioneering work on the complete apicectomy for the treatment of suppurative petrous apicitis.

  17. [A biographical sketch of Albert Szent-Györgyi].

    Science.gov (United States)

    Berger, Zoltán; Berger Salinas, Alexandra; Szánthó Pongrácz, György

    2015-08-01

    Albert Szent-Györgyi was a Hungarian biochemist and physiologist. He identified the structure and function of vitamin C, naming it as ascorbic acid. His research on cellular respiration and oxidation provided the basis for Krebs' citric acid cycle. He was awarded the Nobel Prize in 1937. With his collaborators, he discovered the biochemical basis of muscle contractility, isolating the basic proteins, giving them the name myosin and actin. Later on, he worked on the theory of carcinogenesis, linked to electron movements. He was one of the first researchers to describe the connection between free radicals and cancer. He lived a long, very complete life, defending always his opinion and freedom.

  18. GY-20和GY-40型大容量钴-60运输容器关键技术研究%Key Technology Studies of GY-20 and GY-40 High-Capacity Cobalt-60 Transport Casks

    Institute of Scientific and Technical Information of China (English)

    刘慧芳; 张鑫

    2012-01-01

    GY -20和GY- 40型大容量钴-60运输容器是为运输工业用钴-60成品源和钴-60棒束而设计的专用设备.由于内容物放射性活度水平高、衰变热大,仅有加拿大、英国、俄罗斯等少数国家具有设计能力.本文综合考虑容器结构、热工、力学、屏蔽等方面的要求,对容器设计和制造过程中的关键技术以及解决方案进行了分析研究.试验验证结果表明,容器的结构设计、包铅边界设计准则的确定和制造过程的质量控制措施合理、有效,能保证容器在各种工况下的屏蔽完整性,容器具有安全运输大容量钴-60源项的能力,其设计满足相关标准和规范要求,可为其他B型货包的设计提供参考.%GY-20 and GY-40 high-capacity cobalt-60 transport,casks are used to transport cobalt-60 industrial irradiators and cobalt-60 bundles. The radioactive contents have special features of high-activity and high residual heat, so only a few countries such as Canada, England and Russia have design capacity. The key technologies and corresponding solutions were studied for the design and manufacture of the cask taking into account the structural, thermal, mechanics and shield requests. A series of tests prove that the cask structure design, design criteria for lead coating structure and quality control measurements are reasonable and effective, and the cask shield integrity can be ensured for all conditions. The casks have ability to transport high-activity sealed sources safely, and the design of cask satisfies the requirement of design code and standard. It can provide reference for other B type package.

  19. 30 Gy or 34 Gy? Comparing 2 Single-Fraction SBRT Dose Schedules for Stage I Medically Inoperable Non-Small Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Videtic, Gregory M.M., E-mail: videtig@ccf.org; Stephans, Kevin L.; Woody, Neil M.; Reddy, Chandana A.; Zhuang, Tingliang; Magnelli, Anthony; Djemil, Toufik

    2014-09-01

    Purpose: To review outcomes of 2 single-fraction lung stereotactic body radiation therapy (SBRT) schedules used for medically inoperable early stage lung cancer. Methods and Materials: Patients in our institution have been treated on and off protocols using single-fraction SBRT (30 Gy and 34 Gy, respectively). All patients had node-negative lung cancer measuring ≤5 cm and lying ≥2 cm beyond the trachea-bronchial tree and were treated on a Novalis/BrainLAB system with the ExactTrac positioning system for daily image guidance. Results: For the interval from 2009 to 2012, 80 patients with 82 lesions were treated with single-fraction lung SBRT. Fifty-five patients (69%) and 25 patients (31%) received 30 Gy and 34 Gy, respectively. In a comparison of 30 Gy and 34 Gy cohorts, patient and tumor characteristics were balanced and median follow-up in months was 18.7 and 17.8, respectively. The average heterogeneity-corrected mean doses to the target were 33.75 Gy and 37.94 Gy for the 30-Gy and 34-Gy prescriptions, respectively. Comparing 30-Gy and 34-Gy cohorts, 92.7% and 84.0% of patients, respectively, experienced no toxicity (P was not significant), and had neither grade 3 nor higher toxicities. For the 30-Gy and 34-Gy patients, rates of 1-year local failure, overall survival, and lung cancer-specific mortality were 2.0% versus 13.8%, 75.0% versus 64.0%, and 2. 1% versus 16.0%, respectively (P values for differences were not significant). Conclusions: This is the largest single-fraction lung SBRT series yet reported. and it confirms the safety, efficacy, and minimal toxicity of this schedule for inoperable early stage lung cancer.

  20. Word, Body, Power: A Reading of Shakespeare’s Julius Caesar and Ariel Dorfman’s Death and the Maiden

    Directory of Open Access Journals (Sweden)

    Diego Saglia

    2014-05-01

    Full Text Available Il saggio prende in esame il corpo come luogo di operazioni di scrittura tese a mettere in scena effetti di potere “in atto”. Attraverso esplorazioni testuali di opere significative, sebbene lontane nel tempo e appartenenti a sistemi linguistico-culturali distanti, come il Julius Caesar di Shakespeare e La muerte y la doncella (Death and the Maiden di Ariel Dorfman, si intendono segnalare aspetti formali, modalità semiotiche, configurazioni ideologiche e strutture affettive proprie di una prassi retorica in cui la rappresentazione del corpo, tramite il linguaggio inteso come proiezione della fisicità, corrisponde a un’ostensione del potere come nesso di gesto e voce, azione e discorso – e soprattutto come zona di conflitto. Nelle due opere in questione la parola diventa visibile come meccanismo di esplicitazione di una fisicità che è zona di scontro e confronto tra effetti di potere quali la coercizione e la resistenza, tra occultamento e svelamento della verità, tra identità maschile e femminile. Alla luce di queste prove testuali, la scrittura del corpo si profila come una performance, densa di “intensità affettive”, dello stesso corpo in quanto punto di incrocio di effetti di parola e nucleo di atti ideologici e politici – un corpo, insomma, che è sia soggetto della storia, sia oggetto di molteplici operazioni e negoziazioni retoriche.

  1. Dose escalation in prostate radiotherapy up to 82 Gy using simultaneous integrated boost. Direct comparison of acute and late toxicity with 3D-CRT 74 Gy and IMRT 78 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Dolezel, Martin; Odrazka, Karel; Vanasek, Jaroslav [Oncology Center, Multiscan and Pardubice Regional Hospital, Pardubice (Czech Republic); Vaculikova, Miloslava [Dept. of Oncology, Hospital Nachod (Czech Republic); Sefrova, Jana; Paluska, Petr; Zouhar, Milan; Jansa, Jan; Macingova, Zuzana; Jarosova, Lida [Dept. of Oncology and Radiotherapy, Univ. Hospital Hradec Kralove (Czech Republic); Brodak, Milos; Moravek, Petr [Dept. of Urology, Univ. Hospital Hradec Kralove (Czech Republic); Hartmann, Igor [Dept. of Urology, Univ. Hospital Olomouc (Czech Republic)

    2010-04-15

    Purpose: To compare acute and late toxicity after three-dimensional conformal radiotherapy to the prostate to 74 Gy (3D-CRT) with intensity-modulated radiotherapy to 78 Gy (IMRT 78) and IMRT using simultaneous integrated boost to 82 Gy (IMRT/SIB 82). Patients and methods: 94 patients treated with 3D-CRT to the prostate and base of seminal vesicles to 74 Gy represented the first group. The second group consisted of 138 patients subjected to IMRT covering the prostate and base of seminal vesicles to 78 Gy. The last group was treated with IMRT using SIB. The prescribed doses were 82 Gy and 73.8 Gy in 42 fractions to the prostate and seminal vesicles. Late toxicity was prospectively scored according to the RTOG/FC-LENT scale. Results: Acute gastrointestinal toxicity {>=} grade 2 occurred in 35.1% of patients treated with 3D-CRT, in 16% subjected to IMRT 78, and in 7.7% receiving IMRT/SIB 82. Acute genitourinary toxicity {>=} grade 2 was observed in 26.6% (3D-CRT), 33% (IMRT 78), and 30.7% (IMRT/SIB 82). At 3 years, the estimated cumulative incidence of grade 3 late gastrointestinal toxicity was 14% for 3D-CRT, 5% for IMRT 78, and 2% for IMRT/SIB 82. The difference became significant (log rank p = 0.02). The estimated cumulative incidence of grade 3 late genitourinary toxicity was 9% (3D-CRT), 7% (IMRT 78), and 6% (IMRT/SIB 82) without statistical differences (log rank p = 0.32). Conclusion: SIB enables dose escalation up to 82 Gy with a lower rate of gastrointestinal toxicity grade 3 in comparison with 3D-CRT up to 74 Gy. (orig.)

  2. Challenges to the implementation of International Health Regulations (2005) on Preventing Infectious Diseases: experience from Julius Nyerere International Airport, Tanzania

    Science.gov (United States)

    Bakari, Edith; Frumence, Gasto

    2013-01-01

    Background The International Health Regulations (IHR) (2005) is a legal instrument binding all World Health Organization (WHO) member States. It aims to prevent and control public health emergencies of international concern. Country points of entry (POEs) have been identified as potential areas for effective interventions to prevent the transmission of infectious diseases across borders. The agreement postulates that member states will strengthen core capacities detailed in the IHR (2005), including those specified for the POE. This study intended to assess the challenges faced in implementing the IHR (2005) requirements at Julius Nyerere International Airport (JNIA), Dar es Salaam. Design A cross-sectional, descriptive study, employing qualitative methods, was conducted at the Ministry of Health and Social Welfare (MoHSW), WHO, and JNIA. In-depth interviews, focus group discussions (FGDs) and documentary reviews were used to obtain relevant information. Respondents were purposively enrolled into the study. Thematic analysis was used to generate study findings. Results Several challenges that hamper implementation of the IHR (2005) were identified: (1) none of the 42 Tanzanian POEs have been specifically designated to implement IHR (2005). (2) Implementation of the IHR (2005) at the POE was complicated as it falls under various uncoordinated government departments. Although there were clear communication channels at JNIA that enhanced reliable risk communication, the airport lacked isolated rooms specific for emergence preparedness and response to public health events. Conclusions JNIA is yet to develop adequate core capacities required for implementation of the IHR (2005). There is a need for policy managers to designate JNIA to implement IHR (2005) and ensure that public health policies, legislations, guidelines, and practice at POE are harmonized to improve international travel and trade. Policy makers and implementers should also ensure that implementation of

  3. La fotografía de Julius Shulman y la construcción de la imagen de la arquitectura del sur de California

    OpenAIRE

    Daniel Díez Martínez

    2014-01-01

    A Julius Shulman le correspondió, casi en exclusiva, la labor de cronista gráfico de la arquitectura moderna en el sur de California. Consciente de la dificultad de hacer ver al público la belleza de estas construcciones, Shulman desarrolló un lenguaje propio con un marcado sentido escenográfico, un encuentro entre la fotografía arquitectónica clásica y la publicidad contemporánea inspirada en la cultura pop en la que la colocación de los muebles en intervalos estratégicos, la iluminación, la...

  4. Hypofractionated helical tomotherapy (75 Gy at 2.5 Gy per fraction for localized prostate cancer: long-term analysis of gastrointestinal and genitourinary toxicity

    Directory of Open Access Journals (Sweden)

    Kong M

    2014-04-01

    Full Text Available Moonkyoo Kong,1 Seong Eon Hong,1 Sung-Goo Chang21Department of Radiation Oncology, 2Department of Urology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of KoreaBackground: This study is a report on the long-term analysis of acute and late toxicities for patients with localized prostate cancer treated with hypofractionated helical tomotherapy.Methods: From January 2008 through August 2013, 70 patients with localized prostate cancer were treated definitively with hypofractionated helical tomotherapy. The helical tomotherapy was designed to deliver 75 Gy in 2.5 Gy per fraction to the prostate gland, 63 Gy in 2.1 Gy per fraction to the seminal vesicles, and 54 Gy in 1.8 Gy per fraction to the pelvic lymph nodes. Incidence rates and predictive factors for radiation toxicities were analyzed retrospectively.Results: The incidences of grades 0, 1, and 2 acute gastrointestinal (GI toxicity were 51.4%, 42.9%, and 5.7%, and those of acute genitourinary (GU toxicity were 7.1%, 64.3%, and 28.6%, respectively. The maximum dose of rectum and bladder V40 and V50 were significant predictive factors for acute GI and GU toxicity. The cutoff value of rectum maximum dose and bladder V40 and V50 by receiver-operating characteristic curves analysis were 76.5 Gy, 17.3%, and 10.2%, respectively. The incidences of grades 0, 1, and 2 late GI toxicity were 82.0%, 14.0%, and 4.0%, and those of late GU toxicity were 18.0%, 56.0%, and 26.0%, respectively. Rectum V70 and bladder V70 and V75 were significant predictive factors for late GI and GU toxicity. The cutoff value of rectum V70 and bladder V70 and V75 by receiver-operating characteristic curves analysis was 2.8%, 2.8%, and 1.0%, respectively.Conclusion: Hypofractionated helical tomotherapy using a schedule of 75 Gy at 2.5 Gy per fraction had favorable acute and late toxicity rates and no serious complication, such as grade 3 or worse toxicity. To minimize radiation

  5. [Functional alterations in the retina following a 10 Gy gamma irradiation localized in the eye].

    Science.gov (United States)

    Bagot, J D; Courant, D; Court, L

    1980-11-17

    A single-eye irradiation of 10 Gy (0.8 Gy. min-1) induces impairments of the electrical responses of the rabbit retina in dark adaptation. These are associated with reversible alteration of the photoreceptors and the preganglionic neurons and a disturbance of all the mechanisms of adaptation. Possible relationships between these functional alterations and the effects of irradiation are discussed.

  6. GY SAMPLING THEORY AND GEOSTATISTICS: ALTERNATE MODELS OF VARIABILITY IN CONTINUOUS MEDIA

    Science.gov (United States)

    In the sampling theory developed by Pierre Gy, sample variability is modeled as the sum of a set of seven discrete error components. The variogram used in geostatisties provides an alternate model in which several of Gy's error components are combined in a continuous mode...

  7. THE SAMPLING THEORY OF PIERRE GY COMPARISONS, IMPLEMENTATION, AND APPLICATIONS FOR ENVIRONMENTAL SAMPLING

    Science.gov (United States)

    The sampling theory developed and decribed by Pierre Gy is compared to design-based classical finite sampling methods for estimation of a ratio of random variables. For samples of materials that can be completely enumerated, the methods are asymptotically equivalent. Gy extends t...

  8. Model-based system engineering in support of the eGY data lifecycle objectives

    Science.gov (United States)

    Hartman, Leo; Melanson, Philip; Piggott, Stephen

    The objectives of the Electronic Geophysical Year (eGY) address the challenges and opportunities associated with modern digital technology for the creation and delivery of earth science data. In particular, eGY focuses on issues of access, sharing, archiving and interoperability of this science data and their associated enabling tools. System engineering supported by modelbased tools and techniques has a pivotal role to play in this endeavor since for most space missions the first formal representation of eGY related data results from system engineering activities and the extent to which these activities and the resulting representations (or models) make data life cycle issues prominent is the extent to which eGY objectives are satisfied or supported by the particular missions. The paper will review ongoing system engineering standardization efforts addressing the data life cycle and in particular will review how relatively new model-based system engineering methodologies contribute to eGY objectives.

  9. Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer.

    Science.gov (United States)

    Mirjolet, Céline; Walker, Paul M; Gauthier, Mélanie; Dalban, Cécile; Naudy, Suzanne; Mazoyer, Frédéric; Martin, Etienne; Maingon, Philippe; Créhange, Gilles

    2016-11-04

    To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC25-50). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC25-50 and the appearance of any acute GI toxicity. The rates of acute grade 1 (G1), G2 and G3 GI toxicities were 53.3 %, 10.6 % and 1.1 %, respectively. No G4+ toxicity was observed. Rectal V25 to V75 expressed in % were not predictive of G ≥ 1 GI toxicity (p ≥ 0.12) whereas rectal V25 to V50 expressed in cc did correlate with GI toxicity G ≥ 1 (p ≤ 0.04). rAUC25-50 expressed in cc. Gy correlated significantly with the occurrence of any acute GI toxicity G ≥ 1 (p = 0.027). The absolute volume of the rectum between 25Gy and 50Gy and rAUC25-50 could significantly predict any acute rectal toxicity in prostate cancer patients treated with daily IG-IMRT.

  10. The pre-Anschluss Vienna School of Medicine - the physicians: Sigmund Freud (1856-1939), Julius Wagner-Jauregg (1857-1940) and Karel Wenckebach (1864-1940).

    Science.gov (United States)

    Shaw, Lily Bzl; Shaw, Robert A

    2016-05-01

    Three physicians are discussed. Sigmund Freud, probably the best-known member of the Vienna School of Medicine, was the path-breaking pioneer in psychoanalysis and psychotherapy. Julius Wagner-Jauregg was a psychiatrist who discovered the link between iodine deficiency and goitre and also developed malaria therapy to treat progressive paralysis caused by syphilis for which he was awarded the Nobel Prize. Karel Wenckebach, the pioneering Dutch cardiologist, is best known for the Wenckebach block. After the Anschluss, fate dealt very different hands to these three physicians. Freud fled to London where he soon died. Wagner-Jauregg, who had some pan-Germanic sympathies as well as views on eugenics, left a controversial legacy. The Dutch cardiologist Wenckebach died in Vienna shortly after his homeland had been invaded in 1940 by that of his hosts. © IMechE 2014.

  11. Studies of the effect of 0. 4-Gy and 0. 6-Gy prenatal X-irradiation on postnatal adult behavior in the Wistar rat

    Energy Technology Data Exchange (ETDEWEB)

    Jensh, R.P.; Brent, R.L.; Vogel, W.H.

    1987-02-01

    Thirty-four pregnant Wistar rats were X-irradiated on the 9th or 17th day of gestation at a dosage level 0.4 Gy or 0.6 Gy or were sham-irradiated. All mothers were allowed to deliver their offspring, and litters were limited to a maximum of eight on day 2. On day 30, 224 offspring were weaned and raised until 60 days of age, at which time testing began. Each rat randomly received, in random order, three of the following six behavioral tests: Water T-maze, Conditioned Avoidance Response, Forelimb Hanging, Activity Wheel, Swimming, and Open Field. There were no statistically significant differences between the irradiated and control groups for maternal weight or weight gain or mean litter size, although the litter size of the 17th day 0.6-Gy group was slightly lower. Among offspring irradiated with 0.6 Gy on the 17th day, 3-day-old neonates' weights were significantly reduced. Offspring irradiated on the 17th day with 0.6 Gy exhibited higher Conditioned Avoidance Response 5th-day and retest avoidance scores than did the controls. There were also significant sex differences in responses within the irradiated and control groups for several tests, which were unrelated to radiation exposure. The results of this study indicate that low-level X-irradiation during the fetal period of rat gestation results in neonatal growth retardation and subtle behavioral alterations that may be manifested in adult life. Growth retardation may be the most sensitive indicator of subtle effects that result from low-level prenatal exposure to X-rays.

  12. GY SAMPLING THEORY IN ENVIRONMENTAL STUDIES 1: ASSESSING SOIL SPLITTING PROTOCOLS

    Science.gov (United States)

    Five soil sample splitting methods (riffle splitting, paper cone riffle splitting, fractional shoveling, coning and quartering, and grab sampling) were evaluated with synthetic samples to verify Pierre Gy sampling theory expectations. Individually prepared samples consisting of l...

  13. Radiation optic neuropathy and retinopathy with low dose (20 Gy radiation treatment

    Directory of Open Access Journals (Sweden)

    Crandall E. Peeler

    2016-10-01

    Conclusions and importance: Though cumulative radiation doses to the anterior visual pathway of less than 50 Gy are traditionally felt to be safe, it is important to consider not just the total exposure but also the size of individual fractions. The single-dose threshold for RON in proton beam treatment has yet to be defined. Our case suggests that fractions of less than 10 Gy should be delivered to minimize the risk of optic nerve injury.

  14. 20 Gy Versus 44 Gy of Supplemental External Beam Radiotherapy With Palladium-103 for Patients With Greater Risk Disease: Results of a Prospective Randomized Trial

    Energy Technology Data Exchange (ETDEWEB)

    Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org [Schiffler Cancer Center/Wheeling Jesuit University, Wheeling, WV (United States); Wallner, Kent E. [Puget Sound Healthcare Corporation, University of Washington, Seattle, WA (United States); Butler, Wayne M.; Galbreath, Robert W. [Schiffler Cancer Center/Wheeling Jesuit University, Wheeling, WV (United States); Taira, Al V. [Western Radiation Oncology Inc, Mountain View, CA (United States); Orio, Peter [Department of Radiation Oncology, Dana Farber Cancer Institute/Brigham and Women' s Hospital, Harvard Medical School, Boston, MA (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, WV (United States)

    2012-03-01

    Purpose: The necessity of external beam radiotherapy (EBRT) as a supplement to prostate brachytherapy remains unknown. We report brachytherapy outcomes for patients with higher risk features randomized to substantially different supplemental EBRT regimens. Methods and Materials: Between December 1999 and June 2004, 247 patients were randomized to 20 Gy vs. 44 Gy EBRT followed by a palladium-103 boost (115 Gy vs. 90 Gy). The eligibility criteria included clinically organ-confined disease with Gleason score 7-10 and/or pretreatment prostate-specific antigen (PSA) level 10-20 ng/mL. The median follow-up period was 9.0 years. Biochemical progression-free survival (bPFS) was defined as a PSA level of {<=}0.40 ng/mL after nadir. The median day 0 prescribed dose covering 90% of the target volume was 125.7%; 80 men received androgen deprivation therapy (median, 4 months). Multiple parameters were evaluated for their effect on bPFS. Results: For the entire cohort, the cause-specific survival, bPFS, and overall survival rates were 97.7%, 93.2%, and 80.8% at 8 years and 96.9%, 93.2%, and 75.4% at 10 years, respectively. The bPFS rate was 93.1% and 93.4% for the 20-Gy and 44-Gy arms, respectively (p = .994). However, no statistically significant differences were found in cause-specific survival or overall survival were identified. When stratified by PSA level of {<=}10 ng/mL vs. >10 ng/mL, Gleason score, or androgen deprivation therapy, no statistically significant differences in bPFS were discerned between the two EBRT regimens. On multivariate analysis, bPFS was most closely related to the preimplant PSA and clinical stage. For patients with biochemically controlled disease, the median PSA level was <0.02 ng/mL. Conclusion: The results of the present trial strongly suggest that two markedly different supplemental EBRT regimens result in equivalent cause-specific survival, bPFS, and overall survival. It is probable that the lack of benefit for a higher supplemental EBRT dose

  15. The Gypsy Database (GyDB) of mobile genetic elements: release 2.0.

    Science.gov (United States)

    Llorens, Carlos; Futami, Ricardo; Covelli, Laura; Domínguez-Escribá, Laura; Viu, Jose M; Tamarit, Daniel; Aguilar-Rodríguez, Jose; Vicente-Ripolles, Miguel; Fuster, Gonzalo; Bernet, Guillermo P; Maumus, Florian; Munoz-Pomer, Alfonso; Sempere, Jose M; Latorre, Amparo; Moya, Andres

    2011-01-01

    This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org.

  16. Heterotopic Ossification Prophylaxis After Total Hip Arthroplasty: Randomized Trial of 400 vs 700 cGy.

    Science.gov (United States)

    Liu, Jane Z; Frisch, Nicholas B; Barden, Regina M; Rosenberg, Aaron G; Silverton, Craig D; Galante, Jorge O

    2017-04-01

    Heterotopic ossification (HO) is a known complication following total hip arthroplasty. Radiation is an effective prophylaxis, but an optimal protocol has yet to be determined. We performed a randomized, double-blinded clinical trial in high-risk patients to determine the efficacy of 400 vs 700 cGy doses of radiation. One hundred forty-seven patients undergoing total hip arthroplasty and at high risk for HO at an urban medical center were randomized to receive either a single 400 or 700 cGy dose of radiation postoperatively. High risk was defined as a diagnosis of diffuse idiopathic skeletal hyperostosis, hypertrophic osteoarthritis, ankylosing spondylitis, or history of previous HO. Radiation was administered on the first or second postoperative day. A single blinded reviewer graded radiographs taken immediately postoperatively and at a minimum of 6 months postoperatively using the Brooker classification. Progression was defined as an increase in Brooker classification. Operative data including surgical approach, implant fixation, revision surgery, and postoperative range of motion data were also collected. A significantly greater portion of patients who received the 400 cGy dose demonstrated progression of HO than patients who received the 700 cGy dose. There were no wound complications. No preoperative factors were associated with a higher rate of progression. Patients who progressed had less flexion on physical examination than patients who did not progress, but this was not clinically significant. Seven hundred centigray was superior to 400 cGy in preventing HO formation following total hip arthroplasty in high-risk patients and may be the more effective treatment in this population. Further studies comparing 700 cGy to dosages between 400 and 700 cGy may help to clarify if a more optimal dose can be identified. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Hubungan antara Demografi Konsumen dengan Kepuasan terhadap Layanan Paket Perawatan Spa di GY Spa Jakartal

    Directory of Open Access Journals (Sweden)

    Hera Oktadiana

    2010-11-01

    Full Text Available Spa industry has been growing quite fast in many parts of the world, including Indonesia. The prospect of spa business is still very positive and wide open. There are many varieties of spas offered, such as day spas, hotel-based spas, resort spas and destination spas. Regardless of the type of spa, most spa operators provide massage and nutrition related services. GY Spa, one of the best spa operators in Jakarta offers several spa packages which include body massage, body treatment, body scrub, face massage and aromatheraphy. This research aims to find the correlation between the demographic segmentation and the consumer satisfaction towards the spa packages in GY Spa. Based on the research, it is found that education, occupation and nationality have no correlation toward the consumer satisfaction, while age and gender shown to have correlation. Female and the younger customers are more satisfied with the spa packages offered by GY Spa. 

  18. Raising the Albedo of 2010 GY6: Fitting ATPM to Wise Data

    Science.gov (United States)

    Wooden, D. H.; Rozitis, B. D.; Jefferson, J. D.; Nelson, T. W.; Dotson, J. L.

    2017-01-01

    Near-Earth Asteroid 462775 (2010 GY6) is in the Apollo orbit-family with a 1.46 year orbital period. 2010 GY6 was measured by WISE and fitted with NEATM, yielding NEATM model parameters of D=1.1 km, pv=0.028 and eta=2.3.The NEATM-derived geometric albedo of 2010 GY6 is lower than the surface of comet 67P/C-G. The eta value is considerably higher than typical for its phase angle of 33 deg, indicating a cooler surface due to non-zero thermal inertia and/or surface roughness are important. If the thermal inertia and surface roughness are constrained by fitting the Advanced Thermophysical Model (ATPM) to the WISE data, what would the resulting geometric albedo? We find pv=0.06-0.08, in the same range as B- or C-type NEAs like Bennu or JU3.

  19. Hypofractionated Radiation Therapy (66 Gy in 22 Fractions at 3 Gy per Fraction) for Favorable-Risk Prostate Cancer: Long-term Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Nita [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Faria, Sergio, E-mail: sergio.faria@muhc.mcgill.ca [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Cury, Fabio; David, Marc; Duclos, Marie; Shenouda, George; Ruo, Russell; Souhami, Luis [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada)

    2013-07-01

    Purpose: To report long-term outcomes of low- and intermediate-risk prostate cancer patients treated with high-dose hypofractionated radiation therapy (HypoRT). Methods and Materials: Patients with low- and intermediate-risk prostate cancer were treated using 3-dimensional conformal radiation therapy to a dose of 66 Gy in 22 daily fractions of 3 Gy without hormonal therapy. A uniform 7-mm margin was created around the prostate for the planning target volume, and treatment was prescribed to the isocenter. Treatment was delivered using daily ultrasound image-guided radiation therapy. Common Terminology Criteria for Adverse Events, version 3.0, was used to prospectively score toxicity. Biochemical failure was defined as the nadir prostate-specific antigen level plus 2 ng/mL. Results: A total of 129 patients were treated between November 2002 and December 2005. With a median follow-up of 90 months, the 5- and 8-year actuarial biochemical control rates were 97% and 92%, respectively. The 5- and 8-year actuarial overall survival rates were 92% and 88%, respectively. Only 1 patient died from prostate cancer at 92 months after treatment, giving an 8-year actuarial cancer-specific survival of 98%. Radiation therapy was well tolerated, with 57% of patients not experiencing any acute gastrointestinal (GI) or genitourinary (GU) toxicity. For late toxicity, the worst grade ≥2 rate for GI and GU toxicity was 27% and 33%, respectively. There was no grade >3 toxicity. At last follow-up, the rate of grade ≥2 for both GI and GU toxicity was only 1.5%. Conclusions: Hypofractionation with 66 Gy in 22 fractions prescribed to the isocenter using 3-dimensional conformal radiation therapy produces excellent biochemical control rates, with moderate toxicity. However, this regimen cannot be extrapolated to the intensity modulated radiation therapy technique.

  20. Fludarabine and 2-Gy TBI is superior to 2 Gy TBI as conditioning for HLA-matched related hematopoietic cell transplantation: a phase III randomized trial.

    Science.gov (United States)

    Kornblit, Brian; Maloney, David G; Storb, Rainer; Storek, Jan; Hari, Parameswaran; Vucinic, Vladan; Maziarz, Richard T; Chauncey, Thomas R; Pulsipher, Michael A; Bruno, Benedetto; Petersen, Finn B; Bethge, Wolfgang A; Hübel, Kai; Bouvier, Michelle E; Fukuda, Takahiro; Storer, Barry E; Sandmaier, Brenda M

    2013-09-01

    The risks and benefits of adding fludarabine to a 2-Gy total body irradiation (TBI) nonmyeloablative regimen are unknown. For this reason, we conducted a prospective randomized trial comparing 2-Gy TBI alone, or in combination with 90 mg/m(2) fludarabine (FLU/TBI), before transplantation of peripheral blood stem cells from HLA-matched related donors. Eighty-five patients with hematological malignancies were randomized to be conditioned with TBI alone (n = 44) or FLU/TBI (n = 41). All patients had initial engraftment. Two graft rejections were observed, both in the TBI group. Infection rates, nonrelapse mortality, and graft-versus-host disease (GVHD) were similar between groups. Three-year overall survival was lower in the TBI group (54% versus 65%; hazard ratio [HR], .57; P = .09), with higher incidences of relapse/progression (55% versus 40%; HR, .55; P = .06), relapse-related mortality (37% versus 28%; HR, .53; P = .09), and a lower progression-free survival (36% versus 53%; HR, .56; P = .05). Median donor T cell chimerism levels were significantly lower in the TBI group at days 28 (61% versus 90%; P < .0001) and 84 (68% versus 92%; P < .0001), as was NK cell chimerism on day 28 (75% versus 96%; P = .0005). In conclusion, this randomized trial demonstrates the importance of fludarabine in augmenting the graft-versus-tumor effect by ensuring prompt and durable high-level donor engraftment early after transplantation.

  1. 基于Julius的机器人语音识别系统构建%Robot Speech Recognition System Based on Julius

    Institute of Scientific and Technical Information of China (English)

    付维; 刘冬; 闵华松

    2011-01-01

    As a result of the continuous development of robot technology, speech recognition of the robot is proposed as intelligent hu- man-computer interaction. After studying the basic principles of HMM speech recognition, in the robot platform of laboratory speech recognition system for isolated words is achieved with open source HTK and Julius. Using the speech recognition system, we can extract the voice command for robot control.%随着机器人技术不断发展,本文提出机器人的语音识别这一智能人机交互方式。在研究了基于HMM语音识别基本原理的情况下,在实验室的机器人平台上,利用HTK和Julius开源平台,构建了一个孤立词的语音识别系统。利用该语音识别系统可以提取语音命令用于机器人的控制。

  2. Rationale for a generic phytosanitary irradiation dose of 70 Gy for the genus Anastrepha (Diptera: Tephritidae)

    Science.gov (United States)

    The phytosanitary irradiation (PI) literature of the genus Anastrepha was analyzed to determine if it was sufficient to support a generic dose <150 Gy (the accepted generic dose for all of Tephritidae) that could be used on fruit in areas of the tropical and subtropical Americas where only species o...

  3. Cancer risk above 1 Gy and the impact for space radiation protection

    Science.gov (United States)

    Schneider, Uwe; Walsh, Linda

    2009-07-01

    Analyses of the epidemiological data on the Japanese A-bomb survivors, who were exposed to γ-rays and neutrons, provide most current information on the dose-response of radiation-induced cancer. Since the dose span of main interest is usually between 0 and 1 Gy, for radiation protection purposes, the analysis of the A-bomb survivors is often focused on this range. However, estimates of cancer risk for doses larger than 1 Gy are becoming more important for long-term manned space missions. Therefore in this work, emphasis is placed on doses larger than 1 Gy with respect to radiation-induced solid cancer and leukemia mortality. The present analysis of the A-bomb survivors data was extended by including two extra high-dose categories and applying organ-averaged dose instead of the colon-weighted dose. In addition, since there are some recent indications for a high neutron dose contribution, the data were fitted separately for three different values for the relative biological effectiveness (RBE) of the neutrons (10, 35 and 100) and a variable RBE as a function of dose. The data were fitted using a linear and a linear-exponential dose-response relationship using a dose and dose-rate effectiveness factor (DDREF) of both one and two. The work presented here implies that the use of organ-averaged dose, a dose-dependent neutron RBE and the bending-over of the dose-response relationship for radiation-induced cancer could result in a reduction of radiation risk by around 50% above 1 Gy. This could impact radiation risk estimates for space crews on long-term mission above 500 days who might be exposed to doses above 1 Gy. The consequence of using a DDREF of one instead of two increases cancer risk by about 40% and would therefore balance the risk decrease described above.

  4. Validation and substantiation of 25 kGy as sterilization dose for lyophilized human amnion membrane.

    Science.gov (United States)

    Djefal, A; Tahtat, D; Khodja, A Nacer; Bouzid, S Saad; Remane, N

    2007-01-01

    The validation and substantiation of sterilization dose for lyophilized human amnion membrane by gamma irradiation delivered by Co60 source were investigated. The validation experiments were conducted according to ISO 13409 method B. A total of 120 human amnion membranes were collected. Of these, 10 membranes were used for estimation of bioburden and 20 membranes were used for the individual sterility test at verification dose. The average bioburden per product unit with sample item portion (SIP = 1) for lyophilized human amnion membrane was 572 cfu. The verification dose experiments were done at dose of 8.1 kGy and the results of sterility tests showed that human amnion membrane got one positive. Consequently, the sterilization dose of 25 kGy was confirmed and substantiated.

  5. What Powers the 3000-Day Light Curve of SN 2006gy?

    CERN Document Server

    Fox, Ori D; Ammons, S Mark; Andrews, Jennifer; Bostroem, K Azalee; Cenko, S Bradley; Clayton, Geoffrey C; Dwek, Eli; Filippenko, Alexei V; Gallagher, Joseph S; Kelly, Patrick L; Mauerhan, Jon C; Miller, Adam M; Van Dyk, Schuyler D

    2015-01-01

    SN 2006gy was the most luminous SN ever observed at the time of its discovery and the first of the newly defined class of superluminous supernovae (SLSNe). The extraordinary energetics of SN 2006gy and all SLSNe (>10^51 erg) require either atypically large explosion energies (e.g., pair-instability explosion) or the efficient conversion of kinetic into radiative energy (e.g., shock interaction). The mass-loss characteristics can therefore offer important clues regarding the progenitor system. For the case of SN 2006gy, both a scattered and thermal light echo from circumstellar material (CSM) have been reported at later epochs (day ~800), ruling out the likelihood of a pair-instability event and leading to constraints on the characteristics of the CSM. Owing to the proximity of the SN to the bright host-galaxy nucleus, continued monitoring of the light echo has not been trivial, requiring the high resolution offered by the Hubble Space Telescope (HST) or ground-based adaptive optics (AO). Here we report detect...

  6. ULTRACAM photometry of the eclipsing cataclysmic variables GY Cnc, IR Com and HT Cas

    CERN Document Server

    Feline, W J; Marsh, T R; Watson, C A; Littlefair, S P

    2005-01-01

    We present high-speed, three-colour photometry of the eclipsing cataclysmic variables GY Cnc, IR Com and HT Cas. We find that the sharp eclipses in GY Cnc and IR Com are due to eclipses of the white dwarf. There is some evidence for a bright spot on the edge of the accretion disc in GY Cnc, but not in IR Com. Eclipse mapping of HT Cas is presented which shows changes in the structure of the quiescent accretion disc. Observations in 2002 show the accretion disc to be invisible except for the presence of a bright spot at the disc edge. 2003 observations, however, clearly show a bright inner disc and the bright spot to be much fainter than in 2002. Although no outburst was associated with either set of quiescent observations, the system was ~0.6 mJy brighter in 2003, mainly due to the enhanced emission from the inner disc. We propose that these changes are due to variations in the mass transfer rate from the secondary star and through the disc. The disc colours indicate that it is optically thin in both its inne...

  7. Study on the Flocculability of Metal Ions by Bacillus Mucilaginosus GY03 Strain

    Institute of Scientific and Technical Information of China (English)

    连宾; 陈烨; 袁生; 朱立军; 刘丛强

    2004-01-01

    This study deals with the flocculability of two types of metal ions by Bacillus mucilaginosus GY03 Strain, with an emphasis on the influence of pH conditions, volume and time of flocculants produced by GY03 Strain on the adsorption of metal irons such as Pb+2 and Mn+2 and the capabilities of flocculants to adsorb metal ions of different concentrations. The results showed that microbial flocculants produced by Bacillus mucilaginosus GY03 Strain are highly capable of flocculating metal ions, but show different effectiveness with respect to the adsorption of Pb+2 and Mn+2. In accordance with the experimental data and actual waste-water treatment conditions, the relevant regression equation of flocculation has been deduced, which has found some application in practice. The experimental results of this study demonstrated that microbial flocculants produced by Bacillus mucilaginosus can be used to treat metallic ion-containing waste water. In practical application the volume of microbial flocculants required and flocculation conditions should be taken into comprehensive consideration in accordance with the properties of metal ions, the composition of anions and the solubility of other metals, in combination with the cost and effectiveness of flocculants to be used. Flocculant used in this experiment has the advantages of being applied over a wide range of pH values, small flocculant volume, and rapid speed of flocculation. So this kind of flocculant is within excellent prospect of application.

  8. The case for a generic phytosanitary irradiation dose of 250 Gy for Lepidoptera eggs and larvae

    Science.gov (United States)

    Hallman, Guy J.; Arthur, Valter; Blackburn, Carl M.; Parker, Andrew G.

    2013-08-01

    The literature on ionizing irradiation of Lepidoptera is critically examined for a dose that could serve as a generic phytosanitary treatment for all eggs and larvae of that order, which contains many quarantine pests that inhibit trade in fresh agricultural commodities. The measure of efficacy used in deriving this dose is the prevention of emergence of normal-looking adults that are assumed not able to fly. A dose of 250 Gy is supported by many studies comprising 34 species in 11 lepidopteran families, including those of significant quarantine importance. Two studies with two different species found that doses >250 Gy were necessary, but both of these are contradicted by other studies showing that 10,000 individuals) testing for families other than Tortricidae (the most important quarantine family in the Lepidoptera). Because several large-scale studies have been done with tortricids a dose of 250 Gy could be justifiable for Tortricidae if it is not acceptable for the entire Lepidoptera at this time.

  9. Muusikamaailm : "Represseeritud muusika" Moskvas. György Kurtagi festival Londonis. Junge Deutshe Philarmonie kevad. Herbert Wernicke lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Moskvas toimuvast festivalist "Represseeritud muusika". Londonis toimuvast György Kurtagi festivalist. Saksa orkestri Junge Deutshe Philarmonie kevadesinemistest. Suri saksa ooperilavastaja Herbert Wernicke

  10. Muusikamaailm : "Represseeritud muusika" Moskvas. György Kurtagi festival Londonis. Junge Deutshe Philarmonie kevad. Herbert Wernicke lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Moskvas toimuvast festivalist "Represseeritud muusika". Londonis toimuvast György Kurtagi festivalist. Saksa orkestri Junge Deutshe Philarmonie kevadesinemistest. Suri saksa ooperilavastaja Herbert Wernicke

  11. La fotografía de Julius Shulman y la construcción de la imagen de la arquitectura del sur de California

    Directory of Open Access Journals (Sweden)

    Daniel Díez Martínez

    2014-10-01

    Full Text Available A Julius Shulman le correspondió, casi en exclusiva, la labor de cronista gráfico de la arquitectura moderna en el sur de California. Consciente de la dificultad de hacer ver al público la belleza de estas construcciones, Shulman desarrolló un lenguaje propio con un marcado sentido escenográfico, un encuentro entre la fotografía arquitectónica clásica y la publicidad contemporánea inspirada en la cultura pop en la que la colocación de los muebles en intervalos estratégicos, la iluminación, la elección y actitud de los modelos o la vegetación estaban cuidadosamente estudiados para guiar la vista del espectador hacia la arquitectura y el estilo de vida que de esta se desprendía. El artículo propone una visión transversal de la fotografía de Shulman y establece lazos entre su obra y la tensión política que se respiraba en los Estados Unidos de la Guerra Fría. Gracias a las “escenas” capturadas en sus fotografías, la arquitec­tura moderna californiana quedaría por siempre asociada al contexto creado por el fotógrafo, dando lugar a imágenes que el tiempo ha elevado a la categoría de iconos culturales del siglo XX. Como la arquitectura que retrataba, la fotografía se convirtió en una exaltación de la modernidad entendida como una nueva era de bienestar, prosperidad y progreso.

  12. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    Science.gov (United States)

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  13. Comparing morbidity and cancer control after 3D-conformal (70/74 Gy) and intensity modulated radiotherapy (78/82 Gy) for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Dolezel, Martin [Multiscan Alpha Pardubice Regional Hospital, Oncology Centre, Pardubice (Czech Republic); Charles University in Prague, First Faculty of Medicine, Prague (Czech Republic); Faculty of Medicine and Dentistry, Department of Oncology, Olomouc (Czech Republic); Odrazka, Karel [Multiscan Alpha Pardubice Regional Hospital, Oncology Centre, Pardubice (Czech Republic); Charles University in Prague, First Faculty of Medicine, Prague (Czech Republic); Charles University in Prague, Third Faculty of Medicine, Prague (Czech Republic); Zouhar, Milan; Jansa, Jan; Paluska, Petr [University Hospital Hradec Kralove, Department of Oncology and Radiotherapy, Hradec Kralove (Czech Republic); Vaculikova, Miloslava [Hospital Trutnov, Department of Oncology, Trutnov (Czech Republic); Sefrova, Jana [Hospital Prachatice, Department of Oncology, Prachatice (Czech Republic); Kohlova, Tereza [Proton Therapy Center, Prague (Czech Republic); Vanasek, Jaroslav [Multiscan Alpha Pardubice Regional Hospital, Oncology Centre, Pardubice (Czech Republic); Kovarik, Josef [The Freeman Hospital, Northern Centre for Cancer Care, Newcastle upon Tyne (United Kingdom)

    2015-04-01

    The purpose of this work was to compare toxicity and cancer control between patients with prostate cancer treated using three-dimensional conformal radiotherapy (3D-CRT) and those treated using intensity-modulated radiation therapy (IMRT). A total of 553 patients with prostate cancer were treated with 3D-CRT 70-74 Gy (3D-CRT 70, 3D-CRT 74) or IMRT 78-82 Gy (IMRT 78, IMRT/SIB 82). Late toxicity was scored according to FC-RTOG/LENT criteria. Biochemical failure was defined using the Phoenix and ASTRO definitions. The 5-year risk of grade 2-4 genitourinary toxicity was 26.3 % (3D-CRT 70), 27.2 % (3D-CRT 74), 17.3 % (IMRT 78), and 25.1 % (IMRT/SIB 82) without statistical differences. The 5-year risk of grade 2-4 gastrointestinal toxicity was 19.4 % (3D-CRT 70), 42.1 % (3D-CRT 74), 20.5 % (IMRT 78), and 26.6 % (IMRT/SIB 82). The differences between 3D-CRT 74 and 3D-CRT 70 and between 3D-CRT 74 and IMRT 78 were statistically significant (log rank p = 0.03). The 5-year Phoenix PSA relapse-free survival (PSA-RFS) in low-risk, intermediate-risk, and high-risk patients treated using 3D-CRT were 89.4, 65.5, and 57.8 %, respectively. Patients treated with IMRT achieved the following results: 90.9, 89.4, and 83.9 %. Clinical relapse-free survival (C-RFS) in patients treated using 3D-CRT vs. IMRT for the aforementioned groups were 94.7 vs. 100 %, 86.8 vs. 98.6 %, and 84.4 vs. 94.5 %. Disease-free survival (DFS) for patients treated using 3D-CRT were 83.1, 70.9, and 71.5 %. The IMRT group reached 95.8, 89.1, and 87.6 %. The PSA-RFS for intermediate- and high-risk patients were statistically significant, while C-RFS and DFS were marginally better. Dose escalation with IMRT was associated with improved cancer control in intermediate- and high-risk patients in comparison with 3D-CRT, without compromising toxicity. (orig.) [German] Es erfolgte ein Vergleich von Toxizitaet und Tumorkontrolle bei Patienten mit Prostatakarzinom nach der Behandlung mit dreidimensionaler konformaler

  14. Is it effective to raise the irradiation dose from 80 to 85 Gy in gamma knife radiosurgery for trigeminal neuralgia?

    Science.gov (United States)

    Kim, Yong Hwy; Kim, Dong Gyu; Kim, Jin Wook; Kim, Young-Hoon; Han, Jung Ho; Chung, Hyun-Tai; Paek, Sun Ha

    2010-01-01

    In order to assess the effect of raising gamma knife radiosurgery (GKS) doses from 80 to 85 Gy for the treatment of trigeminal neuralgia (TN), the authors analyzed the outcomes of GKS in each group. The authors retrospectively collected follow-up data of 104 GKS procedures conducted for TN. Doses of 80 and 85 Gy were prescribed for 60 and 44 patients, respectively. The target was 2-4 mm anterior to the junction of the trigeminal nerve and pons. Outcomes were quantified based on facial pain levels and classified using the Barrow Neurological Institute scale. Actuarial rates of a favorable pain control outcome at 1 and 3 years after GKS were 75.0 and 61.2% for 80 Gy and 65.9 and 60.3% for 85 Gy. Post-GKS facial sensory loss developed in 20.6%. There was no statistically significant difference in pain control rate between the two groups. Time to maximal pain relief was shorter in the 85-Gy group. Protracted morbidity before GKS was a favorable prognostic factor of pain control in a multivariate analysis. According to our finding that 85 Gy brought more rapid clinical improvement without causing more complications, 85 Gy seems to be preferable to 80 Gy, but prospective randomized trials are mandatory to get a more definite conclusion on the optimal dose for GKS of TN.

  15. GyPSuM: A Detailed Tomographic Model of Mantle Density and Seismic Wave Speeds

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, N A; Forte, A M; Boschi, L; Grand, S P

    2010-03-30

    GyPSuM is a tomographic model fo mantle seismic shear wave (S) speeds, compressional wave (P) speeds and detailed density anomalies that drive mantle flow. the model is developed through simultaneous inversion of seismic body wave travel times (P and S) and geodynamic observations while considering realistic mineral physics parameters linking the relative behavior of mantle properties (wave speeds and density). Geodynamic observations include the (up to degree 16) global free-air gravity field, divergence of the tectonic plates, dynamic topography of the free surface, and the flow-induced excess ellipticity of the core-mantle boundary. GyPSuM is built with the philosophy that heterogeneity that most closely resembles thermal variations is the simplest possible solution. Models of the density field from Earth's free oscillations have provided great insight into the density configuration of the mantle; but are limited to very long-wavelength solutions. Alternatively, simply scaling higher resolution seismic images to density anomalies generates density fields that do not satisfy geodynamic observations. The current study provides detailed density structures in the mantle while directly satisfying geodynamic observations through a joint seismic-geodynamic inversion process. Notable density field observations include high-density piles at the base of the superplume structures, supporting the fundamental results of past normal mode studies. However, these features are more localized and lower amplitude than past studies would suggest. When we consider all seismic anomalies in GyPSuM, we find that P and S-wave speeds are strongly correlated throughout the mantle. However, correlations between the high-velocity S zones in the deep mantle ({approx} 2000 km depth) and corresponding P-wave anomalies are very low suggesting a systematic divergence from simplified thermal effects in ancient subducted slab anomalies. Nevertheless, they argue that temperature variations are

  16. Effects of 2. 0 Gy of /sup 60/Co gamma rays irradiation on rat embryos

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Juing-Yi; Satow, Yukio

    1987-01-01

    Pregnant rats of Donryu strain were exposed to a whole-body /sup 60/Co ..gamma.. ray irradiation of a single dose of 2.0 Gy (Dose rate: 0.5 Gy/min) on day 7, 8, 9, 10 or 11 of gestation (sperm day = day 0). The rats were sacrificed on day 18 and the offspring were examined for external and visceral malformations. Malformed embryos occurred between days 7 and 11 with the highest incidence occurring on day 9. Dose with 2.0 Gy increased the rate of resorption or death (52.1 %), in the survivors, caused congenital malformation in a majority of embryos (86.5 %) on day 8 of gestation. There is an increase in malformation (93.3 %) and growth retardation, but no increase in mortality (42.9 %) on day 9 of gestation. Relatively few anomalies resulted from irradiation on day 7 of gestation. The peak day for cardiovascular anomalies occurred on day 9 (88.3 % of all survival embryos) with high levels also occurring on day 8 (86.5 %). Cardiovascular anomalies consisted of VSD, hypoplasia of the pulmonary trunk, coarctation of the aorta, double aortic arch, right aortic arch, riding aorta, complete transposition of the aorta, persistent atrioventricular canal, vascular ring, aberrant right subclavian artery and others. Similar anomalies, but at a lower incidence, were produced by /sup 60/Co ..gamma.. ray at dose levels of 2.0 Gy on day 10 or 11 of gestation. Cases of cleft lip and cleft palate or facial cleft were observed seventeen fetuses on day 9 of gestation (31 %). Exencephaly occurred in nine embryos treated on day 9 (16.1 %) and in one embryos treated on day 10. Tail defects appeared with treatment on day 9 with the latter predominating on day 11. The present study show that maximum resorption (52.1 %) was seen with treatment on day 8 whereas the highest rate of malformation (93.3 %) was observed with treatment on day 9. (J.P.N.).

  17. Local Sensorium, Local Cinema: György Pálfi’s Sensuous Body Politics

    Directory of Open Access Journals (Sweden)

    Kalmár György

    2014-09-01

    Full Text Available György Pálfi’s Hukkle (2002 and Taxidermia (2006 establish markedly unique cinematic styles and richly sensorial life-worlds, which function in both films as counter-discourses opposing official history, hegemonic ideologies, and conventional patterns of (cinematic understanding. In the present study I analyse the ways Pálfi’s films communicate through non-symbolic meaning, bodily discourses, and a heavy reliance on the multisensory evocation of the local sensorium (Marks and the local habitus (Bourdieu so as to create significance on the margins of established, hegemonic systems of meaning, cinema, ideology and identity.

  18. Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs.

    Science.gov (United States)

    Lenarczyk, Marek; Lam, Vy; Jensen, Eric; Fish, Brian L; Su, Jidong; Koprowski, Stacy; Komorowski, Richard A; Harmann, Leanne; Migrino, Raymond Q; Li, X Allen; Hopewell, John W; Moulder, John E; Baker, John E

    2013-09-01

    The objective of this study was to determine whether radiation-induced injury to the heart after 10 Gy total body irradiation (TBI) is direct or indirect. Young male WAG/RijCmcr rats received a 10 Gy single dose using TBI, upper hemi-body (UHB) irradiation, lower hemi-body (LHB) irradiation, TBI with the kidneys shielded or LHB irradiation with the intestines shielded. Age-matched, sham-irradiated rats served as controls. The lipid profile, kidney injury, heart and liver morphology and cardiac function were determined up to 120 days after irradiation. LHB, but not UHB irradiation, increased the risk factors for cardiac disease as well as the occurrence of cardiac and kidney injury in a way that was quantitatively and qualitatively similar to that observed after TBI. Shielding of the kidneys prevented the increases in risk factors for cardiac disease. Shielding of the intestines did not prevent the increases in risk factors for cardiac disease. There was no histological evidence of liver injury 120 days after irradiation. Injury to the heart from irradiation appears to be indirect, supporting the notion that injury to abdominal organs, principally the kidneys, is responsible for the increased risk factors for and the occurrence of cardiac disease after TBI and LHB irradiation.

  19. Ability of Bacillus mucilaginosus GY03 Strain to Adsorb Chromium Ions

    Institute of Scientific and Technical Information of China (English)

    CHEN Ye; LIAN Bin

    2005-01-01

    A research with Bacillus mucilaginosus cultured in nitrogen-free medium for forming a flocculant material to adsorb Cr+6 was conducted to determine the effects of different pH, volume, treatment time, and chromium (Ⅵ) concentrations on chromium (Ⅵ) adsorption by microbial flocculant (MBF), which was produced from the B. mucilaginosus GY03 strain. The results showed that MBF had outstanding flocculation on chromium (Ⅵ). Based on the results of a oneway experiment and actual wastewater treatment conditions, the optimum conditions, obtained by using orthogonal experiments, for chromium (Ⅵ) adsorption by MBF were: Cr6+ solution pH of 9, flocculant material volume of 15 mL,treatment time of 12 h and chromium ion concentration of 30 mg L-1. The results demonstrated that the MBF produced from GY03 could be used in the chromium-containing wastewater treatment. Meanwhile, after extraction and analysis of the MBF polysaccharides, it was found that MBF was mainly composed of glycoprotein. Analysis on constituents of monosaccharide showed that polysaccharides of B. mucilaginosus were composed of rhamnose, glucose etc. Thus, because it was applied over a wide range of pH, in small amounts and had a rapid flocculation speed the flocculant used in this experiment had a vast field of application potential.

  20. Wholesomeness of food irradiated with doses above 10 kGy

    Energy Technology Data Exchange (ETDEWEB)

    Kaferstein, F. [Director, Programme of Food Safety and Food Aid, WHO, CH-1211, Geneva 27, (Switzerland)

    1997-12-31

    Strictly from the scientific point of view, no ceiling should be set for food irradiated with doses greater than the currently recommended upper level of 10 kGy by the Codex Alimentarius Commission. The food irradiation technology itself is safe to such a degree that as long as sensory qualities of food are retained and harmful microorganisms are destroyed, the actual amount of ionizing radiation applied is of secondary consideration. That was the main conclusion of a week-long meeting on high dose irradiation organized jointly by the World Health Organization (WHO), the United Nations Food and Agriculture Organization (FAO) and the International Atomic Energy Agency (IAEA). The knowledge of what can and does occur chemically in high dose irradiated foods which derives from over 50 years of research tells us that one can go as high as 75 kGy, as has already been done in some countries, and the result is the same food is safe and wholesome and nutritionally adequate. (Author)

  1. Protective effects of cimetidine on micronucleated polychromatic erythrocytes in mice irradiated with 0.7Gy

    Directory of Open Access Journals (Sweden)

    Jun-ling ZHANG

    2016-01-01

    Full Text Available Objective  To study the radioprotective effect of cimetidine on single low-dose irradiated mice with radiosensitive detection indexes. Methods  Forty-eight healthy male C57BL/6 mice were randomly divided into normal control group, model control group, positive group (200mg/kg WR2721 and cimetidine groups (7.5mg/kg, 15mg/kg and 30mg/kg. The mice were given intraperitoneal injection of cimetidine 2h before irradiation in cimetidine groups and WR2721 before irradiation once a day for two days in positive group. All the mice except those in normal control group were irradiated with 0.7Gy 60Co γ-ray at 5.83mGy/min rate. Peripheral blood cells, superoxide dismutase (SOD activity and malondialdehyde (MDA content both in serum and liver, bone marrow DNA content and frequency of micronucleated polychromatic erythrocytes (fMPEs were determined 24h after irradiation. Results  Compared with normal control group, the peripheral white blood cells (WBCs of irradiated mice decreased significantly (P<0.01, and fMPEs increased significantly (P<0.01 after irradiation. Except for 15mg/kg cimetidine group, the bone marrow DNA content was decreased significantly after irradiation (P<0.01, P<0.05. The SOD activity and MDA content in irradiated mice showed no significant difference compared with that of normal mice. Compared with model control group, peripheral WBCs and bone marrow DNA content showed no significant changes in treatment groups. The f MPE of 7.5mg/kg cimetidine group was 0.027‰, which was decreased significantly compared with that of model control group (P<0.01, and the dose reduction factor (DRF of 7.5mg/kg cimetidine group was 3.338. Conclusion  Cimetidine has good protective effect on micronucleated polychromatic erythrocytes (MPEs in mice irradiated by 0.7Gy in single low-dose. DOI: 10.11855/j.issn.0577-7402.2015.12.03

  2. Pierre Gy's sampling theory and sampling practice heterogeneity, sampling correctness, and statistical process control

    CERN Document Server

    Pitard, Francis F

    1993-01-01

    Pierre Gy's Sampling Theory and Sampling Practice, Second Edition is a concise, step-by-step guide for process variability management and methods. Updated and expanded, this new edition provides a comprehensive study of heterogeneity, covering the basic principles of sampling theory and its various applications. It presents many practical examples to allow readers to select appropriate sampling protocols and assess the validity of sampling protocols from others. The variability of dynamic process streams using variography is discussed to help bridge sampling theory with statistical process control. Many descriptions of good sampling devices, as well as descriptions of poor ones, are featured to educate readers on what to look for when purchasing sampling systems. The book uses its accessible, tutorial style to focus on professional selection and use of methods. The book will be a valuable guide for mineral processing engineers; metallurgists; geologists; miners; chemists; environmental scientists; and practit...

  3. Low-dose (10-Gy) total skin electron beam therapy for cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Kamstrup, Maria R; Gniadecki, Robert; Iversen, Lars

    2015-01-01

    is limited to 2 to 3 courses in a lifetime due to skin toxicity. This study aimed to determine the clinical effect of low-dose TSEBT in patients with MF and SS. METHODS AND MATERIALS: In an open clinical study, 21 patients with MF/SS stages IB to IV were treated with low-dose TSEBT over ...: Low-dose (10-Gy) TSEBT offers a high overall response rate and is relatively safe. With this approach, reirradiation at times of relapse or progression is likely to be less toxic than standard dose TSEBT. It remains to be established whether adjuvant and combination treatments can prolong...... the beneficial effects of low-dose TSEBT....

  4. On the Erdős-Gyárfás Conjecture in Claw-Free Graphs

    Directory of Open Access Journals (Sweden)

    Nowbandegani Pouria Salehi

    2014-08-01

    Full Text Available The Erdős-Gyárfás conjecture states that every graph with minimum degree at least three has a cycle whose length is a power of 2. Since this conjecture has proven to be far from reach, Hobbs asked if the Erdős-Gyárfás conjecture holds in claw-free graphs. In this paper, we obtain some results on this question, in particular for cubic claw-free graphs

  5. Graves' disease and radioiodine therapy. Is success of ablation dependent on the achieved dose above 200 Gy?

    Energy Technology Data Exchange (ETDEWEB)

    Kobe, C.; Eschner, W.; Sudbrock, F.; Weber, I.; Marx, K.; Dietlein, M.; Schicha, H. [Dept. of Nuclear Medicine, Univ. of Cologne (Germany)

    2008-07-01

    Aim: this study was performed to determine the results of ablative radioiodine therapy (RIT) when the achieved dose in the thyroid was above 200 Gy and to characterize predictive factors for treatment outcome. Patients, methods: a total of 571 consecutive patients were observed for 12 months between July 2001 and June 2004. Inclusion criteria were a confirmed diagnosis Groves' disease, compensation of hyperthyroidism and withdrawal of antithyroid drugs two days before preliminary radioiodine-testing and RIT. The intended dose was 250 Gy and the therapeutically achieved dose was calculated from serial uptake measurements. The end-point measure was thyroid function 12 months after RIT; success was defined as elimination of hyperthyroidism. The relation between success rate and the achieved dose, thyroid volume, age and sex of patients, TSH- and TRAb-values and presence of ophthalmopathy was analysed. Results: relief from hyperthyroidism was achieved in 96% of patients who received more than 200 Gy, even for thyroid volumes >40 ml. The success of ablative RIT was not influenced by age or sex of patients, or by TSH- or TRAb values or concomitant ophthalmopathy. The mean achieved dose in the thyroid was 298 Gy with a standard deviation of 74.6 Gy. Conclusion: to achieve a dose of over 200 Gy with the above standard deviation, we recommend calculating on intended dose of 250 Gy and using a dosimetric approach with early and late uptake values in the radioiodine test, to allow early therapeutic intervention should the posttherapeutic thyroid dose fall unexpectedly below 200 Gy. (orig.)

  6. eGY-Africa: Addressing the Digital Divide for Science in Africa

    Energy Technology Data Exchange (ETDEWEB)

    Barton, C.E.; /Australian Natl. U., Canberra; Amory-Mazaudier, C.; /Lab.Phys.Plasmas, Saint Maur des Fosses; Barry, B.; /Assoc.African Univ., Accra; Chukwuma; /Olabisi Onabanjo U.; Cottrell, R.L.; /SLAC; Kalim, U.; /Pakistan Natl. U.; Mebrahtu, A.; /Mekelle U.; Petitdidier, M.; /Lab. d' Atmos., Velizy; Rabiu, B.; /Federal Tech. U., Akure; Reeves, C.; /Earthworks bv, Delft

    2010-06-16

    Adoption of information and communication technologies and access to the Internet is expanding in Africa, but because of the rapid growth elsewhere, a Digital Divide between Africa and the rest of the world exists, and the gap is growing. In many sub-Saharan African countries, education and research sector suffers some of the worst deficiencies in access to the Internet, despite progress in development of NRENs - National Research and Education (cyber) Networks. By contrast, it is widely acknowledged in policy statements from the African Union, the UN, and others that strength in this very sector provides the key to meeting and sustaining Millennium Development Goals. Developed countries with effective cyber-capabilities proclaim the benefits to rich and poor alike arising from the Information Revolution. This is but a dream for many scientists in African institutions. As the world of science becomes increasingly Internet-dependent, so they become increasingly isolated. eGY-Africa is a bottom-up initiative by African scientists and their collaborators to try to reduce this Digital Divide by a campaign of advocacy for better institutional facilities. Four approaches are being taken. The present status of Internet services, problems, and plans are being mapped via a combination of direct measurement of Internet performance (the PingER Project) and a questionnaire-based survey. Information is being gathered on policy statements and initiatives aimed at reducing the Digital Divide, which can be used for arguing the case for better Internet facilities. Groups of concerned scientists are being formed at the national, regional levels in Africa, building on existing networks as much as possible. Opinion in the international science community is being mobilized. Finally, and perhaps most important of all, eGY-Africa is seeking to engage with the many other programs, initiatives, and bodies that share the goal of reducing the Digital Divide - either as a direct policy

  7. eGY-Africa: addressing the digital divide for science in Africa

    Science.gov (United States)

    Baki, Paul; Nguno, Anna; Barton, Charles; Amaeshi, Larry; Tenthani, Chifundo; Petitdidier, Monique; Cottrell, Les

    2013-04-01

    Adoption of information and communication technologies and access to the Internet is expanding in Africa, but because of the rapid growth elsewhere, a Digital Divide between Africa and the rest of the world exists. In many sub-Saharan African countries, education and research sector suffers some of the worst deficiencies in access to the Internet, despite progress in the development of NRENs - National Research and Education (cyber) Networks. By contrast, it is widely acknowledged in policy statements from the African Union, the UN, and others that strength in this very sector provides the key to meeting and sustaining Millennium Development Goals. Developed countries with effective cyber-capabilities proclaim the benefits to rich and poor alike arising from the Information Revolution. This is still a dream for many scientists in African institutions. As the world of science becomes increasingly Internet-dependent, so they become increasingly isolated. eGY-Africa is a bottom-up initiative by African scientists and their collaborators to try to reduce this digital divide by a campaign of advocacy for better institutional facilities. Four approaches are being taken. The present status of Internet services, problems, and plans are being mapped via a combination of direct measurement of Internet performance (the PingER Project) and a questionnaire-based survey. Information is being gathered on policy statements and initiatives aimed at reducing the digital divide, which can be used for arguing the case for better Internet facilities. Groups of concerned scientists are being formed at the national, regional levels in Africa, building on existing networks as much as possible. Opinion in the international science community is being mobilized. Finally, and perhaps most important of all, eGY-Africa is seeking to engage with the many other programs, initiatives, and bodies that share the goal of reducing the digital divide - either as a direct policy objective, or indirectly

  8. 100 Gy 60Co γ-Ray Induced Novel Mutations in Tetraploid Wheat

    Directory of Open Access Journals (Sweden)

    Chuntao Yang

    2014-01-01

    Full Text Available 10 accessions of tetraploid wheat were radiated with 100 Gy 60Co γ-ray. The germination energy, germination rate, special characters (secondary tillering, stalk with wax powder, and dwarf, meiotic process, and high-molecular-weight glutenin subunits (HMW-GSs were observed. Different species has different radiation sensibility. With 1 seed germinated (5%, T. dicoccum (PI434999 is the most sensitive to this dose of radiation. With a seed germination rate of 35% and 40%, this dose also affected T. polonicum (As304 and T. carthlicum (As293. Two mutant dwarf plants, T. turgidum (As2255 253-10 and T. polonicum (As302 224-14, were detected. Abnormal chromosome pairings were observed in pollen mother cells of both T. dicoccoides (As835 237-9 and T. dicoccoides (As838 239-8 with HMW-GS 1Ax silent in seeds from them. Compared with the unirradiated seed of T. polonicum (As304 CK, a novel HMW-GS was detected in seed of T. polonicum (As304 230-7 and its electrophoretic mobility was between 1By8 and 1Dy12 which were the HMW-GSs of Chinese Spring. These mutant materials would be resources for wheat breeding.

  9. Behavioural consequences of an 8 Gy total body irradiation in mice: Regulation by interleukin-4

    Energy Technology Data Exchange (ETDEWEB)

    Van der Meeren, A.; Lebaron-Jacobs, L. [Inst. de Protection et de Surete Nucleaire, Dept. de Protection de la sante de l' Homme et de Dosimetrie, Section Autonome de Radiobiologie Appliquee a la Medecine, IPSN, Fontenay-aux-Roses (France)

    2001-02-01

    The effects of an 8 Gy {gamma} total body irradiation (TBI) on exploration and locomotion activities as well as temperature were studied in C57BL6/J mice. Survival, body weight, and blood cell counts were also assessed in irradiated mice treated with placebo or interleukin (IL)-4. The efficacy of IL-4 treatment on improvement in exploration activity was evaluated. The study was carried out from 3 h to 30 days following exposure. Our results showed a biphasic response to irradiation concerning the exploration activity of mice. Irradiated mice had reduced activity as early as 3 h after exposure, with recovery of activity within 24 h. The exploration activity again decreased 4 days after irradiation and the recovery occurred slowly after day 17. IL-4 ameliorated the exploration status in mice in both phases. The locomotion activity was studied using a telemetry apparatus. A similar pattern to that of the exploration data was observed, with a minimal activity observed between days 13 and 17. A radiation-induced hypothermia was also noticed over the same time period. (author)

  10. Rapid Degradation of Phenanthrene by Using Sphingomonas sp. GY2B Immobilized in Calcium Alginate Gel Beads

    Directory of Open Access Journals (Sweden)

    Li-Ni Yang

    2009-09-01

    Full Text Available The strain Sphingomonas sp. GY2B is a high efficient phenanthrene-degrading strain isolated from crude oil contaminated soils that displays a broad-spectrum degradation ability towards PAHs and related aromatic compounds. This paper reports embedding immobilization of strain GY2B in calcium alginate gel beads and the rapid degradation of phenanthrene by the embedded strains. Results showed that embedded immobilized strains had high degradation percentages both in mineral salts medium (MSM and 80% artificial seawater (AS media, and had higher phenanthrene degradation efficiency than the free strains. More than 90% phenanthrene (100 mg·L-1 was degraded within 36 h, and the phenanthrene degradation percentages were >99.8% after 72 h for immobilized strains. 80% AS had significant negative effect on the phenanthrene degradation rate (PDR of strain GY2B during the linear-decreasing stage of incubation and preadsorption of cells onto rice straw could improve the PDR of embedded strain GY2B. The immobilization of strain GY2B possesses a good potential for application in the treatment of industrial wastewater containing phenanthrene and other related aromatic compounds.

  11. Impact of the target volume (prostate alone vs. prostate with seminal vesicles) and fraction dose (1.8 Gy vs. 2.0 Gy) on quality of life changes after external-beam radiotherapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Eble, Michael J. [Dept. of Radiotherapy, RWTH Aachen (Germany); Pinkawa, Michael; Piroth, Marc D.; Fischedick, Karin; Holy, Richard; Klotz, Jens; Nussen, Sandra; Krenkel, Barbara

    2009-11-15

    Purpose: to evaluate the impact of the clinical target volume (CTV) and fraction dose on quality of life (QoL) after external-beam radiotherapy (EBRT) for prostate cancer. Patients and methods: a group of 283 patients has been surveyed prospectively before, at the last day, at a median time of 2 months and 15 months after EBRT (70.2-72 Gy) using a validated questionnaire (Expanded Prostate Cancer Index Composite). FBRT of prostate alone (P, n = 70) versus prostate with seminal vesicles (PS, n = 213) was compared. Differences of fraction doses (1.8 Gy, n = 80, vs. 2.0 Gy, n = 69) have been evaluated in the patient group receiving a total dose of 72 Gy. Results: significantly higher bladder and rectum volumes were found at all dose levels for the patients with PS versus P within the CTV (p < 0.001). Similar volumes resulted in the groups with different fraction doses. Paradoxically, bowel function scores decreased significantly less 2 and 15 months after EBRT of PS versus P. 2 months after EBRT, patients with a fraction dose of 2.0 Gy versus 1.8 Gy reported pain with urination ({>=} once a day in 12% vs. 3%; p = 0.04) and painful bowel movements ({>=} rarely in 46% vs. 29%; p = 0.05) more frequently. No long-term differences were found. Conclusion: the risk of adverse QoL changes after EBRT for prostate cancer cannot be derived from the dose-volume histogram alone. Seminal vesicles can be included in the CTV up to a moderate total dose without adverse effects on QoL. Apart from a longer recovery period, higher fraction doses were not associated with higher toxicity. (orig.)

  12. Enhanced degradation of phenol by Sphingomonas sp. GY2B with resistance towards suboptimal environment through adsorption on kaolinite.

    Science.gov (United States)

    Gong, Beini; Wu, Pingxiao; Huang, Zhujian; Li, Yuewu; Dang, Zhi; Ruan, Bo; Kang, Chunxi; Zhu, Nengwu

    2016-04-01

    The effects of clay minerals on microbial degradation of phenol under unfavorable environmental conditions were investigated. Degradation of phenol by Sphingomonas sp. GY2B adsorbed on kaolinite, montmorillonite, and vermiculite were evaluated in comparison with free bacteria under optimal conditions. Kaolinite was found to be the most effective in accelerating degradation rate (reducing the degradation time) as well as improving degradation efficiency (increasing the percentage of phenol degraded), with GY2B/kaolinite complex achieving a degradation efficiency of 96% within 6 h. GY2B adsorbed on kaolinite was more competent than free GY2B in degradation under conditions with high phenol concentrations and at alkaline pH. Kaolinite reduced the time required for degradation by 8-12 h and improved the degradation efficiency by as much as 82% at high phenol concentrations. Meanwhile, the GY2B/kaolinite complex reduced the degradation time by 24 h and improved the degradation efficiency by 46% at pH 12. The improvement was partially due to the buffering effects of kaolinite. It was also shown that Cr(VI) and kaolinite synergistically enhanced the degradation by GY2B, with Cr(VI) and kaolinite both increasing the degradation rate and kaolinite being primarily responsible for enhanced degradation efficiency. These results showed one of the common clay minerals, kaolinite, is able to significantly improve the microbial degradation performance, and protect microorganisms against unfavorable environment. Kaolinite can collaborate with Cr(VI) to further improve the microbial degradation performance. It is implied that clay minerals have great potential to be applied in enhancing the biodegradation of phenol.

  13. Phase 2 Trial of Accelerated, Hypofractionated Whole-Breast Irradiation of 39 Gy in 13 Fractions Followed by a Tumor Bed Boost Sequentially Delivering 9 Gy in 3 Fractions in Early-Stage Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ja Young [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Jung, So-Youn; Lee, Seeyoun; Kang, Han-Sung; Lee, Eun Sook; Park, In Hae; Lee, Keun Seok; Ro, Jungsil [Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Lee, Nam Kwon [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Department of Radiation Oncology, Korea University Medical Center, Collage of Medicine, Seoul (Korea, Republic of); Shin, Kyung Hwan, E-mail: radiat@ncc.re.kr [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Department of Radiation Oncology, Korea University Medical Center, Collage of Medicine, Seoul (Korea, Republic of)

    2013-12-01

    Purpose: To report a phase 2 trial of accelerated, hypofractionated whole-breast irradiation (AH-WBI) delivered as a daily dose of 3 Gy to the whole breast followed by a tumor bed boost. Methods and Materials: Two hundred seventy-six patients diagnosed with breast cancer (pT1-2 and pN0-1a) who had undergone breast-conserving surgery in which the operative margins were negative were treated with AH-WBI delivered as 39 Gy in 13 fractions of 3 Gy to the whole breast once daily over 5 consecutive working days, and 9 Gy in 3 sequential fractions of 3 Gy to a lumpectomy cavity, all within 3.2 weeks. Results: After a median follow-up period of 57 months (range: 27-75 months), the rate of 5-year locoregional recurrence was 1.4% (n=4), whereas that of disease-free survival was 97.4%. No grade 3 skin toxicity was reported during the follow-up period. Qualitative physician cosmetic assessments of good or excellent were noted in 82% of the patients at 2 months after the completion of AH-WBI. The global cosmetic outcome did not worsen over time, and a good or excellent cosmetic outcome was reported in 82% of the patients at 3 years. The mean pretreatment percentage breast retraction assessment was 12.00 (95% confidence interval [CI]: 11.14-12.86). The mean value of percentage breast retraction assessment increased to 13.99 (95% CI: 12.17-15.96) after 1 year and decreased to 13.54 (95% CI: 11.84-15.46) after 3 years but was not significant (P>.05). Conclusions: AH-WBI consisting of 39 Gy in 13 fractions followed by a tumor bed boost sequentially delivering 9 Gy in 3 fractions can be delivered with excellent disease control and tolerable skin toxicity in patients with early-stage breast cancer after breast-conserving surgery.

  14. Tururadikalism ja selle ohvrid / György Schöpflin ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Schöpflin, György, 1939-

    2008-01-01

    György Matolcsy raamatust Ellovasbol Sereghajto: elveszett evek kronikaja ["Eelväest järelväkke: kaotatud aastate kroonika"], mis näitab, mida võib tururadikalism korda saata majanduslikult nõrkades ja poliitiliselt oskamatult juhitud riikides

  15. Minerals sampling: sensibility analysis and correction factors for Pierre Gy's equation; Muestreo de minerales: analisis de sensibilidad y factores de correccion para la ecuacion de Pierre Gy

    Energy Technology Data Exchange (ETDEWEB)

    Vallebuona, G.; Niedbalski, F.

    2005-07-01

    Pierre Gy's equation is widely used in ore sampling. This equation is based in four parameters: shape factor, size distribution factor, mineralogical factor and liberation factor. The usual practice is to consider fixed values for the shape and size distribution factors. This practice does not represent well several important ores. The mineralogical factor considers only one specie of interest and the gangue, leaving out other cases such as polymetallic ores where there are more than one species of interest. A sensibility analysis to the Gy's equation factors was done and a procedure to determine specific values for them was developed and presented in this work. mean ore characteristics, associated with an insecure use of the actual procedure, were determined. finally, for a case study, the effects of using each alternative were evaluated. (Author) 4 refs.

  16. Conformal radiotherapy to 76 Gy in localized prostate cancer. Therapeutic modalities and preliminary results; Radiotherapie conformationnelle a 76 Gy des cancers localises de la prostate. Modalites therapeutiques et resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Pontvert, D.; Mammar, H. [Institut Curie, Dept. d' Oncologie Radiotherapique, 75 - Paris (France); Flam, T.; Debre, B. [Hopital Cochin-Saint-Vincent-de-Paul, Service d' Urologie, 75 - Paris (France); Thiounn, N. [Hopital Necker-Enfants-Malades, Service d' Urologie, 75 - Paris (France); Gaboriaud, G. [Institut Curie, Service de Physique Medicale, 75 - Paris (France); Jourdan-Da Silvae, N. [Institut Curie, Service de Biostatistique et d' evaluation clinique, 75 - Paris (France); Beuzeboc, P. [Institut Curie, Dept. d' Oncologie Medicale, 75 - Paris (France)

    2008-03-15

    Purpose: to describe therapeutic modalities for localized prostate cancer treated by conformal radiation to 76 Gy with or without androgen ablation. To evaluate the preliminary results in terms of survival, biological control and toxicity. Patients and method: between January 1998 and June 2001, 321 patients with localized prostate cancer were irradiated at Institut Curie. Tumors were stratified into the three Memorial Sloan-Kettering Cancer Center prognostic groups (1998) for analysis: favorable risk group (F.G.) 23%, intermediate risk group (I.G.) 36.5%, unfavorable risk group (U.G.) 40.5%. Androgen deprivation, mainly neo-adjuvant, less or equal to one year was prescribed to 93.8% of patients (72.6% less or equal to six months). Planning target volume prescription doses were: prostate: 76 Gy, seminal vesicles: 56 to 76 Gy, and pelvic lymph nodes: 44 Gy to 16.8% of patients. Results: the five-year actuarial overall survival was 94% (95% I.C.: 90-97%). The median post-therapeutic follow-up was 36 months (nine to 60 months). The 48-month actuarial rates of biochemical control for the three prognostic groups were statistically different according to both the American Society for Therapeutic Radiology and Oncology consensus (A.S.T.R.O. 1997) and the Fox Chase Cancer Center definitions of biochemical failure (F.C.C.C. 2000) with respectively 87 and 94% for F.G., 78 and 84% for I.G., 54 and 58% for U.G. (P < 10-6 and P < 10-8). At time of our analysis, late post-treatment rectal and bladder bleedings were 17,4 and 13,6%, respectively. According to a 1-4 scale adapted from M.D. Anderson Cancer Center criteria: rectal bleedings were grade 1 (9.6%), grade 2 (6.2%) and grade 3 (1.6%). Bladder bleedings were grade 2 (13%) and grade 3 (0.6%). Analysis of rectal bleeding risk factors showed significant correlations with pelvic lymph nodes irradiation for grade 2 and 3, (P = 0.02), and for all grades, a correlation with smaller rectal wall volumes (P = 0.03), and greater

  17. Experimental analysis of quasi-static and dynamic fracture initiation toughness of gy4 armor steel material

    Science.gov (United States)

    Ren, Peng; Guo, Zitao

    Quasi-static and dynamic fracture initiation toughness of gy4 armour steel material are investigated using three point bend specimen. The modified split Hopkinson pressure bar (SHPB) apparatus with digital image correlation (DIC) system is applied to dynamic loading experiments. Full-field deformation measurements are obtained by using DIC to elucidate on the strain fields associated with the mechanical response. A series of experiments are conducted at different strain rate ranging from 10-3 s-1 to 103 s-1, and the loading rate on the fracture initiation toughness is investigated. Specially, the scanning electron microscope imaging technique is used to investigate the fracture failure micromechanism of fracture surfaces. The gy4 armour steel material fracture toughness is found to be sensitive to strain rate and higher for dynamic loading as compared to quasi-static loading. This work is supported by National Nature Science Foundation under Grant 51509115.

  18. James P. Allison received the 2014 Szent-Györgi Prize for Progress in Cancer Research

    Institute of Scientific and Technical Information of China (English)

    Jie Zhao,Peter Scully; Sujuan Ba

    2014-01-01

    The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that is committed to supporting innovative cancer research on the global scale that aims to cure cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher whose original discoveries have expanded our understanding of cancer and resulted in notable advances in cancer prevention, diagnosis, or treatment. The prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the history and mission of the Szent-Györgyi Prize, its role in promoting discovery-oriented cancer research, and the pioneering work led by the 2014 prize winner, Dr. James Alison. Dr. Alison’s work in the area of cancer immunotherapy led to the successful development of immune checkpoint therapy, and the first drug approved by the United States Food and Drug Administration for the treatment of metastatic melanoma.

  19. Thermoluminescence (TL) Analysis and Fading Studies of Naturally Occurring Salt Irradiated by 500 mGy Gamma Rays

    Science.gov (United States)

    Tiwari, Ramesh Chandra; Pau, Kham Suan

    2011-10-01

    The aim of the present study was to investigate the potential of the naturally occurring salt for the dosimetry purposes, using TL. The fine powder samples (20 mg) were irradiated by γ- rays from 500 mGy to 2500 mGy by using Theratron-780C Cobalt-60 source, however, this paper discusses about 500 mGy only. The TL glow curve peak parameters were studied by using Chen's peak shape equation. TL glow curves were compared with fitted curves using glow curve deconvolution (GCD) method by using Kitis expression. The kinetic parameter values (E, b and s) so calculated, are in good agreement with those available in literature. The calculated energy values were also verified by using various heating rate (VHR) method. χ2 test and figure of merit (FOM) calculation was done to accept the goodness of fit between the curves. Fading studies of the sample showed a good fitting between the curves. The analysis suggests that natural salt should be considered for dosimetry purposes.

  20. EFFECT OF CULTURE CONDITIONS ON POLY( VINYLALCOHOL)-DEGRADING ENZYME PRODUCTION BY STREPTOMYCES VENEZUELAE GY1%Streptomyces venezuelae GY1产聚乙烯醇降解酶的培养条件

    Institute of Scientific and Technical Information of China (English)

    张颖; 李寅; 华兆哲; 陈坚

    2005-01-01

    放线菌Streptomyces venezuelae GY1产生的聚乙烯醇(PVA)降解酶是一种诱导酶.以4种不同类型的PVA为唯一碳源时,该菌株单位质量细胞产酶能力比以糖类物质为唯一碳源时提高10倍以上.聚合度和醇解度最高的PVA1799是该菌株产生PVA降解酶的适宜底物,其浓度为1 g L-1时,PVA降解酶的产量为120 u/g(细胞).培养基中PVA1799浓度由1 g L-1上升到5 g L-1时,该菌株单位质量细胞产酶能力下降73%,表明PVA1799浓度过高会抑制产酶.GY1菌株产酶的最适温度和pH分别为30℃和7.0.在GY1菌株生长过程中控制以下条件有利于产生PVA降解酶:(1)保持培养体系中较高的溶氧水平;(2)在氮源中补充NO3-;(3)在一定浓度范围内添加MgSO4·7H2O、CaCl2、MnSO4、BaCl2、ZnSO4、FeSO4·7H2O和CuSO4等金属盐.Pseudomonas sp.产生的PVA降解酶能够作用伯醇或仲醇类化合物,以这些伯醇或仲醇类化合物代替培养基中的PVA,不能诱导GY1菌株产生PVA降解酶;而在培养基中有PVA存在时,再添加0.5 g L-1的3-戊醇和环己醇能够明显促进PVA降解酶的产生(单位质量细胞产酶能力分别提高了21%和32%).图8表1参10

  1. Exposure to low doses (20 cGy) of Hze results in spatial memory impairment in rats.

    Science.gov (United States)

    Britten, Richard; Johnson, Angela; Davis, Leslie; Green-Mitchell, Shamina; Chabriol, Olivia; Sanford, Larry; Drake, Richard

    INTRODUCTION. Current models predict that the astronauts on a mission to a deep space destination, such as Mars, will be exposed to 25 cGy of Galactic cosmic radiation (GCR). The long-term consequence of exposure to such doses is largely unknown, but given that 1.3 Gy of X-rays has been reported to lead to long-term cognitive deficits (Shore et al, 1976) and that CGR have an RBE of 2-5, it is likely that the predicted 25 cGy of GCR will lead to defects in the cognitive ability of the astronauts during and after the mission. Our studies are designed to help define the GCR dose that will lead to defects in complex working memory, and also to elucidate the mechanisms whereby hadronic radiation diminishes neurocognitive function. The identification of such processes would provide an opportunity for post-mission surveillance, and hopefully will lead to intervention strategies that will ameliorate or attenuate GCR-induced neurocognitive deficits. MATERIALS METHODS. Four-week old male Wistar rats were exposed to either X-rays or 1 GeV 56Fe. At three or six months post exposure the performance of the rats in the Barnes' Maze (Spatial memory) was established. The duration and frequency of REM sleep was also monitored to determine if the neurocognitive deficits arose due to reduced memory consolidation as a result of diminished REM sleep. We used a novel, but maturing technique, called MALDI-MS imaging (or MALDI-MSI), to identify specific regions of the brain where the neuroproteome differs in rats that have developed spatial memory impairments. RESULTS. 11.5 Gy of X-rays led to reduced performance in the Barnes's maze. In contrast, exposure to 20 cGy of Hze (1 GeV 56Fe) resulted in a significant impairment of spatial memory performance as measured in the Barnes' Maze, which was manifested by an increase in relative escape latency REL over a 5 day testing period. Such an increase in REL could arise from the rats becoming less able, or perhaps less willing, to locate the

  2. Treatment outcome of localized prostate cancer by 70 Gy hypofractionated intensity-modulated radiotherapy with a customized rectal balloon

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Jung; Kim, Jun Won; Hong, Sung Joon; Rha, Koon Ho; Lee, Chang Geol; Yang, Seung Choul; Choi, Young Deuk; Suh, Chang Ok; Cho, Jae Ho [Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2014-09-15

    We aimed to analyze the treatment outcome and long-term toxicity of 70 Gy hypofractionated intensity-modulated radiotherapy (IMRT) for localized prostate cancer using a customized rectal balloon. We reviewed medical records of 86 prostate cancer patients who received curative radiotherapy between January 2004 and December 2011 at our institution. Patients were designated as low (12.8%), intermediate (20.9%), or high risk (66.3%). Thirty patients received a total dose of 70 Gy in 28 fractions over 5 weeks via IMRT (the Hypo-IMRT group); 56 received 70.2 Gy in 39 fractions over 7 weeks via 3-dimensional conformal radiotherapy (the CF-3DRT group, which served as a reference for comparison). A customized rectal balloon was placed in Hypo-IMRT group throughout the entire radiotherapy course. Androgen deprivation therapy was administered to 47 patients (Hypo-IMRT group, 17; CF-3DRT group, 30). Late genitourinary (GU) and gastrointestinal (GI) toxicity were evaluated according to the Radiation Therapy Oncology Group criteria. The median follow-up period was 74.4 months (range, 18.8 to 125.9 months). The 5-year actuarial biochemical relapse-free survival rates for low-, intermediate-, and high-risk patients were 100%, 100%, and 88.5%, respectively, for the Hypo-IMRT group and 80%, 77.8%, and 63.6%, respectively, for the CF-3DRT group (p < 0.046). No patient presented with acute or late GU toxicity > or =grade 3. Late grade 3 GI toxicity occurred in 2 patients (3.6%) in the CF-3DRT group and 1 patient (3.3%) in the Hypo-IMRT group. Hypo-IMRT with a customized rectal balloon resulted in excellent biochemical control rates with minimal toxicity in localized prostate cancer patients.

  3. A prospective study of the early clinical symptoms following a 2 Gy therapeutic whole-body irradiation; Etude prospective de la symptomatologie clinique precoce apres irradiation corporelle totale therapeutique de 2 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Fizazi, K.; Chaillet, M.P.; Fourquet, A.; Jammet, P.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

    1995-10-01

    Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospectively evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16*61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injected intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69%), headache (62%), xerostomia (62%), nausea and vomiting (46%), anorexia (38%), parotid gland pain (23%) and abdominal pain (8%). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irradiation. In particular, absence of fever at the 6{sup th} h after TBI supports the assumption of an estimated exposure dose below 2 Gy. (authors). 23 refs., 2 tabs.

  4. A cyanocobalamin dosimeter for monitoring gamma-radiation doses of 0.1-2 kGy

    Science.gov (United States)

    Maged, A. F.; Hamza, M. S. A.; Saad, E. A.

    1997-08-01

    A simple dosimeter is described for measuring gamma-ray doses useful for insect sterilization, seed-sprouting inhibition and food shelf-life extensions. The red aqueous solution of cyanocobalamin (B 12) before irradiation, assumes a stable yellow color when irradiated. It shows a linear response of absorbance decrease with the dose over the range of 0.1-2.0 kGy when the concentration of cyanocobalamin is equal 0.09 mM. The radiation-induced color is analyzed spectrophotometrically at the maximum absorption band (361 nm). The absorption spectra, dose response and post-irradiation stability of the dosimeter are discussed.

  5. A cyanocobalamin dosimeter for monitoring gamma-radiation doses of 0.1-2 kGy

    Energy Technology Data Exchange (ETDEWEB)

    Maged, A.F. [National Centre for Radiation Research and Technology, Cairo (Egypt); Hamza, M.S.A.; Saad, E.A. [Ain Shams Univ., Cairo (Egypt). Faculty of Science

    1997-08-01

    A simple dosimeter is described for measuring gamma-ray doses useful for insect sterilization, seed-sprouting inhibition and food shelf-life extension. The red aqueous solution of cyanocobalamin (B{sub 12}) before irradiation, assumes a stable yellow color when irradiated. It shows a linear response of absorbance decrease with the dose over the rage of 0.1-2.0 kGy when the concentration of cyanocobalamin is equal 0.09 mM. The radiation-induced color is analyzed spectrophotometrically at the maximum absorption band (361 nm). The absorption spectra, dose response and post-irradiation stability of the dosimeter are discussed. (author).

  6. Plan estratégico de gestión humana en STRACON GyM S.A.

    OpenAIRE

    Zárate Cerna, Jonathan; Zumarán Nunura, Sandro

    2015-01-01

    Trabajo de investigación (Magíster en Desarrollo Organizacional y Dirección de Personas) -- Universidad del Pacífico, Escuela de Postgrado, 2015. Asesor: José Díaz Ismodes. El presente trabajo tiene como alcance la elaboración de un plan estratégico de recursos humanos para ser implementado en la empresa STRACON GyM durante el periodo comprendido entre los años 2015 y 2019. Como base metodológica no se contempla la recolección de muestras desde la perspectiva del enfoque cuantitativo, p...

  7. Early Side Effects of Three-Dimensional Conformal External Beam Accelerated Partial Breast Irradiation to a Total Dose of 40 Gy in One Week (A Phase II Trial)

    Energy Technology Data Exchange (ETDEWEB)

    Bourgier, Celine, E-mail: bourgier@igr.fr [Department of Radiation Oncology, Institut Gustave Roussy, Villejuif (France); Pichenot, Charlotte; Verstraet, Rodolfe [Department of Physics, Institut Gustave Roussy, Villejuif (France); El Nemr, Mohamed; Heymann, Steve [Department of Radiation Oncology, Institut Gustave Roussy, Villejuif (France); Biron, Bruno [Department of Physics, Institut Gustave Roussy, Villejuif (France); Delaloge, Suzette [Department of Breast Oncology, Institut Gustave Roussy, Villejuif (France); Mathieu, Marie-Christine [Department of Pathology, Institut Gustave Roussy, Villejuif (France); Garbay, Jean-Remy [Department of Breast Surgery, Institut Gustave Roussy, Villejuif (France); Bourhis, Jean [Department of Radiation Oncology, Institut Gustave Roussy, Villejuif (France); Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Marsiglia, Hugo [Department of Radiation Oncology, Institut Gustave Roussy, Villejuif (France); Radiotherapy Unit, University of Florence, Florence (Italy)

    2011-12-01

    Purpose: Several accelerated partial breast irradiation (APBI) techniques are described in the literature, and apparently, the three-dimensional (3D)-conformal technique is being used increasingly. Nonetheless, the optimal radiation dose is not yet known. Here, we report feasibility and early toxicities of APBI delivering 40 Gy over 5 days, in a phase II trial. Methods and Materials: From October 2007 to September 2008, 25 patients with pT1N0 cancer received 3D-conformal APBI. The prescribed radiation dose was 40 Gy in 4-Gy fractions given twice daily. This technique used two minitangents and an 'en face' electron field. Toxicities were systematically assessed at 1, 2, and 6 months and then once every 6 months. Results: The planning tumor volume for evaluation (PTV{sub E}VAL) coverage was adequate: the mean dose to the PTV{sub E}VAL was 41.8 Gy (range, 41-42.4 Gy). Mean doses to the ipsilateral lung and heart were 1.6 Gy (range, 1.0-2.3 Gy) and 1.2 Gy (range, 1.0-1.6 Gy), respectively. One and two months after completion of APBI, most patients had no or mild erythema (n = 16 patients at 1 month; n = 25 patients at 2 months); none of these patients developed moist desquamation. After a median follow-up of 12 months, only 1 patient had a significant moderate field contracture (grade 2). Other reported late toxicities were grade 1. Conclusions: 3D-conformal APBI (with two minitangents and an 'en face' electron field) using a total dose of 40 Gy in 10 fractions twice daily over 5 days achieved appropriate PTV{sub E}VAL coverage and offered significant sparing of normal tissue. Early tolerance was excellent.

  8. Hyperfractionated accelerated radiotherapy with concomitant integrated boost of 70-75 Gy in 5 weeks for advanced head and neck cancer. A phase I dose escalation study

    Energy Technology Data Exchange (ETDEWEB)

    Cvek, J.; Skacelikova, E.; Otahal, B.; Halamka, M.; Feltl, D. [University Hospital Ostrava (Czech Republic). Dept. of Oncology; Kubes, J. [University Hospital Bulovka, Prague (Czech Republic). Dept. of Radiation Oncology; Kominek, P. [University Hospital Ostrava (Czech Republic). Dept. of Otolaryngology

    2012-08-15

    Background and purpose: The present study was performed to evaluate the feasibility of a new, 5-week regimen of 70-75 Gy hyperfractionated accelerated radiotherapy with concomitant integrated boost (HARTCIB) for locally advanced, inoperable head and neck cancer. Methods and materials: A total of 39 patients with very advanced, stage IV nonmetastatic head and neck squamous cell carcinoma (median gross tumor volume 72 ml) were included in this phase I dose escalation study. A total of 50 fractions intensity-modulated radiotherapy (IMRT) were administered twice daily over 5 weeks. Prescribed total dose/dose per fraction for planning target volume (PTV{sub tumor}) were 70 Gy in 1.4 Gy fractions, 72.5 Gy in 1.45 Gy fractions, and 75 Gy in 1.5 Gy fractions for 10, 13, and 16 patients, respectively. Uninvolved lymphatic nodes (PTV{sub uninvolved}) were irradiated with 55 Gy in 1.1 Gy fractions using the concomitant integrated boost. Results: Acute toxicity was evaluated according to the RTOG/EORTC scale; the incidence of grade 3 mucositis was 51% in the oral cavity/pharynx and 0% in skin and the recovery time was {<=} 9 weeks for all patients. Late toxicity was evaluated in patients in complete remission according to the RTOG/EORTC scale. No grade 3/4 late toxicity was observed. The 1-year locoregional progression-free survival was 50% and overall survival was 55%. Conclusion: HARTCIB (75 Gy in 5 weeks) is feasible for patients deemed unsuitable for chemoradiation. Acute toxicity was lower than predicted from radiobiological models; duration of dysphagia and confluent mucositis were particularly short. Better conformity of radiotherapy allows the use of more intensive altered fractionation schedules compared with older studies. These results suggest that further dose escalation might be possible when highly conformal techniques (e.g., stereotactic radiotherapy) are used.

  9. Ammonia formation and W coatings interaction with deuterium/nitrogen plasmas in the linear device GyM

    Science.gov (United States)

    Laguardia, L.; Caniello, R.; Cremona, A.; Dellasega, D.; Dell'Era, F.; Ghezzi, F.; Gittini, G.; Granucci, G.; Mellera, V.; Minelli, D.; Pallotta, F.; Passoni, M.; Ricci, D.; Vassallo, E.

    2015-08-01

    In this work results of the first D2/N2 experiments in GyM, a linear device able to produce plasmas of interest for the ITER divertor (ne 5 ṡ 1010 cm-3, Te 5 eV, ion flux 3-5 ṡ 1020 m-2s-1) are presented. Plasmas simulating a N-seeding scenario have been performed to evaluate ammonia formation and its effect on exposed W coatings. The presence of ND emission lines in the plasma can be correlated with the formation of ammonia, further directly detected and quantified by chromatography analysis of the exhaust. Four different W specimens were exposed in GyM to a plasma fluence of 8.78 ṡ 1023 m-2. XPS analysis evidenced the formation of WxNy layers with nitrogen concentration in the range of 1-10% depending on the initial morphology and structure of the W samples. In all analyzed cases, nitrogen was bound and retained within the first 6 nm below the surface and no further diffusion of N into the bulk was observed.

  10. Frederick W. Alt received the 2015 Szent-Györgi Prize forProgress inCancer Research

    Institute of Scientific and Technical Information of China (English)

    PeterScully; JieZhao; SujuanBa

    2016-01-01

    The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientiifc award established by the National Foundation for Cancer Research (NFCR)—a leading cancer research charitable organization in the United States that is committed to supporting scientiifc research and public education relating to the prevention, early diagnosis, better treatments, and ultimately, a cure for cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher, nominated by colleagues or peers, who has contributed outstanding, signiifcant research to the ifght against cancer, and whose accomplishments have helped improve treatment options for cancer patients. The Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the pio-neering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt’s work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene ampliifcation and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.

  11. Analysis of hematopoiesis in mice irradiated with 500 mGy of X rays at different stages of development

    Energy Technology Data Exchange (ETDEWEB)

    Grande, T.; Bueren, J.A. [U. de Biologia Molecular y Celular, Madrid (Spain)

    1995-09-01

    We have investigated whether a relatively low dose of 500 mGy of X rays given as a single acute irradiation at different stages of pre-and postnatal development induces significant changes in the content of femoral hematopoietic progenitores during a 1-year period after irradiation. Data obtained show that, in the case of 4-day-old embryos as well as in 2-day, 8-day and 12-week-old mice, this dose is below the threshold capable of inducing a long-term impairment of hematopoiesis in the mouse. Nevertheless, in mice irradiated at the 13th or the 17th day postconception, a hematopoietic dysfunction consisting of a significant reduction in the proportion of femoral granulocyte-macrophage colony-forming units (CFU-GM) was manifested 1 year after irradiation. Our study confirms that, for most stages of development in the mouse, a single acute X irradiation of 500 mGy is below the threshold dose capable of inducing deterministic effects in the mouse hematopoietic system, although it reveals the induction of a significant impairment in the CFU-GM population when irradiation is given at the late stages of embryonic development. 24 refs., 4 figs.

  12. Ammonia formation and W coatings interaction with deuterium/nitrogen plasmas in the linear device GyM

    Energy Technology Data Exchange (ETDEWEB)

    Laguardia, L., E-mail: laguardia@ifp.cnr.it [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy); Caniello, R.; Cremona, A. [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy); Dellasega, D. [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy); Politecnico di Milano, Dipartimento di Energia, Milan (Italy); Dell’Era, F.; Ghezzi, F.; Gittini, G.; Granucci, G.; Mellera, V.; Minelli, D.; Pallotta, F. [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy); Passoni, M. [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy); Politecnico di Milano, Dipartimento di Energia, Milan (Italy); Ricci, D.; Vassallo, E. [CNR, Istituto di Fisica del Plasma“P. Caldirola”, Milan (Italy)

    2015-08-15

    In this work results of the first D{sub 2}/N{sub 2} experiments in GyM, a linear device able to produce plasmas of interest for the ITER divertor (n{sub e} 5 ⋅ 10{sup 10} cm{sup −3}, Te 5 eV, ion flux 3–5 ⋅ 10{sup 20} m{sup −2}s{sup −1}) are presented. Plasmas simulating a N-seeding scenario have been performed to evaluate ammonia formation and its effect on exposed W coatings. The presence of ND emission lines in the plasma can be correlated with the formation of ammonia, further directly detected and quantified by chromatography analysis of the exhaust. Four different W specimens were exposed in GyM to a plasma fluence of 8.78 ⋅ 10{sup 23} m{sup −2}. XPS analysis evidenced the formation of W{sub x}N{sub y} layers with nitrogen concentration in the range of 1–10% depending on the initial morphology and structure of the W samples. In all analyzed cases, nitrogen was bound and retained within the first 6 nm below the surface and no further diffusion of N into the bulk was observed.

  13. Feasibility of safe ultra-high (EQD{sub 2}>100 Gy) dose escalation on dominant intra-prostatic lesions (DILs) by Helical Tomotheraphy

    Energy Technology Data Exchange (ETDEWEB)

    Maggio, Angelo; Fiorino, Claudio; Mangili, Paola; Cattaneo, Giovanni Mauro; Del Maschio, Alessandro; Calandrino, Riccardo (Medical Physics, San Raffaele Scientific Inst., Milano (Italy)), e-mail: fiorino.claudio@hsr.it; Muzio, Nadia Di; Cozzarini, Cesare (Radiotherapy, San Raffaele Scientific Inst., Milano (Italy)); Cobelli, Francesco de (Radiology, San Raffaele Scientific Inst., Milano (Italy)); Rancati, Tiziana (Programma Prostata, National Inst. of Cancer, Milano (Italy))

    2011-01-15

    Purpose. To verify the possibility of using Helical Tomotherapy to safely escalate dose to single or multiple highly radioresistant dominant intra-prostatic lesions (DILs) as assessed by functional magnetic resonance imaging (MRI). Material. In seven intermediate/high risk patients, T2WI, T1WI and DWI MRI imaging showed evidence of one DIL in four patients and two DILs in three patients in the peripheral zone of the prostate. The planning strategy was to deliver median doses of 80, 90, 100 and 120 Gy to PTVDIL while delivering 71.4 Gy/28 fractions (EQD{sub 2}=75 Gy) to the remaining portion of PTV. A higher priority was assigned to rectal constraints relative to DIL coverage. Rectal NTCP calculations were performed using the most recently available model data. Results. The median dose to DIL could safely be escalated to at least 100 Gy (EQD{sub 2,{alpha}/{beta}=10}=113 Gy) without violating safe constraints for the organs at risk. Typical rectal NTCP values were around or below 1-3% for G3 toxicity and 5-7% for G2-G3 toxicity. For the 100 Gy DIL dose boost strategy, mean D95% of DIL and PTVDIL were 98.8 Gy and 86.7 Gy, respectively. The constraints for bladder, urethra and femoral heads were always respected. Conclusions. IGRT by Helical Tomotherapy may permit the safe escalation of EQD{sub 2,{alpha}/{eta}=10} to at least 113 Gy to DILs without significantly increasing rectal NTCP compared to plans without dose escalation. A Phase I-II clinical study is warranted

  14. Standard (60 Gy) or Short-Course (40 Gy) Irradiation Plus Concomitant and Adjuvant Temozolomide for Elderly Patients With Glioblastoma: A Propensity-Matched Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Minniti, Giuseppe, E-mail: gminniti@ospedalesantandrea.it [Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome (Italy); Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Neuromed, Pozzilli (Italy); Scaringi, Claudia [Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome (Italy); Lanzetta, Gaetano [Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Neuromed, Pozzilli (Italy); Terrenato, Irene [Biostatistic Unit, Regina Elena National Cancer Institute, Rome (Italy); Esposito, Vincenzo; Arcella, Antonella [Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Neuromed, Pozzilli (Italy); Pace, Andrea [Neurology Unit, Regina Elena National Cancer Institute, Rome (Italy); Giangaspero, Felice [Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Neuromed, Pozzilli (Italy); Bozzao, Alessandro [Neuroradiology Unit, Sant' Andrea Hospital, University Sapienza, Rome (Italy); Enrici, Riccardo Maurizi [Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome (Italy)

    2015-01-01

    Purpose: To evaluate 2 specific radiation schedules, each combined with temozolomide (TMZ), assessing their efficacy and safety in patients aged ≥65 years with newly diagnosed glioblastoma (GBM). Methods and Materials: Patients aged ≥65 years with Karnofsky performance status (KPS) ≥60 who received either standard (60 Gy) or short-course (40 Gy) radiation therapy (RT) with concomitant and adjuvant TMZ between June 2004 and October 2013 were retrospectively analyzed. A propensity score analysis was executed for a balanced comparison of treatment outcomes. Results: A total of 127 patients received standard RT-TMZ, whereas 116 patients underwent short-course RT-TMZ. Median overall survival and progression-free survival times were similar: 12 months and 5.6 months for the standard RT-TMZ group and 12.5 months and 6.7 months for the short-course RT-TMZ group, respectively. Radiation schedule was associated with similar survival outcomes in either unadjusted or adjusted analysis. O{sup 6}-methylguanine-DNA methyltransferase promoter methylation was the most favorable prognostic factor (P=.0001). Standard RT-TMZ therapy was associated with a significant rise in grade 2 and 3 neurologic toxicity (P=.01), lowering of KPS scores during the study (P=.01), and higher posttreatment dosing of corticosteroid (P=.02). Conclusions: In older adults with GBM, survival outcomes of standard and short-course RT-TMZ were similar. An abbreviated course of RT plus TMZ may represent a reasonable therapeutic approach for these patients, without loss of survival benefit and acceptable toxicity.

  15. Tri-LORE-gy

    DEFF Research Database (Denmark)

    Mun, Terry

    Lotus japonicus is a model legume widely used in the study of plant development, physiology, and host-microbe interactions. The provision of genomic and transcriptomic data, the availability of a large mutant collection generated from saturation mutagenesis by an activated endogenous LTR retrotra...

  16. Three dimensional conformal photon radiotherapy at a moderate dose level of 66 Gy for prostate carcinoma: early results

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, S.; Gerstner, N.; Goldner, G.; Dieckmann, K.; Colotto, A.; Poetter, R. [Dept. of Radiotherapy and Radiobiology, Univ. Hospital Vienna (Austria)

    1999-06-01

    We present our experience of 291 patients treated between January 1994 and August 1997 with a 3-D planned four-field box technique and a central dose of 66 Gy. Biochemical response of patients with radiotherapy alone (group 1, n=72 pts.) has been analyzed in detail. Acute radiation side effects are given for all patients (n=291), late radiation side effects are given for patients treated between Jan 1994 and Jan 1996 with a median follow-up of 22 months (n=115 pts). Results: We have observed a biochemical response (nadir PSA < 1 after 12 months, < 2 after 6 months) for patients treated with radiotherapy alone without hormone manipulation in 67%. Incidence of late rectal and bladder morbidity (grade 2 and 3) was 9.4% and 4%, respectively. (orig.)

  17. Identification of microbial isolates from vacuum-packaged ground pork irradiated at 1 kGy. [Pseudomonas sp. ; Enterobacter sp

    Energy Technology Data Exchange (ETDEWEB)

    Ehioba, R.M.; Kraft, A.A.; Molins, R.A.; Walker, H.W.; Olson, D.G.; Subbaraman, G.; Skowronski, R.P.

    Bacterial cultures from irradiated (1 kGy) and nonirradiated, vacuum-packaged ground pork held at 5/sup 0/C were isolated and characterized over a 12-day storage period. The initial flora of the meat was composed mostly of Pseudomonas sp., and Enterobacter sp. Although the microflora of nonirradiated samples gradually shifted from Gram-negative to Gram-positive microorganisms, 76% of the isolates were characterized as Gram-negative at the onset of spoilage (9 days at 5/sup 0/C). In contrast, the irradiated ground pork microflora was mainly Gram-positive (66%) shortly after irradiation and increased to 97% after 9 days at 5/sup 0/C. A total of 720 isolates were identified to genus.

  18. [Effects of 25 Gy gamma-ray irradiation on the expression of CD62p in manually enriched human platelets].

    Science.gov (United States)

    Zhao, Lin-Na; Zhao, Hong-Sheng; Li, Jian-Bin; Shan, Hong; Han, Xiao-Gai; Jiao, Hong-Liang

    2010-04-01

    This study was purposed to investigate the effects of 25 Gy gamma-ray irradiation on the CD62p expression, platelet count and the mean platelet volume (MPV) of manually enriched platelet suspension in different time of shelf life at 22 degrees C. Each of 16 bags with plasma-rich platelet was divided into two bags, one of which was exposed to 25 Gy gamma-ray of 137Cs and the other ones was not exposed. 16 bags then were preserved for 72 hours according to AABB standards. The irradiated platelets were regarded as the observation group, and the other ones were regarded as the control group, the expression of p-selectin (CD62p) in the above 2 groups was detected by flow cytometry before irradiation and at 24, 72 hours after irradiation respectively; at the same time, the platelet count and MPV were assayed by using blood cell counter. The results showed that the expression level of CD62p on platelet in irradiated and control groups increased along with the prolonging of preservation time, the expression rate of CD62p on the platelets preserved for 24 hours was higher than that on fresh platelets with significant difference (pplatelets preserved for 72 hours obviously was enhanced as compared with platelets preserved for 24 hours (pplatelet count and MPV between irradiated and control groups preserved for 24 and 72 hours (p>0.05), however the MPV of irradiated and control groups preserved for 72 hours was higher than that of fresh platelets (pquality of platelets, but the preservation time for manually enriched platelet suspension should be shortened as far as possible.

  19. The case for a generic phytosanitary irradiation dose of 400 Gy for Lepidoptera that infest shipped commodities as pupae.

    Science.gov (United States)

    Hallman, Guy J; Parker, Andrew C; Blackburn, Carl M

    2013-04-01

    The pros and cons of a generic phytosanitary irradiation dose against all Lepidoptera pupae on all commodities are discussed. The measure of efficacy is to prevent the F1 generation from hatching (F1 egg hatch) when late pupae are irradiated. More data exist for this measure than for others studied, and it is also commercially tenable (i.e., prevention of adult emergence would require a high dose not tolerated by fresh commodities). The dose required to prevent F1 egg hatch provides a liberal margin of security for various reasons. A point at issue is that correctly irradiated adults could be capable of flight and thus be found in survey traps in importing countries resulting in costly and unnecessary regulatory action. However, this possibility would be rare and should not be a barrier to the adoption of this generic treatment. The literature was thoroughly examined and only studies that could reasonably satisfy criteria of acceptable irradiation and evaluation methodology, proper age of pupae, and adequate presentation of raw data were accepted. Based on studies with 34 species in nine families, we suggest an efficacious dose of 400 Gy. However, large-scale confirmatory testing (> or = 30,000 individuals) has only been reported for one species. A dose as low as 350 Gy might suffice if results of more large-scale studies were available or the measure of efficacy were extended beyond prevention of F1 egg hatch, but data to defend measures of efficacy beyond F1 egg hatch are scarce and more would need to be generated.

  20. Radiotherapy Doses of 80 Gy and Higher Are Associated With Lower Mortality in Men With Gleason Score 8 to 10 Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pahlajani, Niraj [Department of Radiation Oncology, Cooper University Hospital, Camden, NJ (United States); Ruth, Karen J. [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA (United States); Buyyounouski, Mark K. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Chen, David Y.T. [Department of Urology, Fox Chase Cancer Center, Philadelphia, PA (United States); Horwitz, Eric M.; Hanks, Gerald E.; Price, Robert A. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Pollack, Alan, E-mail: apollack@med.miami.edu [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL (United States)

    2012-04-01

    Purpose: Men with Gleason score (GS) 8-10 prostate cancer (PCa) are assumed to have a high risk of micrometastatic disease at presentation. However, local failure is also a major problem. We sought to establish the importance of more aggressive local radiotherapy (RT) to {>=}80 Gy. Methods and Materials: There were 226 men treated consecutively with RT {+-} ADT from 1988 to 2002 for GS 8-10 PCa. Conventional, three-dimensional conformal or intensity-modulated (IM) RT was used. Radiation dose was divided into three groups: (1) <75 Gy (n = 50); (2) 75-79.9 Gy (n = 60); or (3) {>=}80 Gy (n = 116). The endpoints examined included biochemical failure (BF; nadir + 2 definition), distant metastasis (DM), cause-specific mortality, and overall mortality (OM). Results: Median follow-up was 66, 71, and 58 months for Groups 1, 2, and 3. On Fine and Gray's competing risk regression analysis, significant predictors of reduced BF were RT dose {>=}80 Gy (p = 0.011) and androgen deprivation therapy duration {>=}24 months (p = 0.033). In a similar model of DM, only RT dose {>=}80 Gy was significant (p = 0.007). On Cox regression analysis, significant predictors of reduced OM were RT dose {>=}80 Gy (p = 0.035) and T category (T3/4 vs. T1, p = 0.041). Dose was not a significant determinant of cause-specific mortality. Results for RT dose were similar in a model with RT dose and ADT duration as continuous variables. Conclusion: The results indicate that RT dose escalation to {>=}80 Gy is associated with lower risks of BF, DM, and OM in men with GS 8-10 PCa, independently of androgen deprivation therapy.

  1. Treosulfan, Fludarabine and 2 Gy Total Body Irradiation Followed by Allogeneic Hematopoietic Cell Transplantation in Patients with MDS and AML

    Science.gov (United States)

    Gyurkocza, Boglarka; Gutman, Jonathan; Nemecek, Eneida R.; Bar, Merav; Milano, Filippo; Ramakrishnan, Aravind; Scott, Bart; Fang, Min; Wood, Brent; Pagel, John M.; Baumgart, Joachim; Delaney, Colleen; Maziarz, Richard T.; Sandmaier, Brenda M.; Estey, Elihu H.; Appelbaum, Frederick R.; Storer, Barry E.; Deeg, H. Joachim

    2014-01-01

    Allogeneic hematopoietic cell transplantation (HCT) offers curative therapy for many patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). However, post-HCT relapse remains a major problem, particularly in patients with high-risk cytogenetics. In this prospective phase II trial we assessed the efficacy and toxicity of treosulfan, fludarabine and 2 Gy total body irradiation (TBI) as conditioning for allogeneic HCT in patients with MDS or AML. Ninety-six patients with MDS (n=36; 15 RMCD; 10 RAEB-1; 10 RAEB-2; 1 CMML-1) or AML (n=60; 35 CR1; 18 CR2; 3 advanced CR; 4 refractory relapse) were enrolled; median age was 51 (range: 1–60) years. Twelve patients had undergone a prior HCT with high intensity conditioning. Patients received intravenous (IV) treosulfan, 14 g/m2/day on days −6 to −4, IV fludarabine, 30 mg/m2/day on days −6 to −2, and 2 Gy TBI on day 0, followed by infusion of hematopoietic cells from related (n=27) or unrelated (n=69) donors. Graft-vs.-host disease prophylaxis consisted of tacrolimus and methotrexate. With a median follow-up of 30 months, the 2-year overall survival (OS), relapse incidence and non-relapse mortality were 73%, 27% and 8%, respectively. The incidences of grades II–IV (III–IV) acute and chronic graft-versus-host disease were 59% (10%) and 47%, respectively. Two-year OS was not significantly different between MDS patients with poor risk and good/intermediate risk cytogenetics (69% and 85%, respectively), or between AML patients with unfavorable and favorable/intermediate risk cytogenetics (64% and 76%, respectively). In AML patients, minimal residual disease (MRD; n=10) at the time of HCT predicted higher relapse incidence (70% vs. 18%) and lower OS (41% vs. 79%) at 2 years, when compared to patients without MRD. In conclusion, treosulfan, fludarabine and low-dose TBI provided effective conditioning for allogeneic HCT in patients with MDS or AML, and resulted in low relapse incidence, regardless

  2. Fast Fourier Transform IR Characterization of Epoxy GY Systems Crosslinked with Aliphatic and Cycloaliphatic EH Polyamine Adducts

    Directory of Open Access Journals (Sweden)

    Caslav Lacnjevac

    2010-01-01

    Full Text Available The use of fast FT-IR spectroscopy as a sensitive method to estimate a change of the crosslinking kinetics of epoxy resin with polyamine adducts is described in this study. A new epoxy formulation based on the use of polyamine adducts as the hardeners was analyzed. Crosslinking reactions of the different stoichiometric mixtures of the unmodified GY250 epoxy resin with the aliphatic EH606 and the cycloaliphatic EH637 polyamine adducts were studied using mid FT-IR spectroscopic techniques. As the crosslinking proceeded, the primary amine groups in polyamine adduct are converted to secondary and the tertiary amines. The decrease in the IR band intensity of epoxy groups at about 915 cm-1, as well as at about 3,056 cm-1, was observed due to process. Mid IR spectral analysis was used to calculate the content of the epoxy groups as a function of crosslinking time and the crosslinking degree of resin. The amount of all the epoxy species was estimated from IR spectra to changes during the crosslinking kinetics of epichlorhydrin.

  3. Language and Family Dispersion: North Korean Linguist Kim Su-gyŏng and the Korean War

    Directory of Open Access Journals (Sweden)

    Ryuta Itagaki

    2017-03-01

    Full Text Available This article analyzes the unpublished memoir of Kim Su-gyŏng (1918–2000, a linguist who was active in North Korea from the mid-1940s until the late 1960s, and situates his account of his experience of the Korean War within the context of his linguistic essays and correspondence. In doing so, the article considers the role that the personal and the social play in language, utilizing Saussure’s theoretical framework, with which Kim himself was well versed. Kim wrote his memoirs in the 1990s to his family, from whom he had become separated during the Korean War and who now lived in Toronto. In this text, he writes in “personal” language that reveals his uncertainty and his feelings for his family, but then immediately negates these feelings through the use of “social” language, which resonates with his interpretation of the linguistic thesis that Josef Stalin developed during the Korean War on language and national identity. For Kim, the relationship between language and nation was not at all self-evident, but something that he idealized in response to the dispersal of his family. By offering a reflexive reading of a memoir written by a North Korean linguist, this article makes a breakthrough in the investigation of North Korean wartime academic history, which has not risen above the level of analyzing articles in the field of linguistics that were published at the time.

  4. Fast Fourier Transform IR Characterization of Epoxy GY Systems Crosslinked with Aliphatic and Cycloaliphatic EH Polyamine Adducts

    Science.gov (United States)

    Nikolic, Goran; Zlatkovic, Sasa; Cakic, Milorad; Cakic, Suzana; Lacnjevac, Caslav; Rajic, Zoran

    2010-01-01

    The use of fast FT-IR spectroscopy as a sensitive method to estimate a change of the crosslinking kinetics of epoxy resin with polyamine adducts is described in this study. A new epoxy formulation based on the use of polyamine adducts as the hardeners was analyzed. Crosslinking reactions of the different stoichiometric mixtures of the unmodified GY250 epoxy resin with the aliphatic EH606 and the cycloaliphatic EH637 polyamine adducts were studied using mid FT-IR spectroscopic techniques. As the crosslinking proceeded, the primary amine groups in polyamine adduct are converted to secondary and the tertiary amines. The decrease in the IR band intensity of epoxy groups at about 915 cm−1, as well as at about 3,056 cm−1, was observed due to process. Mid IR spectral analysis was used to calculate the content of the epoxy groups as a function of crosslinking time and the crosslinking degree of resin. The amount of all the epoxy species was estimated from IR spectra to changes during the crosslinking kinetics of epichlorhydrin. PMID:22315562

  5. Multidose Stereotactic Radiosurgery (9 Gy × 3) of the Postoperative Resection Cavity for Treatment of Large Brain Metastases

    Energy Technology Data Exchange (ETDEWEB)

    Minniti, Giuseppe, E-mail: gminniti@ospedalesantandrea.it [Radiation Oncology Unit, Sant' Andrea Hospital, University “Sapienza,” Rome (Italy); Department of Neurological Sciences, Scientific Institute IRCCS Neuromed, Pozzilli (Italy); Esposito, Vincenzo [Department of Neurological Sciences, Scientific Institute IRCCS Neuromed, Pozzilli (Italy); Clarke, Enrico; Scaringi, Claudia [Radiation Oncology Unit, Sant' Andrea Hospital, University “Sapienza,” Rome (Italy); Lanzetta, Gaetano [Department of Neurological Sciences, Scientific Institute IRCCS Neuromed, Pozzilli (Italy); Salvati, Maurizio [Department of Neurological Sciences, Scientific Institute IRCCS Neuromed, Pozzilli (Italy); Neurosurgery Unit, Umberto I Hospital, University “Sapienza,” Rome (Italy); Raco, Antonino [Neurosurgery Unit, Sant' Andrea Hospital, University “Sapienza,” Rome (Italy); Bozzao, Alessandro [Neuroradiology Unit, Sant' Andrea Hospital, University “Sapienza,” Rome (Italy); Maurizi Enrici, Riccardo [Radiation Oncology Unit, Sant' Andrea Hospital, University “Sapienza,” Rome (Italy)

    2013-07-15

    Purpose: To evaluate the clinical outcomes with linear accelerator-based multidose stereotactic radiosurgery (SRS) to large postoperative resection cavities in patients with large brain metastases. Methods and Materials: Between March 2005 to May 2012, 101 patients with a single brain metastasis were treated with surgery and multidose SRS (9 Gy × 3) for large resection cavities (>3 cm). The target volume was the resection cavity with the inclusion of a 2-mm margin. The median cavity volume was 17.5 cm{sup 3} (range, 12.6-35.7 cm{sup 3}). The primary endpoint was local control. Secondary endpoints were survival and distant failure rates, cause of death, performance measurements, and toxicity of treatment. Results: With a median follow-up of 16 months (range, 6-44 months), the 1-year and 2-year actuarial survival rates were 69% and 34%, respectively. The 1-year and 2-year local control rates were 93% and 84%, with respective incidences of new distant brain metastases of 50% and 66%. Local control was similar for radiosensitive (non-small cell lung cancer and breast cancer) and radioresistant (melanoma and renal cell cancer) brain metastases. On multivariate Cox analysis stable extracranial disease, breast cancer histology, and Karnofsky performance status >70 were associated with significant survival benefit. Brain radionecrosis occurred in 9 patients (9%), being symptomatic in 5 patients (5%). Conclusions: Adjuvant multidose SRS to resection cavity represents an effective treatment option that achieves excellent local control and defers the use of whole-brain radiation therapy in selected patients with large brain metastases.

  6. p38 MAPK Inhibitor Insufficiently Attenuates HSC Senescence Administered Long-Term after 6 Gy Total Body Irradiation in Mice

    Directory of Open Access Journals (Sweden)

    Lu Lu

    2016-06-01

    Full Text Available Senescent hematopoietic stem cells (HSCs accumulate with age and exposure to stress, such as total-body irradiation (TBI, which may cause long-term myelosuppression in the clinic. However, the methods available for long-term myelosuppression remain limited. Previous studies have demonstrated that sustained p38 mitogen-activated protein kinases (p38 MAPK activation in HSCs following exposure to TBI in mice and the administration of its inhibitor twenty-four hours after TBI may partially prevent long-term myelosuppression. However, long-term myelosuppression is latent and identified long after the administration of radiation. In this study, we investigated the effects of SB203580 (a small molecule inhibitor of p38 MAPK on long-term myelosuppression induced by TBI. Mice with hematopoietic injury were injected intraperitoneally with SB203580 every other day five times beginning 70 days after 6 Gy of 137Cs γ ray TBI. Our results at 80 days demonstrated that SB203580 did not significantly improve the TBI-induced long-term reduction of peripheral blood cell and bone marrow nucleated cell (BMNC counts, or defects in hematopoietic progenitor cells (HPCs and HSC clonogenic function. SB203580 reduced reactive oxygen species (ROS production and p-p38 expression; however, SB203580 had no effect on p16 expression in the HSCs of mice. In conclusion, these findings suggest that treatment with SB203580 70 days after TBI in mice inhibits the ROS-p38 oxidative stress pathway; however, it has no therapeutic effect on long-term myelosuppression induced by TBI.

  7. Long-term results in three-dimensional conformal radiotherapy of localized prostate cancer at moderate dose (66 Gy)

    Energy Technology Data Exchange (ETDEWEB)

    Goldner, G.; Wachter, S.; Wachter-Gerstner, N.; Dieckmann, K.; Poetter, R. [Dept. of Radiotherapy and Radiobiology, Univ. of Vienna, Medical School, Vienna (Austria)

    2006-09-15

    Purpose: biochemical control (bNED), disease-specific survival (DSS), overall survival (OS), and late gastrointestinal (GI) and urogenital (UG) side effects (EORTC/RTOG) of patients with long-term follow-up were evaluated. Patients and methods: three-dimensional radiotherapy up to 66 Gy with/without additional hormonal therapy was performed in 154 prostate cancer (T1-3 NO MO) patients. According to T-stage, pretreatment prostate-specific antigen (PSA) and grading, patients were divided into a low-, intermediate-, and high-risk group. The 5-, 8-, and 10-year actuarial rates of bNED, DSS and OS and late side effects were calculated. Results: median follow-up was 80 months. Additional hormonal therapy was given in 57% of patients. Distribution concerning risk groups (low, intermediate, high) showed 15%, 49%, and 36% of patients, respectively. bNED 5-, 8-, and 10-year actuarial rates were 46%, 44%, and 44%. DSS 5-, 8- and 10-year rates amounted to 96%, 90%, and 82%. OS 5-, 8- and 10-year rates were 81%, 64%, and 56%. In uni- and multivariate analysis, only pretreatment PSA (< 10 vs. {>=} 10 ng/ml; p < 0.05) and PSA nadir (< 0.5 vs. {>=} 0.5 ng/ml; p < 0.0001) affected bNED significantly. Age, risk group, T-stage, grading, and hormonal therapy had no significant influence on bNED, DSS, and OS. Rates of late GI and UG side effects grade {>=} 2 at 5 years were 17% and 15%. Conclusion: current dose escalation studies with better bNED rates may be able to further increase long-term clinical outcome. (orig.)

  8. eGY Education and Outreach: Creating a Virtual Educational Space that Pushes the Envelope for Connecting Teachers and Students to Data

    Science.gov (United States)

    Cobabe-Ammann, E.; Hardin, J.; Fox, P.

    2005-12-01

    The eGY Education and Outreach Program is developing an education portal that connects teachers around the world, in a well-defined way, to the virtual observatories and their data. Using Sakai as the course management platform and drawing on the OCW model, as well as content development models adapted from TERC's Earth Exploration Toolkit, the programming at the eGY portal would allow teachers to use the virtual observatories and its data in an educational context, with supporting materials and activities. Topics included in the eGY portal range from climate change to ocean sciences to the Sun-Earth connection to global seismology, with an emphasis on the intellectual themes that are the focus of other I*Y efforts. In addition, and perhaps as important, the portal will support virtual educational communities, both synchronously and asynchronously. The site will also support virtual seminars (on both science content and educational practices), multimedia assets for teachers, scientific talks, computer-based animations and interactives. Lastly, the eGY program also works with a variety of virtual observatories and other distributed data systems to develop a deeper understanding of the needs of the non-specialist users. The hallmark of the eGY educational program is the implementation of virtual teachers workshops for training high-school and junior college teachers around the world in the use of the portal and its assets. During 2007, as a lead into the eGY, a series of teacher workshops would be run in a virtual environment to an estimated 3000* teachers in over 20 countries. we anticipate that 50 pairs of master teachers in North America will be connected, point-to-point, to 150 to 200 international classrooms of teachers for the workshop. *Currently, in countries that have expressed interest in the program, requests for allotted teacher spots exceed expectation by an order of magnitude and this number is likely to increase.

  9. Vaimueliidi lapsed / Julius Ürt

    Index Scriptorium Estoniae

    Ürt, Julius

    2004-01-01

    Arvustus: Ehin, Kristiina. Luigeluulinn : luuletused. Tallinn : Huma, 2003; [Kaevats, Mihkel] Olematu, Olev. Ederlezi: [luuletused.Tallinn] : Huma, 2003; Viiding, Elo. Teatud erandid : [luuletused]. Tallinn : Tuum, 2003

  10. 2200-IJBCS-Article-Julius Ghogomu

    African Journals Online (AJOL)

    hp

    out at 25 °C in batch mode to evaluate the effects of parameters such as pH, initial phenol concentration and ... model proves that pore diffusion plays little or no significant role in the adsorption of phenol onto .... adsorbents (%R), which is the ratio between ... concentration of phenol, V(L) is the volume of ..... surface area.

  11. 1046-IJBCS-Article-Tieguhong Chupezi Julius

    African Journals Online (AJOL)

    hp

    are coefficients whose values and signs determine the influence of variables on the preference for housing material. P α .... linked to the number of houses constructed. However, the .... ethnicity, gender, household size and number .... Logging companies exploited the five ..... the effects of gender, age, main occupation.

  12. Hyperfractionated Accelerated Radiation Therapy (HART) of 70.6 Gy With Concurrent 5-FU/Mitomycin C Is Superior to HART of 77.6 Gy Alone in Locally Advanced Head and Neck Cancer: Long-term Results of the ARO 95-06 Randomized Phase III Trial

    Energy Technology Data Exchange (ETDEWEB)

    Budach, Volker, E-mail: volker.budach@charite.de [Department of Radiation Oncology, Charité Universitätsmedizin Berlin (Germany); Stromberger, Carmen [Department of Radiation Oncology, Charité Universitätsmedizin Berlin (Germany); Poettgen, Christoph [Department of Radiation Oncology, University Hospital of Essen (Germany); Baumann, Michael [Department of Radiation Oncology, University Hospital of Dresden (Germany); Budach, Wilfried [Department of Radiation Oncology, Heinrich Heine Universität Düsseldorf (Germany); Grabenbauer, Gerhard [Department of Radiation Oncology, University Hospitals of Erlangen (Germany); Marnitz, Simone [Department of Radiation Oncology, Charité Universitätsmedizin Berlin (Germany); Olze, Heidi [Department of Head and Neck Surgery, Charité Universitätsmedizin Berlin (Germany); Wernecke, Klaus-Dieter [Sostana GmbH, Berlin (Germany); Ghadjar, Pirus [Department of Radiation Oncology, Charité Universitätsmedizin Berlin (Germany)

    2015-04-01

    Purpose: To report the long-term results of the ARO 95-06 randomized trial comparing hyperfractionated accelerated chemoradiation with mitomycin C/5-fluorouracil (C-HART) with hyperfractionated accelerated radiation therapy (HART) alone in locally advanced head and neck cancer. Patients and Methods: The primary endpoint was locoregional control (LRC). Three hundred eighty-four patients with stage III (6%) and IV (94%) oropharyngeal (59.4%), hypopharyngeal (32.3%), and oral cavity (8.3%) cancer were randomly assigned to 30 Gy/2 Gy daily followed by twice-daily 1.4 Gy to a total of 70.6 Gy concurrently with mitomycin C/5-FU (C-HART) or 16 Gy/2 Gy daily followed by twice-daily 1.4 Gy to a total dose of 77.6 Gy alone (HART). Statistical analyses were done with the log-rank test and univariate and multivariate Cox regression analyses. Results: The median follow-up time was 8.7 years (95% confidence interval [CI]: 7.8-9.7 years). At 10 years, the LRC rates were 38.0% (C-HART) versus 26.0% (HART, P=.002). The cancer-specific survival and overall survival rates were 39% and 10% (C-HART) versus 30.0% and 9% (HART, P=.042 and P=.049), respectively. According to multivariate Cox regression analysis, the combined treatment was associated with improved LRC (hazard ratio [HR]: 0.6 [95% CI: 0.5-0.8; P=.002]). The association between combined treatment arm and increased LRC appeared to be limited to oropharyngeal cancer (P=.003) as compared with hypopharyngeal or oral cavity cancer (P=.264). Conclusions: C-HART remains superior to HART in terms of LRC. However, this effect may be limited to oropharyngeal cancer patients.

  13. Preoperative irradiation with 5x5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection

    NARCIS (Netherlands)

    Karliczek, A.; Zeebregts, C. J.; Benaron, D. A.; Coppes, R. P.; Wiggers, T.; van Dam, G. M.

    2008-01-01

    Introduction There are conflicting studies on the influence of fractionated preoperative 5 days of 5 Gy irradiation on tissue oxygenation and subsequent colonic anastomotic strength. To elucidate the effect of preoperative irradiation on anastomotic strength, an isolated colon loop model was develop

  14. Muusikamaailm. Magnus Lindbergi festivali jätk. Jonas Forsell taas ooperijuhiks. Marcello Panni uus ooper. György Kurtagile Sonningi preemia. Peter Gradenwitz lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Soome helilooja Magnus Lindbergi mitmeid teoseid esitatakse Inglismaal. Rootsi heliloojast Jonas Forsellist sai jaanuaris Kopenhaageni trupi Den Anden Opera kunstiline juht. Firenzes tuli esiettekandele Marcello Panni uus ooper "The Banquet ئ Talking about Love". Helilooja György Kurtag pälvis Taani 2003.a. Leonie Sonningi muusikapreemia. 91aastasena suri muusikateadlane Peter Gradenwitz

  15. Muusikamaailm. Magnus Lindbergi festivali jätk. Jonas Forsell taas ooperijuhiks. Marcello Panni uus ooper. György Kurtagile Sonningi preemia. Peter Gradenwitz lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Soome helilooja Magnus Lindbergi mitmeid teoseid esitatakse Inglismaal. Rootsi heliloojast Jonas Forsellist sai jaanuaris Kopenhaageni trupi Den Anden Opera kunstiline juht. Firenzes tuli esiettekandele Marcello Panni uus ooper "The Banquet ئ Talking about Love". Helilooja György Kurtag pälvis Taani 2003.a. Leonie Sonningi muusikapreemia. 91aastasena suri muusikateadlane Peter Gradenwitz

  16. An Upper and Lower Solution Theory for the Problem (G'(y))' + f(t,y) = 0 on Finite and Infinite Intervals

    Institute of Scientific and Technical Information of China (English)

    Ravi P. AGARWAL; Donal O'REGAN; Svatoslav STAN(E)K

    2006-01-01

    A new upper and lower solution theory is presented for the second order problem (G'(y))' + f(t,y) = 0 on finite and infinite intervals. The theory on finite intervals is based on a Leray-Schauder alternative, whereas the theory on infinite intervals is based on results on the finite interval and a diagonalization process.

  17. 3-D conformal treatment of prostate cancer to 74 Gy vs. high-dose-rate brachytherapy boost: A cross-sectional quality-of-life survey

    Energy Technology Data Exchange (ETDEWEB)

    Vordermark, Dirk [Univ. of Wuerzburg (DE). Dept. of Radiation Oncology] (and others)

    2006-09-15

    The effects of two modalities of dose-escalated radiotherapy on health-related quality of life (HRQOL) were compared. Forty-one consecutive patients were treated with a 3-D conformal (3-DC) boost to 74 Gy, and 43 with high-dose rate (HDR) brachytherapy boost (2x9 Gy), following 3-D conformal treatment to 46 Gy. Median age was 70 years in both groups, median initial PSA was 7.9 {mu}g/l in 3-DC boost patients and 8.1 {mu}g/l in HDR boost patients. Stage was 7 in 52% and 47%, respectively. HRQOL was assessed cross-sectionally using EORTC QLQ-C30 and organ-specific PR25 modules 3-32 (median 19) and 4-25 (median 14) months after treatment, respectively. Questionnaires were completed by 93% and 97% of patients, respectively. Diarrhea and insomnia scores were significantly increased in both groups. In the PR25 module, scores of 3-DC boost and HDR boost patients for urinary, bowel and treatment-related symptoms were similar. Among responders, 34% of 3-DC boost patients and 86% of HDR boost patients had severe erectile problems. Dose escalation in prostate cancer by either 3-DC boost to 74 Gy or HDR brachytherapy boost appears to result in similar HRQOL profiles.

  18. Whole-brain radiotherapy with 20 Gy in 5 fractions for brain metastases in patients with cancer of unknown primary (CUP)

    Energy Technology Data Exchange (ETDEWEB)

    Rades, D. [Dept. of Radiation Oncology, Univ. Hospital Schleswig-Holstein, Luebeck (Germany); Dept. of Radiation Oncology, Univ. Hospital Hamburg-Eppendorf, Hamburg (Germany); Bohlen, G.; Dunst, J. [Dept. of Radiation Oncology, Univ. Hospital Schleswig-Holstein, Luebeck (Germany); Lohynska, R. [Dept. of Radiation Oncology, Univ. Hospital Prague (Czech Republic); Veninga, T. [Dept. of Radiotherapy, Dr. Bernard Verbeeten Inst., Tilburg (Netherlands); Stalpers, L.J.A. [Dept. of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Schild, S.E. [Dept. of Radiation Oncology, Mayo Clinic Scottsdale, AZ (United States)

    2007-11-15

    Background: Whole brain radiotherapy (WBRT) is the most common treatment for brain metastases. Survival of patients with cancer of unknown primary (CUP) presenting with brain metastases is extremely poor. A radiation program with a short overall treatment time (short-course RT) would be preferable to longer programs if it provides similar outcomes. This study compares short-course RT with 20 Gy in 5 fractions (5 x 4 Gy) given over 5 days to longer programs in CUP patients. Patients and Methods: Data regarding 101 CUP patients who received either short course WBRT (n = 34) with 5 x 4 Gy or long-course WBRT (n = 67) with 10 x 3 Gy given over 2 weeks or 20 x 2 Gy given over 4 weeks for brain metastases were analyzed retrospectively. Six additional potential prognostic factors were investigated: age, gender, Karnofsky performance score (KPS), number of brain metastases, extracranial metastases, RPA-(Recursive Partitioning Analysis-)class. Results: On univariate analysis, the radiation program was not associated with survival (p = 0.88) nor intracerebral control (p = 0.36). Improved survival was associated with KPS {>=} 70 (p < 0.001), absence of extracranial metastases (p < 0.001), and RPA-class 1 (p < 0.001). On multivariate analyses, KPS (risk ratio [RR]: 4.55; p < 0.001), extracranial metastases (RR: 1.70; p = 0.018), and RPA-class (RR: 2.86; p < 0.001) maintained significance. On univariate analysis, KPS (p < 0.001) and RPA-class (p < 0.001) were significantly associated with intracerebral control. On multivariate analyses, KPS (RR: 2.72; p < 0.001) and RPA-class (RR: 2.09; p < 0.001) remained significant. Conclusion: Short-course WBRT with 5 x 4 Gy provided similar intracerebral control and survival as longer programs for the treatment of brain metastases in CUP patients. 5 x 4 Gy appears preferable because it is more convenient for patients. (orig.)

  19. Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy.

    Science.gov (United States)

    Dunlap, Neal E; Cai, Jing; Biedermann, Gregory B; Yang, Wensha; Benedict, Stanley H; Sheng, Ke; Schefter, Tracey E; Kavanagh, Brian D; Larner, James M

    2010-03-01

    To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy. From a combined, larger multi-institution experience, 60 consecutive patients treated with three to five fractions of stereotactic body radiotherapy for primary or metastatic peripheral lung lesions were reviewed. CW pain was assessed using the Common Toxicity Criteria for pain. Peripheral lung lesions were defined as those located within 2.5 cm of the CW. A minimal point dose of 20 Gy to the CW was required. The CW volume receiving >or=20, >or=30, >or=40, >or=50, and >or=60 Gy was determined and related to the risk of CW toxicity. Of the 60 patients, 17 experienced Grade 3 CW pain and five rib fractures. The median interval to the onset of severe pain and/or fracture was 7.1 months. The risk of CW toxicity was fitted to the median effective concentration dose-response model. The CW volume receiving 30 Gy best predicted the risk of severe CW pain and/or rib fracture (R(2) = 0.9552). A volume threshold of 30 cm(3) was observed before severe pain and/or rib fracture was reported. A 30% risk of developing severe CW toxicity correlated with a CW volume of 35 cm(3) receiving 30 Gy. The development of CW toxicity is clinically relevant, and the CW should be considered an organ at risk in treatment planning. The CW volume receiving 30 Gy in three to five fractions should be limited to <30 cm(3), if possible, to reduce the risk of toxicity without compromising tumor coverage. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  20. Biochemical response after 3-D conformal radiotherapy of localized prostate cancer to a total dose of 66 Gy. 4 year results

    Energy Technology Data Exchange (ETDEWEB)

    Wachter-Gerstner, N.; Wachter, S.; Goldner, G.; Nechvile, E.; Poetter, R. [Universitaetsklinik fuer Strahlentherapie und Strahlenbiologie, AKH Wien (Austria)

    2002-10-01

    Background: Since the introduction of 3-D conformal radiotherapy (CRT) doses of {<=}70 Gy have been used in many European countries. In this analysis, the impact of a short-term neoadjuvant hormonal treatment in combination with CRT to a moderate dose level of 66 Gy was examined. Patients and methods: From January 1994 to February 1999 397 patients were treated for carcinoma of the prostate. In 279 patients a definitive curative treatment (T1=38, T2=165, T3=50, Tx=11) with or without androgen deprivation was performed. 164 patients with radiotherapy of the prostate{+-}seminal vesicles to a total dose of 66 Gy (n=109) alone or in combination with a short-term hormonal treatment (n=55) were included in this analysis. Biochemical relapse was defined as three rising PSA values or reintroduction of hormonal treatment. A low-risk subgroup was defined for patients with maximum serum PSA level {<=}10 and ct{<=}2 and G{<=}2, all other patients were summarized as high-risk patients. Results: The median follow-up of alive patients was 40 months (12-72 months). There was a total of 29/164 deaths, two were cause-specific and 27 were considered unrelated to prostate cancer. The 4-year rates of no biochemical evidence of disease for all patients was 58%. For the high-risk group the 4-year rates could be improved with borderline significance from 35% to 66% (p=0.057) by additional neoadjuvant hormonal treatment. In contrast for the low-risk group no significant improvement was observed: 73% and 82%, respectively (p=0.5). Conclusion: Especially in high-risk patients doses <70 Gy for radiotherapy alone seem not to be sufficient for curative treatment. Additional hormonal treatment and doses >70 Gy should be considered. As a consequence of our earlier analysis a prospective multicenter treatment optimization protocol has been initiated in 1999. The protocol includes a risk-adapted dose increase from 70 Gy in low-risk patients to 74 Gy in high-risk patients including short

  1. Absence of the A4 peptide in the G4 glycinin subunit of soybean cultivar Enrei is caused by a point mutation in the Gy4 gene

    Directory of Open Access Journals (Sweden)

    Yu Kangfu

    2005-01-01

    Full Text Available Functional properties of soy proteins for food are closely related to the composition of their storage protein subunits. Using base excision sequence scanning (BESS, we show that the absence of the A4 peptide in the G4 glycinin subunit of the soybean (Glycine max L. cultivar Enrei was caused by the same point mutation in the Gy4 gene as previously reported in the soybean cultivar Raiden. Although the genetic relationship between Raiden and Enrei is not known, the same point mutation in their Gy4 genes may indicate that they probably share a related origin. The application of BESS to identify single nucleotide polymorphisms (SNPs as co-dominant markers for marker-assisted selection (MAS of a recessive null allele is also discussed.

  2. [The effect of mixed cultivation of lymphocytes irradiated at a dose of 1 Gy and non-irradiated lymphocytes on the frequency of chromosomal aberration].

    Science.gov (United States)

    Kolesnikova, I S

    2012-01-01

    The mutual influence of irradiated (1 Gy) and non-irradiated cells was demonstrated on the model of the mixed culture oflymphocytes from opposite gender donors using chromosome aberrations (ChA) as an endpoint. The number of ChA in non-irradiated lymphocytes in mixed cultures with irradiated ones increased as compared to the corresponding monocultures. At the same time, the number of induced ChA decreased in the irradiated lymphocytes cultivated with non-irradiated ones.

  3. 浅析采用ITG3205+ADXL345+HMC5883L芯片的GY-85九轴IMU传感器在headtracker中的运用

    Institute of Scientific and Technical Information of China (English)

    闫珩亮

    2015-01-01

    传感器的应用越来越广泛,而采用ITG3205+ADXL345+ HMC5883L芯片的GY-85九轴IMU传感器是刚刚研发而来的,本文就这一新型传感器进行解说,并将其具体运用到headtracker中来。

  4. Accelerated radiotherapy with concomitant boost technique (69.5 Gy/5 weeks). An alternative in the treatment of locally advanced head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kubes, Jiri; Vondracek, Vladimir; Pala, Miloslav [Prague Univ., Prag (Czech Republic). Inst. of Radiation Oncology; Cvek, Jakub; Feltl, David [Faculty Hospital Ostrava (Czech Republic). Dept. of Oncology

    2011-10-15

    To present the feasibility and results of accelerated radiotherapy with concomitant boost technique (69.5 Gy/5 weeks) in the treatment of locally advanced head and neck cancer. A total of 65 patients were treated between June 2006 and August 2009. The distribution of clinical stages was as follows: II 11%, III 23%, IV 61%, and not defined 5%. The median follow-up was 30.5 months. The treatment plan was completed in 94% of patients. Patients were treated using the conformal or intensity-modulated radiotherapy (IMRT) technique. The median overall treatment time was 37 days (13-45 days). The mean radiotherapy dose was 68.4 Gy (16-74 Gy). Overall survival was 69% after 2 years. Disease-free survival was 62% after 2 years. Acute toxicity {>=} grade 3(RTOG scale) included mucositis (grade 3: 42.6%), pharynx (grade 3: 42.3%), skin (grade 3: 9.5%), larynx (grade 3: 4%), while late toxicity affected skin (grade 3: 6.25%) and salivary glands (grade 3: 3.7%). Accelerated radiotherapy with concomitant boost technique is feasible in patients with locally advanced head and neck cancer, has an acceptable toxicity profile, and yields promising treatment results.

  5. The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.

    Science.gov (United States)

    Homma, Kazuaki; Duan, Chongwen; Zheng, Jing; Cheatham, Mary Ann; Dallos, Peter

    2013-01-25

    Outer hair cells (OHCs) are a mammalian innovation for mechanically amplifying sound energy to overcome the viscous damping of the cochlear partition. Although the voltage-dependent OHC membrane motor, prestin, has been demonstrated to be essential for mammalian cochlear amplification, the molecular mechanism by which prestin converts electrical energy into mechanical displacement/force remains elusive. Identifying mutations that alter the motor function of prestin provides vital information for unraveling the energy transduction mechanism of prestin. We show that the V499G/Y501H mutation does not deprive prestin of its voltage-induced motor activity, but it does significantly impair the fast motor kinetics and voltage operating range. Furthermore, mutagenesis studies suggest that Val-499 is the primary site responsible for these changes. We also show that V499G/Y501H prestin forms heteromers with wild-type prestin and that the fast motor kinetics of wild-type prestin is not affected by heteromer formation with V499G/Y501H prestin. These results suggest that prestin subunits are individually functional within a given multimer.

  6. Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

    2011-04-18

    We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

  7. Assessment of The Dose-Response Relationship of Radiation-Induced Bystander Effect in Two Cell Lines Exposed to High Doses of Ionizing Radiation (6 and 8 Gy).

    Science.gov (United States)

    Bahreyni Toossi, Mohammad Taghi; Khademi, Sara; Azimian, Hosein; Mohebbi, Shokoufeh; Soleymanifard, Shokouhozaman

    2017-10-01

    The dose-response relationship of radiation-induced bystander effect (RIBE) is controversial at high dose levels. The aim of the present study is to assess RIBE at high dose levels by examination of different endpoints. This experimental study used the medium transfer technique to induce RIBE. The cells were divided into two main groups: QU-DB cells which received medium from autologous irradiated cells and MRC5 cells which received medium from irradiated QU-DB cells. Colony, MTT, and micronucleus assays were performed to quantify bystander responses. The medium was diluted and transferred to bystander cells to investigate whether medium dilution could revive the RIBE response that disappeared at a high dose. The RIBE level in QU-DB bystander cells increased in the dose range of 0.5 to 4 Gy, but decreased at 6 and 8 Gy. The Micronucleated cells per 1000 binucleated cells (MNBN) frequency of QU-DB bystander cells which received the most diluted medium from 6 and 8 Gy QU-DB irradiated cells reached the maximum level compared to the MNBN frequency of the cells that received complete medium (Pbystander cells. This finding confirmed that a negative feedback mechanism was responsible for the decrease in RIBE response at high doses. Decrease of RIBE at high doses might be used to predict that in radiosurgery, brachytherapy and grid therapy, in which high dose per fraction is applied, normal tissue damage owing to RIBE may decrease.

  8. Differential effects of 18- and 24-Gy cranial irradiation on growth rate and growth hormone release in children with prolonged survival after acute lymphocytic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Cicognani, A.; Cacciari, E.; Vecchi, V.; Cau, M.; Balsamo, A.; Pirazzoli, P.; Tosi, M.T.; Rosito, P.; Paolucci, G.

    1988-11-01

    To evaluate the effects of two different doses of cranial irradiation on growth and growth hormone (GH) release, we studied 61 children with acute lymphocytic leukemia who had survived at least five years in continuous complete remission. Forty-three children received 24 Gy (group 1) and 18 children received 18 Gy (group 2). Height was evaluated at diagnosis, at the end of treatment, and 6, 12, and 24 months later. Growth hormone release was evaluated by arginine and levodopa tests after the end of treatment. After diagnosis, the height SD score decreased significantly in both groups; two years after the end of treatment, only group 1 showed an SD score for height that was still significantly lower than at diagnosis. Group 1 showed impaired GH responses to the tests and, compared with controls, group 1 in fact included a percentage of subjects with a normal response to levodopa (ie, greater than 8 micrograms/L) that was significantly lower (56.4% vs 83.3%) and a percentage of nonresponders to both tests that was significantly higher (21.6% vs 0%). These data indicate that only patients treated with lower cranial irradiation dosage (18 Gy) had complete growth recovery and normal GH responses to pharmacologic tests.

  9. Effects of 0.075 Gy x-ray irradiation on the expression of IL-10 and IL-12 in mice

    Science.gov (United States)

    Liu, Xiao-Dong; Ma, Shu-Mei; Liu, Shu-Zheng

    2003-07-01

    The objective was to observe the effects of 0.075 Gy low dose radiation (LDR) on the synthesis of IL-10 in splenocytes and the secretion of IL-12 by peritoneal macrophages. Kunming mice were selected and randomly grouped. Northern blot and flow cytometry were adopted to detect the changes of IL-10 at mRNA and protein levels, respectively. Northern blot and ELISA were used, respectively, to examine the changes of IL-12 p35/p40 mRNA and IL-12 p70 protein levels. IL-10 mRNA decreased significantly in splenocytes, while both IL-12 p35 and p40 subunit mRNA levels in macrophages increased after whole body irradiation (WBI) with 0.075 Gy x-rays. Meanwhile, IL-10 synthesis in splenocytes decreased beginning from 4 h after exposure and remaining at a lower level up to 48 h, and IL-12 secretion by macrophages was found to take the opposite direction, i.e. increase significantly. In conclusion, WBI with 0.075 Gy x-rays may suppress IL-10 both at the mRNA level and protein level and stimulate IL-12 expression simultaneously, which might contribute to a shift of the immune response in favour of Th1 differentiation.

  10. Substantiation of 25 kGy radiation sterilization dose for banked air dried amniotic membrane and evaluation of personnel skill in influencing finished product bioburden.

    Science.gov (United States)

    Marsit, Nagi; Dwejen, Samira; Saad, Ibrahim; Abdalla, Sedigh; Shaab, Arej; Salem, Salma; Khanfas, Enas; Hasan, Anas; Mansur, Mohamed; Abdul Sammad, Mohamed

    2014-12-01

    Preparation of amniotic membrane (AM) by air drying method followed by radiation sterilization is simple and valuable approach; sterility and quality of the final AM product are depending on the quality management system at the tissue bank. Validation and substantiation of radiation sterilization dose (RSD) for tissue allografts is an essential step for the development and validation of the standard operating procedures (SOP). Application of SOP is perfectly relying on trained staff. Skills differences among personnel involved in AM preparation could have an effect on microbiological quality of the finished product and subsequently on the RSD required. AM were processed by four different couples of the tissue bank technicians. The AM grafts were randomly selected and subjected to bioburden test to validate and substantiate the 25 kGy RSD. Bioburden test for AM grafts were also useful to evaluate the skill of the tissue bank technicians and thus, to validate the current SOP for air dried AM. Moreover, the effect of placental source on bioburden counts on AM grafts was assessed. Substantiation of the 25 kGy RSD at a sterility assurance level of 10(-1), and sample item portion = 1, was carried out using Method VD max (25) of the International Organization for Standardization, document no. 11137-2 (ISO in Sterilization of healthcare products-radiation-part 2: establishing the sterilization dose, Method VDmax-substantiation of 25 kGy or 15 kGy as the sterilization dose, International Standard Organization, 2006). The results showed that there were no significant differences in the bioburdens of the four batches (α = 1 %), this means no significant differences in the skill of the four couples of the tissue bank technicians in terms of their ability to process AM according to the air dried AM SOP. The 25 kGy RSD was validated and substantiated as a valid sterilization dose for the AM prepared with the current established SOP at the Biotechnology Research Center

  11. Survival fraction and phenotype alterations of Xenopus laevis embryos at 3 Gy, 150 kV X-ray irradiation.

    Science.gov (United States)

    Carotenuto, Rosa; Tussellino, Margherita; Mettivier, Giovanni; Russo, Paolo

    2016-11-25

    To determine the radiosensitivity of Xenopus laevis embryos, aquatic organism model, for toxicity studies utilizing X-rays at acute high dose levels, by analysing its survival fraction and phenotype alterations under one-exposure integral dose. We used the standard Frog Embryo Teratogenesis Assay Xenopus test during the early stages of X. laevis development. The embryos were harvested until st. 46 when they were irradiated. The radiation effects were checked daily for a week and the survival, malformations and growth inhibition were assessed. Sibling tadpoles as control organisms were used. Statistical analysis was performed to assess the extent of any damage. Irradiation was performed with an X-ray tube operated at 150 kV. The tube containing the tadpoles was exposed to an air kerma of 3 Gy as measured in air with an in-beam ionization chamber. After one week, survival fraction of irradiated embryos was 58%, while for control embryos it was 81%. Hence, irradiation with 150 kV, 3 Gy X-rays produced a 23% decrease of survival in regard to unirradiated embryos. The 70% of the irradiated embryos showed an altered distribution of the skin pigmentation, in particular on the dorsal area and in the olfactory pits, where the pigment concentration increased by a factor 2. In conclusion exposure of X. laevis to 3 Gy, 150 kV X-rays induced a reduction of embryos survival and a significant modification of pigmentation. The authors think that X. laevis embryos, at st 46, is a suitable biological model for large scale investigations on the effects of ionizing radiation.

  12. Implant R100 Predicts Rectal Bleeding in Prostate Cancer Patients Treated with IG-IMRT to 45 Gy and Pd-103 Implant

    Directory of Open Access Journals (Sweden)

    Matthew Packard

    2014-01-01

    Full Text Available Purpose. To define factors associated with rectal bleeding in patients treated with IG-IMRT followed by Pd-103 seed implant. Methods and Materials. We retrospectively reviewed 61 prostate adenocarcinoma patients from 2002 to 2008. The majority (85.2% were of NCCN intermediate risk category. All received IG-IMRT to the prostate and seminal vesicles followed by Pd-103 implant delivering a mean D90 of 100.7 Gy. Six patients received 45 Gy to the pelvic nodes and 10 received androgen deprivation. Results. Ten patients (16.4% developed rectal bleeding: 4 were CTCAE v.3 grade 1, 5 were grade 2, and 1 was grade 3. By univariate analysis, age, stage, Gleason sum, PSA, hormonal therapy, pelvic radiation, postoperative prostate volume, D9, V100, individual source activity, total implanted activity per cm3, and duration of interval before implant did not impact rectal bleeding. Implant R100 was higher in patients with rectal bleeding: on average, 0.885 versus 0.396 cm3, P=.02, odds ratio of 2.26 per .5 cm3 (95% CI, 1.16–4.82. A trend for significance was seen for prostate V200 and total implanted activity. Conclusion. Higher implant R100 was associated with development of rectal bleeding in patients receiving IG-IMRT to 45 Gy followed by Pd-103 implant. Minimizing implant R100 may reduce the rate of rectal bleeding in similar patients.

  13. Experiences about the integrated fruit and grape cultivation target programme in the micro-region of Gyöngyös

    Directory of Open Access Journals (Sweden)

    Cecília Gonda

    2011-11-01

    Full Text Available The most popular target programme of the agricultural-environmental programme advertised by the New Hungary Rural Development Programme in the period between 2010-2014 was the integrated fruit and grape cultivation target programme in the micro-region of Gyöngyös. In the course of our research we were curious how the farms were prepared for it (professional knowledge, technology etc. whether they were able to adapt to the rules and at the same time how it could take effect on the financial positions of the farms.

  14. Muestreo de minerales: análisis de sensibilidad y factores de corrección para la ecuación de Pierre Gy

    Directory of Open Access Journals (Sweden)

    Vallebuona, G.

    2005-02-01

    Full Text Available Pierre Gy's equation is widely used in ore sampling. This equation is based in four parameters: shape factor, size distribution factor, mineralogical factor and liberation factor. The usual practice is to consider fixed values for the shape and size distribution factors. This practice does not represent well several important ores. The mineralogical factor considers only one specie of interest and the gangue, leaving out other cases such as polymetalic ores where there are more than one specie of interest. A sensibility analysis to the Gy's equation factors was done and a procedure to determine specific values for them was developed and presented in this work. Mean ore characteristics, associated with an insecure use of the actual procedure, were determined. Finally, for a case study, the effects of using each alternative were evaluated.

    La ecuación de Pierre Gy es la más utilizada en el muestreo de minerales. Esta ecuación está basada en cuatro parámetros: factor de forma, factor de granulometría, factor de mineralogía y factor de liberación. La práctica usual es considerar valores fijos para los factores de forma y granulometría, dejando fuera a una gama importante de minerales que no son bien representados por dichos valores. Con respecto al factor de mineralogía, se consideran, solamente, una especie mineralógica de interés y la ganga, no considerando otros casos, como los minerales polimetálicos donde hay más de una especie de interés. En este trabajo se sensibilizó la ecuación de Gy con respecto a sus factores y se han desarrollado algunos procedimientos para determinar valores específicos para éstos. Se han determinado las características principales de los minerales asociadas con un uso inseguro del procedimiento utilizado actualmente. Finalmente, para un caso en estudio, se evaluó el efecto de utilizar una u otra alternativa.

  15. Alanine-EPR dosimetry for measurements of ionizing radiation absorbed doses in the range 0.5-10 kGy

    CERN Document Server

    Peimel-Stuglik, Z

    2001-01-01

    The usefulness of two, easy accessible alanine dosimeters (ALANPOL from IChTJ and foil dosimeter from Gamma Service, Radeberg, Germany) to radiation dose measurement in the range of 0.5-10 kGy, were investigated. In both cases, the result of the test was positive. The foil dosemeter from Gamma Service is recommended for dose distribution measurements in fantoms or products, ALANPOL - for routine measurements. The EPR-alanine method based on the described dosimeters can be successfully used, among others, in the technology of radiation protection of food.

  16. Early FDG PET at 10 or 20 Gy under chemoradiotherapy is prognostic for locoregional control and overall survival in patients with head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hentschel, Maria [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Clinic and Polyclinic of Nuclear Medicine, Dresden (Germany); Appold, Steffen; Baumann, Michael [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Clinic and Polyclinic of Radiotherapy and Radiation Oncology, Dresden (Germany); Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, OncoRay, National Center for Radiation Research in Oncology Dresden, Dresden (Germany); Schreiber, Andreas [Hospital Dresden-Friedrichstadt, Department of Radiotherapy, Dresden (Germany); Abolmaali, Nasreddin [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, OncoRay, National Center for Radiation Research in Oncology Dresden, Dresden (Germany); Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Institute and Polyclinic of Diagnostic Radiology, Dresden (Germany); Abramyuk, Andrij [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, OncoRay, National Center for Radiation Research in Oncology Dresden, Dresden (Germany); Doerr, Wolfgang [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Clinic and Polyclinic of Radiotherapy and Radiation Oncology, Dresden (Germany); Kotzerke, Joerg; Zoephel, Klaus [Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Clinic and Polyclinic of Nuclear Medicine, Dresden (Germany); Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, OncoRay, National Center for Radiation Research in Oncology Dresden, Dresden (Germany)

    2011-07-15

    Our study aimed to explore the optimal timing as well as the most appropriate prognostic parameter of {sup 18}F-fluorodeoxyglucose positron emission tomography (FDG PET) during chemoradiotherapy (CRT) for an early prediction of outcome for patients with head and neck squamous cell carcinoma (HNSCC). Serial PET data (before and three times during CRT) of 37 patients with advanced stage HNSCC, receiving combined CRT between 2005 and 2009, were evaluated. The maximum standardized uptake value (SUV{sub max}), the average SUV (SUV{sub mean}) and the gross tumour volume determined by FDG PET (GTV PET), based on a source to background algorithm, were analysed. Stratified actuarial analysis was performed for overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). The median follow-up time was 26 months (range 8-50). For all patients, OS was 51%, DFS 44% and LRC 55% after 2 years. The 2-year OS (88%) and 2-year LRC (88%) were higher for patients whose SUV{sub max} of the primary tumour decreased 50% or more from the beginning (0 Gy) to week 1 or 2 (10 or 20 Gy) of CRT ({delta}SUV{sub max10/20} {>=} 50%) than for patients with {delta}SUV{sub max20} < 50% (2-year OS = 38%; p = 0.02; 2-year LRC 40%; p = 0.06). A pretreatment GTV PET below the median of 10.2 ml predicted a better 2-year OS (34% for GTV PET {>=} 10.2 ml vs 83% for GTV PET < 10.2 ml; p = 0.02). The decrease of SUV{sub max} from before (0 Gy) to week 1 or 2 (10 or 20 Gy) of CRT is a potential prognostic marker for patients with HNSCC. Because GTV PET depends on the applied method of analysis, we suggest the use of SUV{sub max}, especially {delta}SUV{sub max10/20}, for an early estimation of therapy outcome. Confirmatory studies are warranted. (orig.)

  17. Haematological effects of rhGM-CSF in dogs exposed to total-body irradiation with a dose of 2. 4 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Nothdurft, W.; Selig, C.; Fliedner, T.M.; Kreja, L.; Weinsheimer, W. (Ulm Univ. (Germany)); Hintz-Obertreis, P.; Krumwieh, D.; Kurrle, R.; Seiler, F.R. (Ulm Univ. (Germany). Inst. of Occupational and Social Medicine)

    1992-04-01

    It was the aim of this study to test the stimulatory effects of recombinant human GM-CSF (rhGM-CSF) on haemopoietic regeneration in dogs which had received total-body irradiation (TBI) with a dose of 2.4 Gy. Results indicate that treatment with GM-CSF can be an effective biological monotherapy for radiation-induced bone marrow failure, but that for higher radiation doses the number of GM-CSF responsive target cells will become a critical determinant of therapeutic efficacy. (author).

  18. Thermoluminescence of Ge- and Al-Doped SiO2 Optical Fibers Subjected to 0.2-4.0 Gy External Photon Radiotherapeutic Dose

    Science.gov (United States)

    Hossain, I.; Wagiran, H.; Yaakob, N. H.

    2013-09-01

    In this work, we studied the thermoluminescence response of Ge- and Al-doped optical fibers, its linearity, energy dependence, and sensitivity. The Ge-doped optical fibers demonstrate useful TL properties and represent an excellent candidate for use in TL dosimetry of ionizing radiation. The TL response increases monotonically over a wide photon dose range, from 0.2 Gy to 4.0 Gy. The TL results for these fibers have been compared with similar TL data for phosphor TLD-100. Commercially available Al- and Ge-doped optical fibers have both been found to yield a linear dose-TL signal relationship, although the Al-doped fiber provides only 5 % of the sensitivity of the Ge-doped fibers. The TL characteristics of Ge-doped optical fiber, plus its small size (125 μm diameter), high flexibility, ease of handling, and low cost compared with other TL materials, make this commercial optical fiber a very promising TL material for use in medicine, industry, reactor operation, and a variety of other areas.

  19. Thyroxine clearance in rats within the first month after the single whole-body {gamma} - irradiation at a dose of 10Gy

    Energy Technology Data Exchange (ETDEWEB)

    Pryadko, Kirill A. [Institute of Radiobiology, National Academy of Sciences, Minsk (Belarus)

    2002-07-01

    The effects of acute whole-body {gamma} -irradiation at a dose of 10 Gy on thyroxine (T{sub 4}) plasma clearance rate (PCR) and thyroidal and blood T4 concentration ([T{sub 4}]) were examined within one month after exposure. The PCR values were measured using the bolus injection, single-compartmental approach. To eliminate the influence of radiation-induced anorexia animals were fasting for two days before the pharmacokinetic experiments. Hormone concentrations in blood and in thyroid tissue were measured by RIA. Throughout the observation period, PCR was elevated in irradiated rats with maximum at day 4 after exposure (0.56{+-}0.04 vs. 0.36{+-}0.03 ml/h100 gbw, P<0.001). [T{sub 4}] in blood was not significantly different from that in control animals. Thyroidal [T{sub 4}] was significantly decreased in irradiated animals 4 days after exposure (151.8{+-}21.7 vs. 258.8{+-}29.9 pmol/mg protein, P<0.01) and gradually increased after day 9. 10 Gy {gamma} -irradiation causes the intensification of T{sub 4} metabolism without the pronounced changes in concentration. Presumably, at early terms the rising local demand in O{sub 4} can not be compensated with the existing level of production. Alterations in the intensity of T{sub 4} metabolism are evident at least one month after exposure but they may not be detected without taking into account kinetic data.

  20. SAFETY AND TOXICITY OF AN ACCELERATED COARSELY FRACTIONATED RADIATION PROTOCOL FOR TREATMENT OF APPENDICULAR OSTEOSARCOMA IN 14 DOGS: 10 GY × 2 FRACTIONS.

    Science.gov (United States)

    Pagano, Candace; Boudreaux, Bonnie; Shiomitsu, Keijiro

    2016-09-01

    Coarsely fractionated radiation is commonly used as a method for pain control in dogs with appendicular osteosarcoma, however there is little published information on optimal protocols. The aim of this retrospective, descriptive study was to report safety and toxicity findings in a sample of dogs with appendicular osteosarcoma that had been treated with a radiation scheme of 10 Gy delivered over two consecutive days for a total of 20 Gy. Dogs were included in the study if they had osteosarcoma that was treated with the aforementioned protocol. Dogs were excluded if treated with the same protocol for any other bone tumor besides osteosarcoma or inadequate follow-up. Thirteen of the 14 patients received adjuvant therapy with pamidronate and a nonsteroidal anti-inflammatory. Nine dogs received adjuvant chemotherapy with carboplatin after radiation was complete. Within a median of 14 days, 92.8% of dogs subjectively had improved pain control. Median duration of response (DOR) was 80 days (range 20-365). The majority of patients developed VRTOG grade one toxicity, primarily alopecia. Five dogs (35.7%) developed pathologic fracture postradiation treatment. Timing of fracture was variable ranging from 24 to 250 days. This radiation protocol was well tolerated, with minimal toxicity, subjectively improved survival time, and had the benefit of being completed in two consecutive days. © 2016 American College of Veterinary Radiology.

  1. Calibration Curve for Dicentric Chromosomes Induced in Human Blood Lymphocytes Exposed to Gamma Rays at a Dose Rate of 12.5 mGy/s.

    Science.gov (United States)

    Que, Tran; Duy, Pham Ngoc; Luyen, Bui Thi Kim

    2016-01-01

    To develop a calibration curve for induction of dicentric chromosomes by radiation, we have used a 60Co gamma-ray source with dose rate of 12.5 mGy/s. Whole blood from 15 healthy donors was collected. Whole blood from each donor was divided equally into 8 parts for exposing to supposedly physical doses 0, 0.30, 0.50, 1.00, 1.50, 2.00, 3.00 and 4.00 Gy for a independent calibration curve. Whole blood from 15 donors was used to calibrate dose - effect and statistical for general calibration curve. Using Poisson test (U-test) for the distribution of dicentric chromosomes in the metaphases to determine the uniformity of the radiation field. The average from 15 independent calibration curves of linear correlated coefficient was determined to be r (y, d) = 0.5136 ± 0.0038. The model equation derived is y = aD + bD(2) + C. The calibration equation of dose-effect was y = 1.01D + 4.43D(2) + 0.56.

  2. Study of L-aspartic acid for its possible use as a dosimeter in the interval of 3.4-20 kGy at different irradiation temperatures

    Science.gov (United States)

    Meléndez-López, Adriana; Negrón-Mendoza, Alicia; Gómez-Vidales, Virginia; Uribe, Roberto M.; Ramos-Bernal, Sergio

    2014-11-01

    Certain commercial applications of radiation processing increase the efficiency of chemical reactions at low temperatures to decrease the free radicals in the bulk material and avoid the synergistic effects of heat. Such applications have motivated the search for a reliable, low-temperature dosimeter for use under the conditions of the irradiation process. For this purpose, polycrystalline samples of L-aspartic acid (2-aminobutanedioic acid) were irradiated with gamma rays at low temperatures and doses in the kiloGray range (3.4-64 kGy). The potential use of the aspartic acid system as a chemical dosimeter is based on the formation of stable free radicals when the amino acid is exposed to ionizing radiation. These radicals can be studied and quantified using electron spin resonance (ESR). The response curves at different temperatures show that the intensity of the ESR spectra (the five characteristic lines) depends on the dose received. The response of the dosimeter increases with increasing temperature, and this relationship is linear up to 20 kGy at 298 K. The decay characteristics show that the change in the ESR signal over time is low and reproducible. In addition, the L-aspartic acid dosimeter is easy to handle and has low cost.

  3. Protective effects of Quercetin to 6 Gy irradiated rats%槲皮素对X射线照射后大鼠免疫功能的影响

    Institute of Scientific and Technical Information of China (English)

    崔亚利; 赵红光; 焦明秀; 林承赫

    2008-01-01

    Objective To evaluate the radioprotective effects of Quercetin (QN) on 6 Gy X-ray irradiation-induced immune dysfunction and toxicity in hepatic tissue in rats. Methods 40 adult rats were randomly divided into 4 groups. Group Ⅰ was injected intraperitoneally with saline solution for 7 consecutive day sand served as control group. Group Ⅱ was daily injected with QN (40 mg/kg) for 7 consecutive days. Group Ⅲ was irradiated with a single dose of 6 Gy X-ray. Group Ⅳ received a daily injection of QN (40 mg/kg) for 7 consecutive days, and 1 h after the last injection rats were irradiated with a single dose (6 Gy) X-ray irradiation.The animals were sacrificed after 24 h. Lymphocyte transforming rate was measured with MTT method, and CD+4 T, CD+4 T and CD+8/CD+8 T were measured with flow cytometry method. Oxidative conditions in liver were measured with malondialdehyde (MDA), reduced glutathione hormone (GSH), supernxide dismutase (SOD) andglutathione peroxidase (GSH-Px) activities kits. HE staining was used to observe the general condition of rat's liver. Results Lymphocyte transforming rate, CD+4 T, CD+8 T and CD+8/CD+8 T in rats of Group Ⅳ were all higher than those in rats of Group Ⅲ ( F = 8.455,22.644, 18.911, P < 0.01 ). MDA content in the Group Ⅳ rat's liver was lower than that in the Group Ⅲ ( F = 10.059, P < 0.01 ) and antioxidant enzymes SOD, GSH-Px activities were higher than those in Group Ⅲ (F = 23.688,186.046,19.788, P < 0.01 ). The capillary of the hepatic lobules dilated and congested obviously in portal area, involving infiltration of polymorphonuclear leukocytes in the Group Ⅲ, while QN improved this change apparendy. Conclusions Pretreatment with Quercetin improved the irradiated rat's immune functions and protected the irradiated rats from oxidative stress to some extent.%目的 探讨槲皮素(ON)对6 Gy X射线照射后大鼠免疫功能及肝脏氧化应激反应的影响.方法 40只大鼠随机分成4组,每组10只,第1

  4. Use of the gamma radiation, in a dose of 0,4 kGy, on the storage temperature reduction of the banana nanica;Utilizacao da radiacao gama, na dose de 0,4kGy, na reducao da temperatura de armazenamento da banana nanica

    Energy Technology Data Exchange (ETDEWEB)

    Manoel, Luciana, E-mail: luciana_manoel@yahoo.com.b [Universidade Estadual Paulisa (UNESP), Botucatu, SP (Brazil). Fac. de Ciencias Agronomicas. Programa de Pos-graduacao em Energia na Agricultura; Vieites, Rogerio Lopes, E-mail: vieites@fca.unesp.b [Universidade Estadual Paulisa (UNESP), Botucatu, SP (Brazil). Fac. de Ciencias Agronomicas. Dept. de Gestao e Tecnologia Agroindustrial

    2009-07-01

    The aim was to evaluate the use of gamma radiation, in a dose of 0,4 kGy, on the storage temperature reduction of the banana 'Nanica'. The bananas 'Nanica' were harvested in the Arm Taperao, Brotas (SP) town, and sent to CBE (Companhia Brasileira de Esterilizacao-Cotia-SP) for irradiation and constitution of the following treatments: T1 (fruits irradiated at 0,4 kGy and stored at 16 +-1 deg C); T2 (fruits irradiated at 0,4 kGy and stored at 14 +-1 deg C); T3 (fruit irradiated ata 0,4 kGy and stored at 12+-1 deg C); T4 (fruits non-irradiated and stored at 16+-1 deg C); T5 (fruits non-irradiated and stored at 14+-1 deg C) and T6 (fruits non-irradiated and stored at 12+-1 deg C). The fruits were stored in B.O.Ds. of the Agroindustrial Management and Technology Department, with a relative humidity of 80+-5%. The experiment was divided in two groups: control group (post harvest conservation and disease incidence) and parcel group (soluble solids and pulp/peel). The analyses were performed in intervals of five days during a period of 25 days. The experimental design employed was completely randomized (DIC) by applying a factor of 2 x 3 x 6 (irradiation x temperature x time). The Tukey test with 5% of probability was used for comparison between means. The storage temperature of the bananas 'Nanica' was not reduce by irradiation. (author)

  5. Concerto para violino de György Ligeti: sua relevância enquanto obra representativa do estilo tardio “Não-Atonal” do compositor

    OpenAIRE

    Ivan Paula Santos Machado Dantas; Alexandre Roberto Lunsqui

    2015-01-01

    O presente trabalho busca discutir a importância do Concerto para Violino de György Ligeti e sua relevância dentre as obras do estilo tardio do compositor. Para isso são apontadas as principais características da música de Ligeti em suas diversas fases, desde sua música textural em peças como “Atmosphères” até seu recente “Hamburg Concerto”, e as peculiaridades do que o próprio Ligeti chama de estilo “não-atonal”. Uma análise do Concerto permite, então, criar relações com as características e...

  6. Marguerite Duras/Claude Régy: L’Amante Anglaise, the genesis of a text, the gestation of a theatre

    Directory of Open Access Journals (Sweden)

    Almuth Grésillon

    2013-07-01

    Full Text Available This article focuses on the genesis of the first staging of Margerite Duras’s L’Amante Anglaise, by Claude Régy, a well succeeded genesis, carried out based on the interplay between dramaturgy and the stage. Without any satisfying answer, we are facing an important theoretical issue of genetic criticism applied to theatre: is the work a dramatic text or a spectacle? Depending on the stress on the first or on the second answer, the organizing axis of the genetic dossier can be the author’s writing and all stagings of L’Amante Anglaise,forming a theoretically unified set; or the director’s notes and all of his creations. This study explores a third possibility, stipulating the indispensable intersection between both hypotheses.

  7. Inactivation of contaminated fungi and antioxidant effects of peach (Prunus persica L. Batsch cv Dangeumdo) by 0.5-2 kGy gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung-Hee; Kim, Mi-Seon [Department of Food and Nutrition, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Kim, Hong-Gi [Department of Applied Biology, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Yook, Hong-Sun, E-mail: yhsuny@naver.co [Department of Food and Nutrition, Chungnam National University, Daejeon 305-764 (Korea, Republic of)

    2010-04-15

    The effect of gamma irradiation (0.5-2 kGy) on the physicochemical properties of peaches was investigated during a 6-day storage at 20+-3 deg. C. Gamma irradiation is able to inactivate the four pathogens, namely Botrytis cinerea, Penicillium expansum, Rhizopus stolonifer var. stolonifer and Monilinia fructicola in peaches. Hardness significantly decreased with the increment of irradiation dose level whereas soluble solid and total polyphenol contents increased with increment of irradiation dose level. 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity of the irradiated peach was higher than that of control, and its activity increased with increment of irradiation dose level. These results suggest that gamma irradiation of peaches improved antioxidant activity, but dramatically affects the hardness throughout the entire storage time.

  8. A Study of Jet and Missing Transv erse Ener gy Reconstruction and Data Cleaning Techniques on ATLAS Calorimeter Cosmic Ray Data

    CERN Document Server

    Bain, Travis

    Monte Carlo generated QCD jets, and jets reconstructed from cosmic ray data are analyzed and compared. This comparison allo ws some of the rst opportunities to run through a full study , from data collection, to reconstruction, to analysis, within ATLAS, using real events. The ability to handle data at every step of the way will be crucial in achie ving a ìsteady-stateî mode of operation in the coming months and years of ATLAS operation. The use of electromagnetic fractions as a data cleaning technique within the ATLAS calorimeter system is also studied and sho wn to be a rob ust tool in remo ving high ener gy cosmic ray events as a background from jet and E Miss T distributions

  9. Inactivation of contaminated fungi and antioxidant effects of peach ( Prunus persica L. Batsch cv Dangeumdo) by 0.5-2 kGy gamma irradiation

    Science.gov (United States)

    Kim, Kyoung-Hee; Kim, Mi-Seon; Kim, Hong-Gi; Yook, Hong-Sun

    2010-04-01

    The effect of gamma irradiation (0.5-2 kGy) on the physicochemical properties of peaches was investigated during a 6-day storage at 20±3 °C. Gamma irradiation is able to inactivate the four pathogens, namely Botrytis cinerea, Penicillium expansum, Rhizopus stolonifer var. stolonifer and Monilinia fructicola in peaches. Hardness significantly decreased with the increment of irradiation dose level whereas soluble solid and total polyphenol contents increased with increment of irradiation dose level. 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity of the irradiated peach was higher than that of control, and its activity increased with increment of irradiation dose level. These results suggest that gamma irradiation of peaches improved antioxidant activity, but dramatically affects the hardness throughout the entire storage time.

  10. The freezing and thawing of water in poultry meat and vegetables irradiated by electrons at doses of 0.1-4 kGy.

    Science.gov (United States)

    Dubini, B; Ferrante, L; Leonardi, M; Messina, G; Montecchia, F; Ponzi-Bossi, M G

    1993-06-01

    Poultry meat and some vegetables, irradiated by 5 MeV electrons (0.1-4 kGy), were analysed by differential scanning calorimetry, from 24 h after irradiation. The temperature and enthalpy transitions of the water contained in the irradiated samples were measured and compared with those of unirradiated samples. We analysed 18 meat and 10 vegetable samples for each irradiation dose together with a similar number of unirradiated controls. The mean supercooling temperatures of water in the irradiated poultry meat samples and in some vegetables are significantly lower than those of controls. Moreover, the freezing enthalpies of the irradiated poultry breast are significantly lower than those of controls, while they are unchanged in the other cases. The mean ice melting temperatures and enthalpies are similar for all samples. The amount of the lowering of the water-ice transition depends on the nature of the sample and is highest in poultry breast and lowest in vegetables.

  11. Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation.

    Science.gov (United States)

    Lenarczyk, Marek; Su, Jidong; Haworth, Steven T; Komorowski, Richard; Fish, Brian L; Migrino, Raymond Q; Harmann, Leanne; Hopewell, John W; Kronenberg, Amy; Patel, Shailendra; Moulder, John E; Baker, John E

    2015-06-01

    The ability of simvastatin to mitigate the increases in risk factors for and the occurrence of cardiac disease after 10 Gy total body irradiation (TBI) was determined. This radiation dose is relevant to conditioning for stem cell transplantation and threats from radiological terrorism. Male rats received single dose TBI of 10 Gy. Age-matched, sham-irradiated rats served as controls. Lipid profile, heart and liver morphology and cardiac mechanical function were determined for up to 120 days after irradiation. TBI resulted in a sustained increase in total- and LDL-cholesterol (low-density lipoprotein-cholesterol), and triglycerides. Simvastatin (10 mg/kg body weight/day) administered continuously from 9 days after irradiation mitigated TBI-induced increases in total- and LDL-cholesterol and triglycerides, as well as liver injury. TBI resulted in cellular peri-arterial fibrosis, whereas control hearts had less collagen and fibrosis. Simvastatin mitigated these morphological injuries. TBI resulted in cardiac mechanical dysfunction. Simvastatin mitigated cardiac mechanical dysfunction 20-120 days following TBI. To determine whether simvastatin affects the ability of the heart to withstand stress after TBI, injury from myocardial ischemia/reperfusion was determined in vitro. TBI increased the severity of an induced myocardial infarction at 20 and 80 days after irradiation. Simvastatin mitigated the severity of this myocardial infarction at 20 and 80 days following TBI. It is concluded simvastatin mitigated the increases in risk factors for cardiac disease and the extent of cardiac disease following TBI. This statin may be developed as a medical countermeasure for the mitigation of radiation-induced cardiac disease.

  12. Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice.

    Science.gov (United States)

    Wang, Bing; Tanaka, Kaoru; Ji, Bin; Ono, Maiko; Fang, Yaqun; Ninomiya, Yasuharu; Maruyama, Kouichi; Izumi-Nakajima, Nakako; Begum, Nasrin; Higuchi, Makoto; Fujimori, Akira; Uehara, Yoshihiko; Nakajima, Tetsuo; Suhara, Tetsuya; Ono, Tetsuya; Nenoi, Mitsuru

    2014-01-01

    The cause and progression of Alzheimer's disease (AD) are poorly understood. Possible cognitive and behavioral consequences induced by low-dose radiation are important because humans are exposed to ionizing radiation from various sources. Early transcriptional response in murine brain to low-dose X-rays (100 mGy) has been reported, suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and AD. To investigate acute and late transcriptional, pathological and cognitive consequences of low-dose radiation, we applied an acute dose of 100-mGy total body irradiation (TBI) with X-rays to C57BL/6J Jms mice. We collected hippocampi and analyzed expression of 84 AD-related genes. Mouse learning ability and memory were assessed with the Morris water maze test. We performed in vivo PET scans with (11)C-PIB, a radiolabeled ligand for amyloid imaging, to detect fibrillary amyloid beta peptide (Aβ) accumulation, and examined characteristic AD pathologies with immunohistochemical staining of amyloid precursor protein (APP), Aβ, tau and phosphorylated tau (p-tau). mRNA studies showed significant downregulation of only two of 84 AD-related genes, Apbb1 and Lrp1, at 4 h after irradiation, and of only one gene, Il1α, at 1 year after irradiation. Spatial learning ability and memory were not significantly affected at 1 or 2 years after irradiation. No induction of amyloid fibrillogenesis or changes in APP, Aβ, tau, or p-tau expression was detected at 4 months or 2 years after irradiation. TBI induced early or late transcriptional alteration in only a few AD-related genes but did not significantly affect spatial learning, memory or AD-like pathological change in mice.

  13. Low-Dose (10-Gy) Total Skin Electron Beam Therapy for Cutaneous T-Cell Lymphoma: An Open Clinical Study and Pooled Data Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kamstrup, Maria R., E-mail: mkam0004@bbh.regionh.dk [Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen (Denmark); Gniadecki, Robert [Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen (Denmark); Iversen, Lars [Department of Dermatology, Aarhus University Hospital, Aarhus (Denmark); Skov, Lone [Department of Dermatology, Gentofte Hospital, University of Copenhagen, Copenhagen (Denmark); Petersen, Peter Meidahl [Department of Oncology and Hematology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Loft, Annika [Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Specht, Lena [Department of Oncology and Hematology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark)

    2015-05-01

    Purpose: Cutaneous T-cell lymphomas (CTCLs) are dominated by mycosis fungoides (MF) and Sézary syndrome (SS), and durable disease control is a therapeutic challenge. Standard total skin electron beam therapy (TSEBT) is an effective skin-directed therapy, but the possibility of retreatments is limited to 2 to 3 courses in a lifetime due to skin toxicity. This study aimed to determine the clinical effect of low-dose TSEBT in patients with MF and SS. Methods and Materials: In an open clinical study, 21 patients with MF/SS stages IB to IV were treated with low-dose TSEBT over <2.5 weeks, receiving a total dose of 10 Gy in 10 fractions. Data from 10 of these patients were published previously but were included in the current pooled data analysis. Outcome measures were response rate, duration of response, and toxicity. Results: The overall response rate was 95% with a complete cutaneous response or a very good partial response rate (<1% skin involvement with patches or plaques) documented in 57% of the patients. Median duration of overall cutaneous response was 174 days (5.8 months; range: 60-675 days). TSEBT-related acute adverse events (grade 1 or 2) were observed in 60% of patients. Conclusions: Low-dose (10-Gy) TSEBT offers a high overall response rate and is relatively safe. With this approach, reirradiation at times of relapse or progression is likely to be less toxic than standard dose TSEBT. It remains to be established whether adjuvant and combination treatments can prolong the beneficial effects of low-dose TSEBT.

  14. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model

    Energy Technology Data Exchange (ETDEWEB)

    Ossetrova, N.I. [Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States)], E-mail: ossetrova@afrri.usuhs.mil; Farese, A.M.; MacVittie, T.J. [Marlene and Stewart Greenebaum Cancer Center, Bressler Research Building, Room 7-039, University of Maryland-Baltimore, 655 West Baltimore Street, Baltimore, MD 21201 (United States); Manglapus, G.L.; Blakely, W.F. [Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States)

    2007-07-15

    The present need to rapidly identify severely irradiated individuals in mass-casualty and population-monitoring scenarios prompted an evaluation of potential protein biomarkers to provide early diagnostic information after exposure. The level of specific proteins measured using immunodiagnostic technologies may be useful as protein biomarkers to provide early diagnostic information for acute radiation exposures. Herein we present results from on-going studies using a non-human primate (NHP) 6-Gy X-rays ( 0.13Gymin{sup -1}) whole-body radiation model. Protein targets were measured by enzyme-linked immunosorbent assay (ELISA) in blood plasma before, 1, and 2 days after exposure. Exposure of 10 NHPs to 6 Gy resulted in the up-regulation of plasma levels of (a) p21 WAF1/CIP1, (b) interleukin 6 (IL-6), (c) tissue enzyme salivary {alpha}-amylase, and (d) C-reactive protein. Data presented show the potential utility of protein biomarkers selected from distinctly different pathways to detect radiation exposure. A correlation analysis demonstrated strong correlations among different combinations of four candidate radiation-responsive blood protein biomarkers. Data analyzed with use of multivariate discriminant analysis established very successful separation of NHP groups: 100% discrimination power for animals with correct classification for separation between groups before and 1 day after irradiation, and 95% discrimination power for separation between groups before and 2 days after irradiation. These results also demonstrate proof-in-concept that multiple protein biomarkers provide early diagnostic information to the medical community, along with classical biodosimetric methodologies, to effectively manage radiation casualty incidents.

  15. Antifungal Activity of Marine Pseudomonas GY-1 and Purification of the Antifungal Protein%海洋假单胞菌GY-1菌株的抗菌作用及其胞外抗菌蛋白的分离纯化

    Institute of Scientific and Technical Information of China (English)

    王淑芳; 暴增海; 马桂珍; 葛平华; 吴少杰; 付泓润

    2012-01-01

    In the present study,agar-well diffusion method and Oxford Cup method were used to detect the antimicrobial activities of marine Pseudomonas GY-1 strain.The results showed that GY-1 strain and its fermentation broth had relatively strong inhibition activity against a variety of phytopathogenic fungi,including Bipolaris sorokiniana,Fusarium graminearum,Alternaria solania,Alternaria alternate,Sclerotinia sclerotiorum and Alternaria tenuis Nees.Further study had successfully purified a protein from Pseudomonas GY-1 by ammonium sulfate fractional precipitation,DEAE sepharose fast flow ion exchange chromatography and Sephadex G-75 filtration chromatography.This protein showed obvious inhibition activity against B.sorokiniana.SDS-PAGE analysis revealed that the molecular weight of the protein was about 70.9 kD.%采用对峙培养法和牛津杯法测定海洋假单胞杆菌(Pseudomonas)GY-1菌株和发酵液的抑菌作用。结果表明:GY-1菌株和发酵液对小麦根腐病菌(Bipolaris sorokiniana)、禾谷镰刀病菌(Fusarium graminearum)、菠菜早疫病菌(Alternaria solania)、斑点落叶病菌(Alternaria alternata)、油菜菌核病菌(Sclerotinia sclerotiorum)和小麦叶枯病菌(Alternaria tenuis Nees)等植物病原真菌有较强的抑制作用。发酵液采用硫酸铵分级沉淀、DEAE Sepharose Fast Flow柱层析、Sephadex G-75凝胶层析,以小麦根腐病菌为指示菌进行活性追踪和SDS-PAGE电泳纯度跟踪检测,纯化出一种对小麦根腐病菌具有明显抗菌作用的抗菌蛋白,其分子质量约为70.9kD。

  16. 6 Gy 137Cs γ射线照射对小鼠造血功能损伤的动态观察研究%Effects of 6 Gy 137Cs γ-irradiattion on the hematopoietic system of mice

    Institute of Scientific and Technical Information of China (English)

    路璐; 张俊伶; 李德冠; 王月英; 孟爱民

    2015-01-01

    目的 观察6 Gy 137Cs γ射线照射对小鼠造血功能的影响.方法 取雄性C57BL/6小鼠70只,随机分为对照组和照射组,每组35只.照射组小鼠接受6 Gy 137Cs γ射线一次性全身照射,分别于受照后1、3、7、10、14、35和56d测定小鼠体质量,并检测外周血象的变化、外周血网织红细胞百分率和骨髓有核细胞数,在受照后14、35和56 d检测小鼠骨髓细胞粒单系集落形成能力.结果 照射后小鼠体质量下降,14d后缓慢上升;外周血象中WBC和血小板数迅速下降,分别于照射后7和10d下降至最低值,而后缓慢回升;骨髓有核细胞数急剧下降,于照射后7和10d下降至最低值,而后逐渐恢复;外周血网织红细胞百分率经历了下降、恢复、超出正常值范围及恢复至正常值的过程;骨髓有核细胞粒单系集落形成能力显著下降.结论 6 Gy 137Cs γ射线照射可引起小鼠外周血象的变化并抑制造血祖细胞的增殖能力.%Objective To observe the effects of 6 Gy 137Cs γ-irradiation on the hematopoietic system of mice.Methods Seventy male C57BL/6 mice were randomly divided into control and irradiated groups (n=35 each).The irradiation group mice received 6 Gy mCs γ-irradiation.Bodyweight, peripheral blood cell counts, bone marrow mononuclear cell counts, and reticulocyte percentage were measured at 1, 3, 7, 10, 14, 35, and 56 d after total body irradiation.CFU-GM was detected at 14, 35, and 56 d after 6 Gy 137Cs γ-irradiation.Results After irradiation, the bodyweight of irradiated mice decreased but slowly increased after 14 d.The peripheral blood of irradiated mice had significant changes in WBC and platelet counts: it respectively decreased to the lowest value at 7 and 10 d post-irradiation and subsequently increased slowly.The reticulocyte percentage decreased, recovered, exceeded the normal range, and returned to normal.Furthermore, the bone marrow mononuclear cell counts decreased sharply, decreased to the

  17. Concerto para violino de György Ligeti: sua relevância enquanto obra representativa do estilo tardio “Não-Atonal” do compositor

    Directory of Open Access Journals (Sweden)

    Ivan Paula Santos Machado Dantas

    2015-06-01

    Full Text Available O presente trabalho busca discutir a importância do Concerto para Violino de György Ligeti e sua relevância dentre as obras do estilo tardio do compositor. Para isso são apontadas as principais características da música de Ligeti em suas diversas fases, desde sua música textural em peças como “Atmosphères” até seu recente “Hamburg Concerto”, e as peculiaridades do que o próprio Ligeti chama de estilo “não-atonal”. Uma análise do Concerto permite, então, criar relações com as características e singularidades deste estilo tardio, tais quais a utilização de tríades fora de um contexto tonal, uso simultâneo de sistemas de afinação distintos, uso de formas tradicionais como Passacaglia e Hoquetus, e trazer um entendimento mais amplo e contextualizado da obra. A análise divide-se por movimentos do concerto e tenta mostrar aspectos diversos da construção da obra, não se fixando a uma única ferramenta analítica ou teoria. Esta análise do material, da instrumentação e da textura podem servir ao propósito da interpretação da obra.

  18. Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi’s Concept (Szeged till Novel Approaches to Boost Mitochondrial Bioenergetics

    Directory of Open Access Journals (Sweden)

    Levente Szalárdy

    2015-01-01

    Full Text Available Impaired function of certain mitochondrial respiratory complexes has long been linked to the pathogenesis of chronic neurodegenerative disorders such as Parkinson’s and Huntington’s diseases. Furthermore, genetic alterations of mitochondrial genome or nuclear genes encoding proteins playing essential roles in maintaining proper mitochondrial function can lead to the development of severe systemic diseases associated with neurodegeneration and vacuolar myelinopathy. At present, all of these diseases lack effective disease modifying therapy. Following a brief commemoration of Professor Albert Szent-Györgyi, a Nobel Prize laureate who pioneered in the field of cellular respiration, antioxidant processes, and the roles of free radicals in health and disease, the present paper overviews the current knowledge on the involvement of mitochondrial dysfunction in central nervous system diseases associated with neurodegeneration including Parkinson’s and Huntington’s disease as well as mitochondrial encephalopathies. The review puts special focus on the involvement and the potential therapeutic relevance of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α, a nuclear-encoded master regulator of mitochondrial biogenesis and antioxidant responses in these disorders, the transcriptional activation of which may hold novel therapeutic value as a more system-based approach aiming to restore mitochondrial functions in neurodegenerative processes.

  19. Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics.

    Science.gov (United States)

    Szalárdy, Levente; Zádori, Dénes; Klivényi, Péter; Toldi, József; Vécsei, László

    2015-01-01

    Impaired function of certain mitochondrial respiratory complexes has long been linked to the pathogenesis of chronic neurodegenerative disorders such as Parkinson's and Huntington's diseases. Furthermore, genetic alterations of mitochondrial genome or nuclear genes encoding proteins playing essential roles in maintaining proper mitochondrial function can lead to the development of severe systemic diseases associated with neurodegeneration and vacuolar myelinopathy. At present, all of these diseases lack effective disease modifying therapy. Following a brief commemoration of Professor Albert Szent-Györgyi, a Nobel Prize laureate who pioneered in the field of cellular respiration, antioxidant processes, and the roles of free radicals in health and disease, the present paper overviews the current knowledge on the involvement of mitochondrial dysfunction in central nervous system diseases associated with neurodegeneration including Parkinson's and Huntington's disease as well as mitochondrial encephalopathies. The review puts special focus on the involvement and the potential therapeutic relevance of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α), a nuclear-encoded master regulator of mitochondrial biogenesis and antioxidant responses in these disorders, the transcriptional activation of which may hold novel therapeutic value as a more system-based approach aiming to restore mitochondrial functions in neurodegenerative processes.

  20. Tachyzoites of Toxoplasma gondii irradiated with 255 Gy induces decrease of cysts and cerebral lesions in mice challenged with cysts of ME-49; Taquizoitos de Toxoplasma gondii irradiados com 255 Gy induzem diminuicao de cistos e lesoes cerebrais em camundongos desafiados com cistos da cepa ME-49

    Energy Technology Data Exchange (ETDEWEB)

    Hiramoto, Roberto Mitsuyoshi; Galisteo Juniorm Andres Jimenez; Nascimento, Nanci do; Andrade Junior, Heitor Franco de [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Lab. de Biologia Molecular]. E-mail: rmhiramoto@bol.com.br; hfandrad@usp.br

    2002-07-01

    Toxoplasmosis can cause ocular lesions in normal individuals and several diseases in foetus, HIV infection and transplants. Toxoplasma gondii has a complex life cycle, involving cats, as the definitive host, and warm blood species, as intermediated hosts. The infection occurs by ingestion of food and water contaminated with infected cat faeces, contaminated milk and cheese or raw and undercook meat of the intermediated hosts. To date, there is no commercial vaccine of use in humans. In this work, tachyzoites of T. gondii RH strain were irradiated with 255 Gy and inoculated in C57Bl/6j mice (3 doses, biweekly), after mice were challenged with 1, 5, 10, 20 and 25 cysts of ME-49 by oral gavage. The lesions and cysts in the brain were analyzed in all mice, after 4-week post infection. The mortality was 20% in control mice (ME-49 cysts only) and not one in immunized mice. The number of cysts was high in the control group, but low in immunized 255 Gy mice (n<100). Immunized mice showed less cerebral pathology and necrosis foci. Ionizing radiation is an important tool in the study toxoplasmosis and vaccine development. (author)

  1. Effect of sesamol on the hematopoietic system damage in 4 Gy 137 Csγ-Ray irradiated mice%芝麻酚对4Gy137Csγ射线照射小鼠造血功能的影响

    Institute of Scientific and Technical Information of China (English)

    路璐; 李德冠; 张俊伶; 樊赛军; 孟爱民

    2014-01-01

    Objective To observe the effect of sesamol on the hematopoietic system in mice exposed to 4 Gy irradiation. Method Twenty C 57 BL/6 mice were randomly divided into control group, sesamol group, irradiated group and irradiated+sesamol group (n=5). Mice of control and sesamol group received sham irradiation, and the rest exposed to 4 Gy total body irradiation, dose rate 1.01 Gy/min. Mice in sesamol group and irradiated+sesamol group received a dose of 10 mg/kg sesamol administered by gavage every day for 7 days after irradiation exposure. Mice of other two groups were treated with vehicle solution. After 4 Gy irradiation 7 day, the peripheral bloods were collected. The levels of colony forming units-granulocyte-macrophage (CFU-GM) were detected. Results Compared to irradiation group, the level of WBC、cell count of BMNCs and CFU-GM significantly decreased in the irradiated mice, decreased in the irradiated mice (P<0.05). Compared to irradiation group, cell count of BMNCs and CFU-GM in the irradiated+sesamol group increased significantly (P<0.05). Conclusion Sesamol has a certain impact on the radiation-induced changes in hematopoietic system. The mechanism need to be further explored.%目的:探讨芝麻酚对小鼠造血功能辐射损伤的影响。方法取雌性C 57 BL/6小鼠20只,随机分为对照组、芝麻酚组、照射组和照射+芝麻酚组,每组5只。照射组和照射+芝麻酚组小鼠接受4 Gy 137 Csγ射线一次性全身照射。芝麻酚组和照射+芝麻酚组小鼠照射后2 h灌胃芝麻酚(10 mg/kg),连续给药7天,其余2组小鼠灌胃生理盐水。小鼠受照后7 d处死,取外周血进行血象测定,取骨髓细胞测定有核细胞数和集落形成能力。结果照射组与对照组比较,外周血白细胞、骨髓有核细胞数明显下降,粒单系集落形成单位(colony-forming unit-granulocyte/macrophage,CFU-GM)显著下降(P<0.05)。照射+芝麻酚组与照射组相比,骨髓有核细胞数

  2. DART-bid: dose-differentiated accelerated radiation therapy, 1.8 Gy twice daily. High local control in early stage (I/II) non-small-cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zehentmayr, Franz; Wurstbauer, Karl; Deutschmann, Heinz; Sedlmayer, Felix [Landeskrankenhaus Salzburg, Univ.-Klinik fuer Radiotherapie und Radio-Onkologie, Univ.-Klinikum der Paracelsus Medizinischen Privatuniversitaet, Salzburg (Austria); Paracelsus Medizinische Privatuniversitaet, Institute for Research and Development of Advanced Radiation Technologies (radART), Salzburg (Austria); Fussl, Christoph; Kopp, Peter; Dagn, Karin; Fastner, Gerd [Landeskrankenhaus Salzburg, Univ.-Klinik fuer Radiotherapie und Radio-Onkologie, Univ.-Klinikum der Paracelsus Medizinischen Privatuniversitaet, Salzburg (Austria); Porsch, Peter; Studnicka, Michael [Landeskrankenhaus Salzburg, Univ.-Klinik fuer Pneumologie, Univ.-Klinikum der Paracelsus Medizinischen Privatuniversitaet, Salzburg (Austria)

    2014-09-23

    While surgery is considered standard of care for early stage (I/II), non-small-cell lung cancer (NSCLC), radiotherapy is a widely accepted alternative for medically unfit patients or those who refuse surgery. International guidelines recommend several treatment options, comprising stereotactic body radiation therapy (SBRT) for small tumors, conventional radiotherapy ≥ 60 Gy for larger sized especially centrally located lesions or continuous hyperfractionated accelerated RT (CHART). This study presents clinical outcome and toxicity for patients treated with a dose-differentiated accelerated schedule using 1.8 Gy bid (DART-bid). Between April 2002 and December 2010, 54 patients (median age 71 years, median Karnofsky performance score 70 %) were treated for early stage NSCLC. Total doses were applied according to tumor diameter: 73.8 Gy for < 2.5 cm, 79.2 Gy for 2.5-4.5 cm, 84.6 Gy for 4.5-6 cm, 90 Gy for > 6 cm. The median follow-up was 28.5 months (range 2-108 months); actuarial local control (LC) at 2 and 3 years was 88 %, while regional control was 100 %. There were 10 patients (19 %) who died of the tumor, and 18 patients (33 %) died due to cardiovascular or pulmonary causes. A total of 11 patients (20 %) died intercurrently without evidence of progression or treatment-related toxicity at the last follow-up, while 15 patients (28 %) are alive. Acute esophagitis ≤ grade 2 occurred in 7 cases, 2 patients developed grade 2 chronic pulmonary fibrosis. DART-bid yields high LC without significant toxicity. For centrally located and/or large (> 5 cm) early stage tumors, where SBRT is not feasible, this method might serve as radiotherapeutic alternative to present treatment recommendations, with the need of confirmation in larger cohorts. (orig.) [German] Die Standardbehandlung fuer nichtkleinzellige Bronchialkarzinome (NSCLC) im Stadium I/II ist die Operation, wobei Radiotherapie fuer Patienten, die nicht operabel sind oder die Operation ablehnen, als Alternative

  3. DNA-flow cytometry of defined stages of rat seminiferous epithelium: Effects of 3 Gy of high-energy X-irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kangasniemi, M.; Veromaa, T.; Kulmala, J.; Kaipia, A.; Parvinen, M.; Toppari, J. (Univ. of Turku (Finland))

    1990-05-01

    Testes of adult Sprague-Dawley rats were irradiated locally by 3 Gy of 4 MeV X-rays produced by a linear accelerator. This type and dose of radiation gives an even distribution through the testis and selectively kills the proliferating spermatogonia. The seminiferous tubular cells were quantified by DNA flow cytometry at defined stages of the epithelial cycle at 7, 17, 22, 38, 52, and 80 days after irradiation. The flow cytometric technique was modified by using frozen instead of fresh samples. Freezing did not alter cell numbers when compared with fresh samples. At 7 days post-irradiation no significant changes were observed in any cell population by DNA flow cytometry, whereas histological analysis revealed a reduction in intermediate and type B spermatogonia. At 17 and 22 days post-irradiation, the number of cells at meiotic prophase (4C) was decreased, particularly in stages II-V of the cycle. In stages VII-VIII, cell numbers were 40 and 31%, and in stages IX-XIII, 24 and 43% of that in non-irradiated controls at 17 and 22 days, respectively. At 38 days after irradiation, both 4C and 1C (haploid) cells were decreased in number. The 4C cells were reduced to 24, 17, and 13% of that in non-irradiated controls in stages II-V, VII-VIII, and IX-XIII of the cycle, respectively. The corresponding numbers of 1C cells were 5, 17, and 4%. At 52 days after irradiation, 1C cells had declined to 38 and 19% of control values in stages II-V and IX-XIII, respectively. In stages II-V, 1C' cells (haploid cells with condensed nuclei) declined to 28% of controls at 52 days. The present data provide a quantitative basis for the use of X-ray-irradiated rat testes as a model system in experiments pursuing interactions between Sertoli cells and spermatogenic cells.

  4. 255Gy irradiated tachyzoites of Toxoplasma gondii induce intestinal immune response in C57BL/6J immunized by oral route

    Energy Technology Data Exchange (ETDEWEB)

    Galisteo Junior, Andres Jimenez; Alves, Janaina Baptista [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Lab. de Biologia Molecular]. E-mail: galisteo@usp.br; Hiramoto, Roberto Mitsuyoshi [Instituto Adolfo Lutz, Sao Paulo, SP (Brazil). Secao de Parasitoses Sistemicas]. E-mail: hiramoto@usp.br; Carmo, Claudia Villano do; Andrade Junior, Heitor Franco de [Instituto de Medicina Tropical de Sao Paulo, Sao Paulo, SP (Brazil). Lab. de Protozoologia]. E-mail: hfandrad@usp.br

    2005-07-01

    Toxoplasmosis, a prevalent widespread infection in man and animals, occurs mainly through ingestion of water and food contaminated with oocyst from cat feces, causing usually benign disease in humans, except in intrauterine fetal infection or in immunodeficient patients. We study the oral route for the development of a vaccine for toxoplasmosis, using parasites irradiated with 60 Cobalt, as an alternative for vaccine development to this worldwide parasitic infection. We evaluated the development of immunity at serum or mucosal levels, and their efficiency in protect the mice against challenge with oral cysts of the ME-49 strain. C57Bl/6j isogenic mice were immunized by oral route with 10{sup 7} 255 Gy irradiated tachyzoites from RH strain, at several protocols using milk as anti-peptic adjuvant and alum hydroxide as antacid. The preparations of irradiated tachyzoites induced production of serum IgG and IgA in immunized mice, as determined by ELISA, with IgG2a as the dominant subclass, similar to chronic infection. Their use with adjuvant allowed the excretion of significant amounts of IgA in stools also IgG, despite a lesser extent. All oral preparations induced some quantitative protection against challenge, which was similar to the parenteral route only isolated alum hydroxide was used as adjuvant. All these data support the possibility of the development of an oral vaccine against toxoplasmosis, using irradiated tachyzoites, which would be possible tool in near future for use in field baits, for immunizing either domestic or wild felids. (author)

  5. Rectal cancer patients after neoadjuvant radiotherapy (30Gy/10f) with negative lymph node may not benefit from postoperative adjuvant chemotherapy: a retrospective study.

    Science.gov (United States)

    Chen, Pengju; Yao, Yunfeng; Gu, Jin

    2015-12-01

    The purpose of this study is to evaluate whether adjuvant chemotherapy could bring oncologic benefit to all patients who underwent neoadjuvant radiotherapy (30Gy/10f). Rectal cancer patients receiving preoperative radiotherapy between July 2002 and April 2009 were retrospectively identified. A total of 225 patients were enrolled in this study. One hundred thirty-one patients received postoperative adjuvant chemotherapy, and 94 patients did not. The 120 ypN+ and 105 ypN- patients were divided into chemo and non-chemo groups. Two groups of patients did not show any significant difference in terms of gender, age, ypT stage, preoperative serum carcinoembryonic antigen (CEA) level, differentiation, circumferential margin (CRM), lymphovascular invasion (LVI), surgical approach, local recurrence, and distant metastasis (P > 0.05). Survival analysis showed that in ypN+ patients, the 5-year overall survival (OS) rate and 5-year disease-free survival (DFS) rate in chemo group were both significantly higher than non-chemo group (P 0.05). Subgroup analysis showed that the 5-year OS rate and 5-year DFS rate in ypT0-2 N- patients (P > 0.05) and ypT3-4 N- patients (P > 0.05) did not show any significant difference, either. Based on a Chinese protocol, patients with ypN- stage may not benefit from adjuvant chemotherapy, regardless of the ypT stage, while the ypN+ patients may benefit from adjuvant chemotherapy. More randomized clinical trials are needed in the future.

  6. The effect of elevated temperature on the physical properties of Mauthausen Granite (Austria) and Mórágy Granite (Hungary); a comparative study

    Science.gov (United States)

    Török, Anita; Török, Ákos

    2014-05-01

    Elevated temperature cause changes in the physical properties of rocks. The current study provides information on the behaviour of two granitic rocks that were subjected to high temperatures. The two studied lithologies were: i) grey Mauthausen Granite from Upper Austria and a ii) pinkish granite from Mórágy Granite Formation, southern Hungary. The latter one is the host rock of the Hungarian National Radioactive Waste Repository, which is located at Bátaapáti. To assess the changes in physical properties test were made in four conditions: air-dry room temperature (23°C); water saturated room temperature (23°C); after heat shock of 300°C and 600°C, respectively. For the heat tests a furnace was used, in which the temperature was hold on 300°C and 600°C for six hours. The physical parameters were measured according to EN standards or to ISRM guidelines. These included density, determination of ultrasound speed propagation (EN 14579:2005), uniaxial compressive strength (EN 1926:2007), indirect tensile strength (ISRM) and water absorption (EN 13755:2001). The results indicate that there were only minor changes in the densities of both granite types when the samples were heated up to 600°C. To the contrary, the strength parameters showed a clear trend. From room temperature until ~300°C, the uniaxial compressive strength, the modulus of elasticity and the indirect tensile strength showed a slight increase compared to the initial values. This elevated strength decreased significantly when the samples were heated to 600°C. This trend is in good agreement with the previous tests that were made on Indian granites (Dwivedi et al. 2008). Reference: Dwivedi, R. D., R. K. Goel, V.V.R. Prasad, A. Sinha 2008. Thermo-mechanical properties of Indian and other granites. Int. J. Rock Mech. Min. Sci., 45, 3, 303-315.

  7. External Beam Accelerated Partial-Breast Irradiation Using 32 Gy in 8 Twice-Daily Fractions: 5-Year Results of a Prospective Study

    Energy Technology Data Exchange (ETDEWEB)

    Pashtan, Itai M. [Harvard Radiation Oncology Program, Boston, Massachusetts (United States); Recht, Abram [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (United States); Ancukiewicz, Marek [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Brachtel, Elena [Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (United States); Abi-Raad, Rita F. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); D' Alessandro, Helen A. [Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts (United States); Levy, Antonin; Wo, Jennifer Y. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Hirsch, Ariel E. [Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts (United States); Kachnic, Lisa A. [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Goldberg, Saveli [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Specht, Michelle; Gadd, Michelle; Smith, Barbara L. [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Powell, Simon N. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Taghian, Alphonse G., E-mail: ataghian@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2012-11-01

    Purpose: External beam accelerated partial breast irradiation (APBI) is an increasingly popular technique for treatment of patients with early stage breast cancer following breast-conserving surgery. Here we present 5-year results of a prospective trial. Methods and Materials: From October 2003 through November 2005, 98 evaluable patients with stage I breast cancer were enrolled in the first dose step (32 Gy delivered in 8 twice-daily fractions) of a prospective, multi-institutional, dose escalation clinical trial of 3-dimensional conformal external beam APBI (3D-APBI). Median age was 61 years; median tumor size was 0.8 cm; 89% of tumors were estrogen receptor positive; 10% had a triple-negative phenotype; and 1% had a HER-2-positive subtype. Median follow-up was 71 months (range, 2-88 months; interquartile range, 64-75 months). Results: Five patients developed ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial IBTR rate of 5% (95% confidence interval [CI], 1%-10%). Three of these cases occurred in patients with triple-negative disease and 2 in non-triple-negative patients, for 5-year actuarial IBTR rates of 33% (95% CI, 0%-57%) and 2% (95% CI, 0%-6%; P<.0001), respectively. On multivariable analysis, triple-negative phenotype was the only predictor of IBTR, with borderline statistical significance after adjusting for tumor grade (P=.0537). Conclusions: Overall outcomes were excellent, particularly for patients with estrogen receptor-positive disease. Patients in this study with triple-negative breast cancer had a significantly higher IBTR rate than patients with other receptor phenotypes when treated with 3D-APBI. Larger, prospective 3D-APBI clinical trials should continue to evaluate the effect of hormone receptor phenotype on IBTR rates.

  8. PeoplePersonality: Chris Clarke - a physicist who studies ice cream Teaching Anecdotes: Annie Jump Cannon Obituary: György Marx 1927-2002 Starting Out: What Katie did next: part 3 Opinions: What is really important?

    Science.gov (United States)

    2003-03-01

    Featuring relationships, personalities, interactions, environments and reputations involved in physics and education PERSONALITY (156) Chris Clarke - a physicist who studies ice cream TEACHING ANECDOTES (157) Annie Jump Cannon OBITUARY (158) György Marx 1927-2002 Steven Chapman STARTING OUT (159) What Katie did next: part 3 Katie Pennicott OPINIONS (160) What is really important? Kerry Parker

  9. Long-term results of a phase II trial of high-dose radiotherapy (60 Gy) and UFT/l-leucovorin in patients with non-resectable locally advanced rectal cancer (LARC)

    DEFF Research Database (Denmark)

    Vestermark, Lene W; Jakobsen, Anders; Qvortrup, Camilla;

    2008-01-01

    , 52 patients (median age 60 years (32-83); median PS 0 (0-2)) with LARC (36 primary, 16 recurrent) were included in this phase II study. All but three patients received the planned 60 Gy, median duration of RT was 42 days (25-49). Toxicity was very modest; only four patients had a dose reduction...

  10. The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University

    Energy Technology Data Exchange (ETDEWEB)

    Tharavichtikul, Ekkasit; Chitapanarux, Taned; Chakrabandhu, Somvilai; Klunklin, Pitchayaponne; Onchan, Wimrak; Wanwilairat, Somsak; Chitapanarux, Imjai [Faculty of Medicine, Chiang Mai University, Chiang Mai (Thailand); Meungwong, Pooriwat [Lampang Cancer Hospital, Lampang (Thailand); Traisathit, Patrinee [Faculty of Science, Chiang Mai University, Chiang Mai (Thailand); Galalae, Razvan [aculty of Medicine, Christian-Albrechts University at Kiel, Kiei (Germany)

    2014-06-15

    To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale > or = grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). The cumulative rectal dose in EQD2 >65 Gy have association with > or = grade 2 LENT-SOMA scale.

  11. Ferdinandy, György. 2013. Mélyebbre - elbeszélések, jegyzetek (Dig Deeper – Short Stories and Notes. Budapest: Magyar Napló. 296 pp.

    Directory of Open Access Journals (Sweden)

    Mario Fenyő

    2015-01-01

    Full Text Available Ferdinandy, György. 2013. Mélyebbre -  elbeszélések, jegyzetek (Dig Deeper – Short Stories and Notes. Budapest:  Magyar Napló. 296 pp.  Reviewed by Mario Fenyő, Bowie State University, Maryland

  12. Prospective Study Delivering Simultaneous Integrated High-dose Tumor Boost (≤70 Gy) With Image Guided Adaptive Radiation Therapy for Radical Treatment of Localized Muscle-Invasive Bladder Cancer.

    Science.gov (United States)

    Hafeez, Shaista; Warren-Oseni, Karole; McNair, Helen A; Hansen, Vibeke N; Jones, Kelly; Tan, Melissa; Khan, Attia; Harris, Victoria; McDonald, Fiona; Lalondrelle, Susan; Mohammed, Kabir; Thomas, Karen; Thompson, Alan; Kumar, Pardeep; Dearnaley, David; Horwich, Alan; Huddart, Robert

    2016-04-01

    Image guided adaptive radiation therapy offers individualized solutions to improve target coverage and reduce normal tissue irradiation, allowing the opportunity to increase the radiation tumor dose and spare normal bladder tissue. A library of 3 intensity modulated radiation therapy plans were created (small, medium, and large) from planning computed tomography (CT) scans performed at 30 and 60 minutes; treating the whole bladder to 52 Gy and the tumor to 70 Gy in 32 fractions. A "plan of the day" approach was used for treatment delivery. A post-treatment cone beam CT (CBCT) scan was acquired weekly to assess intrafraction filling and coverage. A total of 18 patients completed treatment to 70 Gy. The plan and treatment for 1 patient was to 68 Gy. Also, 1 patient's plan was to 70 Gy but the patient was treated to a total dose of 65.6 Gy because dose-limiting toxicity occurred before dose escalation. A total of 734 CBCT scans were evaluated. Small, medium, and large plans were used in 36%, 48%, and 16% of cases, respectively. The mean ± standard deviation rate of intrafraction filling at the start of treatment (ie, week 1) was 4.0 ± 4.8 mL/min (range 0.1-19.4) and at end of radiation therapy (ie, week 5 or 6) was 1.1 ± 1.6 mL/min (range 0.01-7.5; P=.002). The mean D98 (dose received by 98% volume) of the tumor boost and bladder as assessed on the post-treatment CBCT scan was 97.07% ± 2.10% (range 89.0%-104%) and 99.97% ± 2.62% (range 96.4%-112.0%). At a median follow-up period of 19 months (range 4-33), no muscle-invasive recurrences had developed. Two patients experienced late toxicity (both grade 3 cystitis) at 5.3 months (now resolved) and 18 months after radiation therapy. Image guided adaptive radiation therapy using intensity modulated radiation therapy to deliver a simultaneous integrated tumor boost to 70 Gy is feasible, with acceptable toxicity, and will be evaluated in a randomized trial. Copyright © 2016 The Authors. Published by Elsevier Inc. All

  13. Effects of 2 Gy γ-irradiation on the number of regulatory T cells and Thl7 cells and immune balance in mice%2 Gy γ射线照射对小鼠调节性T细胞和Th17细胞及其免疫平衡的影响

    Institute of Scientific and Technical Information of China (English)

    杨晓云; 杜丽; 马琼; 潘秀颉; 蔡金玲; 肖凤君; 崔玉芳

    2013-01-01

    目的 观察2 Gyγ射线照射对小鼠Treg/Th17免疫平衡的影响.方法 50只C57BL/6雄性小鼠随机数字表法分为对照组和照射组,照射组小鼠接受2Gyγ射线一次性全身照射(剂量率为164.94 Gy/min),对照组行假照射.于照射后1、3、7、14和28 d检测外周血象的变化;流式细胞仪分析外周血、胸腺及脾脏调节性T细胞(Treg细胞)和脾脏Th17细胞数量的改变.结果 受照后小鼠外周血白细胞总数和淋巴细胞数降低(t=8.89 ~33.54,P<0.05).小鼠外周血Treg略有升高;胸腺Treg在照后1、3d显著高于对照组(t=-6.45和-10.59,P<0.05),至28 d明显低于对照组(t =5.34,P<0.05);脾脏Treg在照后1~14 d显著高于对照组(t=-6.82~-3.89,P <0.05).脾脏Th17细胞于照后1d出现显著增高,3d达到最大值(扭-2.42,P<0.05),较脾脏内Treg增长更为明显.Treg/Th17比值在照后1~14 d降低,差异有统计学意义(t=4.02 ~8.04,P<0.05),导致Treg/Th17平衡模式向Th17方向明显偏移.结论 Treg/Th17免疫平衡失调在辐射所致免疫功能损伤中可能扮演重要角色.%Objective To observe the effects of 2 Gy γ-ray irradiation on regulatory T cells (Tregs) and Th17 cells and immune balance of mice.Methods A total of fifty C57BL/6 male mice were randomly divided into two groups,the irradiated group exposed to 2 Gy of whole body γ-ray irradiation,and the control group sham-irradiated.At 1,3,7,14 and 28 d after radiation,changes of peripheral haemogram were detected respectively and Tregs in peripheral blood,thymus and spleen and Th17 cells in spleen were analyzed by flow cytometry.Results Compared with control group,the number of peripheral blood white cells (WBC) and lymphocyte in irradiated group reduced significantly post-irradiation (t =8.89-33.54,P < 0.05),while the cell number of peripheral CD4 + CD25 + Tregs post-irradiation rose but not significantly.Thymic Treg cells increased 1 and 3 d post-irradiation(t =-6.45,-10.59,P <0

  14. 0.5 Gy X线照射对MC3T3-E1成骨细胞基因表达谱的影响%Effects of 0.5 Gy X-ray radiation on the profile of gene expression in MC3T3-E1 osteoblasts

    Institute of Scientific and Technical Information of China (English)

    陈明; 董启榕; 黄群; 徐炜; 佘昶

    2016-01-01

    Objective To investigate the molecular mechanism of low-dose X-ray irradiation on osteoblasts by detecting the gene expression profiles of osteoblasts radiated with 0.5 Gy X-ray.Methods Microarray analyses to value the changes of gene expression of MC3T3-E1 osteoblasts after 0.5 Gy X-ray irradiation were conducted.The end points included modulation of key markers,and pathway and gene ontology through transcriptomic profiling and bioinformatics analysis.Several major genes during osteoblasts differentiation were selected for Real-time PCR analysis.Results 1 412 differentially expressed transcripts were identified between the radiated group and control group.Among the identified genes,559 transcripts were up-regulated and 853 transcripts were down-regulated after irradiation.Real-time PCR analysis indicated that the mRNA expressions of Bglap-rs1,Col1a2,Tgf-β1,Lrp5,Dvl1,Map4k5 were apparently higher than that of the controls (P < 0.01),whereas the Id2 and Dkk1 expression decreased under the same condition (P < 0.01).Western-blot analysis indicated TGF-β1 and Lrp-5 protein expression increased and Dkk1 expression decreased(P < 0.05).Pathway analysis and gene ontology analysis revealed that focal adhesion,extracellular signaling,cytoskeletal protein binding,Wnt signal pathway,IκB/NF-κB signal pathway and growth factor receptors activities.Conclusions Low-dose X-ray radiation promoted osteoblasts differentiation in which focal adhesion,extracellular signaling,cytoskeletal protein binding,Wnt signal pathway,IκB/NF-κB signal pathway and growth factor activities might be involved.%目的 探索低剂量X线促进成骨分化的关分子机制.方法 0.5 Gy X线照射成骨细胞后继续诱导成骨培养,采用基因芯片技术检测X线照射成骨细胞后基因表达谱的变化,筛检出表达差异基因,选取部分骨分化相关基因通过实时聚合酶链反应(real-time PCR)进行验证,并进行基因本体(Gene Ontology,GO)

  15. Safety and Palliative Efficacy of Single-Dose 8-Gy Reirradiation for Painful Local Failure in Patients With Stage IV Non-Small Cell Lung Cancer Previously Treated With Radical Chemoradiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Topkan, Erkan, E-mail: docdretopkan@gmail.com [Baskent Department of Radiation Oncology, University Adana Medical Faculty, Adana (Turkey); Yildirim, Berna Akkus; Guler, Ozan Cem; Parlak, Cem [Baskent Department of Radiation Oncology, University Adana Medical Faculty, Adana (Turkey); Pehlivan, Berrin [Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, and American Hospital, University of Texas MD Anderson Radiation Treatment Center, Istanbul (Turkey); Selek, Ugur [Medstar Hospital, Department of Radiation Oncology, Antalya (Turkey)

    2015-03-15

    Purpose: To investigate the safety and efficacy of single-dose 8-Gy palliative chest reirradiation (CRI) in metastatic non-small cell lung cancer (M-NSCLC) patients with painful thoracic failures (TF) within the previous radiation portal. Patients and Methods: We retrospectively analyzed the clinical data of 78 M-NSCLC patients who received single-dose 8-Gy CRI for painful TF after concurrent chemoradiation therapy to a total radiation dose of 52 to 66 Gy between 2007 and 2012. Primary endpoints included significant pain relief (SPR) defined as a ≥2 point decrement in the Visual Analogue Scale for Pain inventory (VAS-P), time to pain relief, and duration of pain control. Secondary objectives were survival and prognostic factors. Results: Treatment was well tolerated, with only 5.1% grade 3 pneumonitis and 1.3% grade 2 esophagitis. Pre-CRI median and post-CRI minimum VAS-P were 7 and 3 (P<.001), respectively. SPR was noted in 67 (85.9%) patients, and only 3 (3.9%) scored progressive pain. Median time to lowest VAS-P and duration of pain control were 27 days and 6.1 months, respectively. Median overall survival (OS) was 7.7 months, and the 1-year OS rate was 26.5%. On multivariate analyses, lower Eastern Cooperative Oncology group score (1-2; P<.001), absence of anemia (P=.001), and fewer metastatic sites (1-2; P<.001) were found to be associated with longer OS. Conclusions: Single-dose 8-Gy CRI provides safe, effective, and durable pain palliation for TF in radically irradiated M-NSCLC patients. Because of its convenience, lower cost, and higher comfort, the present protocol can be considered an appropriate option for patients with limited life spans.

  16. 2Gyγ射线照射后24h大鼠周围血淋巴细胞基因表达谱研究%Study on gene expression profiling in peripheral blood lymphocytes of rats 24 hours after exposure to 2 Gy gamma ray

    Institute of Scientific and Technical Information of China (English)

    尹晶晶; 张伟; 李建国; 安全; 秦秀军; 闻建华

    2015-01-01

    目的:利用基因芯片技术研究2 Gyγ射线离体和全身照射后24 h对大鼠周围血淋巴细胞基因表达的影响。方法采用2 Gy钴-60(60Co)γ射线对无特定病原体级雄性SD大鼠分别进行离体和全身照射,于照射后24 h提取周围血淋巴细胞RNA,应用基因芯片技术进行辐射差异表达基因筛选,应用基因本体( GO)和京都基因与基因组百科全书( KEGG)数据库对差异表达基因进行生物信息学分析,并应用实时荧光定量聚合酶链反应( PCR)技术对基因芯片结果进行验证。结果离体照射组和全身照射组分别筛选出差异表达3倍以上的基因6925和3938条。2组共同差异表达3倍以上的基因有1322条;GO富集分析结果表明差异表达基因涵盖于生物学过程、细胞组分和分子功能3个分类;KEGG富集分析结果表明,离体照射组差异表达基因涉及41个生物学通路,全身照射组差异表达基因涉及38个生物学通路,2组涉及12个共同的生物学通路;离体照射组与全身照射组共同差异表达的基因涉及8个生物学通路;随机选择2条差异表达基因进行mRNA水平的验证,结果显示PCR扩增结果与基因芯片结果具有良好的一致性。结论60 Coγ射线照射所致大鼠周围血淋巴细胞的差异表达基因和信号通路主要涉及细胞凋亡、细胞周期、信号转导及DNA损伤修复等多个方面。%Objective To explore the impacts on peripheral blood lymphocyte gene expression of SD rats by microarray technology 24 hours after in vitro and whole-body exposure to 2 Gy gamma ray.Methods Specific pathogen free male SD rats were in vitro and whole-body respectively exposed to Co-60 gamma ray at 2 Gy, RNA was extracted from peripheral blood lymphocytes 24 hours after irradiation, the method of microarray was applied for screening differentially expressed genes.Bioinformatics analysis of differentially expressed genes were

  17. Long-term results of a phase II trial of high-dose radiotherapy (60 Gy) and UFT/l-leucovorin in patients with non-resectable locally advanced rectal cancer (LARC)

    Energy Technology Data Exchange (ETDEWEB)

    Vestermark, Lene W.; Qvortrup, Camilla; Baatrup, Gunnar; Pfeiffer, Per (Odense Univ. Hospital, Odense (Denmark)); Bisgaard, Claus; Jacobsen, Anders (Vejle Hospital, Vejle (Denmark)); Hansen, Flemming; Rasmussen, Peter (Aarhus Univ. Hospital, Aarhus (Denmark))

    2008-03-15

    Background. Preoperative radiochemotherapy is a cornerstone in patients with non-resectable locally advanced rectal cancer (LARC). To improve outcome (number of R0 resections and survival) high-dose radiotherapy (RT) was combined with oral UFT/l-leucovorin to allow tumour regression before radical intended surgery. Methods. Pelvic RT was delivered with megavoltage photons using a 5 field technique. RT was CT-based, given 5 days a week through one posterior field and two lateral fields (48.6 Gy/27 fractions) to encompass the primary tumour and the regional lymph nodes. In addition, the tumour bed received a concurrent boost (5.4 Gy/27 fractions) and a final boost (6 Gy/3 fractions); thus GTV received 60 Gy/30 fractions. Concurrent with RT patients received a daily dose of oral UFT 300 mg/m2 plus l-leucovorin 22.5 mg 5/7days (divided in three doses). Results. From September 2000 to November 2004, 52 patients (median age 60 years (32-83); median PS 0 (0-2)) with LARC (36 primary, 16 recurrent) were included in this phase II study. All but three patients received the planned 60 Gy, median duration of RT was 42 days (25-49). Toxicity was very modest; only four patients had a dose reduction of UFT. No hematological toxicity of clinical significance was seen. Non-hematological toxicity grade 1 (GI-toxicity, fatigue and/or dysuria) was frequently observed but only four patients experienced grade 3 toxicity (diarrhoea and/or nausea/vomiting). Forty patients (77%) were operated (30 R0, 5 R1, 5 R2) median 55 days (27-112) after completion of RT. Seven (13%) patients had a pathological complete response (pCR). Thirty-one patients (60%) died after median 25.4 months (1.6-45.2 months). Twenty-one patients (40%) are still alive June 2007. Conclusions. Preoperative high-dose RT and concomitant UFT produces major regression in most patients with non-resectable LARC and thus a good chance of cure

  18. Evaluation of the cell death mechanisms activated by the radiopharmaceutical {sup 177}Lu-DOTA-anti-CD20 in a dose range of 1 to 5 Gy; Evaluacion de los mecanismos de muerte celular activados por el radiofarmaco {sup 177}Lu-DOTA-anti-CD20 en un intervalo de dosis de 1 a 5 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Azorin V, E.P.; Rojas C, E. L.; Martinez V, B. E.; Ramos B, J. C.; Jimenez M, N. P.; Ferro F, G., E-mail: erica.azorin@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2016-10-15

    The radio immunotherapy with anti-CD20 antibodies significantly increases the remission rate of patients with B-cell lymphomas over expressing the CD20. The radiolabeled antibodies directed to surface antigens allow delivering scaled doses of radiation to specific targets thus limiting the dose to healthy tissue. The anti-CD20 causes cell death by two major pathways; activating the immune system to destroy malignant cells and inducing the activation of cell death pathways. The {sup 177}Lu is a beta particle emitter (max. 0.497 MeV) with a maximum reach on soft tissue of 0.7 mm and a half-life of 6.7 days. Several clinical studies have established a maximum tolerated dose (45 m Ci/m{sup 2}) for {sup 177}Lu-DOTA-rituximab, which shows a favorable clinical response without hematological toxicity. However, the molecular mechanisms of action by synergistic effect of anti-CD20 and radionuclide have not been studied. In this work was evaluated; by flow cytometry, the activation kinetics of the cell death mechanisms induced by the treatment with {sup 177}Lu-DOTA-Anti-CD20 in non-Hodgkin (Raji) lymphoma cells. The absorbed radiation dose delivered to the cell nucleus was calculated by Monte Carlo simulation, considering the contribution of the beta emissions of the radiopharmaceutical present in the cell membrane and surrounding environment, as well as crossfire. This work shows that the application of radiation doses of 1 to 5 Gy of the radiopharmaceutical {sup 177}Lu-DOTA-anti-CD20, are sufficient to induce cell death by apoptosis and arrest of the cell cycle. The combination of these factors (continuous delivery of radiation, activation of repair mechanisms and increased radio sensitivity) causes the acute activation of the apoptotic program resulting in significant cell death after 96 h of treatment. The temporal analysis of cell death suggests the early activation of apoptosis that is counteracted by the activation of repair processes caused by sustained irradiation

  19. Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54-56 Gy given in 9-7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size.

    Science.gov (United States)

    Aoki, Masahiko; Sato, Mariko; Hirose, Katsumi; Akimoto, Hiroyoshi; Kawaguchi, Hideo; Hatayama, Yoshiomi; Ono, Shuichi; Takai, Yoshihiro

    2015-04-22

    Radiation-induced rib fracture after stereotactic body radiotherapy (SBRT) for lung cancer has been recently reported. However, incidence of radiation-induced rib fracture after SBRT using moderate fraction sizes with a long-term follow-up time are not clarified. We examined incidence and risk factors of radiation-induced rib fracture after SBRT using moderate fraction sizes for the patients with peripherally located lung tumor. During 2003-2008, 41 patients with 42 lung tumors were treated with SBRT to 54-56 Gy in 9-7 fractions. The endpoint in the study was radiation-induced rib fracture detected by CT scan after the treatment. All ribs where the irradiated doses were more than 80% of prescribed dose were selected and contoured to build the dose-volume histograms (DVHs). Comparisons of the several factors obtained from the DVHs and the probabilities of rib fracture calculated by Kaplan-Meier method were performed in the study. Median follow-up time was 68 months. Among 75 contoured ribs, 23 rib fractures were observed in 34% of the patients during 16-48 months after SBRT, however, no patients complained of chest wall pain. The 4-year probabilities of rib fracture for maximum dose of ribs (Dmax) more than and less than 54 Gy were 47.7% and 12.9% (p = 0.0184), and for fraction size of 6, 7 and 8 Gy were 19.5%, 31.2% and 55.7% (p = 0.0458), respectively. Other factors, such as D2cc, mean dose of ribs, V10-55, age, sex, and planning target volume were not significantly different. The doses and fractionations used in this study resulted in no clinically significant rib fractures for this population, but that higher Dmax and dose per fraction treatments resulted in an increase in asymptomatic grade 1 rib fractures.

  20. MODELO DE GESTIÓN DE CONTROL DE COSTOS, EN LA INDUSTRIA DE LA CONSTRUCCIÓN, BAJO EL ENFOQUE DEL PMI-PMBOK; CASO PRESA DE RELAVE, CONSORCIO STRACON GyM-MOTAENGIL, MINERA CHINALCO, PERÚ

    OpenAIRE

    MAÑUICO MENDOZA, ROBERTO

    2016-01-01

    Durante el 2011 y 2012, en el consorcio de las empresas StraconGyM y Mota-Engil Perú, en el proyecto CC-02 “Construcción de Presa de Relave y Facilidades”, se implementó la gestión de control de costos, bajo el enfoque del PMI-PMBOK (Projetc Management Institute-Projetc Management Body of Knowledge). La investigación tuvo el objetivo de determinar en qué medida la implementación del modelo de gestión de control de costos bajo el enfoque del PMI-PMBOK, permite mejorar la eficiencia del cost...

  1. Response of mesenchymal stem cells in mice to 3.5 Gy X-ray irradiation%3.5Gy X射线对小鼠间充质干细胞的损伤及其机制的研究

    Institute of Scientific and Technical Information of China (English)

    苏文霞; 刘荟敏; 陈永红; 曾雯; 刘文励; 孙汉英

    2011-01-01

    Objective To investigate the response of mesenchymal stem cells in mice to mediumdose X-ray irradiation in vitro.Methods The mouse mesenchymal stem cell line C3H10T1/2 was submitted to 3.5 Gy X-ray irradiation.Hoechst33258 staining of adherent cells and Annexin V-FITC staining and flow cytometry analysis of suspension cells were performed respectively to assess cellular apoptosis at 3,6,12,24,48,72 h and 1 week after irradiation.SA-β-gal staining was performed to analyze the cellular senescence at 24,48,72 h and 1 week after irradiation.The mRNA level of both Fas with its ligand FasL and p53 with its downstream target p21 WAF1 were measured by Real-Time PCR analysis.The expression of Fas protein was determined by immunofluorescence staining.Results An increased apoptosis was observed at 3 h after irradiation with apoptosis rate 11.72% ± 1.61% ( t =9.01,P <0.01 ),the apoptosis rate reached the peak level at 12 h 20.52% ± 1.96% (t =16.27,P < 0.01 ),and then declined progressively to normal level at 48 h 4.93% ±0.46% (t =2.26,P >0.05).The SA-β-gal positive rate of post-radiation cells at 72 h was 53.33% ± 5.62%,significantly higher than that of normal control 3.24% ± 0.39% (t =17.77,P < 0.01 ).The level of Fas,FasL mRNA was found to be elevated 3 h after irradiation with a peak at 12 h,and no differences were found l week later.The level of Fas protein was observed to reach the peak at 12 h after irradiation.The occurrence of peak level of Fas/FasL mRNA and protein was consistent with that of apoptosis of C3H10T1/2 cell.A transient up-regulation of p53,p21 WAF1 mRNA expression was found at 12 h after irradiation followed by a significant increase later at 72 h after irradiation.The occurrence of the two peaks of p53,p21WAF1 mRNA expression were coincident with that of cellular apoptosis and senescence,respectively.The levels of p53,p21WAF1 mRNA in senescence group were significantly higher than those of apoptosis group ( t =17

  2. A szervezeti változással szembeni ellenállás mint természetes és szükségszerű gyászfolyamat

    OpenAIRE

    Pulinka, Ágnes

    2016-01-01

    A változás mint szervezet- és vezetéstudományi téma már régóta divatos, de napjainkra lett megkerülhetetlen azok számára, akik szervezetekkel vagy szervezetekben dolgoznak. A változással való személyes, érzelmi megküzdés és a gyászfolyamat közötti erőteljes hasonlóság sem újdonság, de a gyász egyik legismertebb nemzetközi szakértője, Elizabeth Kübler-Ross modelljének explicit vezetéstudományi alkalmazása a magyar szakirodalomban eddig hiánynak mutatkozott. A szerző cikkében ezt kívánja pót...

  3. Comparison of DSB effects of the beta particles of iodine-131 and 6 MV X-ray at a dose of 2 Gy in the presence of 2-Methoxyestradiol, IUdR, and TPT in glioblastoma spheroids

    Science.gov (United States)

    Neshasteh-Riz, Ali; Eyvazzadeh, Nazila; Koosha, Fereshteh; Cheraghi, Susan

    2017-02-01

    Glioblastoma is one of the lethal brain tumors and one of the resistant tumors against radiotherapy. Multiple treatment methods and different types of radiation and Radiosensitizers drugs have been combined to optimize the efficacy of radiotherapy. Radiosensitizers are employed to reinforce tumor cell killing and have much fewer effects on the normal tissue. Inducing DNA double strand break in tumoral cells is a major goal of radiation sensitivity. In this study, the level of DNA double strand break in glioblastoma spheroids irradiated by 2 Gy beta particles of iodine-131 and 6 MV X-rays in the presence of 2-Methoxyestradiol (2ME2), iodo-deoxy-uridine (IUdR) and Topotecan (TPT) was measured using the PicoGreen method. Spheroids of the U87MG cell line were cultured to reach a 300 μm diameter. In the phase one of the study, the spheroids were treated in four groups individually, including 2 Gy of iodine-131, TPT+iodine-131, IUdR+iodine-131, IUdR+2ME2+iodine-131. In the next phase, the cells were treated with 2 Gy of 6 MV X-ray, TPT+6 MV X-ray, IUdR+6 MV X-ray, TPT+IUdR+6 MV X-ray. DSB lesions were measured by the Pico Green assay. The amount of DSB lesions in groups irradiated with iodine-131 individually was greater than the group irradiated with 6 MV X-ray (pindependent groups of TPT+IUdR+2ME2+iodine-131 and TPT+IUdR+2ME2+6 MV X-ray was approximately in the same range (P>0.05). The level of DNA double strand breaks in cells irradiated with Iodine-131 was higher than cells irradiated with 6 MV X-ray at the same dose and Topotecan had a positive effect on inducing the damage. The role of 2ME2+IUdR in increasing the damage caused by beta particles of iodine-131 was not significant. Iodine-131 could lead to major DSB damage than 6 MV X-ray at the same dose due to its cross fire effect and spatial distribution of energy in different angels. This study showed that a combination of chemotherapy and iodine-131 had better efficacy than radiotherapy with 6 MV X-ray in the

  4. Dose-Fractionation Sensitivity of Prostate Cancer Deduced From Radiotherapy Outcomes of 5,969 Patients in Seven International Institutional Datasets: {alpha}/{beta} = 1.4 (0.9-2.2) Gy

    Energy Technology Data Exchange (ETDEWEB)

    Miralbell, Raymond, E-mail: Raymond.Miralbell@hcuge.ch [University Hospital, Geneva (Switzerland); Institut Oncologic Teknon, Barcelona (Spain); Roberts, Stephen A. [Health Sciences-Methodology, Manchester Academic Health Sciences Centre, University of Manchester, Manchester (United Kingdom); Zubizarreta, Eduardo [International Atomic Energy Agency, Vienna (Austria); Hendry, Jolyon H. [Adlington, Macclesfield (United Kingdom)

    2012-01-01

    Purpose: There are reports of a high sensitivity of prostate cancer to radiotherapy dose fractionation, and this has prompted several trials of hypofractionation schedules. It remains unclear whether hypofractionation will provide a significant therapeutic benefit in the treatment of prostate cancer, and whether there are different fractionation sensitivities for different stages of disease. In order to address this, multiple primary datasets have been collected for analysis. Methods and Materials: Seven datasets were assembled from institutions worldwide. A total of 5969 patients were treated using external beams with or without androgen deprivation (AD). Standard fractionation (1.8-2.0 Gy per fraction) was used for 40% of the patients, and hypofractionation (2.5-6.7 Gy per fraction) for the remainder. The overall treatment time ranged from 1 to 8 weeks. Low-risk patients comprised 23% of the total, intermediate-risk 44%, and high-risk 33%. Direct analysis of the primary data for tumor control at 5 years was undertaken, using the Phoenix criterion of biochemical relapse-free survival, in order to calculate values in the linear-quadratic equation of k (natural log of the effective target cell number), {alpha} (dose-response slope using very low doses per fraction), and the ratio {alpha}/{beta} that characterizes dose-fractionation sensitivity. Results: There was no significant difference between the {alpha}/{beta} value for the three risk groups, and the value of {alpha}/{beta} for the pooled data was 1.4 (95% CI = 0.9-2.2) Gy. Androgen deprivation improved the bNED outcome index by about 5% for all risk groups, but did not affect the {alpha}/{beta} value. Conclusions: The overall {alpha}/{beta} value was consistently low, unaffected by AD deprivation, and lower than the appropriate values for late normal-tissue morbidity. Hence the fractionation sensitivity differential (tumor/normal tissue) favors the use of hypofractionated radiotherapy schedules for all risk

  5. Effect of antihistamines, disodium cromoglycate (DSCG) or methysergide on post-irradiation cerebral blood flow and mean systemic arterial blood pressure in primates after 25 Gy, whole-body, gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Cockerham, L.G.; Forcino, C.D. [Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)

    1995-06-01

    Exposure to ionizing radiation causes hypotension, cerebral ischemia and release of histamine (HA) and serotonin (5-HT). To investigate the relationship among these responses, rhesus monkeys (Macaca mulatta) received physiological saline (i.v.), disodium cromoglycate (DSCG), antihistamines (AH, mepyramine and cimetidine), or methysergide (METH), then were given 25 Gy whole-body irradiation. Monkeys receiving DSCG, AH or METH had higher post-irradiation mean arterial blood pressure (MBP) than saline-treated controls. Compared to levels in controls, post-irradiation hippocampal blood flow (rCBF) levels were higher in monkeys receiving DSCG, AH or METH. Treatment with the 5-HT{sub 2} receptor antagonist methysergide was the most effective in maintaining both rCBF and MBP after irradiation. Results support the hypothesis that the irradiation-induced cerebral ischemia and, to some extent, the hypotension is mediated by serotonin through 5-HT{sub 2} receptor sites. (author) 72 refs.

  6. Comment on 'Investigations into the impact of astronomical phenomena on the terrestrial biosphere and climate' (arXiv:1505.07856 [astro-ph.EP]) by Fabo Feng

    CERN Document Server

    Melott, Adrian L

    2015-01-01

    This work by Feng and papers which published its conclusions do not cite nor do they deal with objections by the author published in 2013-2014. There are many fundamental problems. We will summarize here the principal problems, as published by Melott and Bambach which render irrelevant most of the work presented by Feng.

  7. A unique hypofractionated radiotherapy schedule with 51.3 Gy in 18 fractions three times per week for early breast cancer: outcomes including local control, acute and late skin toxicity.

    Science.gov (United States)

    Vassilis, Kouloulias; Ioannis, Gogalis; Anna, Zygogianni; Christina, Armpilia; Christos, Antypas; John, Kokakis; Porfyrios, Koromperlis; Vassiliki, Gennimata; John, Kouvaris

    2017-03-01

    Evaluation of local control and acute and late toxicity regarding a hypofractionated RT schedule for breast cancer patients. Between October 2007 and October 2009, 80 women with early breast cancer were treated by 42.75 Gy in 15 fractions over 5 weeks. This treatment involved three fractions per week (Monday-Wednesday-Friday). All patients received an additional boost dose to the tumor bed of 8.55 Gy in 3 fractions using 6 MV photons. The primary endpoint included any local recurrence in the treated breast. Secondary endpoint included acute and late radiation skin toxicity. The median follow-up time was 63 months (range 60-72). Radiation toxicity was graded according the RTOG/EORTC criteria. Neither local nor distant recurrence was noted in any patient during this 3-year follow-up. Grade 0, 1, 2 acute skin toxicity was observed in 56/80 (70.0 %), in 19/80 (23.8 %) and in 5/80 (6.3 %), respectively. Three months post-RT, toxicity grades 0, 1, 2 skin toxicity were 64/80 (80 %), 14/80 (17.5 %) and 2/80 (2.5 %), respectively. Late toxicity as grade 0, 1 was observed in 72/80 (90.0 %) and in 8/80 (10.0 %), respectively, 6 months post-RT, whereas after 1 year they were 78/80 (97.5 %) and 2/80 (2.5 %), respectively. Preliminary results regarding skin reactions, cosmetic appearance and local control are consistent with published data that support the use of shorter fractionation schedules in early breast cancer patients after breast conservative surgery. Longer follow-up and a randomized prospective study stand in need for the extraction of safe conclusions.

  8. O tema da morte trágica de Liev Tolstói e seu impacto em Max Weber e György Lukács: sobre a autonomia nas ciências e na arte * Leo Tolstoy´s tragic death and his impacts on Max Weber and György Lukács: on autonomy of arts and science

    Directory of Open Access Journals (Sweden)

    LUIS FELIPE DE SALLES ROSELINO

    2014-04-01

    Full Text Available Resumo: O tema da morte trágica, presente nos escritos de Liev Tolstói, auxiliou tanto a Max Weber como a György Lukács a caracterizarem o pathos moderno de pressentimento da morte como uma contemplação do vazio. Weber e Lukács encontraram, através das leituras de Tolstói, uma interessante maneira de questionar a autonomia da arte e da ciência moderna, considerando pela esfera estética, como se mostra sem sentido a recente realidade imanente. Ambos assumiram o tema central das obras de Tolstói segundo uma mesma imagem, derivada do contraste entre o mundo antigo e o moderno. Max Weber adequou esse tema a sua teoria do desencantamento do mundo e Lukács, de modo muito semelhante, seguindo seu conceito do paradoxo da necessidade religiosa.Palavras-chave: Tolstói – Weber – Lukács – Desencantamento – Necessidade Religiosa – L’Art Pour l’Art. Abstract: The tragic death in Tolstoy's writings has helped both Max Weber and György Lukács in characterizing the modern pathos as a tragic contemplation of the emptiness of life. Through Tolstoy's readings, Weber and Lukács found an interesting source of denying arts and modern sciences autonomy, considering, from the aesthetics sphere, the meaningless of this new immanent reality. Both has assumed Tolstoy main theme from the same perspective, contrasting ancient and modern worldviews. Max Weber presented this theme in his disenchantment of world theory and Lukács, in a very similar way, following the paradox of religious needing as a mainline.Keywords: Tolstoy – Weber – Lukács – Disenchantment – Religious Needing – L’Art Pour l’Art.

  9. Studies on mechanism of treatment of granulocyte colony-stimulating factor,recombinant human interleukin-11 and recombinant human interleukin-2 on hematopoietic injuries induced by 4.5 Gy γ-rays irradiation in beagles%细胞因子治疗4.5 Gyγ射线照射比格犬造血损伤的机制初探

    Institute of Scientific and Technical Information of China (English)

    李明; 王金香; 缪竞诚; 朱南康; 罗庆良; 从玉文; 张学光; 欧红玲; 邢爽; 黄海潇; 熊国林; 谢玲; 赵燕芳; 赵振虎; 王宁

    2010-01-01

    目的 探讨多种细胞因子配伍应用治疗4.5 Gyγ射线照射比格犬造血系统损伤的作用及可能机制.方法 16只比格犬均给予4.5 Gy60Coγ射线全身照射,随机分为照射对照、综合对症和细胞因子3组.细胞因子组在综合对症支持治疗的基础上应用rhG-CSF、rhIL-11和rhIL-2联合治疗,采用流式细胞术检测外周血中CD34+细胞含量、有核细胞周期及凋亡比例.结果 4.5 Gyγ射线照射犬外周血中CD34+细胞含量在照射后1 d明显下降(照射对照组和综合对症组分别为照前值的61.3%和52.1%),G0/G1期有核细胞比例增加(分别为99.27%和99.49%),且凋亡率(分别为26.93%和21.29%)和坏死率(分别为3.27%和4.14%)明显升高(与照前值比较,P<0.05);而经过细胞因子治疗后,外周血中CD34+细胞含量在照射后1 d即明显升高(为照前值的135.6%),G0/G1期有核细胞比例(99.71%)进一步增加,其凋亡率(5.66%)和坏死率(1.60%)明显低于照射对照和综合对症组.结论 本研究的细胞因子组合可能通过动员骨髓中CD34+细胞到外周血,使细胞周期阻滞在G0/G1期,减少细胞凋亡,从而促进极重度骨髓型急性放射病犬造血功能的恢复.%Objective To investigate the mechanism of treatment of granulocyte colony-stimulating factor(rhG-CSF),recombinant human interleukin-11(rhIL-11)and recombinant human interleukin-2 (rhIL-2)on hematopoietic injuries induced by 4.5 Gy60 Coγ-ray irradiation in beagles,and to provide experimental evidence for the clinical treatment of extremely severe myeloid acute radiation sickness (ARS).Methods Sixteen beagle dogs were given 4.5 Gy60 Co γ-ray total body irradiation(TBI),then randomly assigned into irradiation control group,supportive care group or cytokines+supportive care (abbreviated as cytokines)group.In addition to supportive care,rhG-CSF,rhlL-11 and rhIL-2 were administered subcutaneously to treat dogs in cytokines group.The percentage of CD34+cells,cell cycle and

  10. Survival Fraction at 2 Gy and γH2AX Expression Kinetics in Peripheral Blood Lymphocytes From Cancer Patients: Relationship With Acute Radiation-Induced Toxicities

    Energy Technology Data Exchange (ETDEWEB)

    Pouliliou, Stamatia E. [Department of Radiotherapy/Oncology, Radiobiology and Radiopathology Unit, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Lialiaris, Theodoros S. [Department of Medical Genetics, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Dimitriou, Thespis [Department of Anatomy, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Giatromanolaki, Alexandra [Department of Pathology, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Papazoglou, Dimitrios [Department of Internal Medicine, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Pappa, Aglaia [Department of Molecular Biology and Genetics, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Pistevou, Kyriaki [Department of Radiotherapy/Oncology, Aristotle University of Thessalonica, Thessalonica (Greece); Kalamida, Dimitra [Department of Radiotherapy/Oncology, Radiobiology and Radiopathology Unit, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece); Koukourakis, Michael I., E-mail: targ@her.forthnet.gr [Department of Radiotherapy/Oncology, Radiobiology and Radiopathology Unit, School of Health Sciences, Democritus University of Thrace, Alexandroupolis (Greece)

    2015-07-01

    Purpose: Predictive assays for acute radiation toxicities would be clinically relevant in radiation oncology. We prospectively examined the predictive role of the survival fraction at 2 Gy (SF2) and of γH2AX (double-strand break [DSB] DNA marker) expression kinetics in peripheral blood mononuclear cells (PBMCs) from cancer patients before radiation therapy. Methods and Materials: SF2 was measured with Trypan Blue assay in the PBMCs from 89 cancer patients undergoing radiation therapy at 4 hours (SF2{sub [4h]}) and 24 hours (SF2{sub [24h]}) after ex vivo irradiation. Using Western blot analysis and band densitometry, we further assessed the expression of γH2AX in PBMC DNA at 0 hours, 30 minutes, and 4 hours (33 patients) and 0 hour, 4 hours, and 24 hours (56 patients), following ex vivo irradiation with 2 Gy. Appropriate ratios were used to characterize each patient, and these were retrospectively correlated with early radiation therapy toxicity grade. Results: The SF2{sub (4h)} was inversely correlated with the toxicity grade (P=.006). The γH2AX-ratio{sub (30min)} (band density of irradiated/non-irradiated cells at 30 minutes) revealed, similarly, a significant inverse association (P=.0001). The DSB DNA repair rate from 30 minutes to 4 hours, calculated as the relative RγH2AX-ratio (γH2AX-ratio{sub (4h)}/γH2AX-ratio{sub (30min)}) showed a significant direct association with high toxicity grade (P=.01). Conclusions: Our results suggest that SF2 is a significant radiation sensitivity index for patients undergoing radiation therapy. γH2AX Western blot densitometry analysis provided 2 important markers of normal tissue radiation sensitivity. Low γH2AX expression at 30 minutes was linked with high toxicity grade, suggesting that poor γH2AX repair activity within a time frame of 30 minutes after irradiation predicts for poor radiation tolerance. On the other hand, rapid γH2AX content restoration at 4 hours after irradiation, compatible with

  11. Performance in hippocampus- and PFC-dependent cognitive domains are not concomitantly impaired in rats exposed to 20 cGy of 1 GeV/n 56Fe particles

    Science.gov (United States)

    Britten, Richard A.; Miller, Vania D.; Hadley, Melissa M.; Jewell, Jessica S.; Macadat, Evangeline

    2016-08-01

    NASA is currently conducting ground based experiments to determine whether the radiation environment that astronauts will encounter on deep space missions will have an impact on their long-term health and their ability to complete the various tasks during the mission. Emerging data suggest that exposure of rodents to mission-relevant HZE radiation doses does result in the impairment of various neurocognitive processes. An essential part of mission planning is a probabilistic risk assessment process that takes into account the likely incidence and severity of a problem. To date few studies have reported the impact of space radiation in a format that is amenable to PRA, and those that have only reported data for a single cognitive process. This study has established the ability of individual male Wistar rats to conduct a hippocampus-dependent (spatial memory) task and a cortex-dependent (attentional set shifting task) 90 days after exposure to 20 cGy 1 GeV/n 56Fe particles. Radiation-induced impairment of performance in one cognitive domain was not consistently associated with impaired performance in the other domain. Thus sole reliance upon a single measure of cognitive performance may substantially under-estimate the risk of cognitive impairment, and ultimately it may be necessary to establish the likelihood that mission-relevant HZE doses will impair performance in the three or four cognitive domains that NASA considers to be most critical for mission success, and build a PRA using the composite data from such studies.

  12. A phosphate group at the cos ends of phage lambda DNA is not a prerequisite for in vitro packaging: an alternative method for constructing genomic libraries using a new phasmid vector, lambda pGY97.

    Science.gov (United States)

    Vincze, E; Kiss, G B

    1990-11-30

    It is shown here that the phosphate groups at the cos ends of phage lambda DNA are not a prerequisite for in vitro packaging. Molecules with phosphatase-treated cos ends are packaged in vitro as efficiently as native lambda DNA. This observation can be used for an alternative strategy to improve the efficiency of gene library construction, since cos-cos ligation decreases in vitro encapsidation and infectivity. Dephosphorylated cos ends and a new phasmid vector lambda pGY97 have been used to construct a representative gene bank of alfalfa in a Mcr- (5-methylcytosine restriction deficient) Escherichia coli host strain. These recombinant clones can be propagated as phages or more conveniently as plasmids in recA- E. coli, to prevent possible homologous recombination events between repetitive sequences of the insert that would otherwise interfere with clone stability. The 5-19-kb inserts can be easily recloned as plasmids from the recombinant phasmids with simple EcoRI digestion and re-ligation. This observation also implies that the construction of gene libraries in cosmid vectors can be made more efficient if cos-cos ligates were cleaved by lambda terminase just before in vitro packaging.

  13. Influence of age on radioinduced cognitive disorders: Experimental studies with cerebral irradiation of 30 Gy in 10 sessions and 12 days in the Wistar rat at 1.5, 4 and 18 months; Influence de l'age sur les troubles cognitifs radioinduits : etudes experimentales avec irradiation cerebrale de 30 Gy en 10 seances et 12 jours chez le rat Wistar de 1 1/2, 4 et 18 mois

    Energy Technology Data Exchange (ETDEWEB)

    Lamproglou, I. [Lab. de Chimie et Biophysique des Traceurs, Faculte de Medecine Xavier Bichat, Paris (France); Baillet, F.; Boisserie, G.; Mazeron, J.J. [Service de Radiotherapie, Hopital de la Pitie-Salpetriere, Paris (France); Delattre, J.Y. [Dept. of Neurology and Inst. National de la Sante et de la Recherche Medicale, INSERM, Hopital de la Pitie-Salpetriere, Paris (France)

    2002-07-01

    The objective of this study was to determine the influence of age on the learning and memory dysfunction induced by cranial radiation in the male Wistar rat. Ninety-six 45-day-old, 70 4-month-old, and 78 18-month-old male rats were divided in two equal groups: (i) irradiated and (ii) control. A course of whole-brain radiation therapy (30 Gy in 10 fractions over 12 days) was administered to the irradiated group, while the control group received sham irradiation. Sequential behavioral studies including one and two-way avoidance tests were undertaken before and after the 7 months following radiation. The results suggest that radiation induced progressive and irreversible memory dysfunction in elderly (18-month-old) rats, but this effect was partial or almost reversible in the 4-month-old and 45-day-old rats, respectively. In return, the learning dysfunction was age non-dependent despite the fact that is occurs more rapidly in the young (45 days, 4 months) rats. (author)

  14. MMPs/TIMPs系统在小鼠急性放射性肺损伤中的表达%Increased expressions of MMP-2 and MMP-9 in lung following 12 Gy local irradiation

    Institute of Scientific and Technical Information of China (English)

    杨坤禹; 刘莉; 张涛; 胡豫; Claudia Ruebe; Christian Ruebe; 伍钢

    2006-01-01

    目的 通过检测基质金属蛋白酶(MMPs)和基质金属蛋白酶组织抑制物(TIMPs)在单次大剂量胸部照射小鼠肺组织中的表达,探讨全肺照射诱导的MMPs/TIMPs系统表达紊乱在放射性肺损伤发生与发展中的作用.方法 实验组小鼠在出生后8周时给予单次胸部照射12 Gy,对照组小鼠给予假照射.在照射后4和8周时处死小鼠,收集肺组织标本,测定肺组织中MMP-2、MMP-9、MMP-3、MMP-13、TIMP-1、TIMP-2和TIMP-3蛋白的表达.结果 照射后4和8周时,实验组小鼠肺组织中MMP-2表达水平分别为对照组的1.7和1.9倍,MMP-9表达水平分别为对照组的2.7和2.6倍,而MMP-3、MMP-13、TIMP-1、TIMP-2、和TIMP-3的表达水平与对照组比较无显著改变.结论 辐射诱导小鼠肺组织中MMP-2和MMP-9的表达增加,可能加剧了急性放射性肺损伤.

  15. Fenyves, Katalin: "Képzelt asszimiláció? Négy zsidó értelmiségi nemzedék önképe" [Imagined Assimilation? The Self-Representation of Four Generations of Jewish Intellectuals

    Directory of Open Access Journals (Sweden)

    Mary Gluck

    2011-01-01

    Full Text Available Fenyves, Katalin. Képzelt asszimiláció? Négy zsidó értelmiségi nemzedék önképe[Imagined Assimilation? The Self-Representation of Four Generations of Jewish Intellectuals]. Budapest: Corvina, 2010. 299 pp., illus. Reviewed by Mary Gluck, Brown University.

  16. 人参皂苷和丹参注射液对犬食管大剂量辐射损伤的影响%Effects of Ginsenosides and Salviae Miltiorrhizae on Canine Esophagus after Intrathoracic 20 Gy Electron Beam Radiation

    Institute of Scientific and Technical Information of China (English)

    丁保国; 朱桂; 孙玉鹗; 赵海潞; 林善文

    2012-01-01

    Objectives \\ To observe the effects of Ginsenosides and Salviae Miltiorrhizae on canine esophagus after in-trathoracic 20 Gy electron beam radiation. Methods: 12 healthy mongrel dogs were randomly divided into three groups with 4 in each group. A single dose of 20Gy electronic beam radiation was given to the mid segment of the esophagus. Before the intrathoracic radiation, Ginsenosides solution (25mg/kg body weight) was injected intra-peritoneally 6 hours and 30 minutes in one group and Salviae Miltiorrhizae administered intravenously in the same manner in the second group and the third group received no medications. The dogs were sacrificed on 15th day after the radiation for pathological ex-amination. Results; Dogs in control group showed delayed recovery, body weight changed from (17.4 ±0. 7)kg to (14.4 ±0.7)kg on day 14, LDF value from 52.4 ±11. 1 on day 0 to 64. 9 ±11.2 on day 3, 47.4 ±7.4 on day 14. CEC count changed from 0. 25 ± 0.5 on day 0 to 10 ± 1. 83 on day 14; blood vascular size 10μm, with surrounding scattered blood red cells. HE staining showed esophageal mucosa had erosion and blood congestion, microvasculature much dilat-ed. Electron microscopic examination found membranal organells swelling such as loss of parallel arrays of endoplasmic reticulum and vacuolation and loss of ribosomal particles, swelling of mitochondria, phagosomes containing membranous structures. Ginsenosides group showed that bodyweight from 17. 3 ±0. 8kg on day 0 to 18. 4 ± 0. 6kg on day 14, LDF val-ue 50. 1 ±10.5 on day 0, 45.6 ±5.7 on day 3, 47.4 ±7.4 on day 14, CEC count 0. 25 ±0.5 on day 0, 3 ±0.96 on day 14, vascular size 4 ~ 6μm on day 0, 8u,m on day 14. HE staining and electronic microscopic examination showed significantly less damage than control group. Salviae Miltiorrhizae showed similar changes as control group. Conclusion; Advance administration of Ginsenosides will significantly alleviate the damage of the esophagus receiving a single large

  17. A combination of high dose rate (10X FFF/2400 MU/min/10 MV X-rays) and total low dose (0.5 Gy) induces a higher rate of apoptosis in melanoma cells in vitro and superior preservation of normal melanocytes.

    Science.gov (United States)

    Sarojini, Sreeja; Pecora, Andrew; Milinovikj, Natasha; Barbiere, Joseph; Gupta, Saakshi; Hussain, Zeenathual M; Tuna, Mehmet; Jiang, Jennifer; Adrianzen, Laura; Jun, Jaewook; Catello, Laurice; Sanchez, Diana; Agarwal, Neha; Jeong, Stephanie; Jin, Youngjin; Remache, Yvonne; Goy, Andre; Ndlovu, Alois; Ingenito, Anthony; Suh, K Stephen

    2015-10-01

    The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition in combination with radiation to enhance apoptosis in melanoma cells. Cells irradiated using 10X flattening filter-free (FFF) 10 MV X-rays at a dose rate of 400 or 2400 MU/min and a total dose of 0.25-8 Gy were analyzed by cell/colony counting, MitoTracker, MTT, and DNA-damage assays, as well as by quantitative real-time reverse transcriptase PCR in the presence or absence of mitochondrial respiration inhibitors. A dose rate of 2400 MU/min killed on average five-fold more melanoma cells than a dose rate 400 MU/min at a total dose of 0.5 Gy and preserved 80% survival of HEM and 90% survival of HDF. Increased apoptosis at the 2400 MU/min dose rate is mediated by greater DNA damage, reduced cell proliferation, upregulation of apoptotic genes, and downregulation of cell cycle genes. HEM and HDF were relatively unharmed at 2400 MU/min. Radiation induced upregulation of mitochondrial respiration in both normal and cancer cells, and blocking the respiration with inhibitors enhanced apoptosis only in melanoma cells. A high dose rate with a low total dose (2400 MU/min, 0.5 Gy/10X FFF 10 MV X-rays) enhances radiosensitivity of melanoma cells while reducing radiotoxicity toward HEM and HDF. Selective cytotoxicity of melanoma cells is increased by blocking mitochondrial respiration.

  18. Pri tofuo/tohuo/toǔfuo kai soikazeo

    Institute of Scientific and Technical Information of China (English)

    AHN Song-san

    1997-01-01

    Manajoj el la t.n.sojfabo estas popularakaj gravaj en la orienta Azio,por inoj,japanojkaj koreoj.Science kaj praktike,la plantoj fabo kajsojfabo ne estas samaj legumenacaj specioj.Lavorto fabo(Vicia faba L.)estas uzata anka

  19. Julius Caesar and the Gallic Campaign: A Roadmap to the Use of the Instruments of Power

    Science.gov (United States)

    2010-03-30

    wine.16 ill contrast, the Belgae were exuberant consumers who constantly exhausted resources. The Belgae, also 1he quintessential egalitarians...or "Romanization," refers to Rome’s ethnocentric view that Rome was omnipotent and just; therefore, barbarians should be grateful for the

  20. Prezidenta Thetshni nenavideli i po etu storonu barrikadõ / Julius Stross

    Index Scriptorium Estoniae

    Stross, Julius

    2004-01-01

    Moskva-meelne president Ahmad Kadõrov oli vene ohvitseride seas ebapopulaarne esimese Tšetšeenia sõja (1994-1996) ajal toime pandu pärast. Kadõrov uskus, et Putini pakutav autonoomiapoliitika on ainuke võimalus edasi liikumiseks

  1. Julius Edgar Lilienfeld Prize Talk: Quantum spintronics: abandoning perfection for new technologies

    Science.gov (United States)

    Awschalom, David D.

    2015-03-01

    There is a growing interest in exploiting the quantum properties of electronic and nuclear spins for the manipulation and storage of information in the solid state. Such schemes offer qualitatively new scientific and technological opportunities by leveraging elements of standard electronics to precisely control coherent interactions between electrons, nuclei, and electromagnetic fields. We provide an overview of the field, including a discussion of temporally- and spatially-resolved magneto-optical measurements designed for probing local moment dynamics in electrically and magnetically doped semiconductor nanostructures. These early studies provided a surprising proof-of-concept that quantum spin states can be created and controlled with high-speed optoelectronic techniques. However, as electronic structures approach the atomic scale, small amounts of disorder begin to have outsized negative effects. An intriguing solution to this conundrum is emerging from recent efforts to embrace semiconductor defects themselves as a route towards quantum machines. Individual defects in carbon-based materials possess an electronic spin state that can be employed as a solid state quantum bit at and above room temperature. Developments at the frontier of this field include gigahertz coherent control, nanofabricated spin arrays, nuclear spin quantum memories, and nanometer-scale sensing. We will describe advances towards quantum information processing driven by both physics and materials science to explore electronic, photonic, and magnetic control of spin. Work supported by the AFOSR, ARO, DARPA, NSF, and ONR.

  2. Problems of implementation the total quality management in the Lithuanian road building enterprises / Julius Christauskas

    Index Scriptorium Estoniae

    Christauskas, Julius

    2005-01-01

    Leedu tee-ehitusettevõtete juhtimine ei ole suunatud protsessi kui terviku kontrollile ja tulemuslikule meeskonnatööle, töötajad ei ole valmis võtma suuremat vastutust, puudu jääb efektiivsusest, loovusest ja innovatiivsusest. Tabelid. Graafikud

  3. [Quo vadis cardiologia? Or: An nescis, mi fili, quantilla prudentia mundus regatur? (Pope Julius III)].

    Science.gov (United States)

    Kübler, W

    2003-02-01

    In order to recognize and to solve problems, a look in the future is essential despite many uncertainties. Besides sound bed side-teaching, the main aim in the education of the students should be to acquire self-responsiveness and an attitude of permanent learning. It is more than doubtful whether the high expectations of health politicians will be met to limit the cost of in-patient treatment by introducing diagnosis-related groups in combination with evidence-based medicine, as this method has several severe limitations in order to fulfill this duty. The new financial system based on diagnosis-related groups will be in favor of private investors compared to the government-dependent university hospitals. The changing population pyramid implies not only higher costs but in addition severe medical problems. Within the changing society, alterations in the patient's behavior are to be expected. Several factors will contribute to make the doctor's profession less attractive. In the developing countries a rapid increase in the non-communicative diseases, i.e., in coronary heart disease, has to be expected. Apart from the prolongation of life - especially during its terminal phase - it is mainly the allocation of resources between industrialized and developing countries which will determine the ethical discussion. Germany has lost its leading position of the 19th and beginning of the 20th century in medical sciences. This was based on the liberal university system introduced by Wilhelm von Humboldt. Several pioneering innovations of German cardiologists during the 20th century have not strengthened German industry - in contrast to the situation in the 19th century. The general conditions in Germany, which are not research oriented, have prompted the majority of the pharmaceutical firms to transfer their research activities into foreign countries. In addition Germany's cardiological research has lost basic sciences partners for clinically orientated basic research, as many institutes which formerly worked in the cardiovascular field, are now devoted to other specialties. Restrictive legal regulations--such as the law regulating working hours, anti-corruption laws and the new legal university framework--are not conducive to internationally competitive research. Creative and innovative research requires liberal general conditions and cannot be planed.

  4. Julius Edgar Lilienfeld Prize: The RG and me: love at first bite

    Science.gov (United States)

    Shankar, Ramamurti

    2009-03-01

    From the time I took the first bite out of that cut-off, I have been in love with the Renormalization Group, returning to it over and over again to apply it to classical and quantum problems, in clean as well as disordered systems. This talk, aimed at non-experts, introduces and illustrates the RG ideas, with a favorite application, understanding Landau's Fermi liquid.

  5. Prezidenta Thetshni nenavideli i po etu storonu barrikadõ / Julius Stross

    Index Scriptorium Estoniae

    Stross, Julius

    2004-01-01

    Moskva-meelne president Ahmad Kadõrov oli vene ohvitseride seas ebapopulaarne esimese Tšetšeenia sõja (1994-1996) ajal toime pandu pärast. Kadõrov uskus, et Putini pakutav autonoomiapoliitika on ainuke võimalus edasi liikumiseks

  6. Julius Edgar Lilienfeld Prize Lecture: Mapping the Universe: Physics Writ Large

    Science.gov (United States)

    Geller, Margaret

    2013-03-01

    The age of mapping the universe began in earnest in the late twentieth century. I will describe the enormous strides we have made in mapping the galaxy distribution and in understanding its nature and history. I will show how techniques for measuring the (primarily dark) matter distribuion in massive systems of galaxies are an astrophysical route to tests of fundamental physics.

  7. Julius Edgar Lilienfeld Prize: Chaotic Dynamics in the Physical Sciences: Some Comments and Examples

    Science.gov (United States)

    Ott, Edward

    2014-03-01

    Chaos was first discovered by Poincare in his famous 1887 work on the motion of N >2 bodies interacting through gravitational attraction. Although steady progress was made by mathematicians following Poincare's work, widespread impact and development of chaos in the physical sciences is only comparatively recent, i.e., approximately starting in the 1970's. This talk will review this history and give some examples illustrating the types of questions, problems and results arising from perspectives resulting from widespread participation of physical scientists.

  8. Problems of implementation the total quality management in the Lithuanian road building enterprises / Julius Christauskas

    Index Scriptorium Estoniae

    Christauskas, Julius

    2005-01-01

    Leedu tee-ehitusettevõtete juhtimine ei ole suunatud protsessi kui terviku kontrollile ja tulemuslikule meeskonnatööle, töötajad ei ole valmis võtma suuremat vastutust, puudu jääb efektiivsusest, loovusest ja innovatiivsusest. Tabelid. Graafikud

  9. EPIDEMIOL O GY OF CHIKUNGUNYA FEVER IN SRIKAKULAM DISTRICT

    Directory of Open Access Journals (Sweden)

    Arunasree

    2015-05-01

    Full Text Available BACKGROUND : Chikungunya fever is a self - limiting viral fever spread by mosquito bite and has become an epidemic. The proportion of cases has increased in Andhra Pradesh. We report a prospective analysis of cases of c hikungunya fever referred from various primary health centers of rural, tribal and semiurban areas of Srikakulam district, Andhra Pradesh. AIMS OF STUDY: To analyse the burden of C hikungunya fever in the Srikakulam district of Andhra Pradesh . MATERIAL AND METHODS : A prospective descriptive study was under taken between January - 2013 to December - 2014 by testing clinically suspected c hikungunya fever patients attending tertiary care centre in the Srikakulam district, Andhra Pradesh. The blood collected from suspected patients was analyzed for CHIK specific IgM antibodies by ELISA method using Nivchik kit. The data was recorded and analyzed. RESULTS: During the study period the total number of samples screened with clinical suspicion of c hikungunya fever was 127, out of which 23(18.11% were positive for IgM antibodies. The number of seropositive cases referred from rural area was 3 in number and from tribal areas 20. The seasonal distribution of cases was variable. CONCLUSION: Chikungunya fever is self limiting disease . Efforts have to be made through community awareness and early institution of supportive therapy. Vector control measures should be in full swing

  10. GY SAMPLING THEORY IN ENVIRONMENTAL STUDIES 2: SUBSAMPLING ERROR MEASUREMENTS

    Science.gov (United States)

    Sampling can be a significant source of error in the measurement process. The characterization and cleanup of hazardous waste sites require data that meet site-specific levels of acceptable quality if scientifically supportable decisions are to be made. In support of this effort,...

  11. The effects of G-CSF combined with SB203580 on the immune system of mice received 4 Gy total body irradiation%G-CSF联合SB203580对4Gy照射小鼠免疫系统的作用

    Institute of Scientific and Technical Information of China (English)

    李德冠; 路璐; 吴红英; 张俊伶; 孟爱民

    2014-01-01

    Objective To observe the effects of G-CSF combined with SB203580(SB) on the immune system of mice received 4 Gy total body irradiation (TBI).Methods Thirty male C57BL/6 mice were randomly divided into control group,irradiated group,combined group.The mice in irradiated and combined group received 4 Gy TBI.In combined group,G-CSF (1 μg/each) was intraperitoneally (ip) injected twice one day for 5 days,SB (15 mg/kg) was ip injected every other day after 4 Gy TBI for 5 times.After 4 Gy TBI 10 days,the peripheral bloods were counted,the CD4,CD8,B220 cells in WBC and CD4,CD8 in thymocytes were analyzed by flowcytometry.The reactive oxygen species levels (ROS) of bone marrow cells were detected by microplate reader.Results Compared to the control group,the proportion of CD8,B220 and WBC in the irradiated mice significantly decreased,CD4+CD8+ thymocytes and ROS levels of bone marrow cells increased significantly.Compared to irradiation group,red blood,platelet,CD4 and CD8 cells in peripheral blood,CD4+CD8+ thymocytes decreased in the combined group.Conclusion G-CSF combined with SB has protective effects on the radiation-induced injury in immune system.%目的 研究G-CSF联合p38抑制剂SB203580 (SB)对免疫细胞辐射损伤的作用.方法 C57BL/6雄性小鼠按体质量随机分为对照组、照射组和给药组.照射组和给药组给予4 Gy全身照射.给药组小鼠给予腹腔注射G-CSF和SB,G-CSF于4Gy照射后2h和6h给药(1μg/只),每天2次,连续给药5d,SB于照射后24h给药(15 mg/kg),隔日给药,共给药5次.照射后10d测外周血计数,进行白细胞CD4、CD8、B220检测、胸腺细胞CD4、CD8检测和骨髓细胞活性氧检测.结果 照射组外周血计数和CD8、B220比例下降,而胸腺细胞中CD4+CD8+细胞比例及骨髓细胞活性氧水平显著增加.与照射组相比,联合给药组外周血红细胞数、血小板、CD4、CD8细胞比例升高,胸腺细胞中CD4+CD8+细胞比例下降.结论 G-CSF联合SB对4 Gy照射

  12. Pulmonary Toxicity in Stage III Non-Small Cell Lung Cancer Patients Treated With High-Dose (74 Gy) 3-Dimensional Conformal Thoracic Radiotherapy and Concurrent Chemotherapy Following Induction Chemotherapy: A Secondary Analysis of Cancer and Leukemia Group B (CALGB) Trial 30105

    Energy Technology Data Exchange (ETDEWEB)

    Salama, Joseph K., E-mail: joseph.salama@duke.edu [Duke University Medical Center, Durham, NC (United States); Stinchcombe, Thomas E. [University of North Carolina at Chapel Hill, Chapel Hill, NC (United States); Gu Lin; Wang Xiaofei [CALGB Statistical Center, Duke University Medical Center, Durham, NC (United States); Morano, Karen [Quality Assurance Review Center, Lincoln, RI (United States); Bogart, Jeffrey A. [State University of New York Upstate Medical University, Syracuse, NY (United States); Crawford, Jeffrey C. [Duke University Medical Center, Durham, NC (United States); Socinski, Mark A. [University of North Carolina at Chapel Hill, Chapel Hill, NC (United States); Blackstock, A. William [Wake Forest University School of Medicine, Winston-Salem, NC (United States); Vokes, Everett E. [University of Chicago, Chicago, IL (United States)

    2011-11-15

    Purpose: Cancer and Leukemia Group B (CALGB) 30105 tested two different concurrent chemoradiotherapy platforms with high-dose (74 Gy) three-dimensional conformal radiotherapy (3D-CRT) after two cycles of induction chemotherapy for Stage IIIA/IIIB non-small cell lung cancer (NSCLC) patients to determine if either could achieve a primary endpoint of >18-month median survival. Final results of 30105 demonstrated that induction carboplatin and gemcitabine and concurrent gemcitabine 3D-CRT was not feasible because of treatment-related toxicity. However, induction and concurrent carboplatin/paclitaxel with 74 Gy 3D-CRT had a median survival of 24 months, and is the basis for the experimental arm in CALGB 30610/RTOG 0617/N0628. We conducted a secondary analysis of all patients to determine predictors of treatment-related pulmonary toxicity. Methods and Materials: Patient, tumor, and treatment-related variables were analyzed to determine their relation with treatment-related pulmonary toxicity. Results: Older age, higher N stage, larger planning target volume (PTV)1, smaller total lung volume/PTV1 ratio, larger V20, and larger mean lung dose were associated with increasing pulmonary toxicity on univariate analysis. Multivariate analysis confirmed that V20 and nodal stage as well as treatment with concurrent gemcitabine were associated with treatment-related toxicity. A high-risk group comprising patients with N3 disease and V20 >38% was associated with 80% of Grades 3-5 pulmonary toxicity cases. Conclusions: Elevated V20 and N3 disease status are important predictors of treatment related pulmonary toxicity in patients treated with high-dose 3D-CRT and concurrent chemotherapy. Further studies may use these metrics in considering patients for these treatments.

  13. 60Coγ射线2.0 Gy剂量诱导大鼠淋巴细胞基因表达的改变%Study of Differential Gene Expression Profiling in Peripheral Blood Lymphocyte of Rat with 2 .0 Gy Gamma Ray Irradiation

    Institute of Scientific and Technical Information of China (English)

    李建国; 尹晶晶; 秦秀军; 张伟; 周晋源; 闻建华

    2013-01-01

    利用Agilent Rat全基因组芯片技术和实时荧光定量PCR技术,采用60 Coγ射线对SD大鼠全身照射,照射剂量为2.0 Gy ,分析照后6、12、24小时大鼠外周血淋巴细胞的差异表达基因谱和通路,同时对基因芯片结果进行验证。结果表明:(1)照后6小时,差异表达基因有1084个,其中上调的736个,下调的348个;照后12小时,差异表达基因有2590个,其中上调的1621个,下调的969个;照后24小时,差异表达基因有3938个,其中上调的2278个,下调的1660个;3个时间点共同差异表达基因有446个,其中上调的274个,下调的172个。(2)照后6小时,差异表达基因涉及到的通路有18个;照后12小时,差异表达基因涉及到的通路有35个;照后24小时,差异表达基因涉及到的通路有38个。其中通路Cell adhesion molecules、Toxoplasmosis、B cell receptor signaling、Intestinal immune network for IgA Production等在照后3个时间点均有出现。(3)差异表达基因Trmt61a和Enc1的相对定量结果与基因芯片检验结果表达趋势一致。%The study analyzed the differential expression profile and pathway of peripheral blood lymphocyte in SD rats 6 ,12 and 24 hours after irradiation to 2 .0 Gy gamma ray .The results showed that at 6 hours after ir-radiation there were 1084 differentially expressed genes of which 736 genes were up-regulated and 348 genes down-regulated .12 hours after irradiation there were 2590 differentially expressed genes of which 1621 genes were up-regulated and 969 genes down-regulated .24 hours after irradiation there were 3938 differentially ex-pressed genes of which 2278 genes were up-regulated and 1660 genes down-regulated .There were 446 co-ex-pressed differential genes at three time points ,of which 274 genes were up-regulated and 172 genes down-regu-lated .The KEGG analysis revealed that 6h point 18 pathways ,12 hours point 35 pathways ,and 24 hours point

  14. High Dose Granulocyte Colony-Stimulating Factor Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated by 2.3 Gy Mixed Fission Neutron and Gamma Ray%大剂量粒细胞集落刺激因子对2.3Gy中子γ射线混合照射比格犬存活和造血重建的影响

    Institute of Scientific and Technical Information of China (English)

    李明; 柳晓兰; 赵振虎; 王欣茹; 从玉文; 罗庆良; 余祖胤; 邢爽; 欧红玲; 熊国林; 谢玲; 赵燕芳; 韩阿如娜; 善亚君

    2011-01-01

    This study was purposed to evaluate the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF)on hematopoietic reconstruction and survival in beagles exposed to mixed fission neutron and γ-ray.13 beagles were unilaterally exposed to single dose of 2.3 Gy 90% neutrons.The experiments were divided into 3 groups:irradiation control group(no any treatment,n=4),supportive care group(n=5)and rhG-CSF plus supportive care group(n=4,abbreviated as rhG-CSF group)in which the beagles were subcutaneously injected with 200 μg/kg of rhG-CSF early at half an hour and 24 hours post-irradiation respectively.The results showed that 2.3 Gy 90% neutron irradiation induced a severe acute radiation sickness of bone marrow type.The administration of rhG-CSF increased the survival rate from 60% in supportive care group to 100%.Twice injection of rhG-CSF in the first 24 hours reduced duration of neutropenia,enhanced neutrophil nadir and promoted neutrophil recovery when compared with control cohort administered clinical support.The number of colony-forming cells(CFU-GM,CFU-E,and BFU-E)in peripheral blood of rhG-CSF treated canines increased 2-to 5-fold relative to those of the supportive care group on day 3.All canines treated with rhG-CSF achieved hematopoietic reconstruction as evidenced by the pathological section of sternum while severe shortage of hemopoietic cells remained in the cohorts given supportive care alone.It is concluded that the combination of supportive care and high-dose rhG-CSF can accelerate hematopoietic recovery and enhance survival of dogs exposed to 2.3 Gy mixed neutron and gamma ray

  15. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Branscome Julius Inc - Chriscott Supply)

    Science.gov (United States)

    1993-01-01

    LL M Mn AULA oLALALALAWW0WfL A LAWII* n~LntLAWOLAUmLAiflLALA LAWWLA WIALAWLALA it I (0-4ŕ ifI -4-1-4 _q4 -1 -f -4 -1- -4 -4 -4 .- f ’ -4 ’ -4 -.4. -4...cc M tic o 0 C113 ɛ -4 11 Z)0000anionoon => u C) 0 U u (-) C) 0 :D (-) D C) D C) (.) = 0 D a : uj I m C, -- 4 It m 0 o v Cp 0 o 0 Cý 0 C> o 00 cr) 0...Z -4O0 C -- 0 MC C O C 4 0 C 00 OC- ccN wm0’)- a0CC- C0 2 2 C- "c) CD(I.- 2 O) CC 0) C 030N 14zCC .20 <>Z 0z 02 tic CX 0.1 z 2 2 00 0 Wcoc CC E C

  16. Julius Edgar Lilienfeld Prize Talk: The Fermi Pasta Ulam (FPU) Problem and The Birth of Nonlinear Science

    Science.gov (United States)

    Campbell, David K.

    2010-03-01

    In 1953, Enrico Fermi, John Pasta, and Stan Ulam initiated a series of computer studies aimed at exploring how simple, multi-degree of freedom nonlinear mechanical systems obeying reversible deterministic dynamics evolve in time to an equilibrium state describable by statistical mechanics. Their expectation was that this would occur by mixing behavior among the many linear modes. Their intention was then to study more complex nonlinear systems, with the hope of modeling turbulence computationally. The results of this first study of the so-called Fermi-Pasta-Ulam (FPU) problem, which were published in 1955 and characterized by Fermi as a ``little discovery,'' showed instead of the expected mixing of linear modes a striking series of (near) recurrences of the initial state and no evidence of equipartition. This work heralded the beginning of both computational physics and (modern) nonlinear science. In particular, the work marked the first systematic study of a nonlinear system by digital computers (``experimental mathematics'') and led directly to the discovery of ``solitons,'' as well as to deep insights into deterministic chaos and statistical mechanics. In this talk, I will review the original FPU studies and show how they led to the understanding of two key paradigms of nonlinear science. Specifically, I will show how a continuum approximation to the original discrete system led to the discovery of ``solitions'' whereas a low-mode approximation led to an early example of ``deterministic chaos.'' I will close with a brief indication of how the recurrence phenomenon observed by behavior by FPU can be reconciled with mixing, equipartition, and statistical mechanics.

  17. Fresh old news from Ferenczi about the function of dreams: the dream as a Kur, as a treatment and as a Gyógyászat.

    Science.gov (United States)

    Canesin Dal Molin, Eugênio

    2012-10-01

    This article discusses a text on the function of dreams and their relation to trauma. Ferenczi intended to present this material as a talk at the 12th International Congress of Psychoanalysis, which was to take place in Interlaken, Switzerland the same year that he wrote it (1931). The entire conference, however, was postponed, and parts of this communication's content appeared in other texts in which Ferenczi rethinks the concept of trauma and its clinical significance. In the present article the author makes use of the Freud/Ferenczi correspondence to contextualize Freud's Hungarian follower's originality regarding his theorizations about different aspects of the function of dreams. In the 1931 speech, as well as in this article, Ferenczi used a patient's dream work as a clinical example of a process in which traumatic experiences and unmastered sensory impressions can be repeated to achieve a better working-through for the dreamer. The process Ferenczi describes resembles an effort of self-treatment, of self-Kur.

  18. A randomized phase II trial of concurrent chemo-RT of oral vinorelbine and 60 Gy or 66 Gy, in locally advanced NSCLC

    DEFF Research Database (Denmark)

    Hansen, O.; Knap, M.; Khalil, A.

    2015-01-01

    Purpose/Objective: Concurrent chemo-radiation (CRT) is the treatment of choice for local advanced NSCLC patients. Despite the curative intent of the treatment, survival is poor with a median survival of about 16-18 months (m) and a 5 year (y) survival of 15%. The loco-regional control rate at 2 y...

  19. Preoperative short-term radiation therapy (25 Gy, 2.5 Gy twice daily) for primary resectable rectal cancer (phase II)

    NARCIS (Netherlands)

    Widder, J; Herbst, F; Dobrowsky, W; Schmid, R; Pokrajac, B; Jech, B; Chiari, C; Stift, A; Maier, A; Karner-Hanusch, J; Teleky, B; Wrba, F; Jakesz, R; Poetter, R

    2005-01-01

    To evaluate the feasibility, effectiveness, and long-term bowel function of preoperative hyperfractionated accelerated radiotherapy in primary resectable rectal cancer. A total of 184 consecutive patients ( median age 65 years, male : female = 2 : 1) with clinical T3Nx rectal adenocarcinoma received

  20. Study on English MOOC in Vocational Colleges from Educational Ecolo-gy Theory

    Institute of Scientific and Technical Information of China (English)

    封娇

    2015-01-01

    From the programmed instruction method in the 1960s and 1970s to the emergence of open courses at the beginning of the 21st century and then to the fast growth of massive open online course(MOOC),online education never stops its pace on the road of research and practice with the continuous upgrade of the Internet.As the hot education revolutionary,MOOC has aroused a large number of researchers'attention.So how English MOOC develop in vocational colleges? Is there any education theory contributing to MOOC's development? What's the special MOOC mode for English in vocational colleges? These are the research topics of this thesis.

  1. c Intes compo on die stine h osition ets wit istolog of Nile th both gy ...

    African Journals Online (AJOL)

    SAM

    400 to 800 mg/kg of an anti-nutritional factor called gossypol (Gatlin et al., 2007) which ... of Nile tilapia without negative effects on growth and feed utilization. For SFSC ..... Hu CH, Xu Y, Xia MS, Xiong L, Xu ZR (2007). Performance, microbial.

  2. O lirismo em György Lukács

    Directory of Open Access Journals (Sweden)

    Arlenice Almeida da Silva

    2009-06-01

    Full Text Available O artigo visa a examinar o tratamento dado ao lírico na obra estética do jovem Lukács. Em A alma e as formas o autor examina a poesia de Stefan George, encontrando nela elementos formais que apontam para o surgimento de um novo lirismo. Tal "forma significativa" possibilita ao autor introduzir uma abordagem do conceito de modernidade, em viés crítico e fenomenológico. Empreendimento que será completado em A teoria do romance, quando a tendência lírica se apresentará exacerbada, contaminando e alterando as configurações dos demais gêneros.The paper aims to examine the treatment of lyrical in the aesthetics work of the young Lukács. In The Soul and the Forms the author examines the poetry of Stefan George, finding on it formal elements that point out to the emergence of a new lyricism. This "significant form" allows the author to introduce an approach of the concept of modernity, in critical and phenomenological bias. Work that will be completed in The theory of Love, when the lyric trend will be exacerbated, contaminating and altering the settings of the other genera.

  3. Consumer Behaviour T oward Information Technolo gy Adoption on 3G Mobile Phone Usage in India

    Directory of Open Access Journals (Sweden)

    MANIVANNAN SENTHIL VELMURUGAN

    2014-12-01

    Full Text Available Mobile phones have grown to be the most widely used portable device in the world. Mobile phones’ usage is rapid growth to the public in India. Moreover, the understanding of the people toward adoption of information technology in 3G mobile phones’ usage shows relatively low in India. So, it is vital to find out the exact situation among consumers’ behavior on 3G mobile phones. This study investigates consumers’ awareness and perceived ease of use and their influence of information technology adoption in 3G mobile phones. The resultsshow that the two hypotheses are valid. Based upon the research findings, implication, limitations and suggestionsresearch are drawn, which include a proposition of a way forward in addressing the consumers’ adoption on information technology toward 3G mobile phones’ usages in India.

  4. Gamma Radiation (5-10 Gy) Impairs Neuronal Function in the Guinea Pig Hippocampus

    Science.gov (United States)

    1993-01-01

    Dosimetric measurements were made in accordance with the Ameri- can Association of Physicists in Medicine ( AAPM ) protocol for the deter- aff•o•u...Radial. Res. 70, 378-390 (1977). 20. American Association of Physicists in Medicine. AAPM Task Group I. G. H. Anno. S. J. Baum. H. R. Withers, and R...O’vygen (A. P. Autor, Ed.), pp. 127- 155 . Academic 40. A. J. van der Kogel. Central nervous system radiation injury in small Press, New York. 1982

  5. Growt var. h, phy Punch ysiolog h as af gy and ffected hy flower d by ...

    African Journals Online (AJOL)

    SAM

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  6. The Effects of Gx, Gy and Gz Forces on Cone Mesopic Vision

    Science.gov (United States)

    1983-10-01

    ON CONE TECHNICAL REPORT ,ESOP1C VISION 6. PERFORMING O1G. REPORT NUMBER 7. 4𔃾J~tq04) S. CONTRACT OR GRANT NUMBER(#) David A. Timpton "PE #RFORMING...Interesting qursticr. However, to tell whe𔃺v!r any diffrences noted wLre teuly due to weailug glasses. or merply to itiividual variations woulU requdr. mucl ...three hundred and sixtieth of a circle. miotics - Drugs which cause contraction of the pupil. mydriatics - Drugs which cause dilitation of the rupil

  7. PERSPECTIVES FROM POSITIVE PSYCHOLO GY IN OLDER ADULTS: BRIEF LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Nathália Brandolim Becker

    2016-03-01

    Full Text Available The present review aims to determine the main findings concerning positive psychology in older adults. We used the electronic databases Web of Science and EBSCO, which were efficient tools to find the necessary heterogeneity for the selection of studies published between 2005 and 2015, through the following keywords: “Positive Psychology” and “Older”. After selecting 12 studies, they were assessed regarding the following information: (a source; (b setting; (c number of older adults (participants; (d average age (SD; (e inclusion criteria for each study; (f instruments; and (g the results of our investigative question. The results show that interventions with a positive psychology approach are favorable to the reduction of symptoms (anxiety and depression and the increase of wellbeing; and positive psychology constructs have the same impact on well-being and on reducing symptoms, portraying a promising approach to public health. Our investigation showed the necessity to develop a new perspective on aging. Some of the assessed studies reported that it is possible to achieve this with the inclusion of positive psychology, which can facilitate this development.

  8. SPONGY (SPam ONtoloGY): email classification using two-level dynamic ontology.

    Science.gov (United States)

    Youn, Seongwook

    2014-01-01

    Email is one of common communication methods between people on the Internet. However, the increase of email misuse/abuse has resulted in an increasing volume of spam emails over recent years. An experimental system has been designed and implemented with the hypothesis that this method would outperform existing techniques, and the experimental results showed that indeed the proposed ontology-based approach improves spam filtering accuracy significantly. In this paper, two levels of ontology spam filters were implemented: a first level global ontology filter and a second level user-customized ontology filter. The use of the global ontology filter showed about 91% of spam filtered, which is comparable with other methods. The user-customized ontology filter was created based on the specific user's background as well as the filtering mechanism used in the global ontology filter creation. The main contributions of the paper are (1) to introduce an ontology-based multilevel filtering technique that uses both a global ontology and an individual filter for each user to increase spam filtering accuracy and (2) to create a spam filter in the form of ontology, which is user-customized, scalable, and modularized, so that it can be embedded to many other systems for better performance.

  9. Julius J. Bautista (2010. Figuring Catholicism: An ethnohistory of the Santo Niño de Cebu. Quezon City: Ateneo de Manila University.

    Directory of Open Access Journals (Sweden)

    Yeoh Seng Guan

    2011-12-01

    Full Text Available Let me begin with a confession—I am a novice to Philippines Studies.However, long before stepping foot in the Philippines (in 2006, I have beenintrigued by the seemingly pervasive presence of Roman Catholicism in party politics, popular culture and the everyday religiosity of Philippine society as gleaned through my sporadic forays into Filipino scholarly literature (and movies from afar.

  10. [Introduction and transformation of the psychiatric term "anancasm". From Gyula (Julius) Donáth via Kurt Schneider to ICD-10].

    Science.gov (United States)

    Steinberg, H

    2014-09-01

    The conceptual history of "anancasm" in psychiatry remains almost unexplored and this article will help to remove this deficit. It was the Budapest-based neuropsychiatrist Gyula Donáth (1849-1944) who first proposed this Greek-rooted term in 1897 as an international term for compulsive symptoms and as an independent mental illness similar to present-day obsessive compulsive disorders (ICD-10). By suggesting this term Donáth wanted to extend the concept of compulsion as proposed by his teacher Carl Westphal to other compulsive phenomena, psychomotor impulses and restrictions including echolalia, coprolalia, echokinesis, echopraxia, contemporary maladie des tics (present day Tourette's syndrome) and even intermittent dipsomania (craving for alcohol), paraphilias, sexual fetishes and homosexuality. In 1923 Kurt Schneider used this term for a subgroup of psychopathic personalities, the so-called insecure anancastic psychopaths. His concept was much different to that suggested by Donáth, with the only thing in common being the compulsory component. Schneider's anancasts suffered from feelings of insecurity and insufficiency and were forced to try to overcompensate by being excessively careful, meticulous and hyper-correct. Based on Schneider's concept anancasm has survived as a name for a subdivision of compulsive personality disorders in ICD-10; however, these rather complex personality defects were not what Donáth had in mind when he first suggested the term anancasm. The paper discusses further discrepancies between Donáth, Schneider and ICD-10.

  11. Take it or leave it

    DEFF Research Database (Denmark)

    With texts from Christine van Assche, Heather Barton, Hans Belting, Raymond Bellour, Dan Cameron, Sabine Fabo, Solange Farkas, Ursula Frohne, Jörg Heiser, Wulf Herzogenrath, Kathy Rae Huffman, Slavko Kacunko, Doris Krystof, Friedemann Malsch, Kobena Mercer, Yvonne Spielmann, Paul Virilio Marcel O...

  12. A randomized phase II trial of concurrent chemoradiation with two doses of radiotherapy, 60Gy and 66Gy, concomitant with a fixed dose of oral vinorelbine in locally advanced NSCLC

    DEFF Research Database (Denmark)

    Hansen, Olfred; Knap, Marianne; Khalil, Azza Ahmed

    2017-01-01

    Introduction: In order to test the best performing radiation dose with a convenient chemotherapy schedule of an oral formulation of radio-sensitizing vinorelbine in inoperable locally advanced non-small cell lung cancer (NSCLC), we performed a randomized phase II trial based on a "pick the winner...

  13. O símbolo esvaziado: a teoria do romance do jovem György Lukács The emptied symbol: young György Lukács's Theory of the Romance

    Directory of Open Access Journals (Sweden)

    Arlenice Almeida da Silva

    2006-01-01

    Full Text Available O presente artigo investiga como A teoria do romance (1916 de G. Lukács, um texto fragmentado e de ocasião, tornou-se um clássico da reflexão sobre a modernidade. Para Lukács, o romance é a forma artística que corresponde à fratura entre o sujeito e o mundo, vivida pelo homem contemporâneo. Utilizando o conceito de "símbolo esvaziado" este texto apreende em que medida o autor ao rever as classificações anteriores sobre o gênero romance, perpetua a tradição romântica ou rompe com ela, elaborando conceitos originais para a compreensão da modernidade na literatura.The present article investigates how G. Lukács's Theory of the romance (1916, a fragmented and of occasion text, became a classic of the reflection on modernity. For Lukács, the novel is the correspondent artistic form to the fracture between the subject and the world, lived by the contemporary man. Using the concept of "emptied symbol" this text apprehends how far the author, when reviewing the previous classifications on the genre of novel, perpetuates the romantic tradition or breaks it, elaborating original concepts for the understanding of modernity in literature.

  14. ‘Als gy maar schérp wordt, zo zyn wy, én gy voldaan.’ Rationalistische ideeën van het kunstgenootschap Nil Volentibus Arduum 1669-1680

    NARCIS (Netherlands)

    Holzhey, T.

    2014-01-01

    Dit proefschrift analyseert de activiteiten en werken van het Amsterdamse kunstgenootschap Nil Volentibus Arduum (Waar een wil is, is een weg) gedurende de eerste tien jaar van zijn bestaan, tegen de achtergrond van het rationalisme. Meerdere oprichtingsleden hingen de opvattingen van rationalistisc

  15. Gyöngyi Szabó Földesi as Scientist and University Teacher in Hungarian and International Perspective

    Directory of Open Access Journals (Sweden)

    Földesi Gyöngyi Szabó

    2017-03-01

    Full Text Available This is the third article of the cycle of portraits of the members of the Editorial Board and Editorial Advisory Board of the journal Physical Culture and Sport. Studies and Research, who are eminent social scientists researching the issue of sport. Among them, there are many world-class professors, rectors and deans of excellent universities, founders, presidents and secretaries-general of continental and international scientific societies and editors of high-scoring journals related to social sciences focusing on sport. The journal Physical Culture and Sport. Studies and Research started its activities in 2008 and gathered many readers, distinguished authors and outstanding reviewers. It is worth taking a moment to present the profiles of the individual editors, thanks to whom the journal keeps getting better and better. The journal is increasingly appreciated internationally particular among the scientists from the humanist and social areas of investigations. The rapidly increasing number of its readers and its surprisingly wide reception, indicated by the number of visits and downloads in English-speaking countries, including hundreds of universities (up to 791 were interested in the content of issue 62 of our magazine, research institutes and related libraries, as well as academics, researchers and students, should be celebrated. These data are derived only from one bibliographic data base (EBSCO. It must be noted that the journal is indexed in 41 bases.

  16. Testing the West German model in East Germany and Hungary: the motor industry in Zwickau and Györ

    NARCIS (Netherlands)

    Keune, M.; Piotti, G.; Tóth, A.; Crouch, C.; Crouch, C.; Voelzkow, H.

    2009-01-01

    This chapter considers the development of two car-manufacturing plants, both of the VW-Audi group, in two areas that had been parts of the former Soviet bloc: Zwickau and Gyr. There appears to be a major difference between the two, in that Zwickau is in the former German Democratic Republic and

  17. Testing the West German model in East Germany and Hungary: the motor industry in Zwickau and Györ

    NARCIS (Netherlands)

    M. Keune; G. Piotti; A. Tóth; C. Crouch

    2009-01-01

    This chapter considers the development of two car-manufacturing plants, both of the VW-Audi group, in two areas that had been parts of the former Soviet bloc: Zwickau and Gyr. There appears to be a major difference between the two, in that Zwickau is in the former German Democratic Republic and ther

  18. [Research work in the Department of Pharmaceutical Technology of the Albert Szent-Györgyi Medical University].

    Science.gov (United States)

    Selmeczi, B

    1993-05-01

    A short review is given of the research carried out in recent years in the Department of Pharmaceutical Technology headed by the author on the occasion of the 75th birthday of Professor Károly Nikolics. The main results of the scientific activities performed in the four research groups are reported and a few important references to literature are made.

  19. WORKSHOP REPORT: MOLECULAR & CELLULAR BIOLOGY OF MODERATE DOSE (1-10 GY) RADIATION & POTENTIAL MECHANISMS OF RADIATION PROTECTION

    Science.gov (United States)

    EXECUTIVE SUMMARYNormal tissue response and injury after exposure to ionizing radiation are of great importance to patients with cancer, populations potentially subjected to military, accidental or intentional exposure including bioterrorism, and workers in the nuclear po...

  20. Development of the EGGS "Exam of GeoloGy Standards" to Measure Students' Understanding of Common Geology Concepts

    Science.gov (United States)

    Guffey, Sarah Katie; Slater, Timothy F.; Slater, Stephanie J.

    2017-01-01

    Geoscience education researchers have considerable need for criterion-referenced, easy-to-administer, easy-to-score, conceptual surveys for undergraduates taking introductory science survey courses in order for faculty to monitor the learning impacts of innovative teaching. In response, this study establishes the reliability and validity of a…

  1. Testing the West German model in East Germany and Hungary: the motor industry in Zwickau and Györ

    NARCIS (Netherlands)

    Keune, M.; Piotti, G.; Tóth, A.; Crouch, C.; Crouch, C.; Voelzkow, H.

    2009-01-01

    This chapter considers the development of two car-manufacturing plants, both of the VW-Audi group, in two areas that had been parts of the former Soviet bloc: Zwickau and Gyr. There appears to be a major difference between the two, in that Zwickau is in the former German Democratic Republic and ther

  2. Assessment of Probable Future Land Use and Habitat Conditions in Water Resources Planning.

    Science.gov (United States)

    1982-12-01

    Carlisle and Park (1976); wastewater treatment facility c. Fabos, Green, and Joyner (1978); responsible regional landscape planning . d. Miller, Tom, and...relationships of alternative land uses on various landscape, ecological, and public service resources of prime concern in landscape planning . METLAND...uses is within the context of landscape planning . The description of future uses then is essentially that of the most suitable and desirable usage

  3. Muusikamaailm : Gergievi festival Rotterdamis. Los Angelese Ooper alustas. Luzerni festival tänaseni. Yaltah Menuhin lahkunud. Kyoto auhind György Ligetile / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Rotterdami Filharmoonikute peadirigendi V. Gergijevi korraldatud muusikafestivalist. Los Angelese Ooperi hooaja algusest. Luzerni festivalist šveitsis. Lühidalt Yaltah Menuhinist. G. Ligeti pälvis Kyoto elutöö-auhinna

  4. Paisaje tras la catástrofe: Adaptación y resiliencia al cambio cultural entre los Tibetanos de Gyêgu

    OpenAIRE

    Carralero Benítez, Santiago

    2015-01-01

    Esta investigación, en linea con otros trabajos que abordan dinámicas contemporáneas de comunidades indígenas complejas implicadas en dilatados procesos de integración estatal, se desarrolla en el escenario social proporcionado por la nacionalidad

  5. Phase 1/2 Trials of Temozolomide, Motexafin Gadolinium, and 60-Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme: Final Results of RTOG 0513

    Energy Technology Data Exchange (ETDEWEB)

    Brachman, David G., E-mail: david.brachman@dignityhealth.org [Arizona Oncology Services Foundation, Scottsdale, Arizona (United States); Barrow Neurological Institute, St. Joseph' s Hospital and Medical Center, Phoenix, Arizona (United States); Pugh, Stephanie L. [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Ashby, Lynn S. [Barrow Neurological Institute, St. Joseph' s Hospital and Medical Center, Phoenix, Arizona (United States); Thomas, Theresa A. [Arizona Oncology Services Foundation, Scottsdale, Arizona (United States); Dunbar, Erin M. [University of Florida College of Medicine, Gainesville, Florida (United States); Narayan, Samir [St. Joseph Mercy Hospital, Ann Arbor, Michigan (United States); Robins, H. Ian [University of Wisconsin Hospital, Madison, Wisconsin (United States); Bovi, Joseph A. [Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Rockhill, Jason K. [University of Washington Medical Center, Seattle, Washington (United States); Won, Minhee [Barrow Neurological Institute, St. Joseph' s Hospital and Medical Center, Phoenix, Arizona (United States); Curran, Walter P. [Emory University, Atlanta, Georgia (United States)

    2015-04-01

    Purpose: The purpose of phase 1 was to determine the maximum tolerated dose (MTD) of motexafin gadolinium (MGd) given concurrently with temozolomide (TMZ) and radiation therapy (RT) in patients with newly diagnosed supratentorial glioblastoma multiforme (GBM). Phase 2 determined whether this combination improved overall survival (OS) and progression-free survival (PFS) in GBM recursive partitioning analysis class III to V patients compared to therapies for recently published historical controls. Methods and Materials: Dose escalation in phase 1 progressed through 3 cohorts until 2 of 6 patients experienced dose-limiting toxicity or a dose of 5 mg/kg was reached. Once MTD was established, a 1-sided 1-sample log-rank test at significance level of .1 had 85% power to detect a median survival difference (13.69 vs 18.48 months) with 60 deaths over a 12-month accrual period and an additional 18 months of follow-up. OS and PFS were estimated using the Kaplan-Meier method. Results: In phase 1, 24 patients were enrolled. The MTD established was 5 mg/kg, given intravenously 5 days a week for the first 10 RT fractions, then 3 times a week for the duration of RT. The 7 patients enrolled in the third dose level and the 94 enrolled in phase 2 received this dose. Of these 101 patients, 87 were eligible and evaluable. Median survival time was 15.6 months (95% confidence interval [CI]: 12.9-17.6 months), not significantly different from that of the historical control (P=.36). Median PFS was 7.6 months (95% CI: 5.7-9.6 months). One patient (1%) experienced a grade 5 adverse event possibly related to therapy during the concurrent phase, and none experience toxicity during adjuvant TMZ therapy. Conclusions: Treatment was well tolerated, but median OS did not reach improvement specified by protocol compared to historical control, indicating that the combination of standard RT with TMZ and MGd did not achieve a significant survival advantage.

  6. High-dose radiotherapy (60 Gy) with oral UFT/folinic acid and escalating doses of oxaliplatin in patients with non-resectable locally advanced rectal cancer (LARC)

    DEFF Research Database (Denmark)

    Weber Vestermark, Lene; Jensen, Helle A; Pfeiffer, Per

    2012-01-01

    Consensus is that patients with locally advanced rectal cancer (LARC) should receive long-term chemoradiotherapy (CRT) before surgery. With the intent to offer the patients intensified concomitant chemotherapy (CT) to improve outcome and to assess tolerability and toxicity of oxaliplatin (Ox) a p...

  7. Egy fénykép ürügyén : Minni Nurme / Károly Árpás

    Index Scriptorium Estoniae

    Árpás, Károly

    2003-01-01

    Luulenäited tekstis: "Éjszaka árnyék vagyok..."; "A felhőkönnyek csÍraszálai..."; Őszi esten; "Fekete szivárványt..."; Folyosók; Szeptember; "eső esik hervasztja..."; Életöröm; "gyerekek alusznak..." (tõlkinud Károly Árpás)

  8. Using measured 30-150 kVp polychromatic tungsten x-ray spectra to determine ion chamber calibration factors, Nx (Gy C(-1)).

    Science.gov (United States)

    Mercier, J R; Kopp, D T; McDavid, W D; Dove, S B; Lancaster, J L; Tucker, D M

    2000-10-01

    Two methods for determining ion chamber calibration factors (Nx) are presented for polychromatic tungsten x-ray beams whose spectra differ from beams with known Nx. Both methods take advantage of known x-ray fluence and kerma spectral distributions. In the first method, the x-ray tube potential is unchanged and spectra of differing filtration are measured. A primary standard ion chamber with known Nx for one beam is used to calculate the x-ray fluence spectrum of a second beam. Accurate air energy absorption coefficients are applied to the x-ray fluence spectra of the second beam to calculate actual air kerma and Nx. In the second method, two beams of differing tube potential and filtration with known Nx are used to bracket a beam of unknown Nx. A heuristically derived Nx interpolation scheme based on spectral characteristics of all three beams is described. Both methods are validated. Both methods improve accuracy over the current half value layer Nx estimating technique.

  9. Clear Synthesis of Acetylsalicylic Acid catalyzed by GY Zeoite%脱铝改性Y分子筛催化清洁合成乙酰水杨酸

    Institute of Scientific and Technical Information of China (English)

    张康华; 徐庆荣; 曹小华; 陈义凡; 陶春元

    2009-01-01

    以水杨酸和乙酸酐为原料,脱铝改性分子筛为催化剂合成了乙酰水杨酸.考察催化剂用量、水杨酸和乙酸酐物料配比、反应时间、反应温度等因素对该反应的影响.结果表明:当n(水杨酸):n(乙酸酐)为1.0:1.2,催化剂用量为水杨酸质量的7.5%,80 ℃,反应10 min,产物收率达94.2%.

  10. COMPARISON OF MODELS WITH NEURAL NETWORK AND OLS-REGRESSION IN CONSTRUCTING THE RISK MANAGEMENT STRATE GY AGAINST THE INCOME ACCORDING TO INDEX

    Directory of Open Access Journals (Sweden)

    Vladimir N. Shchennikov

    2017-03-01

    Full Text Available Introduction: The models with neural network and OLS-regressions are used in the stock market and include variables that describe the state of the stock market. One of the possible ways to determine these dependencies is clusterization trough analizing principal components. The main aim of the research is revealing the essence of two promising heuristic approaches to assessment of the dynamics of functional relationships between the incomes in the stock market and variables that describe the state of the market. Materials and Methods: The source data are models with a continuous network and OLS-regression in the area of management strategies. Mathematical statistics revenue management strategies. Results: It is well known that specifics of functional relationship establishment between the income in the stock market lies in their clusterization through a linear (nonlinear analysis of principal components of the market condition. We analyzed two promising heuristic approaches to the assessment of the dynamics of functional relationships between the income in the stock market and variables describing the state of the market. Discussion and Conclusions: The analysis of the dynamics of functional links between the revenues on the stock market was made.

  11. Bakteriofágy - současné poznatky a možnosti jejich terapeutického využití

    OpenAIRE

    Glendová, Kristýna

    2016-01-01

    Bacteriophages, as viruses of bacteria, are the most abundand entity, populate every biotope where also bacteria live. One of the alternatives to combat infections caused by resistant strains of bacteria currently appear bacteriophage therapy, consists in the application of lytic bacteriophage, or only bacteriophage enzymes to inhibit bacterial growth. Thesis mentions the history of phage therapy, a crucial part of the thesis deals with a summary of current trends in bacteriophage therapy, be...

  12. 阿尔都塞意识形态概念的双重性解析%Analysis on the Duality of Althusser's Definition of Ideolo-gy

    Institute of Scientific and Technical Information of China (English)

    纪晓丽; 滕越

    2016-01-01

    意识形态概念从18世纪首次使用以来,经历了19世纪马克思的科学升华.到了19世纪末20世纪初,面对着马克思主义的危机,阿尔都塞又重新站出来"保卫马克思",通过批判意识形态无历史、对想象关系的表述以及理论实践的虚假性,建构其客观性、物质性、科学性的意识形态概念.%Since its first use in the 18th century, the definition of ideology has experienced a scientific sublimation by Marx in the 19th century. Faced with the crisis of Marxism in late 19th century and early 20th century, Althusser stood out to"defend Marx", and constructed an objective, material and scientific definition of ide-ology through criticizing the non-historical and imaginary repre-sentation of ideology as well as the falsity of theory and practice.

  13. Egy fénykép ürügyén : Minni Nurme / Károly Árpás

    Index Scriptorium Estoniae

    Árpás, Károly

    2003-01-01

    Luulenäited tekstis: "Éjszaka árnyék vagyok..."; "A felhőkönnyek csÍraszálai..."; Őszi esten; "Fekete szivárványt..."; Folyosók; Szeptember; "eső esik hervasztja..."; Életöröm; "gyerekek alusznak..." (tõlkinud Károly Árpás)

  14. Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response.

    Directory of Open Access Journals (Sweden)

    Thomas H P M Habets

    Full Text Available Accumulating evidence indicates that fractionated radiotherapy (RT can result in distant non-irradiated (abscopal tumour regression. Although preclinical studies indicate the importance of T cells in this infrequent phenomenon, these studies do not preclude that other immune mechanisms exhibit an addition role in the abscopal effect. We therefore addressed the question whether in addition to T cell mediated responses also humoral anti-tumour responses are modulated after fractionated RT and whether systemic dendritic cell (DC stimulation can enhance tumour-specific antibody production. We selected the 67NR mammary carcinoma model since this tumour showed spontaneous antibody production in all tumour-bearing mice. Fractionated RT to the primary tumour was associated with a survival benefit and a delayed growth of a non-irradiated (contralateral secondary tumour. Notably, fractionated RT did not affect anti-tumour antibody titers and the composition of the immunoglobulin (Ig isotypes. Likewise, we demonstrated that treatment of tumour-bearing Balb/C mice with DC stimulating growth factor Flt3-L did neither modulate the magnitude nor the composition of the humoral immune response. Finally, we evaluated the immune infiltrate and Ig isotype content of the tumour tissue using flow cytometry and found no differences between treatment groups that were indicative for local antibody production. In conclusion, we demonstrate that the 67NR mammary carcinoma in Balb/C mice is associated with a pre-existing antibody response. And, we show that in tumour-bearing Balb/C mice with abscopal tumour regression such pre-existing antibody responses are not altered upon fractionated RT and/or DC stimulation with Flt3-L. Our research indicates that evaluating the humoral immune response in the setting of abscopal tumour regression is not invariably associated with therapeutic effects.

  15. A global economic integration zone in Central Europe? Vienna-Bratislava-Györ as a laboratory for EU territorial cohesion policy

    NARCIS (Netherlands)

    Tatzberger, G.

    2006-01-01

    Central Europe is facing dramatic changes and huge challenges since the 40 years closed borders opened up. As part of central Europe the Vienna-Bratislava-Gyor area that straddles Austria, Hungary and Slovakia, faces new opportunities for co-operation and integration. The book gives a fascinating vi

  16. Test techniques for mol ecul ar biol 0gy 0f entomopathogenic fungi%虫生真菌的分子生物学检测技术

    Institute of Scientific and Technical Information of China (English)

    林华峰; 胡萃

    2001-01-01

    线粒体DNA探针、核糖体RNA编码DNA序列分析、随机扩增多态性DNA-聚合酶链式反应、基因组DNA探针和电泳核型分析,五类分子生物学技术在虫生真菌研究中已有应用.本文对此作了介绍,着重阐述了RAPD-PCR技术的特点及其使用此技术的研究成果.

  17. Muusikamaailm : Gergievi festival Rotterdamis. Los Angelese Ooper alustas. Luzerni festival tänaseni. Yaltah Menuhin lahkunud. Kyoto auhind György Ligetile / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Rotterdami Filharmoonikute peadirigendi V. Gergijevi korraldatud muusikafestivalist. Los Angelese Ooperi hooaja algusest. Luzerni festivalist šveitsis. Lühidalt Yaltah Menuhinist. G. Ligeti pälvis Kyoto elutöö-auhinna

  18. Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics

    OpenAIRE

    Levente Szalárdy; Dénes Zádori; Péter Klivényi; József Toldi; László Vécsei

    2015-01-01

    Impaired function of certain mitochondrial respiratory complexes has long been linked to the pathogenesis of chronic neurodegenerative disorders such as Parkinson’s and Huntington’s diseases. Furthermore, genetic alterations of mitochondrial genome or nuclear genes encoding proteins playing essential roles in maintaining proper mitochondrial function can lead to the development of severe systemic diseases associated with neurodegeneration and vacuolar myelinopathy. At present, all of these di...

  19. Optimum on acid-extraction technoloGy of pectin in Stauntonia latifolia pericarp by response surface methodoloGy%响应面法优化八月瓜果皮中果胶的酸提取工艺

    Institute of Scientific and Technical Information of China (English)

    李雪峰; 符智荣; 欧阳玉祝; 黄亚娟

    2014-01-01

    用盐酸提取八月瓜果皮的果胶,考察了pH 值、提取时间和提取温度对果胶得率的影响。结果表明,pH值、温度对果胶得率有显著影响,八月瓜果皮果胶提取的最佳工艺条件为:pH=1,提取时间156 min,提取温度91℃,果胶得率为7.11%。%With StauNtONia latifOlia as experimental raw material,extraction technology of pectin in StauN-tONia latifOlia pericarp was studied. Influence of pH,extraction time and extraction temperature on extrac-tion ratio of pectin were investigated by response surface methodology. Experimental results show that the best process condition of extraction ratio of pectin is 7. 11% at pH=1 and 91 ℃,extraction 156 min.

  20. Collide@CERN: sharing inspiration

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    Late last year, Julius von Bismarck was appointed to be CERN's first "artist in residence" after winning the Collide@CERN Digital Arts award. He’ll be spending two months at CERN starting this March but, to get a flavour of what’s in store, he visited the Organization last week for a crash course in its inspiring activities.   Julius von Bismarck, taking a closer look... When we arrive to interview German artist Julius von Bismarck, he’s being given a presentation about antiprotons’ ability to kill cancer cells. The whiteboard in the room contains graphs and equations that might easily send a non-scientist running, yet as Julius puts it, “if I weren’t interested, I’d be asleep”. Given his numerous questions, he must have been fascinated. “This ‘introduction’ week has been exhilarating,” says Julius. “I’ve been able to interact ...

  1. Noncommutative QFT and renormalization

    Science.gov (United States)

    Grosse, H.; Wulkenhaar, R.

    2006-03-01

    It was a great pleasure for me (Harald Grosse) to be invited to talk at the meeting celebrating the 70th birthday of Prof. Julius Wess. I remember various interactions with Julius during the last years: At the time of my studies at Vienna with Walter Thirring, Julius left already Vienna, I learned from his work on effective chiral Lagrangians. Next we met at various conferences and places like CERN (were I worked with Andre Martin, an old friend of Julius), and we all learned from Julius' and Bruno's creation of supersymmetry, next we realized our common interests in noncommutative quantum field theory and did have an intensive exchange. Julius influenced our perturbative approach to gauge field theories were we used the Seiberg-Witten map after his advice. And finally I lively remember the sad days when during my invitation to Vienna Julius did have the serious heart attack. So we are very happy, that you recovered so well, and we wish you all the best for the forthcoming years. Many happy recurrences.

  2. Noncommutative QFT and renormalization

    Energy Technology Data Exchange (ETDEWEB)

    Grosse, H. [Institut fuer Theoretische Physik, Universitaet Wien, Boltzmanngasse 5, 1090 Wien (Austria); Wulkenhaar, R. [Mathematisches Institut der Westfaelischen Wilhelms-Universitaet, Einsteinstrasse 62, 48149 Muenster (Germany)

    2006-03-01

    It was a great pleasure for me (Harald Grosse) to be invited to talk at the meeting celebrating the 70th birthday of Prof. Julius Wess. I remember various interactions with Julius during the last years: At the time of my studies at Vienna with Walter Thirring, Julius left already Vienna, I learned from his work on effective chiral Lagrangians. Next we met at various conferences and places like CERN (were I worked with Andre Martin, an old friend of Julius), and we all learned from Julius' and Bruno's creation of supersymmetry, next we realized our common interests in noncommutative quantum field theory and did have an intensive exchange. Julius influenced our perturbative approach to gauge field theories were we used the Seiberg-Witten map after his advice. And finally I lively remember the sad days when during my invitation to Vienna Julius did have the serious heart attack. So we are very happy, that you recovered so well, and we wish you all the best for the forthcoming years. Many happy recurrences. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

  3. El “Liber Pontificalis de Agnello de Rávena”(s. IX), la génesis del valor histórico y de la didáctica de los “monumentos” en la “Literatura artística de Julius von Schlosser.

    OpenAIRE

    Arjones Fernández, A.

    2005-01-01

    La Nueva Historia del Arte, la Escuela de Viena, supone una renovación para la didáctica de la Historia del Arte en la medida en que reconoce "otras" utilidades al patrimonio cultural, entonces denominado "monumento". El Liber Pontificalis de Agnello fue considerado una fuente documental, la Nueva Historia del Arte concedió a este documento la condición de fuente documental para la Historia del Arte. Este trabajo se expuso en el Simposio de los códices medievales a los libros de artista: c...

  4. El “Liber Pontificalis de Agnello de Rávena”(s. IX), la génesis del valor histórico y de la didáctica de los “monumentos” en la “Literatura artística de Julius von Schlosser.

    OpenAIRE

    Arjones Fernández, A.

    2005-01-01

    La Nueva Historia del Arte, la Escuela de Viena, supone una renovación para la didáctica de la Historia del Arte en la medida en que reconoce "otras" utilidades al patrimonio cultural, entonces denominado "monumento". El Liber Pontificalis de Agnello fue considerado una fuente documental, la Nueva Historia del Arte concedió a este documento la condición de fuente documental para la Historia del Arte. Este trabajo se expuso en el Simposio de los códices medievales a los libros de artista: c...

  5. ‘A dialogue about the art of portraiture’ Originally published as ‘Gespräch von der Bildniskunst’, Österreichische Rundschau, Volume 6, 1906, 502—516, and republished: Julius Schlosser, Präludien Vorträge und Aufsätze, Berlin: Bard 1927, 227—247. Translated with an introduction by Karl Johns

    Directory of Open Access Journals (Sweden)

    Julius Schlosser

    2011-12-01

    Full Text Available In an unusually popular and readable dialogue form, Schlosser alludes to the classical education he takes for granted in any reader approaching his favourite ‘thorny’ questions from aesthetics and history. These involve the problems of naturalism, impressionism, portrait likeness, psychology of perception and numerous others being bandied around academic circles at the turn of the century. It is of further interest in directly referring critically to his recently deceased friend (Alois Riegl, and being written just at a moment in his career when Schlosser had been casting around the ideas of Ernst Brücke, Konrad Lange, even Henri Bergson, but had discovered the recent contribution of Benedetto Croce, which would colour his approach with an increasing intensity for the remainder of his life. He became what might be seen as the archetypical art historical theorist, but continues to distinguish himself from his successors by his greater consistency.

  6. Pierre Swiggers, Les Conceptions linguistiques des Encyclopédistes, Etude sur Ia constitution d'une théorie de Ia grammaire au siècle des Lumières, Sammlung Groos 21, Julius Groos Verlag-Heidelberg- Leuven University Press, Heidelberg 1984, 165 pp.

    Directory of Open Access Journals (Sweden)

    Pavao Tekavčić

    1986-12-01

    Full Text Available Le petit livre dont nous présentons ici lecompte rendu est I'oeuvre du jeune savant Pierre Swiggers, chercheur qualifié au Fonds national beige de la recherche scientifique, linguiste et philologue qui nous a donné dejà une serie d'études, sur le siècle des Lumières (L'Encyclopédie et la linguistique au XVI/le siècle, «Linguisti­ cae Investigationes» 311979; La grammaire dans /'Encyclopédie: Etat actuel des étu­ des, «Beiträge zur romanischen Philologie» 20/1981; La théorie syntaxique dans  /'Encyclopédie, «Lingua e stile» 18/1983 etc., sur l'historiographie linguistique (tout récemment: L'article en français: l'histoire d'un problème grammatical, «Re­ vue de Linguistique Romane» 49/1985, sur la linguistique du XVIIe et du XVIIIe siècle en général, etc. L'Auteur est done bien un spécialiste qualifié pour offrir au public linguistique une synthèse de ses recherches sur les théories grammaticales dans l'Encyclopédie.

  7. Addendum: Qian, C.; Fang, Q.; Wang, L.; Ye, G.Y. Molecular Cloning and Functional Studies of Two Kazal-Type Serine Protease Inhibitors Specifically Expressed by Nasonia vitripennis Venom Apparatus. Toxins 2015, 7, 2888–2905

    Directory of Open Access Journals (Sweden)

    Cen Qian

    2015-09-01

    Full Text Available This research was supported by grants from the National Program on Key Basic Research Projects (973 Program, 2013CB127600, the National Natural Science Foundation of China (Grant Nos. 31272098, 31472038, 31402018, the Research Fund for the Doctoral Program of Higher Education of China (Grant Number 2012010113004, the National Science Fund for Innovative Research Groups of Biological Control (Grant No. 31321063, the Zhejiang Provincial Natural Science Foundation of China (Grant Number Y14C140006 and the Fundamental Research Funds for the Central Universities (Grant Number 2014FZA6014. [...

  8. Nuclear Weapon Effect Research at PSR (Pacific-Sierra Research Corporation) - 1983. Symptomatology of Acute Radiation Effects in Humans after Exposure to Doses of 75 to 4500 Rads (cGy) Free-in-Air

    Science.gov (United States)

    1984-08-31

    50, Her Majesty’s Stationery Office, London, 1957, 20.- , "Mortality from Cancer and Other Causes after Radiotherapy for Ankylosing Spondylitis , 8r...low tolerance to exercise with consequent risk of hyperthermia. PROBLEMS IN ASSESSING SYMPTOMS Advances in therapeutic methods have introduced

  9. The Features of Old Sports and the Development Strate-gy of Organization and Management%老年体育活动的特点及组织管理发展策略研究

    Institute of Scientific and Technical Information of China (English)

    刘桂彩

    2014-01-01

    Participation in sports starting from the elderly, the elderly based on different forms of participation in sports activities, to participate in the project as well as participation in sports motivation,the analysis of the eld-erly reasons for the lack of sports management, and from the organization and management, business model, laws and regulations made constructive comments, etc. , in or-der to promote the development of the country�s aging sports organization management.%从老年人体育参与现状入手,依据老年人不同的参与体育活动的形式、参与项目以及参与体育活动的动机,分析我国老年体育管理人员缺失的原因,并从组织管理、经营模式、法律法规等方面提出建设性意见,以期促进我国老年体育组织管理的发展。

  10. APPLICATION OF ACOUSTIC TECHNOLO GY TO SE ISMO-STRATIGRAPHY SURVEYING IN OFFSHORE%声学探测技术在近岸水域地震地层探测中的应用

    Institute of Scientific and Technical Information of China (English)

    王揆洋; 郑彦鹏; 王述功

    1999-01-01

    对山东省海阳市冷家庄东南近岸海域浅、中深层地层声学探测剖面进行了分析对比, 对研究区内的地震地层层序和基岩构造特征进行了判识,探明研究区存在着3个地震反射波层组,分别代表了3套不同形成时代、不同沉积结构的地层,综合海底浅层柱状取样结果及陆上地层露头情况,推测这3个地震反射波层组分别与第四纪浅海相泥砂质沉积、白垩纪莱阳群中上部的中、薄层粉砂岩和莱阳群的厚层石英砂岩相对应.并且,发育于基岩内的断层构造在第二、三反射波层组内具有明显显示,但均未延伸至第一反射波层组.

  11. Long-term brain structural magnetic resonance imaging and cognitive functioning in children treated for acute lymphoblastic leukemia with high-dose methotrexate chemotherapy alone or combined with CNS radiotherapy at reduced total dose to 12 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Zajac-Spychala, Olga; Pilarczyk, Jakub; Derwich, Katarzyna; Wachowiak, Jacek [Poznan University of Medical Sciences, Department of Pediatric Oncology, Hematology and Transplantology, Poznan (Poland); Pawlak, Mikolaj A. [Poznan University of Medical Sciences, Department of Neurology and Cerebrovascular Disorders, Poznan (Poland); Karmelita-Katulska, Katarzyna [Poznan University of Medical Sciences, Department of Neuroradiology, Poznan (Poland)

    2017-02-15

    The aim of this study was to assess the long-term side effects of central nervous system prophylaxis (high-dose chemotherapy alone vs chemotherapy and CNS radiotherapy) according to the ALL IC-BFM 2002. Thirty-tree children aged 6.7-19.9 years have been studied. The control group consisted of 12 children newly diagnosed with acute lymphoblastic leukemia. We assessed subcortical gray matter volume using automatic MRI segmentation and cognitive performance to identify differences between two therapeutic schemes and patients prior to treatment. Patients treated with chemotherapy and CNS radiotherapy had smaller hippocampi than two other subgroups and lower IQ score than patients treated with chemotherapy alone. Both treated groups, whether with chemotherapy only or in combination with CNS radiotherapy, had significantly lower volumes of caudate nucleus and performed significantly worse on measures of verbal fluency in comparison with patients prior to treatment. There were no differences in the mean volumes of total white matter, total gray matter, thalamus, putamen, and amygdala between the studied groups. In all children treated according to the ALL IC-BFM 2002 with high-dose chemotherapy, both decreased volume of selected subcortical structures and cognitive impairment was observed, especially in children who received chemotherapy in combination with reduced dose CNS radiotherapy. In all children treated according to the ALL IC-BFM 2002 with high-dose chemotherapy, both decreased volume of selected subcortical structures and cognitive impairment were observed, especially in children who received chemotherapy in combination with CNS radiotherapy. (orig.)

  12. The Application and Practice of the Multimedia Technolo-gy in College Mathematics Teaching%多媒体技术在高校数学公共教学中的应用与实践

    Institute of Scientific and Technical Information of China (English)

    姚荃; 莫宏敏; 黄羿

    2015-01-01

    With the development of modern education technology, multimedia is being used more widely in education. The particu-larity of mathematics education restricts the application of multi-media technology in mathematics education. How to make use of the advantages of multimedia technology and overcome the de-fects of the traditional teaching mode, is a problem mathematics educators must solve.%随着现代教育技术的发展,多媒体在教育领域中的应用越来越广泛。数学教学的特殊性,使得多媒体在其中的运用受到了很大的限制。如何利用多媒体教学的优势,克服传统教学的局限性,是数学教育工作者必须解决的问题。

  13. La Fuerza Aérea Colombiana a través del Instituto Militar Aeronáutico recibe el premio LoGyCA 2009 a la innovación en redes de valor

    Directory of Open Access Journals (Sweden)

    Javier Parra González

    2009-01-01

    Full Text Available La Fuerza Aérea Colombiana recibio el Premio LOGyCA a Ia lnnovación en Redes de Valor en el año 2009, por parte de Ia organlzaclon "LOGyCA, GS1 Colombia", hecho de suma lmportancla al reconocer el esfuerzo institucional por mejorar las prácticas logísticas, otorgado por una organizaci6n que lldera, promuave y galardona Ia prácticas  logísticas que contribuyen al desarrollo de las empresas en Colombia, este reconoclmlento se otorgo al trabajo de  grado  desarrollado por un personal de alumnos del Instituto Militar  Aeronàutico para optar el instituto de especialistas en logística aeronáutica.

  14. “3S”技术在现代地理教学中的创新性应用研究%Research on the Innovative Application of "3S" Technolo-gy in Modern Geography Teaching

    Institute of Scientific and Technical Information of China (English)

    张亦汉; 乔纪纲; 李建程; 吴锐佳

    2014-01-01

    “3S”技术带来了巨大的社会效益和经济效益,已受到世界各国的高度重视和社会公众的广泛关注。现代地理学是地理学和现代科技结合的最新阶段,同样也需要先进的“3S”技术的支持。文中以网络GIS与远程教育、基于LBS的位置共享与“外地理实习、虚拟现实与现实教学等例子说明了“3S”在现代地理教学的创新性工作。引入该技术也将会提高课堂教学效率降低教学成本,适应现代地理学的发展,增强学生的理解能力。%"3S" technology has drawn much attention of coun-tries and the public because of tremendous social and econom-ic benefits. Modern geography is the latest stage of geography combined with modern technology, which is deepened on ad-vanced "3S" technology. This paper illustrated innovative work by introducing"3S"into modern geography teaching. The work includes web GIS in remote education, LBS in geography prac-tice, virtual reality in geography teaching. The "3S" technology will help to improve teaching efficiency, reduce the teaching cost, adapt to modern geography, and enhance students' com-prehension.

  15. 蓝萼甲素的药理活性及其机制和毒理作用的研究进展%Advances on the research of the pharmacological activity mechanism and toxicolo-gy of Glaucocalyxin A

    Institute of Scientific and Technical Information of China (English)

    迟晴晴; 王强; 钟延强

    2016-01-01

    蓝萼甲素(glaucocalyxin A,GLA)是一种具有对映15-氧-16贝壳杉烯(ent-15-oxo-16-kaurene)骨架结构的二萜类化合物.其具有心血管保护、内皮保护、抗凝血、抗乙肝病毒、抗肿瘤、抑菌、抗炎、耐缺氧、免疫抑制及调节钙离子浓度等多种药理作用,并且有很高的体内安全性.民间常用蓝萼香茶菜治疗肝炎、胃炎、乳腺炎、腹痛、关节痛等疾病,临床上蓝萼香茶菜主要用于治疗冠心病、心绞痛、脑供血不足等缺血、缺氧性心脑血管疾病.本研究将对蓝萼甲素的药理作用及其机制和毒理学作用做一总结.%Glaucocalyxin A (GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene.It has various pharmacological activities,such as cardiovascular and endothelium cellular protection,anti-blood coagu-lation,anti-Hepatitis B Virus (HBV),anti-tumor,anti-bacteria,anti-inflammation,hypoxic tolerance,immunomodulation and Ca2+ concentration regulation effect,where as its in vivo safety is quite good.As a folk medicine,it is conventionally used to treat hepatitis,gastritis,mastitis,stomachache and arthralgia.It is also used for ischemic and/or hypoxic cardio-cerebrovas-cular diseases such as coronary heart diseases,stenocardia and chronic cerebral circulation insufficiency in clinic.This review gives a summary of the pharmacological effects,biological mechanism,and toxicity of Glaucocalyxin A.

  16. 应用信息粒方法构建测井岩性解释模型%USING INFORMATION GRANULATION TO CONSTRUCT THE WELL-LOGGING LITHOLO-GY INTERPRETATION MODEL

    Institute of Scientific and Technical Information of China (English)

    余翔宇; 徐义贤; 骆淼

    2012-01-01

    基于模糊聚类、神经网络等常用测井岩性识别方法,提出应用信息粒(Information Granulation)技术建立测井数据到岩性知识的映射模型.并以中国大陆科学钻探(CCSD)的测井数据为例,详细介绍了这种岩性解释方法的应用过程及其所取得的良好应用效果.%By analyzing some data processing methods which are common used in well-logging as fuzzy clustering, Artificial neural network etc. the paper consequently presents the method based on information granulation (IG) to construct the mapping model from well-logging data to lithol-ogy knowledge. Take the well - logging data from Chinese continental scientific drilling (CCSD) as an instance, the author described how to establish such interpretation model and an excellent results it had achieved.

  17. Oncological outcomes from trimodality therapy receiving definitive doses of neoadjuvant chemoradiation (≥60 Gy and factors influencing consideration for surgery in stage III non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Melissa A.L. Vyfhuis, MD PhD

    2017-07-01

    Conclusions: Trimodality treatment significantly improves survival and FFR in patients with LA-NSCLC when definitive doses of radiation with neoadjuvant chemotherapy are employed. We identified important demographic features that predict the use of surgical intervention in patients with stage III NSCLC.

  18. Writing at the 50th anniversary of publication of Ex perimental Technolo gy and M anagement%写在《实验技术与管理》创刊50周年

    Institute of Scientific and Technical Information of China (English)

    潘际銮

    2013-01-01

    According to the epistemology of dialectical materialism , the practice is the only way to understand the whole world and the impersonal rules .Taking three great inventions in modern scientific and technological history as examples , this article expounds that all great inventions in history stem from scientific propositions of practice .Wish the Experimental Technology and Management to continualy go fo rw ard .%根据辩证唯物主义的认识论,实践是了解世界和客观规律的唯一办法。以近代科技史上3个重大创造发明事例,阐述了历史上的重大发明创造都来源于实践的科学命题。祝愿《实验技术与管理》继续前进,更上一层楼。

  19. Short androgenic suppression and high dose radiotherapy (80 Gy) for prostate cancer with intermediate risk: interim analysis of randomized trial 14 by the Group of uro-genital tumour investigations (Getug); Suppression androgenique courte et radiotherapie de haute dose (80 Gy) pour cancer prostatique de risque intermediaire: analyse interimaire de l'essai randomise 14 du Groupe d'etudes des tumeurs urogenitales (Getug)

    Energy Technology Data Exchange (ETDEWEB)

    Dubray, B. [CRLCC Henri-Becquerel, Rouen (France); Beckendorf, V.; Harter, V. [CRLCCAIexis-Vautrin, Vandceuvre- les-Nancy (France); Guerif, S. [CHU La Miletrie, Poitiers (France); Le Prise, E. [CRLCCEugene-Marquis, Rennes (France); Reynaud-Bougnoux, A. [Corad Henry-S.-Kaplan, Tours (France); Hannoun Levi, J.M. [CRLCCAntoine-Lacassagne, Nice (France); Nguyeng, T.D. [InstitutJean-Godinot, Reims (France); Hennequin, C. [CHU Saint-Louis, Paris (France); Cretin, J. [Clinique de Valdegour, Nimes (France)

    2011-10-15

    The authors report an interim analysis of a randomized trial for the assessment of the contribution of a short androgenic suppression to a high-dose irradiation on patients suffering from an intermediate risk localized prostate cancer. The study concerned a bit less than 400 patients treated between 2003 and 2010. About half of them had hormonotherapy, and the other half not. Results are discussed in terms of biochemical or clinical control probability, of cumulative grade-3 and grade-4 toxicity rates. The benefit of androgenic suppression does not reach a statistic significant threshold. Short communication

  20. Caesar : iiri hiiglane / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2006-01-01

    Iiri päritolu näitleja Ciaran Hinds, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesarit. Sama ka : Teleleht nr. 49, lk. 14 : ill

  1. Tavaline roomlane / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2007-01-01

    Iiri päritolu näitleja Ray Richardson, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesari sõdurit Titus Pullot. Sama : Teleleht nr. 1, lk. 14 : ill

  2. South Africa: ANC Youth League President found guilty of hate speech.

    Science.gov (United States)

    Sinclair, Kelly

    2010-06-01

    On 15 March 2010, the Johannesburg Equality Court found African National Congress (ANC) Youth League President Julius Malema guilty of hate speech and harassment for his comments regarding rape survivors.

  3. A Symposium on Pre-1900 Classics Worth Using in School.

    Science.gov (United States)

    English Journal, 1983

    1983-01-01

    Various contributors recommend "The Odyssey,""Julius Caesar,""A Dog's Tale,""Ivanhoe,""Star Wars,""The Red Badge of Courage,""Demian,""Antigone,""Children of Crisis," and "Frankenstein" for use in literature classes and justify their recommendations. (JL)

  4. Stability and the Union in Tanzania

    African Journals Online (AJOL)

    dence in December 1961 under the leadership of Mwalimu Julius Nyerere. The transition ..... declared the CCM presidential candidate, Salmin Armour, as duly elected ..... The issue of the electoral politics and conflict management in Tanzania,.

  5. "Casablancal" on aegade parim stsenaarium

    Index Scriptorium Estoniae

    2006-01-01

    Ameerika stsenaristide gild (Writers' Guild of America) valis kõikide aegade parimaks filmistsenaariumiks "Casablanca" : stsenaristid Julius ja Philip Epstein, Howard Koch : režissöör Michael Curtiz : Ameerika Ühendriigid 1942

  6. 78 FR 67386 - Announcement of Funding Awards; Indian Community Development Block Grant Program Fiscal Year 2013

    Science.gov (United States)

    2013-11-12

    .... Muscogee (Creek) Nation, George Tiger, 800,000 PF Food distributiong Grocery Principal Chief, P.O. Box 580...-722-4656. creation of 2 permanent jobs. Village of Venetie, Julius Roberts, First 600,000 HC...

  7. variant termination of the common carotid artery: cases of ...

    African Journals Online (AJOL)

    2014-12-10

    Dec 10, 2014 ... Julius Ogeng'o, Department of Human Anatomy, University of Nairobi PO Box 30197 00100 Nairobi. .... Vagus nerve is also shown. .... Mr. Jacob Gimongo and Charles Nzioka for ... Neuroimaging Clin N Am 6: 789 – 799. 12.

  8. Case report

    African Journals Online (AJOL)

    abp

    Cerebral venous sinus thrombosis in HIV-infected patients: report of 2 cases. Julius Chacha ... affected adults are women, and direct causes or predisposing risk factors can be .... Some studies have reported a high prevalence of antibodies.

  9. Tavaline roomlane / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2007-01-01

    Iiri päritolu näitleja Ray Richardson, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesari sõdurit Titus Pullot. Sama : Teleleht nr. 1, lk. 14 : ill

  10. Caesar : iiri hiiglane / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2006-01-01

    Iiri päritolu näitleja Ciaran Hinds, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesarit. Sama ka : Teleleht nr. 49, lk. 14 : ill

  11. "Casablancal" on aegade parim stsenaarium

    Index Scriptorium Estoniae

    2006-01-01

    Ameerika stsenaristide gild (Writers' Guild of America) valis kõikide aegade parimaks filmistsenaariumiks "Casablanca" : stsenaristid Julius ja Philip Epstein, Howard Koch : režissöör Michael Curtiz : Ameerika Ühendriigid 1942

  12. Kõpu mõisas taastatakse Cicero maja seinamaalingute koopiaid / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2006-01-01

    Viljandimaa Kõpu mõisakooli söögisaali seinamaalingute restaureerimisest. Perekond von Strykile kuulunud mõisa peahoone valmis 1847. a. arhitekt Emil Julius Straussi projekti järgi. Restaureerimistöid teostab OÜ Vana Tallinn

  13. Kirjad üle mere / Aksel Mark

    Index Scriptorium Estoniae

    Mark, Aksel, 1913-2014

    2001-01-01

    rets. rmt.: Kirjad üle mere : Mart Lepiku kirjavahetus Julius Mägiste, Karl Ristikivi ja Bernard Kangroga / Eesti Kirjandusmuuseum; koostanud ja kommenteerinud Sirje Olesk. Tartu : Eesti Kirjandusmuuseum, 2000. 160 lk. (Litteraria; 19)

  14. Baltluse sarm / Peeter Künstler

    Index Scriptorium Estoniae

    Künstler, Peeter, 1958-2009

    1999-01-01

    Arvustus: Bergengruen, Werner. Surm Tallinnas / saksa keelest tõlkinud Rein Sepp, Mati Sirkel. Tallinn : Varrak, 1999. Schultz-Bertram, Georg Julius. Tartu tudengid viiskümmend aastat tagasi / saksa keelest Viktor Sepp. Tallinn : Perioodika, 1999. (Loomingu Raamatukogu; 17)

  15. No Time for Love: Plutarch’s Chaste Caesar

    Directory of Open Access Journals (Sweden)

    Jeffrey Beneker

    2006-03-01

    Full Text Available Plutarch’s biography of Julius Caesar, compared with other accounts, deliberately plays down sexuality as a motive in Caesar's life, in order to stress his single-minded political ambition.

  16. Kunstnik ja tema kodu : Carl Timoleon von Neff Piira ja Muuga mõisas / Ants Hein

    Index Scriptorium Estoniae

    Hein, Ants, 1952-

    2004-01-01

    Ateljeedest Euroopas alates 15. sajandist ja Eestis alates 19. sajandist. Pikemalt Julius Kleveri ja Otto Moelleri ateljeest. Maalikunstnik Carl Timoleon von Neffi elust ja loomingust, kunsti kollektsioneerimisest. Piira ja Muuga mõisahoonest, plaanid, sise- ja välisvaated

  17. A Symposium on Pre-1900 Classics Worth Using in School.

    Science.gov (United States)

    English Journal, 1983

    1983-01-01

    Various contributors recommend "The Odyssey,""Julius Caesar,""A Dog's Tale,""Ivanhoe,""Star Wars,""The Red Badge of Courage,""Demian,""Antigone,""Children of Crisis," and "Frankenstein" for use in literature classes and justify their recommendations. (JL)

  18. Ja mul oli veel nii palju öelda! / Marju Kõivupuu

    Index Scriptorium Estoniae

    Kõivupuu, Marju, 1960-

    2006-01-01

    Ka järgmistest raamatutest: Schultz-Bertram, Georg Julius. Balti idealisti kirjad emale / tlk. Ilmar Vene. Tartu : Ilmamaa, 2003 ; Dr. Bertram. Tartu tudengid viiskümmend aastat tagasi / saksa keelest Viktor Sepp. Tallinn : Perioodika, 1999. (Loomingu Raamatukogu ; 17) ; Pärnik, Ylo M. Dr Georg Julius von Schultz-Bertram. Tartu : Ilmamaa, 2006 ; Dr. Bertram. Kolm Tartu balli / tlk. Viktor Sepp. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 26)

  19. Ja mul oli veel nii palju öelda! / Marju Kõivupuu

    Index Scriptorium Estoniae

    Kõivupuu, Marju, 1960-

    2006-01-01

    Ka järgmistest raamatutest: Schultz-Bertram, Georg Julius. Balti idealisti kirjad emale / tlk. Ilmar Vene. Tartu : Ilmamaa, 2003 ; Dr. Bertram. Tartu tudengid viiskümmend aastat tagasi / saksa keelest Viktor Sepp. Tallinn : Perioodika, 1999. (Loomingu Raamatukogu ; 17) ; Pärnik, Ylo M. Dr Georg Julius von Schultz-Bertram. Tartu : Ilmamaa, 2006 ; Dr. Bertram. Kolm Tartu balli / tlk. Viktor Sepp. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 26)

  20. Fanon's Children: The Black Panther Party and the Rise of the Crips and Bloods in Los Angeles

    OpenAIRE

    Barganier, George

    2011-01-01

    Black nationalists of the Black Power era often viewed Black criminality as an essential component to Black political consciousness. "There have been those black Americans who have resisted white America," activist Julius Lester argued. "These were the field niggers during slavery, Nat Turner, the Black abolitionists, Garvey, and in our own time, Malcolm, the hustler on the corner and the high-school dropout." Scholars have amply demonstrated the ideological logic of Julius Lester's thinki...

  1. Keeping the Dogs in the Fight: What Combatant Commanders Need to Know about MWDs

    Science.gov (United States)

    2013-05-20

    slip the dogs of war…” 1 - William Shakespeare INTRODUCTION The need to further examine additional capabilities of Military Working Dogs...1 William Shakespeare . “Julius Caesar,” The Literature Network. Last modified 2012, http://www.online...literature.com/ shakespeare /julius_caesar/9/. 2 Air Force Office of Scientific Research, Conference on Research to Expand the Usefulness of the Military

  2. Automatic temporal segment detection via bilateral long short-term memory recurrent neural networks

    Science.gov (United States)

    Sun, Bo; Cao, Siming; He, Jun; Yu, Lejun; Li, Liandong

    2017-03-01

    Constrained by the physiology, the temporal factors associated with human behavior, irrespective of facial movement or body gesture, are described by four phases: neutral, onset, apex, and offset. Although they may benefit related recognition tasks, it is not easy to accurately detect such temporal segments. An automatic temporal segment detection framework using bilateral long short-term memory recurrent neural networks (BLSTM-RNN) to learn high-level temporal-spatial features, which synthesizes the local and global temporal-spatial information more efficiently, is presented. The framework is evaluated in detail over the face and body database (FABO). The comparison shows that the proposed framework outperforms state-of-the-art methods for solving the problem of temporal segment detection.

  3. Schlosser and Montaigne in the Festschrift for Franz Wickhoff’: Julius Schlosser, ‘Glosses on a passage in Montaigne’, Originally published as: ‘Randglossen zu einer Stelle Montaignes’, Beiträge zur Kunstgeschichte, Franz Wickhoff gewidmet von einem Kreise von Freunden und Schülern, Vienna: Schroll, 1903, 172-182 and reprinted in Schlosser, Präludien Vorträge und Aufsätze, Berlin: Bard, 1927, 213-226.

    Directory of Open Access Journals (Sweden)

    Karl Johns

    2015-06-01

    Full Text Available Earlier theories about the origins of decoration supposed that forms such as the widespread zig-zag motif in ornamental art originated as a ‘naturalistic’ imitation of lightning in the sky or the movements of snakes along the surface of the earth. Evidence exists that actual naturalistic imitation as we know it only became conscious far later and that art originally and more fundamentally expressed feelings or impressions based on such figments as what had been called ‘memory images.’

  4. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS

    DEFF Research Database (Denmark)

    Chin, Chee Tang; Roe, Matthew T; Fox, Keith A A;

    2010-01-01

    Practice guidelines recommend dual antiplatelet therapy with aspirin and clopidogrel for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) regardless of in-hospital management strategy. Prasugrel-a thienopyridine adenosine diphosphate receptor antagonist that provides...

  5. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS

    DEFF Research Database (Denmark)

    Chin, Chee Tang; Roe, Matthew T; Fox, Keith A A;

    2010-01-01

    Practice guidelines recommend dual antiplatelet therapy with aspirin and clopidogrel for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) regardless of in-hospital management strategy. Prasugrel-a thienopyridine adenosine diphosphate receptor antagonist that provides...... higher and less variable levels of platelet inhibition than clopidogrel-has demonstrated benefit when used to treat ACS patients undergoing percutaneous coronary intervention. However, the optimal approach to antiplatelet therapy for high-risk, medically managed NSTE ACS patients remains uncertain...

  6. Comparison of tear film tests, ocular staining, impression cytool gy for three conditions:dry eye, anterior blepharitis, season al allergic conjunctivitis%干眼症和前睑缘炎及季节性过敏性结膜炎中三种检测方法结果的比较

    Institute of Scientific and Technical Information of China (English)

    Mutlu Acar; Volkan Yaylalı; Ahmet çevik Tufan; Cem Yıldırım

    2013-01-01

    AIM:To compare three clinically similar patient groups and a control group in terms of tear function tests, ocular surface staining and conjunctival impression cytology. METHODS: This was a single-centre, prospective, double-blind, randomised and controlled trial.The study includes 20 dry eye patients with Schirmer 1 scores less than 10mm and a tear film break-up time ( TBUT) less than 10s, 20 anterior blepharitis patients with drying and crusting of the eyelashes, 20 seasonal allergic conjunctivitis patients with papillary hypertrophy of the upper eyelid tarsal conjunctiva and 20 control group patients. The Schirmer scores, TBUT scores, ocular surface staini ng ( as graded by the Oxford scheme scale) , goblet cell density ( as observed using impression cytology and metaplasia scores for all patients evaluated by the Nelson grading scheme) were compa red. RESULTS: Significant differences were identified between these patient groups and the control group in terms of tear functions tests, ocular surface-staining scores, goblet cell density and metaplasia scores (P<0.001). CONCLUSION: Inflammatory response against these three diseases was demonstrated to cause damage in parallel to the severity of the local inflammation they generate on the ocular surface.We confirmed that this damage has very serious effects, especially on conjunctival goblet cell density and metaplasia. We believe that the degree of this loss in goblet cells is correlated with clinical findings.%目的:比较三组临床患者和对照组患者的泪液功能测试,眼表染色以及结膜印象细胞学检测的结果。方法:这是一个单中心,前瞻性,双盲,随机对照试验。研究包括泪液分泌分数小于10 mm和泪膜破裂时间( TBUT )小于10 s的20例干眼症患者,有干燥和结痂睫毛的20例前睑缘炎患者,上眼睑睑板结膜乳头肥大的20例季节性过敏性结膜炎患者和20例对照组患者。比较泪液分泌的分数,泪膜破裂时间,眼表染色(牛津分级方案),杯状细胞密度(尼尔森分级方案评估所有患者的印象细胞学和化生分数)。结果:三组患者和对照组患者在泪液功能测试结果,眼表染色评分,杯状细胞密度和化生分数上有显著差异(P<0.001)。结论:结果证明这三种疾病的炎症反应造成严重眼表损害,并在局部产生炎症。这种损伤产生非常严重的影响,尤其是对结膜杯状细胞密度和化生。杯状细胞损伤程度与临床研究结果有关联。

  7. QCC管理工具在提高妇科人流吸管清洗合格率中的运用%The QCC management tools to improve the qualified rate in the use of gy-necological abortion Straw cleaning

    Institute of Scientific and Technical Information of China (English)

    李敏

    2014-01-01

    Objective To improve gynecological abortion lumen cleaning quality, reduce or eliminate the incidence of nosocomial infection. Methods In nursing quality management process, in allusion to the problems of quality flow lumen equipment cleaning, using QCC management tool, the department all circle through brainstorming, benefit by mutual discussion, analysis of the existing problems, to explore the implementation of countermeasures, solve problems together. Results The of the implementation of activity after four months, the tangible and intangible results results improved significantly, the activity before and after comparison, people Straw cleaning qualified rate were 86.99% and 98.04%. Conclusion Application of circle management tool through the quality control department, all team members involved in quality management consciousness, team cohesion, enhance the overall quality of work responsibility, improvement, cleaning people Straw qualified rate is higher.%目的:提高妇科人流管腔器械清洗质量,降低或杜绝医院感染发生率。方法在科室质量管理过程中,针对人流管腔器械清洗质量存在问题,运用品管圈管理工具,科室全体圈员通过头脑风暴,集思广益,分析存在问题,探讨实施对策,共同解决问题。结果实施活动四个月后,有形成果和无形成果得到明显提升,经活动前后对比,人流吸管清洗合格率分别为86.99%和98.04%。结论通过品管圈管理工具的应用,科室全体圈员参与质量管理的意识、团队凝聚力、责任心增强,整体工作质量得到提升,人流吸管的清洗合格率明显提高。

  8. 角质细胞生长因子联合粒细胞集落刺激因子对5.0 Gy照射小鼠造血及免疫系统的保护作用%Protective effect of G-CSF and KGF on hematopoietic and immune system mice irradiated with 5.0 Gy γ-ray

    Institute of Scientific and Technical Information of China (English)

    于程程; 张鹏程; 邢志伟; 沈秀; 王小春; 赵欣然; 李进; 郝建秀; 吴红英

    2013-01-01

    目的 本文研究角质细胞生长因子(KGF)联合粒细胞集落刺激因子(G-CSF)对急性放射病小鼠造血及免疫系统的保护作用.方法 以6~8周龄C57BL/6小鼠为研究对象,经137Cs-γ射线一次性全身照射后,通过体重、脏器系数、外周血常规(WBC、RBC、Hb、PLT)、股骨有核细胞数(BMNC)、骨髓DNA含量、脾结节数(CFU-S)等指标检测其对受照小鼠血液、造血及免疫系统的影响.结果 不同给药组对辐射小鼠造血及免疫系统均有一定的保护作用.联合组的体重恢复情况明显好于其他各组;与单纯IR组比较,联合组的胸腺系数差异有统计学意义(P<0.05)、脾系数有统计学差异(P<0.01);联合组的WBC(P <0.05)、RBC(P <0.05)、Hb(P<0.01)、PLT(P <0.01)差异有统计学意义;联合组的BMNC、骨髓DNA含量、CFU-S均有统计学差异(P<0.01).结论 本研究表明KGF联合G-CSF对辐射损伤小鼠有一定疗效.%Objective To study the protection of hematopoietic and immune system on acute radiation sickness in mice with combined KGF + G-CSF.Methods C57BL/6 mice of 6-8 weeks were selected to receive whole body irradiation of γ-ray,through body weights,organ indexes,white blood cells,red blood cells,blood platelets and concentration of hemoglobin in peripheral blood,bone marrow nucleated cells,bone marrow DNA contents,colony forming units of spleen,to detect its effect on blood,hematopoietic and immune system in irradiated mice.Results Administered by different groups for irradiated mice in hematopoietic and immune system had a protective effect.The weight restoration of combined group was significantly better than other groups; Compared with simple IR group,difference of combined group with thymus index had statistically significant (P < 0.05),spleen index had significant difference (P<0.01) ;Combined group with WBC (P <0.05),RBC (P <0.05),Hb (P <0.01),PLT (P < 0.01) had statistically significant; Combined group with BMNC,bone marrow DNA and CFU-S had all significant difference (P <0.01).Conclusions KGF in combination with C-CSF is of certain protective effect for radiation injury in C57BL/6 mice.

  9. East Meets West: Rome. Grade 6 Model Lesson for Unit V. California History-Social Science Course Models.

    Science.gov (United States)

    Zachlod, Michelle, Ed.

    This unit for sixth-grade students provides a fuller understanding of Julius Caesar's significance. Before students delve into the sample topic, they need an understanding of Roman values, lore, republican ideals, and structure of early Roman history. The first few activities in this lesson are to be taught prior to beginning the actual study of…

  10. The Rosenberg Trial: Uncovering the Layers of History

    Science.gov (United States)

    Ragsdale, Bruce A.

    2013-01-01

    The trial of Julius and Ethel Rosenberg on charges of conspiring to spy for the Soviet Union remains one of the defining moments of the Cold War era. The dramatic allegations of stolen atomic secrets and networks of Communist spies riveted the public's attention. The determination of government prosecutors reflected a widely shared belief that the…

  11. Vermilion Harbor, Ohio. Detailed Project Report on Section 111, Shore Erosion Study. Stage 3 Documentation

    Science.gov (United States)

    1982-09-01

    Jean Lee Helen Bell Arline P. Ford Anne R. Turner Frank J. Lee Martha H. Keith Ronald Guy Hetche Ruth E. Partington Nancy Rothlmn Mark Magnotto Thomas...trs. G. R. Thompson Ruth E. Peterka Herbert Woods Julius A. Moes George W. Grossman F. F. Peterka Jane Hetche IOf 4 dL DEPARTMENT OF THE ARMY BUFFALO

  12. Eesti tööõpetuse alustalad / Endel Rihvk

    Index Scriptorium Estoniae

    Rihvk, Endel

    2005-01-01

    Lühiülevaade Eesti tööõpetuse õpetamisest ja suurkujudest: Eugen Bachblum, Villu Bauman, Agu Jaanson, August Kõrbe, Endel Land, Elmar Meiorg, Sergei Menshikov, Arseni Mölder, Geenart Nagel, Hans Niit, Arseni Reinumäe, Hugo Saaremets, Oleg Tefanov, Lembit Toome, Enno Toost, Julius Ungru, Priidu Valk, Ravo Vasari, Uno Vellomäe

  13. The Monk's Tale: Nero's Nets and Caesar's Father -- An Inquiry into the Transformations of Classical Roman History in Medieval Tradition

    Science.gov (United States)

    Waller, Martha S.

    1978-01-01

    Discusses the lack of consistent accuracy about historical figures in Chaucer's "Monk's Tale." The story of Nero fishing in the Tiber with golden nets is corroborated by many other ancient and medieval authors; however, the reference to Julius Caesar as being of lowly birth is peculiar only to Chaucer and a few medieval English authors.…

  14. South Africa: ANC Youth League President issues apology following conviction for hate speech.

    Science.gov (United States)

    Thomas, Shalini

    2011-10-01

    In June 2011, fifteen months after he had been found guilty of hate speech and discrimination, African National Congress (ANC)Youth President Julius issued a formal apology and agreed to pay a R50,000 (CAN$7,120) fine that was part of the conviction.

  15. The CSIR contribution to the Revision of the SA Road Pavement Design Method (SAPDM)

    CSIR Research Space (South Africa)

    Maina, J

    2012-10-01

    Full Text Available ? Connell Mr Robert Leyland Ms Amrita Maharaj Mr Willy Diederiks Mr Colin Fisher Mr Julius Komba Mr Tso Nkgapele Mr Zweli Mthembu Ms Ellen Laubscher Ms Rianie Castelyn Mr Dave Ventura Mr Georges Mturi Ms Kele Makamu Ms Keneilwe Mogonedi Ms...

  16. Ühe Eduard Wiiraltiga seotud eksituse jälil / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2008-01-01

    Eduard Wiiralti 1930. aastal tehtud eksliibrisest, mille Julius Genss omistas väljaandes "Kunsti album II" (1935) ekslikult Samuel Nellinile. Tegelik omanik on metallikunstnik Samuel Yellin (1885-1940), mille tegi kindlaks Mai Levin ("Eduard Wiiralt", 1998). Lühiülevaade Samuel Yellini elust ja tegevusest

  17. "Die Young 2" - tegelikult mitte eriti õppefilm / Maris Meiessaar

    Index Scriptorium Estoniae

    Meiessaar, Maris

    2007-01-01

    Tervise Arengu Instituudi algatusel valminud õppefilm HIV-viiruse ohtudest ja aidsist "Sure noorelt" : stsenarist Asko Künnap : Chalice'i, Sten Sheripovi ja Röövel Ööbiku muusika : osades Nele Kirsipuu, Julius Seljamaa : Eesti 2007

  18. Evaluation and Repair of Concrete Slabs

    Science.gov (United States)

    1992-01-01

    Orville R. Werner Paul H. Karr ’ Robert E3. Philkeo Zenon A. Zielinski Lawrence 1. Knab Mtlos Poltvka Corresponding members Alfred G. Btshara J. P. Lloyd...Robert L. Yuan’ Consulting members Julius G. Potyondy Ernest K. Schrader Raymond J. Schutz ’* iortat auihor ( ot inhut ink ithor. F-orme’r commiittece

  19. Silmapaistvaid metsateadlasi Tallinnas 20. sajandi esimesel poolel / Malev Margus

    Index Scriptorium Estoniae

    Margus, Malev, 1923-2014

    1996-01-01

    Julius Kitsing; Jaan Hellat; Aleksander Pals; Arnold Merihein; Voldemar Mathiesen; Bernhard Tuskvere; Kaljo Sotter; Vassili Mutt, Jaan Luik; Aleksander Raukas; Valdur Küng; Nikolai Küttis; Viktor Obet; Jakob Visnapuu; Karl Keerdoja; Edgar Vester. Lühiandmeid. Kokkuv. ingl. k.

  20. Culture Wars in Denmark

    DEFF Research Database (Denmark)

    Ørum, Tania

    2016-01-01

    In the 1960s high and low culture were brought into sharp conflict i Denmark. In 1961 a Ministry of Culture was established for the first time. The first minister of culture, the social democrat Julius Bomholt, saw art and culture as an important part of education for democracy that should be made...

  1. Command History for 1991 (Naval Personnel Research and Development Center)

    Science.gov (United States)

    1992-08-01

    Awards 35 Years Ben Garcia Gene Stout 30 Years Jim Julius Ramona Mouzon Hal Rosen 32 25 Years Jim Chadbourne Bob Harris Dorothy Martin Jan Reynolds 20...Years Craig Borland* Mike Flaningam 15 Years Mark Chipman Carmen Fendelman Murray Rowe 10 Years James Apple Jessie Grier Ana Guerrero* Loralee Hartmann

  2. Liquid crystal colloids

    Directory of Open Access Journals (Sweden)

    2010-01-01

    Full Text Available This special issue of "Condensed Matter Physics" focuses on the most recent developments in the study of a fascinating soft matter system, representing colloidal particles in a liquid crystalline environment. Furthermore, some articles address pioneering steps in the discovery of liquid crystals going back to 1861 paper by Julius Planer.

  3. Peterburi Jaani kirik = St. John's church in St. Petersburg, Russia / Juta Lember ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Lember, Juta, 1943-

    2012-01-01

    Lühidalt Dekabristide t. 54A asuva Peterburi Jaani kiriku ajaloost (arhitektid Karl Ziegler, Harald Julius von Bosse, 1860), kiriku uuest interjöörist. Kiriku sisearhitekt Juta Lember pälvis Eesti Kultuurkapitali 2011. aasta aastapreemia vaimselt ja arhitektuurselt nõudliku ruumitüübi meisterliku ja tänapäevase käsitluse eest

  4. Elegijas Baltijas veju pavadijuma / Guntars Godinsh

    Index Scriptorium Estoniae

    Godiņš, Guntars, 1958-

    2002-01-01

    Detsembris 2001 Läti Suursaatkonnas toimunud kirjandusõhtust, kus esitleti Ivar Ivaski neljakeelset luuleraamatut: Ivask, Ivar. Baltijas elegijas = The Baltic elegies = Balti eleegiad = Baltiskos elegijos / tõlkijad: Valters Nollendorfs, Paul-Eerik Rummo, Julius Keleras. Riga : Petergailis, 2001

  5. Shakespeare among Schoolchildren: Approaches for the Secondary Classroom.

    Science.gov (United States)

    Rygiel, Mary Ann

    Making connections for teachers between Shakespeare and his historical context on the one hand and secondary students on the other, this book presents background information, commentary, resources, and classroom ideas to enliven students' encounters with Shakespeare. The book concentrates on "Romeo and Juliet,""Julius Caesar,""Macbeth," and…

  6. Eesti tööõpetuse alustalad / Endel Rihvk

    Index Scriptorium Estoniae

    Rihvk, Endel

    2005-01-01

    Lühiülevaade Eesti tööõpetuse õpetamisest ja suurkujudest: Eugen Bachblum, Villu Bauman, Agu Jaanson, August Kõrbe, Endel Land, Elmar Meiorg, Sergei Menshikov, Arseni Mölder, Geenart Nagel, Hans Niit, Arseni Reinumäe, Hugo Saaremets, Oleg Tefanov, Lembit Toome, Enno Toost, Julius Ungru, Priidu Valk, Ravo Vasari, Uno Vellomäe

  7. Rehabilitation of Platanista gangetica (Lebeck, 1801) as the valid scientific name of the Ganges dolphin

    NARCIS (Netherlands)

    Kinze, C.C.

    2000-01-01

    The Dutch scientist Heinrich Julius Lebeck’s description of the Ganges dolphin is, based on a deduced latest date of publication 24 August 1801, given priority over William Roxburgh’s account of the same species, for which no precise date could be established. Although very similar to the work of

  8. Ühe Eduard Wiiraltiga seotud eksituse jälil / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2008-01-01

    Eduard Wiiralti 1930. aastal tehtud eksliibrisest, mille Julius Genss omistas väljaandes "Kunsti album II" (1935) ekslikult Samuel Nellinile. Tegelik omanik on metallikunstnik Samuel Yellin (1885-1940), mille tegi kindlaks Mai Levin ("Eduard Wiiralt", 1998). Lühiülevaade Samuel Yellini elust ja tegevusest

  9. Reframing Alice's Restaurant: Reflections on Globalisation, Adult Education, and Transformative Learning

    Science.gov (United States)

    Etmanski, Catherine

    2005-01-01

    In the mid-1960s, the foundations of Participatory Research were being laid in Tanzania and around the world through the work of muckraking adult educators--President Julius Nyerere, Marja-Liisa Swantz, Orlando Fals Borda, Rajesh Tandon, Budd Hall and many more of their friends and colleagues. At the same time, a bunch of American kids were over…

  10. Veel Dora Gordine'ist / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2006-01-01

    Skulptor Dora Gordine'ist (Gordin, Gordina), tema kohta leiduvast infost (Julius Genss, Leo Gens, Ervin Pütsep, K. G. Sauri "The Artists of the World", H. Vollmeri "Allgemaines Lexikon der bildenden Künstler"), esinemisest näitustel Eestis. Vt. ka: Kivimäe, Juta. Dora Gordini teekond suurde kunsti algas Tallinnast // Sirp, 2006, 25. august, lk. 10

  11. East Meets West: Rome. Grade 6 Model Lesson for Unit V. California History-Social Science Course Models.

    Science.gov (United States)

    Zachlod, Michelle, Ed.

    This unit for sixth-grade students provides a fuller understanding of Julius Caesar's significance. Before students delve into the sample topic, they need an understanding of Roman values, lore, republican ideals, and structure of early Roman history. The first few activities in this lesson are to be taught prior to beginning the actual study of…

  12. Willingness to Communicate and Action Control

    Science.gov (United States)

    MacIntyre, Peter D.; Doucette, Jesslyn

    2010-01-01

    Being willing to communicate is part of becoming fluent in a second language, which often is the ultimate goal of L2 learners. Julius Kuhl's theory of action control is introduced as an expansion of the conceptual framework for the study of Willingness to Communicate. Kuhl proposed three key concepts, preoccupation, volatility, and hesitation,…

  13. Pilkupüüdev seltsidaam / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2006-01-01

    Shoti päritolu näitlejanna Lindsay Duncan, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesari kättemaksuhimulist armukest Serviliat. Sama ka : Teleleht nr. 50, lk.38 : ill

  14. 16. oktoobril 2005 Kõik valima! : [luuletused

    Index Scriptorium Estoniae

    2005-01-01

    Sisu: Inna Feldbach. "Tegin vahtralehdedele põletusmatust..." ; Katrin Väli. Ülesanne: vrais ou faut ; Karl Martin Sinijärv. Monkey Doodle ehk Kommarid? Kahju... ; Andra Teede. Suurte siniste silmade maa ; Tiina Saar. Valijale ; Kohutav keskerakohuke / tundmatu netifolklorist ; Julius Ürt. Etteütlus

  15. Book Reviews

    Directory of Open Access Journals (Sweden)

    Joann Kovacich

    2013-09-01

    Osage, Patricia and McCall, Mary. Connecting with Socially Isolated Seniors: A Service Provider’s Guide Diane L. Brown Lynch, Caitrin. My Name is Julius: a film about growing old, staying young, and confronting a lifetime of hearing loss Lynch, Caitrin. Retirement on the Line : Age, Work, and Value in an American Factory Anne Velardi

  16. Peterburi Jaani kirik = St. John's church in St. Petersburg, Russia / Juta Lember ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Lember, Juta, 1943-

    2012-01-01

    Lühidalt Dekabristide t. 54A asuva Peterburi Jaani kiriku ajaloost (arhitektid Karl Ziegler, Harald Julius von Bosse, 1860), kiriku uuest interjöörist. Kiriku sisearhitekt Juta Lember pälvis Eesti Kultuurkapitali 2011. aasta aastapreemia vaimselt ja arhitektuurselt nõudliku ruumitüübi meisterliku ja tänapäevase käsitluse eest

  17. Shakespeare: Kabuki-Style.

    Science.gov (United States)

    Turse, Paul Leonard, Jr.

    This study examines the theatrical and thematic aspects of Kabuki and provides recommendations for using these aspects in the production of plays by Shakespeare. Sequences from "Hamlet,""Macbeth," and "Julius Caesar" were chosen because they are adaptable to Kabuki design. In order to help a director view these plays…

  18. African Philosophy of Education: Analysis of the Neglected Ideals of Nyerere's Ujamaa

    Science.gov (United States)

    Mukhungulu, Maira Justine; Kimathi, Vengi Ambrose; K'Odhiambo, Atieno Kili

    2017-01-01

    The ideals of education in Ujamaa philosophy as enunciated by Julius Kambarage Nyerere, the founding president of Tanzania, are neglected phenomena in African education. In about fifty decades of offering education in Africa, from the end of colonialism to the present, education has not enabled Africans to be self-reliant and to live peacefully as…

  19. KGB, Stasi ja Eesti luureajalugu / Ivo Juurvee

    Index Scriptorium Estoniae

    Juurvee, Ivo, 1979-

    2008-01-01

    Väidetest Saksa luure koostöö kohta Balti riikidega 1930ndatel aastatel. Nende väidete algallikatest ja paikapidavusest. Nimetatud väidete teaduskäibesse toojast Leonid Barkovist ja Barkovi väidete levitajatest ajalookirjanduses Edgar Siegfried Meosest ning Julius Maderist. Paljukorratud väidete usaldusväärseiks pidamise ohust

  20. Kaunid koorikud / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2005-01-01

    Puidust sõrestikkoorikute ehitamisest Euroopas. Sõrestikkoorikust Mannheimis (Frei Otto, 1975). Weald and Downland'i vabaõhumuuseumi uuest abihoonest (Edward Cullinan Architects, 2002) Suurbritannias. EXPO paviljonist Hannoveris (Herzog [Thomas Herzog] & Partnerid, insener Julius Natterer, 2000). 5 värv. ill

  1. On the Scope of Justice: In Defence of the Political Conception

    DEFF Research Database (Denmark)

    Midtgaard, Søren Flinch

    2012-01-01

    The paper defends the so-called political conception of the scope of justice proposed by Thomas Nagel. The argument has three stages: (a) I argue that A. J. Julius’ infl uential criticism of the political conception can be answered. Pace Julius, actual and (relevant) hypothetical cases of state...

  2. Kaunid koorikud / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2005-01-01

    Puidust sõrestikkoorikute ehitamisest Euroopas. Sõrestikkoorikust Mannheimis (Frei Otto, 1975). Weald and Downland'i vabaõhumuuseumi uuest abihoonest (Edward Cullinan Architects, 2002) Suurbritannias. EXPO paviljonist Hannoveris (Herzog [Thomas Herzog] & Partnerid, insener Julius Natterer, 2000). 5 värv. ill

  3. Tee Toompealt Pääskülani ja Tallinna saras / Tõnu Raid

    Index Scriptorium Estoniae

    Raid, Tõnu, 1939-

    2009-01-01

    Keskaegses Tallinnas puudus maamõõtja. Esimese säilinud Tallinna linnaplaani valmistas 1680. aastal Tallinna gümnaasiumi professor Heinrich Julius Woltemate. 1807. aastal loodi linna maamõõtja koht. Kõrgepea nuki asukohast. Pärnu maanteest esimestel kaartidel. Pärnu maantee üleviimisest. Muinasaja teest Pääskülast Tallinna.

  4. Educators Weigh E-Textbook Cost Comparisons

    Science.gov (United States)

    Tomassini, Jason

    2012-01-01

    During the first-ever Digital Learning Day, U.S. Secretary of Education Arne Duncan and Federal Communications Commission chief Julius Genachowski unveiled an ambitious plan earlier this year to get schools to switch from print to digital textbooks by 2017. Dubbed the Digital Textbook Playbook, it's a recommendation for how schools could transform…

  5. Rehabilitation of Platanista gangetica (Lebeck, 1801) as the valid scientific name of the Ganges dolphin

    NARCIS (Netherlands)

    Kinze, C.C.

    2000-01-01

    The Dutch scientist Heinrich Julius Lebeck’s description of the Ganges dolphin is, based on a deduced latest date of publication 24 August 1801, given priority over William Roxburgh’s account of the same species, for which no precise date could be established. Although very similar to the work of Ro

  6. Veel Dora Gordine'ist / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2006-01-01

    Skulptor Dora Gordine'ist (Gordin, Gordina), tema kohta leiduvast infost (Julius Genss, Leo Gens, Ervin Pütsep, K. G. Sauri "The Artists of the World", H. Vollmeri "Allgemaines Lexikon der bildenden Künstler"), esinemisest näitustel Eestis. Vt. ka: Kivimäe, Juta. Dora Gordini teekond suurde kunsti algas Tallinnast // Sirp, 2006, 25. august, lk. 10

  7. A survey of Attacks on VoIP networks and Countermeasures

    African Journals Online (AJOL)

    PROF. OLIVER OSUAGWA

    2015-06-01

    Jun 1, 2015 ... Julius N. Obidinnu 1 and Ayei E. Ibor ... convergence of the voice and data networks pose a plethora of threats to ... insight into the unpredictable nature of ..... "Security analysis and countermeasures assessment against spit ... Artificial Intelligence, Management Science and Electronic Commerce (AIMSEC),.

  8. Pilkupüüdev seltsidaam / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2006-01-01

    Shoti päritolu näitlejanna Lindsay Duncan, kes kehastab ajaloolises teleseriaalis "Rooma" (tootjad Ameerika HBO, inglaste BBC ja itaallaste RAI) Gaius Julius Caesari kättemaksuhimulist armukest Serviliat. Sama ka : Teleleht nr. 50, lk.38 : ill

  9. De helm van BEKON : legionair onder Caesar?

    NARCIS (Netherlands)

    Hupperetz, W.

    2015-01-01

    The inscription in Iberian script and the name indicate that legionary Bekon was from one of the Spanish provinces. We know that Julius Caesar as governor of Hispania Ulterior (Southern Spain) put together a legion in this Spanish province (the tenth) in 61 BC. That was one of the legions that he

  10. Danmarksruder

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    2005-01-01

    at udtale entydige offentlige budskaber (Ortega y Gasset, Clement Greenberg) blev i efterkrigstiden brugt som frihedsemblem, en tendens, der også spores i Rudes landskaber, der af den socialdemokratiske undervis­nings­minister Julius Bomholt og Ny Carlsbergfondets direkte Viggo Thorlacius- Ussing blev...

  11. Shakespeare on Film in the Classroom.

    Science.gov (United States)

    Mullin, Michael

    A course at the University of Illinois entitled "Shakespeare on Film" is discussed briefly, and an annotated list of Shakespeare films for the classroom teacher is provided in this paper. Thirteen films are listed: three versions of "Hamlet,""Henry V,""Julius Caesar," four versions of "Macbeth,""A Midsummer Night's Dream,""Othello,""Romeo and…

  12. Scholarly Appraisals of Literary Works Taught in High Schools.

    Science.gov (United States)

    Dunning, Stephen, Ed.; Sams, Henry W., Ed.

    Critical essays on eight literary works--four from the conventional literature curriculum and four less widely taught--are collected in this publication. Each o f the four standard selections--"Great Expectations,""Julius Caesar,""The Scarlet Letter," and "Macbeth"--is treated in two essays and a bibliography; and each of the less widely taught…

  13. Distorting the Past

    Science.gov (United States)

    Klehr, Harvey

    2004-01-01

    Many historians on the left are unwilling to renounce communism and the agents in this country who ran its insidious errands. Despite damning evidence from Soviet archives, Julius and Ethel Rosenberg, Alger Hiss, and other traitors remain the darlings of many leaders of the profession. Harvey Klehr documents how, in journals and recent textbooks,…

  14. Theoretical Developments in SUSY

    Science.gov (United States)

    Shifman, M.

    2009-01-01

    I am proud that I was personally acquainted with Julius Wess. We first met in 1999 when I was working on the Yuri Golfand Memorial Volume (The Many Faces of the Superworld, World Scientific, Singapore, 2000). I invited him to contribute, and he accepted this invitation with enthusiasm. After that, we met many times, mostly at various conferences in Germany and elsewhere. I was lucky to discuss with Julius questions of theoretical physics, and hear his recollections on how supersymmetry was born. In physics Julius was a visionary, who paved the way to generations of followers. In everyday life he was a kind and modest person, always ready to extend a helping hand to people who were in need of his help. I remember him telling me how concerned he was about the fate of theoretical physicists in Eastern Europe after the demise of communism. His ties with Israeli physicists bore a special character. I am honored by the opportunity to contribute an article to the Julius Wess Memorial Volume. I will review theoretical developments of the recent years in non-perturbative supersymmetry.

  15. Theoretical developments in SUSY

    Energy Technology Data Exchange (ETDEWEB)

    Shifman, M. [University of Minnesota, William I. Fine Theoretical Physics Institute, Minneapolis, MN (United States)

    2009-01-15

    I am proud that I was personally acquainted with Julius Wess. We first met in 1999 when I was working on the Yuri Golfand Memorial Volume (The Many Faces of the Superworld, World Scientific, Singapore, 2000). I invited him to contribute, and he accepted this invitation with enthusiasm. After that, we met many times, mostly at various conferences in Germany and elsewhere. I was lucky to discuss with Julius questions of theoretical physics, and hear his recollections on how supersymmetry was born. In physics Julius was a visionary, who paved the way to generations of followers. In everyday life he was a kind and modest person, always ready to extend a helping hand to people who were in need of his help. I remember him telling me how concerned he was about the fate of theoretical physicists in Eastern Europe after the demise of communism. His ties with Israeli physicists bore a special character. I am honored by the opportunity to contribute an article to the Julius Wess Memorial Volume. I review theoretical developments of the recent years in non-perturbative supersymmetry. (orig.)

  16. "Die Young 2" - tegelikult mitte eriti õppefilm / Maris Meiessaar

    Index Scriptorium Estoniae

    Meiessaar, Maris

    2007-01-01

    Tervise Arengu Instituudi algatusel valminud õppefilm HIV-viiruse ohtudest ja aidsist "Sure noorelt" : stsenarist Asko Künnap : Chalice'i, Sten Sheripovi ja Röövel Ööbiku muusika : osades Nele Kirsipuu, Julius Seljamaa : Eesti 2007

  17. 78 FR 7780 - Sunshine Act Meeting; FCC Announces Further Details for the First Post-Superstorm Sandy Field...

    Science.gov (United States)

    2013-02-04

    ...In the wake of Superstorm Sandy, Federal Communications Chairman Julius Genachowski announced plans to convene a series of field hearings to examine challenges to the nation's communications networks during natural disasters and in other times of crisis. The first hearing will facilitate a wider national dialogue about the resiliency of communications networks by focusing on the impact of......

  18. Rehabilitation of Platanista gangetica (Lebeck, 1801) as the valid scientific name of the Ganges dolphin

    NARCIS (Netherlands)

    Kinze, C.C.

    2000-01-01

    The Dutch scientist Heinrich Julius Lebeck’s description of the Ganges dolphin is, based on a deduced latest date of publication 24 August 1801, given priority over William Roxburgh’s account of the same species, for which no precise date could be established. Although very similar to the work of Ro

  19. Attend the lecture of the first artist-scientist inspiration partners of the Collide@CERN programme

    CERN Multimedia

    2012-01-01

    Julius Von Bismarck, the first winner of the Prix Ars Electronica Collide@CERN residency award for the digital arts and his science inspiration partner, Dr. James Wells, will present their individual work in art and science at the beginning of the residency on Wednesday 21 March at 18:45 at the Globe of Science and Innovation.   Hands up, this is a photo shoot! Julius Von Bismarck in action. All are welcome! The event will be in English, the common language between the artist and the scientist. To make a reservation for you and any guests, please send an e-mail to merce.monje.cano@cern.ch or call +41 22 76 75 246. For the complete programme of the event, see the official invitation.

  20. Direct and indirect speech fusion in Charisius’ Ars grammatica

    Directory of Open Access Journals (Sweden)

    Marcos Antonio Pérez Alonso

    2012-06-01

    Full Text Available When transmitting the teaching of his predecessors, the grammarian Charisius usually makes use of either subordinating clauses or direct speech, but he hardly ever employs the so-called indirect speech, typically found in strictly literary works rather than in technical ones. However, we have encountered some passages in which portions in direct speech precede indirect speech clauses, a remarkable phenomenon which could be thought of as textual corruptions needing emendation. Nevertheless, from the fact that this phenomenon is mainly found in parts of Charisius’ work taken from Julius Romanus’ De analogía (where the latter quotes Pliny the Elder’s Dubius sermo, we conclude that the text is correct and that we are dealing with a type of citation characteristic of Julius Romanus, the description of which is not found in the literature on Latin Syntax.

  1. A Study to Develop an Improved Organizational Structure for the Provision of Administrative Support for the Delivery of Health Care at Fitzsimons Army Medical Center

    Science.gov (United States)

    1978-05-01

    composite of tested , effective organizational concepts capable of providing improved service to the clinical staff." 2 Finally, an alterna- tive structure...Dugway Proving Grounds is a DARCOM installation primarily involved with munitions testing . The - 30 clinic, previously a MEDDAC with inpatient...Medicine, 6 March 1978; Colonel (Dr.) Julius T. Coggin , MC, De- partment of Pathology and Area Laboratory Services, 3 February 1978; 54 Colonel (Dr

  2. Water Scarcity: A Selected Bibliography

    Science.gov (United States)

    2011-06-01

    York: United Nations University Press, 2008. 313pp. (HD1691 .I54 2008) Parry, M. L., et al., eds. Climate Change 2007: Impacts , Adaptation and...12 Mangisoni, Julius H. " Impact of Treadle Pump Irrigation Technology on Smallholder Poverty and Food Security in Malawi: A Case Study of Blantyre...Suvarna, Shreevani. "Development Aid in an Environmental Context: Using Microfinance to Promote Equitable and Sustainable Water Use in the Nile Basin

  3. A Study of Computational Techniques Related to Prediction of Centroids of Dosage Beyond Measured Time Tn Where n is Known.

    Science.gov (United States)

    2014-09-26

    Mathematical Methods for Physicists and Engineers. Reinhold Book Corporation, 199Ŝ. Conover, W.J. Practical Nonparametric Statistics. John Wiley and Sons, N.Y...Julius R., Rosenblatt, Judah. Probability and Statistics, W. B. Saunders Co.,1972. Boas, R.P. The American Mathematical Monthly , Vol. 88, No. 3...Addison- Wesley, Reading, Mass., 1970. Kenney, J.F. and Keeping, E.S. Mathematics of Statistics- Part One. D. Van Nostrand Co., Inc., 1954. *Korn, Granino

  4. Flapping Wing Flight Dynamic Modeling

    Science.gov (United States)

    2011-08-22

    von Karman, T. and Burgers, J. M., Gerneral Aerodynamic Theory - Perfect Fluids , Vol. II, Julius Springer , Berlin, 1935. [24] Pesavento, U. and Wang...L., Methods of Analytical Dynamics , McGraw-Hill Book Company, New York, 1970. [34] Deng, X., Schenato, L., Wu, W. C., and Sastry, S. S., Flapping...Micro air vehicle- motivated computational biomechanics in bio ights: aerodynamics, ight dynamics and maneuvering stability, Acta Mechanica

  5. Proyectar desde la imagen: la fotografía como instrumento creador de atmósferas construidas en la obra de Druot, Lacaton y Vassal

    OpenAIRE

    Luzarraga-Iturrioz, A. (Arantzazu)

    2016-01-01

    Lacaton & Vassal, in collaboration with Frédéric Druot were commissioned to upgrade 1960s and 1970s residential high rise developments in the banlieues of Paris. Based on the ‘never demolishing, subtracting or replacing things, but always adding, transforming and utilising them’ premise, the authors’ used a threestep procedure in which photography played a major role. The process starts with some images taken by photographer Julius Shulman in the Case Study House #22 by Pierre Koe...

  6. Female-targeted drug therapies may propel migraine DM efforts.

    Science.gov (United States)

    1998-02-01

    Julius Caesar, Thomas Jefferson, and even Sigmund Freud had this ailment, and Alice is thought to have described it in Wonderland. But make no mistake, migraine headaches are not the stuff of fairy tales for the 45 million migraine sufferers of the disabling and costly disorder. Here are the disease management guidelines you need to reduce migraine-related expense and minimize your patient's pain.

  7. Defining and Demonstrating Capabilities for Experience-Based Narrative Memory

    Science.gov (United States)

    2011-07-01

    missing and elided information in the story. For example, given a brief synopsis of Shakespeare’s Macbeth plot, the Genesis system can fill in the...results of certain actions, such as that “if Ducan kills Macbeth , Macbeth is dead.” This information was then fed into the Analogical Story Merging (ASM...notes the detailed similarities of Macbeth and Hamlet, how Julius Caesar shares some structure with Macbeth and Hamlet but nowhere near as much, and

  8. Factors influencing exacerbation-related self-management in patients with COPD: a qualitative study

    OpenAIRE

    Korpershoek YJG; Vervoort SCJM; Nijssen LIT; Trappenburg JCA; Schuurmans MJ

    2016-01-01

    YJG Korpershoek,1,2 SCJM Vervoort,3 LIT Nijssen,2 JCA Trappenburg,2 MJ Schuurmans1,2 1Research Group Chronic Illnesses, Faculty of Health Care, University of Applied Sciences Utrecht, 2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3Cancer Center, University Medical Center Utrecht, Utrecht, the Netherlands Background: In patients with COPD, self-management skills are important to reduce the impact of exacerbations. However, both detection and adequate...

  9. Piracy and its relationship to international law

    OpenAIRE

    Štemberg, Milan

    2010-01-01

    Résumé Piracy and its Relation to the International Law Piracy is a threat to maritime navigation - and to maritime trade in particular - that is as ancient as maritime navigation itself. Even the Roman ruler Julius Caesar was - according to historians - captured by the pirates and released only after paying a royal ransom. At the beginning of the twentieth century, some authors considered the crime of piracy to be 'obsolete'. However, as the latest development proves, piracy is unfortunately...

  10. Muulane või surmasõlm / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2007-01-01

    Tutvustus: Ivinskaja, Olga. Aastad Boriss Pasternakiga, ehk, Aja vangis / tlk. Vilma Matsov. Tallinn : Varrak, 2006 ; Baranov, Vadim. Maksim Gorki. Elu ja surma saladus / tlk. Jüri Pärni. Tallinn : Kunst, 2006 ; Troyat, Henri. Aleksander III : lumetsaar / tlk. Jana Porila. Tallinn : Eesti Raamat, 2006 ; Runnel, Hando. Viru veri ei värise. [Tartu] : Ilmamaa, 2006 ; Pärnik, Ylo M. Dr. Julius von Scultz-Bertram. Tartu : Ilmamaa, 2006

  11. How Have Deployments During the War on Terrorism Affected Reenlistment?

    Science.gov (United States)

    2009-01-01

    theory of planned behavior in social psychology ( Ajzen , 1985, 1991). In this formulation, the individual has behavioral beliefs about the...2007-001, 2007. Ajzen , Icek, “From Intentions to Actions: A Theory of Planned Behavior ,” in Julius Kuhl and Jürgen Beckmann, eds., Action Control: From...Cognition to Behavior , Berlin: Springer, 1985. ———, “The Theory of Planned Behavior ,” Organizational Behavior and Human Decision Processes,

  12. On the origin of the cosmic elements and the nuclear history of the universe

    Science.gov (United States)

    José, Jordi; Asplund, Martin; Charbonel, Corinne; Cherchneff, Isabelle; Diehl, Roland; Korn, Andreas; Thielemann, Friedrich-Karl

    2016-08-01

    The quest for the energy source of stars, capable of maintaining their long-lasting brightness, has puzzled physicists during centuries. Early suggestions, due to Julius R. von Mayer, John James Waterson, Hermann von Helmholtz, and William Thomson (Lord Kelvin), among others, relied on the conversion of gravitational potential energy into heat. However, the age of the Sun inferred in this framework was only a few million years, a value clearly at odds with estimates based on geological records.

  13. In Vivo Osteoinductive Effect and In Vitro Isolation and Cultivation Bone Marrow Mesenchymal Stem Cells

    OpenAIRE

    Redžić, Amira; Smajilagić, Amer; Aljičević, Mufida; Berberović, Ljubomir

    2010-01-01

    Bone marrow contains cell type termed Mesenchymal Stem Cells (MSC), first recognized in bone marrow by a German pathologist, Julius Cohnheim in 1867. That MSCs have potential to differentiate in vitro in to the various cells lines as osteoblast, chondroblast, myoblast and adipoblast cells lines. Aims of our study were to show in vivo capacity of bone marrow MSC to produce bone in surgically created non critical size mandible defects New Zeeland Rabbits, and then in second part of study to iso...

  14. Is Pakistani Equity Market Integrated to the Equity Markets of Group of Eight (G8) Countries? An Empirical Analysis of Karachi Stock Exchange

    OpenAIRE

    Syed Muhammad Aamir Shah; Muhammad Husnain; Ashraf Ali

    2012-01-01

    This study looks at the dynamic relationship between the Pakistani equity market and equity markets of Group of Eight countries (G8) which includes Canada, France, Germany, Italy, Japan, Russia, UK and USA by using weekly time series data starting from June 2004 to May 2009. Multivariate Co-integration approach by Johnson and Julius (1990) shows there exists no long-term relationship between the G8 and Pakistani equity market. Vector error correction (VECM) model suggests that 100% of the lag...

  15. Area Handbook Series: Egypt: A Country Study

    Science.gov (United States)

    1991-01-01

    Ptolemaic pharaohs and endured until the suicide of Cleopatra in 30 B.C., at which time direct Roman control was instituted. The early Ptolemies were...Idfu) and Den- ,Ata (present-day Dandarah). The last of the Ptolemies was Cleopatra , the wife of Julius Cae- sar and later Mark Antony. During her...reign, Egypt again became a factor in Mediterranean politics. Cleopatra was a woman of genius and a worthy opponent of Rome. Her main preoccupations were

  16. La transformación de Víctor Frankenstein desde el modelo actancial de Greimas

    OpenAIRE

    2013-01-01

    El presente artículo analiza al personaje Víctor Frankenstein de la novela "Frankenstein o el moderno Prometeo" de la escritora inglesa Mary Shelley desde el Modelo o esquema actancial postulado por el lingüista francés Algirdas Julius Greimas, con el fin de demostrar la transformación que vive el personaje, antes y después de la creación de su empresa

  17. Differences in pain perception during open muscle biopsy and Bergstroem needle muscle biopsy

    OpenAIRE

    Dengler J; Linke P; Gdynia HJ; Wolf S.; Ludolph AC; Vajkoczy P; Meyer T

    2014-01-01

    Julius Dengler,1 Peter Linke,2 Hans J Gdynia,3 Stefan Wolf,1 Albert C Ludolph,3 Peter Vajkoczy,1 Thomas Meyer2 1Department of Neurosurgery, 2Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany; 3Department of Neurology, Universitätsklinikum Ulm, Ulm, GermanyPurpose: Open surgical muscle biopsy (OB) and percutaneous Bergstroem needle muscle biopsy (NB) are equally accepted procedures. However, there are no data comparing intrapr...

  18. Dicty_cDB: CHC746 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AGKPTQNDVESFFNWIL-- - ---QLIXQLLYELFMQFGY*pynkdiaaaysgxglvanlvqlvktvakekivrlslstlr nllnngksneemidngfvrmlniln...GY*pynkdiaaaysgxglvanlvqlvktvakekivrlslstlr nllnngksneemidngfvrmlnilnikkwgdddipadievlinglakdidnmssfnkykt eii

  19. Radiation-Induced Impairment of Neuronal Excitability

    Science.gov (United States)

    1988-01-01

    population spike. A dose rate of 20 Gy/min shifts to the left the dose response curve for radiation at 5 Gy/min. At 5 Gy/min, significant deficits...postsynaptic damage is likely to result from a different molecular mechanism. 100 , , t 50 0) 000 FIUR 2 6 5 200Radiation Dose (Gy) FIGURE 2 Dose response curve of

  20. Anti-inflammation of the oral mucous after radiotherapy of side effect to the propolis combined effect

    Energy Technology Data Exchange (ETDEWEB)

    Takenori, Yamashita; Gu, Yeunhwa; Park, Sangrae [Suzuka Univ. of Medical Science, Suzuka (Japan)] [and others

    2002-07-01

    Recently, allege acid sodium (AL-G) that affect is proved in the bleeding digestion pipe tumor, the effect on treatment for wound such as a radiation esophagus flame because of the inflammation reduction inside such a mouth is used. Because a tumor and an inflammation are effective, propolis to use for this research is the purpose of examining the anti-inflammation action of the mucous membrane flame in the mouth. The inside of the mouth was made to contain each medicine, and effect on organization repair was examined from the viewpoint of study of the organization. An ICR mail mice used at age of seven weeks. Feed and water were taken freely. As for the experiment group, 2Gy, 4Gy, 8Gy irradiated each of the control group, the oral part separately. Two times gave it 2Gy, 4Gy and 8Gy group, AL-G, a physiology solution of salt, propolis combination thing (Propolis + royal jelly (RJ) +EF2001), PVP in the morning. We used in each groups of 10 mail mice AL-G+2G, AL-G+4GyAL-G+8Gy, Saline+2Gy, Saline+4Gy, Saline+8Gy,Propolis+(RJ+EF2001)+2Gy,Propolis+ (RJ+EF2001)+4Gy,Propolis+(RJ+EF2001)+8Gy, PVP+2Gy, PVP+4Gy and PVP+8Gy groups. It was divided into each group of 2Gy, 4Gy and 8Gy groups from the bottom part of the ear of the ICR mice by the nose head, and it irradiated it once.

  1. Comparison of Different Fractionation Schedules Toward a Single Fraction in High-Dose-Rate Brachytherapy as Monotherapy for Low-Risk Prostate Cancer Using 3-Dimensional Radiobiological Models

    Energy Technology Data Exchange (ETDEWEB)

    Mavroidis, Panayiotis, E-mail: mavroidis@uthscsa.edu [Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, Texas (United States); Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden); Milickovic, Natasa [Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach GmbH, Offenbach (Germany); Cruz, Wilbert F. [Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, Texas (United States); Tselis, Nikolaos [Strahlenklinik, Klinikum Offenbach GmbH, Offenbach (Germany); Karabis, Andreas [Pi-Medical Ltd., Athens (Greece); Stathakis, Sotirios; Papanikolaou, Nikos [Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, Texas (United States); Zamboglou, Nikolaos [Strahlenklinik, Klinikum Offenbach GmbH, Offenbach (Germany); Baltas, Dimos [Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach GmbH, Offenbach (Germany); Nuclear and Particle Physics Section, Physics Department, University of Athens, Athens (Greece)

    2014-01-01

    Purpose: The aim of the present study was the investigation of different fractionation schemes to estimate their clinical impact. For this purpose, widely applied radiobiological models and dosimetric measures were used to associate their results with clinical findings. Methods and Materials: The dose distributions of 12 clinical high-dose-rate brachytherapy implants for prostate were evaluated in relation to different fractionation schemes. The fractionation schemes compared were: (1) 1 fraction of 20 Gy; (2) 2 fractions of 14 Gy; (3) 3 fractions of 11 Gy; and (4) 4 fractions of 9.5 Gy. The clinical effectiveness of the different fractionation schemes was estimated through the complication-free tumor control probability (P{sub +}), the biologically effective uniform dose, and the generalized equivalent uniform dose index. Results: For the different fractionation schemes, the tumor control probabilities were 98.5% in 1 × 20 Gy, 98.6% in 2 × 14 Gy, 97.5% in 3 × 11 Gy, and 97.8% in 4 × 9.5 Gy. The corresponding P{sub +} values were 88.8% in 1 × 20 Gy, 83.9% in 2 × 14 Gy, 86.0% in 3 × 11 Gy, and 82.3% in 4 × 9.5 Gy. With use of the fractionation scheme 4 × 9.5 Gy as reference, the isoeffective schemes regarding tumor control for 1, 2, and 3 fractions were 1 × 19.68 Gy, 2 × 13.75 Gy, and 3 × 11.05 Gy. The optimum fractionation schemes for 1, 2, 3, and 4 fractions were 1 × 19.16 Gy with a P{sub +} of 91.8%, 2 × 13.2 Gy with a P{sub +} of 89.6%, 3 × 10.6 Gy with a P{sub +} of 88.4%, and 4 × 9.02 Gy with a P{sub +} of 86.9%. Conclusions: Among the fractionation schemes 1 × 20 Gy, 2 × 14 Gy, 3 × 11 Gy, and 4 × 9.5 Gy, the first scheme was more effective in terms of P{sub +}. After performance of a radiobiological optimization, it was shown that a single fraction of 19.2 to 19.7 Gy (average 19.5 Gy) should produce at least the same benefit as that given by the 4 × 9.5 Gy scheme, and it should reduce the expected total complication probability by

  2. 浅层地热能开发利用适宜性分区方法研究--以安徽省浅层地热能调查评价为例%MethoDoloGiCAl StuDy of SuitAbility ZoninG of ShAllow GeotherMAl DevelopMent AnD utiliZAtion-with ShAllow GeotherMAl enerGy inveStiGAtion AnD ASSeSSMent AS exAMple

    Institute of Scientific and Technical Information of China (English)

    官煜; 魏永霞; 陈学锋; 李志刚

    2014-01-01

    Based on study of the method of suitability zoning of shallow geothermal development and utilization in Anhui Province, this paper put forward a method combining key factor method, analytical hierarchy process and synthetic index, with shallow geothermal energy occurrence, technical, economic and environmental conditions as assessment factor, and key factor as necessary condition. This comprehensive assessment method can objectively reflect suitability features of development and utilization the assessment area. Suitability zoning is an important fundamental work that runs through the whole process of shallow geothermal energy investigation and assessment and guides reasonable development and utilization. The choice of zoning method and assessment factor should suit the local conditions.%通过对安徽省浅层地热能开发利用适宜性分区方法进行研究,提出以浅层地热能资源赋存及技术经济、环境条件为评价因子,以关键因子为必要条件,采用关键因子法、层次分析法及综合指数法进行适宜性分区的方法;该综合评价方法能客观反映评价区开发利用适宜性特征。适宜性分区是贯穿于浅层地热能调查评价工作全过程并指导合理开发利用的重要基础性工作,其分区方法及评价因子选取需要紧密结合实际、因地制宜。

  3. Kolga-Jaani kihelkond ja Vabaduse Risti vennad / Jaak Pihlak

    Index Scriptorium Estoniae

    Pihlak, Jaak

    2003-01-01

    Viljandimaaga seotud järgmiste Vabadusristi kavaleride elulood: Jakob Aaren, Joosep Aas, Anton Anni, Jakob Ant, Peeter-Viktor Kanasaar, Julius Kasper, Martin-Alexander Kepmann, Georg Kesküla, Peeter Kolts, Joosep Korts, August Kull, Georg Kütt, Georg Liiv, Eduard Meijel, August Moks, Theodor Mölter, Arnold-Rudolf Orik, August Paia, Aleksander Pajur, Oskar Parvet, Tõnis Pedak, August Pent, Heinrich Puidak, Jaan Päsna, Elmar Rei, Ernst Saar, Jüri Saks, August Schönberg, August-Johannes Teose, Hans Timpson, Anton Unt, Julian Vares, Paul Vares

  4. Old Romanian Meteorological Terms

    Directory of Open Access Journals (Sweden)

    Pelin Liviu-Ioan

    2016-10-01

    Full Text Available This paper aims to present the evolution of the meteorological terminology, from the 17th century Grigore Ureche’s chronicle and bishop Amfilohie Hotiniul's manuscript on Physics (Moldavia, late 18th Century to the mid 19th century writings of Teodor Stamati (Moldova and Julius Barasch (Wallachia, also considering pop science literature, newspapers, such as “Albina Românească” and weather superstitions published in various calendars, and disputed by intelectuals like Mihail Kogălniceanu.

  5. Bruno's Spaccio and Hyginus' Poetica Astronomica

    DEFF Research Database (Denmark)

    Catana, Leo

    2000-01-01

    The narrative framework of Giordano Bruno’s dialogue Lo spaccio de la bestia trionfante was inspired by Lucian of Samosata and his dialogue The Parliament of the Gods. In this article it is argued that Bruno, within that framework, developed an abundant imagery of astrological constellations...... inspired by the Poetica astronomica, a text ascribed to the Roman mythographer and astronomer Gaius Julius Hyginus (2nd century AD). Already in Lucian’s dialogue, astrological constellations were incorporated into the narrative framework, and precisely this union was imitated in the Renaissance by Leon...

  6. Government Procurement. Crimes and Offenses (Thesis I of a Two-Thesis Project)

    Science.gov (United States)

    1983-08-01

    moon SHAKESPEARE, JULIUS CAESAR, act IV, scene iii, lines 9-27 reprinted in I THE PLAYS AND SONNETS OF WILLIAM SHAKESPEARE 588 (W. Clarke & W. Wright...the remaining $400,000 per plane payment being still con- 73 • " ".’-’’-" "" + " . .. . • - + . • . "... . . ..*’,. .,...... .’... . *..-." ’ A...States v. Standefer, supra note 29, at 1080; United States v. Niederberger, supra note 20, at 68-69. 73 . United States v. Brewster, supra note 7, at 82. 74

  7. Propiedades materiales y experiencias subjetivas : los modelos anatómicos de Gustav Zeiller (1850-1904)

    OpenAIRE

    Fakiner, Nike Verena

    2014-01-01

    Los protagonistas de esta tesis doctoral son artefactos materiales, modelos anatómicos en cera, fabricados por Gustav Zeiller, un modelador anatómico, muy poco estudiado hasta la fecha. La investigación de modelos anatómicos ha llamado la atención a investigadores de excelencia como Nick Hopwood, Thomas Schnalke o Renato Manzollini que han analizado su papel en la práctica anatómica. También Julius von Schlosser, el discípulo de Aby Warburg, estudió artefactos en cera en diversas prácticas cu...

  8. Jaani kirik Peterburis = St. John's Church in St. Petersburg / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2011-01-01

    1860. a. Peterburis avatud Jaani kirikust (arhitekt Harald Julius von Bosse) ja neoromaani stiilis kirikuhoone taastamisest. Maja taastati väliselt oma ajaloolisel kujul, kuid interjöör loodi kaasaegseid vajadusi arvestades. Sisearhitekt Juta Lember, tema selgitused. Tellija: Eesti Kontsert. Projekteerijad: НИИ Спецпроектреставрация, E. J. Merkurjevi Arhitektuuribüroo. Eestis valmistati eritellimusel mööbel,saali valgustid, kirikuinventar. Projekt: 2005-2010, valmis: 2011

  9. [Private clinics in Nuremberg in the 19th and 20th century].

    Science.gov (United States)

    Vasold, Manfred

    2008-01-01

    As a consequence of the industrialization German cities grew very rapidly during the 19th century. Nuremberg reached the number of 100 000 in 1881. Although that city had a large Municipality Hospital (since 1845), a number of specialized private hospitals was founded. Julius Cnopf, a doctor from Nuremberg, founded a children's hospital, one of the first children's hospitals in Germany. The Nuremberg Muncipality Hospital had more than 1000 beds before 1914 and many more than 2000 after 1945, for this reason the number of private owned hospitals remained rather small. Nonetheless were these small and highly specialized hospitals quite important for the city population of Nuremberg.

  10. The history of time a very short introduction

    CERN Document Server

    Holford-Strevens, Leofranc

    2005-01-01

    Leofranc Holford-Strevens explores time measurement and the organisation of time into hours, days, months and years using a range of fascinating examples from Ancient Rome and Julius Caesar's Leap Year, to the 1920s' project for a fixed Easter. - ;Why do we measure time in the way that we do? Why is a week seven days long? At what point did minutes and seconds come into being? Why are some calendars lunar and some solar? The organisation of time into hours, days, months and years seems immutable and universal, but is actually far more artificial than most people realise. The French Revolution

  11. Venus - Crater Aurelia

    Science.gov (United States)

    1990-01-01

    This Magellan image shows a complex crater, 31.9 kilometers (20 miles) in diameter with a circular rim, terraced walls, and central peaks, located at 20.3 degrees north latitude and 331.8 degrees east longitude. Several unusual features are evidenced in this image: large dark surface up range from the crater; lobate flows emanating from crater ejecta, and very radar-bright ejecta and floor. Aurelia has been proposed to the International Astronomical Union, Subcommittee of Planetary Nomenclature as a candidate name. Aurelia is the mother of Julius Caesar.

  12. Bernd Herzogenrath (ed. From Virgin Land to Disney World : Nature and Its Discontents in the U.S.A. of Yesterday and Today. Critical Studies, Vol. 15.

    Directory of Open Access Journals (Sweden)

    Thomas Carmichael

    2006-04-01

    Full Text Available The essays in this volume present diverse readings of the place of nature in American culture from the European arrival to the postmodern period. Theoretically informed and richly considered, these essays can loosely be divided into those which take a specific historical moment or representation as their object—Thomas Cole’s Hudson river paintings, Poe’s Julius Rodman, antinomianism in the 1960s, Sam Peckinpah,’s The Wild Bunch, or the cultural logic of the Las Vegas strip, to cite just a few...

  13. Voice-Controlled Artificial Handspeak System

    Directory of Open Access Journals (Sweden)

    Carlo Fonda

    2014-01-01

    Full Text Available A man-machine interaction project is described which aims to establish an automated voice to sign language translator for communication with the deaf using integrated open technologies. The first prototype consists of a robotic hand designed with OpenSCAD and manufactured with a low-cost 3D printer ─which smoothly reproduces the alphabet of the sign language controlled by voice only. The core automation comprises an Arduino UNO controller used to activate a set of servo motors that follow instructions from a Raspberry Pi mini-computer having installed the open source speech recognition engine Julius. We discuss its features, limitations and possible future developments.

  14. Jaani kirik Peterburis = St. John's Church in St. Petersburg / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2011-01-01

    1860. a. Peterburis avatud Jaani kirikust (arhitekt Harald Julius von Bosse) ja neoromaani stiilis kirikuhoone taastamisest. Maja taastati väliselt oma ajaloolisel kujul, kuid interjöör loodi kaasaegseid vajadusi arvestades. Sisearhitekt Juta Lember, tema selgitused. Tellija: Eesti Kontsert. Projekteerijad: НИИ Спецпроектреставрация, E. J. Merkurjevi Arhitektuuribüroo. Eestis valmistati eritellimusel mööbel,saali valgustid, kirikuinventar. Projekt: 2005-2010, valmis: 2011

  15. Notions of Positivity and the Geometry of Polynomials

    CERN Document Server

    Branden, Petter; Putinar, Mihai

    2011-01-01

    The book consists of solicited articles from a select group of mathematicians and physicists working at the interface between positivity and the geometry, combinatorics or analysis of polynomials of one or several variables. It is dedicated to the memory of Julius Borcea (1968-2009), a distinguished mathematician, Professor at the University of Stockholm. With his extremely original contributions and broad vision, his impact on the topics of the planned volume cannot be underestimated. All contributors knew or have exchanged ideas with Dr. Borcea, and their articles reflect, at least partially

  16. [The physician and cosmetics--distorted images reflected in German medical historiography].

    Science.gov (United States)

    Sander, Sabine

    2003-01-01

    Physicians have been experts in cosmetics for thousands of years. Especially since the early modern period they have produced medical advice literature that included the topic of cosmetics for a general readership. Medical historians have paid scant attention to this aspect of doctors' activities, and when they did, this happened partly in a rather prejudiced manner, resulting in long-lasting misjudgements. This is illustrated with special reference to the case of the Berlin doctor and medical historian Julius Leopold Pagel (1851-1912).

  17. Suffodit inguina.

    Science.gov (United States)

    Betzig, Laura

    2014-01-01

    When Julius Caesar was stabbed, 23 times, on the Ides of March, at least one of the daggers is supposed to have gone into his groin. He wasn't the last Roman to have his privates attacked. And he wasn't the last primate. In competition for sexual access, gonads are occasionally targeted: canine incisions in monkey and ape scrota are not uncommon; and rumors had a number of Roman emperors--from Caligula and Nero, to Galba, Vitellius, Domitian, Commodus, Caracalla, Elagabalus, to Balbinus, Pupienus and Valerian over the course of the third century crisis--done in with their genitals at risk, or with their genitals cut off.

  18. Greek or Roman historical personages in the Quixote

    Directory of Open Access Journals (Sweden)

    Juan Antonio López Férez

    2008-12-01

    Full Text Available This paper concentrates on the presence of Greek or Roman historical personages in Don Quixote, offering the passages with the pertinent commentary and notes. Following a chronological order, and indicating in brackets the number of mentions, we have: Lycurgus (1; Tulia, Servius Tulius daughter (1; Lucretia (2; Horatius Cocles (1; Caius Mucius Scevola (1; Artemisia-Mausolus (1; Alexander the Great (13; Hannibal (2; Publius Cornelius Scipio, Africanus (1; Viriatus (1; Sulla-Marius-Catillina (1; Julius Caesar (6; Portia (1; Augustus (2; Nero (2; Traianus-Hadrianus (1.

  19. Quand le savant l’emporte sur le politique

    Directory of Open Access Journals (Sweden)

    David Diallo

    2009-07-01

    Full Text Available In this article, I examine some of the reactions that William Julius Wilson’s The Declining Significance of Race has triggered among his colleagues and among black activists. I explain that some criticisms, clearly at odds with scientific research, are the result of ideological interpretations that completely divorce Wilson’s work from its scholarly context. Through my analysis of the controversy caused by Wilson thesis, I importantly address issues of methodology, analytical rigor, and objectivity in scholarly works and emphasize highly biased assumptions presented by myopic researchers who let racial and political ideology take precedence over objectivity.

  20. [Images of epilepsy in Shakespeare].

    Science.gov (United States)

    Breuer, Horst

    2002-01-01

    Epilepsy and the "falling sickness" are mentioned three times in Shakespeare, in Julius Caesar, I.ii, Othello, IV.i., and figuratively in King Lear, II.ii. The present article surveys these passages in the context of modern research findings, literary as well as medico-historical. It adds further material from Renaissance texts and concludes that epilepsy is an omnibus term for a variety of symptoms and pathological conditions, and that Shakespeare's idea of epilepsy is closer to popular stereotypes than has hitherto been assumed.

  1. SU-E-P-52: Dose-Volume Toxicity Analysis of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Bergamo, A; Kauweloa, K; Daniels, J; Crownover, R; Mavroidis, P; Papanikolaou, N; Gutierrez, A [Cancer Therapy and Research Center, San Antonio, TX (United States)

    2015-06-15

    Purpose: To investigate the relationship between physical and biological effective dose (BED) to liver toxicity for SBRT fractionations. Methods: A total of 16 patients (13–10×3Gy, 2–5×10Gy and 1–3×15Gy were selected. Physical dose distributions were converted to voxel based BED values using the linear-quadratic (LQ) and linear-quadratic linear (LQ-L) models for doses per fraction larger than 6Gy. Patients were graded for effective toxicity (post-treatment minus pre-treatment grades) using the RTOG Late Radiation Morbidity Scoring Schema associated with Radiation Induced Liver Disease (RILD). Evaluated physical dose-volume levels consisted of V10Gy, V15Gy, V20Gy, V25Gy and V30Gy which were then converted to BED values corresponding to V16.7Gy3, V30Gy3, V46.7Gy3, V66.7Gy3 and V90Gy3, respectively. All levels were normalized to their respective patient normal liver volumes (NLV) and evaluated for correlation to RILD. Results were measured quantitatively using R-squared regression analysis. Results: Mean Dose Tolerable to Normal Liver (MDTNL) against RILD grade resulted in an R-squared value of 0.0104. NLV-normalized physical dose linear regression fit of V10Gy, V15Gy, V20Gy, V25Gy and V30Gy against RILD yielded R-squared values of 0.1041, 0.0895, 0.0698, 0.0398 and 0.0009 while BED levels of V16.7Gy3, V30Gy3, V46.7Gy3, V66.7Gy3 and V90Gy3 resulted in values of 0.0002, 0.0153, 0.0533, 0.0427 and 0.0072, respectively. The average NLV-normalized V10Gy, V15Gy, V20Gy, V25Gy and V30Gy per grade plotted against RILD grade yielded R-squared correlations of 0.8092, 0.6362, 0.5899, 0.5846 and 0.0224 while the BED levels of V16.7Gy3, V30Gy3, V46.7Gy3, V66.7Gy3 and V90Gy3 resulted in R-squared correlations of 0.0003, 0.3831, 0.8476, 0.678 and 0.076, respectively. Conclusion: Regression analysis between physical dose, BED and RILD showed strong correlation for the V30Gy and V46.7Gy3 dose-levels. Average BED and physical dose per grade both exhibit strong correlations to

  2. [Clinical treatment outcome of grade III, non-small cell bronchogenic carcinoma using "whole-body" gamma-knife system].

    Science.gov (United States)

    Uong, Iang-Zhie; Uong, Eong; Ksia, Ting-Ii; Kakhkhorov, Zh N; Razakov, A P

    2010-01-01

    The results of treatment of 80 patients with non-small cell lung cancer using the Chinese-made "Whole-Body" gamma-knife system were analyzed. Primary focus and involved lymph nodes were exposed. Neither gap between primary focus and involved lymph node or nodes, nor organs of the mediastinum were exposed. Exposure regimens were: STD = 4 Gy (2.5 - 10 Gy) 5 times a week; TTD=48 Gy (27-52 Gy) per primary focus and 4 Gy (3-6 Gy) 5 times a week; TTD = 43.5 Gy (30-52 Gy) per lymph nodes (105.6 - 150 Gy = equ.). Complete response was observed in 27.5% (22/80), partial - 42.5% (34/80). Overall survival was 61.3% among those sick for one year; 41.5%--2 years and 20.75%--3 years (mean survival time--20 months).

  3. Radiation-induced hypopituitarism is dose-dependent

    Energy Technology Data Exchange (ETDEWEB)

    Littley, M.D.; Shalet, S.M.; Beardwell, C.G.; Robinson, E.L.; Sutton, M.L. (Christie Hospital and Holt Radium Inst., Manchester (UK) Withington Hospital, Manchester (UK))

    1989-09-01

    Radiation-induced hypopituitarism has been studies prospectively for up to 12 years in 251 adult patients treated for pituitary disease with external radiotherapy, ranging in dose from 20 Gy in eight fractions over 11 days to 45 Gy in 15 fractions over 21 days. Ten further patients were studied 2-4 years after whole-body irradiation for haematological malignancies using 12 Gy in six fractions over 3 days and seven patients were studied 3-11 years after whole-brain radiotherapy for a primary brain tumour (30 Gy, eight fractions, 11 days). Five years after treatment, patients who received 20 Gy had an incidence of TSH deficiency of 9% and in patients treated with 35-37 Gy, 40 Gy and 42-45 Gy, the incidence of TSH deficiency increased significantly with increasing dose. A similar relationship was observed for both ACTH and gonadotrophin deficiencies when the 20 Gy group was compared to patients treated with 35-45 Gy. Growth hormone deficiency was universal by 5 years over the dose range 35-45 Gy. In seven patients who were treated with 30 Gy in eight fractions over 11 days, deficiencies were observed at a similar frequency to the 40 Gy group (15 fractions, 21 days). No evidence of pituitary dysfunction was detected in the ten patients who received 12 Gy (six fractions, 3 days). (author).

  4. Second Study of Hyper-Fractionated Radiotherapy

    Directory of Open Access Journals (Sweden)

    R. Jacob

    1999-01-01

    Full Text Available Purpose and Method. Hyper-fractionated radiotherapy for treatment of soft tissue sarcomas is designed to deliver a higher total dose of radiation without an increase in late normal tissue damage. In a previous study at the Royal Marsden Hospital, a total dose of 75 Gy using twice daily 1.25 Gy fractions resulted in a higher incidence of late damage than conventional radiotherapy using 2 Gy daily fractions treating to a total of 60 Gy. The current trial therefore used a lower dose per fraction of 1.2 Gy and lower total dose of 72 Gy, with 60 fractions given over a period of 6 weeks.

  5. Re-distribution of brachytherapy dose using a differential dose prescription adapted to risk of local failure in low-risk prostate cancer patients

    DEFF Research Database (Denmark)

    Rylander, Susanne; Polders, Daniel; Steggerda, Marcel J;

    2015-01-01

    . The median D10% and D30% to the urethra significantly decreased by 9Gy and 11Gy, respectively and for bladder neck by 18Gy and 15Gy, respectively. The median rectal D2.0cm(3) had a significant decrease of4Gy, while the median rectal D0.1cm(3) showed an increase of 1Gy. CONCLUSIONS: Our risk adaptive target......- and dose prescription concept of prescribing a lower dose to the whole gland and an escalated dose to the GTV using LDR-BT seed planning was technically feasible and resulted in a significant dose-reduction to urethra and bladder neck....

  6. Stereotactic radiosurgery for newly diagnosed brain metastases. Comparison of three dose levels

    Energy Technology Data Exchange (ETDEWEB)

    Rades, Dirk [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); Hornung, Dagmar [University Medical Center Hamburg-Eppendorf, Department of Radiation Oncology, Hamburg (Germany); Blanck, Oliver [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); CyberKnife Center Northern Germany, Guestrow (Germany); Martens, Kristina [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); University of Luebeck, Center for Integrative Psychiatry, Luebeck (Germany); Khoa, Mai Trong [Hanoi Medical University, Department of Nuclear Medicine, Hanoi (Viet Nam); Bach Mai Hospital, Nuclear Medicine and Oncology Center, Hanoi (Viet Nam); Trang, Ngo Thuy [Bach Mai Hospital, Nuclear Medicine and Oncology Center, Hanoi (Viet Nam); Hueppe, Michael [University of Luebeck, Department of Anesthesiology, Luebeck (Germany); Terheyden, Patrick [University of Luebeck, Department of Dermatology, Luebeck (Germany); Gliemroth, Jan [University of Luebeck, Department of Neurosurgery, Luebeck (Germany); Schild, Steven E. [Mayo Clinic Scottsdale, Department of Radiation Oncology, Scottsdale (United States)

    2014-09-15

    Three doses were compared for local control of irradiated metastases, freedom from new brain metastases, and survival in patients receiving stereotactic radiosurgery (SRS) alone for one to three newly diagnosed brain metastases. In all, 134 patients were assigned to three groups according to the SRS dose given to the margins of the lesions: 13-16 Gy (n = 33), 18 Gy (n = 18), and 20 Gy (n = 83). Additional potential prognostic factors were evaluated: age (≤ 60 vs. > 60 years), gender, Karnofsky Performance Scale score (70-80 vs. 90-100), tumor type (non-small-cell lung cancer vs. melanoma vs. others), number of brain metastases (1 vs. 2-3), lesion size (< 15 vs. ≥ 15 mm), extracranial metastases (no vs. yes), RPA class (1 vs. 2), and interval of cancer diagnosis to SRS (≤ 24 vs. > 24 months). For 13-16 Gy, 18 Gy, and 20 Gy, the 1-year local control rates were 31, 65, and 79 %, respectively (p < 0.001). The SRS dose maintained significance on multivariate analysis (risk ratio: 2.25; 95 % confidence interval: 1.56-3.29; p < 0.001). On intergroup comparisons of local control, 20 Gy was superior to 13-16 Gy (p < 0.001) but not to 18 Gy (p = 0.12); 18 Gy showed a strong trend toward better local control when compared with 13-16 Gy (p = 0.059). Freedom from new brain metastases (p = 0.57) and survival (p = 0.15) were not associated with SRS dose in the univariate analysis. SRS doses of 18 Gy and 20 Gy resulted in better local control than 13-16 Gy. However, 20 Gy and 18 Gy must be compared again in a larger cohort of patients. Freedom from new brain metastases and survival were not associated with SRS dose. (orig.) [German] Drei Dosislevel bei der alleinigen stereotaktischen Radiochirurgie (SRS) von 1 bis 3 neu diagnostizierten Hirnmetastasen wurden hinsichtlich lokaler Kontrolle der bestrahlten Metastasen, Nichtauftreten neuer Hirnmetastasen und Gesamtueberleben verglichen. Nach der am Rand der Metastasen applizierten SRS-Dosis wurden 134 Patienten den Gruppen 13

  7. My Continuing Evolution as a Surgeon-Scientist: A Decade after the Jacobson Promising Investigator Award.

    Science.gov (United States)

    Tzeng, Edith

    2017-01-01

    THE SECOND JOAN L AND JULIUS H JACOBSON PROMISING INVESTIGATOR AWARDEE, EDITH TZENG MD, FACS: In 2005, the Surgical Research Committee of the American College of Surgeons was tasked with selecting the recipient of a newly established award, "The Joan L and Julius H Jacobson Promising Investigator Award." According to the Jacobsons, the award funded by Dr Jacobson should be given at least once every 2 years to a surgeon investigator at "the tipping point," who can demonstrate that his or her research shows the promise of leading to a significant contribution to the practice of surgery and patient safety. Every year, the Surgical Research Committee receives many excellent nominations and has the difficult task of selecting one awardee. The first awardee was Michael Longaker MD, FACS, who 10 years later reflected on the award and the impact it had on his career.(1) This year, Edith Tzeng, MD, FACS, the second Jacobson awardee, reflects on her 10-year journey after receiving the award. Dr Tzeng is now a national and international figure in the field of vascular surgery and has studied the effect of nitric oxide and carbon monoxide on intimal hyperplasia. Kamal MF Itani, MD, FACS and Leigh Neumayer, MD, FACS, on behalf of the Surgical Research Committee of the American College of Surgeons.

  8. "I can't wait to find out what Nature has in store for us"

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Professor Guido Altarelli, a physicist at CERN and the University of Rome, has received two prizes since the beginning of the year: the Julius Wess prize awarded by the Karlsruhe Institute of Technology (KIT) and the Sakurai prize awarded by the American Physical Society.   Guido Altarelli (left), receiving the Julius Wess prize in Karlsruhe on 16 January. It's been a good start to the year for Guido Altarelli. After receiving two prestigious prizes in the space of a few weeks for achievements during his long career, all he's waiting for is the Higgs boson! "I can't wait to find out what Nature has in store for us!", he smiles. Hardly surprising when you think that Altarelli has been looking for the answers since the very start of his career in particle physics. As a theorist at CERN for over twenty years, he has always worked closely with the experiments, first at the SPS, then at LEP and now at the LHC. Today, following the significant progress in...

  9. Risk of dry eye syndrome in patients treated with whole-brain radiotherapy.

    Science.gov (United States)

    Nanda, Tavish; Wu, Cheng-Chia; Campbell, Ashley A; Bathras, Ryan M; Jani, Ashish; Kazim, Michael; Wang, Tony J C

    2017-08-04

    With improvements in systemic therapy, patients with cancer treated with whole-brain radiotherapy (WBRT) are living long enough to develop late toxicities, including dry eye syndrome. In general practice, dose to the lacrimal gland (LG) is not constrained (maximum constraint <40 Gy) in WBRT. The purpose of this study was to measure dose to the LG in WBRT and determine methods for reducing radiation exposure. We conducted a retrospective review of 70 3-dimensional (3D) conformal plans; thirty-six plans with a radiation prescription of 30 Gy in 10 fractions and 34 plans with a prescription of 37.5 Gy in 15 fractions. LGs were contoured in accordance with Freedman and Sidani (2015). Biological effective dose (BED)3 maximum constraints were calculated from 40 Gy and 20 Gy to be 32.17 Gy (30 Gy) and 36.70 Gy (37.5 Gy). Both regimens demonstrated supraorbital blocking by 3 methods: T1, bordering the supraorbital ridge; T2, no contact with supraorbital ridge; and T3, coverage of the supraorbital ridge. Mean dose for the plans with a 30-Gy prescription and the plans with a 37.5-Gy prescription was 27.5 Gy and 35.2 Gy, respectively (p ≤ 0.0001). BED3 maximum constraint (Dmax) was violated 16 of 26 (61.5%) in T1 (average Dmax: 32.2 Gy), 13 of 28 (46.4%) in T2 (average Dmax: 32.1 Gy), and 5 of 18 (27.8%) in T3 (average Dmax: 31.8 Gy) for the 30-Gy prescription. Dmax was violated in 32 of 32 (100%) in T1 (average Dmax: 40.1 Gy), 22 of 22 (100%) in T2 (average Dmax: 40.3 Gy), and 14 of 14 (100%) in T3 (average Dmax: 39.4) for the 37.5 Gy prescription. Average Dmax for the 37.5-Gy prescription was highly significant in favor of T3 (p = 0.0098). Patients who receive WBRT may develop dry eye syndrome as a late toxicity. Constraints are commonly violated with a prescription of 37.5 Gy. Methods to reduce dose include T3 supraorbital blocking, an easily implementable change that may dramatically improve patient quality of life. Copyright © 2017

  10. Adult exposures from MDCT including multiphase studies: first Italian nationwide survey

    Energy Technology Data Exchange (ETDEWEB)

    Palorini, Federica; Origgi, Daniela [Fisica Sanitaria Istituto Europeo di Oncologia, Milan (Italy); Granata, Claudio [UOC di Radiologia Istituto Giannina Gaslini, Genoa (Italy); Matranga, Domenica [Universita degli Studi di Palermo, Dipartimento di Scienze per la Promozione della Salute e Materno-infantile ' ' G. D' Alessandro' ' , Palermo (Italy); Salerno, Sergio [Policlinico Universita di Palermo, Dipartimento di Scienze Radiologiche, Palermo (Italy)

    2014-02-15

    To evaluate the radiation dose in routine multidetector computed tomography (MDCT) examinations in Italian population. This was a retrospective multicentre study included 5,668 patients from 65 radiology departments who had undergone common CT protocols: head, chest, abdomen, chest-abdomen-pelvis (CAP), spine and cardiac. Data included patient characteristics, CT parameters, volumetric CT dose index (CTDI{sub vol}) and dose length product (DLP) for each CT acquisition phase. Descriptive statistics were calculated, and a multi-regression analysis was used to outline the main factors affecting exposure. The 75th percentiles of CTDI{sub vol} (mGy) and DLP (mGy cm) for whole head were 69 mGy and 1,312 mGy cm, respectively; for chest, 15 mGy and 569 mGy cm; spine, 42 mGy and 888 mGy cm; cardiac, 7 mGy and 131 mGy cm for calcium score, and 61 mGy and 1,208 mGy cm for angiographic CT studies. High variability was present in the DLP of abdomen and CAP protocols, where multiphase examinations dominated (71 % and 73 % respectively): for abdomen, 18 mGy, with 555 and 920 mGy cm in abdomen and abdomen-pelvis acquisitions respectively; for CAP, 17 mGy, with 508, 850 and 1,200 mGy cm in abdomen, abdomen-pelvis and CAP acquisitions respectively. The results of this survey could help in the definition of updated diagnostic reference levels (DRL). (orig.)

  11. A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases

    OpenAIRE

    Rodrigues George; Yartsev Slav; Tay Keng; Pond Gregory R; Lagerwaard Frank; Bauman Glenn

    2012-01-01

    Abstract Background Our research group has previously published a dosimetric planning study that demonstrated that a 60 Gy/10 fractions intralesional boost with whole-brain radiotherapy (WBRT) to 30 Gy/10 fractions was biologically equivalent with a stereotactic radiosurgery (SRS) boost of 18 Gy/1 fraction with 30 Gy/10 fractions WBRT. Helical tomotherapy (HT) was found to be dosimetrically equivalent to SRS in terms of target coverage and superior to SRS in terms of normal tissue tolerance. ...

  12. Evaluation of the toxicity of the methanolic extract of Caesalpinia Pyramidalis, subjected to gamma radiation, compared to saline artemias; Avaliacao da toxicidade do extrato metanolico de Caesalpinia Pyramidalis, submetido a radiacao gama, frente a artemias salinas

    Energy Technology Data Exchange (ETDEWEB)

    Pessoa, Juanna G.; Santos, Mariana L.O.; Costa, Michelle C.A.; Siqueira, Williams N.; Silva, Luanna R.S.; Cabral, Daniela L.V.; Amancio, Francisco F.; Melo, Ana M.M.A., E-mail: marianasantos_ufpe@hotmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

    2013-07-01

    The present study aimed to investigate the possible effect of irradiation of 60 Co in methanol extract of Caesalpinia pyramidalis (catingueira) with function of reducing the toxicity of the extract at concentrations of 1000, 500, 250 and 125 ppm irradiating them with doses of 5 kGy 7 kGy and 10 kGy, using lethality tests with saline Artemias.

  13. Low-Dose Radiation Exposure and Atherosclerosis in ApoE(-/-) Mice

    NARCIS (Netherlands)

    Mitchel, R. E. J.; Hasu, M.; Bugden, M.; Wyatt, H.; Little, M. P.; Gola, A.; Hildebrandt, G.; Priest, N. D.; Whitman, S. C.

    2011-01-01

    The hypothesis that single low-dose exposures (0.025-0.5 Gy) to low-LET radiation given at either high (about 150 mGy/min) or low (1 mGy/min) dose rate would promote aortic atherosclerosis was tested in female C57BL/6J mice genetically predisposed to this disease (ApoE(-/-)). Mice were exposed eithe

  14. Identification of irradiated wheat using paramagnetic electronic resonance and germination test; Identificacao de trigo irradiado utilizando ressonancia paramagnetica eletronica e teste de germinacao

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Adilson C.; Arthur, Valter [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil); Freund, Maria Teresa L. [Sao Paulo Univ., SP (Brazil). Inst. de Fisica; Villavicenzio, Ana Lucia C.H. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    2000-07-01

    The objective of this research was to verify the possibility of detection of irradiated wheat by electron spin resonance spectroscopy, because ionizing radiation cause paramagnetic free radicals in materials and the germination test that established in radiobiological effects of inhibition of root-shoot lengths and germination percentages in seeds due radiation. For ESR spectroscopy, grains and shell have been irradiated with doses as follows: 0 kGy ; 1,0 kGy and 10,0 kGy at a dose rate of 6,20 kGy/h. For germination test only grains have been irradiated with 0 kGy; 0,10 kGy; 0,25 kGy; 0,50 kGy; 0,75 kGy; 1,0 kGy and 2,0 kGy at a dose rate of 1,724 kGy/h and stored by 90 days before germination. The ESR signal decay fast with time but shell have free radicals ten times more than grains by mass unit. As we can observe in germination test, occurs a reduction in development of root-shoot and germination percentages with dose increase. The results indicated that the ESR and germination test may be used for detection of irradiated wheat. (author)

  15. Hypofractionation vs Conventional Radiation Therapy for Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Matched-Cohort Analysis

    NARCIS (Netherlands)

    Janssens, G.O.R.J.; Jansen, M.H.; Lauwers, S.J.; Nowak, P.J.; Oldenburger, F.R.; Bouffet, E.; Saran, F.; Kamphuis-van Ulzen, K.; Lindert, E.J. van; Schieving, J.H.; Boterberg, T.; Kaspers, G.J.L.; Span, P.N.; Kaanders, J.H.A.M.; Gidding, C.E.M.; Hargrave, D.

    2013-01-01

    PURPOSE: Despite conventional radiation therapy, 54 Gy in single doses of 1.8 Gy (54/1.8 Gy) over 6 weeks, most children with diffuse intrinsic pontine glioma (DIPG) will die within 1 year after diagnosis. To reduce patient burden, we investigated the role of hypofractionation radiation therapy give

  16. Nutritional and chemical alteration of raw, irradiated and cooked chickpea (Cicer arietinum L.)

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Andrea C. Penati; Arthur, Valter [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)]. E-mails: andrea@dtr.com.br; acpferre@cena.usp.br; arthur@cena.usp.br; Brazzaca, Solange Guidolin Canniatti [Escola Superior de Agricultura Luis de Queiroz (ESALQ/USP), Piracicaba, SP (Brazil)]. E-mail: sgcbraza@esalq.usp.br

    2007-07-01

    The work objective was analyzing the centesimal and mineral composition to verifying the alterations on the nutritional characteristics caused by the cooking process. Also were carried out analysis of the iron availability in vitro, protein digestibility in vitro and the profile of amino acids in the raw and cooked in the control and irradiated seeds (doses of 2 kGy, 4 kGy, 6 kGy, 8 kGy and 10 kGy). The results of the mineral analysis showed that only phosphorus decrease with cooking process and it decreased ash and carbohydrates available. In the control and in the doses of 4 kGy and 6 kGy the cooking has not influenced the digestibility of the protein, but the treatments that received radiation doses of 2 kGy, 8 kGy and 10 kGy were influenced. The cooked chickpea has shown better digestibility in higher doses of radiation although the treatments have shown low digestibility. The raw chickpea presented a better dialysis of iron in the control and in the doses 2 kGy and 4 kGy and the cooked chickpea presented improvement according to the increase of radiation doses. In relation to the essential amino acids, the chickpea has presented an adequate nutritional value, except for the methionine. (author)

  17. Enhanced survival from radiation pneumonitis by combined irradiation to the skin.

    Science.gov (United States)

    Gao, Feng; Fish, Brian L; Szabo, Aniko; Schock, Ashley; Narayanan, Jayashree; Jacobs, Elizabeth R; Moulder, John E; Lazarova, Zelmira; Medhora, Meetha

    2014-09-01

    To develop mitigators for combined irradiation to the lung and skin. Rats were treated with X-rays as follows: (1) 12.5 or 13 Gy whole thorax irradiation (WTI); (2) 30 Gy soft X-rays to 10% area of the skin only; (3) 12.5 or 13 Gy WTI + 30 Gy skin irradiation after 3 hours; (4) 12.5 Gy WTI + skin irradiation and treated with captopril (160 mg/m(2)/day) started after 7 days. Our end points were survival (primary) based on IACUC euthanization criteria and secondary measurements of breathing intervals and skin injury. Lung collagen at 210 days was measured in rats surviving 13 Gy WTI. After 12.5 Gy WTI with or without skin irradiation, one rat (12.5 Gy WTI) was euthanized. Survival was less than 10% in rats receiving 13 Gy WTI, but was enhanced when combined with skin irradiation (p WTI vs. 13 Gy WTI + 30 Gy skin irradiation (p WTI + 30 Gy skin irradiation (p = 0.008). Radiation to the skin given 3 h after WTI mitigated morbidity during pneumonitis in rats. Captopril enhanced the rate of healing of radiation-dermatitis after combined irradiations to the thorax and skin.

  18. Treatment outcome and prognostic variables for local control and survival in patients receiving radical radiotherapy for urinary bladder cancer

    DEFF Research Database (Denmark)

    Fokdal, Lars; Høyer, Morten; Maase, Hans von der

    2004-01-01

    patients were treated by use of a standard 3-field technique with 60 Gy in 30 fractions to the tumor and the bladder. The elective lymph nodes were treated with doses in the range from 46 Gy to 60 Gy. Complete response was obtained in 52% of the patients at 3-month control. However, 41% of all patients...

  19. Adaptive response and split-dose effect of radiation on the survival of mice

    Indian Academy of Sciences (India)

    Ashu Bhan Tiku; R K Kale

    2004-03-01

    Although the importance of radiation-induced adaptive response has been recognized in human health, risk assessment and clinical application, the phenomenon has not been understood well in terms of survival of animals. To examine this aspect Swiss albino mice were irradiated with different doses (2–10 Gy) at 0.015 Gy/s dose rate and observed on a regular basis for 30 days. Since almost 50% lethality was seen with 8 Gy, it was selected as the challenging dose for further studies. Irradiation of mice with conditioning doses (0.25 or 0.5 Gy) and subsequent exposure to 8 Gy caused significant increase in the survival of mice compared to irradiated control. The splitting of challenging dose did not influence the efficiency of conditioning doses (0.25 Gy and 0.5 Gy) to induce an adaptive response. However conditioning doses given in fractions (0.25 Gy + 0.25 Gy) or (0.5 Gy + 0.5 Gy) were able to modulate the response of challenging dose of 8 Gy. These results clearly showed the occurrence of adaptive response in terms of survival of animals. The conditioning dose given in small fractions seemed to be more effective. The findings have been discussed from a mechanistic point of view. The possible biological implications, potential medical benefits, uncertainties and controversies related to adaptive response have also been addressed.

  20. Low-Dose Radiation Exposure and Atherosclerosis in ApoE(-/-) Mice

    NARCIS (Netherlands)

    Mitchel, R. E. J.; Hasu, M.; Bugden, M.; Wyatt, H.; Little, M. P.; Gola, A.; Hildebrandt, G.; Priest, N. D.; Whitman, S. C.

    The hypothesis that single low-dose exposures (0.025-0.5 Gy) to low-LET radiation given at either high (about 150 mGy/min) or low (1 mGy/min) dose rate would promote aortic atherosclerosis was tested in female C57BL/6J mice genetically predisposed to this disease (ApoE(-/-)). Mice were exposed

  1. Distribution of Absorbed Doses to the Important Organs of Head and Neck Region in Panoramic Radiography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byeong Sam; Choi, Karp Sick [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Deagu (Korea, Republic of); Kim, Chin Soo [Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Kyungpook National University, Deagu (Korea, Republic of)

    1990-08-15

    The purpose of this study was to estimate the distribution of absorbed doses of each important organs of head and neck region in panoramic radiography. Radiation dosimetry at internal anatomic sites and skin surfaces of phantom (RT-210 Humanoid Head and Neck Section R) was performed with lithium fluoride (TLD-100R) thermoluminescent dosimeters according to change of kilovoltage (65 kVp, 75 kVp and 85 kVp) with 4 miliamperage and 20 second exposure time. The results obtained were as follows; Radiation absorbed doses of internal anatomic sites were presented the highest does of 1.04 mGy, 1.065 mGy and 2.09 mGy in nasopharynx, relatively high doses of 0.525 mGy, 0.59 mGy and 1.108 mGy in deep lobe of parotid gland, 0.481 mGy, 0.68 mGy and 1.191 mGy in submandibular gland. But there were comparatively low doses of 0.172 mGy and 0.128 mGy in eyes and thyroid gland that absorbed dose was estimated at 85kVp. Radiation absorbed doses of skin surfaces were presented the highest doses of 1.263 mGy, 1.538 mGy and 2.952 mGy in back side of first cervical vertebra and relatively high doses of 0.267 mGy, 0.401 mGy and 0.481 mGy in parotid gland. But there were comparatively low doses of 0.057 mGy, 0.068 mGy and 0.081 mGy in philtrum and 0.059 mGy in middle portion of chin that absorbed dose was estimated at 85 kVp. According to increase of kilovoltage, the radiation absorbed doses were increased 1.1 times when kilovoltage changes from 65 kVp to 75 kVp and 1.9 times when kilovoltage changes from 75 kVp to 85 kVp at internal anatomic sites. According to increase of kilovoltage, the radiation absorbed doses were increased 1.3 times when kilovoltage changes from 65 kVp to 75 kVp and 1.6 times when kilovoltage changes from 75 kVp to 85 kVp at skin surfaces.

  2. Identification of QTLs for root characteristics in maize grown in hydroponics and analysis of their overlap with QTLs for grain yield in the field at two water regimes.

    Science.gov (United States)

    Tuberosa, Roberto; Sanguineti, Maria Corinna; Landi, Pierangelo; Giuliani, Marcella Michela; Salvi, Silvio; Conti, Sergio

    2002-01-01

    We investigated the overlap among quantitative trait loci (QTLs) in maize for seminal root traits measured in hydroponics with QTLs for grain yield under well-watered (GY-WW) and water-stressed (GY-WS) field conditions as well as for a drought tolerance index (DTI) computed as GY-WS/GY-WW. In hydroponics, 11, 7, 9, and 10 QTLs were identified for primary root length (R1L), primary root diameter (R1D), primary root weight (R1W), and for the weight of the adventitious seminal roots (R2W), respectively. In the field, 7, 8, and 9 QTLs were identified for GY-WW, GY-WS, and DTI, respectively. Despite the weak correlation of root traits in hydroponics with GY-WW, GY-WS, and DTI, a noticeable overlap between the corresponding QTLs was observed. QTLs for R2W most frequently and consistently overlapped with QTLs for GY-WW, GY-WS, and/or DTI. At four QTL regions, an increase in R2W was positively associated with GY-WW, GY-WS, and/or DTI. A 10 cM interval on chromosome 1 between PGAMCTA205 and php20644 showed the strongest effect on R1L, R1D, R2W, GY-WW, GY-WS, and DTI. These results indicate the feasibility of using hydroponics in maize to identify QTL regions controlling root traits at an early growth stage and also influencing GY in the field. A comparative analysis of the QTL regions herein identified with those described in previous studies investigating root traits in different maize populations revealed a number of QTLs in common.

  3. Availability of iron in grains common beans (Phaseolus vulgaris l.) irradiated;Disponibilidade de ferro em graos de feijao comum (Phaseolus vulgaris L.) irradiados

    Energy Technology Data Exchange (ETDEWEB)

    Brigide, Priscila

    2002-07-01

    Common bean is the legume more consuming in Brazil, however, the average income of the farming in Brazil is low must the infestation of the grains, to fight these losses the irradiation process is an alternative healthful if compared the chemical handling. The objective of this research was evaluate the iron availability in irradiated raw and cooked beans (doses of 0, 2, 6 and 10 kGy). It was carried through the centesimal composition, anti nutritional factors (tannins and phytate) and iron dialyses for the method 'in vitro'. Cooking diminished the mainly components of the composition with exception of available carbohydrates, the protein content of 27.4 and 23.9; fat 1.2 and 1.1; fibre 23.7 and 18.6, carbohydrates 43.3 and 52.5; respectively for raw grains and cooked. It also had reduction in the amount of tannin which if correlated reversely with the applied doses, with exception of the dose of 2 kGy, varying of 1.56 (10 kGy) to 2.49 (2 kGy) to the for raw grains and traces (10 kGy) to 0.103 (2 kGy ) for grains cooked. The phytate varied of 4.63 (2 kGy) to 8.28 (0 kGy) and 5.29 (6 kGy) to the 9.55 (0 kGy), respectively for raw grains and cooked. In relation to the dialysed iron, the content varied of 1.16 (0 kGy) to 2.39 (6 kGy) and 5.33 (0 kGy) to the 8.02 (6 kGy), respectively for raw grains and cooked The dose of 6 kGy showed positive effect availability such as raw as cooked grain, it being recommended for the utilization. (author)

  4. Effect of gamma radiation on growth, productivity and protein content of Chlorella Pyrenoidosa; Efecto de la radiacion gamma sobre el crecimiento, productividad y contenido proteico de Chlorella Pyrenoidosa

    Energy Technology Data Exchange (ETDEWEB)

    Martin, C.; Fernandez, J.

    1983-07-01

    The effect of five doses of gamma radiation: 10, 100, 500, 1000 and 5000 Gy at a dose rate of 4.500 Gy/h on growth, productivity and protein content of Chlorella pyroneidosa has been studied. High doses of gamma radiation have been observed to inhibit cellular division of Chlorella pyrenoidosa. Culture growth stopped 48 hours after irradiation at 5.000 Gy and 72 hours after irradiation at 500 and 1000 Gy. The lowest dose (10 Gy) produced a little growth stimulation that not statistically significative. Protein and aminoacid content did not show any change for gamma radiation doses studied. (Author) 32 refs.

  5. Gamma radiation tolerance in different life stages of the fruit fly Drosophila melanogaster.

    Science.gov (United States)

    Paithankar, Jagdish Gopal; Deeksha, K; Patil, Rajashekhar K

    2017-04-01

    Insects are known to have higher levels of radiation tolerance than mammals. The fruit fly Drosophila provides opportunities for genetic analysis of radiation tolerance in insects. A knowledge of stage-specific sensitivity is required to understand the mechanisms and test the existing hypothesis of insect radiation tolerance. Drosophila melanogaster were irradiated using gamma rays at different life stages. Irradiation doses were chosen to start from 100-2200 Gy with increments of 100 Gy, with a dose rate of 12.5 and 25 Gy/min. The threshold of mortality, LD50 and LD100 1 h post-irradiation was recorded for larvae and adults and 24 h post-irradiation for eggs and after 2-3 days for early and late pupae. Total antioxidant capacity for all the life stages was measured using the phosphomolybdenum method. Twenty-four hours post-irradiation, 100% mortality was recorded for eggs at 1000 Gy. One hour post irradiation 100% mortality was recorded at 1300 Gy for first instar larvae, 1700 Gy for second instar larvae, 1900 Gy for feeding third instar larvae and 2200 Gy for non-feeding third instar larvae. Post-irradiation complete failure of emergence (100% mortality) was observed at 130 Gy for early pupae and 1500 Gy for late pupae; 100% mortality was observed at 1500 Gy for adults. The values of LD50 were recorded as 452 Gy for eggs, 1049 Gy for first instar larvae, 1350 Gy for second instar larvae, 1265 Gy for feeding third instar larvae, 1590 Gy for non-feeding third instar larvae, 50 Gy for early pupae, 969 Gy for late pupae, 1228 Gy for adult males and 1250 Gy for adult females. Early pupae were found to be prone to radiation, whereas the non-feeding third instar larvae were most resistant among all stages. The chromosome number being constant and total antioxidant capacity being nearly constant in all stages, we suggest that high rate of cell division during early pupae makes this stage sensitive to radiation.

  6. Irradiation of Ceratitis capitata, Anastrepha fraterculus and Anastrepha obliqua larvae (Diptera: Tephritidae) on an artificial diet; Irradiacao de larvas de Ceratitis capitata, Anastrepha fraterculus e Anastrepha obliqua (Diptera: Tephritidae) em dieta artificial

    Energy Technology Data Exchange (ETDEWEB)

    Raga, A.; Sato, M.E.; Suplicy Filho, N.; Potenza, M.R. [Instituto Biologico, Sao Paulo, SP (Brazil); Yamazaki, M.C.R. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1992-01-01

    The aim of the experiment was to establish gamma radiation dose levels sufficient to prevent the emergence of adults, and thus to serve as parameters for disinfestation of hosts of the fruit-flies Ceratitis capitata, Anastrepha fraterculus, and Anastrepha obliqua. Four-, 5,6-, and 7-day-old larvae of the 3 species were tested. Pupation was unaffected by 40 Gy for C. capitata, and by 100 Gy for A. fraterculus and A. obliqua. Gamma radiation doses necessary to prevent development of adults from larvae were 30 Gy, 20 Gy and 20 Gy for C. capitata, A. obliqua respectively. (author). 10 refs, 6 tabs.

  7. JPRS Report - Science & Technology USSR: Life Sciences.

    Science.gov (United States)

    1988-08-04

    Obstruction 67. Cholelithiasis and Cholecystitis 68. Cirrhosis and Other Diseases of the Liver and the Bile Ducts 69. Other Diseases of the Digestive...with dose power at 0.0003 Gy/day was 2.6 times higher than that at 0.007 Gy/day. Relative frequency of mutations in P. sylvestris at 0.01 Gy per locus...at dose power of 0.00002 Gy/day was 2.7 times higher than that at 0.000015 Gy/day. The different relative yield of mutations under the effect of

  8. Retrospective Estimation of the Quality of Intensity-Modulated Radiotherapy Plans for Lung Cancer

    CERN Document Server

    Koo, Jihye; Chung, Weon Kuu; Kim, Dong Wook

    2015-01-01

    This study estimated the planning quality of intensity-modulated radiotherapy in 42 lung cancer cases to provide preliminary data for the development of a planning quality assurance algorithm. Organs in or near the thoracic cavity (ipsilateral lung, contralateral lung, heart, liver, esophagus, spinal cord, and bronchus) were selected as organs at risk (OARs). Radiotherapy plans were compared using the conformity index (CI), coverage index (CVI), and homogeneity index (HI) of the planning target volume (PTV), OAR-PTV distance and OAR-PTV overlap volume, and the V10Gy, V20Gy, and equivalent uniform dose (EUD) of the OARs. The CI, CVI, and HI of the PTV were 0.54 - 0.89 , 0.90 - 1.00 , and 0.11 - 0.41, respectively. The mean EUDs (V10Gy, V20Gy) of the ipsilateral lung, contralateral lung, esophagus, cord, liver, heart, and bronchus were 8.07 Gy (28.06, 13.17), 2.59 Gy (6.53, 1.18), 7.02 Gy (26.17, 12.32), 3.56 Gy (13.56, 4.48), 0.72 Gy (2.15, 0.91), 5.14 Gy (19.68, 8.62), and 10.56 Gy (36.08, 19.79), respectivel...

  9. The effects of gamma-ray irradiation to strawberry (Fragaria x ananassa Duch.) calli on shoot regeneration, achene formation and morphological variations of regenerants

    Energy Technology Data Exchange (ETDEWEB)

    Kasumi, Masakazu [Plant Biotechnology Inst., Ibaraki Agricultural Center, Iwama, Ibaraki (Japan)

    2002-05-01

    Strawberry (Fragaria x ananassa 'Nyoho') calli, derived from anthers, were irradiated with gamma -ray at dosages from 100 to 1,600 Gy (10 Gy {center_dot} hr{sup -}1) and their effects on callus growth, plant regeneration, and somaclonal variation were analyzed. The growth of callus and percentage of plant regeneration from the callus were reduced slightly at dosages less than 200 Gy, moderately at 400 Gy, and markedly above 800 Gy. Fruit growth associated with seed fertility (>50 % ) was morphologically normal at less than 100 Gy, whereas achene formation was significantly inhibited above 200 Gy. The percentages of morphological variation in regenerants formed from the irradiated callus were:13.7 (no irradiation), 18.6 (100 Gy), 66.0 (200 Gy), 75.7 (400 Gy), and 97.0 (800 Gy). Furthermore, higher dosages yielded wider variations, e.g., thick and small leaf, light leaf color, white flesh, and long fruit. In some regenerants, more than one morphological aberrations developed, some of which were transmissible to daughter plants. These results revealed that the irradiating strawberry callus with gamma - ray resulted in a higher degree and wider spectrum of somaclonal variation than did simple callus culture. (author)

  10. Effects of low dose gamma-ray radiation on the seed germination and physiological activity of vegetable crops

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Baek, M. H.; Lee, Y. G. [KAERI, Taejon (Korea, Republic of); Jung, K. H. [Kyunghee Univ., Yongin (Korea, Republic of)

    2000-10-01

    To determine the effect of low dose gamma-ray radiation on the germination rate and physiology of germinative seeds of Chinese cabbage(Brassica campestris L. cv. Hanyoreum) and radish(Raphanus sativus L. cv. Chungsukoungzoung). The germination rate of irradiation group was higher than that of the control. Especially it was highest at the early stage of induction. The germination rate of Chinese cabbage increased at 4 Gy-, 10 Gy- and 50 Gy irradiation group and that of radish increased at 2 Gy-, 6 Gy- and 10 Gy irradiation group. The seedling height of Chinese cabbage and radish increased positively in low dose irradiation group. The seedling height of Chinese cabbage was noticeably higher at 4 Gy and 10 Gy irradiation group and that of radish at 6 Gy irradiation group. The protein contents of seeds irradiated with low dose gamma-ray radiation was increased compared to that of the control especially at the early stage of induction. The enzyme activity of seeds irradiated with low dose of gamma-ray radiation was increased at 4 Gy and 10 Gy irradiation group. These results suggest that the germination and physiological activity of old seeds could be stimulated promisingly by the low dose gamma-ray radiation.

  11. Development of a Modelling to Correlate Site and Diameter of Brain Metastases with Hippocampal Sparing Using Volumetric Modulated Arc Therapy

    Directory of Open Access Journals (Sweden)

    Silvia Chiesa

    2013-01-01

    Full Text Available Purpose. To correlate site and diameter of brain metastases with hippocampal sparing in patients treated by RapidArc (RA technique on whole brain with simultaneously integrated boost (SIB. Methods and Materials. An RA plan was calculated for brain metastases of 1-2-3 cm of diameter. The whole brain dose was 32.25 Gy (15 fractions, and SIB doses to brain metastases were 63 Gy (2 and 3 cm or 70.8 Gy (1 cm. Plans were optimized and evaluated for conformity, target coverage, prescription isodose to target volume, homogeneity index, and hippocampal sparing. Results. Fifteen brain lesions and RA plan were generated. Hippocampal volume was 4.09 cm3, and hippocampal avoidance volume was 17.50 cm3. Related to site of metastases, the mean hippocampal dose was 9.68 Gy2 for occipital lobe, 10.56 Gy2 for frontal lobe, 10.56 Gy2 for parietal lobe, 10.94 Gy2 for deep brain structures, and 40.44 Gy2 for temporal lobe. The mean hippocampal dose was 9.45 Gy2, 10.15 Gy2, and 11.70 Gy2 for diameter’s metastases of 1.2 and 3 cm, respectively, excluding results relative to temporal brain lesions. Conclusions. Location more than size of metastases can adversely influence the hippocampus sparing. Further investigation is necessary to meet definitive considerations.

  12. Effects of low dose gamma radiation on the early growth of red pepper and the resistance to subsquent high dose of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Baek, M. H.; Kim, D. H.; Lee, Y. K. [KAERI, Taejon (Korea, Republic of); Lee, Y. B. [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-05-01

    Red pepper (capsicum annuum L. cv. Jokwang and cv. Johong) seeds were irradiated with the dose of 0{approx}50 Gy to investigated the effect of the low dose gamma radiation on the early growth and resistance to subsequent high dose of radiation. The effect of the low dose gamma radiation on the early growth and resistance to subsequenct high dose of radiation were enhanced in Johong cultivar but not in Jokwang cultivar. Germination rate and early growth of Johong cultivar were noticeably increased at 4 Gy-, 8 Gy- and 20 Gy irradiation group. Resistance to subsequent high dose of radiation of Johong cultivar were increased at almost all of the low dose irradiation group. Especially it was highest at 4 Gy irradiation group. The carotenoid contents and enzyme activity on the resistance to subsequent high dose of radiation of Johong cultivar were increased at the 4 Gy and 8 Gy irradiation group.

  13. Evaluation of {gamma}-radiation on green tea odor volatiles

    Energy Technology Data Exchange (ETDEWEB)

    Fanaro, G.B., E-mail: gbfanaro@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN)-Centro de Tecnologia das Radiacoes, Av. Professor Lineu Prestes, 2242, 05508-000 Sao Paulo, SP (Brazil); Duarte, R.C., E-mail: renatocduarte@yahoo.com.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN)-Centro de Tecnologia das Radiacoes, Av. Professor Lineu Prestes, 2242, 05508-000 Sao Paulo, SP (Brazil); Araujo, M.M., E-mail: mmozeika@yahoo.co [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN)-Centro de Tecnologia das Radiacoes, Av. Professor Lineu Prestes, 2242, 05508-000 Sao Paulo, SP (Brazil); Purgatto, E., E-mail: epurgatt@usp.b [Universidade de Sao Paulo-Faculdade de Ciencias Farmaceuticas, FCF/USP, Departamento de Alimentos e Nutricao Experimental, Av. Prof. Lineu Prestes, 580 Bloco 14, 05508-900, Sao Paulo, SP (Brazil); Villavicencio, A.L.C.H., E-mail: villavic@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN)-Centro de Tecnologia das Radiacoes, Av. Professor Lineu Prestes, 2242, 05508-000 Sao Paulo, SP (Brazil)

    2011-01-15

    The aim of this study was to evaluate the gamma radiation effects on green tea odor volatiles in green tea at doses of 0, 5, 10, 15 and 20 kGy. The volatile organic compounds were extracted by hydrodistillation and analyzed by GC/MS. The green tea had a large influence on radiation effects, increasing the identified volatiles in relation to control samples. The dose of 10 kGy was responsible to form the majority of new odor compounds following by 5 and 20 kGy. However, the dose of 5 kGy was the dose that degraded the majority of volatiles in non-irradiated samples, following by 20 kGy. The dose of 15 kGy showed has no effect on odor volatiles. The gamma radiation, at dose up to 20 kGy, showed statistically no difference between irradiated and non irradiated green tea on odors compounds.

  14. Evaluation of γ-radiation on green tea odor volatiles

    Science.gov (United States)

    Fanaro, G. B.; Duarte, R. C.; Araújo, M. M.; Purgatto, E.; Villavicencio, A. L. C. H.

    2011-01-01

    The aim of this study was to evaluate the gamma radiation effects on green tea odor volatiles in green tea at doses of 0, 5, 10, 15 and 20 kGy. The volatile organic compounds were extracted by hydrodistillation and analyzed by GC/MS. The green tea had a large influence on radiation effects, increasing the identified volatiles in relation to control samples. The dose of 10 kGy was responsible to form the majority of new odor compounds following by 5 and 20 kGy. However, the dose of 5 kGy was the dose that degraded the majority of volatiles in non-irradiated samples, following by 20 kGy. The dose of 15 kGy showed has no effect on odor volatiles. The gamma radiation, at dose up to 20 kGy, showed statistically no difference between irradiated and non irradiated green tea on odors compounds.

  15. Radioadaptive response for protection against radiation-induced teratogenesis.

    Science.gov (United States)

    Okazaki, Ryuji; Ootsuyama, Akira; Norimura, Toshiyuki

    2005-03-01

    To clarify the characteristics of the radioadaptive response in mice, we compared the incidence of radiation-induced malformations in ICR mice. Pregnant ICR mice were exposed to a priming dose of 2 cGy (667 muGy/min) on day 9.5 of gestation and to a challenging dose of 2 Gy (1.04 Gy/min) 4 h later and were killed on day 18.5 of gestation. The incidence of malformations and prenatal death and fetal body weights were studied. The incidence of external malformations was significantly lower (by approximately 10%) in the primed (2 cGy + 2 Gy) mice compared to the unprimed (2 Gy alone) mice. However, there were no differences in the incidence of prenatal death or the skeletal malformations or the body weights between primed and unprimed mice. These results suggest that primary conditioning with low doses of radiation suppresses radiation-induced teratogenesis.

  16. Three-dimensional dose accumulation in pseudo-split-field IMRT and brachytherapy for locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Sun, Baozhou; Yang, Deshan; Esthappan, Jackie

    2015-01-01

    intensity-modulated radiation therapy (IMRT) and image-guided BT in locally advanced cervical cancer. METHODS AND MATERIALS: Thirty-three patients treated with split-field-IMRT to 45.0-51.2 Gy in 1.6-1.8 Gy per fraction to the elective pelvic lymph nodes and to 20 Gy to the central pelvis region were......PURPOSE: Dose accumulation of split-field external beam radiotherapy (EBRT) and brachytherapy (BT) is challenging because of significant EBRT and BT dose gradients in the central pelvic region. We developed a method to determine biologically effective dose parameters for combined split-field...... to be -1 ± 4 Gy, -3 ± 5 Gy, 2 ± 3 Gy, and -3 ± 5 Gy for bladder, rectum, sigmoid, and GTV, respectively. CONCLUSIONS: It is feasible to perform 3D EQD2 dose accumulation to assess high and intermediate dose regions for combined split-field IMRT and BT....

  17. Medical reference dosimetry using EPR measurements of alanine

    DEFF Research Database (Denmark)

    Helt-Hansen, Jakob; Rosendal, F.; Kofoed, I.M.

    2009-01-01

    Background. Electron spin resonance (EPR) is used to determine the absorbed dose of alanine dosimeters exposed to clinical photon beams in a solid-water phantom. Alanine is potentially suitable for medical reference dosimetry, because of its near water equivalence over a wide energy spectrum, low...... on scaling of known spectra was developed to extract the alanine signal. Results. The dose accuracy, including calibration uncertainty, is less than 2% (k=1) above 4 Gy (n=4). The measurement uncertainty is fairly constant in absolute terms (30 mGy) and the relative uncertainty therefore rises for dose...... measurements below 4 Gy. Typical reproducibility is 1% (k=1) above 10 Gy and 2% between 4 and 10 Gy. Below 4 Gy the uncertainty is higher. A depth dose curve measurement was performed in a solid-water phantom irradiated to a dose of 20 Gy at the maximum dose point (dmax) in 6 and 18 MV photon beams...

  18. SU-E-T-315: The Change of Optically Stimulated Luminescent Dosimeters (OSLDs) Sensitivity by Accumulated Dose and High Dose

    Energy Technology Data Exchange (ETDEWEB)

    Han, S; Jung, H; Kim, M; Ji, Y; Kim, K [University of Science and Technology, Daejeon (Korea, Republic of); Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Choi, S; Park, S; Yoo, H [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Yi, C [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2014-06-01

    Purpose: The objective of this study is to evaluate radiation sensitivity of optical stimulated luminance dosimeters (OSLDs) by accumulated dose and high dose. Methods: This study was carried out in Co-60 unit (Theratron 780, AECL, and Canada) and used InLight MicroStar reader (Landauer, Inc., Glenwood, IL) for reading. We annealed for 30 min using optical annealing system which contained fluorescent lamps (Osram lumilux, 24 W, 280 ∼780 nm). To evaluate change of OSLDs sensitivity by repeated irradiation, the dosimeters were repeatedly irradiated with 1 Gy. And whenever a repeated irradiation, we evaluated OSLDs sensitivity. To evaluate OSLDs sensitivity after accumulated dose with 5 Gy, We irradiated dose accumulatively (from 1 Gy to 5 Gy) without annealing. And OSLDs was also irradiated with 15, 20, 30 Gy to certify change of OSLDs sensitivity after high dose irradiation. After annealing them, they were irradiated with 1Gy, repeatedly. Results: The OSLDs sensitivity increased up to 3% during irradiating seven times and decreased continuously above 8 times. That dropped by about 0.35 Gy per an irradiation. Finally, after 30 times irradiation, OSLDs sensitivity decreased by about 7%. For accumulated dose from 1 Gy to 5 Gy, OSLDs sensitivity about 1 Gy increased until 4.4% after second times accumulated dose compared with before that. OSLDs sensitivity about 1 Gy decreased by 1.6% in five times irradiation. When OSLDs were irradiated ten times with 1Gy after irradiating high dose (10, 15, 20 Gy), OSLDs sensitivity decreased until 6%, 9%, 12% compared with it before high dose irradiation, respectively. Conclusion: This study certified OSLDs sensitivity by accumulated dose and high dose. When irradiated with 1Gy, repeatedly, OSLDs sensitivity decreased linearly and the reduction rate of OSLDs sensitivity after high dose irradiation had dependence on irradiated dose.

  19. Experimental studies on radiation injury of the salivary gland

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Kazuko

    1987-06-01

    Parotid glands of male Wistar rats were irradiated. In the first group, the animals were irradiated by 4 fractions of 4 different daily doses ; 4.7 Gy, 5.7 Gy, 6.6 Gy and 7.4 Gy. Each dose corresponds to 30 Gy, 40 Gy, 50 Gy and 60 Gy by ordinary 2 Gy-a-day irradiation respectively in the estimation of TDF value. Degree of radiation injury and recovery of the parotid glands was examined histologically, and the area ratio (acini/total gland) was calculated at 1, 3 and 6 months after the completion of irradiation. In the second group, the animals were irradiated by the following schedule ; 10 fractions of 3.6 Gy daily (I-group) and 20 fractions of 1.8 Gy (II a-group), 2.2 Gy (II b-group) and 2.9 Gy (II c-group) twice-a-day, for 2 weeks, 5 days per week. Histological changes of parotid glands the irradiation, such as collapse of acini, degeneration of acinar cells, dilatation of ducts, fibrosis and fatty replacement were found. These changes increased corresponding to the absorbed dose. In 60 Gy-group the area ratio (acini/total gland) decreased with time, 1, 3 and 6 months after the irradiation (40 %, 20 % and 10 % of the control group, respectively), while, there was no remarkable change in 50 Gy-group (60 %) and 40 Gy-group (70 - 80 %). Whereas the area ratio in 30 Gy-group decreased at 1 and 3 months (80 - 85 %), it increased up to the nearly equal level of the control group at 6 months after the irradiation. It was suggested that the borderline dose which allowed the salivary gland to recover from radiation injury existed between 30 Gy and 40 Gy. The area ratio of II b-group at 1 and 3 months after the irradiation (50 %, 48 %) was nearly equal to that of I-group (53 %, 57 %). While the area ratio of II a-group (71 %, 73 %) was larger than that of I-group with a statistical significance. (J.P.N.).

  20. PENGARUH RADIASI SINAR GAMMA Co-60 TERHADAP STERILITAS DAN PERKEMBANGAN EMBRIO CULEX QUINQUEFASCIATUS

    Directory of Open Access Journals (Sweden)

    Riyani Setiyaningsih

    2015-05-01

    Full Text Available AbstrakTeknik Serangga Mandul merupakan teknik pengendalian vektor yang ramah lingkungan dan spesifi target. Aplikasi Teknik Serangga Mandul dalam pengendalian Cx quinquefasciatus belum pernah dilakukan di Indonesia, sehingga perlu uji pendahuluan sebelum aplikasi ke alam. Penelitian bertujuanmenentukan dosis optimal iradiasi sinar gamma Co-60 yang dapat mensterilkan dan berpengaruh terhadap perkembangan embrio Culex quinquefasciatus. Pupa jantan diradiasi dengan sinar gamma pada dosis 50 Gy, 50 Gy, 60 Gy, dan 70 Gy. Radiasi di lakukan di BATAN Jakarta. Nyamuk jantan yang muncul dari pupa kemudian di kawinkan dengan betina normal. Hasil perkawinan diamati sterilitas telur dan perkembangan embrio. Hasil penelitian menunjukkan sinar gamma Co-60 dosis 40 Gy, 50 Gy, 60 Gy, dan 70 Gy menyebabkan sterilitas telur yang dihasilkan 20,919%, 48,995%, 89,48%, dan 100%.Perlakuan dosis 40 Gy menghasilkan telur steril dengan 29,39% mengandung embrio dan 70,66% tidak mengandung embrio. Perlakuan dosis 50 Gy menghasilkan telur steril dengan 16,71% mengandung embrio dan 86,56% tidak mengandung embrio. Perlakuan dosis 60 Gy 9,35% telur steril mengandungembrio dan 90,64% tidak mengandung embrio. Perlakukan dosis 70 Gy 100 % telur yang dihasilkan steril dan tidak mengandung embrio. Dosis optimal yang dapat mensterilkan dan berpengaruh terhadap perkembangan embrio Culex quinquefasciatus adalah dosis 70 Gy.Kata kunci : Teknik Serangga Mandul, Culex quinquefasciatus dan sterilitasAbstractSterile Insect Tecnique is a vector control techniques that are environmentally safe and specifi targets. SIT application in the control of Cx quinquefasciatus has never been done in Indonesia, so we need a preliminary test before application to the nature. The aim of the study are to determine the optimal dose of gamma Co-60 radiation to sterilize and effect develop of embrio Culex quinquefasciatus. Male pupae radiated with gamma rays at a dose of 50 Gy, 50 Gy, 60 Gy, and 70 Gy

  1. Increased viability and resilience of haemolymph cells in blue mussels following pre-treatment with acute high-dose gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Jaeschke, B. [Stockholm University (Sweden)

    2014-07-01

    In an initial experiment, blue mussels (Mytilus edulis) were exposed to a range of acute high doses of gamma radiation in the laboratory. Haemolymph was extracted and the haemocytes (blood cells) were scored for cell viability (% living cells) under a microscope, directly after irradiation (0.04, 0.4 or 4 Gy) and again after a subsequent treatment with hydrogen peroxide in vitro (final H{sub 2}O{sub 2} conc.: 0.2 μM). Cell viability in controls (0 Gy) was approximately 100% and no cell death was observable from radiation exposure alone. When treated with H{sub 2}O{sub 2} a decrease in cell viability was seen across all treatments, however this decrease in viability was reduced with increasing radiation pre-treatment (0 Gy = 53%; 0.04 Gy = 66%; 0.4 Gy = 75%; 4 Gy = 83%). To investigate the mechanism for this therapeutic effect observed, the experiment was repeated. Using mussels from a different location, the same, but more extensive method of irradiation (0[control], 0.04, 0.4 Gy, 5 or 40 Gy) and H{sub 2}O{sub 2} treatment was used. Additional haemolymph sub-samples were taken for analysis of catalase concentration. In this second experiment, viability of cells from controls was only 62%, indicating the mussels were in a poorer condition than those of the previous experiment. The lowest level of radiation exposure (0.04 Gy) further decreased the viability (56%). However, at higher doses the viability was increased compared to control, which then gradually declined with increasing dose (0.4 Gy = 75%; 5 Gy = 72%; 40 Gy = 65%). Catalase analysis demonstrated a complimentary pattern of activity of the antioxidant in the haemolymph, directly correlating with radiation dose (0 Gy = 0.2 U; 0.04 Gy = 0.1 U; 0.4 Gy = 1.3 U; 5 Gy = 0.9 U; 40 Gy = 0.1 Gy). Treatment with H{sub 2}O{sub 2} decreased cell viability across all treatments, but no pattern between radiation treatments was discernable. The results indicate that an acute dose of radiation not only has negligible

  2. SU-E-T-69: A Radiobiological Investigation of Dose Escalation in Lower Oesophageal Tumours with a Focus On Gastric Toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Carrington, R [Cardiff University, Cardiff, Wales (United Kingdom); Staffurth, J; Spezi, E; Crosby, T [Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Warren, S; Partridge, M; Hawkins, M [CRUK/MRC Oxford Institute for Radiation Oncology, Oxford (United Kingdom); Gwynne, S [Singleton Hospital, Swansea, Wales (United Kingdom)

    2015-06-15

    The incidence of lower third oesophageal tumours is increasing in most Western populations. With the role of radiotherapy dose escalation being identified as a research priority in improving outcomes, it is important to quantify the increased toxicity that this may pose to sites such as the lower oesophagus. This study therefore aims to investigate the feasibility of lower oesophageal dose escalation with a focus on stomach tissue toxicity.The original 3D-conformal plans (50Gy3D) from 10 patients in the SCOPE1 trial were reviewed and compared to two RapidArc plans created retrospectively to represent the treatment arms of the forthcoming SCOPE2 trial: 50GyRA and 60GyRA (50Gy to PTV1 with a simultaneously integrated boost of 60Gy to PTV2). The stomach was contoured as stomach wall and dose constraints set according to QUANTEC. Normal tissue complication probability (NTCP) was estimated for the stomach wall for an endpoint of gastric bleeding. There was a mean increase of 5.93% in NTCP from 50Gy3D to 60GyRA and a mean increase of 8.15% in NTCP from the 50GyRA to 60GyRA. With NTCP modelling restricted to volumes outside PTV2, there was a mean decrease of 0.92% in NTCP from the 50Gy3D to 60GyRA, and a mean increase of 2.25% from 50GyRA to 60GyRA. There was a strong correlation between the NTCP and Stomach Wall/PTV1 overlap volume for all plans (R=0.80, 0.77 and 0.77 for 60GyRA, 50GyRA and 50Gy3D respectively). There was also a strong correlation between NTCP and the Stomach Wall/PTV2 overlap volume for 60GyRA (R= 0.82).Radiobiological modelling suggests that increasing the prescribed dose to 60Gy may be associated with a significantly increased risk of toxicity to the stomach within the boost volume. It is recommended that stomach toxicity be closely monitored prospectively when treating patients with lower oesophageal tumours in the forthcoming SCOPE 2 trial. Rhys Carrington received a PhD studentship grant from Cancer Research Wales. Grant number: 2445; Dr Warren and

  3. Decreasing the Dose to the Rectal Wall by Using a Rectal Retractor during Radiotherapy of Prostate Cancer: A Comparative Treatment Planning Study

    Directory of Open Access Journals (Sweden)

    Kristina Nilsson

    2014-01-01

    Full Text Available Aim. The aim of the study was to examine the dosimetric effect of rectal retraction, using a rectal retractor, by performing a comparative treatment planning study. Material and Methods. Treatment plans using volumetric arc therapy (VMAT were produced for ten patients both with and without rectal retraction. A hypofractionation scheme of 42.7 Gy in seven fractions was used. The dose to the rectal wall was evaluated for both methods (with and without retraction using four dose-volume criteria: V40.1 Gy, V38.3 Gy, V36.5 Gy, and V32.6 Gy. Results. The retraction of the rectal wall increased the distance between the rectal wall and the prostate. The rectal wall volume was reduced to zero for all dose-volume values except for V32.6 Gy, which was 0.2 cm3 in average when the rectal retractor was used. Conclusion. There was a significant decrease of V40.1 Gy, V38.3 Gy, V36.5 Gy, and V32.6 Gy when the rectal retractor was used without compromising the dose coverage of planning target volume (PTV.

  4. Effects of gamma radiation of Cobalt-60 on different phases of the evolutive cycle of pinworm - Tuta absoluta (Meyrich, 1917) (Lepidoptera,Gelechiidae); Efeitos da radiacao gama do Cobalto-60 nas diferentes fases do ciclo evolutivo da traca do tomateiro - Tuta absoluta (Meyrich, 1917) (Lepidoptera, Gelechiidae)

    Energy Technology Data Exchange (ETDEWEB)

    Groppo, Gerson Antonio

    1996-10-01

    The effects of different gamma radiation (Cobalt-60) doses on different phases of the evolutive cycle of Tuta absoluta (Meyrich, 1917) (Lepidoptera, Gelechiidae) have been studied under laboratory conditions in the laboratory of Entomology of Center for Nuclear Energy in Agriculture (CENA), University of Sao Paulo, Piracicaba, Sao Paulo State, Brazil. For all the treatments with gamma radiation a Cobalt-60 source type Gamma beam-650 was used. The doses utilized ranged from of 0,0 (Control) to 3250 Gy with a dose rate of 1110 Gy/h. The experiment was conducted under controlled conditions at 25{+-} 2 deg C, 70 {+-} 5% of relative humidity and photo period of (12:12). It was verified that the lethal doses were: for eggs - 70 Gy; for larvae - 200 Gy e for pupae - 300 Gy. The sterilizing dose for adults from irradiated larvae was 45 Gy. The sterilizing dose for the crossing of irradiated female with normal males (FI X MN) was 100 Gy and for normal female with irradiated male (FN x MI) was 150 Gy, in the both crosses, doses refer to irradiation of pupae. The sterilizing dose for adults, of both sexes, irradiated and crossed with normal adults, (FI x MN) and (FN x MI, were 150 and 200 Gy, respectively. The average longevity of adults, of both sexes, irradiated and crossed with normal adults was 8,3 days. The immediate lethal dose for adults was 3250 Gy. (author)

  5. Evaluation of exposure dose to patients undergoing catheter ablation procedures - a phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Seguchi, S. [Nagoya University, Graduate School of Medicine, Nagoya (Japan); Nagoya Daini Red Cross Hospital, Division of Radiology, Department of Medical Technology, Nagoya (Japan); Aoyama, T.; Koyama, S.; Kawaura, C. [Nagoya University, Graduate School of Medicine, Nagoya (Japan); Fujii, K. [Nagoya University, Graduate School of Medicine, Nagoya (Japan); National Institute of Radiological Sciences, Section of Radiological Protection, Chiba (Japan)

    2008-11-15

    The aim of this study was to evaluate entrance skin dose (ESD), organ dose and effective dose to patients undergoing catheter ablation for cardiac arrhythmias, based on the dosimetry in an anthropomorphic phantom. ESD values associated with mean fluoroscopy time and digital cine frames were in a range of 0.12-0.30 Gy in right anterior oblique (RAO) and 0.05-0.40 Gy in left anterior oblique (LAO) projection, the values which were less than a threshold dose of 2 Gy for the onset of skin injury. Organs that received high doses in ablation procedures were lung, followed by bone surface, esophagus, liver and red bone marrow. Doses for lung were 24.8-122.7 mGy, and effective doses were 7.9-34.8 mSv for mean fluoroscopy time of 23.4-92.3 min and digital cine frames of 263-511. Conversion coefficients of dose-area product (DAP) to ESD were 8.7 mGy/(Gy.cm{sup 2}) in RAO and 7.4 mGy/(Gy.cm{sup 2}) in LAO projection. The coefficients of DAP to the effective dose were 0.37 mSv/(Gy.cm{sup 2}) in RAO, and 0.41 mSv/(Gy.cm{sup 2}) in LAO projection. These coefficients enabled us to estimate patient exposure in real time by using monitored values of DAP. (orig.)

  6. Late effects and cosmetic results of conventional versus hypofractionated irradiation in breast-conserving therapy

    Energy Technology Data Exchange (ETDEWEB)

    Fehlauer, F.; Tribius, S.; Alberti, W.; Rades, D. [Dept. of Radiation Oncology, Univ. Medical Clinic Hamburg-Eppendorf, Hamburg (Germany)

    2005-10-01

    Background and purpose: breast irradiation after lumpectomy is an integral component of breast-conserving therapy (BCT). As the prognosis is general good following BCT, late morbidity and cosmesis are important. The present study compares two different radiation schedules with respect to these two endpoints. Patients and methods: 129 breast cancer patients (pT1-2 pN0-1 cM0) were irradiated between 09/1992 and 08/1994 with either a 22-day fractionation schedule (2.5 Gy to 55 Gy, 4 x /week, n = 65) or with a conventional fractionation schedule (28 days, 2.0 Gy to 55 Gy, 5 x /week, n = 64), both without additional boost. The equivalent dose of 2-Gy fractions (EQD2) was 55 Gy and 62 Gy, respectively. Late toxicity, assessed according to the LENT-SOMA criteria, and cosmetic outcome, graded on a 5-point scale, were evaluated after a median of 86 months (range 72-94 months) in tumor-free breast cancer patients. Results: LENT-SOMA grade 2/3 toxicity (2.5 Gy vs. 2.0 Gy): breast pain (18% vs. 11%; p = 0.3), fibrosis (57% vs. 16%; p < 0.001), telangiectasia (22% vs. 3%; p = 0.002), atrophy (31% vs. 3%; p < 0.001). Medication to breast pain was taken by 8% versus 9% of patients. Cosmesis was very good/good/acceptable in 75% versus 93% (2.5 Gy vs. 2.0 Gy; p = 0.006). Conclusion: late morbidity was significantly frequent and cosmesis was significantly worse after hypofractionated radiotherapy (2.5 Gy to 55 Gy). However, morbidity was not associated with major implications on daily life. (orig.)

  7. Effect of different ionizing radiation dose rates on the Staphylococcal enterotoxin in mechanically deboned chicken meat

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, Heliana de; Brito, Poliana de Paula; Fukuma, Henrique Takuji; Roque, Claudio Vitor; Custodio, Wilson [Brazilian Nuclear Energy Commission (CNEN-MG), Pocos de Caldas, MG (Brazil)], e-mail: hazevedo@cnen.gov.br, e-mail: pbrito@cnen.gov.br, e-mail: cvroque@cnen.gov.br, e-mail: htfukuma@cnen.gov.br, e-mail: wilsonc@cnen.gov.br; Kodama, Yasko [Nuclear and Energy Research Institute (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)], e-mail: ykodama@ipen.br; Miya, Norma Terugo Nago; Pereira, Jose Luiz [Campinas State University (UNICAMP), SP (Brazil). Dept. of Food Sciences], e-mail: pereira@fea.unicamp.br, e-mail: miya@fea.unicamp.br

    2009-07-01

    Samples weighing 50g each were prepared from allotments of back with skin MDCM, to the EEB contamination or not (control). Each sample of MDCM contaminated or not with EEB was conditioned in low density polyethylene bag, frozen (-18 {+-} 1 deg C) for one night in a tunnel and irradiated with gamma rays from {sup 60}Co source in this state with doses of 0.0 kGy (control), 1.5 kGy (5.7 kGy.h{sup -1} - higher dose rate, 1.8 kGy.h{sup -1} - intermediary dose rate and 0.6 kGy.h{sup -1} - lower dose rate) and 3.0 kGy (8.4 kGy.h{sup -}'1 - higher dose rate, 2.4 kGy.h{sup -1} - intermediary dose rate and 0.6 kGy.h{sup -1} - lower dose rate). Irradiated or non irradiated MDCM samples were processed to the EEB extraction, according to the VIDAS Staph enterotoxin II kit (bioMerieux) manufacturer protocol. The calculation to determinate the MDCM EEB recovery after the sample (control or irradiated) processing were carried out applying the principle of mass balance, along the whole process. Described experiment was performed in triplicate. Results showed that the irradiation process was effective to remove the MDCM EEB, to both 1.5 kGy and 3.0 kGy. According to the expected, doses of 3.0 kGy showed the highest values of MDCM EEB removal. Regarding the effect of dose rate of radiation on the removal of EEB of the MDCM, it could be observed only for samples irradiated with 1.5 kGy radiation dose; in these processing conditions, the highest value of EEB removal was obtained for samples processed with low radiation dose rate. (author)

  8. Evaluation of patient radiation doses using DAP meter in interventional radiology procedures

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Byung Sam [Dept. of Radiological Technology. Shingu University, Sungnam (Korea, Republic of); Yoon, Yong Su [Dept. of Health Sciences, Graduate School of Medical Sciences, Kyushu Univeristy, Kyushu (Japan)

    2017-03-15

    The author investigated interventional radiology patient doses in several other countries, assessed accuracy of DAP meters embedded in intervention equipment in domestic country, conducted measurement of patient doses for 13 major interventional procedures with use of Dose Area Product(DAP) meters from 23 hospitals in Korea, and referred to 8,415 cases of domestic data related to interventional procedures by radiation exposure after evaluation the actual effective of dose reduction variables through phantom test. Finally, dose reference level for major interventional procedures was suggested. In this study, guidelines for patient doses were 237.7 Gy·cm{sup 2} in TACE, 17.3 Gy·cm{sup 2} in AVF, 114.1 Gy·cm{sup 2} in LE PTA and STENT, 188.5 Gy·cm{sup 2} in TFCA, 383.5 Gy·cm{sup 2} in Aneurysm Coil, 64.6 Gy·cm{sup 2} in PTBD, 64.6 Gy·cm{sup 2} in Biliary Stent, 22.4 Gy·cm{sup 2} in PCN, 4.3 Gy·cm{sup 2} in Hickman, 2.8 Gy·cm{sup 2} in Chemo-port, 4.4 Gy·cm{sup 2} in Perm-Cather, 17.1 Gy·cm{sup 2} in PCD, and 357.9 Gy·cm{sup 2} in Vis, EMB. Dose reference level acquired in this study is considered to be able to use as minimal guidelines for reducing patient dose in the interventional radiology procedures. For the changes and advances of materials and development of equipment and procedures in the interventional radiology procedures, further studies and monitoring are needed on dose reference level Korean DAP dose conversion factor for the domestic procedures.

  9. SU-E-J-83: CBCT Based Rectum and Bladder Dose Tracking in the Prostate Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Z; Wang, J; Yang, Z; Hu, W [Fudan University Shanghai Cancer Center, Shanghai (China)

    2015-06-15

    Purpose: The aim of this study is to monitor the volume changes of bladder and rectum and evaluate the dosimetric changes of bladder and rectum using daily cone-beam CT for prostate radiotherapy. Methods: The data of this study were obtained from 12 patients, totally 222 CBCTs. All the volume of the bladder and the rectum on the CBCT were normalized to the bladder and the rectum on their own original CT to monitory the volume changes. To evaluate dose delivered to the OARs, volumes that receive 70Gy (V70Gy), 60Gy, 50Gy, 40Gy and 30Gy are calculated for the bladder and the rectum, V20Gy and V10Gy for rectum additionally. And the deviation of the mean dose to the bladder and the rectum are also chosen as the evaluation parameter. Linear regression analysis was performed to identify the mean dose change of the volume change using SPSS 19. Results: The results show that the variances of the normalize volume of the bladder and the rectum are 0.15–0.58 and 0.13–0.50. The variances of V70Gy, V60Gy, V50Gy, V40Gy and V30Gy of bladder are bigger than rectum for 11 patients. The linear regression analysis indicated a negative correlation between the volume and the mean dose of the bladder (p < 0.05). A 10% increase in bladder volume will cause 5.1% (±4.3%) reduction in mean dose. Conclusion: The bladder volume change is more significant than that for rectum for the prostate cancer patient. The volume changes of rectum are not significant except air gap in the rectum. Bladder volume varies will cause significant dose change. The bladder volume monitoring before fractional treatment delivery would be crucial for accuracy dose delivery.

  10. 洛杉矶诗人

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    由于洛杉矶Getty中心的“朱利叶斯·舒而曼(Julius Shulman)现代与都市“展览的开幕.标志着该博物馆获得了大量的摄影师作品260000张底片、照片和幻灯片,它们本质上见证了战后南加利福利亚建筑史上的发展.这次所收集的作品包括鲁道夫·辛德勒(Rudotf Schindler).弗兰克·劳埃德·赖特(Frank Lloyd Wright)、查尔斯(Charles)、雷·艾姆斯(Ray Eames)和理查德·诺依特拉(Richard Neutra)。

  11. 'Magic coins' and 'magic squares': the discovery of astrological sigils in the Oldenburg Letters.

    Science.gov (United States)

    Roos, Anna Marie

    2008-09-20

    Enclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637-1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modem beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities.

  12. 世界化妆品业的微生物专家——专访德国舒美有限公司中国地区经理石春霄先生

    Institute of Scientific and Technical Information of China (English)

    李俪瑛

    2007-01-01

    1889年,Rudolf Sch ü Ike和Julius Mayr在德国汉堡创建了德国舒美有限公司(Sch ü Ike&Mayr GmbH)。同年向市场推出了全球第一个品牌消毒剂——来苏水(LYSOL*)。1892年,汉堡爆发了大规模的流行性传染病霍乱,LYSOL*战胜了霍乱,挽救了无数人的生命,舒美也因此被当时的汉堡市政厅授予了荣誉奖章。

  13. History of the ductus arteriosus: 2. Persisting patency in the preterm infant.

    Science.gov (United States)

    Obladen, Michael

    2011-01-01

    By 1769, it was known to Morgagni that the ductus arteriosus may persist until adulthood. In 1835, Jörg linked delayed postnatal closure with disturbed respiration, a discovery that was afterwards forgotten for a century. When blood gas analysis became available, the association between persisting patency and diminished oxygenation resurfaced. When it became known that prostaglandins played a role in maintaining ductal patency, the development of pharmacologic intervention with cyclooxygenase inhibitors immediately followed. This rapid progress was due to the interaction between basic science, pediatric cardiology, and neonatology disciplines at the Cardiovascular Research Institute in San Francisco, coordinated by Julius Comroe, as well as President Kennedy's foundation of the National Institute of Child Health and Development. This series of events exemplifies how clinical research became an integrated managed multidisciplinary endeavor in the 20th century.

  14. QUANTUM @ Théâtre Forum Meyrin | 30-31 October

    CERN Multimedia

    2015-01-01

    The Gilles Jobin Company has the pleasure of welcoming you to QUANTUM @ Théâtre Forum Meyrin.   QUANTUM @ Théâtre Forum Meyrin Friday, 30 October - 8.30 p.m.  Saturday, 31 October - 7.00 p.m. SPECIAL PRICE FOR CERN PERSONNEL: 15 CHF upon presentation of your CERN card (regular price: 25 CHF/20 CHF). QUANTUM is a "creative collision" between 2012 Arts@CERN resident artists Gilles Jobin, choreographer, and Julius Von Bismarck, visual artist. Von Bismarck's lumino-kinetic installation lights up the stage while Carla Scaletti's music score uses real LHC "sonified" data! Physicists Michael Doser and Nicholas Chanon participated in the creation as scientific advisors to the choreographer. Created at the CMS ex...

  15. Mitral regurgitation: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Ejiofor JI

    2016-05-01

    Full Text Available Julius I Ejiofor, Lawrence Cohn,† Tsuyoshi Kaneko Division of Cardiac Surgery, Brigham and Women’s Hospital, Boston, MA, USA †Lawrence Cohn passed away on January 9, 2016 Abstract: Since the first mitral valvuloplasty in 1923, the technique of mitral valvuloplasty has matured over the years and now has become the first-line treatment, especially in patients with myxomatous mitral regurgitation (MR. We have highlighted some of the major problems that are encountered with the various etiologies of MR. We believe that repair is always the optimal surgical procedure for any of the above etiologies if it is consistent with a long-term result. However, replacement has shown to be a safer procedure in some instances such as severe functional MR or destructive endocarditis. Keywords: mitral regurgitation, mitral valvuloplasty, systolic anterior motion, functional mitral regurgitation, rheumatic valve disease

  16. Spa Garden in Daruvar – Methods of Renewal and Reconstruction

    Directory of Open Access Journals (Sweden)

    Šćitaroci Mladen Obad

    2014-12-01

    Full Text Available Spa garden in Daruvar ‘Julius’s Park’ is the oldest spa garden in continental Croatia. The counts Jankovich and their successors created the garden during the 18th and 20th century. The garden resumed its nowadays form and surface in the time of count Julius Jankovich in the mid-19th century and it was named after him. The garden is protected as a cultural heritage. The garden’s renovation is seen as an urban, architectural and landscape unity and it attempts to affirm the missing and neglected parts of the garden, to provide technological and municipal space modernization and to make a pleasant urban garden ambiance with new facilities and high space arrangement qualities, contributing to the economic development of the local community.

  17. The effect of macroeconomic variables on non performance financing of Islamic Banks in Indonesia

    Directory of Open Access Journals (Sweden)

    Latifah Dian Iriani

    2015-10-01

    Full Text Available This research is going to discuss about the determinant macro variables and bank’s behavior determinant credit risk on Islamic rural bank in Indonesia. It could be seen on macro variables such as inflation, exchange rate, Jakarta I slamic index (JII and money supply (M2, and bank’s behavior such as financing. Research methodology used at this study is Vector Error Correction Model (VECM. Following these procedures, it applies Unit Roots Test, Augmented Dickey Fuller Test, Lag Length Criteria Test, Correlation Matrix – Johansen Julius Co-integration Test, VECM Estimation, Impulse Response and Variance Decomposition Test. The result show that both bank behaviors and macroeconomic variables are significant affecting non-performing financing (NPF. The banking need more careful to manage internal and external factors that influence non-performing financing (NPF.

  18. Steni muinasjutuvõistluse võitjad selgunud / Ants Roos, Ann Roos

    Index Scriptorium Estoniae

    Roos, Ants

    2008-01-01

    Steni XVI muinasjutuvõistluse žüriisse kuulusid: Ann Roos, Ants Roos, Leelo Tungal, Krista Kumberg, Leida Olszak, Ülle Väljataga. Tulemused: I koht Siim Niinelaid, II koht Julius Air Kull, III koht Mihkel Rammu. Žürii eriauhinnad: Anna Kristin Peterson, Elis Ruus, Rain Hallikas, Mariliis Peterson, Marjaliisa Palu, Karl Kirsimäe, Margaret Pulk. Ergutusauhinnad: Karmel Klaus, Martti Kaljuste, Kristina Korell, Mirjam Võsaste, Mihkel Põder, Iirys Kalde, Miriam Jamul, Mari-Ann Mägi, Ketlin Saar, Liisbeth Kirss. Muud eriauhinnad said: Allan Läll, Berle Mees, Anett Kuuse, Karl Erik Kübarsepp, Grete Tamm, Siim Niinelaid, Kaisa Marie Sipelgas, Ellen Anett Põldmaa, Evelin Laul, Karl Laas, Karl Stamm, Kerli Retter

  19. 源自古罗马文化的趣味习语

    Institute of Scientific and Technical Information of China (English)

    赵翔

    2009-01-01

    公元前55年,古罗马统帅恺撒(Julius Caesar)在征服高卢(Gaul)之后来到不列颠岛,但并未同当地的凯尔特人(Celts)发生冲突。第二年,恺撒第二次亲临不列颠。这次他在不列颠岛东南部站稳了脚跟,并与当地的凯尔特人发生冲突。恺撒大军虽然取胜,但并没有使凯尔特人屈服,古罗马也没有对不列颠岛的社会文化产生大的影响。

  20. Narrative plots of teaching mathematics to improve the breed in Colombian society

    Directory of Open Access Journals (Sweden)

    Néstor Fernando Guerrero Recalde

    2016-06-01

    Full Text Available This article seeks to show the reasons which have led to consider the school as a privileged institution for the civilizing process. In particular understand the reasons which have led to argue that mathematical knowledge are key to the formation of the civilized individual parts. To account for this thesis was chosen in the history of Colombia the period 1873-1960, which have called period of "eugenic math" or "period of improving the race." In this period we are oriented to eliminate those features of our society seen as savage and barbaric speech. Also, this speech was accompanied with the idea of building a new republic from scientific educational devices. The most prominent figure in this period were the german physical and mathematical Julius Sieber.

  1. The Beginnings and Development of the Collection of Historic Musical Instruments of the Kunsthistorisches Museum in Vienna

    Directory of Open Access Journals (Sweden)

    Beatrix Darmstaedter

    2016-12-01

    Full Text Available The Collection of Historic Musical Instruments of the Kunsthistorisches Museum in Vienna (KHM was founded during the First World War when the inventories of the collections owned by Archduke Franz Ferdinand of Austria-Este (1863-1914 went to the Imperial museum in Vienna after his assassination. From 1916/17 on, the renowned art historian Julius von Schlosser (1866-1938 and his successor, Hermann Julius Hermann (1869-1953, organized one of the most important collections and exhibitions exclusively dedicated to musical instruments. They assembled valuable items from the 16th century that had belonged to Archduke Ferdinand II’s (1529-1595 Cabinet of Curiosities, objects collected by members of the Obizzi dynasty in the castle of Catajo, and recently acquired historical instruments connected with the Viennese tradition of instrument making. In 1920, Schlosser wrote his fundamental catalogue on the newly established collection that  is considered to be the fi rst systematical and scientifi c publication on historic musical instruments in Austria. During the following years, he strove towards amplifying the inventory and expanding the exhibition. He transferred precious items originally belonging to the movables depot of the erstwhile court (Hofmobiliendepot and instruments left in former imperial residences, such as the castle of Laxenburg. The contribution reviews previously unpublished archived sources documenting the early history of the collection and broaches the issue of the extended exhibition in the 1920s, discusses the thematic orientations of the collection and the principles in museum didactic that consequently arose. Moreover, the position of the collection and its policy in the context of other museums with similar emphases at that time will be analyzed. La collezione di strumenti musicali antichi del Kunsthistorisches Museum a Vienna (KHM é stata fondata durante la prima guerra mondiale quando l’inventario delle collezioni dell

  2. Bruno Zumino (1923 - 2014)

    CERN Multimedia

    2014-01-01

    Bruno Zumino died in Berkeley, California, on 21* June, aged 91. His name is mainly associated with the formulation of supersymmetry in four-dimensional space–time.   Bruno Zumino in 1985. (Image credit: Lawrence Berkeley National Laboratory.) Zumino graduated in physics at the University of Rome in 1945 and worked in Göttingen and then at New York University, where he became Chair of the Physics Department. In 1968, he joined the Theory Division at CERN, staying until 1981. It was here that he did his pioneering work with Julius Wess of Karlsruhe in which they formulated the first supersymmetric four-dimensional quantum field theory – the Wess–Zumino model – in 1974. Today supersymmetry is a strong candidate for physics beyond the Standard Model and provides some candidate particles for dark matter. In 1976, two years after its formulation, supersymmetry was combined with the gravitational force, giving birth to supergravity and stunning deve...

  3. Steni muinasjutuvõistluse võitjad selgunud / Ants Roos, Ann Roos

    Index Scriptorium Estoniae

    Roos, Ants

    2008-01-01

    Steni XVI muinasjutuvõistluse žüriisse kuulusid: Ann Roos, Ants Roos, Leelo Tungal, Krista Kumberg, Leida Olszak, Ülle Väljataga. Tulemused: I koht Siim Niinelaid, II koht Julius Air Kull, III koht Mihkel Rammu. Žürii eriauhinnad: Anna Kristin Peterson, Elis Ruus, Rain Hallikas, Mariliis Peterson, Marjaliisa Palu, Karl Kirsimäe, Margaret Pulk. Ergutusauhinnad: Karmel Klaus, Martti Kaljuste, Kristina Korell, Mirjam Võsaste, Mihkel Põder, Iirys Kalde, Miriam Jamul, Mari-Ann Mägi, Ketlin Saar, Liisbeth Kirss. Muud eriauhinnad said: Allan Läll, Berle Mees, Anett Kuuse, Karl Erik Kübarsepp, Grete Tamm, Siim Niinelaid, Kaisa Marie Sipelgas, Ellen Anett Põldmaa, Evelin Laul, Karl Laas, Karl Stamm, Kerli Retter

  4. The clinical utility of FibroScan® as a noninvasive diagnostic test for liver disease

    Directory of Open Access Journals (Sweden)

    Wilder J

    2014-05-01

    Full Text Available Julius Wilder,1,2 Keyur Patel1,21Division of Gastroenterology, Duke University School of Medicine, 2Duke Clinical Research Institute, Durham, NC, USAAbstract: An important aspect of managing chronic liver disease is assessing for evidence of fibrosis. Historically, this has been accomplished using liver biopsy, which is an invasive procedure associated with risk for complications and significant sampling and observer error, limiting the accuracy for determination of fibrosis stage. Hence, several serum biomarkers and imaging methods for noninvasive assessment of liver fibrosis have been developed. In this article, we review the current literature on an important noninvasive imaging modality to measure tissue elastography (FibroScan®. This ultrasound-based technique is now increasingly available in many countries and has been shown to be a reliable and safe noninvasive means of assessing disease severity in chronic liver disease of varying etiology.Keywords: elastography, ultrasound, fibrosis, cirrhosis

  5. A minimal model of metabolism-based chemotaxis.

    Directory of Open Access Journals (Sweden)

    Matthew D Egbert

    Full Text Available Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent studies have shown, however, that many metabolism-dependent chemotactic patterns occur in bacteria. We hereby present the simplest artificial protocell model capable of performing metabolism-based chemotaxis. The model serves as a proof of concept to show how even the simplest metabolism can sustain chemotactic patterns of varying sophistication. It also reproduces a set of phenomena that have recently attracted attention on bacterial chemotaxis and provides insights about alternative mechanisms that could instantiate them. We conclude that relaxing the metabolism-independent assumption provides important theoretical advances, forces us to rethink some established pre-conceptions and may help us better understand unexplored and poorly understood aspects of bacterial chemotaxis.

  6. Perception of the Relevance of Organic Chemistry in a German Pharmacy Students' Course.

    Science.gov (United States)

    Wehle, Sarah; Decker, Michael

    2016-04-25

    Objective. To investigate German pharmacy students' attitudes toward the relevance of organic chemistry training in Julius Maximilian University (JMU) of Würzburg with regard to subsequent courses in the curricula and in later prospective career options. Methods. Surveys were conducted in the second-year organic chemistry course (50 participants) as well as during the third-year and fourth-year lecture cycle on medicinal and pharmaceutical chemistry (66 participants) in 2014. Results. Students' attitudes were surprisingly consistent throughout the progress of the degree course. Students considered organic chemistry very relevant to the pharmacy study program (95% junior and 97% senior students), and of importance for their future pharmacy program (88% junior and 94% senior students). With regard to prospective career options, the perceived relevance was considerably lower and attitudes were less homogenous. Conclusions. German pharmacy students at JMU Würzburg consider organic chemistry of high relevance for medicinal chemistry and other courses in JMU's pharmacy program.

  7. [Welcome to the DGN Congress].

    Science.gov (United States)

    Reichmann, Heinz

    2017-08-01

    Liebe Kolleginnen und Kollegen, ich möchte dieses Editorial nutzen, um Sie ganz herzlich, auch im Namen der Deutschen Gesellschaft für Neurologie, zum Jahreskongress unserer Gesellschaft vom 20. – 23.09.17 nach Leipzig einzuladen. Der Wissenschaftsstandort Leipzig darf auf herausragende Fachkollegen zurückblicken. So hat Wilhelm Erb 1880 als Professor der Medizinischen Poliklinik die Neurologie als eigenständiges Lehrfach entwickelt und hatte das Privileg, mit den Neurowissenschaftlern Paul Flechsig und Paul Julius Möbius zusammen zu arbeiten. Das Team um Herrn Prof. Claßen, Kongresspräsident, und Frau Prof. Saur, Kongresssekretärin, hat zusammen mit dem Programm-Komitee der Deutschen Gesellschaft für Neurologie ein außerordentlich spannendes und vielfältiges Programm zusammen gestellt.

  8. Species-specific cell mobility of bacteria-feeding myxamoebae in plasmodial slime molds.

    Science.gov (United States)

    Hoppe, Thomas; Kutschera, Ulrich

    2015-01-01

    On decaying wood or litter in forests, plasmodial slime molds (myxomycetes) represent a large fraction of eukaryotic protists that feed on bacteria. In his seminal book Experimental Physiology of Plants (1865), Julius Sachs referred to the multinucleate plasmodium of myxomycetes, which were considered at that time as primitive plants (or fungi). Today it is well established that myxomycetes are members of the Amoebozoa (Protista). In this study we compare the mobility of myxamoebae of 3 European species, Lycogala epidendrum (order Liceales), Tubulifera arachnoidea, and Trichia decipiens (order Trichiales). Using agar plates, on which 3 separate bacterial species were cultivated as prey organisms (Methylobacterium mesophilicum, Escherichia coli, Agrobacterium tumefaciens), we document large differences in cell motility between the myxomycetes investigated. In addition, we show that the 3 species of myxamoebae can be distinguished based on their average cell size. These data shed light on the mode of co-occurrence via differential substrate utilization in these members of the Amoebozoa.

  9. Teju Cole's Nigeria and the open cities of New York and Brussels

    Directory of Open Access Journals (Sweden)

    Igor Maver

    2013-12-01

    Full Text Available The novel Open City (2011 by the Nigerian-born and raised author Teju Cole isset in New York City, where he has lived since 1992. The narrator and protagonist of the book, the young Nigerian doctor Julius in is a veritable flâneur in the Big Apple, who is observing the rapidly changing multiethnic character of the city and meditating on (his history and culture, identity and solitude, and the world beyond the United States, with which it is interconnected through the global history of violence and pain. He is juxtaposing the past and the present, the seemingly borderless open city of New York, Nigeria, and the various European locales, particularly Brussels.Thenovel, although set in the United States, is constantly interspersed with his recollections of his past experiences conditioned by hiscomplex hybrid Nigerian-European-American identity.

  10. Ernst Kris. Le Style rustique

    OpenAIRE

    Darragon, Eric

    2012-01-01

    Surtout connu en français pour son ouvrage sur L’Image de l’artiste écrit en collaboration avec Otto Kurz, l’auteur de Style rustique —titre subtilement inopérant et dissonant par rapport à Heinrich Wölfflin ou W. Friedländer— mérite de trouver sa place parmi les maîtres de l’école de Vienne. Disciple de Julius von Schlosser, Ernst Kris est un esprit précoce qui s’intéresse à la sculpture et aux arts décoratifs. Il devient un excellent connaisseur de ces objets très présents dans les collecti...

  11. 威尔豪森对早期以色列历史的研究%Wellhausen's Study of Early Israel History

    Institute of Scientific and Technical Information of China (English)

    陈贻绎

    2013-01-01

    This paper discusses the works and methodology of German biblical scholar Julius Wellhausen. His masterpeice is Prolegomena to the History of Israel. By summing up his predecessors' research work, he improved the well-known"documentary hypothesis".%威尔豪森最具代表性的作品是《以色列历史绪论》(Prolegomena to the History of Israel),最主要的贡献是立足于对前人学说总结的基础上,完善了著名的“五经四源”(Documentary Hypothesis)学说。他在以色列历史研究领域具有革命性的深远影响。

  12. The evil that men do-an open letter to President Obama

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-05-01

    Full Text Available No abstract available. Article truncated after 150 words. "The evil that men do lives after them; the good is oft interred with their bones". William Shakespeare. Julius Caesar, Act 3, Scene 2. Dear President Obama: Late in a second term, a President's attention often turns to framing their legacy. I suspect you are no exception and have given this considerable thought. You might wish to be remembered for the Affordable Care Act, even called Obamacare, which brought the US closer to universal healthcare coverage. However, I recall the end of President Clinton's second term a short 16 years ago. During that administration the Federal coffers were full; an unprecedented business boom occurred; and foreign entanglements that might have led to war were avoided. However, most of us do not remember those positives, but recall a White House intern and a certain blue dress. As pointed out by Shakespeare over 400 years ago powerful men are remembered not so ...

  13. The biochemistry of memory.

    Science.gov (United States)

    Stock, Jeffry B; Zhang, Sherry

    2013-09-09

    Almost fifty years ago, Julius Adler initiated a program of research to gain insights into the basic biochemistry of intelligent behavior by studying the molecular mechanisms that underlie the chemotactic responses of Escherichia coli. All living organisms share elements of a common biochemistry for metabolism, growth and heredity - why not intelligence? Neurobiologists have demonstrated that this is the case for nervous systems in animals ranging from worms to man. Motile unicellular organisms such as E. coli exhibit rudimentary behaviors that can be loosely described in terms of cognitive phenomena such as memory and learning. Adler's initiative at least raised the prospect that, because of the numerous experimental advantages provided by E. coli, it would be the first organism whose behavior could be understood at molecular resolution.

  14. Saturn and How to Observe it

    CERN Document Server

    Benton, Julius L

    2005-01-01

    Saturn is the second largest planet in the solar system, and the only one with a spectacular ring system easily visible from Earth. Julius Benton's Saturn and How to Observe It provides a compendium of the latest information, amateur and professional images of Saturn. These images are followed by advice on how to observe Saturn using a variety of telescope apertures, color filters and magnifications. This text is a goldmine of information for all levels of amateur observers, from the beginner to the highly experienced. Brought to life by crisp color photographs, Saturn and How to Observe It is a modern comprehensive review of Saturn as a planet and its magnificent ring system. The book includes some of the latest detailed theories and physical descriptions of Saturn and its satellites. The techniques for observing Saturn are outlined in this book, giving the reader a thorough explanation of what they are viewing.

  15. The Captivating Beauty of the Divine Spark—Breslau and the Reception of Yehuda Halevi’s Sefer Kuzari (1877–1911

    Directory of Open Access Journals (Sweden)

    Kohler George Y.

    2016-03-01

    Full Text Available The article follows the reception of the philosophy of Yehudah Halevi (1075–-1141 within the Breslau school of Jewish thought during the second half of the nineteenth century. Special focus is given to the discussion of Halevi in the writings of David Kaufmann and Julius Guttmann. Both scholars admire Halevi’s Sefer haKuzari because they discovered a certain analogy between his medieval project of an intellectual apology of Judaism and their own endeavors in Breslau to philosophically justify the existence of Judaism in modernity. In their point of view, Halevi has achieved his results, however, without forcing the wealth of traditional Jewish teachings into an artificial system of thought, as did Maimonides after him. Thus, Halevi became for the Breslau scholars a personal example of Jewish integrity, combining faithful adherence to Judaism with intellectual penetration of its doctrines.

  16. Noncommutative Gravity and Quantum Field Theory on Noncommutative Curved Spacetimes

    CERN Document Server

    Schenkel, Alexander

    2012-01-01

    The focus of this PhD thesis is on applications, new developments and extensions of the noncommutative gravity theory proposed by Julius Wess and his group. In part one we propose an extension of the usual symmetry reduction procedure to noncommutative gravity. We classify in the case of abelian Drinfel'd twists all consistent deformations of spatially flat Friedmann-Robertson-Walker cosmologies and of the Schwarzschild black hole. The deformed symmetry structure allows us to obtain exact solutions of the noncommutative Einstein equations in many of our models. In part two we develop a new formalism for quantum field theory on noncommutative curved spacetimes by combining methods from the algebraic approach to quantum field theory with noncommutative differential geometry. We also study explicit examples of deformed wave operators and find that there can be noncommutative corrections even on the level of free field theories. The convergent deformation of simple toy models is investigated and it is found that ...

  17. [Treatment of syphilis with malaria or heat].

    Science.gov (United States)

    Verhave, Jan Peter

    2016-01-01

    Until the end of the Second World War, syphilis was a common sexually transmitted infection. This stigmatising infectious disease caused mental decline, paralysis and eventually death. The history of syphilis was given public attention because of 'malaria therapy', which had been applied from the First World War onwards in patients with paralytic dementia. In 1917, the Austrian physician Julius Wagner-Jauregg (1857-1940) induced fever in these patients by infecting them with malaria parasites; in 1927, he received the Nobel Prize for his discovery of the healing properties of malarial fever. One source, not cited anywhere, is an interview that the American bacteriologist and science writer/medical journalist Paul de Kruif conducted with Wagner-Jauregg in 1930. The reporting of this meeting, and De Kruif's later involvement in the mechanical heat treatment of patients with syphilis, form the inspiration for this article. When penicillin became available, both treatments became obsolete.

  18. Berengario da Carpi.

    Science.gov (United States)

    De Santo, N G; Bisaccia, C; De Santo, L S; De Santo, R M; Di Leo, V A; Papalia, T; Cirillo, M; Touwaide, A

    1999-01-01

    Berengario da Carpi was magister of anatomy and surgery at the University of Bologna from 1502 to 1527. Eustachio and Falloppia defined him as 'the restaurator of anatomy'. He was a great surgeon, anatomist and physician of illustrious patients including Lorenzo II dei Medici, Giovanni dalle Bande Nere, Galeazzo Pallavicini, Cardinal Colonna, and Alessandro Soderini. He had strong links to the intellectuals of his time (Forni, Bonamici, Manuzio, Pomponazzi) as well as with the Medici family. He was respected by the Popes Julius II, Leo X and Clement VII. His main contributions are the Isogogae Breves, De Fractura calvae sive cranei, and the illustrated Commentaria on the Anatomy of Mondino de Liucci, a textbook utilized for more than 200 years, which Berengario aimed to restore to its initial text. The Commentaria constitutes the material for the last part of this paper which concludes with a personal translation of some passages on 'The kidney', where the author gives poignant examples of experimental ingenuity.

  19. 西方史上代价高昂de八大艳遇

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    古罗马皇帝朱里斯·恺撒(Julius·Caesar)与埃及王后克莉奥帕特(Cleopatra VII)//古罗马统帅马克·安东尼(Mark·Antony)与埃及王后克莉奥帕特拉(Cleopatra VII)//湿莎(Windsor)公爵与歌剧演员沃丽斯·沃菲尔德//美国第35任总统 约翰·菲茨杰拉德·肯尼迪(John·Fitzgerald·Kennedy)与玛丽莲·梦露(Harilyn·Monroe)//美国第42任总统比尔·克林顿(William·Jefferson·Clinton)与莫妮卡·莱温斯基(Monica·Lewinski)

  20. About furniture. Before and after Ptolomaeus Philadelphos' pavilion

    Directory of Open Access Journals (Sweden)

    Elena Calandra

    2010-07-01

    Full Text Available The furniture is of primary importance towards the canopies definition, more than the architectonic structure: they  contribute, in fact, in creating and organizing the spaces, so that there is almost no distinction between furniture and structure, as it is possible to observe in the ancient sources of different periods (Herodotus, Euripides, Julius Caesar, Plutarchus, Athenaeus: the pavilions of Xerxes at Plataia, of Ion at Delphi, of Alexander after the Issa battle and at Susa, of Pompey at Pharsalos, as well as the Ptolomaeus's canopy at Alexandria. At the same time, the furniture language is studied, signifying the power and the force of the sovereign through the luxurious materials and surprising the spectators.      At the end, some hypotheses on the final destination of the furniture, after dismantling the Ptolomaeus' canopy, equiped for one year.