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Sample records for ju hsin fu

  1. JU

    African Journals Online (AJOL)

    User

    community setting, and whereby both students and society could benefit from each other, ... setting to introduce problem solving, student centered learning process for ... Information technology: this is a skill which grew as the resources in JU.

  2. Chinese Middle Classes: Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2018-01-01

    Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846......Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846...

  3. Artemis JU and Eniac JU Projects with Czech Participation

    Czech Academy of Sciences Publication Activity Database

    Kadlec, Jiří; Nedvědová, K.

    -, special issue (2013), s. 6-9 ISSN 1210-9592 R&D Projects: GA MŠk(CZ) LE13020 Keywords : ARTEMIS JU * ENIAC JU * embedded systems * microelectronics * European Technology Platforms * FP7 * ICT Subject RIV: AF - Documentation, Librarianship, Information Studies http://library.utia.cas.cz/separaty/2013/ZS/kadlec-artemis ju and eniac ju projects with czech participation.pdf

  4. FuNNy

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    2005-01-01

    language, called FuNNy language) to C. The C learning library contains the learning algorithm. The generated C code is simple standard C and therefore it can be applied to all computers with a C-compiler. The learning algorithm is either a gradient descend method based on a numerical calculation...... of the gradient or a random search method. The input fuzzyfication can be described by four different kinds of membership functions. The output fuzzyfication is based on singletons. The rule base can be written in a natural language. The result of the learning is a new version of the fuzzy system described......The purpose of this paper is to describe a tool that is easy to use for implementing self learning fuzzy systems. This tool which is called FuNNy generates fuzzy systems. The tool consists of a compiler and a C learning library. The compiler translates a fuzzy system (written in a dedicated...

  5. The FU Orionis mechanism

    International Nuclear Information System (INIS)

    Larson, R.B.

    1980-01-01

    The large but temporary increase in radius accompanying the recurrent flare-ups of the FU Ori stars can be produced only by strong transient heating of a thin outer layer of the star. Simple composite polytropic models show that the observed changes in radius and luminosity can be accounted for if the outer 0.5 per cent of the mass gains a thermal energy comparable to the kinetic energy it would have in rapid rotation. The models also imply that the masses of the FU Ori stars are near 1 solar mass. The most plausible heating mechanism is an instability due to rapid rotation, and it is suggested that the secular instability of a convective rotating star to bar-like deformations is responsible; this will produce strong shocks, turbulence, and heating of the outermost layers of the star. Matter will also be ejected, and this could account for much of the mass and angular momentum lost from young stars. The most luminous T Tauri stars may have experienced recent FU Ori flare-ups and may still be a magnitude or more brighter than normal. (author)

  6. [Study on the first translated obstetrics book Tai chan ju yao (Essentials in Obstetrics)].

    Science.gov (United States)

    Wu, M

    2018-01-28

    In 1893, Wan Tsun-mo translated and published Tai chan ju yao ( Essentials in Obstetrics ), the first monograph of western obstetrics in modern China, symbolizing the independence of obstetrics from such maternal and child books as Fu ying xin shuo and Fu ke jing yun tu shuo , which occupies an important position in the history of the development of modern Chinese obstetrics. The book introduced anatomy, physiology, pathology, embryology, diagnostics, surgery, pharmacology and other knowledge of obstetrics in a catechismal form, and had a detailed discussion of such advanced obstetrical technologies as antiseptic, anesthesia, forceps and cesarean section for the first time.Judging from the content and translation of Tai chan ju yao , this book has already possessed the basic knowledge system of modern obstetrics, though the translation appeared to be somewhat jerky and not elegant and the terminology needing to be further improved, it was not only used as an important medium for the introduction of obstetrical knowledge, but also of great clinical value.However, its influence was so weak that later researchers seldom mentioned this book.

  7. - In vivo monitoring of 5-FU

    OpenAIRE

    Lucas, Susanne

    2010-01-01

    The aim of the present study was to establish the in vivo-monitoring of the enrichment of 5-FU liposomes in liver and liver metastases by MRI methods. Relative signal intensities of liver and tumor tissue were determined. After sacrifying animals concentrations of 5-FU and it´s active intracellular metabolite M3 were measured by HPLC techniques. We used CC531 adenocarcinoma in the liver of WAG/Rij rats as a standardized liver tumor model in our investigatio...

  8. FuSuMaTech workshop

    CERN Multimedia

    Olofsson, Simon

    2018-01-01

    The goal of the FuSuMaTecH IP workshop, organised at CERN Ideaquare 19-20 April, was to educate superconductivity and magnet experts about intellectual property. About 30 participants from multiple institutes and companies worked together in this two day interactive program which was facilitated by CERN Knowledge Transfer. Great progress was made in shaping the FuSuMaTech industrial demonstrator projects as well as the R&D&I subjects.

  9. VARNOSTNA POLITIKA NA PODROČJU INFORMATIKE

    OpenAIRE

    Šavor, Gašper

    2011-01-01

    Informacijska tehnologija postaja vse bolj pomemben del poslovanja vsakega podjetja ter ţivljenja vsakega posameznika. Zato je v interesu vseh, da so ključne informacije dobro zaščitene. V prvem delu diplomske naloge smo predstavili informacijske sisteme, njihovo delitev ter vrste. Prav tako smo podrobneje predstavili ţivljenjski cikel ter 4-stopenjski model razvoja informacijskega sistema. V osrednjem delu naloge smo se osredotočili na nevarnosti na področju informatike ter vrste zašči...

  10. 5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

    Directory of Open Access Journals (Sweden)

    Iwao Sasaki

    2010-09-01

    Full Text Available 5-Fluorouracil (5-FU is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

  11. Innovate the Teaching of Taiwaness History: An Application of Multimedia Distance Learning—A Web-site Construction Sample of Shih Hsin University

    Directory of Open Access Journals (Sweden)

    Shaw-Fong Lee

    2004-03-01

    Full Text Available Traditionally, the teaching of history course mostly utilizes face to face instruction and oral presentation. Along with the development of educational technology, the teaching methods could be more various such as using internet and multimedia. Literature reviews also indicate that using internet and multimedia may improve the effect of learning and teaching. This paper explores the development of a web-based instructional system for the course of Taiwanese History at Shih Hsin University.The result and the product of this development project is the web site, http://distance.shu.edu.tw/taiwan/list.htm. The content of the web-site includes instructional materials such as animations, videos, pictures, texts, historical maps, and so on. The developmental methods used in this project use curriculum design, survey, interview, review of literatures and focus group discussion.[Article content in Chinese

  12. y Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Socorro Arzaluz Solano

    2006-01-01

    Full Text Available El artículo aborda la aplicación del Programa Hábitat, diseñado por el Gobierno de Vicente Fox en 2002, en dos ciudades fronterizas: Nogales, Sonora, y Ciudad Juárez, Chihuahua. Se analiza la implantación del programa atendiendo sus particularidades, entre otros aspectos, se señalan los diferentes agentes que intervinieron en la ejecución de Hábitat, que pese a la claridad de las reglas, fueron diferentes en cada caso. También, las forma s de participación ciudadana promovidas por los gobiernos locales en ambos casos. Se presentan una reflexión final sobre el desarrollo de Hábitat en la frontera norte, y algunas recomendaciones.

  13. THE ORIGIN OF ASTEROID 162173 (1999 JU3)

    International Nuclear Information System (INIS)

    Campins, Humberto; De León, Julia; Morbidelli, Alessandro; Gayon-Markt, Julie; Delbo, Marco; Michel, Patrick; Licandro, Javier

    2013-01-01

    Near-Earth asteroid (162173) 1999 JU 3 (henceforth JU 3 ) is a potentially hazardous asteroid and the target of the Japanese Aerospace Exploration Agency's Hayabusa-2 sample return mission. JU 3 is also a backup target for two other sample return missions: NASA's OSIRIS-REx and the European Space Agency's Marco Polo-R. We use dynamical information to identify an inner-belt, low-inclination origin through the ν 6 resonance, more specifically, the region with 2.15 AU 3 is 0.07 ± 0.01, and this inner-belt region contains four well-defined low-albedo asteroid families (Clarissa, Erigone, Polana, and Sulamitis), plus a recently identified background population of low-albedo asteroids outside these families. Only two of these five groups, the background and the Polana family, deliver JU 3 -sized asteroids to the ν 6 resonance, and the background delivers significantly more JU 3 -sized asteroids. The available spectral evidence is also diagnostic; the visible and near-infrared spectra of JU 3 indicate it is a C-type asteroid, which is compatible with members of the background, but not with the Polana family because it contains primarily B-type asteroids. Hence, this background population of low-albedo asteroids is the most likely source of JU 3

  14. Teaching Tu Fu on the Night Shift.

    Science.gov (United States)

    Brady, Philip

    1995-01-01

    Describes a teacher's unsuccessful attempt to introduce the poetry of Tu Fu, a wayward bureaucrat of the T'ang dynasty, to a class of part-time students. Uses his students' resistance to this poetry as an occasion to discuss the importance of personal responses to poetry, as opposed to "correct" academic responses. (TB)

  15. O direito como juízo

    Directory of Open Access Journals (Sweden)

    Denise Maria Weiss de Paula Machado

    1988-07-01

    Full Text Available This study presents a synthetic and personal view of the consequences arising from the notion of law as justice. For Kelsen, in this "Theory of pure law", human conduct produce facts, justly or injust1y, that become characterized as legal norms. Human behavior is determined by acts of reason, that are defined by a representative (a judge, and then are used as valid norms of justice. The conception of law is, therefore, represented by an ideal object, rational and only apprehensible through abstract processes, following the views of Kelsenians. Without any intent to criticize the "great master of Vienna", a search of the text demonstrates that a neutral ideology, concerning the comprehension and application of law, does not and can not exists law can not depart from empirical reality when following its purpose of promoting the liberty and development of society.O presente texto tem por finalidade apresentar uma visão sintética e pessoal das conseqüências decorrentes da noção do direito como juízo. Para KELSEN, em sua "Teoria pura do direito", a conduta humana produz fatos jurídicos ou injurídicos, conforme assim os caracterizam as normas jurídicas. A conduta humana é determinada por uma razão de agir, que é definida pela representação juízo que o homem tem da norma jurídica 'vigente. A concepção do direito é, pois, representada por um objeto ideal, racional e somente apreensível através de um processo de abstração, segundo a visão Kelseniana. Sem a mínima pretensão de formular críticas ao grande Mestre de Viena, procura o texto demonstrar que a neutralidade ideológica, para a compreensão e aplicação do direito, não existe e nem pode existir, eis que o direito não pode se afastar da realidade empírica, a fim de que possa alcançar sua finalidade de promover a libertação e a evolução da sociedade.

  16. Implementation of IPv6 at the PřF JU

    OpenAIRE

    JOUDAL, Jakub

    2011-01-01

    Aspects of IPv6 implementation. Is the current network structure capable of deploying IPv6 JU? What would this change mean? What will be the financial costs of transition? The advantages of IPv6 in terms of high schools.

  17. Cummings/Ju - Harvard; Emory | Division of Cancer Prevention

    Science.gov (United States)

    Principal Investigator: Richard D Cummings, PhDInstitution: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Principal Investigator: Tongzhong Ju, MD, PhDInstitution: Emory University, Atlanta, GA |

  18. THE JU-LMU LINK FOR MEDICAL EDUCATION: EXCHANGING ...

    African Journals Online (AJOL)

    Anke Wanger, Minas Woldetsadik, Matthias Siebeck

    Jimma University (JU) in Ethiopia and Ludwig-Maximilians-University (LMU) in ... For the future we plan to integrate Ethiopian students coming to LMU ... travelling to Germany for becoming PBL tutors will participate in LMU's regular PBL-.

  19. Strategic interactions: Games of the Ju|'hoan.

    Science.gov (United States)

    de Voogt, Alex

    2017-12-01

    Three strategic games played by the Ju|'hoan-a board, a card, and a gesture game-complicate the rhetorics that suggest an evolutionary or psychological significance of play. They are mostly played by adults, although every individual adult does not necessarily engage in each game. The Ju|'hoan card and board game practices were transmitted through contact across large parts of Botswana and Namibia, while the gesture game n!àì has been known in other San communities. It suggests that the significance of strategic games is more likely found in its potential for social interaction (i.e., allowing to overcome cultural divides) than in evolution and psychology. Within the anthropological literature, strategy games were thought to be absent in egalitarian societies, such as that of the Ju|'hoan. Here, the roles of power, competition, and winning were thought to be disruptive and unwanted. A closer examination of the details behind the Ju|'hoan games shows that not only were strategy games adopted and adapted from neighboring societies but that the game of n!àì was developed by the Ju|'hoan into a competitive one. The evolutionary or psychological significance of play is informed by studies on individual play, children's play, and games with informal rules. When considering strategic games throughout history, it is their role of facilitator rather than the playing practice itself that makes games relevant across languages, cultural divides, and sociopolitical boundaries.

  20. Zuordnungsprozesse bei Fußballzuschauern - Zur Salienz teambezogener Kategorien

    OpenAIRE

    Roschmann, Regina

    2013-01-01

    Sport im Allgemeinen und Fußball im Besonderen erfreuen sich nicht nur unter aktiven Sportlern, sondern auch unter Zuschauern aktuell hoher Beliebtheit. Angesichts teils enormer Einschaltquoten scheint es wahrscheinlich, dass Fußballspiele nicht nur von Fans der beteiligten Mannschaften verfolgt werden. Dies kann sowohl gänzlich neutrale Zuschauer als auch Anhänger anderer Teams betreffen. Während Fans allerdings durch die Literatur bereits ausführliche Aufmerksamkeit erfahren haben und durch...

  1. Health benefits of Kung Fu: a systematic review.

    Science.gov (United States)

    Tsang, Tracey Wai Man; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2008-10-01

    The Chinese martial arts (Kung Fu) have existed for centuries and are generally accepted as being beneficial for health without much empirical data. The aim of this systematic review was to assess the health effects of "hard" Kung Fu styles by performing electronic and manual searches of the literature. The aspects of health and the Kung Fu style examined varied between most studies; in some cases, the martial art group consisted of practitioners of other martial art styles also. Of 2103 references identified, only nine papers were eligible and reviewed. All were observational studies, observing a range of health aspects possibly related to Kung Fu training or performance. Our findings suggest that there is no evidence that Kung Fu practice is associated with the prevention or treatment of any health condition. However, as a moderate- to high-intensity form of aerobic exercise, it may confer benefits similar to those attributed to other aerobic training modalities. However, this hypothesis remains to be tested in clinical trials. Physiological benefits (e.g., aerobic capacity and bone density) may be associated with long-term Kung Fu practice. Future research in this area should adopt experimental designs, clearly identifying eligibility criteria, testing and training protocols, and include health-related outcomes and documentation of adverse events, to advance knowledge in this field.

  2. Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

    Directory of Open Access Journals (Sweden)

    Kravik Katherine L

    2006-05-01

    Full Text Available Abstract Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate and strong resistance to 5-FU, respectively, markedly-reduced levels of 5-FU-induced apoptosis, and alterations in expression levels of a number of key cell cycle- and apoptosis-regulatory genes as a result of resistance development. The aim of the present study was to determine potential differential responses to 8 and 24-hour 5-FU treatment in these resistant cell lines. We assessed levels of 5-FU uptake into DNA, cell cycle effects and apoptosis induction throughout treatment and recovery periods for each cell line, and alterations in expression levels of DNA damage response-, cell cycle- and apoptosis-regulatory genes in response to short-term drug exposure. Results 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA, cell cycle-regulatory (CDKN1A, and apoptosis-regulatory pathways (FAS, and apoptosis induction in the parental and resistant cell lines. Levels of 5-FU incorporation into DNA were similar for the cell lines. The pattern of cell cycle progression during recovery demonstrated consistently that the 5-FU-resistant cell lines had the smallest S phase fractions and the largest G2(/M fractions. The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days compared to the other two cell lines. The moderately 5-FU-resistant ContinB cell line had comparatively lower apoptotic levels than the parental cells during treatment and recovery

  3. Kritik Atas Modernitas Dalam Novel Bilangan Fu Karya Ayu Utami

    Directory of Open Access Journals (Sweden)

    Bramantio Bramantio

    2015-06-01

    Full Text Available Artikel ini bertujuan untuk mengungkap kritik atas modernitas dalam novel Bilangan Fu karya Ayu Utami. Dengan memanfaatkan naratologi Tzvetan Todorov, dapat dipahami aspek verbal Bilangan Fu, yaitu sudut pandang, pencerita, dan tuturannya. Berdasarkan penceritaannya, novel ini merupakan novel polifonik, karnivalistik, sekaligus metafiksi. Berdasarkan kontennya, novel ini menghadirkan sejumlah kritik atas modernitas, khususnya berkaitan dengan semangat modernitas yang cenderung melihat segala sesuatu secara monodimensional, hanya ada satu kebenaran, dan liyan diabaikan. Bilangan Fu merupakan novel yang merefleksikan zamannya. Novel ini berhasil menyegarkan cara pandang masyarakat Indonesia, atau setidaknya menghadirkan sesuatu untuk dipikirkan dan dipertimbangkan kembali, berkaitan dengan diri, lingkungan, dan semesta raya. Novel ini mengembalikan manusia ke hakikatnya, yaitu kemanusiaan. Abstract: This article aims to reveal criticism on modernity in Ayu Utami’s novel Bilangan Fu. Tzvetan Todorov’s theory of narrative provided a framework to understand the novel’s verbal aspects, which are point of view, narrator, dan its voice. Based on its narrative, this novel is polyphonic, carnivalistic, and metafictional. Based on its content, it presents criticism on modernity, particularly on spirit of modernity that tends to see everything in monodimensional; there is only one truth, and the other is ignored. Bilangan Fu is a novel that reflects its time. It successfully refreshes the perspective of Indonesian society, or at least brings something to think about, related to the self, environment, and the universe. In the end, it brings back human being to their core, their humanity. Key Words: novel; point of view; narrator; criticism; modernity

  4. Fučík spectra for vector equations

    Directory of Open Access Journals (Sweden)

    Christian Fabry

    2000-01-01

    Full Text Available Let $L:\\hbox{dom} L\\subset L^2(\\Omega;R^N\\rightarrow L^2(\\Omega;R^N$ be a linear operator, $\\Omega$ being open and bounded in $R^M$. The aim of this paper is to study the Fu\\v c\\'\\i k spectrum for vector problems of the form $Lu=\\alpha Au^+ -\\beta Au^-$, where $A$ is an $N\\times N$ matrix, $\\alpha, \\beta$ are real numbers, $u^+$ a vector defined componentwise by $(u^+_i=\\max\\{u_i,0\\}$, $u^-$ being defined similarly. With $\\lambda^*$ an eigenvalue for the problem $Lu=\\lambda Au$, we describe (locally curves in the Fučík spectrum passing through the point $(\\lambda^*,\\lambda^*$, distinguishing different cases illustrated by examples, for which Fučík curves have been computed numerically.

  5. Infection witb'l\\:fued GastrointestinafNematOde Parasites ',' .:

    African Journals Online (AJOL)

    Resistance of Three Strains 'of Sinall EasL~friCan 'Goats to Artificial. Infection witb'l\\:fued ... TWC and mortality among the SEA gOat strains, Gogo goats had significantly lower FEC (606 ejJg). ]WC (529) and .... Chi-square test. This involved ...

  6. X-shooter spectroscopy of FU Tauri A

    Science.gov (United States)

    Stelzer, B.; Alcalá, J. M.; Scholz, A.; Natta, A.; Randich, S.; Covino, E.

    2013-03-01

    We have analyzed a broad-band optical and near-infrared spectrum of FU Tau A, which is a presumed young brown dwarf in the Taurus star forming region that has intrigued both theorists and observers by its overluminosity in the Hertzsprung-Russell (HR) diagram with respect to standard pre-main sequence evolutionary models. FU Tau A is brighter than any other Taurus member of the same or similar spectral type, and various phenomena (accretion, activity, binarity) have been put forth as possible explanations. The new data, obtained with the X-shooter spectrograph at the Very Large Telescope, include an unprecedented wealth of information on stellar parameters and simultaneously observed accretion and outflow indicators for FU Tau A. We present the first measurements of gravity (log g = 3.5 ± 0.5), radial velocity (RV = 22.5 ± 2.9 km s-1), rotational velocity (vsini = 20 ± 5 km s-1), and lithium equivalent width (EWLi = 430 ± 20 mÅ) for FU Tau A. From the rotational velocity and the published period we infer a disk inclination of i ≳ 50°. The lithium content is much lower than theoretically expected for such a young very low-mass object, adding another puzzling feature to this object's properties. We determine the mass accretion rate of FU Tau A from comparison of the luminosities of 20 emission lines to empirical calibrations from the literature and find a mean of log Ṁacc [M⊙/yr] = -9.9 with standard deviation σ = 0.2. The accretion rate determined independently from modeling of the excess emission in the Balmer and Paschen continua is consistent with this value. The corresponding accretion luminosity is too low to make a significant contribution to the bolometric luminosity. Strong magnetic activity affecting the stellar parameters or binarity of FU Tau A, both combined with extreme youth, may be responsible for its position in the HR diagram. The existence of an outflow in FU Tau A is demonstrated through the first detection of forbidden emission lines

  7. Rüütel kutsus Juštšenko Eestisse

    Index Scriptorium Estoniae

    2005-01-01

    President Arnold Rüütel saatis Viktor Juštšenkole õnnitluse presidendivalimistel saavutatud edu puhul, kutsudes teda Eestisse visiidile. Ilmunud ka Vaba Eesti Sõna = Free Estonian Word (2005) 18. jaan., lk. 2

  8. First Results from the AKARI FU-HYU Mission Program

    Science.gov (United States)

    Pearson, C.; Serjeant, S.; Takagi, T.; Jeong, W.-S.; Negrello, M.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M.

    2009-12-01

    The AKARI FU-HYU mission program has carried out mid-infrared imaging of several well studied Spitzer fields. This imaging fills in the wavelength coverage lacking from the Spitzer surveys and gives an extremely high scientific return for minimal input for AKARI. We select fields already rich in multi-wavelength data from radio to X-ray wavelengths and present the results from our initial analysis in the GOODS-N field. We utilize the comprehansive multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. These colour-colours diagrams are used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field.

  9. Ring-shaped nebulae around FU Orionis stars

    International Nuclear Information System (INIS)

    Goodrich, R.W.

    1987-01-01

    Observational data on the morphology and spectra of the nebulae surrounding V1057 Cyg, V1515 Cyg, and V1735 Cyg stars are presented and studied. The data reveal that V1735 Cyg is more highly reddened than the nebula and the spectra of all three nebulae are from reflection. A simple model for the dust shell is proposed and it is argued that the shells may indicate a relatively advanced evolutionary state for the FU Orionis star. The relation between the shells and the evolution of the stars is examined. The models of Herbig (1977), Mould et al. (1978), Larson (1980), and Hartmann and Kenyon (1985), which are utilized to analyze the FU Orionis outburst phenomenon, are tested. 23 references

  10. Visuospatial attention and motor skills in kung fu athletes.

    Science.gov (United States)

    Muiños, Mónica; Ballesteros, Soledad

    2013-01-01

    The present study compared the performance of a group of sixteen kung fu athletes with that of a control group of fourteen nonathletes on a speeded visuospatial task and a hand-tapping motor task. In the visuospatial task the results showed that athletes were faster than the control participants when stimuli were presented at the periphery of the visual field at a middle and high presentation speed with short interstimulus intervals. Athletes were also significantly faster than nonathlete participants when performing motor actions such as hand-tapping with their dominant hand but groups did not differ with the nondominant hand. These results support the view that athletes perform some speeded visuospatial and motor tasks faster than nonathletes under certain conditions. The findings suggest that, after several years of practice, kung fu athletes develop certain skills that allow them to perform motor speed maneuvers under time pressure conditions.

  11. En procesorienteret miljøvurdering af F&U

    DEFF Research Database (Denmark)

    Lyhne, Ivar

    Miljøperformance af fremtidens energiteknologier defineres i høj grad i de tidlige F&U aktiviteter. Energinet.dk har i flere år miljøvurderet ForskEL-programmet og i dette projekt forbedres systemets nytte ved at muliggøre øgede krav til programmets samlede performance og følge op på projekternes...

  12. THE MID-INFRARED EVOLUTION OF THE FU ORIONIS DISK

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Jones, Olivia C.; Poteet, Charles A.; Sargent, Benjamin A. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Keller, Luke D. [Department of Physics and Astronomy, Ithaca College, Ithaca, NY (United States); Yang, Yao-Lun; Evans II, Neal J. [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Fischer, William J. [Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Rebull, Luisa M. [IPAC, Pasadena, CA 91125 (United States)

    2016-11-20

    We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer -IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ∼14%. We find that this decrease in luminosity occurs only at wavelengths ≲20 μ m. In particular, the continuum shortward of the silicate emission complex at 10 μ m exhibits a ∼12% (∼3 σ ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μ m continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ∼12–14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region.

  13. Chemoradiotherapy using platinum analogs/5-FU for advanced esophageal cancer

    International Nuclear Information System (INIS)

    Shibata, Shigeru; Kawasaki, Hitoshi; Nakai, Makoto; Morohashi, Hajime; Matsuya, Hideki; Yamada, Kyougo; Morita, Takayuki; Sasaki, Mutsuo

    2002-01-01

    We evaluated the efficacy of concurrent chemoradiotherapy (CRT) using cisplatin/nedaplatin and 5-fluorouracil (5-FU) for advanced esophageal cancer. Thirteen patients with locally advanced esophageal cancer (T4 cases) and 3 with recurrence of esophageal cancer were treated with radiotherapy (40-70 Gy) and 5-FU combined and cisplatin/nedaplatin concurrently. T4 patients who obtained down-staging by CRT also underwent esophagectomy. A complete response was obtained in one case, partial response in 8 cases, and no change in 7 cases. The overall response rate was 56.3%. A pathological complete response was obtained in one case in which curative resection was performed after CRT. Bone marrow suppression was observed in 68.8% and grade 3 and 4 bone marrow suppression was observed in 43.8%. Concurrent CRT using cisplatin/nedaplatin and 5-FU for advanced esophageal cancer has a high response rate and patients obtaining down-staging by CRT as a neoadjuvant therapy have a chance for long survival after curative resection in locally advanced cases. (author)

  14. Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori

    OpenAIRE

    Iļjenko, Ivonna

    2015-01-01

    Maģistra darba nosaukums ir „Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori”. Maģistra darba mērķis ir identificēt būtiskākos konfliktu izraisošos faktorus franšīzes devēju un franšīzes ņēmēju attiecībās, raksturot franšīzes praktisko pielietojumu un izstrādāt priekšlikumus franšīzes popularizēšanai un konfliktu novēršanai franšīzes attiecībās Latvijā. Darba pirmajā nodaļā raksturota franšīzes būtība, tās priekšrocības un trūkumi, konflikta process, konfliktu izraisošie...

  15. Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

    Science.gov (United States)

    Lutz, Manfred P; Wilke, Hansjochen; Wagener, D J Theo; Vanhoefer, Udo; Jeziorski, Krzysztof; Hegewisch-Becker, Susanna; Balleisen, Leopold; Joossens, Eric; Jansen, Rob L; Debois, Muriel; Bethe, Ullrich; Praet, Michel; Wils, Jacques; Van Cutsem, Eric

    2007-06-20

    This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

  16. Wavelet transform analysis of electromyography kung fu strikes data.

    Science.gov (United States)

    Neto, Osmar Pinto; Marzullo, Ana Carolina de Miranda

    2009-11-01

    In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP) values instead of root mean square (rms) values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF). EMG data of the deltoid anterior (DA), triceps brachii (TB) and brachioradialis (BR) muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023) for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007) for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners. Key PointsThe results show higher muscle activity and lower electromyography median frequencies for strikes with impact compared to strikes without.SSP results presented higher sensitivity and lower inter-subject coefficient of variations than rms results.Kung Fu palm strikes with impact may present better motor units' synchronization than strikes without.

  17. Patērētāju attieksme pret zīmolu "IKEA"

    OpenAIRE

    Aleksejenko, Dana

    2014-01-01

    Tēma ir “Patērētāju attieksme pret zīmolu “IKEA””.Pētījuma mērķis ir noskaidrot Latvijas iedzīvotāju, “IKEA” zīmola patērētāju un mazumtirgotāju viedokli, attieksmi un vērtējumu par zīmolu “IKEA”.Radošā daļa ir pamatota ar teorētisko daļu par:zīmola jēdzienu, patērētāju uzvedību, mārketinga komunikāciju un uzņēmumu internetā. Apakašnodaļās ir aprakstīta zīmola identitāte un zīmola vērtība, korporatīvais zīmols un korporatīvā identitāte.Metodoloģija ir izstrādāta vairākās pakāpēs,katras pakāpe...

  18. EU program fuel cells in 2012 - FCH JU Fuel Cell and Hydrogen Joint Undertaking; EU-program braensleceller 2012 - FCH JU Fuel Cell and Hydrogen Joint Undertaking

    Energy Technology Data Exchange (ETDEWEB)

    Ridell, Bengt

    2013-03-15

    An EU activity in fuel cell and hydrogen field are gathered since 2008 in a so called JU, Joint Undertaking, or as it is also referred to as JTI Joint Technology Initiative. The program will run 2008 - 2013 and covers in total 940 MEUR of which the EU Commission is funding 470 MEUR. The activities of the FCH JU are governed by a Governing Board which has 12 members, five from the Commission, one of the research group and 5 from the Industrial Group. The current agreement for the FCH JU / JTI is coming to an end, and the sixth and final call was released in January 2013 with the deadline of 22 May 2013. Funding from the Commission is made through the Seventh Framework Programme FP7, which ends in 2013. Next the Eighth Framework Programme called Horizon 2020 shall continue for the years 2014 - 2020. Five of the six calls are completed. From the four first calls there are 61 projects started which 6 have been completed. From the fifth announcement is further 27 projects selected for negotiation with the Commission and they will start soon. It is now working intensively to plan Horizon 2020. There are plans to continue the new FCH JU but nothing is decided either for this or for the budget for Horizon 2020. If the FCH Joint Undertaking shall continue in its present form as a Joint Undertaking it will require clear long-term commitments from the private sector and also from the Member States. Another issue is that the long-term research should also get space it has not been the case in the present FCH JU. There are several Swedish participants in the projects and in the working groups of the program. There are Swedish participants in 11 of the 68 projects launched so far. It is in the areas of Stationary systems, Transportation and Early Markets. Project manager for the project FCGEN is Volvo Technology AB. FCH JU has its own website, www.fch-ju.eu, which opened in 2010 when the organization of the program was taken over from the Commission to permanent organisation

  19. Force, reaction time, and precision of Kung Fu strikes.

    Science.gov (United States)

    Neto, Osmar Pinto; Bolander, Richard; Pacheco, Marcos Tadeu Tavares; Bir, Cynthia

    2009-08-01

    The goal was to compare values of force, precision, and reaction time of several martial arts punches and palm strikes performed by advanced and intermediate Kung Fu practitioners, both men and women. 13 Kung Fu practitioners, 10 men and three women, participated. Only the men, three advanced and seven intermediate, were considered for comparisons between levels. Reaction time values were obtained using two high speed cameras that recorded each strike at 2500 Hz. Force of impact was measured by a load cell. For comparisons of groups, force data were normalized by participant's body mass and height. Precision of the strikes was determined by a high speed pressure sensor. The results show that palm strikes were stronger than punches. Women in the study presented, on average, lower values of reaction time and force but higher values of precision than men. Advanced participants presented higher forces than intermediate participants. Significant negative correlations between the values of force and precision and the values of force and reaction time were also found.

  20. WAVELET TRANSFORM ANALYSIS OF ELECTROMYOGRAPHY KUNG FU STRIKES DATA

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Miranda Marzullo

    2009-11-01

    Full Text Available In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP values instead of root mean square (rms values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF. EMG data of the deltoid anterior (DA, triceps brachii (TB and brachioradialis (BR muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023 for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007 for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners

  1. Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda

    OpenAIRE

    Chen, Fu-jen

    2017-01-01

    In his article "Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda" Fu-Jen Chen situates his study within today's prevailing climate of global consumption to argue that the 2007 film Juno—featuring an unconventional portrayal of the adoption triad and a cynical detachment from public values—not only trivializes and depoliticizes the practice of adoption but also serves as an ideological supplement to today's global capitalism. Furthermore, Kung Fu Panda 1 & 2 (2008; 2...

  2. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression.

    Science.gov (United States)

    Wang, Weicheng; Guo, Wenjie; Li, Lele; Fu, Zan; Liu, Wen; Gao, Jian; Shu, Yongqian; Xu, Qiang; Sun, Yang; Gu, Yanhong

    2016-12-01

    5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU. Mechanism analysis showed that Andrographolide/5-FU co-treatment elevated apoptosis level of HCT116/5-FUR cells with highly increased level of BAX. By using biotin-Andrographolide pull down and cellular thermal shift assay, we found out that Andrographolide can directly target to BAX. Andrographolide-BAX interaction prevented BAX degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-FU resistance while BAX silence diminished this effect. Further, by analyzing patient samples who received 5-FU involved chemotherapy, we found that expression level of BAX is correlated with PFS. Our results here provide a novel combination treatment strategy, especially for patients with 5-FU-resistant tumors expressing low level of BAX. Meanwhile, we also proposed that BAX expression may be a predicted and prognosis marker of 5-FU involved chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. FuGEFlow: data model and markup language for flow cytometry

    Directory of Open Access Journals (Sweden)

    Manion Frank J

    2009-06-01

    Full Text Available Abstract Background Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. Methods We used the MagicDraw modelling tool to design a UML model (Flow-OM according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML. We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. Results The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow, which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets

  4. FuGEFlow: data model and markup language for flow cytometry.

    Science.gov (United States)

    Qian, Yu; Tchuvatkina, Olga; Spidlen, Josef; Wilkinson, Peter; Gasparetto, Maura; Jones, Andrew R; Manion, Frank J; Scheuermann, Richard H; Sekaly, Rafick-Pierre; Brinkman, Ryan R

    2009-06-16

    Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE) formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. We used the MagicDraw modelling tool to design a UML model (Flow-OM) according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML). We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow), which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets. Additional project documentation, including

  5. Inhibition effects of a negative electret 5-FU patch on the growth of a hypertrophic scar

    Science.gov (United States)

    Wang, YUAN; Lili, XU; Ping, HUANG; Xiaoqiang, AN; Lili, CUI; Jian, JIANG

    2018-05-01

    In this study, the hypertrophic scar (HS) model in rats was established. 5-fluorouracil (5-FU) patch, ‑1000 V and ‑2000 V polypropylene (PP) electret 5-FU patches were prepared and applied onto the wound. The in vitro permeation experiment was performed using the Franz diffusion cell system to determine the permeation cumulative amount and retention amount of 5-FU through/in scar skin. The inhibition effect of negative electret on growth of HS was studied by hematoxylin-eosin (HE) staining, Masson staining and the immunohistologicall methods. The permeation study indicated that a negative electret could enhance the permeation and retention of 5-FU through and in scar skin respectively. HE staining and Masson staining indicated a better effect for ‑1000 V and ‑2000 V electret 5-FU patches on HS inhibition after 28 d post-wounding compared with 5-FU patch. The immunohistological study showed much more reduced expressions of collegan type I, collegan type III, TGF-β1 and HSP47 in scar tissue after application of negative electret 5-FU patches than those of 5-FU patch. A negative electret 5-FU patch may be advantageous for HS treatment.

  6. Technological differences between açai and juçara pulps and their sorbets

    Directory of Open Access Journals (Sweden)

    Ana Paula Silva Siqueira

    2017-11-01

    Full Text Available Abstract Açai and juçara are palm trees that produce similar fruits. However, only the sale of açai is growing on the market for pulps and processed products for human consumption. The aim of this study was to compare açai and juçara pulps from the chemical, bioactive, rheological and technological points of view. Sorbets were elaborated with the pulps and evaluations were carried out regarding the antioxidant activity, polyphenols, anthocyanins, pH, acidity, soluble solids, ratio and colour. The pulps were evaluated rheologically and the sorbets for melting time. Juçara showed better results regarding the bioactive parameters (antioxidants ≈ 151 uM ferrous sulphate/ g and anthocyanins ≈ 77 mg.100g-1 and presented a more intense colour (Chroma 17. The pulps were physicochemically similar. The sorbet preserved much of the nutrients and presented a very intense colour, mainly in the juçara sorbet.

  7. Sindicatos en Ciudad Juárez: Historia y debilidad sindical

    Directory of Open Access Journals (Sweden)

    Cirila Quintero Ramírez

    1996-01-01

    Full Text Available This work analyzes the evolution of the labor unions in Ciudad Juárez for three decades of the maquiladora industry. Postulates as a main idea, the existence of a weakening of the labor unions in the rnaquiladoras as a consequence of two central factors: the absence of a labor union trajectory in the region, and the persistence of economical activities in Ciudad Juárez that depend on the American economy, and the existence of a factionalism inter and intralabor union in the main workers associations in the city, that has permitted the defeal of not onIy the official movements, but the independent ones too. The weakening ol the labor union. has also conducted to a policy ol apathy, conformity, and ol high colaboration with the investors, that has tumed the labor unions in Ciudad Juárez into an expression of subordinated labor unions, that legitimates their perrnanency in the rnaquiladoras are mostly to their link with investors than with their members. This article allows us to see two future sceneries in the city ol Ciudad Juárez: the accentuation of this kind of behavior in labor unions, or the disappearance ol labor unions in the maquiladoras.

  8. Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

    NARCIS (Netherlands)

    Lutz, M.P.; Wilke, H.; Wagener, D.J.T.; Vanhoefer, U.; Jeziorski, K.; Hegewisch-Becker, S.; Balleisen, L.; Joossens, E.; Jansen, R.L.; Debois, M.; Bethe, U.; Praet, M.; Wils, J.; Cutsem, E. van

    2007-01-01

    PURPOSE: This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. PATIENTS AND METHODS: A total of 145 patients

  9. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

    NARCIS (Netherlands)

    Reerink, O; Mulder, NH; Szabo, BG; Hospers, GAP

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU

  10. Kung-fu versus swimming training and the effects on balance abilities in young adolescents.

    Science.gov (United States)

    Baccouch, Rym; Rebai, Haithem; Sahli, Sonia

    2015-11-01

    Our purpose is to investigate the static balance control of young adolescents practicing kung-fu and swimming in order to find out which of these physical activities is the most effective in developing specific balance abilities in young adolescents. Comparative experimental study. University laboratory research. Three groups of 11-13-year-old boys (12 practicing Kung-Fu, 12 practicing swimming and 12 controls). Center of pressure (CoP) excursions were registered in upright bipedal and unipedal stances on a stabilometric force platform in eyes open (EO) and eyes closed (EC) conditions. Kung-fu practitioners control their balance (P Kung-fu training improved (P kung-fu practitioners. Both of these physical activities could be recommended for young adolescents as recreational or rehabilitation programs as they develop specific balance abilities that could be important for improving and maintaining optimal health. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. THE NATURE AND EVOLUTIONARY STATE OF THE FU ORIONIS BINARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Beck, Tracy L. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Aspin, C., E-mail: tbeck@stsci.edu, E-mail: caa@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2012-03-15

    In this paper, we present the results of our adaptive optics fed three-dimensional imaging spectroscopy study of the FU Orionis binary system. Although the 0.''5 separation companion to FU Ori is {approx}4 mag fainter, we have easily spatially resolved it in the J, H, and K infrared bands and extract high signal-to-noise spectra of the two stellar components from 1.15 to 2.4 {mu}m. We derive a spectral type of K5{sup +2}{sub -1} for FU Ori S based on the stellar photospheric absorption features and find that it is an actively accreting young star (M-dot{sub acc}{approx} (2-3) Multiplication-Sign 10{sup -8} M{sub Sun} yr{sup -1}) that is likely gravitationally bound to FU Ori. We have found that the continuum shape of FU Ori S is not well fit by our spectral modeling process, and this results in a large uncertainty in the line-of-sight extinction to the star. Yet, by placing FU Ori S on the Hertzsprung-Russell diagram and comparing its estimated location with evolutionary models, we find that it is best fit as a {approx}1.2 M{sub Sun} star with a likely age of less than {approx}2 Myr. If we assume coevality of the stellar components, we have thus placed an estimated age on the FU Ori system. Moreover, assuming the canonical model for the nature of FU Ori in that its optical and infrared absorption features arise primarily from the inner circumstellar disk around a {approx}0.3 M{sub Sun} star, we find that the fainter FU Ori S component is actually the more massive star in the system. Future monitoring of FU Ori S to investigate flux variability and orbital motion should further clarify the nature of this curious young binary.

  12. JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.

    Science.gov (United States)

    Bassen, David M; Vilkhovoy, Michael; Minot, Mason; Butcher, Jonathan T; Varner, Jeffrey D

    2017-01-25

    Ensemble modeling is a promising approach for obtaining robust predictions and coarse grained population behavior in deterministic mathematical models. Ensemble approaches address model uncertainty by using parameter or model families instead of single best-fit parameters or fixed model structures. Parameter ensembles can be selected based upon simulation error, along with other criteria such as diversity or steady-state performance. Simulations using parameter ensembles can estimate confidence intervals on model variables, and robustly constrain model predictions, despite having many poorly constrained parameters. In this software note, we present a multiobjective based technique to estimate parameter or models ensembles, the Pareto Optimal Ensemble Technique in the Julia programming language (JuPOETs). JuPOETs integrates simulated annealing with Pareto optimality to estimate ensembles on or near the optimal tradeoff surface between competing training objectives. We demonstrate JuPOETs on a suite of multiobjective problems, including test functions with parameter bounds and system constraints as well as for the identification of a proof-of-concept biochemical model with four conflicting training objectives. JuPOETs identified optimal or near optimal solutions approximately six-fold faster than a corresponding implementation in Octave for the suite of test functions. For the proof-of-concept biochemical model, JuPOETs produced an ensemble of parameters that gave both the mean of the training data for conflicting data sets, while simultaneously estimating parameter sets that performed well on each of the individual objective functions. JuPOETs is a promising approach for the estimation of parameter and model ensembles using multiobjective optimization. JuPOETs can be adapted to solve many problem types, including mixed binary and continuous variable types, bilevel optimization problems and constrained problems without altering the base algorithm. JuPOETs is open

  13. γ-Tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2.

    Science.gov (United States)

    Takano, Hideyuki; Momota, Yukihiro; Kani, Kouichi; Aota, Keiko; Yamamura, Yoshiko; Yamanoi, Tomoko; Azuma, Masayuki

    2015-04-01

    Chemotherapy-induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ-tocotrienol on the 5-FU-induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5-FU and γ-tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5-FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene-rated by 5-FU treatment, because N-acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ-tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ-tocotrienol. Whereas 5-FU stimulated the expression of NF-E2-related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ-tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5-FU-induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2-dependent antioxidant genes, such as heme oxygenase-1 (HO-1) and quinone oxidoreductase-1 (NQO-1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ-tocotrienol could prevent 5-FU-induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes.

  14. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    International Nuclear Information System (INIS)

    Pueyo, Laurent; Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny; Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric; Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil; Monnier, John D.; Crepp, Justin; Parry, Ian; Beichman, Charles; Soummer, Rémi

    2012-01-01

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 μm interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A V = 8-12, with an effective temperature of ∼4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  15. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Pueyo, Laurent [Johns Hopkins University, Department of Physics and Astronomy, 366 Bloomberg Center 3400 N. Charles Street, Baltimore, MD 21218 (United States); Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil [American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 941 Dennison Building, 500 Church Street, Ann Arbor, MI 48109-1090 (United States); Crepp, Justin [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Parry, Ian [University of Cambridge, Institute of Astronomy, Madingley Road, Cambridge, CB3, OHA (United Kingdom); Beichman, Charles [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91225 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2012-09-20

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  16. 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

    International Nuclear Information System (INIS)

    Wang, Yongsheng; Gong, Changyang; Yang, Li; Wu, Qinjie; Shi, Shuai; Shi, Huashan; Qian, Zhiyong; Wei, Yuquan

    2010-01-01

    Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers

  17. Ezra Pound and Du Fu: Gazing at Mt. Tai

    Directory of Open Access Journals (Sweden)

    Kent Su

    2017-08-01

    Full Text Available Confined to a six-by-six-foot outdoor steel cage, Ezra Pound saw a series of mountain hills from a few miles to the east of Pisa. The poet compared one of these small 800-metre hills to the sacred Chinese Mt. Tai, which becomes the most common geographical name in The Pisan Cantos. Pound’s poetic summoning of this particular mountain is related to the fact that Mt. Tai is historically and culturally connected to the philosophy of Confucius, who personally ascended the mountain several times. Pound, as a devout Confucian disciple, closely follows the philosophical doctrines and attempts to mentally trace the footsteps of Confucius. This paper will argue how Pound’s poetic evocation of the mountain shares a striking similarity to an eighth-century Chinese poem called “Gazing at Mt. Tai,” which was written by the famous literatus - Du Fu 杜甫(712 – 770 . In spite of living in two completely different eras and countries, Pound’s and Du Fu’s reference to Mt. Tai demonstrates the confluence of their poetic spirits. Neither of them ascended mountain personally. They instead made use of their poetic imagination to follow the paths of Confucius and perceived the mountain as an earthly paradise, one which represents tranquillity and serenity away from the moral and physical corruption of the external world.

  18. The Effect of 5-FU and Radiation on A549 Cells In Vitro

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myung Za [Hanyang University College of Medicine, Seoul (Korea, Republic of); Chun, Ha Chong [Medical College of Virgina, Richmond (United States); Lee, Won Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1989-06-15

    Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it clonal specificity Monitored by changes in distribution of chromosome number were studies in A549 cell line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell was Seen in cells treated with 5-FU concentration of 0.47g/ml for 24 hr exposure. Cell survival carves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or 0.47g/ml of 5-FU treatment, and combined treatment of cloth were 77ne to examine the changes in ploidy and number of chromosome. Radiation combined with 5-FU enhanced growth inhibition of A549 cells. However, no evidence of synergetic effects in growth inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation(300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy, which were seen in cells treated with radiation. The cell treated with 5-FU and followed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy(93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.

  19. Near fatal 5-FU gut toxicity post surgery--remarkable effect of high-dose sucralfate.

    Science.gov (United States)

    Toh, James Wei Tatt; Morris, David; Chen, Zhuoran; Chen, Cindy

    2015-06-01

    The objective of this review article and case report was to investigate the effectiveness of high-dose sucralfate on severe life-threatening 5-fluorouracil (5-FU) gut toxicity, with reference to, but not limited to dihydropyrimidine dehydrogenase (DPD) deficiency. A search was conducted on PubMed from 1950 to July 2013 for original studies on 5-FU gut toxicity and sucralfate. Studies were limited to human trials and English language and all articles included in this study were assessed with the application of predetermined selection criteria. Each article was then reviewed independently by two reviewers. A case report from our own centre was included in this review. From 33 results, 6 manuscripts were identified including 4 randomized controlled trial. One trial evaluated the use of sucralfate to alleviate stomatitis in patients with 5-FU-based chemotherapy. The other three trials evaluated the role of sucralfate in radiation toxicity. There was one case report which showed gastroscopy confirmed normalization of severe dysplastic erosive gastroduodenitis attributed to hepatic arterial infusion of 5-FU following a 2-month course of sucralfate and cimetidine and one case series showing clinical and sigmoidoscopically demonstrated improvement in ulcerative colitis in majority of patients receiving sucralfate enemas. There was no current literature specifically focussed on the role of sucralfate in 5-FU gut toxicity. Our case report describes the clinical course and successful treatment with sucralfate of a patient with Pseudomyxoma peritonei (PMP) who experienced 5-FU gut toxicity resulting in life-threatening bleeding due to presumed DPD deficiency post intraperitoneal 5-FU administration. This review article showed a lack of literature concerning the use of sucralfate in 5-FU gut toxicity. In our patient's case, sucralfate had a crucial role in the management of near fatal 5-FU gut toxicity, and further evaluation is required.

  20. E-komercija un paterētāju aizsardzība

    OpenAIRE

    Mošenoka, Olga

    2013-01-01

    Bakalaura darba temats – E-komercija un patērētāju aizsardzība. Izstrādātais darbs sastāv no 70 lapaspusēm, 19 attēliem . Bakalaura darba mērķis: Izpētīt kas ir elektroniska komercija, kādas ir e-komercijas priekšrocības un trūkumi, kas ir e-komercijas dalībnieki, patērētāju aizsardzība. Izvirzītie darba uzdevumi: •noskaidrot kas ir e-bizness un e-komercija; •noskaidrot e-komercijas dalībniekus, priekšrocības, trūkumus; •iepazīties ar visveiksmīgākajiem e-komercijas piem...

  1. Teoria do juízo na lógica do conceito de Hegel

    Directory of Open Access Journals (Sweden)

    Christian Iber

    2017-02-01

    Full Text Available A Lógica de Hegel trata do pensar e de suas formas. A Lógica do Ser e da Essência descreve as formas insuficientes do pensar, ao passo que a Lógica do Conceito apresenta o autoconhecimento do pensar em sua verdade. Em sua Lógica, Hegel critica tanto a metafísica tradicional como a filosofia moderna, mas a crítica dele difere profundamente da filosofia analítica da linguagem e da teoria moderna da ciência. Na Lógica do Conceito, Hegel apresenta o conceito de um objeto através dos juízos, que nós proferimos sobre ele. O artigo tem por objetivo explicitar o sentido racional assim como o conteúdo crítico e produtivo da teoria hegeliana do juízo.

  2. Juó Bananére, o raté do modernismo paulista?

    Directory of Open Access Journals (Sweden)

    Elias Thomé Saliba

    1997-12-01

    Full Text Available This article aims to reconstruct part of the trajectory of the chronicler Juó Bananére, from São Paulo, since 1915, year which marked the beginning of Olavo Bilac's nationalist campaign. With ephemeral and circunstantial appearances in the press, Juó Bananére's good temper, with its linguistic anarquism, was always opportune in the context of the programatic nationalism which was characteristic of the years that preceded the modernism of 1922. In the beginning of the 1930's, with contributions to Aparício Aporelli's A Manha, and with the foundation of his own pasquim, Diário d'o Abax'o Piques, the chronicler contributed to reasserting the provoking - and impertinent - side of the culture of São Paulo's Belle Époque.

  3. Rotational Characterization of Hayabusa II Target Asteroid (162173) 1999 JU3

    OpenAIRE

    Moskovitz, Nicholas; Abe, Shinsuke; Pan, Kang-Shian; Osip, David; Pefkou, Dimitra; Melita, Mario; Elias, Mauro; Kitazato, Kohei; Bus, Schelte; DeMeo, Francesca; Binzel, Richard; Abell, Paul

    2013-01-01

    The Japanese Space Agency's Hayabusa II mission is scheduled to rendezvous with and return a sample from the near-Earth asteroid (162173) 1999 JU3. Previous visible-wavelength spectra of this object show significant variability across multiple epochs which could be the result of a compositionally heterogeneous surface. We present new visible and near-infrared spectra to demonstrate that thermally altered carbonaceous chondrites are plausible compositional analogs, however this is a tentative ...

  4. [Professor Xu Fu-song's traditional Chinese medicine protocols for male diseases: A descriptive analysis].

    Science.gov (United States)

    Liu, Cheng-yong; Xu, Fu-song

    2015-04-01

    To analyze the efficacy and medication principles of Professor Xu Fu-songs traditional Chinese medicine (TCM) protocols for male diseases. We reviewed and descriptively analyzed the unpublished complete medical records of 100 male cases treated by Professor Xu Fu-song with his TCM protocols from 1978 to 1992. The 100 cases involved 32 male diseases, most of which were difficult and complicated cases. The drug compliance was 95%. Each prescription was made up of 14 traditional Chinese drugs on average. The cure rate was 32% , and the effective rate was 85%. Professor Xu Fu-song advanced and proved some new theories and therapeutic methods. Professor Xu Fu-song's TCM protocols can be applied to a wide range of male diseases, mostly complicated, and are characterized by accurate differentiation of symptoms and signs, high drug compliance, and excellent therapeutic efficacy.

  5. Asynchronous Sensor fuSion for Improved Safety of air Traffic (ASSIST), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — SSCI proposes to develop, implement and test a collision detection system for unmanned aerial vehicles (UAV), referred to as the Asynchronous Sensor fuSion for...

  6. Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

    Science.gov (United States)

    Wang, Yixin; Li, Jianliang; Li, Yang; Fang, Lichun; Sun, Xiaolong; Chang, Shuang; Zhao, Peng; Cui, Zhizhong

    2016-06-01

    Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

  7. Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

    Directory of Open Access Journals (Sweden)

    Mei Peng

    Full Text Available Although 5-fluorouracil (5-Fu combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs, it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group and 92.37% in the 5-Fu+Act-D group (5-Fu group; these rates were not significantly different (P > 0.05. However, the incidence rates of myelosuppression (white blood cell decline, gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea, skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05. The results of this study may provide useful data for the clinical application of tegafur in GTN treatment.

  8. Characteristic patients with oral mucositis receiving 5-FU chemotherapy at Hasan Sadikin Hospital Bandung

    Directory of Open Access Journals (Sweden)

    Syarifah Fatimah

    2016-11-01

    Full Text Available Introduction: Oral mucositis is an inflammatory reaction of oral mucous membrane that often appears in cancer patients due to the chemotherapeutic agents, such as 5-fluorouracil (5-FU. The aim of this study was to describe the characteristic patients who receive 5-FU and had oral mucositis. Methods: This study was conducted on 41 patients with cancer receiving 5-FU chemotherapy at Dr Hasan Sadikin Hospital Bandung. The data was retrieved through interviews to find out patient’s characteristic; nutritional status examination by using body mass index measurement; and oral examination. Severity level was determined by using National Cancer Institute’s Common Toxicity Criteria scale, and the level of pain was measured by Numeric Pain Intensity Rating scale. Results: This research have shown 60,98% patient with cancer had received 5-FU chemotherapy treatment, and 44% with poor nutritional status (underweight. Oral mucositis was only found at non-keratinised mucous. The finding of this study was patients that receiving 5-FU chemotherapy treatment diagnosed with oral mucositis was on the 1st stadium (52% and the 2nd stadium (44% with the level of pain was on the mild level (48% and moderate level (32%.Conclusion: Oral mucositis was found on patients with cancer that received 5-FU chemotherapy with a variety of characteristics, nutritional statuses, locations, levels of severity and pain.

  9. Skolotāju apmierinātības ar darbu, stresa un pašefektivitātes sakarības skolotāju grupā

    OpenAIRE

    Radziņš, Rolands

    2018-01-01

    No skolotāju apmierinātības ar darbu, stresa pārvarēšanas un pašefektivitātes ir atkarīga ne tikai viena konkrēta darbinieka, bet visas izglītības iestādes skolotāju un personāla labizjūta un pedagoģiskā darba efektivitāte kopumā. Pētījuma „Skolotāju apmierinātības ar darbu, stresa un pašefektivitātes sakarības skolotāju grupā” mērķis, saskaņā ar pasūtījumu, bija noskaidrot skolotāju apmierinātību ar darbu, darba stresa un pašefektivitātes sakarības un izstrādāt atbalsta pasākumus un rekomend...

  10. Iedzīvotāju mobilitātes izpausmes Kārsavas pilsētā

    OpenAIRE

    Bleive, Jolanta

    2010-01-01

    Bakalaura darba „Iedzīvotāju mobilitātes izpausmes Kārsavas pilsētā” mērķis ir izanalizēt migrācijas procesu Kārsavas pilsētā. Iedzīvotāju mobilitāte ir jēdziens, ar ko tiek apzīmēta personu kustība vai pārvietošanās. Bakalaura darbā tiek aplūkota galvenokārt iedzīvotāju mobilitāte un tai raksturīgākās iezīmes Kārsavas pilsētā. Darbs tiek strukturēts divās daļās – teorētiskās studijas un Kārsavas pilsētas iedzīvotāju mobilitātes analīze. Pētījumā tiek apskatīti un raksturoti iedzīvotāju s...

  11. Utjecaj ambalaže na području selektivne kozmetike i parfema

    OpenAIRE

    Ferenčak, Maja

    2015-01-01

    Završni rad bavi se izgledom ambalaže proizvoda selektivne kozmetike i skupocjenih parfema kroz identitet određenog branda, i njegovog krajnjeg korisnika-tržišta odnosno ciljane skupine. Dizajn ambalaže često ima presudan utjecaj na konačan izgleda proizvoda pogotovo u području o kojem pišem u završnom radu. Ambalaža selektivne kozmetike mora biti luksuzna i elegantna kako bi opravdala svoj naziv i pokazala ono što je izdvaja od takozvane „mass“ kozmetike. Ključna zadaća samog ...

  12. Exploring the efficacy of an environmental health intervention in Ciudad Juárez, Mexico.

    Science.gov (United States)

    Hernández, Alma A; Grineski, Sara E

    2010-01-01

    This study explores the efficacy of an environmental health intervention in several poor colonias in Ciudad Juárez (Mexico). Parents of children with respiratory problems were given environment-friendly products intended to replace hazardous products used in the home, as well as information about environmental health. Parents were surveyed before and after to measure the effectiveness of the intervention and to gauge perceptions. There was a significant reduction in hazardous chemical use (eg, cleaning products and pesticides) and breathing problems. While the intervention focused on changing in-home behaviors, open-ended responses revealed that parents were most concerned about outdoor environmental conditions over which they had less control.

  13. TRENDI NA PODROČJU CELOVITIH INFORMACIJSKIH REŠITEV (ERP)

    OpenAIRE

    Bednjanič, Aljaž

    2012-01-01

    V diplomskem seminarju so predstavljeni trendi na področju rešitev ERP. Ponudniki rešitev ERP nenehno spreminjajo in dopolnjujejo svoje produkte ter jim dodajajo nove funkcionalnosti. Predstavljeni so naslednji trendi: x-ERP, zunanje izvajanje rešitev ERP, rešitev ERP kot storitev (SaaS ERP), ERP v oblaku in mobilni dostop. Zagotovo je najzanimivejša novost ERP v oblaku. Ta nudi številne prednosti, a obstaja veliko vprašanj, povezanih z varnostjo podatkov v oblaku. Pogledali smo, kako je z zu...

  14. Poziv: Duhovnost i san. San o oružju Franje Asiškoga

    OpenAIRE

    Balajić, Siniša

    2009-01-01

    San o oružju Franje Asiškoga doima se važnim elemenatom u proučavanju, ne toliko poziva Franje Asiškoga, koliko poziva uopće. Budući da se analizom i interpretacijom snova bave antropologija, psihologija, filozofija, teologija, itd., koncept razumijevanja ovoga sna uokviruje različita znanstvena (antropologija, psihologija) i teorijska načela (filozofija, teologija-duhovnost). Svjesni smo da proučavanje nečijega života, a pogotovo proučavanje nečijih snova, nije nimalo la...

  15. Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma.

    Science.gov (United States)

    Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat; Khadem, Mostafa

    2012-09-01

    The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), containing LB conjugate, lecithin, glyceryl monostearate, oil [oleic acid (OA) or Labrafac 5 or 10%], and 5-FU, were dissolved in alcohol/acetone, the oil phase was added to the aqueous phase containing Tween 80 or Solutol(®) HS15 (0.25 or 0.5%), and NLCs were prepared by an emulsification-solvent diffusion method. Physical properties and drug release were studied in NLCs. The thiazolyl blue tetrazolium bromide assay was used to study the cytotoxicity of NLCs on HepG(2) cells, and the cellular uptake of NLCs was determined by flow cytometry. Fourier transform infrared spectroscopy and (1)H-NMR spectra confirmed the successful conjugation of LB and SA. The optimized NLCs consisted of 0.5% Solutol HS15 and 10% OA oil. The particle size of these nanoparticles was 139.2 nm, with a zeta potential of -18 mV, loading efficiency of 34.2%, release efficiency after 2 hours of the release test was 72.6%, and crystallinity was 0.63%. The galactosylated NLCs of 5-FU were cytotoxic on the HepG(2) cell line in a half concentration of 5-FU and seems promising in reducing 5-FU dose in HCC.

  16. Overview of the Fusion Z-Pinch Experiment FuZE

    Science.gov (United States)

    Weber, T. R.; Shumlak, U.; Nelson, B. A.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Team

    2016-10-01

    Previously, the ZaP device, at the University of Washington, demonstrated sheared flow stabilized (SFS) Z-pinch plasmas. Instabilities that have historically plagued Z-pinch plasma confinement were mitigated using sheared flows generated from a coaxial plasma gun of the Marshall type. Based on these results, a new SFS Z-pinch experiment, the Fusion Z-pinch Experiment (FuZE), has been constructed. FuZE is designed to investigate the scaling of SFS Z-pinch plasmas towards fusion conditions. The experiment will be supported by high fidelity physics modeling using kinetic and fluid simulations. Initial plans are in place for a pulsed fusion reactor following the results of FuZE. Notably, the design relies on proven commercial technologies, including a modest discharge current (1.5 MA) and voltage (40 kV), and liquid metal electrodes. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

  17. Treating malfunction filtering bleb with repeated needling combined with adjunctive 5-FU after glaucoma filtration surgery

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2013-07-01

    Full Text Available AIM: To evaluate the therapeutic efficacy of a repeated bleb needling technique combined with subconjunctival injection of 5-FU in eyes with previous glaucoma surgery that had malfunctional filtering blebs. METHODS: A retrospective review of 34 consecutive patients(34 eyesof repeated bleb needling combined with subconjunctival injection of 5-FU in eyes, which had malfunctional filtering blebs after previous glaucoma surgery in our hospital from March 2009 to February 2013 was performed. The intraocular pressures(IOP, shapes of filtering blebs and complications after surgery were analyzed. RESULTS: There was significant reduction of mean IOP from 35.51mmHg to 14.43mmHg(PCONCLUSION: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to treat malfunctional filtering blebs after previous glaucoma surgery.

  18. Evolutionism through Chinese Eyes: Yan Fu, Ma Junwu and Their translations of Darwinian Evolutionism

    Directory of Open Access Journals (Sweden)

    Tsing-song Vincent Shen

    2015-04-01

    Full Text Available The huge impact that Darwinian Evolutionism has effected over Chinese intellectuals through Yan Fu's translation of Huxley's "Evolution and Ethics" into the Tianyanlun, is in fact based on Chinese traditional worldview on the one hand and the novel ideas it brings to the Chinese mind facing the challenge of transition. However, Yan Fu's translation is not as scientific as it should be when dealing with Huxley's discourse. Ma Junwu's translation of Darwin's "On the Origin of Species" attempts to be more scientific, in an effort to supply exact scientific terms and discourse in Chinese. However, at the end it is social Darwinism that has won the mind of the Chinese people. This paper analyses the ideas in Chinese past that leads to Chinese perception of Darwimism evolutionism and examines the ways it has been translated by Yan Fu and Ma Junwu.  

  19. Transfrontera Crimes: Representations of the Juárez Femicides in Recent Fictional and Non-Fictional Accounts

    Directory of Open Access Journals (Sweden)

    Marietta Messmer

    2012-05-01

    Full Text Available In her article, Marrietta Messmer discusses the representation of the Juárez femicides and their traumatizing effects on the Juárez/El Paso community in four recently published accounts: Teresa Rodriguez's journalistic account The Daughters of Juarez (2007, the documentary Señorita Extraviada (2001 directed by Lourdes Portillo, the feature film Bordertown (2006, directed by Gregory Nava, and Alicia Gaspar de Alba's mystery novel Desert Blood: The Juárez Murders (2005. More specifically, she analyzes the degree to which these sources regard the femicides not merely as a Mexican problem but as a structural and highly significant transborder issue that has its roots in the region's current political and economic developments, as well as its pervasive social and cultural changes.

  20. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma

    International Nuclear Information System (INIS)

    Schroeder, M.; Westerhausen, M.; Makoski, H.B.; Sesterhenn, K.; Schroeder, R.

    1997-01-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m 2 as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m 2 /d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [de

  1. Embers of society: Firelight talk among the Ju/'hoansi Bushmen.

    Science.gov (United States)

    Wiessner, Polly W

    2014-09-30

    Much attention has been focused on control of fire in human evolution and the impact of cooking on anatomy, social, and residential arrangements. However, little is known about what transpired when firelight extended the day, creating effective time for social activities that did not conflict with productive time for subsistence activities. Comparison of 174 day and nighttime conversations among the Ju/'hoan (!Kung) Bushmen of southern Africa, supplemented by 68 translated texts, suggests that day talk centers on economic matters and gossip to regulate social relations. Night activities steer away from tensions of the day to singing, dancing, religious ceremonies, and enthralling stories, often about known people. Such stories describe the workings of entire institutions in a small-scale society with little formal teaching. Night talk plays an important role in evoking higher orders of theory of mind via the imagination, conveying attributes of people in broad networks (virtual communities), and transmitting the "big picture" of cultural institutions that generate regularity of behavior, cooperation, and trust at the regional level. Findings from the Ju/'hoan are compared with other hunter-gatherer societies and related to the widespread human use of firelight for intimate conversation and our appetite for evening stories. The question is raised as to what happens when economically unproductive firelit time is turned to productive time by artificial lighting.

  2. A survey of ectoparasite infestations in stray dogs of Gwang-ju City, Republic of Korea.

    Science.gov (United States)

    Chee, Jeong Hyun; Kwon, Jung Kee; Cho, Ho Seong; Cho, Kyoung Oh; Lee, Yu Jin; Abd El-Aty, A M; Abdel-Aty, A M; Shin, Sung Shik

    2008-03-01

    This study was designed to investigate the incidence of ectoparasite infestation among stray dogs in Gwang-ju City, Republic of Korea. A total of 103 stray dogs collected in the Animal Shelter of Gwang-ju City from November 2003 to August 2005 were investigated in this study. Ectoparasites of one or more genera were detected in 45.6% (47 / 103) of the dogs examined for dermatologic lesions and/or skin scrapings (from 3-5 affected areas). Otodectes cynotis was found to be the most frequent parasite (22.3%, 23 / 103), followed by Sarcoptes scabiei var canis (19.4%, 20 / 103), Ctenocephalides canis (6.8%, 7 / 103), Demodex canis (4.9%, 5 / 103), and Trichodectes canis (1.0%, 1 / 103). Monospecific infestation was found in 83.0% (39 / 47) of the affected dogs, whereas concurrent infestations with 2 or more ectoparasites per animal were found in 17.0% (8 / 47) of the affected dogs. Trichodectes canis is reported for the first time in the Republic of Korea. Dogs less than 1 yr old were more heavily infected than other age groups (66.7%), and small-sized dogs of less than 3 kg body weight were more heavily infected than larger dogs (41.7%).

  3. Avatares y desafíos del Instituto Juárez de Tabasco

    Directory of Open Access Journals (Sweden)

    Judith Pérez Castro

    2015-01-01

    Full Text Available El propósito de este trabajo es hacer un análisis de las circunstancias que rodearon la fundación y el desarrollo del Instituto Juárez de Tabasco. El artículo intenta mostrar la compleja situación que enfrentó este establecimiento educativo desde su creación en 1879 hasta las primeras décadas del siglo XX y el impacto que esto tuvo tanto en su oferta educativa como en su planta académica. Las principales variables que contextualizaron el desarrollo institucional fueron la difícil situación financiera, el cierre y apertura de sus carreras, la insuficiencia de matrícula, la débil organización de su cuerpo de profesores y la inestabilidad política estatal. A pesar de esto, el Instituto Juárez logra mantenerse y consolidarse como la principal opción educativa a nivel preparatoria y profesional en la entidad, hecho que aunado a un nuevo proceso de reforma hacen posible su ascenso como universidad hacia finales de los años cincuenta.

  4. los caminos globales de Ciudad Juárez, Chihuahua-El Paso,Texas

    Directory of Open Access Journals (Sweden)

    Kathleen Staudt

    2006-01-01

    Full Text Available En este artículo se abordan temas selectos de políticas públicas, que dividen y unen a las mujeres en la frontera México-Estados Unidos, concentrados en el área metropolitana de Ciudad Juárez-El Paso, que conforma una "economía interdependiente", con una población superior a dos millones de personas, cuya mayoría comparte una herencia mexicana. De esta forma, se analiza una perspectiva compleja: la economía global en la que las maquiladoras de Ciudad Juárez están a la vanguardia; los cambios ideológicos de derecha en los gobiernos de México y Estados Unidos; con gobiernos divididos en filiación partidista así como en materia del federalismo, éste practicado en forma diferente por ambos, y en los cuales las voces de las mujeres tienen poca notoriedad. Sin embargo, ellas se organizan en grupos que representan sus intereses, aunque sus voces han sido marginadas en la sociedad y en la acción legislativa. Existen pocas organizaciones binacionales de mujeres, con algunas excepciones en los aspectos de salud y violencia.

  5. Integrated river basin management of Južna Morava River

    Directory of Open Access Journals (Sweden)

    Borisavljević Ana

    2012-01-01

    Full Text Available In the last decade in particular, Serbia encountered the problems of drinking water supply, which influenced the perception of professional public about the water crisis but also started more intensive work on water resource perseverance as well as the implementation of European Water Directive. One of the main demands of the Directive focuses on integrated river basin management (IRBM, which is a complex and a large task. The need to collect data on water quality and quantity, specific and key issues of water management in Južna Morava river basin, pressures on river ecosystem, flood risks and erosion problems, cross-border issues, socioeconomic processes, agricultural development as well as protected areas, and also to give the measures for solving problems and pressures recognized in the basin, is undisputable. This paper focuses on detailed analysis of specific pressures on river ecosystem and composition of recommendations for integrated management of Južna Morava river basin as cross-border river basin, taking into the account European experiences in IRBM. [Projekat Ministarstva nauke Republike Srbije, br. 43007: Istraživanje klimatskih promena na životnu sredinu - praćenje uticaja, adaptacija i ublažavanje, podprojekat br. 9: Učestalost bujičnih poplava, degradacija zemljišta i voda kao posledica globalnih promena

  6. Identificación de Chlamydophila abortus en un aborto ovino en Almoloya de Juárez, México

    OpenAIRE

    Edgardo Soriano-Vargas; Celene Salgado-Miranda; Juan Manuel Jiménez-Estrada; Marcela López-Hurtado; Fernando M. Guerra-Infante; Marcos R. Escobedo-Guerra

    2011-01-01

    ResumenSe identificó la presencia de Chlamydophila abortus en un aborto ovino procedente de Almoloya de Juárez, México.SummaryChlamydophila abortus was identified in an ovine aborted fetus from Almoloya de Juárez, México

  7. Evaluation of 5-FU pharmacokinetics in cancer patients with DPD deficiency using a Bayesian limited sampling strategy

    NARCIS (Netherlands)

    Van Kuilenburg, A.; Hausler, P.; Schalhorn, A.; Tanck, M.; Proost, J.H.; Terborg, C.; Behnke, D.; Schwabe, W.; Jabschinsky, K.; Maring, J.G.

    Aims: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. The main purpose of this study was to develop a limited sampling strategy to evaluate the pharmacokinetics of 5FU and to detect

  8. Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid

    NARCIS (Netherlands)

    Jansman, FGA; Coenen, JLLM; De Graaf, JC; Tobi, H; Sleijfer, DT; Brouwers, JRBJ

    2002-01-01

    Background: Dose adaptation based on pharmacokinetic parameters has been shown to decrease toxicity of some 5-fluorouracil(5-FU)-based continuous infusion regimens. Patients and Methods: In the present study the relationship between 5-FU pharmacokinetics in plasma and in saliva, and toxicity was

  9. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Jensen, S; Vainer, B

    2009-01-01

    Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical...

  10. [Mining analysis on composition and medication of menstruation prescriptions in Fu Qingzhu's Obstetrics and Gynecology].

    Science.gov (United States)

    Zhu, Jia-qing; Che, Yu-xia

    2015-04-01

    In this paper, menstruation prescriptions were selected from "Fu Qingzhu's Obstetrics and Gynecology" and analyzed by using GRI algorithm, correlation analysis, hierarchical clustering method through SPSS, Clementine and traditional Chinese medicine (TCM) inheritance auxiliary systems, in order to screen out 15 menopathy prescriptions, which involve 45 traditional Chinese medicine herbs. In the study, blood-tonifying and qi-tonifying herbs were found to be frequent in the prescriptions. The most frequent single herb was white paeony root, accounting for 9.6% in the total number of prescriptions; The most frequent herb pairs were white paeony root-radix rehmanniae preparata and paeony root-angelica sinensis. Among Fu Shan's menopathy prescriptions, 61 herbal pairs showed a correlation coefficient exceeding 0.05, which evolved into 16 pairs of core combinations. The analysis showed that menopathy prescriptions in volume 1 of "Fu Qingzhu's Obstetrics and Gynecology" focused on tonic traditional Chinese medicines involving liver, spleen and kidney and were adjusted according to changes in qi, blood, cold, hot and wet, which could provide a specific reference for further studies on Fu Shan's academic thoughts and traditional Chinese medicine clinical treatment of menopathy.

  11. The FU Orionis outburst as a thermal accretion event: Observational constraints for protostellar disk models

    Science.gov (United States)

    Bell, K. R.; Lin, D. N. C.; Hartmann, L. W.; Kenyon, S. J.

    1995-01-01

    The results of the time-dependent disk models developed in Bell & Lin are compared with observed properties of FU Orionis variables. Specific models are fit to the light curves of Fu Ori, V1515 Cyg, and V1057 Cyg. The slow risetime of V1515 Cyg can be matched by a self-regulated outburst model. The rapid risetimes of FU Ori and V1057 Cyg can be fitted with the application of modest perturbations to the disk surface density. Model disks display spectral features characteristic of observed objects. The color evolution of V1057 Cyg is naturally explained if mass flux drops in the inner disk (r less than 1/4 AU) while remaining steady in the outer disk. The decrease in optical line width (rotational velocity) observed during the decay of V1057 Cyg may be accounted for by an outward-propagating ionization front. We predict that before final decay to the quiescent phase, short-wavelength line widths (lambda less than 1.5 microns) will again increase. It is suggested that FU Orionis outbursts primarily occur to systems during the embedded phase with ages less than several times 10(exp 5) yr.

  12. The cardiovascular responses of male subjects to kung fu techniques. Expert/novice paradigm.

    Science.gov (United States)

    Jones, M A; Unnithan, V B

    1998-12-01

    The primary aim was to assess cardiovascular responses of expert and novice subjects to kung fu techniques. It was hypothesised that experienced subjects would demonstrate improved economy of movement during the techniques, evidenced by reduced exercise intensity. a comparative design was established utilising two groups; experienced (group E), and novice (group N). the experimentation took place under laboratory conditions, but was designed to maximise external validity. the only preselection variables were regular attendance at training and experience. Nine experienced males (group E, exp 9.5 +/- 5.2 yrs) and nine novice males (group N, exp 1.2 +/- 0.1 yrs) participated. The only exclusion guidelines were contraindications to participate within a maximal test, no subjects were excluded upon this basis. N/A. each subject participated in three kung fu protocols (forms, kicking and punching). Each protocol, randomly allocated, consisted of ten work (30 sec) and ten rest periods (30 sec). MEASURES taken during the protocols were heart rate (HR) and oxygen consumption (VO2). These were expressed as a percentage of maximal values to reflect exercise intensity. During both the form protocol and punching protocol group E were found to be working at a significantly (p kung fu techniques differ depending upon experience level. It is difficult to directly relate this to improved economy since work output could not be accurately quantified. It was also found that kung fu protocols elicited exercise intensity into the cardiovascular training zone.

  13. FuGeF: A Resource Bound Secure Forwarding Protocol for Wireless Sensor Networks.

    Science.gov (United States)

    Umar, Idris Abubakar; Mohd Hanapi, Zurina; Sali, A; Zulkarnain, Zuriati A

    2016-06-22

    Resource bound security solutions have facilitated the mitigation of spatio-temporal attacks by altering protocol semantics to provide minimal security while maintaining an acceptable level of performance. The Dynamic Window Secured Implicit Geographic Forwarding (DWSIGF) routing protocol for Wireless Sensor Network (WSN) has been proposed to achieve a minimal selection of malicious nodes by introducing a dynamic collection window period to the protocol's semantics. However, its selection scheme suffers substantial packet losses due to the utilization of a single distance based parameter for node selection. In this paper, we propose a Fuzzy-based Geographic Forwarding protocol (FuGeF) to minimize packet loss, while maintaining performance. The FuGeF utilizes a new form of dynamism and introduces three selection parameters: remaining energy, connectivity cost, and progressive distance, as well as a Fuzzy Logic System (FLS) for node selection. These introduced mechanisms ensure the appropriate selection of a non-malicious node. Extensive simulation experiments have been conducted to evaluate the performance of the proposed FuGeF protocol as compared to DWSIGF variants. The simulation results show that the proposed FuGeF outperforms the two DWSIGF variants (DWSIGF-P and DWSIGF-R) in terms of packet delivery.

  14. "Welch Schauspiel! Aber ach! ein Schauspiel : Fußball und Theater

    OpenAIRE

    Thiergen, Peter

    2009-01-01

    Der Essay zeigt, wie eng Fußball und Schauspiel/Theater/Drama zusammenhängen. Dabei wird nicht nur einer Vielzahl von sprachlichen und insbesondere metaphorischen Entsprechungen nachgespürt, in denen sich die beiden Publikumsereignisse wechselseitig interpretieren, sondern auch gezeigt, auf welchen medialen Grundlagen, Erfahrungen und Rezeptionsdispositionen diese Entsprechungen beruhen.

  15. Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU

    DEFF Research Database (Denmark)

    Glavas-Dodov,, Marija; Steffansen, Bente; Srcarevska, Maja

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these......We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential......-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed...... by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region....

  16. Una poética de la memoria: la poesía de Rafael Juárez

    NARCIS (Netherlands)

    Valdivia, P.

    2010-01-01

    In this essay, the intellectual and literary foundations of Rafael Juárez’s poetic discourse are studied in depth. Such assessment is specifically carried out taking as an example his poetry collection entitled Aulaga. From the theoretical framework provided by Paul Ricoeur in his works about the

  17. Teadlased: Juštšenkole anti väga puhast mürki

    Index Scriptorium Estoniae

    2009-01-01

    Suurbritannia ajakiri Lancet väidab, et dioksiin, mis põhjustas Ukraina presidendile Viktor Juštšenkole 2004. aastal tõsise mürgituse, oli nii puhas, et pidi pärinema otse laboratooriumist, kuna loodusest ei saa puhast dioksiini

  18. Problems of spatial-functional organization of Južno Pomoravlje region’s network of settlements

    Directory of Open Access Journals (Sweden)

    Krunić Nikola

    2009-01-01

    Full Text Available During the elaboration of the Regional spatial plan of the municipalities of Južno Pomoravlje (Region Južno Pomoravlje a special attention was paid to its network of settlements. Demographical and functional determinants of this network were analyzed based on the relevant theoretical-methodological concepts and qualitative-quantitative indicators. Settlement network of Južno Pomoravlje was considered as a subsystem of the Republic of Serbia’s settlements’ system. Correlation and causality between processes of spatial and socio-economic migration of population and functional transformation of settlements have been highlighted, which caused differentiation of the Region’s municipalities to: urban cores - peri-urban rings - suburban more or less urbanized villages and rural surroundings. Models of decentralized concentration and micro-developing nuclei are proposed as instruments for decentralization of the Region or its municipalities. Based on the level of spatial-functional integration of settlements, regional as well as municipal and micro-functional - micro-regional structures have been identified. This paper gives conceptual and strategic proposals of spatial-functional organization of Južno Pomoravlje, which are based on settlements’ determinants. Authors suggest that functional premises define determinants for the Regional spatial plan and steer the sectoral and strategic decisions.

  19. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

    Science.gov (United States)

    Ribeiro, Susana Barbosa; de Araújo, Aurigena Antunes; Araújo Júnior, Raimundo Fernandes de; Brito, Gerly Anne de Castro; Leitão, Renata Carvalho; Barbosa, Maisie Mitchele; Garcia, Vinicius Barreto; Medeiros, Aldo Cunha; Medeiros, Caroline Addison Carvalho Xavier de

    2017-01-01

    Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX) on OM induced by 5-fluorouracil (5-FU) in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT) on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg). Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR). DEX (0.5 or 1 mg/kg) reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg) reduced the cytokine levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and macrophage migration inhibitory factor (MIF). DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg) increased interleukin-1 receptor-associated kinase 3 (IRAK-M), glucocorticoid-induced leucine zipper (GILZ), and mitogen-activated protein kinase (MKP1) gene expression and reduced NFκB p65 and serine threonine kinase (AKt) gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

  20. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

    Directory of Open Access Journals (Sweden)

    Susana Barbosa Ribeiro

    Full Text Available Oral mucositis (OM is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX on OM induced by 5-fluorouracil (5-FU in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg. Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR. DEX (0.5 or 1 mg/kg reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg reduced the cytokine levels of tumor necrosis factor (TNF-α, interleukin (IL-1β, and macrophage migration inhibitory factor (MIF. DEX (1 mg/kg also reduced the immunoexpression of cyclooxygenase (COX-2, matrix metalloproteinase (MMP-2, transforming growth factor (TGF-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg increased interleukin-1 receptor-associated kinase 3 (IRAK-M, glucocorticoid-induced leucine zipper (GILZ, and mitogen-activated protein kinase (MKP1 gene expression and reduced NFκB p65 and serine threonine kinase (AKt gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

  1. Impactos de la maquila en el medio ambiente de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Centro de Estudios Regionales y Comunicación Alternativa (CERCA

    2009-01-01

    Full Text Available En el presente trabajo analizamos, de manera general, los cambios que ha generado el proyecto maquilador en Ciudad Juárez. Primero observamos su efecto sobre el crecimiento de la mancha urbana, la dotación de servicios, etcétera, su repercusión en el medio ambiente y las condiciones de vida de la población juarense. Nos planteamos, además, ubicar los principales problemas causados por el desarrollo de la industria maquiladora, particularmente en lo relativo a los desechos tóxicos y nucleares, así como apuntar la tendencia del proyecto económico-urbano que ésta ha impuesto en nuestra ciudad, para concluir con una breve presentación de las reacciones populares y algunas propuestas ante el problema. Asimismo, exponemos los problemas de contaminación que resultan de otras actividades no vinculadas a la industria maquiladora.

  2. Teoria do juízo na lógica do conceito de Hegel

    OpenAIRE

    Christian Iber; Federico Orsini; Lauro Stoll Nardi; Agemir Bavaresco

    2017-01-01

    A Lógica de Hegel trata do pensar e de suas formas. A Lógica do Ser e da Essência descreve as formas insuficientes do pensar, ao passo que a Lógica do Conceito apresenta o autoconhecimento do pensar em sua verdade. Em sua Lógica, Hegel critica tanto a metafísica tradicional como a filosofia moderna, mas a crítica dele difere profundamente da filosofia analítica da linguagem e da teoria moderna da ciência. Na Lógica do Conceito, Hegel apresenta o conceito de um objeto através dos juízos, que n...

  3. Social acceptability urban form and sustainability in urban neighborhoods in Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Claudia Gabriela Vargas Fernández

    2016-11-01

    Full Text Available In the field of urban planning, questioning around sustainability and the possibility of sustainable urban planning has led to a new set of approaches and discussions that impact studies on urban form and sustainable livelihoods. This approach characterized the work presented by Mike Jenks and Colin Jones (2010, Dimensions of the Sustainable City, where a set of variables are presented about urban sustainability from the neighbourhood level of analysis. In that sense, this article proposes the analysis of three social housing neighborhoods in Ciudad Juárez, Chihuahua, México, integrating aspects of urban form and social acceptability, in order to understand the relationship between the physical and sociocultural dimensions of the concept of urban sustainability.

  4. Street Art at the Border: Representations of Violence and Death in Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Diana Alejandra SILVA LONDOÑO

    2016-01-01

    Full Text Available El objetivo de este artículo es realizar una lectura interpretativa de las tramas de sentido de la violencia y la muerte violenta en Ciudad Juárez, a partir de su representación en el arte urbano. Por medio de entrevistas en profundidad, observación participante, recorridos urbanos y regis - tro fotográf ico de la producción artística de los colectivos de arte urbano fronterizo se explora cómo las/os jóvenes se conciben a sí mismas/os, perciben su experiencia biográf ica y cuáles son sus márgenes de agencia desde las prácticas artísticas en contextos de violencia.

  5. Ciudad Juárez en los sesenta: la estructura urbana en transición

    Directory of Open Access Journals (Sweden)

    Luis Enrique Gutiérrez Casas

    2009-01-01

    Full Text Available El presente trabajo está estructurado de tal forma que puedan cubrirse, de manera general, los distintos aspectos que consideramos explican el problema de la vivienda en Ciudad Juárez. En la primera parte planteamos el problema de la vivienda desde varios aspectos, déficit, bajos salarios y pérdida del poder adquisitivo de los trabajadores, fluctuación del mercado inmobiliario, crecimiento poblacional, cambios en la composición del mercado laboral, flujos migratorios, políticas económicas y de vivienda. En la segunda parte centramos nuestro análisis en los AHI. Sus rasgos principales son las formas irregulares de apropiación del suelo urbano, la autoconstrucción y la introducción ilegal de servicios públicos, entre otros.

  6. residenciales de madres sin cónyuge en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Claudia Zamorano Villarreal

    2006-01-01

    Full Text Available Se abordarán los itinerarios y las prácticas residenciales de madres sin cónyuge en Ciudad Juárez, ese punto de convergencia de inmigrantes nacionales y capitales internacionales y ahora, una de las más importantes ciudades maquiladoras del país. A partir de 51 historias de vida con trabajadoras de esta industria, se comparan los itinerarios residenciales de familias monoparentales con los de familias biparentales. Esta comparación permite ver las desventajas de las primeras para ingresar al mercado de la vivienda, que no se explican únicamente por factores de orden económico, sino también moral y práctico.

  7. Homicidio masculino en Ciudad Juárez. Costos de las masculinidades subordinadas

    Directory of Open Access Journals (Sweden)

    Salvador Cruz

    2011-01-01

    Full Text Available El homicidio masculino agudizado en Ciudad Juárez en los años 2008 y 2009, con casi cuatro mil asesinatos, constituye la expresión más evidente de la violencia urbana. Dicha violencia ha tomado rostro en hombres, en su mayoría jóvenes y marginados. Los datos muestran un comportamiento del homicidio doloso asimilado a significados relacionados con la masculinidad más tradicional, cuyo costo recae en la vida misma. Se observa a través de los escenarios, los horarios en que ocurren los eventos y las formas de ejecución, que esta práctica delictiva puede ser comprendida como una actividad masculina que explota una subjetividad proclive a la violencia y que reproduce las asimetrías de género y significados asociados a la dicotomía masculino-femenino.

  8. A study of Radon-Concentration Distribution in Buildings in Gyeong-ju

    Energy Technology Data Exchange (ETDEWEB)

    Park, C. H.; Jang, S. Y.; Jung, O. J.; Moon, J. H. [Dongguk University, Gyeongju (Korea, Republic of)

    2010-10-15

    Radon({sup 222}Rn) gas is the natural radiation generated by radioactive decay of uranium({sup 238}U) nuclide. The radon which exists in ground flows into the inside by the atmospheric temperature, the differential-pressure or a gap of building underground and a ejection by a drywall with a phosphoric In Korea, Korean Institute of Nuclear Safety had been studied about the inside-radon radioactivity investigation over the nation. In the area around the nuclear power plant, it is possible to exist both of a radioactivity nuclide and a natural. Therefore it is necessary to investigate the radon radioactivity in surrounding area of nuclear power plants. In this study, it is purpose to develop the method of establishing the on-line monitoring system to minimize the radiological effect due to radon gas, based on the real state of radon exposure in Gyeong-ju surrounding Nuclear Power Plant

  9. Norm enforcement among the Ju/'hoansi Bushmen : A case of strong reciprocity?

    Science.gov (United States)

    Wiessner, Polly

    2005-06-01

    The concept of cooperative communities that enforce norm conformity through reward, as well as shaming, ridicule, and ostracism, has been central to anthropology since the work of Durkheim. Prevailing approaches from evolutionary theory explain the willingness to exert sanctions to enforce norms as self-interested behavior, while recent experimental studies suggest that altruistic rewarding and punishing-"strong reciprocity"-play an important role in promoting cooperation. This paper will use data from 308 conversations among the Ju/'hoansi (!Kung) Bushmen (a) to examine the dynamics of norm enforcement, (b) to evaluate the costs of punishment in a forager society and understand how they are reduced, and (c) to determine whether hypotheses that center on individual self-interest provide sufficient explanations for bearing the costs of norm enforcement, or whether there is evidence for strong reciprocity.

  10. Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections.

    Science.gov (United States)

    Li, Anyuan; Xie, Yanying; Qi, Fanghua; Li, Jie; Wang, Peng; Xu, Shulan; Zhao, Lin

    2009-08-01

    Yi-Fu-Qing granule is a traditional Chinese medicine for the treatment of acute respiratory tract infections. The present study sought to investigate the anti-virus effects of Yi-Fu-Qing granule on acute respiratory infections with respiratory syncytial virus (RSV) and human adenoviruses type 3 (Ad3). The cytotoxicity of Yi-Fu-Qing granule was evaluated by the neutral red assay on HeLa cells. The antiviral effect of Yi-Fu-Qing granule was tested by observing the cytopathogenic effect (CPE) with a compound mixture of Isatis leaf as the positive control drug. The results indicated that the highest non-toxicity concentration of Yi-Fu-Qing granule on Hela cells was 1:100. The CPE reduction assay showed that Yi-Fu-Qing granule inhibited RSV and Ad3 replication at a concentration of 1:100. Thus, Yi-Fu-Qing granule may have a significant antivirus effect on acute respiratory tract infections with RSV and Ad3 infections and this could prove useful for further antivirus research on acute respiratory tract infections.

  11. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.

    Science.gov (United States)

    Tukachinsky, Hanna; Lopez, Lyle V; Salic, Adrian

    2010-10-18

    In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional effectors of the pathway. In the absence of signaling, Gli proteins are inhibited by the cytoplasmic protein Suppressor of Fused (SuFu). It is unclear how Hh activates Gli and whether it directly regulates SuFu. We find that Hh stimulation quickly recruits endogenous SuFu-Gli complexes to cilia, suggesting a model in which Smo activates Gli by relieving inhibition by SuFu. In support of this model, we find that Hh causes rapid dissociation of the SuFu-Gli complex, thus allowing Gli to enter the nucleus and activate transcription. Activation of protein kinase A (PKA), an inhibitor of Hh signaling, blocks ciliary localization of SuFu-Gli complexes, which in turn prevents their dissociation by signaling. Our results support a simple mechanism in which Hh signals at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA.

  12. Avaliação da Composição Centesimal, Mineral e Teor de Antocianinas da Polpa de Juçaí (Euterpe edulis Martius)

    OpenAIRE

    Leilson de Oliveira Ribeiro; Marisa Fernandes Mendes; Cristiane de Souza Siqueira Pereira

    2015-01-01

    A polpa de juçaí, fruto da palmeira juçara (Euterpe edulis Martius) encontrada nas áreas da Mata Atlântica e a polpa de açaí, fruto da palmeira juçara (Euterpe oleracea Martius) cultivado na Floresta Amazônica, foram caracterizadas obtendo assim sua composição centesimal, mineral e também seu teor de antocianinas. Com os resultados obtidos foi possível fazer um estudo comparativo da concentração de antocianinas das duas polpas congeladas e verificar a importância do consumo destes alimentos, ...

  13. Pre-operative combined 5-FU, low dose leucovorin, and sequential radiation therapy for unresectable rectal cancer

    International Nuclear Information System (INIS)

    Minsky, B.D.; Cohen, A.M.; Kemeny, N.; Enker, W.E.; Kelsen, D.P.; Schwartz, G.; Saltz, L.; Dougherty, J.; Frankel, J.; Wiseberg, J.

    1993-01-01

    The authors performed a Phase 1 trial to determine the maximum tolerated dose of combined pre-operative radiation (5040 cGy) and 2 cycles (bolus daily x 5) of 5-FU and low dose LV (20 mg/m2), followed by surgery and 10 cycles of post-operative LV/5-FU in patients with unresectable primary or recurrent rectal cancer. Twelve patients were entered. The initial dose of 5-FU was 325 mg/m2. 5-FU was to be escalated while the LV remained constant at 20 mg/m2. Chemotherapy began on day 1 and radiation on day 8. The post-operative chemotherapy was not dose escalated; 5-FU: 425 mg/m2 and LV: 20 mg/m2. The median follow-up was 14 months (7--16 months). Following pre-operative therapy, the resectability rate with negative margins was 91% and the pathologic complete response rate was 9%. For the combined modality segment (preoperative) the incidence of any grade 3+ toxicity was diarrhea: 17%, dysuria: 8%, mucositis: 8%, and erythema: 8%. The median nadir counts were WBC: 3.1, HGB: 8.8, and PLT: 153000. The maximum tolerated dose of 5-FU for pre-operative combined LV/5-FU/RT was 325 mg/m2 with no escalation possible. Therefore, the recommended dose was less than 325 mg/m2. Since adequate doses of 5-FU to treat systemic disease could not be delivered until at least 3 months (cycle 3) following the start of therapy, the authors do not recommend that this 5-FU, low dose LV, and sequential radiation therapy regimen be used as presently designed. However, given the 91% resectability rate they remain encouraged with this approach. 31 refs., 1 fig., 2 tabs

  14. Tai Chi and Kung-Fu practice maintains physical performance but not vascular health in young versus old participants.

    Science.gov (United States)

    McAnulty, Steven; McAnulty, Lisa; Collier, Scott; Souza-Junior, Tacito P; McBride, Jeffrey

    2016-01-01

    Kung-Fu and Tai Chi along with other martial arts are gaining popularity but studies examining the benefits of martial arts on physical fitness, vascular health, nutrition, and psychological wellness are limited. Aging is associated with declines in these health components. The objectives of this study were to examine whether Tai Chi and Kung-Fu training would maintain physical fitness, vascular health, and psychological wellness components on older versus younger practitioners. Seventeen subjects were recruited and divided into Young (age Kung-Fu maintains physical fitness in older compared to younger practitioners. However, age associated changes in cardiovascular stiffness, systolic blood pressure, and pain were not prevented.

  15. Ciudad, espacio y ceguera en ciudad Juárez México / City, Space, and Blindness Juárez, México

    Directory of Open Access Journals (Sweden)

    Maria Esther Vega-Ocampo

    2015-05-01

    Full Text Available Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Cambria;} Resumen. La comunidad ciega en ciudad Juárez Mexico en frontera con Estados Unidos, mantiene en nuestros días una ausencia participativa en lo cotidiano, la estructura urbana de poca inclusión, los lleva crear alternativas para su movilidad. El objetivo  de este estudio es comprender y analizar cómo es la interacción social y espacial del ciego en una ciudad deshabilitada para su movilidad. Se utilizo un enfoque cualitativo que permitiese una observación cercana al grupo mediante entrevistas semi estructurada y observación participante, se escogió a un grupo de jóvenes ciegos que asisten a la Escuela para Ciegos Luis Braille. Se encontró que la ciudad  muestra un reflejo marginal que genera restricciones en su traslado, movilidad y aprendizaje espacial manteniendo una difícil autonomía.   Abstract: The community of visually impaired persons in Ciudad Juarez, Mexico, sitting astride the United States border, is practically absent from the city's day-to-day life. Providing negligible accommodations, Ciudad Juarez is not an inclusive environment and thus the visually impaired must auto-construct their own means of mobility to get out into the broader community they inhabit. The objective of this study is to analyze and understand the social and spacial interaction of the visually impaired in a northern Mexican border city entirely unequipped for them. The study focuses on a group of students at the Luis Braille School for the Blind in Ciudad Juarez, who were interviewed and observed during a prolonged period of time, and concludes that

  16. The AKARI FU-HYU galaxy evolution program: first results from the GOODS-N field

    Science.gov (United States)

    Pearson, C. P.; Serjeant, S.; Negrello, M.; Takagi, T.; Jeong, W.-S.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M. S.

    2010-05-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands. We present the initial results for the FU-HYU survey in the GOODS-N field. We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produce a bimodal distribution where an excess at 11 microns preferentially selects moderate redshift star-forming galaxies. These powerful colour-colour diagnostics are further used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field showing that dusty starbursts can be selected of specific redshift ranges (z = 1.2-1.6) by mid-infrared drop-out techniques. The FU-HYU catalogue will be made publically available to the astronomical community.

  17. How Can Asian Snack FuLoi Plan Successful Entering to Greater Helsinki Area? : Market research

    OpenAIRE

    Nguyen, Loc

    2014-01-01

    This thesis introduces the significant factors of market research and its importance when considering doing international business. Furthermore, it could be useful for investors who have same favour to enter Finnish market. The case company is Asian Snack FuLoi- a German food industry company looking for new market. The goal of this study was to investigate the possibility for a company to enter Finland in general and Greater Helsinki in particular. The thesis was structured with theor...

  18. AN ANALYSIS OF THE ENVIRONMENTS OF FU ORIONIS OBJECTS WITH HERSCHEL

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel [Department of Astronomy, The University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Kospal, Agnes [European Space Agency (ESA/ESTEC), Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Herczeg, Gregory [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quanz, Sascha P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Henning, Thomas; Bouwman, Jeroen [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Van Kempen, Tim A. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300-RA Leiden (Netherlands); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of); Dunham, Michael M. [Department of Astronomy, Yale University, New Haven, CT (United States); Meeus, Gwendolyn [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Campus Cantoblanco (Spain); Chen, Jo-hsin [Jet Propulsion Laboratory, Pasadena, CA (United States); Guedel, Manuel; Liebhart, Armin [Department of Astrophysics, University of Vienna (Austria); Skinner, Stephen L., E-mail: joel@astro.as.utexas.edu [Center for Astrophysics and Space Astronomy (CASA), University of Colorado, Boulder, CO 80309-0389 (United States)

    2013-08-01

    We present Herschel-HIFI, SPIRE, and PACS 50-670 {mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the 'FOOSH' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L{sub bol}, T{sub bol}, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of {sup 13}CO (J{sub up} of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 {yields} 22 and evidence for H{sub 2}O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for 'cool' CO components range from 20 to 81 K, for {approx} 10{sup 50} total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.

  19. Translation Methods Used In Writing Indonesian Subtitles Of “Kung Fu Panda Holiday”

    OpenAIRE

    NURMALLAH, HERDIANTI

    2013-01-01

    In Indonesia, western movies that are spoken in English make the need for Indonesian subtitles increase. To make subtitles in different language, translation has an important role. The translator must use appropriate methods to produce good translation. This study aims to find out the kinds of translation methods used in writing Indonesian subtitles of the movie “Kung Fu Panda Holiday” by using Newmark's theory (1988). This study uses descriptive qualitative approach with document analysis. T...

  20. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda)

    OpenAIRE

    Riyo Ramadhan; Hafiz Aziz Ahmad; Alvanov Z. Mansoor

    2017-01-01

    Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll), yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Ha...

  1. Posmodernisme Dalam Novel Generation X: Tales For Accelerated Culture Dan Bilangan Fu

    OpenAIRE

    Azmi, Nurul Nayla

    2013-01-01

    This research is entitled Postmodernism in Novel Generation X: Tale of Accelerated Culture and Bilangan Fu which analyze postmodernism as the concept in both novel. As generally known, that the fast growing of recent life has effecting the human’s life that change continuity started from traditional, modern and then to the latest which postmodernism. In the changing of each stage, human life also encounters the changing which may seen from happening social phenomenon. In the stage of postmo...

  2. Treatment results of chemoradiotherapy with 5-FU/CDGP for head and neck cancer

    International Nuclear Information System (INIS)

    Himei, Kengo; Katayama, Norihisa; Takemoto, Mitsuhiro; Kuroda, Masahiro; Nomiya, Shigenobu; Onoda, Tomoo; Tominaga, Susumu; Kanazawa, Susumu

    2006-01-01

    We investigated the safety and efficacy of alternative and concurrent chemoradiotherapy with 5-fluorouracil (FU)/nedaplatin (CDGP) for head and neck cancer. From January 2003 to August 2005, 19 patients with head and neck squamous cell carcinoma were treated in our institution. Alternative chemoradiotherapy (ACRT) was performed for 8 cases of nasopharyngeal cancer. Concurrent chemoradiotherapy (CCRT) was performed for 11 cases of other head and neck cancer. Median total dose of radiotherapy was 63 Gy. ACRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-5 and 28-32 and CDGP at a dose of 60 mg/m 2 on days 6 and 33. CCRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-4 and 28-31 and CDGP at a dose of 60 mg/m 2 on days 5 and 32. Median follow-up period was 13 months. CR+PR was admitted in five cases (63%) with ACRT, and in 9 cases (82%) with CCRT. Non-hematological adverse effects of grade 3 were admitted in eight cases (100%) of ACRT, and in 9 cases (82%) of CCRT. Chemoradiotherapy attained good results and non-hematological adverse effects were able to be managed by preserved treatment. (author)

  3. The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.

    Directory of Open Access Journals (Sweden)

    Joshua E Allen

    Full Text Available Phenylbutyl isoselenocyanate (ISC-4 is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to improve the clinical utility of ISC-4 by identifying a synergistic combination with FDA-approved anti-cancer therapies, a relevant and appropriate disease setting for testing, and biomarkers of response. We tested the activity of ISC-4 and 19 FDA-approved anticancer agents, alone or in combination, against the SW480 and RKO human colon cancer cell lines. A synergistic interaction with cetuximab was identified and validated in a panel of additional colon cancer cell lines, as well as the kinetics of synergy. ISC-4 in combination with cetuximab synergistically reduced the viability of human colon cancer cells with wild-type but not mutant KRAS genes. Further analysis revealed that the combination therapy cooperatively decreased cell cycle progression, increased caspase-dependent apoptosis, and decreased phospho-Akt in responsive tumor cells. The synergism between ISC-4 and cetuximab was retained independently of acquired resistance to 5-FU in human colon cancer cells. The combination demonstrated synergistic anti-tumor effects in vivo without toxicity and in the face of resistance to 5-FU. These results suggest that combining ISC-4 and cetuximab should be explored in patients with 5-FU-resistant colon cancer harboring wild-type KRAS.

  4. Fluorescence and computational studies of thymidine phosphorylase affinity toward lipidated 5-FU derivatives

    Science.gov (United States)

    Lettieri, R.; D'Abramo, M.; Stella, L.; La Bella, A.; Leonelli, F.; Giansanti, L.; Venanzi, M.; Gatto, E.

    2018-04-01

    Thymidine phosphorylase (TP) is an enzyme that is up-regulated in a wide variety of solid tumors, including breast and colorectal cancers. It is involved in tumor growth and metastasis, for this reason it is one of the key enzyme to be inhibited, in an attempt to prevent tumor proliferation. However, it also plays an active role in cancer treatment, through its contribution in the conversion of the anti-cancer drug 5-fluorouracil (5-FU) to an irreversible inhibitor of thymidylate synthase (TS), responsible of the inhibition of the DNA synthesis. In this work, the intrinsic TP fluorescence has been investigated for the first time and exploited to study TP binding affinity for the unsubstituted 5-FU and for two 5-FU derivatives, designed to expose this molecule on liposomal membranes. These molecules were obtained by functionalizing the nitrogen atom with a chain consisting of six (1) or seven (2) units of glycol, linked to an alkyl moiety of 12 carbon atoms. Derivatives (1) and (2) exhibited an affinity for TP in the micromolar range, 10 times higher than the parent compound, irrespective of the length of the polyoxyethylenic spacer. This high affinity was maintained also when the compounds were anchored in liposomal membranes. Experimental results were supported by molecular dynamics simulations and docking calculations, supporting a feasible application of the designed supramolecular lipid structure in selective targeting of TP, to be potentially used as a drug delivery system or sensor device.

  5. Development of FuGO: An Ontology for Functional Genomics Investigations

    Science.gov (United States)

    Whetzel, Patricia L.; Brinkman, Ryan R.; Causton, Helen C.; Fan, Liju; Field, Dawn; Fostel, Jennifer; Fragoso, Gilberto; Gray, Tanya; Heiskanen, Mervi; Hernandez-Boussard, Tina; Morrison, Norman; Parkinson, Helen; Rocca-Serra, Philippe; Sansone, Susanna-Assunta; Schober, Daniel; Smith, Barry; Stevens, Robert; Stoeckert, Christian J.; Taylor, Chris; White, Joe; Wood, Andrew

    2009-01-01

    The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. PMID:16901226

  6. Aspectos epidemiológicos da Leishmaniose Tegumentar Americana no município de Juína, Mato Grosso, Brasil = Epidemiological aspects of American Cutaneous Leishmaniasis in the city of Juína, Mato Grosso state, Brazil

    Directory of Open Access Journals (Sweden)

    França, Eduardo Luzia

    2009-01-01

    Conclusões: a análise dos dados revelou que a Leishmaniose Tegumentar Americana é uma parasitose importante no município de Juína. Os dados sugerem relação com a atividade laboral e um perfil de transmissão predominantemente silvestre, o que deve ser levado em conta ao definir medidas de controle da doença na região

  7. [Epidemiology of gunshot wounds at Ciudad Juárez, Chihuahua General Hospital].

    Science.gov (United States)

    Moye-Elizalde, G A; Ruiz-Martínez, F; Suarez-Santamaría, J J; Ruiz-Ramírez, M; Reyes-Gallardo, A; Díaz-Apodaca, B A

    2013-01-01

    Since 2007, Ciudad Juárez, Chihuahua has been considered as one of the most violent cities in the world. The General Hospital in this city is the main facility where patients with gunshot wounds are taken. The increased number of admissions of patients with these injuries to many hospitals in the country deserves special attention, as it has an impact on hospital resources and management protocols. To disseminate the epidemiology of fractures caused by gunshot wounds and the hospital care of these patients. A retrospective, observational cohort study was conducted of patients admitted to the Traumatology and Orthopedics Service, Cd. Juárez General Hospital, in Chihuahua, Mexico, from January 2008 to December 2010. All of them sustained fractures resulting from gunshot wounds. A total of 1281 patients with a diagnosis of gunshot wounds were admitted to the hospital; 402 of them were included in this study with 559 fractures; 329 were males and 73 females. Of the 559 fractures, 257 involved the upper limb, 294 the lower limb, and 8 the pelvis. Gunshot wounds-related fractures were classified according to the Gustilo classification. Seventy-nine patients had grade I fractures, 302 grade III, and 21 patients had both grades. Conservative treatment was used in 44.3% of fractures and osteosynthesis in 55%. One patient underwent amputation upon admission. The most widely used osteosynthesis methods were external fixator (37%), straight plates (21%) and intramedullary nail (17%). Five patients (1.3%) underwent amputation: two with femur fracture and 3 with humeral fracture. There were 27 deep infections (6%); one of them resulted in late amputation of the pelvic limb. The most common associated injuries included: chest injuries in 20 patients and abdominal injuries in 17. The range of hospital stay was 1-18 days, with a mean stay of 11 days. The overall mortality rate considering the total number of patients admitted (1,281) was 99 patients (7.72%). From 2006 to 2010 the

  8. Turismo industrial: oportunidades y retos dentro del sector de manu- factura en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Francisco Arturo Bribiescas Silva

    2015-01-01

    Full Text Available Turismo Industrial, tema relevante dentro de la región fronteriza Ciudad Juá-rez-El Paso, donde la Industria de manufactura tiene gran dinamismo eco-nómico, y se visualizan expectativas y propuestas innovadoras a este sector. Este trabajo es una exploración de las oportunidades y retos de la industria manufacturera instalada en Ciudad Juárez para desarrollar actividades de turismo industrial en sus instalaciones. La información se obtuvo a través de entrevistas a profundidad con 15 gerentes de las empresas más importantes de esta región. Dentro de los resultados se puede observar que las actividades del turismo industrial son percibidas por los gerentes entrevistados como benéficas y consideradas como una actividad alterna a la manufactura.

  9. The process of dissemination of kung fu in west – between sense of loss and inevitability loss of sense

    Directory of Open Access Journals (Sweden)

    Fernando Dandoro Castilho Ferreira

    2017-07-01

    Full Text Available In this paper, we discuss aspects of the development process of Kung Fu in China and its subsequent spread to the West in the light of sociological theory of Norbert Elias. To meet this goal, we have structured the text into three parts. In the first, we present some elements of theory of Elias that are useful to study Kung Fu. In the second part of the article, in turn, bring some evidence about the Kung Fu diffusion process to the West, taking as a reading aid work “Shaolin Monastery” of Meir Shahar. The third and final part of the text, we suggest that the reception of Kung Fu in the West engenders a social process that combines elements of Chinese tradition and capitalist modernity, giving the practice a hybrid and ambiguous character.

  10. Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

    DEFF Research Database (Denmark)

    Buhl, Ida Kappel; Gerster, Sarah; Delorenzi, Mauro

    2016-01-01

    patients who benefitted from the addition of irinotecan to 5-FU, we used gene expression profiles based on cell lines and clinical tumor material. These profiles were applied to expression data obtained from pretreatment formalin fixed paraffin embedded (FFPE) tumor tissue from 636 stage III colon cancer...... patients enrolled in the PETACC-3 prospective randomized clinical trial. A 5-FU profile developed similarly was assessed by comparing the PETACC-3 cohort with a cohort of 359 stage II colon cancer patients who underwent surgery but received no adjuvant therapy. RESULTS: There was no statistically...... to identify colon cancer patients who may benefit from 5-FU, however, any biomarker predicting benefit for adjuvant 5-FU must be rigorously evaluated in independent cohorts. Given differences between the two study cohorts, the present results should be further validated....

  11. EVIDENCE FOR AN FU ORIONIS-LIKE OUTBURST FROM A CLASSICAL T TAURI STAR

    International Nuclear Information System (INIS)

    Miller, Adam A.; Poznanski, Dovi; Silverman, Jeffrey M.; Kleiser, Io K. W.; Cenko, S. Bradley; Bloom, Joshua S.; Filippenko, Alexei V.; Hillenbrand, Lynne A.; Kasliwal, Mansi M.; Ofek, Eran O.; Quimby, Robert M.; Covey, Kevin R.; Rojas-Ayala, Barbara; Muirhead, Philip S.; Law, Nicholas M.; Dekany, Richard G.; Rahmer, Gustavo; Hale, David; Smith, Roger; Nugent, Peter

    2011-01-01

    We present pre- and post-outburst observations of the new FU Orionis-like young stellar object PTF 10qpf (also known as LkHα 188-G4 and HBC 722). Prior to this outburst, LkHα 188-G4 was classified as a classical T Tauri star (CTTS) on the basis of its optical emission-line spectrum superposed on a K8-type photosphere and its photometric variability. The mid-infrared spectral index of LkHα 188-G4 indicates a Class II-type object. LkHα 188-G4 exhibited a steady rise by ∼1 mag over ∼11 months starting in August 2009, before a subsequent more abrupt rise of >3 mag on a timescale of ∼2 months. Observations taken during the eruption exhibit the defining characteristics of FU Orionis variables: (1) an increase in brightness by ∼>4 mag, (2) a bright optical/near-infrared reflection nebula appeared, (3) optical spectra are consistent with a G supergiant and dominated by absorption lines, the only exception being Hα which is characterized by a P Cygni profile, (4) near-infrared spectra resemble those of late K-M giants/supergiants with enhanced absorption seen in the molecular bands of CO and H 2 O, and (5) outflow signatures in H and He are seen in the form of blueshifted absorption profiles. LkHα 188-G4 is the first member of the FU Orionis-like class with a well-sampled optical to mid-infrared spectral energy distribution in the pre-outburst phase. The association of the PTF 10qpf outburst with the previously identified CTTS LkHα 188-G4 (HBC 722) provides strong evidence that FU Orionis-like eruptions represent periods of enhanced disk accretion and outflow, likely triggered by instabilities in the disk. The early identification of PTF 10qpf as an FU Orionis-like variable will enable detailed photometric and spectroscopic observations during its post-outburst evolution for comparison with other known outbursting objects.

  12. High-Resolution Near-Infrared Spectroscopy of FU Orionis Objects

    Science.gov (United States)

    Hartmann, Lee; Hinkle, Kenneth; Calvet, Nuria

    2004-07-01

    We present an analysis of recent near-infrared, high-resolution spectra of the variable FU Ori objects. During a phase of rapid fading in optical brightness during 1997, V1057 Cyg exhibited shell absorption in first-overtone (v''-v'=2-0) CO lines, blueshifted by about 50 km s-1 from the system velocity. This shell component had not been seen previously, nor was it present in 1999, although some blueshifted absorption asymmetry is seen at the latter epoch. The appearance of this CO absorption shell is connected with the roughly contemporaneous appearance of blueshifted, low-excitation optical absorption lines with comparable low velocities; we suggest that this shell was also responsible for some of the peculiar emission features seen in red-optical spectra of V1057 Cyg. FU Ori continues to exhibit broad CO lines, with some evidence for the double-peaked profiles characteristic of an accretion disk; the line profiles are consistent with previous observations. Both FU Ori and V1057 Cyg continue to exhibit lower rotational broadening at 2.3 μm than at optical wavelengths, in agreement with the prediction of differentially rotating disk models; we have a marginal detection of the same effect in V1515 Cyg. The relative population of the first-overtone CO rotational levels in the FU Ori objects suggests low excitation temperatures. We compare disk models to the observations and find agreement with overall line strengths and rotational broadening, but the observed line profiles are generally less double-peaked than predicted. We suggest that the discrepancy in line profiles is due to turbulent motions in FU Ori disks, an effect qualitatively predicted by recent simulations of the magnetorotational instability in vertically stratified accretion disks. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under a cooperative agreement with the NSF, on behalf of the Gemini

  13. [Anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines in vitro].

    Science.gov (United States)

    Gu, Jun; Li, Maolan; Wu, Xiangsong; Wu, Wenguang; Zhang, Lin; Ding, Qichen; Yang, Jiahua; Weng, Hao; Ding, Qian; Bao, Runfa; Shu, Yijun; Liu, Yingbin

    2014-04-01

    To prepare cisPLLAtin-loaded polylactic acid/cnts, and to study the anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines(MGC803 and MNK45). 5-FU-PLLA-CNTs were prepared with ultrasound emulsification. The morphology of 5-FU-PLLA-CNTs was determined by scanning electron microscope(SEM), and its drug loading and drug release curve in vitro were detected by UV-Vis-NIR spectrophotometer. Cells were divided into experiment, positive control and negative control groups. CCK8 method was used to test the cytotoxic effect of 5-FU-PLLA-CNTs in different concentrations on MGC803 and MNK45 cell proliferation. Flow cytometry was employed to measure the apoptotic rate of MGC803 and MNK45 cells before and after the intervention of 5-FU-PLLA-CNTs. Deep layer film of 5-FU-PLLA-CNTs was successfully established, whose drug-load rate was(4.54±0.43)%, entrapment rate was(21.56±2.36)%. In vitro release test showed release rate within 24 h of 5-FU-PLLA-CNTs was 23.9% in a as lowly increasing manner, and accumulating release rate was 85.3% at day 31. CCk8 experiment revealed, as compared to control group, 5-FU-PLLA-CNTs significantly inhibited the proliferation of two cell lines in dose-dependent and time-dependent manner. The best 5-FU-PLLA-CNTs concentration of inhibition for human gastric cancer cell lines was 1 mg/well. Flow cytometry indicated the apoptotic rate of MGC803 and MNK45 cells in experiment group treated by 1 mg/well 5-FU-PLLA-CNTs significantly increased as compared to negative control group (P0.05). The 5-FU-PLLA-CNTs has good drug sustained-release capacity, and can significantly kill and inhibit the proliferation of MGC803 and MNK45 cell lines.

  14. Why do Breadwinners Leave Home? Book Review: Plusnin Ju. et al. (2013) Otkhodniks, Moscow: Novyy khronograph (in Russian)

    OpenAIRE

    Svetlana Barsukova

    2015-01-01

    The presented book review is devoted to “Otkhodniks” by Plusnin Ju., Zausaeva Ya., Zhidkevich N., Pozanenko A. (editor — S. Kordonsky). Otkhodnichestvo is a type of labor migration implying a scenario in which an adult, able-bodied family member temporarily leaves home to seek work in another area. Otkhodnichestvo has a long history in Russia but a new wave of its mass dissemination appeared in recent decades. The reviewed book defines a concept of otkhodnichestvo, considers what similarities...

  15. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    Directory of Open Access Journals (Sweden)

    Kurt Wachter

    2010-03-01

    Full Text Available Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  16. Capacitación de líderes comunitarios como gestores sociales en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Carmen Álvarez

    2015-01-01

    Full Text Available El trabajo consiste en describir el desarrollo de un esquema de capacitación de líderes co - munitarios. El enfoque de la formación está dirigido a la gestión de proyectos de incidencia en las comunidades, basándose en diagnósticos participativos. El taller de formación de líderes comunitarios fue desarrollado por la Comisión Nacional para Prevenir y Erradicar la Violencia contra las Mujeres (Conavim en conjunto con la Universidad Autónoma de Ciudad Juárez y la Fundación del Empresariado Chihuahuense (Fechac y se diseñó tomando en consideración el ambiente de crisis social y de seguridad por la que atravesó Ciudad Juárez, así como en las necesidades de capacitación de promotores sociales expresadas en el programa “Todos somos Juárez”.

  17. El impuesto predial en Ciudad Juárez desde una perspectiva de equidad

    Directory of Open Access Journals (Sweden)

    Sergio Peña-Medina

    2016-01-01

    Full Text Available El aspecto de equidad en el impuesto predial es un tema relevante que se aborda en este artículo. Ésta se diferencia entre vertical y horizontal; la primera se refiere a un enfoque progresivo en donde aquellas propiedades que valen más pagan una tasa superior a las de menor valor; la equidad horizontal apunta a un tema de valuación y, en ella, las propiedades comparables pagan la misma tasa. El artículo tiene como objetivo poner a prueba la hipótesis de regresividad del impuesto predial; se argumenta que ésta es inequitativa dado que en términos proporcionales las propiedades de menor valor pagan una tasa superior a las de mayor valor. Los resultados en esta investigación soportan la hipótesis de que existe un efecto de regresividad en el impuesto predial en Ciudad Juárez; consecuentemente es importante reflexionar sobre la estructura actual del sistema catastral.

  18. La cultura del feminicidio en Ciudad Juárez, 1993-1999

    Directory of Open Access Journals (Sweden)

    Julia Estela Fragoso Monárrez

    2000-01-01

    Full Text Available El proposito de esta investigación es analizar los asesinatos cometidos contra niñas y mujeres de Ciudad Juárez en los años de 1993 a 1999, a través de la categoría analítica del feminicidio. Diferenciar las distintas clases de feminicidios y delinear los perfiles sociodemográficos de vulnerabilidad de las niñas y las mujeres asesinadas. Finalmente clasificar la relación de parentesco entre la víctima y el victimario. Los datos se recolectaron de fuentes secundarias y oficiales para 162 víctimas. Los resultados arrojan un perfil preliminar sociodemográfico de las víctimas y confirman la existencia de varios tipos de feminicidios en algunos casos en relación a la ocupación de las víctimas. En cuanto a la noción de un asesino serial o una epidemia de machismo que repite patrones de exterminio, ambas categorías se encuentran presentes. Los resultados también confirman una relación de parentesco o desconocimiento entre las víctimas y el victimario

  19. Carbon monoxide exposure in households in Ciudad Juárez, México.

    Science.gov (United States)

    Montoya, Teresa; Gurian, Patrick L; Velázquez-Angulo, Gilberto; Corella-Barud, Verónica; Rojo, Analila; Graham, Jay P

    2008-03-01

    This study assessed exposure to carbon monoxide from gas and wood heater emissions in a sample of 64 households in peri-urban residential areas in Ciudad Juárez, Chihuahua, México. Indoor and outdoor carbon monoxide concentrations and temperatures were monitored for a continuous period of 1 week at 1 and 6-min intervals, respectively. The moving average carbon monoxide concentrations were compared to the World Health Organization (WHO) standards for carbon monoxide. Sixty-seven percent of households with gas heaters and 60% of households with wood heaters exceeded a health-based standard at some point during the monitoring. The difference between indoor and outdoor temperatures was modestly correlated with average carbon monoxide exposure (r=0.35, p-value h standard of 9ppm (odds ratio=5.1, p-value=0.031). These results highlight the need for further efforts to identify and mitigate potentially hazardous carbon monoxide exposures, particularly in moderate-income countries with cooler climates.

  20. Radio-chemo-therapy with 5FU and cisplatin for bladder cancer after TUR-bladder

    International Nuclear Information System (INIS)

    Schuchardt, U.; Birkenhake, S.; Leykam, S.; Martus, P.; Sauer, R.

    1996-01-01

    Purpose/Objective: To determine toxicity and efficacy of radio-chemo-therapy (RCT) with 5FU and cisplatin in patients with bladder cancer. Endpoints are initial response, cystectomy-rates and overall-survival. Materials and Methods: From 11/93 to 1/95 13 patients suffering from bladder cancer were first treated with TUR-bladder (TURB). Patient characteristics were as follows: Within 6 weeks after operation the pelvis was irradiated with 54.0 Gy (median) in conventional fractionation (10 MV photons 4-field-box). The bladder was boosted up to 59.4 Gy (median) in isocentric rotation technique. 7 patients were treated with 45 Gy paraaortal. During the first and 5th treatment week chemotherapy (CT) was simultaneously given: 800 mg/m 2* d CISPLATIN as bolus-infusion 30 min prior to RT. 2 months later a further TURB was performed for restaging. Cystectomy was recommended, if invasive cancer was found at this time. Acute hematological and gastrointestinal toxicity was recorded according to the WHO-criteria. Results: At least 81% (e.g. 75% of 2nd course) of CT was applied in 10/13 patients. Median doses were 3500 mg/m 2 5FU and 200 mg/m 2 CISPLATIN. Acute toxicity to bladder and bowel reached grade 2 WHO only. Hematotoxicity (median values) and results ar shown in the following table. Conclusion: Concomitant RCT with 5FU and CISPLATIN seems to be a promising modality for organ-preserving therapy of bladder cancer. Preliminary results show sufficient effect and acceptable toxicity. Since patient number is still low, further investigation is recommended

  1. A inserção do kung fu no Brasil na perspectiva dos mestres pioneiros

    OpenAIRE

    Ferreira, Fernando Dandoro Castilho

    2013-01-01

    Resumo: Discutir atualmente a China e sua cultura parece algo bastante útil, principalmente em decorrência da sua posição econômica, que exerce uma impactante influência mundial. Para buscar trazer alguma luz sobre a China, fizemos uso de um marcante e elucidativo elemento de sua cultura, a sua arte marcial. Mais ainda, buscamos avançar neste processo tratando não do Kung Fu em seu berço de origem, mas sim, olhando-o em sua vertente contemporânea, oriunda do processo de disseminação deste em ...

  2. Electrochemical degradation of 5-FU using a flow reactor with BDD electrode: Comparison of two electrochemical systems.

    Science.gov (United States)

    Ochoa-Chavez, A S; Pieczyńska, A; Fiszka Borzyszkowska, A; Espinoza-Montero, P J; Siedlecka, E M

    2018-06-01

    In this study, the electrochemical degradation process of 5-fluorouracil (5-FU) in aqueous media was performed using a continuous flow reactor in an undivided cell (system I), and in a divided cell with a cationic membrane (Nafion ® 424) (system II). In system I, 75% of 5-FU degradation was achieved (50 mg L -1 ) with a applied current density j app  = 150 A m -2 , volumetric flow rate qv = 13 L h -1 , after 6 h of electrolysis (k app  = 0.004 min -1 ). The removal efficiency of 5-FU was higher (95%) when the concentration was 5 mg L -1 under the same conditions. Nitrates (22% of initial amount of N), fluorides (27%) and ammonium (10%) were quantified after 6 h of electrolysis. System II, 77% of 5-FU degradation was achieved (50 mg L -1 ) after 6 h of electrolysis (k app  = 0.004 min -1 ). The degradation rate of 5-FU was complete when the concentration was 5 mg L -1 under the same conditions. Nitrates (29% of initial amount of N), fluorides (25%) and ammonium (5%) were quantified after 6 h of electrolysis. In addition, the main organic byproducts identified by mass spectroscopy were aliphatic compound with carbonyl and carboxyl functionalities. Due to, the mineralization of 5-FU with acceptable efficiency of 88% found in system II (j app of 200 A m -2 ), this system seems to be more promising in the cytostatic drug removal. Moreover the efficiency of 5-FU removal in diluted solutions is better in system II than in system I. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer

    Directory of Open Access Journals (Sweden)

    Yang K

    2016-11-01

    Full Text Available Kai Yang, Kai Gao, Gui Hu, Yanguang Wen, Changwei Lin, Xiaorong Li Department of General Surgery, The Third Affiliated Hospital of Central South University, Central South University, Changsha, Hunan, People’s Republic of China Abstract: Colorectal cancer (CRC is one of the most commonly diagnosed cancers among both males and females; the chemotherapy drug 5-fluorouracil (5-FU is one of a doctors’ first lines of defense against CRC. However, therapeutic failures are common because of the emergence of drug resistance. Connective tissue growth factor (CTGF is a secreted protein that binds to integrins, and regulates the invasiveness and metastasis of certain carcinoma cells. Here, we found that CTGF was upregulated in drug-resistant phenotype of human CRC cells. Overexpression of CTGF enhanced the resistance to 5-FU-induced cell apoptosis. Moreover, downregulating the expression of CTGF promoted the curative effect of chemotherapy and blocked the cell cycle in the G1 phase. We also found that CTGF facilitated resistance to 5-FU-induced apoptosis by increasing the expression of B-cell lymphoma-extra large (Bcl-xL and survivin. Then we pharmacologically blocked MEK/ERK signal pathway and assessed 5-FU response by MTT assays. Our current results indicate that the expression of phosphorylated forms of MEK/ERK increased in high CTGF expression cells and MEK inhibited increases in 5-FU-mediated apoptosis of resistant CRC cells. Therefore, our data suggest that MEK/ERK signaling contributes to 5-FU resistance through upstream of CTGF, and supports CRC cell growth. Comprehending the molecular mechanism underlying 5-FU resistance may ultimately aid the fight against CRC. Keywords: connective tissue growth factor, 5-fluorouracil, mitogen-activated protein kinase/extracellular regulated protein kinases, phosphatidyl inositol 3-kinase/serine/threonine kinase Akt, colorectal cancer

  4. Violencias en el Norte de México: el caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Alberto Aziz Nassif

    2014-06-01

    Full Text Available En este trabajo se hace un análisis de los diferentes tipos de violencia que se generan en la crisis de una ciudad que fue abatida por las bandas del narcotráfico en la frontera de México con Estados Unidos. Hay efecto combinado de guerra entre cárteles por el control de la plaza, que se mezcla con la mala estrategia de enfrentamiento y la penetración de los cuerpos policíacos, lo que da como resultado una amplia destrucción de personas, familias y espacios. Las violencias se construyen porque hay causas estructurales, como el modelo de ciudad, porque hay una deficiente presencia del Estado y por una estrategia de guerra entre cárteles. Todo esto produce la crisis de violencia que se vive en Ciudad Juárez.   Abstract   This paper provides an analysis of the different types of violence that are generated in the crisis of a city that was shot down by drug gangs in Mexico’s border with the United States. The combined effects of the war between cartels for control of the square, mixed with the bad strategy of confrontation and the penetration of the police forces give as a result extensive destruction of individuals, families and spaces. Violence is built because there are structural causes such as the city’s model, because there is a weak State presence and war strategy between cartels. All this results in the violence crisis that exists in Ciudad Juarez.

  5. Nedaplatin and 5-FU combined with radiation in the treatment for esophageal cancer

    International Nuclear Information System (INIS)

    Yamanaka, Hideharu; Motohiro, Takayuki; Michiura, Taku; Asai, Akira; Mori, Tsuyoshi; Hioki, Koshiro

    1998-01-01

    A series of patients with esophageal cancer was treated with chemotherapeutic regimens of the new antitumor platinum preparation nedaplatin plus 5-FU in combination with radiation therapy, and the therapeutic responses, side effects, and complications were clinically assessed. There were 2 patients with a complete response and 11 patients with a partial response, hence, a response rate of 76.5%. Major adverse reactions were those of hematological toxicity and included leukopenia (13 patients, 76.5%), thrombocytopenia (8 patients, 47.1%), and lowered serum hemoglobin concentration (9 patients, 52.9%). The leukopenia and thrombocytopenia, though of a grade 3 severity in 3 and 2 patients, respectively, subsided spontaneously in all affected cases. Gastrointestinal adverse reactions were mild and included appetite loss in 7 patients (41.2%) and nausea in 2 patients (11.8%). The only abnormality in renal function observed was a slight elevation of serum creatinine in one patient. The combined therapy of chemotherapy with nedaplatin and 5-FU plus radiation produced a high response rate in the treatment of carcinoma of the esophagus and was associated with reduced gastrointestinal and renal toxicity. The results indicate the combined therapy with nedaplatin to be clinically useful. (author)

  6. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda

    Directory of Open Access Journals (Sweden)

    Riyo Ramadhan

    2017-09-01

    Full Text Available Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll, yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Hal ini mengakibatkan para generasi muda memandang seni bela diri impor menjadi lebih superior ketimbang pencak silat. Jika hal ini terus berlangsung tanpa ada usaha untuk mengembangkan pencak silat melalui media modern, maka akan sangat sulit untuk mempertahankan dan mengembangkan tradisi ini di masa depan. Tujuan dari makalah ini ialah untuk membuktikan dan menggali potensi animasi sebagai media alternatif yang efektif untuk memvisualisasikan adegan dan cerita bertemakan pencak silat. Adapun studi kasus yang menjadi acuan dalam penelitian ialah film animasi “Kung Fu Panda”. Penelitian ini mengkaji studi kasus dengan menggunakan metode kualitatif deskriptif, lalu dianalisis dengan pendekatan analisis deskriptif untuk mengkaji dan mengidentifikasi pemasalahan dan solusi. Pembahasan dari makalah lebih ditekankan pada kekuatan penyampaikan cerita melalui gambar (visual storytelling yang efektif terkait dengan pencak silat. Hasil dari penelitian ialah cara penyampaian pesan yang efektif mengenai elemen dan esensi pencak silat sebagai bentuk translasinya kedalam film animasi. Pesan tersebut dapat disampaikan dengan menggunakan aspek narasi, gesture, dan simbol yang diakomodasi dengan aspek visual storytelling. Translating Pencak Silat Into An Animation Film (Case Study The Film Kung Fu Panda Abstract. A tradition that has been part of Indonesian culture since ancient times, pencak silat was born as a form of self-defense and at the same time has grown into an

  7. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin

    OpenAIRE

    Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

    2017-01-01

    Background Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. Methods 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the ...

  8. A juçara vai à escola: aprendizagem entre pessoas, coisas e instituições

    Directory of Open Access Journals (Sweden)

    Marcelo Gules Borges

    2015-12-01

    Full Text Available ResumoEste artigo é resultado de uma etnografia sobre materialidade, educação e aprendizagem realizada no contexto de uma rede local de educadoras ambientais atuantes em escolas públicas de ensino fundamental no litoral norte do Rio Grande do Sul, no Brasil. Tivemos por objetivo seguir as linhas que constituem o protagonismo da palmeira juçara, Euterpe edulis, espécie botânica conhecida popularmente como açaí da Mata Atlântica. Estivemos atentos aos seus usos nas práticas de alimentação e educação ambiental desenvolvidas pelas educadoras da Teia (Teia de Educação Ambiental da Mata Atlântica. Desde nossa perspectiva, a juçara é um outro não humano que participa de uma trama de relações sociais e materiais, entrelaçando pessoas, coisas e instituições e está no centro de um feixe de processos de aprendizagem individuais, sociais e ambientais. Dialogamos com uma noção de aprendizagem pensada a partir dos modos pelos quais experiências educativas são vividas nos termos de uma sintonia fina e dos laços de copertencimento com a dimensão não humana do ambiente, estabelecendo laços produtivos com outros humanos e não humanos. Nesse sentido, descrevemos a convivência entre as educadoras e a juçara como oportunidade para compreender formas de aprendizagem escolar e não escolar em uma comunidade rural no Rio Grande do Sul que, como qualquer outra, é constituída por um mundo mais que humano.

  9. Primerjalna analiza medijskega oglaševanja slovenskih in tujih podjetij na socialnem omrežju Facebook

    OpenAIRE

    Božič, Rina

    2015-01-01

    Nenehen napredek v tehnologiji ima velik vpliv na trženjsko komunikacijo, ki se spreminja skozi čas. Podjetje mora dobro poznati prednosti svojih izdelkov in jih predstaviti ciljnim skupinam. Zaradi večjega dosega in boljše cenovne učinkovitosti podjetja uporabljajo oglaševanje preko socialnih omrežij. Tako lažje določijo ciljno skupino in merijo rezultate oglasa. V današnjem okolju je za preživetje na trgu nujno potreben tehnološki razvoj in sledenje novostim na področju trženja. Opisana...

  10. Entwicklung einer Methode zur monetären Bewertung des Wassers für ein Unternehmen unter Einbeziehung des Wasser-Fußabdrucks

    OpenAIRE

    Hentschel, Nora

    2011-01-01

    Wassernutzung und Abbau der Frischwasser-Ressourcen sind heutzutage ein Thema, das als so wichtig wahrgenommen wird wie der Klimawandel. Wasser wird somit zunehmend Auswirkungen auf den ökonomischen Wert von Unternehmen haben. Ziel der vorliegenden Arbeit ist es, den monetären Wert des Wassers mithilfe des Wasser-Fußabdrucks zu bestimmen. Hierfür werden nach einer kurzen Einführung in Kapitel 2 der ökologische Fußabdruck, der CO2-Fußabdruck und der Wasser-Fußabdruck kurz vorgestellt und in...

  11. Optical spectroscopy of Z Canis Majoris, V1057 Cygni, and FU Orionis - Accretion disks and signatures of disk winds

    Science.gov (United States)

    Welty, Alan D.; Strom, Stephen E.; Edwards, Suzan; Kenyon, Scott J.; Hartmann, Lee W.

    1992-01-01

    High resolution, high SNR optical spectra have been used to investigate the hypothesis that in outburst, FU Ori objects are self-luminous accretion disks whose light dominates at optical and near-IR wavelengths. Strong evidence has been found for linewidth versus wavelength correlation in good agreement with model predictions for Z CMa and V1057 Cyg, but not for FU Ori itself. Linewidth varies continuously with wavelength at optical wavelengths in the former two objects, In the case of FU Ori, it is argued that a combination of strong wind components to spectral lines, and surface gravity possibly being lower than that of supergiants, conceals the underlying linewidth versus wavelength relationship. A marginal correlation is found between linewidth and lower excitation potential in all three objects. Synthetic disk spectra are subtracted from observed spectral, and remarkably good fits are found for all three objects for wavelengths longer than about 5000 A.

  12. Estudo do centro de massa e estabilidade de quatro posturas básicas do Kung-fu Pak Hok

    OpenAIRE

    Miranda,Pedro Jeferson; Brinatti,André Maurício; Silva,Silvio Luiz Rutz da; Godoy,Marino Luiz Michelin

    2016-01-01

    Este trabalho trata da análise dos centros de massa e do cálculo da estabilidade das quatro posturas básicas do Kung Fu Pak Hok. Embora a biomecânica tenha surgido em 1960, a sua aplicação em artes marciais, como no Kung Fu ainda é pouco frequente. Apesar de haver estudos de movimentos do Kung Fu, não há trabalhos sobre o centro de massa e a estabilidade para as posturas mais básicas. Este trabalho como objetivo descrever o centro de massa e a estabilidade das quatro posturas mais básicas do ...

  13. NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

    Science.gov (United States)

    Narayan, Satya; Jaiswal, Aruna S; Sharma, Ritika; Nawab, Akbar; Duckworth, Lizette Vila; Law, Brian K; Zajac-Kaye, Maria; George, Thomas J; Sharma, Jay; Sharma, Arun K; Hromas, Robert A

    2017-08-22

    The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks and overcome treatment effects. Recent evidence suggests a critical role of checkpoint kinase 1 (Chk1) in preventing the replicative stress. Therefore, Chk1 kinase has been a target for developing mono or combination therapeutic agents. In the present study, we have identified a novel orphan molecule NSC30049 (NSC49L) that is effective alone, and in combination potentiates 5-FU-mediated growth inhibition of CRC heterogeneous bulk and FOLFOX-resistant cell lines in culture with minimal effect on normal colonic epithelial cells. It also inhibits the sphere forming activity of CRC stem cells, and decreases the expression levels of mRNAs of CRC stem cell marker genes. Results showed that NSC49L induces 5-FU-mediated S-phase cell cycle arrest due to increased load of DNA damage and increased γ-H2AX staining as a mechanism of cytotoxicity. The pharmacokinetic analysis showed a higher bioavailability of this compound, however, with a short plasma half-life. The drug is highly tolerated by animals with no pathological aberrations. Furthermore, NSC49L showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU. Thus, NSC49L as a single agent or combined with 5-FU can be developed as a therapeutic agent by targeting the Chk1 pathway in 5-FU-resistant CRC heterogeneous bulk and CRC stem cell populations.

  14. Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

  15. Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line.

    Science.gov (United States)

    Kim, Donghwi; Park, Mineon; Jang, Hyunwoong; Hyun, Hoon; Lim, Wonbong

    2018-01-01

    Consistent with cancer stem cell theory, a small fraction of cancer cells, described as cancer stem cells (CSCs), may promote tumor recurrence and anti-cancer drug resistance. Therefore, much effort has been devoted to the development of CSC targeted therapy to vanquish drug resistance. In this study, we have investigated the effect of multiple light-emitting diode (LED) irradiation treatments with conventional anti-cancer drugs on CSC-like oral cancer cells that acquired stemness by ectopic over expression of CD133. To evaluate combined LED irradiation anti-cancer drug effects, we investigated the chemosensitizing effect of 635 nm irradiation on 5-fluorouracil (5FU)-treated KB CD133+ and KB Vec cells, interrogating the underlying molecular mechanisms associated with stemness and apoptosis that are responsible for chemopreventive activity. In addition, combination therapy with LED irradiation and 5-FU treatment was carried out in KB CD133+ and KB Vec cell-inoculated mouse models. LED irradiation of 635 nm inhibited CSC-like properties consistent with a decrease in OCT4 and NANOG protein expression, reducing colony-forming ability. In addition, LED irradiation enhanced 5-FU-induced cytotoxicity and improved 5-FU chemosensitivity in KB CD133+ via enhancement of apoptosis. These findings were validated in vivo, wherein LED irradiation combined with 5-FU treatment inhibited tumor growth in KB CD133+ -inoculated mice. Collectively, our results provide novel evidence for 635 nm irradiation-induced 5-FU chemosensitization of CSC in oral cancer. In addition, this research highlights that 635 nm LED irradiation may serve as an adjunct treatment to conventional chemotherapeutic drugs in patients with oral cancer.

  16. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

    1997-11-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m{sup 2} as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m{sup 2}/d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [Deutsch] Der Standard in der Behandlung weit forgeschrittener, primaer inoperabler Kopf-Hals-Tumoren stellte die Cisplatinhaltige Chemotherapiekombination mit 5-FU dar mit simultan

  17. Clinical research on disciplinarian and character of treatment of zang-fu in syndrome differentiation on insomnia

    Institute of Scientific and Technical Information of China (English)

    凌丽; 薛金伟; 东贵荣

    2005-01-01

    Objective To investigate the therapeutic effect of insomnia with zang-fu in syndrome differentiation. Methods Seventy patients with insomnia according to the diagnostic sequence were randomly divided into two groups, the treatment group and the control group. Two groups received the therapeutic methods of acupuncture in syndrome differentiation and general acupuncture separately. After two courses of treatment and one month's follow-up, therapeutic effect was evaluated through statistical analysis. Resulds The therapeutic effects of the treatment group and the control group have significant differences which have statistical significance. Conclusion Zang-fu in syndrome differentiation may enhance the clinical therapeutic effect of insomnia.

  18. Comparison of force, power, and striking efficiency for a Kung Fu strike performed by novice and experienced practitioners: preliminary analysis.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F; Pacheco, Marcos Tadeu Tavares

    2008-02-01

    This paper presents a comparison of force, power, and efficiency values calculated from Kung Fu Yau-Man palm strikes, when performed by 7 experienced and 6 novice men. They performed 5 palm strikes to a freestanding basketball, recorded by high-speed camera at 1000 Hz. Nonparametric comparisons and correlations showed experienced practitioners presented larger values of mean muscle force, mean impact force, mean muscle power, mean impact power, and mean striking efficiency, as is noted in evidence obtained for other martial arts. Also, an interesting result was that for experienced Kung Fu practitioners, muscle power was linearly correlated with impact power (p = .98) but not for the novice practitioners (p = .46).

  19. Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

    Science.gov (United States)

    Chen, Lijue; She, Xiaodong; Wang, Tao; He, Li; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

    2015-08-01

    Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The

  20. Avaliação da Composição Centesimal, Mineral e Teor de Antocianinas da Polpa de Juçaí (Euterpe edulis Martius

    Directory of Open Access Journals (Sweden)

    Leilson de Oliveira Ribeiro

    2015-07-01

    Full Text Available A polpa de juçaí, fruto da palmeira juçara (Euterpe edulis Martius encontrada nas áreas da Mata Atlântica e a polpa de açaí, fruto da palmeira juçara (Euterpe oleracea Martius cultivado na Floresta Amazônica, foram caracterizadas obtendo assim sua composição centesimal, mineral e também seu teor de antocianinas. Com os resultados obtidos foi possível fazer um estudo comparativo da concentração de antocianinas das duas polpas congeladas e verificar a importância do consumo destes alimentos, classificados como funcionais, devido às propriedades antioxidantes de suas antocianinas no combate dos radicais livres no organismo humano.

  1. Double Exposure and the Climate Gap: Changing demographics and extreme heat in Ciudad Juárez, Mexico

    Science.gov (United States)

    Collins, Timothy W.; McDonald, Yolanda J.; Aldouri, Raed; Aboargob, Faraj; Eldeb, Abdelatif; Aguilar, María de Lourdes Romo; Velázquez-Angulo, Juárez Gilberto

    2013-01-01

    Scholars have recognized a climate gap, wherein poor communities face disproportionate impacts of climate change. Others have noted that climate change and economic globalization may mutually affect a region or social group, leading to double exposure. This paper investigates how current and changing patterns of neighborhood demographics are associated with extreme heat in the border city of Juárez, Mexico. Many Juárez neighborhoods are at-risk to triple exposures, in which residents suffer due to the conjoined effects of the global recession, drug war violence, and extreme heat. Due to impacts of the recession on maquiladora employment and the explosion of drug violence (since 2008), over 75% of neighborhoods experienced decreasing population density between 2000 and 2010 and the average neighborhood saw a 40% increase in the proportion of older adults. Neighborhoods with greater drops in population density and increases in the proportion of older residents over the decade are at significantly higher risk to extreme heat, as are neighborhoods with lower population density and lower levels of education. In this context, triple exposures are associated with a climate gap that most endangers lower socioeconomic status and increasingly older aged populations remaining in neighborhoods from which high proportions of residents have departed. PMID:25642135

  2. The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2014-01-01

    Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

  3. DISENTANGLING THE ENVIRONMENT OF THE FU ORIONIS CANDIDATE HBC 722 WITH HERSCHEL

    International Nuclear Information System (INIS)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel; Pooley, David; Kospal, Agnes; Van Kempen, Tim A.; Van Dishoeck, Ewine; Herczeg, Gregory; Quanz, Sascha P.; Henning, Thomas; Bouwman, Jeroen; Lee, Jeong-Eun; Dunham, Michael M.; Meeus, Gwendolyn; Chen, Jo-Hsin; Guedel, Manuel; Skinner, Stephen L.; Rebull, Luisa M.; Guieu, Sylvain

    2011-01-01

    We analyze the submillimeter emission surrounding the new FU Orionis-type object, HBC 722. We present the first epoch of observations of the active environs of HBC 722, with imaging and spectroscopy from PACS, SPIRE, and HIFI on board the Herschel Space Observatory, as well as CO J = 2-1 and 350 μm imaging (SHARC-II) with the Caltech Submillimeter Observatory. The primary source of submillimeter continuum emission in the region-2MASS 20581767+4353310-is located 16'' south-southeast of the optical flaring source while the optical and near-infrared emission is dominated by HBC 722. A bipolar outflow extends over HBC 722; the most likely driver is the submillimeter source. We detect warm (100 K) and hot (246 K) CO emission in the surrounding region, evidence of outflow-driven heating in the vicinity. The region around HBC 722 itself shows little evidence of heating driven by the new outbursting source itself.

  4. [XI Hong, XI Hong acupuncture school of thought and Xi Hong Fu].

    Science.gov (United States)

    Xu, Chun-Juan; Chen, Rong; Yang, Yong-Shou

    2008-11-01

    XI Hong, a famous acupuncturist in the Southern Song Dynasty, has an important influence and status in history of Chinese acupuncture and moxibustion. After he moved to Linchuan, Jiangxi province, his descendants passed acupuncture from generation to generation. According to records, it was passed to 12 generations. After the tenth generation, it was also passed to apprentices besides descendants, such as accomplished acupuncturists CHEN Hong-gang, LIU Jin and others, forming XI Hong acupuncture school of thought. The poem of acupuncture and moxibustion XI Hong Fu is the representative work about XI Hong academic thought, which was additionally compiled or written by XI Hong's apprentices according to XI Hong academic thought. The poems are of characteristics in acupuncture application and association of acupoints. The academic thought and therapeutic methods of acupuncture in the poems still are widely used in modern clinical acupuncture practice.

  5. Mass loss from pre-main-sequence accretion disks. I - The accelerating wind of FU Orionis

    Science.gov (United States)

    Calvet, Nuria; Hartmann, Lee; Kenyon, Scott J.

    1993-01-01

    We present evidence that the wind of the pre-main-sequence object FU Orionis arises from the surface of the luminous accretion disk. A disk wind model calculated assuming radiative equilibrium explains the differential behavior of the observed asymmetric absorption-line profiles. The model predicts that strong lines should be asymmetric and blueshifted, while weak lines should be symmetric and double-peaked due to disk rotation, in agreement with observations. We propose that many blueshifted 'shell' absorption features are not produced in a true shell of material, but rather form in a differentially expanding wind that is rapidly rotating. The inference of rapid rotation supports the proposal that pre-main-sequence disk winds are rotationally driven.

  6. From specific training to global shift of manual preference in Kung Fu experts.

    Science.gov (United States)

    Maeda, Rodrigo S; Souza, Rosana M; Teixeira, Luis A

    2014-02-01

    Manual preference and intermanual performance asymmetry have been approached from a multidimensional and dynamic perspective. A point of interest from that approach is the role of lateralized motor experiences on handedness. In this study, intermanual performance asymmetry in sport-specific movements and manual preference in daily living tasks were compared between Kung Fu athletes and novices. Analysis of movement time in the performance of interlaterally symmetric and asymmetric movement patterns showed smaller intermanual performance asymmetry in experts. Analysis of manual preference using the Edinburgh Handedness Inventory indicated that experts presented predominantly weak or moderate strength of right hand preference. Novices, conversely, were found to have predominantly strong right hand preference. These results suggest that extensive bimanual training by experts leads to a global shift of manual preference, affecting hand selection in distinct tasks.

  7. Cold CO Gas in the Envelopes of FU Orionis-type Young Eruptive Stars

    Energy Technology Data Exchange (ETDEWEB)

    Kóspál, Á.; Ábrahám, P.; Moór, A. [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 15-17, 1121 Budapest (Hungary); Csengeri, T.; Güsten, R. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Henning, Th. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany)

    2017-02-20

    FU Orionis-type objects (FUors) are young stellar objects experiencing large optical outbursts due to highly enhanced accretion from the circumstellar disk onto the star. FUors are often surrounded by massive envelopes, which play a significant role in the outburst mechanism. Conversely, the subsequent eruptions might gradually clear up the obscuring envelope material and drive the protostar on its way to become a disk-only T Tauri star. Here we present an APEX {sup 12}CO and {sup 13}CO survey of eight southern and equatorial FUors. We measure the mass of the gaseous material surrounding our targets, locate the source of the CO emission, and derive physical parameters for the envelopes and outflows, where detected. Our results support the evolutionary scenario where FUors represent a transition phase from envelope-surrounded protostars to classical T Tauri stars.

  8. Factores asociados con el uso inconsistente de condón en hombres que tienen sexo con hombres de ciudad juárez

    OpenAIRE

    Mendoza-Pérez, Juan C.; Ortiz-Hernández, Luis

    2012-01-01

    Objetivo Analizar los factores asociados con el uso inconsistente de condón en hombres que tienen sexo con hombres (HSH) de Ciudad Juárez, Chihuahua. Material y métodos Se realizó un estudio observacional, transversal y analítico con una muestra por conveniencia (n=186) de HSH de Ciudad Juárez. Las variables independientes fueron: nivel socioeconómico, actitudes hacia del uso del condón, uso de drogas, consumo de alcohol, identidad por orientación sexual y la discrimina­ción por orientación s...

  9. Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine

    1998-01-01

    The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m{sup 2} was administered on days 1 and 7.5-FU at 500 mg/m{sup 2} and VP-16 at 60 mg/m{sup 2} were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/{mu}l) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

  10. Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

    International Nuclear Information System (INIS)

    Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya

    1998-01-01

    The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m 2 was administered on days 1 and 7.5-FU at 500 mg/m 2 and VP-16 at 60 mg/m 2 were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/μl) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

  11. Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol.

    Science.gov (United States)

    Mokhtari, Fatemeh; Bostakian, Anis; Shahmoradi, Zabihollah; Jafari-Koshki, Tohid; Iraji, Fariba; Faghihi, Gita; Hosseini, Sayed Mohsen; Bafandeh, Behzad

    2018-04-01

    Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients. Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy. Final sample included 18 (47%) male patients and age of 35.66±8.04. The performance Er:YAG group was superior in all sites. Reduction in the size of patches was greater in Er:YAG group (p-value=.004). Also, this group showed a higher pigmentation scores in the trial period than control group (p-value<.001). Greater reduction in the size and increase in pigmentation score was seen in Er:YAG group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:AYG could help in reducing complications of long-term topical treatments, achieving faster response, and improving patient adherence. © 2017 Wiley Periodicals, Inc.

  12. Fuels planning: science synthesis and integration; environmental consequences fact sheet 12: Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool

    Science.gov (United States)

    William Elliot; David Hall

    2005-01-01

    The Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool was developed to estimate sediment generated by fuel management activities. WEPP FuMe estimates sediment generated for 12 fuel-related conditions from a single input. This fact sheet identifies the intended users and uses, required inputs, what the model does, and tells the user how to obtain the...

  13. The role of effective mass and hand speed in the performance of kung fu athletes compared with nonpractitioners.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F

    2007-05-01

    The main goal of this article is to quantify the contribution of effective mass (me) and handspeed (shi) on the palm strike performance of kung fu athletes (kung fu group) compared with nonpractitioners (control group). All subjects were asked to strike a basketball. Hand and ball speed (sbf) were determined by high-speed video analysis. The value for me was determined by an equation that does not depend upon postimpact measurement of the hand speed. The results show that kung fu athletes had greater shi (6.67 [SD 1.42] m/s), p = 0.042), higher me (2.62 [SD 0.33] kg, p = 0.004), and greater sbf (9.00 [SD 1.89] m/s), p = 0.004) than the nonpractitioners (5.04 [SD 0.57] m/s, 1.33 [SD 0.19] kg, and 5.72 [SD 0.44] m/s, respectively). Comparing the average values obtained for me and hand and forearm mass (m), it was found that for the control group me is statistically equal to m (p = 0.917), whereas for the kung fu group me is significant greater than m (p = 0.003). It is suggested that for impacts against heavier objects, the effective mass would be the main factor to distinguish a martial arts-trained from an untrained subject.

  14. The Effect of 5 FU on the Expression of Transforming Growth Factor Beta-1 (Tgf-1 in Cultured Tendon Cells

    Directory of Open Access Journals (Sweden)

    Zeynep Karacor Altuntas

    2014-10-01

    Full Text Available This study investigated the effect of the treatment with 1 min exposures to 5-fluorouracil (5-FU  on the expression of TGF-beta 1 in cultured tendon cells. Fibroblasts cultured from the flexor tendons of dog paws were treated with 3 different doses of 5-FU ( control, 5-15-25 mgr /ml for 1 minute.  After 5-FU exposure  the expression of TGF –beta 1 were tested by real time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR at 3rd and 7th days. There were no statistically significant differences in the expression levels of the TGF-b1 gene between the control group and all other groups on day 3 and 7 (p>0.05.However, when the percentage changes in the TGF-BETA1 gene expression on days 3–7 were compared, there were statistically significant differences and this was maximally observed with 89% +12 (p<0.05 in the group treated with 25-mg/ml 5-FU.  We conclude that 1min. 5-FU application may be  sufficient to prevent adhesions in tendon healing by limiting the expression of TGF-BETA1. 

  15. The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

    Directory of Open Access Journals (Sweden)

    Kjellén Elisabeth

    2009-12-01

    Full Text Available Abstract Background In locally advanced rectal cancer, 5-Fluorouracil (5-FU-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties, oxaliplatin has recently been incorporated in many clinical chemoradiation protocols. The aim of this study was to investigate to what extent 5-FU and oxaliplatin influence the radiation (RT induced small bowel mucosal damage when given in conjunction with single or split dose RT. Methods Immune competent balb-c mice were treated with varying doses of 5-FU, oxaliplatin (given intraperitoneally and total body RT, alone or in different combinations in a series of experiments. The small bowel damage was studied by a microcolony survival assay. The treatment effect was evaluated using the inverse of the slope (D0 of the exponential part of the dose-response curve. Results In two separate experiments the dose-response relations were determined for single doses of RT alone, yielding D0 values of 2.79 Gy (95% CI: 2.65 - 2.95 and 2.98 Gy (2.66 - 3.39, for doses in the intervals of 5-17 Gy and 5-10 Gy, respectively. Equitoxic low doses (IC5 of the two drugs in combination with RT caused a decrease in jejunal crypt count with significantly lower D0: 2.30 Gy (2.10 - 2.56 for RT+5-FU and 2.27 Gy (2.08 - 2.49 for RT+oxaliplatin. Adding both drugs to RT did not further decrease D0: 2.28 Gy (1.97 - 2.71 for RT+5-FU+oxaliplatin. A clearly higher crypt survival was noted for split course radiation (3 × 2.5 Gy compared to a single fraction of 7.5 Gy. The same difference was seen when 5-FU and/or oxaliplatin were added. Conclusion Combining 5-FU or oxaliplatin with RT lead to an increase in mucosal damage as compared to RT alone in our experimental setting. No additional reduction of jejunal crypt counts was noted when both drugs were combined with single dose RT. The higher crypt survival with split dose radiation indicates a

  16. Loss of ABCB4 attenuates the caspase-dependent apoptosis regulating resistance to 5-Fu in colorectal cancer.

    Science.gov (United States)

    Hu, Hanqing; Wang, Meng; Guan, Xu; Yuan, Ziming; Liu, Zheng; Zou, Chaoxia; Wang, Guiyu; Gao, Xu; Wang, Xishan

    2018-02-28

    The adenosine triphosphate-binding cassette (ABC) is a large group of proteins involved in material transportation, cellular homeostasis, and closely associated with chemoresistance. ATP-binding cassette protein B4 (ABCB4) is a member of ABCs which has a similar structure to ABCB1, but fewer researches were performed. The present study is aimed to investigate the putative mechanism of ABCB4 in 5-fluorouracil (5-Fu) resistance. Then, we found that ABCB4 was significantly down-regulated in the 5-Fu resistant HCT8 cell lines by polymerase chain reaction (PCR) and Western blot. The knockdown of ABCB4 by small interfering RNA decreased the apoptosis by 5-Fu in resistant HCT8R cell lines without influencing the proliferation. Also, we found a lower expression of cleaved caspase and PARP by Western blot after the knockdown of ABCB4. However, the knockdown of ABCB4 did not influence the proliferation and apoptosis. Furthermore, the histological detection of ABCB4 mRNA level in human colorectal cancer tissues and even in the recurrent tissues after 5-Fu single-agent chemotherapy was employed to provide more concrete evidence that ABCB4 may be a tumor suppressor gene to regulate chemoresistance in colorectal cancer. Moreover, a 109-patient cohort revealed that ABCB4 predicted a poor recurrence-free survival and overall survival. In summary, ABCB4 was down-regulated in the 5-Fu resistant cells and knockdown of ABCB4 alleviated the cell apoptosis and predicts a shorter recurrence-free survival and overall survival. © 2018 The Author(s).

  17. Low Impact Development Intensive Rural Construction Planning in Xu Fu Village Ningbo, China: Planning Review through Rural Resilience Perspective

    Directory of Open Access Journals (Sweden)

    Roosmayri Lovina Hermaputi

    2017-08-01

    Full Text Available Xu Fu Village Ningbo LID Intensive Rural Construction Planning is a cooperation project between Zhejiang University and Ningbo Institute of Technology which named "12th Five-Year National Science and Technology support program-the comprehensive demonstration of the key technology of the beautiful rural construction in the rapid urbanization area of the Yangtze River Delta". This plan focuses on intensive rural construction as part of rural development and construction project that applies the principles of low impact development. Xu Fu Village located in the Yangtze River Delta Region. Currently, the rural growth brings the high impact of development, as a result of rapid urbanization growth arising several issues, such as low land use efficiency, dispersed rural residence, homestead occupies more, rural roads covering over, etc. Meanwhile, Xu Fu village wishes to develop its tourism potential. Thus, the intensive rural construction should be done to avoid the severe effect. The project result hopefully can improve the quality and level of rural residential planning, design, and construction; improve their living environment; save construction land and water use; and improve energy efficiency. The aim of this study is to review the Low Impact Development (LID Intensive Rural Construction in Xu Fu Village, Ningbo City through the rural resilience perspective. This paper will describe the project plan first, then review it through rural resilience perspective. This paper will elaborate the rural resilience theory and then review the rural resiliency through two parts; the first part is identifying rural resilience in rural infrastructure development based on the criteria created by Ayyob S. and Yoshiki Y. (2014, about urban resiliency criteria, and then the second part is reviewing Xu Fu Village resilience through Arup Resilience Qualities (2012, considering three rural resilience domain (economy, ecology, and cultural.

  18. In vivo 19F-MRS observation of 5-FU metabolism in fatty liver induced by choline-deficient diet

    International Nuclear Information System (INIS)

    Otsuka, Hideki; Harada, Masafumi; Nishitani, Hiromu; Koga, Keiko.

    1996-01-01

    Using 19 F-MRS, 5-FU metabolism was investigated in rat fatty liver. Fatty liver was induced by choline-deficient diet (CD diet). This study showed differences in 5-FU metabolism between normal and fatty liver. After laparotomy, a surface coil was placed directly on the liver surface. Spectra were continuously obtained after injection of 5-FU 100 mg/kg body weight via a catheter inserted into femoral vein. We made MRI and 1 H-MRS study to examine the lipid accumulation. Histological study was also performed using HE (hematoxylin-eosin) and oil red stain. The livers of rats fed a CD diet showed very high intensity on T 1 -WI. 1 H-MRS was very useful in deteminating the fat content because the fat ratio demonstrated by 1 H-MRS is well correlated to histological findings. In 19 F-MRS, we recognized the following four peaks: 5-FU, FBAL, Fnct (fluoronucleotide) and FUPA. The decrease of 5-FU was not very apparent, but compared to the normal liver, the formation of Fnct increased and the formation of FBAL was suppressed in fatty liver. The rats fed a CD diet for four weeks showed a higher Fnct peak and lower FBAL peak compared with the results of rats fed a CD diet for two weeks. In a CD diet group, liver cell degeneration and necrotic changes were observed histologically. It is reported that cell degeneration is followed by cell proliferation in fatty liver induced by a choline deficient diet, and the high Fnct peak found in our study may reflect this phenomenon. The high Fnct peak on 19 F-MRS may correspond to recovering reaction from liver injury like fatty liver. (author)

  19. Everybody was Kung-Fu fighting-The beneficial effects of Tai Chi Qigong and self-defense Kung-Fu training on psychological and endocrine health in middle aged and older men.

    Science.gov (United States)

    Walther, A; Lacker, T J; Ehlert, U

    2018-02-01

    Higher age is associated to a variety of physical and mental disorders. Age-related changes in steroid secretion have been suggested to be an underlying mechanism leading to frailty, depression, and sexual dysfunction. However, Tai chi qigong and similar forms of exercise have been shown to improve a great variety of health-related parameters in older individuals. We examined 56 self-reporting healthy men actively practicing Tai chi qigong and/or self-defense Kung-fu and 55 age-matched self-reporting healthy controls. Saliva samples were obtained in a standardized procedure for subsequent quantification of circulating testosterone and cortisol levels. In addition, depressive symptoms, life satisfaction, and sexual health were assessesd via self-report questionnaires. Age was negatively associated with testosterone, while no association emerged for cortisol. Tai chi qigong and/or self-defense Kung-fu training was neither associated with testosterone nor cortisol. More weekly Tai chi qigong and/or self-defense Kung-fu training (4 or more times per week) was instead associated with a lower CT-ratio, less depressive symptoms, and higher life satisfaction compared to individuals, who trained only one to three times per week. More years of Tai chi qigong and/or self-defense Kung-fu training were associated with less depressive symptoms and higher life satisfaction but not with the CT-ratio. No significant associations emerged for Tai chi qigong and/or self-defense Kung-fu training and sexual health. When compared to the age-matched controls, there is a significant effect of Tai chi, qigong and/or self-defense Kung-fu on the CT-ratio. Contrast analyses revealed a significantly lower CT-ratio for the high training load group in contrast to the low training load group. Further, in contrast to the control group, the low training load group exhibits a significantly higher CT-ratio. For depression, contrast analyses revealed a significantly lower level of depression in the

  20. Dažādu navigācijas GPS uztvērēju precizitāte lauka darbos

    OpenAIRE

    Mihailovs, Kalvis

    2010-01-01

    Pasaulē ir pieejams plašs piedāvājums ar dažādiem navigācijas GPS uztvērējiem, to atšķirības ir gan vizuālas, gan tehniskas, gan funkcionālas. GPS uztvērēju ražotāji un izplatītāji sniedz informāciju par GPS uztvērēju precizitāti, taču bieži vien tā ir maldinoša un neatspoguļo patieso horizontālo un vertikālo precizitātes informāciju. Veicot bakalaura darba – dažādu navigācijas GPS uztvērēju precizitāte lauka darbos, mērķis ir noskaidrot dažādu „zemo cenu” navigācijas GPS uztvērēju precizi...

  1. Skolotāju un skolēnu motivācijas mijiedarbība svešvalodas stundās

    OpenAIRE

    Kraģe, Indra

    2010-01-01

    Diplomdarbā ”Skolotāju un skolēnu motivācijas mijiedarbība svešvalodu stundās” pētīta skolotāju motivācija un tās ietekme uz skolēnu motivāciju. Diplomdarba mērķis ir izpētīt motivāciju ietekmējošos faktorus un izzināt, kas skolotājus motivē darbam un kā skolotāju motivācija ietekmē skolēnu motivāciju. Darbs sastāv no divām daļām – teorētiskās un praktiskās. Teorētiskajā daļā sniegts ieskats skolotāju un skolēnu motivācijas psiholoģiskajos un pedagoģiskajos aspektos, savukārt praktiskajā daļā...

  2. Skolotāju uztvertā stresa saistība ar apmierinātību ar darbu

    OpenAIRE

    Dejus, Ilze

    2014-01-01

    Pētījuma „Skolotāju uztvertā stresa saistība ar apmierinātību ar darbu” mērķis, pamatojoties uz teorētisko analīzi, pētīt skolotāju uztvertā stresa saistību ar apmierinātību ar darbu. Pētījuma jautājumi: 1.Vai pastāv statistiski nozīmīga saistība starp skolotāju uztvertā stresa līmeni un apmierinātību ar darbu? 2.Vai pastāv statistiski nozīmīgas atšķirības starp Liepājas 15.vidusskolas un Grobiņas novada skolotāju uztvertā stresa līmeni un apmierinātību ar darbu? Aptaujāti 113 skolot...

  3. N/om, Change, and Social Work: A Recursive Frame Analysis of the Transformative Rituals of the Ju/'hoan Bushmen

    Science.gov (United States)

    Keeney, Hillary; Keeney, Bradford

    2013-01-01

    The Ju/'hoan Bushman origin myth is depicted as a contextual frame for their healing and transformative ways. Using Recursive Frame Analysis, these performances are shown to be an enactment of the border crossing between First and Second Creation, that is, pre-linguistic and linguistic domains of experience. Here n/om, or the presumed creative…

  4. Review of Arciaga, Juárez y Mendoza (Coords. (2013. Introducción a la Psicología Social

    Directory of Open Access Journals (Sweden)

    Ali Lara

    2014-11-01

    Full Text Available Reseña del libro: Salvador Arciaga Bernal, Juana Juárez Romero y Jorge Mendoza Garcia  (coord. (2013. Introducción a la Psicología Social. México: UAM-MAPorrúa. ISBN 978-607-28-0109-7

  5. The city that makes the Maquila: The case of Ciudad Juárez (México)

    OpenAIRE

    Rodríguez Álvarez, Olga Lucía

    2007-01-01

    La configuración del espacio urbano de las ciudades depende en alto grado de los diversos momentos de las actividades productivas y es a partir de ellos que se dan las transformaciones en el espacio urbano. En el caso de Ciudad Juárez, México la inserción de la industria maquiladora de exportación como la "mano invisible" que llevara el desarrollo y progreso a través de la transición de una economía primaria a una secundaria, le imprimió una nueva dinámica y configuración espacial. A casi tre...

  6. Raising Children in a Violent Context: An intersectionality approach to understanding parents' experiences in Ciudad Juárez.

    Science.gov (United States)

    Grineski, Sara E; Hernández, Alma A; Ramos, Vicky

    2013-01-01

    Children and parents' daily lives are rarely highlighted in coverage of drug wars. Using 16 interviews with parents in the Mexican border city of Juárez in 2010, we examine how drug violence impacts families with a focus on intersections of gender and social class. Related to mobility (the first emergent theme), fathers had increased mobility as compared to mothers, which caused different stresses. Material hardships heightened mothers' isolation within the home, and mothers more often had to enforce children's mobility restrictions, which children resisted. Related to employment (the second emergent theme), fathers took on dangerous jobs to provide for the family while mothers had fewer options for informal employment due to violence. In sum, men and women faced different challenges, which were intensified due to class-based material disadvantages. Conformity with traditional gender expectations for behavior was common for men and women, illustrating the normalization of gender inequality within this context.

  7. Some clastic rocks as parent rocks in beech forests of Brezovica - Južni Kučaj

    Directory of Open Access Journals (Sweden)

    Joksimović Vesna

    2003-01-01

    Full Text Available On the large forest areas, where the measures of soil quality improvement are absent or rarely undertaken, the rocks are the sources of a great number of elements in plant nutrition and one of the factors affecting the contents of some elements in plants. The aim of the study is to determine the differences in the contents of Cu, Zn, Mn, Ni, Fe, Cd, Co, Pb and Cr in the beech leaves developed in the same climate conditions, on morphologically similar terrains, composed of different types of sedimentary rocks. This paper presents the study results of the contents of the above elements in argillites, sandstones (grauwackes and microconglomerates occurring as the parent rocks in high beech forests in the region of GJ Bogovina (Brezovica Južni Kučaj and in the leaves of beech developed on these rocks.

  8. Vodenje poslovnih strani in oglaševanje na družbenem omrežju Facebook

    OpenAIRE

    TROŠT, ANAMARIJA

    2017-01-01

    Predstavljena je tema, ki je v današnjem času ena izmed pomembnejših členov v spletnem marketingu. To je vodenje vsebin na družbenem omrežju Facebook ter njihovo oglaševanje. Opisano je, kako določiti ciljno skupino naših potencialnih in želenih strank ter kako personalizirati objavo, da jih bo ta dosegla prek družbenega omrežja. Prek praktičnih primerov iz oglaševanih objav na Facebooku je v delu razvidno, kako lahko vodimo Facebook stran nekega podjetja, da pravilno steče komunikacija me...

  9. Participación ciudadana en las colonias sin agua potable y alcantarillado de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Gustavo Córdova Bojórquez

    2007-01-01

    Full Text Available En este artículo se presenta un análisis de la participación ciudadana en la gestión del agua en 14 colonias que carecen del servicio de agua potable y alcantarillado en Ciudad Juárez, Chihuahua. La metodología consistió en analizar y relacionar las influencias externas e internas de los ciudadanos resultando una participación ciudadana muy baja en la gestión del agua determinada en gran medida por el poco conocimiento sobre el tema, la poca confianza en las instituciones públicas, la mínima disposición de participar en proyectos comunitarios y por la gran influencia que tiene el sistema político en la gestión del servicio.

  10. Rezension von: Ulf Gebken, Söhnke Vosgerau (Hg.: Fußball ohne Abseits. Ergebnisse und Perspektiven des Projekts ‚Soziale Integration von Mädchen durch Fußball‘. Wiesbaden: Springer VS 2014.

    Directory of Open Access Journals (Sweden)

    Robert Claus

    2014-12-01

    Full Text Available Seit 2006 wurden im Rahmen des vom Deutschen Fußball-Bund durchgeführten Modellprojektes „Soziale Integration von Mädchen durch Fußball“ an über 200 Standorten Schul-AGs in sogenannten Brennpunktbezirken aufgebaut. Im vorliegenden Sammelband beleuchten die Autor/-innen ausführlich die Funktion von Sport für die pädagogische Kompetenzvermittlung. Zudem erbringen sie einen umfassenden Projektbericht und leisten ein Plädoyer für die Modernisierung des Verhältnisses zwischen Schule und Vereinen, Lehrplan und Ehrenamt. Somit stellt das Buch, wie auch das Projekt, einen enorm wichtigen Beitrag zur Geschlechtergerechtigkeit im Sport dar. Gleichzeitig jedoch liest sich eine Reihe an Texten etwas zu sperrig für den Bericht einer Praxisforschung, und Begriffe im Feld der ‚Integration’ bleiben schwammig.

  11. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

    Directory of Open Access Journals (Sweden)

    Sare Andalib

    2012-01-01

    Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  12. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design.

    Science.gov (United States)

    Andalib, Sare; Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat

    2012-01-01

    Nanostructured lipid carriers (NLC) are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol), lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of -25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  13. Sequential radiotherapy and chemotherapy using CDDP and 5-FU for advanced head and neck cancer

    International Nuclear Information System (INIS)

    Takamura, Akio; Arimoto, Takuro; Mizoe, Jun-etsu; Tomita, Masayoshi; Kitahara, Toshihiro; Irie, Goro; Matsuoka, Yoshisuke.

    1991-01-01

    From April 1989 to January 1990, nine patients with locally advanced stage IV squamous cell carcinoma of the head and neck underwent combined chemotherapy and radiotherapy (RT). Chemotherapy consisted of two cycles of CDDP (100 mg/m 2 , day 1) + 5-FU (1 g/m 2 , days 1-5, continuous infusion) every five weeks. RT was interdigitated with chemotherapy after the second course of chemotherapy. Each course was initiated two or three days after interrupting chemotherapy. RT was delivered at 65 or 70 Gy for 8 weeks. Of the 7 patients completing the treatment, 29% responded totally, and 43% responded partially. Seven patients died: two due to acute treatment-related toxicity; four due to locoregional progression; and one due to an unrelated cause. Two patients are still alive (10 and 12 months); one is free of tumor, the other has a metastatic bone tumor. Though sequential use of CT might be considered effective for some patients, acute toxicity was moderate to severe and patients with poor performance (≤70%), elderly (≥70 yr) and renal dysfunction (creatinine clearance<80 ml/min) patients must be considered as high risk for treatment by our combined regimen. (author)

  14. [Experimental study on preventing postoperative posterior urethra scar in response to Tablet Fu Kang].

    Science.gov (United States)

    Mo, Jiacong; Wang, Shengyi

    2004-07-01

    To find an effective measurement to prevent and decrease the posterior urethral scar stricture. Twenty New Zealand rabbits were chosen. All the rabbits were made posterior urethra disruption model, and at the same time, the urethra anastomosis operation was performed. Twenty rabbits were divided into two groups after operation at random. One group was treated by Tablet Fu Kang (experimental group), another group was treated by NS (control group). All the rabbits were killed three weeks later, the urethra anastomotic stoma tissue was chosen and stained with Masson. All the figures of slides were inputted into figure analytic system. There were little collagenous fiber, sparsely and arranged in good order in scar tissue of urethra anastomotic stoma in experimental group. The area of collagenous fibers was 117.11 +/- 10.17 microm2 in three visual fields. There were many collagenous fibers, densely,and arranged in disorder in scar tissue of urethra anastomotic stoma in control group, the relative area was 136.43 +/- 15.85 microm2. There was statistic significance when comparing the area of collagenous fiber in two groups (P urethra.

  15. Summary report of Japan-US joint project (TITAN). FuY 2007-2012

    International Nuclear Information System (INIS)

    Okuno, K.; Muroga, T.

    2014-01-01

    This report summarizes the scientific accomplishments achieved through the TITAN Japan-US Collaboration Program. The TITAN collaboration (Tritium, Irradiation and Thermofluid for America and Nippon) has been carried out through six years (FuY 2007-2012) under the collaboration implemented by establishing Annex I to the NIFS-ORNL Agreement on Academic and Scientific Exchange. The TITAN collaboration was established to obtain fundamental understanding for the control of tritium and thermofluid in first wall, blanket and recovery systems with particular emphasis on their interfacial issues. The experiments were designed for testing under conditions specific to fusion, such as intense irradiation, high heat/particle flux, and circulation in a high magnetic field. The results have been applied using integrated modeling to advance the design of tritium and heat control in MFE and IFE systems. This issue is the collection of 34 papers presented at the entitled meeting. All the 34 of the presented papers are indexed individually. (J.P.N.)

  16. Alternative therapy using CDDP/5FU and radiotherapy for nasopharyngeal cancer

    International Nuclear Information System (INIS)

    Shikama, Naoto; Shikano, Masato; Toita, Takafumi; Yuda, Atsushi; Hayashi, Yasuyuki

    2004-01-01

    We conducted a prospective study of an alternative chemoradiation protocol comprising cisplatin (CDDP) (50 mg/m 2 /day, 2 days), 5FU (800 mg/m 2 /day, 5 days) and radiotherapy (66 Gy in 36 fractions) for locally advanced nasopharyngeal cancer (stage II-IV). We treated 67 patients (stage II-III:41 patients, IV:26) using this protocol. Fifty-seven patients (85%) received the full-course, three-cycle chemotherapy. Three-year overall survival rate of all patients was 90.5%, and 3-year disease-free survival rate was 78.3%. The recurrent sites were the primary site in four patients, neck lymph node in two and distant metastasis in eight. Severe myelosuppression (grade 3-4) was observed in half of the patients, and severe mucositis (grade 3-4) in about 30%. Chemotherapy induced severe dysfunction of liver or kidney (grade 3-4) was seen in three patients. This treatment strategy may be very useful, but careful medical management is essential. (author)

  17. A Reactor Development Scenario for the FuZE Sheared-Flow Stabilized Z-pinch

    Science.gov (United States)

    McLean, Harry S.; Higginson, D. P.; Schmidt, A.; Tummel, K. K.; Shumlak, U.; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Golingo, R. P.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.

    2017-10-01

    We present a conceptual design, scaling calculations, and development path for a pulsed fusion reactor based on a flow-stabilized Z-pinch. Experiments performed on the ZaP and ZaP-HD devices have largely demonstrated the basic physics of sheared-flow stabilization at pinch currents up to 100 kA. Initial experiments on the FuZE device, a high-power upgrade of ZaP, have achieved 20 usec of stability at pinch current 100-200 kA and pinch diameter few mm for a pinch length of 50 cm. Scaling calculations based on a quasi-steady-state power balance show that extending stable duration to 100 usec at a pinch current of 1.5 MA and pinch length of 50 cm, results in a reactor plant Q 5. Future performance milestones are proposed for pinch currents of: 300 kA, where Te and Ti are calculated to exceed 1-2 keV; 700 kA, where DT fusion power would be expected to exceed pinch input power; and 1 MA, where fusion energy per pulse exceeds input energy per pulse. This work funded by USDOE ARPA-E and performed under the auspices of Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-734770.

  18. Combination hyperthermia and intraarterial 5-FU for metastatic colon carcinoma to liver

    International Nuclear Information System (INIS)

    Moseley, H.S.; Palmquist, M.

    1984-01-01

    Metastatic colorectal carcinoma to the liver remains a formidable challenge. Responses to chemotherapy are brief and the number of effective drugs is very limited. A phase II trial of hepatic hyperthermia and intraarterial chemotherapy was undertaken to attempt to improve response rates and duration. Patients were given a 10 day course of IA 5-FU at 15 mg/kg. During the infusion hyperthermia was given five times using the BSD Annular Phased Array (APA). Thermistors were placed percutaneously into normal liver and tumor using ultrasound or CT scan guidance. Six patients have been treated. Significant problems in positioning ill patients in the APA were encountered, and there was difficulty also in preventing heating throughout the abdominal cavity. Four patients, all with poor performance status, failed to benefit. One patient had improvement in liver function studies for two months and failed to respond on a repeat course. One patient had a complete response which is continuing over 18 months with a liver scan reverting to normal and CEA returning to normal. These preliminary results are promising and warrant further trials

  19. Electromiographic and kinematic characteristics of Kung Fu Yau-Man palm strike.

    Science.gov (United States)

    Neto, O P; Magini, Marcio

    2008-12-01

    A kinematic and electromyographic analysis of Kung Fu (KF) Yau-Man palm strikes without impact is presented. An empirical model applied to data obtained by a high-speed camera describes the kinematic characteristics of the movement. The electromyographic patterns of the biceps brachii, brachioradialis and triceps brachii muscles were studied during the strike in the time (root mean square) and frequency (wavelet transform) domains. Eight KF practitioners participated in the investigation. A wooden board was placed in front of the subjects, and they were asked to perform the strike imagining a target above the board. The results show that the Yau-Man KF palm strike has very similar kinematic characteristics to a simple moderate speed elbow extension movement. All practitioners positioned themselves in relation to the wooden board in a way to achieve their highest hand speeds in the instant their hands crossed the board. The analyses of the electromyography data shows a well developed muscle coordination of the practitioners in agreement with kinematic results. The results of this paper are important not only for improving the performance of practitioners but also to demonstrate the applicability of KF in the process of motor control development.

  20. Kung fu training improves physical fitness measures in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael R; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 +/- 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37-2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  1. Die Osteonekrose des Fußes: Eine Übersicht

    Directory of Open Access Journals (Sweden)

    Schenk S

    2007-01-01

    Full Text Available Die Osteonekrose (ON am Fuß ist eine heterogene Gruppe von Krankheitsbildern, die sich deutlich hinsichtlich Klinik, Verlauf, Prädilektionsalter und Prognose unterscheiden. Ebenso sind die Ursachen für diese Erkrankungen vielfältig: Neben idiopathischen finden sich auch posttraumatische und postoperative Formen. Seltene Ursachen sind Kollagenosen, Stoffwechselerkrankungen wie Diabetes mellitus und Kortikoidtherapie. ON finden sich gehäuft nach Nierentransplantationen. Je nach Ursache tritt eine ON gehäuft in typischer Lokalisation auf. Idiopathische Formen findet man am Os naviculare pedis – Morbus Köhler 1 (MK1, an den Metatarsaleköpfchen – Morbus Köhler 2, "Freiberg’s disease" (MK2, an den Sesambeinen und an der Apophyse des Calcaneus. Operationsbedingte Fälle sind gehäuft am Metatarsaleköpfchen 1 nach Versorgung eines Hallux valgus lokalisiert, posttraumatische Nekrosen am Talus. In diesem Artikel werden die idiopathischen Formen hinsichtlich Klinik und Therapie näher beleuchtet. Bezüglich der Therapie gibt es konservative und operative Ansätze. Die wissenschaftlichen Daten zur Behandlung von idiopathischen Nekrosen sind spärlich, die Behandlungsstrategien jedoch einheitlich und allgemein anerkannt.

  2. Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer

    Directory of Open Access Journals (Sweden)

    Ankita Gupta

    2015-09-01

    Full Text Available The work was aimed at developing novel enteric coated HPMC capsules (ECHC plugged with 5 Florouracil (5-FU loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content on the dependent variables (Particle size, %EE & % CDR were determined. The optimized microsponges (F4 were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100 and/ or Eudrgit S 100 (Ed-S 100 in different proportions. In vitro release study of ECHC was performed in various release media sequentially SGF for 2 h, followed by SIF for the next 6 h and then in SCF (in the presence and absence of pectinase enzyme for further 16 h. Drug release was retarded on coating with EdS-100 in comparison to blend of EdS-100: EdL-100 coating. The percentage of 5-FU released at the end of 24 h from ECHC 3 was 97.83 ± 0.12% in the presence of pectinase whereas in control study it was 40.08 ± 0.02% drug. The optimized formulation was subjected to in vivo Roentgenographic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon targeted capsules. Pharmacokinetic studies in New Zealand white rabbits were conducted to determine the extent of systemic exposure provided by the developed formulation in comparison to 5-FU aqueous solutions. Thus, enteric coated HPMC capsules plugged with 5-FU loaded microsponges and calcium pectinate beads proved to be promising dosage form for colon targeted drug delivery to treat colorectal cancer.

  3. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer

    International Nuclear Information System (INIS)

    Minsky, Bruce D.; Cohen, Alfred M.; Enker, Warren E.; Saltz, Leonard; Guillem, Jose G.; Paty, Philip B.; Kelsen, David P.; Kemeny, Nancy; Ilson, David; Bass, Joanne; Conti, John

    1997-01-01

    Purpose: We report the local control and survival of two Phase I dose escalation trials of combined preoperative 5-fluorouracil (5-FU), low-dose leucovorin (LV), and radiation therapy followed by postoperative LV/5-FU for the treatment of patients with locally advanced and unresectable rectal cancer. Methods and Materials: A total of 36 patients (30 primary and 6 recurrent) received two monthly cycles of LV/5-FU (bolus daily x 5). Radiation therapy (50.40 Gy) began on day 1 in the 25 patients who received concurrent treatment and on day 8 in the 11 patients who received sequential treatment. Postoperatively, patients received a median of four monthly cycles of LV/5-FU. Results: The resectability rate with negative margins was 97%. The complete response rate was 11% pathologic and 14% clinical for a total of 25%. The 4-year actuarial disease-free survival was 67% and the overall survival was 76%. The crude local failure rate was 14% and the 4-year actuarial local failure rate was 30%. Crude local failure was lower in the four patients who had a pathologic complete response (0%) compared with those who either did not have a pathologic complete response (16%) or who had a clinical complete response (20%). Conclusion: Our preliminary data with the low-dose LV regimen reveal encouraging downstaging, local control, and survival rates. Additional follow-up is needed to determine the 5-year results. The benefit of downstaging on local control is greatest in patients who achieve a pathologic complete response

  4. Producing High-Performance, Stable, Sheared-Flow Z-Pinches in the FuZE project

    Science.gov (United States)

    Golingo, R. P.; Shumlak, U.,; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; University of Washington (UW) Collaboration; Lawrence Livermore National Laboratory (LLNL) Collaboration

    2017-10-01

    The Fusion Z-Pinch Experiment (FuZE) has made significant strides towards generating high-performance, stable Z-pinch plasmas with goals of ne = 1018 cm-3 and T =1 keV. The Z-pinch plasmas are stabilized with a sheared axial flow that is driven by a coaxial accelerator. The new FuZE device has been constructed and reproduces the major scientific achievements the ZaP project at the University of Washington; ne = 1016 cm-3,T = 100 eV, r20 μs. These parameters are measured with an array of magnetic field probes, spectroscopy, and fast framing cameras. The plasma parameters are achieved using a small fraction of the maximum energy storage and gas injection capability of the FuZE device. Higher density, ne = 5×1017 cm-3, and temperature, T = 500 eV, Z-pinch plasmas are formed by increasing the pinch current. At the higher voltages and currents, the ionization rates in the accelerator increase. By modifying the neutral gas profile in the accelerator, the plasma flow from the accelerator is maintained, driving the flow shear. Formation and sustainment of the sheared-flow Z-pinch plasma will be discussed. Experimental data demonstrating high performance plasmas in a stable Z-pinches will be shown. This work is supported by an award from US ARPA-E.

  5. TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.

    Science.gov (United States)

    Fariña-Sarasqueta, A; Gosens, M J E M; Moerland, E; van Lijnschoten, I; Lemmens, V E P P; Slooter, G D; Rutten, H J T; van den Brule, Adriaan J C

    2011-08-01

    Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy. 251 patients diagnosed with stage III colon carcinoma treated with surgery followed by 5-FU based adjuvant therapy were selected. The variable number of tandem repeats (VNTR) and the single nucleotide polymorphism (SNP) in the 5'untranslated region of the TS gene were genotyped. There was a positive association between tumor T stage and the VNTR genotypes (p = 0.05). In both univariate and multivariate survival analysis no effects of the studied polymorphisms on survival were found. However, there was an association between both polymorphisms and age. Among patients younger than 60 years, the patients homozygous for 2R seemed to have a better overall survival, whereas among the patients older than 67 this longer survival was seen by the carriers of other genotypes. We conclude that the TS VNTR and SNP do not predict response to 5-FU therapy in patients with stage III colon carcinoma. However, age appears to modify the effects of TS polymorphisms on survival.

  6. Spectral energy distribution analysis of class I and class II FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Gramajo, Luciana V.; Gómez, Mercedes [Observatorio Astronómico, Universidad Nacional de Córdoba, Argentina, Laprida 854, 5000 Córdoba (Argentina); Rodón, Javier A., E-mail: luciana@oac.uncor.edu, E-mail: mercedes@oac.uncor.edu, E-mail: jrodon@eso.org [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago 19 (Chile)

    2014-06-01

    FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

  7. Physiological, performance, and nutritional profile of the Brazilian Olympic Wushu (kung-fu) team.

    Science.gov (United States)

    Artioli, Guilherme Giannini; Gualano, Bruno; Franchini, Emerson; Batista, Rafael Novaes; Polacow, Viviane Ozores; Lancha, Antonio Herbert

    2009-01-01

    The purpose of the present study was to determine physiological, nutritional, and performance profiles of elite Olympic Wushu (kung-fu) athletes. Ten men and four women elite athletes took part in the study. They completed the following tests: body composition, nutritional assessment, upper-body Wingate Test, vertical jump, lumbar isometric strength, and flexibility. Blood lactate was determined at rest and after the Wingate Test. Blood lactate was also determined during a training session (combat and Taolu training). We found low body fat (men: 9.5 +/- 6.3%; women: 18.0 +/- 4.8%), high flexibility (sit-and-reach-men: 45.5 +/- 6.1 cm; women: 44.0 +/- 6.3 cm), high leg power (vertical jump-men: 37.7 +/- 8.4 cm; women: 32.3 +/- 1.1 cm), high lumbar isometric strength (men: 159 +/- 13 cm; women: 94 +/- 6 cm), moderate arm mean and peak power (Wingate Test-men: 4.1 +/- 0.4 and 5.8 +/- 0.5 Wxkg, respectively; women: 2.5 +/- 0.3 and 3.4 +/- 0.3 W.kg, respectively), and elevated blood lactate after the Wingate Test (men: 10.8 +/- 2.0 mmolxL; women: 10.2 +/- 2.0 mmolxL) and during training (combat: 12.0 +/- 1.8 mmolxL; Taolu: 7.7 +/- 3.3 mmolxL). Men athletes consume a high-fat, low-carbohydrate diet, whereas women consume a moderate, high-carbohydrate diet. Energy consumption was markedly variable. In conclusion, Olympic Wushu seems to be a highly anaerobic-dependent combat sport. Low body fat, high flexibility, leg anaerobic power, isometric strength, and moderately high arm anaerobic power seem to be important for successful competitive performance.

  8. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico

    Directory of Open Access Journals (Sweden)

    Bird Y

    2016-06-01

    Full Text Available Yelena Bird,1 Hugo Staines-Orozco2 1School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada; 2Institute of Biomedical Sciences, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Calle Estocolmo, Ciudad Juárez, Chihuahua, Mexico Background: Youth smoking trends among Latin American countries, including Mexico, are on the rise. Notably, although the high prevalence of smoking in teens has been well documented in the literature, few studies have evaluated the impact of smoking and secondhand smoke (SHS exposure on their respiratory system.  Objective: To investigate the effects of smoking and SHS exposure on the respiratory health and lung function among eighth-grade students in Juárez, Mexico. Methods: A cross-sectional study was undertaken on a sample of convenience. The study outcomes centered on evaluating 300 students’ lung function by spirometry (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC], and forced mid-expiratory flow rate [FEF25%–75%] and their respiratory health (smoking behavior and SHS exposure by their self-reported responses to a standardized respiratory questionnaire. The study outcomes were compared among three distinct groups: 1 nonsmokers/nonexposed to SHS; 2 nonsmokers/exposed to SHS; and 3 smokers. Results: The majority of the study participants were 14 years old (85%, females (54%, who attended eighth grade in a public school setting (56%. Approximately, half reported being of low socioeconomic status (49% and nonsmokers/exposed to SHS (49%. The lung function parameters of smokers were found to be lower (FEV1 =62.88±10.25; FEV1/FVC =83.50±14.15; and FEF25%–75% =66.35±12.55 than those recorded for the nonsmokers/exposed to SHS (FEV1 =69.41±11.35; FEV1/FVC =88.75±15.75; and FEF25%–75% =78.90±14.65 and significantly reduced when compared to the nonsmokers/nonexposed to SHS (FEV1 =79.14±13

  9. Post-operative chemosensitized radiation with modulated 5-fluorouracil (5-FU) following resection of adenocarcinoma of the esophagus and esophagogastric (EG) junction

    International Nuclear Information System (INIS)

    Kurtzman, S.M.; Whittington, R.; Vaughn, D.; Rosato, E.F.; Haller, D.G.

    1995-01-01

    Purpose: To evaluate the survival and toxicity of post-operative chemosensitized radiation with modulated 5-FU chemotherapy in patients with resected adenocarcinomas of the esophagus and EG junction. Materials and Methods: One hundred and ninety-two patients with localized adenocarcinomas of the esophagus and EG junction were treated with single or combined modality therapy. The results in the first 165 patients treated between 1972 and 1989 demonstrated that survival was improved with chemosensitized radiation therapy following surgical resection. In the final group of patients treated between 1985 and 1989 a 96 hour inpatient 5-FU infusion was used to provide chemosensitization in those patients. Twenty-seven patients have been treated between January 1990 and December 1994 using a new outpatient regimen with modulated 5-FU chemotherapy for chemosensitization. Radiation and chemotherapy commenced within 6 weeks of surgery. The dose of radiation was 54 Gy in patients with no residual tumor, and 59.4 to 63.0 Gy in patients with positive margins or residual tumor. Modulated 5-FU using bolus 5-FU with Leukovorin +/-α-interferon (α-IFN) was given during the first and fifth week of radiation. Results: Median follow-up of surviving patients treated with modulated 5-FU is 15 months (max - 46 mos). Survival is 71% at 1 year, 45% at 2 years and 39% at 3 years. This compares favorably with the survival with 5-FU infusion, 75% - 1 year, 35% - 2 year, and 10% - 3 year. The toxicity of modulated 5-FU was no different from that observed in patients treated with 5-FU infusion. Three patients treated with modulated 5-FU leukovorin and α-IFN required intravenous hydration, and two patients experienced grade 3 leukopenia. There were two radiation related events in these patients, one case of radiation pneumonitis and one patient with pericarditis. Conclusions: Based on this experience, aggressive therapy of adenocarcinomas of the esophagus and EG junction with surgery and

  10. Preoperative Capecitabine and Pelvic Radiation in Locally Advanced Rectal Cancer-Is it Equivalent to 5-FU Infusion Plus Leucovorin and Radiotherapy?

    International Nuclear Information System (INIS)

    Chan, Alexander K.; Wong, Alfred O.; Jenken, Daryl A.

    2010-01-01

    Purpose: The aim of this retrospective case-matching study was to compare the treatment outcomes and acute toxicity of preoperative radiotherapy (RT) with capecitabine vs. preoperative RT with intermittent 5-fluorouracil (5-FU) infusion, leucovorin, and mitomycin C in rectal cancer. Methods and Materials: We matched 34 patients who were treated with preoperative concurrent capecitabine and 50 Gy of RT by their clinical T stage (T3 or T4) and the tumor location (≤7 cm or >7 cm from the anal verge) with another 68 patients who were treated with preoperative intermittent 5-FU infusion, leucovorin, mitomycin C, and 50 Gy of RT for a comparison of the pathologic tumor response, local control, distant failure, and survival rates. Results: The pathologic complete response rate was 21% with capecitabine and 18% with 5-FU and leucovorin (p = 0.72). The rate of T downstaging after chemoradiation was 59% for both groups. The rate of sphincter-sparing resection was 38% after capecitabine plus RT and 43% after 5-FU plus RT (p = 0.67). At 3 years, there was no significant difference in the local control rate (93% for capecitabine and 92% for 5-FU and leucovorin), relapse-free rate (74% for capecitabine and 73% for 5-FU and leucovorin), or disease-specific survival rate (86% for capecitabine and 77% for 5-FU and leucovorin). The acute toxicity profile was comparable, with little Grade 3 and 4 toxicity. Conclusions: When administered with concurrent preoperative RT, both capecitabine and intermittent 5-FU infusion with leucovorin modulation provided comparable pathologic tumor response, local control, relapse-free survival, and disease-specific survival rates in rectal cancer.

  11. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

    Energy Technology Data Exchange (ETDEWEB)

    Gaballah, Hanaa H., E-mail: hanaahibishy@hotmail.com [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Gaber, Rasha A. [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Mohamed, Darin A. [Histopathology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt)

    2017-02-01

    Background: Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. Aim: This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). Methods: Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC + 5-FU, SEC + apigenin, SEC + 5-FU + apigenin. Beclin-1 and caspases 3, 9 and JNK activities were estimated by ELISA; mRNA expression levels of the antiapoptotic gene Mcl-1 were estimated using quantitative real-time RT-PCR, while tissue malondialdehyde (MDA), glutathione peroxidase and total antioxidant capacity were evaluated spectrophotometrically. A part of the tumor was examined for histopathological and Ki-67 immunohistochemistry analysis. Results: 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. In conclusion: The combination of 5-FU and apigenin had a greater effect than each of 5-FU or apigenin alone against solid Ehrlich carcinoma in mice. - Highlights: • Apigenin potentiated 5-FU cytotoxicity in EAC solid tumor models in vivo. • It acted via autophagy stimulation, downregulating MCL-1 and Ki-67 expression. • It caused JNK activation and ROS accumulation; resulted in tumor growth inhibition. • Apigenin can be used as a co-adjuvant agent in cancer therapy.

  12. [Study of the immunological mechanism of anti-tumor effects of 5-FU by establishing EL4 tumor-bearing mouse models].

    Science.gov (United States)

    Li, Mo-Lin; Li, Chuan-Gang; Shu, Xiao-Hong; Li, Ming-Xia; Jia, Yu-Jie; Qin, Zhi-Hai

    2007-11-01

    To investigate the immunological mechanism of anti-tumor effect of 5-FU by establishing lymphoma EL4 tumor-bearing mouse models in wild type C57BL/6 mice and nude C57BL/6 mice, respectively. The mouse lymphoma EL4 cells were inoculated subcutaneously into wild type C57BL/6 mice (immune-competent mice). Twelve days later, 5-FU of different doses was administered intraperitoneally to treat these wild type C57BL/6 tumor-bearing mice. The size of tumors in the wild type C57BL/6 mice was observed and recorded to explore the minimal dose of 5-FU that could cure the tumor-bearing mice. Then the same amount of EL4 tumor cells was inoculated subcutaneously into wild type C57BL/6 mice and nude C57BL/6 mice (T cell-deficient mice) simultaneously, which had the same genetic background of C57BL/6. Twelve days later, 5-FU of the minimal dose was given intraperitoneally to treat both the wild type and nude C57BL/6 tumor-bearing mice. The size of tumors in the two different types of mice was observed and recorded. A single dose of 5-FU (75 mg/kg) cured both the EL4 tumor-bearing wild type C57BL/6 mice and the EL4 tumor-bearing nude C57BL/6 mice in the first week. Two weeks after 5-FU treatment, all of the nude mice died of tumor relapse while most of the wild type C57BL/6 mice were fully recovered. A single dose of 5-FU has marked anti-tumor effects on lymphoma EL4 tumor-bearing C57BL/6 mice with or without T lymphocytes. The relapse of tumors after 5-FU treatment might be related to the function of T lymphocytes.

  13. Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU.

    Science.gov (United States)

    Asadi, Nahideh; Annabi, Nasim; Mostafavi, Ebrahim; Anzabi, Maryam; Khalilov, Rovshan; Saghfi, Siamak; Mehrizadeh, Masoud; Akbarzadeh, Abolfazl

    2018-02-22

    Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe 3 O 4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.

  14. Conceito, juízo e silogismo: Introdução à lógica do conceito de Hegel

    Directory of Open Access Journals (Sweden)

    Christian Iber

    2017-02-01

    Full Text Available O que é um conceito no sentido de Hegel é, atualmente, algo praticamente desconhecido. Como exemplo de um conceito, a Filosofia Moderna da Linguagem apresenta aproximadamente o conceito de pílula anticoncepcional. Nenhuma mulher, nem mesmo uma admiradora da dialética, compreenderia, por exemplo, se, no médico passando a receita, o conceito de pílula anticoncepcional começasse a correr e no farmacêutico transmutasse no seu oposto. Ninguém admitiria que com os conceitos fundamentais de nossa vida joga-se de tal maneira (Wilhelm E. Essler. A crítica à doutrina hegeliana do juízo, que se tornou uma repreensão standard, reza que ele confundiria a cópula com a identidade: A parte da dialética de Hegel parece geralmente repousar no equívoco de dois significados da palavra é (Bertrand Russel. E, em relação à doutrina de Hegel do silogismo, o hegeliano Vittorio Hösle chega à seguinte averiguação fulminante: Em medida ainda mais alta do que a lógica do juízo de Hegel, sua lógica do silogismo tem que valer como ultrapassada. Este artigo objetiva iluminar o sentido racional e o conteúdo crítico da teoria de Hegel do conceito, do juízo e do silogismo.

  15. Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project.

    Science.gov (United States)

    Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D'Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

    2016-06-02

    In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site.

  16. Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project

    Directory of Open Access Journals (Sweden)

    Christos Antonopoulos

    2016-06-01

    Full Text Available In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes, and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site.

  17. Bolívar, Juárez y Guevara: apuntes sobre socialización e identidad

    Directory of Open Access Journals (Sweden)

    Pedro António Da Silva-Abrantes

    2011-01-01

    Full Text Available A través de un análisis de las biografías de Bolívar, Juárez y Guevara, se discute la compleja relación entre socialización, identidad y cambio social, en los tiempos modernos. Tras un debate inicial sobre los usos y limitaciones del método biográfico, se busca comprender la vida de los tres personajes históricos, utilizando y buscando explorar algunas teorías sociológicas recientes. Se concluye que, en los tres casos, la integración desde temprana edad a distintos entornos sociales y, en particular, a procesos educativos múltiples resultantes de distintos movimientos político-pedagógicos, ocurrencias biográficas imprevistas e incluso a partir de cierta edad, de un trabajo consciente de los actores sobre sí mismos, permitió la formación de un habitus de fusión. Se argumenta que esta identidad peculiar personificó (y promovió la unificación de fuerzas sociales en conflicto.

  18. Coverage of violence in risk areas: case of the Ciudad Juárez´Journalist Association

    Directory of Open Access Journals (Sweden)

    José Luis González-Esteban

    2016-11-01

    Full Text Available This research analyzes the situation of journalism in a high risk area, Ciudad Juarez, Mexico. The analysis is based on the knowledge and analysis of the training activity, violence and corruption denounced by Juarez Journalists Association, founded and run by women journalists. A meeting with journalists of the association and in-depth interviews are the main methodological tools to understand the meaning and value of this group of juarenses journalists. In the same way this article analyzes, through a quantitative methodology, the strategy of activism and the international projection of the association through their social networks. In addition, research is completed with a content analysis about the prevalence and significance of the ‘red note’ in El Diario de Juárez, the main newspaper in this border area, which even has a delegation in the US city of El Paso. Coverage of violence in high risk areas gives a special value to journalism in newspapers like the aforementioned and corporate work of this group of juarenses journalists.

  19. The compound Chinese medicine "Kang Fu Ling" protects against high power microwave-induced myocardial injury.

    Science.gov (United States)

    Zhang, Xueyan; Gao, Yabing; Dong, Ji; Wang, Shuiming; Yao, Binwei; Zhang, Jing; Hu, Shaohua; Xu, Xinping; Zuo, Hongyan; Wang, Lifeng; Zhou, Hongmei; Zhao, Li; Peng, Ruiyun

    2014-01-01

    The prevention and treatment of Microwave-caused cardiovascular injury remains elusive. This study investigated the cardiovascular protective effects of compound Chinese medicine "Kang Fu Ling" (KFL) against high power microwave (HPM)-induced myocardial injury and the role of the mitochondrial permeability transition pore (mPTP) opening in KFL protection. Male Wistar rats (100) were divided into 5 equal groups: no treatment, radiation only, or radiation followed by treatment with KFL at 0.75, 1.5, or 3 g/kg/day. Electrocardiography was used to Electrophysiological examination. Histological and ultrastructural changes in heart tissue and isolated mitochondria were observed by light microscope and electron microscopy. mPTP opening and mitochondrial membrane potential were detected by confocal laser scanning microscopy and fluorescence analysis. Connexin-43 (Cx-43) and endothelial nitric oxide synthase (eNOS) were detected by immunohistochemistry. The expression of voltage-dependent anion channel (VDAC) was detected by western blotting. At 7 days after radiation, rats without KFL treatment showed a significantly lower heart rate (P<0.01) than untreated controls and a J point shift. Myocyte swelling and rearrangement were evident. Mitochondria exhibited rupture, and decreased fluorescence intensity, suggesting opening of mPTP and a consequent reduction in mitochondrial membrane potential. After treatment with 1.5 g/kg/day KFL for 7 d, the heart rate increased significantly (P<0.01), and the J point shift was reduced flavorfully (P<0.05) compared to untreated, irradiated rats; myocytes and mitochondria were of normal morphology. The fluorescence intensities of dye-treated mitochondria were also increased, suggesting inhibition of mPTP opening and preservation of the mitochondrial membrane potential. The microwave-induced decrease of Cx-43 and VDAC protein expression was significantly reversed. Microwave radiation can cause electrophysiological, histological and

  20. The compound Chinese medicine "Kang Fu Ling" protects against high power microwave-induced myocardial injury.

    Directory of Open Access Journals (Sweden)

    Xueyan Zhang

    Full Text Available BACKGROUND: The prevention and treatment of Microwave-caused cardiovascular injury remains elusive. This study investigated the cardiovascular protective effects of compound Chinese medicine "Kang Fu Ling" (KFL against high power microwave (HPM-induced myocardial injury and the role of the mitochondrial permeability transition pore (mPTP opening in KFL protection. METHODS: Male Wistar rats (100 were divided into 5 equal groups: no treatment, radiation only, or radiation followed by treatment with KFL at 0.75, 1.5, or 3 g/kg/day. Electrocardiography was used to Electrophysiological examination. Histological and ultrastructural changes in heart tissue and isolated mitochondria were observed by light microscope and electron microscopy. mPTP opening and mitochondrial membrane potential were detected by confocal laser scanning microscopy and fluorescence analysis. Connexin-43 (Cx-43 and endothelial nitric oxide synthase (eNOS were detected by immunohistochemistry. The expression of voltage-dependent anion channel (VDAC was detected by western blotting. RESULTS: At 7 days after radiation, rats without KFL treatment showed a significantly lower heart rate (P<0.01 than untreated controls and a J point shift. Myocyte swelling and rearrangement were evident. Mitochondria exhibited rupture, and decreased fluorescence intensity, suggesting opening of mPTP and a consequent reduction in mitochondrial membrane potential. After treatment with 1.5 g/kg/day KFL for 7 d, the heart rate increased significantly (P<0.01, and the J point shift was reduced flavorfully (P<0.05 compared to untreated, irradiated rats; myocytes and mitochondria were of normal morphology. The fluorescence intensities of dye-treated mitochondria were also increased, suggesting inhibition of mPTP opening and preservation of the mitochondrial membrane potential. The microwave-induced decrease of Cx-43 and VDAC protein expression was significantly reversed. CONCLUSION: Microwave radiation can

  1. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

    Directory of Open Access Journals (Sweden)

    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  2. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Glimelius, B; Sørbye, H; Balteskard, L

    2008-01-01

    not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

  3. Electromyographic Study of a Sequence of Yau-Man Kung Fu Palm Strikes with and without Impact.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Pacheco, Marcos T T

    2007-01-01

    IN MARTIAL ARTS AND CONTACT SPORTS, STRIKES ARE OFTEN TRAINED IN TWO DIFFERENT WAYS: with and without impacts. This study aims to compare the electromyographical activity (EMG) of the triceps brachii (TB), biceps brachii (BB) and brachioradialis (BR) muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms) and frequency (wavelet) domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar. Key pointsEMG analysis of a sequence of Kung Fu strikes demonstrates higher Triceps Brachii and Brachioradialis muscle activity for strikes with impact than strikes without impact.An original reliable method for quantifying EMG wavelet transform results is presented.EMG wavelet power spectra describe muscle roles during a Kung Fu sequence of strikes.

  4. MULTIWAVELENGTH OBSERVATIONS OF V2775 Ori, AN OUTBURSTING PROTOSTAR IN L 1641: EXPLORING THE EDGE OF THE FU ORIONIS REGIME

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, William J.; Megeath, S. Thomas; Kounkel, Marina [Department of Physics and Astronomy, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606 (United States); Tobin, John J. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Stutz, Amelia M.; Henning, Thomas [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Ali, Babar [NHSC/IPAC/Caltech, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Remming, Ian; Manoj, P. [Department of Physics and Astronomy, 500 Wilson Boulevard, University of Rochester, Rochester, NY 14627 (United States); Stanke, Thomas [ESO, Karl-Schwarzschild-Strasse 2, D-85748 Garching bei Muenchen (Germany); Osorio, Mayra [Instituto de Astrofisica de Andalucia, CSIC, Camino Bajo de Huetor 50, E-18008, Granada (Spain); Wilson, T. L., E-mail: wfische@utnet.utoledo.edu [Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375 (United States)

    2012-09-01

    Individual outbursting young stars are important laboratories for studying the physics of episodic accretion and the extent to which this phenomenon can explain the luminosity distribution of protostars. We present new and archival data for V2775 Ori (HOPS 223), a protostar in the L 1641 region of the Orion molecular clouds that was discovered by Caratti o Garatti et al. to have recently undergone an order-of-magnitude increase in luminosity. Our near-infrared spectra of the source have strong blueshifted He I {lambda}10830 absorption, strong H{sub 2}O and CO absorption, and no H I emission, all typical of FU Orionis sources. With data from the Infrared Telescope Facility, the Two Micron All Sky Survey, the Hubble Space Telescope, Spitzer, the Wide-field Infrared Survey Explorer, Herschel, and the Atacama Pathfinder Experiment that span from 1 to 70 {mu}m pre-outburst and from 1 to 870 {mu}m post-outburst, we estimate that the outburst began between 2005 April and 2007 March. We also model the pre- and post-outburst spectral energy distributions of the source, finding it to be in the late stages of accreting its envelope with a disk-to-star accretion rate that increased from {approx}2 Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1} to {approx}10{sup -5} M{sub Sun} yr{sup -1} during the outburst. The post-outburst luminosity at the epoch of the FU Orionis-like near-IR spectra is 28 L{sub Sun }, making V2775 Ori the least luminous documented FU Orionis outburster with a protostellar envelope. The existence of low-luminosity outbursts supports the notion that a range of episiodic accretion phenomena can partially explain the observed spread in protostellar luminosities.

  5. Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-FU) for locally advanced squamous cell carcinoma of the esophagus

    International Nuclear Information System (INIS)

    Kubo, Naoshi; Morimoto, Junya; Tanaka, Hiroaki

    2009-01-01

    Concurrent chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is the standard treatment for unresectable locally advanced esophageal carcinoma. Although this regimen has been widely accepted in Japan, the adverse effect of CDDP such as gastrointestinal and renal toxicity may sometimes be the cause of interruption of the treatment, especially among the elderly patients. Cis-diammine-glycolatoplatinum (nedaplatin: CDGP) is a new platinum agent, which was developed with the aim of decreasing renal and gastrointestinal toxicities but maintaining the effectiveness of CDDP. We reported the efficacy and safety of CRT using CDGP and 5-FU for locally advanced squamous cell carcinoma of the esophagus. Between January 2001 and December 2007, 65 patients with locally advanced esophageal cancer (39 patients with unresectable tumor (cT4) and 26 patients with distant lymphnode or bulky lymphnode metastasis) were eligible and given informed consent and cared by the Department of Surgical Oncology of Osaka City University. Patients received a continuous infusion of 5-FU (250 mg/body) on days 1-21. CDGP was administered at the dose of 10 mg/body by bolus infusion for 1 hour on days 1-5, 8-12 and 15-19 just before radiotherapy. Radiotherapy was delivered in 1.8 Gy fractions, 5 days/week for 4 weeks. For the effective cases of CRT, a surgical resection was followed subsequently and an additional radiotherapy at the dose of 20 Gy was performed for non-effective cases. Complete or partial response was achieved in 46 patients (71%). Hematologic toxicities such as grades 3 and 4 leucocytopenia developed in 19 patients and thrombocytopenia developed in 20 patients, which were well tolerated by conservative therapy. Gastrointestinal and renal toxicities were developed in only a few patients. There was no CRT-related death. Of all 65 patients, 25 patients underwent a surgical resection while 19 patients could receive a curative resection (R0 operation). In the resected

  6. Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.

    Science.gov (United States)

    Yu, Chen; Liu, Shen-Lin; Qi, Ming-Hao; Zou, Xi; Wu, Jian; Zhang, Jing

    2015-02-01

    Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants, Agrimonia pilosa Ledeb ., Patrinia scabiosaefolia and Solanum nigrum L . GCFF has demonstrated clinical efficacy in the treatment of colon cancer. At present, 5-fluorouracil (5-FU) is the primary active chemotherapeutic agent used for treating colon cancer. Using median-effect and apoptosis analyses, fluorescence microscopy and western blotting, the present study analyzed the association between GCFF and 5-FU in the human colon adenocarcinoma LoVo cell line. The effect of GCFF on the expression of chemotherapeutic agent-associated genes was also investigated. The results of the synergistic analysis revealed that GCFF exhibited a significant effect upon 5-FU-associated cytotoxicity within the LoVo cell line. This effect was observed over a broad dose-inhibition range (5-95%), but was particularly significant in the lower concentrations. The flow cytometry results revealed that low doses of GCFF or 5-FU induced S-phase arrest, as did a low-dose combination of the two drugs. After 48 h, GCFF significantly suppressed the expression levels of the chemotherapeutic agent resistance-associated genes within the colon cancer cells. The western blot analysis revealed that the combined effects of 5-FU and GCFF were due to a regulation of the B-cell lymphoma-2 family of proteins. The findings of the present study suggested that GCFF, when combined with 5-FU, has the potential to be a novel, chemotherapeutic compound for the treatment of colon cancer.

  7. Etnoecologia e etnobotânica da palmeira juçara (Euterpe edulis Martius em comunidades quilombolas do Vale do Ribeira, São Paulo Ethnoecology and ethnobotany of the juçara palm (Euterpe edulis Martius in "quilombola" communities of the Ribeira River Valley, São Paulo

    Directory of Open Access Journals (Sweden)

    Renata Moreira Barroso

    2010-06-01

    Full Text Available As comunidades quilombolas são consideradas comunidades negras rurais formadas por descendentes de africanos escravizados. No Vale do Ribeira, uma das regiões mais pobres do estado de São Paulo, estas comunidades vivem da agricultura de subsistência e principalmente da coleta do palmito juçara para complemento da renda familiar. A palmeira juçara possui importante papel ecológico e econômico para a Floresta Atlântica e para as comunidades rurais locais. O objetivo geral deste trabalho foi investigar aspectos etnoecológicos e etnobotânicos da palmeira juçara (Euterpe edulis Martius em comunidades quilombolas do Vale do Ribeira, SP. A investigação se deu em sete comunidades quilombolas através da aplicação de 25 entrevistas semi-estruturadas e da realização de uma oficina de identificação dos animais consumidores de frutos da palmeira. Também foram realizadas coletas e identificação de visitantes florais. Os quilombolas entrevistados demonstraram um detalhado conhecimento ecológico local sobre a palmeira juçara, principalmente a relação da biodiversidade animal associada à espécie. Neste trabalho a etnoecologia e a etnobotânica mostram-se ferramentas importantes no levantamento participativo do conhecimento ecológico local do E. edulis que pode ser considerado no manejo e na conservação da espécie na Floresta Atlântica."Quilombola" communities are distributed all over Brazil. They are composed of the descendents of African slaves. In the Ribeira River Valley, one of the poorest regions in São Paulo state, they practice subsistence agriculture and extract plant resources from the environment, especially the juçara palm (Euterpe edulis Martius, a species that contributes to "quilombola" income. The juçara palm has special ecological and economic importance for "quilombolas". The main aim of this study was to investigate ethnobotanical and ethnoecological aspects of the juçara palm in "quilombola" communities

  8. La estructura espacial urbana y accesibilidad diferenciada a centros de empleo en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    César M. Fuentes Flores

    2009-01-01

    Full Text Available Existen disparidades intraurbanas en los tiempos de traslado del viaje al trabajo en transporte público y privado, producto de una accesibilidad diferenciada a los centros de empleo en Ciudad Juárez, Chihuahua; el objetivo del artículo es explicarlas. La metodología empleada es el análisis espacial, además se elaboraron cuatro modelos de regresión simple estimados mediante la técnica de mínimos cuadrados ordinarios (MCO. Las variables se construyeron con información de la Encuesta de origen-destino de 1997, el XII Censo general de población y vivienda de 2000 y el XIII Censo económico de 1999, a nivel del área geográfica básica (AGEB. Los resultados de los modelos de regresión indican que el índice de accesibilidad, el balance entre empleos y viviendas, el valor del suelo y las variables aproximadas de uso del suelo (proporción de trabajadores en el sector secundario y terciario muestran efectos estadísticamente significativos al explicar diferencias en los tiempos de traslado al trabajo en transporte público. Así mismo, el índice de accesibilidad, valor del suelo y la proporción de trabajadores en el sector secundario incrementan dichos tiempos en transporte privado. Los resultados tienen implicaciones en términos de políticas de usos del suelo y planeación del transporte.

  9. Mujeres indígenas, gobierno y comunidad: El caso de mujeres tarahumaras en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Martha Estela Pérez García

    2016-01-01

    Full Text Available La situación de las mujeres indígenas en Chihuahua se caracteriza por la marginación, pobreza y desigualdad. Por esta razón, algunos(as miembros de la etnia rarámuri obligados por las necesidades más elementales, emigran con sus familias a las principales ciudades de la entidad. En el caso específico de la comunidad indígena asentada en Ciudad Juárez, Chihuahua, encontramos que son mujeres quienes dirigen las tareas de gobierno, rol tradicionalmente asignados a los hombres. El objetivo de este artículo es realizar un acercamiento de la participación femenina en el gobierno de la colonia tarahumara, con el propósito de conocer cómo se genera esta participación, sus liderazgos y las formas de resolución de sus problemas al interior de la comunidad. Para este propósito se realizaron entrevista con representantes de la comunidad y sus dos gobernadoras, además de un grupo focal con la presidenta y un grupo de mujeres. Los resultados de esta investigación mostraron dos cuestiones significativas: la situación de extrema vulnerabilidad en que viven las indígenas en el entorno urbano y que el gobierno femenino usa estrategias apegadas al rol de género para mantener el orden, el liderazgo y mejorar la calidad de vida de su comunidad.

  10. Optical properties of (162173) 1999 JU3: in preparation for the JAXA Hayabusa 2 sample return mission

    Energy Technology Data Exchange (ETDEWEB)

    Ishiguro, Masateru [Department of Physics and Astronomy, Seoul National University, Gwanak, Seoul 151-742 (Korea, Republic of); Kuroda, Daisuke [Okayama Astrophysical Observatory, National Astronomical Observatory of Japan, Asakuchi, Okayama 719-0232 (Japan); Hasegawa, Sunao; Abe, Masanao; Yoshikawa, Makoto [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Sagamihara, Kanagawa 252-5210 (Japan); Kim, Myung-Jin [Department of Astronomy, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Choi, Young-Jun [Korea Astronomy and Space Science Institute, 776 Daedeokdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Moskovitz, Nicholas [Lowell Observatory, 1400 W. Mars Hill Road, Flagstaff, AZ 86001 (United States); Abe, Shinsuke [Department of Aerospace Engineering, Nihon University, 7-24-1 Narashinodai Funabashi, Chiba 274-8501 (Japan); Pan, Kang-Sian [Institute of Astronomy, National Central University, 300 Jhongda Road, Jhongli, Taoyuan 32001, Taiwan (China); Takahashi, Jun; Takagi, Yuhei; Arai, Akira [Nishi-Harima Astronomical Observatory, Center for Astronomy, University of Hyogo, Sayo, Hyogo 679-5313 (Japan); Tokimasa, Noritaka [Sayo Town Office, 2611-1 Sayo, Sayo-cho, Sayo, Hyogo 679-5380 (Japan); Hsieh, Henry H. [Academia Sinica Institute of Astronomy and Astrophysics, Roosevelt Road, Taipei 10617, Taiwan (China); Thomas-Osip, Joanna E.; Osip, David J. [The Observatories of the Carnegie Institute of Washington, Las Campanas Observatory, Colina El Pino, Casilla 601, La Serena (Chile); Urakawa, Seitaro [Bisei Spaceguard Center, Japan Spaceguard Association, 1716-3 Okura, Bisei-cho, Ibara, Okayama 714-1411 (Japan); Hanayama, Hidekazu [Ishigakijima Astronomical Observatory, National Astronomical Observatory of Japan, 1024-1 Arakawa, Ishigaki, Okinawa 907-0024 (Japan); Sekiguchi, Tomohiko [Department of Teacher Training, Hokkaido University of Education, 9 Hokumon, Asahikawa 070-8621 (Japan); and others

    2014-09-01

    We investigated the magnitude-phase relation of (162173) 1999 JU3, a target asteroid for the JAXA Hayabusa 2 sample return mission. We initially employed the International Astronomical Union's H-G formalism but found that it fits less well using a single set of parameters. To improve the inadequate fit, we employed two photometric functions: the Shevchenko and Hapke functions. With the Shevchenko function, we found that the magnitude-phase relation exhibits linear behavior in a wide phase angle range (α = 5°-75°) and shows weak nonlinear opposition brightening at α < 5°, providing a more reliable absolute magnitude of H {sub V} = 19.25 ± 0.03. The phase slope (0.039 ± 0.001 mag deg{sup –1}) and opposition effect amplitude (parameterized by the ratio of intensity at α = 0.°3 to that at α = 5°, I(0.°3)/I(5°) = 1.31 ± 0.05) are consistent with those of typical C-type asteroids. We also attempted to determine the parameters for the Hapke model, which are applicable for constructing the surface reflectance map with the Hayabusa 2 onboard cameras. Although we could not constrain the full set of Hapke parameters, we obtained possible values, w = 0.041, g = –0.38, B {sub 0} = 1.43, and h = 0.050, assuming a surface roughness parameter θ-bar = 20°. By combining our photometric study with a thermal model of the asteroid, we obtained a geometric albedo of p {sub v} = 0.047 ± 0.003, phase integral q = 0.32 ± 0.03, and Bond albedo A {sub B} = 0.014 ± 0.002, which are commensurate with the values for common C-type asteroids.

  11. Optical properties of (162173) 1999 JU3: in preparation for the JAXA Hayabusa 2 sample return mission

    International Nuclear Information System (INIS)

    Ishiguro, Masateru; Kuroda, Daisuke; Hasegawa, Sunao; Abe, Masanao; Yoshikawa, Makoto; Kim, Myung-Jin; Choi, Young-Jun; Moskovitz, Nicholas; Abe, Shinsuke; Pan, Kang-Sian; Takahashi, Jun; Takagi, Yuhei; Arai, Akira; Tokimasa, Noritaka; Hsieh, Henry H.; Thomas-Osip, Joanna E.; Osip, David J.; Urakawa, Seitaro; Hanayama, Hidekazu; Sekiguchi, Tomohiko

    2014-01-01

    We investigated the magnitude-phase relation of (162173) 1999 JU3, a target asteroid for the JAXA Hayabusa 2 sample return mission. We initially employed the International Astronomical Union's H-G formalism but found that it fits less well using a single set of parameters. To improve the inadequate fit, we employed two photometric functions: the Shevchenko and Hapke functions. With the Shevchenko function, we found that the magnitude-phase relation exhibits linear behavior in a wide phase angle range (α = 5°-75°) and shows weak nonlinear opposition brightening at α < 5°, providing a more reliable absolute magnitude of H V = 19.25 ± 0.03. The phase slope (0.039 ± 0.001 mag deg –1 ) and opposition effect amplitude (parameterized by the ratio of intensity at α = 0.°3 to that at α = 5°, I(0.°3)/I(5°) = 1.31 ± 0.05) are consistent with those of typical C-type asteroids. We also attempted to determine the parameters for the Hapke model, which are applicable for constructing the surface reflectance map with the Hayabusa 2 onboard cameras. Although we could not constrain the full set of Hapke parameters, we obtained possible values, w = 0.041, g = –0.38, B 0 = 1.43, and h = 0.050, assuming a surface roughness parameter θ-bar = 20°. By combining our photometric study with a thermal model of the asteroid, we obtained a geometric albedo of p v = 0.047 ± 0.003, phase integral q = 0.32 ± 0.03, and Bond albedo A B = 0.014 ± 0.002, which are commensurate with the values for common C-type asteroids.

  12. [A case of advanced gastric cancer with carcinomatosa peritonitis effectively treated by 5-FU and low-dose CDDP therapy].

    Science.gov (United States)

    Saito, E; Kunii, Y; Wada, G; Tsuchiya, S; Yamasaki, T; Sakakibara, N

    1997-07-01

    A 66-year-old woman was admitted to our clinic for appetite loss and abdominal distension in August 1995. Endoscopic study revealed an advanced gastric cancer in the upper body of her stomach. Abdominal CT study revealed massive ascites and para-aortic lymph nodal involvement. Cytological study of the ascites revealed class V. She was diagnosed to be in the terminal stage of gastric cancer with carcinomatosa peritonitis. Combination chemotherapy with 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) was given by continuous intravenous injection of 5-FU 500 mg/day, and intermittent intravenous injection of CDDP 30 mg/week was performed for reduction of the ascites and her complaint. Endoscopic study 6 weeks after starting chemotherapy could not find crater of the gastric cancer but only a shallow ulcerative lesion. The biopsy specimen of that lesion was group III. No ascites and over 50% reduction of the para-aortic lymph node were found by the abdominal CT study. This state persisted over 4 weeks. No myelo-suppression, renal dysfunction or any severe side effect were observed during chemotherapy. Her performance status improved from 3 to 1.

  13. Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC-MS based metabolomics.

    Science.gov (United States)

    Xu, Jie; Hu, Feng-Lin; Wang, Wei; Wan, Xiao-Chun; Bao, Guan-Hu

    2015-11-01

    Fu brick tea (FBT) is a unique post-fermented tea product which is fermented with fungi during the manufacturing process. In this study, we investigated the biochemical compositional changes occurring during the microbial fermentation process (MFP) of FBT based on non-targeted LC-MS, which was a comprehensive and unbiased methodology. Our data analysis took a two-phase approach: (1) comparison of FBT with other tea products using PCA analysis to exhibit the characteristic effect of MFP on the formation of Fu brick tea and (2) comparison of tea samples throughout the MFP of FBT to elucidate the possible key metabolic pathways produced by the fungi. Non-targeted LC-MS analysis clearly distinguished FBT with other tea samples and highlighted some interesting metabolic pathways during the MFP including B ring fission catechin. Our study demonstrated that those fungi had a significant influence on the biochemical profiles in the FBT and consequently contributed to its unique quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Quaternary alluvial fans of Ciudad Juárez, Chihuahua, northern México: OSL ages and implications for climatic history of the region

    Science.gov (United States)

    Zúñiga de León, David; Kershaw, Stephen; Mahan, Shannon

    2016-01-01

    Alluvial fans formed from sediments derived from erosion of the Juárez Mountains in northernmost México have a significant flood impact on the Ciudad Juárez, which is built on the fan system. The northern part of Ciudad Juárez is the most active; further south, older parts of the fan, upon which the rest of the city is built, were largely eroded by natural processes prior to human habitation and subsequently modified only recently by human construction. Three aeolian sand samples, collected from the uppermost (youngest) parts of the fan system in the city area, in places where human intervention has not disturbed the sediment, and constrain the latest dates of fan building. Depositional ages of the Quaternary alluvial fans were measured using Optically Stimulated Luminescence (OSL) on aeolian sands that have inter-fingered with alluvial fan material. These dates are: a) sample P1, 31 ka; b) sample P2, 41 ka; c) sample P3, 74 ka, between Oxygen Isotope Stages (OIS) 3 to 5. They demonstrate that fan development, in the area now occupied by the city, terminated in the Late Pleistocene, immediately after what we interpret to have been an extended period of erosion without further deposition, lasting from the Late Pleistocene to Holocene. The three dates broadly correspond to global glacial periods, implying that the cool, dry periods may reflect periods of aeolian transport in northern México in between phases that were wetter to form the alluvial fans. Alluvial fan margins inter-finger with fluvial terrace sediments derived from the Río Bravo, indicating an additional component of fan dissection by Río Bravo lateral erosion, presumed to be active during earlier times than our OSL ages, but these are not yet dated. Further dating is required to ascertain the controls on the fan and fluvial system.

  15. La vegetación como sistema de control para las Islas de Calor Urbano en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Maria Goretti Salas Esparza

    2017-06-01

    Full Text Available A nivel mundial, el territorio ha experimentado un proceso de urbanización, el cual ha modificado las condiciones físicas y climatológicas como consecuencia de la densificación y construcción de las zonas urbanas, sobre todo a partir de la utilización de materiales que retienen el calor y que propician el fenómeno de isla de calor urbano (ICU, término establecido por Gordon Manley en 1958 (Fernández, 1996. Este trabajo evalúa el impacto que tienen las áreas verdes para actuar como sistema de control de isla de calor sobre Ciudad Juárez, Chihuahua, durante el verano del 2016. La metodología consistió en analizar cuatro áreas verdes para determinar la diferencia de temperatura que existe entre las zonas arboladas y las no arboladas, registrando temperaturas con sensores Hobo®, cada 15 minutos. Los resultados obtenidos demostraron que existe una diferencia de temperatura de 3,82 °C entre los lugares arbolados y no arbolados en el área verde con mayor nivel de vegetación, mientras que el área verde con menor nivel de vegetación se encontró una diferencia de 0,53 °C. Sin embargo, el impacto que tendrán sobre la zona urbana dependerá de la configuración y características de la misma área verde.   Documeto fianciado bajo el marco Tesis de Maestría en Planificación y Desarrollo Urbano " Áreas verdes como sistema de control para las Islas de Calor Urbano en Ciudad Juárez, Chihuahua".Universidad Autónoma de Ciudad Juárez

  16. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Science.gov (United States)

    Wadley, Lyn; Trower, Gary; Backwell, Lucinda; d'Errico, Francesco

    2015-01-01

    Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone Age sites of Diepkloof

  17. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Directory of Open Access Journals (Sweden)

    Lyn Wadley

    Full Text Available Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone

  18. [Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].

    Science.gov (United States)

    Li, Dayu; Liu, Yun; Yu, Chunbo; Liu, Xiping; Fan, Fang

    2017-12-01

    Objective To study the effect of the knock-down of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on the cell cycle of the multidrug-resistant (MDR) Bel7402/5-Fu hepatocellular carcinoma cells and its MDR mechanism. Methods After cationic liposome-mediated siDNA-PKcs oligonucleotide transfection, the drug sensitivity of Bel7402/5-Fu cells to 5-fluorouracil (5-Fu) and adriamycin (ADM) was determined by MTT assay; the cell cycle were detected by flow cytometry; meanwhile, the protein expressions of cell cycle-related proteins P21, cell cycle protein B1 (cyclin B1), cell cycle division protein 2 (CDC2) were tested by Western blotting; the expressions of ataxia telangiectasia mutated (ATM) and p53 at both mRNA and protein levels were detected by real-time PCR and Western blot analysis. Results The MTT results showed siDNA-PKcs increased the chemotherapeutic sensitivity of Bel7402/5-Fu cells to 5-Fu and ADM. The flow cytometric analysis showed siDNA-PKcs decreased the percentage of S-phase cells but increased the percentage of G2/M phase cells. Western blotting showed siDNA-PKcs increased the protein expression of P21 but decreased cyclinB1 and CDC2 proteins. In addition, siDNA-PKcs also increased the expressions of ATM and p53. Conclusion DNA-PKcs silencing increases P21 while decreases cyclin B1 and CDC2 expressions, and finally induces G2/M phase arrest in Bel7402/5-Fu cells, which may be related to ATM-p53 signaling pathway.

  19. Zavzetost zaposlenih na področju Dolenjske : diplomsko delo visokošolskega študija Varnost in policijsko delo

    OpenAIRE

    Kovšca, Anja

    2014-01-01

    Povzetek– Zavzetost zaposlenih na področju Dolenjske Zavzetost zaposlenih pomeni združitev predanosti, pripadnosti in produktivnosti, ki je hkrati tudi pomemben element konkurenčnosti. V teoretičnem delu naloge je pojasnjena zavzetost zaposlenih, ki se dotakne tudi zadovoljstva zaposlenih. Razčlenjeni so tudi stopnja in dejavnike zavzetosti zaposlenih. Zaključimo z vlogo vodij pri doseganju zavzetosti zaposlenih. V empiričnem delu preverimo začetna raziskovalna vprašanja, ki so zasnovana...

  20. O juízo dos súditos na república Hobbesiana = The subjects’ discretion in the Hobbesian commonwealth

    Directory of Open Access Journals (Sweden)

    Villanova, Marcelo Gross

    2011-01-01

    Full Text Available A discrição da presença do princípio de reciprocidade na formulação hobbesiana oblitera importantes dimensões na sua teoria. Entre estas, a necessidade intrínseca de que os súditos estejam instados a utilizar a sua capacidade de produzir juízos. Apresentam-se diversas circunstâncias que corroboram essa tese, o que mostra que a atividade de julgar não foi confiscada pelo soberano. Ao contrário, ela é mesmo necessária para o seu sistema

  1. “Manda quem pode, obedece quem tem juízo”: ou sobre a (desobediência e a razão em Hobbes

    Directory of Open Access Journals (Sweden)

    Rita Helena Sousa Ferreira Gomes

    2011-11-01

    Full Text Available Partindo do dito popular “manda quem pode, obedece quem tem juízo” o presente artigo tem como objetivo defender a tese de que o Estado hobbesiano sustenta-se tanto pela força quanto pela razáo. Dentro desta perspectiva, será analisada a noçáo de desobediência e, ao final, mostrar-se-á que o adágio referido só pode ser tido como verdadeiro de acordo com a filosofia política de Thomas Hobbes após feitas certas ressalvas.

  2. Maquiladoras de arneses automotrices: entre la producción de clase mundial y la precariedad laboral en Juárez

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Miker Palafox

    2010-11-01

    Full Text Available This article show how the globalization process has impacted in the harness maquiladora industry in Ciudad Juárez and how job insecurity and world-class production can coexist in the production of automotive harness where two of the main local stakeholders (unions and the State are completely blurred and accomplices. The document is based mainly in the analysis of four cases of maquiladora plants producing automotive harnesses owned by world leading corporations, which concentrate over 90% of employment and harness production plants in the in the city.

  3. MASCOT, the small mobile package on its piggyback journey to 1999JU3: pre-launch and post-launch activities

    OpenAIRE

    Ziach, C.; Baturkin, V.; Ho, T. M.; Grimm, Ch.; Grundmann, J. T.; Lange, C.; Termantanasombat, N.; Weimo, E.; Findlay, R.; Reiil, J.; Lange, M.; Mierheim, O.; Biele, J.; Krause, C.; Ulamec, S.

    2015-01-01

    Since December 2014 the Japanese spacecraft Hayabusa2 is on its journey to asteroid (162173) 1999 JU3. Like its famous predecessor it is expected to study and return samples from its target body. This time, the mother spacecraft has several small passengers. One of them is a compact landing package called MASCOT (Mobile Asteroid surface SCOuT), which has been developed by the German Aerospace Centre (DLR) and the Centre National d'Etudes Spatiales (CNES). Once having been released from its mo...

  4. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico.

    Science.gov (United States)

    Bird, Yelena; Staines-Orozco, Hugo

    2016-01-01

    Youth smoking trends among Latin American countries, including Mexico, are on the rise. Notably, although the high prevalence of smoking in teens has been well documented in the literature, few studies have evaluated the impact of smoking and secondhand smoke (SHS) exposure on their respiratory system. To investigate the effects of smoking and SHS exposure on the respiratory health and lung function among eighth-grade students in Juárez, Mexico. A cross-sectional study was undertaken on a sample of convenience. The study outcomes centered on evaluating 300 students' lung function by spirometry (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC], and forced mid-expiratory flow rate [FEF25%-75%]) and their respiratory health (smoking behavior and SHS exposure) by their self-reported responses to a standardized respiratory questionnaire. The study outcomes were compared among three distinct groups: 1) nonsmokers/nonexposed to SHS; 2) nonsmokers/exposed to SHS; and 3) smokers. The majority of the study participants were 14 years old (85%), females (54%), who attended eighth grade in a public school setting (56%). Approximately, half reported being of low socioeconomic status (49%) and nonsmokers/exposed to SHS (49%). The lung function parameters of smokers were found to be lower (FEV1 =62.88±10.25; FEV1/FVC =83.50±14.15; and FEF25%-75% =66.35±12.55) than those recorded for the nonsmokers/exposed to SHS (FEV1 =69.41±11.35; FEV1/FVC =88.75±15.75; and FEF25%-75% =78.90±14.65) and significantly reduced when compared to the nonsmokers/nonexposed to SHS (FEV1 =79.14±13.61; FEV1/FVC =94.88±21.88; and FEF25%-75% =87.36±17.02) (P<0.001). Similarly, respiratory complaints were more prevalent among smokers and those exposed to SHS when compared to nonsmokers/nonexposed to SHS. Our findings suggest that initiation of cigarette smoking and, to a lesser extent, exposure to SHS in adolescence leads to

  5. ANCEI--Ju-ne

    Indian Academy of Sciences (India)

    which are in the vicinity of the solar system, say within a distance of about 150 lightyears from us. Beyond this distance it is ... stellar systems, or the universe. In fact, it was not known then that we live in a galaxy called .... and determine its distance as accurately as pos- sible. Henrietta Leavitt made the prime discovery of her.

  6. I -JU-Iy

    Indian Academy of Sciences (India)

    agents should not simply act in response to their environment, they should be able ..... and even finalize business transactions on behalf of their own- ers. ... Refresher Course on coding theory, cryptography and discrete mathematics. About 30 ...

  7. JU-ly

    Indian Academy of Sciences (India)

    present a personal account of what I experienced in the years (1920s to the 1950s) that were so ... my education in Germany, where evolution was not really controversial. In the gymna- ... ered valid in England or in France were rejected in Germany or the United States. One powerful .... The two belief systems had only one ...

  8. nancei--ju-iy

    Indian Academy of Sciences (India)

    22 Breeding Ecology of Birds. Why do Some Species Nest Singly While Others are Colonial? Abdul Jomil Urfi. 33 Noise Assisted Direded Motion at the. Molecular Level - 1. Mongol C Mohoto and A M Joyonnavar. 46 Chelates for Micronutrient Nutrition among Crops. B 5 Sekhon. Amplitude/frequency modulated.

  9. JU-IY

    Indian Academy of Sciences (India)

    The appearance of an Indian edition of Bela Bollobas' book 'Linear Analysis' must surely be welcomed by advanced undergraduate and masters level students in this country. The author mentions that the book reflects the way he would have liked to have been taught analysis. Many readers will, undoubtedly, echo the ...

  10. ju-iy

    Indian Academy of Sciences (India)

    longest single-ring parent (288 carbons), the ... realise the impact of the project not only in ... in style that would appeal to a large readership. ... Betty realises that three of her six children ... however self-centred the punchline could be ... The existence of a slightly different but ... the confidence of the people helped the.

  11. JU-ne

    Indian Academy of Sciences (India)

    Consider the case of air gushing out of a small opening in a canister containing pressurized air, with pressure Po; then. We intuitively know that a 'thrust' is produced in a direction opposite to the jet of air issuing out. Let -F be the force acting on the support; the support will exert an equal and opposite F force on the canister.

  12. ancei--ju-iy

    Indian Academy of Sciences (India)

    Later, John Wheeler and Bohr ex- ... probability that two particles with similar sign get very close is zero. Gamow realised that quantum tunneling can make this probability non-zero (al- ... league Robert Herman, he was the first to develop.

  13. NANCEI--Ju-ne

    Indian Academy of Sciences (India)

    In this context it is difficult to avoid the temptation to recall a few other memorable ... thing else for that matter, was far from his mind, Lorenz and his ... ertoire of all the things a duck can say or do", ... Lorenz was a personality hard to ignore. His.

  14. Ju-ne

    Indian Academy of Sciences (India)

    year the figure may rise to 85 or more. Each country ... final paper, consisting of 6 problems, is prepared from the shortlist by the team leaders, who ... Wien saw no reason to pass the young man, no matter how brilliant he was in other fields.

  15. ju-iy

    Indian Academy of Sciences (India)

    . Back Cover .,i ... (Courtesy: NASAl. Ernst Walter Mayr. (1904-2005). (Illustration : Subhankar Biswasl. [!l!;7a ... ~. Editorial. 01. Editor's Column. SMahadevan. Article-in-a-Box. Ernst Walter Mayr -. 02. The Grand Vizier of. Evolutionary Biology.

  16. i--ju-iy

    Indian Academy of Sciences (India)

    education and obtained his basic science degree in 1931. ... In 1941, in the middle of the war, he got his doctorate degree. .... operon model that all high school biology stu- dents learn ... protein in hand, the operator DNA it binds with could be ...

  17. Comercio transfronterizo y su impacto en la región de El Paso-Ciudad Juárez: Una propuesta de financiamiento de la planeación binacional

    Directory of Open Access Journals (Sweden)

    Sergio Peña

    2003-01-01

    Full Text Available El presente artículo analiza el impacto del comercio transfronterizo en la región de El Paso-Ciudad Juárez, entendido como tal el valor de las compras que los consumidores mexicanos realizan en El Paso. Los resultados muestran que el monto de las ventas al menudeo en esta ciudad en el año 2000 excedieron en 33% los valores ajustados del modelo. Este último debe interpretarse como el efecto del comercio transfronterizo. Los impuestos generados por el comercio transfronterizo suman aproximadamente 125 millones de dólares y equivalen aproximadamente a los egresos brutos totales del municipio de Ciudad Juárez en el año 2000. El artículo pone de relieve la potencialidad que tendrían esos recursos para el financiamiento del desarrollo urbano binacional de El Paso y Ciudad Juárez

  18. Desenvolvimento de um Iogurte Sabor Juçaí (Euterpe edulis Martius: Avaliação Físico-química e Sensorial

    Directory of Open Access Journals (Sweden)

    Gislaine Natiele dos Santos Costa

    2015-07-01

    Full Text Available A busca constante por melhorias na qualidade de vida, saúde e bemestar dos consumidores tem levado ao desenvolvimento de novos produtos. Devido a esta influência o leite e seus derivados considerados como alimentos funcionais vêm apresentando um aumento significativo no consumo. Este trabalho apresenta o processo de desenvolvimento de um iogurte sabor juçaí, fruto da palmeira juçara (Euterpe edulis Martius. Rico em nutrientes como ferro e potássio. Este fruto é similar ao açaí fruto da palmeira Euterpe oleracea Martius, porém apresenta, segundo a literatura, maior teor de antocianinas. As antocianinas possuem alto poder antioxidante e inibem a ação de radicais livres nas células diminuindo seus efeitos ao organismo humano. No desenvolvimento do produto foram preparadas formulações contendo, respectivamente, 3%, 5% e 7% da polpa da fruta visando adquirir além de funcionalidade, melhor consistência e sabor para o produto. A aceitabilidade do produto foi avaliada por meio de análise sensorial.

  19. Application of foam column as green technology for concentration of saponins from sisal (Agave sisalana and Juá (Ziziphus joazeiro

    Directory of Open Access Journals (Sweden)

    B. D. Ribeiro

    2013-12-01

    Full Text Available Saponins, molecules classified as triterpenic or steroidal glycosides, are metabolites distributed in all the plant kingdom that can be used for the production of foods, cosmetics, and pharmaceuticals, as well as in soil bioremediation. Saponins are normally extracted from natural resources with water, ethanol and/or methanol, and then concentrated by liquid-liquid partitioning with n-butanol. An alternative concentration method is with a foam column, by which the saponins can be concentrated via preferential adsorption at a gas-liquid interface. Therefore, the objective of this work was the use of a foam column for the concentration of saponins from juá and sisal, evaluating parameters such as: initial working volume in the column, saponin concentration in the extracts from juá and sisal, air flow rate, pH, Raschig rings loading and operation time. When a gradient air flow rate and 25 g of Raschig rings were used, 82.6% of the jua saponins loaded onto the system were recovered in a 3.46-fold concentrated solution after 9 h of operation. Regarding sisal saponins, a concentration factor of 1.98 was observed with 90.5% of saponin recovery during 4.5 h of operation.

  20. Coletivos de trabalho, inserção e formação: o caso dos juízes do trabalho

    Directory of Open Access Journals (Sweden)

    Genilza Evaristo Machado

    Full Text Available O artigo propõe-se a refletir sobre os processos de inserção profissional e formação continuada de juízes do trabalho de um Tribunal localizado na Região Norte do Brasil, colocando em destaque, a partir da contribuição de algumas abordagens clínicas do trabalho, a função que os coletivos de trabalho podem desempenhar nesses processos. O artigo baseia-se em pesquisa qualitativa, da qual participaram treze juízes, por meio de entrevistas individuais semiestruturadas, examinadas pela técnica da análise de conteúdo temática. Os resultados evidenciam que a inserção na magistratura é marcada por dúvidas, receios, medos e inseguranças, e que sua formação continuada se vê prejudicada pelo aumento do volume de tarefas que consomem a jornada de trabalho, avançando em uma faixa do tempo extratrabalho. Tais dificuldades são enfrentadas na solidão ou, quando muito, com o apoio de um círculo muito restrito de pares. Sugere-se que as dificuldades seriam mais bem geridas caso os coletivos de trabalho se mostrassem mais receptivos.

  1. Vadītāju vadības lomu novērtējums uzņēmumā SIA "DKD".

    OpenAIRE

    Tomiņš, Dāvis

    2016-01-01

    Bakalaura darba tēma ir “Vadītāju vadības lomu novērtējums uzņēmumā SIA DKD”. Bakalaura darba mērķis ir, pamatojoties uz pieejamo informāciju, par vadības lomām un pētījumā iegūto datu analīzi, pilnveidot vadītāja vadīšanas pieejas organizācijā, identificējot nepilnības vadītāju lomu izmantošanā. Darba mērķa sasniegšanai autors izvirzīja sekojošus uzdevumus - iepazīties un izpētīt zinātnisko literatūru par vadītāja vadības lomām, izpētīt uzņēmuma sabiedrība ar ierobežotu atbildību “DKD” vadīb...

  2. Los cambios en la estructura intraurbana de Ciudad Juárez, Chihuahua, de monocéntrica a multicéntrica

    Directory of Open Access Journals (Sweden)

    César M. Flores Fuentes

    2001-01-01

    Full Text Available El artículo tiene como objetivo analizar los cambios en la estructura intraurbana de Ciudad Juárez, Chihuahua, durante el periodo 1989-1993. Para ello se usaron los censos económicos de comercio y servicios de 1989 y 1994, el censo de población de 1990 y el conteo de población de1995, ambos a nivel de AGEB. Lo anterior fue posible mediante la construcción del índice de centralidad. En 1989 la estructura intraurbana de Ciudad Juárez mostró la presencia de dos centros principales. Dichos centros, aunque con la misma jerarquía urbana, tienen distintas funciones, como resultado de contar con ramas económicas que tienen diferentes áreas de mercado, desigual densidad poblacional y distinta capacidad de compra de sus principales consumidores. Para 1994 la ciudad siguió teniendo esos dos centros principales, aunque se crearon tres nuevos subcentros que se localizan fuera de las tradicionales áreas centrales, en zonas de fácil acceso y buena infraestructura. En este contexto, la estructura intraurbana se encuentra en proceso de convertirse de monocéntrica en multicéntrica

  3. Política social, protección social y programa empleo temporal: el caso Juárez, México

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Roqueme Ramírez

    2013-01-01

    Full Text Available Este trabajo es un análisis del Programa Empleo Temporal (PET en Ciudad Juárez en el marco del concepto protección social. Para ello se indaga acerca de la política social en México como un intento de comprender hasta qué punto ha contribuido dicho programa a esta alternativa de desarrollo. En este sentido, la revisión bibliográfica se empleó como una herramienta documental y metodológica que permitió conocer otras experiencias en América Latina para situar que la problemática del desempleo y la protección constituyen aún un desafío. Ciudad Juárez no es la excepción. La indagación del PET conduce a proponer que, aunque sus efectos sean positivos temporalmente, los resultados obtenidos son limitados ya que las políticas de acción están encaminadas a solventar en su mayoría contingencias y no una sustentabilidad a mediano y largo plazo. Finalmente, se propone la creación de un índice para monitorear y evaluar el impacto del PET en términos de cobertura, del perfil de los beneficiarios y de los ingresos generados entre los beneficiados.

  4. Izpildes pamatrādītāju modelēšana un implementēšanas iespējas

    OpenAIRE

    Kalniņa, Anna

    2016-01-01

    Nozīmīga loma organizācijas darbības uzlabošanā un novērtēšanā ieņem izpildes pamatrādītāji. Tie palīdz novērtēt organizācijas darbību mērot nodefinētos mērķus tādā veidā nosakot vai nodefinētie mērķi tiek sasniegti. Lai novērtētu organizācijas darbību, nepieciešams izveidot indikatoru modeli. Maģistra darbā “Izpildes pamatrādītāju modelēšana un implementēšanas iespējas” apskatītas literatūrā pieejamās izpildes pamatrādītāju modeļa izveidošanas metodes un izveidots indikatoru modelis izmantoj...

  5. Convergencia tecnológica y nacimiento de las maquiladoras de tercera generación: el caso Delphi-Juárez

    Directory of Open Access Journals (Sweden)

    Arturo Lara Rivero

    2001-01-01

    Full Text Available El objetivo de este trabajo es el de explicar el nacimiento de un moderno, inédito centro de investigación y desarrollo de auto partes electrónicas: Delphi - Juárez . La pregunta básica que guía este trabajo es la siguiente: ¿cuáles son las implicaciones de la convergencia tecnológica electrónica / automotriz sobre el número, distribución espacial y jerárquica de los proveedores? Esta convergencia tecnológica viene a revalorizar las antiguas funciones eléctricas (y tanto a los viejos proveedores de partes eléctricas maduras como a los proveedores de arneses y a insertarlas en una nueva jerarquía tecnológica con interacciones más intensas entre proveedores de arneses, léase maquiladoras del sector auto partes electrónicos / eléctricos y las empresas propiamente automotrices. Resulta imprescindible leer la formación del centro de investigación y desarrollo Delphi Juárez desde la perspectiva de los procesos de convergencia, resolución de desequilibrios tecnológicos y coevolución tecnológica del campo electrónico y automotriz.

  6. Globalizācijas procesu ietekme uz sociālā tīkla facebook.com lietotāju motivāciju

    OpenAIRE

    Krastiņa, Elīna

    2010-01-01

    Bakalaura darba tēma ir „Globalizācijas ietekme uz sociālā tīkla facebook.com lietotāju motivāciju”. Tā mērķis ir aplūkot globālo sociālo tīklu facebook.com kā globalizācijas izpausmju piemēru un izpētīt tā lietotāju motivāciju - vai un cik lielā mērā to ietekmē globalizācijas procesi un to izraisītās blakusparādības. Darba ietvaros apskatītas vairākas pieejas globalizācijas jēdziena skaidrojumam, kā arī apskatītas globalizācijas ietekmes un sekas – kultūras globalizācija, kosmopolītisms u. c...

  7. Influence of JuA in evoking communication changes between the small intestines and brain tissues of rats and the GABAA and GABAB receptor transcription levels of hippocampal neurons.

    Science.gov (United States)

    Wang, Xi-Xi; Ma, Gu-Ijie; Xie, Jun-Bo; Pang, Guang-Chang

    2015-01-15

    Jujuboside A (JuA) is a main active ingredient of semen ziziphi spinosae, which can significantly reduce spontaneous activity in mammals, increase the speed of falling asleep, prolong the sleeping time as well as improve the sleeping efficiency. In this study, the mechanism and the pathway of the sedative and hypnotic effect of JuA were investigated. After being treated with JuA (in vitro), the rat׳s small intestine tissues cultures were used to stimulate the brain tissues. Then 27 cytokine levels were detected in the two kinds of tissue culture via liquid protein chip technology; In addition, the cultured hippocampal neurons of rat were treated with JuA, and γ-aminobutyric acid (GABA) receptor subunits (GABAAα1, GABAAα5, GABAAβ1 and GABABR1) mRNAs were evaluated by Real-time PCR. The levels of IL-1α, MIP-1α, IL-1β and IL-2 were reduced significantly after 3h of treating the small intestine tissues with JuA (200µl/ml), and the concentration change rates, in order, were -59.3%, -3.59%, -50.1% and -49.4%; these cytokines were transmitted to brain tissues 2h later, which could lead to significant levels of reduction of IL-1α, IFN-γ, IP-10 and TNF-α; the concentration change rates were -62.4%, -25.7%, -55.2% and -38.5%, respectively. Further, the intercellular communication network diagram was mapped out, which could suggest the mechanism and the pathway of the sedative and hypnotic effect of JuA. The results also indicated that JuA (50µl/ml) increased significantly GABAAα1 receptor mRNAs and reduced GABABR1, mRNAs in hippocampal neurons after 24h of stimulation; however, all the mRNA transcription levels of GABAAα1,GABAAα5, GABAAβ1 and GABABR1 receptors increased significantly after 48h. JuA performed its specific sedative and hypnotic effect through not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine

  8. Non-viral genetic transfection of rat Schwann cells with FuGENE HD© lipofection and AMAXA© nucleofection is feasible but impairs cell viability.

    Science.gov (United States)

    Kraus, Armin; Täger, Joachim; Kohler, Konrad; Haerle, Max; Werdin, Frank; Schaller, Hans-Eberhard; Sinis, Nektarios

    2010-11-01

    To determine transfection efficiency of FuGENE HD© lipofection and AMAXA© nucleofection on rat Schwann cells (SC). The ischiadic and median nerves of 6-8 week old Lewis rats were cultured in modified melanocyte-growth medium. SCs were genetically transfected with green fluorescent protein (GFP) as reporter gene using FuGENE HD© lipofection and AMAXA© nucleofection. Transfection rates were determined by visualization of GFP fluorescence under fluorescence microscopy and cell counting. Transfected cell to non-transfected cell relation was determined. Purity of Schwann cell culture was 88% as determined by immunohistologic staining. Transfection rate of FuGENE HD© lipofection was 2%, transfection rate of AMAXA© nucleofection was 10%. With both methods, Schwann cells showed pronounced aggregation behavior which made them unfeasible for further cultivation. Settling of Schwann cells on laminin and poly-L-ornithine coated plates was compromised by either method. Non-viral transfection of rat SC with FuGENE HD© lipofection and AMAXA© nucleofection is basically possible with a higher transfection rate for nucleofection than for lipofection. As cell viability is compromised by either method however, viral transfection is to be considered if higher efficiency is required.

  9. Expression and Role of Oct3/4 in Injury-Repair Process of Rat Alveolar Epithelium after 5-Fu Treatment

    Directory of Open Access Journals (Sweden)

    Wen-ya Li

    2017-01-01

    Full Text Available Objective. We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu. Methods. We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. Immunofluorescence double staining was used to compare the positions of Oct3/4(+ cells and other reported alveolar epithelial stem cells. Results. Oct3/4(+ cells were not found in normal rat lung epithelial cells. However, after treatment with 5-Fu, Oct3/4(+ cells appeared at 12 h, reached the peak at 24 h, then decreased at 48 h, and eventually disappeared at 72 h. Oct3/4 was localized in the nucleus. We found that the sites of Clara cell secretory protein and surfactant protein-C dual positive cells were apparently different from Oct3/4(+ cells. Conclusions. Our results revealed that, in rat alveolar epithelium, expression of Oct3/4 could be induced after treatment with 5-Fu, then decreased gradually, and was silenced following the alveolar epithelial differentiation. We hold that Oct3/4(+ cells are lung stem cells, which can provide new evidence for identification and isolation of lung epithelial stem cells.

  10. [Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

    Science.gov (United States)

    Kimoto, M; Nagano, H; Sano, K

    1987-10-01

    The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

  11. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy.

    Science.gov (United States)

    Marks, Eric I; Tan, Carlyn; Zhang, Jun; Zhou, Lanlan; Yang, Zhaohai; Scicchitano, Angelique; El-Deiry, Wafik S

    2015-01-01

    We present 2 patients with metastatic colorectal cancer who had progressed despite treatment with first-line FOLFOX and second-line FOLFIRI combination chemotherapy regimens. After failing these fluoropyrimidine-based regimens, both patients received additional cytotoxic and targeted therapies with eventual disease progression. These therapies included capecitabine plus dabrafenib and trametinib, regorafenib monotherapy, and regorafenib with panitumumab. After exhausting available options, both patients were offered regorafenib with either 5-fluorouracil (5-FU) or capecitabine. These therapies are individually approved for the treatment of colorectal cancer but have not yet been studied in combination. This regimen produced stable disease in both patients with acceptable toxicity. One patient continued therapy for 17 months. Although these patients previously progressed during treatment with regorafenib, capecitabine or 5-FU, the combination had some activity in both cases of refractory metastatic colorectal cancer and may be considered in the palliative setting. In bedside-to-bench cell culture experiments performed after the clinical observations, we observed sensitivity of human colorectal cancer cell lines (N = 4) to single agent regorafenib or 5-FU and evidence of synergy with the combination therapy. Synergistic effects were noted in colorectal cancer cells with KRAS mutation, BRAF mutation, and p53 mutation, as well as mismatch repair deficient cells. Regorafenib suppressed Mcl-1 and Bcl-XL in treated cancer cells that may have contributed to the anticancer efficacy including in combination with 5-FU. The safety and efficacy of regorafenib with 5-FU or capecitabine in combination should be further investigated as a therapy for patients with refractory metastatic colorectal cancer, including individuals who had progressed on regorafenib monotherapy.

  12. Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

    Directory of Open Access Journals (Sweden)

    Ana de la Cueva

    Full Text Available Colorectal cancer (CRC is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα, an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in many different tumors, including colorectal tumors. ChoKα inhibitors have recently entered clinical trials as a novel antitumor strategy.ChoKα specific inhibitors, MN58b and TCD-717, have demonstrated a potent antitumoral activity both in vitro and in vivo against several tumor-derived cell line xenografts including CRC-derived cell lines. The effect of ChoKα inhibitors in combination with 5-FU as a new alternative for the treatment of colon tumors has been investigated both in vitro in CRC-tumour derived cell lines, and in vivo in mouse xenografts models. The effects on thymidilate synthase (TS and thymidine kinase (TK1 levels, two enzymes known to play an essential role in the mechanism of action of 5-FU, were analyzed by western blotting and quantitative PCR analysis. The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. ChoKα inhibitors modulate the expression levels of TS and TK1 through inhibition of E2F production, providing a rational for its mechanism of action.Our data suggest that both drugs in combination display a synergistic antitumoral effect due to ChoKα inhibitors-driven modulation of the metabolization of 5-FU. The clinical relevance of these findings is strongly supported since TCD-717 has recently entered Phase I clinical trials against solid tumors.

  13. In vitro propagation and analysis of secondary metabolites in Glossogyne tenuifolia (Hsiang-Ju) - a medicinal plant native to Taiwan.

    Science.gov (United States)

    Chen, Chia-Chen; Chang, Hung-Chi; Kuo, Chao-Lin; Agrawal, Dinesh Chandra; Wu, Chi-Rei; Tsay, Hsin-Sheng

    2014-12-01

    Glossogyne tenuifolia Cassini (Hsiang-Ju in Chinese) is a perennial herb native to Penghu Islands, Taiwan. The herb is a traditional anti-pyretic and hepatoprotective used in Chinese medicine. Several studies on G. tenuifolia have demonstrated its pharmacological values of antioxidation, anti-inflammation, immunomodulation, and cytotoxicity on several human cancer cell lines. Active compounds, oleanolic acid and luteolin in G. tenuifolia are affected by several factors, including climatic change, pathogens and agricultural practices. Plant population of G. tenuifolia has been severely affected and reduced considerably in natural habitat due to the use of herbicides by farmers. Also, collection of plant material from the natural habitat is restricted to a few months in a year. Therefore, the objective of the present study was to develop an efficient micropropagation protocol for G. tenuifolia. The study also aimed to investigate the influence of in vitro growth environment on the active compounds in in vitro shoots, tissue culture raised greenhouse plants; compare the values with wild plants and commercially available crude drug. Half-strength MS (Murashige and Skoog) basal medium supplemented with 0.1 mg/L 6-benzyladenine (BA) and 0.1 mg/L α-naphthaleneacetic acid (NAA) induced the maximum average number of shoots (7.3) per shoot tip explant excised from in vitro grown seedlings. Induction of rooting in cent percent in vitro shoots with an average number of 6.6 roots/shoot was achieved on ½ strength MS medium supplemented with 3.0 mg/L indole-3-acetic acid (IAA). The rooted plantlets acclimatized successfully in the greenhouse with a 100% survival rate. HPLC analysis revealed that the quantity of oleanolic acid and luteolin in in vitro shoots, tissue culture plants in the greenhouse, wild type plants and commercial crude drug varied depending upon the source. The oleanolic acid and luteolin contents were found to be significantly higher (16.89 mg/g and 0.84

  14. Juízo e ação moral: desafios teóricos em psicologia Judgment and moral action: theoretic challenges in psychology

    Directory of Open Access Journals (Sweden)

    Leonardo Lemos de Souza

    2009-12-01

    Full Text Available O presente artigo apresenta e discute a polêmica, no campo da psicologia moral, sobre as relações entre juízo e ação. Teorias de tradição racionalista e estruturalista, como as de Piaget e Kohlberg, afirmam uma relação de continuidade entre juízo e ação moral e, ao mesmo tempo, lançam pontos de discussão sobre a complexidade envolvida no tema. Por outro lado, novas frentes de trabalho sugerem a integração de outros elementos (a cultura, a afetividade e o self, além das estruturas que podem compor um referencial com o qual se evidenciem as relações entre os aspectos envolvidos nas condutas morais. Por fim, apesar das críticas acenarem com caminhos promissores na pesquisa sobre o juízo e a ação moral, ainda existem limites na construção de referenciais teóricos e metodológicos que articulem diferentes perspectivas de análise psicológica da moralidade.The attending article presents and discusses the debate within the cognitive constructivist theories, which have as main representatives Jean Piaget and Lawrence Kohlberg. Such theories of rationalist and structuralist tradition maintain continuity between judgment and moral action and, at the same time, launch points of discussion on the complexity involved in the theme. New work fronts suggest the integration of other elements: culture, affectionateness, and the self, beyond the structures that may compound a referential that explains the relations between the aspects involved in moral behavior. Lastly, despite the criticism indicating a promising path in the search about judgment and moral action, considering its complex character, there are still limits in the making of the theoretical and methodological frameworks that articulate different perspectives of moral psychological analyses.

  15. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  16. «A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939 / «A Ca’ Giustinian fu tutto diverso» (At Ca’ Giustiniani eveything was different. Paolo Veronese exhibition in Venice (1939

    Directory of Open Access Journals (Sweden)

    Matilde Cartolari

    2016-12-01

    Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

  17. Activismo transnacional y calidad de la democracia en México: Reflexiones en torno al caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Alberto Martín

    2008-04-01

    Full Text Available Abstract: Transnational activism and quality of democracy  in Mexico: reflections centring on the case of Ciudad JuárezThis article analyses the impact of transnational  activism in the call to solve the deaths of hundreds of women in Cuidad Juárez. The efforts of  organizations of relatives of disappeared women  to secure the solidarity of national and international organizations and networks have been crucial  in influencing the federal Mexican government to  investigate these crimes. In addition, by placing  the problem inside wider frames of interpretation  – those of gender violence and human rights–, the  organizations of Juarez have helped to open the  debate concerning the question of violence in  general against women in Mexico. Nevertheless,  the results of the movement at the local level are  still far from satisfactory due to questions related  both to internal problems and weaknesses of local  organizations as well as to structural problems of  democracy in Mexico, which include the weakness of rule of law and the ineffectiveness of the  political system in implementing effective accountability.Resumen:El artículo analiza el impacto de la internacionalización de la movilización en pro del esclarecimiento de los crímenes cometidos contra mujeres  en Ciudad Juárez, México. La capacidad de las  organizaciones de familiares de desaparecidas de  concitar la solidaridad de organizaciones y redes  nacionales e internacionales, ha sido determinante  para desencadenar la intervención del gobierno  federal mexicano en la investigación de los crí- menes. Asimismo, a través de la inserción del  problema en marcos de interpretación más amplios – los de la violencia de género y los derechos humanos -, las organizaciones de Juárez han  contribuido a abrir el debate en torno a la violencia contra la mujer en México. Sin embargo, a  nivel local los resultados del movimiento se encuentran aún lejos

  18. Between fear and differentiation. The current situation of gated communities within border towns such as Tijuana, Nogales and Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Jesús Ángel Enríquez Acosta

    2007-01-01

    Full Text Available In the cities of Tijuana, Nogales and Ciudad Juárez, located in the northwestern border between Mexico and the United States, one of the more popular urbanization processes is the modality of closed divisions. These residential areas are characterized for being a physical space protected and separated from the city disturbances with bars and fences, and most of them present monitoring houses with access restrictions and private surveillance. The concept of closed divisions tends to expand in the urban landscape of the border cities without restrictions except for those established by the real estate market. Nevertheless, it's important to analyze the impact of closed divisions in the morphology of the cities, the urban sustentability of this developments and the social segregation they cause.

  19. Condiciones de trabajo en la industria maquiladora de tipo electrónico. El caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Lilia Venegas Aguilera

    1985-01-01

    Full Text Available Este trabajo es un avance de la investigación emprendida en el año de 1981 realizada en torno a las condiciones de vida y de trabajo en la industria maquiladora. Para ello se eligió a Ciudad Juárez, que para 1982 contaba ya con 42,695 trabajadores en este tipo de industria. En primer lugar se presenta la importancia y características de esta industria, particularmente de tipo electrónico, y dentro de este marco referencial se aborda el análisis de las condiciones laborales de las trabajadoras de esta rama industrial que representaban el 67% del total de trabajadores de maquiladoras de esa ciudad fronteriza. La fuente de información proviene de una encuesta aplicada en 28 empresas, el 57% de las existentes y alrededor de 162 obreras.

  20. Disidir el régimen de horror y muerte: colectivos juveniles femeninos en Ciudad Juárez (México

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    Salvador Salazar Gutiérrez

    2017-01-01

    Full Text Available El texto muestra algunos hallazgos en torno al análisis de acciones colectivas en Ciudad Juárez (México, las cuales plantean una serie de estrategias para develar y disentir del régimen de horror y muerte caracterizado por la violencia durante las dos últimas décadas. Por medio de un trabajo etnográico con los colectivos Batallones Femeninos y Nuestras Hijas de Regreso a Casa, presenta cómo prácticas organizativas asociadas con la música o a la intervención urbana de murales son estrategias para promover una ética por la vida en relación con mujeres jóvenes.

  1. Puebla Territory-Specific Basket of Goods Strategies and Their Local Repercussions for Employment and Profit: the Case of Xicotepec de Juárez, Puebla

    Directory of Open Access Journals (Sweden)

    Mario del Roble Pensado Leglise

    2015-07-01

    Full Text Available Developing a basket of land goods means a systemic strateg y for small farmers because it allows reaching multiple objectives in order to promote territorial competitiveness to access market niches with varied rural goods, strengthen social capital and generate better local levels in employment and income, together with increasing and preserving the environment. This analysis implied the application of a system dynamics model which produced possible future scenarios (through Ve n s i m®DSS 5.8 about employment and income obtained by smallholder coffee farmers from Xicotepec de Juárez municipality in Puebla, regarding the setting of the above mentioned strateg y for rural development. Results showed that this strateg y was implemented successfully and also revealed opportunities for: a improving the development capacity of small farmers; b making the institutional context favorable; c The reinforcement of social capital essential to implement this land strategy.

  2. Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

    Energy Technology Data Exchange (ETDEWEB)

    Sakaguchi, Masanori; Netsu, Kiminori (Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine); Kawarada, Kazuo; Yachiyama, Hitoshi

    1990-08-01

    Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author).

  3. VARIABILITY AT THE EDGE: OPTICAL NEAR/IR RAPID-CADENCE MONITORING OF NEWLY OUTBURSTING FU ORIONIS OBJECT HBC 722

    International Nuclear Information System (INIS)

    Green, Joel D.; Robertson, Paul; Pak, Soojong; Meschiari, Stefano; Baek, Giseon; Lee, Jeong-Eun; Pooley, David; Im, Myungshin; Jeon, Yiseul; Choi, Changsu

    2013-01-01

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from >42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1 m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8-day (0.044 mag amplitude) and 1.28-day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random 'flickering', magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming that the 5.8-day period is due to stellar rotation and the 1.28-day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R * ), we derive a B-field strength of 2.2-2.7 kG, slightly larger than typical T Tauri stars. If instead the 5.8-day signal is from a disk asymmetry, the instability region has an outer radius of 5.4 R * , consistent with models of FUor disks. Further exploration of the time domain in this complicated source and related objects will be key to understanding accretion processes.

  4. Technical note: Fu-Liou-Gu and Corti-Peter model performance evaluation for radiative retrievals from cirrus clouds

    Science.gov (United States)

    Lolli, Simone; Campbell, James R.; Lewis, Jasper R.; Gu, Yu; Welton, Ellsworth J.

    2017-06-01

    We compare, for the first time, the performance of a simplified atmospheric radiative transfer algorithm package, the Corti-Peter (CP) model, versus the more complex Fu-Liou-Gu (FLG) model, for resolving top-of-the-atmosphere radiative forcing characteristics from single-layer cirrus clouds obtained from the NASA Micro-Pulse Lidar Network database in 2010 and 2011 at Singapore and in Greenbelt, Maryland, USA, in 2012. Specifically, CP simplifies calculation of both clear-sky longwave and shortwave radiation through regression analysis applied to radiative calculations, which contributes significantly to differences between the two. The results of the intercomparison show that differences in annual net top-of-the-atmosphere (TOA) cloud radiative forcing can reach 65 %. This is particularly true when land surface temperatures are warmer than 288 K, where the CP regression analysis becomes less accurate. CP proves useful for first-order estimates of TOA cirrus cloud forcing, but may not be suitable for quantitative accuracy, including the absolute sign of cirrus cloud daytime TOA forcing that can readily oscillate around zero globally.

  5. Gauge-theoretic invariants for topological insulators: a bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    Science.gov (United States)

    Monaco, Domenico; Tauber, Clément

    2017-07-01

    We establish a connection between two recently proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant FKM\\in Z_2, arising in the context of two-dimensional time-reversal symmetric topological insulators. On the one hand, the Z_2 invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes, it is possible to provide an expression for FKM containing the square root of the Wess-Zumino amplitude for a certain U( N)-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above-mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields T^2 → U(N), of which we provide a proof employing only basic homotopy theory and circumventing the language of bundle gerbes.

  6. A randomized controlled trial of Kung Fu training for metabolic health in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2009-07-01

    Twenty overweight/obese adolescents underwent six months of Kung Fu or placebo (Tai Chi) training, 3x.wk(-1). Outcomes included fasting insulin and insulin resistance, lipids, glucose and HbA(1c), and C-reactive protein (CRP). CRP decreased significantly (p = 0.03) in both groups over time at six months. Although insulin sensitivity did not change, HbA(1c) tended to decrease over time (p = 0.09), again with no group difference (p = 0.60). Reduced CRP was related to increased upper body strength (p = 0.01). Increased lean body mass was related to reductions in HbA(1c), insulin resistance, triglycerides, and total cholesterol. Improvements in lean body mass appear to have a potential role in favorable metabolic outcomes, independent of changes in fat mass. Further research in this area is warranted before definite conclusions can be drawn about the efficacy of martial arts training for metabolic outcomes in this cohort.

  7. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Directory of Open Access Journals (Sweden)

    Tracey W. Tsang

    2010-01-01

    Full Text Available Aim. To examine the efficacy of a six-month Kung Fu (KF program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7±27.8%. At follow-up, the cohort improved in absolute upper (P=.002 and lower (P=.04 body strength, and upper body muscle endurance (P=.02, without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P=.03, lower body muscle endurance (P=.28; significant 95% CI: 0.37–2.49, and upper body muscle velocity (P=.03 relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  8. I Am the Invincible Sword Goddess: Mediatization of Chinese Gender Ideology through Female Kung-Fu Practitioners in Films

    Directory of Open Access Journals (Sweden)

    Mie Hiramoto

    2014-09-01

    Full Text Available The media are avid portrayers of gender binarism and the belief in male-female distinctions, which are mainly attributed to perceived differences of a physical nature. In this paper, we investigate representations of female kung-fu practitioners (nuxia in films to discuss how processes of mediation and mediatization depict their femininity, so as to mitigate their appropriation of Chinese martial arts masculinity. Often, nuxias are portrayed as empowered women who are equipped to take control of their own lives and to courageously take on challenges from a variety of opponents. However, multimodal deconstruction of the various characteristics of nuxias must be placed in an Asian-specific context in order to understand the femininity specific to these characters and to move beyond Western gender ideologies displayed by the media. Perpetuating Confucian patriarchal ideals, nuxia roles constantly and consistently associate conformation to Confucian values with virtuousness and non-conformation with wickedness. We therefore can use the ideals of Confucianism as a more accurate foundation in deconstructing the identities of nuxias, which allows us to better understand the mediation and mediatization processes of ideologies associated with Chinese femininity and masculinity in martial arts films.

  9. Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

    International Nuclear Information System (INIS)

    Sakaguchi, Masanori; Netsu, Kiminori; Kawarada, Kazuo; Yachiyama, Hitoshi.

    1990-01-01

    Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author)

  10. ELECTROMYOGRAPHIC STUDY OF A SEQUENCE OF YAU-MAN KUNG FU PALM STRIKES WITH AND WITHOUT IMPACT

    Directory of Open Access Journals (Sweden)

    Osmar Pinto Neto

    2007-10-01

    Full Text Available In martial arts and contact sports, strikes are often trained in two different ways: with and without impacts. This study aims to compare the electromyographical activity (EMG of the triceps brachii (TB, biceps brachii (BB and brachioradialis (BR muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms and frequency (wavelet domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar

  11. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin.

    Science.gov (United States)

    Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

    2017-12-19

    Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the endosomal/lysosomal-localizing photosensitizer TPCS 2a (fimaporfin) combined with light (photochemical treatment, PCT) using MTS viability assay, and used fluorescence microscopy to show localization of TPCS 2a and to investigate the effect of photodamage of lysosomes. Flow cytometric analysis was performed to investigate uptake of photosensitizer and to assess intracellular ROS levels. Expression and localization of LAMP1 was assessed using RT-qPCR, western blotting, and structured illumination microscopy. MTS viability assay was used to assess the effect of combinations of 5-FU, chloroquine (CQ), and photochemical treatment. Expression of CD105 was investigated using RT-qPCR, western blotting, flow cytometry, and fluorescence microscopy, and co-localization of TPCS 2a and anti-CD105-saporin was assessed using microscopy. Lastly, the MTS assay was used to investigate cytotoxic effects of photochemical internalization (PCI) of the anti-CD105-immunotoxin. The 5-FUR cell lines display hypersensitivity to PCT, which was linked to increased uptake of TPCS 2a , altered lysosomal distribution, lysosomal photodamage and increased expression of the lysosomal marker LAMP-1 in the 5-FUR cells. We show that inhibition of autophagy induced by either chloroquine or lysosomal photodamage increases the sensitivity to 5-FU in the resistant cells. The three 5-FUR sub-clones overexpress Endoglin (CD105). Treatment with the immunotoxin anti-CD105-saporin alone significantly reduced the viability of the CD105

  12. Review of dissertation The Association Of Intelligence, Visual-Motor Functioning, And Personality Characteristics With Adaptive Behavior In Individuals With Williams Syndrome by Juhsin Trista Fu

    Directory of Open Access Journals (Sweden)

    Florova N.B.

    2015-06-01

    Full Text Available Juhsin Trista Fu (Taiwan is an American clinical psychologist, doctor of philosophy (PhD, on the national register of health professionals of United States National Provider Identifiers (NPI Registry. The proposed material gives a systematic description of the dynamics of specific behavioral construct in adults in situation of genetic anomalies. The author regards this condition as a volatile state which to a certain extent responds to interventions.

  13. Profesionālā sociālā tīkla LinkedIn izmantojums Latvijā: darba devēju un darba ņēmēju lietošanas motivācijas analīze

    OpenAIRE

    Jaunzeme, Maija

    2013-01-01

    Bakalaura tēma ir „Profesionālā sociālā tīkla LinkedIn izmantojums Latvijā: darba devēju un darba ņēmēju lietošanas motivācijas analīze”. Darba mērķis ir noskaidrot darba ņēmēja un darba devēja motīvus sociālā tīkla LinkedIn izmantošanai. Problēmjautājums bija noskaidrot, kā tīkls maina lietošanas paradumus lietotājam, meklējot darba vietu vai darbinieku? Teorētiskajā daļā tika analizēta lietojuma un apmierinājuma teorija sociālajiem tīkliem un LinkedIn auditorijai. Ar aptaujas palīdzību t...

  14. EFECTO DEL GRITO COMO UN RECURSO ERGOGÉNICO PSICOLÓGICO EN PRACTICANTES DE KUNG FU

    Directory of Open Access Journals (Sweden)

    Juan Diego Zamora Salas

    2002-12-01

    Full Text Available El presente estudio analizó el efecto del grito como mecanismo inhibidor de sensaciones como el dolor y la fatiga enpracticantes de Kung Fu, utilizando una prueba de push ups. Se formaron tres grupos de forma aleatoria,cada uno conformado por n= 10, cuyas edades estaban comprendidas entre los 15 y 30 años. Los sujetos del Grupo Experimental sin grito y Grupo Experimental con grito, les correspondía realizar las prácticas depush ups aplicando los tratamientos correspondientes durante cinco semanas; mientras que los sujetos delgrupo control no realizaban éstas prácticas durante el período establecido, sólo les correspondía el pre-testy post-test. A los valores recolectados durante las pruebas se les aplicó una Anova 3 x 2 y un análisis posthocde la interacción mostrando la existencia de una diferencia significativa entre el pre-test y el post-testtanto en el grupo que aplicó el grito personal como en el grupo que no lo aplicó, lo cual no se manifestóentre el pre-test y post-test del grupo control. Al comparar los datos obtenidos del grupo que utilizó el gritopersonal con respecto al grupo que no utilizó el grito como tratamiento, se encontró una diferenciasignificativa entre ambos métodos. Con el estudio se concluyó que el grito en combinación con el ejerciciofísico permite observar incrementos significativos en la cantidad de repeticiones de un ejercicio de fuerzapara el tren superior como son las push ups, luego de cinco semanas de tratamiento.

  15. Antibacterial Activity of Copper Oxide (CuO Nanoparticles Biosynthesized by Bacillus sp. FU4: Optimization of Experiment Design

    Directory of Open Access Journals (Sweden)

    Mojtaba Taran, Maryam Rad, Mehran Alavi

    2017-09-01

    Full Text Available Background: There are several methods for synthesis of metallic nanoparticles (NPs including chemical, physical and biological process. In this study, Bacillus sp. FU4 was used as biological source for biosynthesis of CuO NPs. Methods: CuO NPs have been prepared by copper sulfate (CuSO4. CuO NPs were formed after oxidation of Cu NPs. Design and analysis of Taguchi experiments (an orthogonal assay and analysis of variance (ANOVA carried out by the Qualitek-4 software. Average effect of CuSO4 concentration (0.1, 0.01 and 0.001 M, incubation and culturing time (48, 72, 96 hours as three controllable factors with three levels were evaluated in CuO NPs biosynthesis. Characterization of CuO NPs was determined by UV-Vis spectroscopy, X-ray diffraction (XRD, Fourier transform infra-red (FT-IR spectroscopy and scanning electron microscopy (SEM. Also, the antimicrobial properties of CuO NPs were investigated using Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 43300 as multidrug resistant (MDR bacteria. Results: Results: It was evaluated that, NPs size distributions were in the range of 2-41 nm with spherical shapes. The anti-bacterial activities of CuO NPs were measured based on diameter of inhibition zone in disk diffusion tests of NPs dispersed in batch cultures. Two levels of CuSO4 concentrations (0.1 and 0.01M had antibacterial effect on E.coli (33±0.57 and 6 ±2mm. In the case of S. aureus, there was surprisingly no sign of growth. Conclusion: CuO NPs have antibacterial activity that can be benefit in medicinal aspect for fighting against prominent pathogen bacteria such as E.coli ATCC 25922 and S.aureus ATCC 43300.

  16. Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: Adjuvant 5-FU/cisplatin and chemoradiation with capecitabine

    Science.gov (United States)

    Lee, Hyung-Sik; Choi, Youngmin; Hur, Won-Joo; Kim, Hyo-Jin; Kwon, Hyuk-Chan; Kim, Sung-Hyun; Kim, Jae-Seok; Lee, Jong-Hoon; Jung, Ghap-Joong; Kim, Min-Chan

    2006-01-01

    AIM: To evaluate the efficacy and toxicity of postoperative chemoradiation using FP chemotherapy and oral capecitabine during radiation for advanced gastric cancer following curative resection. METHODS: Thirty-one patients who had underwent a potentially curative resection for Stage III and IV (M0) gastric cancer were enrolled. Therapy consists of one cycle of FP (continuous infusion of 5-FU 1000 mg/m2 on d 1 to 5 and cisplatin 60 mg/m2 on d 1) followed by 4500 cGy (180 cGy/d) with capecitabine (1650 mg/m2 daily throughout radiotherapy). Four wk after completion of the radiotherapy, patients received three additional cycles of FP every three wk. The median follow-up duration was 22.2 mo. RESULTS: The 3-year disease free and overall survival in this study were 82.7% and 83.4%, respectively. Four patients (12.9%) showed relapse during follow-up. Eight patients did not complete all planned adjuvant therapy. Grade 3/4 toxicities included neutropenia in 50.2%, anemia in 12.9%, thrombocytopenia in 3.2% and nausea/vomiting in 3.2%. Neither grade 3/4 hand foot syndrome nor treatment related febrile neutropenia or death were observed. CONCLUSION: These preliminary results suggest that this postoperative adjuvant chemoradiation regimen of FP before and after capecitabine and concurrent radiotherapy appears well tolerated and offers a comparable toxicity profile to the chemoradiation regimen utilized in INT-0116. This treatment modality allowed successful loco-regional control rate and 3-year overall survival. PMID:16489675

  17. Therapeutic effects of FuZhiSan on Alzheimer's disease rat model:evaluation with PET imaging

    International Nuclear Information System (INIS)

    Guo Zhe; Zhang Jinming; Yao Shulin; Feng Huiru; Li Xuling; Yin Dayi; Tian Jiahe

    2010-01-01

    Objective: To assess the feasibility of using PET molecular imaging to evaluate the therapeutic effects of traditional Chinese medicine FuZhiSan (FZS) on the model of aging Alzheimer's disease (AD) rats. Methods: Twenty aged AD rats (Sparague-Dawley rats,male) were randomly divided into FZS treated group (n = 10) and control group (n = 10). Another 10 healthy adult rats were as blank controls. Morris water maze record system was used for cognitive function assessment. Before and after FZS treatment 18 F-fluorodeoxyglucose (FDG) and 11 C-2- [4'-(methylamino) phenyl] benzothiazol-6-ol (PIB) PET imaging was undertaken. After post-treatment imaging procedures the brain tissues of all animals were taken for histochemical study, such as staining with HE, congo red, amyloid β (Aβ) immunofluorescence, 5-bromo-2-deoxyuridine (BrdU) immunofluorescence and NeuN immunofluorescence. Paired t-test was performed with SPSS 13.0 software for the data analysis. Results: The cognitive dysfunction of aging AD rats was improved after FZS treatment. The escape latency in FZS treated group was significantly shorter than that of control group ((32.5 ±10.8) s vs (102.6±8.8) s, t =15.7987, P=0. 0001). Diffuse neuronal loss and Aβ deposition were detected in the hippocampus and cortex in the aged AD rats. The imaging data showed that brain glucose metabolism was amended in FZS treated group while the abatement of amyloid deposition was not significant. Immunofluorescence results indicated that the neuronal proliferation was more remarkable in FZS treated group. Conclusions: It may be feasible to use PET imaging as a method to evaluate the therapeutic effect in AD rats. FZS may ameliorate memory dysfunction of aged AD rats. Its mechanism may be partly contributed to the enhancement of the neuronal proliferation and survival. (authors)

  18. Kung Fu a jeho zařazení do výuky úpolů ve školní tělesné výchově

    OpenAIRE

    Krbcová, Pavlína

    2015-01-01

    The goal of this thesis is to analyse kung fu from the pespective of teaching Combatives in Physicial Education courses, suggest model exercises with the help of the consultants named in the theoretical part and create model lessons that teachers may use in their Physical Education courses. The teoretical part focuses on history, taxonomy and teaching of Combatives in Physical Education courses. In addition, in describes history, characteristics and taxonomy of kung fu. The experimental part ...

  19. Concurrent hyperfractionated accelerated radiotherapy with 5-FU and once weekly cisplatin in locally advanced head and neck cancer. The 10-year results of a prospective phase II trial

    Energy Technology Data Exchange (ETDEWEB)

    Budach, V.; Boehmer, D.; Badakhshi, H.; Jahn, U.; Stromberger, C. [Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Department for Radiooncology, Clinic for Radiooncology, Berlin (Germany); Becker, E.T. [Charite Universitaetsmedizin, Department of Otorhinolaryngology, Berlin (Germany); Wernecke, K.D. [Sostana Statistics GmbH, Charite Universitaetsmedizin Berlin, Berlin (Germany)

    2014-03-15

    In this study, the acute toxicity and long-term outcome of a hyperfractionated accelerated chemoradiation regimen with cisplatin/5-fluorouracil (5-FU) in patients with locally advanced squamous cell carcinomas of head and neck were evaluated. From 2000-2002, 38 patients with stage III (5.3 %) and stage IV (94.7 %) head and neck cancer were enrolled in a phase II study. Patients received hyperfractionated-accelerated radiotherapy with 72 Gy in 15 fractions of 2 Gy followed by 1.4 Gy twice daily with concurrent, continuous infusion 5-FU of 600 mg/m{sup 2} on days 1-5 and 6 cycles of weekly cisplatin (30 mg/m{sup 2}). Acute toxicities (CTCAEv2.0), locoregional control (LRC), metastases-free (MFS), and overall survival (OS) were analyzed and exploratively compared with the ARO 95-06 trial. Median follow-up was 11.4 years (95 % CI 8.6-14.2) and mean dose 71.6 Gy. Of the patients, 82 % had 6 (n = 15) or 5 (n = 16) cycles of cisplatin, 5 and 2 patients received 4 and 3 cycles, respectively. Grade 3 anemia, leukopenia, and thrombocytopenia were observed in 15.8, 15.8, and 2.6 %, respectively. Grade 3 mucositis in 50 %, grade 3 and 4 dysphagia in 55 and 13 %. The 2-, 5-, and 10-year LRC was 65, 53.6, and 48.2 %, the MFS was 77.5, 66.7, and 57.2 % and the OS 59.6, 29.2, and 15 %, respectively. Chemoradiation with 5-FU and cisplatin seems feasible and superior in terms of LRC and OS to the ARO 95-06C-HART arm at 2 years. However, this did not persist at the 5- and 10-year follow-ups. (orig.) [German] Untersuchung der Akuttoxizitaet und des Langzeitueberlebens einer hyperfraktioniert-akzelerierten simultanen Radiochemotherapie mit Cisplatin/5-Fluorouracil (5-FU) bei Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren. Von 2000 bis 2002 wurden 38 Patienten mit Plattenepithelkarzinomen der Kopf-Hals-Region im Stadium III (5,3 %) und IV (94,7 %) eingeschlossen. Es erfolgte eine simultane hyperfraktionierte akzelerierte Radiochemotherapie mit 72 Gy in 15 Fraktionen a 2 Gy

  20. K3FU METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  1. Quantum kung fu

    Science.gov (United States)

    Flicker, Felix

    2014-07-01

    If someone puts you in an armlock, what should you do? If you happen to be a martial artist well-practised in the art of joint manipulation, or chin na, you will know the answer already: there is one simple move that will allow you to turn the tables on your aggressor, leaving them on the wrong end of a throw.

  2. Relación entre consultas a urgencias por enfermedad respiratoria y contaminación atmosférica en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Hernández-Cadena Leticia

    2000-01-01

    Full Text Available OBJETIVO: Analizar la relación entre las concentraciones ambientales de partículas de diámetro <=10 µm (PM10 y de ozono con el número diario de consultas al servicio de urgencias por enfermedades respiratorias agudas y asma en niños menores de 15 años, residentes de Ciudad Juárez, Chihuahua, México. MATERIAL Y MÉTODOS: Este estudio se realizó durante los años de 1998 y 1999, utilizando un diseño de tipo ecológico. Los datos atmosféricos se obtuvieron de la base de datos de la Agencia de Protección al Ambiente (EPA, provenientes de ocho estaciones de monitoreo ubicadas en Ciudad Juárez y en El Paso, Texas. Los datos de consultas al servicio de urgencias por causas respiratorias se obtuvieron de los registros médicos de dos hospitales del Instituto Mexicano del Seguro Social (IMSS, en Ciudad Juárez, Chihuahua, de julio de 1997 a diciembre de 1998. Los diagnósticos se clasificaron en dos grupos: a asma, y b infecciones respiratorias altas, conforme a la Clasificación Internacional de Enfermedades (CIE-9 o CIE-10. El análisis se realizó con la utilización de la metodología de series de tiempo que emplea regresión Poisson. RESULTADOS: Durante el periodo de estudio la media de 24 horas de PM10 fue de 34.46 µg/m³ (DE=17.99 y la media de los niveles de ozono fue de 51.60 partes por billón (ppb (DE=20.70. El modelo propuesto estima que un incremento de 20 µg/m³ en el promedio de 24 horas, en la exposición a PM10, se relaciona con un incremento de 4.97% (IC 95% 0.97-9.13 en las consultas por asma con un retraso de cinco días y con un incremento de 9% (IC 95% 1.8-16.8 cuando se considera a la exposición acumulada de cinco días anteriores. Respecto a enfermedades respiratorias altas se encontró un aumento de 2.95% en las consultas a urgencias por cada 20 µm/m³ de incremento en el promedio de 24 horas en la exposición a PM10. Se observó que el impacto de PM10 sobre las visitas de urgencia por asma fue más severo en

  3. [Isolation and characterization of petroleum catabolic broad-host-range plasmids from Shen-Fu wastewater irrigation zone].

    Science.gov (United States)

    Wang, Ya-Fei; Wang, Ya-Fei; Li, Hui; Li, Xiao-Bin

    2013-11-01

    Based on triparental mating, we isolated a total of eight broad host range (BHR) petroleum hydrocarbon catabolic plasmids from the soils, sediments, and wastewater samples in the Shen-Fu irrigation zone. The antibiotic resistance of the plasmids was tested, and then, the plasmids were transferred to Escherichia coli EC100. The plasmids carrying no antibiotic resistance were tagged by miniTn5 transposon consisting of antibiotic resistant genes. The PCR-based incompatibility test revealed that the pS3-2C and pS4-6G belonged to Inc P group, the pS3-2G, pW22-3G, and pA15-7G belonged to Inc N group, the pS7-2G was identified as Inc W plasmid, and the pA23-1G and pA10-1C were placed into Inc Q group. By adopting the reported PCR amplification methods of petroleum hydrocarbon-degrading catabolic genes, the petroleum-degrading capability of these BHR plasmids were preliminarily analyzed. The plasmids pS3-2G, pS7-2G, pA23-1G, pW22-3G, and pA10-1C carried aromatic ring- hydroxylating dioxygenase gene phdA and toluene monooxygenase gene touA; the plasmid pA15-7G carried touA and toluene dioxygenase gene tod; the plasmid pS3-2C carried ben, phdA, and tod; whereas the pS4-6G only carried ben. The host range test showed that all the isolated plasmids except pS3-2C could be transferred and maintained stably in the representative strains Agrobacterium tumefaciens C58, Cupriavidus necator JMP228, and E. coli EC100 of the alpha-, beta-, and gamma-Proteobacteria, respectively.

  4. Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways

    Directory of Open Access Journals (Sweden)

    Chen J

    2014-07-01

    Full Text Available Jiezhong Chen,1,2 Renfu Shao,3 Li Li,4 Zhi Ping Xu,4 Wenyi Gu4 1School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, 2Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, 3GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland, 4Australian Institute of Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia Abstract: Colon cancer is the third most common cancer and the third largest cause of cancer-related death. Fluorouracil (5-FU is the front-line chemotherapeutic agent for colon cancer. However, its response rate is less than 60%, even in combination with other chemotherapeutic agents. The side effects of 5-FU also limit its application. Nanoparticles have been used to deliver 5-FU, to increase its effectiveness and reduce side effects. Another common approach for colon cancer treatment is targeted therapy against the phosphoinositide 3-kinase (PI3K/protein kinase B (Akt pathway. A recently-invented inhibitor of this pathway, BEZ-235, has been tested in several clinical trials and has shown effectiveness and low side effects. Thus, it is a very promising drug for colon cancer treatment. The combination of these two drugs, especially nanoparticle-packed 5-FU and BEZ-235, has not been studied. In the present study, we demonstrated that nanoparticles of layered double hydroxide (LDH loaded with 5-FU were more effective than a free drug at inhibiting colon cancer cell growth, and that a combination treatment with BEZ-235 further increased the sensitivity of colon cancer cells to the treatment of LDH-packed 5-FU (LDH-5-FU. BEZ-235 alone can decrease colon cancer HCT-116 cell viability to 46% of the control, and the addition of LDH-5-FU produced a greater effect, reducing cell survival to 8% of the control. Our data indicate that the combination therapy of

  5. Progressive degradation in a-Si: H/SiN thin film transistors

    NARCIS (Netherlands)

    Merticaru, A.R.; Mouthaan, A.J.; Kuper, F.G.

    2003-01-01

    In this paper we present the study of gate-stress induced degradation in a-Si:H/SiN TFTs. The drain current transient during gate bias stress (forward or reverse bias) and subsequent relaxation cannot be fitted with the models existent in the literature but it shows to be described by a progressive

  6. Zīmola vērtība no patērētāju perspektīvas sporta apģerbu un apavu tirgū.

    OpenAIRE

    Kadakovska, Agnese

    2017-01-01

    Bakalaura darba tēma ir “Zīmola vērtība no patērētāju perspektīvas sporta apģērbu un apavu tirgū”. Bakalaura darba mērķis ir pamatojoties uz izpētīto teorētisko informāciju par zīmola vērtības no patērētāju perspektīvas veidošanu, identificēt patērētāju skatījumā vērtīgākos sporta apģērbu un apavu tirgus zīmolus Latvijā un izstrādāt priekšlikumus to vērtības palielināšanai. Bakalaura darbs sastāv no ievada, 3 nodaļām, secinājumiem un priekšlikumiem, izmantotās literatūras saraksta un pielikum...

  7. Seguridad urbana y vulnerabilidad social en Ciudad Juárez. Un modelo desde la perspectiva de análisis espacial

    Directory of Open Access Journals (Sweden)

    Sara Morales Cárdenas

    2013-01-01

    Full Text Available Partiendo del concepto de “seguridad urbana”, introducido por un-Habitat en 2007 dentro de la agenda de Ciudades seguras, el presente trabajo propone analizar a Ciudad Juárez, urbe considerada entre las más inseguras y violentas del país y del mundo. Se presenta el desarrollo de un índice de seguridad urbana (isu basado en un modelo multicriterio de análisis espacial que propone identificar y explicar cómo se manifiestan territorialmente las amenazas a la seguridad urbana y su relación con los índices de vulnerabilidad social asociada a la pobreza. La importancia de este análisis radica en la necesidad de articular los estudios estadísticos y los patrones de distribución de las amenazas a la seguridad urbana con los procesos de planificación urbana como instrumento preventivo que permita formular políticas para reducir la inseguridad urbana.

  8. Elaboración del duelo de una madre cuyo hijo trabajaba como sicario en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Rosalía Delgado Durán

    2014-01-01

    Full Text Available El presente trabajo es parte de una investigación cualitativa sobre el proceso de ela - boración de duelo de la madre de un sicario en el contexto de una terapia Gestalt. Se utilizó para su análisis la perspectiva de las etapas del duelo de Kübler-Ross (2006:59- 119. La exacerbación de la violencia generada en buena medida por pugnas entre gru - pos del crimen organizado en Ciudad Juárez, Chihuahua (Martínez, 2008, ha dado como resultado una gran cantidad de muertes, una de ellas es el caso que nos ocupa. Si bien uno de los objetivos iniciales de la investigación era documentar y analizar las etapas en el desarrollo del duelo de una madre a partir del fallecimiento de su hijo, este se replanteó durante el transcurso de la misma, ya que una de las características del duelo de esta madre es que inició justo cuando se enteró del trabajo que él realizaba.

  9. Paula Stradiņa Medicīnas vēstures muzeja apmeklētāju sastāvs (2007–2011

    Directory of Open Access Journals (Sweden)

    Lienīte Šarkūna

    2016-12-01

    Full Text Available 2007. gadā Paula Stradiņa Medicīnas vēstures muzejs svinēja 50 gadu pastāvēšanas jubileju. Kopš tā laika muzeja piedāvājumu klāsts ir paplašinājies un mainījies, tāpat mainījies ir arī muzeja apmeklētājs. Šodien arvien vairāk apmeklētāju, nākot uz muzeju, ir iepriekš sagatavojušies, ieguvuši informāciju par muzeju tā mājaslapā www.mvm.lv (izveidota 2003. gadā, reorganizēta 2014. gadā, kā arī sociālajos tīklos: www.twitter.com, http:// www.draugiem.lv/mvm/ un www.facebook.com ( kur muzeja publiskie konti izveidoti 2011. gada oktobrī. Tāpēc arvien svarīgāk ir noskaidrot, kādi ir muzeja apmeklētāji, lai veidotu aktuālu, interesantu un izglītojošu piedāvājumu.

  10. Reklāmas ietekme uz patērētāju izvēles veikšanā

    OpenAIRE

    Asejevs, Aleksandrs

    2012-01-01

    Bakalaura darba tēma izvēlēta „Reklāmas ietekme uz patērētāju izvēles veikšanā”. Pastiprinoties konkurencei valstu iekšzemes tirgū, uzņēmumi savas preces un pakalpojumus virza globālajā tirgū. Starptautiskajā mārketingā reklāma tiek izmantota kā viens no mārketinga komunikācijas līdzekļiem, ar kura palīdzību uzņēmumi patērētajiem virzītu savas preces un pakalpojumus. Darba mērķis: balstoties uz veiktās aptaujas rezultātiem, izstrādāt priekšlikumus reklāmas pilnveidošanai Latvijā. Lai...

  11. Gestión pública para solucionar un problema ambiental: manejo de llantas de desecho en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Gustavo Córdova Bojórquez

    2012-01-01

    Full Text Available La reutilización de llantas usadas es un problema ambiental cuando ya no es posible seguirlas usando y se consideran basura, que se almacena en casas, se deposita en tiraderos clandestinos y se tira en la vía pública. Se convierten en refugio de plagas, roedores e insectos vectores de enfermedades, además constituyen un riesgo para el entorno y la salud humana, peligro que se incrementa ante la posibilidad de un incendio. El objetivo del presente trabajo es analizar la gestión del manejo de la llanta de desecho en Ciudad Juárez, Chihuahua, hogar del mayor tiradero de llantas en la región fronteriza. Los resultados muestran que el gobierno ha tenido una participación mínima, hasta el momento en que se inicia un proceso de gestión mixta que involucra además al sector privado, al académico y a la sociedad civil; a partir de esta gestión mixta comienzan realmente acciones específicas para resolver el problema de la llanta usada.

  12. A Hydrological Tomography Collocated with Time-varying Gravimetry for Hydrogeology -An Example in Yun-Lin Alluvial Plain and Ming-Ju Basin in Taiwan

    Science.gov (United States)

    Chen, K. H.; Cheng, C. C.; Hwang, C.

    2016-12-01

    A new inversion technique featured by the collocation of hydrological modeling and gravimetry observation is presented in this report. Initially this study started from a project attempting to build a sequence of hydrodynamic models of ground water system, which was applied to identify the supplement areas of alluvial plains and basins along the west coast of Taiwan. To calibrate the decent hydro-geological parameters for the modeling, geological evolution were carefully investigated and absolute gravity observations, along with other on-site hydrological monitoring data were specially introduced. It was discovered in the data processing that the time-varying gravimetrical data are highly sensitive to certain boundary conditions in the hydrodynamic model, which are correspondent with respective geological features. A new inversion technique coined by the term "hydrological tomography" is therefore developed by reversing the boundary condition into the unknowns to be solved. An example of accurate estimate for water storage and precipitation infiltration of a costal alluvial plain Yun-Lin is presented. In the mean time, the study of an anticline structure of the upstream basin Ming-Ju is also presented to demonstrate how a geological formation is outlined when the gravimetrical data and hydrodynamic model are re-directed into an inversion.

  13. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

    Directory of Open Access Journals (Sweden)

    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  14. Neoadjuvant Treatment With Single-Agent Cetuximab Followed by 5-FU, Cetuximab, and Pelvic Radiotherapy: A Phase II Study in Locally Advanced Rectal Cancer

    International Nuclear Information System (INIS)

    Bertolini, Federica; Chiara, Silvana; Bengala, Carmelo; Antognoni, Paolo; Dealis, Cristina; Zironi, Sandra; Malavasi, Norma; Scolaro, Tindaro; Depenni, Roberta; Jovic, Gordana; Sonaglio, Claudia; Rossi, Aldo; Luppi, Gabriele; Conte, Pier Franco

    2009-01-01

    Purpose: Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging. Methods and Materials: After biopsy and staging, uT3/uT4 N0/+ LARC received single-agent cetuximab in three doses, followed by weekly cetuximab plus 5-fluorouracil (5-FU), concomitantly with RT. Sample size was calculated according to Bryant and Day test, a two-stage design with at least 10 pathologic complete remissions observed in 60 patients (pts) able to complete the treatment plan. Results: Forty pts with LARC were entered: male/female = 34/6; median age: 61 (range, 28-77); 12 uT3N0 Ed(30%); 25 uT3N1 (62%); 3 uT4N1 (8%); all Eastern Cooperative Oncology Group = 0. Thirty-five pts completed neoadjuvant treatment; 5 (12%) withdrew therapy after one cetuximab administration: three for hypersensitivity reactions, one for rapid progression, and one for purulent arthritis. They continued 5-FU in continuous infusion in association with RT. Thirty-one pts (77%) presented with acnelike rash; dose reduction/interruption of treatment was necessary in six pts (15%): two for Grade 3 acnelike rash, two for Grade 3 gastrointestinal toxicity, and two for refusal. Thirty-eight pts were evaluable for pathological response (one patient refused surgery, and one was progressed during neoadjuvant treatment). Pathological staging was: pT0N0 three pts (8%), pT1N0 1 pt (3%); pT2N0 13 pts (34%), and pT3 19 pts (50%) (N0:9, N1:5; N2:5); pT4 2 pts (5%). Conclusions: Preoperative treatment with 5-FU, cetuximab, and pelvic RT is feasible with acceptable toxicities; however, the rate of pathologic responses is disappointingly low

  15. The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer

    International Nuclear Information System (INIS)

    Baglan, Kathy L.; Frazier, Robert C.; Yan Di; Huang, Raywin R.; Martinez, Alvaro A.; Robertson, John M.

    2002-01-01

    Purpose: A direct relationship between the volume of small bowel irradiated and the degree of acute small bowel toxicity experienced during concurrent 5-fluorouracil (5-FU)-based chemoradiotherapy for rectal carcinoma is well recognized but poorly quantified. This study uses three-dimensional treatment-planning tools to more precisely quantify this dose-volume relationship. Methods and Materials: Forty patients receiving concurrent 5-FU-based chemotherapy and pelvic irradiation for rectal carcinoma had treatment-planning CT scans with small bowel contrast. A median isocentric dose of 50.4 Gy was delivered using a posterior-anterior and opposed lateral field arrangement. Bowel exclusion techniques were routinely used, including prone treatment position on a vacuum bag cradle to allow anterior displacement of the abdominal contents and bladder distension. Individual loops of small bowel were contoured on each slice of the planning CT scan, and a small bowel dose-volume histogram was generated for the initial pelvis field receiving 45 Gy. The volume of small bowel receiving each dose between 5 and 40 Gy was recorded at 5-Gy intervals. Results: Ten patients (25%) experienced Common Toxicity Criteria Grade 3+ acute small bowel toxicity. A highly statistically significant association between the development of Grade 3+ acute small bowel toxicity and the volume of small bowel irradiated was found at each dose level. Specific dose-volume threshold levels were found, below which no Grade 3+ toxicity occurred and above which 50-60% of patients developed Grade 3+ toxicity. The volume of small bowel receiving at least 15 Gy (V 15 ) was strongly associated with the degree of toxicity. Univariate analysis of patient and treatment-related factors revealed no other significant predictors of severe toxicity. Conclusions: A strong dose-volume relationship exists for the development of Grade 3+ acute small bowel toxicity in patients receiving concurrent 5-FU-based chemoradiotherapy

  16. Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

    Directory of Open Access Journals (Sweden)

    Sun Xiao-Feng

    2010-11-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31 is obviously up-regulated in colorectal cancer (CRC, there is no study on the functional roles of miR-31 in CRC. Methods Anti-miR™ miRNA 31 inhibitor (anti-miR-31 is a sequence-specific and chemically modified oligonucleotide to specifically target and knockdown miR-31 molecule. The effect of anti-miR-31 transfection was investigated by real-time PCR. HCT-116p53+/+ and HCT-116p53-/-colon cancer cells were treated by anti-miR-31 with or without 5-fluorouracil (5-FU, cell proliferation was determined by MTT assay; apoptosis was detected by DAPI staining; cell cycle was evaluated by flow cytometry; colony formation, migration and invasion assays were performed to investigate the effect of suppression of miR-31 on the cell lines. Results Real-time PCR results showed that anti-miR-31 was efficiently introduced into the cells and reduced miR-31 levels to 44.1% in HCT-116p53+/+ and 67.8% in HCT-116p53-/-cell line (p = 0.042 and 0.046. MTT results showed that anti-miR-31 alone had no effect on the proliferation of HCT-116p53+/+ or HCT-116p53-/-. However, when combined with 5-FU, anti-miR-31 inhibited the proliferation of the two cell lines as early as 24 h after exposure to 5-FU (p = 0.038 and 0.044. Suppression of miR-31 caused a reduction of the migratory cells by nearly 50% compared with the negative control in both HCT-116p53+/+ and HCT-116p53-/-(p = 0.040 and 0.001. The invasive ability of the cells were increased by 8-fold in HCT-116p53+/+ and 2-fold in HCT-116p53-/- (p = 0.045 and 0.009. Suppression of miR-31 had no effect on cell cycle and colony formation (p > 0.05. Conclusions Suppression of miR-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells.

  17. Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects

    Science.gov (United States)

    Gu, B.; Yang, P.; Kuo, C. P.; Mlawer, E. J.

    2017-12-01

    Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects Boyan Gu1, Ping Yang1, Chia-Pang Kuo1, Eli J. Mlawer2 Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA Atmospheric and Environmental Research (AER), Lexington, MA 02421, USA Ice clouds play an important role in climate system, especially in the Earth's radiation balance and hydrological cycle. However, the representation of ice cloud radiative effects (CRE) remains significant uncertainty, because scattering properties of ice clouds are not well considered in general circulation models (GCM). We analyze the strengths and weakness of the Rapid Radiative Transfer Model for GCM Applications (RRTMG) and Fu-Liou Radiative Transfer Model (RTM) against rigorous LBLRTM-DISORT (a combination of Line-By-Line Radiative Transfer Model and Discrete Ordinate Radiative Transfer Model) calculations and CERES (Clouds and the Earth's Radiant Energy System) flux observations. In total, 6 US standard atmospheric profiles and 42 atmospheric profiles from Atmospheric and Environmental Research (AER) Company are used to evaluate the RRTMG and Fu-Liou RTM by LBLRTM-DISORT calculations from 0 to 3250 cm-1. Ice cloud radiative effect simulations with RRTMG and Fu-Liou RTM are initialized using the ice cloud properties from MODIS collection-6 products. Simulations of single layer ice cloud CRE by RRTMG and LBLRTM-DISORT show that RRTMG, neglecting scattering, overestimates the TOA flux by about 0-15 W/m2 depending on the cloud particle size and optical depth, and the most significant overestimation occurs when the particle effective radius is small (around 10 μm) and the cloud optical depth is intermediate (about 1-10). The overestimation reduces significantly when the similarity rule is applied to RRTMG. We combine ice cloud properties from MODIS Collection-6 and atmospheric profiles from the Modern

  18. Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial

    Science.gov (United States)

    Yothers, Greg; O’Connell, Michael J.; Beart, Robert W.; Wozniak, Timothy F.; Pitot, Henry C.; Shields, Anthony F.; Landry, Jerome C.; Ryan, David P.; Arora, Amit; Evans, Lisa S.; Bahary, Nathan; Soori, Gamini; Eakle, Janice F.; Robertson, John M.; Moore, Dennis F.; Mullane, Michael R.; Marchello, Benjamin T.; Ward, Patrick J.; Sharif, Saima; Roh, Mark S.; Wolmark, Norman

    2015-01-01

    Background: National Surgical Adjuvant Breast and Bowel Project R-04 was designed to determine whether the oral fluoropyrimidine capecitabine could be substituted for continuous infusion 5-FU in the curative setting of stage II/III rectal cancer during neoadjuvant radiation therapy and whether the addition of oxaliplatin could further enhance the activity of fluoropyrimidine-sensitized radiation. Methods: Patients with clinical stage II or III rectal cancer undergoing preoperative radiation were randomly assigned to one of four chemotherapy regimens in a 2x2 design: CVI 5-FU or oral capecitabine with or without oxaliplatin. The primary endpoint was local-regional tumor control. Time-to-event endpoint distributions were estimated using the Kaplan-Meier method. Hazard ratios were estimated from Cox proportional hazard models. All statistical tests were two-sided. Results: Among 1608 randomized patients there were no statistically significant differences between regimens using 5-FU vs capecitabine in three-year local-regional tumor event rates (11.2% vs 11.8%), 5-year DFS (66.4% vs 67.7%), or 5-year OS (79.9% vs 80.8%); or for oxaliplatin vs no oxaliplatin for the three endpoints of local-regional events, DFS, and OS (11.2% vs 12.1%, 69.2% vs 64.2%, and 81.3% vs 79.0%). The addition of oxaliplatin was associated with statistically significantly more overall and grade 3–4 diarrhea (P < .0001). Three-year rates of local-regional recurrence among patients who underwent R0 resection ranged from 3.1 to 5.1% depending on the study arm. Conclusions: Continuous infusion 5-FU produced outcomes for local-regional control, DFS, and OS similar to those obtained with oral capecitabine combined with radiation. This study establishes capecitabine as a standard of care in the pre-operative rectal setting. Oxaliplatin did not improve the local-regional failure rate, DFS, or OS for any patient risk group but did add considerable toxicity. PMID:26374429

  19. 浅析脏腑理论与方剂配伍的关系%A brief Analysis on the Relationship between the Zang Fu Theory and Compatibility of Formula

    Institute of Scientific and Technical Information of China (English)

    齐放; 徐大鹏; 李明

    2013-01-01

    Each Zang-Fu organ has its own physiological characteristics .The relationships of inter-promotion and inter-restraint exist a-mong the Zang-Fu organs.Compatibility of formula can be modified according to physiological characteristics of the Zang and Fu organs and the relationships of inter-promotion and inter-restraint among the Zang and Fu organs .The Zang and Fu theory is an effective way to research the compatibility of formula and guide its clinical modification .%每个脏腑具有各自的生理特点,脏腑之间存在着相生相克的关系,方剂可以仿照脏腑的生理特点和脏腑之间生克制化的关系组方配伍。脏腑理论是研究方剂配伍和指导临证组方的有效途径。

  20. Effects of Shen-Fu Injection on the Expression of T-Cell-Specific Transcription Factors T-bet/Gata-3 in Porcine Postresuscitation Lung Injury

    Directory of Open Access Journals (Sweden)

    Wei Gu

    2013-01-01

    Full Text Available Shen-Fu injection (SFI derived from the ancient traditional Chinese medicine. In this study, the effects of SFI on the expression of T-bet/GATA-3 and its potential mechanisms causing the shift of T cells from Th2 to Th1 on postresuscitation lung injury were examined in a porcine model of cardiac arrest. 30 pigs were randomly divided into SHAM ( and three return of spontaneous circulation (ROSC groups ( per group; 24 pigs were subjected to 8 min of electrically induced cardiac arrest and 2 min of basic life support, which received central venous injection of Shen-Fu (SFI, epinephrine (EP or saline (SA. After successful ROSC, 18 surviving pigs were sacrificed at 24 h after ROSC ( per group. The levels of serum and lung tissue interleukin (IL-4 and interferon (IFN-γ were measured by ELISA, and the protein and mRNA levels of GATA-3 and T-bet in the lung tissue were determined by western blotting and quantitative real-time polymerase chain reaction, respectively. Compared with the EP and SA groups, SFI treatment reduced the levels of IL-4 (, increased levels of IFN-γ (, and induced T-bet mRNA upregulation and GATA-3 mRNA downregulation (. SFI attenuated lung injury and regulated lung immune disorders. Therefore, SFI could protect postresuscitation lung injury by modulating a Th1/Th2 imbalance.

  1. USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.

    Science.gov (United States)

    Zhang, Jing; Luo, Nan; Tian, Yu; Li, Jiazhi; Yang, Xiaozhou; Yin, Huimin; Xiao, Congshu; Sheng, Jie; Li, Yang; Tang, Bo; Li, Rongkuan

    2017-04-11

    USP22, a member of the deubiquitinases (DUBs) family, is known to be a key subunit of the human Spt-Ada-Gcn5 acetyltransferase (hSAGA) transcriptional cofactor complex. Within hSAGA, USP22 removes ubiquitin from histone proteins, thus regulating the transcription and expression of downstream genes. USP22 plays important roles in many cancers; however, its effect and the mechanism underlying HCC chemoresistance remain unclear. In the present study, we found that USP22 was highly expressed in chemoresistant HCC tissues and cells and was correlated with the prognosis of HCC patients who received chemotherapy. Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance-related proteins (MDR1, LRP, MRP1). Mechanistically, we found that USP22 knockdown exerts its function through down-regulating PI3K and activating Smad4, which inhibited phosphorylation of Akt. Silencing Smad4 blocked USP22 knockdown-induced Akt inhibition in Bel/Fu cells. Our results, for the first time, provide evidence that USP22 plays a critical role in the development of chemoresistant HCC cells and that high USP22 expression serves as a molecular marker for the prognosis of HCC patients who undergo chemotherapy.

  2. Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

    International Nuclear Information System (INIS)

    Ishikawa, Masashi; Miyauchi, Takayuki; Kashiwagi, Yutaka

    2008-01-01

    A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports have examined thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (DPD) in unresectable or metastatic cases, therefore it is unclear whether the activity of these enzymes is of prognostic value in colorectal cancer patients treated with radical resection and adjuvant chemotherapy with 5-FU. This study examined fresh frozen specimens of colorectal carcinoma from 40 patients who had undergone curative operation and were orally administered adjuvant tegafur/uracil (UFT) chemotherapy. TS, DPD and orotate phosphoribosyl transferase (OPRT) activities were assayed in cancer tissue and adjacent normal tissue and their association with clinicopathological variables was investigated. In addition, the relationships between TS, DPD and OPRT activities and patient survival were examined to determine whether any of these enzymes could be useful prognostic factors. While there was no clear relationship between pathological findings and TS or DPD activity, OPRT activity was significantly lower in tumors with lymph node metastasis than in tumors lacking lymph node metastasis. Postoperative survival was significantly better in the groups with low TS activity and/or high OPRT activity. TS and OPRT activity levels in tumor tissue may be important prognostic factors for survival in Dukes' B and C colorectal carcinoma with radical resection and adjuvant chemotherapy with UFT

  3. Prevalencia de asma y otras enfermedades alérgicas en niños escolares de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Barraza-Villarreal Albino

    2001-01-01

    Full Text Available Objetivo. Determinar la prevalencia y severidad del asma, de la rinitis y del eczema en escolares. Material y métodos. Estudio transversal efectuado entre abril de 1998 y mayo de 1999 en Ciudad Juárez, Chihuahua, México, a una muestra aleatoria de 6 174 niños de 53 escuelas. Se aplicó la metodología propuesta por el International Study of Asthma and Allergies in Childhood (ISAAC (etapas 1 y 2 para determinar la prevalencia y severidad del asma, rinitis y eczema. La información de prevalencia, tanto actual como acumulada para dichos padecimientos, se obtuvo mediante un cuestionario ya estandarizado y contestado por los padres de los niños. El diseño de la muestra se hizo por un muestreo mixto, en el cual se estratificó por nivel de contaminación ambiental. Se estimaron prevalencias actual y acumulada estratificando por grupo de edad, sexo, área e historia familiar de asma. Resultados. La prevalencia acumulada de asma por diagnóstico médico y sibilancia (silbidos fue de 6.8% (IC95% 6.2-7.4 y 20.% (IC95% 19.7-21.8, respectivamente; la prevalencia de sibilancia en los últimos 12 meses fue mayor en el grupo de 6-8 años que en el de 11-14 años(9.7% contra 5.8% (phttp://www.insp.mx/salud/index.html

  4. de la industria maquiladora para la exportación en Ciudad Juárez: una solución factorial

    Directory of Open Access Journals (Sweden)

    Andrés Hernández Gómez

    2015-01-01

    Full Text Available En este artículo se presentan los resultados de un estudio efectuado a personal rela - cionado con el proceso de implantación del Mantenimiento Productivo Total (MPT en empresas de la industria maquiladora de Ciudad Juárez, Chihuahua, México. Se aplicó un Análisis Factorial para identificar los Factores Críticos de Éxito (FCE vinculados con la implantación del MPT. El artículo inicia con la revisión del estado del arte que se llevó a cabo para la identificación de los FCE, los cuales están organizados en aspectos estratégi - cos y administrativos, del desarrollo del recurso humano y técnicos propios del MPT. Con esta información se construyó un instrumento para determinar los FCE en las plantas. La tercera sección describe la metodología, se valida el cuestionario y se justifica la aplicación de las pruebas estadísticas y el Análisis Factorial. La cuarta sección presenta los resultados, iniciando con la descripción del muestreo, conformado por 306 sujetos vinculados con la implantación del MPT. Se identificaron nueve factores críticos de éxito relacionados con la implantación efectiva del MPT, y se discuten sus efectos. Derechos Reservados©2015 Universidad Nacional Autónoma de México, Facultad de Contaduría y Administración. Este es un artículo de acceso abierto distribuido bajo los términos de la Licencia Creative Commons CC BY-NC-ND 4.0.

  5. Evaluación térmica del material ISOBLOCK en el clima cálido seco de ciudad. Juárez, México.

    Directory of Open Access Journals (Sweden)

    Luis Carlos Herrera Sosa

    2017-12-01

    Full Text Available Para que las viviendas mejoren su comportamiento térmico y disminuyan el consumo energético, producto del uso excesivo de sistemas de climatización convencional, las Normas de Eficiencia Energética de México establecen un factor de Resistencia Térmica (“R” mínima de acuerdo con cada región climática del país. Este documento presenta las conclusiones del trabajo de investigación térmica del material denominado Isoblock, que consiste en un block de concreto con aislamiento en su interior, que cumple satisfactoriamente con el factor “R” solicitado por la normativa. La investigación busca demostrar que es necesario que la normativa citada contemple la masa térmica de los materiales dentro de los parámetros térmicos a considerar. Desde ese enfoque, la metodología consistió en comparar el Isoblock con un block de concreto convencional en dos módulos de iguales características durante las temporadas climáticas extremas en Ciudad Juárez, Chihuahua. Por último, se simuló térmicamente con el software Design Builder V4.5 y se correlacionaron los resultados para su validación. A partir de dichos resultados se simuló el módulo de Isoblock con mayor cantidad de masa térmica sin variar su espesor, para medir su impacto en la temperatura interior. Los datos obtenidos demuestran que un material con un mismo factor “R” puede alcanzar temperaturas del aire interior más confortables, en temporadas extremas.

  6. La estructura urbana y las diferencias espaciales en el tiempo de traslado del viaje al trabajo en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    César M. Fuentes Flores

    2008-01-01

    Full Text Available Este artículo tiene como objetivo analizar las diferencias intraurbanas en los tiempos de traslado del viaje al trabajo en transporte público y privado, asociado a variables de uso del suelo (razón empleo/viviendas, densidad de población, valor del suelo, a características socioeconómicas (proporción de población con ingreso bajo y alto, y a la tenencia de la vivienda (proporción de viviendas propias y rentadas en Ciudad Juárez, Chihuahua. Las variables fueron construidas con información de la Encuesta de Origen-Destino 1997 (IMIP, el XII Censo de Ppoblación y Vivienda 2000 (INEEGI y el XIII Censo Económico 1999 (INEEGI a nivel de AGEB. El análisis se realizó mediante la construcción de cuatro modelos de regresión que se estimaron mediante la técnica de mínimos cuadrados ordinarios. Los resultados muestran que las variables razón empleo/viviendas, valor del suelo, y proporción de viviendas rentadas son estadísticamente significativas para explicar menores tiempos de traslado en transporte público. En contraste, la densidad de población y la proporción de viviendas propias son estadísticamente significativas para explicar menores tiempos de traslado en transporte público. La proporción de población de bajos ingresos es estadísticamente significativa para explicar los cambios en los tiempos de traslado en transporte privado.

  7. 78 FR 8105 - Steel Wire Garment Hangers From the Socialist Republic of Vietnam: Antidumping Duty Order

    Science.gov (United States)

    2013-02-05

    ... following companies: Acton Co., Ltd.; Angang Clothes Rack Manufacture Co.; Asmara Home Vietnam; B2B Co., Ltd...) CTN Limited Company CTN Limited Company 157.00 Ju Fu Co., Ltd Ju Fu Co., Ltd..... 157.00 Triloan.... \\6\\ The Vietnam-wide entity includes South East Asia Hamico Export Joint Stock Company, the TJ Group...

  8. Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    Zhou Kang; Li Xiaoguang; Jin Zhengyu; Yang Ning; Liu Wei; Pan Jie; Zhang Xiaobo; Shi Haifeng; Sun Hao; Wang Zhiwei

    2010-01-01

    Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the

  9. Fußball und Identität in Israel - Die Rolle der Medien im Kontext politisch-kultureller Identitätsbildung und Ausgrenzungsprozesse

    Directory of Open Access Journals (Sweden)

    Michael Schuster

    2010-03-01

    Full Text Available Eine gängige These besagt, dass sich im Sport gesellschaftliche Konflikte widerspiegeln. Insbesondere dem Fußball wird unterstellt, eine Arena zur Artikulation und Repräsentation exklusiver Identität nationaler Minderheiten zu bieten. Der vorliegende Artikel widmet sich dem Thema der politisch-kulturellen Identitätsbildung in fragmentierten Gesellschaften. Am Beispiel der arabischen Minderheit in Israel wird dargestellt, dass unter bestimmten gesellschaftlichen Konstellationen der Fußball als Element der Popularkultur dem Staat auch als Mittel der Unterdrückung eines nationalen Minderheitenbewusstseins dienen kann. Unter Zuhilfenahme der Hegemonietheorie Antonio Gramscis kann das Entstehen einer pro-israelischen Identität der arabischen Minderheit - in Abgrenzung zu einer eigenen, arabischen oder widerständigen Identität - im Kontext des Fußballs rekonstruiert werden. Zu diesem Zweck wird aufgezeigt, welche Bedeutungs- und Definitionsmacht hebräische und arabische Sportmedien als Akteure divergierender Bedeutungszuschreibungen in dem Konfliktfeld der Herausbildung politisch-kultureller Identitäten besitzen und ihrerseits vorherrschende Integrations- und Dominanzprozesse beeinflussen. It is a widespread/popular thesis that sports are a useful means to display social conflicts; in particular it is argued that football offers a platform for the articulation and representation of the identity of ethnic/national/(cultural minorities. This article focuses on the construction of identity in fragmented societies with the help of politics and culture. With the example of the Arab minority in Israel it is portrayed here, that under particular social circumstances football can be used as an element of popular culture to repress the cultural and political identity of minorities. Gramsci's theory of hegemony explains the construction of a pro-Israel identity among the Arab minority which differs from their own Arab identity. It is shown here to

  10. A randomised placebo-exercise controlled trial of Kung Fu training for improvements in body composition in overweight/obese adolescents: the "Martial Fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, M Fiatarone

    2009-01-01

    The purpose of the study was to investigate if Chinese martial arts (Kung Fu, KF) might be effective for improving body composition, as well as being an appealing form of physical activity for inexperienced, sedentary, overweight/obese adolescents. Twenty subjects (age: 13.3 ± 1.8 y; BMI percentile: 98.6(86.5 - 99.8); 60% girls) were randomly-assigned to the supervised KF or placebo (Tai Chi, TC) control group 3 d.wk(-1) for 6 months. We assessed body composition, including total and regional fat and lean mass, total and regional bone mineral density (BMD), percent lean and fat mass, body mass index and waist circumference, at baseline and after 6 months of training using anthropometry and dual-energy X-ray absorptiometry (DXA). Habitual physical activity and dietary intake were recorded as covariates via self-report at each time-point. As expected due to natural growth, significant increases in height, weight, total and lumbar BMD, and lean mass were seen in the cohort over time, with a trend for increased whole body fat mass, with no difference between groups. By contrast, percent fat and android fat mass via DXA did not increase in either group over time. The absence of a similar expected increase in central adiposity over 6 months could indicate a positive effect of participation in both programs on the metabolically critical abdominal adiposity in this cohort. Further research in this area is warranted to determine ways to increase uptake and compliance, and to see if longer-term martial arts training not only maintains, but improves abdominal fat mass and related metabolic health indices in overweight/ obese adolescents. Key pointsParticipation in our martial arts trial attenuated the increases in body fat mass expected due to growth in our overweight/obese adolescent group.All subjects allocated to the Kung Fu intervention were satisfied with their Kung Fu training, in contrast to our placebo-exercise (Tai Chi) subjects, suggesting that this form of

  11. Desarrollo de un destino de turismo médico en el contexto de la frontera México-Estados Unidos: el caso de Ciudad Juárez, Chihuahua, México

    OpenAIRE

    Martínez Almanza, María Teresa

    2016-01-01

    La asistencia sanitaria es uno de los temas primordiales del siglo XXI. Los problemas relacionados con la atención médica contemporánea han generado una creciente demanda de servicios de pacientes extranjeros. En el marco de la teoría fundamentada, mediante 69 entrevistas en profundidad, realizadas de 2013 a 2015, se analiza el proceso de desarrollo de Ciudad Juárez, Chihuahua, México como un destino turístico médico de frontera. Se presenta una narrativa de la génesis y evolución del caso d...

  12. Preliminary results of pre-operative 5-FU, low dose leucovorin (LV), and concurrent radiation therapy (RT) for resectable T3 rectal cancer

    International Nuclear Information System (INIS)

    Grann, Alison; Minsky, Bruce D.; Cohen, Alfred M.; Saltz, Leonard; Kelsen, David P.; Kemeny, Nancy; Ilson, David; Guillem, Jose G.; Paty, Philip B.; Bass, Joanne

    1996-01-01

    PURPOSE: We report the downstaging, acute toxicity, and preliminary local control and survival of pre-op 5-FU, low dose LV, and concurrent RT followed by post-op LV/5-FU for pts with clinically resectable, T3 rectal cancer. MATERIALS AND METHODS: A total of 32 pts (M:26, F:6) were prospectively treated from 12/91-8/95. Eligibility criteria included adequate hematologic indicies, primary adenocarcinoma limited to the pelvis, and T3 disease confirmed by transrectal ultrasound. Twenty five pts were considered clinically to require an APR on initial (pre-treatment) assessment by their operating surgeon. The median age was 56 (range: 24-80), and the median distance from the anal verge was 5.0cm (range: 3-9cm). Pts received 2 monthly cycles (bolus daily X 5) of LV (20mg/m2) and 5-FU (325mg/m2), beginning concurrently with day 1 of RT, followed by surgery 4-5 weeks later. RT included 4680 cGy to the pelvis followed by a boost to 5040 cGy. Post-operatively, pts received a median of 2 monthly cycles (range: 0-10 cycles) of LV (20 mg/m2) and 5-FU (425mg/m2). A toxicity assessment was performed at each visit using the NCI toxicity criteria modified for gastrointestinal toxicity. The median follow-up was 12 months (range: 3-48 months). All 32 patients were included in the analysis of toxicity, sphincter preservation, and downstaging. Analysis of patterns of failure and survival was limited to the 15 pts who had a minimum follow-up of 1yr or developed failure prior to 1 yr. For this subset the median follow-up was 24 months (range: 3-48 months). RESULTS: During the pre-op segment, individual grade 3+ acute toxicities were; diarrhea: 16%, bowel movements: 16%, leukopenia: 12%. The incidence of total toxicity was 25% ((8(32))). The median nadir counts were; WBC: 2.9 (range: 1.7-5.6), HGB: 12.4 (range: 7.1-15.0), and PLT (X1000): 161 (range: 113-237). The pathologic complete response rate was 9% ((3(32))). An additional 13% ((4(32))) had negative lymph nodes and 1-2 microscopic

  13. Molecular analysis of Ixodes rugicollis, Candidatus Neoehrlichia sp. (FU98) and a novel Babesia genotype from a European badger (Meles meles).

    Science.gov (United States)

    Hornok, Sándor; Trauttwein, Klaudia; Takács, Nóra; Hodžić, Adnan; Duscher, Georg Gerhard; Kontschán, Jenő

    2017-01-01

    The European badger (Meles meles) is a widespread mammal in most countries of the European continent, with increasingly recognized veterinary/medical importance owing to its preferred habitats (including pastures and urban environments), broad spectrum of food items, and role as a game hunting target. However, ticks and tick-borne pathogens associated with badgers are only partly known, and most of them have not yet been analysed with molecular biological methods The aim of this study was to perform molecular taxonomic analysis of ticks collected from a road-killed European badger, as well as to molecularly investigate its ticks and blood sample for the presence of Anaplasmataceae and piroplasms. Ticks from the badger were morphologically identified as females of Ixodes rugicollis. Based on its cytochrome oxidase subunit I (COI) and 16S rRNA sequences, I. rugicollis phylogenetically clustered together with I. lividus and I. arboricola, i.e. other members of the subgenus Pholeoixodes. The blood sample of the badger contained the DNA of Candidatus Neoehrlichia sp. (FU98) recently identified in red fox in Austria and the Czech Republic. This genotype is most closely related to Ca. N. lotoris (from raccoons in North America), and has lower sequence identity with the I. ricinus-transmitted zoonotic agent, Ca. N. mikurensis found in Eurasia. In the blood of the badger and in one female I. rugicollis, the DNA of a new Babesia genotype was also present, which differed from a piroplasm detected in M. meles in Spain, and clustered phylogenetically in the B. microti clade. Phylogenetic analysis of I. rugicollis (based on two genetic markers) confirms its status in subgenus Pholeoixodes. Ca. Neoehrlichia sp. (FU98) was identified for the first time in M. meles and in Hungary. In addition, a molecularly previously not yet characterized Babesia genotype occurs in badgers in Central Europe. Copyright © 2016 Elsevier GmbH. All rights reserved.

  14. O "Kung Fu" no Brasil na perspectiva dos mestres pioneiros: problemas e perspectivas no uso da história oral como instrumental de análise

    Directory of Open Access Journals (Sweden)

    Fernando Dandoro Castilho FERREIRA

    2014-03-01

    Full Text Available Objetivando analisar a disseminação das artes marciais chinesas no Brasil optamos por entrevistar mestres pioneiros que imigraram da China trazendo na bagagem o "Kung Fu". Ao fazer esta opção em nossa dissertação, tomamos contato com um instrumental que é o uso de entrevistas na perspectiva da História Oral. Remexer a memória, aceitar os silêncios, respeitar o conhecimento construído e desconstruir outros, por si só já se mostram tarefas bastante árduas. Escutar estes mestres nos levou, mesmo que superficialmente, a tentar compreender aspectos da cultura chinesa sob os quais os mestres e o próprio "Kung Fu" se fundamentaram. Entender as lacunas, as dificuldades e as possibilidades do uso da História Oral como ferramenta metodológica é o que neste artigo buscamos, na perspectiva de contribuir com análises semelhantes, seja de outras práticas marciais ou mesmo de outros olhares sobre a cultura chinesa. Assim sendo, objetivamos neste artigo apontar e discutir a metodologia da História Oral e sua pertinência para o estudo das práticas marciais a partir do uso de entrevistas. Podemos, fruto da discussão apresentada, apontar a História Oral como instrumental bastante útil para a discussão das práticas marciais, considerando logicamente, as pertinências e especificidades necessárias para a adequada utilização desta metodologia de pesquisa.

  15. Magnetism of Minor Bodies in the Solar System: From 433 Eros, passing Braille, Steins, and Lutetia towards Churyumov-Gerasimenko and 1999 JU3.

    Science.gov (United States)

    Hercik, David; Auster, Hans-Ulrich; Heinisch, Philip; Richter, Ingo; Glassmeier, Karl-Heinz

    2015-04-01

    observations the next ideal candidate mission is Hayabusa-II with its Mascot lander equipped with fluxgate magnetometer. The small-sized lander shall deliver the magnetometer within centimeters from the surface, providing measurements on multiple points thanks to a hopping ability. The mission has been recently launched (December 2014) and is aiming to a C-type asteroid 1999 JU3 to reach it in 2018. The results will hopefully add some piece of information to the still unclear question of minor solar system bodies magnetization.

  16. Un programa de fertilización sustentable para el Ingenio "Presidente Benito Juárez" en Tabasco, México

    Directory of Open Access Journals (Sweden)

    S. Salgado-García

    2011-01-01

    Full Text Available Las dosis de fertilización y sitio específicos para el cultivo de caña de azúcar en el área de abastecimiento del Ingenio "Presidente Benito Juárez" (Ipbj no habían sido precisados, sin embargo, el alto costo de los fertilizantes químicos y la necesidad de reducir la contaminación del ambiente obligan a optimizar su uso. A fin de precisar dosis de fertilización adecuadas para dicha área, este trabajo emplea la metodología del "Sistema Integrado para Recomendar Dosis de Fertilizantes", tomando en cuenta las características de los suelos y el rendimiento potencial. Como parte de este estudio, se identificaron las subunidades de suelo mediante interpretación de fotografías aéreas, reconocimientos de campo y muestreos (-1.20 m en el área de influencia del Ipbj (92,973 ha. En cada unidad se describieron perfiles agrológicos y se hicieron análisis físico-químicos para clasificar los suelos, según el Referencial Mundial de Suelos (wrb. Los resultados generaron cinco polígonos de Thiessen, con precipitaciones anuales entre 1,640 a 2,227 mm. Se determinó una dosis de fertilización npk para cada subunidad de suelo, usando el modelo conceptual de balance entre demanda del nutrimento, el suministro y la eficiencia del fertilizante aplicado. Las dosis de fertilización ajustadas son (N, P2O5, K2O kg/ha, 120-60-60 para los suelos Cambisolesflúvicos, endogléyicos y estágnicos, 120-70-80 para Cambisoles y Gleysoles; 160-80-80 para Vertisoles gléyico-estágnicos, 120-80-80 para Vertisoles estágnico-éutricos. Además, se generó un mapa de fertilización específico para el área de abasto del Ipbj, a escala 1:40 000.

  17. [Review of the CD Betel Nuts by Christopher Roberts (1996)

    OpenAIRE

    Senft, G.

    2001-01-01

    (TMCD 9602). Taipei: Trees Music & Art, 12-1, Lane 10, Sec. 2, Hsin Yi Rd. Taipei, TAIWAN. Distributed by Sony Music Entertainment (Taiwan)Ltd.,6th fl. No 35 , Lane 11, Kwang-Fu N. Rd., Taipei TAIWAN (CD accompanied by a full color bucklet)

  18. AL SAHLI, AA; OKOLI, JU

    African Journals Online (AJOL)

    ADOWIE PERE

    area (the control site) showed a high degree of similarity, suggesting that pollen assemblages of ... Standard methods were used for the collection and analysis of soil .... environmental restoration activities (Adekanmbi, .... The refugia forest.

  19. RESONANCE--I-Ju-ne

    Indian Academy of Sciences (India)

    I read the above article in the Classroom Section of the March 2006 issue of Resonance with great interest, but was disappointed at the end. The problem investigated is an ... In our article, we have shown that the approach in solving of this problem is not correct. In a typical RC circuit, value of inductance is taken as zero, ...

  20. RESONANCE----I--Ju-ne

    Indian Academy of Sciences (India)

    work there emerged the concepts of functionality ... Copyright 19S0 American Chemi- ... hired by DuPont, and assigned to work in Carothers' group. .... In the Flory model, the application of stress, e.g., ... research institute, and academic activity.

  1. A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy

    International Nuclear Information System (INIS)

    Lim, L; Gibbs, P; Yip, D; Shapiro, JD; Dowling, R; Smith, D; Little, A; Bailey, W; Liechtenstein, M

    2005-01-01

    To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. Patients were prospectively enrolled at three Australian centres. All patients had previously received 5-FU based chemotherapy for metastatic colorectal cancer. Patients were ECOG 0–2 and had liver dominant or liver only disease. Concurrent 5-FU was given at investigator discretion. Thirty patients were treated between January 2002 and March 2004. As of July 2004 the median follow-up is 18.3 months. Median patient age was 61.7 years (range 36 – 77). Twenty-nine patients are evaluable for toxicity and response. There were 10 partial responses (33%), with the median duration of response being 8.3 months (range 2–18) and median time to progression of 5.3 mths. Response rates were lower (21%) and progression free survival shorter (3.9 mths) in patients that had received all standard chemotherapy options (n = 14). No responses were seen in patients with a poor performance status (n = 3) or extrahepatic disease (n = 6). Overall treatment related toxicity was acceptable, however significant late toxicity included 4 cases of gastric ulceration. In patients with metastatic colorectal cancer that have previously received treatment with 5-FU based chemotherapy, treatment with SIR-spheres has demonstrated encouraging activity. Further studies are required to better define the subsets of patients most likely to respond

  2. Efeitos da pasteurização sobre características físico-químicas, microbiológicas e teor de antocianinas da polpa de juçaí (Euterpe edulis Martius

    Directory of Open Access Journals (Sweden)

    Érica Cristina Marins Barros

    2015-07-01

    Full Text Available A Juçara (Euterpe edulis Mart., é uma palmeira nativa do bioma da Mata Atlântica, sendo encontrada do Rio Grande do Sul até o sul da Bahia. Visando melhorar a conservação dos alimentos em diversos processos são utilizados métodos físicos e químicos de conservação. Este trabalho teve como objetivo o estudo dos efeitos do processamento térmico sobre a polpa de juçaí. O produto foi submetido ao processo de pasteurização em três diferentes temperaturas (72ºC, 80ºC e 88ºC durante 60 segundos. Foram realizadas análises físico-químicas, microbiológicas e determinação de antocianinas com o intuito de avaliar a influência do tratamento térmico nas propriedades e qualidade da polpa.

  3. The Use of Thermal Analysis and Photoacoustic Spectroscopy in the Evaluation of Maltodextrin Microencapsulation of Anthocyanins from Juçara Palm Fruit (Euterpe edulis Mart. and Their Application in Food

    Directory of Open Access Journals (Sweden)

    Ana Paula da Silva dos Passos

    2015-01-01

    Full Text Available Anthocyanins extracted from the pulp of the fruit of juçara palm (Euterpe edulis Mart. were microencapsulated with maltodextrin in order to stabilise them. Photoacoustic spectroscopy was used to investigate the photostability of the microencapsulated samples. Complementary differential scanning calorimetry and scanning electron microscopy measurements were also performed. Lyophilised extract had 14 340.2 mg/L of total anthocyanins, and the microencapsulation effi ciency of 93.6 %. Temperature analysis showed that maltodextrin conferred protection up to 70 °C for 120 min. Scanning electron microscopy showed that the microencapsulated particles had a flake-like morphology with a smooth surface, characteristic of lyophilisation processes. In addition, when added to yogurt, a red colourant was predominant in the samples at pH from 1.5 up to 5.0. Thermal analysis showed a weak interaction between the sample and the encapsulating agent, and photoacoustic data indicated the photostability of the matrix when exposed to light. Yogurts containing microencapsulated anthocyanins showed a more intense pink colour than yogurts treated with pure dye, and sensory analysis demonstrated that they can have good acceptance on the market. Microencapsulation enabled the innovative application of anthocyanins from juçara palm fruit, and complementary techniques allied to the photoacoustic spectroscopy were effective tools for its evaluation.

  4. Galveno veiktspējas rādītāju izmantošana uzņēmuma stratēģisko mērķu sasniegšanai

    OpenAIRE

    Milčs, Olafs

    2015-01-01

    Bakalaura darbu „Galveno veiktspējas rādītāju izmantošana stratēģisko mērķu sasniegšanai” izstrādājis Olafs Milčs. Darba autors novērtējis SIA „Latvia Tours” darbības aspektus, kas ir kritiski uzņēmuma nākotnes attīstībai, veicis uzņēmuma apgrozījumu veidojošo aspektu analīzi un identificējis galvenos veiktspējas rādītājus, kas uzņēmuma vadībai ļaus uzraudzīt uzņēmuma stratēģijā 2014.-2019. gadam iekļauto stratēģisko mērķu progresu. Sasniedzot autora identificētos galveno veiktspējas rādītāju...

  5. Latvijas kā medicīnas tūrisma galamērķa konkurētspēju ietekmējošie faktori

    OpenAIRE

    Sidorenko, Anna

    2012-01-01

    Bakalaura darba temats ir «Latvijas kā medicīnas tūrisma galamērķa konkurētspēju ietekmējošie faktori». Ņemot vērā starptautisko pieredzi, medicīnas pakalpojumu sniegšana ārvalstniekiem var nodrošināt papildus ienākumu avotu nacionālajai ekonomikai. Bakalaura darba mērķis ir identificēt un izpētīt faktorus, kas ietekmē Latvijas kā medicīnas tūrisma galamērķa konkurētspēju un izstrādāt priekšlikumus medicīnas pakalpojumu sniedzējiem un valsts pārvaldes institūcijām ar nolūku veicināt Latvij...

  6. Tiešsaistes videospēļu “Counter Strike” un “League of Legends” spēlētāju interaktīvā komunikācija

    OpenAIRE

    Kaminskis, Dāvis

    2017-01-01

    Bakalaura darbā „tiešsaistes video spēļu „Counter Strike” un „League of Legends” spēlētāju interaktīvā komunikācija” tiek pētīta verbālās un neverbālās valodas lietošana un tās pielietojums dažādos komunikācijas kanālos. Papildus pēc iegūtajiem datiem un veiktajiem novērojumiem tiek noskaidrots auditorijas (spēlētāju) viedoklis par komunikācijas saturu un nepieciešamību. Darba teorētisko daļu veido daļas par kvalitatīvu komunikāciju, kā arī nodaļas par interaktīvo komunikāciju, tiešsaist...

  7. Zīmola nozīme patērētāju lēmuma pieņemšanā mēbeļu mazumtirdzniecībā.

    OpenAIRE

    Pētersons, Miks

    2013-01-01

    Maģistra darba temats ir „Zīmola nozīme patērētāju lēmuma pieņemšanā mēbeļu mazumtirdzniecībā”. Darba mērķis ir teorētiski analizēt un praktiski noskaidrot zīmola nozīmi patērētāja lēmuma pieņemšanā par mēbeļu iegādi. Temats ir aktuāls un darbā apkopotie rezultāti var būt saistoši Latvijas mēbeļu nozares dalībniekiem. 1. nodaļā autors izvērtē patērētāju uzvedību noteicošos faktorus, kā arī zīmola nozīme lēmuma pieņemšanā. 2. nodaļā analizēta mēbeļu ražošanas nozare Latvijā, veikta uzņēm...

  8. Difference in effect of single immunosuppressive agents (cyclophosphamide, CCNU, 5-FU) on peripheral blood immune cell parameters and central nervous system immunoglobulin synthesis rate in patients with multiple sclerosis.

    Science.gov (United States)

    Shih, W W; Baumhefner, R W; Tourtellotte, W W; Haskell, C M; Korn, E L; Fahey, J L

    1983-01-01

    Cyclophosphamide (CY), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-fluorouracil (5-FU) were given in single course schedules to chronic progressive multiple sclerosis (MS) patients clinically stable for 6 months. The following peripheral immune cellular parameters were measured before, during and after each drug administration: white blood count (WBC), polymorphonuclear count (PMN), lymphocyte count, percentage of T cells, T cell response to phytohaemagglutinin (PHA), percentage of B cells, percentage of cells bearing receptors for the Fc portion of immunoglobulin (% FcR cells), killer (K) cell activity defined by antibody-dependent cellular cytotoxicity (ADCC), and natural killer (NK) cell activity. Central nervous system (CNS) immunoglobulin G (IgG) synthesis was also measured. The patients were followed carefully by both quantitative and qualitative methods for any change in their neurologic condition. Selective reduction in NK activity was observed with CY and 5-FU while no significant alteration was seen in %FcR cells and K activity. CY differed from 5-FU in reducing lymphocyte count and B cell percentage while 5-FU decreased the percentage of T cells. CCNU, but not the other drugs, reduced T cell proliferative response to PHA. In addition, CCNU, which is known to penetrate well into the nervous system, caused a modest reduction in CNS IgG synthesis, while 5-FU had an uncertain effect. Clinically the patients were unchanged or continued to progress in their disability. The results suggest an independence of the CNS immune from the systemic immune system in MS in response to many immunosuppressive drugs. PMID:6603303

  9. ¿La práctica de la siembra directa en cultivos de soja favorece las poblaciones de acridios (Orthoptera: Acrididae en el partido de Benito Juárez? Does the direct tillage practice in soybean crops favour grasshopper populations (Orthoptera: Acrididae, in Benito Juárez county?

    Directory of Open Access Journals (Sweden)

    Daniel Scuffi

    2012-12-01

    Full Text Available Considerando el desarrollo del cultivo de soja en siembra directa en el partido de Benito Juárez, y que algunos autores sostienen que esta práctica favorece los acridios, se evaluó la riqueza de especies y la abundancia en soja con siembra directa y convencional. Se registraron siete especies (Aleuas lineatus Stål, Covasacris pallidinota (Bruner, Baeacris pseudopunctulatus (Ronderos, Dichroplus elongatus Giglio-Tos, Dichroplus maculipennis (Blanchard, Dichroplus pratensis Bruner y Scotussa lemniscata (Stål. La riqueza de especies acumulada en los diferentes cultivos fue similar (p> 0,05. En soja de primera con siembra directa, se registraron 2,3 ± 0,19 especies, en soja de primera con siembra convencional 1,45 ± 0,15 especies y en soja de segunda con siembra directa 2,25 ± 0,28 especies. Dichroplus elongatus fue la especie más abundante en todos los cultivos y en todos los momentos. Las restantes presentaron baja abundancia y se registraron en algunos momentos. No existió diferencia (p> 0,05 en la abundancia de tucuras entre los cultivos y en las diferentes fechas de muestreo. La baja riqueza de especies registrada estaría relacionada con la baja diversidad vegetal de los cultivos. Este estudio no mostró diferencias en la abundancia y riqueza de especies de acuerdo a la labranza utilizada.Considering the development of the soybean crops using direct tillage in Benito Juárez county, and taking into account that for some authors this practice favours the grasshopper populations, the abundance and species richness in soybean with direct and conventional tillage were evaluated. Seven species were registered (Aleuas lineatus Stål, Covasacris pallidinota (Bruner, Baeacris pseudopunctulatus (Ronderos, Dichroplus elongatus Giglio-Tos, Dichroplus maculipennis (Blanchard, Dichroplus pratensis Bruner and Scotussa lemniscata (Stål. The accumulated richness was similar (p> 0.05, along the different crops; 2.3 ± 0.19 species were registered in

  10. Disponibilidad de esporomas de hongos comestibles en los bosques de pino-encino de Ixtlán de Juárez, Oaxaca Edible mushroom sporocarp availability in pine-oak forests in Ixtlán de Juárez, Oaxaca

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    Roberto Garibay-Orijel

    2009-08-01

    Full Text Available Los hongos comestibles son recursos forestales cuyo aprovechamiento sustentable depende del conocimiento de la distribución y productividad de sus esporomas. En el presente trabajo se evaluó la disponibilidad de 81 hongos comestibles por medio de la abundancia, distribución temporal y espacial de sus esporomas. Estas variables se integraron en un índice de importancia ecológica (VI que brinda una medida para estimar la disponibilidad de sus esporomas en los bosques. El estudio se realizó durante 2001 y 2002 en los bosques de Pinus-Quercus de Ixtlán de Juárez, Oaxaca. Las especies más abundantes fueron Laccaria laccata var. pallidifolia, Gymnopus confluens y Laccaria vinaceobrunnea. La especie con mayor producción de biomasa húmeda de esporomas (2.21 Kg/sitio de muestreo fue Laccaria laccata var. Pallidifolia. Sólo G. confluens y G. dryophilus produjeron esporomas desde principios de junio hasta finales de octubre. Las especies con mayor disponibilidad fueron L. laccata var. pallidifolia, G. confluens, L. vinaceobrunnea y H. purpurascens. La riqueza de hongos comestibles silvestres en Ixtlán es alta (96 especies, pero su disponibilidad es muy heterogénea (de L. laccata var. pallidifolia VI = 0.7905, a Helvella infula VI = 0.0055. Dentro del mismo bosque, en sitios relativamente cercanos la composición de especies es diferente y su producción de esporomas y biomasa son contrastantes.Wild edible mushrooms are non timber forest products whose sustainable use must have an ecological basis. In this work, we measured the availability of 81 edible mushrooms by means of their abundance, frequency, biomass production, temporal and spatial distribution of their fruiting bodies. These variables were integrated into an ecological importance index (IV which describes sporome availability in the forest. The research was carried out during 2001 and 2002 in the Pinus-Quercus forests of Ixtlán de Juárez, Oaxaca. The most abundant species were

  11. Identificación de asentamientos irregulares y diagnóstico de sus necesidades de infraestructura en Ciudad Juárez, Chihuahua, México

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    Ivan Elias Ruiz Hernandez

    2015-01-01

    ón remota, análisis espacial e información censal. Los atributos físicos incluyen las condiciones del terreno, disección vertical y zonas de riesgo geológico y de inundación. Los atributos socioeconómicos incluyen, polígonos de pobreza, cobertura de agua potable y drenaje, nivel de hacinamiento, relación centro-periferia y valor del suelo. Los atributos de organización espacial y tipo de materiales de construcción, fueron recabados de imágenes satelitales de alta resolución y métricas de paisaje. Estos tres grupos de variables fueron integrados en un modelo multicriterio para la identificación de AI en Ciudad Juárez, Chihuahua, México. El modelo permite no solo la identificación de dichos AI sino también la realización de un diagnóstico de sus necesidades de infraestructura y servicios urbanos contando con un nivel de exactitud del 97.66%. Esta investigación presenta un método nuevo y confiable para la identificación de AI y a su vez los resultados obtenidos proveen una importante herramienta para los responsables del desarrollo urbano en la toma de decisiones.

  12. Polpa de juçara: fonte de compostos fenólicos, aumento da atividade antioxidante e da viabilidade de bactérias probióticas de iogurte

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    Sabrina Torres Leite

    Full Text Available RESUMO A adição, em iogurtes, de polpa de Juçara como fonte de compostos fenólicos pode modificar as características físico-químicas, contribuir para atividade antioxidante, e interferir na viabilidade de bactérias probióticas e na aceitação sensorial. Com o objetivo de verificar o efeito da adição de polpa de Juçara em iogurte, foi realizado um experimento, em delineamento inteiramente casualizado, em parcelas subdivididas. A parcela principal foi o teor de polpa, com seis níveis (0, 5, 10, 15, 20 e 25% e, como subparcela, o tempo de armazenamento, a 5 oC, com cinco níveis (1, 7, 14, 21 e 28 dias. Os teores percentuais médios de gordura, cinzas, extrato seco total e acidez dos iogurtes não diferiram (P ≥ 0,05. O teor de proteína diminuiu com o aumento do teor de polpa, variando de 4,07% (F0 a 2,9% (F25%. O conteúdo fenólico total e a atividade antioxidante foram maiores no iogurte com 25% de polpa, atingindo valores de 117,84 mg de AGE/100g e 6,95 µmol Trolox/g, respectivamente, assim como a contagem de bactérias probióticas, que variou de 3,17 log UFC.g-1 (F0 a 6,34 log UFC.g-1 (F25%, nos iogurtes, após 28 dias de armazenamento. A adição da polpa de Juçara favoreceu a multiplicação e a viabilidade de bactérias probióticas, contribuiu para o aumento do conteúdo fenólico total e para maior atividade antioxidante dos iogurtes, que apresentaram boa aceitação sensorial pelo consumidor.

  13. The ReFuGe 2020 consortium - Using ‘omics’ approaches to explore the adaptability and resilience of coral holobionts to environmental change

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    Christian Robert Voolstra

    2015-09-01

    Full Text Available Human-induced environmental changes have been linked directly with loss of biodiversity. Coral reefs, which have been severely impacted by anthropogenic activities over the last few decades, exemplify this global problem and provide an opportunity to develop research addressing key knowledge gaps through ‘omics’-based approaches. While many stressors, e.g. global warming, ocean acidification, overfishing and coastal development have been identified, there is an urgent need to understand how corals function at a basic level in order to conceive strategies for mitigating future reef loss. In this regard, availability of fully sequenced genomes has been immensely valuable in providing answers to questions of organismal biology. Given that corals are metaorganisms comprised of the coral animal host, its intracellular photosynthetic algae, and associated microbiota (i.e. bacteria, archaea, fungi, viruses, these efforts must focus on entire coral holobionts. The Reef Future Genomics 2020 (ReFuGe 2020 consortium has formed to sequence hologenomes of ten coral species representing different physiological or functional groups to provide foundation data for coral reef adaptation research that is freely available to the research community.

  14. Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San on High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats

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    Bailu Duan

    2017-01-01

    Full Text Available The aim of this study was to investigate the antidiabetic effects of a Tibetan medicine, Tang-Kang-Fu-San (TKFS, on experimental type 2 diabetes mellitus (T2DM rats and to explore its underlying mechanisms. Firstly two major chemical compositions of TKFS, gallic acid and curcumin, were characterized by HPLC fingerprint analysis. Next T2DM in rats was induced by high-fat diet and a low-dose streptozotocin (STZ 35 mg/kg. Then oral gavage administration of three different doses of TKFS (0.3 g/kg, 0.6 g/kg, and 1.2 g/kg was given to T2DM rats. Experimental results showed that TKFS dramatically reduced the levels of fasting blood glucose, fasting blood insulin, triglyceride, total cholesterol, LDL cholesterol, and HDL cholesterol, even though it did not alter the animal body weight. The downregulation of phosphorylation-AKT (p-AKT and glucose transporter-4 (GLUT4 in skeletal muscle of T2DM rats was restored and abnormal pathological changes in pancreas tissues were also improved. Our work showed that TKFS could alleviate diabetic syndromes, maintain the glucose homeostasis, and protect against insulin resistance in T2DM rats, and the improvement of AKT phosphorylation and GLUT4 translocation in skeletal muscle would be one of its possible underlying mechanisms.

  15. Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells

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    Hong-Quan Duong

    2017-07-01

    Full Text Available Pancreatic cancer remains an intractable cancer with a poor five-year survival rate, which requires new therapeutic modalities based on the biology of pancreatic oncogenesis. Nuclear factor E2 related factor-2 (NRF2, a key cytoprotective nuclear transcription factor, regulates antioxidant production, reduction, detoxification and drug efflux proteins. It also plays an essential role in cell homeostasis, cell proliferation and resistance to chemotherapy. We aimed to evaluate the possibility that modulation of NRF2 expression could be effective in the treatment of pancreatic cancer cells. We investigated whether the depletion of NRF2 by using small interfering RNAs (siRNAs is effective in the expression of biomarkers of pancreatic cancer stemness such as aldehyde dehydrogenase 1 family, member A1 (ALDH1A1 and aldehyde dehydrogenase 3 family, member A1 (ALDH3A1. NRF2 knockdown markedly reduced the expression of NRF2 and glutamate-cysteine ligase catalytic subunit (GCLC in cell lines established from pancreatic cancers. NRF2 silencing also decreased the ALDH1A1 and ALDH3A1 expression. Furthermore, this NRF2 depletion enhanced the antiproliferative effects of the chemotherapeutic agent, 5-fluorouracil (5-FU in pancreatic cancer cells.

  16. On-line monitoring the extract process of Fu-fang Shuanghua oral solution using near infrared spectroscopy and different PLS algorithms

    Science.gov (United States)

    Kang, Qian; Ru, Qingguo; Liu, Yan; Xu, Lingyan; Liu, Jia; Wang, Yifei; Zhang, Yewen; Li, Hui; Zhang, Qing; Wu, Qing

    2016-01-01

    An on-line near infrared (NIR) spectroscopy monitoring method with an appropriate multivariate calibration method was developed for the extraction process of Fu-fang Shuanghua oral solution (FSOS). On-line NIR spectra were collected through two fiber optic probes, which were designed to transmit NIR radiation by a 2 mm flange. Partial least squares (PLS), interval PLS (iPLS) and synergy interval PLS (siPLS) algorithms were used comparatively for building the calibration regression models. During the extraction process, the feasibility of NIR spectroscopy was employed to determine the concentrations of chlorogenic acid (CA) content, total phenolic acids contents (TPC), total flavonoids contents (TFC) and soluble solid contents (SSC). High performance liquid chromatography (HPLC), ultraviolet spectrophotometric method (UV) and loss on drying methods were employed as reference methods. Experiment results showed that the performance of siPLS model is the best compared with PLS and iPLS. The calibration models for AC, TPC, TFC and SSC had high values of determination coefficients of (R2) (0.9948, 0.9992, 0.9950 and 0.9832) and low root mean square error of cross validation (RMSECV) (0.0113, 0.0341, 0.1787 and 1.2158), which indicate a good correlation between reference values and NIR predicted values. The overall results show that the on line detection method could be feasible in real application and would be of great value for monitoring the mixed decoction process of FSOS and other Chinese patent medicines.

  17. Evaluation of hematologic toxicity of concurrent chemoradiotherapy using protracted infusion of low-dose cisplatin and 5-FU and radiotherapy for malignant tumors in elderly patients

    International Nuclear Information System (INIS)

    Itoh, Yoshiyuki; Fuwa, Nobukazu; Matsumoto, Akira; Asano, Akiko; Sasaoka, Masahiro; Ii, Noriko; Kimura, Yasuo

    1999-01-01

    We evaluated the relationship between hematologic toxicity and the daily dose of CDDP or the field size of radiation in 26 patients with malignant tumors aged>70 years who underwent concurrent chemoradiotherapy consisting of infusion of low-dose CDDP and 5-FU and radiotherapy. None of the 26 patients developed Gr4 toxicity. The incidence of Gr3 toxicity was 23.1% (6/26) for leukocytes, 7.7% (2/26) for platelets, and 3.8% (1/26) for hemoglobin, being high for leukocytes. When the patients were classified into those aged 70-74 years (younger group) and those aged>75 years (older group), the incidence of Gr3 leukocyte and platelet toxicity was low in the former but high in the latter. Concerning the relationship between hematologic toxicity and the field size of radiation, the incidence of Gr3 hemoglobin, leukocyte, and platelet toxicity with a radiation field size 2 was 44% (4/9) in the older group but 0% in the younger group. In the older group, the daily CDDP dose tended to be low, and the field size of radiation tended to be small, but the incidence of hematological toxicity was high. In the younger group, the incidence of Gr2 or Gr3 toxicity increased with the daily dose of CDDP and the field size of radiation. (author)

  18. Impact of Martial Arts (Judo, Karate, and Kung Fu) on Bone Mineral Density Gains in Adolescents of Both Genders: 9-Month Follow-Up.

    Science.gov (United States)

    Ito, Igor H; Kemper, Han C G; Agostinete, Ricardo R; Lynch, Kyle R; Christofaro, Diego G D; Ronque, Enio R; Fernandes, Rômulo A

    2017-11-01

    To compare bone mineral density (BMD) gains in adolescents of both genders stratified according to different martial art styles in a 9-month follow-up study. The longitudinal study consisted of 29 adolescents of both genders and age between 11 and 17 years stratified into a control group (not engaged in any sport) and 50 fighters (kung fu/karate, n = 29; judo, n = 21). All 79 subjects underwent anthropometric measures (weight, height, leg length, and height set) and dual-energy X-ray absorptiometry (BMD, in g/cm 2 ) at 2 moments, baseline and 9 months later. Maturity offset (age at peak height velocity), lean soft tissue, chronological age, and resistance training were treated as covariates. Male judoists presented higher gains in BMD-spine [0.098 g/cm 2 (95% confidence interval, 0.068-0.128)] than control group [0.040 g/cm 2 (95% confidence interval, 0.011-0.069)] (post hoc test with P = .030). There was no effect of martial art on BMD gains among girls. Independently of gender, in all multivariate models, lean soft tissue constituted the most relevant covariate. Judo practice in adolescents affected the bone accrual significantly after 9-month follow-up compared with controls, mainly in boys.

  19. Validation of the 12-gene colon cancer recurrence score in NSABP C-07 as a predictor of recurrence in patients with stage II and III colon cancer treated with fluorouracil and leucovorin (FU/LV) and FU/LV plus oxaliplatin.

    Science.gov (United States)

    Yothers, Greg; O'Connell, Michael J; Lee, Mark; Lopatin, Margarita; Clark-Langone, Kim M; Millward, Carl; Paik, Soonmyung; Sharif, Saima; Shak, Steven; Wolmark, Norman

    2013-12-20

    Accurate assessments of recurrence risk and absolute treatment benefit are needed to inform colon cancer adjuvant therapy. The 12-gene Recurrence Score assay has been validated in patients with stage II colon cancer from the Cancer and Leukemia Group B 9581 and Quick and Simple and Reliable (QUASAR) trials. We conducted an independent, prospectively designed clinical validation study of Recurrence Score, with prespecified end points and analysis plan, in archival specimens from patients with stage II and III colon cancer randomly assigned to fluorouracil (FU) or FU plus oxaliplatin in National Surgical Adjuvant Breast and Bowel Project C-07. Recurrence Score was assessed in 892 fixed, paraffin-embedded tumor specimens (randomly selected 50% of patients with tissue). Data were analyzed by Cox regression adjusting for stage and treatment. Continuous Recurrence Score predicted recurrence (hazard ratio for a 25-unit increase in score, 1.96; 95% CI, 1.50 to 2.55; P < .001), as well as disease-free and overall survival (both P < .001). Recurrence Score predicted recurrence risk (P = .001) after adjustment for stage, mismatch repair, nodes examined, grade, and treatment. Recurrence Score did not have significant interaction with stage (P = .90) or age (P = .76). Relative benefit of oxaliplatin was similar across the range of Recurrence Score (interaction P = .48); accordingly, absolute benefit of oxaliplatin increased with higher scores, most notably in patients with stage II and IIIA/B disease. The 12-gene Recurrence Score predicts recurrence risk in stage II and stage III colon cancer and provides additional information beyond conventional clinical and pathologic factors. Incorporating Recurrence Score into the clinical context may better inform adjuvant therapy decisions in stage III as well as stage II colon cancer.

  20. A validação do Teste de Juízo Moral (MJT para diferentes culturas: o caso brasileiro Moral Judgment Test (MJT adaptation for different cultures: Brazilian case

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    Patricia Unger Raphael Bataglia

    2010-04-01

    Full Text Available O presente artigo trata da adaptação do Teste de Juízo Moral (MJT para a língua portuguesa. São apresentados os princípios do teste, seu formato e o processo de validação de conteúdo, constructo e de critério. Da mesma forma, a confiabilidade é discutida utilizando os resultados das pesquisas brasileiras que inclusive geraram a necessidade de elaboração de outro dilema para compor o MJT-xt (estendido.The present article deals with the adaptation of the Moral Judgment Test (MJT for the Portuguese language. The principles of the test, its format and the process of content, construct and criterion validation are presented. In the same way, reliability is discussed using Brazilian research results that produced the necessity of elaborating another dilemma to compose the MJT-xt (extended.

  1. O feminicídio de juárez: alterações económicas, narrativas sociais e discursos coloniais na fronteira dos EUA e MÉXICO

    OpenAIRE

    Lobo, Patrícia Alves

    2016-01-01

    Desde maio de 1993 que, em Ciudad Juárez, centenas de mulheres foram assassinadas, violadas, torturadas e mutiladas e milhares continuam desaparecidas. Neste artigo, começa-se por evidenciar a interligação entre as alterações económicas geradas pelo Acordo de Comércio Livre da América do Norte e a destabilização dos papéis de género no norte do México, o que originou novos focos de violência contra as mulheres. Em segundo lugar, expõe-se a dialética que está subjacente aos modelos patriarcais...

  2. La relación entre el miedo a la violación y el sexismo benévolo en una muestra de mujeres de Ciudad Juárez (México)

    OpenAIRE

    Espinoza Ornelas, Roxana; Moya, Miguel; Willis, Guillermo B.

    2015-01-01

    En este artículo se estudió la relación entre el miedo a la violación y el sexismo benévolo en 2 muestras de mujeres de Ciudad Juárez (México). Usando un diseño correlacional, en el Estudio 1 (N = 225 mujeres) se encontró que cuanto mayor es el miedo a la violación, mayores puntuaciones se obtienen en sexismo benévolo, pero no en sexismo hostil. En el Estudio 2 (N = 188 mujeres) se manipuló experimentalmente el miedo considerando 3 condiciones: miedo a la violación, miedo al crimen y condició...

  3. Avaliação da densidade populacional e regeneração natural do palmito juçara (Euterpe edulis Mart. no município de São João Evangelista-MG

    Directory of Open Access Journals (Sweden)

    Paulo do Nascimento

    2015-07-01

    Full Text Available Este trabalho foi desenvolvido em uma população de E. edulis (palmito juçara em uma área de 4.5 hectares da fazenda Nova Granja de 363 hectares, em São João Evangelista, MG. Objetivou-se analisar a estrutura populacional dessa espécie em Floresta Estacional Semidecidual Montana, compreender sua dinâmica e contribuir com informações  sobre o manejo sustentado de E. edulis nesse tipo de ambiente. Os dados da população foram coletados em 10 parcelas de 10 x 15 m, alocadas em três transectos dispostos em nordeste-sudoeste, com 175 m de distância entre si. Coletaram-se dados referentes a cinco estádios de desenvolvimento (Jovem I, Jovem II, Imaturo I, Imaturo II e Adulto e avaliaram-se a densidade e a regeneração dessa população. Foi encontrado grande percentual de Jovem I. Adultos com altura de inserção foliar entre 14,3 e 18,3 m foram a classe mais frequente nessa população. A densidade populacional apresentou-se relativamente alta (0,74/m2; a população possui distribuição em “J” invertido, sendo uma população em estado natural de conservação. Palavras-chave: Palmeira juçara. “J” invertido. Arecaceae.

  4. Preliminary clinical evaluation of continuous infusion of 5-FU and low-dose cisplatin (LFP) therapy alone and combined with radiation therapy for treatment of advanced or recurrent esophageal cancer

    International Nuclear Information System (INIS)

    Itoh, Satoshi; Morita, Sojiro; Ohnishi, Takenao; Tsuji, Akihito; Takamatsu, Masahiro; Horimi, Tadashi

    2002-01-01

    We evaluated the clinical effect of 5-FU and low-dose Cisplatin (LFP) therapy alone and LFP therapy combined with radiation therapy in patients with advanced or recurrent esophageal cancer. From March 1995 to September 2000, 11 patients with inoperable esophageal cancer, 8 patients with adjuvant chemotherapy post operation, and 14 patients with recurrent esophageal cancer were treated with LFP therapy. 5-FU (160 mg/m 2 /day) was continuously infused over 24 hours, and CDDP (3-7 mg/m 2 /day) was infused for 30 minutes. The administration schedule consisted of 5-FU for 7 consecutive days and CDDP for 5 days followed by a 2-day rest, each for four weeks. We combined radiation therapy for the patients with all lesions that could be included in the radiation field. Of 30 patients with measurable lesions the response rates of LFP therapy alone and LFP therapy combined with radiation therapy were 33% and 60%, respectively. Toxicity over grade 3 appeared in 3 of 15 patients with LFP therapy combined with radiation therapy. There was no significant difference between LFP therapy alone and LFP therapy combined with radiation therapy with regard to survival rate of inoperable and recurrent esophageal cancer. In conclusion, LFP therapy alone may be effective for esophageal cancer. (author)

  5. Caracterización de las comunidades de acridios (Orthoptera: Acridoidea del partido de Benito Juárez, sudeste de la provincia de Buenos Aires, Argentina Grasshopper (Orthoptera: Acridoidea community structure in Benito Juárez county, in outhern Buenos Aires province, Argentina

    Directory of Open Access Journals (Sweden)

    María Laura de Wysiecki

    2004-12-01

    Full Text Available Se analizó la riqueza, densidad, constancia y distribución de especies de acridios, en distintas comunidades vegetales (1997-2002 en el partido de Benito Juárez, sudeste de la provincia de Buenos Aires. Las comunidades vegetales se categorizaron en pastizales nativos, comunidades halófilas, pasturas sin disturbio, pasturas con moderado disturbio y pasturas con alto disturbio. En total se registraron 23 especies de acridios. Los melanoplinos dominaron en casi todas las comunidades vegetales, excepto en las halófilas que se caracterizaron por la presencia de un acridino, Covasacris pallidinota (Bruner. La riqueza de especies promedio por sitio por año, varió entre 2,10 ± 0,60 especies en las pasturas con moderado disturbio y 6,20 ± 0,58 especies en las comunidades halófilas. La riqueza de especies acumulada fue de 17 en los pastizales nativos, 14 en las comunidades halófilas, 19 en las pasturas sin disturbio, 18 en las pasturas con moderado disturbio y 14 en las pasturas con alto disturbio. La densidad promedio de acridios fue máxima en el 2001 y 2002. Dichroplus pratensis Bruner y Dichroplus elongatus Giglio-Tos dominaron en los pastizales nativos y en las pasturas con alto disturbio, C. pallidinota en las comunidades halófilas, D. elongatus y Scotussa lemniscata (Stål en las pasturas sin disturbio y en las pasturas con moderado disturbio. La estructura taxonómica de las comunidades de acridios fue constante en los pastizales nativos, las comunidades halófilas y las pasturas. Hubo pocas especies de amplia distribución e intermedias y las raras fueron las más numerosas. De las 23 especies registradas en todos los sitios, D. elongatus fue la única de amplia distribución. Históricamente, para la zona de estudio, Dichroplus maculipennis (Blanch fue señalada como la especie dominante. Sin embargo, nuestros resultados sugieren que en la actualidad la especie dominante es D. elongatus. Si bien resulta imposible conocer las causas

  6. Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2.

    Science.gov (United States)

    Tan, Shu-Qiu; Geng, Xue; Liu, Jorn-Hon; Pan, Wynn Hwai-Tzong; Wang, Li-Xiang; Liu, Hui-Kang; Hu, Lei; Chao, Hsiao-Ming

    2017-07-14

    Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia. Retinal ischemia (I) was induced in Wistar rats by a high intraocular pressure (HIOP) of 120 mmHg for 1 h, which was followed by reperfusion of the ischemic eye; the fellow untreated eye acted as a control. Electroretinogram (ERG), biochemistry and histopathology investigations were performed. Significant ischemic changes occurred after ischemia including decreased ERG b-wave ratios, less numerous retinal ganglion cells (RGCs), reduced inner retinal thickness, fewer choline acetyltransferase (ChAT) labeled amacrine cell bodies, increased glial fibrillary acidic protein (GFAP) immunoreactivity and increased vimentin Müller immunolabeling. These were accompanied by significant increases in the mRNA/protein concentrations of vascular endothelium growth factor, hypoxia-inducible factor-1α, pyruvate kinase M2 and retinoblastoma-binding protein 2. The ischemic changes were concentration-dependently and significantly altered when XFZYD was given for seven consecutive days before or after retina ischemia, compared to vehicle. These alterations included enhanced ERG b-wave amplitudes, more numerous RGCs, enhanced inner retinal thickness, a greater number of ChAT immunolabeled amacrine cell bodies and decreased GFAP/vimentin immunoreactivity. Furthermore, decreased mRNA levels of VEGF, HIF-1α, PKM2, and RBP2 were also found. Reduced protein concentrations of VEGF, HIF-1α, PKM2, and RBP2 were also demonstrated. Furthermore, there was an inhibition of the ischemia-associated increased ratios (target protein/β-actin) in the protein levels of VEGF, HIF-1α, PKM2, and RBP2, which were induced by Shikonin, JIB-04 or Avastin. XFZYD would seem to protect against well-known retinal ischemic changes via a synergistic inhibition of RBP2 and PKM2, as well as down-regulation of HIF-1

  7. Estimating the terrestrial N processes in subtropical mountainous forestry catchment through INCA-N: A case study in FuShan catchment, Taiwan

    Science.gov (United States)

    Lu, Meng-Chang; Huang, -Chuan, Jr.; Chang, Chung-Te; Shih, Yu-Ting; Lin, Teng-Chiu

    2016-04-01

    The riverine DIN is a crucial indicator for eutrophication in river network. The riverine DIN export in Taiwan is featured by the extremely high yield, ~3800 kg-N km-2yr-1, nearly 20-fold than the global average, showing the interesting terrestrial N process yet rarely documented. In this study we collected the DIN samples in rainwater, soil water, and stream water in a mountainous forest watershed, FuShan experimental forest watershed 1 (WS1) which is a natural broadleaf forest without human activities. Based on the intensive observations, we applied the INCA-N to simulate the riverine DIN response and thus estimate the terrestrial N processes in a global synthesis. The result showed that both discharge and DIN yield were simulated well with the average Nash-Sutcliffe efficiency coefficient of 0.83 and 0.76 , respectively. Among all N processes, N uptake, mineralization, nitrification, denitrfication, and immobilization are significantly positive correlated with soil moisture (R2>0.99), which indicates that soil moisture greatly influences N cycle processes. The average rate of mineralization and nitrification in wet years are consistent with documented values, whereas the rates in dry years are lower than the observations. Despite the high nitrification rate, the secondary forest may uptake abundant N indicating the plant uptake, which responds for removing considerable nitrate, is a controlling factor in forest ecosystem. Our simulated denitrification rate falls between the documented rates of temperate forest and agricultural area, and that may be affected by the high N-deposition in Taiwan. Simulated in-stream denitrification rate is less than 10% of the rate in soil, and is a little lower than that in temperate forest. This preliminary simulation provides an insightful guide to establish the monitoring programme and improve the understanding of N cycle in subtropical.

  8. A RANDOMISED PLACEBO-EXERCISE CONTROLLED TRIAL OF KUNG FU TRAINING FOR IMPROVEMENTS IN BODY COMPOSITION IN OVERWEIGHT/OBESE ADOLESCENTS: THE

    Directory of Open Access Journals (Sweden)

    Tracey W. Tsang

    2009-03-01

    Full Text Available The purpose of the study was to investigate if Chinese martial arts (Kung Fu, KF might be effective for improving body composition, as well as being an appealing form of physical activity for inexperienced, sedentary, overweight/obese adolescents. Twenty subjects (age: 13.3 ± 1.8 y; BMI percentile: 98.6(86.5 - 99.8; 60% girls were randomly-assigned to the supervised KF or placebo (Tai Chi, TC control group 3 d.wk-1 for 6 months. We assessed body composition, including total and regional fat and lean mass, total and regional bone mineral density (BMD, percent lean and fat mass, body mass index and waist circumference, at baseline and after 6 months of training using anthropometry and dual-energy X-ray absorptiometry (DXA. Habitual physical activity and dietary intake were recorded as covariates via self-report at each time-point. As expected due to natural growth, significant increases in height, weight, total and lumbar BMD, and lean mass were seen in the cohort over time, with a trend for increased whole body fat mass, with no difference between groups. By contrast, percent fat and android fat mass via DXA did not increase in either group over time. The absence of a similar expected increase in central adiposity over 6 months could indicate a positive effect of participation in both programs on the metabolically critical abdominal adiposity in this cohort. Further research in this area is warranted to determine ways to increase uptake and compliance, and to see if longer-term martial arts training not only maintains, but improves abdominal fat mass and related metabolic health indices in overweight/ obese adolescents

  9. Title of paper: the induction of P-53 independent programmed cell death (apoptosis) with ionizing radiation and 5-fluorouracil (5-FU) in the HT-29 human colon carcinoma cell line

    International Nuclear Information System (INIS)

    Blackstock, A. Wm.; Gill, Misha; Hess, Suzanne M.; Fisher, Robert W.; Leadon, Steven A.; Tepper, Joel E.

    1996-01-01

    Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 cells were assessed for clonogenic survival after being plated at a variety of densities, and treated with single graded doses of radiation (0, 1, 2, 4, 6, 8, 10 Gy) either alone or immediately prior to a 24 hour exposure to 5-FU (2 ug/ml). The extent of radiation and 5-FU-induced apoptosis was determined in the HT-29 cell line after single doses of 0, 2, 5, and 10 Gy either alone or immediately prior to a 24 hour incubation in 5-FU (2 ug/ml). Three separate assays were used to evaluate the apoptotic response. Cells undergoing apoptosis undergo gross morphological changes including a condensation of chromatin, membrane blebbing, and an eventual release of membrane bound cytoplasmic fragments. Hematoxylin and eosin staining were used to visualize some of these morphological changes. Another characteristic of the apoptotic response is the activation of an endonuclease that cleaves DNA into specific fragments. Accordingly, an ELISA cell death assay (Boehringer Mannheim, Indianapolis IN) was used to quantitate cytoplasmic histone-associated DNA

  10. No fué suficiente

    Directory of Open Access Journals (Sweden)

    Gustavo Junca

    2000-05-01

    Full Text Available Crecimiento económico. Teoría, instituciones y experiencia internacional. Mónica Aparicio y William Easterly (coordinadores. Banco Mundial-Banco de la República, Bogotá, 1995,598 págs.

  11. Uncovering the Physical Basis Connecting Environment and Tribological Performance of Ultrananocrystalline Diamond

    Science.gov (United States)

    2012-10-05

    forces, bending moments and torsions . The stacking energy between adjacent base pairs is essentially van der Waal force interaction which is described...energy-based numerical analysis/prediction method adopted in this project is very flexible , effective, and robust, it is able to handle multi-scale...Vol. 42, No. 1, pp. 79-87 (SCI) Yeau-Ren Jeng, Tsung-Ting Lin, Hsiu-Ming Hsu, Hsin-Ju Chang, Dar-Bin Shieh, 2011, “ Human Enamel Rod Presents

  12. O poder dos juízes: Supremo Tribunal Federal e o desenho institucional do Conselho Nacional de Justiça The power of judges: the Supreme Court and the institutional design of the National Council of Justice

    Directory of Open Access Journals (Sweden)

    Ernani Carvalho

    2013-03-01

    Full Text Available Este artigo desenvolve o argumento de que o Conselho Nacional de Justiça (CNJ, criado no Brasil em 2004, foi fruto de um arranjo político com base na concretização da Reforma do Poder Judiciário. Neste arranjo os interesses do Supremo Tribunal Federal (STF prevaleceram sobre os demais e, por consequência, o resultado da emenda constitucional de número 45 foi um CNJ dirigido por integrantes da Corte maior brasileira. Para sua consecução utilizamos uma revisão da literatura especializada e análise de dados. O argumento é desenvolvido a partir da lógica de que aprovar um desenho institucional do CNJ atrelado aos interesses do STF é a melhor estratégia a ser desenvolvida pelos membros da Corte. Isto pode ser justificado por: 1 Os juízes do STF são importantes atores políticos; 2 A existência de uma independência judicial garantida por prerrogativas institucionais reforça ainda mais sua importância política; 3 Sistemas políticos com alto grau de fragmentação aumentam a probabilidade dos juízes (do STF emplacarem seus interesses; 4 A existência do mecanismo de revisão judicial amplia o grau de influência das Supremas Cortes e 5 Por fim, a existência de mecanismos informais de persuasão facilitam o êxito dos juízes do STF. A partir do caso estudado podemos constatar que: o desenho institucional brasileiro, que potencializa a possibilidade de intervenção judicial no processo decisório, e o sistema político altamente fragmentado geraram, em grande medida, uma Suprema Corte (STF poderosa e centralizadora do policy-making Judiciário, se tornando, neste aspecto, uma terceira câmara do processo decisório.This article argues that the National Council of Justice (CNJ, created in Brazil in 2004, was the result of a political arrangement based on the achievement of the Reform of the Judiciary. In this arrangement the interests of the Federal Supreme Court (STF prevailed over the others and therefore the result of a

  13. [Comparison of Curative Effect between Fu Fang Huang Dai Pian and Arsenic Trioxide in Treatment of 45 Patients with Acute Promyelocytic Leukaemia].

    Science.gov (United States)

    Wang, Jian; Huang, Jun-Bin; Liu, Zu-Lin; Zhang, Bi-Hong; Xu, Hong-Gui; Xue, Hong-Man; Chen, Chun

    2017-12-01

    To investigate the clinical efficacy of Fu Fan Huang Dai Pian(RIF) and arsenic trioxide (ATO) regimens for treatment of children with acute promyelocytic leukemia (APL) and to explore the risk factors affecting the prognosis of patients. The clinical data of 45 newly diagnosed APL children admitted in our hospital from January 2004 to May 2017 were analyzed retrospectively. Among 45 APL children, 25 children were treated by chemotherapetic regimen including RIF (RIF group), another 20 children were treated by chemotherapeutic regimen including ATO (ATO group). The follow-up was performed in all APL children. The prognosis and incidence of side reactions from drugs in 2 groups were compared, and the high risk factors affecting the prognosis of patients were analyzed. The median follow-up time was 49.8% months. In RIF group, no early death occured in 25 APL children; 5 cases did not achieve complete remission (CR) after induction therapy, CR rate was 88%. Out of 25 cases 2 caes relapsed, 3 cases died, 20 cases maintained contined CR (CCR), 2 cases failed to be followed-up. In ATO group, 2 cases suffered from early death, 5 cases did not achieve CR after induction therapy, CR rate was 90%, 2 caese relapsed and died, 15 cases maintained CCR, the follow-up failed in 1 caes. The 5 year- OS and EFS rate in all the patients were predicted as (82.2±6.2)% and (76.4±6.6)% respectively. The OS and EFS rate in RIF group were (86.1±7.4)% and (78.4±8.6)% respectively, which were significantly different from OS and EFS rate (76.4%±10.6%) and (74.0%±10.1%) respectively in ATO group (all P>0.05). As for the side reaction from drug, except for the cardiac damage (P0.05). In addition, the 5 year-OS and EFS rates in APL children with CNSL were significantly lower than those in APL children without CNSL (all Phigh risk were significantly lower than those in APL children reached M1 after induction therapy and with low and standerd risk (Ptreatment of APL children. The CNSL, poor

  14. ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways

    Directory of Open Access Journals (Sweden)

    Jia-Fu Ji

    2018-02-01

    Full Text Available Background/Aims: Nonalcoholic steatohepatitis includes steatosis along with liver inflammation, hepatocyte injury and fibrosis. In this study, we investigated the protective role and the potential mechanisms of a traditional Chinese medicine ShenFu (SF preparation in an in vitro hepatic steatosis model. Methods: In palmitic acid (PA-induced murine hepatic AML12 cell injury, effects of SF preparation on cellular apoptosis and intracellular triglyceride (iTG level were assessed using TUNEL and TG Colorimetric Assay. Reactive oxygen species (ROS and mitochondrial membrane potential (MMP levels were measured using DCF and JC-1 assay. Cytokine levels were evaluated using ELISA assay. Immunoblot was used to compare the activation level of c-Jun N terminal kinase (JNK, NADPH oxidase (Nox4, and NFκB pathways. Results: Addition of SF preparation prevented PA-mediated increase of apoptosis and iTG as well as IL-8 and IL-6. In PA-treated cell, SF preparation reduced the level of Nox4 and ROS, while increasing the level of MMP and the expression of manganese superoxide dismutase (MnSOD and catalase, indicating emendation of mitochondrial dysfunction. Nox4 inhibitor GKT137381 prevented PA-induced increase of ROS and apoptosis, while decreasing iTG slightly and not influencing the level of IL-8 and IL-6. SF preparation prevented PA-induced upregulation of phospho-JNK. JNK inhibitor SP600125 prevented PA-mediated increase of Nox4, IL-8, IL-6 and iTG. Nuclear translocation of NFκB/p65 was detected in PA-treated cells, which was prevented by SF preparation. An IκB degradation inhibitor, BAY11-7082, prevented PA-induced increase of IL-8 and IL-6 as well as iTG, whereas it only decreased ROS levels slightly and showed no influence on cellular apoptosis. Conclusion: SF preparation shows a beneficial role in prevention of hepatocyte injury by attenuating oxidative stress and cytokines production at least partially through inhibition of JNK/Nox4 and JNK

  15. Investigación epidemiológica sobre niveles de plomo en la población infantil y en el medio ambiente domiciliario de Ciudad Juárez, Chihuahua, en relación con una fundición de El Paso, Texas Epidemiologic study of lead levels in children and in the household environment in Ciudad Juárez, Chihuahua, México, and an area near a foundry in El Paso, Texas, USA

    Directory of Open Access Journals (Sweden)

    Blanca Raquel Ordóñez

    2003-01-01

    Full Text Available Se estudió una muestra representativa de los hogares de Ciudad Juárez y el 100% de los situados al noroeste de esa ciudad, cercanos a la fundición de El Paso, Texas, a determinar niveles de plomo en sangre por lo menos un niño de 1 a 9 años de edad de cada hogar, así como el plomo del polvo intradomiciliario y de la tierra de patios, jardines de la misma casa. Se estudió riesgo ocupacional y el de ingestión de plomo por uso de loza. Se encontró que los niveles de plomo en sangre eran mayores en los niños cuyos hogares se encontraban más próximos a la fundición. Hubo una correlación positiva entre niveles de plomo en sangre y el contenido del metal en el polvo intradomiciliario y en la tierra de sus patios o jardines, estos hechos no influyeron el riesgo ocupacional ni el uso de utensilios de loza que desprendieran plomo.A representative overall sampling of households in Ciudad Juárez, plus 100 per cent of the households in an area northwest of that city near a foundry in El Paso, Texas, were studied to determine the bloodlead level of at least one child within the 1-to-9 year age range in each home and the lead content of the dust inside the house and the dirt on its yard or grounds. The occupational risk was studied, as was the risk of lead intake from food prepared in enamel cooking utensils. Bloodlead levels were found to be highest in children whose homes were closest to the foundry. There was a positive correlation between bloodlead levels and the lead content of the dust in the home and the dirt in its yard or grounds. No association was established between the higher lead levels and occupational hazards or the use of enamel cooking utensils that give of lead.

  16. Tempo de jejuar e resistir: a presença do kung-fu no treinamento do ator : a experiência extracotidiana no teatro vocacional em proposição épica

    OpenAIRE

    Oliveira, Juliana Rocha de [UNESP

    2010-01-01

    Esta pesquisa surgiu da necessidade de registrar, organizar, sistematizar e relacionar os conhecimentos adquiridos em minha formação de atriz, professora de teatro e artista marcial, no intuito de melhor explorar o processo de criação teatral, utilizando técnicas marciais orientais. Aproximando as duas artes: teatral e marcial – kung fu, termo que além de designar uma arte marcial de origem chinesa possui outros significados como, por exemplo, capacidade de aguentar jejum e resistir, vislumbr...

  17. Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē.

    OpenAIRE

    Afoņičeva, Oksana

    2016-01-01

    Maģistra darba: “Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē” mērķis ir, izvērtējot pārdošanas veicināšanas ietekmi uz patērētāju uzvedību, lēmuma pieņemšanas procesu un uz patērētāju lojalitātes veidošanu, rast priekšlikumus pārdošanas veicināšanas iespējām pārtikas produktu zīmoliem. Darbs sastāv no četrām nodaļām- divām teorētiskajām, analītiskās un empīriskās. Pirmā izvirzītā hipotēze tiek apstiprināta, pama...

  18. Patērētāju uzvedības pētījums par ēdienu piegādes portālu Hungryhouse.co.uk kā e-komercijas dalībnieku.

    OpenAIRE

    Dembovska, Gerda

    2013-01-01

    Darba tēma -patērētāju uzvedības pētījums par ēdienu piegādes portālu Hungryhouse.co.uk kā e-komercijas dalībnieku. Autore apraksta patērētāja uzvedības izpētes un e-komercijas teorētiskos aspektus,analizē uzņēmuma Hungryhouse.co.uk. darbību Lielbritānijā,veic aptauju par Hungryhouse.co.uk.pastāvēšanas iespējām Latvijā. Darba mērķis -pamatojoties uz patērētāju uzvedības un e-komercijas teorētiskām atziņām,kā arī uz iedzīvotāju aptaujas rezultātiem, izpētīt ēdiena piegādes portāla Hungryho...

  19. Vīrieša tēls patērētāju priekšstatos: žurnāla "Klubs" 2014. gada reklāmu analīze

    OpenAIRE

    Blumberga, Lelde

    2015-01-01

    Bakalaura darba ”Vīriešu tēls patērētāju priekšstatos: žurnāla „Klubs” 2014. gada reklāmu analīze” mērķis ir noskaidrot, kāds vīrieša tēls tiek veidots vīriešu žurnālu reklāmas un tā patērētāja priekšstatos. Darba pētnieciskā problēma paredz, ka vīriešu tēls vīriešu žurnālos tiek pasniegts kā spilgts, veiksmīgs un ietekmīgs, kas var atstāt iespaidu uz patērētāja apziņu. Darbs sastāv no trīs daļām – teorētiskās, metodoloģiskās un empīriskās. Darba teorētiskajā daļā tiks apskatīta teorij...

  20. Evaluación del programa de médico cirujano del Instituto de Ciencias Biomédicas de la Universidad Autónoma de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Rafael Cataño-Calatayud

    Full Text Available Con el propósito de mejorar la calidad académica del programa de médico cirujano del Instituto de Ciencias de Biomédicas de la Universidad Autónoma de Ciudad Juárez (UACJ, en México, se modificó la manera de evaluar a los graduados. El programa de médico cirujano comprendía tres procesos de evaluación, que se utilizaron durante el periodo 2006-2008 para conocer la pertinencia, eficacia y eficiencia de la formación profesional de sus graduados: el promedio general de salida (PGS y el examen profesional ante pacientes (EPAP, evaluados por la UACJ, y el examen general para el obtención de la licenciatura (EGEL, evaluado por el Centro Nacional de Evaluación para la Educación Superior (CENEVAL. Se emplearon los procesos de evaluación con el fin de obtener un mejor perfil del grado. Se obtuvo una correlación entre el PGS y el EPAP, pero no con el EGEL, el cual tuvo una diferencia porcentual apreciable respecto a los otros dos procesos. Mientras que el EPAP reflejó los conocimientos obtenidos a lo largo del programa (comparado con el PGS, el EGEL mostró una diferencia marcada, probablemente, al evaluar con diversas puntuaciones las diferentes disciplinas del programa.

  1. Nebanku kredītdevēju ”SMScredit” un ”InCREDIT GROUP” lojalitātes programmas un to novērtējums

    OpenAIRE

    Birnbauma, Egija

    2016-01-01

    Bakalaura darba temats ir „Nebanku kredītdevēju ”SMScredit” un ”InCREDIT GROUP” lojalitātes programmas un to novērtējums.” Darba mērķis ir lojalitātes programmu komunikācijas kanālu vērtējums un klientu vērtējums par programmu noderīgumu, to priekšrocībām un vai programmu darbības principi klientiem ir saprotami. Darbs sastāv no trīs daļām: teorētiskās, metodoloģiskās un empīriskās daļas. Teorētiskajā daļā tiek pētīta literatūra par mārketingu, integrētā mārketinga komunikāciju, patērēt...

  2. Bērnu mārketinga attīstība Latvijas lielāko pārtikas produktu ražotāju tirgus darbībās

    OpenAIRE

    Lūse, Ieva

    2010-01-01

    Uzņēmumi visā pasaulē arvien vairāk sāka apzināties bērnu potenciālu tirgū un aktivizē savu komunikāciju ar bērnu auditoriju. Bērni vienlaicīgi tirgū pilda vairākas lomas kā patērētāji, iniciatori, ietekmētāji un lēmēji par pirkumu un pircēji šodien un nākotnē, kļūstot par daudzu uzņēmumu produkcijas pamata patērētājiem. Ņemot vērā tēmas aktualitāti autore par maģistra darba mērķi izvirza apzināt un analizēt lielāko Latvijas pārtikas produktu ražotāju aktivitāti bērnu mārketing...

  3. Performance of Hayabusa2 DCAM3-D Camera for Short-Range Imaging of SCI and Ejecta Curtain Generated from the Artificial Impact Crater Formed on Asteroid 162137 Ryugu (1999 JU3)

    Science.gov (United States)

    Ishibashi, K.; Shirai, K.; Ogawa, K.; Wada, K.; Honda, R.; Arakawa, M.; Sakatani, N.; Ikeda, Y.

    2017-07-01

    Deployable Camera 3-D (DCAM3-D) is a small high-resolution camera equipped on Deployable Camera 3 (DCAM3), one of the Hayabusa2 instruments. Hayabusa2 will explore asteroid 162137 Ryugu (1999 JU3) and conduct an impact experiment using a liner shooting device called Small Carry-on Impactor (SCI). DCAM3 will be detached from the Hayabusa2 spacecraft and observe the impact experiment. The purposes of the observation are to know the impact conditions, to estimate the surface structure of asteroid Ryugu, and to understand the physics of impact phenomena on low-gravity bodies. DCAM3-D requires high imaging performance because it has to image and detect multiple targets of different scale and radiance, i.e., the faint SCI before the shot from 1-km distance, the bright ejecta generated by the impact, and the asteroid. In this paper we report the evaluation of the performance of the CMOS imaging sensor and the optical system of DCAM3-D. We also describe the calibration of DCAM3-D. We confirmed that the imaging performance of DCAM3-D satisfies the required values to achieve the purposes of the observation.

  4. Para além da religião? Justiça de Deus, justiça do homem e as representações visuais do Juízo Final

    Directory of Open Access Journals (Sweden)

    Tamara Quírico

    2016-09-01

    Full Text Available O presente artigo inicia com um breve comentário sobre as relações entre o Cristianismo e imagens (que encontram suas origens ainda nos primeiros séculos da era cristã, analisando em seguida de forma sucinta questões ligadas às funções que se esperavam que imagens religiosas cumprissem no Ocidente medieval. Após essas considerações, o artigo analisará possíveis interpretações sócio-políticas de representações visuais do tema do Juízo Final especialmente nos últimos séculos da Idade Média, focando em particular exemplos produzidos na Península Itálica. Para tanto, discutirá brevemente os desenvolvimentos de conceitos como justiça e julgamento, mostrando como, ao fim, análises sócio-políticas dessas pinturas estariam necessariamente relacionadas também às funções religiosas dessas mesmas imagens.

  5. ¿La práctica de la siembra directa en cultivos de soja favorece las poblaciones de acridios (Orthoptera: Acrididae en el partido de Benito Juárez?

    Directory of Open Access Journals (Sweden)

    Daniel SCUFFI

    2012-01-01

    Full Text Available Considerando el desarrollo del cultivo de soja en siembra directa en el partido de Benito Juárez, y que algunos autores sostienen que esta práctica favorece los acridios, se evaluó la riqueza de especies y la abundancia en soja con siembra directa y convencional. Se registraron siete especies (Aleuas lineatus Stål, Covasacris pallidinota (Bruner, Baeacris pseudopunctulatus (Ronderos, Dichroplus elongatus Giglio-Tos, Dichroplus maculipennis (Blanchard, Dichroplus pratensis Bruner y Scotussa lemniscata (Stål. La riqueza de especies acumulada en los diferentes cultivos fue similar (p> 0,05. En soja de primera con siembra directa, se registraron 2,3 ± 0,19 especies, en soja de primera con siembra convencional 1,45 ± 0,15 especies y en soja de segunda con siembra directa 2,25 ± 0,28 especies. Dichroplus elongatus fue la especie más abundante en todos los cultivos y en todos los momentos. Las restantes presentaron baja abundancia y se registraron en algunos momentos. No existió diferencia (p> 0,05 en la abundancia de tucuras entre los cultivos y en las diferentes fechas de muestreo. La baja riqueza de especies registrada estaría relacionada con la baja diversidad vegetal de los cultivos. Este estudio no mostró diferencias en la abundancia y riqueza de especies de acuerdo a la labranza utilizada.

  6. Sporta preču zīmolu komunikācijas vērtējums sociālo mediju lietotāju auditorijā: "Nike", "Adidas", "Puma" gadījums

    OpenAIRE

    Mačane, Ieva

    2015-01-01

    Bakalaura darba „Sporta preču zīmolu komunikācijas vērtējums sociālo mediju lietotāju auditorijā: „Nike”, „Adidas”, „Puma” gadījums” mērķis ir noskaidrot un analizēt zīmolu komunikācijas paradumus un nozīmi, kā arī novērtēt auditorijas attieksmi par zīmolu īstenoto komunikāciju. Darba ietvaros tika analizēta zīmolu komunikācija sociālajos medijos facebook.com, instagram.com un twitter.com laika posmā no 2015.gada 1.janvāra līdz 31.martam. Darbā apkopota teorijas par zīmola un zīmolvedības...

  7. The Effect and Mechanism of Transdermal Penetration Enhancement of Fu's Cupping Therapy: New Physical Penetration Technology for Transdermal Administration with Traditional Chinese Medicine (TCM) Characteristics.

    Science.gov (United States)

    Xie, Wei-Jie; Zhang, Yong-Ping; Xu, Jian; Sun, Xiao-Bo; Yang, Fang-Fang

    2017-03-27

    In this paper, a new type of physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics is presented. Fu's cupping therapy (FCT), was established and studied using in vitro and in vivo experiments and the penetration effect and mechanism of FCT physical penetration technology was preliminarily discussed. With 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-ylacetic acid (indomethacin, IM) as a model drug, the establishment of high, medium, and low references was completed for the chemical permeation system via in vitro transdermal tests. Furthermore, using chemical penetration enhancers (CPEs) and iontophoresis as references, the percutaneous penetration effect of FCT for IM patches was evaluated using seven species of in vitro diffusion kinetics models and in vitro drug distribution; the IM quantitative analysis method in vivo was established using ultra-performance liquid chromatography-tandem mass spectrometry technology (UPLC-MS/MS), and pharmacokinetic parameters: area under the zero and first moment curves from 0 to last time t (AUC 0-t , AUMC 0-t ), area under the zero and first moment curves from 0 to infinity (AUC 0-∞ , AUMC 0-∞ ), maximum plasma concentration (C max ) and mean residence time (MRT), were used as indicators to evaluate the percutaneous penetration effect of FCT in vivo. Additionally, we used the 3 K factorial design to study the joint synergistic penetration effect on FCT and chemical penetration enhancers. Through scanning electron microscopy (SEM) and transmission electron microscope (TEM) imaging, micro- and ultrastructural changes on the surface of the stratum corneum (SC) were observed to explore the FCT penetration mechanism. In vitro and in vivo skin permeation experiments revealed that both the total cumulative percutaneous amount and in vivo percutaneous absorption amount of IM using FCT were greater than the amount using CPEs and iontophoresis. Firstly, compared with

  8. The Herb Medicine Formula “Chong Lou Fu Fang” Increases the Cytotoxicity of Chemotherapeutic Agents and Down-Regulates the Expression of Chemotherapeutic Agent Resistance-Related Genes in Human Gastric Cancer Cells In Vitro

    Directory of Open Access Journals (Sweden)

    Yongping Liu

    2011-01-01

    Full Text Available The herb medicine formula “Chong Lou Fu Fang” (CLFF has efficacy in inhibiting the proliferation of human gastric cancer in vitro and in vivo. To explore the potentially useful combination of CLFF with chemotherapeutic agents commonly used in gastric cancer therapy, we assess the interaction between CLFF and these chemotherapeutic agents in both SGC-7901 cell lines and BGC-823 cell lines using a median effect analysis and apoptosis analysis, and we also investigate the influence of CLFF on chemotherapeutic agent-associated gene expression. The synergistic analysis indicated that CLFF had a synergistic effect on the cytotoxicity of 5-fluorouracil (5-FU in a relative broad dose inhibition range (20–95% fraction affected in SGC-7901cell lines and 5–65% fraction affected in BGC-823 cell lines, while the synergistic interaction between CLFF and oxaliplatin or docetaxel only existed in a low dose inhibition range (≤50% fraction affected in both cell lines. Combination of CLFF and chemotherapeutic agents could also induce apoptosis in a synergistic manner. After 24 h, CLFF alone or CLFF combination with chemotherapeutic agents could significantly suppress the levels of expression of chemotherapeutic agent resistance related genes in gastric cancer cells. Our findings indicate that there are useful synergistic interactions between CLFF and chemotherapeutic agents in gastric cancer cells, and the possible mechanisms might be partially due to the down-regulation of chemotherapeutic agent resistance related genes and the synergistic apoptotic effect.

  9. Anti-mitotic potential of 7-diethylamino-3(2′-benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU

    International Nuclear Information System (INIS)

    Kim, Nam Hyun; Kim, Su-Nam; Oh, Joa Sub; Lee, Seokjoon; Kim, Yong Kee

    2012-01-01

    Highlights: ► DBC exerts antiproliferative potential against 5FU-resistant human gastric cancer cells. ► This effect is mediated by destabilization of microtubules and subsequent mitotic arrest. ► DBC enhances apoptosis via caspase activation and downregulation of antiapoptotic genes. -- Abstract: In this study, we investigate an anti-mitotic potential of the novel synthetic coumarin-based compound, 7-diethylamino-3(2′-benzoxazolyl)-coumarin, in 5-fluorouracil-resistant human gastric cancer cell line SNU-620-5FU and its parental cell SNU-620. It exerts the anti-proliferative effects with similar potencies against both cancer cells, which is mediated by destabilization of microtubules and subsequent mitotic arrest. Furthermore, this compound enhances caspase-dependent apoptotic cell death via decreased expression of anti-apoptotic genes. Taken together, our data strongly support anti-mitotic potential of 7-diethylamino-3(2′-benzoxazolyl)-coumarin against drug-resistant cancer cells which will prompt us to further develop as a novel microtubule inhibitor for drug-resistant cancer chemotherapy.

  10. INVESTIGACIONES ARQUEOLÓGICAS EN EL FORTÍN PESCADO, PARTIDO DE BENITO JUÁREZ, PROVINCIA DE BUENOS AIRES / Archaelogical research at Fortin Pescado, Benito Juárez county, Buenos Aires province

    Directory of Open Access Journals (Sweden)

    Vanesa Natalia Bagaloni

    2015-12-01

    Full Text Available En este trabajo se presentan los primeros resultados del estudio de los materiales recuperados en la localidad arqueológica Fortín Pescado, ubicada sobre la margen izquierda del arroyo Pescado Castigado, en el partido de Benito Juárez (provincia de Buenos Aires. Esta localidad se compone de dos sitios arqueológicos (Fortín Pescado 1 y Fortín Pescado 2 donde se efectuaron excavaciones y recolecciones en superficie y en el perfil de barrancas aledañas. El conjunto arqueológico de ambos sitios incluye restos faunísticos (mayormente animales domésticos, materiales vítreos (botellas cuadradas y cilíndricas, frascos, tarros y damajuanas, fragmentos de gres (botellas de ginebra y/o agua mineral, lozas (tazas y bowls ingleses, metales (clavos, botón, cuchilla y arma, ladrillos y un fragmento de bola de boleadora. Según diversos documentos escritos procedentes del Servicio Histórico del Ejército, del Archivo General de la Nación y del departamento de Geodesia, este fortín se instaló en 1858 y funcionó por lo menos hasta fines de 1863, cuando pasó a ser usado como posta militar hasta el fin de la década. A partir de las intervenciones arqueológicas y el relevamiento de las fuentes escritas se pudieron determinar áreas de actividades específicas (vivienda, descarte pautado y no pautado, corral dentro de esta localidad.  AbstractIn this paper the first results of the materials recovered at the Fortin Pescado archaeological locality are presented. This locality is situated on the left bank of Pescado Castigado stream (Benito Juárez County, Buenos Aires Province. It is composed by two sites (Fortin Pescado 1 and Fortin Pescado 2 where excavations and surface surveys were developed. Surface surveys were also conducted on the profiles of the surrounding canyons. The archaeological assemblages of both sites include faunal remains (mostly of domestic fauna/animals, glassy materials (square and cylindrical bottles, flasks, jars and jugs

  11. Aktualne poglądy na znaczenie neutrofilów w reumatoidalnym zapaleniu stawów. Wciąż neutrofile czy może już mikrofagi?

    Directory of Open Access Journals (Sweden)

    Michał Gajewski

    2011-10-01

    Full Text Available Poglądy na rolę neutrofilów w procesie zapalnym na przestrzeniostatnich lat uległy fundamentalnym zmianom. Neutrofile sąkrótko żyjącymi, finalnie zróżnicowanymi fagocytami. Ponieważw wyniku kontaktu z patogenem ulegają szybkiej aktywacji, nazywanesą często pierwszą linią obrony organizmu. Zaktywowaneneutrofile żyją już bardzo krótko, ulegając apoptozie (kamikazecells. W reumatoidalnym zapaleniu stawów neutrofile mogą byćfagocytowane przez makrofagi, tworząc charakterystyczne komórkiReitera. Ostatnio wykazano, że migracja neutrofilów do tkanekhamuje proces apoptozy, a tym samym ich przedłużająca się aktywnośćmoże skutkować znacznym wydłużeniem czasu trwania procesuzapalnego. Ponadto wykazano, że neutrofile nie są komórkamijedynie biernie odpowiadającymi na zewnętrzne sygnały, aleodgrywają aktywną rolę w inicjacji i regulacji procesu zapalnegopoprzez wydzielanie prozapalnych cytokin, ekspresję receptorówMHC klasy II, a tym samym biorą udział w aktywacji i kontroli aktywnościlimfocytów T. Wykazano istotne znaczenie neutrofilóww patogenezie takich chorób, jak przewlekła obturacyjna chorobapłuc, choroba Behçeta czy zapalenia stawów. Komórki te, w kontekścienajnowszej wiedzy o ich roli, powinny w przyszłości staćsię ważnym celem nowych terapii reumatoidalnego zapaleniastawów.

  12. A randomized phase II study of weekly nab-paclitaxel plus gemcitabine or simplified LV5FU2 as first-line therapy in patients with metastatic pancreatic cancer: the AFUGEM GERCOR trial.

    Science.gov (United States)

    Bachet, Jean-Baptiste; Chibaudel, Benoist; Bonnetain, Franck; Validire, Pierre; Hammel, Pascal; André, Thierry; Louvet, Christophe

    2015-10-06

    Metastatic pancreatic adenocarcinoma (PAC) prognosis remains dismal and gemcitabine monotherapy has been the standard treatment over the last decade. Currently, two first-line regimens are used in this setting: FOLFIRINOX and nab-paclitaxel plus gemcitabine. Increasing translational data on the predictive value of hENT1 for determining gemcitabine efficacy suggest that a non-gemcitabine-based regimen is favored in about 60 % of patients with PAC due to high resistance of PAC to this cytotoxic drug. This study aims to evaluate the efficacy of weekly nab-paclitaxel combined with gemcitabine or a simplified (s) LV5FU2 regimen in patients with previously untreated metastatic PAC. AFUGEM is a two-stage, open-label, randomized, multicenter, phase II trial. Patients with PAC who meet the inclusion criteria and provide written informed consent will be randomized in a 1:2 ratio to either nab-paclitaxel (125 mg/m(2)) plus gemcitabine (1000 mg/m(2)) given on days 1, 8, and 15 every 28 days or nab-paclitaxel (125 mg/m(2)) plus sLV5FU2 (leucovorin 400 mg/m(2) followed by bolus 400 mg/m(2) 5-fluorouracil and by 5-fluorouracil 2400 mg/m(2) as an 46-h intravenous infusion) given on days 1 and 15 every 28 days. A total of 114 patients will be randomized to one of the treatment arms. The primary endpoint is progression-free survival at 4 months. Secondary outcomes are rate and duration of response, disease control, overall survival, safety, and quality of life. Potential biomarkers of gemcitabine (hENT1, dCK) and 5-fluorouracil (TS) efficacy will be assessed. The AFUGEM trial is designed to provide valuable information regarding efficacy and tolerability of nab-paclitaxel plus gemcitabine and nab-paclitaxel plus sLV5FU2 regimens. Identification of potential predictive biomarkers of gemcitabine and 5-fluorouracil is likely to drive therapeutic decisions in patients with metastatic PAC. AFUGEM is registered at Clinicaltrials.gov: NCT01964534 , October 15, 2013.

  13. Using evidence on violence and injury prevention for policy development and decision making in Ciudad Juarez, Mexico Uso de información sobre prevención de la violencia y las lesiones para la formulación de políticas y la toma de decisiones en Ciudad Juárez, México

    Directory of Open Access Journals (Sweden)

    Luis Alberto Gutiérrez

    2012-05-01

    Full Text Available This report describes the implementation process and functional structure of the Observatory of Security and Citizen Conviviality of the Juarez Municipality (Observatorio de Seguridad y Convivencia Ciudadanas del Municipio de Juárez in Chihuahua, Mexico, and discusses the most relevant lessons learned and main challenges in the near future. The Observatory, created in 2008, is a joint effort of the Juarez Municipal Government, Autonomous University of Ciudad Juarez (Universidad Autónoma de Ciudad Juárez, and the Pan American Health Organization. The Observatory's main objective is to propose strategies and public policy recommendations to prevent and control violence and injuries in the Juarez Municipality. Most key federal, state, and local agencies have joined this independent autonomous citizen-based initiative, feed the databases, and benefit from the information produced by a multisectoral, multidisciplinary approach. The Observatory contributes far more than the technical data provided and its facilitating functions. The clear results obtained in such a short time-as seen in the preliminary results of the case study on road injuries from January 2009 to July 2011-demonstrate the appropriateness of this course of action and should stimulate the creation of new observatories whenever and wherever needed. Lessons learned, as discussed here, can open the way to new endeavors, and current challenges show how much work remains to be done.En este informe se describen el proceso de ejecución y la estructura funcional del Observatorio de Seguridad y Convivencia Ciudadanas del Municipio de Juárez, Chihuahua, México, y se presentan las enseñanzas extraídas más relevantes y los principales retos en un futuro próximo. El Observatorio, creado en el 2008, es un emprendimiento conjunto del gobierno del municipio de Juárez, la Universidad Autónoma de Ciudad Juárez y la Organización Panamericana de la Salud. El objetivo principal del

  14. Long-term outcomes of trimodality treatment for squamous cell carcinoma of the esophagus with cisplatin and/or 5-FU. More than 20 years' experience at a single institution

    Energy Technology Data Exchange (ETDEWEB)

    Fakhrian, Khashayar [Ruhr-Universitaet Bochum, Department of Radiation Oncology, Marien Hospital Herne and Sankt Josef Hospital Bochum, Bochum (Germany); Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Universitaetsklinikum der Ruhr-Universitaet Bochum, Klinik fuer Strahlentherapie und Radio-Onkologie, Marienhospital Herne, Herne (Germany); Ordu, Arif Deniz; Molls, Michael [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Lordick, Florian [University Clinic Leipzig, University Cancer Center Leipzig (UCCL), Leipzig (Germany); Technische Universitaet Muenchen, Department of Internal Medicine III (Hematology/Oncology), Munich (Germany); Theisen, Joerg [Technische Universitaet Muenchen, Department of Surgery, Klinikum rechts der Isar, Munich (Germany); Haller, Bernhard [Technische Universitaet Muenchen, Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Munich (Germany); Omrcen, Tomislav [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); University Hospital Split, Center of Oncology and Radiotherapy, Split (Croatia); Nieder, Carsten [Department of Oncology and Palliative Medicine, Nordland Hospital Trust, Bodoe (Norway); University of Tromsoe, Institute of Clinical Medicine, Faculty of Health Sciences, Tromsoe (Norway); Geinitz, Hans [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Krankenhaus der Barmherzigen Schwestern Linz, Department of Radiation Oncology, Linz (Austria)

    2014-12-15

    The purpose of this article is to report the outcome of neoadjuvant radiochemotherapy (N-RCT) + surgery in patients with squamous cell carcinoma of the esophagus at a single institution. We retrospectively reviewed data from patients who were referred to our department for N-RCT. From 1988-2011, 103 patients were treated with N-RCT with cisplatin and/or 5-fluorouracil (5-FU). Group 1: (n = 55) from 1988-2006 with 39.6-40 Gy and 5-FU with (n = 17) or without cisplatin (n = 38). Group 2: from 2003-2010 with 44-45 Gy and 5-FU with (n = 40) or without cisplatin (n = 8). All patients underwent radical resection with reconstruction according to tumor location and 2-field lymph node dissection. The degree of histomorphologic regression was defined as grade 1a (pCR, 0 % residual tumor), grade 1b (pSTR, < 10 % residual tumor), grade 2 (10-50 % residual tumor), and grade 3 (> 50 % residual tumor). Median follow-up time from the start of N-RCT was 100 months (range 2-213 months). The median overall survival (OS) for the whole cohort was 42 months and the 5-year OS was 45 ± 5 %. In the multivariate analysis, worse ECOG performance status (p < 0.001), weight loss > 10 % before the start of the N-RCT (p = 0.025), higher pT category (p = 0.001), and grade 2/3 pathologic remission (p < 0.001) were significantly associated with a poor OS. PCR and pSTR rates for group 1 were 36 % and 18 % compared to 53 % and 22 % for group 2 (p = 0.011). There was a tendency for a better outcome in group 2 patients without statistical significance. The 5-year OS, disease-free survival and recurrent-free survival were 36 ± 7 %, 35 ± 6, and 36 ± 7 % for group 1 and 55 ± 7, 49 ± 7, and 53 ± 7 in group 2 (p = 0.117, p = 0.124, and p = 0.087). There was no significant difference between the two groups considering the postoperative morbidity and mortality. Higher radiation doses and more use of simultaneous cisplatin lead to higher pathologic response rates to N-RCT and may be associated with

  15. De "los límites de la planeación urbana" a la definición del "modelo de gestión urbana en Ciudad Juárez"... ¿hacia un desarrollo sustentable al dominio de los "no lugares"?

    Directory of Open Access Journals (Sweden)

    Pedro Cital Beltrán

    2009-01-01

    Full Text Available En el presente ensayo se trata de hacer un breve recuento de las discusiones que se han presentado en algunos de los trabajos publicados en la revista Nóesis, particularmente los relacionados con desarrollo y planeación urbana, incluyendo las reflexiones sobre medio ambiente y vivienda. Asimismo, se presenta un balance respecto a las experiencias desarrolladas en los últimos años sobre este tema en Ciudad Juárez, en donde diversos acontecimientos han ido definiendo la configuración y el crecimiento de la localidad.

  16. Zawód przez zawodem – czy wypalenie może objawiać się już na studiach? Badanie populacji polskich studentów medycyny

    Directory of Open Access Journals (Sweden)

    Karolina Pieniawska

    2017-06-01

    Full Text Available Wstęp. Zapoczątkowane przez Herberta J. Freudenbergera pojęcie „wypalenie zawodowe” służy do określenia stanu wyczerpania jednostki, spowodowanego przez negatywne czynniki związane z pracą. Do grup zawodowych szczególnie na nie narażonych należą osoby wykonujące zawody związane z zaspokajaniem potrzeb ludzkich. Do tej grupy niewątpliwie należą lekarze, u których wypalenie stanowi poważny problem. Celem naszej pracy była odpowiedź na pytanie, czy objawy towarzyszące temu zjawisku można zaobserwować już u studentów kierunku lekarskiego, podczas ich studiów medycznych. Materiały i metody. Za pomocą autorskiej ankiety internetowej uzyskaliśmy odpowiedź zwrotną od 2388 studentów wydziałów lekarskich z całej Polski, z największym odsetkiem studentów Uniwersytetu Medycznego we Wrocławiu. Wyniki. Objawy towarzyszące wypaleniu były zgłaszane przez niepokojąco wysoki odsetek studentów, przy czym wzrost częstości ich występowania osiągał w większości przypadków kumulację na VI roku studiów lekarskich. Opinia o studiach lekarskich uległa u większości pogorszeniu po ich rozpoczęciu. Studenci są niezadowoleni ze sposobu prowadzenia zajęć na swoich uczelniach oraz wyrażają obawy o przyszłą pracę w zawodzie. Spory odsetek osób myśli również o wyjeździe za granicę po ukończeniu kierunku. Na pytanie o możliwość ponownego wyboru studiów, prawie 1/3 ankietowanych odpowiedziała, iż nie wybrałaby medycyny po raz kolejny. Wnioski. Niepokojące objawy występujące u studentów wymagają dokładniejszej analizy oraz wprowadzeniu prewencji wypalenia wśród tej populacji.

  17. Tegelikult olid pahad ju luterlased / Anti Selart

    Index Scriptorium Estoniae

    Selart, Anti, 1973-

    2010-01-01

    Arvustus: Fabricius, Dionysius. Dionysius Fabriciuse, Viljandi kiriku praosti Liivimaa ajaloo lühiülevaade neljas osas aastast tuhat ükssada viiskümmend kaheksa kuni aastani 1610 = Dionysii Fabricii, Praepositi pontificii Felinensis, Livonicae historiae compendiosa series in quatuor digesta partes ab anno millesimo centesimo quinquagesimo octavo usque ad annum MDCX. [Tartu] : Johannes Esto Ühing, 2010

  18. RE-SO--NANCEI-Ju-ne

    Indian Academy of Sciences (India)

    Woodward's Synthesis of Vitamin B'2. Adil Ghani Khan and S V Eswaran. Chemistry Behind the Life of a Transformer. Roshmi Sanghi. The Adive Lava Flows of Kilauea Volcano, Hawaii. Hetu Sheth. The Unexpeded Appearance of Pi in. Diverse Problems. Rajendra Bhatia. Acoustic Communication in Birds. Differences in ...

  19. RE-SONANCE--I-Ju-ne

    Indian Academy of Sciences (India)

    Is the Journal more Important than the Paper? One might believe that ... blame for the names of journals becoming more important than ... trend started by American scientists. Earlier ... on dance orientation and communication in the honey bee.

  20. R-ES-ONANCE--I-Ju-ne

    Indian Academy of Sciences (India)

    If you cut an apple the way most people cut an orange,2 the ~ore is seen to have the symmetry group D5". 2. Klein's Erlangen Programme. In 1872, at the University of Erlangen, Felix Klein de- livered a by-now very famous lecture, on a new way of looking at geometry; it has now become known as the. Leonardo da Vinci,.

  1. 6-----------------------------~--------------R-ES-ONANCEI--Ju-ne

    Indian Academy of Sciences (India)

    ultraviolet, because of the young stars (which are blue), would look redder when seen from such a distance, because of the reddening of light from the expansion of the universe. So, they took photographs of a patch of the sky in ultraviolet, blue and red filters, and looked for objects which looked very red (brighter in.

  2. 96----------------------------~-------------RESONAN-CE--I-Ju-ne

    Indian Academy of Sciences (India)

    at Cochin University of Science and Technology, Kochi 682 022, India sponspored by Indian Academy of Sciences, Bangalore 560 080, India. A Refresher Course on "Probability, Stochastic Processes and Applications" will be held at the Department of Mathematics, Cochin University of Science and Technology, Kochi.

  3. Korporatīvā sociālā atbildība: patērētāju uztveres un korporāciju komunikācijas analīze starptautiskajos tirgos uz McDonald's un Coca-Cola piemēra.

    OpenAIRE

    Teterins, Pāvels

    2016-01-01

    Korporatīvās sociālās atbildības (KSA) komunikācijas efektivitātes pamats ir pielāgošanās patērētāju prasībām. Pētījuma mērķis bija uz McDonald’s un Coca-Cola sociālo tīklu KSA komunikācijas piemēra, izvērtēt to, vai kompānijas pielāgo KSA komunikāciju patērētāju vērtējumam par atbildīgu uzņēmējdarbību, un piedāvāt optimālu KSA komunikācijas struktūru. Demogrāfisko faktoru ietekme uz Latvijas, Vācijas un Austrālijas KSA vērtējumu praktiski netika novērota. Savukārt, salīdzinot valstis savā st...

  4. A teoria de Kohlberg sobre o desenvolvimento do raciocínio moral e os instrumentos de avaliação de juízo e competência moral em uso no Brasil Kohlberg's theory about moral judgment development and the instruments used for evaluation of moral judgment and moral competence in Brazil

    Directory of Open Access Journals (Sweden)

    Patricia Unger Raphael Bataglia

    2010-04-01

    Full Text Available O presente artigo tem por objetivo abordar as bases, finalidades e composição de dois instrumentos de avaliação de juízo moral: a Moral Judgment Interview (MJI e o Defining Issues Test (DIT, e um de competência moral: o Moral Judgment Test (MJT. Retoma a teoria do desenvolvimento moral de Kohlberg que fundamenta esses instrumentos, assim como os últimos estudos realizados com os mesmos. A MJI é uma entrevista semiestruturada que avalia o nível de juízo moral. O DIT é um teste objetivo que mede a proporção de respostas pós-convencionais. O MJT é um instrumento objetivo, que avalia a competência moral. Destaca-se a crescente utilização desses instrumentos em pesquisas sobre moralidade.This paper presents intends to address the objectives and composition of two instruments for evaluation of moral judgment: the "Moral Judgment Interview" (MJI and the "Defining Issues Test" (DIT and one for moral competence measurement: the "Moral Judgment Test" (MJT. It retakes Kohlberg's moral development theory which gives the foundation for these instruments. Presents Brazilian studies with each instrument. MJI is a semi-structured interview that evaluates the stage of moral judgment. DIT is an objective test that measures the percentage of post-conventional answers. MJT is an objective instrument that measures the moral judgment competence. Researches have used more and more these instruments.

  5. Continuous infusion (CI) 5-FU and leucovorin (LCV) combined with hepatic (H), nodal (N), and tumor bed (TB) irradiation (XRT) following pancreaticoduodenectomy (PDD) for head of pancreas (HOP) and other periampullary (PA) adenocarcinoma

    International Nuclear Information System (INIS)

    Abrams, R.A.; Yeo, C.J.; Grochow, L.B.; Chakravarthy, A.; Sohn, T.A.; Zahurek, M.L.; Haulk, T.; Ord, S.; Hruban, R.H.; Lillemoe, K.D.; Pitt, H.A.; Cameron, J.L.

    1996-01-01

    Purpose: To make preliminary assessment of whether use of this regimen in the post PDD adjuvant context is associated with: (1) an acceptable toxicity profile and (2) encouraging survival results as compared to either no or standard (GITSG) adjuvant (adj) therapy. Methods: From 10/1/91 through 9/30/95 28 post PDD patients (pts) (21 HOP, 7 PA) received adj chemoxrt with CI 5-FU (200 mg/m 2 ) and LCV (5 mg/m 2 ) via a semi-permanent central line Monday thru Friday along with H, N, and TB XRT. The first 18 pts received XRT doses of 2340 cGy (H) and 5040 cGy (N and TB). The last 10 pts received XRT doses of 2700 cGy (H), 5400 cGy (N), and 5760 cGy (TB). Fraction size = 180 cGy. XRT was administered after computerized and CAT scan based planning using 6 MV or greater photon energy. Therapy began within 10 wks of PDD. 1 month following chemoxrt, pts were to begin the first of 4 monthly cycles of 5-FU/LCV given without xrt but at the same doses and scheduled Monday thru Friday for 2 weeks on followed by 2 weeks off. Results: (M(F)) ratio (12(16)). The median age was 58 yrs (range 44-76). 23 pts had +ve nodes (10 pts had 5 or more +ve nodes). 6 pts had microscopically +ve resection margins of whom 5 also had +ve nodes. 26 pts completed chemoxrt as planned. 1 pt failed to complete chemoxrt due to the onset of immune thrombocytopenia. 1 pt completed after delay due to family death. 15 pts did not complete the planned 4 cycles of 5-FU/LCV (9-disease progression on therapy, 3-toxicity, 3-other). 9 pts had IV catheter problems. 7 pts had mild to moderate emotional depression while on therapy. Pts were monitored for wt loss, decline in performance status, liver, GI, heme, esophageal, oral mucosal and hand/foot toxicities. There were no grade (4(5)) toxicities. The only grade 3 toxicities were hepatic (3 pts) (elevations in AST, ALT, OR ALK PHOS without jaundice or hepatic failure). Median actuarial survival for these 28 pts was 15 months (20 pts deceased). For the 21 HOP pts

  6. Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy

    International Nuclear Information System (INIS)

    Godai, Ten-i; Sakuma, Yuji; Tsuchiya, Eiju; Kameda, Yoichi; Akaike, Makoto; Miyagi, Yohei; Suda, Tetsuji; Sugano, Nobuhiro; Tsuchida, Kazuhito; Shiozawa, Manabu; Sekiguchi, Hironobu; Sekiyama, Akiko; Yoshihara, Mitsuyo; Matsukuma, Shoichi

    2009-01-01

    Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therapy have not been identified. Previous in vitro and clinical investigations reported that CRC patients with wild-type p53 gene (TP53)-tumors benefit from 5-fluorouracil (5-FU) based chemotherapy, while those with mutated TP53-tumors do not. However, these studies evaluated the mutation-status of TP53 by immunohistochemistry with or without single-strand conformation polymorphism, and the mutation frequency was different from study to study. In addition, the polymorphic status at p53 codon 72, which results in arginine or proline residues (R72P) and is thought to influence the function of the protein significantly, was not examined. To evaluate the significance of the TP53 mutation as a molecular marker to predict the prognosis of CRC patients, especially those who received postoperative chemotherapy, we examined the mutation by direct sequencing from fresh CRC tumors and evaluated the R72P polymorphism of the mutated TP53 by a combined mutant allele- and polymorphic allele-specific polymerase chain reaction (PCR). The TP53 mutation occurred in 147 (70%) of 211 Japanese CRC tumors. The mutation was observed in 93 (63%) tumors on the R72 allele and in 54 (37%) tumors on the P72 allele. Although the alterations to TP53 have no prognostic significance for CRC patients overall, we found that Dukes' stage C CRC patients who did not receive postoperative chemotherapy and carried the mutated TP53-R72 showed significantly longer survival times than those with the mutated TP53-P72 when evaluated by overall survival (p = 0.012). Using a combined mutant allele- and polymorphic allele-specific PCR, we defined the codon 72 polymorphic status of the TP53 mutated allele in Japanese CRC patients. We raised a possibility that Dukes' stage C colorectal cancer

  7. Etiología de la infección cérvico vaginal en pacientes del Hospital Juárez de México Etiology of cervicovaginal infection in Mexican women

    Directory of Open Access Journals (Sweden)

    Rocío Flores-Paz

    2003-01-01

    Full Text Available OBJETIVO: Conocer la etiología de la infección cérvico vaginal, con el fin de establecer un diagnóstico acertado que permita ofrecer a las pacientes el tratamiento más apropiado. MATERIAL Y MÉTODOS: De enero de 1995 a diciembre de 1999 se realizó un estudio bacteriológico a 6 811 muestras de exudado cérvico vaginal de pacientes del Hospital Juárez de México, de la Ciudad de México, con edades comprendidas entre los 13 y los 65 años, que referían leucorrea, prurito, hiperemia y dolor abdominal bajo. RESULTADOS: La frecuencia de infección por cada germen fue G vaginalis, 22.65%, Candida spp, 19.13%, C albicans, 7.8%, T vaginalis, 1.5%, Streptococcus del grupo D, 11.78%, Streptococcus b haemolyticus, 4.59%, E coli, 13.46%, Klebsiella ssp, 2.0%, además de otras enterobacterias menos frecuentes como Citrobacter spp, Enterobacter spp, Pseudomonas spp, M morganii y P mirabilis. El 2.9% presentó anaerobios siempre asociados con G vaginalis. Se aislaron Neisseria spp y N weaveri en 0.15% de las muestras. La N gonorrhoeae no se encontró en ningún caso. Datos comparativos indican que, tanto Streptococcus hemoliticos como E coli tuvieron un marcado incremento en los dos últimos años, siendo el de esta última estadísticamente significativo (pOBJECTIVE: To identify the etiologic agents of cervicovaginal infection in order to establish an accurate diagnosis and proper treatment. MATERIAL AND METHODS: From January 1995 to December 1999, bacteriological studies were done in cervical discharge specimens from 6 811 patients aged 13 to 65 years, seen at Hospital Juarez in Mexico City. All patients had leucorrhea, pruritus, hyperemia, and abdominal pain. Statistical significance was assessed using the chi-squared test. RESULTS: The frequencies of infectious agents were as follows: G. vaginalis, 22.65%, Candida spp, 19.13%, C. albicans, 7.8%, T. vaginalis, 1.5%, Streptococcus group D, 11.78%, Streptococcus b hemolytic, 4.59%, E. coli, 13

  8. Identity of Innovative Multifunctional Material Manufacturing Business in Latvia / Inovatīvu Daudzfunkcionālo Materiālu Ražotāju Identitāte Latvijā

    Science.gov (United States)

    Geipele, I.; Staube, T.; Ciemleja, G.; Zeltins, N.; Ekmanis, Yu.

    2015-08-01

    The publication comprises the results from the practical scientific investigation to define the profile and distinctions of the Latvian innovative multifunctional material manufacturing industry. The research is carried out by a holistic approach, including expert interviews, qualitative analysis of the official register data, practical survey, and financial data analysis. The paper seeks to give the detailed data on a technological profile of the mentioned representative companies, if there is a synergy or tough competition in the Latvian market. The current research is topical, because it is unique and does not have analogues in Latvia, and the research is timely due to correspondence with recently stated Research and Innovation Strategies for Smart Specialisation in Latvia. The main findings are associated with recognition of the factors that make impact on commercialisation of the finished goods, obtained financial results and planned directions of development of the respondent companies. Publikācija sniedz veiktā zinātniski praktiskā pētījuma rezultātus, kura ietvaros tika noteikts Latvijas inovatīvu daudzfunkcionālo materiālu ražotāju darbības profils un identitāte. Pētījumā tika izmantota kompleksās analīzes metode, kas ietvēra ekspertu intervijas, uzņēmumu oficiāli reģistrēto datu kvalitatīvo analīzi, zinātniski praktisko aptauju, kā arī pētāmo uzņēmumu finanšu darbības rezultātu analīzi. Zinātniskais darbs sniedz izsmeļošu informāciju par mērķa uzņēmumu tehnoloģisko profilu un pēta, vai Latvijas mērķa ražošanas nozarē ir sinerģijas vai sīvās konkurences pazīmes. Šim zinātniskajam pētījumam ir noteikta aktualitāte saskaņā ar tā unikalitāti Latvijas valsts mērogā un atbilstība Viedās specializācijas stratēģijai. Pētījuma galvenie secinājumi ir saistīti ar uzņēmumu produkcijas komercializācijas ietekmējošo faktoru apzināšanu, sasniegtajiem finansiālajiem rezultātiem un pl

  9. Degradation of 5-FU by means of advanced (photo)oxidation processes: UV/H{sub 2}O{sub 2}, UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2} — Comparison of transformation products, ready biodegradability and toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Lutterbeck, Carlos Alexandre, E-mail: lutterbeck@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Graduate Program in Environmental Technology, Universidade de Santa Cruz do Sul — UNISC, Av. Independência, 2293, CEP 96815-900 Santa Cruz do Sul, Rio Grande do Sul (Brazil); Wilde, Marcelo Luís, E-mail: wilde@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Baginska, Ewelina, E-mail: ewelina.baginska@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Leder, Christoph, E-mail: cleder@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Machado, Ênio Leandro, E-mail: enio@unisc.br [Graduate Program in Environmental Technology, Universidade de Santa Cruz do Sul — UNISC, Av. Independência, 2293, CEP 96815-900 Santa Cruz do Sul, Rio Grande do Sul (Brazil); and others

    2015-09-15

    The present study investigates the degradation of the antimetabolite 5-fluorouracil (5-FU) by three different advanced photo oxidation processes: UV/H{sub 2}O{sub 2}, UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2}. Prescreening experiments varying the H{sub 2}O{sub 2} and TiO{sub 2} concentrations were performed in order to set the best catalyst concentrations in the UV/H{sub 2}O{sub 2} and UV/TiO{sub 2} experiments, whereas the UV/Fe{sup 2+}/H{sub 2}O{sub 2} process was optimized varying the pH, Fe{sup 2+} and H{sub 2}O{sub 2} concentrations by means of the Box–Behnken design (BBD). 5-FU was quickly removed in all the irradiation experiments. The UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2} processes achieved the highest degree of mineralization, whereas the lowest one resulted from the UV/H{sub 2}O{sub 2} treatment. Six transformation products were formed during the advanced (photo)oxidation processes and identified using low and high resolution mass spectrometry. Most of them were formed and further eliminated during the reactions. The parent compound of 5-FU was not biodegraded, whereas the photolytic mixture formed in the UV/H{sub 2}O{sub 2} treatment after 256 min showed a noticeable improvement of the biodegradability in the closed bottle test (CBT) and was nontoxic towards Vibrio fischeri. In silico predictions showed positive alerts for mutagenic and genotoxic effects of 5-FU. In contrast, several of the transformation products (TPs) generated along the processes did not provide indications for mutagenic or genotoxic activity. One exception was TP with m/z 146 with positive alerts in several models of bacterial mutagenicity which could demand further experimental testing. Results demonstrate that advanced treatment can eliminate parent compounds and its toxicity. However, transformation products formed can still be toxic. Therefore toxicity screening after advanced treatment is recommendable. - Highlights: • Full primary elimination of 5-FU was

  10. Adjuvant post-operative radiotherapy vs radiotherapy plus 5-FU and levamisole in patients with TNM stage II-III resectable rectal cancer. A phase III randomized clinical trial

    Energy Technology Data Exchange (ETDEWEB)

    Cafiero, F.; Gipponi, M.; Di Somma, C. [Istituto Nazionale per la Ricerca sul Cancro, Geneo (Italy). Istituto di Oncologia Clinica] [and others

    1995-08-01

    Loco-regional and distant relapses contribute to impair the outcome of rectal cancer patients. As to the former, either pre-or post-operative radiation therapy (RT) significantly reduce loco-regional recurrence; post-operative chemotherapy (CT), alone or in different combinations with RT, is effective in improving both disease-free survival and survival. However, many drawbacks still exist regarding the method of RT delivery as well as the toxicity of combination adjuvant chemotherapy. The aim of this trial is to assess the effectiveness and toxicity of adjuvant post-operative RT vs combined RT and CT (5-FU plus levamisole) in patients with TNM stage II-III resectable rectal cancer (pT3-4, pN0, M0; pT1-4, pN1-3, M0). The primary endpoint is overall survival; secondary endpoints are disease-free survival rate of loco-regional recurrence, and treatment-related toxicity/morbidity. (author).

  11. Simultaneous Qualitative and Quantitative Analysis of Multiple Chemical Constituents in YiQiFuMai Injection by Ultra-Fast Liquid Chromatography Coupled with Ion Trap Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Chunhua Liu

    2016-05-01

    Full Text Available YiQiFuMai injection (YQFM is a modern lyophilized powder preparation derived from the traditional Chinese medicine Sheng-mai san (SMS used for treating cardiovascular diseases, such as chronic heart failure. However, its chemical composition has not been fully elucidated, particularly for the preparation derived from Ophiopogon japonicus. This study aimed to establish a systematic and reliable method to quickly and simultaneously analyze the chemical constituents in YQFM by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UFLC-IT-TOF/MS. Sixty-five compounds in YQFM were tentatively identified by comparison with reference substances or literature data. Furthermore, twenty-one compounds, including three ophiopogonins, fifteen ginsenosides and three lignans were quantified by UFLC-IT-TOF/MS. Notably, this is the first determination of steroidal saponins from O. japonicus in YQFM. The relative standard deviations (RSDs of intra- and inter-day precision, reproducibility and stability were <4.9% and all analytes showed good linearity (R2 ≥ 0.9952 and acceptable recovery of 91.8%–104.2% (RSD ≤ 5.4%, indicating that the methods were reliable. These methods were successfully applied to quantitative analysis of ten batches of YQFM. The developed approach can provide useful and comprehensive information for quality control, further mechanistic studies in vivo and clinical application of YQFM.

  12. A ponderação de direitos fundamentais como critério para o controle jurisdicional de políticas públicas: decisionismo (leia-se ativismo judicial ou juízo fundamentado? uma análise da jurisprudência do Supremo Tribunal Federal

    Directory of Open Access Journals (Sweden)

    Mônia Clarissa Leal

    2012-08-01

    Full Text Available Em tempos de neoconstitucionalismo, em que os ordenamentos jurídico-constitucionais são marcados por um caráter principiológico, os Tribunais Constitucionais ganham destaque, sendo, contudo, objeto de críticas, pautadas, sobretudo, na ausência de critérios objetivos para a ponderação e na extensão dada à atuação do magistrado, que abriria caminho para o assim chamado “ativismo judicial”. Neste contexto é que se pretende analisar a atuação do Supremo Tribunal Federal brasileiro, a fim de verificar-se até que ponto suas decisões observam os elementos da ponderação, constituindo-se em juízos fundamentados, ou se caracterizam como simples “decisionismo”, que poderia ser classificado como uma espécie de ativismo judicial.

  13. Televīzijas loma neapmierinātībā ar politiku: LTV1, LNT, TV3 nedēļas analītisko raidījumu satura, to veidotāju un ekspertu vērtējumu analīze (2008.gada oktobris-2009.gada marts)

    OpenAIRE

    Novodvorskis, Vladimirs

    2009-01-01

    Maģistra darbu „Televīzijas loma neapmierinātībā ar politiku: LTV1, LNT, TV3 nedēļas analītisko raidījumu satura, to veidotāju un ekspertu vērtējumu analīze (2008. gada oktobris – 2009. gada marts)” izstrādāja Latvijas Universitātes Komunikācijas studiju nodaļas students Vladimirs Novodvorskis. Darbs veltīts auditorijas negatīvas attieksmes veidošanas problēmas izpētei televīzijas informatīvi analītiskajos raidījumos Panorāma, De facto (LTV1), LNT Top 10 (LNT), Nekā personīga (TV3) pret pol...

  14. EFECTO DEL MÉTODO DE ESTIRAMIENTO PNF Y ESTÁTICO EN LA MEJORA DE LA FLEXIBILIDAD DE LA ARTICULACIÓN DE LA CADERA EN PRACTICANTES DE KUNG FU

    Directory of Open Access Journals (Sweden)

    Juan Diego Zamora Salas

    2001-12-01

    Full Text Available El presente estudio analizó el efecto de dos métodos de estiramiento (estático y P.N.F. para mejorar el rango de movimiento en la articulación de la cadera en practicantes de Kung Fu Wing Chun, utilizando una prueba de flexibilidad de cadera. Se formaron tres grupos cada uno conformado por n= 10, cuyas edades estaban comprendidas entre los 15 y 28 años. Los sujetos del Grupo Control les correspondía continuar con sus entrenamientos normalmente; y a los sujetos del Grupo B y Grupo C, les correspondía realizar la prueba de flexibilidad de la cadera utilizando el método estático y el método P.N.F. respectivamente. A los valores recolectados durante la prueba se les aplicó una Anova 3x3, Análisis de Efecto Simple para Grupos y Mediciones, además de un análisis de Tukey, en donde se encontró una mejora de los resultados tanto en el grupo que utilizó el método estático como para el que utilizó el método P.N.F., en comparación al grupo control, pero no existiendo una diferencia significativa entre ambos métodos, sólo entre el pre-test y post-test de ambos tratamientos. También se encontró una mayor retención de la mejora en el R.M.A.; en los sujetos que utilizaron el método P.N.F., cuatro semanas después de haberse suspendido éste método en comparación a los sujetos que utilizaron el método estático.

  15. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics.

    Science.gov (United States)

    Liu, Pei; Li, Zhenhao; Qian, Dawei; Li, Wei; Shang, Er-Xin; Duan, Jin-Ao

    2013-06-15

    A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of the three main bioactive compounds, i.e., ligustilide, dehydrocostuslactone and α-cyperone in dog plasma after oral administration of the essential oil of Xiang-Fu-Si-Wu Formula (XEO). Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mLmin(-1), using 0.1% formic acid-acetonitrile as mobile phase. The MS/MS ion transit ions monitored were 190.5→90.9 for ligustilide, 231.1→185.1 for dehydrocostuslactone, 219.2→123.0 for α-cyperone and 748.5→158.1 for IS. Method validation was performed as per Food and Drug Administration guidelines and the results met the acceptance criteria. The lower limit of quantification (LLOQ) achieved was 5.12ng/mL for ligustilide, 1.06ng/mL for dehydrocostuslactone and 1.89ng/mL for α-cyperone, respectively, and the calibration curves obtained were linear (r>0.99) over the concentration range approximately 1-1000ng/mL. The intra- and inter-day precision was less than 15% and the accuracy was within ±9.2%. After validation, this method was successfully applied to a pharmacokinetic study where dogs were orally given 0.3g/kg XEO, equivalent to 183.6mg/kg of ligustilide, 5.0mg/kg of dehydrocostuslactone and 26.2mg/kg of α-cyperone, respectively. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients.

    Science.gov (United States)

    Battaglin, Francesca; Schirripa, Marta; Buggin, Federica; Pietrantonio, Filippo; Morano, Federica; Boscolo, Giorgia; Tonini, Giuseppe; Lutrino, Eufemia Stefania; Lucchetti, Jessica; Salvatore, Lisa; Passardi, Alessandro; Cremolini, Chiara; Arnoldi, Ermenegildo; Scartozzi, Mario; Pella, Nicoletta; Boni, Luca; Bergamo, Francesca; Zagonel, Vittorina; Loupakis, Fotios; Lonardi, Sara

    2018-01-25

    Few data are available regarding the treatment of metastatic colorectal cancer elderly patients with anti-EGFR agents in combination with chemotherapy. FOLFOX plus panitumumab is a standard first-line option for RAS wild-type metastatic colorectal cancer. Slight adjustments in chemo-dosage are commonly applied in clinical practice to elderly patients, but those modified schedules have never been prospectively tested. Clinical definition of elderly (≥70 years old) patients that may deserve a more or less intensive combination therapy is still debated. Several geriatric screening tools have been developed to predict survival and risk of toxicity from treatment. Among those, the G8 screening tool has been tested in cancer patients showing the strongest prognostic value for overall survival, while the CRASH score can stratify patients according to an estimated risk of treatment-related toxicities. The PANDA study is a prospective, open-label, multicenter, randomized phase II trial of first-line therapy with panitumumab in combination with dose-adjusted FOLFOX or with 5-fluorouracil monotherapy, in previously untreated elderly patients (≥70 years) with RAS and BRAF wild-type unresectable metastatic colorectal cancer. RAS and BRAF analyses are centralized. Geriatric assessment by means of G8 and CRASH score is planned at baseline and G8 will be re-evaluated at disease progression. The primary endpoint is duration of progression-free survival in both arms. Secondary endpoints include prospective evaluation of the prognostic role of G8 score and the correlation of CRASH risk categories with toxicity. The PANDA study aims at exploring safety and efficacy of panitumumab in combination with FOLFOX or with 5FU/LV in elderly patients affected by RAS and BRAF wild-type metastatic colorectal cancer, to identify the most promising treatment strategy in this setting. Additionally, this is the first trial in which the prognostic role of the G8 score will be prospectively

  17. Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang-Fu-Si-Wu Decoction effective fraction in normal and dysmenorrheal symptom rats.

    Science.gov (United States)

    Liu, Pei; Li, Wei; Li, Zhen-hao; Qian, Da-wei; Guo, Jian-ming; Shang, Er-xin; Su, Shu-lan; Tang, Yu-ping; Duan, Jin-ao

    2014-07-03

    Xiang-Fu-Si-Wu Decoction (XFSWD) has been widely used to treat primary dysmenorrhea in clinical practice for hundreds of years and shown great efficacy. One fraction of XFSWD, which was an elution product by macroporous adsorption resin from aqueous extract solution with 60% ethanol (XFSWE), showed great analgesic effect. The present study was conducted to investigate the possible pharmacokinetic and tissue distribution profiles of four major bioactive constituents (berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine) after oral administration of XFSWE in dysmenorrheal symptom rats, and to compare the difference between normal and dysmenorrheal symptom rats. Estradiol benzoate and oxytocin were used to produce dysmenorrheal symptom rat model. The experimental period was seven days. At the final day of experimental period, both normal and dysmenorrheal symptom rats were orally administrated with XFSWE, and then the blood and tissues samples were collected at different time points. Berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine in blood and tissue samples were determined by LC-MS/MS. Pharmacokinetic parameters were calculated from the plasma concentration-time data using non-compartmental methods. The differences of pharmacokinetic parameters among groups were tested by one-way analysis of variance (ANOVA). There were statistically significant differences (Pnormal and dysmenorrheal symptom rats that orally administered with same dosage of XFSWE. In tissue distribution study, the results showed that the overall trend was C(Spleen)>C(Liver)>C(Kidney)>C(Uterus)>C(Heart)>C(Lung)>C(Ovary)>C(Brain)>C(Thymus), C(M-60 min)>C(M-120 min)>C(M-30 min)>C(C-60 min)>C(C-120 min)>C(C-30 min). The contents of protopine in liver, spleen and uterus were more than that in other tissues of dysmenorrheal symptom rats. Compared to normal rats, partial contents of the compounds in dysmenorrheal symptom rats׳ tissues at different time points had significant

  18. Opinion of the Consultative Committee for the EURATOM Research and Training Programme in the Field of Nuclear Energy (Fusion) - CCE-FU - on the European domestic assessment of the ITER-FEAT outline design report. Brussels, 11 July 2000

    International Nuclear Information System (INIS)

    2001-01-01

    The CCE-FU endorses the findings of the FTC on the European Domestic Assessment of the ITER-FEAT Outline Design Review, and expresses the opinion that: The machine, ITER-FEAT, the design of which is presented in the Outline Design Report and accompanying document (Technical Basis for the ITER-FEAT Outline Design) successfully responds, in broad terms, to the requirements set by the Special Working Group, established by the ITER Council, in response to Task No. 1 and adopted by the Council; The parameters chosen represent convergence towards a coherent design, based upon preserving adequate margins within the cost target against the new objectives and yet retaining flexibility to exploit advances in physics understanding; ITER-FEAT can meet its objectives of extended burn in induction operation with power amplification Q>10 at the reference operating values of Ip=15MA, Paux=40MW, thus providing 400 MW of fusion power. The margins to achieve this objective are in the range of 15-25%. The design also has sufficient flexibility to explore hybrid scenarios with long pulse capability (> 2000 seconds), and scenarios aiming at demonstrating steady state operation with the ratio of fusion power to input power for current drive of at least 5, provided further confinement enhancement can be achieved; Although most of the components of ITER-FEAT are still in a preliminary design state, the new design appears suitable to be developed into the final design stage, the new design appears suitable to be developed into the final design of a machine capable of achieving the objectives set by the ITER Council; The target cost for the realisation of ITER-FEAT was set by the ITER Council at about half of the 1998 ITER cost estimates. The present preliminary analysis provides confidence that this target will be reached. By the end of 2000, the detailed cost estimates will be provided from the detailed design specifications and manufacturing studies in the industries of the three Parties

  19. Phase II-trial of radiation therapy with 45 Gy, 5-fluorouracil (5-FU) and mitomycin C (MMC) in patients with anal cancer - a rationale to add regional hyperthermia?

    International Nuclear Information System (INIS)

    Graf, R.; Wust, P.; Gellermann, J.; Mohr, B.; Goegler, H.; Riess, H.; Felix, R.

    1996-01-01

    Purpose: To evaluate the effect of standard regimen of chemoradiation for anal cancer with a radiation dose of 45 Gy on survival, local control and toxicity with respect to the discussion about intensification of therapy. Assessment of prognostic factors and designing improved treatment strategies for certain risk groups. Materials and Methods: From 1987 to 1995 46 patients with localized anal cancer were eligible. Thirty-five women and 11 men with a median age of 54 years were treated according to the protocoll. Thirty-two (70%) patients had histologically a squamous cell carcinoma, 12 (26%) a cloacogenic carcinoma. Thirty-one patients (68%) had T1, T2 tumors, 15 patients (33%) had locally advanced primary tumors (T3, T4), 9 patients (20%) had N1-3 disease. Radiotherapy consisted of 30 Gy to the primary tumor and pelvic lymph nodes, followed by one week treatment break and boost to the primary tumor to a total dose of 45 Gy with a single dose of 2 Gy, mean duration of radiotherapy 44 days. 5-FU was given on days 1-5 and 29-33 as continuous infusion (800 mg/m 2 /day), MMC (10 mg/m 2 ) was given intravenously as bolus on day 1 and 29. Patients were followed for survival and local control. Toxicity was assessed using Common Toxicity Criteria and the LENT score (late effects normal tissues). The mean follow-up time was 34,4 months. Results: The cancer specific actuarial 5-year survival rate was 69%: 79% in T1, T2 and 41% in T3, T4 tumors (p = 0,03). The 5-year actuarial local control rate was 74%: 89% in T1, T2 tumors, 42% ind T3, T4 tumors (p 5 cm): p 4 cm): p = 0,04, depth of infiltration: p < 0,00, response: p < 0,00. No local control was achievable for tumors greater than 6 cm, whereas all local failures occurred when there was extrasphincteric infiltration. Conclusions: Colostomy-free survival was unsatisfactory. Depth of infiltration (extrasphincteric involvement) as well as tumor size (≥ 5 cm) has been shown as negative prognostic factor for local control

  20. Bruce Lee vs. Fu Manchu: Kung Fu Films and Asian American Stereotypes in America.

    Science.gov (United States)

    Farquhar, Judith; Doi, Mary L.

    1978-01-01

    Discussed in this article are numerous films which feature Asian characters and the influence these films have on stereotyped images of Asians and prevailing racist attitudes toward Asian Americans. (EB)

  1. Using Information-Sharing Exchange Techniques from the Private Sector to Enhance Information Sharing Between Domestic Intelligence Organizations

    Science.gov (United States)

    2013-12-01

    Travel Alliance —Fast Res System Flow (From Open Travel, 2009a...Intelligence Center THN Tourism Harmonisation Network VCC Virtual Command Center xiii ACKNOWLEDGMENTS I would like to open with thanking my wife...HSIN) The HSIN brand is divided into two parts, HSIN and HSIN-Intel. The larger HSIN is devoted to information sharing amongst the public safety

  2. Disrupted by violence: children's well-being and families' economic, social, and cultural capital in Ciudad Juarez, Mexico Perturbación del bienestar de los niños y del capital económico, social y cultural de las familias debido a la violencia en Ciudad Juárez, México

    Directory of Open Access Journals (Sweden)

    Alma A. Hernandez

    2012-05-01

    Full Text Available Since 2008, Ciudad Juarez (Chihuahua, Mexico has been undergoing a wave of violence due to a drug war, making the city a difficult environment in which to raise a family. This study uses qualitative methodology that incorporates 16 in-depth interviews with parents of children ages 0-5 years and 9 sets of photos from a subset of interviewed parents. The study explores how families' economic, social, and cultural capital has been disrupted by the violence and how it affects children's well-being. Social and economic capital declined significantly because of the violence as families experienced crime, had increased difficulty finding and maintaining employment, and decreased their interactions outside the home. Interviews also suggested that opportunities to gain cultural capital decreased because of this isolation. Understanding the detrimental effects of violence on families' capital can contribute to understanding children's well-being in violence-stricken communities.Desde el 2008, Ciudad Juárez (Chihuahua, México ha experimentado una ola de violencia debida a una guerra entre narcotraficantes, que convirtió a la ciudad en un entorno difícil para criar una familia. En este estudio se usó una metodología cualitativa que comprendió 16 entrevistas exhaustivas con padres de niños de 0 a 5 años y 9 grupos de fotos de un subconjunto de padres entrevistados. El estudio explora cómo el capital económico, social y cultural de las familias ha sido perturbado por la violencia y cómo se ve afectado el bienestar de los niños. El capital social y económico ha disminuido significativamente a causa de la violencia debido a que las familias experimentaron la criminalidad, tuvieron dificultades crecientes para encontrar y conservar el empleo y redujeron sus interacciones fuera del hogar. Las entrevistas también indicaron que las oportunidades de mejorar el capital cultural disminuyeron debido a este aislamiento. La comprensión de los efectos

  3. Sindromi prenaprezanja u području koljena

    OpenAIRE

    Pećina, Marko; Bojanić, Ivan; Hašpl, Miroslav

    2002-01-01

    Koljenski zglob sudjeluje praktički u svim aktivnostima pri radu i sportu (hodanje, trčanje, skakanje, udaranje nogom, klečanje, čučanje, penjanje). Oko koljenskog zgloba nalazi se mnogo hvatišta tetiva i mnogo sluznih vreća, a u cjelinu zgloba pripada i posebno građeni patelofemoralni zglob. Stoga ne začuđuje što se u koljenskom zglobu i oko njega često pojavljuju mikrotraumatska kumulirana oštećenja koja se manifestiraju ponajprije pojavom bolnih sindroma poznatih pod imenom sindroma prenap...

  4. Hogares y pobreza en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Germán VEGA-BRIONES

    2011-01-01

    Full Text Available La emigración de un solo miembro de la familia repercute en todo el hogar, esto se debe a que en un número considerable de casos, la esposa o algún otro miembro de la familia asume el rol de jefa(e del hogar, desarrollando actividades que anteriormente no efectuaba, como estar al frente y administrar los bienes, ordeñar ganado, pagar a empleados, etc., no obstante, como estrategia, el envío de remesas permite maximizar y diversificar las fuentes de ingreso del hogar. Partimos del supuesto de que la migración internacional constituye una estrategia, conciente y en la gran mayoría de los casos racional, y que por tanto, la recepción de remesas permite mejorar las condiciones de vida de sus miembros, lo que provoca cambios en la estructura y composición de los hogares y en las relaciones intrafamiliares.

  5. Robotika u neurorehabilitaciji: jučer, danas, sutra

    OpenAIRE

    SCHNURRER-LUKE-VRBANIĆ, Tea

    2016-01-01

    Robotika u neurorehabilitaciji osoba nakon moždanog udara ima svoje mjesto u rehabilitacijskom protokolu. Iako postoje različiti dizajni i vrste robota, dvije su osnovne grupe: egzoskeletni roboti, te roboti koji aktiviraju distalni, krajnji dio uda (od engl. end-effector robot). Obje vrste robota koriste se za rehabilitaciju hemiparetične ruke, te za rehabilitaciju hoda kod hemiparetične noge i oštećenja ravnoteže. Glavni cilj je robotom usmjerena vježba dostizanja zadataka...

  6. Jalakäijad aetakse ju alla / Leo Kunnas

    Index Scriptorium Estoniae

    Kunnas, Leo, 1967-

    2009-01-01

    Autori sõnul on ainus argument, millega idanaabri sõjalist juhtkonda veenda, sõjaaja relvajõud. Selleks on vaja tõestada, et suudame need vajaduse korral mobiliseerida, seda aga on võimalik teha suurõppuste korraldamisega

  7. Spoznanja na področju izbire strategij v podjetju

    Directory of Open Access Journals (Sweden)

    Sabina Veršič

    2017-06-01

    Full Text Available Research Question (RQ: What is the importance of strategic factors arising from a level of the company policy as well as the level of the strategic management? Purpose: The purpose of this research was to examine selected strategic factors and to determine importance of selected factors in strategy formulation process. Method: We made qualitative research, namely the study of a scientific literature. The emphasis is on research by foreign authors. Results: We found out which strategic factors are important in strategy formulation process. Authors attach great emphasis on factor strengths and weaknesses and also opportunities and threats of the company. Other important factors cited by the authors are the internal and external participants of the company, credibility, competitiveness, entrepreneurship, synergy, culture, philosophy, ethics, ecology and efficiency. Organization: Research is useful both, for future researches as well as practice (for top managers. In the field of strategy formulation process it is impossible to found research that is related on importance of strategic factors in strategy formulation process. The present research will be important tool in strategy formulation process. Society: The research refers to culture, ethics, values and company environment. Selected factors refers to the society, social responsibility and environment. We are explore the importance of the selected factors in strategy formulation process. Originality: Originality of the research is reflected in wide spectrum of strategic factors in the field of strategy planning. We did not find any research that considers such a wide spectrum of strategic factors. Limitations/Future Research: We restricted ourselves on strategic factors that derives from a level of the company policy and strategic management and on researches that has already been made. A suggestion for further research is quantitative research that will examine selected strategic factors and try to explain their influence on strategy formulation process.

  8. Original Article Moges Abay* *Psychology Dept. Educ. Faculty, JU ...

    African Journals Online (AJOL)

    dell

    about serious difficulties in laying the foundations for ... that impinges on his or her life and finally to his or ... The way teachers approach and communicate ..... learning their children were deaf was really a ..... cycle of primary school in selected.

  9. Semiconductor laser with fresh aloe shi fu and nursing therapy curative effect observation of indwelling needle phlebitis in patients with cerebral apoplexy%半导体激光联合鲜芦荟湿敷及护理治疗脑卒中患者留置针静脉炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王爱丽; 卢琦; 梅现红; 官莉

    2015-01-01

    Objective:To investigate the semiconductor laser combined fresh aloe shi fu and nursing treatment the curative effect of needle phlebitis in patients with cerebral apoplexy. Methods: 66 cases of patients with cerebral stroke with phlebitis, randomly divided into experimental group and the control group, 33 cases each. The control group was treated with fresh aloe shi fu; On the basis of the experimental group in the control group treatment using semiconduc﹣tor laser irradiation in vitro and nursing intervention in the treatment of phlebitis. On two groups before and after the treatment of phlebitis treatment efficient and subjective pain level. Results: The patients with phlebitis treatment effec﹣tive rate of 93. 94% , compared with control group effective rate was 81. 82% (P < 0. 05), the difference was statisti﹣cally significant. The experimental group patients with venous pain level compared with control group (P < 0. 05), the difference was statistically significant. Conclusion: The application of semiconductor laser with fresh aloe shi fu and nursing therapy in patients with cerebral apoplexy phlebitis, can alleviate the pain of the patients with cerebral apo﹣plexy.%探讨半导体激光照射联合鲜芦荟湿敷及护理治疗脑卒中患者留置针静脉炎的疗效。方法:将脑卒中并发静脉炎患者66例,随机分为实验组和对照组,各33例。对照组采用鲜芦荟湿敷方法治疗;实验组在对照组治疗的基础上采用半导体激光体外照射及护理干预治疗静脉炎。对两组治疗前后静脉炎治疗有效率及主观疼痛级别进行比较。结果:实验组患者静脉炎治疗有效率为93.94%,和对照组有效率81.82%相比(P<0.05),差别有统计学意义;实验组患者静脉疼痛级别和对照组相比(P<0.05),差别有统计学意义。结论:应用半导体激光照射联合鲜芦荟湿敷及护理治疗脑卒中患者静脉炎,能减轻脑卒中患者的痛苦。

  10. Temporary storage of jussara palm seeds: effects of time, temperature and pulp on germination and vigor Armazenamento temporário de sementes da palmeira juçara: efeitos do tempo, temperatura e polpa na germinação e vigor

    Directory of Open Access Journals (Sweden)

    Cibele C. Martins

    2004-06-01

    Full Text Available Seeds of jussara palm (Euterpe edulis Mart. are recalcitrant, presenting low longevity, high sensitivity to dehydration and to low temperatures of storage. Temperature conditions for temporary preservation of those seeds, with and without pulp, were studied. Mature fruits were harvested from 24 plants belonging to the palm collection of the Instituto Agronômico (IAC located at Ubatuba, São Paulo State, Brazil, and taken in moisture-proof containers to the Universidade Estadual de São Paulo, in Botucatu, São Paulo State. Half of the fruits were shelled and the seeds stored, with and without pulp, in sealed plastic bags (20 µm thick maintained in chambers with temperatures of 5; 10; 15 and 20-30ºC. Samples for the quality tests were taken at 0; 3; 6; 9 and 12 days after fruit harvest. Seeds stored with pulp were immediately shelled before test installation. Several characteristics were evaluated, especially seed water content, germination rate, seedling length and dry matter. There is a positive after-ripening effect on Euterpe edulis seeds. A period of storage of 9 to 12 days, after fruit harvest and before sowing, favored germination and vigor of jussara seeds. These effects were higher in shelled seeds when compared to unshelled ones. Short-term storage temperatures ranging from 5 to 20-30ºC are equally adequate for the preservation of seeds without pulp, but should not exceed 20ºC for those with pulp, since a decrease in germination and vigor, and an increase in rotted germinative button and dead seeds were observed at 20-30ºC temperature.As sementes da palmeira juçara (Euterpe edulis Mart. são recalcitrantes, apresentando baixa longevidade e sensibilidade à desidratação e ao armazenamento em temperaturas baixas. Neste trabalho foram estudadas condições de temperatura mais adequadas ao armazenamento temporário destas sementes com e sem a polpa. Frutos maduros foram colhidos em 24 plantas provenientes da coleção de palmeiras

  11. Morbilidad infantil por causas respiratorias y su relación con la contaminación atmosférica en Ciudad Juárez, Chihuahua, México Infant morbidity caused by respiratory diseases and its relation with the air pollution in Juarez City, Chihuahua, Mexico

    Directory of Open Access Journals (Sweden)

    Leticia Hernández-Cadena

    2007-02-01

    Full Text Available OBJETIVO: Evaluar el impacto de los contaminantes atmosféricos sobre la salud respiratoria de la población infantil de Ciudad Juárez, Chihuahua, México, considerando diferentes grupos etáreos. MATERIAL Y MÉTODOS: Se obtuvieron datos sobre consultas a urgencias de hospitales por afecciones de vías respiratorias altas, bajas y asma, en unidades del IMSS, de niños menores de 17 años de edad entre 1997 y 2001, y se estratificó por grupos etáreos (5 años. Se obtuvieron datos diarios sobre contaminantes aéreos (Ozono y PM10 y condiciones meteorológicas de la Red de Monitoreo en Ciudad Juárez. Para el análisis estadístico de los datos, se utilizó un Modelo Aditivo Generalizado, asumiendo una distribución de Poisson. RESULTADOS: Las concentraciones de ozono, pero no de PM10, se asociaron significativamente con las consultas a urgencias por afecciones respiratorias, principalmente en niños de 5 años o menores. En este grupo, un incremento de 20 ppb en 1 hr máxima de ozono se asociaron con un incremento de 8.3% en las consultas por afecciones de vías respiratorias superiores, con un retraso en la exposición de tres días, y un incremento de 12.7% en las consultas por infecciones de las vías respiratorias inferiores cuando se consideró un retraso de cuatro días en la exposición en el promedio móvil máximo de ocho horas. El efecto mayor para la muestra total, al igual que para el grupo de niños de 6 a 16 años, se observó en el retraso de tres días (5.1% para un aumento de 20 ppb en un máximo de una hora. Para este grupo no se observó un efecto significativo entre los niveles ambientales de ozono y el riesgo de contraer enfermedades de las vías respiratorias inferiores. CONCLUSIÓN: La amplitud del riesgo es de suma importancia, ya que puede representar un incremento en los costos de atención en el sistema de salud y la sociedad en general. Nuestros resultados destacan la necesidad de instrumentar acciones preventivas y

  12. Research on the Construction and Practice of the Operation Mechanism of University-Enterprise Strategic Alliance: Taking FuJian University of Technology as Example%校企战略联盟运行机制构建与实证分析——以福建工程学院为例

    Institute of Scientific and Technical Information of China (English)

    陈国铁; 张建勋

    2012-01-01

    以战略联盟思想建构校企合作运行机制,是培养应用型人才和优化地区产业结构,促进地区经济发展的需要。在引入战略联盟理论的基础上,研究了校企战略联盟的主要内容,探索了校企联盟的运行机制构建,并以福建工程学院为实证,展示了校企战略联盟的成效与前景。%Establishing the operation mechanism of university-enterprise strategic alliance based on strategic alliance ideas,is the need of training application-oriented personnel,optimizing the structure of regional industrial structure,and promoting regional economic development.Based on the strategic alliance theory,studies the main contents of university-enterprise strategic alliance,explores the construction of operation mechanism,and shows the effect and prospect with the practice of FuJian University of Technology.

  13. Da experiência estético-teleológica da natureza à consciência ecológica: uma leitura da Crítica do Juízo de Kant From aesthetic experience and teleological appreciation of nature to the ecological consciousness: Reading Kant's Critique of Judgment

    Directory of Open Access Journals (Sweden)

    Leonel Ribeiro dos Santos

    2006-01-01

    Full Text Available O objetivo deste ensaio é propor uma interpretação daquilo que para muitos intérpretes constitui o enigma e a dificuldade maior da terceira Crítica de Kant: o fato de o filósofo remeter para a mesma faculdade do espírito (a faculdade de julgar - Urteilskraft e para o mesmo princípio transcendental de apreciação (a teleoformidade ou conformidade a fins - Zweckmässigkeit o fenômeno da arte humana e os fenômenos da natureza organizada - a estética e a teleologia. Na leitura que propomos, tentamos perceber a fecundidade dessa estranha associação ("associação barroca", no dizer de Schopenhauer precisamente para permitir pensar alguns dos problemas que coloca atualmente a racionalidade ecológica, não aquela que visa excluir o homem da natureza como seu inimigo, mas uma consciência ecológica que defenda uma natureza viva com homens sensíveis, com seres humanos tais que não pensam já a sua relação com a natureza como sendo uma relação de meros "senhores e possuidores" frente a um objeto inerte e destituído de valor e de significação por si mesmo, mas que são capazes de contemplar e apreciar a natureza como valiosa por si mesma, de reconhecê-la como um sistema de sistemas finalizados e de colaborar na sua preservação, que têm até perante ela genuínos sentimentos de admiração pela sua beleza, de respeito pela sua sublimidade e de gratidão pela sua exuberância e favores. Em suma, propomo-nos mostrar a nova atitude perante a natureza que se deixa pensar a partir da Crítica do Juízo, considerada esta obra na sua complexidade sistemática.The aim of this paper is to suggest how the kantian conception of aesthetic experience of nature can illuminate some demands posed by the actual ecological consciousness. Main topics of our exposition would be the reversible analogy Kant supposes between art and nature, the kantian concept of a "technic of nature", the recognised priority of aesthetic experience of natural beauty

  14. The Fu Foundation School of Engineering & Applied Science - Columbia

    Science.gov (United States)

    Engineering Mechanics Computer Science Earth and Environmental Engineering Electrical Engineering Industrial Engineering & Applied Science - Columbia University Admissions Undergraduates Graduates Distance Learning Physics and Applied Mathematics Biomedical Engineering Chemical Engineering Civil Engineering and

  15. SYNTHESES, STRUCTURES AND PROPERTIES Jian Wu1*, Fu

    African Journals Online (AJOL)

    Preferred Customer

    Printed in Ethiopia. © 2014 Chemical Society of Ethiopia ... 1Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi University ... The O–H···O and C–H···Cl hydrogen-bonding interactions play a significant role in.

  16. Blickverhalten bei Abseitsentscheidungen im Fußball : Eine Feldstudie

    NARCIS (Netherlands)

    Schnyder, Urs; Koedijker, Johan M.; Kredel, Ralf; Hossner, Ernst Joachim

    2017-01-01

    The current study aims to determine the relationship between gaze characteristics and decision-making of expert and near-expert assistant referees in judging offside in football. Six assistant referees with different levels of expertise judged set-played offside scenes on the football field, while

  17. Kung fu-film alustas 15 000 vaatajaga

    Index Scriptorium Estoniae

    2006-01-01

    Soome ja Hiina mütoloogiat ühendav fantaasiafilm "Igavese armastuse sõdalane - Jade Warrior" (Soome, Hiina ja Eesti ühistöö) kogus Soome kinolevis avanädalavahetusel suhteliselt tagasihoidliku kassa

  18. Soome-ugri kung fu / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2006-01-01

    Soome ja Hiina mütoloogiat ühendav fantaasiafilm "Igavese armastuse sõdalane - Jade Warrior" (Soome, Hiina, Hollandi ja Eesti ühistöö) : stsenarist Iiro Küttner : režissöör Antti-Jussi Annila. Eestipoole produtsent Margus Õunapuu Eesti osast filmis

  19. 75 FR 62716 - Airworthiness Directives; Pacific Aerospace Limited Model FU24-954 and FU24A-954 Airplanes

    Science.gov (United States)

    2010-10-13

    ... new airworthiness directive (AD) for the products listed above that would supersede two existing ADs... aviation authority of another country to identify and correct an unsafe condition on an aviation product... failsafe structure. The Civil Aviation Authority (CAA), which is the aviation authority for New Zealand...

  20. Conciencia moral: ampliando su aplicación en salud. Aspectos teóricos y prácticos de los juicios de conciencia en Chile Consciência moral: ampliando sua aplicação em saúde. Aspectos teóricos e práticos dos juízos de consciência no país Moral conscience: widening its application in health. Theoretical and practical issues of moral judgment in Chile

    Directory of Open Access Journals (Sweden)

    Antonieta Valderrama Sandoval

    2011-11-01

    Full Text Available La conciencia se entiende habitualmente como un aspecto individual y subjetivo del ser humano; sin embargo, recientemente se ha destacado su carácter racional y sujeto a criterios externos de evaluación. La aplicación de los juicios de la conciencia moral es transversal a todos los campos de la atención en salud, incluso en la relación cotidiana con los pacientes. La objeción de conciencia de los profesionales de la salud ha sido criticada porque podría faltar a la responsabilidad profesional; no obstante, seguir la conciencia recta es una obligación moral para todos, independiente del rol que se cumpla en un determinado momento. Impedir hacerlo es lesionar la autonomía e integridad moral de quien busca actuar en conciencia.A consciência é entendida habitualmente como um aspecto individual e subjetivo do ser humano; entretanto, recentemente se tem destacado seu caráter racional e sujeito a critérios externos de avaliação. A aplicação dos juízos da consciência moral é transversal a todos os campos da atenção em saúde, inclusive na relação cotidiana com os pacientes. A objeção de consciência dos profissionais de saúde tem sido criticada porque esta poderia faltar com a responsabilidade profissional; não obstante, seguir a consciência reta é uma obrigação moral para todos, independente do papel que se cumpra num determinado momento. Impedir fazê-lo é lesar a autonomia e a integridade moral de quem busca atuar com consciência.Generally, conscience is understood as an individual and subjective character of human being; nevertheless, recently its rational character has been highlighted and subjected to external evaluation criteria. The application of moral conscience judgments is transversal to all health care fields, even in daily relations with patients. Health care professionals conscience objection has been criticized because it could neglect professional responsibility; nevertheless, to follow an honest

  1. Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis

    OpenAIRE

    Hou, Yi-Chou; Lin, Yen-Ju; Lu, Kuo-Cheng; Chiang, Han-Sun; Chang, Chia-Chi; Yang, Li-King

    2017-01-01

    Yi-Chou Hou,1 Yen-Ju Lin,2 Kuo-Cheng Lu,1 Han-Sun Chiang,3 Chia-Chi Chang,4 Li-King Yang1 1Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 2Department of Nursing, Taipei Medical University, 3Graduate Institute of Basic Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, 4School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, Republic of China Background:...

  2. ZAGOTAVLJANJE DOSEGLJIVOSTI V OMREŽJU VOIP S POMOČJO TELEFONSKE CENTRALE ASTERISK

    OpenAIRE

    Vitez, Matej

    2011-01-01

    V diplomskem delu opisujemo razvoj sistema za zagotavljanje dosegljivosti. Sistem temelji na telefonski centrali Asterisk, v povezavi s podatkovno bazo PostgreSql in spletno storitvijo. Sistem omogoča zaposlenim v podjetju večjo dosegljivost za stranke. Uporabniki sistema za zagotavljanje dosegljivosti si lahko preko spletne storitve ogledajo podatke o klici, poslušajo glasovna sporočila, vpisujejo dogodke v koledar, katerim dodajo parametre, ki se navezujejo na dosegljivost v času dogodka. P...

  3. El impuesto predial en Ciudad Juárez desde una perspectiva de equidad

    OpenAIRE

    Sergio Peña-Medina

    2016-01-01

    El aspecto de equidad en el impuesto predial es un tema relevante que se aborda en este artículo. Ésta se diferencia entre vertical y horizontal; la primera se refiere a un enfoque progresivo en donde aquellas propiedades que valen más pagan una tasa superior a las de menor valor; la equidad horizontal apunta a un tema de valuación y, en ella, las propiedades comparables pagan la misma tasa. El artículo tiene como objetivo poner a prueba la hipótesis de regresividad del impuesto predial; se a...

  4. El impuesto predial en Ciudad Juárez desde una perspectiva de equidad

    OpenAIRE

    Peña-Medina, Sergio

    2016-01-01

    Resumen: El aspecto de equidad en el impuesto predial es un tema relevante que se aborda en este artículo. Ésta se diferencia entre vertical y horizontal; la primera se refiere a un enfoque progresivo en donde aquellas propiedades que valen más pagan una tasa superior a las de menor valor; la equidad horizontal apunta a un tema de valuación y, en ella, las propiedades comparables pagan la misma tasa. El artículo tiene como objetivo poner a prueba la hipótesis de regresividad del impuesto pred...

  5. R-ES-ONANCE--I-Ju-ne--2-0-06------------~~~~----------------------------3

    Indian Academy of Sciences (India)

    study physics, his first choice, and instead he read metallurgy at the University of ... also led his wife to write a renowned historical book about the atomic scientists' movement, A Peril and ... Institute at the famous Harvard University. From 1962 ...

  6. The Completeness Theorem of G6del -R-ES-ONANCE--I-JU-IY

    Indian Academy of Sciences (India)

    logical deduction precise. This is best done by using an artificial language. We now proceed to define. a class of artificial languages, known as first order languages, which have sufficiently high expressive power. Such languages contain 'vari- ables' x, y, etc., for generic representation of objects or individuals of our study.

  7. Proektirovanie dorog v Grenlandii s pomoŝ’ju GIS-tehnologij

    DEFF Research Database (Denmark)

    Abdel, Barten

    2014-01-01

    Designing roads in the Arctic (Greenland ) and stretches 157 km between the towns of Sisimiut and Kangerlussuaq carried out in difficult climatic and geotechnical conditions in the presence of permafrost , which required in-depth analysis and research. For the design of the road in Greenland were...

  8. Testemunho, juízo político e história

    Directory of Open Access Journals (Sweden)

    Fernando Kolleritz

    2004-01-01

    Full Text Available A partir de um comentário sobre as propriedades características do gênero testemunhal, descrevem-se as respectivas situações ideológicas que presidiram à recepção de depoimentos sobre os campos de concentração nazistas e comunistas quando da sua publicação no Ocidente. Ao sublinhar a dimensão moral do testemunho e mostrar que os saberes dele advindos baseiam-se em práticas de reconhecimento, aponta-se, complementarmente, para situações em que o historiador vê-se por ele interpelado. Situações em que sua arte depende unicamente do ouvido que prestar ao apelo testemunhal. Nesse momento o testemunho não é mais fonte, pode tornar-se algo como um ultimato. Permutadas, assim, as posições, não fica o historiador exposto ao testemunho, carregando a inteira responsabilidade de sua audiência? Não deve o cultor de Clio a certos endereçamentos, por lacunares e subjetivos que sejam?We will underline the moral dimension of testimonies and try to show that the knowledge that issues of it is based on practical recognition. I will approach a peculiar type of deposition, that reconstructs repressive practices of totalitarian societies, in particular the Communists societies. Thanks to its remissive and evocative effectiveness the testimonial narratives hold a proper way to approach ethical questions that leave a sample of the totalitarian logic. Therefore the testimonial expression (and its fictional parallels will not be used mainly in the quality of historical source, but as principle and bedding for a political judgment. It is thus the question: what owes the historian to testimony? Doesn't the servant of Clio stay exposed to it?

  9. MARIJANSKA PUČKA BLAGDANSKA IMENA NA DUBROVAČKOM PODRUČJU

    OpenAIRE

    Vulić, Sanja

    2009-01-01

    U radu se opisuju pučka imena blagdana Gospe Karmelske, Gospe od Anđela, Gospina Pohoda sv. Elizabeti, Gospe od Krunice, Gospe Snježne, Gospe od Zdravlja, Gospe Lurdske, Gospe Fatimske, Imena Marijina, Gospe od Sedam Žalosti, Bezgrješnoga Začeća, Velike Gospe, Male Gospe i nekih lokalnih svetkovina. Uglavnom se razmatraju pučka blagdanska imena koja sam prikupila osobnim terenskim istraživanjem u samom gradu Dubrovniku, u Postranju u Župi dubrovačkoj, u Trpnju i Orebiću na Pelješcu te na otok...

  10. OGLAŠEVANJE NA SOCIALNEM OMREŽJU FACEBOOK, NA PRIMERU SPLETICNA.SI

    OpenAIRE

    Reisman, Nina

    2011-01-01

    Internet je od svojega razvoja dolgo časa obstajal kot prostor za enostransko komunikacijo. Isto se je dogajalo na televiziji, radiu in časopisih, kjer je javnost sprejemala informacije, ki jih je nekdo pripravil. Tradicionalni mediji so hitro doumeli, da takšna vrsta komunikacije ni naravna in ne predstavlja najboljšega ohranjanja gledalcev in poslušalcev. Začela se je uporabljati dvosmerna komunikacija. Trenutno v svetu najbolje poznan primer dvosmerne komunikacije je socialno omrežje F...

  11. Kwang Ju AB, Korea, Revised Uniform Summary of Surface Weather Observations (RUSSWO) Parts A, C - F.

    Science.gov (United States)

    1981-07-01

    66-69,73-80 NCV *TAYI Oft *vflA s.# VE yAR* MOflfl PERCENTAGE FREQUENCY OF OCCUR RENCE ALL (FROM HOURLY OBSERVATIONS) VISIBSLOY STATUTE MILES _ O > 6...698 680 2101 IN 932F IN a6?F a] 73O P ,0 P Toe, Im D’y 161b 95356S 251091 36.8 6686 683 28059- I.6 . Web 842579 235211 34.6 69535 680 39.81 9

  12. Programmatūras testētāju sertifikācija

    OpenAIRE

    Ambrasa, Aija

    2007-01-01

    Darba merkis ir atvieglot programmaturas testetaju sertifikacijas ieviešanu Latvija. Darba ir izpetitas sertificešanas iespejas visa pasaule, salidzinatas 3 popularakas sertifikacijas shemas, iepazistinats ar Starptautisko Programmaturas Testešanas Padomes piedavato programmu, kurai ši gada aprili pievienojas Latvija. Lai atvieglotu sertificešanas uzsakšanu Latvija, tika izveidota hrestomatija, jautajumu kopa, testešanas pamata terminu vardnica un ieteikumi, kadi butu janem ver...

  13. Ocena sestojne zgradbe na območju Krakovskega pragozdnega rezervata s segmentacijo podatkov laserskega skeniranja

    OpenAIRE

    Hladnik, David; Pintar, Anže Martin

    2017-01-01

    In Krakovo virgin forest reserve we assessed stand structures on the basis of the laser scanning data of Slovenia and forest inventory permanent sampling plots. Large growing stocks (730 m3 /ha) and quantities of deadwood (27 % of growing stock) are characteristic for a reserve in the area of lowland, occasionally flooded forests. Pedunculate oak (83 %) and common hornbeam (12 %) prevail in the growing stock. We delineated stand structures in the forest reserve zone on the basis of the height...

  14. reproductiva entre los adolescentes de Oaxaca de Juárez

    Directory of Open Access Journals (Sweden)

    Matthew C. Gutmann

    2005-01-01

    Full Text Available El presente trabajo explora la salud sexual adolescente en Oaxaca. Basado en un trabajo de campo etnográfico que se ha venido realizando desde el año 2001 sobre las sexualidades adolescentes, examina los sentidos de la iniciación sexual, las creencias tanto populares como biomédicas asociadas con la distinción entre sexualidades masculinas y femeninas, la naturalización de la sexualidad adolescente varonil en general y las implicaciones para la prevención y tratamiento del sida y otras infecciones transmitidas sexualmente. En particular, en este ensayo se comparan, por un lado, los discursos medicalizados relacionados a las nociones de la modernidad y la sexualidad y, por el otro, las ideas tan difundidas de las particularidades culturales de los varones adolescentes en México y en regiones específicas de Oaxaca. Los y las jóvenes en Oaxaca nacen dentro de sistemas ya establecidos de salud reproductiva, cortejo y sexualidades. Estos adolescentes entienden que sus sexualidades están limitadas por factores materiales y culturales e, incluso, por los discursos modernos sobre la sexualidad y las ideas falsas sobre los continuos viriles que establecen que los deseos y comportamientos sexuales son, naturalmente, diferentes entre los varones y las mujeres.

  15. Ju/'hoansi Adaptations to a Cash Economy | McCall | African ...

    African Journals Online (AJOL)

    African Sociological Review / Revue Africaine de Sociologie. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 4, No 1 (2000) >. Log in or Register to get access to full text downloads.

  16. abdu*', pa, wakawa2, am, sa'idu', l., and umohz, ju

    African Journals Online (AJOL)

    such as pigs and humans following concurrent infection ... Live-bird market, contaminated poultry houses and ... houses more than 100 days after the flock has been ... CLINICAL SIGNS. At present .... tests or viral nucleic acid using reverse ..... national emergency preparedness plan for .... influenza in caged laying chickens.

  17. Vzdrževanje likvidnosti kriptovalutnega trga v omrežju Ripple

    OpenAIRE

    BREZIGAR, JAKOB

    2017-01-01

    Vzdrževalec likvidnosti zagotavlja prodajalcem in kupcem finančnih inštrumentov nasprotno stranko pri sklepanju transakcij. Izvajanju nakupnega in prodajnega naročila hkrati pravimo vzdrževanje likvidnosti. Diplomsko delo obsega teoretično in praktično osnovo za izdelavo algoritma za samodejno vzdrževanje likvidnosti na enem izmed perspektivnih kriptovalutnih trgov Ripple. V diplomskem delu povzamemo teoretične osnove vzdrževanja likvidnosti, delovanje kriptovalutnega protokola Ripple in proc...

  18. Specialized Accounting Inspection: study on the perception of the Trial judges in the Labor Court System about the quality and relevance of the specialized investigation job of expertsPerícia Contábil: estudo da percepção de juízes de Primeira Instância na Justiça do Trabalho sobre a qualidade e a relevância do trabalho do peritoPericia Contable: estudio de la percepción de los jueces de Primera Instancia en el Tribunal del Trabajo sobre la calidad y la pertinencia de la labor del perito

    Directory of Open Access Journals (Sweden)

    NEVES JÚNIOR, Idalberto Jose das

    2013-06-01

    Full Text Available ABSTRACTThe court appointed experts have means to inform and elucidate the judge, guiding him in his decisions, since it can’t be expected that judges are scientists or technicians in all matters, since there are matters that need clarification and certification of professionals deserving full faith in all technical, moral, scientific and legal aspects. Thus, the burden shouldered by the Judge is shared with the Expert who instructs him with the certification of causes and events through his expertise and requirements of morality and honesty. Within this context, this study aimed to know the opinion of the Trial judges working in the Labour Court System on the quality and relevance of the work done by the accounting expert. To this end, we have carried out a field research with 135 Trial judges of the Labor Court System in all regions of Brazil. The multivariate statistical technique of cluster analysis was used to better study the cases. The results of this survey revealed that 58% of respondents regard the work of the expert accountant as good and necessary, and that 71% of the judges consider the work of the expert accountant relevant to support their decisions. However, the judges have shown the main failures found in the work of the accountant-expert as well as suggestions for improvement.RESUMOA perícia tem meios de cientificar e elucidar o julgador, orientando-o em suas decisões, uma vez que não se pode esperar que os magistrados sejam cientistas ou técnicos em quaisquer assuntos, visto que há matérias que precisam de esclarecimento e certificação de profissionais merecedores de inteira fé, nos aspectos técnicos, moral, científico e legal. Destarte, a carga que pesa sobre o Juiz é dividida com o Perito, que o instrui com a certificação de causas e fatos por meio de suas qualidades de especialista e requisitos de moralidade e honestidade. Dentro desse contexto, este estudo objetivou conhecer a opinião dos juízes que atuam

  19. Deputat Riigikogu v bojevike v stilje kung-fu / Alina Zelimhanova

    Index Scriptorium Estoniae

    Zelimhanova, Alina

    2005-01-01

    Soome ja Hiina mütoloogiat ühendava fantaasiafilmi "Armuvalus sõdalane" (eelarve ca 40 milj. krooni, tootjad Soome, Holland, Hiina ja Eesti) võtted algavad täna Vihterpalu rabas. Kaasa teeb ka Elle Kull, lavastab debütant AJ Annila

  20. Eesti teeb koos soomlaste ja hiinlastega kung-fu filmi / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2005-01-01

    Soome ja Hiina mütoloogiat ühendava fantaasiafilmi "Armuvalus sõdalane" (eelarve 39 milj. krooni) tootjad on Soome, Holland, Hiina ja Eesti (3,9 milj. krooni). Kaasa teeb ka Elle Kull, lavastab debütant AJ Annila

  1. Eestis algasid kung-fu-filmi võtted / Andri Maimets

    Index Scriptorium Estoniae

    Maimets, Andri, 1979-

    2005-01-01

    Soome ja Hiina mütoloogiat ühendava fantaasiafilmi "Armuvalus sõdalane" (eelarve ca 40 milj. krooni, tootjad Soome, Holland, Hiina ja Eesti) võtted algavad täna Vihterpalu rabas. Kaasa teeb ka Elle Kull, lavastab debütant AJ Annila

  2. Zugang zu neuen FuE-Konzepten durch innovative Verfahren der Pflanzenphänotypisierung

    Directory of Open Access Journals (Sweden)

    Altmann, Thomas

    2011-10-01

    Full Text Available The development and use of automated procedures of non- or minimal invasive monitoring of plant traits and features opens new opportunities for the identification of genetic factors determining plant characteristics and performance parameters, for the investigation of environmental effects on trait expression, for the selection of individuals or lines with preferred features from large populations, for the optimization of plant production systems, and for the recognition of novel uses of plants. This is achieved through development and application of precise and unbiased measurement procedures (not influenced by human perception, which (ideally are amenable to high-throughput approaches. They enable more accurate and much larger scale investigations or screenings than hitherto possible, they allow the detection of features that previously could not be assessed, and they offer access to monitoring and quantification of dynamic processes through repeated measurements over time. To this end, (novel sensor and detection systems have to be developed and an implemented, automation procedures have to be adapted and established, corresponding facilities have to be constructed and installed, which support monitoring and/or simulation of certain environmental parameters (in addition to the measurement of plant features and effective data analysis tools have to be developed and implemented.

  3. Giant planet migration during FU Orionis outbursts: 1D disc models

    Science.gov (United States)

    Dunhill, A. C.

    2018-05-01

    I present the results of semi-analytic calculations of migrating planets in young, outbursting circumstellar discs. Formed far out in the disc via gravitational fragmentation early on in its lifetime, these planets typically migrate at very slow rates and are therefore mostly expected to remain at large radii (such as is the case in HR 8799). I show that changes in the disc structure during FUor outbursts affect the planet's ability to maintain a gap and can allow a massive giant planet's semimajor axis to reduce by almost 5 per cent in a single outburst under the most optimistic conditions. Given that a single disc will likely undergo ˜10 such outbursts this process can significantly alter the expected radial distribution for GI-formed planets.

  4. Cardioprotective effects of Dan-Yang-Fu-Xin decoction on chronic ...

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research May 2016; 15 (5): 945-950 ... After intragastric administration for 8 weeks, several functional cardiac ... include the suppression of expression of inflammatory mediators and myocardial enzymes.

  5. Antropogenní transformace reliéfu v oblasti dolu Jeroným

    Czech Academy of Sciences Publication Activity Database

    Kirchner, Karel; Roštínský, Pavel

    2011-01-01

    Roč. 18, č. 1 (2011), s. 92-98 ISSN 1803-1447 R&D Projects: GA ČR GA105/09/0089 Institutional research plan: CEZ:AV0Z30860518 Keywords : geomorphology * anthropogenic transformation * Slavkovský les Forest Subject RIV: DE - Earth Magnetism, Geodesy, Geography www.caag.cz

  6. Investigation of compressive strength of concrete with slag and silica fu

    International Nuclear Information System (INIS)

    Mostofinejad, D.; Mirtalee, K.; Sadeghi, M.

    2002-01-01

    Without doubt, concrete has special place in construction of different types of structures, and used as one of the most important materials in construction industry. Today, with development and modernization of human knowledge in construction industry, it is possible to reach h igh performance concrete . Mechanical properties and durability of high performance concrete is quite better than that of conventional concrete. In present, the use of supplementary cementitious materials, mainly silica fume, fly ash and blast furnace slag has become increasingly common for reasons of economy and technical benefits imparted by these materials. The aim of present research is investigation and comparison compressive strength of concrete specimens due to variation of water to cementitious materials ratio (W/C M), silica fume and slag percent and their proportions as cement replacement. Furthermore, it is intended to determine best combination of these materials with cement in concrete (optimum percent) to reach to maximum compressive strength. In the current study, specimens were made in 0.5,0.4 and 0.3 W/C M ratio contained 0,20,35 and 50 percent of slag as cement replacement, where in each slag replacement percent, 0, 5, 10 and 15 percent of of silica fume were used as cement replacement. Results of the current study show that the combination effect of slag and silica fume replacement in concrete leads to the maximum compressive strength in concrete; also there are some optimum percents for replacement of slag and silica fume to cement to get the best results

  7. Die Fußnote über Geognosia in Humboldts Florae Fribergensis specimen

    Directory of Open Access Journals (Sweden)

    Herbert Pieper

    2007-04-01

    Full Text Available Article in German, Abstracts in English and GermanHumboldt distinguished between three disciplines dealing with the inquiring of the earth: geognosia, historia telluris, physiografia. In 1793, he used the notion of “Geognosie” for the first time. He explained the notion in a footnote that was reprinted in 1815, 1817, and again in 1845. The paper analyses the meaning attributed by Humboldt to the notion of “Geognosie” and gives a new German translation of the Latin texts of the footnote.

  8. Summary report of Japan-US joint project. JUPITER-II. FuY 2001 - 2006

    International Nuclear Information System (INIS)

    Abe, K.; Kohyama, A.; Tanaka, S.; Muroga, T.; Namba, C.; Sze, D.K.

    2008-03-01

    This report summarizes the scientific accomplishments achieved through the JUPITER-II Japan-US Collaboration Program. The JUPITER-II collaboration (Japan-USA Program of Irradiation/Integration Test for Fusion Research -II) has been carried out through six years (2001-2006) under Phase 4 of the collaboration implemented by Amendment 4 of Annex I to the MEXT (Ministry of Education, Culture, Sports, Science and Technology)-DOE (United States Department of Energy) Cooperation. This program followed the RTNS-II Program (Phase 1: 1982-1986), the FFTF/MOTA Program (Phase 2: 1987-1994) and the JUPITER Program (Phase 3: 1995-2000). The JUPITER-II collaboration was established to provide the scientific foundations for understanding the integrated behavior of blanket materials combinations operating under conditions characteristic of fusion reactors, including interactive neutron irradiation effects, high temperature coolant flow phenomena, heat and mass transport in blanket materials, and coolant chemistry and its interactions with surrounding materials. The scientific concept of this program is to study the key technology in macroscopic system integration for advanced blanket based on an understanding of the relevant mechanics at the microscopic level. The 44 of the presented papers are indexed individually. (J.P.N.)

  9. A Peer-Assessment Mobile Kung Fu Education Approach to Improving Students' Affective Performances

    Science.gov (United States)

    Kuo, Fon-Chu; Chen, Jun-Ming; Chu, Hui-Chun; Yang, Kai-Hsiang; Chen, Yi-Hsuan

    2017-01-01

    Peer-assessment and video comment-sharing are effective learning strategies for students to receive feedback on their learning. Researchers have emphasized the need for well-designed peer involvement in order to improve students' abilities in the cognitive and affective domains. Although student perceptions of peer-assessment have been studied…

  10. OF KUNG FU AND CHOCOLATES: A STRATEGIC NARRATIVE OF KATHY’S BUSINESS SOJOURN IN CHINA

    OpenAIRE

    Mason, Cordelia

    2013-01-01

    The remarkable growth of China in the last decade catapults it rapidly into one of the most prominent players in international business. Thus, it is not surprising that many studies have been undertaken to explore various business phenomena relating to China such as how Chinese companies explore global business opportunities and how companies from all over enter the Chinese market. A review of the literature shows that many of these studies focus on corporations and SMEs (Yang and Lee, 2002, ...

  11. γ-Rays Radiation of High Redshift Fermi Blazars WG Liu1, SH Fu2 ...

    Indian Academy of Sciences (India)

    FSRQs), which is from the second Fermi-LAT AGNs catalogue. (2LAC), we studied the correlation between flux densities (FR,FK,Fγ ) in the radio, infrared and γ-ray wave bands. We found that there is a significant positive correlation between Fγ ...

  12. *J.S., Ogeh and E. Ukodo Fu ll L eng th R esearch A rticle

    African Journals Online (AJOL)

    Results showed that BL had the highest organic carbon content with a range values of (6.00 – 30.30g/kg ) and. US had the lowest organic carbon ... forest or agricultural field, soil properties vary from the summit of a hill down to the bottom slope. ..... crop production in five ecological zones of. Western Nigeria. Proceedings of ...

  13. Segmentacija trga in spremembe na področju nizkocenovnih hotelov na mestnih območjih Južnoafriške republike: Market segmentation and the changing budget hotel industry in urban South Africa:

    OpenAIRE

    Rogerson, Jayne M.

    2013-01-01

    Market segmentation is a critical driver of change in the hotel industry, resulting in the appearance of differentiated forms of hotel property developments, including budget hotels. International research on budget hotels is mainly limited to North America and Europe, with some more recent studies on emerging economies. This article examines the role of budget hotels within the wider restructuring of the South African hotel industry following the country's re-entry into the global tourism ec...

  14. Pregled istraživanja o obrazovanju u području marketinške etike

    OpenAIRE

    Hrehová, Daniela; Žiaran, Pavel

    2016-01-01

    Purpose – Last two decades have seen a marked increase in the interest given to the field of business ethics, particularly, marketing ethics. Marketing ethics provides an innumerable amount of materials and topics for open discussion, as well as for application in practice. Our intention is to open up a space within which to promote timely debate on contemporary marketing education. Design/Methodology/Approach – Monitoring of academic journals in the area of marketing ethics tuition acces...

  15. Literatura consolatoria en torno a la muerte del príncipe don Juán

    Directory of Open Access Journals (Sweden)

    Jacobo SANZ HERMIDA

    2009-12-01

    Full Text Available Se lamentaba Juan del Encina haciéndose eco del dolor que asoló a España tras la muerte del príncipe don Juan, primogénito de los Reyes Católicos: «Fortuna nos traxo tal pena penosa/ que ágenos nos hizo de toda holganca./ Secóse la flor de nuestra esperanca,/ gran fruto esperando de planta graciosa:/ nacieron espinas; secóse la rosa;/ secóse la flor; nacieron abrojos;/ nacieron fatigas, nacieron enojos./ Murió nuestro Príncipe, joya preciosa».

  16. Secagem e armazenamento de sementes de juçara Drying and storage of euterpe edulis seeds

    Directory of Open Access Journals (Sweden)

    Cibele Chalita Martins

    2009-08-01

    Full Text Available Com o objetivo de verificar o efeito da secagem parcial e do armazenamento sobre a germinação e vigor de sementes de Euterpe edulis obtidas em três épocas de produção, o lote 1 foi colhido em 10 plantasmatriz (PM, em 02/99; o lote 2 em 15 PM, em 04/00; e o lote 3 em 11 PM, em 08/00. Os frutos foram despolpados e as sementes, colocadas para secar por zero, 20 e 40 h (três sublotes, em câmara seca (temperatura de 27 ºC e umidade relativa de 35%. Os três sublotes foram armazenados a 10 ºC, em sacos plásticos (20 mm de espessura fechados. Durante o armazenamento, a qualidade das sementes foi avaliada a cada seis semanas, por 30 semanas, por meio das seguintes determinações: teor de água (105±3 ºC/24 h, porcentagem de germinação e vigor (primeira contagem e índice de velocidade de germinação. O aumento do tempo de secagem resultou em sementes com teor de água decrescente, em torno de 14 a 21% dos valores iniciais, que se mantiveram praticamente inalterados durante o armazenamento. A germinação e vigor das sementes foram prejudicados pela secagem parcial e pelo aumento do tempo de armazenamento, de forma diferenciada entre as épocas de produção, e ambas as características dependem das condições climáticas vigentes durante o desenvolvimento e maturação das sementes.The objective of this research was to verify the effects of partial drying and storage duration on the germination and vigor of three E. edulis seed lots developed under different weather conditions. Mature fruits were harvested in the palm collection from the Instituto Agronômico, located in Ubatuba, SP., forming three seed lots. Seeds from ten plants were harvested on 02/99 and constituted the Seed lot 1; seed lot 2 was composed of seeds of fifteen plants collected in 04/00, whereas seeds from eleven plants harvested on 08/00 composed seed lot 3. The fruits were depulped and the seeds were dried for 0, 20 and 40 hours, using a drying chamber regulated at 27º C of temperature and 35% of relative humidity. The seeds were stored at 10º C, in closed plastic bags (20 mm thick. During storage, seed quality was evaluated every six weeks, using the following traits: seed water content (105±3ºC/24h, germination (% and vigor (first germination counting and index of the velocity of germination (IVG. Seed drying prior to storage decreased the seed water content in 14 - 21% of the initial values. Germination and vigor were hampered by partial drying and by the storage duration in a differential mode, and both traits depended on the climatic conditions observed during seed developing and maturation.

  17. Saa võimust : [luuletused] / J{u00E1nos Pilinszky ; tlk. Tiiu Kokla, Kairi Mesipuu

    Index Scriptorium Estoniae

    Pilinszky, J{u00E1nos

    2004-01-01

    Sisu: Saa võimust ; Trapets ja tõke ; Talvise taeva all ; Ühe kire marginaaliks ; Harbach 1944 ; Armastuse kõrb ; Apokrüüf ; Nelik ; Järelsõna ; Introitus ; Van Gogh ; Väike öömuusika ; Timuka päevikust ; Madalseisu pidu ; Pole muud ; Ravensbrücki passioon ; Van Goghi palve ; Kadunud poja otsimine ; Su käsi, mu käsi ; Salamõrv ; Luuletus ; Peks ; 22. detsember 1970 ; Visand ; Kolmandal päeval ; Kadunud pojad ; Lõpetamata minevik. Eluloolisi andmeid autori kohta lk. 181-182

  18. „Du ju spik ponglish”? O językowo-kulturowej hybrydzie XXI w. w wybranych przekazach popkultury

    Directory of Open Access Journals (Sweden)

    Mieszko Rozpędowski

    2015-11-01

    Full Text Available Analysis of the problem of bilingualism in polish language called „ponglish” – Polish-English media messages, music, television, advertising and fimowych. It is: 1 a natural connection in two foreign languages Polish and English, or 2 conscious media creation. This problem also concern of media education.

  19. Micromamiferos andinos holocenicos del sitio arqueologico Inca Cueva 5, Ju Juy, Argentina: tafonomia, zoogeografia y reconstruccion paleoambiental

    Directory of Open Access Journals (Sweden)

    Ortiz, P. E.

    2002-08-01

    Full Text Available A micromammal archaeological sequence (2120 f 120 to 780 f 100 years BP from Inca Cueva 5 site (23" 05' S - 65" 27' W; 3700 m.a.s.l., Jujuy Province, Argentina was studied. The following mammalian taxa were recorded: Order Didelphimorphia, Family Didelphidae, Thylamys cf. T. pallidior; Order Rodentia, Family Muridae, Akodon cf. A. albiventer, Andinomys edax, Auliscomys sublimis, Calomys lepidus, Neotomys ebriosus, Phyllotis sp.; Family Caviidae, Cavia cf. C. tschudii, Galea musteloides; Family Abrocomidae, Abrocoma cinerea; Family Chinchillidae, Lagidium viscacia; Family Octodontidae, Octodontomys gliroides. The taphonomy indicates that the sequence is an owl pellet accumulation inside the cave. The general landscape corresponds to the oriental border of the Puna steppe, with scattered shrub and low brush vegetation. Near the site there are small tree groups of Polylepis australis as well as small streams covered with grass and ciperaceous vegetation known as «vegas». Al1 the recorded taxa at Inca Cueva 5 exist today in Puna and Prepuna environments from Jujuy and Salta Provinces and southem Bolivia, excepting Cavia cf. C. tschudii. The modem records of this species in northem Argentina and southern Bolivia come from localities with high montane bunchgrass prairies and forests of the humid Yungas phytogeographical region. The presence of this species in the sequence suggests wetter climatic conditions on this region when the archaeological site was originated. Later drier conditions, caused probably by anthropic influence in the last 500 years, produced the retraction of Cavia tschudii to the moist eastern side of the Andes and its disappeareance of the Puna areas.El sitio arqueológico Inca Cueva 5 se encuentra en la provincia de Jujuy, Argentina, en el borde oriental de la región de la Puna (23" 05' S - 65" 27' W; 3700 m s n m y está fechado entre 2120 f 120 y 780 f 100 años radiocarbónicos AP. El estudio de una pequeña muestra de micromamíferos permitió reconocer la presencia de los siguientes taxa: Orden Didelphimorphia, Familia Didelphidae, Thylamys cf. T. pallidior; Orden Rodentia, Familia Muridae, Akodon cf. A. albiventer, Andinomys edax, Auliscomys sublimis, Calomys lepidus, Neotomys ebriosus, Phyllotis sp.; Familia Caviidae, Cavia cf. C. tschudii, Galea musteloides; Familia Abrocomidae, Abrocoma cinerea; Familia Chinchillidae, Lagidium viscacia; Familia Octodontidae, Octodontomys gliroides. La tafonomía indica que el agregado tuvo su origen en la depositación de egagrópilas de lechuza (Aves, Strigiformes en el contexto de la cueva. El ambiente general actual en la zona corresponde a la estepa puneña, con arbustos y matorrales bajos y dispersos. En el fondo del valle hay bosquecillos de Polylepis australis, un curso de agua y vegas pequeñas y circunscritas. Todas las especies registradas en Inca Cueva 5 habitan actualmente en ambientes de Puna y Prepuna de Salta, Jujuy y sur de Bolivia, a excepción de Cavia cf. C. tschudii. Los registros actuales de esta especie en el noroeste de Argentina y sur de Bolivia corresponden a localidades ubicadas en pastizales de altura y bosques subtropicales de Yungas. La presencia de este taxón en la secuencia sugiere condiciones de mayor humedad que las actuales para la región durante el lapso considerado. Condiciones posteriores de mayor aridez, probablemente asociadas al impacto antrópico de los últimos 500 años, habrían redundado en la desaparición de Cavia tschudii de áreas puneñas y en su retracción a los cordones orientales húmedos de los Andes.

  20. Micromamiferos andinos holocenicos del sitio arqueologico Inca Cueva 5, Ju Juy, Argentina: tafonomia, zoogeografia y reconstruccion paleoambiental

    OpenAIRE

    Ortiz, P. E.; Teta, P.

    2002-01-01

    A micromammal archaeological sequence (2120 f 120 to 780 f 100 years BP) from Inca Cueva 5 site (23" 05' S - 65" 27' W; 3700 m.a.s.l., Jujuy Province, Argentina) was studied. The following mammalian taxa were recorded: Order Didelphimorphia, Family Didelphidae, Thylamys cf. T. pallidior; Order Rodentia, Family Muridae, Akodon cf. A. albiventer, Andinomys edax, Auliscomys sublimis, Calomys lepidus, Neotomys ebriosus, Phyllotis sp.; Family Caviidae, Cavia cf. C. tschudii, Galea musteloides; Fam...

  1. Avaliação de fidedignidade entre juízes para os temas do CAT-A

    OpenAIRE

    Santos, Adriana Sylla Pereira

    2011-01-01

    A presente dissertação de Mestrado é composta por dois estudos, conforme as normas do Programa de Pós-Graduação em Psicologia da PUCRS. O primeiro estudo é uma revisão da literatura acerca do Teste de Apercepção Temática Infantil, intitulado História e Sistemas de Correção para o Teste de Apercepção Temática Infantil, buscando compreender os aspectos históricos, forma de aplicação, sistemas de correção e interpretação do teste, além de averiguar pesquisas referentes ao uso do instrumento no B...

  2. Discursos y narrativas sobre violencia, miedo e inseguridad en México : el caso Ciudad Juárez

    NARCIS (Netherlands)

    Balderas Domínguez, Jorge

    2012-01-01

    In recent years, Mexican society has been involved in a spiral of social violence. Most regions had not experienced such a level of violence since the revolutionary period in the early twentieth century, likewise for other parts of the country this social phenomenon has been totally unprecedented.

  3. Infanticidio y disciplina popular en el sistema ju dicial de Sonora, México entre 1855 y 1929

    Directory of Open Access Journals (Sweden)

    Laura Shelton

    2017-01-01

    Full Text Available El artículo explora por qué las comunidades locales en el estado de Sonora utilizaron la judicatura estatal en nuevas maneras para disciplinar a mujeres acusadas de infanticidio, aborto provocado y abandono infantil durante el porfiriato. Analiza los proce sos penales contra mujeres para descubrir los cambios en los sistemas de género y proponer que éstos contribuyeron al aumento de la vigilancia de la conducta sexual de las mujeres por las identidades masculinas de la época. Los juicios por infanticidio die ron pie a los discursos de inferioridad étnica, económica y de género hacia las mujeres, especialmente con las jóvenes que ocultaban sus embarazos. Concluye que los agentes estatales no se unificaron en su tratamiento de la delincuencia femenina, pero la p resión popular desempeñó un papel represivo en la expansión del poder del Estado para imponer el orden moral y asegurar un espacio para la vergüenza pública de la sexualidad femenina.

  4. Problematika trgovine z mladoletnimi osebami na območju Makedonije in sosednjih držav

    OpenAIRE

    Stefanovski, Kristijan

    2017-01-01

    Človek lahko normalno živi le, če je svoboden, medtem ko »nesvoboda« iz človeka naredi sužnja. Trgovina z ljudmi ali t. i sodobno suženjstvo v 21. stoletju počasi in zanesljivo postaja pereč problem sodobnega življenja. Ljudje se zaradi želje po hitrem zaslužku pogosto znajdejo na življenjski poti, ki je izpolnjena s strahom, trpljenjem, z grožnjami, bolečinami, s škodo, z negotovostjo itd. Trgovina z ljudmi predstavlja eno izmed najhujših kršitev človekovih pravic. Žrtvam namreč odvzame ...

  5. Nursing Ethics and the 21st-Century Armed Conflict: The Example of Ciudad Juárez.

    Science.gov (United States)

    O'Connor, Kathleen

    2017-01-01

    The purpose of this article is to call attention to the lack of caregiver safety in conflict settings; to bring awareness to nurses and health care professionals of new challenges, specifically the deliberate targeting of health care professionals, that they may encounter in local armed conflict situations; and to address a gap in knowledge about the social and cultural factors surrounding 21st-century armed conflict that directly affect the provision of health care. I argue that these are of interest to transcultural nursing in that violent actors belong to a dangerous subculture, the understanding of which is important to transcultural nursing practice and caregiver safety. The article calls for increased focus on the protection of the nursing workforce and renewed attention on international humanitarian law and the Geneva Conventions that mandate the safety of global health care workers. © The Author(s) 2015.

  6. The involvement of citizens and water management: Neighborhood committees leaders in Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Gustavo Córdova Bojórquez

    2005-07-01

    Full Text Available This paper seeks to analyze public participation in water management through a survey applied to the leaders of neighborhood committees in Ciudad Juarez, Chihuahua. As part of the methodology, two variables —external and internal influences— and fourteen indicators were utilized. Results show that neighborhood committees, as a public participation structure, are in crisis. The structure shows both internal and external signs of breaking up: there are no clear mechanisms of summons or participation, nor are there any adecuate mechanisms capable of articulating demands and government authority, insofar as external political agents have been allowed to participate in internal management and committee issues. For this reason, the capacity of local neighborhood committees to make decisions regarding city water management is placed in doubt.

  7. Generosidade versus interesse próprio: juízos morais de crianças e adolescentes

    Directory of Open Access Journals (Sweden)

    Liana Gama do Vale

    Full Text Available Este estudo investigou, em contexto psicogenético, que lugar a generosidade ocupa no universo moral de crianças e adolescentes em contraposição à satisfação de um interesse próprio. Foram entrevistados, individualmente, 30 alunos de uma escola pública de Vitória-ES, os quais foram divididos em três grupos de acordo com a faixa etária (7, 10 e 13 anos. Foi utilizada uma história-dilema que trazia um conflito entre a possibilidade de manifestar a generosidade e a oportunidade de satisfazer um interesse próprio. Em todas as faixas etárias pesquisadas, a maioria dos participantes optou pela generosidade em detrimento da satisfação do próprio interesse. A porcentagem dessa resposta na faixa etária de 10 anos, contudo, foi inferior às porcentagens nas demais idades estudadas. Pode-se afirmar, portanto, que a generosidade faz parte do universo moral infantil e adolescente. Este trabalho contribui para a expansão do campo de pesquisas sobre a moralidade e oferece importantes subsídios para propostas de educação moral que contemplem virtudes como a generosidade.

  8. ”Ja, det är ju de det handlar om, det är ju kommunikation, annars kan man ju låta bli.” : -en studie om kulturhistoriska museers syn på kommunikation i utställningssituationer

    OpenAIRE

    Eklund, Emma

    2008-01-01

    Purpose/Aim: Exhibitions in cultural-historical museums have traditionally been object-centered and associated with one-way communication. The aim of this thesis is to gain knowledge about how exhibition producers – and educationalists at swedish cultural-historical museums today relate to communication in exhibitions from a communication scientific perspective. Material/Method: The method of the thesis is interviews exhibition producers – and educationalists at five swedish cultural-historic...

  9. Helicobacter pylori infection is not associated with failure to thrive: a case–control study

    Directory of Open Access Journals (Sweden)

    Chiu NC

    2017-02-01

    Full Text Available Nan-Chang Chiu,1,2,* Chien-Yu Lin,3,* Hsin Chi,1 Chun-Yan Yeung,1,2 Wei-Hsin Ting,1 Wai-Tao Chan,1 Chuen-Bin Jiang,1 Sung-Tse Li,3,4 Chao-Hsu Lin,3 Hung-Chang Lee1,2 1Department of Pediatrics, MacKay Children’s Hospital, 2Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 3Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, 4Department of Statistics and Information Science, Fu Jen Catholic University, New Taipei, Taiwan *These authors contributed equally to this work Purpose: The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate the association between H. pylori infection and failure to thrive (FTT.Patients and methods: From January 2009 to December 2011, 53 children with FTT group and matched children with the same sex and age and similar socioeconomic status without FTT (control group were enrolled. A questionnaire was administered to the parents/guardian, and a 13C-urea breath test was performed to detect H. pylori infection.Results: We found that the total prevalence of H. pylori infection was 29.2% and that there was no association between FTT and H. pylori infection (FTT group: 32%; control group: 26.4%; P=0.67. Short stature was more common in the FTT group and abdominal pain in the control group (FTT group: 37.7%; control group: 11.3%; P=0.003. In a comparison between the H. pylori-positive and -negative groups, abdominal pain (87.1% vs 64%; P=0.032 and the frequency of endoscopy (74.2% vs 32%; P<0.001 were significantly more common in the H. pylori-positive group.Conclusion: We found that children with H. pylori infection are at an increased risk for abdominal pain and that FTT is not associated with H. pylori infection. The decision for eradication should be evaluated carefully and individualized. Keywords: Helicobacter pylori, 13C-urea breath test, failure

  10. 76 FR 384 - Certain Semiconductor Chips and Products Containing Same; Notice of Investigation

    Science.gov (United States)

    2011-01-04

    ... Industry, CA 91748. Biostar Microtech International Corp., 2 Fl., 108-2, Ming Chuan Road, Hsin Tien, Taiwan... Chiang Road, Hsin-Tien, Taipei 231, Taiwan. Gracom Technologies LLC, 1214 John Reed Ct., City of Industry.... Patent No. 7,715,494 (``the `494 patent''). The complaint further alleges that an industry in the United...

  11. Focal points of future FuE work concerning the final disposal of radioactive wastes (2011-2014); Schwerpunkte zukuenftiger FuE-Arbeiten bei der Endlagerung radioaktiver Abfaelle (2011-2014)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-15

    The present Federal support concept is the basis for applied fundamental research concerning final disposal of heat generating radioactive wastes. The use-oriented fundamental research is aimed to the development of a scientific-technical basis for the realization of a final repository for heat-generating radioactive wastes and spent nuclear fuel, to the continuous advancement of the state of science and technology with respect to final waste disposal and a substantial contribution to the constitution, development and preservation of scientific-technological competence in the field of nuclear waste management in Germany. The concept includes research and development work concerning final disposal in the host rock salt, clays and crystalline rocks (granite). The research and development main issues are the final disposal system, the system behavior, further topics in relation to final disposal and nuclear materials surveillance.

  12. Studien zur Eignung von Silizium Photomultipliern für den Einsatz im erweiterten CMS Detektor am SLHC

    CERN Document Server

    Rennefeld, Joerg

    2010-01-01

    Silicon photomultipliers (SiPMs) are modern semiconductor based detectors that have the potential to replace conventional photomultiplier tubes (PMTs) in many fields of application. In the course of research and development for upgrades of the CMS detector their potential for usage in different components is evaluated. The paper at hand deals with the temperature dependency of SiPMs. Their dark current is an important operating parameter. His temperature dependency is investigated using current-voltage characteristics. Furthermore a method for obtaining temperature independent output pulses is presented. To unleash the full potential of the sensors one has to make use of customized electronics for the readout. Therefore a custom printed circuit board developed by the electronics departments of our institute (III. Physikalisches Institut B, RWTH Aachen University) is used in this thesis. Finally the results of measurements on two commercially available MPPC modules from Hamamatsu Photonics K. K. are presented.

  13. Density measurements of H- and D- for fusion applications (final scientific report contract FU-CT-2000-50001)

    Energy Technology Data Exchange (ETDEWEB)

    Boilson, D

    2003-03-01

    The main topic of this contract is the implementation of the Cavity Ring-down Spectroscopy (CRS) technique proposed for quantitative measurement of negative H{sup -} and D{sup -} densities in the Kamaboko III ion source on the MANTIS test bed in the DRFC, CEA Cadarache. MANTIS is used for the development of high density negative ion current beams for use in NBI systems in proposed nuclear fusion reactors. The source used at the MANTIS test stand is a scale version of the source designed for the ITER neutral beam injection system called the Kamaboko III ion source. This report outlines the performance of the KAMABOKO source when operated in caseiated mode. The effect of plasma grid temperature, Cs seeding, Cs consumption, and long pulse, 1000 s, beam extraction are discussed, and the limitations observed with the MANTIS system are identified and further objectives outlined. (author)

  14. Focal points of future FuE work concerning the final disposal of radioactive wastes (2011-2014)

    International Nuclear Information System (INIS)

    2012-07-01

    The present Federal support concept is the basis for applied fundamental research concerning final disposal of heat generating radioactive wastes. The use-oriented fundamental research is aimed to the development of a scientific-technical basis for the realization of a final repository for heat-generating radioactive wastes and spent nuclear fuel, to the continuous advancement of the state of science and technology with respect to final waste disposal and a substantial contribution to the constitution, development and preservation of scientific-technological competence in the field of nuclear waste management in Germany. The concept includes research and development work concerning final disposal in the host rock salt, clays and crystalline rocks (granite). The research and development main issues are the final disposal system, the system behavior, further topics in relation to final disposal and nuclear materials surveillance.

  15. Tumor lysis syndrome in a patient with metastatic colon cancer after treatment with oxaliplatin and 5-Fu

    Directory of Open Access Journals (Sweden)

    Ruo-Han Tseng

    2016-12-01

    Full Text Available Tumor lysis syndrome in solid tumors is a rare occurrence, with a poor prognosis. We present the case of a patient of recurrent colon cancer who received chemotherapy with FOLFOX regimen (lencovorin, fluorouracil, and oxaliplatin with subsequent tumor lysis. We present a recurrent rectal cancer patient suffered from tumor lysis syndrome after salvage FOLFOX regimen. After treat with CVVH with improved conscious status. In this case report, we had review the tumor lysis in solid tumor.

  16. Altered characteristics of cancer stem/initiating cells in a breast cancer cell line treated with persistent 5-FU chemotherapy

    OpenAIRE

    LÜ, XINQUAN; DENG, QING; LI, HUIXIANG; SUO, ZHENHE

    2011-01-01

    Drug resistance of cancer stem/initiating cells has been considered to be one of the main reasons for tumor relapse. However, knowledge concerning the changes in stem/ initiating cells during chemotherapy is limited. In the present study, the breast cancer cell line MDA-MB-468 was cultured with 5-fluorouracil and serially passaged. Six cell generations were collected. Semi-quantitative RT-PCR and flow cytometric techniques were used to evaluate the protein and mRNA expression of stem/initiati...

  17. Leistungsvergleich und Emotionalität: Die mediale Präsentation von Fußball

    NARCIS (Netherlands)

    Stauff, M.

    2010-01-01

    With its plentiful displays of emotions, football participates in many fields of meaning. Television in particular creates clearly defined images of emotions; their status, however, is ambivalent: They contribute to very specific communications on sports, at the same time alluding to discourses and

  18. The Cornella Health Interview Survey Follow-Up (CHIS.FU Study: design, methods, and response rate

    Directory of Open Access Journals (Sweden)

    Perez Gloria

    2003-03-01

    Full Text Available Abstract Background The aim of this report is to describe the main characteristics of the design, including response rates, of the Cornella Health Interview Survey Follow-up Study. Methods The original cohort consisted of 2,500 subjects (1,263 women and 1,237 men interviewed as part of the 1994 Cornella Health Interview Study. A record linkage to update the address and vital status of the cohort members was carried out using, first a deterministic method, and secondly a probabilistic one, based on each subject's first name and surnames. Subsequently, we attempted to locate the cohort members to conduct the phone follow-up interviews. A pilot study was carried out to test the overall feasibility and to modify some procedures before the field work began. Results After record linkage, 2,468 (98.7% subjects were successfully traced. Of these, 91 (3.6% were deceased, 259 (10.3% had moved to other towns, and 50 (2.0% had neither renewed their last municipal census documents nor declared having moved. After using different strategies to track and to retain cohort members, we traced 92% of the CHIS participants. From them, 1,605 subjects answered the follow-up questionnaire. Conclusion The computerized record linkage maximized the success of the follow-up that was carried out 7 years after the baseline interview. The pilot study was useful to increase the efficiency in tracing and interviewing the respondents.

  19. VizieR Online Data Catalog: Li enrichment histories of the thick/thin disc (Fu+, 2018)

    Science.gov (United States)

    Fu, X.; Romano, D.; Bragaglia, A.; Mucciarelli, A.; Lind, K.; Delgado Mena, E.; Sousa, S. G.; Randich, S.; Bressan, A.; Sbordone, L.; Martell, S.; Korn, A. J.; Abia, C.; Smiljanic, R.; Jofre, P.; Pancino, E.; Tautvaisiene, G.; Tang, B.; Lanzafame, A. C.; Magrini, L.; Carraro, G.; Bensby, T.; Damiani, F.; Alfaro, E. J.; Flaccomio, E.; Morbidelli, L.; Zaggia, S.; Lardo, C.; Monaco, L.; Frasca, A.; Donati, P.; Drazdauskas, A.; Chorniy, Y.; Bayo, A.; Kordopatis, G.

    2017-11-01

    To investigate the Galactic lithium enrichment history we se- lect well-measured main sequence field stars with UVES spectra from the GES iDR4 catalogue. In our selection, 1884 UVES stars are marked as field stars, including those of the Galactic disc and halo designated as MW (GEMW) fields, standard CoRoT (GES D_CR) field, standard radial velocity (GES DRV) field, and stars to the Galactic Bulge direction (GEMWBL). (1 data file).

  20. “Your Kung Fu is very good, Master Fiore!” Asian and European fight books in comparison

    Directory of Open Access Journals (Sweden)

    Wetzler Sixt

    2016-12-01

    Full Text Available The phenomenon of the fight book is not restricted to the European tradition. Similar artefacts, usually combining text and image to describe the techniques of close quarter combat with and without weapons, exist also in various Asian cultures, in China, Japan, Korea, and India. In the article, the question shall be raised in how far and to which end fight books of different cultures can be taken into one perspective, and be compared. To do so, similarities and dissimilarities between European and early Chinese fight books will be pointed out, and preliminary areas for comparison will be introduced. The aim of the article is to raise awareness for the topic, and to lay the ground for further discussion between specialists on the respective European and Chinese fields.