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Sample records for jules verne atv

  1. ATV "Jules Verne" Tests Campaign at ESA

    Science.gov (United States)

    Pery, V.; Bouchery, J.-P.; Le Querrec, L.; Maurel, E.; Ruffino, F.

    2004-08-01

    This paper provides with an overview of the ATV first flight model tests campaign that is to take place at ESTEC Test Centre between summer 2004 and mid- 2005. The ATV vehicle mission, configuration and development logic are first briefly described. The campaign sequence and purposes are then outlined together with the main tests principles and objectives. Some of the main constraints that drive the campaign preparation and performance as well as some particular safety aspects are finally defined.

  2. Space Debris Conjunction Risk Assessment for the ATV-Jules Verne Mission

    Science.gov (United States)

    Delavault, S.; Dupuis, G.; Perrachon, P.

    2009-03-01

    This paper focuses on the collision risk assessment, between ATV and space debris, managed in ATV-CC at CNES during phasing to docking and de-orbit phases. First, the methods and results of middle and short term mission analyses are detailed. The effects of the two fragmentation events which occurred shortly before and after the launch (the US ASAT on USA 193 and the natural fragmentation of the Russian satellite COSMOS 2421) have been evaluated using models and data from GRAVES and USSTRATCOM catalogues. The results showed a important impact on the foreseen conjunction rate. Second, the operational procedure of the conjunction management is described. The operational organization within ATV-CC teams and with the international partners is also presented. Then, a statement of the operational conjunction management is done, showing a good consistency level with the predictions. Eventually this led to 3 avoidance events (but only one avoidance maneuver).

  3. Discover Paris with Jules Verne.

    Science.gov (United States)

    Hudson, Anna E.

    1996-01-01

    An approach to teaching French literature that uses a Jules Verne novel published only in 1994 is described. The novel, "Paris in the 20th Century," is the basis for a series of written and oral exercises about the novel, its social and cultural context, the author, and the actual changes that have occurred in Paris in comparison with…

  4. Astronomy and astronomers in Jules Verne's novels

    Science.gov (United States)

    Crovisier, Jacques

    2011-06-01

    Almost all the Voyages Extraordinaires written by Jules Verne refer to astronomy. In some of them, astronomy is even the leading theme. However, Jules Verne was basically not learned in science. His knowledge of astronomy came from contemporaneous popular publications and discussions with specialists among his friends or his family. In this article, I examine, from the text and illustrations of his novels, how astronomy was perceived and conveyed by Jules Verne, with errors and limitations on the one hand, with great respect and enthusiasm on the other hand. This informs us on how astronomy was understood by an ``honnête homme'' in the late 19th century.

  5. Jules Verne's Metaphor of the Iron Cage

    NARCIS (Netherlands)

    Ossewaarde, Marinus R.R.

    2010-01-01

    Max Weber's concept of the iron cage has become a byword in the scholarly world since the publication in 1930 of Talcott Parsons’ translation of The Protestant Ethic and the Spirit of Capitalism. What is less well-known is that Jules Verne had earlier used the iron cage metaphor in Twenty Thousand

  6. Jules Verne's Metaphor of the Iron Cage

    NARCIS (Netherlands)

    Ossewaarde, M.R.R.

    2010-01-01

    Max Weber's concept of the iron cage has become a byword in the scholarly world since the publication in 1930 of Talcott Parsons’ translation of The Protestant Ethic and the Spirit of Capitalism. What is less well-known is that Jules Verne had earlier used the iron cage metaphor in Twenty Thousand L

  7. Jules Verne - a new polishing technique related to FJP

    NARCIS (Netherlands)

    Booij, S.M.; Fähnle, O.W.; Meeder, M.; Wons, T.; Braat, J.J.M.

    2003-01-01

    A variation on the fluid jet polishing (FJP) technique, arbitrarily named Jules Verne (JV), will be described in this article. Jules Verne is a glass processing technique that removes material due to the fact that the tool and the surface are in close contact, and a slurry moves in between the tool

  8. Jules Verne - a new polishing technique related to FJP

    NARCIS (Netherlands)

    Booij, S.M.; Fähnle, O.W.; Meeder, M.; Wons, T.; Braat, J.J.M.

    2003-01-01

    A variation on the fluid jet polishing (FJP) technique, arbitrarily named Jules Verne (JV), will be described in this article. Jules Verne is a glass processing technique that removes material due to the fact that the tool and the surface are in close contact, and a slurry moves in between the tool

  9. Planets, comets and small bodies in Jules Verne's novels

    Science.gov (United States)

    Crovisier, J.

    2011-10-01

    Almost all the Voyages Extraordinaires written by Jules Verne refer to astronomy. In some of them, astronomy is even the leading theme. However, Jules Verne was basically not learned in science. His knowledge of astronomy came from contemporaneous popular publications and discussions with specialists among his friends or his family. In this contribution, I examine, from selected texts and illustrations of his novels, how astronomy — and especially planetary science — was perceived and conveyed by Jules Verne, with errors and limitations on the one hand, with great respect and enthusiasm on the other hand.

  10. Jules Verne Mare Soils as Revealed by Clementine UVVIS Data

    Science.gov (United States)

    Yingst, R. A.; Head, J. W.

    1999-03-01

    To determine the nature of potentially low-Ca pyroxene (noritic) spectra in six South Pole-Aitken basin mare deposits, we undertake a multispectral analysis of a representative of these deposits, that associated with Jules Verne crater.

  11. Sharp and the Jules Verne Launcher

    Science.gov (United States)

    Hunter, John; Cartland, Harry

    1996-03-01

    Lawrence Livermore National Laboratory (LLNL) has built the worlds largest hydrogen gas gun called SHARP, (Super High Altitude Research Project). Originally designed to launch 5 kg to a 450 km altitude, SHARP is configured horizontally at Site 300 in Tracy, California. SHARP is successfully delivering 5 kg scramjets at Mach 9 in aerophysics tests. Some of the results of the scramjet tests are enlightening and are presented insofar as they are relevant to future launches into space. Using a light gas gun to launch payloads into orbit has been analyzed. We look at LEO (Low Earth Orbit), GEO (Geosynchronous Earth Orbit), and LO (Lunar Orbit). We present a conceptual design for a large light gas gun called the Jules Verne Launcher (JVL). The JVL can deliver 3.3 metric tons to a 500 km low earth orbit. We anticipate one launch per day. We present the history of light gas guns, the SHARP design and performance, and the JVL design. Another section is devoted to the vehicle environment and resultant design. Lastly, we present a cost analysis. Our results indicated that the JVL will be able to deliver 1000 metric tons of payload to LEO yearly. The cost will be 5% of the best US rocket delivery cost. This technology will enable the next phase of man's exploration of space.

  12. The Jules Verne island; L'Ile de Jules Verne

    Energy Technology Data Exchange (ETDEWEB)

    Sigfusson, T.I. [Universite d' Islande, Reykjavik, et Icelandic New Energy, Reykjavik (Iceland)

    2004-11-01

    During a thousand of years since its colonization by the Vikings in 874, Iceland has been practically an energy-less country. The French imaginative writer Jules Verne published his novel 'the mystery island' in 1874, i.e. exactly at the time of the first millennium of existence of the Icelandic people. In his book, J. Verne has imagined an island where the energy source was hydrogen produced by water electrolysis. Iceland is progressively building an hydrogen-based society like the one of J. Verne's dream. This article describes the path to follow to reach such a society: energy situation of Iceland today, history of energy conversion technologies, environmental impacts, feasibility of an hydrogen-based economy, 50 years transition era between petroleum product and hydrogen uses in the transportation sector, ECTOS (ecological city transport system) project, cooperation with other European countries (in particular France), hydrogen production and storage technologies, research on metal hydrides, teaching and information dissemination program. (J.S.)

  13. Army After Next, Airland Battle 2000, Futuristic Concepts or Jules Verne?

    Science.gov (United States)

    1998-04-14

    service or government agency. STRATEGY RESEARCH PROJECT ARMY AFTER NEXT, AIRLAND BATTLE 2000, FUTURISTIC CONCEPTS OR JULES VERNE ? BY...AIRLAND BATTLE 2000, FUTURISTIC CONCEPTS OR JULES VERNE ? by LTC Francis G. Mahon Dr. Douglas V. Johnson Project Advisor Colonel Ronald Ouellette...Battle 2000, Futuristic Concepts or Jules Verne ? FORMAT: Strategy Research Project DATE: 14 April 1998 PAGES: 67 CLASSIFICATION

  14. Jules Verne: a new polishing technique related to FJP

    Science.gov (United States)

    Booij, Silvia M.; Faehnle, Oliver W.; Meeder, Mark; Wons, Torsten; Braat, Joseph J. M.

    2004-01-01

    A variation on the fluid jet polishing (FJP) technique, arbitrarily named Jules Verne (JV), will be described in this article. Jules Verne is a glass processing technique that removes material due to the fact that the tool and the surface are in close contact, and a slurry moves in between the tool and the surface. This approach has both advantages and disadvantages with respect to the original FJP modus: it enables a feed-controlled machining process, but deeper lying areas are harder to reach. A simulation model will be presented that predicts the flow of the slurry in the Jules Verne setup, which is followed by the computation of the trajectories of the particles in the flow. Furthermore, experimental data will be reported demonstrating the feasibility of the JV idea. A model will also be presented simulating the interaction between the surface and the impinging abrasives at a microscopic level, enabling the prediction of the final surface roughness.

  15. In Jules Verne's Footsteps: Seismology in the source

    Science.gov (United States)

    Ellsworth, Bill; Ito, Hisao; Malin, Peter; Abercrombie, Rachel

    When Professor Otto Lidenbrock led his little band to the center of the Earth in Jules Verne's 1864 classic novel, the intrepid adventurers needed little more than practical 19th century clothes to provide them with comfort and protection. How different the science of earthquakes would be if conditions in the Earth were really so friendly to the would-be observer. Even the operation of seismic sensors at the relatively modest depth of 2-3 km, roughly the depth of the shallowest crustal earthquakes, requires careful precautions against the effects of unstable materials, temperature, pressure, and water for successful long-term observations to be made. Indeed, the handful of successful deep borehole experiments that have been conducted to date have depended on simple sensors with limited bandwidth and dynamic range, and have yielded data that were not ideally suited to investigating the details of the earthquake source.

  16. Jules Verne Voyager: A Web Interactive Tool for Comparative Planetology

    Science.gov (United States)

    Estey, L.; Pappalardo, R.; Meertens, C.

    2004-12-01

    A Web interactive map tool called "Jules Verne Voyager" was originally developed in 1999 by UNAVCO and continues to evolve. The Voyager tool can easily be used for comparative planetology studies by grades 8-14. Thematic mapping datasets, now totaling about 70 Gb, can be accessed by the tool and include global-scale maps of the inner solar system planets and moons, plus Jupiter and the Galilean moons. The map images are viewed on a Web browser created on demand by the server system. On the client-side, only a Java-enabled browser is required, and the Voyager Java applet runs well with common browsers like Netscape, Mozilla, Opera, and Internet Explorer. The applet sends a key-value pair URL to the http://jules.unavco.org server which queues incoming requests and sends them to a bank of computers dedicated to map image creation. The engine for map image creation makes use of the "Generic Mapping Tools" (GMT) software of Paul Wessel and Walter Smith, followed by image conversion of the GMT-created PostScript to GIF for raster image export and display back on the client browser. Because of the GMT-based engine on the server system, the student user can easily create the same type of images from real planetary data that researchers create. The tool also gives a student the ability to switch background datasets and overlay certain other thematic datasets, thus providing a minimal GIS capability. To our knowledge, the map tool has not yet formally been used in a 8-14 classroom environment, though informal use by students and teachers in these grades suggest that it would be well received. The server system is currently capable of handing a moderate level of requests that would result from classroom use; for example, as a system benchmark, over 800 Voyager images were created and served in about an hour during a DLESE 2003 annual meeting workshop. The Voyager map tool is being used by instructors in earth science and comparative planetology as a means to create customized

  17. POSITIVISM, INDUSTRIAL REVOLUTION AND URBANISM - UTOPIA AND REALITY IN THE JULES VERNE'S NOVEL "THE BEGUM'S FORTUNE"

    Directory of Open Access Journals (Sweden)

    Daniel H. Valsecchi

    2009-01-01

    Full Text Available The aim of this article is to analyze negative consequences (social, political, psychological and so forth of utopian projects, which crippled society and people by negation of reality and at the same time oblige them to accept these plans. In order to do this we analyze characteristics of two constructions which are thoroughly depicted by Jules Verne: an Arms Fabric (Stahlstadt and a city which was mathematically built (France Ville. Furthermore there are reflections about positivism - i.e. the ground of these projects.

  18. Jules Verne Voyager, Jr: An Interactive Map Tool for Teaching Plate Tectonics

    Science.gov (United States)

    Hamburger, M. W.; Meertens, C. M.

    2010-12-01

    We present an interactive, web-based map utility that can make new geological and geophysical results accessible to a large number and variety of users. The tool provides a user-friendly interface that allows users to access a variety of maps, satellite images, and geophysical data at a range of spatial scales. The map tool, dubbed 'Jules Verne Voyager, Jr.', allows users to interactively create maps of a variety of study areas around the world. The utility was developed in collaboration with the UNAVCO Consortium for study of global-scale tectonic processes. Users can choose from a variety of base maps (including "Face of the Earth" and "Earth at Night" satellite imagery mosaics, global topography, geoid, sea-floor age, strain rate and seismic hazard maps, and others), add a number of geographic and geophysical overlays (coastlines, political boundaries, rivers and lakes, earthquake and volcano locations, stress axes, etc.), and then superimpose both observed and model velocity vectors representing a compilation of 2933 GPS geodetic measurements from around the world. A remarkable characteristic of the geodetic compilation is that users can select from some 21 plates' frames of reference, allowing a visual representation of both 'absolute' plate motion (in a no-net rotation reference frame) and relative motion along all of the world's plate boundaries. The tool allows users to zoom among at least three map scales. The map tool can be viewed at http://jules.unavco.org/VoyagerJr/Earth. A more detailed version of the map utility, developed in conjunction with the EarthScope initiative, focuses on North America geodynamics, and provides more detailed geophysical and geographic information for the United States, Canada, and Mexico. The ‘EarthScope Voyager’ can be accessed at http://jules.unavco.org/VoyagerJr/EarthScope. Because the system uses pre-constructed gif images and overlays, the system can rapidly create and display maps to a large number of users

  19. [Citation errors: Uplavici (for Hlava) and William the Silent (for Jules Verne and Mignet)].

    Science.gov (United States)

    Lienhart, A

    2011-05-01

    A certain 'O Uplavici' was cited for more than fifty years, although he had never existed. This error probably came from a misinterpretation of the Czech language, in which the real author's name--Hlava--can mean 'Title'. It was finally recognized, which was not the case for the author of the sentence: 'I have no need of hope to take action, nor of success to persevere', it is still regularly attributed in France to William I, Prince of Orange, called the Silent. It is a mistake, and no serious reference certifies that an historical figure would have pronounced this sentence. It was written by the historian Mignet in 1841, to describe the character of William III, Prince of Orange and King of England. It was then used in 1875 by Jules Verne, to describe a character in 'The Mysterious Island'. Copyright © 2011. Published by Elsevier SAS.

  20. Vamos ao Brasil com Jules Verne?: processos editoriais e civilização nas Voyages Extraordinaires

    Directory of Open Access Journals (Sweden)

    Andréa Borges Leão

    2012-12-01

    Full Text Available No século XIX, uma rede de conhecimentos sobre as diferenças culturais dos povos americanos marcou a edição destinada à instrução e diversão da juventude francesa. Uma das 62 Voyages Extraordinaires de Jules Verne, publicadas por Pierre-Jules Hetzel, é ambientada entre o Peru e o Brasil: La Jangada, huit cents lieues sur l'Amazone (1881. Na produção de literatura juvenil que se desenvolve e expande no comércio transatlântico da livraria francesa, sobressai uma psicogênese do Brasil. Por esse ângulo, a via de análise aberta pelo sociólogo Norbert Elias ajudou a enfrentar o problema das emoções humanas, no romance de viagem, e a conceituar a atividade mimética no livro de ciência e recreação.In the 19th century, a net of knowledge about cultural differences of the populations of Americas imprint the edition assign to instruction and entertainment of the young French people. One of the 62 Voyages Extraordinaires of Jules Verne, published by Pierre-Jules Hetzel, is set between Peru and Brazil: La Jangada, huit cents lieues sur l'Amazone (Eight Hundred Leagues on the Amazon - 1881. Around the juvenile production that grows and expands in the transatlantic trade of the French bookstore, a psychogenesis of Brazil shines through. By this angle, the analytic way opened by the sociologist Norbert Elias helps to face the problem of the human emotions in the travel novel and also helps to consider the mimetic activity in the book of science and entertainment.

  1. D'Elisée Reclus à Jules Verne. Aux origines de la géographie dans les Voyages Extraordinaires.

    OpenAIRE

    Dupuy, Lionel

    2006-01-01

    Les Voyages Extraordinaires de Jules Verne témoignent de nombreux emprunts aux ouvrages du géographe français Elisée Reclus, au premier rang desquels figure sa monumentale Nouvelle Géographie Universelle. Il est intéressant de remarquer que les références directes a Elisée Reclus dans les romans de Jules Verne datent toutes d'après 1885, un tournant majeur dans la production vernienne.

  2. Analysis of Media Stereotypes of the Russian Image in Media Studies in the Student Audience (example: the screen versions of Jules Verne's Novel “Michael Strogoff”

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2014-09-01

    Full Text Available As a result of the analysis students come to the conclusion that the screen adaptations of Jules Verne's novel ''Michael Strogoff'' create, though an oversimplified and adapted to western stereotypes of perception, but a positive image of Russia – as a stronghold of European values at the Asian frontiers, a country with a severe climate, boundless Siberian spacious areas, manly and patriotic warriors, a wise monarchy. At the same time, both Jules Verne's novel and its screen adaptations contain clear-cut western pragmatism – the confidence that if a man has a proper will he can rule his destiny.

  3. Jules Verne, le Québec et le Canada. Variations sur la géographie et l'écologie humaine dans trois romans canadiens de Jules Verne.

    OpenAIRE

    Dupuy, Lionel

    2009-01-01

    La géographie est au cœur des récits verniens, elle en est la pierre angulaire. Nous avions à ce titre présenté dans un article précédent comment la géographie, en particulier dans les romans de Jules Verne, peut être abordée également dans sa dimension imaginaire, symbolique, mystérieuse. Nous aimerions ainsi, dans ce nouvel article, souligner comment cette dernière sert aussi de base à l'élaboration de ce que nous pouvons appeler aujourd'hui une écologie humaine des Voyages Extraordinaires....

  4. La géographie de Jules Verne et ses cartes dans L’île mystérieuse

    Directory of Open Access Journals (Sweden)

    Jacky Fontanabona

    2010-05-01

    Full Text Available Destinés à la jeunesse, les Voyages extraordinaires ont une vocation récréative mais aussi éducative. Romancier, Jules Verne veut aussi contribuer à la diffusion d'une géographie de son temps, descriptive, encyclopédique, de plain-pied dans une réalité constituée de «faits avérés». Dans L’île mystérieuse, il subvertit cette dernière règle en narrant la colonisation d’un territoire fictif par des Robinsons. Articulant carte, images et texte littéraire, l'édition illustrée devient alors un système d’expression qui joue du diptyque véracité/véridicité pour inventer une chimère géographique.

  5. Vamos ao Brasil com Jules Verne?: processos editoriais e civilização nas Voyages Extraordinaires

    Directory of Open Access Journals (Sweden)

    Andréa Borges Leão

    2012-12-01

    Full Text Available No século XIX, uma rede de conhecimentos sobre as diferenças culturais dos povos americanos marcou a edição destinada à instrução e diversão da juventude francesa. Uma das 62 Voyages Extraordinaires de Jules Verne, publicadas por Pierre-Jules Hetzel, é ambientada entre o Peru e o Brasil: La Jangada, huit cents lieues sur l'Amazone (1881. Na produção de literatura juvenil que se desenvolve e expande no comércio transatlântico da livraria francesa, sobressai uma psicogênese do Brasil. Por esse ângulo, a via de análise aberta pelo sociólogo Norbert Elias ajudou a enfrentar o problema das emoções humanas, no romance de viagem, e a conceituar a atividade mimética no livro de ciência e recreação.

  6. Jules Verne, Le Superbe Orénoque et la géophagie. L'intertextualité au service de l'exotisme géographique.

    OpenAIRE

    Dupuy, Lionel

    2009-01-01

    L'exégèse de l'œuvre de Jules Verne ouvre parfois la voie à des interprétations très inattendues. Tel est ainsi l'exemple de la géophagie que l'auteur évoque dans quelques-uns de ses romans, et plus particulièrement dans Le Superbe Orénoque (1898). Si pour certains auteurs Jules Verne fait directement écho ici à ses propres ennuis gastriques, nous voudrions cependant rappeler les sources qu'il a utilisées pour écrire son roman. Sans renier pour autant l'interprétation qui est proposée par ces...

  7. Water Will Be the Coal of the Future—The Untamed Dream of Jules Verne for a Solar Fuel

    Directory of Open Access Journals (Sweden)

    Vladimir K. Ryabchuk

    2016-11-01

    Full Text Available This article evokes the futuristic visions of two giants, one a writer, Jules Verne, who foresaw water as the coal of the future, and the other a scientist, Giacomo Ciamician, who foresaw the utilization of solar energy as an energy source with which to drive photochemical and photocatalytic reactions for the betterment of mankind. Specifically, we examine briefly the early work of the 1960s and 1970s on the photosplitting of free water and water adsorbed on solid supports, based mostly on metal oxides, from which both hydrogen and oxygen evolve in the expected stoichiometric ratio of 2 to 1. The two oil crises of the 1970s (1973 and 1979 spurred the interest of researchers from various disciplines (photochemistry, photo-catalysis and photoelectrochemistry in search of a Holy Grail photocatalyst, process, or strategy to achieve efficient water splitting so as to provide an energy source alternative to fossil fuels. Some approaches to the photosplitting of water adsorbed on solid insulators (high bandgap materials; Ebg ≥ 5 eV and semiconductor photocatalysts (metal oxides are described from which we deduce that metal oxides with bandgap energies around 5 eV (e.g., ZrO2 are more promising materials to achieve significant water splitting on the basis of quantum yields than narrower bandgap photocatalysts (e.g., TiO2; Ebg ≈ 3.0–3.2 eV, which tend to be relatively inactive by comparison. Although proof of concept of the photosplitting of water has been demonstrated repeatedly in the last four decades, much remains to be done to find the Holy Grail photocatalyst and/or strategy to achieve significant yields of hydrogen.

  8. Water Will Be the Coal of the Future-The Untamed Dream of Jules Verne for a Solar Fuel.

    Science.gov (United States)

    Ryabchuk, Vladimir K; Kuznetsov, Vyacheslav N; Emeline, Alexei V; Artem'ev, Yurii M; Kataeva, Galina V; Horikoshi, Satoshi; Serpone, Nick

    2016-11-29

    This article evokes the futuristic visions of two giants, one a writer, Jules Verne, who foresaw water as the coal of the future, and the other a scientist, Giacomo Ciamician, who foresaw the utilization of solar energy as an energy source with which to drive photochemical and photocatalytic reactions for the betterment of mankind. Specifically, we examine briefly the early work of the 1960s and 1970s on the photosplitting of free water and water adsorbed on solid supports, based mostly on metal oxides, from which both hydrogen and oxygen evolve in the expected stoichiometric ratio of 2 to 1. The two oil crises of the 1970s (1973 and 1979) spurred the interest of researchers from various disciplines (photochemistry, photo-catalysis and photoelectrochemistry) in search of a Holy Grail photocatalyst, process, or strategy to achieve efficient water splitting so as to provide an energy source alternative to fossil fuels. Some approaches to the photosplitting of water adsorbed on solid insulators (high bandgap materials; Ebg ≥ 5 eV) and semiconductor photocatalysts (metal oxides) are described from which we deduce that metal oxides with bandgap energies around 5 eV (e.g., ZrO₂) are more promising materials to achieve significant water splitting on the basis of quantum yields than narrower bandgap photocatalysts (e.g., TiO₂; Ebg ≈ 3.0-3.2 eV), which tend to be relatively inactive by comparison. Although proof of concept of the photosplitting of water has been demonstrated repeatedly in the last four decades, much remains to be done to find the Holy Grail photocatalyst and/or strategy to achieve significant yields of hydrogen.

  9. La recepció de l'obra de Jules Verne pels lectors de diferents èpoques : Anàlisi de traduccions i adaptacions en català, castellà i anglès

    OpenAIRE

    Capdevila Vinaja, Marta

    2015-01-01

    Anàlisi de l'obra de Jules Verne des del punt de vista educatiu. Exposició dels seu valor educatiu en el camp de la ciència, la geografia i la història, així com també dels seus valors morals. Contradiccions entre la intenció educativa de les seves traduccions i adaptacions per a joves lectors actuals i el xoc moral que pot provocar el racisme, l'etnocentrisme i el masclisme del segle XIX, present implícitament i explícit a totes les obres de Jules Verne. Análisis de la obra de Julio Verne...

  10. ATV ahoy - final preparations for the first flight of Europe's Space Ferry

    Science.gov (United States)

    Ellwood, John; Clervoy, Jean-François; Castel, Frederic

    2007-05-01

    Jules Verne, the first of five Automated Transfer Vehicles (ATVs), stands on the brink of flight. Its inaugural mission, set for the second half of 2007, will conclude an extensive 3-year test campaign. During the coming crucial months, the programme faces three key objectives: prepare for flight, finetune the interfaces with the International Space Station and the ISS partners, and ready Ariane-5 for launching its largest payload to date.

  11. Post-Flight Analysis of Dynamic Data Acquired During the ATV-2 Johannes Kepler Launch

    Science.gov (United States)

    Meitzner, R.; Abdoly, K.; Newerla, A.

    2012-07-01

    An in-flight data acquisition system called TeleMesure Autonome (TMA) has been implemented on ATV-1 Jules Verne (launched in March 2008) and ATV-2 Johannes Kepler (launched in February 2011). The TMA served the main objective to measure dynamic responses on the ATV spacecraft for comparison with coupled load analysis predictions and to verify that the ATV mechanical flight environment has been sufficiently covered by the respective ATV design specifications. The acquired flight data included low frequency sinusoidal, random vibration and shock measurements. Whereas the TMA on ATV-1 Jules Verne failed to properly work after 17 seconds after liftoff the improved TMA on ATV-2 Johannes Kepler performed its tasks successfully for all flight phases. The flight data have been subsequently evaluated by the ATV prime contractor Astrium. As first step of the performed analyses a correction of the acquired data was necessary to remove any artificial content (spikes, mean truncation, offset correction) followed by a visual inspection of the corrected data to ensure data quality. Then standard post processing methods were applied to the data consisting of generating equivalent sinusoidal responses and transfer functions for the low frequency data, power spectral densities for the random data and shock responses for the high frequency shock data. Although it was noted that the quality of the data was limited by the available transmission bandwidth and the amplitude resolution of the data acquisition system the implementation of the TMA on ATV-2 Johannes Kepler has nevertheless turned out successful and valuable data have been acquired for all relevant flight phases.

  12. En malstrøm til begjær. Moskenesstraumen som myte og metafor hos Petter Dass, Edgar Allan Poe og Jules Verne

    Directory of Open Access Journals (Sweden)

    Even Arntzen

    2003-08-01

    Full Text Available Gjennom uminnelige tider har mennesket vært fascinert av havet. I en rekke skapelsesmyter fremstår gjerne havet som en positiv størrelse, en pulserende og livgivende urtidsstrøm. Men ved siden av å være en raus kilde til liv, er havet også nært forbundet med undergang og død,forlis og drukning. Få havstykker har som den beryktede Moskenesstraumen fått denne havets dobbelthet knyttet til seg - på den ene siden verdens største barselseng, på den annen side dødens grusomme svelg. Kanskje med unntak av Bermuda-trianglet i Sargassohavet, stedet hvor skip, og etter hvert også fly, angivelig skal ha forsvunnet sporløst i årevis, er det neppe noe havområde i verden som opp gjennom århundrene er blitt beskrevet og illustrert i tilsvarende grad som Moskenesstraumen. I denne artikkelen skal jeg rette fokus mot tre av de mange som, på høyst forskjellig vis, har latt seg fascinere og inspirere av Moskenesstraumen, nemlig Petter Dass, Edgar Allan Poeog Jules Verne.

  13. Assessment of the ATV-1 Re-Entry Observation Campaign for Future Re-Entry Missions

    Science.gov (United States)

    Lips, T.; Lohle, S.; Marynowsky, T.; Rees, D.; Stenbeak-Nielsen, H. C.; Beks, M. L.; Hatton, J.

    2010-09-01

    This paper summarizes the midterm results of the currently ongoing ESA study “Assessment of the ATV-1 Reentry Observation Campaign for Future Re-entry Missions”. The primary objective of this study is to investigate the data obtained during a joint ESA/NASA airborne observation campaign of the destructive re-entry of ATV-1 Jules Verne which occurred on September 29, 2008. The presented results are focused on spectroscopic fragment characterization(material identification), frame-by-frame fragment tracking(manual and automatic) for various video recordings, 3D triangulation of the tracked fragments, and fragment propagation until complete demise or ground impact, including the actual size and location of the ATV-1 debris footprint. Fragment propagation analyses comprise also the derivation of aerodynamic fragment properties and potential delta velocities. These parameters are of high importance for the re-entry safety analysis for ATV-2 Johannes Kepler.

  14. Airborne re-entry observation experiment SLIT: UV spectroscopy during STARDUST and ATV1 re-entry

    Science.gov (United States)

    Löhle, Stefan; Wernitz, Ricarda; Herdrich, Georg; Fertig, Markus; Röser, Hans-Peter; Ritter, Heiko

    2011-09-01

    Emission spectra during re-entry have been measured in 2006 for the STARDUST capsule and in 2008 for the ATV1 "Jules Verne" re-entry. This paper summarizes the approach to design the airborne UV spectroscopic setup and its modifications with respect to the missions. For the STARDUST mission, results of data analysis of data presented in 2008 are given while for the ATV1 observation first spectra of the main disruption are exemplary presented. The surface radiation during the STARDUST re-entry is used to estimate convective and radiative heat flux using different analytical models. A first look at the spectroscopic footprint of ATV1 shows that during the first explosive event, a severe break-up of the main ATV1 structure occurs. However, a correlation with an explosion of fuel could not be observed.

  15. Review and Assessment of ATV Observation Data for Events Characterization

    Science.gov (United States)

    Mazoue, Franck; Beck, James; Reynier, Philippe

    2011-02-01

    For investigating ATV re-entry, observation airborne campaigns have been carried out at the end of the mission to ISS of Jules Verne ATV. The observations of re-entry have highlighted that the in-flight scenario was quite different to the nominal one, since two explosions occurred during the flight. In this paper, the data gathered during the observations have been analysed in the perspective of the explosion analysis. The potential explosive elements present on board have been studied and the explosion products identified. To identify the possible scenario that led to the vehicle explosion the list of explosion products has been compared with the radiators put in evidence in the spectra obtained by spectroscopy during the flight. Finally, the most reliable scenario has been identified and the power available for explosion evaluated. This shows that non negligible delta V could have been produced by the explosion.

  16. Long Range Validation of ATV-ISS Rendez-Vous and Docking Using EPOSx

    Science.gov (United States)

    Schreutelkamp, E.

    2008-08-01

    On April 3 at 16:40, Jules Verne, the first of a series at least 5 Automated Transfer Vehicles (ATV) docked successfully and safely at the International Space Station (ISS). This paper describes the very large test facility that was needed to perform the validation of the Rendez Vous and Docking (RVD) of this safety critical process. It describes the facility in detail as well as the Hardware and Software mechanisms needed to perform these tests at such a large scale while still meeting the high accuracy and safety requirements for the docking procedures. Furthermore it describes the environmental conditions needed to be such that the real flight hardware could be used without risk. The paper also tries to answer the question if designing such a large test facility so late into the ATV development process was a wise decision and if all that effort paid off in the end.

  17. ATV Cargo Integration Safety Certification Process

    Science.gov (United States)

    Garbellini, L.; Heimann, T. J.

    2005-12-01

    A large number of manned modules are being progressively launched to the International Space Station (ISS) and integrated on-orbit, required to be operated and maintained over long on-orbit stay time, supported by periodical servicing and supply.The European Space Agency (ESA), together with its several industrial aerospace contractors such as Alcatel Alenia Space, is deeply involved in development of space systems hardware, in planning and execution of mission operations, logistics and supply to ISS of consumables, payloads, scientific experiments, orbital replacement units up to station modules and infrastructures, as needed by the ISS utilization cycles. In this frame safety plays a significant role to assure that the safety of the systems is preserved throughout the ISS exploitation phase. This paper summarizes methods and requirements for the safety certification process being implemented to dry cargo integration and accommodation in Jules Verne, the 1st flight of the Automated Transfer Vehicle (ATV), one of the major ESA contributions to the utilization of ISS.

  18. Alexis Carrel: Jules Verne of cardiovascular surgery.

    Science.gov (United States)

    Friedman, S G

    1988-03-01

    There is in every field one individual who stands apart as a great thinker, leader, or teacher. In the field of cardiovascular surgery, Alexis Carrel was each of these. Proof of this lies in the fact that daily, the modern cardiovascular surgeon is likely to use a concept or technique first developed by Carrel. During the 75th anniversary year of Carrel's receipt of the Nobel Prize, the life and work of this great innovator should be remembered.

  19. Planeta Verne. La vuelta al mundo en ochenta libros

    OpenAIRE

    Martínez de Pisón, Eduardo

    2015-01-01

    Eduardo Martínez de Pisón se centra en la faceta geográfica de Julio Verne a través de un libro suyo titulado la “Tierra de Jules Verne. Geografía y aventura”, en donde se realiza una introducción a la obra geográfica del escritor. Para ello, el autor analiza la producción literaria de Verne buscando elementos geográficos en los pasajes de ficción y se estudia en relación a la abundante e influyente base geográfica de sus relatos. También se analiza el valor manifiestamente pedagógico de la o...

  20. Planeta Verne. La vuelta al mundo en ochenta libros

    OpenAIRE

    Martínez de Pisón, Eduardo

    2015-01-01

    Eduardo Martínez de Pisón se centra en la faceta geográfica de Julio Verne a través de un libro suyo titulado la “Tierra de Jules Verne. Geografía y aventura”, en donde se realiza una introducción a la obra geográfica del escritor. Para ello, el autor analiza la producción literaria de Verne buscando elementos geográficos en los pasajes de ficción y se estudia en relación a la abundante e influyente base geográfica de sus relatos. También se analiza el valor manifiestamente pedagógico de la o...

  1. Analysis Of The ATV1 Re-Entry Using Near-UV Spectroscopic Data From The ESA/NASA Multi-Instrument Aircraft Observation Campaign

    Science.gov (United States)

    Lohle, Stefan; Marynowski, Thomas; Knapp, Andreas; Wernitz, Ricarda; Lips, Tobias

    2011-05-01

    The first Automated Transfer Vehicle (ATV1) named Jules Verne was launched in March 2009 to carry over seven tons of experiments, fuel, water, food and other supplies to the International Space Station (ISS) orbiting at about 350 km. Attached to the ISS, it served as an extension to the space station, giving extra space for the six astronauts and cosmonauts who will ultimately form the permanent ISS Crew. On September 29, 2009, a controlled de-orbit maneuver lead the spacecraft to enter the Earth's atmosphere over the south pacific ocean. The following destructive re-entry was observed by two aircraft equipped with a wide variety of imaging and spectroscopic instruments. In this paper, we present quantitative results from the near-UV spectroscopic measurements acquired aboard an experimental DC-8 aircraft operated by NASA. The wavelength range of observation allows a determination of temperatures from radiation and the investigation of atomic radiation with respect to the identification of the destructive process. Furthermore, the excitation temperatures of chromium give an insight into the explosive events occurring during re-entry. Analysing the continuum of the measured spectra, the Planck radiation temperature is fitted to the data. These temperatures indicate that most of the radiating parts are titanium alloys, i.e. the outer structure of ATV1. All results within this paper are compared to a simulated break-up scenario and related to basic results from other experimenters which allows drawing an overall scenario for this destructive re-entry.

  2. París en el siglo XX según Julio Verne

    OpenAIRE

    Diego, Rosa de

    1995-01-01

    L'objet de cet article est l'analyse du roman de Jules Verne "Paris au XX siècle", écrit en 1863 et inédit jusqu'a 1994. Il s'agit d'un roman d'imagination scientifique parce qu'il décrit et anticipe, avec une exactitude surprenante, comment sera Paris pendant la deuxieme moitié du XX siècle, sous un point de vue urbanistique, technologique, économique et social. Jules Verne apparait également comme un écrivain philosophe, avec une vision péssimiste du progrès de la civilisation et de la soli...

  3. París en el siglo XX según Julio Verne

    OpenAIRE

    Diego, Rosa de

    1995-01-01

    L'objet de cet article est l'analyse du roman de Jules Verne "Paris au XX siècle", écrit en 1863 et inédit jusqu'a 1994. Il s'agit d'un roman d'imagination scientifique parce qu'il décrit et anticipe, avec une exactitude surprenante, comment sera Paris pendant la deuxieme moitié du XX siècle, sous un point de vue urbanistique, technologique, économique et social. Jules Verne apparait également comme un écrivain philosophe, avec une vision péssimiste du progrès de la civilisation et de la soli...

  4. Guidance and Navigation Software Architecture Design for the Autonomous Multi-Agent Physically Interacting Spacecraft (AMPHIS) Test Bed

    Science.gov (United States)

    2006-12-01

    class, the Jules Verne successfully completed the autonomous rendezvous and docking system in Europe’s largest ship hull test facility in September...replicate the 2007 Jules Verne mission. http://www.esa.int/SPECIALS/ATV/SEMWCEKKKSE_0.html. 23. Banke, K., Air Force XSS-10 Micro-Satellite Mission a

  5. JULES-ANTOINE REGNAULD

    Directory of Open Access Journals (Sweden)

    Jaime Wisniak

    2015-01-01

    Full Text Available Jules - Antoine Regnauld (1822 - 1895, médico y farmacéutico francés q ue realizó investigaciones sobre los alcaloides midriáticos (como la atropina, fenómenos electroquímicos, fuerza electromotriz, amalgamas, propiedades de mezclado en disoluciones salinas, fisiología, electrofisiología, fluorescencia de órganos vivos, quím ica médica, anestesia y fenómenos de visión. Como resultado de ellos inventó un nuevo procedimiento para medir la fuerza electromotriz (método de oposición, y desarrolló una explicación de la influencia de la electricidad sobre los músculos y la visión bi nocular.

  6. L’Asie mystérieuse : premier numéro du Bulletin du Club Verne

    Directory of Open Access Journals (Sweden)

    Alain Chiron

    2012-02-01

    Full Text Available Depuis 2007 l’Association des Amis du Roman populaire a son siège et son centre de documentation à Vignacourt près d’Amiens. Si la revue Le Rocambole qu’elle produit perdure, cette association a souhaité replacer dans des objectifs de vulgarisation l’œuvre de Jules Verne dans le contexte de production de romans populaires pour la période allant des débuts du XIXe siècle à la Grande Guerre. D’où la création du nouveau périodique le Bulletin du Club Verne. Il est nécessaire de distinguer ce der...

  7. Un viaje al interior de la lectura con Julio Verne

    Directory of Open Access Journals (Sweden)

    Ma. Begoña Carretero Gómez

    2008-01-01

    Full Text Available Este trabajo se ha centrado en la lectura de textos de ciencia ficción en las clases de ciencias. El objetivo más importante de esta experiencia ha sido conseguir que los alumnos desarrollen la capacidad de relacionar conceptos que aparecen en la lectura con los conocimientos adquiridos previamente en clase. Como bien dice Loscertales y Núñez (1997 los alumnos de nuestro sistema educativo son los que configuran el trabajo del profesor, el cual deberá poner en práctica todos los recursos a su alcance para adecuar el proceso de enseñanza-aprendizaje a los intereses, necesidades, y características del alumnado. Por ello la idea de acudir a la lectura de textos de ciencia ficción sería una buena forma de hacer este proceso más atractivo.Es muy importante acercar la ciencia y hacerla más accesible. La ciencia ficción ayuda a fomentar el interés por las ciencias estimulando la curiosidad del alumnado, por lo que utilizarla en las clases Biología ha sido una buena estrategia para conseguir aproximar la ciencia y mejorar la capacidad lectora del alumnado. Para llevarla a cabo se ha elegido la novela “Viaje al centro de la Tierra” de Jules Verne.

  8. Un viaje al interior de la lectura con Julio Verne

    Directory of Open Access Journals (Sweden)

    Carretero Gómez, Mª.B

    2008-09-01

    Full Text Available Este trabajo se ha centrado en la lectura de textos de ciencia ficción en las clases de ciencias. El objetivo más importante de esta experiencia ha sido conseguir que los alumnos desarrollen la capacidad de relacionar conceptos que aparecen en la lectura con los conocimientos adquiridos previamente en clase. Como bien dice Loscertales y Núñez (1997 los alumnos de nuestro sistema educativo son los que configuran el trabajo del profesor, el cual deberá poner en práctica todos los recursos a su alcance para adecuar el proceso de enseñanza-aprendizaje a los intereses, necesidades, y características del alumnado. Por ello la idea de acudir a la lectura de textos de ciencia ficción sería una buena forma de hacer este proceso más atractivo. Es muy importante acercar la ciencia y hacerla más accesible. La ciencia ficción ayuda a fomentar el interés por las ciencias estimulando la curiosidad del alumnado, por lo que utilizarla en las clases Biología ha sido una buena estrategia para conseguir aproximar la ciencia y mejorar la capacidad lectora del alumnado. Para llevarla a cabo se ha elegido la novela “Viaje al centro de la Tierra” de Jules Verne.

  9. Jules Verne Network: Extending and federating efforts to promote Earth sciences

    Science.gov (United States)

    Rosmorduc, V.; Bonnefond, P.; Stewart, R.

    2003-04-01

    Earth sciences are a key element of the many issues concerning the environment, natural resource management and the place of humankind on Earth today. Earth science disciplines have taken a giant leap with the emergence of space-based observation techniques, but the benefits of advances achieved have not always been felt outside specialist circles. Our aim is to develop, encourage and raise awareness of these achievements, through outreach actions and educational programs, by informing persons likely to use and exploit results, as well as decision-makers and elected representatives, and by communicating to scientists working in related disciplines. We propose, within an international framework, to bring together scientists, engineers, teachers and science communicators to raise awareness among a broad spectrum of audiences of the current state of Earth science knowledge, especially what we have learned through space-based observations. By Earth sciences we mean all sciences studying the lithosphere, oceans, atmosphere, cryosphere, biosphere and other components of our planet and the way they interact.

  10. Jules Verne's "Around the World in Eighty Days": Helping Teach the National Geography Standards

    Science.gov (United States)

    Donaldson, Daniel P.; Kuhlke, Olaf

    2009-01-01

    Consistent with developments in American education pedagogy, geography educators have made great strides exploring a wide range of high- and low-tech methods for teaching and learning geographic concepts. This article draws on a qualitative analysis of essays in which college students discuss tenets of the National Geography Standards in the…

  11. Jules Horowitz Reactor, basic design

    Energy Technology Data Exchange (ETDEWEB)

    Bergamaschi, Y.; Bouilloux, Y.; Chantoin, P.; Guigon, B.; Bravo, X.; Germain, C.; Rommens, M.; Tremodeux, P

    2003-07-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it. It has the ambition to provide the necessary nuclear data and maintain a fission research capacity in Europe after 2010. This capacity should be service-oriented. It will be established in Cadarache. The Jules Horowitz reactor will also: - represent a significant step in term of performances and experimental capabilities, - be designed with a high flexibility, in order to satisfy the current demand from European industry, research and be able to accommodate future requirements, - reach a high level of safety, according to the best current practice. This paper will present the main functionalities and the design options resulting from the 'preliminary design' studies. (authors)

  12. Laverne (Vern) C. Johnson (1925-2016).

    Science.gov (United States)

    Nelson, Paul

    2017-01-01

    Presents an obituary for Laverne (Vern) C. Johnson, who died at his home in La Mesa, California on October 1, 2016. Vern was a clinical psychologist who for two decades focused on a major program of research on sleep and biological rhythms, with particular emphasis on the relation of sleep loss and recovery to human performance, a matter of particular relevance to military service operations, in which variable work shift schedules and sustained performance over extended time periods are common. His publications attest to a core value he advanced throughout his career, namely, that scientific research at its best is a collaborative, team endeavor. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  13. ATVs: motorized toys or vehicles for children?

    Science.gov (United States)

    Yanchar, N L; Kennedy, R; Russell, C

    2006-02-01

    To compare the nature of injuries from all-terrain vehicles (ATVs) to those from bicycling, dirtbikes/motocross, and motor vehicle crashes. Data on injuries from the mechanisms outlined above were obtained through CHIRPP (the Canadian Hospitals Injury Reporting and Prevention Program) and hospital records. A Canadian tertiary pediatric center. Cases presenting to the emergency department over a 10 year period. Comparison between demographics, mechanisms and natures of injuries sustained, disposition from the emergency department, and lengths of hospital stay. Contrary to bicycling, ATV related injuries occurred among older ages and appeared to result less often from loss of control. Severe injuries resulting in deep soft tissue trauma and fracture/dislocations were 1.7 and 1.5 times, respectively, more frequent among ATV trauma than bicycling (p<0.01). In addition, ATV related injuries were located more frequently in the trunkal, hip, lower extremity, and spinal regions. Conversely, ATV related trauma bore significant similarities regarding body part and nature of the injury to both motor vehicle crash (MVC) and dirtbike related injuries. Akin to dirtbike and MVC related trauma, ATV related injuries more frequently required admission to the ward or intensive care unit compared to bicycling injuries (30.8% v 9.6%, p<0.0001), and used a proportionally larger amount of hospital resources with respect to overall in-hospital and intensive care unit days. Although ATVs may be considered recreational for children, their associated injury patterns, severity, and costs to the healthcare system more closely resemble those from motorized vehicles and are more significant than bicycling. Strict policy to reflect this must be developed and acknowledged by the public, industry, and legislative bodies.

  14. [Vernes/Augusti cancer assessment. Documentation 17].

    Science.gov (United States)

    Jallut, O

    1989-08-02

    The principles are: Determination of mucopolysaccharides, expressed as weight of mannose-galactose per liter of serum. Because of the non-specificity of this test in cancers, it is combined with other "more specific tests of the inflammatory condition" (orosomucoids and seromucoids). The floculation reaction of proteins through acidified copper acetate provokes the formation in the serum of a precipitate containing mainly beta and gamma globulins, frequently found in the blood of cancer patients, not specific to that condition but nevertheless "providing information on the development of cancers". Originally this test was used as a method of cancer diagnosis but, according to Augusti, it is now to be considered as nothing more than "a means of following up a cancerous state under the effect of treatment". The set of tests amounts to sFr. 150.-, to be repeated every six weeks. The cancerometry has been developed in the thirties by Dr. Alfred Vernes and was used as method of very approximate testing of the hepatic functions. The main promoter is at present Dr. Augusti in Paris. Augusti, in a study on the results obtained in his laboratory during one year (20,000 various examinations), claims to have found differing histograms in healthy and cancerous subjects: "The two reactions assume a correct method of observing the cancerous state." Up to now no clinical trials have been published.

  15. LITERATURA DE EXPLORAÇÕES E AVENTURAS: AS “VIAGENS EXTRAORDINÁRIAS” DE JÚLIO VERNE

    Directory of Open Access Journals (Sweden)

    Oswaldo Bueno Amorim Filho

    2008-12-01

    Full Text Available RESUMÉ: La forte croissance des études humanistes-culturelles au monde, dans les dernières decennies, a provoquéune rennaissance d’une ancienne collaboration entre la géographie et la littérature. Cet essai introductoirea pour objectif recouvrer une des manifestations littéraires le plus proches de la géographie, c’est a dire,la “littérature de voyages, explorations et aventures”.Cette littérature a eu son apogée dans l’Europe du XIXème siècle, surtout en Allemagne, au Royaume-Uni et en France. Dans ce dernier pays, l’écrivain Jules Verne est le meilleur exemple de ce type delittérature, avec sa grande collection de Voyages extraordinaires. Le but de cet essai est d’analyser lesconnexions de cette collection littéraire avec la géographie.

  16. Coupled carbon-nitrogen land surface modelling for UK agricultural landscapes using JULES and JULES-ECOSSE-FUN (JEF)

    Science.gov (United States)

    Comyn-Platt, Edward; Clark, Douglas; Blyth, Eleanor

    2016-04-01

    The UK is required to provide accurate estimates of the UK greenhouse gas (GHG; CO2, CH4 and N2O) emissions for the UNFCCC (United Nations Framework Convention on Climate Change). Process based land surface models (LSMs), such as the Joint UK Land Environment Simulator (JULES), attempt to provide such estimates based on environmental (e.g. land use and soil type) and meteorological conditions. The standard release of JULES focusses on the water and carbon cycles, however, it has long been suggested that a coupled carbon-nitrogen scheme could enhance simulations. This is of particular importance when estimating agricultural emission inventories where the carbon cycle is effectively managed via the human application of nitrogen based fertilizers. JULES-ECOSSE-FUN (JEF) links JULES with the Estimation of Carbon in Organic Soils - Sequestration and Emission (ECOSSE) model and the Fixation and Uptake of Nitrogen (FUN) model as a means of simulating C:N coupling. This work presents simulations from the standard release of JULES and the most recent incarnation of the JEF coupled system at the point and field scale. Various configurations of JULES and JEF were calibrated and fine-tuned based on comparisons with observations from three UK field campaigns (Crichton, Harwood Forest and Brattleby) specifically chosen to represent the managed vegetation types that cover the UK. The campaigns included flux tower and chamber measurements of CO2, CH4 and N2O amongst other meteorological parameters and records of land management such as application of fertilizer and harvest date at the agricultural sites. Based on the results of these comparisons, JULES and/or JEF will be used to provide simulations on the regional and national scales in order to provide improved estimates of the total UK emission inventory.

  17. The epidemiology of injury in ATV and motocross sports.

    Science.gov (United States)

    Larson, A Noelle; McIntosh, Amy L

    2012-01-01

    Off-road motorsports are popular in rural and suburban areas, and allow for racing, recreation, and easy access to backcountry destinations. This chapter will review the incidence and types of injuries sustained in off-road motorsports. We completed a structured review of motocross and all-terrain vehicle (ATV) injuries, assessing for injury rates, risk factors, and mortality figures. Information for this study was obtained from a PubMed search under the terms 'motocross', 'motorcross', 'all-terrain vehicles', 'injury', 'motorcycle', 'ATV'. Abstracts and articles in the English language from 1980 onward were reviewed. Further statistics were obtained from the US Consumer Product Safety Commission publications. Operating vehicles off-road requires coordination, experience, and training. Motocross is an organized sport with national associations governing the competition of highly trained athletes. ATVs are used both recreationally and commercially, typically for farming and ranching. ATV use appears more dangerous that motocross, with a higher mortality rate, disproportionately for children. Both sports continue to have high rates of head, spinal cord, and extremity injury. Future prospective studies in off-road motorsports should evaluate the risk factors for injury and target specific areas for injury prevention. Improved training programs, use and improvement of safety helmets, and for ATV use, limiting access to minors, may improve the overall safety of off-road motorsports. Copyright © 2012 S. Karger AG, Basel.

  18. Development and Qualification of ATV Propulsion Assemblies

    Science.gov (United States)

    Riehle, M.; Jost, R.

    2002-01-01

    In the frame of the development and operation of the International Space Station ISS, the European Space Agency ESA is not only contributing experiments and a laboratory module but also logistics capacity. This purpose of supplying the ISS shall be covered by an unmanned, Automated Transfer Vehicle (ATV) that will be launched for the first time in 2004 by Ariane 5. The development of the ATV is in close conjunction to the future Ariane 5 launch capacity of about 20 tons injected into low earth orbit. Thus this unmanned transporter will be a quite large space craft that is subjected to fulfil several mission objectives apart of only delivering cargo such as multiple automatic docking/de-docking, re-boost services and re-fuelling. For those reasons and due to its dimensions the propulsion sub-system is one of the most sophisticated in the field of space propulsion. Even safety issues of manned space flight have to be applied since the pressurised cargo section is part of the ISS when docked to the manned modules. This leads to by far the largest but also the most sophisticated propulsion system ever built in Europe. Astrium as one of the major partners of this european project is responsible for this major system that will be described in the paper. Focusing on the major core assemblies such as multi thruster platforms, pressure control system incl. safety and redundancy mechanisms as well as tanks and other components that completes a propulsion system. System Design and Qualification Starting from the basic criteria the paper will present the major performance requirements such as pressures, thrust levels and other parameters that led to the selection of major components of the system such as thrusters, valves, tanks, etc. Some of the component could be selected from off the shelve, whereas other core components such as the 200N Attitude Control and Braking Thrusters or Propellant Tanks had to be newly developed. The stepwise approach of development and careful

  19. Pediatric ATV Injuries in a Statewide Sample: 2004 to 2014.

    Science.gov (United States)

    Garay, Mariano; Hess, Joseph; Armstrong, Douglas; Hennrikus, William

    2017-08-01

    To establish the incidence, mortality rate, and fracture location of pediatric patients injured while using an all-terrain vehicle (ATV) over an 11-year period. A retrospective study using a state trauma database for patients ages 0 to 17 years who sustained injuries while using an ATV. Thirty-two pediatric and adult trauma centers within the state were evaluated from January 1, 2004, to December 31, 2014. The inclusion criteria were met by 1912 patients. The estimated mean annual incidence during the period of the study was 6.2 patients per 100 000 children in the pediatric population injuries. Although there was a 13.4% reduction in the incidence of ATV-related injuries in recent years, continued preventive guidelines are still necessary to avert these injuries in children and adolescents. Copyright © 2017 by the American Academy of Pediatrics.

  20. On-road all-terrain vehicle (ATV) fatalities in the United States.

    Science.gov (United States)

    Williams, Allan F; Oesch, Stephen L; McCartt, Anne T; Teoh, Eric R; Sims, Laurel B

    2014-09-01

    The study was designed to describe the characteristics of all-terrain vehicle (ATV) rider fatalities and fatal crashes involving ATVs that occur on public roads. Information on fatal crashes occurring on public roads during the years 2007-2011 was obtained from the Fatality Analysis Reporting System (FARS). There were 1,701 ATV rider deaths during the 5-year study period, including 1,482 drivers, 210 passengers, and 9 with unknown rider status. An additional 19 non-ATV occupants, primarily motorcyclists, died in crashes with ATVs. About half of the ATV passenger deaths were teenagers or younger, and the majority of passenger deaths were female. Ninety percent of the fatally injured drivers were 16 or older, and 90% were male. The crashes were most likely to occur in relatively rural states, and in rural areas within states. Only 13% of drivers and 6% of passengers killed wore helmets. Forty-three percent of the fatally injured drivers had blood alcohol concentrations (BACs) of 0.08% or greater. Seventy-five percent of the fatal crashes involved single ATVs; 5% involved multiple ATVs but no non-ATV vehicles, and 20% involved ATVs and non-ATVs, usually passenger vehicles. Speeding was reported by police as a contributing factor in the crash for 42% of ATV drivers in single-vehicle crashes and 19% of ATV drivers in multiple-vehicle crashes. Although ATVs are designed exclusively for off-road use, many ATV occupant deaths occur on roads, despite most states having laws prohibiting many types of on-road use. Attention needs to be given to ways to reduce these deaths. Copyright © 2014 National Safety Council and Elsevier Ltd. All rights reserved.

  1. Workspace and Kinematic Analysis of the VERNE machine

    CERN Document Server

    Kanaan, Daniel; Chablat, Damien

    2007-01-01

    This paper describes the workspace and the inverse and direct kinematic analysis of the VERNE machine, a serial/parallel 5-axis machine tool designed by Fatronik for IRCCyN. This machine is composed of a three-degree-of-freedom (DOF) parallel module and a two-DOF serial tilting table. The parallel module consists of a moving platform that is connected to a fixed base by three non-identical legs. This feature involves (i) a simultaneous combination of rotation and translation for the moving platform, which is balanced by the tilting table and (ii) workspace whose shape and volume vary as a function of the tool length. This paper summarizes results obtained in the context of the European projects NEXT ("Next Generation of Productions Systems").

  2. Land surface parameter optimisation through data assimilation: the adJULES system

    Science.gov (United States)

    Raoult, Nina; Jupp, Tim; Cox, Peter

    2017-04-01

    Land-surface models (LSMs) are crucial components of the Earth system models (ESMs) that are used to make coupled climate-carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. JULES is also extensively used offline as a land-surface impacts tool, forced with climatologies into the future. In this study, JULES is automatically differentiated with respect to JULES parameters using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimation system has been developed to search for locally optimum parameters by calibrating against observations. We present adJULES in a data assimilation framework and demonstrate its ability to improve the model-data fit using eddy-covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the five plant functional types (PFTs) in JULES. The optimised PFT-specific parameters improve the performance of JULES at over 85% of the sites used in the study, at both the calibration and evaluation stages. The new improved parameters for JULES are presented along with the associated uncertainties for each parameter.

  3. Simulation of the ATV Re-Entry Obsrvations

    Science.gov (United States)

    Bastida Virgili, B.; Krag, H.; Lips, T.; De Pasquale, E.

    2010-09-01

    The first ATV was launched on 9th March 2008 and, after a successful mission, the last phase was a controlled destructive re-entry on 29th September 2008, shortly after 13:30 UTC, in which the remains of the ATV and its load fell into the South Pacific Ocean. In order to better understand the re-entry processes, an insitu optical observation campaign was launched to record and analyze the ATV controlled re-entry with several instruments on board of two airplanes and also from the ISS. This observation campaign was successful and triggered several different still-ongoing studies on the extraction and analysis of data to draw conclusions on the adequacy of the re-entry break-up and explosion models used for the safety analysis of the ATV re-entry. This paper addresses the validation process for ESA’s model for re-entry survivability and on-ground risk assessment for explosive re-entry events using the observation data. The underlying rationale is to improve the models for the benefit of planning and execution of future controlled re-entries and in risk calculation in case of uncontrolled ones. The re-entry trajectory of the ATV, the explosive event and the trajectories of the fragments are simulated with the existing ESA tools and the EVOLVE explosion model. Additional software has been developed to simulate airborne sensor field of view(FOV) crossings based on the aircraft trajectories, attitude profile, sensor mounts and FOVs. Sensor performance and object radiation are modeled in order to generate synthetic images for the different sensors in the ISS and the two airplanes. These synthetic images and synthetic videos are compared with the available reentry observations of the ATV. This paper will present the software and techniques to generate synthetic imagery. It will give results of the comparison between the simulated and the real trajectories and fragmentation and explain the subsequent validation process of the ESA re-entry tools and the potential

  4. A randomized pilot study of tenofovir/emtricitabine (TDF/FTC + boosted atazanavir (ATV/r vs. raltegravir (RAL BID + ATV/r vs. RAL BID + ATV BID

    Directory of Open Access Journals (Sweden)

    C Cohen

    2012-11-01

    Full Text Available Patients virologically suppressed on TDF/FTC + ATV/r may require alternative regimens that maintain suppression while addressing some drug-related side effects. We explored two alternative regimens that replace RTV and/or TDF/FTC. This open-label exploratory pilot trial enrolled 43 patients on TDF/FTC + ATV/r. Subjects were randomized to one of three arms. Arm 1 (n=15 replaced TDF/FTC with RAL 400 mg BID while continuing ATV/r. Arm 2 (n=14 made two changes: TDF/FTC was stopped and RAL BID was used instead; ritonavir was stopped and ATV 300 mg BID was used. Arm CTL (n=14 continued the baseline (BL regimen. The week 48 final endpoint is summarized. The primary endpoint was maintaining virologic suppression (<40 c/mL; secondary endpoints compared safety measures. Overall mean age was 46, with 74% Caucasian, 21% black race and 12% female; similar characteristics noted across arms. Through week 48, all but two patients maintained virologic suppression; both virologic failures (>200 c/mL on two consecutive tests were on arm 2; both reported adherence problems and no resistance mutations were detected. Overall CD4 counts were 534/mm3 at BL and 555/mm3 at week 48. There was a significant CD4 cell count difference favoring CTL (+52/mm3 vs. arm 2 (−14/mm3, p=0.03. No significant differences across arms were noted in lipid fractions or other lab tests. There were no clinically significant EKG changes across arms. Among AEs of interest through week 48, there were more neurologic AEs on arm 1 (n=7 and 2 (n=6 vs. CTL (n=1, and more musculoskeletal events noted on arm 2 (n=7 vs. arm 1 (n=3 and CTL (n=1. Quality of life was measured with a self-assessment Likert scale. Scores were similar across arms despite the BID dosing in two arms. Self-reported adherence using 3-day recall was>95% in all three arms at both baseline and week 48. In this randomized pilot study, two of the three arms maintained virologic suppression in all subjects; there were two virologic

  5. La Arquitectura moderna y la pertinencia de la arquitectura vernácula

    OpenAIRE

    Contreras Arias, Manuel

    2009-01-01

    El objetivo es entender las posibles relaciones entre arquitectura moderna y arquitectura vernácula, y determinar los vínculos de éstas manifestaciones culturales a pesar de las diferencias aparentes tecnológicas y fundamentales. En el presente caso confrontaremos la arquitectura moderna mexicana habitacional con lo ocurrido en la arquitectura moderna ecuatoriana, así como analizar las relaciones existentes entre la arquitectura vernácula mexicana y la ecuatoriana con el propósito de encontra...

  6. Interpretación bioclimática de la arquitectura vernácula

    OpenAIRE

    Paniagua Padilla, Diego

    2015-01-01

    La ‘arquitectura vernácula’ desarrolló la primera adecuación entre el clima, las necesidades humanas y la construcción sostenible. En este sentido, la ‘arquitectura bioclimática’ de la que hablamos hoy en día es una interpretación de la arquitectura a efectos del clima sobre el hombre. Podríamos entenderla como una arquitectura popular evolucionada y adaptada. ¿Pero es lo mismo arquitectura vernácula que popular? ¿Y arquitectura bioclimática? ¿Es lo que muchos denominan ‘arquitectura sostenib...

  7. La Arquitectura moderna y la pertinencia de la arquitectura vernácula

    OpenAIRE

    Contreras Arias, Manuel

    2009-01-01

    El objetivo es entender las posibles relaciones entre arquitectura moderna y arquitectura vernácula, y determinar los vínculos de éstas manifestaciones culturales a pesar de las diferencias aparentes tecnológicas y fundamentales. En el presente caso confrontaremos la arquitectura moderna mexicana habitacional con lo ocurrido en la arquitectura moderna ecuatoriana, así como analizar las relaciones existentes entre la arquitectura vernácula mexicana y la ecuatoriana con el propósito de encontra...

  8. Interpretación bioclimática de la arquitectura vernácula

    OpenAIRE

    Paniagua Padilla, Diego

    2015-01-01

    La ‘arquitectura vernácula’ desarrolló la primera adecuación entre el clima, las necesidades humanas y la construcción sostenible. En este sentido, la ‘arquitectura bioclimática’ de la que hablamos hoy en día es una interpretación de la arquitectura a efectos del clima sobre el hombre. Podríamos entenderla como una arquitectura popular evolucionada y adaptada. ¿Pero es lo mismo arquitectura vernácula que popular? ¿Y arquitectura bioclimática? ¿Es lo que muchos denominan ‘arquitectura sostenib...

  9. 40 CFR 1051.107 - What are the exhaust emission standards for all-terrain vehicles (ATVs) and offroad utility...

    Science.gov (United States)

    2010-07-01

    ... powered by the following fuels: (1) Natural gas-fueled ATVs: NMHC emissions. (2) Alcohol-fueled ATVs: THCE... operating life from advertisements or other marketing materials for any vehicles in the engine family....

  10. 32 CFR 636.29 - Go-carts, minibikes, and all terrain vehicles (ATV's).

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Go-carts, minibikes, and all terrain vehicles... (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.29 Go-carts, minibikes, and all terrain vehicles (ATV's). (a) Operators of “go-carts,” “minibikes,” and ATV's 16 years of age or older, must comply with...

  11. [The wanderings of Jules Cloquet and Gustave Flaubert].

    Science.gov (United States)

    Dumont, M

    1988-01-01

    This is the story of a picaresque journey in France and in Corsica of Jules Cloquet (1790-1883), the French anatomist who described the well-known Cloquet's node and of Gustave Flaubert (1821-1880), the famous author of "Madame Bovary" and of many others novels. They were two vagabonds, Cloquet watching with slackness the young womanizering Flaubert. At 64 years of age, the lazy and meddlesome Cloquet stopped operating and writing. Surrounded by honors, he died at the age of 93, leaving his eponym to the Cloquet's node.

  12. ATV Accidents continue to be a major public health issue in West Virginia.

    Science.gov (United States)

    Rose, William D; Helmpkamp, James C

    2005-01-01

    All-terrain vehicle (ATV) riding continues to be a major public health problem in West Virginia because the state leads the nation in the rate of deaths from ATV incidents and has significantly higher death rates than all five of the bordering states. Annually, there are 24 deaths a year in West Virginia due to ATV accidents and thousands of nonfatal injuries. Sporting events using ATVs such as motocross racing have added to the burden of caring for patients who are injured in recreational activities. We report a case study of 10 patients treated over an 18-hour period in a state trauma center for injuries received while riding ATVs casually and in competition. The addition of these 10 patients to the other 108 patients seen in the ED during this period totally disrupted patient flow, caused significant delays in care of the non-trauma patients, and tied up the Radiology Department and operating rooms for an extended period.

  13. Clinical features and risk factors for atazanavir (ATV-associated urolithiasis: a case-control study.

    Directory of Open Access Journals (Sweden)

    Matthieu Lafaurie

    Full Text Available OBJECTIVES: Clinical features and risk factors for atazanavir (ATV-associated urolithiasis have not been fully investigated. METHODS: We reviewed all cases of ATV-containing urolithiasis identified by infrared spectrophotometry among HIV-infected patients over a 5-year period to describe their clinical features and outcome. A case-control study was performed to identify risk factors associated with ATV-associated urolithiasis using univariate and multivariate logistic regression analyses. RESULTS: 30 cases of ATV-associated urolithiasis were analyzed. Patients were mostly men (87%, median age: 45.5 years, median CD4 cell count: 443 cells/µL and 97% had plasma HIV RNA level <50 cp/mL. Median time between the initiation of ATV-containing regimen and the diagnosis of urolithiasis was 3.1 years. Patients presented with flank pain in 90% and macroscopic hematuria in 82.6%, 34% had renal dysfunction and 44.8% needed ureteroscopic treatment. In univariate analysis, chronic hepatitis C, a history of urolithiasis, prior use of indinavir, ATV duration, undetectable plasma HIV RNA, use of ritonavir as a booster and serum free bilirubin level were associated with ATV-urolithiasis. Multivariate models retained serum free bilirubin level (OR: 2.31, p<0.02 and either ATV duration (OR:  = 1.42, p = <0.03 or a history of urolithiasis (OR = 4.79, p<0.02 when adjusting on serum free bilirubin level as risk factors associated with urolithiasis. CONCLUSIONS: ATV-containing urolithiasis are associated with frank clinical symptoms and may require surgical intervention. A high serum bilirubin level, a long exposure to ATV and a history of urolithiasis are risk factors for this rare adverse event.

  14. The launching of the construction of the Jules Horowitz Reactor; Lancement de la construction du reacteur de recherche Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2007-03-15

    In March 2007 the French deputy minister of industry has officially launched the construction of the new research reactor called Jules Horowitz (RJH) on the Cea site of Cadarache. RJH, that is due to operate in 2014, will be used to study the aging process of irradiated materials in any type of reactors, the behaviour of new nuclear fuels irradiated in different configurations and scenarios, and to produce radionuclides for nuclear medicine and high-quality doped silicon for the electronics industry. The investment that reaches 500 million euros is dispatched between Cea (50%), EDF (20%), Areva (10%) and foreign contributors (20%). (A.C.)

  15. Jules Germain Cloquet (1790-1883)--drawing master and anatomist.

    Science.gov (United States)

    Loukas, Marios; El-Sedfy, Abraham; Tubbs, R Shane; Wartman, Christopher

    2007-11-01

    Jules Germain Cloquet, the famed French anatomist, surgeon, and professor, may not be remembered as one of the pioneers of hernia surgery; however, his contributions have provided surgeons with detailed anatomical descriptions that have been useful in developing innovative surgical techniques. Cloquet has many eponyms associated with him, including: Cloquet's fascia, Cloquet's gland or lymph node of Cloquet, Cloquet's hernia, Cloquet's ligament, Cloquet's canal, and Cloquet's septum. A man blessed with artistic talents, Cloquet was the author of many theses, as well as anatomical volumes that were comparable to the works of other great anatomists of his time. His first thesis, entitled Recherches Anatomiques sur les Hernies de l'Abdomen, described the locations where inguinal and crural herniae are more likely to occur in terms of the cremaster muscle, the peritoneum, and the spermatic vessels. Wax sculpture training required extensive knowledge in the natural sciences, anatomy, physiology, and pathology, as were acquired by Jules Cloquet as a pupil of Achille-Cléophas Flaubert, the father of the famous French novelist Gustave Flaubert (author of Madame Bovary). Cloquet attracted many pupils with his innovative teaching style and implementation of anatomical preparations, drawings, and sketches on the black board with chalk. The legacy of this famed individual lives on today in the anatomical structures described by Cloquet.

  16. Trailer Live Webcast Edoardo Amaldi ATV 3 launch

    CERN Multimedia

    CERN Visual Media Office

    2012-01-01

    Edoardo Amaldi, CERN’s first Secretary General and a driving force for the creation of this Laboratory, was also one of the founding fathers of ESA, the European Space Agency. On Friday March 23 ESA' s ATV3, the third Automated Transfer Vehicle to the International Space Station, named after Edoardo Amaldi will take off from Europe’s spaceport in Kourou on an Ariane 5 rocket at 05:34 am CET to dock with the International Space Station 5 days later. CERN will celebrate this event with a live webcast to retrace the vision of Edoardo Amaldi which led to the creation of the most important European Research Institutions on Friday, March 23rd, 15:00 CET (14 GMT, 10 EDT)

  17. Land-surface parameter optimisation using data assimilation techniques: the adJULES system V1.0

    Science.gov (United States)

    Raoult, Nina M.; Jupp, Tim E.; Cox, Peter M.; Luke, Catherine M.

    2016-08-01

    Land-surface models (LSMs) are crucial components of the Earth system models (ESMs) that are used to make coupled climate-carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. JULES is also extensively used offline as a land-surface impacts tool, forced with climatologies into the future. In this study, JULES is automatically differentiated with respect to JULES parameters using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimation system has been developed to search for locally optimum parameters by calibrating against observations. This paper describes adJULES in a data assimilation framework and demonstrates its ability to improve the model-data fit using eddy-covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the five plant functional types (PFTs) in JULES. The optimised PFT-specific parameters improve the performance of JULES at over 85 % of the sites used in the study, at both the calibration and evaluation stages. The new improved parameters for JULES are presented along with the associated uncertainties for each parameter.

  18. A new MTR fuel for a new MTR reactor: UMo for the Jules Horowitz reactor

    Energy Technology Data Exchange (ETDEWEB)

    Guigon, B. [CEA Cadarache, F-13108 Saint Paul lez Durance (France); Vacelet, H. [CERCA, Romans (France); Dornbusch, D. [Technicatome, Aix en Provence (France)

    2000-07-01

    Within some years, the Jules Horowitz Reactor will be the only working experimental reactor (material and fuel testing reactor) in France. It will have to provide facilities for a wide range of needs from activation analysis to power reactor fuel qualification. In this paper the main characteristics of the Jules Horowitz Reactor are presented. Safety criteria are explained. Finally, merits and disadvantages of UMo compared to the standard U{sub 3}Si{sub 2} fuel are discussed. (author)

  19. Arquitectura vernácula y mezquitas sudanesas en Burkina Faso y Níger

    OpenAIRE

    Orihuela, Antonio

    2007-01-01

    Se analiza la casa vernácula de las etnias Bobo, Lobi y Gurunsi en las sabanas arboladas de Burkina Faso, así como las de la etnia Hausa en la ciudad de ZInder (Nigér). También se describen las mezquitas de tipo sudanés existentes en Agadez y Zinder (Níger), Bobo-Dioulasso, Ouahabou y Bani (Burkina Faso).

  20. Vivienda efímera urbana: ¿arquitectura vernácula?

    OpenAIRE

    Jaime Enrique Gómez M.

    2010-01-01

    El artículo se publica como etapa inicial de una investigación enfocada en el estudio de la vivienda efímera urbana, con el fin de encontrar en ésta principios aplicables a otras arquitecturas. Partiendo de la definición de este tipo de arquitectura, y con el fin de empezar a buscar metodologías adecuadas para su estudio, se plantea la pregunta sobre si ésta puede considerarse arquitectura vernácula. Para responder a la pregunta, se hace una revisión bibliográfica de algunos de los principale...

  1. Proyecto europeo versus: lecciones de la arquitectura vernácula para una arquitectura contemporánea sostenible

    OpenAIRE

    Mileto, Camilla (Coordinador); Vegas López-Manzanares, Fernando; García Soriano, Lidia; Cristini, Valentina

    2015-01-01

    La arquitectura vernácula representa una gran fuente de investigación para definir los principios que pueden guiar el diseño de una nueva arquitectura contemporánea sostenible. La arquitectura tradicional y sus métodos y estrategias están de algún modo infravaloradas y no suelen emplearse en la nueva arquitectura. Por ello, el principal objetivo del proyecto VerSus (financiado por la Unión Europea, Culture Programme 2007 - 2013) ha sido conocer y analizar la arquitectura vernácula para extrae...

  2. Fabrication of a Textured Non-Magnetic Ni-12at.%V Alloy Substrate for Coated Conductors

    DEFF Research Database (Denmark)

    Gao, M. M.; Grivel, Jean-Claude; Suo, H. L.;

    2011-01-01

    Ni-12at.%V alloy is a promising candidate for non-magnetic cube textured metallic substrates used for high temperature coated conductors. In this work, a textured Ni-12at.%V substrate has been fabricated by powder metallurgy route. After cold rolling and recrystallization annealing, a cube texture...

  3. A Transportation Model for a Space Colonization and Manufacturing System: A Q-GERT Simulation.

    Science.gov (United States)

    1982-12-01

    their audiences glimpses of what could be. Jules Verne , considered by many people as the father of science fiction, fortold many of our modern...Publishing Company, 1966. 2. Verne , Jules . Emm iha Eari. Jk ±ha t ! . Paris: 1873. 3. Verne , Jules . f nan a Comet. Paris: 1878. 4. Salkeld, Robert

  4. All Terrain Vehicle (ATV crashes in an unregulated environment: A prospective study of 56 cases

    Directory of Open Access Journals (Sweden)

    Mushrek Alani

    2012-05-01

    Full Text Available All terrain vehicle (ATV use is increasing at a rapid pace in settings without proper safety regulations. Aim: To define injury patterns, impairments, and outcomes among patients injured in ATV crashes; to determine prevalence of protective equipment use; and to define the potential role of injury prevention in addressing the problem. Methods: During a recent 10 month period, 56 patients were reported as injured in ATV crashes seriously enough to require admission and were prospectively entered into a study-specific database. Patient demographics, site of crash, prior ATV experience, and use of safety equipment were recorded. Injuries were characterized by body system and tabulated. Outcomes, including deaths and impairments, were defined. Results: There were 47 males (84% and 9 females (16%. Most injuries occurred in patients older than 18 years, but 20% occurred in children less than 14 years of age. Helmet use was confirmed in 12%. Three patients died (5% mortality. Significant disability occurred in 19 patients (34% and was permanent in 4 (7%. Head, face and musculoskeletal injuries were most common. Conclusions: ATV crashes can cause serious injuries including death and permanent disability. The lack of awareness of the injury potential for this popular recreational activity has escalated the risk of injury, and the absence of safety programs and regulations has further aggravated the problem. Based on these data, a public education program, compulsory use of helmets and other protective clothing, and penalties for non-compliance should be implemented. Interventions at recreation sites and the point of ATV sale may be most beneficial.

  5. Human Flight Batteries NI-CD/LI-MNO2

    Science.gov (United States)

    Lagattu, Benoit; Granger, Jean-Francois

    2011-10-01

    The ATV, as European space tug for the International Space Station, can be truly considered as a manned platform, when it comes to safety requirements. On board batteries have to comply with stringent requirements and insure a fully safe operation all along the mission. Though,ATV batteries manufacturer designed developed and supplied all onboard primary and rechargeable batteries required for the ATV Jules Verne. The batteries for future ATV missions will be supplied until 2015 within the framework of a long-term contract with the ATV manufacturer. Use of primary lithium batteries (Li-MnO2) for collision avoidance and de-orbitation offer a particular advantage for spacecraft as their high specific energy helps reducing the overall weight. They also comply with safety qualifications for manned flight missions. 100 minutes after lift-off, the ATV became a fully automated spacecraft navigating towards the ISS. During this phase, its main power is derived from four large solar wings with backup provided by four nickel- cadmium (Ni-Cd) batteries. Once docked, the Ni-Cd batteries will continue to provide power for the ATV for about 30 minutes (the approximate duration solar panels are eclipsed by the Earth's shadow) each 90-minute orbit. Ni-Cd batteries offer a particularly robust and reliable solution for this application, with a spaceflight heritage that goes back over 40 years. This paper outlines how Ni-Cd and Li-MnO2 batteries performed during flight operations of Jules Verne spacecraft and how they met performances predictions through lift off, orbital flight and atmosphere reentry.

  6. A new MTR fuel for a new MTR reactor: UMo for the Jules Horowitz reactor

    Energy Technology Data Exchange (ETDEWEB)

    Guigon, B. [CEA Cadarache, Dir. de l' Energie Nucleaire DEN, Reacteur Jules Horowitz, 13 - Saint-Paul-lez-Durance (France); Vacelet, H. [Compagnie pour l' Etude et la Realisation de Combustibles Atomiques, CERCA, Etablissement de Romans, 26 (France); Dornbusch, D. [Technicatome, Service d' Architecture Generale, 13 - Aix-en-Provence (France)

    2003-07-01

    Within some years, the Jules Horowitz Reactor will be the only working experimental reactor (material and fuel testing reactor) in France. It will have to provide facilities for a wide range of needs: from activation analysis to power reactor fuel qualification. In this paper will be presented the main characteristics of the Jules Horowitz Reactor: its total power, neutron flux, fuel element... Safety criteria will be explained. Finally merits and disadvantages of UMo compared to the standard U{sub 3}Si{sub 2} fuel will be discussed. (authors)

  7. Quantifying the Impact of Tropospheric Ozone on Crops Productivity at regional scale using JULES-crop

    Science.gov (United States)

    Leung, F.

    2016-12-01

    Tropospheric ozone (O3) is the third most important anthropogenic greenhouse gas. It is causing significant crop production losses. Currently, O3 concentrations are projected to increase globally, which could have a significant impact on food security. The Joint UK Land Environment Simulator modified to include crops (JULES-crop) is used here to quantify the impacts of tropospheric O3 on crop production at the regional scale until 2100. We evaluate JULES-crop against the Soybean Free-Air-Concentration-Enrichment (SoyFACE) experiment in Illinois, USA. Experimental data from SoyFACE and various literature sources is used to calibrate the parameters for soybean and ozone damage parameters in soybean in JULES-crop. The calibrated model is then applied for a transient factorial set of JULES-crop simulations over 1960-2005. Simulated yield changes are attributed to individual environmental drivers, CO2, O3 and climate change, across regions and for different crops. A mixed scenario of RCP 2.6 and RCP 8.5 climatology and ozone are simulated to explore the implication of policy. The overall findings are that regions with high ozone concentration such as China and India suffer the most from ozone damage, soybean is more sensitive to O3 than other crops. JULES-crop predicts CO2 fertilisation would increase the productivity of vegetation. This effect, however, is masked by the negative impacts of tropospheric O3. Using data from FAO and JULES-crop estimated that ozone damage cost around 55.4 Billion USD per year on soybean. Irrigation improves the simulation of rice only, and it increases the relative ozone damage because drought can reduce the ozone from entering the plant stomata. RCP 8.5 scenario results in a high yield for all crops mainly due to the CO2 fertilisation effect. Mixed climate scenarios simulations suggest that RCP 8.5 CO2 concentration and RCP 2.6 O3 concentration result in the highest yield. Further works such as more crop FACE-O3 experiments and more Crop

  8. Kuidas meeldib välismaalastele Eestis [õppida]? / Shazia Javed, Charina de Asis, Adam Luke Vern-Barnett, Predrag Tasevski

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid välisüliõpilased: rahvusvahelisi suhteid õppiv Charina de Asis Filipiinidelt, magistriõppes rahvusvahelist õigust õppiv Adam Luke Vern-Barnett Austraaliast, küberkaitset õppiv Predrag Tasevski Makedooniast ja tarkvara arendust õppiv Shazia Javed Pakistanist

  9. Latín y lenguas vernáculas en los poemas amorosos de los "Carmina Burana"

    OpenAIRE

    2016-01-01

    La intención de este artículo es explicar el uso de la lengua latina y de las lenguas vernáculas en los poemas amorosos de los Carmina Burana. The intent of this article is to explain the use of the Latin language and vernacular languages in the love poems of Carmina Burana.

  10. On the Verbal Art of a Modern Painter: The Work of Jules Kirschenbaum.

    Science.gov (United States)

    Gandelman, Claude

    1989-01-01

    Notes that Jules Kirschenbaum, a modern American artist whose work integrates inscriptions and figurative painting, studied under the masters of abstract expressionism yet exhibited with protagonists of "magic realism." States that his later work took a wholly different turn--it became art about meaning and the "meaning of meaning." (RS)

  11. Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection.

    Science.gov (United States)

    Cotter, Jennifer D; Storfer, Andrew; Page, Robert B; Beachy, Christopher K; Voss, S Randal

    2008-10-20

    Very little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize gene expression responses of axolotls (Ambystoma mexicanum) to an emerging viral pathogen, Ambystoma tigrinum virus (ATV). At 0, 24, 72, and 144 hours post-infection, spleen and lung samples were removed for estimation of host mRNA abundance and viral load. A total of 158 up-regulated and 105 down-regulated genes were identified across all time points using statistical and fold level criteria. The presumptive functions of these genes suggest a robust innate immune and antiviral gene expression response is initiated by A. mexicanum as early as 24 hours after ATV infection. At 24 hours, we observed transcript abundance changes for genes that are associated with phagocytosis and cytokine signaling, complement, and other general immune and defense responses. By 144 hours, we observed gene expression changes indicating host-mediated cell death, inflammation, and cytotoxicity. Although A. mexicanum appears to mount a robust innate immune response, we did not observe gene expression changes indicative of lymphocyte proliferation in the spleen, which is associated with clearance of Frog 3 iridovirus in adult Xenopus. We speculate that ATV may be especially lethal to A. mexicanum and related tiger salamanders because they lack proliferative lymphocyte responses that are needed to clear highly virulent iridoviruses. Genes identified from this study provide important new resources to investigate ATV disease pathology and host-pathogen dynamics in natural populations.

  12. Multi-site evaluation of the JULES land surface model using global and local data

    Directory of Open Access Journals (Sweden)

    D. Slevin

    2015-02-01

    Full Text Available This study evaluates the ability of the JULES land surface model (LSM to simulate photosynthesis using local and global data sets at 12 FLUXNET sites. Model parameters include site-specific (local values for each flux tower site and the default parameters used in the Hadley Centre Global Environmental Model (HadGEM climate model. Firstly, gross primary productivity (GPP estimates from driving JULES with data derived from local site measurements were compared to observations from the FLUXNET network. When using local data, the model is biased with total annual GPP underestimated by 16% across all sites compared to observations. Secondly, GPP estimates from driving JULES with data derived from global parameter and atmospheric reanalysis (on scales of 100 km or so were compared to FLUXNET observations. It was found that model performance decreases further, with total annual GPP underestimated by 30% across all sites compared to observations. When JULES was driven using local parameters and global meteorological data, it was shown that global data could be used in place of FLUXNET data with a 7% reduction in total annual simulated GPP. Thirdly, the global meteorological data sets, WFDEI and PRINCETON, were compared to local data to find that the WFDEI data set more closely matches the local meteorological measurements (FLUXNET. Finally, the JULES phenology model was tested by comparing results from simulations using the default phenology model to those forced with the remote sensing product MODIS leaf area index (LAI. Forcing the model with daily satellite LAI results in only small improvements in predicted GPP at a small number of sites, compared to using the default phenology model.

  13. The climate responses of tropical and boreal ecosystems with an improved land surface model (JULES)

    Science.gov (United States)

    Harper, Anna; Friedlingstein, Pierre; Cox, Peter; Wiltshire, Andy; Jones, Chris

    2016-04-01

    The Joint UK Land Environment Simulator (JULES) is the land surface of the next generation UK Earth System Model (UKESM1). Recently, JULES was updated with new plant functional types and physiology based on a global plant trait database. These developments improved the simulation of terrestrial gross and net primary productivity on local and global scales, and enabled a more realistic representation of the global distribution of vegetation. In this study, we explore the present-day distribution of ecosystems and their vulnerability to climate change in JULES with these improvements, focusing on tropical and boreal ecosystems. Changes to these ecosystems will have implications for biogeophysical and biogeochemical feedbacks to climate change and need to be understood. First, we examine the simulated and observed rainforest-savannah boundary, which is strongly related to annual precipitation and the maximum climatological water deficit. Second, we assess the length of growing season and biomass stored in boreal ecosystems, where 20th century warming has likely extended the growing season. In each case, we first evaluate the ability of JULES to capture observed climate-vegetation relationships and trends. Finally, we run JULES to 2100 using climate data from 3 models and 2 RCP scenarios, and examine potential 21st century changes to these ecosystems. For example, do the tropical forests shrink in response to changes in tropical rainfall seasonality? And, how does the composition of boreal ecosystems change in response to climate warming? Given the potential for climate feedbacks and the inherent value in these ecosystems, it is essential to assess their responses to a range of climate change scenarios.

  14. Kinematic Analysis of a Serial - Parallel Machine Tool: the VERNE machine

    CERN Document Server

    Kanaan, Daniel; Chablat, Damien; 10.1016/j.mechmachtheory.2008.03.002

    2008-01-01

    The paper derives the inverse and the forward kinematic equations of a serial - parallel 5-axis machine tool: the VERNE machine. This machine is composed of a three-degree-of-freedom (DOF) parallel module and a two-DOF serial tilting table. The parallel module consists of a moving platform that is connected to a fixed base by three non-identical legs. These legs are connected in a way that the combined effects of the three legs lead to an over-constrained mechanism with complex motion. This motion is defined as a simultaneous combination of rotation and translation. In this paper we propose symbolical methods that able to calculate all kinematic solutions and identify the acceptable one by adding analytical constraint on the disposition of legs of the parallel module.

  15. Application of ATV1100 MV Drives in Mining Long Distance Belt Conveyer%ATV1100高压变频器在煤矿长距离皮带机上的应用

    Institute of Scientific and Technical Information of China (English)

    张登山; 王海天; 余博

    2012-01-01

    Long distance belt conveyer is the key equipment of coal transportation, coal is transported by belt conveyer through coal laneway when be excavated. This thesis presented Schneider MV drives ATV1100 application in coal mining long distance conveyer,described the requirement of belt conveyer equipment to MV drives according to system control diagram,and discussed how to use ATV1100 integrated function to fulfill these requirements. Meanwhile, ATV1100 MV drives technical advantage in coal mining belt conveyer application was summarized.%长距离带式输送机是煤碳运输的关键设备,矿井采煤机掘进出来的煤通过煤大巷带式输送机直接将原煤送入主斜井皮带.介绍了施耐德ATV1100高压变频器在矿井长距离皮带机上的应用.根据控制系统框图描述了带式皮带机对高压变频设备的具体要求,并论述了如何利用ATV1100内置的功能设计实现这些要求.同时,总结了ATV1100高压变频器在矿井皮带机应用中的技术优势.

  16. [Professor Jules Gavarret (1809-1890) and the application of mathematics and physics to medicine].

    Science.gov (United States)

    Beyneix, A

    2001-01-01

    Professor Jules Gavarret has undertaken pretigious offices, has accumulated various titles and honours and has left an abundant bibliography about physics and chemistry of life phenomenon. To recount the career of one of the academics who were benefited the traditional medicine of the progress achieved in physical and mathematical sciences give us the opportunity of recalling one of the great Parisian personalities of 19th Century who had not been appreciated for too long.

  17. Pierre Samuel et Jules Vuillemin : mathématiques et philosophie

    OpenAIRE

    2014-01-01

    National audience; In this article I aim to present an actual modality of relationship between mathematics and philosophy. To this purpose, I will consider a relatively recent project in philosophy of mathematics by taking as a case study Pierre Samuel's and Jules Vuillemin's reflections and contributions dealing with a general concept of structure in line with Nicolas Bourbaki, and by examining more specifically the notion of universal problem.; Je me propose dans cet article de présenter un...

  18. Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV infection

    Directory of Open Access Journals (Sweden)

    Beachy Christopher K

    2008-10-01

    Full Text Available Abstract Background Very little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize gene expression responses of axolotls (Ambystoma mexicanum to an emerging viral pathogen, Ambystoma tigrinum virus (ATV. Result At 0, 24, 72, and 144 hours post-infection, spleen and lung samples were removed for estimation of host mRNA abundance and viral load. A total of 158 up-regulated and 105 down-regulated genes were identified across all time points using statistical and fold level criteria. The presumptive functions of these genes suggest a robust innate immune and antiviral gene expression response is initiated by A. mexicanum as early as 24 hours after ATV infection. At 24 hours, we observed transcript abundance changes for genes that are associated with phagocytosis and cytokine signaling, complement, and other general immune and defense responses. By 144 hours, we observed gene expression changes indicating host-mediated cell death, inflammation, and cytotoxicity. Conclusion Although A. mexicanum appears to mount a robust innate immune response, we did not observe gene expression changes indicative of lymphocyte proliferation in the spleen, which is associated with clearance of Frog 3 iridovirus in adult Xenopus. We speculate that ATV may be especially lethal to A. mexicanum and related tiger salamanders because they lack proliferative lymphocyte responses that are needed to clear highly virulent iridoviruses. Genes identified from this study provide important new resources to investigate ATV disease pathology and host-pathogen dynamics in natural populations.

  19. Assimilating ESA-CCI Soil Moisture into the JULES-EMPIRE Data Assimilation System

    Science.gov (United States)

    Quaife, T. L.; Black, E.; Browne, P.; Lewis, J.

    2015-12-01

    Land surface models, such as the Joint UK Land Environment Simulator (JULES, the land surface component of the Hadley Centre models) are used in a wide variety of applications, such as climate modelling, flood prediction and crop yield forecasting. However, how best to implement Data Assimilation (DA) for these models remains an open question. At a fundamental level these models are very different from atmospheric models for which traditional DA was developed. This poster describes the integration of JULES with the EMPIRE framework. EMPIRE (Employing MPI for Researching Ensembles) implements a test bed for ensemble based DA techniques that makes use of MPI message passing to exploit all available processing power. In particular EMPIRE contains several flavours of Particle Filter which show promise for the land surface DA problem. Examples of assimilating soil moisture observations from the ESA CCI data set into JULES are given for a number of sites in Africa. The model ensemble is generated by considering uncertainty in the driving data taken from the TAMSAT operational rainfall product. The results show considerable improvement in the modelled soil moisture and in particular the seasonal timing of the soil wetness.

  20. Performance of the JULES land surface model for UK Biogenic VOC emissions

    Science.gov (United States)

    Hayman, Garry; Comyn-Platt, Edward; Vieno, Massimo; Langford, Ben

    2017-04-01

    Emissions of biogenic non-methane volatile organic compounds (NMVOCs) are important for air quality and tropospheric composition. Through their contribution to the production of tropospheric ozone and secondary organic aerosol (SOA), biogenic VOCs indirectly contribute to climate forcing and climate feedbacks [1]. Biogenic VOCs encompass a wide range of compounds and are produced by plants for growth, development, reproduction, defence and communication [2]. There are both biological and physico-chemical controls on emissions [3]. Only a few of the many biogenic VOCs are of wider interest and only two or three (isoprene and the monoterpenes, α- and β-pinene) are represented in chemical transport models. We use the Joint UK Land Environment Simulator (JULES), the UK community land surface model, to estimate biogenic VOC emission fluxes. JULES is a process-based model that describes the water, energy and carbon balances and includes temperature, moisture and carbon stores [4, 5]. JULES currently provides emission fluxes of the 4 largest groups of biogenic VOCs: isoprene, terpenes, methanol and acetone. The JULES isoprene scheme uses gross primary productivity (GPP), leaf internal carbon and the leaf temperature as a proxy for the electron requirement for isoprene synthesis [6]. In this study, we compare JULES biogenic VOC emission estimates of isoprene and terepenes with (a) flux measurements made at selected sites in the UK and Europe and (b) gridded estimates for the UK from the EMEP/EMEP4UK atmospheric chemical transport model [7, 8], using site-specific or EMEP4UK driving meteorological data, respectively. We compare the UK-scale emission estimates with literature estimates. We generally find good agreement in the comparisons but the estimates are sensitive to the choice of the base or reference emission potentials. References (1) Unger, 2014: Geophys. Res. Lett., 41, 8563, doi:10.1002/2014GL061616; (2) Laothawornkitkul et al., 2009: New Phytol., 183, 27, doi

  1. Representation of Dissolved Organic Carbon in the JULES Dynamic Global Vegetation Model

    Science.gov (United States)

    Nakhavali, Mahdi; Friedlingstein, Pierre; Guenet, Bertrand; Ciais, Philip

    2017-04-01

    Current global models of the carbon cycle consider only vertical gas exchanges between terrestrial or oceanic reservoirs and the atmosphere, hence not considering lateral transport of carbon from the continent to the oceans. This also means that such models implicitly consider that all the CO2 which is not respired to the atmosphere is stored on land, hence overestimating the land sink of carbon. Moving toward a boundless carbon cycle that is integrating the whole continuum from land to ocean to atmosphere is needed in order to better understand Earth's carbon cycle and to make more reliable projection of its future. Here we present an original representation of Dissolved Organic Carbon (DOC) processes in the Joint UK Land Environment Simulator (JULES). The standard version of JULES represent energy, water and carbon cycles and exchanges with the atmosphere, but only account for water run-off, not including export of carbon from terrestrial ecosystems to the aquatic environments. The aim of the project is to include in JULES a representation of DOC production in terrestrial soils, due to incomplete decomposition of organic matter, its decomposition to the atmosphere, and its export to the river network by leaching. In new developed version of JULES (JULES-DOCM), DOC pools, based on their decomposition rate, are classified into labile and recalcitrant within 3 meters of soil. Based on turnover rate, DOC coming from plant material pools and microbial biomass is directed to labile pool, while DOC from humus is directed to recalcitrant pool. Both of these pools have free (dissolved) and locked (adsorbed) form where just the free pool is subjected to decomposition and leaching. DOC production and decomposition are controlled by rate modifiers (moisture, temperature, vegetation fraction and decomposition rate) at each soil layer. Decomposed DOC is released to the atmosphere following a fixed carbon use efficiency. Leaching accounts for both surface (runoff) and

  2. The Atypical Response Regulator AtvR Is a New Player in Pseudomonas aeruginosa Response to Hypoxia and Virulence.

    Science.gov (United States)

    Kaihami, Gilberto Hideo; Breda, Leandro Carvalho Dantas; de Almeida, José Roberto Fogaça; de Oliveira Pereira, Thays; Nicastro, Gianlucca Gonçalves; Boechat, Ana Laura; de Almeida, Sandro Rogério; Baldini, Regina Lúcia

    2017-08-01

    Two-component systems are widespread in bacteria, allowing adaptation to environmental changes. The classical pathway is composed of a histidine kinase that phosphorylates an aspartate residue in the cognate response regulator (RR). RRs lacking the phosphorylatable aspartate also occur, but their function and contribution during host-pathogen interactions are poorly characterized. AtvR (PA14_26570) is the only atypical response regulator with a DNA-binding domain in the opportunistic pathogen Pseudomonas aeruginosa Macrophage infection with the atvR mutant strain resulted in higher levels of tumor necrosis factor alpha secretion as well as increased bacterial clearance compared to those for macrophages infected with the wild-type strain. In an acute pneumonia model, mice infected with the atvR mutant presented increased amounts of proinflammatory cytokines, increased neutrophil recruitment to the lungs, reductions in bacterial burdens, and higher survival rates in comparison with the findings for mice infected with the wild-type strain. Further, several genes involved in hypoxia/anoxia adaptation were upregulated upon atvR overexpression, as seen by high-throughput transcriptome sequencing (RNA-Seq) analysis. In addition, atvR was more expressed in hypoxia in the presence of nitrate and required for full expression of nitrate reductase genes, promoting bacterial growth under this condition. Thus, AtvR would be crucial for successful infection, aiding P. aeruginosa survival under conditions of low oxygen tension in the host. Taken together, our data demonstrate that the atypical response regulator AtvR is part of the repertoire of transcriptional regulators involved in the lifestyle switch from aerobic to anaerobic conditions. This finding increases the complexity of regulation of one of the central metabolic pathways that contributes to Pseudomonas ubiquity and versatility. Copyright © 2017 American Society for Microbiology.

  3. Azudas en Chile: un vernáculo sistema de riego en tierras de secano

    Directory of Open Access Journals (Sweden)

    José Marcelo Bravo Sánchez

    2013-01-01

    Full Text Available Expuesta a condiciones adversas, la creatividad humana se sobrepone. Una muestra de esta virtud es la aparición de las azudas o ruedas de agua en la actividad agrícola. Se trataba de dominar los ambientes áridos y semiáridos, consiguiendo un eficiente riego de los campos destinados al cultivo. En América, los ejemplos sobre el uso de ruedas de agua son más escasos. Existen como referencia de la implementación de azudas, en pleno valle central de Chile, en la Región de O’Higgins, donde han sido consideradas como una suerte de extensión de la arquitectura vernácula del poblado de Larmahue. Aun cuando han sido reconocidas en el ámbito nacional y el extranjero, han debido enfrentar desastres naturales, el desamparo legal y, lo que es peor, la falta de interés y recursos por mantenerlas.

  4. Vernácula modernidad: influencia de la arquitectura vernácula mediterránea en la aparición y desarrollo de la arquitectura moderna durante el primer tercio del siglo XX

    OpenAIRE

    Jiménez Vicario, Pedro Miguel

    2017-01-01

    [ESP] En la arquitectura vernácula encontramos una serie de valores y cualidades formales que no siempre fueron percibidos como tales. Su atemporalidad y lejanía de corrientes y estilos artísticos supuso que históricamente se percibiera como un elemento estable y prácticamente inmutable a lo largo del tiempo. Antaño ignorada, criticada y denostada después, ensalzada y alabada en el último siglo, el modo en que se ha percibido y los mecanismos mediante los cuales se ha dado a conocer en la cu...

  5. Tropes of Ascesis and Ascent in Polar Expeditions from Verne to Amundsen

    Directory of Open Access Journals (Sweden)

    Lucia Claudia Fiorella

    2011-04-01

    Full Text Available What we know of polar expeditions coincides with a number of fictional and non fictional representations using different registers: the iconic-technical-scientific, the auto/biographical, the literary/fictional. This paper draws a comparison between texts featuring contrasting views on the character and purposes of polar expeditions, their supposed usefulness and political consequences, and the certification procedures of scientific knowledge, reflecting broader concerns about the idea of progress, the man/environment relation, and international relations. Fictional and non fictional texts are involved in this ideological confrontation in varying degrees of urgency. However, one cannot fail to note ongoing competition between the two, if only for the fact that the explorers’ accounts take pains to produce hallmarks of authenticity, veridicality and reliability in order not to be mixed up with fiction; on the other hand, fiction makes use of mimetic strategies achieving an amazing effect of realism.The contributor offers a thematic reading of ascent-related tropes, focusing on Jules Verne’s Captain Hatteras (1866 as an example of critical optimism in contrast with the apocalyptic Purple Cloud (1901 by M.P. Shiel, as well as with R.E. Amundsen’s My Polar Flight (1925 – which features an optimism that has lost its Promethean overtones and comes closer to the elation for a sporting achievement.

  6. Simulation of permafrost and seasonal thaw depth in the JULES land surface scheme

    Directory of Open Access Journals (Sweden)

    R. Dankers

    2011-04-01

    Full Text Available Land surface models (LSMs need to be able to simulate realistically the dynamics of permafrost and frozen ground. In this paper we evaluate the performance of the LSM JULES (Joint UK Land Environment Simulator, the stand-alone version of the land surface scheme used in Hadley Centre climate models, in simulating the large-scale distribution of surface permafrost. In particular we look at how well the model is able to simulate the seasonal thaw depth or active layer thickness (ALT. We performed a number of experiments driven by observation-based climate datasets. Visually there is a very good agreement between areas with permafrost in JULES and known permafrost distribution in the Northern Hemisphere, and the model captures 97% of the area where the permafrost coverage is at least 50% of the grid cell. However, the model overestimates the total extent as it also simulates permafrost where it occurs sporadically or only in isolated patches. Consistent with this we find a cold bias in the simulated soil temperatures, especially in winter. However, when compared with observations on end-of-season thaw depth from around the Arctic, the ALT in JULES is generally too deep. Additional runs at three sites in Alaska demonstrate how uncertainties in the precipitation input affect the simulation of soil temperatures by affecting the thickness of the snowpack and therefore the thermal insulation in winter. In addition, changes in soil moisture content influence the thermodynamics of soil layers close to freezing. We also present results from three experiments in which the standard model setup was modified to improve physical realism of the simulations in permafrost regions. Extending the soil column to a depth of 60 m and adjusting the soil parameters for organic content had relatively little effect on the simulation of permafrost and ALT. A higher vertical resolution improves the simulation of ALT, although a considerable bias still remains. Future model

  7. Simulation of permafrost and seasonal thaw depth in the JULES land surface scheme

    Directory of Open Access Journals (Sweden)

    R. Dankers

    2011-09-01

    Full Text Available Land surface models (LSMs need to be able to simulate realistically the dynamics of permafrost and frozen ground. In this paper we evaluate the performance of the LSM JULES (Joint UK Land Environment Simulator, the stand-alone version of the land surface scheme used in Hadley Centre climate models, in simulating the large-scale distribution of surface permafrost. In particular we look at how well the model is able to simulate the seasonal thaw depth or active layer thickness (ALT. We performed a number of experiments driven by observation-based climate datasets. Visually there is a very good agreement between areas with permafrost in JULES and known permafrost distribution in the Northern Hemisphere, and the model captures 97% of the area where the spatial coverage of the permafrost is at least 50%. However, the model overestimates the total extent as it also simulates permafrost where it occurs sporadically or only in isolated patches. Consistent with this we find a cold bias in the simulated soil temperatures, especially in winter. However, when compared with observations on end-of-season thaw depth from around the Arctic, the ALT in JULES is generally too deep. Additional runs at three sites in Alaska demonstrate how uncertainties in the precipitation input affect the simulation of soil temperatures by affecting the thickness of the snowpack and therefore the thermal insulation in winter. In addition, changes in soil moisture content influence the thermodynamics of soil layers close to freezing. We also present results from three experiments in which the standard model setup was modified to improve physical realism of the simulations in permafrost regions. Extending the soil column to a depth of 60 m and adjusting the soil parameters for organic content had relatively little effect on the simulation of permafrost and ALT. A higher vertical resolution improves the simulation of ALT, although a considerable bias still remains. Future model

  8. Hipérbole ou parábola: a matemática e a ciência na obra de Júlio Verne

    OpenAIRE

    Mestrinho, Nelson

    2006-01-01

    Pretende-se com este texto fazer uma breve reflexão sobre o papel da ciência, com especial ênfase nas ciências matemáticas e físicas, na obra literária de Júlio Verne, mas também sobre a importância do seu trabalho na divulgação do conhecimento científico. Júlio Verne viveu numa época em que ocorreram grandes desenvolvimentos científicos que afectaram a vida quotidiana das pessoas comuns. Encarado no século XX como um profeta da modernidade, Verne foi também um divulgador da...

  9. Hipérbole ou parábola: a matemática e a ciência na obra de Júlio Verne

    OpenAIRE

    Mestrinho, Nelson

    2006-01-01

    Pretende-se com este texto fazer uma breve reflexão sobre o papel da ciência, com especial ênfase nas ciências matemáticas e físicas, na obra literária de Júlio Verne, mas também sobre a importância do seu trabalho na divulgação do conhecimento científico. Júlio Verne viveu numa época em que ocorreram grandes desenvolvimentos científicos que afectaram a vida quotidiana das pessoas comuns. Encarado no século XX como um profeta da modernidade, Verne foi também um divulgador da...

  10. Global evaluation of gross primary productivity in the JULES land surface model v3.4.1

    Directory of Open Access Journals (Sweden)

    D. Slevin

    2017-07-01

    Full Text Available This study evaluates the ability of the JULES land surface model (LSM to simulate gross primary productivity (GPP on regional and global scales for 2001–2010. Model simulations, performed at various spatial resolutions and driven with a variety of meteorological datasets (WFDEI-GPCC, WFDEI-CRU and PRINCETON, were compared to the MODIS GPP product, spatially gridded estimates of upscaled GPP from the FLUXNET network (FLUXNET-MTE and the CARDAMOM terrestrial carbon cycle analysis. Firstly, when JULES was driven with the WFDEI-GPCC dataset (at 0. 5° × 0. 5° spatial resolution, the annual average global GPP simulated by JULES for 2001–2010 was higher than the observation-based estimates (MODIS and FLUXNET-MTE, by 25 and 8 %, respectively, and CARDAMOM estimates by 23 %. JULES was able to simulate the standard deviation of monthly GPP fluxes compared to CARDAMOM and the observation-based estimates on global scales. Secondly, GPP simulated by JULES for various biomes (forests, grasslands and shrubs on global and regional scales were compared. Differences among JULES, MODIS, FLUXNET-MTE and CARDAMOM on global scales were due to differences in simulated GPP in the tropics. Thirdly, it was shown that spatial resolution (0. 5° × 0. 5°, 1° × 1° and 2° × 2° had little impact on simulated GPP on these large scales, with global GPP ranging from 140 to 142 PgC year−1. Finally, the sensitivity of JULES to meteorological driving data, a major source of model uncertainty, was examined. Estimates of annual average global GPP were higher when JULES was driven with the PRINCETON meteorological dataset than when driven with the WFDEI-GPCC dataset by 3 PgC year−1. On regional scales, differences between the two were observed, with the WFDEI-GPCC-driven model simulations estimating higher GPP in the tropics (5° N–5° S and the PRINCETON-driven model simulations estimating higher GPP in the extratropics (30

  11. Aproximações entre a obra de Júlio Verne e o ensino de física

    OpenAIRE

    Júlio César David Ferreira

    2011-01-01

    Buscamos uma aproximação entre dois campos do conhecimento que envolvem diferentes gêneros de linguagem: a literatura de ficção científica e a física. Partimos do pressuposto de que todo professor é professor de leitura, e como decorrência, todas as formas de leitura se relacionam e criam entre si pontos de apoio para a construção de sentidos. Assim, na obra de Júlio Verne, procuramos por elementos associados ao conteúdo de física do Ensino Médio. Nos livros Viagem ao Centro da Terra, Vinte M...

  12. Sources of interannual yield variability in JULES-crop and implications for forcing with seasonal weather forecasts

    Directory of Open Access Journals (Sweden)

    K. E. Williams

    2015-06-01

    Full Text Available JULES-crop is a parametrisation of crops in the Joint UK Land Environment Simulator (JULES. We investigate the sources of the interannual variability in the modelled maize yield, using global runs driven by reanalysis data, with a view to understanding the impact of various approximations in the driving data and initialisation. The standard forcing dataset for JULES consists of a combination of meteorological variables describing precipitation, radiation, temperature, pressure, specific humidity and wind, at subdaily time resolution. We find that the main characteristics of the modelled yield can be reproduced with a subset of these variables and using daily forcing, with internal disaggregation to the model timestep. This has implications in particular for the use of the model with seasonal forcing data, which may not have been provided at subdaily resolution for all required driving variables. We also investigate the effect on annual yield of initialising the model with climatology on the sowing date. This approximation has the potential to considerably simplify the use of the model with seasonal forecasts, since obtaining observations or reanalysis output for all the initialisation variables required by JULES for the start date of the seasonal forecast would present significant practical challenges.

  13. SALT spectroscopic classification of PS16atu (SN 2016atv) as a type-Ia supernova after maximum light

    Science.gov (United States)

    Jha, S. W.; Pan, Y.-C.; Foley, R. J.; Rest, A.; Scolnic, D.; Kotze, M.

    2016-03-01

    We obtained SALT (+RSS) spectroscopy of PS16atu (SN 2016atv) on 2016 Mar 10.1 UT, covering the wavelength range 350-920 nm. Cross-correlation of the spectrum with a template library using SNID (Blondin & Tonry 2007, ApJ, 666, 1024) shows PS16atu is a type-Ia supernova approximately a week past maximum light.

  14. Structural and genomic properties of the hyperthermophilic archaeal virus ATV with an extracellular stage of the reproductive cycle

    DEFF Research Database (Denmark)

    Prangishvili, David; Vestergaard, Gisle Alberg; Häring, Monika;

    2006-01-01

    A novel virus, ATV, of the hyperthermophilic archaeal genus Acidianus has the unique property of undergoing a major morphological development outside of, and independently of, the host cell. Virions are extruded from host cells as lemon-shaped tail-less particles, after which they develop long...

  15. Sugerencias para la ampliación y normalización de los nombres vernáculos de las plantas en lengua española

    OpenAIRE

    Mateo Sanz, Gonzalo

    2014-01-01

    Se aportan una serie de datos y reflexiones sobre la importancia de abordar la nominación de las plantas silvestres con nombres vernáculos en general y en concreto en el ámbito de la lengua española.

  16. Analysis of Steering Knuckle of All Terrain Vehicles (ATV) Using Finite Element Analysis

    Science.gov (United States)

    Dusane, S. V.; Dipke, M. K.; Kumbhalkar, M. A.

    2016-09-01

    Steering knuckle is the most stress sustaining and critical component of All Terrain Vehicle (ATV). Steering knuckle is the pivot point of the steering and suspension system, which allows the front wheels to turn and also allow the movement of suspension arms motion. The light weight and high strength component is always in demanding for racecar application. Lightweight and optimized design of steering knuckle is proposed to use for a BAJA SAE INDIA off road racecar. Due to the failure in knuckle in terrain vehicle after some instances, it has to be modified for better performance. The 3D CAD model created by using CATIA V5 and static as well as model analysis carried out in ANSYS 12 to understand its behavior under operating conditions. All test for frame was carried out on aluminum alloys 6061-T6 & for spindle EN8. The paper discusses the FE analysis of existing and modified Steering Knuckle.

  17. Jules Horowitz Reactor: Organisation for the Preparation of the Commissioning Phase and Normal Operation

    Energy Technology Data Exchange (ETDEWEB)

    Estrade, J.; Fabre, J. L.; Marcille, O. [French Alternative Energies end Atomic Energy Commission, Provence (France)

    2013-07-01

    The Jules Horowitz Reactor (JHR) is a new modern Material Testing Reactor (MTR) currently under construction at CEA Cadarache research centre in the south of France. It will be a major research facility in support to the development and the qualification of materials and fuels under irradiation with sizes and environment conditions relevant for nuclear power plants in order to optimise and demonstrate safe operations of existing power reactors as well as to support future reactors design. It will represent also an important research infrastructure for scientific studies dealing with material and fuel behaviour under irradiation. The JHR will contribute also to secure the production of radioisotope for medical application. This is a key public health stake. The construction of JHR which started in 2007 is going-on with target of commissioning by the end of 2017. The design of the reactor provides modern experimental capacity in support to R and D programs for the nuclear energy for the next 60 years. In parallel to the facility construction, the preparation of the future staff and of the organisation to operate the reactor safely, reliably and efficiently is an important issue. In this framework, many actions are in progress to elaborate: Ο the staffing and the organisational structure for the commissioning test phases and also for normal operation, Ο the documentation in support to the reactor operation (safety analysis report, general operating rules, procedures, instructions, ···), Ο the maintenance, in service and periodic test programs, Ο staff training programs by using dedicated facilities (simulator, ···) Ο commissioning test programs for ensuring that the layout of systems and subcomponents is completed in accordance with the design requirements, the specification performances and the safety criteria. These commissioning tests will also be helpful for transferring the knowledge on the installed systems to the operating group. This paper gives the

  18. The Missions of the United States Air Force in the 22nd Century

    Science.gov (United States)

    2009-04-01

    facility, rapidity and certainty as we now make the ocean voyage from Liverpool to New York. — Jules Verne , From the Earth to the Moon, 1865...space travel even though Jules Verne quite remarkably predicted the event 35 years earlier in From the Earth to the Moon. 3 The ―deadly...in the Next Hundred Years,‖ Ladies Home Journal, December 1900, 8. 3 Jules Verne describes manned spaceflight using a bullet-shaped capsule fired

  19. JPRS Report. Science & Technology: Europe.

    Science.gov (United States)

    1991-03-29

    represent a power of 3,200 kilowatt, the " Jules Verne " climatic wind tunnel can reproduce all the components of a given climate to evaluate a... Jules Verne wind tunnel meets the requirements of research and industry and numerous public and private contracts have already been entered into...CSTB. [Box] Performance of the Jules Verne Wind Tunnel (Stages 1 and 2) Top wind speed: 310 km/h (30 m2 section) Temperature range: from -25" C

  20. 四面楚歌--香港亚洲电视台(ATV)的生与死%Life and Death of Asian Television(ATV) in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    司若; 卓伯棠

    2005-01-01

    在数年来的香港电视市场上,一直存在着无线(TVB)与亚视(ATV)双雄争霸的局面.虽然在这个过程中,亚视曾几次占据上峰,但总体上不敌无线的强大实力.近年来,亚视改变经营理念,大批裁员,减少自制节目,大量外购节目,使亚视从一个自产自播的电视台逐渐转变为外购节目的播出平台,从而逐渐失去了原本的特色.这不仅使其在香港的收视率大幅度降低,而且广东的电视观众也越来越少地收看亚视节目.虽然亚视先于无线在广东获得了合法的落地权,但由于节目大部分为外购,只拥有香港的版权,所以难以在广东的广告分账中获得收益.从六七十年代两雄争霸的佳话发展到今天,亚视与无线的差距越来越大,已经到了必须进行改革的境地.

  1. Coupling between the JULES land-surface scheme and the CCATT-BRAMS atmospheric chemistry model (JULES-CCATT-BRAMS1.0: applications to numerical weather forecasting and the CO2 budget in South America

    Directory of Open Access Journals (Sweden)

    D. S. Moreira

    2013-08-01

    Full Text Available This article presents the coupling of the JULES surface model to the CCATT-BRAMS atmospheric chemistry model. This new numerical system is denominated JULES-CCATT-BRAMS. We demonstrate the performance of this new model system in relation to several meteorological variables and the CO2 mixing ratio over a large part of South America, focusing on the Amazon basin. The evaluation was conducted for two time periods, the wet (March and dry (September seasons of 2010. The model errors were calculated in relation to meteorological observations at conventional stations in airports and automatic stations. In addition, CO2 mixing ratios in the first model level were compared with meteorological tower measurements and vertical CO2 profiles were compared with observations obtained with airborne instruments. The results of this study show that the JULES-CCATT-BRAMS modeling system provided a significant gain in performance for the considered atmospheric fields relative to those simulated by the LEAF (version 3 surface model originally employed by CCATT-BRAMS. In addition, the new system significantly increases the ability to simulate processes involving air–surface interactions, due to the ability of JULES to simulate photosynthesis, respiration and dynamic vegetation, among other processes. We also discuss a wide range of numerical studies involving coupled atmospheric, land surface and chemistry processes that could be done with the system introduced here. Thus, this work presents to the scientific community a free modeling tool, with good performance in comparison with observational data and reanalysis model data, at least for the region and time period discussed here. Therefore, in principle, this model is able to produce atmospheric hindcast/forecast simulations at different spatial resolutions for any time period and any region of the globe.

  2. Love stories can be unpredictable: Jules et Jim in the vortex of life.

    Science.gov (United States)

    Dercole, Fabio; Rinaldi, Sergio

    2014-06-01

    Love stories are dynamic processes that begin, develop, and often stay for a relatively long time in a stationary or fluctuating regime, before possibly fading. Although they are, undoubtedly, the most important dynamic process in our life, they have only recently been cast in the formal frame of dynamical systems theory. In particular, why it is so difficult to predict the evolution of sentimental relationships continues to be largely unexplained. A common reason for this is that love stories reflect the turbulence of the surrounding social environment. But we can also imagine that the interplay of the characters involved contributes to make the story unpredictable-that is, chaotic. In other words, we conjecture that sentimental chaos can have a relevant endogenous origin. To support this intriguing conjecture, we mimic a real and well-documented love story with a mathematical model in which the environment is kept constant, and show that the model is chaotic. The case we analyze is the triangle described in Jules et Jim, an autobiographic novel by Henri-Pierre Roché that became famous worldwide after the success of the homonymous film directed by François Truffaut.

  3. Catálogo de los puentes proyectados por Jules Sagebien en la provincia de Matanzas.

    Directory of Open Access Journals (Sweden)

    Luis R. González Arestuche

    2014-01-01

    Full Text Available Esta investigación recopila en documento único, el mejor quehacer de uno de los principales forjadores de Matanzas como ciudad y del desarrollo industrial inicial, alcanzado en el siglo XIX, para la demarcación. El respeto hacia la conservación y el rescate del patrimonio construido en la actual provincia homónima, por sus altísimos valores: histórico, cultural y tecnológico, considera la necesidad del conocimiento ciudadano sobre la actividad del francés Jules Sagebien Tavernier. Desde el año 2009 diferentes instituciones y asociaciones promueven, desde Francia y aquí en Cuba, el estudio de sus realizaciones. Este trabajo pretende ir más allá de las observaciones anteriores, ya que los autores logran crear un catálogo, referido a la ingeniería de puentes desarrollada por él, que tuvo su máxima expresión en la propia ciudad de Matanzas y en los diferentes ramales ferroviarios que diseñó; obras todas ejecutadas en un tiempo que hoy parece imposible de alcanzar.

  4. Jules Tinel (1879-1952): Beyond the eponym, the man and his forgotten neurological contributions.

    Science.gov (United States)

    Walusinski, O

    2017-06-01

    The trauma of World War I had a lasting impact on clinician and physiologist Jules Tinel (1879-1952). His treatment of peripheral nervous system injuries led him, in 1917, to describe the eponymous sign that he linked to activity of the sympathetic nervous system. Among the sequelae of nerve injuries, he was confronted with causalgia that he attributed, here again, to the autonomic nervous system, the main focus of his laboratory research throughout his career. Tinel's sign became so well known that it eclipsed the originality of his seminal descriptions of exertional headache and of hypertensive emergency caused by pheochromocytoma, which could also have been associated with his name. He was always able to marry his clinical practice of neurology and psychiatric consultations with his anatomicopathological, physiological and pathophysiological research, which was based on his daily practice as a physician. At the same time, he directed the work of numerous assistants in his research laboratory, which has since been unjustly forgotten. Several hundreds of scientific publications, including three seminal works, bear witness to his intense activity, which he combined with a genuine talent for teaching and making his findings accessible to a wider public. Those publications alone would fully justify the historical value of extending his renown beyond the existing eponym. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. Radiation Transport Calculation of the UGXR Collimators for the Jules Horowitz Reactor (JHR)

    Science.gov (United States)

    Chento, Yelko; Hueso, César; Zamora, Imanol; Fabbri, Marco; Fuente, Cristina De La; Larringan, Asier

    2017-09-01

    Jules Horowitz Reactor (JHR), a major infrastructure of European interest in the fission domain, will be built and operated in the framework of an international cooperation, including the development and qualification of materials and nuclear fuel used in nuclear industry. For this purpose UGXR Collimators, two multi slit gamma and X-ray collimation mechatronic systems, will be installed at the JHR pool and at the Irradiated Components Storage pool. Expected amounts of radiation produced by the spent fuel and X-ray accelerator implies diverse aspects need to be verified to ensure adequate radiological zoning and personnel radiation protection. A computational methodology was devised to validate the Collimators design by means of coupling different engineering codes. In summary, several assessments were performed by means of MCNP5v1.60 to fulfil all the radiological requirements in Nominal scenario (TEDE < 25µSv/h) and in Maintenance scenario (TEDE < 2mSv/h) among others, detailing the methodology, hypotheses and assumptions employed.

  6. Jules Horowitz Reactor, a new irradiation facility: Improving dosimetry for the future of nuclear experimentation

    Energy Technology Data Exchange (ETDEWEB)

    Gregoire, G.; Beretz, D.; Destouches, C. [CEA, DEN, DER/SPEX, F-13108 Saint-Paul-lez-Durance (France)

    2011-07-01

    Document available in abstract form only, full text of document follows: The Jules Horowitz Reactor (JHR) is an experimental reactor under construction at the French Nuclear Energy and Alternative Energies Commission (CEA) facility at Cadarache. It will achieve its first criticality by the end of 2014. Experiments that will be conducted at JHR will deal with fuel, cladding, and material behavior. The JHR will also produce medical radio-isotopes and doped silicon for the electronic industry. As a new irradiation facility, its instrumentation will benefit from recent improvements. Nuclear instrumentation will include reactor dosimetry, as it is a reference technique to determine neutron fluence in experimental devices or characterize irradiation locations. Reactor dosimetry has been improved with the progress of simulation tools and nuclear data, but at the same time the customer needs have increased: Experimental results must have reduced and assessed uncertainties. This is now a necessary condition to perform an experimental irradiation in a test reactor. Items improved, in the framework of a general upgrading of the dosimetry process based on uncertainty minimization, will include dosimeter, nuclear data, and modelling scheme. (authors)

  7. Love stories can be unpredictable: Jules et Jim in the vortex of life

    Science.gov (United States)

    Dercole, Fabio; Rinaldi, Sergio

    2014-06-01

    Love stories are dynamic processes that begin, develop, and often stay for a relatively long time in a stationary or fluctuating regime, before possibly fading. Although they are, undoubtedly, the most important dynamic process in our life, they have only recently been cast in the formal frame of dynamical systems theory. In particular, why it is so difficult to predict the evolution of sentimental relationships continues to be largely unexplained. A common reason for this is that love stories reflect the turbulence of the surrounding social environment. But we can also imagine that the interplay of the characters involved contributes to make the story unpredictable—that is, chaotic. In other words, we conjecture that sentimental chaos can have a relevant endogenous origin. To support this intriguing conjecture, we mimic a real and well-documented love story with a mathematical model in which the environment is kept constant, and show that the model is chaotic. The case we analyze is the triangle described in Jules et Jim, an autobiographic novel by Henri-Pierre Roché that became famous worldwide after the success of the homonymous film directed by François Truffaut.

  8. Radiation Transport Calculation of the UGXR Collimators for the Jules Horowitz Reactor (JHR

    Directory of Open Access Journals (Sweden)

    Chento Yelko

    2017-01-01

    Full Text Available Jules Horowitz Reactor (JHR, a major infrastructure of European interest in the fission domain, will be built and operated in the framework of an international cooperation, including the development and qualification of materials and nuclear fuel used in nuclear industry. For this purpose UGXR Collimators, two multi slit gamma and X-ray collimation mechatronic systems, will be installed at the JHR pool and at the Irradiated Components Storage pool. Expected amounts of radiation produced by the spent fuel and X-ray accelerator implies diverse aspects need to be verified to ensure adequate radiological zoning and personnel radiation protection. A computational methodology was devised to validate the Collimators design by means of coupling different engineering codes. In summary, several assessments were performed by means of MCNP5v1.60 to fulfil all the radiological requirements in Nominal scenario (TEDE < 25µSv/h and in Maintenance scenario (TEDE < 2mSv/h among others, detailing the methodology, hypotheses and assumptions employed.

  9. Traducción de la Constitución colombiana de 1991 a siete Lenguas Vernáculas

    Directory of Open Access Journals (Sweden)

    Sandra Liliana Oróstegui Durán

    2008-01-01

    Full Text Available "El libro del árbol de alimento para la vida" es lo que significa para uno de los pueblos indígenas la palabra Constitución. Y es bajo este espíritu que se gestó el proyecto constitucional de 1991, en un momento en que Colombia, más que nunca, pedía por la vida. La Constitución del 91 logró reunir, para su redacción, a muchos sectores que componen el orden social del país, entre ellos dos representantes de grupos indígenas. Una vez el texto aprobado, la Presidencia de la República quiso hacer efectivo uno de sus artículos en los cuales se declara a Colombia como un país pluriétnico, plurilingüe y multicultural. El trabajo de traducción a siete lenguas vernáculas es prueba de ello. El presente texto tiene como fin mostrar las implicaciones sociales, políticas y culturales de ese trabajo.

  10. Coupling between the JULES land-surface scheme and the CCATT-BRAMS atmospheric chemistry model (JULES-CCATT-BRAMS1.0): applications to numerical weather forecasting and the CO2 budget in South America

    Science.gov (United States)

    Moreira, D. S.; Freitas, S. R.; Bonatti, J. P.; Mercado, L. M.; Rosário, N. M. É.; Longo, K. M.; Miller, J. B.; Gloor, M.; Gatti, L. V.

    2013-01-01

    This article presents the development of a new numerical system denominated JULES-CCATT-BRAMS, which resulted from the coupling of the JULES surface model to the CCATT-BRAMS atmospheric chemistry model. The performance of this system in relation to several meteorological variables (wind speed at 10 m, air temperature at 2 m, dew point temperature at 2 m, pressure reduced to mean sea level and 6 h accumulated precipitation) and the CO2 concentration above an extensive area of South America is also presented, focusing on the Amazon basin. The evaluations were conducted for two periods, the wet (March) and dry (September) seasons of 2010. The statistics used to perform the evaluation included bias (BIAS) and root mean squared error (RMSE). The errors were calculated in relation to observations at conventional stations in airports and automatic stations. In addition, CO2 concentrations in the first model level were compared with meteorological tower measurements and vertical CO2 profiles were compared with aircraft data. The results of this study show that the JULES model coupled to CCATT-BRAMS provided a significant gain in performance in the evaluated atmospheric fields relative to those simulated by the LEAF (version 3) surface model originally utilized by CCATT-BRAMS. Simulations of CO2 concentrations in Amazonia and a comparison with observations are also discussed and show that the system presents a gain in performance relative to previous studies. Finally, we discuss a wide range of numerical studies integrating coupled atmospheric, land surface and chemistry processes that could be produced with the system described here. Therefore, this work presents to the scientific community a free tool, with good performance in relation to the observed data and re-analyses, able to produce atmospheric simulations/forecasts at different resolutions, for any period of time and in any region of the globe.

  11. Coupling between the JULES land-surface scheme and the CCATT-BRAMS atmospheric chemistry model (JULES-CCATT-BRAMS1.0: applications to numerical weather forecasting and the CO2 budget in South America

    Directory of Open Access Journals (Sweden)

    D. S. Moreira

    2013-01-01

    Full Text Available This article presents the development of a new numerical system denominated JULES-CCATT-BRAMS, which resulted from the coupling of the JULES surface model to the CCATT-BRAMS atmospheric chemistry model. The performance of this system in relation to several meteorological variables (wind speed at 10 m, air temperature at 2 m, dew point temperature at 2 m, pressure reduced to mean sea level and 6 h accumulated precipitation and the CO2 concentration above an extensive area of South America is also presented, focusing on the Amazon basin. The evaluations were conducted for two periods, the wet (March and dry (September seasons of 2010. The statistics used to perform the evaluation included bias (BIAS and root mean squared error (RMSE. The errors were calculated in relation to observations at conventional stations in airports and automatic stations. In addition, CO2 concentrations in the first model level were compared with meteorological tower measurements and vertical CO2 profiles were compared with aircraft data. The results of this study show that the JULES model coupled to CCATT-BRAMS provided a significant gain in performance in the evaluated atmospheric fields relative to those simulated by the LEAF (version 3 surface model originally utilized by CCATT-BRAMS. Simulations of CO2 concentrations in Amazonia and a comparison with observations are also discussed and show that the system presents a gain in performance relative to previous studies. Finally, we discuss a wide range of numerical studies integrating coupled atmospheric, land surface and chemistry processes that could be produced with the system described here. Therefore, this work presents to the scientific community a free tool, with good performance in relation to the observed data and re-analyses, able to produce atmospheric simulations/forecasts at different resolutions, for any period of time and in any region of the globe.

  12. Evaluation of the JULES land surface model in simulating catchment hydrology in Southern Africa

    Directory of Open Access Journals (Sweden)

    N. C. MacKellar

    2013-08-01

    Full Text Available Land surface models (LSMs are advanced tools which can be used to estimate energy, water and biogeochemical exchanges at regional scales. The inclusion of a river flow routing module in an LSM allows for the simulation of river discharge from a catchment and offers an approach to evaluate the response of the system to variations in climate and land-use, which can provide useful information for regional water resource management. This study offers insight into some of the pragmatic considerations of applying an LSM over a regional domain in Southern Africa. The objectives are to identify key parameter sensitivities and investigate differences between two runoff production schemes in physically contrasted catchments. The Joint UK Land Environment Simulator (JULES LSM was configured for a domain covering Southern Africa at a 0.5° resolution. The model was forced with meteorological input from the WATCH Forcing Data for the period 1981–2001 and sensitivity to various model configurations and parameter settings were tested. Both the PDM and TOPMODEL sub-grid scale runoff generation schemes were tested for parameter sensitivities, with the evaluation focussing on simulated river discharge in sub-catchments of the Orange, Okavango and Zambezi rivers. It was found that three catchments respond differently to the model configurations and there is no single runoff parameterization scheme or parameter values that yield optimal results across all catchments. The PDM scheme performs well in the upper Orange catchment, but poorly in the Okavango and Zambezi, whereas TOPMODEL grossly underestimates discharge in the upper Orange and shows marked improvement over PDM for the Okavango and Zambezi. A major shortcoming of PDM is that it does not realistically represent subsurface runoff in the deep, porous soils typical of the Okavango and Zambezi headwaters. The dry-season discharge in these catchments is therefore not replicated by PDM. TOPMODEL, however

  13. The Jules Horowitz reactor (JHR), a European material testing reactor (MTR), with extended experimental capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P. [CEA Cadarache, Dir. de l' Energie Nucleaire DEN, 13 - Saint-Paul-lez-Durance (France)]|[CEA Saclay Dir. de l' Energie Nucleaire DEN, 91 - Gif sur Yvette (France)

    2003-07-01

    The Jules Horowitz Reactor (JHR) is the European MTR (Material Testing Reactor) designed to provide, after 2010, the necessary knowledge for keeping the existing power plants in operation and to design innovative reactors types with new objectives such as: minimizing the radioactive waste production, taking into account additional safety requirements, preventing risks of nuclear proliferation... To achieve such an ambitious objective. The JHR is designed with a high flexibility in order to satisfy the current demand from European industry, research and to be able to accommodate future requirements. The JHR will offer a wide range of performances and services in gathering, in a single site at Cadarache, all the necessary functionalities and facilities for an effective production of results: e.g. fuel fabrication laboratories, preparation of the instrumented devices, interpretation of the experiments, modelling. The JHR must rely on a top level scientific environment based on experts teams from CEA and EC and local universities. With a thermal flux of 7,4.10{sup 14} ncm{sup -2} s{sup -1} and a fast flux of 6,4.10{sup 14} ncm{sup -2}s{sup -1}, it is possible to carry out irradiation experiments on materials and fuels whatever the reactor type considered. It will also be possible to carry out locally, fast neutron irradiation to achieve damage effect up to 25 dpa/year. (dpa = displacement per atom.) The study of the fuels behavior under accidental conditions, from analytical experiments, on a limited amount of irradiated fuel, is a major objective of the project. These oriented safety tests are possible by taking into account specific requirements in the design of the facility such as the tightness level of the containment building, the addition of an alpha hot cell and a laboratory for on line fission products measurement. (authors)

  14. The Jules Horowitz reactor (JHR), a European material testing reactor (MTR), with extended experimental capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P. [CEA Cadarache, Dir. de l' Energie Nucleaire DEN, 13 - Saint-Paul-lez-Durance (France)]|[CEA Saclay Dir. de l' Energie Nucleaire DEN, 91 - Gif sur Yvette (France)

    2003-07-01

    The Jules Horowitz Reactor (JHR) is the European MTR (Material Testing Reactor) designed to provide, after 2010, the necessary knowledge for keeping the existing power plants in operation and to design innovative reactors types with new objectives such as: minimizing the radioactive waste production, taking into account additional safety requirements, preventing risks of nuclear proliferation... To achieve such an ambitious objective. The JHR is designed with a high flexibility in order to satisfy the current demand from European industry, research and to be able to accommodate future requirements. The JHR will offer a wide range of performances and services in gathering, in a single site at Cadarache, all the necessary functionalities and facilities for an effective production of results: e.g. fuel fabrication laboratories, preparation of the instrumented devices, interpretation of the experiments, modelling. The JHR must rely on a top level scientific environment based on experts teams from CEA and EC and local universities. With a thermal flux of 7,4.10{sup 14} ncm{sup -2} s{sup -1} and a fast flux of 6,4.10{sup 14} ncm{sup -2}s{sup -1}, it is possible to carry out irradiation experiments on materials and fuels whatever the reactor type considered. It will also be possible to carry out locally, fast neutron irradiation to achieve damage effect up to 25 dpa/year. (dpa = displacement per atom.) The study of the fuels behavior under accidental conditions, from analytical experiments, on a limited amount of irradiated fuel, is a major objective of the project. These oriented safety tests are possible by taking into account specific requirements in the design of the facility such as the tightness level of the containment building, the addition of an alpha hot cell and a laboratory for on line fission products measurement. (authors)

  15. America’s Energy Security Policy: Goals for 2025

    Science.gov (United States)

    2007-02-01

    vehicles. The promise of hydrogen technology is too great to ignore. In his 1874 novel, The Mysterious Island, Jules Verne described a world in...The Reference Shelf, Energy Policy, volume 74, Number 2 (H. W. Wilson, February 2002), 3-4. 75 Jules Verne , The Mysterious Island, 1874, original

  16. USSR Report, Space, No. 19.

    Science.gov (United States)

    1983-01-31

    for correcting the trajectory and deceleration upon land- ing ( Jules Verne "De la Terre ä la Lune", 1870), on an artificial earth satel- lite used...is set forth by Jules Verne in "Five Hundred Million Begums" (1879). Finally, the novelist’s fantasy uses a jet engine operating on nuclear energy

  17. Safe Ride Standards for Casualty Evacuation Using Unmanned Aerial Vehicles (Normes de transport sans danger pour l’evacuation des blesses par vehicules aeriens sans pilote)

    Science.gov (United States)

    2012-12-01

    type of limited in-flight care. Unfortunately, this forward-looking concept, which gained him the sobriquet of “the Jules Verne of aviation medicine... Jules Verne Van Den Gezondheids-Luchtdienst”. ANNEX B – HISTORY AND DEVELOPMENT OF AERIAL EVACUATION, WITH SPECIFIC REFERENCE TO UAV POTENTIAL USE

  18. Developing and Populating the Global Information Grid for Joint and Coalition Operations: Challenges and Opportunities

    Science.gov (United States)

    2004-06-01

    SPRINGFIELD (SSN) NON-OEF TASKING FS AIGLE (MHC) FS DAGUE (LCT) FS D’ENTRECASTEAUX (AGS) FS FLOREAL (FFG) FS ISARD (AG) FS JULES VERNE (AD) FS LA...ISARD (AG) FS JULES VERNE (AD) FS LA LAVALLEE (FFG) FS LOIRE (AG) FS SIROCO (LSD) FS VAR (AOR) FS VERSEAU (MHC) HMS SPLENDID (SSN) INPORT MUSCAT RBNS

  19. Main technical options of the Jules Horowitz reactor project to achieve high flux performances and high safety level

    Energy Technology Data Exchange (ETDEWEB)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P. [CEA Cadarache, Dir. de l' Energie Nucleaire DEN, 13 - Saint-Paul-lez-Durance (France)]|[CEA Saclay Dir. de l' Energie Nucleaire DEN, 91 - Gif sur Yvette (France)

    2003-07-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it and will offer a quite larger experimental field. It has the ambition to provide the necessary nuclear data and to maintain a fission research capability in Europe after 2010. The Jules Horowitz Reactor will represent a significant step in terms of performances and experimental capabilities. This paper will present the main design option resulting from the preliminary studies. The choice of the specific power around 600 kW/I for the reference core configuration is a key decision to ensure the required flux level. Consequently many choices have to be made regarding the materials used in the core and the fuel element design. These involve many specific qualifications including codes validation. The main safety options are based on: - A safety approach based upon the defence-in-depth principle. - A strategy of generic approaches to assess experimental risks in the facility. - Internal events analysis taking into account risks linked to reactor and experiments (e.g., radioactive source-term). - Systematic consideration of external hazards (e.g., earthquake, airplane crash) and internal hazards. - Design of containment to manage and mitigate a severe reactor accident (consideration of 'BORAX' accident, according to french safety practice for MTRs, beyond design basis reactivity insertion accident, involving core melting and core destruction phenomena). (authors)

  20. ¿Traducir o recrear ? El dilema de los adaptadores teatrales hispánicos en el caso de Julio Verne

    OpenAIRE

    Figuerola Cabrol, M. Carme

    2013-01-01

    Como en el caso de muchos otros países Julio Verne ha sido un autor de éxito en España, hasta el punto de ser considerado por sus contemporáneos como el autor francés más célebre. Nuestro análisis pretende observar la repercusión que tuvo su obra Miguel Strogoff especialmente en el mundo de las tablas: el contenido divulgativo geográfico, la abundancia de fragmentos protagonizados por multitudes de personajes suponen retos importantes para los adaptadores cuyas soluciones atestiguan a menudo ...

  1. Improved representation of plant functional types and physiology in the Joint UK Land Environment Simulator (JULES v4.2) using plant trait information

    NARCIS (Netherlands)

    Harper, Anna B.; Cox, Peter M.; Friedlingstein, Pierre; Wiltshire, Andy J.; Jones, Chris D.; Sitch, Stephen; Mercado, Lina M.; Groenendijk, Margriet; Robertson, Eddy; Kattge, Jens; Bönisch, Gerhard; Atkin, Owen K.; Bahn, Michael; Cornelissen, Johannes; Niinemets, Ülo; Onipchenko, Vladimir; Peñuelas, Josep; Poorter, Lourens; Reich, Peter B.; Soudzilovskaia, Nadjeda A.; Bodegom, van Peter

    2016-01-01

    Dynamic global vegetation models are used to predict the response of vegetation to climate change. They are essential for planning ecosystem management, understanding carbon cycle-climate feedbacks, and evaluating the potential impacts of climate change on global ecosystems. JULES (the Joint UK

  2. Improved representation of plant functional types and physiology in the Joint UK Land Environment Simulator (JULES v4.2) using plant trait information

    NARCIS (Netherlands)

    Harper, Anna B.; Cox, Peter M.; Friedlingstein, Pierre; Wiltshire, Andy J.; Jones, Chris D.; Sitch, Stephen; Mercado, Lina M.; Groenendijk, Margriet; Robertson, Eddy; Kattge, Jens; Bönisch, Gerhard; Atkin, Owen K.; Bahn, Michael; Cornelissen, Johannes; Niinemets, Ülo; Onipchenko, Vladimir; Peñuelas, Josep; Poorter, Lourens; Reich, Peter B.; Soudzilovskaia, Nadjeda A.; Bodegom, van Peter

    2016-01-01

    Dynamic global vegetation models are used to predict the response of vegetation to climate change. They are essential for planning ecosystem management, understanding carbon cycle-climate feedbacks, and evaluating the potential impacts of climate change on global ecosystems. JULES (the Joint UK L

  3. Kinetics of hydrogen absorption and desorption of a mechanically milled MgH2+5at%V nanocomposite

    Institute of Scientific and Technical Information of China (English)

    Qian Li; Kuangdi Xu; Kuochih Chou; Xionggang Lu; Qin Lin

    2006-01-01

    The experimental data in the MgH2-5at%V composite was summarized and used to investigate the kinetic mechanism of hydrogen absorption and desorption using a new model. The research results indicate that a coincidence of the theoretical calculation values with the experimental data has been reached and the rate-limiting step is hydrogen diffusion through the hydride phase (β phase)with the activation energy of 47.2 kJ per mole H2 for absorption and the diffusion of hydrogen in the α solid solution (α phase) with that of 59.1 kJ per mole H2 for desorption. In addition, the hydriding rate of the MgH2-V composite is 2.9 times faster than that of MgH2powders when compared with their characteristic absorption time directly.

  4. ANITA: The European Technology Demonstrator for Trace Gas Monitoring in the International Space Station Atmosphere

    Science.gov (United States)

    Tan, Gijsbert; Mosebach, Herbert; Honne, Atle

    2005-12-01

    The accumulation of toxic or otherwise harmful trace gases in a spacecraft cabin is a very serious concern in terms of health and safety of the crew. Much progress has been made in developing techniques for monitoring the air quality on board and in near-real-time. The technique developed in Europe has reached the state of an in-flight technology demonstrator. ANITA (Analysing Interferometer for Ambient Air) is based on FTIR (Fourier Transform Infra-Red) Spectrometry. ANITA is calibrated to identify and quantify quasi online more than 30 contaminants at low ppm (part per million) or sub-ppm detection limits.ANITA is a European Space Agency (ESA) - National Aeronautics and Space Administration (NASA) cooperative programme.ANITA will be launched with Jules Verne, the maiden flight of the Automatic Transfer Vehicle (ATV) currently scheduled for June 2007.

  5. The flight experiment ANITA—a high performance air analyser for manned space cabins

    Science.gov (United States)

    Stuffler, T.; Mosebach, H.; Kampf, D.; Honne, A.; Tan, G.

    2004-08-01

    Analysing Interferometer for Ambient Air (ANITA) is a flight experiment as precursor for a permanent continuous trace gas monitoring system on the International Space Station (ISS). For over 10 years, under various ESA contracts the flight experiment was defined, designed, breadboarded and set up. For the safety of the crew, ANITA can detect and quantify quasi on-line and simultaneously 32 trace gases with ppm or sub-ppm detection limits. The self-standing measurement system is based on Fourier Transform Infrared Spectrometer (FTIR) technology. The system represents a versatile air monitor allowing for the first time the detection and monitoring of trace gas dynamics of a spacecraft atmosphere. It is envisaged to accommodate ANITA in a Destiny (US LAB) Express Rack on the ISS. The transportation to the ISS is planned with the first ATV 'Jules Verne'. The options are either the Space Shuttle or the Automated Transfer Vehicle.

  6. The flight experiment ANITA--a high performance air analyser for manned space cabins.

    Science.gov (United States)

    Stuffler, T; Mosebach, H; Kampf, D; Honne, A; Tan, G

    2004-01-01

    Analysing Interferometer for Ambient Air (ANITA) is a flight experiment as precursor for a permanent continuous trace gas monitoring system on the International Space Station (ISS). For over 10 years, under various ESA contracts the flight experiment was defined, designed, breadboarded and set up. For the safety of the crew, ANITA can detect and quantify quasi on-line and simultaneously 32 trace gases with ppm or sub-ppm detection limits. The self-standing measurement system is based on Fourier Transform Infrared Spectrometer (FTIR) technology. The system represents a versatile air monitor allowing for the first time the detection and monitoring of trace gas dynamics of a spacecraft atmosphere. It is envisaged to accommodate ANITA in a Destiny (US LAB) Express Rack on the ISS. The transportation to the ISS is planned with the first ATV 'Jules Verne'. The options are either the Space Shuttle or the Automated Transfer Vehicle. c2004 Elsevier Ltd. All rights reserved.

  7. Corrosion of the AlFeNi alloy used for the fuel cladding in the Jules Horowitz research reactor

    Science.gov (United States)

    Wintergerst, M.; Dacheux, N.; Datcharry, F.; Herms, E.; Kapusta, B.

    2009-09-01

    The AlFeNi aluminium alloy (1 wt% Fe, 1 wt% Ni, 1 wt% Mg) is expected to be used as nuclear fuel cladding for the Jules Horowitz experimental reactor. To guarantee a safe behaviour of the fuel, a good understanding of the fuel clad corrosion mechanisms is required. In this field, the experimental characterization of the selected alloy was performed. Then experimental studies of the aluminium alloy corrosion product obtained in autoclaves have shown an oxide film composed of two layers. This duplex structure results from a mixed growth mechanism: an anionic growth to develop the inner oxide and a cationic diffusion parallel to a dissolution-precipitation process to form the outer zone. Dynamic experiments at 70 °C have demonstrated that a solid diffusion step controls the release kinetic. Then post-irradiation exams performed on irradiated fuel plates were used to investigate the effects of the irradiation on the corrosion behaviour in the reactor core.

  8. Emission and transmission tomography systems to be developed for the future needs of Jules Horowitz material testing reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kotiluoto, Petri [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland)], E-mail: petri.kotiluoto@vtt.fi; Wasastjerna, Frej; Kekki, Tommi [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland); Sipilae, Heikki; Banzuzi, Kukka [Oxford Instruments Analytical Oy, Nihtisillankuja 5, P.O.Box 85, FI-02631 Espoo (Finland); Kinnunen, Petri; Heikinheimo, Liisa [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland)

    2009-08-01

    The new 100 MW Jules Horowitz material testing reactor will be built in Cadarache, France. It will support, for instance, research on new types of innovative nuclear fuel. As a Finnish in-kind contribution, 3D emission and transmission tomography equipment will be delivered for both the reactor and the active component storage pool. The image reconstruction of activities inside the used nuclear fuel will be based on gamma spectrometry measurements. A new type of underwater digital X-ray linear detector array is under development for transmission imaging, based on GaAs and direct conversion of X-rays into an electrical signal. A shared collimator will be used for both emission and transmission measurements. Some preliminary design has been performed. For the current design, the expected gamma spectrometric response of a typical high-purity germanium detector has been simulated with MCNP for minimum and maximum source activities (specified by CEA) to be measured in future.

  9. Sensitivity Analysis and Parameter Identifiability of the Land Surface Model JULES at the point scale in permeable catchments

    Science.gov (United States)

    Bakopoulou, C.; Bulygina, N.; Butler, A. P.; McIntyre, N. R.

    2012-04-01

    Land surface models (LSMs) are recognised as important components of Global Circulation Models (GCMs). Simulating exchanges of the moisture, carbon and energy between land surface and atmosphere in a consistent manner requires physics-based LSMs of high complexity, fine vertical resolution and a large number of parameters that need to be estimated. The "physics" that is incorporated in such models is generally based on our knowledge of point (or very small) scale hydrological processes. Therefore, while larger GCM grid-scale performance may be the ultimate goal, the ability of the model to simulate the point-scale processes is, intuitively, a pre-requisite for its reliable use at larger scales. Critical evaluation of model performance and parameter uncertainty at point scales is therefore a rational starting point for critical evaluation of LSMs; and identification of optimal parameter sets at the point scale is a significant stage of the model evaluation at larger scales. The Joint UK Land Environment Simulator (JULES) is a complex LSM, which is used to represent surface exchanges in the UK Met Office's forecast and climate change models. This complexity necessitates a large number of model parameters (in total 108) some of which are incapable of being measured directly at large (i.e. kilometer) scales. For this reason, a parameter sensitivity analysis is a vital confidence building process within the framework of every LSM, and as a part of the calibration strategy. The problem of JULES parameter estimation and uncertainty at the point scale with a view to assessing the accuracy and the uncertainty in the default parameter values is addressed. The sensitivity of the JULES output of soil moisture is examined using parameter response surface analysis. The implemented technique is based on the Regional Sensitivity Analysis method (RSA), which evaluates the model response surface over a region of parameter space using Monte Carlo sampling. The modified version of RSA

  10. [The amazing career of a homeopath, philanthropist, Fourierist, Benoît-Jules Mure. (1809-1858)].

    Science.gov (United States)

    Ségal, Alain; Trépardoux, Francis

    2005-01-01

    The authors evoke the difficulty of dealing with the life and work of Benoît-Jules Mure who was a homeopathic scientist and a keen specialist on propaganda. He was also an adept of Charles Fourier and he used almost his fortune to the spreading of homeopathy and at time, the improvement of social life. Thus he tried to settle humanitarian colonies in Brazil and later in Egypt, Nubian and Sudan in order to improve their fashion of life. He was hit by tuberculosis which led him discover homeopathy and by his strength of character lie led the idea of his mission in favour of his convictions. He was very angry with the official medical organisation and at last he never has been recognized as a médical doctor. The authors underline that his life and his work have probably left some definite marks in the South America let alone the birth of Socialism.

  11. Crystal structure of ATVORF273, a new fold for a thermo- and acido-stable protein from the Acidianus two-tailed virus

    DEFF Research Database (Denmark)

    Felisberto-Rodrigues, Catarina; Blangy, Stéphanie; Goulet, Adeline;

    2012-01-01

    in the viral world. To understand this intriguing phenomenon, we have undertaken structural studies of ATV virion proteins and here we present the crystal structure of one of these proteins, ATV[Formula: see text]. ATV[Formula: see text] forms tetramers in solution and a molecular envelope is provided...... for the tetramer, computed from small-angle X-ray scattering (SAXS) data. The crystal structure has properties typical of hyperthermostable proteins, including a relatively high number of salt bridges. However, the protein also exhibits flexible loops and surface pockets. Remarkably, ATV[Formula: see text......] displays a new [Formula: see text] protein fold, consistent with the absence of homologues of this protein in public sequence databases....

  12. The GNC Measurement System for the Automated Transfer Vehicle

    Science.gov (United States)

    Roux, Y.; da Cunha, P.

    The Automated Transfer Vehicle (ATV) is a European Space Agency (ESA) funded spacecraft developed by EADS Space Transportation as prime contractor for the space segment together with major European industrial partners, in the frame of the International Space Station (ISS). Its mission objective is threefold : to supply the station with fret and propellant, to reboost ISS to a higher orbit and to dispose of waste from the station. The ATV first flight, called Jules Verne and planned on 2005, will be the first European Vehicle to perform an orbital rendezvous. The GNC Measurement System (GMS) is the ATV on board function in charge of the measurement data collection and preconditioning for the navigation, guidance and control (GNC) algorithms. The GMS is made up of hardware which are the navigation sensors (with a certain level of hardware redundancy for each of them), and of an on-board software that manages, monitors and performs consistency checks to detect and isolate potential sensor failures. The GMS relies on six kinds of navigation sensors, used during various phases of the mission : the gyrometers assembly (GYRA), the accelerometers assembly (ACCA), the star trackers (STR), the GPS receivers, the telegoniometers (TGM) and the videometers (VDM), the last two being used for the final rendezvous phase. The GMS function is developed by EADS Space Transportation together with other industrial partners: EADS Astrium, EADS Sodern, Laben and Dasa Jena Optronik.

  13. Patrones de transfiguración de la vivienda vernácula. Caso de estudio: Chilapa de Álvarez (Guerrero, México

    Directory of Open Access Journals (Sweden)

    Osvaldo Ascencio López

    2014-10-01

    Full Text Available Desde la segunda mitad del siglo XX, en México, se ha presentado un crecimiento acelerado de las ciudades y una reducción importante de la población rural producto de la migración a los principales centros urbanos. Esto ha generado fenómenos de interacción entre las ciudades y el campo; uno de ellos, el proceso de rururbanización, que trae, dentro de sus consecuencias, la modificación de patrones de edificación. Este artículo, resultado de una investigación, plantea la transformación de la vivienda vernácula por influencia de la rururbanización, la cual deriva en una transfiguración que tiene como característica no solo la evolución del espacio físico, sino también una nueva concepción del hábitat originado en el cambio generacional, social y de actividades económicas. En este contexto, la investigación identificó los patrones de edificación de la vivienda vernácula que se habían mantenido con pocos cambios hasta hace una décadas, y, hoy en día, se han detectado modificaciones a la estructura original de la vivienda por una nueva percepción del hábitat, una nueva habitabilidad.

  14. La "Carta a los maestros" de Jules Ferry (1883 y el laicismo escolar de la IIIª República francesa

    Directory of Open Access Journals (Sweden)

    Juan Manuel FERNÁNDEZ SORIA

    2010-03-01

    Full Text Available RESUMEN: Partiendo del valor histórico —de lo que es una muestra su influencia en la política educativa de la Segunda República española— y de la proyección de su legado en nuestros días de la «Carta a los Maestros» (1883 del ministro francés de Instrucción Pública, Jules Ferry, este trabajo se acerca a la vida de su autor y a su política educativa para analizar luego con mayor profundidad los aspectos más sobresalientes del documento —que transcribimos en francés y castellano—, especialmente el laicismo escolar, como medio de establecer una escuela nacional y de fundación de la República, la defensa de la moral común y positiva, los modos y procedimientos —tanto directos como indirectos— de su enseñanza, así como el papel del maestro y del manual en la educación moral y cívica del futuro ciudadano. ABSTRACT: Starting with the historic value —of which it is an example its influence in the educational policy of the Second Republic— and with the influence that remains in our days, of the legate of the «Elementary Schoolteacher’s Letter», written by Jules Ferry, French minister of the Public Instruction, this piece of work approaches to its author’s life and to its educational policy in order to analyse later in greater detail the most relevant aspects of the document —which we reproduce in Spanish and French— specially the scholastic laicism as a way to establish a national school, and the foundation of the Republic, the defence of common and positive morality, the ways and procedures, both direct and indirect, of its teaching, and also the role of schoolteachers and the guide in the moral and civic education of the future citizens.

  15. Further evaluation of wetland emission estimates from the JULES land surface model using SCIAMACHY and GOSAT atmospheric column methane measurements

    Science.gov (United States)

    Hayman, Garry; Comyn-Platt, Edward; McNorton, Joey; Chipperfield, Martyn; Gedney, Nicola

    2016-04-01

    The atmospheric concentration of methane began rising again in 2007 after a period of near-zero growth [1,2], with the largest increases observed over polar northern latitudes and the Southern Hemisphere in 2007 and in the tropics since then. The observed inter-annual variability in atmospheric methane concentrations and the associated changes in growth rates have variously been attributed to changes in different methane sources and sinks [2,3]. Wetlands are generally accepted as being the largest, but least well quantified, single natural source of CH4, with global emission estimates ranging from 142-284 Tg yr-1 [3]. The modelling of wetlands and their associated emissions of CH4 has become the subject of much current interest [4]. We have previously used the HadGEM2 chemistry-climate model to evaluate the wetland emission estimates derived using the UK community land surface model (JULES, the Joint UK Land Earth Simulator) against atmospheric observations of methane, including SCIAMACHY total methane columns [5] up to 2007. We have undertaken a series of new HadGEM2 runs using new JULES emission estimates extended in time to the end of 2012, thereby allowing comparison with both SCIAMACHY and GOSAT atmospheric column methane measurements. We will describe the results of these runs and the implications for methane wetland emissions. References [1] Rigby, M., et al.: Renewed growth of atmospheric methane. Geophys. Res. Lett., 35, L22805, 2008; [2] Nisbet, E.G., et al.: Methane on the Rise-Again, Science 343, 493, 2014; [3] Kirschke, S., et al.,: Three decades of global methane sources and sinks, Nature Geosciences, 6, 813-823, 2013; [4] Melton, J. R., et al.: Present state of global wetland extent and wetland methane modelling: conclusions from a model inter-comparison project (WETCHIMP), Biogeosciences, 10, 753-788, 2013; [5] Hayman, G.D., et al.: Comparison of the HadGEM2 climate-chemistry model against in situ and SCIAMACHY atmospheric methane data, Atmos. Chem

  16. The dependence of land-atmosphere interactions on atmospheric parametrizations in the JULES/UM modelling system

    Science.gov (United States)

    Johnson, Helen; Best, Martin

    2015-04-01

    It has been understood for a while now that atmospheric behaviour is affected by land surface processes, modelling this relationship however still presents challenges. Most numerical weather prediction (NWP) models couple an atmospheric model to a land surface model in order to forecast the weather and/or climate. The Global Land-Atmosphere Coupling Experiment (GLACE) demonstrated that soil moisture variability has considerable control over atmospheric behaviour, particularly impacting on precipitation and temperature variability. The study also suggested that differences in coupling strengths between models may be due to differences in atmospheric parametrizations. There have since been other studies which support this claim but it is not yet clear which parameters control the land-atmosphere coupling strength or indeed what it should be. In this study we investigate whether certain atmospheric parameters hold more control than others over model sensitivity to land surface changes. We focus on the interaction of the JULES (Joint UK Land Environment Simulator) land surface model with the Met Office Unified Model (UM) that is used for operational NWP and climate prediction. For computational efficiency we ran the UM at a single site using a single column model (SCM) rather than running a global model simulation. A site in the Sahel region of West Africa was chosen as this is an area that was identified by GLACE as being especially responsive to changes in soil moisture. JULES was run several times with various different initial soil moisture profiles to create an ensemble of surface sensible and latent heat fluxes that could be used to force a set of different SCM runs in order to simulate a range of different atmospheric conditions. Various atmospheric parameters in the SCM were then perturbed to create additional sets of SCM runs with different sensitivities to soil moisture changes. By analysing the difference in spread between the standard configuration and the

  17. Improved representation of plant functional types and physiology in the Joint UK Land Environment Simulator (JULES v4.2) using plant trait information

    Science.gov (United States)

    Harper, Anna B.; Cox, Peter M.; Friedlingstein, Pierre; Wiltshire, Andy J.; Jones, Chris D.; Sitch, Stephen; Mercado, Lina M.; Groenendijk, Margriet; Robertson, Eddy; Kattge, Jens; Bönisch, Gerhard; Atkin, Owen K.; Bahn, Michael; Cornelissen, Johannes; Niinemets, Ülo; Onipchenko, Vladimir; Peñuelas, Josep; Poorter, Lourens; Reich, Peter B.; Soudzilovskaia, Nadjeda A.; van Bodegom, Peter

    2016-07-01

    Dynamic global vegetation models are used to predict the response of vegetation to climate change. They are essential for planning ecosystem management, understanding carbon cycle-climate feedbacks, and evaluating the potential impacts of climate change on global ecosystems. JULES (the Joint UK Land Environment Simulator) represents terrestrial processes in the UK Hadley Centre family of models and in the first generation UK Earth System Model. Previously, JULES represented five plant functional types (PFTs): broadleaf trees, needle-leaf trees, C3 and C4 grasses, and shrubs. This study addresses three developments in JULES. First, trees and shrubs were split into deciduous and evergreen PFTs to better represent the range of leaf life spans and metabolic capacities that exists in nature. Second, we distinguished between temperate and tropical broadleaf evergreen trees. These first two changes result in a new set of nine PFTs: tropical and temperate broadleaf evergreen trees, broadleaf deciduous trees, needle-leaf evergreen and deciduous trees, C3 and C4 grasses, and evergreen and deciduous shrubs. Third, using data from the TRY database, we updated the relationship between leaf nitrogen and the maximum rate of carboxylation of Rubisco (Vcmax), and updated the leaf turnover and growth rates to include a trade-off between leaf life span and leaf mass per unit area.Overall, the simulation of gross and net primary productivity (GPP and NPP, respectively) is improved with the nine PFTs when compared to FLUXNET sites, a global GPP data set based on FLUXNET, and MODIS NPP. Compared to the standard five PFTs, the new nine PFTs simulate a higher GPP and NPP, with the exception of C3 grasses in cold environments and C4 grasses that were previously over-productive. On a biome scale, GPP is improved for all eight biomes evaluated and NPP is improved for most biomes - the exceptions being the tropical forests, savannahs, and extratropical mixed forests where simulated NPP is too

  18. The Met Office Unified Model Global Atmosphere 4.0 and JULES Global Land 4.0 configurations

    Directory of Open Access Journals (Sweden)

    D. N. Walters

    2014-02-01

    Full Text Available We describe Global Atmosphere 4.0 (GA4.0 and Global Land 4.0 (GL4.0: configurations of the Met Office Unified Model and JULES (Joint UK Land Environment Simulator community land surface model developed for use in global and regional climate research and weather prediction activities. GA4.0 and GL4.0 are based on the previous GA3.0 and GL3.0 configurations, with the inclusion of developments made by the Met Office and its collaborators during its annual development cycle. This paper provides a comprehensive technical and scientific description of GA4.0 and GL4.0 as well as details of how these differ from their predecessors. We also present the results of some initial evaluations of their performance. Overall, performance is comparable with that of GA3.0/GL3.0; the updated configurations include improvements to the science of several parametrisation schemes, however, and will form a baseline for further ongoing development.

  19. The Met Office Unified Model Global Atmosphere 4.0 and JULES Global Land 4.0 configurations

    Directory of Open Access Journals (Sweden)

    D. N. Walters

    2013-05-01

    Full Text Available We describe Global Atmosphere 4.0 (GA4.0 and Global Land 4.0 (GL4.0: configurations of the Met Office Unified Model and JULES community land surface model developed for use in global and regional climate research and weather prediction activities. GA4.0 and GL4.0 are based on the previous GA3.0 and GL3.0 configurations, with the inclusion of developments made by the Met Office and its collaborators during its annual development cycle. This paper provides a comprehensive technical and scientific description of GA4.0 and GL4.0 as well as details of how these differ from their predecessors. We also present the results of some initial evaluations of their performance. These show that, overall, performance is comparable with that of GA3.0/GL3.0; the updated configurations do, however, include improvements to the science of several parametrization schemes and will form a baseline for further ongoing development.

  20. Incorporation of water vapor transfer in the JULES land surface model: Implications for key soil variables and land surface fluxes

    Science.gov (United States)

    Garcia Gonzalez, Raquel; Verhoef, Anne; Luigi Vidale, Pier; Braud, Isabelle

    2012-05-01

    This study focuses on the mechanisms underlying water and heat transfer in upper soil layers, and their effects on soil physical prognostic variables and the individual components of the energy balance. The skill of the JULES (Joint UK Environment Simulator) land surface model (LSM) to simulate key soil variables, such as soil moisture content and surface temperature, and fluxes such as evaporation, is investigated. The Richards equation for soil water transfer, as used in most LSMs, was updated by incorporating isothermal and thermal water vapor transfer. The model was tested for three sites representative of semiarid and temperate arid climates: the Jornada site (New Mexico, USA), Griffith site (Australia), and Audubon site (Arizona, USA). Water vapor flux was found to contribute significantly to the water and heat transfer in the upper soil layers. This was mainly due to isothermal vapor diffusion; thermal vapor flux also played a role at the Jornada site just after rainfall events. Inclusion of water vapor flux had an effect on the diurnal evolution of evaporation, soil moisture content, and surface temperature. The incorporation of additional processes, such as water vapor flux among others, into LSMs may improve the coupling between the upper soil layers and the atmosphere, which in turn could increase the reliability of weather and climate predictions.

  1. Scientific Satellites

    Science.gov (United States)

    1967-01-01

    followed Hale’s into orbit. In 1879, Jules Verne wrote about launching small satellites with a gun possessing a muzzle velocity of 10 000 m/sec (ref. 3...was activated in 1950.11 It was located only a few tens of miles from the spot where Jules Verne had his Baltimore Gun Club fire a manned projectile to...principle, satellites can be launched by a single impulse applied at the Earth’s surface-say, with a large cannon, & la Jules Verne (sec. 8-3). In

  2. Jules Horowitz reactor - Complementary safety assessment in the light of the Fukushima accident; Reacteur Jules Horowitz - Evaluation complementaire de la surete au regard de l'accident survenu a la centrale nucleaire de Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-09-13

    This CSA (Complementary Safety Assessment) analyses the robustness of the Jules Horowitz reactor (RJH) to extreme situations such as those that led to the Fukushima accident and proposes a series of improvements. RJH is being built on the Cadarache CEA's site. Robustness is the ability for the facility to withstand events beyond the level for which the facility was designed. Robustness is linked to safety margins but also to the situations leading to a sudden deterioration of the accident sequence (cliff edge effect). Safety is not only a matter of design or of engineered systems, it is also a matter of organization. So issues like RJH's crisis organization, the organization of radiation protection, and work organization via subcontracting are also taken into consideration. This report is divided into 9 main chapters: 1) main features of the RJH facility, 2) identification of cliff edge risks and of equipment essential for safety, 3) earthquake risk, 4) flood risk, 5) risks due to other extreme natural disasters, 6) the loss of electrical power supplies and of cooling systems, 7) management of severe accidents, 8) subcontracting policy, 9) synthesis and list of improvements. This study shows a globally good robustness of the RJH for the considered risks. Nevertheless it can considered relevant to increase the robustness of the plant on a few points: -) to increase the seismic safety margins of some pieces of equipment, -) to increase the robustness of the internal electrical power supplies, -) to increase the fuel cooling capacity, and -) to improve the management of the post-accidental period. (A.C.)

  3. The Jules Horowitz Reactor - A new High Performance European Material Testing Reactor open to International Users Present Status and Objectives

    Energy Technology Data Exchange (ETDEWEB)

    Iracane, Daniel; Bignan, Gilles [CEA Atomic Energy Commission Saclay Batiment 121- 91191 Gif Sur Yvette (France); Lindbaeck, Jan-Erik; Blomgren, Jan [VATTENFALL AB Nuclear Power Jaemtlandsgatan 99 SE-16287 Stockholm (Sweden)

    2010-07-01

    The development of sustainable nuclear energy requires R and D on fuel and material behaviour under irradiation with a high level of performance in order to meet the needs and challenges for the benefit of industry, research and public bodies. These stakes require a sustainable and secured access to an up-to-date high performance Material Testing Reactor. Following a broad survey within the European Research Area, the international community agreed that the need for Material Test Reactors in support of nuclear power plant safety and operation will continue in the context of sustainable nuclear energy. The Jules Horowitz Reactor project (JHR) copes with this context. JHR is designed as a user facility addressing the needs of the international community. This means: - flexibility with irradiation loops able to reproduce a large variation in operation conditions of different power reactor technologies, - high flux capacity to address Generations II, III, and IV needs. JHR is designed, built and operated as an international user facility because: - Given the maturity and globalization of the industry, domestic tools have no more the required level of economic and technical efficiency. Meanwhile, countries with nuclear energy need an access to high performance irradiation experimental capabilities to support technical skill and guarantee the competitiveness and safety of nuclear energy. - Many research items related to safety or public policy (waste management, etc.) require international cooperation to share costs and benefits of resulting consensus. JHR design is optimised for offering high performance material and fuel irradiation capability for the coming decades. This project is driven and funded by an international consortium gathering vendors, utilities and public stakeholders. This consortium has been set up in March 2007 when the construction began. The construction is in progress and the start of operation is scheduled for 2014. The JHR is a research

  4. Libro de las generaciones y linajes de los reyes ¿Un título vernáculo para el Liber regum?

    Directory of Open Access Journals (Sweden)

    Georges Martin

    2010-09-01

    Full Text Available El título latino Liber regum disimula el aspecto más novedoso de la obra que encabeza: el uso del romance navarro, que hace de ella la primera crónica hispana escrita en lengua vernácula y quizá el primer escrito romance de las letras hispánicas. Pero ¿sobre qué base proponer un título romance cuando las tres primeras versiones conocidas y los pocos manuscritos que las conservan ofrecen tres rotulaciones distintas?Le titre latin Liber regum cache la grande nouveauté de l’œuvre qu’il désigne : l’usage du roman navarrais, qui fait de celle-ci la première chronique hispanique écrite en langue vernaculaire, voire le premier écrit roman des lettres hispaniques. Mais, sur quelle base proposer un titre roman alors même que les trois premières versions connues et les rares manuscrits qui les conservent offrent trois intitulés distincts ?

  5. Getting the best out of long-wavelength X-rays: de novo chlorine/sulfur SAD phasing of a structural protein from ATV

    DEFF Research Database (Denmark)

    Goulet, Adeline; Vestergaard, Gisle Alberg; Felisberto-Rodrigues, Catarina

    2010-01-01

    The structure of a 14 kDa structural protein from Acidianus two-tailed virus (ATV) was solved by single-wavelength anomalous diffraction (SAD) phasing using X-ray data collected at 2.0 A wavelength. Although the anomalous signal from methionine sulfurs was expected to suffice to solve the structure......, one chloride ion turned out to be essential to achieve phasing. The minimal data requirements and the relative contributions of the Cl and S atoms to phasing are discussed. This work supports the feasibility of a systematic approach for the solution of protein crystal structures by SAD based...

  6. An observational comparison of first-line combination antiretroviral treatment (cART with 2NRTI and ATV/r or DRV/r in HIV-infected patients in Italy

    Directory of Open Access Journals (Sweden)

    Alessandro Cozzi-Lepri

    2014-11-01

    Full Text Available Introduction: In a recent clinical trial (ACTG 5257, no difference in viral failure (VF of a first-line cART containing atazanavir/r (ATV/r or darunavir/r (DRV/r was found [1]. For the endpoint of discontinuation due to intolerance, the regimen with DRV/r was superior to that of ATV/r (49% of the stops of ATV/r were attributed to jaundice or hyperbilirubinemia. These and other intolerances to ATV/r remain a concern for clinicians. Methods: Participants in the ICONA Foundation Study who started cART with 2NRTI+ ATV/r or DRV/r while ART-naïve were included. Several endpoints were evaluated: confirmed VF>200 copies/mL after six months of therapy, discontinuation of DRV/r or ATV/r for any reasons or because of intolerance/toxicity (as reported by the treating physician and the combined endpoint of VF or stop. Survival analysis with Kaplan–Meier curves and Cox regression model stratified by clinical site was used. Patients’ follow-up accrued from cART initiation to the date of the event or to the date of last available visit/viral load. Results: 894 patients starting 2NRTI+ATV/r and 686 2NRTI+DRV/r when ART-naïve on average in 2011 (IQR: 2010–2012 were studied. Most common NRTIs used were FTC/TDF (84% and ABC/3TC (12%. Median age was 40 years, 22% females, 44% heterosexuals. Patients starting ATV/r were more likely to be hepatitis B/C infected (2% and 14% vs 1% and 9%, p=0.001, they started one year earlier (2011 vs 2012, p=0.001, were more likely to be enrolled in sites located in the north of Italy (63% vs 54%, p=0.04, started cART less promptly after HIV diagnosis (5 vs 2 months, p=0.02 and less likely to have started TDF/FTC (83% vs 85%, p=0.02. By two years of cART, 9.8% (95% CI 7.6–12.0 of those starting ATV/r experienced discontinuation due to intolerance/toxicity vs 6.5% in DRV/r group (95% CI 4.2–8.8, p=0.04. After controlling for several potential confounders (age, gender, nation of birth, mode of HIV transmission, hepatitis co

  7. An observational comparison of first-line combination antiretroviral treatment (cART) with 2NRTI and ATV/r or DRV/r in HIV-infected patients in Italy.

    Science.gov (United States)

    Cozzi-Lepri, Alessandro; Antinori, Andrea; Bonora, Stefano; Cingolani, Antonella; Cassola, Giovanni; Angarano, Gioacchino; Vullo, Vincenzo; Mussini, Cristina; Gori, Andrea; Maggiolo, Franco; Castagna, Antonella

    2014-01-01

    In a recent clinical trial (ACTG 5257), no difference in viral failure (VF) of a first-line cART containing atazanavir/r (ATV/r) or darunavir/r (DRV/r) was found [1]. For the endpoint of discontinuation due to intolerance, the regimen with DRV/r was superior to that of ATV/r (49% of the stops of ATV/r were attributed to jaundice or hyperbilirubinemia). These and other intolerances to ATV/r remain a concern for clinicians. Participants in the ICONA Foundation Study who started cART with 2NRTI+ ATV/r or DRV/r while ART-naïve were included. Several endpoints were evaluated: confirmed VF>200 copies/mL after six months of therapy, discontinuation of DRV/r or ATV/r for any reasons or because of intolerance/toxicity (as reported by the treating physician) and the combined endpoint of VF or stop. Survival analysis with Kaplan-Meier curves and Cox regression model stratified by clinical site was used. Patients' follow-up accrued from cART initiation to the date of the event or to the date of last available visit/viral load. 894 patients starting 2NRTI+ATV/r and 686 2NRTI+DRV/r when ART-naïve on average in 2011 (IQR: 2010-2012) were studied. Most common NRTIs used were FTC/TDF (84%) and ABC/3TC (12%). Median age was 40 years, 22% females, 44% heterosexuals. Patients starting ATV/r were more likely to be hepatitis B/C infected (2% and 14% vs 1% and 9%, p=0.001), they started one year earlier (2011 vs 2012, p=0.001), were more likely to be enrolled in sites located in the north of Italy (63% vs 54%, p=0.04), started cART less promptly after HIV diagnosis (5 vs 2 months, p=0.02) and less likely to have started TDF/FTC (83% vs 85%, p=0.02). By two years of cART, 9.8% (95% CI 7.6-12.0) of those starting ATV/r experienced discontinuation due to intolerance/toxicity vs 6.5% in DRV/r group (95% CI 4.2-8.8, p=0.04). After controlling for several potential confounders (age, gender, nation of birth, mode of HIV transmission, hepatitis co-infection status, AIDS diagnosis, nucleoside

  8. Air Force Contract Negotiations: Importance, Roles, and Major Problems in the United States and Four NATO Countries

    Science.gov (United States)

    1982-06-01

    Aldine Publishing Co., 1964. Backman, Jules , ed. Social Responsibility and Accountability. New York: New York University Press, 1975. Bartos...Conflict. New York: Academic Press, 1970. Terpstra, Vern . International Marketing. Dryden Press, 1972. .. The Cultural Environment of International

  9. Lennujaamast ja parunist puu otsas : [lugemiselamustest] / Ülar Ploom

    Index Scriptorium Estoniae

    Ploom, Ülar

    2007-01-01

    Maailmaklassikast: Mark Twaini "Huckelberry Finni seiklused", Jules Verne'i "Saladuslik saar", Gabriel García Márquezi "Sada aastat üksildust", Aleksandr Erteli "Gardeninid", Italo Calvino "Parun puu otsas"

  10. Lennujaamast ja parunist puu otsas : [lugemiselamustest] / Ülar Ploom

    Index Scriptorium Estoniae

    Ploom, Ülar

    2007-01-01

    Maailmaklassikast: Mark Twaini "Huckelberry Finni seiklused", Jules Verne'i "Saladuslik saar", Gabriel García Márquezi "Sada aastat üksildust", Aleksandr Erteli "Gardeninid", Italo Calvino "Parun puu otsas"

  11. Participation level of water users in irrigated water management: A case study of Ban Vern Kham Pumping irrigation project, Xaithani district, Vientiane capital, Lao PDR

    Directory of Open Access Journals (Sweden)

    Phonemany Sayyasettha

    2016-10-01

    Full Text Available The objective of this research was to study the participation of water user group in irrigated water management in Ban Vern Kham Pumping Irrigation Project, Xaithani District, Vientiane Capital, Lao PDR, through the analysis of variables and the formulation of participation equation. The study included 105 households for data collection based on the developed questionnaires. The collected data were analyzed using SPSS program and expressed in the forms of frequency, percentage, mean, and standard deviation. The analysis of participation variables and stepwise multiple regression was carried out to obtain the equation used to predict the participation level in irrigated water management. Based on the main findings, the overall participation level was reported to be high, which was equal to 3.62 (the total score of 5.00 with the standard deviation of 0.149. Specifically, the participation in planning irrigation water allocation and operation and maintenance of irrigation system obtained the same highest score of 3.67, whereas the least score was the participation in allocating the benefit from irrigation water (with the score of 3.53. Additionally, the personal factors of water users were found not affecting the participation level. However, the different education level played a role in participation level in irrigation water allocation planning with the statistical significance of 0.05. The other factors such as education level, working ability, and income obtained from water user group, were found to have a moderate relationship with participation level. The analysis revealed that the water user group was relatively well established due to a strong cooperation and collaboration in working together to find equitable ways to manage irrigation water. In conclusion, the participation level in irrigated water management was a function of working ability, income obtained from water user group, and position in water user group.

  12. Arquitectura vernácula de la Sierra de Gredos y el valle del Alto Tormes (Ávila): análisis tipológico, fundamentos constructivos y funcionamiento bioclimático

    OpenAIRE

    Gil Crespo, Ignacio Javier

    2011-01-01

    El presente estudio analiza la arquitectura vernácula del valle del Alto Tormes en la Sierra de Gredos abulense en sus aspectos tipológicos —a escala territorial y a escala arquitectónica—, sus fundamentos constructivos —por los que se estudian los materiales, elementos y sistemas constructivos— y su funcionamiento bioclimático. Este último punto de vista supone una perspectiva inédita en el estudio de esta arquitectura. Se estudia mediante métodos de análisis bioclimático y se describen los ...

  13. Soluciones de diseño ambiental basadas en el análisis de la arquitectura vernácula mexicana y su prospección a futuro: el caso del envolvente

    OpenAIRE

    Aguilar Urquidez, Pavel

    2014-01-01

    Se sabe que la base para generar conocimiento científico el principio mas básico es la observación, observando aprendemos a reconocer las cosas por mas de lo que son, las sintetizamos y utilizamos a nuestra conveniencia. Esta investigación hace lo mismo, mediante la observación de la arquitectura vernácula, sintetiza los factores que utiliza como solución a las condiciones climáticas extremas del norte de México, enfoca los esfuerzos a resolver la falta de confort térmico en la vivienda de in...

  14. 2nd Charles Richet et Jules Héricourt workshop: therapeutic antibodies and anaphylaxis; May 31-June 1, 2011, Tours, France.

    Science.gov (United States)

    Daguet, Arnaud; Watier, Hervé

    2011-01-01

    The Charles Richet and Jules Héricourt workshops honor the memory of Jules Héricourt (1850-1938) and Charles Richet (1850-1935) who described the principle of serotherapy in 1888 and made the very first attempts to fight cancer with serotherapy in 1895. In 1902, Charles Richet and Paul Portier described "anaphylaxis," a discovery awarded the Nobel Prize in 1913. The first workshop, "Towards the clinical use of mAbs with higher cytolytic efficacy in cancer" was held in Tours, France on November 20-21, 2008. The second Charles Richet and Jules Héricourt workshop, held May 31-June 1, 2011 at the University of Tours, France, was also organized by the Cancéropôle Grand Ouest. The topic of the workshop was therapeutic antibodies and anaphylaxis, a subject rarely addressed in congresses focused on monoclonal antibodies. To have discussions about mAb side effects with complete objectivity, the congress was organized independently of any sponsorship from pharmaceutical companies. This academic event was motivated by the high incidence of shocks to cetuximab and the need to compile and evaluate scattered information. This growing public health concern was thus analyzed from different scientific and medical angles. The first session was devoted to acute infusion reactions, with an emphasis on deconvolution of the terms "cytokine-release syndrome," "cytokine storms," "anaphylaxis" and their epidemiology. This session concluded with the Charles Richet lecture on cetuximab anaphylaxis and anti-αGal IgE by Thomas Platts-Mills, its discoverer. In the next session, the involvement of anti-glycan antibodies in both anaphylaxis and delayed hypersensitivity reactions to therapeutic antibodies was discussed. A gala dinner was held in the gardens of the beautiful château of Villandry, which was acquired and restored by Joachim Carvalho, a pupil of Charles Richet's and great-grandfather of the present owner. The final session focused on strategies to prevent cetuximab anaphylaxis

  15. Study of the uniform corrosion of an aluminium alloy used for the fuel cladding of the Jules Horowitz experimental reactor; Etude de la corrosion uniforme d'un alliage d'aluminium utilise comme gainage du combustible nucleaire du reacteur experimental Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Wintergerst, M. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DEN/DANS/DMN/SEMI), 91 - Gif-sur-Yvette (France)

    2008-07-01

    For the Jules Horowitz new material testing reactor, an aluminium base alloy, AlFeNi, will be used for the cladding of the fuel plates. Taking into account the thermal properties of the alloy and of its oxide, the corrosion of the fuel cans presents many problems. The aim of this thesis is to provide a growing kinetic of the oxide layer at the surface of the AlFeNi fuel can in order to predict the life time of fuel element. Thus the mechanism of degradation of the cladding will be describe in order to integrate the different parameters of the operating reactor. (A.L.B.)

  16. Rapid Oceanographic Data Gathering: Some Problems in Using Remote Sensing to Determine the Horizontal and Vertical Thermal Distributions in the Northeast Pacific Ocean.

    Science.gov (United States)

    1981-09-01

    OCEANOGRAPHIC RESEARCH In 1870 and 1879 respectively, the authors Edward Everett Hale and Jules Verne wrote about placing an artificial satellite in orbit...Hale using a huge waterpowered flywheel and Verne a gun of sufficient muzzle velocity (Corliss, 1967). Hale envisioned the satellite as an aid to

  17. Insetos em presépios e as "formigas vestidas" de Jules Martin (1832-1906: uma curiosa manufatura paulistana do final do século XIX

    Directory of Open Access Journals (Sweden)

    Dante Martins Teixeira

    2008-01-01

    Full Text Available Present in Brazil since the beginning of Portuguese colonization, crèche nativity scenes were soon adapted to local reality, a propitious circumstance for the appearance of heterodox conceptions and the use of exotic elements of the fauna and flora peculiar to each region. As records about insects are very uncommon, it is noteworthy that females of leaf-cutting ants, Atta sp. (Hymenoptera, Formicidae, were used to compose crèche nativity scenes in São Paulo State. Having subsisted at least up to the decade of 1960, the "ant crèches" of cities such as Embu das Artes could be related to the then famous "dressed ants" created by Jules Martin, a curious manufacture of the city of São Paulo in the last quarter of the 19th century.

  18. Les Deux Méthodes. Conférence par Jean Jaurès et Jules Guesde à l’Hippodrome Lillois

    OpenAIRE

    2016-01-01

    Transcription à partir de l’édition : Les Deux Méthodes. Conférence par Jean Jaurès et Jules Guesde à l’Hippodrome Lillois, Lille, Imprimerie Ouvrière P. Lagrange, 1900 (sur Gallica, reproduction de l’exemplaire coté Lb57 12889). Les numéros de pages de l’édition transcrite sont renseignés entre crochets au fil du texte ; c’est à cette pagination que se réfèrent les renvois effectués dans l’analyse du document. Nous avons remplacé « Fourrier » par « Fourier » et « Carrette » par « Carette » ;...

  19. Networking the Global Maritime Partnership

    Science.gov (United States)

    2008-06-01

    OEF TASKING FS AIGLE (MHC) FS DAGUE (LCT) FS D’ENTRECASTEAUX (AGS) FS FLOREAL (FFG) FS ISARD (AG) FS JULES VERNE (AD) FS LA LAVALLEE (FFG) FS LOIRE...from Galdorisi notes transcription). 25 Rodger, presentation to King-Hall. 26 Former CNO, Admiral Vern Clark described FORCEnet as an...weapons into a networked, distributed combat force.” Admiral Vern Clark, “Sea Power 21: Projecting Decisive Joint Capabilities,” United States

  20. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor; Contribution a l'etude des incertitudes des parametres neutroniques d'un coeur compact et heterogene: le reacteur d'irradiation Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Di Salvo, J

    2002-07-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  1. The Role of History in Teaching Science--A Case Study: The Popularization of Science in Nineteenth-Century France.

    Science.gov (United States)

    Hendrick, Robert M.

    1992-01-01

    Examines one of the key methods used to stimulate bourgeois interest in science in France during the Second Empire and early Third Republic; the campaign to create a popularized science. Concentrates on the "science writings" of Jules Michelet and Jules Verne, both of whom were immensely successful in creating a favorable climate of…

  2. Military Use of the International Space Station

    Science.gov (United States)

    1988-11-01

    projectile ( Jules Verne , 1865, and others); or, when all else failed, anti-gravity machines, paint, or water. W. von Braun and F. Ordway, History of Rocketry...centuries. From Lucian’s second century account of a sailing ship being swept by winds to the moon I to Jules Verne’s De la Terre a La Lune (From the Earth...Travel, at 9 (rev. ed. 1969). 2J. Verne , From the Earth to the Moon (1970 ed.). 3Hall, The Brick Moon, Atl. Monthly, Oct. 1869, at 451; Nov. 1869, at

  3. Methodology for Developing a Probabilistic Risk Assessment Model of Spacecraft Rendezvous and Dockings

    Science.gov (United States)

    Farnham, Steven J., II; Garza, Joel, Jr.; Castillo, Theresa M.; Lutomski, Michael

    2011-01-01

    In 2007 NASA was preparing to send two new visiting vehicles carrying logistics and propellant to the International Space Station (ISS). These new vehicles were the European Space Agency s (ESA) Automated Transfer Vehicle (ATV), the Jules Verne, and the Japanese Aerospace and Explorations Agency s (JAXA) H-II Transfer Vehicle (HTV). The ISS Program wanted to quantify the increased risk to the ISS from these visiting vehicles. At the time, only the Shuttle, the Soyuz, and the Progress vehicles rendezvoused and docked to the ISS. The increased risk to the ISS was from an increase in vehicle traffic, thereby, increasing the potential catastrophic collision during the rendezvous and the docking or berthing of the spacecraft to the ISS. A universal method of evaluating the risk of rendezvous and docking or berthing was created by the ISS s Risk Team to accommodate the increasing number of rendezvous and docking or berthing operations due to the increasing number of different spacecraft, as well as the future arrival of commercial spacecraft. Before the first docking attempt of ESA's ATV and JAXA's HTV to the ISS, a probabilistic risk model was developed to quantitatively calculate the risk of collision of each spacecraft with the ISS. The 5 rendezvous and docking risk models (Soyuz, Progress, Shuttle, ATV, and HTV) have been used to build and refine the modeling methodology for rendezvous and docking of spacecrafts. This risk modeling methodology will be NASA s basis for evaluating the addition of future ISS visiting spacecrafts hazards, including SpaceX s Dragon, Orbital Science s Cygnus, and NASA s own Orion spacecraft. This paper will describe the methodology used for developing a visiting vehicle risk model.

  4. Les stratégies d’insertion de l’éthique dans Le Cachet d’Onyx de Jules Barbey d’Aurevilly

    Directory of Open Access Journals (Sweden)

    Alice De Georges-Métral

    2011-01-01

    Full Text Available Barbey d’Aurevilly, qui se place sous la tutelle de Joseph de Maistre, déploie paradoxalement dans sa production romanesque toutes les nuances du thème sulfureux du plaisir de la transgression. Pontmartin stigmatise ce décalage entre la morale et le récit en reprochant à Jules Barbey d’Aurevilly de penser comme Joseph de Maistre et d’écrire comme le Marquis de Sade. Le Cachet d’Onyx, première nouvelle de Jules Barbey d’Aurevilly, écrite en 1831, est effectivement représentative de l’inscription ambivalente de la morale dans la fiction. Cette nouvelle établit des stratégies d’écriture retorses par le truchement de l’emboîtement des récits. Elle définit tout d’abord, dans le récit-cadre, une axiologie proche de ce que son auteur identifie comme une doxa, pour en révéler l’absence de fondement. La métadiégèse présente un système de valeurs inverse. Cette dissonance semble avoir pour fonction de remplacer un système évaluatif par un autre qui lui est concurrent. Or, la polyphonie des indications de lecture fournies par le narrateur, l’intertexte et le texte s’entrechoquent sans livrer de solution satisfaisante. Implicitement, c’est l’éviction de toute axiologie stable que vise la stratégie narrative du Cachet d’onyx. In his novelistic writings, Barbey d'Aurevilly, who sets himself in Joseph de Maistre's ideology, paradoxically spreads out all the nuances of the sulphurous topic of the pleasure of transgression. Pontmartin denounces this discrepancy between morality and the narrative while reproaching Jules Barbey d'Aurevilly for thinking like Joseph de Maistre and writing like the Marquis de Sade. Le cachet d'Onyx, Barbey d'Aurevilly's first short story, written in 1831, is indeed representative of the ambivalent writing of morality in fiction. This short story establishes strategies of sly style by the means of interlocking narratives. First of all, in the framework story, it defines an

  5. Inquiry in the public interest, held at Cadarache into the construction of the reactor 'Jules Horowitz' and the problems related to the public dialogue; L'enquete d'utilite publique sur la creation du 'reacteur Jules Horowitz' a Cadarache et la participation locale

    Energy Technology Data Exchange (ETDEWEB)

    Bottiglioni, F

    2007-07-15

    In this paper are presented the main points of the inquiry taken by an official board into the demand of the Cea to create a new research tool, the 'Jules Horowitz Reactor', in its research center of Cadarache. The increasing involvement of the people in the decision-making procedures dealing with important projects is summed up, so as the distinctive features of the different regulations that frame the public participation are stressed. Some improvements are suggested to carry through next inquiries faster and more easily. The participation of the public has been low: only 11 people or associations have left their remarks to the inquiry members despite the large audience that attended the different meetings and debates organized on the issue by the CNDP (national board for public debate)

  6. Burtnieku novada nekroģeogrāfija. Atvērto kapsētu veidošanas prakse

    OpenAIRE

    Seļicka, Anita

    2012-01-01

    Maģistra darba „Burtnieku novada nekroģeogrāfija. Atvērto kapsētu veidošanas prakse” mērķis ir izvērtēt Burtnieku novada aktīvo kapsētu veidošanas praksi nekroģeogrāfijas koncepciju un pieeju kontekstā. Pētījuma teorētiskajā daļā tiek apskatīts nekroģeogrāfijas koncepts, dažādās kapsētas jēdziena uztveres un duālismi tajā. Darbā analizēti piecu Burtnieku novada kapsētu telpiskie elementi, to struktūras veidošanās, tiesiskais regulējums, iesaistīto personu un apkārtējās teritorijas konteksts k...

  7. Evaluation of a photosynthesis-based biogenic isoprene emission scheme in JULES and simulation of isoprene emissions under present-day climate conditions

    Directory of Open Access Journals (Sweden)

    F. Pacifico

    2011-05-01

    Full Text Available We have incorporated a semi-mechanistic isoprene emission module into the JULES land-surface scheme, as a first step towards a modelling tool that can be applied for studies of vegetation – atmospheric chemistry interactions, including chemistry-climate feedbacks. Here, we evaluate the coupled model against local above-canopy isoprene emission flux measurements from six flux tower sites as well as satellite-derived estimates of isoprene emission over tropical South America and east and south Asia. The model simulates diurnal variability well: correlation coefficients are significant (at the 95 % level for all flux tower sites. The model reproduces day-to-day variability with significant correlations (at the 95 % confidence level at four of the six flux tower sites. At the UMBS site, a complete set of seasonal observations is available for two years (2000 and 2002. The model reproduces the seasonal pattern of emission during 2002, but does less well in the year 2000. The model overestimates observed emissions at all sites, which is partially because it does not include isoprene loss through the canopy. Comparison with the satellite-derived isoprene-emission estimates suggests that the model simulates the main spatial patterns, seasonal and inter-annual variability over tropical regions. The model yields a global annual isoprene emission of 535 ± 9 TgC yr−1 during the 1990s, 78 % of which from forested areas.

  8. Evaluation of a photosynthesis-based biogenic isoprene emission scheme in JULES and simulation of isoprene emissions under modern climate conditions

    Directory of Open Access Journals (Sweden)

    F. Pacifico

    2010-11-01

    Full Text Available We have incorporated a semi-mechanistic isoprene emission module into the JULES land-surface scheme. We evaluate the coupled model against local above-canopy isoprene emission flux measurements from six flux tower sites as well as satellite-derived estimates of isoprene emission over tropical South America and east and south Asia. The model simulates diurnal variability well: correlation coefficients are significant (at the 95% level for all flux tower sites. The model reproduces day-to-day variability with significant correlations (at the 95% confidence level at four of the six flux tower sites. At the UMBS site, a complete set of seasonal observations is available for two years (2000 and 2002. The model reproduces the seasonal pattern of emission during 2002, but does less well in the year 2000. Comparison with the satellite-derived isoprene-emission estimates suggests that the model simulates the main spatial patterns, seasonal and inter-annual variability over tropical regions. The model yields a global annual isoprene emission during the 1990s of 380 ± 7 TgC yr−1.

  9. Conversations avec Jules Hoüel regards sur la géométrie non euclidienne et l’analyse infinitésimale vers 1875

    CERN Document Server

    Nabonnand, Philippe

    2017-01-01

    Jules Hoüel (1823-1886) a occupé une place particulière dans les mathématiques en France durant la seconde partie du 19ème siècle. Par ses travaux de traduction et ses recensions, il a vivement contribué à la réception de la géométrie non euclidienne de Bolyai et Lobatchevski ainsi qu’aux débats sur les fondements de l’analyse. Il se situe au centre d’un vaste réseau international de correspondances en lien avec son rôle de rédacteur pour le Bulletin des sciences mathématiques et astronomiques. Cet ouvrage contient les correspondances actives et passives de Hoüel avec Joseph-Marie De Tilly, Gaston Darboux et Victor-Amédée Le Besgue ainsi qu’une introduction qui se focalise sur la découverte de l’impossibilité de démontrer le postulat des parallèles d’Euclide et l’apparition des premiers exemples de fonctions continues non dérivables.

  10. Aproximación a la descripción de las prácticas de escritura vernácula en Internet de estudiantes chilenos de enseñanza superior

    Directory of Open Access Journals (Sweden)

    María Inés Pérez Aguilar

    2017-01-01

    Full Text Available El presente artículo es un compendio del estudio interpretativo de naturaleza cualitativa –denominado “Prácticas de escritura vernácula en Internet: Estudio cualitativo de las competencias comunicativas en estudiantes de enseñanza superior”–, que tuvo como objetivos describir las prácticas letradas vernáculas en el ámbito de las comunicaciones digitales escritas, de un grupo de estudiantes de la educación superior chilena, y caracterizar las competencias comunicativas implicadas en estas prácticas. Mediante un diseño de investigación narrativa, el estudio se basó en entrevistas y el acceso a espacios personales en Internet de cuatro jóvenes, entre 18 y 22 años, quienes, dentro de un grupo de 124 estudiantes, presentaron el peril de producto res de contenidos en Internet y manifestaron su voluntad de participar. Los resultados permitieron identiicar dos grandes divisiones en la categorización de los datos obtenidos: los signiicados y las formas. La primera correspondiente a los contextos, contenidos y inalidades que motivan estos escritos. La segunda, que alude a las formas de estos mensajes y que conluyen con las funciones del lenguaje. De la interpretación y análisis de lo anterior, se identiicaron las prácticas letradas en estudio, como un espacio de manifestación de los procesos de subjetivación de los sujetos de estudio, instaladas en el marco de lo denominado ciberculturas juveniles, advirtiéndose la inminente diversiicación del concepto de competencia comunicativa. A modo conclusivo se describió el estado de estas prácticas y se caracterizaron las competencias comunicativas en el marco de un conjunto de conocimientos, habilidades y actitudes en el uso de la lengua, requerido para consumir, producir, compartir y difundir contenidos en los escenarios virtuales.

  11. On stage at the Globe

    CERN Document Server

    2005-01-01

    The Globe's first season this year is to be rounded off with two shows that are in perfect keeping with the centenary of the death of Jules Verne and Albert Einstein's theory of relativity. 'Signé Jules Verne' (Signed Jules Verne) The Miméscope company, which has already thrilled audiences at CERN with shows such as the 'Oracle of Delphi' and, more recently, 'Point de Suspension', returns with an interactive show entitled 'Signé Jules Verne'. Imagine a slightly crazy machine, which rolls along on wheels, floats, flies or moves in any other way you like, as long as it works on scientific principles. This is the task that Jules Verne sets his audience. Experiments, models, drawings, blueprints, he's interested in them all. In its typical style, Miméscope has created a world of enchantment that combines theatre, choreography, music and lighting effects in a show that evolves as a function of its audience. Performances at 3.00 p.m. on 4, 7, 10 and 11 December An interactive show for the general public...

  12. Speech by Prime Minister Francois Fillon. Visit of the Jules Horowitz experimental reactor works on the Commissariat a l'Energie et aux Energies Alternatives site. Cadarache, May 3, 2010; Discours du Premier ministre Francois FILLON Cadarache, lundi 3 mai 2010. Visite du chantier du Reacteur experimental Jules Horowitz sur le site du Commissariat a l'Energie Atomique et aux Energies Alternatives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    In this speech, the French Prime Minister evokes the present context, the importance of strategic technologies, and the challenge of investing in these technologies within a context of reduction of public expenses. He comments the decision of his government to finance research and education activities in different domains, and more specifically in the energy sector with this fourth generation Jules Horowitz experimental reactor. He recalls that the nuclear sector has always been very important to the eyes of the successive French governments, and outlines how this reactor will contribute to reactor operational optimization, lifetime extension and safety, nuclear fuel development, etc.

  13. The Jules Horowitz reactor: complementary safety evaluation in the light of the Fukushima 1 nuclear power station accident; Reacteur Jules Horowitz evaluation complementaire de la surete au regard de l'accident servenu a la centrale nucleaire de Fukushima 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This report proposes a complementary safety evaluation of the Jules Horowitz reactor in Cadarache (INB 172), one of the French basic nuclear installations (BNI, in French INB) in the light of the Fukushima accident. This evaluation takes the following risks into account: risks of flooding, earthquake, loss of power supply and loss of cooling, in addition to operational management of accident situations. It presents the main characteristics of the installation, identifies the risks of a cliff effect and the main structures and equipment, evaluates the seismic risk (installation sizing, installation conformity, margin evaluation), evaluates the flooding risk (installation sizing, installation conformity, margin evaluation), briefly examines other extreme natural phenomena (extreme meteorological conditions related to flooding, earthquake or flooding with a higher level than that for which the installation is designed). It analyzes the risk of a loss of power supply and of cooling (loss of external and internal electric sources, loss of the ultimate cooling system). It analyzes the management of severe accidents: crisis management organization, available intervention means, robustness of available means. It discusses the conditions of the use of subcontractors

  14. International Systems Integration on the International Space Station

    Science.gov (United States)

    Gerstenmaier, William H.; Ticker, Ronald L.

    2007-01-01

    Over the next few months, the International Space Station (ISS), and human spaceflight in general, will undergo momentous change. The European Columbus and Japanese Kibo Laboratories will be added to the station joining U.S. and Russian elements already on orbit. Columbus, Jules Vernes Automated Transfer Vehicle (ATV) and Kibo Control Centers will soon be joining control centers in the US and Russia in coordinating ISS operations and research. The Canadian Special Purpose Dexterous Manipulator (SPDM) will be performing extra vehicular activities that previously only astronauts on EVA could do, but remotely and with increased safety. This paper will address the integration of these international elements and operations into the ISS, both from hardware and human perspectives. Interoperability of on-orbit systems and ground control centers and their human operators from Europe, Japan, Canada, Russia and the U.S. pose significant and unique challenges. Coordination of logistical support and transportation of crews and cargo is also a major challenge. As we venture out into the cosmos and inhabit the Moon and other planets, it's the systems and operational experience and partnership development on ISS, humanity's orbiting outpost that is making these journeys possible.

  15. 享乐ATV--2011 Yamaha Raptor 120ATV

    Institute of Scientific and Technical Information of China (English)

    刘宇飞

    2011-01-01

    雅马哈Raptor系列ATV一直是竞技场上的优秀选手,2011年雅马哈推出全新Raptor125以填补125ml级别在ATV市场的空缺。它的设计初衷就是给没有ATV运动经验的骑手提供一款高质量、容易驾驭的ATV。合适的动力,极佳的悬挂和操控,在Raptor125身上得以体现。

  16. Methodological developments and qualification of calculation schemes for the modelling of photonic heating in the experimental devices of the future Jules Horowitz material testing reactor (RJH); Developpements methodologiques et qualification de schemas de calcul pour la modelisation des echauffements photoniques dans les dispositifs experimentaux du futur reacteur d'irradiation technologiques Jules Horowitz (RJH)

    Energy Technology Data Exchange (ETDEWEB)

    Blanchet, D

    2006-07-01

    The objective of this work is to develop the modelling of the nuclear heating of the experimental devices of the future Jules Horowitz material testing reactor (RJH). The strong specific nuclear power produced (460 kW/l), induces so intense photonic fluxes which cause heating and large temperature gradients that it is necessary to control it by an adequate design. However, calculations of heating are penalized by the very large uncertainties estimated at a value of about 30% (2*{sigma}) coming from the gaps and uncertainties of the data of gamma emission present in the libraries of basic nuclear data. The experimental program ADAPh aims at reducing these uncertainties. Measurements by thermoluminescent detectors (TLD) and ionisation chambers are carried out in the critical assemblies EOLE (Mox) and Minerve (UO{sub 2}). The rigorous interpretation of these measurements requires specific developments based on Monte-Carlo simulations of coupled neutron-gamma and gamma-electron transport. The developments carried out are made different in particular by the modelling of cavities phenomena and delayed gamma emissions by the decay of fission products. The comparisons calculation-measurement made it possible to identify a systematic bias confirming a tendency of calculations to underestimate measurements. A Bayesian method of adjustment was developed in order to re-estimate the principal components of the gamma heating and to transpose the results obtained to the devices of the RJH, under conditions clearly and definitely representative. This work made possible to reduce significantly the uncertainties on the determination of the gamma heating from 30 to 15 per cent. (author)

  17. Optimización de una metodología de análisis para la rehabilitación y protección sostenible de la arquitectura vernácula. Una Metodología de investigación aplicada a zonas de valor constructivo, ecológico y cultural

    OpenAIRE

    Vásquez Fierro, Virginia Verónica

    2009-01-01

    Se ha definido la Arquitectura Vernácula como el universo auto construido de distintos pueblos que legan su testimonio constructivo y que sintetizan los valores arquitectónicos, sociales y culturales, aún vigentes en algunos casos hasta los días de hoy; sin embargo, a menos que sean de grandes civilizaciones y reconocido status monumental, se desperfilan como arquitecturas precarias y no como la respuesta clave que tiene y ha tenido el ser humano para convivir sosteniblemente con el medio nat...

  18. A Glimpse of the Future: The 62nd PTTI Systems & Applications Meeting November 2030

    Science.gov (United States)

    2009-11-01

    FORECASTING Though seeing into the future is difficult, some people have been able to forecast tomorrow’s technology with amazing accuracy. Jules ... Verne wrote about manned flight to the moon from a launch base in Florida in 1865 [1], and Arthur C. Clarke described the use of communications...Precise Time – William Cashin and Qinghua Wang Relativity in Everyday Systems – Aaron Dahlen. REFERENCES [1] J. Verne , 1865, From the Earth

  19. Perchlorate Destruction and Potable Water Production Using Membrane Biofilm Reduction and Membrane Filtration

    Science.gov (United States)

    2013-11-18

    Owner David Friese APTwater APTwater 2516 Verne Roberts Circle, Suite H-102 Antioch, CA 94509 Phone 562-661-4999 X612 Cell 925-708-0480...Email dfriese@aptwater.com Project Manager Ryan Overstreet APTwater 2516 Verne Roberts Circle, Suite H-102 Antioch, CA 94509 Phone 562-661... Julee M. From: Arucan, Clyde Sent: Monday, August 22, 2011 1:20 PM To: Evans, Patrick; Berokoff, Daniel; Smith, Jennifer L. Cc: David Friese; Ryan

  20. Modern Technology Transforming Virtuosos Into Conductors

    Science.gov (United States)

    2010-04-01

    is a killer in the battlespace Inhibits decisiveness Overwhelms the receiver Jeopardizes the mission Don’t discount fantasy/Science Fiction Jules   Vern ...Inhibits decisiveness Overwhelms the receiver Jeopardizes the mission Don’t discount fantasy/Science Fiction Jules   Vern   ‐ Nuke Subs Robert Heinlein – Starship Troopers      George Lucas ‐ Starwars 5/4/2010 15SSTC 2010

  1. CNS safety at 48-week of switching to ATV/r plus 3TC or two nucleos(tides in HIV-suppressed patients on stable ART: the SALT neurocognitive sub-study

    Directory of Open Access Journals (Sweden)

    Ignacio Pérez Valero

    2014-11-01

    Full Text Available Introduction: Due to their low CNS penetrance, there are concerns about the capacity of non-conventional PI-based ART (monotherapy and dual therapies to preserve neurocognitive performance (NP. Methods: We evaluated the NP change of aviremic participants of the SALT clinical trial (1 switching therapy to dual therapy (DT: ATV/r+3TC or triple therapy (TT: ATV/r+2NRTI who agreed to perform an NP assessment (NPZ-5 at baseline and W48. Neurocognitive impairment and NP were assessed using AAN-2007 criteria (2 and global deficit scores (GDS (3. Neurocognitive change (GDS change: W48 – baseline and the effect of DT on NP evolution crude and adjusted by significant confounders were determined using ANCOVA. Results: A total of 158 patients were included (Table 1. They had shorter times because HIV diagnosis, ART initiation and HIV-suppression and their virologic outcome at W48 by snapshot was higher (79.1% vs 72.7%; p=0.04 compared to the 128 patients not included in the sub-study. By AAN-2007 criteria, 51 patients in each ART group (68% vs 63% were neurocognitively impaired at baseline (p=0.61. Forty-seven patients were not reassessed at W48: 30 lost of follow-up (16 DT-14 TT and 17 had non-evaluable data (6 DT-11 TT. Patients retested were more likely to be men (78.9% vs 61.4% and had neurological cofounders (9.6% vs 0% than patients non-retested. At W48, 3 out of 16 (5.7% patients on DT and 6 out of 21 (10.5% on TT who were non-impaired at baseline became impaired (p=0.49 while 10 out of 37 (18.9% on DT and 7 out of 36 (12.3% on TT who were neurocognitively impaired at baseline became non-impaired (p=0.44. Mean GDS changes (95% CI were: Overall −0.2 (−0.3 to −0.04: DT −0.26 (−0.4 to −0.07 and TT −0.08 (−0.2 to 0.07. NP was similar between DT and TT (0.15. This absence of differences was also observed in all cognitive tests. Effect of DT: −0.16 [−0.38 to 0.06] (r2=0.16 on NP evolution was similar to TT (reference, even after

  2. Modeling on dynamic characteristics of ATV frame with elastically mounted engine%全地形车车架挂发动机结构动态特性建模方法

    Institute of Scientific and Technical Information of China (English)

    徐中明; 余烽; 汪先国; 邱兆强; 史方圆

    2011-01-01

    Based on simulations and tests on all-terrain vehicle (ATV) body, a simple and common finite-element modeling method was proposed, in which the engine was simplified as a meshed cuboid structure with the same centroid,weight and rotary inertia and the engine was linked to MPCs fixed on the frame through SPRING elements. Considering nonlinear changes of elastic engine suspension stiffness in different operating conditions, the influences of the proposed modeling method on structural dynamic characteristic of ATV body under different suspension stiffness were studied. The results show that the modeling method can meet engineering requirements. This simple and common modeling method is useful to know the structural dynamic characteristics of ATV frame elastically connected with engine in the phases of product design and retrofit.%全地形车车架挂发动机的结构动态特性好坏很大程度上决定其整车振动舒适性及可靠性,但目前针对车架弹性挂发动机的有限元建模没有一种简单、有效且通用的方法.通过对多款车架弹性挂发动机结构动态特性的计算和实验分析,提出了全地形车车架弹性挂发动机结构的一种简单且具有通用性的有限元建模方法--把发动机简化为质心、质量、转动惯量与发动机均相同的长方体,并网格化,通过SPRING单元将发动机与建立在车架上的MPC单元连接来模拟车架弹性挂发动机的状态.考虑到全地形车行驶中,发动机弹性悬置件刚度在各种工况下会发生非线性变化,分析了所提建模方法在悬置件刚度变化情况下对车架弹性挂发动机结构动态特性分析结果的影响.结果表明所提出的车架弹性挂发动机有限元建模方法仍然可以保证对其结构动态特性的分析在工程参考要求范围内.该建模方法对于弹性挂发动机全地形车的设计和开发具有简易性和通用性,可在产品设计和改型阶段就能了解车架弹性挂发动机结构的动态特性.

  3. Kirjandus ja vabamüürlus / Paavo Matsin

    Index Scriptorium Estoniae

    Matsin, Paavo, 1970-

    2009-01-01

    Loetletakse vabamüürlastest kirjanikke (pikemalt Jules Verne'ist, Gustav Meyrinkist, Rudyard Kiplingist ja Mait Metsanurgast) ning vabamüürlikke tegelasi või motiive kasutanud kirjanikke (Lev Tolstoi, Fjodor Dostojevski, Mihhail Bulgakov, Edgar Allan Poe)

  4. Computer-Assisted Eye Examination: Background and Prospects.

    Science.gov (United States)

    1982-05-01

    bookkeeping work. The most successful prophet of lcchnology, Jules Verne , predicted much of 20th century technical progress. Few scientists took him...de los antojos Seville: Diego Perez, De Valdds. B. D. (1623b) Usit de los antajos. Ed M Mhrque. Madrid: Julio Casano. Westheimer, G. (19571

  5. An Analysis of Tactical Military Airlift

    Science.gov (United States)

    1997-09-01

    Major William Scott of AFIT; MSGT (Ret.) Gaye Summitt and MSGT (Ret.) Vern Moore, who took a fledgling Lieutenant under their wings and molded him into...Decision: The Siege of Khe Sanh. New York: Houghton Mifflin Company. Roy, Jules . 1965. The Battle of Dienbienphu. New York: Harper & Row. Shore, Moyers

  6. What Is Steampunk, and Do I Want It in My Library?

    Science.gov (United States)

    Rozmus, Emily

    2011-01-01

    What is steampunk? Most call it Victorian science fiction. Steampunk can claim such authors as H.G. Wells and Jules Verne as its earliest writers. These two Victorian/Edwardian era writers created steampunk settings in books such as "The Time Machine" and "Journey to the Center of the Earth". In the 1990s, writers such as William Gibson, Bruce…

  7. Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. First Followup Examination Results. Volume 1

    Science.gov (United States)

    1987-10-01

    follovup examination, 4 vere Ranch Hands and 6 vere Comparisons. This difference vas not statistically s$gnific nt and the data vern insufficlant for...higher proportion of individuals with white blood cell eounts exceeding 10,000/mm was in the exposed group. hase~ jule Sume.ary Lesults A nunber of

  8. Leadership in the Era of the Human Singularity: New Demands, New Skills, New Response

    Science.gov (United States)

    2008-10-01

    Leadership in the era of the human singuLarity84 Such claims are not based on the Late Victorian and Edwardian futurism of H.G. Welles, Edward Bellamy, Jules ... Verne , and the great expositions of the 1890s and early 1900s. In the first place, we have today many, many times more experience observing the

  9. Reach for the Stars: Visions for Literacy Coaching Programs

    Science.gov (United States)

    DeFord, Diane

    2012-01-01

    This brief by the Literacy Coaching Clearinghouse is about reaching for the stars--stories of vision and commitment from educators in small and large schools. Everyone knows of people who are held up as "visionaries" throughout history: Leonardo Da Vinci, Mahatma Gandhi, Jules Verne, Thomas Edison, Susan Anthony, or John Dewey, to name a few. The…

  10. Chemistry and Defects in Semiconductor Heterostructures. Materials Research Society Symposium Proceedings. Volume 148

    Science.gov (United States)

    1990-05-01

    energ7y for an overomowtbh (141. This work was sapported by’he𔃿.lpartmest ofPCro-t-CC-’F D53) r. Jules Soatbort, contract monitor, for which muon...found, indicating a single crystalline material. The patterns, however, are verN sensitive to small non-uniform lattice strains which can be detected to

  11. Detjam kapitana Granta privezli iz Ameriki bizonov i straussov / Margarita Golovanova

    Index Scriptorium Estoniae

    Golovanova, Margarita

    2006-01-01

    Kuidas "Mosfilmis" filmiti Jules Verne'i järgi mängufilmi "Kapten Granti lapsed" : režissöör Vladimir Vainshtok : helilooja Isaak Dunajevski : näitlejad Nikolai Tsherkassov, Jakov Segel : NSV Liit 1936

  12. What Is Steampunk, and Do I Want It in My Library?

    Science.gov (United States)

    Rozmus, Emily

    2011-01-01

    What is steampunk? Most call it Victorian science fiction. Steampunk can claim such authors as H.G. Wells and Jules Verne as its earliest writers. These two Victorian/Edwardian era writers created steampunk settings in books such as "The Time Machine" and "Journey to the Center of the Earth". In the 1990s, writers such as William Gibson, Bruce…

  13. Kirjandus ja vabamüürlus / Paavo Matsin

    Index Scriptorium Estoniae

    Matsin, Paavo, 1970-

    2009-01-01

    Loetletakse vabamüürlastest kirjanikke (pikemalt Jules Verne'ist, Gustav Meyrinkist, Rudyard Kiplingist ja Mait Metsanurgast) ning vabamüürlikke tegelasi või motiive kasutanud kirjanikke (Lev Tolstoi, Fjodor Dostojevski, Mihhail Bulgakov, Edgar Allan Poe)

  14. Detjam kapitana Granta privezli iz Ameriki bizonov i straussov / Margarita Golovanova

    Index Scriptorium Estoniae

    Golovanova, Margarita

    2006-01-01

    Kuidas "Mosfilmis" filmiti Jules Verne'i järgi mängufilmi "Kapten Granti lapsed" : režissöör Vladimir Vainshtok : helilooja Isaak Dunajevski : näitlejad Nikolai Tsherkassov, Jakov Segel : NSV Liit 1936

  15. 2343-IJBCS-Article-Ngueguim Jules Roger

    African Journals Online (AJOL)

    hp

    affinity with forest undergrowth such as: Tabernaemontana pachysiphon, T. crassa, Mallotus oppositifolius ..... in the under storey of pine plots is poor, this may result ... considerably limits the light that reaches the .... O'Hara K, Walters B 2006.

  16. World Tour

    CERN Multimedia

    Tauxe,H

    H.C.Tauxe est Dr.ès lettres de l'Université de Lausanne et a enseigné la philosophie jusqu'en 1962. Ensuite il s'est tourné vers le journalisme, et dans ce cadre il a fait le voyage, qui sera le thème de sa conférence, en suivant ce qui a écrit Jules Verne.

  17. Presentation of the Jules Horowitz reactor; Presentation du reacteur Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Dupuy, J.P. [AREVA-Technicatome, 13 - Aix en Provence (France); Perotto, G. [AREVA Framatome ANP, 92 - Paris La Defense (France); Ithurrald, G. [Electricite de France (EDF), 13 - Aix en Provence (France)

    2005-07-01

    The concepts on which the RJH reactor has been designed are: -) flexibility: the reactor must be able to give experimental support to any type of reactor (light water- heavy water- gas- or molten metal-cooled power reactor); -) adaptability: RJH's operating life will be over 50 years so the reactor will have to adjust to the experimental needs that may change a lot over a so long period; -) reactor operation: RJH is optimized to produce an availability time of 275 full charge equivalent days a year; and -) costs: the minimization of experiment costs is obtained through the integration in the same facility (or located nearby on the site) of the technical means required to perform a complete experimental program from the design of the irradiation device to its recovery after irradiation and to the examination or the possible testing of the samples. Transport costs and time delays are spared. This article gives the main features of the RJH facility from the description of the building to the specificities of the reactor core. (A.C.)

  18. Teatr im. Mossoveta - vernõi drug Tallintsev / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2006-01-01

    5.-7. juulini toimuvad Estonia teatris Moskva Mossoveti-nim. Teatri külalisetendused. Mängitakse Juri Jerjomini lavastusi "Mees, naine ja armuke" (F. Dostojevski ja I. Turgenevi teoste põhjal) ja Tennessee Williamsi "Tramm nimega Iha". Tutvustavalt teatrist ja teatri varasematest külalisetendustest Tallinnas 1996, 1998 ja 2004

  19. Evaluation of ATV Track Systems for Winter Mountain Operations

    Science.gov (United States)

    2011-06-01

    range on-trail operations. Résumé …..... Le présent document traite de l’évaluation de véhicules tout terrain ( VTT ) munis de systèmes de chenilles...les petits VTT à chenilles seront utiles dans les situations nécessitant une bonne maniabilité et une grande mobilité sur des pentes abruptes et...better choice. iv DRDC Suffield TM 2011-073 Sommaire ..... Évaluation de systèmes de chenilles de VTT pour des opérations hivernales en

  20. The astronomer Jules Janssen a globetrotter of celestial physics

    CERN Document Server

    Launay, Françoise

    2012-01-01

    Every aspect of the personality of Janssen (1824—1907) – that D’Artagnan of science, this bard of the Sun, and this audacious master builder – is covered here by Françoise Launay, his attentive and equally erudite biographer. A physicist, inventor and builder, Janssen was guided by his energy and curiosity. His research followed two directions: on the one hand the atmospheres of the Earth and the Sun, and on the other, two techniques: spectroscopy and photography. Among his numerous voyages across the globe, he went to Japan in 1874 to follow the transit of Venus in front of the Sun, the same year in which he invented his famous photographic revolver, which was, in truth, a great technical success. To observe the Sun during total eclipses he traveled to the Indies in 1868, to Oran in 1870 (escaping from besieged Paris by balloon!), returned to India in 1871, left for Siam in 1875 and, in 1883, for an island in the Pacific. One can thus understand why Henriette often complained of the solitude in whic...

  1. 1286-IJBCS-Article-André Jules Ibouda

    African Journals Online (AJOL)

    hp

    1 Université de Ouagadougou, Centre de Recherche en Sciences Biologiques Alimentaires et Nutritionnelles ... des substituts d'autres protéines (œuf par ... grand nombre de structures différentes. ... Structure et organisation de la micelle de.

  2. Historical note: Jules Séglas on language in dementia.

    Science.gov (United States)

    Obler, L K; Albert, M L

    1985-03-01

    In his book Des troubles du language chez les aliénés (1892) Séglas applied the model of language processing of his teacher, Charcot, to analyze the language disorders of various groups of mentally ill, including patients considered to suffer from dementia. Among the language phenomena he described from dementia are logorrhea, neologisms, embolalia, near-mutism, angophrasia, automatic speech, alexia, and agraphia. Séglas must be credited for his early descriptions of how language behaviors cluster in various psychiatric and dementing diseases.

  3. Chronophotography: engineer of life: Etienne-Jules Marey

    Directory of Open Access Journals (Sweden)

    Stojmenović Dragan

    2016-01-01

    Full Text Available The centre of the problem of understanding the process of movement control, incorporated in cognitive biomechanics, is theoretically determined by contemporary physiological and psychological studies, reflecting itself inevitably in cinematography. In this sense, hypothetical questions are imposed: What are the determinants of the relationship between the scientific study of the phenomenon of movement and film art? How to develop an analytical model of the body in motion diagram? What impact does a rapid movement in nature have on the development of cinematic expression? The analysis of locomotion, as a form of human biomechanical movement, leads to the construction of the necessary tool - the camera, implying the creation of scientific films, thereby raising the level of knowledge and observation of the phenomena of motion, transforming it into a contemporary aesthetical model of film art.

  4. ATV71变频器控制程序改进%Improvement ofATV71 converter control program

    Institute of Scientific and Technical Information of China (English)

    董云石; 周爱华

    2011-01-01

    In view of the problems in the production of packaging machines in Fuxin Daying Cement Co., Ltd.analyses were made of circuit principle of packaging machines and irrationality of circuit design was pointed out.Instrument passive contact of the original control converter was replaced by intermediate relay and the circuit was redesigned and modified. Practice shows that the modified circuits achieve the expected effect. Packaging machine switches on and off smoothly; the impact on equipment is diminished; failure rate is decreased;machines' working time is improved; operating program is simplified; equipment operating rate is improved; andworkers' labour intensity is reduced.%针对阜新大鹰水泥公司制成包装机在生产中遇到问题,对包装机的电路原理进行了分析,指出了电路设计的不合理性,采用中间继电器代替原有控制变频器的仪表无源触点,并对电路进行了重新设计修改.实践表明:改造后的电路达到了预期效果,包装机能够平稳启停机,减少了对设备的冲击,故障率下降,台时明显提高,同时简化了操作程序,提高了设备的运转率,减少了工人的劳动强度.

  5. 水电规划对四川宁南俱乐河流域两栖爬行动物的影响及对策%On Influence of Hydropower Planning on Amphibians and Reptiles in Ningnan County of Sichuan Jule River and its and Countermeasures

    Institute of Scientific and Technical Information of China (English)

    李海涛

    2012-01-01

    A survey of amphibians and reptiles of Jule River in Ningnan County, Sichuaaa Province, owing to the recently State - approved hydropower planning, by using the line statistics and data on the basis of statistics and analy- sis, has been conducted. The results show, there exist 3 sections, 14 branches, and 26 species of amphibians and rep- tiles in this area, among which amphibians are 2 sections, 9 branches, and 14 species, and reptiles 1 section, 5branches, and 12 species, with the distribution of Indomalaya and its pattern of Himalaya - Hengduan Mountains. As to the eco - characteristics of amphibians, their distribution is balanced by classifying the eco - environments as run- ning water, still water, and lands including land - running water, land -still water) ; and forest land, shrubs, grasses and farmland for reptiles, and shrubs and grasses are the major. This paper forecasts the effects of hydropower planning to amphibians and reptiles in this area. outs forward relevant countermeasures.%四川宁南县俱乐河流域近期被国家批准进行水电规划,为此我们对该流域的两栖爬行动物作了专项调查。采用线路统计法,统计与分析采集的数据。结果表明,该流域共发现两栖爬行动物3目14科26种,其中两栖类动物有2目9科14种,爬行类动物1目5科12种;该流城内两栖爬行动物均为东洋界种类的分布,分布类型以喜马拉雅一横断山区型为主。根据流域两栖类栖息的生态特点,其生态环境划分为流水、静水、陆地(含陆地一流水、陆地一静水)等,分布的种类较为均衡;爬行类栖息的生态环境划分为林地、灌草丛、田地等,其中灌草丛生态类型是该流域爬行类主要的分布区域。该文预测分析了该流域水电规划对两栖爬行动物的影响,提出了相应的保护对策。

  6. Orbital Debris Quarterly News. Volume 13; No. 1

    Science.gov (United States)

    Liou, J.-C. (Editor); Shoots, Debi (Editor)

    2009-01-01

    Topics discussed include: new debris from a decommissioned satellite with a nuclear power source; debris from the destruction of the Fengyun-1C meteorological satellite; quantitative analysis of the European Space Agency's Automated Transfer Vehicle 'Jules Verne' reentry event; microsatellite impact tests; solar cycle 24 predictions and other long-term projections and geosynchronus (GEO) environment for the Orbital Debris Engineering Model (ORDEM2008). Abstracts from the NASA Orbital Debris Program Office, examining satellite reentry risk assessments and statistical issues for uncontrolled reentry hazards, are also included.

  7. Electrical futures past.

    Science.gov (United States)

    Gooday, Graeme J N

    2005-12-01

    Futurist writing about technology emerged in the late 19th century at the same time as new kinds of electrical technology were making utopian futures seem practically attainable. Electrical writers and novelists alike thus borrowed from the popular "science" fiction of Jules Verne, Edward Bellamy and others to try to create self-fulfilling prophecies of a future in which electrical gadgets and machines met all major practical needs of civilization. To the extent that many parts of our world are populated by the hardware that they forecast, they succeeded in their goal.

  8. Librarians are vicious monsters, but canalso recommend a good read : En analys av alternativa bibliotekarieframställningar iscience fiction-litteratur

    OpenAIRE

    Österman Solborg, Amanda

    2014-01-01

    Uppsatsens syfte är att studera framställningar av manliga bibliotekarier i science fiction-litteratur, analysera vad dessa framställningar förmedlar för föreställningar om bibliotek och biblioteksverksamhet, samt att analysera de manliga bibliotekariernas koppling till maskuliniteter. Titlarna som analyseras är fyra romaner; Audrey Niffeneggers Tidsresenärens hustru, Dmitrij Gluchovskijs Metro 2033, Jules Vernes Paris i tjugonde seklet, och Jasper Ffordes Uppslukad – En fängslande historia o...

  9. Development and optimization of FJP tools and their practical verification

    Science.gov (United States)

    Messelink, Wilhelmus A. C. M.; Waeger, Reto; Meeder, Mark; Looser, Herbert; Wons, Torsten; Heiniger, Kurt C.; Faehnle, Oliver W.

    2005-09-01

    This article presents the recent achievements with Jules Verne, a sub-aperture polishing technique closely related to Fluid Jet Polishing [1]. Whereas FJP typically applies a nozzle stand-off distance of millimeters to centimeters, JV uses a stand-off distance down to 50 μm. The objective is to generate a non-directional fluid flow parallel to the surface, which is specifically suited to reduce the surface roughness [2, 3]. Different characteristic Jules Verne nozzle geometries have been designed and numerically simulated using Computational Fluid Dynamics (CFD). To verify these simulations, the flow of fluid and particles of these nozzles has been visualized in a measurement setup developed specifically for this purpose. A simplified JV nozzle geometry is positioned in a measurement setup and the gap between tool and surface has been observed by an ICCD camera. In order to be able to visualize the motion of the abrasives, the particles have been coated with fluorescence. Furthermore, these nozzles have been manufactured and tested in a practical environment using a modified polishing machine. The results of these laboratory and practical tests are presented and discussed, demonstrating that the CFD simulations are in good agreement with the experiments. It was possible to qualitatively predict the material removal on the processed glass surface, due to the implementation of appropriate erosion models [4, 5] in the CFD software.

  10. Bernard Grall, Économie de forces et production d’utilités. L’émergence du calcul économique chez les ingénieurs des Ponts et Chaussées (1831-1891, manuscrit révisé et commenté par François Vatin, Rennes, Presses universitaires de Rennes, 2004, 28 euros.Jean-Pascal Simonin, François Vatin (dir., L’œuvre multiple de Jules Dupuit (1804-1866. Calcul d’ingénieur, analyse économique et pensée sociale, Angers, Presses universitaires d’Angers, 2002, 15,25 euros.

    Directory of Open Access Journals (Sweden)

    Pierre Crépel

    2005-09-01

    Full Text Available Jules Dupuit, dont on commémore le bicentenaire en 2004, est la figure centrale de ces deux ouvrages : comme personnage étudié en tant que tel sous de multiples facettes, dans le second ; aux côtés de nombre de ses collègues de l’École des ponts et chaussées, dans le premier. Dans l’un et l’autre cas, les auteurs se penchent sur les interactions entre les activités concrètes de l’ingénieur et la construction de ses théories économiques, leurs formalisations au XIXe siècle. Les liens entre méc...

  11. Legio Vernácula, ¿Iusta Legió?

    Directory of Open Access Journals (Sweden)

    José Manuel ROLDÁN HERVÁS

    2009-10-01

    Full Text Available Según los puntos de vista de la moderna investigación se está casi unánimemente de acuerdo en que, durante la tardía república y gran parte del Alto Imperio, se cumple el principio de que las legiones han de estar formadas necesariamente por ciudadanos romanos. Este principio es el resultado final de una larga evolución que comienza a partir del siglo IV a. de C. y que se gesta al compás de la preponderancia que toma la ciudad del Tiber en el Mediterráneo. Durante la misma, en el sencillo y esquemático ejército ciudadano del siglo V a. de C. se habían ido incluyendo paulatinamente elementos de distintas procedencias: primero, las ciudades latinas; luego, los pueblos itálicos; finalmente, los subditos de las provincias que la política de expansión imperialista, abierta en las guerras púnicas y continuada sin unas claras metas fijas a lo largo de los siglos II y I a. de C, había ido ganando a lo largo de las costas del Mediterráneo. Esta inclusión no se realizó en pie de igualdad. Frente a las formaciones de infantería pesada, las legiones, que constituyen el núcleo decisivo táctico, se alinean contingentes de caballería e infantería ligera, las alae, divididas en un impreciso número de cohortes, cuya misión en el combate se reduce a la secundaria tarea de abrir el fuego y apoyar el ataque de los elementos ciudadanos legionarios. En correspondencia con estos distintos papeles, las legiones están reservadas a los ciudadanos romanos; en los auxilia, en cambio, se incluyen el resto de los elementos ligados a Roma como aliados o subditos. Circunstancias políticas de una parte, y evolución de la técnica militar, de otra, ayudarán a perfilar este esquema hasta llegar a la forma eficaz con que lo encontramos a finales de la república. De un lado, una vez que las leges lulia y Vlautia-Papiria de 89 pusieron término a los graves disturbios que sacudieron a la península Itálica a finales de la década del 90, se abren al elemento itálico, a lo que les da derecho su nueva categoría de ciudadanos, dejando con ello de servir entre los efectivos auxiliares. Estos se nutrirán a partir de este momento sólo de los subditos provinciales peregrinos, encuadrados, tras la serie de experiencias bélicas del siglo I a. de C, en unidades de caballería e infantería ligera, designadas respectivamente con los nombres de alae, subdivididas en turmae, y cohortes.

  12. Vernõi rõtsar nevernoi professii / Kirill Lavrov ; interv. Ella Agranovskaja

    Index Scriptorium Estoniae

    Lavrov, Kirill

    2006-01-01

    Peadselt saab Tallinnas Georgi Tovstonogovi nim. Suure Draamateatri esituses näha Ronald Harwoodi "Kvartetti", kus osalevad vene näitlejad Alissa Freindlihh, Kirill Lavrov, Oleg Basilashvili ja Zinaida Sharko. Telefoniintervjuu andis teatri peanäitejuht Kirill Lavrov

  13. The mystery of the seven spheres how homo sapiens will conquer space

    CERN Document Server

    Bignami, Giovanni F

    2015-01-01

    In this book, Giovanni Bignami, the outstanding Italian scientist and astronomer, takes the reader on a journey through the “seven spheres”, from our own planet to neighboring stars. The author offers a gripping account of the evolution of Homo Sapiens to the stage where our species is developing capabilities, in the form of new energy propulsion systems, that will enable us to conquer space. The reader will learn how we first expanded our activities to reach beyond our planet, to the Moon, and how nuclear energy, nuclear fusion, and matter–antimatter annihilation will enable us to extend our exploration. After Mars and Jupiter we shall finally reach the nearest stars, which we now know are surrounded by numerous planets, some of which are bound to be habitable. The book includes enticing descriptions of such newly discovered planets and also brings alive key historical characters in our story, such as Jules Verne and Werner von Braun.

  14. Preliminary study of disc hydrodynamic polishing.

    Science.gov (United States)

    Li, Yan; Lin, Bin; Zhang, XiaoFeng; Liu, PengFei

    2016-10-01

    In this paper, a developed polishing method based on elastic emission machining and Jules Verne-a variation on fluid jet polishing-is presented. This method is named disc hydrodynamic polishing (DHDP). A computational fluid dynamics (CFD)-based model that consists of a CFD model and an erosion model is introduced to predict the surface roughness obtained by DHDP. The performance of DHDP is studied by experiments. The slurry used in the experiments comprises 95% deionized water and 5% cerium oxide particles. Fused-silica glass is chosen as the workpiece. After the experiments, an ultrasmooth surface without cracks is obtained. The simulation results principally coincide with the experimental results. The experimental results show that the actual roughness is slightly less than the prediction and smaller particles are more favorable for obtaining a better surface roughness.

  15. Man and the moon—The history of lunar exploration

    Science.gov (United States)

    Mueller, George E.

    This paper delineates historical events and publications representing the human desire for exploring the Moon. Astronomers such as J. Kepler and H. Pickering were early promotors of the idea to reach out for the Moon. Many writers (Lucian, Goodwin, Cyrano de Bergerac, Jules Verne, H. G. Wells) were fascinated by the possibility of travel to the Moon. The beginning of the space age in 1957 saw early attempts to place a man-made object on the surface of the Moon, which succeeded in September 1959. Soft landers provided the first hard information on the lunar surface in the years 1966 -1968 to be followed by six manned landings in the years 1969-1972 providing a wealth of data of our neighbouring planet. Very little has happened in the years thereafter. The time has come to return to the Moon first with unmanned polar satellites to be followed by man to stay there for good.

  16. The body's tailored suit: Skin as a mechanical interface.

    Science.gov (United States)

    Tissot, Floriane S; Boulter, Etienne; Estrach, Soline; Féral, Chloé C

    2016-11-01

    Skin, by nature, is very similar to the Rouquayrol-Denayrouze suit mentioned by Jules Verne in Twenty Thousand Leagues Under the Sea: it allows "to risk (…) new physiological conditions without suffering any organic disorder". Mechanical cues, to the same extent as other environmental parameters, are such "new physiological conditions". Indeed, skin's primary function is to form a protective barrier to shield inner tissues from the external environment. This requires unique mechanical properties as well as the ability to sense mechanical cues from the environment in order to prevent or repair mechanical damages as well as to function as the primary mechanosensory interface of the whole body. Copyright © 2016 Elsevier GmbH. All rights reserved.

  17. The Brick Moon

    Science.gov (United States)

    2004-01-01

    Science fiction writers, like Jules Verne in France and Edward Everett Hale in America, had discovered one of the most vital elements in the formula for space travel-a fertile imagination. The first known proposal for a marned-satellite appears in a story by Hale entitled 'The Brick Moon' published in 1899. The story involved a group of young Bostonians who planned to put an artificial satellite into polar orbit for sailors to use to determine longitude accurately and easily. They planned to send a brick satellite into orbit because the satellite would have to withstand fire very well. The Satellite's 37 inhabitants signaled the Earth in morse code by jumping up and down on the outside of the satellite.

  18. The Brick Moon

    Science.gov (United States)

    2004-01-01

    Science fiction writers, like Jules Verne in France and Edward Everett Hale in America, had discovered one of the most vital elements in the formula for space travel-a fertile imagination. The first known proposal for a marned-satellite appears in a story by Hale entitled 'The Brick Moon' published in 1899. The story involved a group of young Bostonians who planned to put an artificial satellite into polar orbit for sailors to use to determine longitude accurately and easily. They planned to send a brick satellite into orbit because the satellite would have to withstand fire very well. The Satellite's 37 inhabitants signaled the Earth in morse code by jumping up and down on the outside of the satellite.

  19. La Fortification de Troyes en Champagne. Un grand chantier urbain Fin XVe–première moitié du XVIe siècle

    Directory of Open Access Journals (Sweden)

    Brice Collet

    2011-05-01

    Full Text Available Composition du JuryMonsieur Patrick Boucheron, maître de conférence à l’Université de Paris I,Madame Odette Chapelot, maître de conférence à l’ÉHESS,Monsieur Jean Chapelot, directeur de recherche au CNRS (directeur de la thèse,Monsieur Nicolas Faucherre, professeur à l’Université de Nantes,Monsieur Etienne Hamon, professeur à l’Université de Picardie–Jules Verne,Monsieur Pierre Monnet, directeur d’études à l’ÉHESS.Thèse soutenue le 16 décembre 2010RésuméIl ne reste actuellement plus rien ou ...

  20. Por la liberación del niño... Jules Vallès

    Directory of Open Access Journals (Sweden)

    Manuela SAN MIGUEL

    2009-08-01

    Full Text Available Discutible es, sin duda, el valor literario intrínseco de la «novela negra» de finales del XVIII, que a menudo hacía de los niños protagonistas de terroríficos relatos, increíbles y absurdamente encadenados. Baste citar como ejemplos «Victor ou l'enfant de la forêt» y «Coeline ou l'enfant du mystère». Sin embargo es indiscutible la influencia que sobre los escritores franceses del XIX ejerció este género menor, que no solo leyó con fruición un gran novelista como Mérimée, sino que sirvió de fuente de inspiración al «monstruo» de las letras francesas y gran héroe nacional, el gran Hugo, en alguno de sus primeros ensayos novelísticos: «Bug-Jargal» y «Hans d'Islande».

  1. Jules Horowitz Reactor Project- Fuel irradiation device, innovative instrumentation proposal for experimental phenomena real time measurement

    Energy Technology Data Exchange (ETDEWEB)

    Gaillot, Stephane; Cheymol, Guy [CEA, Paris (France)

    2013-07-01

    The fuel irradiation devices used for the tests or rods allow reproducing at small scales the conditions of the studied nuclear reactors (as LWR type). During the irradiation phase, the tested fuel rod can be stressed due to thermal, mechanical, nuclear effects which can modify its geometry (dilatation, swelling effects). After the test, the return to normal conditions can have as consequence the disappearance of the phenomenon or give access to partial information (final deformation). Generally, to follow the phenomena related to the irradiation phase, the experimental rod contained in the test device is instrumented with thermocouples and LVDT. As complement of this instrumentation, new sensors using innovating technologies are studied (deformation sensor integrating optical fibres). Through the example of a fuel irradiation device foreseen for the JHR, this paper aims to describe the present development of an innovating instrumentation with the objective to measure, in real time and under flux, the fuel rod deformation phenomena during a ramp test.

  2. The role of history in teaching science — A case study

    Science.gov (United States)

    Hendrick, Robert M.

    1992-06-01

    One of the most interesting aspects of late-nineteenth-century France was the extraordinary interest the public expressed in science. Its adulation of Pasteur was only one of the many manifestations of this interest. It was also expressed in the widespread popularity of scientists as public figures and in the increasing public and private financial support of science. While popularity of science was created in the general public by fiction and by the various international ‘world fairs’ held in Paris, it was strongest and most important in the middle classes. This paper examines one of the key methods used to stimulate bourgeois interest in science in France during the Second Empire and early Third Republic (1852 1895): the campaign to create a science vulgarisée, a popularized science. While a number of different approaches used by these popularizers are examined, the article concentrates on the ‘science writings’ of Jules Michelet and Jules Verne, both of whom were immensely successful in creating a favorable climate of opinion for French science. The article concludes by suggesting how such an approach could be modernized and utilized in order to create greater scientific literacy and a similar acceptance by the public today.

  3. El diseño de tipos vernáculos en Brasil y las tecnologías digitales

    OpenAIRE

    Lena Farias, Priscila

    2012-01-01

    El diseño de tipos es una actividad relativamente nueva en Brasil. Su práctica se ha incrementado desde finales de 1980, como resultado de la difusión de las tecnologías digitales. De manera paralela al fenómeno de creación tipográfica, se desarrolló en el diseño gráfico una tendencia que se caracteriza por la incorporación de formas y estilos inspirados en objetos y prácticas populares, manifestaciones gráficas previas al surgimiento de las modernas escuelas de diseño; esta tendencia se ha d...

  4. Literatura de explorações e aventuras: as "viagens extraordinárias" de Júlio Verne

    OpenAIRE

    Amorim Filho, Oswaldo Bueno

    2008-01-01

    O forte desenvolvimento dos estudos humanistas-culturais, na geografia mundial, nas últimas décadas facilitou um novo florescimento de uma antiga colaboração entre geografia e literatura. O presente ensaio introdutório busca resgatar uma das manifestações literárias mais próximas da geografia, ou seja, a "literatura de viagens, explorações e aventuras". Esta literatura teve seu apogeu na Europa do século XIX, especialmente na Alemanha, no Reino Unido e na França. Neste último país, o escritor...

  5. Imágenes del autor en la literatura vernácula medieval: el caso de la narrativa anglonormanda

    OpenAIRE

    Dumas, María

    2015-01-01

    El surgimiento del autor suele considerarse una innovación del Renacimiento, particularmente, de Francesco Petrarca, quien, a diferencia de la mayoría de los poetas medievales, busca inscribirse de manera recurrente qua individuo en su obra. La distanci

  6. Cancillería castellana y lengua vernácula : su proceso de consolidación

    Directory of Open Access Journals (Sweden)

    Pilar Ostos Salcedo

    2004-01-01

    Full Text Available La utilización de la lengua romance en la cancillería regia castellana fue resultado de un paulatino proceso que puede rastrearse a través de los numerosos documentos conservados y en los que se aprecia cómo se fue imponiendo al latín en función del contenido de los documentos y de su tipología. Los primeros indicios claros se detectan en la última etapa del reinado de Alfonso VIII, es decir, a finales del siglo XII y primeros años de la centuria siguiente. Su avance es incontestable en la época de Fernando III y en especial a partir de 1230. El triunfo del castellano en la documentación real — también notarial— se produce en la segunda mitad del siglo XIII, en el decisivo reinado de Alfonso X.The use of the Romance language in the Castilian royal Chancellory was the result of a progressive process tracked through many documents preserved, and in which it is observed how it was imposing to the latin, according to the documents contents and their typology. The first clear signs are detected during the last years of the kingdom of Alphonse VII, that is to say, at the end of the 12th century, and during the first years of the following century. Its advance is unquestionable during Ferdinand III, and specially since 1230. The success of the Castilian language in the royal documentation —also in the notarial— happens in the second half of the 13th century, during the decisive kingdom of Alphonse X.

  7. Sewage sludge up-to-date 1. Selected papers of the 2nd ATV-DVWK meeting on sewage sludge; Klaerschlamm aktuell 1. Ausgewaehlte Beitraege der 2. ATV-DVWK-Klaerschlammtage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Efficient cleaning of waste water does inevitably result in the formation of residual substances, the so-called sewage sludge. The more intensively waste water is purified the more is the amount of sludge at the end of the purification process. In the past, most of these residual substances were used in agriculture, according to the principles of an economical cycle. The progress relating pre-treatment, collection and also purification of waste waters has undoubtedly lead to an improvement of the quality of the sewage sludge thus making its utilization in agriculture senseful in many cases. In addition to the ever-lasting discussion about the pros and cons of utilizing sewage sludge, the book also deals with new aspects conditioning, thickening, dehydration, drying and burning of sewage sludge. Special attention is paid to the costs of the individual processes and examples. This brochure gives appropriate information about this subject. The advantages and disadvantages are shown and the problems relating to hazardous substances are also shown in an objective manner. The goal is to inform not only the operators of treatment plants but also the politicians and to give meaningful support in making decisions regarding the disposal of sewage sludge. [German] Wirkungsvolle Reinigung von Abwaessern fuehrt zwangslaeufig zur Bildung von Reststoffen, dem vielzitierten Klaerschlamm. Und je intensiver Abwasser gereinigt wird, um so groesser sind die Mengen an Klaerschlamm die anfallen. In der Vergangenheit sind diese Rueckstaende nach dem sinnvollen Prinzip der Kreislaufwirtschaft in grossem Mass in der Landwirtschaft eingesetzt worden. Unbestritten ist der Fortschritt in der Vorbehandlung, Sammlung und auch Reinigung der Abwaesser im Hinblick auf eine Verbesserung der Klaerschlammqualitaet, so dass einer Wiederverwendung in vielen Faellen auch heute nichts entgegensteht. Neben der immer waehrenden Diskussion um das Fuer und Wider der stofflichen Klaerschlammverwertung werden auch die neuen Aspekte der Klaerschlammkonditionierung, -eindickung, -entwaesserung, -trocknung und -verbrennung dargestellt. Dabei wird ein besonderes Augenmerk auf die Frage der Kosten der einzelnen Prozesse und Beispiele gelegt. Mit der vorliegenden Broschuere wird sachgerecht ueber das Thema informiert. Sie zaehlt Vor- und Nachteile auf und stellt vor allem das Thema Schadstoffproblematik objektiv dar. Ziel ist nicht nur, die Klaeranlagenbetreiber, sondern auch die Politiker zu informieren und sinnvolle Entscheidungshilfen zur Klaerschlammentsorgung zu geben. (orig.)

  8. About Jules et Jim: Some Figures of Matriarchy from Bachofen to Truffaut via Benjamin, Roché and Hessel

    Directory of Open Access Journals (Sweden)

    Michael Hollington

    1997-05-01

    Full Text Available Cet article essaie de relever quelques aspects d'un mouvement de pensée « matriarcale » du XXe siècle, parfois plutôt souterrain, et de montrer dans quelle mesure cette pensée fait partie du contexte du grand film des années soixante de François Truffaut. Il s'agit des hypothèses de Johann Jakob Bachofen (1815-1887, juriste et archéologue suisse, qui proposait la théorie d'un matriarcat primitif à l'origine de la société humaine. Dans un premier temps, en Méditerranée par exemple, existait selon lui un système communiste où l'idée de propriété privée était absente, fondé sur l'« hétaïrisme », où les rapports sexuels, organisés selon les vœux des femmes, étaient complètement libres.The purpose of this paper is, first, to provide a brief sketch map of a comparative nature of some linked, formative appropriations in Germany and elsewhere in the early part of this century of the Swiss jurist and archaeologist Johann Jakob Bachofen (1815-1887, famous for his influential but controversial theory of the precedence of primitive matriarchy over patriarchy in the Mediterranean and elsewhere.Este artίculo trata de señalar algunos aspectos de una corriente de pensamiento "matriarcal" del siglo veinte, a veces más bien subterránea, y muestra en qué medida dicho pensamiento forma parte del contexto de la famosa película de los años sesenta de François Truffaut. Se trata de las hipótesis de Johann Jakob Bachofen (1815-1887, jurista y arqueólogo suizo, quien propuso la teoría de un matriarcado primitivo en el origen de la sociedad humana. En un primer momento, en la región mediterránea, por ejemplo, dice que existía un sistema comunista carente de la idea de propiedad privada, y basado en el "hetaerismo", en el que las relaciones sexuales, organizadas según el voto de las mujeres, eran completamente libres.

  9. Understanding Green Flashes

    Science.gov (United States)

    Young, Andrew T.

    1998-05-01

    Most astronomers learn about green flashes from either Minnaert's old book (Dover, 1954) or O'Connell's ``The Green Flash....'' Both have defects. Minnaert's account mostly represents what was known in the 1920s; it repeats Mulder's 3-fold classification, which omits Joule's second type of flash --- the one most commonly seen from mountain observatories. O'Connell searched only the astronomical literature, missing Dietze's crucially important paper (Z.f.Met. 9, 169 (1955)) showing that the ``textbook'' mechanism cannot produce flashes visible to the naked eye. He also erred in thinking that distortions of the setting Sun arise in the upper atmosphere (they are due to the marine boundary layer), and copied an error from Feenstra Kuiper's thesis that misidentified a common mirage-like phenomenon as Wegener's ``blank strip'' (Young et al., Appl. Opt. 36, 2689 (1997).) Most phenomena shown in O'Connell's book are caused by inversion layers below eye level, not above as in Wegener's phenomenon. The two commonest forms of green flash are associated with the inferior mirage and the mock mirage, corresponding to Fisher's Type A and Type B sunsets, respectively. Superrefraction, advocated by Wood and by Rayleigh as the cause of large flashes, actually suppress them: the airmass is proportional to the refraction (by Laplace's extinction theorem), so no green is transmitted when refraction is much larger than average. Although there is a physical green flash that can be photographed, the colors seen at sunset are strongly modified by bleaching of the L cones. Most ``green'' sunset flashes are actually yellow. Writers should stop representing Jules Verne's ``ancient legend'' as fact, as it was invented by Verne as a plot device for his novel ``Le Rayon Vert.'' Green-flash photos and simulations will be shown. This material is based upon work supported by the NSF under Award No. ATM-9714357.

  10. United States Human Access to Space, Exploration of the Moon and Preparation for Mars Exploration

    Science.gov (United States)

    Rhatigan, Jennifer L.

    2009-01-01

    In the past, men like Leonardo da Vinci and Jules Verne imagined the future and envisioned fantastic inventions such as winged flying machines, submarines, and parachutes, and posited human adventures like transoceanic flight and journeys to the Moon. Today, many of their ideas are reality and form the basis for our modern world. While individual visionaries like da Vinci and Verne are remembered for the accuracy of their predictions, today entire nations are involved in the process of envisioning and defining the future development of mankind, both on and beyond the Earth itself. Recently, Russian, European, and Chinese teams have all announced plans for developing their own next generation human space vehicles. The Chinese have announced their intention to conduct human lunar exploration, and have flown three crewed space missions since 2003, including a flight with three crew members to test their extravehicular (spacewalking) capabilities in September 2008. Very soon, the prestige, economic development, scientific discovery, and strategic security advantage historically associated with leadership in space exploration and exploitation may no longer be the undisputed province of the United States. Much like the sponsors of the seafaring explorers of da Vinci's age, we are motivated by the opportunity to obtain new knowledge and new resources for the growth and development of our own civilization. NASA's new Constellation Program, established in 2005, is tasked with maintaining the United States leadership in space, exploring the Moon, creating a sustained human lunar presence, and eventually extending human operations to Mars and beyond. Through 2008, the Constellation Program developed a full set of detailed program requirements and is now completing the preliminary design phase for the new Orion Crew Exploration Vehicle (CEV), the Ares I Crew Launch Vehicle, and the associated infrastructure necessary for humans to explore the Moon. Component testing is well

  11. Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database

    Directory of Open Access Journals (Sweden)

    Liabeuf S

    2014-04-01

    Full Text Available Sophie Liabeuf,1–3 Valérie Gras,1 Julien Moragny,1 Marie-Laure Laroche,4 Michel Andrejak1,3On behalf of the French National Network of Pharmacovigilance Centers1Regional Pharmacovigilance Center, Division of Clinical Pharmacology, Amiens University Medical Center and Jules Verne University of Picardy, Amiens, France; 2Clinical Research Centre, Clinical Pharmacology Division, Amiens University Medical Center and the Jules Verne University of Picardy, Amiens, France; 3INSERM U1088, Amiens, France; 4Regional Pharmacovigilance Center, Department of Pharmacology, Toxicology and Pharmacovigilance, Limoges University Medical Center, Limoges, FranceObjective: To report a series of cases of ulceration of the oral mucosa linked to direct contact with ferrous sulfate in elderly patients.Case summary: The first case report concerns the occurrence of widespread oral ulceration in an 87-year-old woman with Alzheimer’s disease. The ulceration extended from the side of the tongue to the floor of the mouth. No clear explanation was found and various local treatments were ineffective. Once it was realized that the ferrous sulfate tablets (given as an iron supplement were crushed prior to administration (due to the patient’s deglutition disorder, withdrawal of this treatment led to rapid resolution of the ulceration. Nine other cases of oral ulcerations associated with ferrous sulfate were identified in the French National Pharmacovigilance Database. All but one of the patients were over 80 years of age and the youngest patient (a 54-year-old had dysphagia associated with facial paralysis.Discussion: Only two other reports of oral ulceration due to ferrous sulfate have been published to date. Mucosal toxicity of ferrous sulfate (which is probably related to oxidative stress has previously been reported for the hypopharynx, the esophageal lumen, and (after inhalation of a tablet the tracheobronchial tree.Conclusion: The mucosal toxicity of ferrous

  12. Workshop on The Functional Analysis of Quantum Information Theory : a Collection of Notes Based on Lectures by Gilles Pisier, K. R. Parthasarathy, Vern Paulsen and Andreas Winter

    CERN Document Server

    Gupta, Ved Prakash; Sunder, V S

    2015-01-01

    This book provides readers with a concise introduction to current studies on operator-algebras and their generalizations, operator spaces and operator systems, with a special focus on their application in quantum information science. This basic framework for the mathematical formulation of quantum information can be traced back to the mathematical work of John von Neumann, one of the pioneers of operator algebras, which forms the underpinning of most current mathematical treatments of the quantum theory, besides being one of the most dynamic areas of twentieth century functional analysis. Today, von Neumann’s foresight finds expression in the rapidly growing field of quantum information theory. These notes gather the content of lectures given by a very distinguished group of mathematicians and quantum information theorists, held at the IMSc in Chennai some years ago, and great care has been taken to present the material as a primer on the subject matter. Starting from the basic definitions of operator space...

  13. La transformación y evolución de la vivienda vernácula en la Costa Grande del Estado de Guerrero /

    OpenAIRE

    Ascencio López, Osvaldo sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Arquitectura, presenta Osvaldo Ascencio López ; asesor Fernando Martín Juez. 243 páginas : ilustraciones. Doctorado en Arquitectura UNAM, Facultad de Arquitectura, 2009

  14. Primärprävention des plötzlichen Herztodes mit implantierbaren Cardioverter-Defibrillatoren - Vernünftig oder MADIT?

    Directory of Open Access Journals (Sweden)

    Steinwender C

    2004-01-01

    Full Text Available Mehrere in jüngerer Zeit publizierte Studien belegen die Überlegenheit des implantierbaren Cardioverter-Defibrillators gegenüber einer medikamentösen Therapie in der Primärprävention des plötzlichen Herztodes. Die Kollektive dieser Untersuchungen bestanden aus den bekannten Hochrisikopatienten im Postinfarktstadium mit höher- bis höchstgradig eingeschränkter Linksventrikelfunktion. MADIT II war die erste Studie, die auf eine aufwendige rhythmologische Risikostratifizierung verzichtete und dennoch in sämtlichen Subgruppen einen therapeutischen Benefit durch die Defibrillatortherapie nachwies. Die sich hierdurch ergebende Evidenz fand rasch Eingang in die Richtlinien der großen kardiologischen Gesellschaften. Ungelöst bleiben vorerst zwei große Probleme: 1. die Frage der Finanzierung einer Umsetzung dieser Richtlinien; 2. die weitere Strategie zur effektiven Primärprävention des plötzlichen Herztodes, da durch oben genannte Studien nur ein kleiner Prozentsatz der möglichen künftigen Opfer abgedeckt wird. Als Lösungsansatz bietet sich eine kostengünstige, auf die Erfordernisse der Primärprävention abgestimmte Defibrillator-Technologie an, die gemeinsam mit einer Vereinfachung der Implantationsprozedur die Kosteneffektivität zugunsten der Prophylaxe beeinflussen kann. Weiters müssen zusätzlich große Anstrengungen zur Identifizierung von zukünftigen Opfern des plötzlichen Herztodes vor ihrer ersten Arrhythmie-Episode unternommen werden.

  15. La normalización de la arquitectura vernácula: un debate en la España de los veinte

    OpenAIRE

    Sambricio, Carlos

    2000-01-01

    En 1908, la Sociedad Central de Arquitectos presentaba al Ayuntamiento de Madrid un informe sobre construcción de casas baratas e higiénicas y, de acuerdo con lo reflejado en la encuesta planteada por el Instituto de Reformas Sociales sobre vivienda obrera, en junio del mismo año se elevaba a las Cortes un proyecto de ley para construir casas higiénicas en cuyo preámbulo se señalaba como causas que dificultaban su edificación el alto precio de la construcción y el afán de los propietarios del...

  16. Simeprevir for the treatment of hepatitis C virus infection

    Directory of Open Access Journals (Sweden)

    Izquierdo L

    2014-08-01

    Full Text Available Laure Izquierdo,1 François Helle,1 Catherine François,1,2 Sandrine Castelain,1,2 Gilles Duverlie,1,2 Etienne Brochot1,2 1Virology Research Unit, Jules Verne University of Picardie, 2Department of Virology, Amiens University Hospital, Amiens, France Abstract: Simeprevir (TMC435, Olysio™, a second-generation hepatitis C virus (HCV protease inhibitor, has been recently approved for the treatment of genotype 1 chronic hepatitis C in combination with pegylated interferon and ribavirin. This molecule has very different characteristics from first-generation protease inhibitors. Results from trials show that simeprevir is highly effective and safe, with few adverse events. We discuss the specific features of this new treatment option for HCV infection, in terms of in vitro data, pharmacological data, and clinical trials. We also discuss the impact of Q80K polymorphism at baseline. Studies evaluating interferon-free regimens with simeprevir are ongoing. Future combinations of two or more direct-acting antiviral agents, targeting different viral enzymes and with synergistic antiviral effects, will be approved, allowing treatment of pan-genotypic HCV with optimized sustained virologic responses. Simeprevir will undoubtedly be part of future treatment strategies. Keywords: simeprevir, protease inhibitor, direct-acting antiviral agent, hepatitis C virus

  17. Key Challenges and New Trends in Battery Research (2011 EFRC Forum)

    Energy Technology Data Exchange (ETDEWEB)

    Tarascon, Jean Marie (University de Picardie Jules Verne, France)

    2011-05-26

    Jean-Marie Tarascon, Professor at the University de Picardie Jules Verne, France, was the fourth speaker in the May 26, 2011 EFRC Forum session, "Global Perspectives on Frontiers in Energy Research." In his presentation, Professor Tarascon recounted European basic research activates in electrical energy storage. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  18. A Selenological History of Lunar Poetics

    Science.gov (United States)

    von Chamier-Waite, C. T.

    2016-01-01

    The Moon. Centuries of human inquiry have engaged this mysterious object. The Moon embodies history, philosophy, cosmology, and passions; the nature of love, persecution, and our capacity for the sublime. This review considers a body of research on lunar poetics done for a series of artworks by the author. It will look at a few select writings that have profoundly influenced our epistemological, ontological, and poetic knowledge of the universe with the Moon as a central theme. Centered in the early seventeenth century at the time of Kepler and Galileo, this query follows the tendrils of lunar influences in both the sciences and literature that emanate from these two figures, forwards and backwards in time. Science, politics, theology, and the arts intertwine in this investigation. The works reviewed link the philosophy of Aristotle and the poetry of Lucian of Samosata to findings by Leonardo Da Vinci, Copernicus, Jules Verne, and others. The chosen philosophers have been selected because of their significant contributions to selenology and lunar poetics, and each of the figures reviewed have the honor of a namesake crater upon the Moon.

  19. Contested Waterlines: The Wave-Line Theory and Shipbuilding in the Nineteenth Century.

    Science.gov (United States)

    Ferreiro, Larrie D; Pollara, Alexander

    2016-04-01

    Ship hydrodynamics in the nineteenth century was dominated by John Scott Russell's wave-line theory. Russell, a prominent British shipbuilder and scientist, argued that wavemaking was the primary source of resistance for ships, and that by designing ships according to trigonometric curves and proportions (the wave line) this resistance could effectively be eliminated. From the 1840s to the 1880s, shipbuilders such as John Willis Griffiths, Donald McKay and George Steers designed their clipper ships (like Sea Witch and Flying Cloud) and yachts (America) with wave-line hulls, while authors like Jules Verne referenced Russell's theory. The wave line slowly faded after William Froude developed his laws of ship resistance. The article examines how Russell's theory became accepted by technical experts and the wider public to become the most widely known ship hydrodynamic theory of the 1800s-a reminder of how a persuasive idea can take hold of an entire profession, and even the public, for a long time.

  20. Projections of population-based twinning rates through the year 2100.

    Science.gov (United States)

    Oleszczuk, J J; Keith, D M; Keith, L G; Rayburn, W F

    1999-11-01

    To present the first compilation of population-based twinning rates published after the year 1990 and to project population-based twinning rates through the year 2100. We searched the Internet-based MEDLINE database for articles published after 1990 in which population-based twinning rates were described. We used population-based data from national statistical authorities from Australia, Austria, Canada, Finland, Hong Kong, Israel, Japan, Norway, Singapore and Sweden, published by Y. Imaizumi in a recent article. U.S. figures were based on data from the National Center for Health Statistics. Annual growth rates of twinning were calculated and graphed, making the assumption that these rates would remain constant throughout the next century. Our report presents the most recent population-based twinning rates. When projected through the year 2015, twinning rates reach figures that could best be described as derived from a Jules Verne novel: Sweden, in this model, would have four times more twin than singleton births. We strongly suggest that physicians reexamine their patterns of prescribing ovulation-inducing agents, which carry a greatly increased risk of multiple pregnancy.

  1. The Cincinnati Observatory as a Research Instrument for Undergraduate Research

    Science.gov (United States)

    Abel, Nicholas; Regas, Dean; Flateau, Davin C.; Larrabee, Cliff

    2016-06-01

    The Cincinnati Observatory, founded in 1842, was the first public observatory in the Western Hemisphere. The history of Cincinnati is closely intertwined with the history of the Observatory, and with the history of science in the United States. Previous directors of the Observatory helped to create the National Weather Service, the Minor Planet Center, and the first astronomical journal in the U.S. The Cincinnati Observatory was internationally known in the late 19th century, with Jules Verne mentioning the Cincinnati Observatory in two of his books, and the Observatory now stands as a National Historic Landmark.No longer a research instrument, the Observatory is now a tool for promoting astronomy education to the general public. However, with the 11" and 16" refracting telescopes, the Observatory telescopes are very capable of collecting data to fuel undergraduate research projects. In this poster, we will discuss the history of the Observatory, types of student research projects capable with the Cincinnati Observatory, future plans, and preliminary results. The overall goal of this project is to produce a steady supply of undergraduate students collecting, analyzing, and interpreting data, and thereby introduce them to the techniques and methodology of an astronomer at an early stage of their academic career.

  2. Around Kepler's "Dream"

    CERN Document Server

    Luminet, Jean-Pierre

    2011-01-01

    Johann Kepler (1571-1630) is sometimes considered as a precursor of science-fiction novels with the writing of "Somnium, sive opus posthumum of astronomia lunaris". In this work published posthumously in 1634 by his son Ludwig, Kepler intends to defend the Copernican doctrine by detailing the perception of the world for an observer located on the Moon. Although Kepler was not the first to write the fantastic account of a voyage from the Earth to the Moon and "pass around a message", we show here that his "Dream" is made conspicuous under many aspects. Firstly, his author is one of the most remarkable minds of the history of sciences. Secondly, the "Dream" constitutes the missing link between the texts of pure imagination by Lucian of Samosata (IInd c. AD), and the fantasy novels based on scientific discoveries by Jules Verne, at the end of XIXth century. In the third place, the complete text presents an extraordinary structure in encased accounts, built on several series of explanatory notes drafted with the ...

  3. The history of gait analysis before the advent of modern computers.

    Science.gov (United States)

    Baker, Richard

    2007-09-01

    Aristotle (384-322 BCE) can be attributed with the earliest recorded comments regarding the manner in which humans walk. It was not until the renaissance that further progress was made through the experiments and theorising of Giovanni Borelli (1608-1679). Although several scientists wrote about walking through the enlightenment period it was the brothers Willhelm (1804-1891) and Eduard (1806-1871) Weber, working in Leipzig who made the next major contribution based on very simple measurements. Both Jules Etienne Marey (1830-1904), working in France, and Eadweard Muybridge (1830-1904), working in America, made significant advances in measurement technology. These were developed further by Otto Fischer (1861-1917) in collaboration with Willhelm Braune (1831-1892). The major developments in the early twentieth century were in the development of force plates and the understanding of kinetics. The team headed by Verne Inman (1905-1980) and Howard Eberhart (1906-1993) made major advances in America shortly after the Second War. David Sutherland (1923-2006) and Jacquelin Perry pioneered clinical applications in America and Jurg Baumann (1926-2000) in Europe. It was not until the advent of modern computers that clinical gait analysis became widely available.

  4. On 23 March ESA’s third Automated Transfer Vehicle (ATV), named in honour of Amaldi, was launched on board an Ariane rocket.

    CERN Multimedia

    CERN Video Productions

    2012-01-01

    Live webcast from CERN on the occasion of the launch of a "Space Ferry", named after Edoardo Amaldi, by the European Space Agency (ESA). Amaldi was CERN's first Secretary General and founding father, and a visionary pioneer for ESA. With the participation of Ugo Amaldi, CERN physicist and son of Edoardo Amaldi, Carlo Rubbia, Nobel Laureate in Physics and Former Director General of CERN and Arturo Russo, historian and author with John Kriege of CERN and ESA's History

  5. Trails, Other, This would include horse trails, ATV Trails & cross country ski trails., Published in 2012, Not Applicable scale, Chippewa County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, Other dataset, published at Not Applicable scale, was produced all or in part from Field Observation information as of 2012. It is described as 'This...

  6. Recreational Areas, Recreational Trails, Horse, Bike Trails, Walking and ATV Trails, Published in 2008, 1:24000 (1in=2000ft) scale, Lafayette County Land Records.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Recreational Areas dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008. It is...

  7. A Trial of an All-Terrain Vehicle Safety Education Video in a Community-Based Hunter Education Program

    Science.gov (United States)

    Williams, Robert S.; Graham, James; Helmkamp, James C.; Dick, Rhonda; Thompson, Tonya; Aitken, Mary E.

    2011-01-01

    Purpose: All-terrain vehicle (ATV) injury is an increasingly serious problem, particularly among rural youth. There have been repeated calls for ATV safety education, but little study regarding optimal methods or content for such education. The purpose of this study was to determine if an ATV safety video was effective in increasing ATV safety…

  8. 博尔德(Border,Jules Jean Baptiste Vincent.1870-1961)比利时微生物学家(Microbiologist,Belgium)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    博尔德于1892年在布鲁塞尔大学获得医学博士学位,随后又到巴黎巴斯德P6研究所,在梅契尼科夫指导下工作。1901年,他在布鲁塞尔也创建了一个巴斯德研究所并亲任所长。1898年,博尔德发现,如果把血清加热到55℃,尽管血清中的抗体不致受到破坏,但却丧失了摧毁细菌的能力。由此可以推断,血清中一定含有某种或某组非常脆弱的成分作为抗体的补体,使之能够与细菌发生作用。

  9. Falquet Jules, Hirata Helena, Kergoat Danièle, Labari Brahim, Le Feuvre Nicky, Sow Fatou(Dir., Le sexe de la mondialisation

    Directory of Open Access Journals (Sweden)

    Olivier Giraud

    2011-09-01

    Full Text Available L’ouvrage Le sexe de la mondialisation – Genre, classe, race et nouvelle division du travail mérite une grande attention de la communauté académique et au-delà, pour au moins quatre raisons. En premier lieu, cet ouvrage traite d’une question essentielle pour la compréhension du monde contemporain, celle de la dimension genrée de la mondialisation. En deuxième lieu, il réunit une équipe d’auteures et auteurs francophones et autres (plus de la moitié des textes sont traduits de l’anglais de pr...

  10. Development and experimental qualification of a calculation scheme for the evaluation of gamma heating in experimental reactors. Application to MARIA and Jules Horowitz (JHR) MTR Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Tarchalski, M.; Pytel, K.; Wroblewska, M.; Marcinkowska, Z.; Boettcher, A.; Prokopowicz, R. [NCBJ Institute, MARIA Reactor, ul.Andrzeja Soltana 7, 05-400 Swierk (Poland); Sireta, P.; Gonnier, C.; Bignan, G. [CEA, DEN, Reactor Studies Department, Cadarache, F-13108 St-Paul-Lez-Durance (France); Lyoussi, A.; Fourmentel, D.; Barbot, L.; Villard, J.F.; Destouches, C. [CEA, DEN, DER, Instrumentation Sensors and Dosimetry Laboratory, Cadarache, F-13108 St-Paul-Lez-Durance (France); Reynard-Carette, C.; Brun, J. [Aix Marseille Universite, CNRS, Universite de Toulon, IM2NP UMR 7334, 13397, Marseille (France); Jagielski, J. [NCBJ Institute, MARIA Reactor, ul.Andrzeja Soltana 7, 05-400 Swierk (Poland); Institute of Electronic Materials Technolgy, Wolczynska 133, 01-919 Warszawa (Poland); Luks, A. [Institute of Heat Engineering, Nowowiejska 21/25, 00-665 Warsaw (Poland)

    2015-07-01

    Precise computational determination of nuclear heating which consists predominantly of gamma heating (more than 80 %) is one of the challenges in material testing reactor exploitation. Due to sophisticated construction and conditions of experimental programs planned in JHR it became essential to use most accurate and precise gamma heating model. Before the JHR starts to operate, gamma heating evaluation methods need to be developed and qualified in other experimental reactor facilities. This is done inter alia using OSIRIS, MINERVE or EOLE research reactors in France. Furthermore, MARIA - Polish material testing reactor - has been chosen to contribute to the qualification of gamma heating calculation schemes/tools. This reactor has some characteristics close to those of JHR (beryllium usage, fuel element geometry). To evaluate gamma heating in JHR and MARIA reactors, both simulation tools and experimental program have been developed and performed. For gamma heating simulation, new calculation scheme and gamma heating model of MARIA have been carried out using TRIPOLI4 and APOLLO2 codes. Calculation outcome has been verified by comparison to experimental measurements in MARIA reactor. To have more precise calculation results, model of MARIA in TRIPOLI4 has been made using the whole geometry of the core. This has been done for the first time in the history of MARIA reactor and was complex due to cut cone shape of all its elements. Material composition of burnt fuel elements has been implemented from APOLLO2 calculations. An experiment for nuclear heating measurements and calculation verification has been done in September 2014. This involved neutron, photon and nuclear heating measurements at selected locations in MARIA reactor using in particular Rh SPND, Ag SPND, Ionization Chamber (all three from CEA), KAROLINA calorimeter (NCBJ) and Gamma Thermometer (CEA/SCK CEN). Measurements were done in forty points using four channels. Maximal nuclear heating evaluated from measurements is of the order of 2.5 W/g at half of the possible MARIA power - 15 MW. The approach and the detailed program for experimental verification of calculations will be presented. The following points will be discussed: - Development of a gamma heating model of MARIA reactor with TRIPOLI 4 (coupled neutron-photon mode) and APOLLO2 model taking into account the key parameters like: configuration of the core, experimental loading, control rod location, reactor power, fuel depletion); - Design of specific measurement tools for MARIA experiments including for instance a new single-cell calorimeter called KAROLINA calorimeter; - MARIA experimental program description and a preliminary analysis of results; - Comparison of calculations for JHR and MARIA cores with experimental verification analysis, calculation behavior and n-γ 'environments'. (authors)

  11. Interactive Geophysical Mapping on the Web

    Science.gov (United States)

    Meertens, C.; Hamburger, M.; Estey, L.; Weingroff, M.; Deardorff, R.; Holt, W.

    2002-12-01

    We have developed a set of interactive, web-based map utilities that make geophysical results accessible to a large number and variety of users. These tools provide access to pre-determined map regions via a simple Html/JavaScript interface or to user-selectable areas using a Java interface to a Generic Mapping Tools (GMT) engine. Users can access a variety of maps, satellite images, and geophysical data at a range of spatial scales for the earth and other planets of the solar system. Developed initially by UNAVCO for study of global-scale geodynamic processes, users can choose from a variety of base maps (satellite mosaics, global topography, geoid, sea-floor age, strain rate and seismic hazard maps, and others) and can then add a number of geographic and geophysical overlays for example coastlines, political boundaries, rivers and lakes, NEIC earthquake and volcano locations, stress axes, and observed and model plate motion and deformation velocity vectors representing a compilation of 2933 geodetic measurements from around the world. The software design is flexible allowing for construction of special editions for different target audiences. Custom maps been implemented for UNAVCO as the "Jules Verne Voyager" and "Voyager Junior", for the International Lithosphere Project's "Global Strain Rate Map", and for EarthScope Education and Outreach as "EarthScope Voyager Jr.". For the later, a number of EarthScope-specific features have been added, including locations of proposed USArray (seismic), Plate Boundary Observatory (geodetic), and San Andreas Fault Observatory at Depth sites plus detailed maps and geographically referenced examples of EarthScope-related scientific investigations. In addition, we are developing a website that incorporates background materials and curricular activities that encourage users to explore Earth processes. A cluster of map processing computers and nearly a terabyte of disk storage has been assembled to power the generation of

  12. The Command of Space: A National Vision for American Prosperity and Security

    Science.gov (United States)

    2000-03-01

    This paper develops a compelling case for a national space vision to advance the American vital interests of prosperity and security. The first half of paper focuses on laying the background for the vision that follows in the second half. In the title, prosperity is listed before security since it is the reason for exploration and eventually requires protection. The paper begins with the premise that space is becoming an information center of gravity that is increasingly important to the commercial sector as well as the military. However, a major stumbling block in this transition is the lack of the means to protect on-orbit space systems. Without this capability, true command of space is not possible. The paper then transitions to a discourse on the current dependence on space in America. Next, the quest for wealth and information by the European powers in the second millennium is discussed. Each of these examples demonstrates a recurring cycle in their quest: knowledge, exploitation, investment, consumption and protection. This same cycle is seen in the early days of space where the focus was almost exclusively on knowledge and exploration. Several who possessed a vision to advance space were Jules Verne, Wernher von Braun and Arthur C. Clark. From the early days of space, the transition is made to reviewing a current focus on investment and consumption.To make the case for protecting space assets, the role of the U.S. Navy in protecting maritime commerce is examined as well as the current threat to the space sector.

  13. Study by similarity of wind influence on mass transfers in complex buildings; Etude par similitude de l'influence du vent sur les transferts de masse dans les batiments complexes

    Energy Technology Data Exchange (ETDEWEB)

    Le Roux, Nicolas

    2011-12-05

    Residential and industrial buildings equipped with a ventilation system are complex facilities, where various heat and mass transfers could occur according to the operating conditions. In order to study these mass transfers, a methodology has been developed so as to carry out reduced-scale experiments for the study of isothermal flows, in steady or transient state. This methodology has been numerically and experimentally validated on simple configurations, and then applied to two standard configurations, representing nuclear facilities. The wind influence on mass transfers inside these configurations, in normal, damaged (stopping ventilation) or accidental (internal overpressure) situations, has been studied in the Jules Verne climatic wind tunnel of the CSTB. The wind effects, coupled or not with an internal overpressure, can lead to a partial or a total loss of the pollutant's containment inside buildings. Moreover, the wind turbulence can bring about instantaneous reversal leakage flow-rates, which cannot be identified in steady state. In addition, the study of transient phenomena has highlighted the low influence of the branch inertia on transient flows, for typical values of real facilities. Finally, tracer tests have been carried out in order to study the pollutant dispersion inside a standard configuration subjected to wind, mechanical ventilation and internal overpressure effects. The reliability of the zonal code SYLVIA, used notably to support safety assessment in nuclear buildings, has been analyzed from these experimental results. The modelling of the physical phenomena experimentally observed has been validated, in steady and transient states. However, limitations have been identified for the study of pollutant dispersion, due to hypothesis used in SYLVIA code, as in all zonal codes (homogenous concentration inside rooms, instantaneous propagation inside branches and rooms). (author)

  14. The ADM-AEOLUS Solar Array

    Science.gov (United States)

    Riva, S.; Ferrando, E.; Contini, R.; Blok, R.; Heijden, R. vd; Caon, A.; Labruyere, G.; Strobl, G.; Koestler, W.; Zimmermann, W.

    2008-09-01

    ADM Aeolus is an Earth Explorer Core Mission of the European Space Agency (ESA). The satellite is provided with a deployable solar array fully equipped with European state of the art Triple Junction (TJ) GaAs solar cells.The structural part and mechanisms of the ADM Aeolus Solar Array (SA) is a derivate of the Dutch Space FRED solar array concept. This FRED type solar array has already been used on Jules Verne (Automated Transfer Vehicle) and Giove-A. Both satellites has been successfully launched and the Solar Arrays are working nominally.The ADM Aeolus spacecraft (S/C) is powered by two deployable wings. Each of them composed by three panels and with a panel size of 1.1×2.2 m2, so that the total area is about 14.5 m2;. European TJ solar cells (27% efficiency class) embodying an integral protection diode were selected to meet the power budget, necessary for the installed payload. The principal one is an Atmospheric LAser Doppler INstrument (ALADIN), a novel system whose development is a strategic goal for ESA.This SA program is a challenging development in terms of solar cell qualification because of the extensive characterisation and qualification campaign performed for the cell and the integral diode components. Especially for protection diode a long duration high temperature test was performed in order to simulate and cover all lifetime stresses.Main drivers for PVA design are the power requirement at the end of life and the requested protection against atomic oxygen erosion.This paper describes : The results achieved during the qualification phase, from bare cell level to the coupon level, The design activity, mainly focused on the prediction of EOL performances, The acceptance phase at panel levels, which has verified the suitability of the design assumption and manufacturing workmanship.

  15. Surface vector mapping of magnetic anomalies over the Moon using Kaguya and Lunar Prospector observations

    Science.gov (United States)

    Tsunakawa, Hideo; Takahashi, Futoshi; Shimizu, Hisayoshi; Shibuya, Hidetoshi; Matsushima, Masaki

    2015-06-01

    We have provided preliminary global maps of three components of the lunar magnetic anomaly on the surface applying the surface vector mapping (SVM) method. The data used in the present study consist of about 5 million observations of the lunar magnetic field at 10-45 km altitudes by Kaguya and Lunar Prospector. The lunar magnetic anomalies were mapped at 0.2° equi-distance points on the surface by the SVM method, showing the highest intensity of 718 nT in the Crisium antipodal region. Overall features on the SVM maps indicate that elongating magnetic anomalies are likely to be dominant on the Moon except for the young large basins with the impact demagnetization. Remarkable demagnetization features suggested by previous studies are also recognized at Hertzsprung and Kolorev craters on the farside. These features indicate that demagnetized areas extend to about 1-2 radii of the basins/craters. There are well-isolated central magnetic anomalies at four craters: Leibnitz, Aitken, Jules Verne, and Grimaldi craters. Their magnetic poles through the dipole source approximation suggest occurrence of the polar wander prior to 3.3-3.5 Ga. When compared with high-albedo markings at several magnetic anomalies such as the Reiner Gamma anomalies, three-dimensional structures of the magnetic field on/near the surface are well correlated with high-albedo areas. These results indicate that the global SVM maps are useful for the study of the lunar magnetic anomalies in comparison with various geological and geophysical data.

  16. Optograms and criminology: science, news reporting, and fanciful novels.

    Science.gov (United States)

    Lanska, Douglas J

    2013-01-01

    A persistent nineteenth-century urban legend was the notion that photograph-like images of the last-seen object or person would be preserved in the eyes of the dead. This popular notion followed technological developments (the daguerreotype and ophthalmoscope) that antedated by decades a basic understanding of retinal physiology. From 1876 to 1877, Boll described photochemical bleaching of the retina and produced a crude retinal image that remained briefly visible after death in an experimental animal. From 1877 to 1881, Kühne elaborated the processes involved in photochemical transduction, and created more complex retinal images, or "optograms," that were visible after the death of experimental animals under special laboratory circumstances. In 1880, Kühne reported the first human "optogram" when he examined the eyes following the state execution of a convicted murderer. Although the work of these physiologists increased public interest in "optography" as a potential tool in forensic investigations, Kühne and his student, Ayres, concluded after an extensive series of investigations that optography would never be useful for this purpose. Nevertheless, because of the prior tantalizing results, optography became a frequent consideration in speculative news reports of sensational unsolved murders, and as a plot device in works of fiction, some quite fantastical. Fictional portrayals included works by Rudyard Kipling and Jules Verne. Despite denouncement of optography for forensic investigations by Kühne, and by numerous physicians, the general public and mass media continued to press for examination of the retinae of murder victims well into the twentieth century, particularly in high-profile unsolved cases. © 2013 Elsevier B.V. All rights reserved.

  17. Global Aspects of the Exploration of Space

    Science.gov (United States)

    Dryden, Hugh L.

    1959-01-01

    The interest of man in outer space began long ago among uncivilized peoples to whom the face of the sky was clock and almanac; the celestial bodies, objects of worship. Exploration was at first by visual observation, later aided by armillary spheres and quadrants, and still later by more precise measuring instruments, telescopes, and spectroscopes. The information obtained was that borne by the light that was transmitted from the distant celestial object through the atmosphere to the observing instrument on the ground. In recent years the light waves have been supplemented by radio waves as carriers of information from the stars and planets. Men of many nations have contributed through the centuries to the exploration of space by the methods of astronomy. The history of advances in astronomical knowledge and technique includes the records of Chinese, Babylonians, Greeks, Arabians, and of nearly every nation of the modern world. International cooperation was early recognized as essential and beneficial; the countless number of the stars and the vastness of space present mankind with a truly global task. The picture of the universe obtained by the astronomers early stirred the imagination of men to speculate about the existence of life elsewhere in the universe, about means of communication with distant stars, and in the last centuries about the possibility of the travel of man to the moon and planets. Some sought to apply the science and engineering of their day to describe the vehicles to be used. For example, Jules Verne published in 1865 in "From the Earth to the Moon" a description of a gun-launched projectile carrying passengers to orbit the moon. Today we have taken the first steps to bring this inspired vision to reality. The exploration of space by unmanned vehicles carrying scientific apparatus began on October 4, 1957; exploration by man will follow in due course.

  18. The genesis of neurosurgery and the evolution of the neurosurgical operative environment: part II--concepts for future development, 2003 and beyond.

    Science.gov (United States)

    Liu, Charles Y; Spicer, Mark; Apuzzo, Michael L J

    2003-01-01

    The future development of the neurosurgical operative environment is driven principally by concurrent development in science and technology. In the new millennium, these developments are taking on a Jules Verne quality, with the ability to construct and manipulate the human organism and its surroundings at the level of atoms and molecules seemingly at hand. Thus, an examination of currents in technology advancement from the neurosurgical perspective can provide insight into the evolution of the neurosurgical operative environment. In the future, the optimal design solution for the operative environment requirements of specialized neurosurgery may take the form of composites of venues that are currently mutually distinct. Advances in microfabrication technology and laser optical manipulators are expanding the scope and role of robotics, with novel opportunities for bionic integration. Assimilation of biosensor technology into the operative environment promises to provide neurosurgeons of the future with a vastly expanded set of physiological data, which will require concurrent simplification and optimization of analysis and presentation schemes to facilitate practical usefulness. Nanotechnology derivatives are shattering the maximum limits of resolution and magnification allowed by conventional microscopes. Furthermore, quantum computing and molecular electronics promise to greatly enhance computational power, allowing the emerging reality of simulation and virtual neurosurgery for rehearsal and training purposes. Progressive minimalism is evident throughout, leading ultimately to a paradigm shift as the nanoscale is approached. At the interface between the old and new technological paradigms, issues related to integration may dictate the ultimate emergence of the products of the new paradigm. Once initiated, however, history suggests that the process of change will proceed rapidly and dramatically, with the ultimate neurosurgical operative environment of the future

  19. Breast cancer and per-operation electron radiotherapy: a review of the first 100 patients treated at the Jules-Bordet Institute; Cancer du sein et radiotherapie peroperatoire par electrons: revue des 100 premieres patientes traitees a l'institut Jules-Bordet

    Energy Technology Data Exchange (ETDEWEB)

    Philippson, C.; Simon, S.; Vandekerkhove, C.; Veys, I.; Noterman, D.; Hertens, D.; Neubourg, F. De; Larsimont, D.; Van Houtte, P.; Nogaret, J.M. [Institutjules-Bordet, Bruxelles (Belgium)

    2011-10-15

    The authors briefly discuss the results obtained on a cohort of women treated by per-operation radiotherapy for breast cancer. This technique enables a dose equivalent to that of a conventional fractionated external radiotherapy to be delivered in a single session in the tumour bed. Moreover, a weaker dose can be delivered as a boost before a conventional irradiation. Immediate morbidity is steady. Some rare complications have been noticed. Short communication

  20. Empleo del método estratigráfico en el estudio de la vivienda rural vernácula construida con tierra. Un caso de aplicación en La Rioja, Argentina

    Directory of Open Access Journals (Sweden)

    Rolón, Guillermo

    2010-12-01

    Full Text Available Earthen architecture, as being study subject, began in the last quarter of the twentieth century caused by the urgent need to preserve this type of building heritage worldwide. Nowadays, its scope has significantly increased and linked with other disciplinary fields. In this article, we present the preliminary results obtained from the study of earthen historic building by using theoretical and methodological tools developed within Archaeology of Architecture. The case herein discussed is a rural dwelling which was continuously inhabited. It was built during the second half of the nineteenth century in the valley regions in La Rioja province (Argentina. The study was jointly carried out using the wall stratigraphic method, the typology of rural housing and the analysis of different construction techniques.La Arquitectura en Tierra, como campo temático específico dentro de la disciplina de Arquitectura, renace a partir del último cuarto de siglo XX impulsada por la urgente necesidad de preservar este tipo de patrimonio construido en todo el mundo. En la actualidad, su campo de acción se ha incrementado notablemente, del mismo modo que su vinculación con otras disciplinas. En este texto exponemos los resultados previos surgidos del estudio de un edificio histórico doméstico en tierra empleando herramientas teóricas y metodológicas desarrolladas en el ámbito de la Arqueología de la Arquitectura. El caso abordado corresponde a una vivienda rural popular construida durante la segunda mitad del siglo XIX en la región de los valles de la provincia argentina de La Rioja, con continuidad de uso hasta la actualidad. El estudio fue realizado empleando conjuntamente el método estratigráfico de alzados, la tipología de vivienda rural y el análisis de las diferentes técnicas constructivas.

  1. El impacto sociocultural de la migración en la evolución de la vivienda vernácula : región de la montaña de Guerrero, 1985-2006 /

    OpenAIRE

    Jerónimo Vargas, Constantino sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Arquitectura, presenta Constantino Jerónimo Vargas ; asesor Fernando Martín Juéz. 315, [1] páginas : ilustraciones. Doctorado en Arquitectura UNAM, Facultad de Arquitectura, 2009

  2. El impacto sociocultural de la migración en la evolución de la vivienda vernácula : región de la montaña de Guerrero, 1985-2006 /

    OpenAIRE

    Jerónimo Vargas, Constantino sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Arquitectura, presenta Constantino Jerónimo Vargas ; asesor Fernando Martín Juéz. 315, [1] páginas : ilustraciones. Doctorado en Arquitectura UNAM, Facultad de Arquitectura, 2009

  3. Variações lingüísticas e suas implicações no ensino do vernáculo: uma abordagem sociolingüística

    Directory of Open Access Journals (Sweden)

    Rosa Maria Assis

    2008-04-01

    Full Text Available 0 quadro da realidade econômica brasileira evidência que a grande maioria da população pertence as camadas populares, i.e. camadas de baixo poder aquisitivo. Assim sendo, "nem é preciso buscar razões ideológicas ou politicas para concluir que a escola e, fundamentalmente, uma escola para o povo" (Soares, 1986:5. Entretanto, se por um lado não se pode negar uma já antiga preocupação do governo e de professores em busca de solução para a tão denunciada precariedade do ensino para o povo, através da democratização da escola, por outro lado, sabe-se que a escola ainda não conseguiu satisfatória e efetivamente atender a demanda das camadas populares, seja em termos qualitativos, seja em termos quantitativos. É um ensino marcado pelo fracasso, caracterizado pelo êxodo e pelo alto indice de repetência, sem falar no problema estigmatizador do analfabetismo que, em certas regiões, chega a um percentual médio de 60%.

  4. Sobre los Marginalia en la Carta Apologética (1735 de Manuel Fernández Sidrón: Lecturas en latín y vernáculo de un franciscano canario

    Directory of Open Access Journals (Sweden)

    Salas Salgado, Francisco

    2009-12-01

    Full Text Available The quality of records of all sorts regarding the type of books found in the libraries of the Canary Islands is enriched on some occasions by the inclusion of precise references to specific works. Such is the case of the Apologetic Letter (1735, by the Franciscan Manuel Fernández Sidrón. The aim of this work is to analyze the margins of this letter, where a considerable amount of quotations and references to authors and works can be appreciated. Althought the acceptance of a particular aim for these references is taken for granted, the marginal quotations disclose a whole world of books revealing not only the personal readings and tastes of the author, but also more general interests.A los registros de diverso tipo que existen sobre los libros que conformaron muchas bibliotecas en Canarias, se añade la referencia precisa que en determinadas obras se puede encontrar. Es el caso de la Carta apologética (1735, obra debida al franciscano Manuel Fernández Sidrón, en cuyos márgenes existe todo un cúmulo de citas de autores y obras, del cual va a tratar el siguiente trabajo. Aunque es lógico considerar que esta obra tiene unos fines concretos, estas citas marginales descubren un universo de libros que no sólo tienen que ver con unos gustos de lecturas particulares, sino también generales.

  5. Spectrophotometric method for simultaneous estimation of atazanavir sulfate and ritonavir in tablet dosage form

    OpenAIRE

    Disha A Patel; Bhavini N Patel; Patel, Chhaganbhai N.

    2015-01-01

    Background: Ritonavir (RTV) and atazanavir sulfate (ATV) are protease inhibitor and RTV mostly used as a booster for increasing the bioavailability of other protease inhibitors like ATV. Aims: Quality assessment of the new dosage form of RTV and ATV i.e., tablets is very essential and hence this work deals with to develop sensitive, simple and precise method for simultaneous estimation of ATV and RTV in tablet dosage form by absorbance correction method. Materials and Methods: The present wor...

  6. All-Terrain Vehicle Safety and Use Patterns in Central Illinois Youth

    Science.gov (United States)

    Hafner, John W.; Hough, Scott M.; Getz, Marjorie A.; Whitehurst, Yvette; Pearl, Richard H.

    2010-01-01

    Context: All-terrain vehicles' (ATVs) popularity and associated injuries among children are increasing in the United States. Currently, most known ATV use pattern data are obtained from injured youth and little documented data exist characterizing the typical ATV use patterns and safety practices among American children in general. Purpose: To…

  7. Metabolic and kidney disorders correlate with high atazanavir concentrations in HIV-infected patients: is it time to revise atazanavir dosages?

    Directory of Open Access Journals (Sweden)

    Cristina Gervasoni

    Full Text Available Ritonavir-boosted atazanavir (ATV/r is a relatively well tolerated antiretroviral drug. However, side effects including hyperbilirubinemia, dyslipidemia, nephrolithiasis and cholelithiasis have been reported in the medium and long term. Unboosted ATV may be selected for some patients because it has fewer gastrointestinal adverse effects, less hyperbilirubinemia and less impact on lipid profiles.We investigated the distribution of ATV plasma trough concentrations according to drug dosage and the potential relationship between ATV plasma trough concentrations and drug-related adverse events in a consecutive series of 240 HIV-infected patients treated with ATV/r 300/100 mg (68% or ATV 400 mg (32%.43.9% of patients treated with ATV/r 300/100 mg had ATV concentrations exceeding the upper therapeutic threshold. A significant and direct association has been observed between the severity of hyperbilirubinemia and ATV plasma trough concentrations (ATV concentrations: 271 [77-555], 548 [206-902], 793 [440-1164], 768 [494-1527] and 1491 [1122-1798] ng/mL in patients with grade 0, 1, 2, 3 and 4 hyperbilirubinemia, respectively. In an exploratory analysis we found that patients with dyslipidemia or nephrolitiasis had ATV concentrations significantly higher (582 [266-1148], and 1098 [631-1238] ng/mL, respectively (p<0.001, as compared with patients with no ATV-related complications (218 [77-541] ng/mL.A significant proportion of patients treated with the conventional dosage of ATV (300/100 had plasma concentrations exceeding the upper therapeutic threshold. These patients that are at high risk to experience ATV-related complications may benefit from TDM-driven adjustments in ATV dosage with potential advantages in terms of costs and toxicity.

  8. 从艾儒略到朱自清:游记与"浪漫法兰西"形象的生成%From Jules Aleni to Zhu Ziqing: On Travel Netes and Creation of the Image of Romantic France in China

    Institute of Scientific and Technical Information of China (English)

    孟华

    2006-01-01

    什么词最能概括现代中国人心目中的法国形象?大多数人选择"浪漫"一词.但若再深问一句:法国何以是浪漫的?答案莫衷一是.本文认为,"浪漫法兰西"形象的起源始自法国神甫艾儒略的游记在中国的译介.张德彝和王韬追随艾儒略,现当代作家又追随张德彝和王韬,现代中国人心目中的"浪漫法兰西"形象就是在这种"同质"与"异质"的"互文"中构成的.

  9. 从艾儒略到朱自清:游记与"浪漫法兰西"形象的生成%From Jules Aleni to Zhu Ziqing:Travel accounts and the construction of "Romantic France"

    Institute of Scientific and Technical Information of China (English)

    孟华

    2008-01-01

    Many Chinese believe that France is a"romantic"nation though they may offer different answers to the question"Why".A recent source study shows that this image comes from the travel note written by a French priest Julie Aleni when he took a mission in China,from Wonders in the Voyage and Traveling around Europe and America by Zhang Deyi,a Chinese diplomat in France at that time and from Travel Notes by Wang Tao.Therefore,many Chinese modem writers borrowed this image to their works.Hence it has been created as a set image in the intertextual context of cultural homogeneity and heterogeneity.Therefore,this paper is intended to trace the signs of these cultural interactions so as to see how"Romantic France"has come to be a set image in Chinese culture.%什么词最能概括现代中国人心目中的法国形象?大多数人选择"浪漫"一词.但若再深问一句:法国何以是浪漫的?答案莫衷一是."浪漫法兰西"形象的起源始自法国神甫艾儒略的游记在中国的译介.张德彝和王韬追随艾儒略,现当代作家又追随张德彝和王韬,现代中国人心目中的"浪漫法兰西"形象就是在这种"同质"与"异质"的"互文"中构成的.

  10. The International Space Station and the Space Debris Environment: 10 Years On

    Science.gov (United States)

    Johnson, Nicholas; Klinkrad, Heiner

    2009-01-01

    tracked and cataloged have also been generated, but normally with even shorter orbital lifetimes. Finally, eight collision avoidance maneuvers have been performed to avoid potential collisions between ISS and large, tracked space debris. The most recent such maneuver was accomplished by ESA's Automated Transfer Vehicle, the Jules Verne, just three months before the 10th anniversary of the launch of ISS's first element.

  11. EarthScope Plate Boundary Observatory Data in the College Classroom (Invited)

    Science.gov (United States)

    Eriksson, S. C.; Olds, S. E.

    2009-12-01

    The Plate Boundary Observatory (PBO) is the geodetic component of the EarthScope project, designed to study the 3-D strain field across the active boundary zone between the Pacific and North American tectonics plates in the western United States. All PBO data are freely available to scientific and educational communities and have been incorporated into a variety of activities for college and university classrooms. UNAVCO Education and Outreach program staff have worked closely with faculty users, scientific researchers, and facility staff to create materials that are scientifically and technically accurate as well as useful to the classroom user. Availability of processed GPS data is not new to the geoscience community. However, PBO data staff have worked with education staff to deliver data that are readily accessible to educators. The UNAVCO Data for Educators webpage, incorporating an embedded Google Map with PBO GPS locations and providing current GPS time series plots and downloadable data, extends and updates the datasets available to our community. Google Earth allows the visualization GPS data with other types of datasets, e.g. LiDAR, while maintaining the self-contained and easy-to-use interface of UNAVCO’s Jules Verne Voyager map tools, which have multiple sets of geological and geophysical data. Curricular materials provide scaffolds for using EarthScope data in a variety of forms for different learning goals. Simple visualization of earthquake epicenters and locations of volcanoes can be used with velocity vectors to make simple deductions of plate boundary behaviors. Readily available time series plots provide opportunities for additional science skills, and there are web and paper-based support materials for downloading data, manipulating tables, and using plotting programs for processed GPS data. Scientists have provided contextual materials to explore the importance of these data in interpreting the structure and dynamics of the Earth. These data

  12. A 3-day regimen with azithromycin 1.5% eyedrops for the treatment of purulent bacterial conjunctivitis in children: efficacy on clinical signs and impact on the burden of illness

    Directory of Open Access Journals (Sweden)

    Bremond-Gignac D

    2015-04-01

    Full Text Available Dominique Bremond-Gignac,1,2 Riadh Messaoud,3 Sihem Lazreg,4 Claude Speeg-Schatz,5 Didier Renault,6 Frédéric Chiambaretta7,8 On behalf of the Azithromycin Pediatric Study Group 1Ophthalmology Department, Centre St Victor, University Hospital of Amiens, Picardie Jules Verne University, Amiens, France; 2CNRS FR3636, Paris V University, France; 3Ophthalmology Department, Tahar Sfar University Hospital, Mahdia, Tunisia; 4Dar El Beida, Blida, Algeria; 5Ophthalmology Department, University Hospital of Strasbourg, Strasbourg, France; 6Laboratoires THÉA, Clermont-Ferrand, France; 7Ophthalmology Department, University Hospital of Clermont-Ferrand, Gabriel Montpied Hospital, Clermont-Ferrand, France; 8EA 7281 R2D2, Auvergne University, Clermont-Ferrand, France Purpose: To compare the efficacy of azithromycin 1.5% versus tobramycin 0.3% eyedrops on clinical ocular signs and symptoms of bacterial conjunctivitis in children and to assess the parents’ satisfaction regarding the dosing regimen.Patients and methods: An international, multicenter, randomized, investigator-masked, controlled clinical trial conducted in children (1 day to 18 years old with bulbar conjunctival hyperemia and purulent discharge. Azithromycin 1.5% was administered as 1 drop twice daily for 3 days, and tobramycin 0.3% as 1 drop every 2 hours for 2 days, then 4 times daily for 5 days.Results: A total of 286 patients (mean age: 3.2 years were enrolled. In children with bacteriologically positive cultures (N=203, azithromycin produced a significantly greater improvement in conjunctival discharge (P<0.01 and a trend (P=0.054 toward improvement in conjunctival hyperemia at day 7 than did tobramycin. Complete resolution of conjunctival discharge was significantly more frequent at day 3 on azithromycin than tobramycin (P=0.005. More parents found azithromycin easier to use (in terms of treatment duration, total number of instillations, instilling drops during the day, and difficulty in

  13. Wisconsin builds a distributed resources collaborative: Looking for local solutions that work

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, C.

    1995-12-01

    I`d like to tell you how I got involved in the DR Collaborative and why I`m here. John Nesbitt asked me to come, to be the public advocate, the bumblebee on the EPRI body politic. What follows is my own thought, not that of John or my fellow collaborators, who may or may not agree with me. How did I come to know John Nesbitt? In August 1991, I found that some Wisconsin utilities intended to run a 138 kV transmission line across my property, along the driveway where my kids ride their bikes, along the high ground where we walk to escape the mosquitoes in the summer, where we ski cross-country and admire the snowy view in the winter. As a result, I became intensely interested in the electric power business. One thing led to another. I got on the Board of Wisconsin Demand-Side Demonstrations (WDSD), representing a group called the Citizens` Utility Board (CUB). I met Mr. Nesbitt. We shared an interest in distributed resources (DR). Along with some others, we conspired to initiate the Targeted Area Planning (TAP) collaborative. TAP is what we call DR in Wisconsin. I began to talk in acronyms. The simple truth is, I detest transmission lines. And, since transmission lines are invariably hooked up to central generation, I have no love for big power plants either. That whole system approach looks excessive and outdated to me, a vestige of the nineteenth century, Jules Verne without the romance. My opinion is, who needs it? I am aware that my opinion is not shared by everyone. I grant you that transmission lines might be a mite more acceptable if the thousands of landowners like me who presently subsidize their existence were receiving compensation, say an annual commodity transfer fee, that reflected some small portion of the value of transmission lines in the present system. That is certainly not the case, and if it were, the present system, when and if deregulated, would price itself out of existence all the more quickly.

  14. Voyager Interactive Web Interface to EarthScope

    Science.gov (United States)

    Eriksson, S. C.; Meertens, C. M.; Estey, L.; Weingroff, M.; Hamburger, M. W.; Holt, W. E.; Richard, G. A.

    2004-12-01

    tectonic processes are reflected in observed geophysical phenomena. Constructing maps by controlling map parameters and answering open-ended questions which describe, compare relationships, and work with both observed and model data, promote conceptual understanding of plate tectonics and related processes. The goals of curricular development emphasize inquiry, development of critical thinking skills, and student-centered interests. Custom editions of the map utility have been made as the "Jules Verne Voyager" and "Voyager Junior", for the International Lithosphere Project's "Global Strain Rate Map", and for EarthScope Education and Outreach as "EarthScope Voyager Jr.". For the latter, a number of EarthScope-specific features have been added, including locations of proposed USArray (seismic), Plate Boundary Observatory (geodetic), and San Andreas Fault Observatory at Depth sites, plus detailed maps and geographically referenced examples of EarthScope-related scientific investigations. As EarthScope develops, maps will be updated in `real time' so that students of all ages can use the data in formal and informal educational settings.

  15. Phytochemistry as a means for checking erroneously localized specimens

    NARCIS (Netherlands)

    Steenis, van C.G.G.J.

    1969-01-01

    In Flores, Timor, and some other of the Lesser Sunda Islands at least two distinct species of Eucalyptus occur, E. alba (vern. hoë) in the lowland and low hills and a second species (vern. anpupu) in the hills and mountains. A century ago Blume described some eucalypts from the Leyden Herbarium base

  16. French school and World War First: neurological consequences of a frightening time.

    Science.gov (United States)

    Gomes, Marleide da Mota

    2015-05-01

    Some aspects of a dark period in the history of the modern neurology, that of the World War I (WWI), are here remembered, mainly by the neurological French School participation . Some personalities and their works related to the WWI are presented such as Joseph Babinski, Jules Froment, Clovis Vincent, Jules Joseph Dejerine, Augusta Déjérine-Klumpke, Jules Tinel, Pierre Marie, Achille Alexandre Souques, Charles Foix, and Georges Guillain.

  17. French school and World War First: neurological consequences of a frightening time

    Directory of Open Access Journals (Sweden)

    Marleide da Mota Gomes

    2015-05-01

    Full Text Available Some aspects of a dark period in the history of the modern neurology, that of the World War I (WWI, are here remembered, mainly by the neurological French School participation . Some personalities and their works related to the WWI are presented such as Joseph Babinski, Jules Froment, Clovis Vincent, Jules Joseph Dejerine, Augusta Déjérine-Klumpke, Jules Tinel, Pierre Marie, Achille Alexandre Souques, Charles Foix, and Georges Guillain.

  18. Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

    Science.gov (United States)

    Ma, Qing; Gelbard, Harris A; Maggirwar, Sanjay B; Dewhurst, Stephen; Gendelman, Howard E; Peterson, Derick R; DiFrancesco, Robin; Hochreiter, Jill S; Morse, Gene D; Schifitto, Giovanni

    2013-06-01

    CEP-1347 is a potent inhibitor of mixed lineage kinase (MLK), which was investigated for ameliorating HIV-associated neurocognitive disorders. CEP-1347 and atazanavir pharmacokinetics were determined when CEP-1347 50 mg twice daily was administered to HIV-infected patients (n = 20) receiving combination antiretroviral therapy including atazanavir and ritonavir (ATV/RTV, 300/100 mg) once daily continuously. Co-administration of CEP-1347 and ATV/RTV resulted with significant changes in pharmacokinetics of ATV but not RTV. Specifically, an increase in ATV accumulation ratio of 15 % (p = 0.007) and a prolongation of T(½) from 12.7 to 15.9 h (p = 0.002) were observed. The results suggested that co-administration of CEP-1347 with ATV/RTV in HIV-infected patients might result in limited impact on ATV but not on RTV pharmacokinetics.

  19. All-terrain vehicle crashes and associated injuries in north Queensland: findings from the Rural and Remote Road Safety Study.

    Science.gov (United States)

    O'Connor, Teresa; Hanks, Heather; Steinhardt, Dale

    2009-10-01

    To define characteristics of all-terrain vehicle (ATV) crashes occurring in north Queensland from March 2004 till June 2007 with the exploration of associated risk factors. Descriptive analysis of ATV crash data collected by the Rural and Remote Road Safety Study. Rural and remote north Queensland. Forty-two ATV drivers and passengers aged 16 years or over hospitalised at Atherton, Cairns, Mount Isa or Townsville for at least 24 hours as a result of a vehicle crash. Demographics of participants, reason for travel, nature of crash, injuries sustained and risk factors associated with ATV crash. The majority of casualties were men aged 16-64. Forty-one per cent of accidents occurred while performing agricultural tasks. Furthermore, 39% of casualties had less than one year's experience riding ATVs. Over half the casualties were not wearing a helmet at the time of the crash. Common injuries were head and neck and upper limb injuries. Rollovers tended to occur while performing agricultural tasks and most commonly resulted in multiple injuries. Considerable trauma results from ATV crashes in rural and remote north Queensland. These crashes are not included in most general vehicle crash data sets, as they are usually limited to events occurring on public roads. Minimal legislation and regulation currently applies to ATV use in agricultural, recreational and commercial settings. Legislation on safer design of ATVs and mandatory courses for riders is an essential part of addressing the burden of ATV crashes on rural and remote communities.

  20. The simulated air flow pattern around a moving animal transport vehicle as the basis for a prospective biosecurity risk assessment

    Directory of Open Access Journals (Sweden)

    Jens Seedorf

    2017-08-01

    Full Text Available Research that investigates bioaerosol emissions from animal transport vehicles (ATVs and their importance in the spread of harmful airborne agents while the ATVs travel on roads is limited. To investigate the dynamical behaviour of theoretically released particles from a moving ATV, the open-source computational fluid dynamics (CFD software OpenFOAM was used to calculate the external and internal air flow fields with passive and forced ventilated openings of a common ATV moving at a speed of 80 km/h. In addition to a computed flow rate of approximately 40,000 m3/h crossing the interior of the ATV, the visualization of the trajectories has demonstrated distinct patterns of the spatial distribution of potentially released bioaerosols in the vicinity of the ATV. Although the front openings show the highest air flow to the outside, the recirculations of air masses between the interior of the ATV and the atmosphere also occur, which complicate the emission and the dispersion characterizations. To specify the future emission rates of ATVs, a database of bioaerosol concentrations within the ATV is necessary in conjunction with high-performance computing resources to simulate the potential dispersion of bioaerosols in the environment.

  1. Contribution à une étude des constructions antéposées du type : « En homme intelligent et humain, il partagea tout de suite l'inquiétude de Marcel » (J. Verne

    Directory of Open Access Journals (Sweden)

    Denis Vigier

    2008-07-01

    Full Text Available Dans cet article nous nous intéressons à une gamme de syntagmes prépositionnels (SP régis par la préposition « en » et dénotant une attitude, un comportement, un statut, une propriété plus ou moins permanente d’un actant. Nous étudions en particulier les emplois où ce SP apparaît détaché en tête de phrase, configuration peu étudiée jusqu’à présent à notre connaissance, notamment à partir de données attestées. Nous montrons que la portée sémantique de ces constituants ainsi que l’évaluation dont ils témoignent diffèrent sensiblement selon qu’ils apparaissent en position détachée frontale ou intraprédicative postverbale liée. Nous insistons enfin sur le caractère fréquemment polyphonique des énoncés qui les hébergentThis paper focuses on a set of Prepositional Phrases (PPs governed by the preposition “en” and indicating an attitude, a behaviour pattern, a status or a more or less permanent property of a participant. We study in particular sentences where the PP is placed in initial detached position, a construction to which little attention has been paid until now, especially when based on corpus data. We show that the semantic scope of these constituents and the judgement they express vary significantly according to their position (at the head of the sentence versus after the verb. We insist finally on the frequently polyphonic dimension of the sentences in which these constituents appear.

  2. Estudio de la adecuación al entorno natural de la vivienda vernácula en la Reserva de la Biosfera El Cielo Tamaulipas, México un análisis comparativo con la Reserva Sierra La Laguna, en Baja California Sur, México

    OpenAIRE

    Gali Leal, Eduardo

    2006-01-01

    En algunas ocasiones, por lo general en el transcurso de una conversación que sobre arquitectura se tenga, es usual escuchar algo sobre dos tópicos comunes, uno de ellos, referente a una frase de una familia que en México se expresó sobre la difícil experiencia de habitar en una vivienda que fuese premio nacional de arquitectura, y no precisamente por las múltiples entrevistas de que pudiese ser objeto, sino por lo incómodo de aquello que para los arquitectos es lo que se ve mejor, y de allí ...

  3. La lengua vernácula en los paratextos de los diccionarios y tratados sobre la lengua bajo el reinado de los Reyes Católicos: del romance contrapuesto al latín al castellano compañero del imperio

    OpenAIRE

    2014-01-01

    Este trabajo presenta la evolución del estatuto de la lengua castellana en los prólogos de las primeras ediciones de los diccionarios y artes dedicados a la lengua, publicados en Castilla a lo largo del reinado de los Reyes Católicos por cuatro autores: Antonio de Nebrija, principalmente, pero también Alfonso de Palencia, Rodrigo Fernández de Santaella, Fray Pedro de Alcalá. Fijándose en las sucesivas denominaciones de la lengua vulgar castellana y en el papel que le atribuyen los distintos p...

  4. The Jobs behind the Science

    CERN Multimedia

    Jacques Fichet; Jules Ordan; Anna Cook; Jacques Fichet

    2015-01-01

    Recruitments service promotes this clip "The Jobs behind the Science" Réalisé par Jules Ordan Produit par Jacques Fichet Voix off Anna Cook Musique : Unphased. Les musiciens: - Carlos Rosales - Tim McGarry - Ary Porat - Elio Jaillet - Jules Ordan - Didier Fellay

  5. Improving the Fit of a Land-Surface Model to Data Using its Adjoint

    Science.gov (United States)

    Raoult, Nina; Jupp, Tim; Cox, Peter; Luke, Catherine

    2016-04-01

    Land-surface models (LSMs) are crucial components of the Earth System Models (ESMs) which are used to make coupled climate-carbon cycle projections for the 21st century. The Joint UK Land Environment Simulator (JULES) is the land-surface model used in the climate and weather forecast models of the UK Met Office. In this study, JULES is automatically differentiated using commercial software from FastOpt, resulting in an analytical gradient, or adjoint, of the model. Using this adjoint, the adJULES parameter estimation system has been developed, to search for locally optimum parameter sets by calibrating against observations. We present an introduction to the adJULES system and demonstrate its ability to improve the model-data fit using eddy covariance measurements of gross primary production (GPP) and latent heat (LE) fluxes. adJULES also has the ability to calibrate over multiple sites simultaneously. This feature is used to define new optimised parameter values for the 5 Plant Functional Types (PFTS) in JULES. The optimised PFT-specific parameters improve the performance of JULES over 90% of the FLUXNET sites used in the study. These reductions in error are shown and compared to reductions found due to site-specific optimisations. Finally, we show that calculation of the 2nd derivative of JULES allows us to produce posterior probability density functions of the parameters and how knowledge of parameter values is constrained by observations.

  6. Long-term pharmacokinetic efficacy and safety of low-dose ritonavir as a booster and atazanavir pharmaceutical formulation based on solid dispersion system in rats.

    Science.gov (United States)

    Fukushima, Keizo; Haraya, Kenta; Terasaka, Shuichi; Ito, Yukako; Sugioka, Nobuyuki; Takada, Kanji

    2008-06-01

    Atazanavir (ATV) is clinically coadministered with low-dose ritonavir (RTV), which boosts the oral bioavailability (BA) of ATV by inhibiting cytochrome P450 (CYP) 3A, and P-glycoprotein (Pgp) via the same metabolic pathway; however, it is well known that in the chronic phase, the inhibition effect of RTV on Pgp and CYP3A becomes an induction effect. In this study, we investigated the long-term efficacy and safety of RTV-boosted ATV in rats with a clinical relevant dosage of ATV and RTV, 7 mg/kg and 2 mg/kg, respectively, and drew a direct comparison with RTV-boosted ATV and the previously reported ATV pharmaceutical formulation based on a solid dispersion system (ATV-SLS SD+G). Rats received RTV-boosted ATV or ATV-SLS SD+G for 14 d in the pharmacokinetic study. In addition, after 14-d repeated administration of each formulation, cyclosporine A (CyA) was administered to rats and Western blot analysis of Pgp and CYP3A was performed to investigate the impact on pharmacokinetic interaction of each ATV formulation. After repeated administration of both formulations, there was no significant difference between ATV pharmacokinetic parameters on day 1 and 14; therefore, it was considered that the long-term efficacy of both ATV formulations was maintained. However, after treatment with RTV-boosted ATV, the Cmax and AUC0-infinity of the following CyA significantly decreased to 49% and 47% in comparison to the control, respectively, and the Pgp expression in the small intestine by Western blot analysis was approximately 2-fold higher than the control, whereas after treatment with ATV pharmaceutical formulation, neither significant alteration of CyA nor notable change in the expression of intestinal Pgp and hepatic CYP3A was observed. Therefore, it was considered that the BA of CyA after treatment with RTV-boosted ATV would decrease by the induction effect of RTV in chronic phase as described above. The results of this study revealed that the chronic use of low-dose RTV as a

  7. 75 FR 54418 - Public Notice for a Change in Use of Aeronautical Property Associated With Wiscasset Municipal...

    Science.gov (United States)

    2010-09-07

    ... to George L. Worden it ux, dated May 29, 1968 and recorded in the Lincoln County Registry of Deeds... August 25, 2010. LaVerne F. Reid, Manager, Airports Division, New England Region. BILLING CODE 4910-13-M...

  8. learner perceptions in design critiques: impact on creative ...

    African Journals Online (AJOL)

    User

    Communication Design students at the Kwame Nkrumah University of Science and Technology. ... teacher in creating the appropriate learning ..... and create tension-filled environments, which ... Verne, CA: Architecture and Research. Press.

  9. Long-term effectiveness of unboosted atazanavir plus abacavir/lamivudine in subjects with virological suppression

    DEFF Research Database (Denmark)

    Llibre, Josep M; Cozzi-Lepri, Alessandro; Pedersen, Court

    2016-01-01

    Effectiveness data of an unboosted atazanavir (ATV) with abacavir/lamivudine (ABC/3TC) switch strategy in clinical routine are scant.We evaluated treatment outcomes of ATV + ABC/3TC in pretreated subjects in the EuroSIDA cohort when started with undetectable plasma HIV-1 viral load (pVL), perform...

  10. 77 FR 51731 - All-Terrain Vehicle Safety Summit

    Science.gov (United States)

    2012-08-27

    ... Innovations Topic Areas 1. State Legislation: Effecting Change Suggested topics: How to effect change; what works, what doesn't? Successes and failures with other outdoor products 2. ATV Training: Reaching the... discussion focusing on new innovations in ATV safety will allow stakeholders to work together to...

  11. Risk factors for roadway single- and multi-vehicle all-terrain vehicle crashes in Pennsylvania: 2010-2013.

    Science.gov (United States)

    Gorucu, Serap; Murphy, Dennis; Kassab, Cathy

    2017-01-01

    All Terrain Vehicles on public roadways become major risk factors for the motorists. To compare characteristics of crashes and injury severity related to single vehicle (SV) and multi-vehicle (MV) All-Terrain Vehicle (ATV) roadway crashes in Pennsylvania, USA. Data on ATV crashes occurring on public roads during the years 2010-2013 was obtained from the Pennsylvania Department of Transportation (PennDOT) and analyzed. Almost two-thirds of the incidents were single-vehicle incidents. Single-ATV incidents have a greater risk for incapacitating injury to drivers than do multi-vehicle ATV incidents. Other factors that increase risk for incapacitating injury in SV crashes include being male, being a driver, alcohol/drug involvement, hitting a fixed object, and the incidents in non-daylight hours. For MV ATV incidents, head on and rear-end crashes and drivers who had alcohol/drug involvement were the two major incapacitating injury risk factors. This study has enabled us to better understand roadway ATV incidents, characteristics of SV and MV ATV crashes, and the incapacitating injury risks in both SV and MV crash incidents. Our study suggests that road safety and public health programs should focus on the users' knowledge on laws regarding ATV usage on public roadways.

  12. Spectrophotometric method for simultaneous estimation of atazanavir sulfate and ritonavir in tablet dosage form

    Directory of Open Access Journals (Sweden)

    Disha A Patel

    2015-01-01

    Full Text Available Background: Ritonavir (RTV and atazanavir sulfate (ATV are protease inhibitor and RTV mostly used as a booster for increasing the bioavailability of other protease inhibitors like ATV. Aims: Quality assessment of the new dosage form of RTV and ATV i.e., tablets is very essential and hence this work deals with to develop sensitive, simple and precise method for simultaneous estimation of ATV and RTV in tablet dosage form by absorbance correction method. Materials and Methods: The present work was carried out on Shimadzu Ultraviolate(UV-1700 double beam spectrophotometer with 1 cm path length supported by S Shimadzu, model-1700(Japan, UV-Probe software, version 2.31 was used for spectral measurements with 10 mm matched quartz cells. Standard ATV and RTV were supplied by Cipla Pharmaceutical Ltd. Methanol was purchased from Finar Chemicals Pvt. Ltd. Results and Conclusion: The λmax or the absorption maxima for ATV and RTV were found to be 279 and 240 nm, respectively in methanol as solvent. The drugs follow Beer-Lambert′s law in the concentration range 30-90 and 10-30 μg/mL for ATV and RTV, respectively. The percentage recovery was found to be 100-100.33% and 100-101.5% for ATV and RTV, respectively. The method was validated for different parameters as per the International Conference for Harmonization Guidelines.

  13. The Realities of War: Assessing the Operational Risk of Revoking the Combat Exclusion Policy

    Science.gov (United States)

    2013-05-23

    programs, see: Everett Harman, Peter Frykman, Christopher Palmer, Eric Lammi, Katy Reynolds, and Verne Backus, “Effects of a Specifically Designed...Mauch, Beverly Ann Bendekgey, Kathleen M. Joyce, Julio Luna, and David Moser, Report to the Secretary of Defense, Washington D.C., July 1993. 84...Christopher Palmer, Eric Lammi, Katy Reynolds, and Verne Backus. “Effects of a Specifically Designed Physical Conditioning Program on the Load Carriage and

  14. Cell Calcium and the Control of Membrane Transport. Annual Symposium of the Society of General Physiologists (40th) Held in Woods Hole, Massachusetts on September 3-7, 1986.

    Science.gov (United States)

    1986-01-01

    Atif embrane Tran sport Chapter 9 A Chemical Link in Excitation-Contraction Coupling in Skel- etal Muscle Julio !ergara, Kamlesh Asotra, and Michael...much smaller lesions ("holes" of effective diameter 4 nm). but has the advantage of being quick and chemically clean and the "holes" can be vern ...the upper limit of the normal range of Ca> determined in intact cells. The verN steep dependence of the uniporter upon Ca> means that any increase in

  15. Factors Required for Successful Future Research in Decision Making

    Science.gov (United States)

    1999-06-01

    Verne Wheelwright. Uruvcrsit)’ of Houston, Clear-Lake 16 AC/UNU Mllk�.1Wll ProJect - Implementation of Futures Research in Decision Making...parts of the city separated by a 14 Submitted by Verne Wheelwright, Department of Studies of the Futw"e, University of Houston, Clear-Lake, Texas 1...Russian Fed. Abidjan, Ivory Coast Stanislaw Orzeszyna Julio A. Millan B. World Health Organization Jaya Kothai Pillai M. Salihu, Vice Chancellor

  16. Network Monitoring and Diagnosis Based on Available Bandwidth Measurement

    Science.gov (United States)

    2006-05-01

    encouragements helped me pass those tough early days in the US. I would also like to thank my officemates Julio Lopez and Rajesh Balan, both system experts. With...tradeoffs of structured overlays in a dynamic non-transitive network. In MIT 6.829 Fall 2003 class project, December 2003. [52] Ramesh Govindan and Vern ...using packet quartets. In ACM SIGCOMM Internet Measurement Workshop 2002, 2002. [92] Vern Paxson. Measurements and Analysis of End-to-End Internet

  17. Therapeutic drug monitoring (TDM of atazanavir in pregnancy

    Directory of Open Access Journals (Sweden)

    S Khoo

    2012-11-01

    Full Text Available Purpose of the study: Pregnant women experience physiological changes during pregnancy resulting in clinically significant alterations in antiretroviral pharmacokinetics (PK. Therefore, achieving and maintaining optimal plasma concentrations of antiretroviral drugs is essential for maternal health and minimising the risk of mother-to-child transmission of HIV. The aim of this study is to describe atazanavir/ritonavir (ATV/r PK during pregnancy. Methods: Pregnant HIV-positive women received ATV/r as part of their routine pre-natal care. Demographic and clinical data were collected, and ATV plasma concentrations [ATV] were determined in the first (T1, second (T2 and third (T3 trimester using HPLC-MS/MS (LLQ=0.05 µg/mL. Postpartum (PP sampling was performed where applicable. Antepartum (AP and PP PK parameters were compared using a one-way ANOVA. Summary of results: From January 2007, 44 women (37 black African were enrolled in the study. All received ATV/r at a standard dose of 1 tablet once daily (300/100 mg od. 24 women were receiving ART prior to pregnancy, and 20 women initiated ATV/r during pregnancy. Median (range gestation at treatment initiation in these patients was 23.5 weeks (7–35. At the time nearest to delivery 31 patients had an undetectable plasma viral load (pVL, 6 patients had detectable pVL and 2 were unavailable. [ATV] were determined in 11/44 (T1; 25/44 (T2; 35/44 (T3 and 28/44 (PP patients. Time of TDM sampling, gestation time and [ATV] (geometric mean; 95% CI are given in the Table. 6 patients were either below or approaching the ATV MEC (0.15 µg/mL during pregnancy; of these, 4/6 achieved undetectable pVL at the time of delivery (1=pVL of 291 copies/mL; 1 unavailable. [ATV] were significantly lower at T2/T3 relative to T1/PP. Equally, in a paired analysis of 28 patients (T2/T3 vs. PP, [ATV] were significantly reduced at T2/T3 (P=0.003. Conclusions: This study represents one of the larger cohorts of women undergoing TDM

  18. All-terrain vehicle-related nonfatal injuries among young riders in the United States, 2001-2010.

    Science.gov (United States)

    Shults, Ruth A; West, Bethany A; Rudd, Rose A; Helmkamp, James C

    2013-08-01

    To estimate the numbers and rates of all-terrain vehicle (ATV)-related nonfatal injuries among riders aged ≤ 15 years treated in hospital emergency departments (EDs) in the United States during 2001-2010. National Electronic Injury Surveillance System-All Injury Program data for 2001-2010 were analyzed. Numbers and rates of injuries were examined by age group, gender, primary body part injured, diagnosis, and hospital admission status. During 2001-2010, an estimated 361,161 ATV riders aged ≤ 15 years were treated in EDs for ATV-related injuries. The injury rate peaked at 67 per 100,000 children in 2004 and then declined to 42 per 100,000 children by 2010. The annualized injury rate for boys was double that of girls (73 vs 37 per 100,000). Children aged 11 to 15 years accounted for two-thirds of all ED visits and hospitalizations. Fractures accounted for 28% of ED visits and 45% of hospitalizations. The reasons for the decline in ATV-related injuries among young riders are not well understood but might be related to the economic recession of the mid-2000s and decreased sales of new ATVs. Although many states have regulations governing children's use of ATVs, their effectiveness in reducing injuries is unclear. Broader use of known effective safety measures, including prohibiting children aged ≤ 15 years from riding adult-sized ATVs, always wearing a helmet while riding, not riding on paved roads, and not riding as or carrying a passenger could additionally reduce ATV-related injuries among children. Last, more research to better understand ATV crash dynamics might lead to safer designs for ATVs.

  19. Discovering plate boundaries: Laboratory and classroom exercises using geodetic data to develop students' understanding of plate motion

    Science.gov (United States)

    Olds, S. E.

    2010-12-01

    available, the Jules Verne Voyager (JVV) interactive map tools are available online and are very well received by educators in introductory Earth science courses. In response to requests for easily accessible and usable data, UNAVCO built the Data for Educators webpage, incorporating an embedded Google Map with GPS locations and providing current GPS time series plots and downloadable data from the Plate Boundary Observatory. To extend and update the datasets available to our community, UNAVCO has developed a GPS velocity viewer using Google Maps technology and provides a learning- focused KMZ combining geophysical data sets for Google-Earth. By combining near real-time geodetic data with modern visualization tools into inquiry-based learning resources, students are deepening their understanding about the active nature of plate margins and gain a solid foundation for learning future concepts. UNAVCO is a non-profit, membership-governed consortium funded by the National Science Foundation and NASA.

  20. Snow drift: acoustic sensors for avalanche warning and research

    Science.gov (United States)

    Lehning, M.; Naaim, F.; Naaim, M.; Brabec, B.; Doorschot, J.; Durand, Y.; Guyomarc'h, G.; Michaux, J.-L.; Zimmerli, M.

    Based on wind tunnel measurements at the CSTB (Jules Verne) facility in Nantes and based on field observations at the SLF experimental site Versuchsfeld Weissfluhjoch, two acoustic wind drift sensors are evaluated against different mechanical snow traps and one optical snow particle counter. The focus of the work is the suitability of the acoustic sensors for applications such as avalanche warning and research. Although the acoustic sensors have not yet reached the accuracy required for typical research applications, they can, however, be useful for snow drift monitoring to help avalanche forecasters. The main problem of the acoustic sensors is a difficult calibration that has to take into account the variable snow properties. Further difficulties arise from snow fall and high wind speeds. However, the sensor is robust and can be operated remotely under harsh conditions. It is emphasized that due to the lack of an accurate reference method for snow drift measurements, all sensors play a role in improving and evaluating snow drift models. Finally, current operational snow drift models and snow drift sensors are compared with respect to their usefulness as an aid for avalanche warning. While drift sensors always make a point measurement, the models are able to give a more representative drift index that is valid for a larger area. Therefore, models have the potential to replace difficult observations such as snow drift in operational applications. Current models on snow drift are either only applicable in flat terrain, are still too complex for an operational application (Lehning et al., 2000b), or offer only limited information on snow drift, such as the SNOWPACK drift index (Lehning et al., 2000a). On the other hand, snow drift is also difficult to measure. While mechanical traps (Mellor 1960; Budd et al., 1966) are probably still the best reference, they require more or less continuous manual operation and are thus not suitable for remote locations or long

  1. UNAVCO Software and Services for Visualization and Exploration of Geoscience Data

    Science.gov (United States)

    Meertens, C.; Wier, S.

    2007-12-01

    UNAVCO has been involved in visualization of geoscience data to support education and research for several years. An early and ongoing service is the Jules Verne Voyager, a web browser applet built on the GMT that displays any area on Earth, with many data set choices, including maps, satellite images, topography, geoid heights, sea-floor ages, strain rates, political boundaries, rivers and lakes, earthquake and volcano locations, focal mechanisms, stress axes, and observed and modeled plate motion and deformation velocity vectors from geodetic measurements around the world. As part of the GEON project, UNAVCO has developed the GEON IDV, a research-level, 4D (earth location, depth and/or altitude, and time), Java application for interactive display and analysis of geoscience data. The GEON IDV is designed to meet the challenge of investigating complex, multi-variate, time-varying, three-dimensional geoscience data anywhere on earth. The GEON IDV supports simultaneous displays of data sets from differing sources, with complete control over colors, time animation, map projection, map area, point of view, and vertical scale. The GEON IDV displays gridded and point data, images, GIS shape files, and several other types of data. The GEON IDV has symbols and displays for GPS velocity vectors, seismic tomography, earthquake focal mechanisms, earthquake locations with magnitude or depth, seismic ray paths in 3D, seismic anisotropy, convection model visualization, earth strain axes and strain field imagery, and high-resolution 3D topographic relief maps. Multiple data sources and display types may appear in one view. As an example of GEON IDV utility, it can display hypocenters under a volcano, a surface geology map of the volcano draped over 3D topographic relief, town locations and political boundaries, and real-time 3D weather radar clouds of volcanic ash in the atmosphere, with time animation. The GEON IDV can drive a GeoWall or other 3D stereo system. IDV output

  2. Earthquakes in Action: Incorporating Multimedia, Internet Resources, Large-scale Seismic Data, and 3-D Visualizations into Innovative Activities and Research Projects for Today's High School Students

    Science.gov (United States)

    Smith-Konter, B.; Jacobs, A.; Lawrence, K.; Kilb, D.

    2006-12-01

    The most effective means of communicating science to today's "high-tech" students is through the use of visually attractive and animated lessons, hands-on activities, and interactive Internet-based exercises. To address these needs, we have developed Earthquakes in Action, a summer high school enrichment course offered through the California State Summer School for Mathematics and Science (COSMOS) Program at the University of California, San Diego. The summer course consists of classroom lectures, lab experiments, and a final research project designed to foster geophysical innovations, technological inquiries, and effective scientific communication (http://topex.ucsd.edu/cosmos/earthquakes). Course content includes lessons on plate tectonics, seismic wave behavior, seismometer construction, fault characteristics, California seismicity, global seismic hazards, earthquake stress triggering, tsunami generation, and geodetic measurements of the Earth's crust. Students are introduced to these topics through lectures-made-fun using a range of multimedia, including computer animations, videos, and interactive 3-D visualizations. These lessons are further enforced through both hands-on lab experiments and computer-based exercises. Lab experiments included building hand-held seismometers, simulating the frictional behavior of faults using bricks and sandpaper, simulating tsunami generation in a mini-wave pool, and using the Internet to collect global earthquake data on a daily basis and map earthquake locations using a large classroom map. Students also use Internet resources like Google Earth and UNAVCO/EarthScope's Jules Verne Voyager Jr. interactive mapping tool to study Earth Science on a global scale. All computer-based exercises and experiments developed for Earthquakes in Action have been distributed to teachers participating in the 2006 Earthquake Education Workshop, hosted by the Visualization Center at Scripps Institution of Oceanography (http

  3. Snow drift: acoustic sensors for avalanche warning and research

    Directory of Open Access Journals (Sweden)

    M. Lehning

    2002-01-01

    Full Text Available Based on wind tunnel measurements at the CSTB (Jules Verne facility in Nantes and based on field observations at the SLF experimental site Versuchsfeld Weissfluhjoch, two acoustic wind drift sensors are evaluated against different mechanical snow traps and one optical snow particle counter. The focus of the work is the suitability of the acoustic sensors for applications such as avalanche warning and research. Although the acoustic sensors have not yet reached the accuracy required for typical research applications, they can, however, be useful for snow drift monitoring to help avalanche forecasters. The main problem of the acoustic sensors is a difficult calibration that has to take into account the variable snow properties. Further difficulties arise from snow fall and high wind speeds. However, the sensor is robust and can be operated remotely under harsh conditions. It is emphasized that due to the lack of an accurate reference method for snow drift measurements, all sensors play a role in improving and evaluating snow drift models. Finally, current operational snow drift models and snow drift sensors are compared with respect to their usefulness as an aid for avalanche warning. While drift sensors always make a point measurement, the models are able to give a more representative drift index that is valid for a larger area. Therefore, models have the potential to replace difficult observations such as snow drift in operational applications. Current models on snow drift are either only applicable in flat terrain, are still too complex for an operational application (Lehning et al., 2000b, or offer only limited information on snow drift, such as the SNOWPACK drift index (Lehning et al., 2000a. On the other hand, snow drift is also difficult to measure. While mechanical traps (Mellor 1960; Budd et al., 1966 are probably still the best reference, they require more or less continuous manual operation and are thus not suitable for remote locations

  4. Plate Boundary Observatory Infrastructure and Data Products in Education and Outreach

    Science.gov (United States)

    Eriksson, S. C.; Barbour, K.; Lee, E.

    2005-12-01

    of young scientists and more established scientists broadening their research interests. In addition, collecting, manipulating, and aggregating real scientific data for classroom use is a current priority in science education. Educators want their students to use these data to draw conclusions following the logical processes characteristic of the scientific endeavor. Hence, PBO is a natural source of data for use in the classroom. Staff and community members are designing higher level data products for a variety of audiences in formal education (students and instructors in middle/high school, community colleges, undergraduate science majors and students in general science education, graduate students) and in informal education (museums, park information centers, science centers, and media. PBO is working on a chapter for the Earth Exploration Toolbox (http://serc.carleton.edu/eet/) for undergraduate general science education, and the Jules Verne Voyager will include a user-friendly interface and associated educational materials. Evaluation of the effectiveness of this entire program and of individual projects and products is a major undertaking. The multitude of tasks, integration of these tasks into a coherent program, and identification of resources for evaluation are both opportunities and challenges in helping build a program with measurable impact.

  5. Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis

    Directory of Open Access Journals (Sweden)

    C. I. Marinescu

    2015-01-01

    Full Text Available The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were evidenced in urine. Cumulative incidence of renal colic was 9.2 per 100 patients. The variables related to having renal colic were the presence of alkaline urine pH and lower basal creatinine clearance. The mean serum level of ATV was slightly higher in patients with renal colic—1,303 μg/L versus 1,161 μg/L—but did not reach statistical significance. Neither were any significant differences detected by analysing the levels according to the timetable for ATV dosage. Cumulative incidence of renal colic was high in patients being treated with ATV, in 33% of whom the presence of ATV crystals was evidenced in urine. We were unable to demonstrate a relationship between ATV serum levels and renal colic or progression towards renal failure.

  6. Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis.

    Science.gov (United States)

    Marinescu, C I; Leyes, M; Ribas, M A; Peñaranda, M; Murillas, J; Campins, A A; Martin-Pena, L; Barcelo, B; Barceló-Campomar, C; Grases, F; Frontera, G; Riera Jaume, Melchor

    2015-01-01

    The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were evidenced in urine. Cumulative incidence of renal colic was 9.2 per 100 patients. The variables related to having renal colic were the presence of alkaline urine pH and lower basal creatinine clearance. The mean serum level of ATV was slightly higher in patients with renal colic-1,303 μg/L versus 1,161 μg/L-but did not reach statistical significance. Neither were any significant differences detected by analysing the levels according to the timetable for ATV dosage. Cumulative incidence of renal colic was high in patients being treated with ATV, in 33% of whom the presence of ATV crystals was evidenced in urine. We were unable to demonstrate a relationship between ATV serum levels and renal colic or progression towards renal failure.

  7. Is ritonavir-boosted atazanavir a risk for cholelithiasis compared to other protease inhibitors?

    Science.gov (United States)

    Hamada, Yohei; Nishijima, Takeshi; Komatsu, Hirokazu; Teruya, Katsuji; Gatanaga, Hiroyuki; Kikuchi, Yoshimi; Oka, Shinichi

    2013-01-01

    To compare the incidence of complicated cholelithiasis in patients receiving ritonavir-boosted atazanavir (ATV/r)- containing antiretroviral therapy with those on other protease inhibitors (PIs). We conducted a single-center retrospective cohort study of patients who started either ritonavir-boosted ATV/r- or other PIs (ritonavir-boosted fosamprenavir, unboosted fosamprenavir, lopinavir/ritonavir, and ritonavir-boosted darunavir) -containing antiretroviral therapy. The incidence of complicated cholelithiasis was determined in each group. Complicated cholelithiasis was defined as follows: 1) cholelithiasis complicated by cholecystitis, cholangitis, or pancreatitis or 2) symptomatic cholelithiasis or choledocholithiasis which required invasive procedures such as cholecystomy and endoscopic retrograde cholangiopancreatography. The effects of ATV/r were estimated by univariate and multivariate Cox hazards models as the primary exposure. Complicated cholelithiasis was diagnosed in 3 patients (2.23 per 1000 person-years) in the ATV/r group (n = 466), and 3 (1.64 per 1000 person-years) in the other PIs group (n = 776), respectively. The incidence was not statistically different in the two groups by log-rank test (P = 0.702). By univariate and multivariate analysis adjusted for age and body weight, ATV/r use was not associated with cholelithiasis. (HR = 1.365; 95% CI, 0.275-6.775; p = 0.704) (adjusted HR = 1.390; 95% CI, 0.276-7.017; p = 0.690). For the 3 patients who developed cholelithiasis in the ATV/r group, the time to the diagnosis of cholelithiasis was 18, 34, and 39 months, respectively. In this study, the incidence of complicated cholelithiasis was low and was not different between patients on ATV/r and those on other PIs. On the contrary to ATV/r-associated nephrolithiasis, the possible risk of cholelithiasis should not preclude the use of ATV/r.

  8. Simplification to abacavir/lamivudine + atazanavir maintains viral suppression and improves bone and renal biomarkers in ASSURE, a randomized, open label, non-inferiority trial.

    Directory of Open Access Journals (Sweden)

    David A Wohl

    Full Text Available OBJECTIVE: Simplification of antiretroviral therapy in patients with suppressed viremia may minimize long-term adverse effects. The study's primary objective was to determine whether abacavir/lamivudine + atazanavir (ABC/3TC+ATV was virologically non-inferior to tenofovir/emtricitabine + atazanavir/ritonavir (TDF/FTC+ATV/r over 24 weeks in a population of virologically suppressed, HIV-1 infected patients. DESIGN: This open-label, multicenter, non-inferiority study enrolled antiretroviral experienced, HIV-infected adults currently receiving a regimen of TDF/FTC+ATV/r for ≥ 6 months with no history of virologic failure and whose HIV-1 RNA had been ≤ 75 copies/mL on 2 consecutive measurements including screening. Patients were randomized 1 ∶ 2 to continue current treatment or simplify to ABC/3TC+ATV. METHODS: The primary endpoint was the proportion of patients with HIV-RNA<50 copies/mL at Week 24 by the Time to Loss of Virologic Response (TLOVR algorithm. Secondary endpoints included alternative measures of efficacy, adverse events (AEs, and fasting lipids. Exploratory endpoints included inflammatory, coagulation, bone, and renal biomarkers. RESULTS: After 24 weeks, ABC/3TC+ATV (n = 199 was non-inferior to TDF/FTC+ATV/r (n = 97 by both the primary analysis (87% in both groups and all secondary efficacy analyses. Rates of grade 2-4 AEs were similar between the two groups (40% vs 37%, respectively, but an excess of hyperbilirubinemia made the rate of grade 3-4 laboratory abnormalities higher in the TDF/FTC+ATV/r group (30% compared with the ABC/3TC+ATV group (13%. Lipid levels were stable except for HDL cholesterol, which increased significantly in the ABC/3TC+ATV group. Bone and renal biomarkers improved significantly between baseline and Week 24 in patients taking ABC/3TC+ATV, and the difference between groups was significant at Week 24. No significant changes occurred in any inflammatory or coagulation biomarker within or between treatment

  9. Are standard wastewater treatment plant design methods suitable for any municipal wastewater?

    Science.gov (United States)

    Insel, G; Güder, B; Güneş, G; Ubay Cokgor, E

    2012-01-01

    The design and operational parameters of an activated sludge system were analyzed treating the municipal wastewaters in Istanbul. The design methods of ATV131, Metcalf & Eddy together with model simulations were compared with actual plant operational data. The activated sludge model parameters were determined using 3-month dynamic data for the biological nutrient removal plant. The ATV131 method yielded closer sludge production, total oxygen requirement and effluent nitrogen levels to the real plant after adopting correct influent chemical oxygen demand (COD) fractionation. The enhanced biological phosphorus removal (EBPR) could not easily be predicted with ATV131 method due to low volatile fatty acids (VFA) potential.

  10. Response by gender of HIV-1-infected subjects treated with abacavir/lamivudine plus atazanavir, with or without ritonavir, for 144 weeks

    Directory of Open Access Journals (Sweden)

    Squires KE

    2017-03-01

    Full Text Available Kathleen E Squires,1 Benjamin Young,2,3 Lizette Santiago,4 Robin H Dretler,5 Sharon L Walmsley,6 Henry H Zhao,7 Gary E Pakes,8 Lisa L Ross,8 Mark S Shaefer8 On behalf of the ARIES Study Team 1Thomas Jefferson University, Philadelphia, PA, 2Apex Family Medicine and Research, Denver, CO, 3International Association of Physicians in AIDS Care, Washington DC, USA; 4HOPE Clinic and Wellness Center, San Juan, Puerto Rico; 5ID Specialists of Atlanta, Decatur, GA, USA; 6University Health Network, Toronto, ON, Canada; 7GlaxoSmithKline, 8ViiV Healthcare, Research Triangle Park, NC, USA Purpose: The 144-week results of the open-label, multicenter Atazanavir/Ritonavir Induction with Epzicom Study (ARIES were stratified by gender to compare treatment responses.Methods: A total of 369 HIV-infected, antiretroviral-naïve subjects receiving once-daily abacavir/lamivudine + atazanavir/ritonavir (ATV/r whose HIV-1 RNA was <50 copies/mL by week 30 were randomized 1:1 at week 36 to maintain or discontinue ritonavir for 108 subsequent weeks. Between- and within-treatment gender-related efficacy and safety differences were analyzed.Results: Subjects were 85% male; 64% white; and had a mean age of 39 years, baseline median HIV-1 RNA of 114,815 copies/mL, and median CD4+ cell count of 198 cells/mm3. Gender (ATV [n=189]: 29 females/160 males; ATV/r [n=180]: 25 females/155 males and most other demographics were similar between groups; more females than males were black (65% vs 25% and fewer females had baseline HIV-1 RNA ≥100,000 copies/mL (41% vs 58%. At week 144, no significant differences between genders were observed in proportion maintaining HIV-1 RNA <50 copies/mL (ATV, 79% vs 77%; ATV/r, 60% vs 75% or <400 copies/mL (ATV, 83% vs 84%; ATV/r, 68% vs 82% (intent-to-treat-exposed: time to loss of virologic response analysis; median CD4+ change from baseline (ATV, +365 vs +300 cells/mm3; ATV/r, +344 vs +301 cells/mm3; proportion with treatment-related grade 2–4

  11. Punane Veski ja plakatikunsti algus / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2007-01-01

    Prantsuse plakatikunsti loojast Jules Cheret'st, ühest silmapaistvamast plakati- ja maalikunstnikust Henri Toulouse-Lautrecist, tema plakatite kangelannadest, kankaani tantsinud Louise Weberist ja Jane Avrilist ning Moulin Rouge'ist

  12. "Gypsy" ehk killuke Ameerikat meie jaoks / Martin Gorris

    Index Scriptorium Estoniae

    Gorris, Martin

    2001-01-01

    2. dets. esietendus Vanemuises Ameerika vodevillistaari ja striptiisikuninganna Rose Louise Hovicki memuaaridel põhinev Jule Styne'i muusikal "Gypsy", lavastaja Mare Tommingas, osades Silvi Vrait ja Helena Merzin

  13. Innate immunity's path to the Nobel Prize 2011 and beyond

    National Research Council Canada - National Science Library

    Wagner, Hermann

    2012-01-01

    The 2011 Nobel Prize in Physiology/Medicine to Ralph Steinmann, Jules Hoffmann, and Bruce Beutler recognized a paradigm shift in our understanding of innate immunity, and its impact on adaptive immunity...

  14. Evaluating the change of directional patterns for fingerprints with missing singular points under rotation

    CSIR Research Space (South Africa)

    Dorasamy, Kribashnee

    2016-12-01

    Full Text Available ) Advances in Visual Computing. ISVC 2016. Lecture Notes in Computer Science, vol 10073. Evaluating the Change of Directional Patterns for Fingerprints with Missing Singular Points Under Rotation Kribashnee Dorasamy Leandra Webb-Ray Jules...

  15. Massenet "Thaisi" näeb otseülekandes kinolinal / Toomas Kuter

    Index Scriptorium Estoniae

    Kuter, Toomas, 1965-

    2008-01-01

    Forum Cinemas toob oktoobrist maini Tallinnas Coca-Cola Plazas ja Tartus Ekraanis publikuni New Yorgi Metropolitan Opera etenduste HD-otseülekanded, 20. dets. kantakse üle Jules Massenet' ooper "Thais", peaosas Renee Fleming

  16. "Thais" muusika on fenomenaalne / Veronika Džiojeva ; intervjueerinud Silja Joon

    Index Scriptorium Estoniae

    Džiojeva, Veronika

    2009-01-01

    Küsimustele vastab 22. mail Pärnu Endla teatris esietenduva Jules Massenet' ooperi "Thais" nimiosatäitja, 2007. aastal toimunud Klaudia Taevi nim. rahvusvahelise ooperilauljate konkursi laureaat Veronika Džiojeva

  17. Cardioprotective effects of atorvastatin postconditioning on ischemia-reperfusion injury in isolated rat heart:the role of PI3K-Akt, mito-KATP channel and mPTP%PI3K-Akt、mito-KATP通道及mPTP在阿托伐他汀后处理减轻大鼠心肌缺血再灌注损伤中的作用

    Institute of Scientific and Technical Information of China (English)

    刘春伟; 丛洪良; 于雪芳; 韩薇

    2015-01-01

    Objective To observe the postconditioning cardioprotective effects of atorvastatin (ATV) on ischemia-re⁃perfusion injury in isolated rat heart, and the role of phosphatidylinositol-3-kinase , protein kinase B(PI3K-Akt), mitochon⁃drial ATP-sensitive potassium (mito-KATP channel) and mitochondrial permeability transition pore (mPTP) thereof. Meth⁃ods Healthy male Wistar rats were randomly divided into 9 groups:ischemia reperfusion (I/R) control group, atorvastatin postconditioning (ATV) group, ATV plus PI3K inhibitor LY294002 (ATV+LY294002) group, LY294002 group, ATV plus mi⁃to-KATP channel inhibitor 5-hydroxydecanoate (ATV+5-HD) group, 5-HD group, ATV plus mPTP inhibitor ATR (ATV+ATR) group, ATR group and ethanol group. Model rats were given 30-min ischemia followed by 120-min reperfusion. The myocardial infarction size, hemodynamic parameters, creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), nic⁃otinamide adenine dinucleotide (NAD+) and the expression of myocardial protein kinase B (Akt) and myocardial phospho-pro⁃tein kinase B (p-Akt) were evaluated. Results Compared with the control group, atorvastatin reduced the myocardial in⁃farction size, CK-MB and LDH(P<0.05), increased NAD+(P<0.05). There were no significant differences in the myocardi⁃al infarction size, CK-MB, LDH and NAD+between ATV+LY294002 group, ATV+5-HD group and ATV+ATR group. The hemodynamic parameters were improved in ATV group compared with those in control group. Western blot analysis con⁃ firmed the significant phosphorylation of Akt in ATV group, ATV+5-HD group and ATV+ATR group compared with those of control group. There were no significant differences in the phosphorylation of Akt between ATV +LY294002 group, LY294002 group, ATR group and 5-HD group. Conclusion Atorvastatin postconditioning could attenuate the ischemia-re⁃perfusion injury through activating the PI3K-Akt, promoting mito-KATP channel opening and inhibiting mPTP opening.%目的:观察阿托

  18. Tribute to a Leading Personality of World Horticultural Science

    OpenAIRE

    2010-01-01

    Following the proposal of Academic Council of Horticulture Faculty, the Senate of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca accepted nominee Professor Jules Janick for Doctor Honoris Causa award. The title was awarded in festive ceremony on September 30, 2010. Jules Janick, Professor at Purdue University has a long and distinguished career devoted to horticulture in all its facets. In horticultural research, he has made important advances including the gen...

  19. Lunar All-Terrain Utility Vehicle for EVA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations, LLC proposes to develop a new type of planetary rover called a Lunar All-terrain Utility Vehicle ("Lunar ATV") to assist extra-vehicular activities...

  20. Progress report on Bertelsen research and development of an air cushion crawler all-terrain vehicle

    Science.gov (United States)

    Bertelsen, W. R.

    1987-06-01

    The ACV is an exceptional amphibian but it is not, nor is any other existing craft, an all-terrain vehicle (ATV). Using the best elements of the ACV in an air-cushion crawler tractor, a true ATV can be attained. A conventional crawler drive train will propel two tracks as pressurized, propulsive pontoons. The key to a successful ATV is in perfecting efficient, durable, sliding seals to allow the belt to move in its orbit around the track unit and maintain its internal pressure. After deriving the adequate seal, a 12 inch wide x 86 inch long endless rubber belt was fitted bilateral seals and slide plates with internal guide wheels fore and aft with a 21 inch wheel base. From this approximately one-quarter scale model, full-scale air track crawlers, true ATVs, of any size and capacity can be produced.

  1. Management study. Off-road vehicle use on Panther Swamp National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This study discusses past and current ORV/ATV use on Panther Swamp National Wildlife Refuge and provides management objectives. Refuge staff concluded that the use...

  2. Head Injuries

    Science.gov (United States)

    ... ATV) Safety Balance Disorders Knowing Your Child's Medical History First Aid: Falls First Aid: Head Injuries Preventing Children's Sports Injuries Getting Help: Know the Numbers Concussions Stay Safe: Baseball Concussions Concussions: Getting Better Sports and Concussions Dealing ...

  3. Herding of reindeer in relation to birds and mammals on the northern Seward Peninsula

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Impacts of herding reindeer on foot, air, ATV. Also discusses impacts of egg gathering, bird hunting, and predator management completed by subsistent and reindeer...

  4. FF-Expert - an information system and computer program on inorganic coagulation/flocculation agents in waste water purification; FF-Expert - Ein Informationssystem und Rechenprogramm zum Einsatz anorganischer Faellungs-/Flockungschemikalien in der Abwasserreinigung

    Energy Technology Data Exchange (ETDEWEB)

    Langer, S. [Ingenieurgesellschaft Lahmeyer International, Bad Vilbel (Germany)

    1999-07-01

    The program permits analyses of the performance of inorganic coagulation/flocculation agents in communal sewage treatment. Calculation routines for the amount of chemical substances consumed, the sludge volume, the use of acid capacity etc. are implemented in the program. Its information part contains information from the ATV specification sheet 202, 'Processes for elimination of phosphorus from waste water'. The results of ATV WG 2.8.2 for different chemical products were integrated and utilized. [German] Das Programm erlaubt eine Analyse des Einsatzes von anorganischen Faellungs/Flockungschemikalien in der kommunalen Abwasserbehandlung. Berechnungsroutinen zum Chemikalienverbrauch, der Schlamm-Menge, dem Verbrauch an Saeurekapazitaet etc. wurden im Programm implementiert. Im Informationsteil enthaelt es wesentliche Inhalte aus dem ATV Arbeitsblatt 202 'Verfahren zur Elimination von Phosphor aus dem Abwasser'. Darueber hinaus wurden Erfahrungen von Mitgliedern der ATV-AG 2.8.2 mit diversen Chemikalienprodukten aufgearbeitet und im Programm verwendet. (orig.)

  5. 76 FR 24048 - Notice of Public Meeting, Coeur d'Alene District Resource Advisory Council Meeting; Idaho

    Science.gov (United States)

    2011-04-29

    ....m. The meeting will be held at the Super 8 Motel, 801 SW. 1st Street, Grangeville, Idaho 83530. FOR... regarding an alternative site for ATV use based on the Community Corrals, Bug Slope site closure....

  6. Nephrolithiasis and renal failure among patients exposed to atazanavir, other PIs and PI-free regimens

    Directory of Open Access Journals (Sweden)

    Ella Nkhoma

    2014-11-01

    Full Text Available Introduction: Recent single-site studies and case reports have linked atazanavir (ATV with the occurrence of nephrolithiasis. The purpose of this study was to estimate and compare the incidence rate of nephrolithiasis and to characterize the occurrence of subsequent renal failure among patients on ATV, other protease inhibitors (PIs and PI-free regimens using real world data. Materials and Methods: This was a retrospective cohort analysis using claims data from a US commercial and a US public health insurance database (Medicaid spanning 2003–2011 and 2006–2011, respectively. We identified adult HIV patients who were prescribed ATV, other PIs or PI-free regimens with at least 6 months of continuous enrolment prior to the index claim. Nephrolithiasis was defined as an inpatient or outpatient ICD-9 diagnosis code for nephrolithiasis or an associated condition, plus an imaging/corrective procedure code. Renal failure was also identified using diagnosis codes among patients experiencing nephrolithiasis. Hazard ratios were estimated using propensity score (PS adjusted Cox regression, crude and adjusted for demographics, baseline comorbidities and comedications. Results: A total of 14,477 patients (ATV: 4,150; other PIs: 4,153; PI-free: 6,174 were identified in the commercial database: 83% male and 20% age ≥50 years. In the Medicaid database, 9,104 patients (ATV: 3,460; other PIs: 3,117; PI-free: 2,527 were identified: 53% male and 25% age ≥50 years. There were significant baseline differences in demographics, comorbidities and concomitant medications among the three cohorts. In adjusted analyses, ATV use was not significantly associated with nephrolithiasis when compared to other PIs. When ATV was compared to PI-free regimens, a positive association was observed in the commercial insurance but not the Medicaid database. In both databases, previous history of nephrolithiasis was the strongest predictor of nephrolithiasis in the ATV

  7. High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

    Energy Technology Data Exchange (ETDEWEB)

    Podszun, Maren C.; Grebenstein, Nadine [Institute of Biological Chemistry and Nutrition, University of Hohenheim, D-70599 Stuttgart (Germany); Hofmann, Ute [Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, D-70376 Stuttgart (Germany); Frank, Jan, E-mail: jan.frank@nutrition-research.de [Institute of Biological Chemistry and Nutrition, University of Hohenheim, D-70599 Stuttgart (Germany); Department of Nutrition and Food Science, University of Bonn, D-53115 Bonn (Germany)

    2013-02-01

    It has been hypothesized in the literature that intake of high-dosage vitamin E supplements might alter the expression of cytochrome P{sub 450} enzymes (CYP), particularly CYP3A4, which may lead to adverse nutrient–drug interactions. Because previously published studies reported conflicting findings, we investigated the pharmacodynamics of the lipid-lowering drug atorvastatin (ATV), a CYP3A4 substrate, in response to high-dose α-tocopherol (αT) feeding and determined protein expression and activities of relevant CYP. Groups of ten female Dunkin–Hartley guinea pigs were fed a control (5% fat) or a high-fat control diet (HFC; 21% fat, 0.15% cholesterol) or the HFC diet fortified with αT (250 mg/kg diet), ATV (300 mg/kg diet) or both ATV + αT for 6 weeks. Relative to control, HFC animals had increased serum cholesterol concentrations, which were significantly reduced by ATV. High-dose αT feeding in combination with ATV (ATV + αT), albeit not αT feeding alone (αT), significantly lowered serum cholesterol relative to HFC, but did not alter the cholesterol-lowering activity of the drug compared to the ATV treated guinea pigs. Protein expression of CYP3A4, CYP4F2, CYP20A1 and OATP C was similar in all groups. Accordingly, no differences in plasma concentrations of phase I metabolites of ATV were observed between the ATV and ATV + αT groups. In conclusion, feeding guinea pigs high-doses of αT for 6 weeks did neither alter the hepatic expression of CYP, nor the pharmacodynamics and metabolism of ATV. High-dose αT intake is thus unlikely to change the efficacy of drugs metabolized by CYP enzymes, particularly by CYP3A4. -- Highlights: ► Vitamin E-atorvastatin interactions were studied in hypercholesterolemic guinea pigs. ► High-dose α-tocopherol did not alter the lipid-lowering efficacy of atorvastatin. ► α-Tocopherol did not change the expression of CYP3A4, CYP4F2, CYP20A or OATP C. ► α-Tocopherol did not affect phase I metabolism of atorvastatin

  8. Attenuation of Low Ambient Temperature-Induced Myocardial Hypertrophy by Atorvastatin via Promoting Bcl-2 Expression

    Directory of Open Access Journals (Sweden)

    Jing Liang

    2017-01-01

    Full Text Available Background/Aims: It is well documented that myocardial hypertrophy is associated with low ambient temperature. Atorvastatin (Atv has been shown to protect against atherosclerosis, cardiac fibrosis, ischemia/reperfusion injury, etc. In this study, we aim to determine whether atorvastatin is effective in the treatment of myocardial hypertrophy induced by cold exposure and to shed light on underlying mechanism. Methods: The mice aged 4-week were randomized to Control (Ctl group (raised at room temperature, Cold group (raised at 3-5ºC and Atv treatment group (raised at 3-5ºC followed by 10mg/kg/day Atv infusion. Echocardiography (ECG, HE, TUNEL and Masson’s trichrome staining, and Transmission electronic microscopy were performed to analyze cardiac function, myocardial hypertrophy, cardiac fibrosis, apoptosis and cardiomyocyte ultrastructure, respectively. Western blot was carried out to determine the involvement of MAPK and apoptosis pathways. Results: Exposure of mice to low temperature induced myocardial hypertrophic growth characterized by the elevation of heart/body weight index and heart weight /tibia length index, compared with control mice. Atv treatment attenuated cardiac hypertrophy induced by cold exposure; Atv also attenuated the increase of cross-sectional area of cardiomyocytes and cardiac collagen content fraction in mice exposed to cold. ECG showed that the decline of cardiac functions including the elevated left ventricular systolic/diastolic internal dimension (LVIDs/d and fractional shortening (FS in mice with cold exposure was also inhibited by Atv treatment. Transmission electronic microscopy uncovered that Atv attenuated mitochondrial injury induced by cold exposure in mice. In addition, systolic blood pressure was gradually increased in mice exposed to cold temperature, and Atv treatment significantly inhibited the elevation of blood pressure in cold-treated mice. Mechanistically, mitogen-activated protein kinase (MAPK

  9. Age-related patterns of spine injury in children involved in all-terrain vehicle accidents.

    Science.gov (United States)

    Sawyer, Jeffrey R; Beebe, Michael; Creek, Aaron T; Yantis, Matthew; Kelly, Derek M; Warner, William C

    2012-01-01

    With increases in use and power of all-terrain vehicles (ATVs), there have been dramatic increases in both the number and severity of ATV-related injuries. The KIDS database showed a 240% increase in the number of children admitted to a hospital for an ATV-related injury between 1997 and 2006. Over the same time period, there was a 476% increase in the number of children with ATV-related spine injuries. To better understand the nature of these injuries, a series of pediatric ATV-related spine fractures at a regional pediatric trauma center were analyzed. Records and radiographs of children and adolescents who presented to a regional pediatric trauma center with a spine injury as a result of an ATV accident were reviewed. In addition to demographic data, information was collected regarding length of stay, Glasgow Coma Score, Pediatric Trauma Score, treatment type, associated injuries, and hospital charges. Patients were divided into 2 groups based on age and American Academy of Orthopaedic Surgeons guidelines for ATV use: younger children (age, 0 to 15 y) and older children (age, 16 to 18 y). Fifty-three spine injuries were identified in 29 children (mean, 1.8 injuries/child) with an average age of 15.7 years; 16 (55%) had associated nonspine injuries and 13 had multiple spine injuries, contiguous in 9 and noncontiguous in 4. Four patients, all in the younger age group, had neurological injuries. Children older than 16 years had significantly lower Pediatric Trauma Scores and were more likely to have a thoracic spine fracture than younger children, who were more likely to have a lumbar fracture. Fourteen patients required surgery for their injuries, 7 for spine injuries and 7 for nonspine injuries; the mean hospital charge was almost $75,000 per patient. ATV-related spine injuries in children and adolescents are high-energy injuries with a high rate of associated spine and nonspine injuries. ATV-related spine injuries are different from other ATV-related injuries in

  10. A school-based study of adolescent all-terrain vehicle exposure, safety behaviors, and crash experience.

    Science.gov (United States)

    Jennissen, Charles A; Harland, Karisa K; Wetjen, Kristel; Peck, Jeffrey; Hoogerwerf, Pam; Denning, Gerene M

    2014-07-01

    More youth are killed every year in the United States in all-terrain vehicle (ATV) crashes than on bicycles, and since 2001, one-fifth of all ATV fatalities have involved victims aged 15 years or younger. Effectively preventing pediatric ATV-related deaths and injuries requires knowledge about youth riding practices. Our objective was to examine ATV use, crash prevalence, and riding behaviors among adolescent students in a rural state. We administered a cross-sectional survey to 4,684 youths aged 11 to 16 years at 30 schools across Iowa from November 2010 to April 2013. Descriptive and comparative analyses were performed. Regardless of rurality, at least 75% of students reported having been on an ATV, with 38% of those riding daily or weekly. Among ATV riders, 57% had been in a crash. Most riders engaged in risky behaviors, including riding with passengers (92%), on public roads (81%), or without a helmet (64%). Almost 60% reported engaging in all 3 behaviors; only 2% engaged in none. Multivariable modeling revealed male youth, students riding daily/weekly, and those reporting both riding on public roads and with passengers were 1.61 (95% CI, 1.36-1.91), 3.73 (95% CI, 3.10-4.50), and 3.24 (95% CI, 2.09-5.04) times more likely to report a crash, respectively. Three-fourths of youths surveyed were exposed to ATVs. The majority of riders had engaged in unsafe behaviors and experienced a crash. Given this widespread use and the potentially considerable morbidity of pediatric ATV crashes, prevention efforts, including anticipatory guidance by primary care clinicians serving families at risk, should be a higher priority. © 2014 Annals of Family Medicine, Inc.

  11. Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis

    OpenAIRE

    Marinescu, C. I.; Leyes, M.; M. A. Ribas; Peñaranda, M.; Murillas, J.; Campins, A. A.; Martin-Pena, L.; Barcelo, B.; Barceló-Campomar, C.; Grases, F.; Frontera, G; Melchor Riera Jaume

    2015-01-01

    The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were ...

  12. DoD Traffic Safety Program.

    Science.gov (United States)

    1994-11-22

    regulates operating privileges shall establish procedures for applicable mandatory administrative or disciplinary action, to include the suspension ...exhaust sys- tem, wipers, horns, brake systems, steering systems, suspension , tires, and wheel assemblies as well as the following: 1. The inspection... scooters , or ATVs, such 2-1 license requirements, as a minimum, shall apply to operation of those vehicles on DoD installations. (An ATV is a

  13. Effective pre-treatment of dairy wastewaters

    OpenAIRE

    Drev, Darko; Panjan, Jože

    2012-01-01

    Milk processing effluents typically present a considerable burden to the environemnt. The level of burden can be determined with the use of ATV (Allgemeine Technische Vertragsbedingungen), VDI (Verein Deutscher Ingenieure) and BAT (Best Available Techniques) standards, or via operational monitoring. Water emissions from dairy plants are associated with high water pollution costs. In our survey of dairy processing plants, we found water emissions in excess of ATV and BAT standard predictions. ...

  14. Dyslipidemic drugs in metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Sheelu S Siddiqi

    2013-01-01

    Full Text Available Introduction: Metabolic syndrome predisposes to diabetes and atherosclerotic vascular disease. Statins reduce cardiovascular events, so all metabolic syndrome patients should be evaluated for dyslipidemia. Many patients fail to achieve lipid goals with statin monotherapy. Co-administration of ezetimibe (EZE and atorvastatin (ATV may enable more patients to achievelow-density lipoproteincholesterol (LDL-C goal while avoiding risks of high-dose statin monotherapy. Materials and Methods: The present study compares rosuvastatin (Rsv with a combination of (Atv and (Eze. Metabolic syndrome patients, 30-70 years with LDL-C ≥130 mg/dl and a 10-year CHD risk score of 10% were randomized to double-blind treatment with (Rsv 5 mg (n = 67 or (Atv 10 mg+(Eze 10 mg (n = 68 for 12 weeks. Results: LDL-C reduced significantly; (32.3% and 30.3%, P < 0.001 in (Atv+(Eze and (Rsv, respectively, but there was no significant difference between two arms. More patients achieved LDL-C goal of ≤100 mg/dl with (Atv+(Eze compared to (Rsv (65% vs. 58%, P < 0.05. Triglycerides (TG were reduced more with (Atv+(Eze compared to (Rsv (28.1% and 21.4%, P < 0.001. Greater increase in high-density lipoprotein cholesterol (HDL-C was observed with (Atv+(Eze. Both treatments were well tolerated. Conclusion: This study shows that the combination of (Atv+(Eze has more efficacy and comparable safety to that of (Rsv.

  15. Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events

    DEFF Research Database (Denmark)

    Monforte, Antonella d'Arminio; Reiss, Peter; Nielsen, Lene Ryom;

    2013-01-01

    To investigate whether there is any association between exposure to atazanavir (ATV), either when boosted or unboosted by ritonavir, and myocardial infarction (MI) or stroke within the D:A:D: Study.......To investigate whether there is any association between exposure to atazanavir (ATV), either when boosted or unboosted by ritonavir, and myocardial infarction (MI) or stroke within the D:A:D: Study....

  16. Pesticidrester i fødevarer 2013

    DEFF Research Database (Denmark)

    Jensen, Bodil Hamborg; Andersen, Jens Hinge; Petersen, Annette

    udenlandske prøver sammenlignet med 8,7% af de danske prøver. 161 af prøverne er økologiske fødevarer, og sprøjterester er fundet i fire (2,5%) af prøverne, som alle er udenlandske. Kun ved en af prøverne er det dog vurderet, at økologireglerne er overtrådt. Som i tidligere år er der hverken fundet pesticider...... og grøntsager. Det gælder blandet andet udsving i vejret og deraf følgende problemer med for eksempel svampe- eller insektangreb. Resultatet af analysen viser dog et stabilt billede af, at danskproduceret frugt og grøntsager generelt indeholder et lavere niveau af sprøjterester....

  17. A Validated Spectral Discriminating Derivative Spectrophotometric Method for Simultaneous Quantification of Atorvastatin calcium and Fenofibrate Combination in Tablets

    Directory of Open Access Journals (Sweden)

    Panikumar D Anumolu

    2014-01-01

    Full Text Available A simple and specific second-order-derivative spectorophotometric method has been developed and validated for simultaneous quantification of atorvastatin calcium (ATV and fenofibrate (FEN in tablet dosage forms. ATV was determined at a wavelength of 281 nm (zero-crossing wavelength point of FEN. Similarly, FEN was measured at 296 nm (zero-crossing wavelength point of ATV in phosphate buffer, pH 2.8 as solvent. The second derivative amplitude-concentration plots were rectilinear over the range of 2-12 µg/mL for ATV and 1-30 µg/mL for FEN. The % assay in commercial formulation was found to be in the range 98.8 – 102.5 for ATV and 99.6 – 100.25 for FEN by the proposed method. The method was validated as per ICH guidelines. The proposed method can be effectively applied for routine analysis of ATV and FEN in tablets

  18. In vitro dissolution study of atorvastatin binary solid dispersion

    Science.gov (United States)

    Jahan, Rahat; Islam, Md. Saiful; Tanwir, Ahmad; Chowdhury, Jakir Ahmed

    2013-01-01

    The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188). Physical mixing (PM) and solvent evaporation (SE) method were used to prepare ATV-SD where different drug-carrier ratios were used. Prepared formulations were characterized in their solid state by solubility study; differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy which demonstrated changes in the formulations supporting the improved solubility. Percent content of POL188 in the SD matrix was found to play the pivotal role in the improvement of dissolution property of ATV. In case of PM, highest enhancement in drug release was found for 1:3 ratio (P < 0.05, ANOVA Single factor) whereas in case of SE, 3:0.5 ratio of ATV-POL188 resulted the maximum enhancement in ATV release (P < 0.05, ANOVA Single factor). Analysis of dissolution data of optimized formula indicated the best fitting with Peppas-Korsmeyer model and the drug release kinetics was fickian diffusion. In conclusion, binary SD prepared by both PM and SE technique using POL188 could be considered as a simple, efficient method to prepare ATV solid dispersions with significant improvement in the dissolution rate. PMID:23662278

  19. In vitro dissolution study of atorvastatin binary solid dispersion

    Directory of Open Access Journals (Sweden)

    Rahat Jahan

    2013-01-01

    Full Text Available The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV, a slight water-soluble drug, by solid dispersion (SD technique using a hydrophilic carrier Poloxamer 188 (POL188. Physical mixing (PM and solvent evaporation (SE method were used to prepare ATV-SD where different drug-carrier ratios were used. Prepared formulations were characterized in their solid state by solubility study; differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy which demonstrated changes in the formulations supporting the improved solubility. Percent content of POL188 in the SD matrix was found to play the pivotal role in the improvement of dissolution property of ATV. In case of PM, highest enhancement in drug release was found for 1:3 ratio (P < 0.05, ANOVA Single factor whereas in case of SE, 3:0.5 ratio of ATV-POL188 resulted the maximum enhancement in ATV release (P < 0.05, ANOVA Single factor. Analysis of dissolution data of optimized formula indicated the best fitting with Peppas-Korsmeyer model and the drug release kinetics was fickian diffusion. In conclusion, binary SD prepared by both PM and SE technique using POL188 could be considered as a simple, efficient method to prepare ATV solid dispersions with significant improvement in the dissolution rate.

  20. ELF/VLF/LF Radio Propagation and Systems Aspects (La Propagation des Ondes Radio ELF/VLF/LF et les Aspects Systemes)

    Science.gov (United States)

    1993-05-01

    Umime 11uld sb’ngft R11111M fgM 7-1 INVESTIGATIONS OF EQUATORIAL IONOSPHERE NIGHTTIME MODE CONVERSION AT VLF* Verne Hildebrand IWG Corporation, 1940 Fifth...uniform, Symposium), supposing that has an length equal to Ŗa" and it is MIT, Cambridge oriented on the zz direction (fig.8). USA, Julio 1991 Let us...about 10 to 14 years. My from the floor, would someone like to start off? own experience as a systems engineer is that Verne Hildebrand the systems have

  1. Long-term efficacy and toxicity of abacavir/lamivudine/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study.

    Science.gov (United States)

    de Boissieu, Paul; Dramé, Moustapha; Raffi, François; Cabie, André; Poizot-Martin, Isabelle; Cotte, Laurent; Garraffo, Rodolphe; Delobel, Pierre; Huleux, Thomas; Rey, David; Bani-Sadr, Firouzé

    2016-09-01

    Data on the long-term efficacy and safety of abacavir/lamivudine (ABC/3TC) and nevirapine (NVP) are scarce. This combination has the advantage of simplifying treatment and improving long-term tolerance. The aim of this study was to compare the rate of any discontinuation of antiretroviral (ARV) regimen because of virologic failure (VF), and/or adverse drug reaction (ADR) among patients receiving stable ARV regimens for at least 6 months.ABC/3TC/NVP was compared to ABC/3TC with either ritonavir-boosted darunavir (DRV/r) or ritonavir-boosted atazanavir (ATV/r), unboosted ATV, or tenofovir/emtricitabine (TDF/FTC) with either one of the following: ATV/r, unboosted ATV, DRV/r, efavirenz (EFV), or NVP, in the French prospective multicenter Dat'AIDS cohort.The study enrolled 16,511 patients treated with following ARV regimens: ABC/3TC/NVP (n = 1089), TDF/FTC/NVP (n = 1542), ABC/3TC/DRV/r (n = 1065), ABC/3TC/ATV/r (n = 1847), ABC/3TC/ATV (n = 563), TDF/FTC/ATV/r (n = 3519), TDF/FTC/DRV/r (n = 2767), TDF/FTC/ATV (n = 419), and TDF/FTC/EFV (n = 3700). Mean follow-up was 36 ± 24 months. Patients treated with ABC/3TC/NVP received this regimen as a switch regimen in 97% of cases. By multivariable analysis, the risk of treatment discontinuation due to VF was similar between ABC/3TC/NVP and other ARV regimens, except for TDF/FTC/ATV and ABC/3TC/ATV, which were associated with a higher risk of treatment interruption due to VF (hazard ratio [HR] 1.99; 95% confidence interval [CI] 1.29-3.06 and HR 2.19; 95% CI 1.51-3.18, respectively). Treatment discontinuation due to ADR was lowest with the ABC/3TC/NVP regimen. Other ARV regimens were associated with a 1.80- to 3.19-fold increase in the risk of treatment discontinuation due to ADR (P < 0.0001 for all comparisons).ABC/3TC/NVP as a simplification regimen is a long-term effective regimen with lower discontinuation due to long-term toxicity compared with other standard ARV regimens.

  2. Ritonavir-boosted darunavir is rarely associated with nephrolithiasis compared with ritonavir-boosted atazanavir in HIV-infected patients.

    Directory of Open Access Journals (Sweden)

    Takeshi Nishijima

    Full Text Available BACKGROUND: Although ritonavir-boosted atazanavir (ATV/r is known to be associated with nephrolithiasis, little is known about the incidence of nephrolithiasis in patients treated with ritonavir-boosted Darunavir (DRV/r, the other preferred protease inhibitor. METHODS: In a single-center cohort, the incidence of nephrolithiasis was compared between HIV-infected patients who commenced DRV/r-containing antiretroviral therapy and those on ATV/r. The effects of ATV/r use over DRV/r were estimated by univariate and multivariate Cox hazards models. RESULTS: Renal stones were diagnosed in only one patient (0.86 per 1000 person-years of the DRV/r group (n=540 and 37 (20.2 per 1000 person-years of the ATV/r group (n=517. The median [interquartile (IQR] observation period in the DRV/r group was 27.1 months (IQR 18.1-38.4 months, and 40.6 months (IQR 17.5-42.7 for the ATV/r group. The total observation period was 1,163.6 person-years and 1,829.6 person-years for the DRV/r group and for the ATV/r group, respectively. In the 37 patients on ATV/r who developed nephrolithiasis, the median time from commencement of ATV/r to diagnosis was 28.1 months (IQR 18.4-42.7, whereas nephrolithiasis in the single patient of the DRV/r group occurred 11.2 month after the introduction of DRV/r. ATV/r use over DRV/r was significantly associated with nephrolithiasis by uni- and multivariate analyses (HR=26.01; 95% CI, 3.541-191.0; p=0.001 (adjusted HR=21.47; 95% CI, 2.879-160.2; p=0.003. CONCLUSION: The incidence of nephrolithiasis was substantially lower in patients on DRV/r than those on ATV/r. The results suggest that DRV/r should be selected for treatment of HIV-infected patients at risk of chronic kidney disease.

  3. Boosted lopinavir vs boosted atazanavir in patients failing a NNRTI first line regimen in an urban clinic in Kampala

    Directory of Open Access Journals (Sweden)

    Eva Laker

    2014-11-01

    Full Text Available Introduction: In 2011 Uganda recommended boosted atazanavir (ATV/r as the preferred PI for second line due to once daily dosing, replacing aluvia (LPV/r (1, 2. The evidence was based on the BMS O45 trial, of LPV/r vs ATV/r was performed in a high-income setting, on patients with prior PI use and resistance testing (2, 3. There are no RCTs or observational studies comparing use of ATV/r with LPV/r in patients failing NNRTI first line antiretroviral therapy in sub-Saharan Africa (3, 4. The Infectious Diseases Institute (IDI has a large second line cohort (>1838. This aims to compare clinical, immunologic and virologic response of LPV/r versus ATV/r at IDI. Methods: Retrospective cohort analysis on routinely collected data of patients switched to second line with NRTI backbones TDF/3TC or FTC, AZT/3TC, ABC/3TC from January 2009 to December 2013. Students T-tests and Chi-square tests were used in this analysis. Results: A total of 1286 (73.5% female patients were switched to LPV/r 991 (77% and ATV/r 295 (23% (p<0.001. NRTI backbones were 760 on TDF/3TC (66.8% LPV/r vs 33.2% on ATV/r, 504 on AZT/3TC (93.3% vs 6.7%, and 22 on ABC/3TC (59% vs 41%. Median (IQR time on first line for LPV/r was 21 (1–44 months and for ATV/r was 41 months (22–68. Median CD4 (IQR at switch to LPV/r was 181 cells/uL (66–424 and to ATV/r was 122 (57–238 (p≤0.001. A total of 366 patients had CD4 done at six months after switch and the mean (IQR CD4 increase was 153 (54–241 for LPV/r versus 116 (52–171 for ATV/r (p=0.232. Additionally, 304 had a CD4 at 12 months and the means were 172 (45–272 for LPV/r vs 179 (60–271 for ATV/r (p=0.426. There was no significant difference in the mean increment by NRTI backbone or by stratifying to viral load (VL at time of switch to VL <100,000 and ≥100,000. Median (IQR VL at switch was 61,000 (13,000–2,030,000 LPV/r and 51,000 (14,000_151,000 ATV/r. 269 had a VL done in the first 12 months and 178/250 (71.2% on LPV

  4. Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir & GLUcose metabolism (ATAGLU) study.

    Science.gov (United States)

    d'Ettorre, Gabriella; Ceccarelli, Giancarlo; Zaccarelli, Mauro; Ascoli-Bartoli, Tommaso; Bianchi, Luigi; Bellelli, Valeria; De Girolamo, Gabriella; Serafino, Sara; Giustini, Noemi; Mastroianni, Claudio M; Vullo, Vincenzo

    2016-07-01

    Previous studies have reported that protease inhibitors (PIs) can contribute to glycaemic alterations. However, there are few trials examining the direct effect of a single PI. The objective of the study was to evaluate the modifications of glucose and lipid profiles after a switch from lopinavir/ritonavir (LPV/r) to atazanavir, used as ritonavir-boosted (ATV/r) or un-boosted. We conducted a retrospective observational cohort study on the effect of ATV/(r) on glycaemic metabolism (ATAGLU) in patients with undetectable levels of HIV-RNA who switched from LPV/r. In total, 235 patients treated for 48 weeks with LPV/r plus two nucleoside reverse transcriptase inhibitors (NRTIs) and with undetectable HIV-RNA were included: 134 continued LPV/r after the initial 48 weeks and 101 switched to ATV(/r) (18.3% to ATV; 24.7% to ATV/r). A significant decrease in mean glucose level and insulin resistance was observed in patients who switched to ATV(/r). The mean cholesterol triglyceride levels increased in the LPV/r group and decreased among the patients who switched. A significant increase of CD4 T cells with undetectable levels of HIV-RNA was observed in all groups. The long-term results obtained in this real-life study suggest that patients who have achieved initial suppression on a regimen including LPV/r + two NRTIs can switch to ATV/(r) + two NRTIs with an improvement in lipid and glycaemic metabolism.

  5. Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4.

    Science.gov (United States)

    Sanguino, Elena; Roglans, Nuria; Alegret, Marta; Sánchez, Rosa M; Vázquez-Carrera, Manuel; Laguna, Juan C

    2005-08-01

    Old rats are resistant to fibrate-induced hypolipidemia owing to a reduction in hepatic peroxisome proliferator-activated receptor alpha (PPARalpha). We tested whether the age-related decrease in PPARalpha is prevented by atorvastatin (ATV), a hypolipidemic statin. We determined the activity and expression of Liver X receptor alpha (LXRalpha) and PPARalpha in the liver of 18-month-old rats treated with 10 mg kg(-1) of ATV for 21 days. We measured fatty acid oxidation (FAO), the expression of PPARalpha-target genes, liver triglyceride (TG) and cholesteryl ester (CE) contents and plasma concentrations of TG, cholesterol, glucose, nonesterified fatty acids (NEFA), insulin and leptin. While old female rats were practically unresponsive, ATV-treated old males showed lower liver TG (-41%) and CE (-48%), and plasma TG (-35%), glucose (-18%) and NEFA (-39%). Age-related alterations in LXRalpha expression and binding activity were reverted in ATV-treated old males. These changes were related to an increase in hepatic FAO (1.2-fold), and PPARalpha mRNA (2.2-fold), PPARalpha protein (1.6-fold), and PPARalpha-binding activity. Hepatic nuclear factor-4 (HNF-4) and chicken ovalbumin upstream-transcription factor-II participate in the transcriptional regulation of the PPARalpha gene, while peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) behaves as a PPAR coactivator. Ageing reduced the hepatic content of HNF-4 (74%) and PGC-1 (77%) exclusively in male rats. ATV administration to old males enhanced the hepatic expression and binding activity (two-fold) of HNF-4. ATV-induced changes in hepatic HNF-4 and PPARalpha may be responsible for the improvement of the lipid metabolic phenotype produced by ATV administration to senescent male rats.

  6. Networking the Global Maritime Partnership

    Science.gov (United States)

    2011-06-01

    Victorians eagerly embraced the telegraph as something that was “faster and better” than waiting for newspapers to arrive via ship and something that would...resources in the expansive literature on the subject. Generally, in U.S. Navy parlance, it is spelled FORCEnet. This is because, then-CNO Admiral Vern

  7. De verborgen hand van culturele sturing

    NARCIS (Netherlands)

    Becker, H.M.

    2003-01-01

    Deze dissertatie bestaat uit een uitvoerige beschrijving van ‘good practice’, een casestudy dus. Humanitas Rotterdam als leverancier van zorg, welzijn en wonen is daarbij met een aantal theoretische instrumenten doorgelicht en ook uitvoerig empirisch onderzocht. Humanitas heeft een traditie van vern

  8. An Archaeological Survey of the Galisteo Dam and Reservoir Area Santa Fe County, New Mexico.

    Science.gov (United States)

    1982-01-01

    Geologic-climate dating in the West. American Antiquity 20: 317-355. Betancourt, Julio L. and Thomas R. Van Devender " 1981 Holocene vegetation in Cuaco...Prehistoric Southwestern turquoise industry. El Palacto 79(1): 33-51. Thoms, Alston Vern 1977 A preliminary projectile point typology for the southern

  9. USSR Report, Kommunist, No. 1, January 1987

    Science.gov (United States)

    1987-04-16

    the basis of collective ach^ vern ^ atrike oo venfclvely anticommunist bourgeois ^^^’^^l^robleL which, for some filling the theoretical vacuum...father, who had been born here. As one of the first communists in the country, he was personally familiar with Julio Antonio Mello and Buben

  10. Operations Events Census Report: Volume III, 1975-1980. Sanitized Version.

    Science.gov (United States)

    1985-04-01

    JULIO S. 2 0599 BARRETT, LARRY K. 2 0837 BARRETT, SUZANNE J. 2 0638 BARRETT, THOMAS J. 2 0602 BARRETT, WILLIAM H. 2 0680 BASH, SUSAN C. 2 0602 BASSETT...0636 HALPIN, PATRICK N. 2 0599 HAMBY, VERN 2 0679 HAMILTON, THOMAS K. 2 0837 HAMMIL, DANIEL E. 2 0923 HAMMOND, JOHN B. 2 0679 HAMMOND, RICHARD C. 2

  11. The Navy Unmanned Undersea Vehicle (UUV) Master Plan

    Science.gov (United States)

    2004-11-09

    Proceedings, October 2002, ADM Vern Clark, USN. Sea Shield: Projecting Global Defensive Assurance, Naval Instititute Proceedings, November 2002, VADM Mike...Goodman, Naval Undersea Warfare Center, Newport Julio Gutierrez, Naval Undersea Warfare Center, Newport LT Harper, Office of Naval Intelligence...Center, Panama City William Girodet, Locheed Martin Maritime Sensors & Systems Anthony Griffin, Office of Naval Intelligence Julio Gutierrez, Naval

  12. Military Review: The Professional Journal of the U.S. Army. January-February 2002

    Science.gov (United States)

    2002-02-01

    Situational Leadership Styles of Air Force Commanding Officer,” University of La Verne , Doctoral Dissertation, Dissertation Abstracts International, 53-07A...factors for success in more- studied amphibious battles of World War II were first used at Alhucemas Bay. MR NOTES 1. Julio Busquets, El Militar de

  13. Udbredelse af den baktielle zoonose i danske kvægbesætninger

    DEFF Research Database (Denmark)

    Bødker, Rene; Christoffersen, Anna-Bodil

    2008-01-01

    Tankmælksprøver fra 742 mælkeleverende kvægejendomme blev analyseret for antistoffer mod Coxiella burnetii i en ELISA. 57% af ejendommene havde positive prøver i den serologiske test. Prøverne var diagnostiske indsendelser til DTU Veterinærinstituttet og udgjorde derfor ikke en repræsentativ stik...

  14. De verborgen hand van culturele sturing

    NARCIS (Netherlands)

    Becker, H.M.

    2003-01-01

    Deze dissertatie bestaat uit een uitvoerige beschrijving van ‘good practice’, een casestudy dus. Humanitas Rotterdam als leverancier van zorg, welzijn en wonen is daarbij met een aantal theoretische instrumenten doorgelicht en ook uitvoerig empirisch onderzocht. Humanitas heeft een traditie van vern

  15. Blunt Trauma Data Correlation

    Science.gov (United States)

    1975-05-01

    Weapons (and other exciting protection, security and survival products). Product Brochure. 45. Roberts, Verne L. "Stun Gun" Preliminary Effects Study...1971. 57, Cruz-Jibaja, Julio C. Report Number4. Physiology of Respiration of High Elevations. DAHC 19-7I-GO001. University of Peru, Lima, Peru

  16. Linguagem médica voltada para o reumatologista: armadilhas e erros comuns

    Directory of Open Access Journals (Sweden)

    Carlos Frederico Arend

    2014-01-01

    Full Text Available O objetivo deste artigo é estimular o uso da lí ngua vernácula pelos profissionais da Área da saúde, comentando algumas palavras usualmente empregadas na comunicação entre médicos reumatologistas.

  17. Bruken av nasjonale prøver

    DEFF Research Database (Denmark)

    Skov, Poul

    2010-01-01

    Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

  18. 77 FR 49446 - Ocean Transportation Intermediary License Reissuances

    Science.gov (United States)

    2012-08-16

    ... Ocean Transportation Intermediary License Reissuances The Commission gives notice that the following Ocean Transportation Intermediary license has been reissued pursuant to section 40901 of the Shipping...: 1416 Blue Hill Avenue, Boston, MA 02125. Date Reissued: June 26, 2012. Vern W. Hill, Director,...

  19. Digital Forensics Research: The Next 10 Years

    Science.gov (United States)

    2010-01-01

    Kreibich Christian, Levchenko Kirill, Enright Brandon, Voelker Geoffrey M, Paxson Vern, Savage Stefan. Spamalytics: an empirical analysis of spam... Robert , Blundell Barry. The anatomy of electronic evidence â quantitative analysis of police e-crime data. In: International conference on

  20. Bruken av nasjonale prøver

    DEFF Research Database (Denmark)

    Skov, Poul

    2010-01-01

    Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

  1. Cost-utility analysis of lopinavir/ritonavir versus atazanavir + ritonavir administered as first-line therapy for the treatment of HIV infection in Italy: from randomised trial to real world.

    Directory of Open Access Journals (Sweden)

    Emanuela Foglia

    Full Text Available OBJECTIVE: To estimate the lifetime cost utility of two antiretroviral regimens (once-daily atazanavir plus ritonavir [ATV+r] versus twice-daily lopinavir/ritonavir [LPV/r] in Italian human immunodeficiency virus (HIV-infected patients naïve to treatment. DESIGN: With this observational retrospective study we collected the clinical data of a cohort of HIV-infected patients receiving first-line treatment with LPV/r or ATV+r. METHODOLOGY: A Markov microsimulation model including direct costs and health outcomes of first- and second-line highly active retroviral therapy was developed from a third-party (Italian National Healthcare Service payer's perspective. Health and monetary outcomes associated with the long-term use of ATV+r and LPV/r regimens were evaluated on the basis of eight health states, incidence of diarrhoea and hyperbilirubinemia, AIDS events, opportunistic infections, coronary heart disease events and, for the first time in an economic evaluation, chronic kidney disease (CKD events. In order to account for possible deviations between real-life data and randomised controlled trial results, a second control arm (ATV+r 2 was created with differential transition probabilities taken from the literature. RESULTS: The average survival was 24.061 years for patients receiving LPV/r, 24.081 and 24.084 for those receiving ATV+r 1 and 2 respectively. The mean quality-adjusted life-years (QALYs were higher for the patients receiving LPV/r than those receiving ATV+r (13.322 vs. 13.060 and 13.261 for ATV+r 1 and 2. The cost-utility values were 15,310.56 for LPV/r, 15,902.99 and 15,524.85 for ATV+r 1 and 2. CONCLUSIONS: Using real-life data, the model produced significantly different results compared with other studies. With the innovative addition of an evaluation of CKD events, the model showed a cost-utility value advantage for twice-daily LPV/r over once-daily ATV+r, thus providing evidence for its continued use in the treatment of HIV.

  2. Imaging findings in 512 children following all-terrain vehicle injuries

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Chetan C.; Greenberg, Bruce S. [Arkansas Children' s Hospital, Department of Pediatric Radiology, Little Rock, AR (United States); University of Arkansas for Medical Sciences, Department of Radiology, Little Rock, AR (United States); Ramakrishnaiah, Raghu H. [University of Arkansas for Medical Sciences, Department of Radiology, Little Rock, AR (United States); Bhutta, Sadaf T. [Arkansas Children' s Hospital, Department of Pediatric Radiology, Little Rock, AR (United States); Parnell-Beasley, Donna N. [Arkansas Children' s Hospital, Pediatric Surgery and Trauma, Little Rock, AR (United States)

    2009-07-15

    Injuries related to all-terrain vehicle (ATV) use by children have increased in recent years, and the pattern of these injuries is not well known among radiologists. Our purpose was to identify different radiologically diagnosed injuries in children suffering ATV-related trauma and determine associations among various injuries as well as between injuries and outcome. The study included 512 consecutive children suffering from ATV injuries treated at a tertiary care pediatric hospital. All imaging studies were reviewed and correlated with injury frequency and outcome using multivariate analysis. Head injuries occurred in 244 children (48%) and in five of six deaths. Calvarial skull fractures occurred in 104 children and were associated with brain, subdural and epidural injuries. Brain and orbit injuries were associated with long-term disability. A total of 227 extremity fractures were present in 172 children (34%). The femur was the most commonly fractured bone. Nine children had partial foot amputations. Multiorgan injuries occurred in nearly half of the 97 children with torso injuries. Determinants for long-term disability or death were head injuries (odds ratio 3.4) and extremity fractures (odds ratio 3.3). Head and extremity injuries are the two most common injuries in children suffering ATV injuries and are associated with long-term disability. ATV use by children is dangerous and is a significant threat to child safety. (orig.)

  3. Hysteria in fin de siècle French novels.

    Science.gov (United States)

    Walusinski, Olivier

    2013-01-01

    During the second half of the 19th century, sociopolitical conditions and society's interest in psychological questions transformed the millennial concept of hysteria into a sociocultural representation of the female condition and sexuality. Influenced by the public demonstrations of Jean-Martin Charcot at La Salpêtrière, many writers attempted to magnify this neurologist's work in their novels. In this chapter, we will analyze several representative passages written by Jules Clarétie, Camille Lemonnier, Jules Lermina, Octave Mirbeau, Joris-Karl Huysmans, and Gustave Flaubert, bearing in mind the scientific, progressive, and anticlerical ideas of the time.

  4. Alle ønsker sig en Lego-aktie til jul

    DEFF Research Database (Denmark)

    Iversen, Martin Jes

    2014-01-01

    Både små og store investorer får julelys i øjnene ved tanken om at eje et stykke af Lego. På sigt kunne en børsnotering gøre Danmark til et rigere land.......Både små og store investorer får julelys i øjnene ved tanken om at eje et stykke af Lego. På sigt kunne en børsnotering gøre Danmark til et rigere land....

  5. Identification of essential and non-essential genes in Ambystoma tigrinum virus.

    Science.gov (United States)

    Aron, Mariah M; Allen, Alexander G; Kromer, Mathew; Galvez, Hector; Vigil, Brianna; Jancovich, James K

    2016-06-01

    Members of the genus Ranavirus (family Iridoviridae) are large double-stranded (ds) DNA viruses that are found world-wide infecting fish, amphibian and reptile ectothermic hosts. Ranavirus genomes range from 105 to 155kbp in length and they are predicted to encode around 90-125 genes. Currently, our knowledge of the function of ∼50% of these genes is known or inferred based on homology to orthologous genes characterized in other systems; however, the function of the remaining open reading frames (ORFS) is unknown. Therefore, in order to begin to uncover the function of unknown ORFs in ranaviruses we developed a standardized approach to generate a recombination cassette for any ORF in Ambystoma tigrinum virus (ATV). Our standardized approach quickly and efficiently assembles recombination cassettes and recombinant ATV. We have used this approach to identify two essential, one semi-essential and two non-essential genes in ATV.

  6. Injuries from all-terrain vehicles: An opportunity for injury prevention.

    Science.gov (United States)

    Benham, Emily C; Ross, Samuel W; Mavilia, Mariana; Fischer, Peter E; Christmas, A Britton; Sing, Ronald F

    2017-08-01

    Patient demographics, behavior, and injury patterns were assessed to inform preventative efforts for reduced incidence of all-terrain vehicle (ATV) trauma. ATV-related injuries treated at a Level I trauma center from 2008 to 2012 were retrospectively reviewed. Patient outcomes and incidence of traumatic brain injury (TBI) were compared by helmet use and alcohol intoxication. Helmet data were available for 304 patients of 404 patients included; of these, 75 (24.7%) wore a helmet. Incidence of TBI was lower in the helmeted (8.0%) versus the unhelmeted subgroup (26.6%) (P injury severity scores, lower intensive-care unit (ICU) admission rates, and shorter ICU and hospital length of stay (LOS) (P injury prevention among ATV users. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Design And Development Of Roll Cage For An All-Terrain Vehicle

    Directory of Open Access Journals (Sweden)

    Khelan Chaudhari

    2013-12-01

    Full Text Available The study aims to design, develop and fabricate a roll cage for an All-Terrain Vehicle (ATV in accordance with the rulebook of BAJA 2013 given by SAE. A roll cage is a skeleton of an ATV. The roll cage not only forms the structural base but also a 3-D shell surrounding the occupant which protects the occupant in case of impact and roll over incidents. The roll cage also adds to the aesthetics of a vehicle. The design and development comprises of material selection, chassis and frame design, cross section determination, determining strength requirements of roll cage, stress analysis and simulations to test the ATV against failure. Finally the roll cage is fabricated as per the tools and techniques available in the workshop.

  8. Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks.

    Science.gov (United States)

    Aberg, Judith A; Tebas, Pablo; Overton, Edgar Turner; Gupta, Samir K; Sax, Paul E; Landay, Alan; Falcon, Ron; Ryan, Robert; De La Rosa, Guy

    2012-10-01

    We assessed metabolic changes for darunavir/ritonavir (DRV/r) once daily (qd) versus atazanavir/ritonavir (ATV/r) qd with fixed-dose tenofovir/emtricitabine. This was a phase 4, multicenter, open-label, randomized exploratory study. Treatment-naive, HIV-1-infected adults received DRV/r 800/100 mg qd or ATV/r 300/100 mg qd, both with emtricitabine/tenofovir 200/300 mg qd. Primary end point: change in triglyceride levels from baseline to week 12. Secondary end points: week 12 and week 48 changes in lipid parameters, insulin sensitivity, inflammatory/coagulation/bacterial translocation biomarkers, viral load, CD4(+) cell count, and week 48 changes in adipose tissue distribution and subjects' perceptions of body changes. In the DRV/r arm, 32/34 and 29/34 subjects completed weeks 12 and 48, respectively; in the ATV/r arm, 30/31 and 25/31 subjects completed weeks 12 and 48, respectively. Small changes in lipid parameters from baseline to weeks 12 and 48 were observed in both arms. Differences were noted between arms in mean changes in total cholesterol (DRV/r, 20.3 mg/dl; ATV/r, 4.6 mg/dl) and apolipoprotein A1 (DRV/r, 10.7 mg/dl; ATV/r, -0.7 mg/dl) at week 12. At week 48, no clinically relevant differences between arms were noted for changes in any lipid parameter, fasting glucose, or insulin sensitivity. Biomarkers generally decreased and efficacy parameters improved in both arms over 48 weeks. Changes in adipose tissue were small and comparable between arms. Subjects' perceptions of body changes generally improved in both study arms. This first pilot comparison in HIV-1-infected subjects suggests that DRV/r has a metabolic profile similar to ATV/r over 48 weeks of treatment. Further randomized studies are warranted.

  9. Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir

    LENUS (Irish Health Repository)

    Cotter, Aoife G

    2013-05-16

    AbstractObjectiveTo determine the factors associated with change in bilirubin concentration 12 weeks after the initiation of an atazanavir (ATV)-containing antiretroviral regimen.MethodsWe performed a retrospective case note review of all patients prescribed ATV between January 2004 and October 2007 in a cohort of HIV infected subjects. Data collected included baseline demographics, hepatitis B and C serology, current antiretroviral therapy, baseline and week 12 routine bloods. The primary endpoint was the change in bilirubin concentration at 12 weeks after start of ATV. Multvariable linear regression was performed to assess the relationships between the change in bilirubin and variables of interest. Results: Eighty-three ATV-treated patients were included in the analysis of whom 46 (60.5%) were hepatitis C antibody positive. The median (interquartile range) change in bilirubin by week 12 was 16 (4, 22) umol\\/L; only 1 patient developed grade 4 hyperbilirubinaemia at week 12. After controlling for baseline bilirubin levels, HCV seropositivity and baseline ALP were associated with a smaller change in bilirubin over the 12 weeks with a trend towards lower increases in those receiving tenofovir. Sensitivity analyses reported similar associations with methadone use and injection drug use, when these variables replaced HCV sero-positivity in the model. Conclusion: Patients with hepatitis C co-infection experience smaller changes in bilirubin upon exposure to ATV. Although the underlying mechanism for this association remains unclear, these data support the safe use of this drug in this patient setting. Further research into the clinical predictors of ATV-related hyperbilirubinaemia is warranted.

  10. Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

    Science.gov (United States)

    Macwan, Joyce S; Ionita, Ileana A; Dostalek, Miroslav; Akhlaghi, Fatemeh

    2011-04-01

    The aim of the proposed work was to develop and validate a simple and sensitive assay for the analysis of atorvastatin (ATV) acid, ortho- and para-hydroxy-ATV, ATV lactone, and ortho- and para-hydroxy-ATV lactone in human plasma using liquid chromatography-tandem mass spectrometry. All six analytes and corresponding deuterium (d5)-labeled internal standards were extracted from 50 μL of human plasma by protein precipitation. The chromatographic separation of analytes was achieved using a Zorbax-SB Phenyl column (2.1 mm × 100 mm, 3.5 μm). The mobile phase consisted of a gradient mixture of 0.1% v/v glacial acetic acid in 10% v/v methanol in water (solvent A) and 40% v/v methanol in acetonitrile (solvent B). All analytes including ortho- and para-hydroxy metabolites were baseline-separated within 7.0 min using a flow rate of 0.35 mL/min. Mass spectrometry detection was carried out in positive electrospray ionization mode, with multiple-reaction monitoring scan. The calibration curves for all analytes were linear (R(2) ≥ 0.9975, n = 3) over the concentration range of 0.05-100 ng/mL and with lower limit of quantitation of 0.05 ng/mL. Mean extraction recoveries ranged between 88.6-111%. Intra- and inter-run mean percent accuracy were between 85-115% and percent imprecision was ≤ 15%. Stability studies revealed that ATV acid and lactone forms were stable in plasma during bench top (6 h on ice-water slurry), at the end of three successive freeze and thaw cycles and at -80 °C for 3 months. The method was successfully applied in a clinical study to determine concentrations of ATV and its metabolites over 12 h post-dose in patients receiving atorvastatin.

  11. Atazanavir-loaded Eudragit RL 100 nanoparticles to improve oral bioavailability: optimization and in vitro/in vivo appraisal.

    Science.gov (United States)

    Singh, Gurinder; Pai, Roopa S

    2016-01-01

    Atazanavir (ATV) is a HIV protease inhibitor. Due to its intense lipophilicity, the oral delivery of ATV encounters several problems such as poor aqueous solubility, pH-dependent dissolution, rapid first-pass metabolism in liver by CYP3A5, which result in low bioavailability. To overcome afore mentioned limitations, ATV-loaded Eudragit RL100 nanoparticles (ATV NPs) were prepared to enhance oral bioavailability. ATV NPs were prepared by nanoprecipitation method. The ATV NPs were systematically optimized (OPT) using 3(2) central composite design (CCD) and the OPT formulation located using overlay plot. The pharmacokinetic study of OPT formulation was investigated in male Wistar rats, and in-vitro/in-vivo correlation level was established. Intestinal permeability of OPT formulation was determined using in situ single pass perfusion (SPIP) technique. Transmission electron microscopy studies on OPT formulation demonstrated uniform shape and size of particles. Augmentation in the values of Ka (2.35-fold) and AUC0-24 (2.91-fold) indicated significant enhancement in the rate and extent of bioavailability by the OPT formulation compared to pure drug. Successful establishment of in vitro/in vivo correlation (IVIVC) Level A substantiated the judicious choice of the in vitro dissolution milieu for simulating the in vivo conditions. In situ SPIP studies ascribed the significant enhancement in absorptivity and permeability parameters of OPT formulation transport through the Peyer's patches. The studies, therefore, indicate the successful formulation development of NPs with distinctly improved bioavailability potential and can be used as drug carrier for sustained or prolonged drug release.

  12. Efecto de las concentraciones de ritonavir en la farmacocinética de atazanavir: aplicación de técnicas de modelado y simulación farmacocinético poblacional

    OpenAIRE

    Estévez Gómez, Javier Alejandro

    2016-01-01

    Introducción: La infección por VIH se ha convertido en una enfermedad crónica debido principalmente a la introducción de la terapia antirretroviral. Atazanavir(ATV) se administra potenciado con ritonavir (RTV), siendo la dosis habitual 300mg de ATV y 100mg de RTV una vez al día, aunque también se puede administrar sin potenciar. Actualmente la simplificación de los tratamientos antirretrovirales es uno de los objetivos más importantes para facilitar el cumplimiento de la terapia y evitar e...

  13. 变频器在合成驰放气压缩机改造中的应用%Selection Inverter for Technological Transformation of Synthetic Relief Gas Compressors

    Institute of Scientific and Technical Information of China (English)

    王培磊

    2007-01-01

    介绍了在合成驰放气压缩机改造系统中所采用的变频器的设计选型原则.对ATV68变频器的性能特点、使用后的效果、投用注意事项以及故障分析做了介绍.ATV68投入使用后达到了节能调速的目的,并在排除故障后一直稳定运行.

  14. Rastreio VIH e sexo (in)seguro. Uma intervenção no Campus Universitário de Évora

    OpenAIRE

    Frias, Ana; Palminhas, Edgar; Chora, Antonia; Caldeira, Ermelinda; Sim-Sim, Margarida; Casas Novas, Vitória

    2014-01-01

    Introdução: O Rastreio para VIH, na forma de Aconselhamento e Teste Voluntário (ATV), protege o individuo e potenciais parceiros, diminui comportamentos de risco, é reconhecido nas estratégias de prevenção (Fonner, Denison, Kennedy, O'Reilly, & Sweat, 2012). O ATV-VIH acontece em universidades estrangeiras (Hoban, Ottenritter, Gascoigne, & Kerr, 2003; Matlala, Mokono, & Tsotetsi, 2013; Peltzer, Nzewi, & Mohan, 2004), mas tal não é frequente em Portugal. Objetivo: descrever os resultados do ra...

  15. Pharmacokinetics of Saquinavir, Atazanavir, and Ritonavir in a Twice-Daily Boosted Double-Protease Inhibitor Regimen▿

    Science.gov (United States)

    von Hentig, Nils; Müller, Axel; Rottmann, Carsten; Wolf, Timo; Lutz, Thomas; Klauke, Stephan; Kurowski, Michael; Oertel, Bruno; Dauer, Brenda; Harder, Sebastian; Staszewski, Schlomo

    2007-01-01

    The objective of this study was to evaluate the pharmacokinetics of atazanavir (ATV), saquinavir (SQV), and ritonavir (RTV) in a boosted double-protease inhibitor (PI) therapy regimen without reverse transcriptase inhibitors (RTIs). The study design was as follows. Patients with limited RTI options received a PI combination of 300/100 mg ATV/RTV once daily and 1,000 mg SQV twice daily (group 1; n = 49) without RTI comedication. The results were compared to the plasma concentrations of PIs of patients taking either 300 mg ATV/100 mg RTV once daily plus RTIs (group 2; n = 72) or patients taking 1,000 mg SQV/100 mg RTV plus RTIs (group 3; n = 90). The study methods were as follows. Patients were given a 12/24-h pharmacokinetic assessment at steady state. Drug concentrations were measured by liquid chromatography-tandem mass spectrometry. The minimum and maximum concentrations (Cmin and Cmax), area under the concentration-time curve under steady-state conditions (AUCss), elimination half-life, time of maximum concentration and lag time were subject to statistical analysis. The results show that patients treated with ATV/SQV/RTV exhibited significantly high SQV concentrations and moderate enhancement of the AUCss of ATV in comparison to those of patients of the control groups: for SQV in groups 1 and 3, the geometric mean (GM) of the AUCss was 22,794 versus 15,759 ng·h/ml (GM ratio [GMR] = 1.45; P < 0.05), the GM of the Cmax was 3,257 versus 2,331 ng/ml (GMR = 1.40; P < 0.05), and the GM of the Cmin was 438 versus 437 ng/ml (GMR = 1.00); for ATV in groups 1 and 2, the GM of the AUCss was 39,154 versus 33,626 ng·h/ml (GMR = 1.16), the GM of the Cmax was 3,488 versus 2,924 ng/ml (GMR = 1.20), and the GM of the Cmin was 515 versus 428 ng/ml (GMR = 1.21). RTV levels were comparable for all groups. A subgroup analysis detected only marginal differences in ATV plasma exposure if combined with tenofovir-disoproxilfumarate and without it. We conclude that our pharmacokinetic

  16. Studying Extrachromosomal Genetic Elements in Sulfolobus

    DEFF Research Database (Denmark)

    Guannan, Liu

    facilitated the characterization of viruses, plasmids and membrane vesicles. Studying the interactions between Sulfolobus and extrachromosomal genetic elements has provided many new insights into basic molecular processes. Secreted membrane vesicle seems to be a common characteristic for Sulfolobus. In order...... of random chromosomal fragments, including IS elements. The results suggest that membrane vesicles could serve as vehicles for the inter-cellular transport of genetic material. A variant of ATV, ATV2, was isolated that infected a newly isolated Sulfolobus solfataricus P3 strain. Comparative genomics......, whereas the deactivation of pKEF9 in S. solfataricus was caused by mobile elements after it had integrated into the host genome....

  17. Studying Extrachromosomal Genetic Elements in Sulfolobus

    DEFF Research Database (Denmark)

    Guannan, Liu

    facilitated the characterization of viruses, plasmids and membrane vesicles. Studying the interactions between Sulfolobus and extrachromosomal genetic elements has provided many new insights into basic molecular processes. Secreted membrane vesicle seems to be a common characteristic for Sulfolobus. In order...... of random chromosomal fragments, including IS elements. The results suggest that membrane vesicles could serve as vehicles for the inter-cellular transport of genetic material. A variant of ATV, ATV2, was isolated that infected a newly isolated Sulfolobus solfataricus P3 strain. Comparative genomics......, whereas the deactivation of pKEF9 in S. solfataricus was caused by mobile elements after it had integrated into the host genome....

  18. Combining Performance and Flexibility for RMS with a Hybrid Architecture

    NARCIS (Netherlands)

    Arjan van Zanten; Dick van der Steen; Dennis Koole; Ing. Erik Puik; Patrick Wit; Pascal Muller; Leo van Moergestel; Arjan Groenewegen; John-Jules Meyer; Daniël Telgen

    2013-01-01

    Author supplied Combining Performance and Flexibility for RMS with a Hybrid Architecture Dani¨el Telgen 12? , Leo van Moergestel 1 , Erik Puik 1 , Pascal Muller 1 , Arjan Groenewegen 1 , Dick van der Steen 1 , Dennis Koole 1 , Patrick de Wit 1 , Arjen van Zanten 1 , and John-Jules

  19. The JHR reactor: a multipurpose asset for materials; Le reacteur RHJ: polyvalence au service des materiaux

    Energy Technology Data Exchange (ETDEWEB)

    Iracane, D.; Yvon, P. [CEA Saclay, Dir. de l' Energie Nucleaire, 91 - Gif sur Yvette (France)

    2007-07-01

    The creeping obsolescence of experimental irradiation reactors around the world, in the European Union in particular, means that the Jules Horowitz Reactor (JHR), due to be commissioned by CEA in 2014, at Cadarache, is an essential addition, whether it be for the investigation of materials, or of novel fuels. Its capabilities extend beyond the requirements of investigations relating to fourth-generation systems. (authors)

  20. Getting Smarter at Managing Avionic Software: The Results of a Two-Day Requirements Elicitation Workshop With DTAES

    Science.gov (United States)

    2007-10-01

    Charpentier, Robert; Salois, Martin; Bergeron, Jean; Debbabi, Mourad; Desharnais, Jules; Giasson, Emmanuel ; Ktari, Béchir; Michaud, Frédéric, and Tawbi...Security Establishment (CSE). Ottawa, Canada: (CSE). Read the PDF. 5. Shepard, Terry; Kelly, Diane; Smith, Ron; Chisholm, Ron; Jackson, Todd , and Mondoux

  1. Anmeldelse af: Afghantsy. The Russians in Afghanistan 1979-89

    DEFF Research Database (Denmark)

    Vestenskov, David

    2012-01-01

    Baseret på nyligt afklassificeret materiale fra arkiverne i Moskva samt fremstillinger af russiske historikere, tegnes et anderledes og mere nuanceret billede af de sovjetiske erfaringer fra Afghanistan. De første spadestik til opgøret med den amerikanske stempling af den sovjetiske ageren i jule...

  2. Combining Performance and Flexibility for RMS with a Hybrid Architecture

    NARCIS (Netherlands)

    Telgen, Daniël; Moergestel, Leo van; Puik, Erik; Muller, Pascal; Groenewegen, Arjan; Steen, Dick van der; Koole, Dennis; Wit, Patrick; Zanten, Arjan van; Meyer, John-Jules

    2013-01-01

    Author supplied Combining Performance and Flexibility for RMS with a Hybrid Architecture Dani¨el Telgen 12? , Leo van Moergestel 1 , Erik Puik 1 , Pascal Muller 1 , Arjan Groenewegen 1 , Dick van der Steen 1 , Dennis Koole 1 , Patrick de Wit 1 , Arjen van Zanten 1 , and John-Jules Meyer 2 1 Departm

  3. Katalog: Malerier, skulpturer, pasteller, tegninger

    DEFF Research Database (Denmark)

    Anderberg, Birgitte

    2011-01-01

    Tekster om Ordrupgaards samling af værker af Albert André, Anonym, Louis Anquetin, Antoine-Louis Barye, Eugène Boudin, Paul Cézanne, Camille Corot, Gustave Courbet, Thomas Couture, Charles-Francois Daubigny, Karl Daubigny, Honoré Daumier, Charles Despiiau, Diaz de la Peña, Jules Dupré, Théodore...

  4. Maine de Biran: The Relationship between the Physical and the Moral in Man

    NARCIS (Netherlands)

    Meacham, Darian

    2016-01-01

    Maine de Biran's work has had an enormous influence on the development of French Philosophy – Henri Bergson called him the greatest French metaphysician since Descartes and Malebranche, Jules Lachelier referred to him as the French Kant, and Royer-Collard called him simply 'the master of us all' – a

  5. "Sugar" jõuab lavale / Ülle Hallik

    Index Scriptorium Estoniae

    Hallik, Ülle, 1963-

    2008-01-01

    Vanemuises esietendub 5. juunil "Sugar", lavastaja Mare Tommingas. Muusikal põhineb Jule Styne muusikalil "Sugar ehk Dzhässis ainult tüdrukud". Muusikali libreto kirjutas Peter Stone Robert Thoereni jutustuse ning Billy Wilderi ja I. A. L. Dimanondi filmi "Some Like It Hot" põhjal

  6. "Does Broca's Area Exist?:" Christofredo Jakob's 1906 Response to Pierre Marie's Holistic Stance

    Science.gov (United States)

    Tsapkini, Kyrana; Vivas, Ana B.; Triarhou, Lazaros C.

    2008-01-01

    In 1906, Pierre Marie triggered a heated controversy and an exchange of articles with Jules Dejerine over the localization of language functions in the human brain. The debate spread internationally. One of the timeliest responses, that appeared in print 1 month after Marie's paper, came from Christofredo Jakob, a Bavarian-born neuropathologist…

  7. The Film. The Bobbs-Merrill Series in Composition and Rhetoric.

    Science.gov (United States)

    Sarris, Andrew, Ed.

    Prefaced by a brief discussion of early films and film criticism, 10 essays treat selected modern directors and their works. Essays on Stanley Kubrick's "Lolita," the early works of Elia Kazan, and the response of French critics to Jerry Lewis explore the American scene, while Francois Truffaut's "Jules and Jim," the early work of Robert Bressen,…

  8. Academic Achievement, Pupil Participation and Integration of Group Work Skills in Secondary School Classrooms in Trinidad and Barbados

    Science.gov (United States)

    Layne, Anthony; Jules, Vena; Kutnick, Peter; Layne, Clarissa

    2008-01-01

    Studies have shown a positive relationship between a rise in schooling levels and economic production [World Bank, 2005. A Time to Choose: Caribbean Development in the 21st Century. World Bank, Washington, DC; Jules, V., Panneflek, A., 2000. EFA in the Caribbean: Assessment 2000, Sub-Regional Report, vol. 2, The State of Education in the Caribbean…

  9. Maine de Biran: The Relationship between the Physical and the Moral in Man

    NARCIS (Netherlands)

    Meacham, Darian

    2016-01-01

    Maine de Biran's work has had an enormous influence on the development of French Philosophy – Henri Bergson called him the greatest French metaphysician since Descartes and Malebranche, Jules Lachelier referred to him as the French Kant, and Royer-Collard called him simply 'the master of us all' –

  10. The Film. The Bobbs-Merrill Series in Composition and Rhetoric.

    Science.gov (United States)

    Sarris, Andrew, Ed.

    Prefaced by a brief discussion of early films and film criticism, 10 essays treat selected modern directors and their works. Essays on Stanley Kubrick's "Lolita," the early works of Elia Kazan, and the response of French critics to Jerry Lewis explore the American scene, while Francois Truffaut's "Jules and Jim," the early work of Robert Bressen,…

  11. "Sugar" jõuab lavale / Ülle Hallik

    Index Scriptorium Estoniae

    Hallik, Ülle, 1963-

    2008-01-01

    Vanemuises esietendub 5. juunil "Sugar", lavastaja Mare Tommingas. Muusikal põhineb Jule Styne muusikalil "Sugar ehk Dzhässis ainult tüdrukud". Muusikali libreto kirjutas Peter Stone Robert Thoereni jutustuse ning Billy Wilderi ja I. A. L. Dimanondi filmi "Some Like It Hot" põhjal

  12. Maine de Biran: The Relationship between the Physical and the Moral in Man

    NARCIS (Netherlands)

    Meacham, Darian

    2016-01-01

    Maine de Biran's work has had an enormous influence on the development of French Philosophy – Henri Bergson called him the greatest French metaphysician since Descartes and Malebranche, Jules Lachelier referred to him as the French Kant, and Royer-Collard called him simply 'the master of us all' – a

  13. Celebration Capitalism

    OpenAIRE

    Boykoff, Jules

    2014-01-01

    Capitalism is a nimble shapeshifter. In this talk Jules Boykoff draws from the history of the Olympic Games to offer a theory of “celebration capitalism,” a form of modern-day economics that complements Naomi Klein’s “disaster capitalism” marked by neoliberalism: privatization, deregulation, and free-market rhetoric.

  14. Evaluation of modelled methane emissions over northern peatland sites

    Science.gov (United States)

    Gao, Yao; Burke, Eleanor; Chadburn, Sarah; Raivonen, Maarit; Susiluoto, Jouni; Vesala, Timo; Aurela, Mika; Lohila, Annalea; Aalto, Tuula

    2017-04-01

    Methane (CH4) is a powerful greenhouse gas, with approximately 34 times the global warming potential of carbon dioxide (CO2) over a century time horizon (IPCC, 2013). The strong sensitivity of methane emissions to environmental factors has led to concerns about potential positive feedbacks to climate change. Evaluation of the ability of the process-based land surface models of earth system models (ESMs) in simulating CH4 emission over peatland is needed for more precise future predictions. In this study, two peatland sites of poor and rich soil nutrient conditions, in southern and northern Finland respectively, are adopted. The measured CH4 fluxes at the two sites are used to evaluate the CH4 emissions simulated by the land surface model (JULES) of the UK Earth System model and by the Helsinki peatland methane emission model (HIMMELI), which is developed at Finnish Meteorological Institute and Helsinki University. In JULES, CH4 flux is simply related to soil temperature, wetland fraction and effective substrate availability. However, HIMMELI has detailed descriptions of microbial and transport processes for simulating CH4 flux. The seasonal dynamics of CH4 fluxes at the two sites are relatively well captured by both models, but model biases exist. Simulated CH4 flux is sensitive to water table depth (WTD) at both models. However, the simulated WTD is limited to be below ground in JULES. It is also important to have the annual cycle of LAI correct when coupling JULES with HIMMELI.

  15. Beskrivelse af næringsstofomsætning med metabolomics

    DEFF Research Database (Denmark)

    Hedemann, Mette Skou

    2010-01-01

    I et forsøg med mink med lav eller høj foderkonvertering er der blevet taget blodprøver på tre tidspunkter. Blodprøverne er blevet taget i en periode, hvor minkene er blevet fodret restriktivt (en prøve) og i en periode med ad libitum fodring (to prøver). Blodprøverne blev analyseret ved hjælp af...... fra restriktivt fodrede mink end i plasma fra ad libitum fodrede mink - betain og carnitin. Derudover er der en lang række andre metabolitter, som også findes i forskellig koncentration som endnu ikke er identificeret....

  16. Towards a simple representation of chalk hydrology in land surface modelling

    Science.gov (United States)

    Rahman, Mostaquimur; Rosolem, Rafael

    2017-01-01

    Modelling and monitoring of hydrological processes in the unsaturated zone of chalk, a porous medium with fractures, is important to optimize water resource assessment and management practices in the United Kingdom (UK). However, incorporating the processes governing water movement through a chalk unsaturated zone in a numerical model is complicated mainly due to the fractured nature of chalk that creates high-velocity preferential flow paths in the subsurface. In general, flow through a chalk unsaturated zone is simulated using the dual-porosity concept, which often involves calibration of a relatively large number of model parameters, potentially undermining applications to large regions. In this study, a simplified parameterization, namely the Bulk Conductivity (BC) model, is proposed for simulating hydrology in a chalk unsaturated zone. This new parameterization introduces only two additional parameters (namely the macroporosity factor and the soil wetness threshold parameter for fracture flow activation) and uses the saturated hydraulic conductivity from the chalk matrix. The BC model is implemented in the Joint UK Land Environment Simulator (JULES) and applied to a study area encompassing the Kennet catchment in the southern UK. This parameterization is further calibrated at the point scale using soil moisture profile observations. The performance of the calibrated BC model in JULES is assessed and compared against the performance of both the default JULES parameterization and the uncalibrated version of the BC model implemented in JULES. Finally, the model performance at the catchment scale is evaluated against independent data sets (e.g. runoff and latent heat flux). The results demonstrate that the inclusion of the BC model in JULES improves simulated land surface mass and energy fluxes over the chalk-dominated Kennet catchment. Therefore, the simple approach described in this study may be used to incorporate the flow processes through a chalk unsaturated

  17. 50 CFR 32.43 - Mississippi.

    Science.gov (United States)

    2010-10-01

    ... Game Hunting. We allow hunting of quail, squirrel, rabbit, beaver, nutria, raccoon, coyotes, and..., coyote, beaver, bobcat, and nutria. 10. We allow ATVs only on designated trails (see §27.31 of this... for that hunt: raccoon, opossum, coyote, beaver, bobcat, and nutria. 10. We allow shotguns with only...

  18. Changing the Cultural Paradigm to Meet Emerging Requirements

    Science.gov (United States)

    Robbins, William W.

    2007-01-01

    This viewgraph presentation reviews changes that are required in Space Transportation. This new transportation paradigm from the reliance on the Space Shuttle to a mixture of space transportation vehicles, i.e., the Russian Progress, vehicle, the Japanese HTV, the European ATV and other commercial orbital transportation systems, requires a new cultural paradigm. This new paradigm is outlined, and reviewed.

  19. Therapeutic drug monitoring of atazanavir/ritonavir in pregnancy.

    LENUS (Irish Health Repository)

    Else, L J

    2014-11-01

    Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir\\/ritonavir (ATV\\/r) plasma concentrations in a cohort of pregnant women undergoing routine therapeutic drug monitoring (TDM).

  20. System for performing site characterization for test ranges containing unexploded ordnance

    Science.gov (United States)

    Brown, H. Edward; Crane, Carl D., III

    1996-05-01

    Wright Laboratory has been tasked by the Naval Explosive Ordnance Technical Division to develop robotic platforms to perform characterization of areas set aside for ordnance testing. These areas require the identification and removal of the unexploded ordnance before they can be utilized for safe, productive use. The characterization task is performed by autonomously sweeping a designated area with the autonomous tow vehicle (ATV). The ATV tows the multiple sensor platform containing a magnetometer array and a ground penetrating radar. The ATV provides the time and position stamp for sensor data. Analysts then review the post survey sensor data to determine ordnance position. The ATV makes use of several advanced technologies. A hybrid navigation and guidance system using an external Kalman filter delivers vehicle position based on information from a real time centimeter level differential global positioning system and a strapped down laser gyro inertial navigation system. A vision-based obstacle avoidance system helps to account for unknown obstacles during survey. Sophisticated path planning algorithms, and an intelligent software architecture for planning and behavior provide a measure of autonomy. A data collection system controls the functions of the various sensors used for the characterization process and manipulates the data stream to conform to an open ASCII data format and stores it to rugged removable hard disks for later analysis.

  1. Social Capital in an Outdoor Recreation Context

    Science.gov (United States)

    Mann, Marilynne; Leahy, Jessica

    2010-02-01

    This study examined social capital development in three all-terrain vehicles (ATV) clubs in Maine using an adapted version of Lin’s (2001) social capital theory model. The structural components of social capital identified included collective assets and individual assets in the form of normative behavior and trust relationships. Also identified were counter-norms for individual ATV riders identified as having divergent norms from club members. The second component of social capital is access to and mobilization of network contacts and resources. Access networks in the context of the ATV clubs studied were identified as community and landowner relations while mobilization of resources was existent in club membership attempts toward self-governance and efforts of the statewide “umbrella” organization. Instrumental outcomes benefit society and expressive outcomes benefit the individual. Both types of returns are present in the data suggesting that ATV clubs are creating social capital. This is important information to clubs who desire to market themselves, improve their reputations, and enhance their volunteer association. It is of further interest to state governments who fund clubs through trail grants as proof that a return on investment is being realized. Theoretical and applied implications for these and other types of recreation-based volunteer associations (e.g., clubs, friends groups, advocacy groups) are presented.

  2. U.S. EPA and Customs joint operations at California Ports results in illegal vehicles and engines seized or turned back at border

    Science.gov (United States)

    LOS ANGELES - Today, the U.S. Environmental Protection Agency and U.S. Customs and Border Protection announced $94,700 in fines and more than 1,394 items, including engines, scooters and ATVs, that were recently seized, exported out of the country,

  3. 75 FR 5767 - All Terrain Vehicle Chinese Language Webinar; Meeting

    Science.gov (United States)

    2010-02-04

    ... COMMISSION All Terrain Vehicle Chinese Language Webinar; Meeting AGENCY: Consumer Product Safety Commission... Terrain Vehicle Chinese Language Webinar. The webinar will focus on CPSC's requirements for ATV's... February 4, 2010 at 6:00 am Eastern Standard Time. Location: The meeting will be held live via...

  4. Motorcycle Mechanic: Apprenticeship Course Outline. Apprenticeship and Industry Training. 4912

    Science.gov (United States)

    Alberta Enterprise and Advanced Education, 2012

    2012-01-01

    The graduate of the Motorcycle Mechanic apprenticeship program is a certified journeyperson who will be able to: (1) repair and maintain motorcycles and ATVs which are powered with internal combustion engines; (2) comprehend work orders, technical bulletins and estimates, and relate the information to the job at hand; (3) interpret warranty policy…

  5. 75 FR 32205 - Felsenthal National Wildlife Refuge, Ashley, Bradley, and Union Counties, AR; Overflow National...

    Science.gov (United States)

    2010-06-07

    ... species of plants and animals, refuge access, law enforcement, and environmental education and... populations and invasive plant species would be undertaken on an opportunistic basis. Habitat management... continue to include the use of ATVs along designated trails. Hunters with disabilities would still be...

  6. 75 FR 26714 - Notice of Proposed New Recreation Fee Site; Federal Lands Recreation Enhancement Act, (Title VIII...

    Science.gov (United States)

    2010-05-12

    ... ATV Trail is located near Beaumont, MS. Currently, the site contains 31 miles of trail, an information.... This annual pass could be used for access to three other motorized trails in the National Forests in... recreational experience at the facility. Comparable recreational use fees are being proposed at other...

  7. Características fisiológicas de microtomateiros fitocromo-mutantes Physiological characteristics of micro-tomato (Lycopersicon esculentum P. Miller) phytochrome-mutants

    National Research Council Canada - National Science Library

    Hyrandir Cabral de Melo; Evaristo Mauro de Castro; Ângela Maria Soares; Cynthia de Oliveira; Sílvio Júnio Ramos

    2009-01-01

    ... (Lycopersicon esculentum P. Miller cv. Micro-Tom) fitocromo-mutantes. A cultivar Micro-Tom e os mutantes aurea (deficiente na biossíntese do cromóforo dos fitocromos), atroviolacea (atv) e high pigment1 (hp1...

  8. WWTP design in warm climates - guideline comparison and parameter adaptation for a full-scale activated sludge plant using mass balancing.

    Science.gov (United States)

    Walder, C; Lindtner, S; Proesl, A; Klegraf, F; Weissenbacher, N

    2013-01-01

    The ATV-A-131 guideline and the design approach published in 'Wastewater Engineering, Treatment and Reuse (WE)' are widely used for the design of activated sludge plants. They are both based on simplified steady-state assumptions tailored to the boundary conditions of temperate climates. Using design guidelines beyond the designated temperature range may lead to inappropriate results. The objectives of this paper are (1) to summarise temperature relevant differences between ATV-A-131 and WE; (2) to show the related design components; and (3) to demonstrate a procedure for design parameter adaptation for a full-scale activated sludge plant located in a warm climate region. To gain steady-state data required for wastewater treatment plant (WWTP) design according to ATV-A-131 and WE, full-scale plant data were acquired for a period of 6 months as a basis for analyses and adaptation. Mass balances were calculated for the verification of the measurements and for analysing excess sludge production. The two approaches showed relevant temperature related differences. WE default application resulted in lower deviation in the mass balance results for excess sludge production. However, with the adaptation of the heterotrophic decay rates for both approaches and the inert organic and mineral solids fraction additionally for ATV-A-131, a good fit to the observed excess sludge production could be achieved.

  9. Development and validation of HPLC and CE methods for simultaneous determination of amlodipine and atorvastatin in the presence of their acidic degradation products in tablets

    Directory of Open Access Journals (Sweden)

    Hassan Said A.

    2016-12-01

    Full Text Available Two methods were developed for separation and quantitation of amlodipine (AML and atorvastatin (ATV in the presence of their acidic degradation products. The first method was a simple isocratic RP-HPLC method while the second was capillary electrophoresis (CE. Degradation products were obtained by acidic hydrolysis of the two drugs and their structures were elucidated for the first time by IR and MS spectra. Degradation products did not interfere with the determination of either drug and the assays were therefore stability-indicating. The linearity of the proposed methods was established over the ranges 1-50 μg mL-1 for AML and ATV in the HPLC method and in the range of 3-50 and 4-50 μg mL-1 for AML and ATV, respectively, in the CE method. The proposed methods were validated according to ICH guidelines. The methods were successfully applied to estimation of AML and ATV in combined tablets.

  10. Final Report: Education, Public Access, and Outdoor Recreation

    Science.gov (United States)

    1993-09-01

    recreational activity. The Motorcycle Industry Council, Inc. (1991) estimated that 31 million people operated a motorcycle, scooter , or ATV during 1990. This...except when it is found the overriding milita-y mission specifically requires a temporary or permanent suspension of such use (AFR 126-1). 101. Air

  11. The Science of Soil Textures

    Science.gov (United States)

    Bigham, Gary

    2010-01-01

    Off-road motorcycle racing and ATV riding. Gardening and fishing. What do these high-adrenaline and slower-paced pastimes have in common? Each requires soil, and the texture of that soil has an effect on all of them. In the inquiry-based lessons described here, students work both in the field or laboratory and in the classroom to collect soil…

  12. All-terrain vehicle injuries in central Wisconsin: a continuing problem.

    Science.gov (United States)

    Stueland, D; Aldrich, R

    1991-06-01

    All-terrain vehicles (ATVs) have become well recognized as associated with injuries. This recognition has resulted in attempts at education and regulation to reduce the number and severity of injuries and number of deaths. The Marshfield Clinic and St. Joseph's Hospital surveyed all-terrain vehicle accidents in the Emergency Department in 1985 and again in 1988 and followed these patients for at least 1 year after the injury. Between the two dates, extensive educational and legislative activity had taken place. The actual number of all-terrain vehicle accidents had increased. The characteristics of victims who were involved in all-terrain vehicle accidents did not change. The actual number of accidents associated with three-wheeled ATVs did not appreciably decrease but the number of accidents associated with four-wheeled ATVs did increase. To date, it is not clear that legislative and educational activities are effective in reducing the number of ATV accidents or in changing the pattern of the accidents.

  13. Accumulation of anthocyanins in tomato skin extends shelf life.

    Science.gov (United States)

    Bassolino, Laura; Zhang, Yang; Schoonbeek, Henk-Jan; Kiferle, Claudia; Perata, Pierdomenico; Martin, Cathie

    2013-11-01

    Shelf life is one of the most important traits for the tomato (Solanum lycopersicum) industry. Two key factors, post-harvest over-ripening and susceptibility to post-harvest pathogen infection, determine tomato shelf life. Anthocyanins accumulate in the skin of Aft/Aft atv/atv tomatoes, the result of introgressing alleles affecting anthocyanin biosynthesis in fruit from two wild relatives of tomato, which results in extended fruit shelf life. Compared with ordinary, anthocyanin-less tomatoes, the fruits of Aft/Aft atv/atv keep longer during storage and are less susceptible to Botrytis cinerea, a major tomato pathogen, post-harvest. Using genetically modified tomatoes over-producing anthocyanins, we confirmed that skin-specific accumulation of anthocyanins in tomato is sufficient to reduce the susceptibility of fruit to Botrytis cinerea. Our data indicate that accumulation of anthocyanins in tomato fruit, achieved either by traditional breeding or genetic engineering can be an effective way to extend tomato shelf life.

  14. 50 CFR 32.39 - Maryland.

    Science.gov (United States)

    2010-10-01

    ... access we allow is walk-in or bicycles. We prohibit access by boats or ATVs. 14. We only allow scouting...: a. You may use car-top boats 14 feet (4.2 m) or less, and canoes. b. You may only use electric...

  15. Investigation into Contact Resistance And Damage of Metal Contacts Used in RF-MEMS Switches

    Science.gov (United States)

    2009-09-01

    Colonel, USAF Approved: Dr. Shankar Mall (Chairman) date Dr. Jonathan Black (Member) date Maj. LaVern Starman, PhD (Member) date Dr. Michael Heil (Member...selection technique. v Acknowledgements I would like to thank my advisor, Dr. Shankar Mall, for his assistance and advice during this project. I would also...van Ruitenbeek. “ Quantum properties of atomic-sized conductors,” Physics Reports, 377:81–279, 2003. 4. Almeida, L., R. Ramadoss, R. Jackson, K

  16. FAA (Federal Aviation Administration) Air Traffic Activity FY 1982,

    Science.gov (United States)

    1982-09-30

    CkROMA (L661 CA 118 0 0 118 0 EL MONTE (ENT) CA 11-3 0 31 1695 Li VERNE BRACKETT ( POCI CA 1?90 0 0 1705 I ONTARIO (O6TI CA II3n9 0907 2192 3090 3b8 £I...information, receive and close flight plans, monitor radio NAVAIDS, notify search and rescue units of missing VFR aircraft and operate the national

  17. Permeabilitetsforsøg på vækstjord

    DEFF Research Database (Denmark)

    Lund, Willy; Ibsen, Lars Bo

    Hydrauliske egenskaber for vækstjord fremstillet af Dansand i Silkeborg ønskes bestemt. Til disse undersøgelser modtog Laboratoriet for Fundering den 26. juni 2002 ni stk. poseprøver benævnt prøve 1 til 9. Jordprøverne blev opbevaret i lukkede plastsække for at beholde den naturlige fugt i jorden...

  18. Rømø

    DEFF Research Database (Denmark)

    Thorsen, Grete; Ibsen, Lars Bo

    Denne datarapport indeholder resultater af konsolideringsforsøg med tre prøver af ler fra Miocæn. Prøverne er udtaget fra kerner fra en geologisk undersøgelsesboring udført i 1998 af Danmarks og Grønlands Geologiske Undersøgelse (GEUS), boring 148.51/52.  Det væsentligste formål med forsøgene har...

  19. Permeabilitetsforsøg på vækstjord

    DEFF Research Database (Denmark)

    Lund, Willy; Ibsen, Lars Bo

    Hydrauliske egenskaber for vækstjord fremstillet af Dansand i Silkeborg Ønskes bestemt. Til disse undersøgelser modtog Laboratoriet for Fundering i marts 2002 tre stk. poseprøver benævnt prøve 1, 2 og 3. Jordprøverne blev opbevaret i lukkede plastsække for at beholde den naturlige fugt i jorden. ...

  20. La izquierda Argentina: nuevamente el fracaso

    Directory of Open Access Journals (Sweden)

    Ángel Rodríguez Kauth

    2004-01-01

    Full Text Available A partir de los acontecimientos políticos y sociales ocurridos en Argentina desde finales de 2001, se estudia el papel protagónico que tuvieron las diversas organizaciones en que se ha atomizado la izquierda vernácula. Esto es no sólo en el plano electoral, sino también en el de las movilizaciones junto a la participación popular que reclamaba su presencia.

  1. 安全测试平台进入国家战略视野

    Institute of Scientific and Technical Information of China (English)

    杨望

    2010-01-01

    @@ 2009年8月10日,在加拿大的蒙特利尔召开了第二届网络安全实验和测试讨论会(workshop on Cyber security Experimentation and Test),尽管这个讨论会规模不大,却聚集了国际知名大学的安全研究专家Paul Bafford、Vern Paxson 等.

  2. Scalable Wavelet-Based Active Network Stepping Stone Detection

    Science.gov (United States)

    2012-03-22

    Joseph I. Gilbert, B.S. Eng. Physics Major, USA Approved: Lt Col David J. Robinson, PhD (Chairman) Date Major Jonathan W. Butts, PhD (Committee Member...UNIVERSITY OF ILLINOIS, 1998. [5] Donoho, David L., Ana Georgina Flesia, Umesh Shankar, Vern Paxson, Jason Coit, and Stuart Staniford. “Multiscale stepping...Schnackenberg, Harley Holliday, and Travis Reid. “Autonomic Response to Distributed Denial of Service Attacks”. Proceedings of the 4th International Symposium

  3. Byen som bevægelsesgrund?

    DEFF Research Database (Denmark)

    Højbjerre Larsen, Signe

    2013-01-01

    Parkour er en bevægelseskultur der ikke udfolder sig i afgrænsede rum eller på bestemte tidspunkter. Den er i stedet betinget af at byens rum anvendes som bevægelsesgrund. Parkourudøvernes særegne brug af byrummet kalder på opmærksomhed og analytisk undren: Hvordan kan vi forstå et fænomen som pa...

  4. Byen som bevægelsesgrund?

    DEFF Research Database (Denmark)

    Højbjerre Larsen, Signe

    2013-01-01

    Parkour er en bevægelseskultur der ikke udfolder sig i afgrænsede rum eller på bestemte tidspunkter. Den er i stedet betinget af at byens rum anvendes som bevægelsesgrund. Parkourudøvernes særegne brug af byrummet kalder på opmærksomhed og analytisk undren: Hvordan kan vi forstå et fænomen som pa...

  5. Relation between creative teaching and sustainable practices in cultural heritage tourism

    OpenAIRE

    Rašperić Ružica; Lekić Romana; Fištrek Lidija

    2016-01-01

    This paper is primarily concerned with alternative teaching methodologies. Creative teaching methodologies place the student at the center of the learning process. This paper is a case study of 'Orion - promotion of the Vučedol culture' project as a self-sustainable cultural product. The primary goal of the project is the promotion of heritage through cultural tourism. The 'Orion' project was launched in cooperation with third year undergraduate students at the Department of Tourism of VERN U...

  6. Volunteers as explainers at the Finnish Science Centre Heureka

    Directory of Open Access Journals (Sweden)

    Marjatta Väkeväinen

    2005-12-01

    Full Text Available Heureka is situated in the Helsinki Metropolitan area. Every year, on average, 300.000 visitors come to Heureka; it is one of the largest year-round attractions in the area. 20–25% of the visitors are school classes. Heureka has a main exhibition including Children’s Heureka and also always houses two temporary exhibitions. Special activities supplement the exhibitions: The Verne Theatre, Children’s Laboratory, The Open Laboratory, Science Theatre Minerva and the Basketball Rats.

  7. Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection

    Directory of Open Access Journals (Sweden)

    Crutchley RD

    2016-03-01

    Full Text Available Rustin D Crutchley,1 Rakesh C Guduru,2 Amy M Cheng1 1Department of Pharmacy Practice and Translational Research, College of Pharmacy, University of Houston, 2CompanionDX, Houston, TX, USA Abstract: Atazanavir/cobicistat (ATV/c and darunavir/cobicistat (DRV/c are newly approved once daily fixed-dose protease inhibitor combinations for the treatment of HIV-1 infection. Studies in healthy volunteers have established bioequivalence between cobicistat and ritonavir as pharmacoenhancers of both atazanavir (ATV and darunavir (DRV. In addition, two randomized clinical trials (one Phase II and one Phase III noninferiority trial with a 144-week follow-up period demonstrated that cobicistat had sustainable and comparable efficacy and safety to ritonavir as a pharmacoenhancer of ATV through 144 weeks of treatment in HIV-1-infected patients. Furthermore, one Phase III, open-label, single-arm, clinical trial reflected virologic and immunologic responses and safety outcomes consistent with prior published data for DRV/ritonavir 800/100 mg once daily, supporting the use of DRV/c 800/150 mg once daily for future treatment of treatment-naïve and -experienced HIV-1-infected patients with no DRV resistance-associated mutations. Low rates of virologic failure secondary to resistance to antiretroviral regimens were present in these clinical studies. Most notable adverse events in the ATV studies were hyperbilirubinemia and in the DRV study rash. Small increases in serum creatinine and minimally reduced estimated glomerular filtration rate Cockcroft–Gault calculation (eGFRCG were observed in ATV/c and DRV/c clinical studies consistent with other studies evaluating elvitegravir/cobicistat/tenofovir/emtricitabine for the treatment of HIV-1 infection. These renal parameter changes occurred acutely in the first few weeks and plateaued off for the remaining study periods and are not necessarily clinically relevant. Cobicistat has numerous advantages compared to

  8. Different origin of adipogenic stem cells influences the response to antiretroviral drugs

    Energy Technology Data Exchange (ETDEWEB)

    Gibellini, Lara; De Biasi, Sara; Nasi, Milena; Carnevale, Gianluca; Pisciotta, Alessandra; Bianchini, Elena; Bartolomeo, Regina [Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125 Modena (Italy); Polo, Miriam [Department of Pharmacology, University of Valencia, Av.da Blasco Ibáñez 15, Valencia (Spain); FISABIO–Hospital Universitario Dr. Peset, Av.da Gaspar Aguilar 90, Valencia (Spain); De Pol, Anto [Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125 Modena (Italy); Dipartimento Sperimentale Interaziendale, Campus San Lazzaro, University of Modena and Reggio Emilia, 42122 Reggio Emilia (Italy); Pinti, Marcello [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy); Cossarizza, Andrea, E-mail: andrea.cossarizza@unimore.it [Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125 Modena (Italy); Dipartimento Sperimentale Interaziendale, Campus San Lazzaro, University of Modena and Reggio Emilia, 42122 Reggio Emilia (Italy)

    2015-10-01

    Lipodystrophy (LD) is a main side effect of antiretroviral therapy for HIV infection, and can be provoked by nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs). LD exists in different forms, characterized by fat loss, accumulation, or both, but its pathogenesis is still unclear. In particular, few data exist concerning the effects of antiretroviral drugs on adipocyte differentiation. Adipose tissue can arise either from mesenchymal stem cells (MSCs), that include bone marrow-derived MSCs (hBM-MSCs), or from ectodermal stem cells, that include dental pulp stem cells (hDPSCs). To analyze whether the embryonal origin of adipocytes might impact the occurrence of different phenotypes in LD, we quantified the effects of several antiretroviral drugs on the adipogenic differentiation of hBM-MSCs and hDPSCs. hBM-MSCs and hDPSCs were isolated from healthy donors. Cells were treated with 10 and 50 μM stavudine (d4T), efavirenz (EFV), atazanavir (ATV), ritonavir (RTV), and ATV-boosted RTV. Viability and adipogenesis were evaluated by staining with propidium iodide, oil red, and adipoRed; mRNA levels of genes involved in adipocyte differentiation, i.e. CCAAT/enhancer-binding protein alpha (CEBPα) and peroxisome proliferator-activated receptor gamma (PPARγ), and in adipocyte functions, i.e. fatty acid synthase (FASN), fatty acid binding protein-4 (FABP4), perilipin-1 (PLIN1) and 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2), were quantified by real time PCR. We found that ATV, RTV, EFV, and ATV-boosted RTV, but not d4T, caused massive cell death in both cell types. EFV and d4T affected the accumulation of lipid droplets and induced changes in mRNA levels of genes involved in adipocyte functions in hBM-MSCs, while RTV and ATV had little effects. All drugs stimulated the accumulation of lipid droplets in hDPSCs. Thus, the adipogenic differentiation of human stem cells can be influenced by antiretroviral drugs, and depends, at least in

  9. Analysis of recurring sinking events of armored tracked vehicles along dirt roads in the agricultural periphery of the Gaza Strip

    Science.gov (United States)

    Roskin, Joel

    2013-04-01

    The second (Al-Aqsa) intifada (Arab violent uprising) which erupted across Israel in 2000 eventually led the Israel Defense Forces to deploy armored tracked vehicles (ATVs) (tanks, armored personal carriers, and D-9 bulldozers) within Israel's agricultural periphery of the Gaza Strip, following daily attempts by Arab terrorists and guerillas to penetrate Israel. Combat movement of the ATVs was mainly concentrated to dirt roads, between agricultural fields, wherever possible. As a result of semi-arid Mediterranean (climate) winter rains, annually averaging 250 - 350 mm, it was reported that ATVs often sank in muddy terrain. This study investigated what caused ATVs to sink. The main data collected concerning the types of vehicles that sank related to: land-use characteristics, soil type, and daily rainfall. Interviews with commanders were also conducted for additional details. Between the fall and spring, surveys and weekly / bi-weekly field soil cone penetrometer tests were conducted at ten sites with different pedological and land-use characteristics. The loess soils, especially in agricultural fields, were generally found to be conducive to ATV traffic, even shortly after rainstorms of 10-30 mm. However, following several rainfall events exceeding 10 mm, ATVs and tanks regularly sank into local topographic depressions in the undulating landscape. These consisted of short segments of dirt roads where runoff and suspended sediment collected. After the early rains in late fall, tank ruts fossilize and become conduits of concentrated runoff and fine particles eroded by ATV activity during the summer months. Tank track ruts that formed in mud, compacted the soil, drastically altered drainage patterns by directing significant surface flow, and suspended sediment into these depressions, creating "tank-traps" whose trafficability ranged from "untrafficable" to "trafficable with constraints." This study shows that intense, routine, defensive military activity operated

  10. Safety profile of HIV-1 attachment inhibitor prodrug BMS-663068 in antiretroviral-experienced subjects: week 24 analysis

    Directory of Open Access Journals (Sweden)

    Jacob Lalezari

    2014-11-01

    Full Text Available Introduction: BMS-663068 is a prodrug of BMS-626529, an attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into the host CD4+ T-cell. AI438011 is an ongoing, Phase IIb, randomized, active-controlled trial investigating the safety, efficacy and dose–response of BMS-663068 vs. atazanavir/ritonavir (ATV/r in treatment-experienced (TE, HIV-1-positive subjects. At Week 24, response rates across the BMS-663068 arms were consistent with ATV/r. Materials and Methods: Antiretroviral TE subjects (exposure to ≥1 antiretroviral for ≥1 week with susceptibility to all study drugs (including BMS-626529 IC50 100 nM were randomized equally to four BMS-663068 arms (400 or 800 mg, BID; 600 or 1200 mg, QD and a control arm (ATV/r 300/100 mg QD, with tenofovir disoproxil fumarate (TDF + raltegravir (RAL. The complete safety profile through Week 24 is reported. Results: In total, 251 subjects were treated (BMS-663068, 200; ATV/r, 51. No BMS-663068-related adverse events (AEs led to discontinuation. Grade 2–4 drug-related AEs occurred in 17/200 (8.5% subjects across the BMS-633068 arms; however, these events were mostly single instances and no dose-relationship was seen. Similarly, no noticeable trend for Grade 3–4 laboratory abnormalities was seen and Grade 3–4 hematologic changes and liver chemistry elevations were uncommon (neutropenia, 2.5%; AST/ALT elevations, 1% (n=196. In the ATV/r arm, Grade 2–4 drug-related AEs occurred in 14/51 (27.5% subjects and were mostly secondary to gastrointestinal and/or hepatobiliary disorders. Serious adverse events (SAEs occurred in 13/200 (6.5% and 5/51 (9.8% subjects receiving BMS-663068 and ATV/r, respectively; most were secondary to infections and none were related to study drugs. The most common AE reported for BMS-663068 was headache (28/200, 14%, occurring in 5/51 (10% subjects in the ATV/r arm; in the BMS-663068 arms, this was not dose-related. There were no

  11. Uma outra ideia da Índia. As literaturas nas línguas Bhashas

    Directory of Open Access Journals (Sweden)

    Cielo Griselda Festino

    2013-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2013v1n31p103 O objetivo deste artigo é discutir as narrativas indianas nas línguas bhashas, as línguas vernáculas do subcontinente indiano a través de uma política e poética da tradução que da voz e visibilidade a culturas que, de outro modo, estariam restringidas às diversas culturas onde são produzidas. Dessa maneira, não só as literaturas do “front yard”, ou seja as narrativas indianas escritas na língua inglesa da diáspora ganham visibilidade, mas também as narrativas escritas do “backyard” nas línguas vernáculas  da Índia. Nesse processo, o termo “vernáculo” ganha um novo significado no sentido que o que é realmente “vernacularizado” é a língua  inglesa porque se torna um veículo por meio do que as literaturas bhasha tornam-se conhecidas. Para ilustrar esse processo o artigo traz uma análise do conto “Thayyaal” escrito na língua Tamil, do sul da Índia.

  12. Tension Structure

    Science.gov (United States)

    1978-01-01

    The fabric structure pictured is the Campus Center of La Verne College, La Verne, California. Unlike the facilities shown on the preceding pages, it is not air-supported. It is a "tension structure," its multi-coned fabric membrane supported by a network of cables attached to steel columns which function like circus tent poles. The spider-web in the accompanying photo is a computer graph of the tension pattern. The designers, Geiger-Berger Associates PC, of New York City, conducted lengthy computer analysis to determine the the best placement of columns and cables. The firm also served as structural engineering consultant on the Pontiac Silverdome and a number of other large fabric structures. Built by Birdair Structures, Inc., Buffalo, New York, the La Verne Campus Center was the first permanent facility in the United States enclosed by the space-spinoff fabric made of Owens-Corning Beta fiber glass coated with Du Pont Teflon TFE. The flexible design permits rearrangement of the interior to accommodate athletic events, student activities, theatrical productions and other recreational programs. Use of fabric covering reduced building cost 30 percent below conventional construction.

  13. Long-term effectiveness of unboosted atazanavir plus abacavir/lamivudine in subjects with virological suppression: A prospective cohort study.

    Science.gov (United States)

    Llibre, Josep M; Cozzi-Lepri, Alessandro; Pedersen, Court; Ristola, Matti; Losso, Marcelo; Mocroft, Amanda; Mitsura, Viktar; Falconer, Karolin; Maltez, Fernando; Beniowski, Marek; Vullo, Vincenzo; Hassoun, Gamal; Kuzovatova, Elena; Szlavik, János; Kuznetsova, Anastasiia; Stellbrink, Hans-Jürgen; Duvivier, Claudine; Edwards, Simon; Laut, Kamilla; Paredes, Roger

    2016-10-01

    Effectiveness data of an unboosted atazanavir (ATV) with abacavir/lamivudine (ABC/3TC) switch strategy in clinical routine are scant.We evaluated treatment outcomes of ATV + ABC/3TC in pretreated subjects in the EuroSIDA cohort when started with undetectable plasma HIV-1 viral load (pVL), performing a time to loss of virological response (TLOVR 50 copies/mL.We included 285 subjects, 67% male, with median baseline CD4 530 cells, and 44 months with pVL ≤50 copies/mL. The third drug in the previous regimen was ritonavir-boosted atazanavir (ATV/r) in 79 (28%), and another ritonavir-boosted protease inhibitor (PI/r) in 29 (10%). Ninety (32%) had previously failed with a PI. Proportions of people with virological success at 48/96/144 weeks were 90%/87%/88% (TLOVR) and 74%/67%/59% (snapshot analysis), respectively. The rates of VF were 8%/8%/6%. Rates of adverse events leading to study discontinuation were 0.4%/1%/2%. The multivariable adjusted analysis showed an association between VF and nadir CD4+ (hazard ratio [HR] 0.63 [95% confidence interval [CI]: 0.42-0.93] per 100 cells higher), time with pVL ≤50 copies/mL (HR 0.87 [95% CI: 0.79-0.96] per 6 months longer), and previous failure with a PI (HR 2.78 [95% CI: 1.28-6.04]). Resistance selection at failure was uncommon.A switch to ATV + ABC/3TC in selected subjects with suppressed viremia was associated with low rates of VF and discontinuation due to adverse events, even in subjects not receiving ATV/r. The strategy might be considered in those with long-term suppression and no prior PI failure.

  14. Evaluation of an air sampling technique for assessing low-level volatile organic compounds in indoor environments.

    Science.gov (United States)

    LeBouf, Ryan F; Casteel, Chris; Rossner, Alan

    2010-02-01

    Measuring trace levels of volatile organic compounds (VOCs) in indoor environments is important for the characterization of occupant exposures. The ability to quickly collect air samples at relatively low costs per sample can increase the number of samples that can be collected and thus improve the overall assessment of potential exposures. The specific goal of this paper is to evaluate the accuracy and precision of evacuated glass bottle air samplers (Entech Bottle-Vacs) to collect representative VOC samples at part-per-billion concentrations in indoor environments. Laboratory generated data are also included to validate the precision and accuracy of the method. Multiple Bottle-Vacs in 10 residences in northern New York over 18 different sampling periods were used to collect whole-air VOC samples. Percent relative standard deviations ranged from 1.2 to 20.3% with a median of 8.8% for the 21 compounds analyzed in each Bottle-Vac. Two sampling techniques were used: around the valve (ATV) and through the valve (TTV). Linear regressions of ATV and TTV sample collection into the Bottle-Vacs show that these two sampling techniques are reproducible. Paired t test results show that ATV sampling is more reproducible than TTV; ATV paired samples were statistically the same 100% of the time whereas TTV paired samples were statistically the same 76.9% of the time. ATV sampling of low-level VOCs in indoor built environments is a reproducible chemical sampling technique that could be used by building occupants as a quick and inexpensive means of area sampling.

  15. Development and Validation of Stability Indicating HPTLC and HPLC Methods for Simultaneous Determination of Telmisartan and Atorvastatin in Their Formulations

    Directory of Open Access Journals (Sweden)

    Kaliappan Ilango

    2013-01-01

    Full Text Available The present study describes development and subsequent validation of stability indicating HPLC and HPTLC methods for simultaneous estimation of Telmisartan (TLM and Atorvastatin (ATV in their combined formulation. The proposed RP-HPLC method utilizes a Phenomenex Luna C18 column using acetonitrile: 0.025 M ammonium acetate (38 : 52%, v/v as mobile phase (pH 3.8, flow rate of 1.0 mL/min. Quantification was achieved with UV detection at 281 nm over concentration range of 12 to 72 μg/mL for TLM and 3 to 18 μg/mL for ATV respectively. In HPTLC, separations were performed on silica gel 60 F254 using toluene-methanol-ethyl acetate-acetic acid (5 : 1 : 1 : 0.3, v/v as mobile phase. The compact bands of TLM and ATV at 0.37 ± 0.02 and 0.63 ± 0.01 respectively were scanned at 279 nm. Linear regression analysis revealed linearity in the range of 40 to 240 ng/band for TLM and 10 to 60 ng/band for ATV respectively. For both the methods, dosage form was exposed to thermal, photolytic, acid, alkali and oxidative stress. The methods distinctly separated the drugs and degradation products even in actual samples. In conclusion, the proposed HPLC and HPTLC methods were appropriate for routine quantification of TLM and ATV in tablet formulation.

  16. Neuromusculoskeletal disorders in the neck and upper extremities among drivers of all-terrain vehicles – a case series

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    Nilsson Tohr

    2004-01-01

    Full Text Available Abstract Background The purpose of this study was to investigate whether professional drivers of all-terrain vehicles (ATVs with neck pain have a different array of neuromusculoskeletal disorders in the neck and upper extremities than a referent group with neck pain from the general population. It is hypothesized that exposure to shock-type vibration and unfavorable working postures in ATVs have the capacity to cause peripheral nervous lesions. Methods This study was based on a case series analyzed according to a case-case comparison design. The study population consisted of 60 male subjects, including professional drivers of forest machines (n = 15, snowmobiles (n = 15, snowgroomers (n = 15 and referents from the general population (n = 15 all of whom had reported neck pain in a questionnaire and underwent an extensive physical examination of the neck and upper extremities. Based on symptom history, symptoms and signs, and in some cases chemical, electroneurographical and radiological findings, subjects were classified as having a nociceptive or neuropathic disorder or a mix of these types. Results The occurrence of asymmetrical and focal neuropathies (peripheral nervous lesion, pure or in a mix with a nociceptive disorder was common among cases in the ATV driver groups (47%–79%. This contrasted with the referents that were less often classified as having asymmetrical and focal neuropathy (27%, but instead had more nociceptive disorders. The difference was most pronounced among drivers of snowgroomers, while drivers of forest machines were more frequently classified as having a nociceptive disorder originating in the muscles. Conclusion This study found a high prevalence of assymetrical and focal neuropathies among drivers with pain in the neck, operating various ATVs. It seems as if exposure to shock-type whole-body vibration (WBV and appurtenant unfavorable postures in ATVs may be associated to peripheral nervous lesions.

  17. Off-road vehicle fatalities: A comparison of all-terrain vehicle and snowmobile accidents in Sweden

    Directory of Open Access Journals (Sweden)

    Torfinn Gustafsson

    2013-07-01

    Full Text Available This study investigates accident fatalities involving two types of off-road vehicles: snowmobiles and all-terrain vehicles (ATVs. All snowmobile fatalities in Sweden from the 2006/2007 season through the 2011/2012 season, and all ATV fatalities from 2007 through 2012, were retrospectively examined. A total of 107 fatalities—57 snowmobile-related and 50 ATV-related—were found. Most deaths occurred on weekends (71% of the snowmobile-related and 72% of the ATV-related. A majority of the fatalities were males (91% and 94%, with the largest share in the age group 40–49 years (19% and 24%. The most common causes of death were blunt trauma (56% and 66%, drowning (30% vs 6%, and traumatic asphyxia (9% vs 14%. Among victims who were tested (95% vs 92%, a very high share was found to be inebriated (59% vs 61%, and mean blood alcohol concentration was also high (1.9 vs 1.7 g/l. Forty-seven percent of snowmobile-related fatalities and 48% of ATV-related fatalities had a blood alcohol concentration above 1.0 g/l. This means that there was a very strong association between off-road vehicle fatalities and drunken riding; steps to prevent riding while intoxicated seem to be the most important preventive measure. Automatic measures such as alcolocks are probably the most effective. The obvious at-risk group to target is middle-aged men with high alcohol consumption.

  18. Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma

    Science.gov (United States)

    Blanquiceth, Yurany; Rodríguez-Perea, Ana Lucia; Tabares Guevara, Jorge H.; Correa, Luis Alfonso; Sánchez, María Dulfary; Ramírez-Pineda, José Robinson; Velilla, Paula Andrea

    2016-01-01

    Regulatory T cells (Tregs) play an important role by controlling allergic inflammation of airways. Recently, it has been shown that statins have immunomodulatory properties, probably mediated by their effects on Tregs. Therefore, we evaluated the in vivo effect of atorvastatin (ATV) on Tregs and its association with the inflammatory process in a model of allergic asthma. BALB/c mice were sensitized with ovalbumin (OVA) and then challenged with intranasal OVA. ATV (40 mg/kg) was delivered by daily intraperitoneal injection for 7 or 15 days before each OVA challenge. ATV treatment for 7 days increased the frequency of Tregs in mediastinal lymph nodes (MLN) and the interleukin (IL)-10 in lungs. After 15 days of treatment, ATV increased the percentage of glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR+) and programmed cell death protein 1 (PD-1+) Tregs in the lung, without enhancing their suppressive activity, but also increased the percentage of conventional T cells expressing GITR+, PD1+, and OX-40 (tumor necrosis factor receptor superfamily member 4). Although no significant changes were observed in the number of inflammatory cells in the bronchoalveolar lavage (BAL), OVA-specific immunoglobulin E in the serum, and type 2 helper (Th2) cytokines in the lungs, there was a significant decrease of peribronchial inflammation that negatively correlated with the Tregs in MLN and the concentration of IL-10 in the lung. These results suggest that ATV has an immunomodulatory role possibly mediated by their effects on Tregs, which could contribute to the control of inflammation during allergic asthma. Further studies are necessary to elucidate the contribution of Treg to immunomodulatory action of statins in the context of allergic asthma. PMID:28066430

  19. SU-E-J-272: Auto-Segmentation of Regions with Differentiating CT Numbers for Treatment Response Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Yang, C; Noid, G; Dalah, E; Paulson, E; Li, X [Medical College of Wisconsin, Milwaukee, WI (United States); Gilat-Schmidt, T [Marquette University, Milwaukee, WI (United States)

    2015-06-15

    Purpose: It has been reported recently that the change of CT number (CTN) during and after radiation therapy (RT) may be used to assess RT response. The purpose of this work is to develop a tool to automatically segment the regions with differentiating CTN and/or with change of CTN in a series of CTs. Methods: A software tool was developed to identify regions with differentiating CTN using K-mean Cluster of CT numbers and to automatically delineate these regions using convex hull enclosing method. Pre- and Post-RT CT, PET, or MRI images acquired for sample lung and pancreatic cancer cases were used to test the software tool. K-mean cluster of CT numbers within the gross tumor volumes (GTVs) delineated based on PET SUV (standard uptake value of fludeoxyglucose) and/or MRI ADC (apparent diffusion coefficient) map was analyzed. The cluster centers with higher value were considered as active tumor volumes (ATV). The convex hull contours enclosing preset clusters were used to delineate these ATVs with color washed displays. The CTN defined ATVs were compared with the SUV- or ADC-defined ATVs. Results: CTN stability of the CT scanner used to acquire the CTs in this work is less than 1.5 Hounsfield Unit (HU) variation annually. K-mean cluster centers in the GTV have difference of ∼20 HU, much larger than variation due to CTN stability, for the lung cancer cases studied. The dice coefficient between the ATVs delineated based on convex hull enclosure of high CTN centers and the PET defined GTVs based on SUV cutoff value of 2.5 was 90(±5)%. Conclusion: A software tool was developed using K-mean cluster and convex hull contour to automatically segment high CTN regions which may not be identifiable using a simple threshold method. These CTN regions were reasonably overlapped with the PET or MRI defined GTVs.

  20. 盐酸吡格列酮和阿托伐他汀钙的体外代谢相互作用研究%Metabolic interactions between Pioglitazone hydrochloride and Atorvastatin calcium in rat liver microsomes

    Institute of Scientific and Technical Information of China (English)

    陈和莉; 杨付英; 张文萍; 杨文成; 付岩; 党宏万

    2013-01-01

    OBJECTIVE To establish an HPLC method for determination of Pioglitazone hydrochloride( Pio) and Atorvastatin calcium ( Atv) , and to investigate the interactions between Pio and Atv in rat liver microsomes. METHODS A calcium precipitation method was utilized to prepare rat liver microsomes ( RLM). The HPLC method with Hydro - RP 80A - C18 column and a mobile phase made up of acetonitrile - water( including 3 mL·L-1 glacial acetic acid and 1 mL·L-1 triethylamine, 25% ammonia to adjust pH to 5. 15) (55 : 45) , a flow rate at 1. 0 mL · min-1 and the detection wavelength at 240 nm for Pio, 246 nm for Atv, a column temperature at 25 ℃ , was established for the determination of Pio and Atv. The metabolism - time profiles were constructed after incubation under certain conditions, and the metabolic percentage of concurrent Pio and Atv was compared with that of Pio or Atv alone. RESULTS The calibration curves of Pio and Atv were linear in the range of 5 - 240 μmol · L-1 ( r = 0. 9995 ) and 1-150 μmol · L-1 ( r = 0. 9997 ) , respectively. The intra - day and inter - day RSD of Pio were less than 3.79% and 3. 20% , while those of Atv were less than 4.07% and 5. 25% . The extraction recoveries of Pio in low,middle,high concentrations were 104. 64% ,108. 20% ,91. 15% , while those of Atv were 100.74% , 107.45% , 105.27%. When the RLM protein concentration was diluted to 0. 5 mg·mL-1 ,Pio or Atv alone was eliminated about 42. 37% or 26. 32% after incubation for 60 min,the depletion percentage of concurrent Pio and Atv after incubation reduced to 27. 57% and 8. 96% ,espectively. CONCLUSION The method was sensitive and accurate,and can be used to study the metabolism of Pio and Atv in vitro. Concurrent Pio and Atv after incubation appeared to significantly lower metabolism compared with Pio and Atv.%目的 采用HPLC法测定体外盐酸吡格列酮(Pio)、阿托伐他汀钙(Atv),并研究PIO和Atv在大鼠肝微粒体(RLM)中的代谢相互作用.方法 用钙

  1. Comparison of the HadGEM2 climate-chemistry model against in situ and SCIAMACHY atmospheric methane data

    Directory of Open Access Journals (Sweden)

    G. D. Hayman

    2014-12-01

    Full Text Available Wetlands are a major emission source of methane (CH4 globally. In this study, we evaluate wetland emission estimates derived using the UK community land surface model (JULES, the Joint UK Land Earth Simulator against atmospheric observations of methane, including, for the first time, total methane columns derived from the SCIAMACHY instrument on board the ENVISAT satellite. Two JULES wetland emission estimates are investigated: (a from an offline run driven with Climatic Research Unit–National Centers for Environmental Prediction (CRU-NCEP meteorological data and (b from the same offline run in which the modelled wetland fractions are replaced with those derived from the Global Inundation Extent from Multi-Satellites (GIEMS remote sensing product. The mean annual emission assumed for each inventory (181 Tg CH4 per annum over the period 1999–2007 is in line with other recently published estimates. There are regional differences as the unconstrained JULES inventory gives significantly higher emissions in the Amazon (by ~36 Tg CH4 yr−1 and lower emissions in other regions (by up to 10 Tg CH4 yr−1 compared to the JULES estimates constrained with the GIEMS product. Using the UK Hadley Centre's Earth System model with atmospheric chemistry (HadGEM2, we evaluate these JULES wetland emissions against atmospheric observations of methane. We obtain improved agreement with the surface concentration measurements, especially at high northern latitudes, compared to previous HadGEM2 runs using the wetland emission data set of Fung et al. (1991. Although the modelled monthly atmospheric methane columns reproduce the large-scale patterns in the SCIAMACHY observations, they are biased low by 50 part per billion by volume (ppb. Replacing the HadGEM2 modelled concentrations above 300 hPa with HALOE–ACE assimilated TOMCAT output results in a significantly better agreement with the SCIAMACHY observations. The use of the GIEMS product to constrain the JULES

  2. Comparison of the HadGEM2 climate-chemistry model against in-situ and SCIAMACHY atmospheric methane data

    Directory of Open Access Journals (Sweden)

    G. D. Hayman

    2014-05-01

    Full Text Available Wetlands are a major emission source of methane (CH4 globally. In this study, we have evaluated wetland emission estimates derived using the UK community land surface model (JULES, the Joint UK Land Earth Simulator against atmospheric observations of methane, including, for the first time, total methane columns derived from the SCIAMACHY instrument on board the ENVISAT satellite. Two JULES wetland emission estimates were investigated: (a from an offline run driven with CRU-NCEP meteorological data and (b from the same offline run in which the modelled wetland fractions were replaced with those derived from the Global Inundation Extent from Multi-Satellites (GIEMS remote sensing product. The mean annual emission assumed for each inventory (181 Tg CH4 per annum over the period 1999–2007 is in line with other recently-published estimates. There are regional differences as the unconstrained JULES inventory gave significantly higher emissions in the Amazon and lower emissions in other regions compared to the JULES estimates constrained with the GIEMS product. Using the UK Hadley Centre's Earth System model with atmospheric chemistry (HadGEM2, we have evaluated these JULES wetland emissions against atmospheric observations of methane. We obtained improved agreement with the surface concentration measurements, especially at northern high latitudes, compared to previous HadGEM2 runs using the wetland emission dataset of Fung (1991. Although the modelled monthly atmospheric methane columns reproduced the large–scale patterns in the SCIAMACHY observations, they were biased low by 50 part per billion by volume (ppb. Replacing the HadGEM2 modelled concentrations above 300 hPa with HALOE–ACE assimilated TOMCAT output resulted in a significantly better agreement with the SCIAMACHY observations. The use of the GIEMS product to constrain JULES-derived wetland fraction improved the description of the wetland emissions in JULES and gave a good description

  3. Comparison of the HadGEM2 climate-chemistry model against in situ and SCIAMACHY atmospheric methane data

    Science.gov (United States)

    Hayman, G. D.; O'Connor, F. M.; Dalvi, M.; Clark, D. B.; Gedney, N.; Huntingford, C.; Prigent, C.; Buchwitz, M.; Schneising, O.; Burrows, J. P.; Wilson, C.; Richards, N.; Chipperfield, M.

    2014-12-01

    Wetlands are a major emission source of methane (CH4) globally. In this study, we evaluate wetland emission estimates derived using the UK community land surface model (JULES, the Joint UK Land Earth Simulator) against atmospheric observations of methane, including, for the first time, total methane columns derived from the SCIAMACHY instrument on board the ENVISAT satellite. Two JULES wetland emission estimates are investigated: (a) from an offline run driven with Climatic Research Unit-National Centers for Environmental Prediction (CRU-NCEP) meteorological data and (b) from the same offline run in which the modelled wetland fractions are replaced with those derived from the Global Inundation Extent from Multi-Satellites (GIEMS) remote sensing product. The mean annual emission assumed for each inventory (181 Tg CH4 per annum over the period 1999-2007) is in line with other recently published estimates. There are regional differences as the unconstrained JULES inventory gives significantly higher emissions in the Amazon (by ~36 Tg CH4 yr-1) and lower emissions in other regions (by up to 10 Tg CH4 yr-1) compared to the JULES estimates constrained with the GIEMS product. Using the UK Hadley Centre's Earth System model with atmospheric chemistry (HadGEM2), we evaluate these JULES wetland emissions against atmospheric observations of methane. We obtain improved agreement with the surface concentration measurements, especially at high northern latitudes, compared to previous HadGEM2 runs using the wetland emission data set of Fung et al. (1991). Although the modelled monthly atmospheric methane columns reproduce the large-scale patterns in the SCIAMACHY observations, they are biased low by 50 part per billion by volume (ppb). Replacing the HadGEM2 modelled concentrations above 300 hPa with HALOE-ACE assimilated TOMCAT output results in a significantly better agreement with the SCIAMACHY observations. The use of the GIEMS product to constrain the JULES-derived wetland

  4. Integrating hydrology within a fully coupled environmental prediction system

    Science.gov (United States)

    Best, Martin; Lewis, Huw; Ashton, Heather; Blyth, Eleanor; Martinez, Alberto

    2017-04-01

    Historically the hydrological community and the community developing the land surface component of atmospheric models have both been tasked with representing the terrestrial hydrological cycle, but have focused on different ends, namely streamflow and evaporation respectively. To date the lack of computational resources and representative observations have limited the integration of the skills within these two communities. However, this is no longer the case. In addition, the drive toward fully integrated high resolution environmental prediction systems, coupling atmosphere, land and ocean on regional domains, requires an accurate representation for all aspects of terrestrial hydrology. Hence a new focus is emerging to integrate improved hydrological processes within the land surface components of atmospheric models. The UK Environmental Prediction (UKEP) project is a research experiment aimed at understanding the potential benefits for detailed environmental forecasting from a fully coupled atmosphere/land/ocean system at km-scale resolution for the UK. The prototype model utilises the Joint UK Land Environment Simulator (JULES) as its land surface component, coupled to the RFM river flow model. Although JULES has been previously used for climate studies that close the global water cycle, the JULES/RFM system has not been comprehensively evaluated for its ability to simulate river discharge. In this study we attempt some initial evaluation of the JULES/RFM system for all aspects of the terrestrial hydrological cycle, including evaporation, soil moisture and streamflow. In addition, comparisons are made between the results from the fully coupled environmental prediction system and stand alone JULES/RFM simulations forced by atmospheric driving data from the UK weather forecasting model. This provides an opportunity to assess the impact of fully coupled versus a one way coupled response for terrestrial hydrology. Finally we consider the potential for coupling JULES

  5. No difference in persistence to treatment with atazanavir or darunavir in HIV patients in a real-world setting

    Directory of Open Access Journals (Sweden)

    Amanda M Farr

    2014-11-01

    Full Text Available Introduction: There is a lack of data comparing the protease inhibitors (PIs atazanavir (ATV and darunavir (DRV in a real-world setting. This study compared persistence (time to switch/discontinuation to therapy between ATV-treated and DRV-treated patients with human immunodeficiency virus (HIV. Materials and Methods: Retrospective, observational cohort study using US insurance claims for commercially and Medicaid-insured patients. Patients were aged ≥18 years and initiated an ATV- or DRV-based regimen boosted with ritonavir between 7/1/2006 and 3/31/2013, with ≥6 months of continuous enrolment prior to and ≥3 months of continuous enrolment following initiation; patients were required to have ≥1 inpatient or outpatient medical claim with an ICD-9-CM diagnosis code for HIV during that time period of enrolment. Patients with no claims for antiretroviral therapy (ART any time prior to initiation were considered to be ART-naïve. Time to switch/discontinuation was defined as the number of days from initiation of the regimen until earliest of: (1 a ≥30-day continuous gap in therapy in ATV or DRV; (2 a prescription claim for an ART agent that was not part of the initial regimen (with the exception of changes in concomitant nucleoside reverse transcriptase inhibitors or the addition of integrase inhibitors; (3 censoring at a ≥30-day continuous gap in therapy in ritonavir; (4 censoring at disenrolment from insurance benefits or (5 censoring at the study end date (9/30/2013 in the commercial data and 12/31/2013 in the Medicaid data. Time to switch/discontinuation was compared using incidence rates and multivariable Cox proportional hazards models adjusted for calendar time, patient demographics and clinical characteristics. Results: Table 1 displays the study results and cohort sample sizes. Mean ages across the cohorts were 41–42 years. The proportions of patients who were ART-naïve were 58–59% among the ATV/r cohorts and 53–55% among

  6. 《低俗小说》

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    最经典的场景、最生动的对白、最地道的表达,尽在“影视对白”。跟着明星学英语,let’s go!本期影片:《低俗小说》。 Pulp Fiction (1994) is an American film directed by Quentin Tarantino. It stars John Travolta, Samuel Jackson, Uma Thurman and Bruce Willis. The film tells three separate (but loosely connected) stories which are set in the criminal underworld of Los Angeles. One of these stories follows Vincent Vega (Travolta) and Jules Winnfield (Jackson), two hit men for a powerful LA gangster. In this scene, Vincent and Jules are discussing Vincent' s recent trip to Europe.

  7. El Bovarysmo // The Bovarysm

    Directory of Open Access Journals (Sweden)

    Mario Elkin Ramírez

    2011-12-01

    Full Text Available Luego de un breve recorrido por una sucinta historia del amor, se encuentra el lugar revolucionario que la obra de Gustave Flaubert constituyó como nuevo paradigma del amor y de la feminidad. Se retoman a continuación las formulaciones de Jules de Gaultier, quien introdujo el término de Bovarysmo en la psiquiatría, para, finalmente, mostrar el destino de esa noción en el psicoanálisis lacaniano. // After a short pass through a brief love story, Gustave Flaubert work that constituted a new love and femininity paradigm found a revolutionary place. Jules de Gaultier formulations where the Bovarysme term was introduced in psychiatry are restudy to show this notion destiny in the Lacanian psychoanalysis.

  8. Impact of land cover changes on the South African climate

    Energy Technology Data Exchange (ETDEWEB)

    Ngwana, T I [South African Weather Service, Pretoria (South Africa); Demory, M-E; Vidale, P L; Plant, R S [University of Reading, Earley Gate, Reading (United Kingdom); Mbedzi, M P, E-mail: isaac.ngwana@weathersa.co.z [Eskom Holdings, Cleveland (South Africa)

    2010-08-15

    The Joint UK Land Environmental Simulator (JULES) was run offline to investigate the sensitivity of land surface type changes over South Africa. Sensitivity tests were made in idealised experiments where the actual land surface cover is replaced by a single homogeneous surface type. The vegetation surface types on which some of the experiments were made are static. Experimental tests were evaluated against the control. The model results show among others that the change of the surface cover results in changes of other variables such as soil moisture, albedo, net radiation and etc. These changes are also visible in the spin up process. The model shows different surfaces spinning up at different cycles. Because JULES is the land surface model of Unified Model, the results could be more physically meaningful if it is coupled to the Unified Model.

  9. Contribuições da psiquiatria clássica ao diagnóstico da melancolia: o delírio de negação e o delírio de indignidade

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Ferreira

    2008-09-01

    Full Text Available Discute-se a respeito da importância que teve a pesquisa empreendida pelos psiquiatras franceses Jules Cotard e Jules Séglas nas primeiras elaborações freudianas acerca da melancolia. No esforço feito por Freud em distinguir as afecções psíquicas, ele leva em consideração os principais conceitos destacados pela psiquiatria clássica: a dor moral, condição para o delírio de indignidade, o mecanismo de auto-acusação e a hemorragia de libido. Busca-se uma articulação entre esses autores. Neste artigo essa retomada é importante para um aprimoramento no diagnóstico da melancolia. Constata-se que a melancolia na contemporaneidade nos remete não somente aos clássicos, mas sobretudo a Freud, em seus primeiros rascunhos.

  10. Revising Hydrology of a Land Surface Model

    Science.gov (United States)

    Le Vine, Nataliya; Butler, Adrian; McIntyre, Neil; Jackson, Christopher

    2015-04-01

    Land Surface Models (LSMs) are key elements in guiding adaptation to the changing water cycle and the starting points to develop a global hyper-resolution model of the terrestrial water, energy and biogeochemical cycles. However, before this potential is realised, there are some fundamental limitations of LSMs related to how meaningfully hydrological fluxes and stores are represented. An important limitation is the simplistic or non-existent representation of the deep subsurface in LSMs; and another is the lack of connection of LSM parameterisations to relevant hydrological information. In this context, the paper uses a case study of the JULES (Joint UK Land Environmental Simulator) LSM applied to the Kennet region in Southern England. The paper explores the assumptions behind JULES hydrology, adapts the model structure and optimises the coupling with the ZOOMQ3D regional groundwater model. The analysis illustrates how three types of information can be used to improve the model's hydrology: a) observations, b) regionalized information, and c) information from an independent physics-based model. It is found that: 1) coupling to the groundwater model allows realistic simulation of streamflows; 2) a simple dynamic lower boundary improves upon JULES' stationary unit gradient condition; 3) a 1D vertical flow in the unsaturated zone is sufficient; however there is benefit in introducing a simple dual soil moisture retention curve; 4) regionalized information can be used to describe soil spatial heterogeneity. It is concluded that relatively simple refinements to the hydrology of JULES and its parameterisation method can provide a substantial step forward in realising its potential as a high-resolution multi-purpose model.

  11. The research reactors their contribution to the reactors physics; Les reacteurs de recherche leur apport sur la physique des reacteurs

    Energy Technology Data Exchange (ETDEWEB)

    Barral, J.C. [Electricite de France (EDF), 75 - Paris (France); Zaetta, A. [CEA/Cadarache, Direction des Reacteurs Nucleaires, DRN, 13 - Saint-Paul-lez-Durance (France); Johner, J. [CEA/Cadarache, Dept. de Recherches sur la Fusion Controlee (DRFC), 13 - Saint Paul lez Durance (France); Mathoniere, G. [CEA/Saclay, DEN, 91 - Gif sur Yvette (France)] [and others

    2000-07-01

    The 19 october 2000, the french society of nuclear energy organized a day on the research reactors. This associated report of the technical session, reactors physics, is presented in two parts. The first part deals with the annual meeting and groups general papers on the pressurized water reactors, the fast neutrons reactors and the fusion reactors industry. The second part presents more technical papers about the research programs, critical models, irradiation reactors (OSIRIS and Jules Horowitz) and computing tools. (A.L.B.)

  12. The Nobel Prize laureate - father of anaphylaxis Charles-Robert Richet (1850-1935) and his anticancerous serum.

    Science.gov (United States)

    Androutsos, G; Karamanou, M; Stamboulis, E; Liappas, I; Lykouras, E; Papadimitriou, G N

    2011-01-01

    Professor of physiology Charles-Robert Richet, winner of the Nobel Prize in 1913, is best known for his work on anaphylaxis. However, with his collaborator Jules Héricourt studied the effects of antibody treatment and made the very first attempts to fight cancer with serotherapy. Being versatile, Richet contributed in neurology, psychology and was also a poet, playwrighter, pacifist and pioneer in aviation.

  13. La survivance de Michelet : Historiographie et politique en France depuis 1870

    NARCIS (Netherlands)

    Creyghton, C.M.H.G.

    2016-01-01

    Après sa mort, l’historien Jules Michelet (1798-1874) a été érigé en historien national canonique dans la mémoire collective française. En même temps qu’il est devenu un auteur classique pour les historiens, il est invoqué et célébré aussi dans le domaine politique. La commémoration nationale de son

  14. The fabulous legacy of a Nobel Prize Laureate: Ralph M. Steinman, 1943-2011

    OpenAIRE

    Zitvogel, Laurence; Merad, Miriam; Kroemer, Guido

    2012-01-01

    The Nobel Prize in Physiology or Medecine 2011 was awarded to Ralph M. Steinman, Jules A. Hoffman and Bruce A. Beutler for the discovery of essential elements of innate immunity, in particular dendritic cells (DCs) and toll-like receptors (TLRs). Antigens become immunogenic and capable of triggering an adaptive immune response involving antigen-specific, MHC- restricted effector T cells, only if they are captured and presented by “accessory” cells. In 1972, Ralph M. Steinman and Zanvil Cohn i...

  15. The quality of life impact of peripheral versus central vision loss with a focus on glaucoma versus age-related macular degeneration

    OpenAIRE

    Evans, Keith; Law, Simon; Walt, John; Buchholz, Patricia; Hansen,

    2009-01-01

    Keith Evans1, Simon K Law2, John Walt3, Patricia Buchholz4, Jan Hansen31Global Health Outcomes, Wolters Kluwer Health, Chester, United Kingdom; 2Jules Stein Eye Institute, Los Angeles, CA, USA; 3Global Health Outcomes Strategy and Research, Allergan Inc., Irvine, CA, USA; 4Health Economics, Pricing, and Reimbursement, Allergan GmbH, Ettlingen, GermanyPurpose: It is well accepted that conditions that cause central vision loss (CVL) have a negative impact on functional ability and quality of li...

  16. An operational framework for equity in the 2015 agreement

    CSIR Research Space (South Africa)

    Ngwadla, Xolisa

    2014-01-01

    Full Text Available /entries/justice- distributive/>. Coleman, Jules and Mendlow, Gabriel, "Theories of Tort Law", The Stanford Encyclopedia of Philosophy (Fall 2010 Edition), Edward N. Zalta (ed.), URL =

  17. Viis värvikat visiooni / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2009-01-01

    Eesti Kunstiakadeema lõputööde näitus "Tase'09" Rüütelkonna hoones Toompeal 21. juunini. Arhitekt Martin Voltri Tartu linnujaama projektist. Madis Nurmsi lavakujundusest ja -kostüümidest Jules Massenet' ooperile "Thais", mis esietendus 22. mail Pärnu Endlas. Klaasikunstnik Merle Bukoveci sisepurskkaevude seeriast "Voolujooned". Tootedisainer Pent Talveti magistritööst. Uku-Kristjan Küttise tehtud kirjatüübist

  18. Comparison of oxidative stress markers in HIV-infected patients on efavirenz or atazanavir/ritonavir-based therapy

    Directory of Open Access Journals (Sweden)

    Vicente Estrada

    2014-11-01

    Full Text Available Introduction: Chronic low-grade inflammation and immune activation may persist in HIV patients despite effective antiretroviral therapy (ART. These abnormalities are associated with increased oxidative stress (OS. Bilirubin (BR may have a beneficial role in counteracting OS. Atazanavir (ATV inhibits UGT1A1, thus increasing unconjugated BR levels, a distinctive feature of this drug. We compared changes in OS markers in HIV patients on ATV/r versus efavirenz (EFV-based first-line therapies. Materials and Methods: Cohort of the Spanish Research Network (CoRIS is a multicentre, open, prospective cohort of HIV-infected patients naïve to ART at entry and linked to a biobank. We identified hepatitis C virus/hepatitis B virus (HCV/HBV negative patients who started first-line ART with either ATV/r or EFV, had a baseline biobank sample and a follow-up sample after at least nine months of ART while maintaining initial regimen and being virologically suppressed. Lipoprotein-associated Phospholipase A2 (Lp-PLA2, Myeloperoxidase (MPO and Oxidized LDL (OxLDL were measured in paired samples. Marker values at one year were interpolated from available data. Multiple imputations using chained equations were used to deal with missing values. Change in the OS markers was modelled using multiple linear regressions adjusting for baseline marker values and baseline confounders. Correlations between continuous variables were explored using Pearson's correlation tests. Results: 145 patients (97 EFV; 48 ATV/r were studied. Mean (SD baseline values for OS markers in EFV and ATV/r groups were: Lp-PLA2 [142.2 (72.8 and 150.1 (92.8 ng/mL], MPO [74.3 (48.2 and 93.9 (64.3 µg/L] and OxLDL [76.3 (52.3 and 82.2 (54.4 µg/L]. After adjustment for baseline variables patients on ATV/r had a significant decrease in Lp-PLA2 (estimated difference −16.3 [CI 95%: −31.4, −1.25; p=0.03] and a significantly lower increase in OxLDL (estimated difference −21.8 [−38.0, −5.6; p<0

  19. Three different methods for determination of binary mixture of Amlodipine and Atorvastatin using dual wavelength spectrophotometry

    Science.gov (United States)

    Darwish, Hany W.; Hassan, Said A.; Salem, Maissa Y.; El-Zeany, Badr A.

    2013-03-01

    Three simple, specific, accurate and precise spectrophotometric methods depending on the proper selection of two wavelengths are developed for the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium (ATV) in tablet dosage forms. The first method is the new Ratio Difference method, the second method is the Bivariate method and the third one is the Absorbance Ratio method. The calibration curve is linear over the concentration range of 4-40 and 8-32 μg/mL for AML and ATV, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Methods are validated according to the ICH guidelines and accuracy, precision, repeatability and robustness are found to be within the acceptable limit. The mathematical explanation of the procedures is illustrated.

  20. Possibilities and barriers for e-learning in primary school in Denmark

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Rootzén, Helle

    How much are we using e-learning in primary school in Denmark? What are the barriers? What are the benefits? Why do we not use e-learning even more? These questions have been the focus for a one year national investigation conducted by ATV, The Danish Academy of Technical Sciences. The investigat......How much are we using e-learning in primary school in Denmark? What are the barriers? What are the benefits? Why do we not use e-learning even more? These questions have been the focus for a one year national investigation conducted by ATV, The Danish Academy of Technical Sciences...... to gather evidence in learning, and higher demands for evidence for e-learning tools than for other educational tools. There is also a missing trust and missing communication among stakeholders. We also observed a lack of vision on how digitalization can go beyond "PDFing" a book, and, finally, we met...

  1. Possibilities and barriers for e-learning in primary school in Denmark

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Rootzen, Helle

    2016-01-01

    How much are we using e-learning in primary school in Denmark? What are the barriers? What are the benefits? Why do we not use e-learning even more? These questions have been the focus for a one year national investigation conducted by ATV, The Danish Academy of Technical Sciences. The investigat......How much are we using e-learning in primary school in Denmark? What are the barriers? What are the benefits? Why do we not use e-learning even more? These questions have been the focus for a one year national investigation conducted by ATV, The Danish Academy of Technical Sciences...... to gather evidence in learning, and higher demands for evidence for e-learning tools than for other educational tools. There is also a missing trust and missing communication among stakeholders. We also observed a lack of vision on how digitalization can go beyond "PDFing" a book, and, finally, we met...

  2. Theoretical studies of interaction models of human acetylcholine esterase with different inhibitors

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Alzheimer’s disease(AD) is a progressive neurodegenerative disorder and one of the most common causes of dementia in the elderly.Acetylcholine esterase inhibitors(AChEI) are the main drugs used in the treatment of AD.In this work,docking studies have been performed in order to understand the interaction between a number of inhibitors(tacrine,rivastigmine,huperzine A,TV-3326(ladostigil),donepezil and anseculin) and acetylcholine esterase(AChE).The calculated binding affinities between inhibitors and AChE increase in the order tacrineA-3326

  3. Three different methods for determination of binary mixture of Amlodipine and Atorvastatin using dual wavelength spectrophotometry.

    Science.gov (United States)

    Darwish, Hany W; Hassan, Said A; Salem, Maissa Y; El-Zeany, Badr A

    2013-03-01

    Three simple, specific, accurate and precise spectrophotometric methods depending on the proper selection of two wavelengths are developed for the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium (ATV) in tablet dosage forms. The first method is the new Ratio Difference method, the second method is the Bivariate method and the third one is the Absorbance Ratio method. The calibration curve is linear over the concentration range of 4-40 and 8-32 μg/mL for AML and ATV, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Methods are validated according to the ICH guidelines and accuracy, precision, repeatability and robustness are found to be within the acceptable limit. The mathematical explanation of the procedures is illustrated.

  4. Online measuring devices at sewage treatment plants - state of the art and future market potential; On-Line-Messtechnik auf Klaeranlagen - Aktueller Stand und Marktpotential fuer die Zukunft

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, P. [Inst. fuer Siedlungswasserbau, Wasserguete- und Abfallwirtschaft der Univ. Stuttgart, Abt. Abwassertechnik (Germany); Schlegel, S. [Emschergenossenschaft, Essen (Germany)

    1997-12-31

    By means of a survey commissioned by ATV/GFA, the purposes of use and spheres of use as well as the operating experience with online measuring devices for the determination of ammonium, oxidized nitrogen compounds and orthophosphate were established and evaluated. In addition, data were acquired with the aid of other units for the continuous recording of chemical and physical parameters of sewage treatment. Finally, the future market potentials and development pospects of online measuring devices were evaluated. (orig.) [Deutsch] Anhand einer im Auftrag der ATV/GFA durchgefuehrten Umfrage wurden Einsatzzweck, Einsatzbereiche und Betriebserfahrungen von On-line-Messgeraeten zur Bestimmung von Ammonium, oxidierten Stickstoffverbindungen und Orthophosphat dargestellt und bewertet. Zusaetzlich wurden auch Daten von anderen Geraeteeinheiten zur kontinuierlichen Erfassung von chemischen und physikalischen Parametern bei der Abwasserreinigung erhoben. Anschliessend wurde das zukuenftige Marktpotential und die Entwicklungsmoeglichkeiten bei der On-line-Messtechnik bewertet. (orig.)

  5. Advanced stability indicating chemometric methods for quantitation of amlodipine and atorvastatin in their quinary mixture with acidic degradation products

    Science.gov (United States)

    Darwish, Hany W.; Hassan, Said A.; Salem, Maissa Y.; El-Zeany, Badr A.

    2016-02-01

    Two advanced, accurate and precise chemometric methods are developed for the simultaneous determination of amlodipine besylate (AML) and atorvastatin calcium (ATV) in the presence of their acidic degradation products in tablet dosage forms. The first method was Partial Least Squares (PLS-1) and the second was Artificial Neural Networks (ANN). PLS was compared to ANN models with and without variable selection procedure (genetic algorithm (GA)). For proper analysis, a 5-factor 5-level experimental design was established resulting in 25 mixtures containing different ratios of the interfering species. Fifteen mixtures were used as calibration set and the other ten mixtures were used as validation set to validate the prediction ability of the suggested models. The proposed methods were successfully applied to the analysis of pharmaceutical tablets containing AML and ATV. The methods indicated the ability of the mentioned models to solve the highly overlapped spectra of the quinary mixture, yet using inexpensive and easy to handle instruments like the UV-VIS spectrophotometer.

  6. Physiological demands of off-road vehicle riding.

    Science.gov (United States)

    Burr, Jamie F; Jamnik, Veronica K; Shaw, Jim A; Gledhill, Norman

    2010-07-01

    The purpose of this study was to characterize the physiological demands of recreational off-road vehicle riding under typical riding conditions using habitual recreational off-road vehicle riders (n = 128). Comparisons of the physical demands of off-road vehicle riding were made between vehicle types (all-terrain vehicle (ATV) and off-road motorcycle (ORM)) to the demands of common recreational activities. Habitual riders (ATV = 56, ORM = 72) performed strength assessments before and after a representative trail ride (48 +/- 24.2 min), and ambulatory oxygen consumption was measured during one lap (24.2 +/- 11.8 min) of the ride. The mean VO2 requirement (mL x kg(-1) x min(-1)) while riding an off-road vehicle was 12.1 +/- 4.9 for ATV and 21.3 +/- 7.1 for ORM (P = 0.002), which is comparable to the VO2 required of many common recreational activities. Temporal analysis of activity intensity revealed approximately 14% of an ATV ride and 38% of an ORM ride are within the intensity range (940% VO2 reserve) required to achieve changes in aerobic fitness. Riding on a representative course also led to muscular fatigue, particularly in the upper body. On the basis of the measured metabolic demands, evidence of muscular strength requirements, and the associated caloric expenditures with off-road vehicle riding, this alternative form of activity conforms to the recommended physical activity guidelines and can be effective for achieving beneficial changes in health and fitness.

  7. A randomized, controlled trial of initial anti-retroviral therapy with abacavir/lamivudine/zidovudine twice-daily compared to atazanavir once-daily with lamivudine/zidovudine twice-daily in HIV-infected patients over 48 weeks (ESS100327, the ACTION Study

    Directory of Open Access Journals (Sweden)

    McClernon Daniel

    2009-04-01

    Full Text Available Abstract Background Traditional first line regimens containing a non-nucleoside reverse transcriptase inhibitor or protease inhibitor may not be suitable for a subset of antiretroviral-naïve patients such as those with certain co-morbidities, women of child-bearing potential, and intolerability to components of standard first line therapy. This study was conducted to determine if alternate treatment options may meet the needs of both general and special patient populations. The ACTION study was a randomized, open-label, multicenter, 48-week trial that compared the safety and efficacy of a triple nucleoside regimen versus a protease inhibitor plus a dual nucleoside regimen in HIV-1 treatment-naïve subjects. Results 279 HIV-infected subjects with HIV-1 RNA (VL >5000 but 3 were randomized (1:1 to receive abacavir sulfate/lamivudine/zidovudine (ABC/3TC/ZDV twice-daily or atazanavir (ATV once-daily plus lamivudine/zidovudine (3TC/ZDV twice-daily. Protocol-defined virologic failure was based on multiple failure criteria. Non-inferiority of ABC/3TC/ZDV to ATV+3TC/ZDV was established with 62% vs. 59% of subjects achieving a VL Conclusion ABC/3TC/ZDV demonstrated comparable virologic efficacy to ATV+3TC/ZDV in this population over 48 weeks. In those with a baseline VL ≥ 100,000 c/mL, subjects in the ATV+3TC/ZDV showed better virologic efficacy. Both regimens offer benefits in select therapy-naïve subjects. Trial Registration [Clinical Trials Identifier, NCT00082394].

  8. Next Generation of Launcher & Space Vehicles Batteries

    Science.gov (United States)

    Laroye, J. F.; Brochard, P.; Grassien, J.-Y.; Masgrangeas, D.

    2008-09-01

    This paper presents several examples of Saft lithium batteries in use onboard launchers & space vehicles: ATV primary lithium manganese dioxide (LiMnO2) batteries and Rosetta primary lithium thionyl chloride (LiSOCl2) batteries as well as the VEGA rechargeable lithium-ion (Li-ion) avionics & thrust vector control (TVC) batteries.It gives an overview of possible chemistries and tradeoff to address these needs.

  9. Utilization of ADAMS to Predict Tracked Vehicle Performance%ADAMS分析软件在履带式车辆性能预测中的应用

    Institute of Scientific and Technical Information of China (English)

    聂崇训

    2003-01-01

    介绍商品模拟程序ADAMS(机械系统自动动态分析)在履带式车辆模拟中的应用.详细讨论其附加工具包ATV(ADAMS履带式车辆)在建立、维护和模拟履带式车辆模型中的功能.

  10. Interaction of Disulfiram with Antiretroviral Medications: Efavirenz Increases While Atazanavir Decreases Disulfiram Effect on Enzymes of Alcohol Metabolism

    Science.gov (United States)

    McCance-Katz, Elinore F; Gruber, Valerie A; Beatty, George; Lum, Paula; Ma, Qing; DiFrancesco, Robin; Hochreiter, Jill; Wallace, Paul K; Faiman, Morris D; Morse, Gene D

    2013-01-01

    Background and Objectives Alcohol abuse complicates treatment of HIV disease and is linked to poor outcomes. Alcohol pharmacotherapies, including disulfiram (DIS), are infrequently utilized in co-occurring HIV and alcohol use disorders possibly related to concerns about drug interactions between antiretroviral (ARV) medications and DIS. Method This pharmacokinetics study (n=40) examined the effect of DIS on efavirenz (EFV), ritonavir (RTV), or atazanavir (ATV) and the effect of these ARV medications on DIS metabolism and aldehyde dehydrogenase (ALDH) activity which mediates the DIS-alcohol reaction. Results EFV administration was associated with decreased S-Methyl-N-N-diethylthiocarbamate (DIS carbamate), a metabolite of DIS (p=0.001) and a precursor to the metabolite responsible for ALDH inhibition, S-methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO). EFV was associated with increased DIS inhibition of ALDH activity relative to DIS alone administration possibly as a result of EFV-associated induction of CYP 3A4 which metabolizes the carbamate to DETC-MeSO (which inhibits ALDH). Conversely, ATV co-administration reduced the effect of DIS on ALDH activity possibly as a result of ATV inhibition of CYP 3A4. DIS administration had no significant effect on any ARV studied. Discussion/Conclusions ATV may render DIS ineffective in treatment of alcoholism. Future Directions DIS is infrequently utilized in HIV-infected individuals due to concerns about adverse interactions and side effects. Findings from this study indicate that, with ongoing clinical monitoring, DIS should be reconsidered given its potential efficacy for alcohol and potentially, cocaine use disorders, that may occur in this population. PMID:24118434

  11. Impact of first-line protease inhibitors on predicted resistance to tipranavir in HIV-1-infected patients with virological failure

    Directory of Open Access Journals (Sweden)

    Chen Mao-Yuan

    2009-09-01

    Full Text Available Abstract Background Tipranavir (TPV is a recently approved nonpeptidic protease inhibitor (PI of HIV-1 and has been indicated for those infected with PIs-resistant HIV-1. However, in clinical practice, whether the HIV-1 from the patients with virological failure to the regimens containing first-line PIs remains susceptible to TPV/r may be questionable. Methods To assess the resistance levels to TPV of HIV-1 from patients with treatment failure to first-line PIs, patients who experienced virological failure were tested for genotypic resistance of HIV-1 since August 2006 in National Taiwan University Hospital. Patients were enrolled for this analysis if their failed regimens contained > 12 weeks of atazanavir or lopinavir/ritonavir (defined as ATV group and LPV/r group, respectively, but were excluded if they experienced both or other PIs. The levels of genotypic resistance to TPV/r were determined by TPV mutation score. Results Till May 2008, 21 subjects in ATV group and 20 subjects in LPV/r group were enrolled. The TPV mutation scores in subjects in LPV/r group were significantly higher than these in ATV group (median, 3 vs 1, P = 0.007. 95.2% subjects in ATV group and only 45% subjects in LPV/r group had an estimated maximal virological response to TPV/r (P Conclusion Cross-resistance from first-line PIs may impede the effectiveness of TPV/r-containing salvage therapy. TPV/r should be used cautiously for patients with virological failure to LPV/r especially long duration of exposure.

  12. Weighted West, Focused on the Indian Ocean and Cooperating across the Indo-Pacific: The Indian Navy’s New Maritime Strategy, Capabilities, and Diplomacy

    Science.gov (United States)

    2017-02-01

    ATV Advanced Technological Vehicle AUSINDEX Australia-India Exercise C4ISR Command, Control, Communications, Computers, Intelligence , Surveillance...2 This analysis of India’s Navy is one of three reports for a CNA study of U.S.-India naval and defense cooperation. For the other reports...Defense_Strategic_Guidance.pdf, 2. 25 Gurpreet Khurana, “’Net Security Provider’ Defined: An Analysis of India’s New Maritime Strategy-2015,” http://cimsec.org

  13. HOT BRICK III Airworthiness Evaluation OV-1D Airplane

    Science.gov (United States)

    1974-11-01

    endorsement Or approval of Ilse iase of the commercial hardware and software . UINCLASSIFIEI) SECt.ATV CLASI.FI, - TNOf T*IS PAGE ~ fc*y,,t USAAEFA -42...crew with an adequate cue to approaching the stall angle of attack. Single- Enine Control Margins 1). The single-engine control margins were evaluated in...toward the operating engine. Sinile- Enine Minimum Control Airspeed 7. The single-engine minimum cortrol airspeed tests were conducted by stabilizing the

  14. Kas Eestis on igameheõigust liiga palju ja seda peaks kärpima?

    Index Scriptorium Estoniae

    2007-01-01

    Küsimusele vastavad Tartu Ülikooli tsiviilõiguse professor Paul Varul, Tartu metskonna metsaülem Toomas Haas, Riikliku Looduskaitsekeskuse Lääne-Hiiu regiooni direktor Kaja Lotman, Tartu jahindusklubi direktor Jaak Volmer, ELF-i nõukogu liige, merebioloog Mart Jüssi, ATV-matkade korraldaja Antti Reiljan, loodusfotograaf Arne Ader ja Eesti Seiklusturismi Assotsiatsiooni juhatuse liige Paap Kõlar

  15. Automated attenuation-based tube voltage selection for body CTA: Performance evaluation of 192-slice dual-source CT

    Energy Technology Data Exchange (ETDEWEB)

    Winklehner, Anna; Gordic, Sonja; Lauk, Eliane; Frauenfelder, Thomas; Alkadhi, Hatem; Husarik, Daniela B. [University Hospital Zurich, Institute for Diagnostic and Interventional Radiology, Zurich (Switzerland); Leschka, Sebastian [University Hospital Zurich, Institute for Diagnostic and Interventional Radiology, Zurich (Switzerland); Division of Radiology and Nuclear Medicine, St. Gallen (Switzerland)

    2015-08-15

    To assess radiation dose and image quality in body CT-angiography (CTA) with automated attenuation-based tube voltage selection (ATVS) on a 192-slice dual-source CT (DSCT). Forty patients (69.5 ± 9.6 years) who had undergone body CTA with ATVS (ref.kVp 100, ref.mAs 90) using a 2x192-slice CT in single-source mode were retrospectively included. All patients had undergone prior CTA with a 2x128-slice CT and ATVS with identical imaging and contrast media protocols, serving for comparison. Images were reconstructed with iterative reconstruction at similar strength levels. Radiation dose was determined. Image quality was assessed semi-quantitatively (1:excellent, 5:non-diagnostic), aortic attenuation, noise and CNR were determined. As compared to 128-slice DSCT, 192-slice DSCT selected tube voltages were lower in 30 patients (75 %), higher in 3 (7.5 %), and similar in 7 patients (17.5 %). CTDI{sub vol} was lower with 192-slice DSCT (4.7 ± 1.9 mGy vs. 5.8 ± 2.1 mGy; p < 0.001). Subjective image quality, mean aortic attenuation (342 ± 67HU vs. 268 ± 67HU) and CNR (9.8 ± 2.5 vs. 8.2 ± 2.9) were higher with 192-slice DSCT (all p < 0.01), all datasets being diagnostic. Our study suggests that ATVS of 192-slice DSCT for body CTA is associated with an improved image quality and further radiation dose reduction of 19 % compared to 128-slice DSCT. (orig.)

  16. Environmental Assessment: Construct Miscellaneous Services Recreation Area at Grand Forks AFB, North Dakota

    Science.gov (United States)

    2004-03-15

    DATA OS Nov03 1ST AJ< ’IT"’"< ~.CL~ "VVI GRANO FORKS AFB, NORTH DAKOTA A TV Trainin /Misc. Services Recreation/ Land Use Chan e/Mass Parkin NA N...PF(AMC) FY 2004 MILITARY CONSTRUCTION DATA 05 Nov03 AS!" .IlLlA TIONNO lCCAliOH GRANO FORKS AFB. NORTH DAKOTA ATV Trainin /Misc. Services

  17. Injuries related to off-road vehicles in Canada.

    Science.gov (United States)

    Vanlaar, Ward; McAteer, Heather; Brown, Steve; Crain, Jennifer; McFaull, Steven; Hing, Marisela Mainegra

    2015-02-01

    Off-road vehicles (ORVs; this includes snowmobiles, all-terrain vehicles or ATVs and dirt bikes) were once used primarily for work and travel. Such use remains common in Canada, although their recreational use has also gained popularity in recent years. An epidemiological injury profile of ORV users is important for better understanding injuries and their risk factors to help inform injury prevention initiatives. The Traffic Injury Research Foundation (TIRF) partnered with the Public Health Agency of Canada (PHAC) to analyze the epidemiology of ORV-related injuries. The primary aim was to assess crashes and injuries in Canada, including the extent of alcohol involvement. Secondly, the burden of injury among children and teen ORV drivers in Canada, as well as passengers, was investigated. Descriptive and inferential epidemiological statistics were generated using the following data sources: first, TIRF's National Fatality Database, which is a comprehensive, pan-Canadian, set of core data on all fatal motor vehicle crashes; second, TIRF's Serious Injury Database, which contains information on persons seriously injured in crashes; and, third, PHAC's Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP), a surveillance system currently operating in the emergency departments of some pediatric and general hospitals across Canada. Exposure data have been used in the analyzes where available. Between 1990 and 2010, fatality rates increased among ATV and dirt bike operators. The fatality rate among snowmobilers declined during this period. Of particular concern, among fatally injured female ATV users, children aged 0-15 years comprised the highest proportion of any age group at 33.8%. Regarding alcohol use, among fatally injured snowmobile and ATV/dirt bike operators tested for alcohol, 66% and 55% tested positive, respectively. Alcohol involvement in adult ORV crashes remains an important factor. In light of the growing popularity of ORVs, prevention and

  18. Reduced radiation dose and improved image quality at cardiovascular CT angiography by automated attenuation-based tube voltage selection: intra-individual comparison

    Energy Technology Data Exchange (ETDEWEB)

    Krazinski, Aleksander W.; Silverman, Justin R. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Meinel, Felix G.; Geyer, Lucas L. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Ludwig-Maximilians-University Hospital, Institute for Clinical Radiology, Munich (Germany); Schoepf, U.J. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Division of Cardiology, Department of Medicine, Charleston, SC (United States); Canstein, Christian [Siemens Healthcare, CT Division, Malvern, PA (United States); De Cecco, Carlo N. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); University of Rome ' ' Sapienza' ' - Polo Pontino, Department of Radiological Sciences, Oncology and Pathology, Latina (Italy)

    2014-11-15

    To evaluate the effect of automated tube voltage selection on radiation dose and image quality at cardiovascular CT angiography (CTA). We retrospectively analysed paired studies in 72 patients (41 male, 60.5 ± 16.5 years), who had undergone CTA acquisitions of the heart or aorta both before and after the implementation of an automated x-ray tube voltage selection algorithm (ATVS). All other parameters were kept identical between the two acquisitions. Subjective image quality (IQ) was rated and objective IQ was measured by image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and figure of merit (FOM). Image quality parameters and effective dose were compared between acquisitions. Overall subjective image quality improved with the percentage of cases scored as adequate or higher increasing from 79 % to 92 % after implementation of ATVS (P = 0.03). SNR (14.1 ± 5.9, 15.7 ± 6.1, P = 0.009), CNR (11.6 ± 5.3, 13.2 ± 5.6, P = 0.011), and FOM (19.9 ± 23.3, 43.8 ± 51.1, P < 0.001) were significantly higher after implementation of ATVS. Mean image noise (24.1 ± 8.4 HU, 22.7 ± 7.1 HU, P = 0.048) and mean effective dose (10.6 ± 5.9 mSv, 8.8 ± 5.0 mSv, P = 0.003) were significantly lower after implementation of ATVS. Automated tube voltage selection can operator-independently optimize cardiovascular CTA image acquisition parameters with improved image quality at reduced dose. (orig.)

  19. 动词-ing形式——中考常考不衰的内容

    Institute of Scientific and Technical Information of China (English)

    李翔

    2006-01-01

    动词-ing形式是中考常考不衰的内容之一,下面是常跟v-ing形式的动词或结构: keep+v-ing keepsb+v-ing keep on+v-ing enjoy+v-ing finish+v-ing have fun+v-ing have problems+v-ing be good at+v-ing

  20. Effect of mitochondrial KATP on Atovastatin's cardiac function protection%线粒体KATP在阿托伐他汀心功能保护效应中的作用

    Institute of Scientific and Technical Information of China (English)

    陈曼华; 周逸; 刘锦华; 张利芸

    2008-01-01

    目的 观察阿托伐他汀(ATV)对心肌缺血/再灌注损伤的影响以及线粒体ATP敏感性钾通道(mito KATP)在其中的作用.方法 将兔随机分成缺血/再灌注模型对照组(control组)、ATV组、ATV+5-羟癸酸(5-HD)组、5-HD组.进行40 min局部缺血和240 min再灌注,观察各组血流动力学、血液生物化学、线粒体ATP合成能力([ATP]m).结果 缺血/再灌注使左室发展压(LVDP)和压力上升最大速率(+dp/dtmax)均显著下降(均P<0.01);3 d ATV10 mg/(kg·d)预处理使缺血/再灌注后LVDP和+dp/dtmax的下降幅度显著降低(均P<0.01),并且降低CK-MB和LDH-1、提高[ATP]m;ATV+5-HD组LVDP和+dp/dtmax的下降幅度、CK-MB、LDH-1、[ATP]m均和对照组无明显差异.结论 ATV预处理通过激活mito KATP改善缺血/再灌注后左室收缩功能,mito KATP是KATP途径的主要作用位点.