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Sample records for ju hsin fu

  1. JU

    African Journals Online (AJOL)

    User

    survey/study tools, data collection, processing and analysis of data, drawing of action plan, ... and writing communication competencies. ... Information technology: this is a skill which grew as the resources in JU improve. This is the area which ...

  2. Using the 3D active fault model to estimate the surface deformation, a study on HsinChu area, Taiwan.

    Science.gov (United States)

    Lin, Y. K.; Ke, M. C.; Ke, S. S.

    2016-12-01

    An active fault is commonly considered to be active if they have moved one or more times in the last 10,000 years and likely to have another earthquake sometime in the future. The relationship between the fault reactivation and the surface deformation after the Chi-Chi earthquake (M=7.2) in 1999 has been concerned up to now. According to the investigations of well-known disastrous earthquakes in recent years, indicated that surface deformation is controlled by the 3D fault geometric shape. Because the surface deformation may cause dangerous damage to critical infrastructures, buildings, roads, power, water and gas lines etc. Therefore it's very important to make pre-disaster risk assessment via the 3D active fault model to decrease serious economic losses, people injuries and deaths caused by large earthquake. The approaches to build up the 3D active fault model can be categorized as (1) field investigation (2) digitized profile data and (3) build the 3D modeling. In this research, we tracked the location of the fault scarp in the field first, then combined the seismic profiles (had been balanced) and historical earthquake data to build the underground fault plane model by using SKUA-GOCAD program. Finally compared the results come from trishear model (written by Richard W. Allmendinger, 2012) and PFC-3D program (Itasca) and got the calculated range of the deformation area. By analysis of the surface deformation area made from Hsin-Chu Fault, we concluded the result the damage zone is approaching 68 286m, the magnitude is 6.43, the offset is 0.6m. base on that to estimate the population casualties, building damage by the M=6.43 earthquake in Hsin-Chu area, Taiwan. In the future, in order to be applied accurately on earthquake disaster prevention, we need to consider further the groundwater effect and the soil structure interaction inducing by faulting.

  3. KuaFu Mission

    Institute of Scientific and Technical Information of China (English)

    XIA Lidong; TU Chuanyi; Schwenn Rainer; Donovan Eric; Marsch Eckart; WANG Jingsong; ZHANG Yongwei; XIAO Zuo

    2006-01-01

    The KuaFu mission-Space Storms, Aurora and Space Weather Explorer-is an "L1+Polar" triple satellite project composed of three spacecraft: KuaFu-A will be located at L1 and have instruments to observe solar EUV and FUV emissions, and white-light Coronal Mass Ejections (CMEs), and to measure radio waves, the local plasma and magnetic field,and high-energy particles. KuaFuB1 and KuaFu- B2 will bein polar orbits chosen to facilitate continuous 24 hours a day observation of the north polar Aurora Oval. The KuaFu mission is designed to observe the complete chain of disturbances from the solar atmosphere to geospace, including solar flares, CMEs, interplanetary clouds, shock waves, and their geo-effects, such as magnetospheric sub-storms and magnetic storms, and auroral activities. The mission may start at the next solar maximum (launch in about 2012), and with an initial mission lifetime of two to three years. KuaFu data will be used for the scientific study of space weather phenomena, and will be used for space weather monitoring and forecast purposes. The overall mission design, instrument complement, and incorporation of recent technologies will target new fundamental science, advance our understanding of the physical processes underlying space weather, and raise the standard of end-to-end monitoring of the Sun-Earth system.

  4. Ju(u)be(l)dused

    Index Scriptorium Estoniae

    2013-01-01

    Viljandis Sakala keskuses toimunud huumoripeol "Grupipilt" selgusid Edmund Valtmani nimelise X Karikatuurivõistluse "Ju(u)be(l)dused" kuus parimat karikaturisti. Ka Edmund Valtmani eluloolisi andmeid

  5. Ju(u)be(l)dused

    Index Scriptorium Estoniae

    2013-01-01

    Viljandis Sakala keskuses toimunud huumoripeol "Grupipilt" selgusid Edmund Valtmani nimelise X Karikatuurivõistluse "Ju(u)be(l)dused" kuus parimat karikaturisti. Ka Edmund Valtmani eluloolisi andmeid

  6. Effects of 5-FU.

    Science.gov (United States)

    Wigmore, Peter M; Mustafa, Sarah; El-Beltagy, Maha; Lyons, Laura; Umka, Jariya; Bennett, Geoff

    2010-01-01

    5-fluorouracil (5-FU) is a chemotherapeutical agent used to treat cancers including breast and colorectal. Working as an antimetabolite to prevent cell proliferation, it primarily inhibits the enzyme thymidylate synthase blocking the thymidine formation required for DNA synthesis. Although having a relatively short half-life (fog" These accounts have come primarily from patients undergoing treatment for breast cancer who report symptoms including confusion and memory impairment, which can last for months to years. Psychometric studies of patients have suffered from confounding variables, which has led to the use of rodent models to assess the cognitive effects of this drug. Researchers have used behavioral and physiological tests including the Morris water maze, novel object location/recognition tests, shock motivated T-maze, sensory gating and conditioning, to investigate the effect of this drug on cognition. The variety of cognitive tests and the difference in dosing and administration of 5-FU has led to varied results, possibly due to the different brain regions associated with each test and the subtlety of the drug's effect, but overall these studies indicates that 5-FU has a negative effect on memory, executive function and sensory gating. 5-FU has also been demonstrated to have biochemical and structural changes on specific regions of the brain. Evidence shows it can induce apoptosis and depress cell proliferation in the neurogenic regions of the adult brain including the sub granular zone (SGZ) within the hippocampus and in oligodendrocyte precursor populations within white matter tracts. Furthermore, investigations indicate levels ofdoublecortin, a marker for newly formed neurons and brain derived neurotrophic factor, a cell survival modulator, are also reduced by 5-FU in the SGZ. Thus, 5-FU appears to have a lasting negative impact on cognition and to affect cellular and biochemical markers in various brain regions. Further work is needed to understand the

  7. FuNNy

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    2005-01-01

    The purpose of this paper is to describe a tool that is easy to use for implementing self learning fuzzy systems. This tool which is called FuNNy generates fuzzy systems. The tool consists of a compiler and a C learning library. The compiler translates a fuzzy system (written in a dedicated...... language, called FuNNy language) to C. The C learning library contains the learning algorithm. The generated C code is simple standard C and therefore it can be applied to all computers with a C-compiler. The learning algorithm is either a gradient descend method based on a numerical calculation...... of the gradient or a random search method. The input fuzzyfication can be described by four different kinds of membership functions. The output fuzzyfication is based on singletons. The rule base can be written in a natural language. The result of the learning is a new version of the fuzzy system described...

  8. Yan Fu's Thoughts of Translation

    Institute of Scientific and Technical Information of China (English)

    韩赵东

    2009-01-01

    Yan Fu was famous translator in Chinese history, and proposed three standards of translation. The theory made great contribution to Chinese translation history. However, with the development of society at present, Yah Fu's theory had been out of date. More and more translators and scholars pay more attention on linguistics to translate appropriately nowadays. It is the aim to analysis this problem in the article and introduces more detailed knowledge to make flourish translation, so that it becomes true that Chinese translation develop step by step.

  9. y Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Socorro Arzaluz Solano

    2006-01-01

    Full Text Available El artículo aborda la aplicación del Programa Hábitat, diseñado por el Gobierno de Vicente Fox en 2002, en dos ciudades fronterizas: Nogales, Sonora, y Ciudad Juárez, Chihuahua. Se analiza la implantación del programa atendiendo sus particularidades, entre otros aspectos, se señalan los diferentes agentes que intervinieron en la ejecución de Hábitat, que pese a la claridad de las reglas, fueron diferentes en cada caso. También, las forma s de participación ciudadana promovidas por los gobiernos locales en ambos casos. Se presentan una reflexión final sobre el desarrollo de Hábitat en la frontera norte, y algunas recomendaciones.

  10. Cummings/Ju - Harvard; Emory | Division of Cancer Prevention

    Science.gov (United States)

    Principal Investigator: Richard D Cummings, PhDInstitution: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Principal Investigator: Tongzhong Ju, MD, PhDInstitution: Emory University, Atlanta, GA |

  11. THE ORIGIN OF ASTEROID 162173 (1999 JU{sub 3})

    Energy Technology Data Exchange (ETDEWEB)

    Campins, Humberto [Physics Department, University of Central Florida, P.O. Box 162385, Orlando, FL 32816-2385 (United States); De Leon, Julia [Department of Edaphology and Geology, University of La Laguna, E-38071 Tenerife (Spain); Morbidelli, Alessandro; Gayon-Markt, Julie; Delbo, Marco; Michel, Patrick [Observatoire de la Cote d' Azur, Universite de Nice Sophia Antipolis (UNS), CNRS UMR7293, F-06108 Nice Cedex 2 (France); Licandro, Javier [Instituto de Astrofisica de Canarias (IAC), C/Via Lactea s/n, E-38205 La Laguna (Spain)

    2013-08-01

    Near-Earth asteroid (162173) 1999 JU{sub 3} (henceforth JU{sub 3}) is a potentially hazardous asteroid and the target of the Japanese Aerospace Exploration Agency's Hayabusa-2 sample return mission. JU{sub 3} is also a backup target for two other sample return missions: NASA's OSIRIS-REx and the European Space Agency's Marco Polo-R. We use dynamical information to identify an inner-belt, low-inclination origin through the {nu}{sub 6} resonance, more specifically, the region with 2.15 AU < a < 2.5 AU and i < 8 Degree-Sign . The geometric albedo of JU{sub 3} is 0.07 {+-} 0.01, and this inner-belt region contains four well-defined low-albedo asteroid families (Clarissa, Erigone, Polana, and Sulamitis), plus a recently identified background population of low-albedo asteroids outside these families. Only two of these five groups, the background and the Polana family, deliver JU{sub 3}-sized asteroids to the {nu}{sub 6} resonance, and the background delivers significantly more JU{sub 3}-sized asteroids. The available spectral evidence is also diagnostic; the visible and near-infrared spectra of JU{sub 3} indicate it is a C-type asteroid, which is compatible with members of the background, but not with the Polana family because it contains primarily B-type asteroids. Hence, this background population of low-albedo asteroids is the most likely source of JU{sub 3}.

  12. Gasoline Consumption Dynamics in Ciudad Juárez, Chihuahua

    OpenAIRE

    Fullerton, Thomas M., Jr.; Munoz Sapien, Gabriel; Barraza de Anda, Martha P.; Dominguez Ruvalcaba, Lisbeily

    2011-01-01

    This research analyzes short-run gasoline consumption dynamics in Ciudad Juárez, Chihuahua, México. Parameter estimation is carried out using linear transfer function ARIMA analysis. This market is of interest because it is influenced by regional, national, and international economic conditions due to its location on the border with the United States. Explanatory variables that satisfy the significance criterion include the real price of gasoline in Ciudad Juárez, the price of gasoline in Ciu...

  13. Experience of ZOU Ju-sheng in Treatment of Dry Eye%邹菊生老师治疗干眼症经验总结

    Institute of Scientific and Technical Information of China (English)

    董志国; 张殷建

    2011-01-01

    ZOU Ju-sheng teacher applied modern anatomy and traditional organs Classification to explore the etiology and pathogenesis of dry eye,and use of ophthalmic XuanFu theory, combined with LunZang relevant theories,using propaganda through the eye of the law of XuanFu to cure disease,available better effect.%邹菊生老师运用现代解剖与传统脏腑分属方式探寻干眼症的病因病机,并运用眼科玄府理论,结合轮脏相关学说,采用宣通眼部玄府之法论治本病,获得了较好疗效.

  14. O direito como juízo

    Directory of Open Access Journals (Sweden)

    Denise Maria Weiss de Paula Machado

    1988-07-01

    Full Text Available This study presents a synthetic and personal view of the consequences arising from the notion of law as justice. For Kelsen, in this "Theory of pure law", human conduct produce facts, justly or injust1y, that become characterized as legal norms. Human behavior is determined by acts of reason, that are defined by a representative (a judge, and then are used as valid norms of justice. The conception of law is, therefore, represented by an ideal object, rational and only apprehensible through abstract processes, following the views of Kelsenians. Without any intent to criticize the "great master of Vienna", a search of the text demonstrates that a neutral ideology, concerning the comprehension and application of law, does not and can not exists law can not depart from empirical reality when following its purpose of promoting the liberty and development of society.O presente texto tem por finalidade apresentar uma visão sintética e pessoal das conseqüências decorrentes da noção do direito como juízo. Para KELSEN, em sua "Teoria pura do direito", a conduta humana produz fatos jurídicos ou injurídicos, conforme assim os caracterizam as normas jurídicas. A conduta humana é determinada por uma razão de agir, que é definida pela representação juízo que o homem tem da norma jurídica 'vigente. A concepção do direito é, pois, representada por um objeto ideal, racional e somente apreensível através de um processo de abstração, segundo a visão Kelseniana. Sem a mínima pretensão de formular críticas ao grande Mestre de Viena, procura o texto demonstrar que a neutralidade ideológica, para a compreensão e aplicação do direito, não existe e nem pode existir, eis que o direito não pode se afastar da realidade empírica, a fim de que possa alcançar sua finalidade de promover a libertação e a evolução da sociedade.

  15. Ciudad Juárez-El Paso

    Directory of Open Access Journals (Sweden)

    César M. Fuentes

    2007-01-01

    Full Text Available El objetivo de este artículo es analizar el impacto espacial de la integración económica entre México y Estados Unidos en el sistema urbano de la región transfronteriza como Ciudad Juárez-El Paso. La integración económica se caracteriza por la presencia de fenómenos de fuerte interacción urbana como la industria maquiladora y el comercio al menudeo entre otros, los cuales muestran un patrón regular de localización en el espacio. El estudio tiene un enfoque espacial por lo que se usó un Sistema de Información Geográfi ca (SIG. La metodología usada para analizar los cambios en el uso del suelo durante el periodo 1984-2004 mediante el análisis de una serie de imágenes del satélite Landsat MSS y Landsat TM. Respecto a la órbita que recorre este satélite, el área de las ciudades estudiadas está registrada en la escena 3238. Los resultados muestran que estamos en la etapa inicial del proceso de conformación de una estructura urbana transfronteriza, en la que cada ciudad tiene una función asignada.

  16. Strategic interactions: Games of the Ju|'hoan.

    Science.gov (United States)

    de Voogt, Alex

    2017-06-27

    Three strategic games played by the Ju|'hoan-a board, a card, and a gesture game-complicate the rhetorics that suggest an evolutionary or psychological significance of play. They are mostly played by adults, although every individual adult does not necessarily engage in each game. The Ju|'hoan card and board game practices were transmitted through contact across large parts of Botswana and Namibia, while the gesture game n!àì has been known in other San communities. It suggests that the significance of strategic games is more likely found in its potential for social interaction (i.e., allowing to overcome cultural divides) than in evolution and psychology. Within the anthropological literature, strategy games were thought to be absent in egalitarian societies, such as that of the Ju|'hoan. Here, the roles of power, competition, and winning were thought to be disruptive and unwanted. A closer examination of the details behind the Ju|'hoan games shows that not only were strategy games adopted and adapted from neighboring societies but that the game of n!àì was developed by the Ju|'hoan into a competitive one. The evolutionary or psychological significance of play is informed by studies on individual play, children's play, and games with informal rules. When considering strategic games throughout history, it is their role of facilitator rather than the playing practice itself that makes games relevant across languages, cultural divides, and sociopolitical boundaries.

  17. Accretion disc flows around FU Orionis stars

    Science.gov (United States)

    Clarke, C. J.; Lin, D. N. C.; Papaloizou, J. C. B.

    1989-01-01

    The accretion disk model of FU Orionis systems in outburst is investigated by examining the time-dependent behavior of a disk around a low-mass protostar that accretes at 0.00001-0.0001 solar masses/yr. It is found that the disk may be stabilized against the thermal ionization instability by the effect of advective heat transport and that it may therefore exist in the quasi-steady-state observed in post-outburst FU Orionis systems. The disk models are used to discuss the cosmochemical consequences of possible FU Ori events during the evolution of the primordial solar nebula.

  18. The new Weibo service for company Ju Zhou Kan

    OpenAIRE

    Wang, Chen

    2012-01-01

    The purpose of this thesis is creating a new Weibo service of Company Ju Zhou Kan. Company Ju Zhou Kan is a real estate magazine company. In order to give a suitable service for the case company, first is to analyze the company competitive and to get the shortages of the company. Second is the theoretical support of social media and Weibo. Third is to find out factors influenced Weibo in the external and internal environment of Kunming. Last is to confirm the new Weibo service and implement W...

  19. 5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

    Directory of Open Access Journals (Sweden)

    Iwao Sasaki

    2010-09-01

    Full Text Available 5-Fluorouracil (5-FU is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

  20. Ju/'h0ansi Adaptations to a Cash Economy

    African Journals Online (AJOL)

    societies, and while cash is certainly sharable, traditional norms for resource .... also taking some new forms in modern life: for example demand sharing of .... Namibians (mostly of Bantu ethnicities) have come to Tsumkwe to take advan- .... non-Ju/'hoansi management and patronage, and demonstrates the tension between ...

  1. Radio continuum from FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, L.F.; Hartmann, L.W.; Chavira, E. (Universidad Nacional Autonoma de Mexico, Coyoacan (Mexico) Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (USA) Instituto Nacional de Astrofisica, Optica y Electronica, Puebla (Mexico))

    1990-12-01

    Using the very large array a sensitive search is conducted for 3.6-cm continuum emission toward four FU Orionis objects: FU Ori, V1515 Cyg, V1057 Cyg, and Elias 1-12. V1057 Cyg and Elias 1-12 at the level of about 0.1 mJy is detected. The association of radio continuum emission with these FU Ori objects strengthens a possible relation between FU Ori stars and objects like L 1551 IRS 5 and Z CMa that are also sources of radio continuum emission and have been proposed as post-FU Ori objects. Whether the radio continuum emission is caused by free-free emission from ionized ejecta or if it is optically thin emission from a dusty disk is discussed. It was determined that, in the archives of the Tonantzintla Observatory, a plate taken in 1957 does not show Elias 1-12. This result significantly narrows the time range for the epoch of the outburst of this source to between 1957 and 1965. 38 refs.

  2. Characterization ofgari andfu-fu preparation procedures in Nigeria.

    Science.gov (United States)

    Westby, A; Twiddy, D R

    1992-03-01

    Processes for the production ofgari, East Nigerianfu-fu and West Nigerianfu-fu are described. Changes in pH value, moisture content, microflora and sugar content of cassava duringgari andfu-fu preparation are reported. Mannitol accumulated during thegari fermentation but not in either of thefu-fu fermentations. During each stage ofgari andfu-fu production, lactic acid bacteria predominated. Homofermentative organisms occurred most frequently in the early stages of each process and heterofermenters in the latter ones. Of the 179 microorganisms that were isolated and characterized fromgari andfu-fu, 52% were able to hydrolyse linamarin and 14% starch.

  3. Sto let dialektologii na stranicah "Južnoslavjanskogo filologa"

    Directory of Open Access Journals (Sweden)

    Remetić Slobodan N.

    2013-01-01

    Full Text Available V rabote govoritsja o nepreryvnosti tradicii dialektologii v žurnale «Južnoslavjanskij filolog» s dnja ego osnovanija do nastojaščego vremeni. Na stranicah avtoritetnogo izdanija predstavleny raboty različnogo profilja: ot fundamenatl'nyh opisanij otdel'nyh tipov govorov do informacii o napečatannyh v strane i za rubežom dialektologičeskih monografij i diskussij. Sredi issledovanij, opublikovannyh na stranicah «Južnoslavjanskogo filologa», preobladajut raboty, posvjaščennye problematike štokavskogo dialektnogo kompleksa, odnako pri ltom pečatalis' i mnogie raboty, posvjaščennye obsuždeniju voprosov čakavskogo i kajkavskogo narečij. V «Južnoslavjanskom filologe» svoi trudy opublikovali naši vidnye dialektologi: A. Belič, M. Rešetar, J. Vuković, P. Ivič, M. Pešikan, D. Petrovič i dr. [Projekat Ministarstva nauke Republike Srbije, br. 178020: Dijalektološka istraživanja srpskog jezičkog prostora

  4. Synthesis and characterization of HPMA copolymer-5-FU conjugates

    Institute of Scientific and Technical Information of China (English)

    Fang Yuan; Fu Chen; Qing Yu Xiang; Xuan Qin; Zhi Rong Zhang; Yuan Huang

    2008-01-01

    N-(2-Hydroxypropyl)methacrylamide copolymer-5-fluorouracil (PHPMA-FU)conjugates were synthesized by a novel and simplified synthetic mute,and characterized by UV,FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU)was 3.41 ± 0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.

  5. DS/EN 1520 FU:2015

    DEFF Research Database (Denmark)

    Goltermann, Per; Cornelius, Thomas

    DS/EN 1520 FU er en sammenskrivning af de væsentligste afsnit af standarden med tilhørende dansk anneks, hvor de danske værdier er angivet. Sammenskrivningen gør det lettere for den projekterende at beregne de fleste konstruktioner efter DS/EN 1520-systemet. En konstruktion, der opfylder kravene i...... DS/EN 1520 FU, vil også tilfredsstille de tilsvarende krav i DS/EN 1520. DS/INF 168, Supplerende vejledning ved brug af EN 1520, Præfabrikerede armerede elementer af letbeton med lette tilslag og åben struktur er også en del af sammenskrivningen. Denne udgave er også opdateret med seneste nationale...

  6. KuaFu Mission: The scientific payload of KuaFu-B

    Science.gov (United States)

    Wang, J.-S.; Tu, C.-Y.; Schwenn, R.; Donovan, E.; Xia, L.-D.; Zhang, Y.-W.; Kuafu Team

    The KuaFu mission would consist an L1 satellite KuaFu-A and a polar satellite pair KuaFu B1 B2 The mission is designed to explore the whole cause-and-result chain in solar-terrestrial space The two KuaFu-Bs will have the same payload sets and fly on the same polar orbit plane but with a phase difference of half period The preferred perigee is 1 8 Re and the apogee is 7 Re This orbit design will support a 24 times 7 full-covered observation on the northern auroral oval by the onboard aurora cameras The suggested payloads consist of a Far Ultraviolet Auroral Monitoring Camera UVAMC a FUV Imaging Spectrometer FUVSI a Wide Field Auroral Imager WFAI a Fluxgate Magnetometer FGM a High Energy Charged Particle Experiment HECPE an Imaging energetic electron and proton instrument IEPS a Neutral Atom Imager on KuaFu NAIK a Fast Plasma Pitch Angle Instrument FPI an Ion Mass Spectrometer IMS FPI and IMS were suggested to merge and a Tri-Band Beacon TBB

  7. Note sur l’adverbe temporel już et ses correspondants français

    Directory of Open Access Journals (Sweden)

    Małgorzata Nowakowska

    2015-11-01

    Full Text Available A remark concerning the temporal adverb już and its French equivalents Generally speaking, this contrastive study of the Polish temporal adverb już and the French déjà is based around the idea that już and déjà have an invariant meaning but it is also true that they follow different idiosyncratic usages. This article has two parts. First, the authors show the usages of już which are equivalent to those of déjà. These usages appear when już and déjà are put in a specific verbal context. The authors describe the four cases in which już and déjà are equivalent: “precocity of event”, existential usage, iterative-continuative usage, experiential perfect usage. Secondly, the authors analyze four cases in which the Polish adverb już can’t be translated by the French déjà. These incompatibilities can be explained by either morphological idiosyncrasy or the conventionalization of deictic meaning of już, which is absent of déjà.

  8. Spitzer Observations of Spacecraft Target 162173 (1999 JU3)

    CERN Document Server

    Campins, H; Kelley, M; Fernandez, Y; Licandro, J; Delbo, M; Barucci, A; Dotto, E; 10.1051/0004-6361/200912374

    2009-01-01

    Near-Earth asteroid 162173 (1999 JU3) is the primary target of the Hayabusa-2 sample return mission, and a potential target of the Marco Polo sample return mission. Earth-based studies of this object are fundamental to these missions. We present a mid-infrared spectrum (5-38 microns) of 1999 JU3 obtained with NASA's Spitzer Space Telescope in May 2008. These observations place new constraints on the surface properties of this asteroid. To fit our spectrum we used the near-Earth asteroid thermal model (NEATM) and the more complex thermophysical model (TPM). However, the position of the spin-pole, which is uncertain, is a crucial input parameter for constraining the thermal inertia with the TPM; hence, we consider two pole orientations. In the extreme case of an equatorial retrograde geometry we derive a lower limit to the thermal inertia of 150 J/m^2/K/s^0.5. If we adopt the pole orientation of Abe et al. (2008a) our best-fit thermal model yields a value for the thermal inertia of 700+/-200 J/m^2/K/s^0.5 and e...

  9. The FU gene and its possible protein isoforms

    Directory of Open Access Journals (Sweden)

    Nöthen Markus M

    2004-07-01

    Full Text Available Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci. Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors. Since Ci and GLI are targets of Hedgehog signaling in development and morphogenesis, it is expected that FU plays an important role in Sonic, Desert and/or Indian Hedgehog induced cellular signaling. Results The FU gene was identified on chromosome 2q35 at 217.56 Mb and its exon-intron organization determined. The human developmental disorder Syndactyly type 1 (SD1 maps to this region on chromosome 2 and the FU coding region was sequenced using genomic DNA from an affected individual in a linked family. While no FU mutations were found, three single nucleotide polymorphisms were identified. The expression pattern of FU was thoroughly investigated and all examined tissues express FU. It is also clear that different tissues express transcripts of different sizes and some tissues express more than one transcript. By means of nested PCR of specific regions in RT/PCR generated cDNA, it was possible to verify two alternative splicing events. This also suggests the existence of at least two additional protein isoforms besides the FU protein that has previously been described. This long FU and a much shorter isoform were compared for the ability to regulate GLI1 and GLI2. None of the FU isoforms showed any effects on GLI1 induced transcription but the long form can enhance GLI2 activity. Apparently FU did not have any effect on SUFU induced inhibition of GLI. Conclusions The FU gene and its genomic structure was identified. FU is a candidate gene for SD1, but we have not identified a pathogenic mutation in the FU coding region in a family with SD1. The sequence information and expression analyses show that transcripts of different sizes are expressed and subjected to alternative splicing

  10. White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study.

    Science.gov (United States)

    Chibber, Sandesh; Farhan, Mohd; Hassan, Iftekhar; Naseem, Imrana

    2011-10-01

    5-Fluorouracil (5-FU) is a potent photosensitizer used in colon and rectal cancers. 5-FU on galvanostatic electrolysis or radiation-induced oxidation of aqueous solution yields N(1)-C(5)-linked dimmer hydrate of 5-FU. Copper is presently associated with chromatin; in cancer cells the concentration of copper is very high. It has been shown to be capable of mediating the action of several anticancer drugs through the production of reactive oxygen species (ROS). The objective of the present study is to determine the Cu (II)-mediated anticancer mechanism of 5-FU under photo-illumination as well as 5-FU alone. We have shown that a pro-oxidant action was enhanced when Cu (II) was used with 5-FU as compared to 5-FU alone. This may be due to the inhibition of dimerization of 5-FU when present in combination with Cu (II) under photo-illumination. It was also shown that 5-FU alone as well as in combination with Cu (II) was able to generate oxidative stress in lymphocyte which is inhibited by scavengers of ROS. Moreover, the results of Fourier-transformed infrared spectra lead to the conclusion that the dimerization of 5-FU was inhibited when used in combination with Cu (II). It was due to the interaction of 5-FU with Cu (II). Hence, we propose that during chemoradiotherapy with 5-FU, the endogenous copper is mobilized by 5-FU, leading to the generation of ROS which cause oxidative stress and possibly cancer cell death by apoptosis.

  11. The Hot Inner Disk of FU Ori

    CERN Document Server

    Zhu, Zhaohuan; Calvet, Nuria; Hernandez, Jesus; Muzerolle, James; Tannirkulam, Ajay-Kumar

    2007-01-01

    We have constructed a detailed radiative transfer disk model which reproduces the main features of the spectrum of the outbursting young stellar object FU Orionis from ~ 4000 angstrom, to ~ 8 micron. Using an estimated visual extinction Av~1.5, a steady disk model with a central star mass ~0.3 Msun and a mass accretion rate ~ 2e-4 Msun/yr, we can reproduce the spectral energy distribution of FU Ori quite well. With the mid-infrared spectrum obtained by the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope, we estimate that the outer radius of the hot, rapidly accreting inner disk is ~ 1 AU using disk models truncated at this outer radius. Inclusion of radiation from a cooler irradiated outer disk might reduce the outer limit of the hot inner disk to ~ 0.5 AU. In either case, the radius is inconsistent with a pure thermal instability model for the outburst. Our radiative transfer model implies that the central disk temperature Tc > 1000 K out to ~ 0.5 - 1 AU, suggesting that the magnetorotationa...

  12. Juárez: la ciudad de las últimas cosas

    Directory of Open Access Journals (Sweden)

    David Barrios Rodríguez

    2016-05-01

    Full Text Available El presente artículo plantea el caso de Ciudad Juárez, México como el de un laboratorio social en materia de relaciones laborales, distintos tipos de violencia, exterminio de grupos específicos y la militarización de la vida cotidiana. Asimismo se establecen las condiciones de desarrollo excluyente del proyecto de ciudad. Además de ello abordamos el proceso que hizo que durante el periodo 2008-2011 fuese considerada la ciudad más violenta del mundo por sus tasas de asesinato. Finalmente se establece la importancia de la población y sus activistas para posicionar un discurso contra la militarización de su ciudad y el país.

  13. Daudzlietotāju režīms OWL redaktorā

    OpenAIRE

    Putniņš, Jānis

    2010-01-01

    Darbs „Daudzlietotāju atbalsts OWL redaktorā” apraksta kā var strādāt ar OWL redaktoru TDA platformā daudzlietotāju režīmā. Tas nozīmē iespēju vairākiem lietotājiem vienlaikus apstrādāt kādu UML/OWL diagrammu ar SVN repozitorija starpniecību. Modulis realizēts Lua valodā.

  14. Some Thoughts on the English Version of "Fu Wa"

    Institute of Scientific and Technical Information of China (English)

    易高燕

    2009-01-01

    There have been many disputes about the translation of the Beijing 2008 Olympiad Mascots since it was first announced in 2005.And it was at last translated directly as the Chinese phonetic alphabet " Fu Wa".So this essay is going to explore some ideas of the English translation of "Fu Wa",and meanwhile discuss some translation approaches of culture-loaded words.

  15. Rüütel kutsus Juštšenko Eestisse

    Index Scriptorium Estoniae

    2005-01-01

    President Arnold Rüütel saatis Viktor Juštšenkole õnnitluse presidendivalimistel saavutatud edu puhul, kutsudes teda Eestisse visiidile. Ilmunud ka Vaba Eesti Sõna = Free Estonian Word (2005) 18. jaan., lk. 2

  16. Analysis of the Lexical Meaning of “Ao An Quan Shi”in Wen-hsin Tiao-Lung%《文心雕龙》“傲岸泉石”词义考辨

    Institute of Scientific and Technical Information of China (English)

    吕晓洁

    2014-01-01

    “Ao An Quan Shi”comes from the Poetic Praise in the Prelude of Wen-hsin Tiao-Lung .Its meaning relates to a series of relationships of the literary creation,such as the subject and object,and the people and object.It is even the concentration of the literary thoughts of the whole book.Previous explanations for it can be roughly divided into four categories:indulging in landscape,arrogant seclusion,nature and naturalness,and peripateticism and freedom.Each of them has merits and demerits.Combined with the specific context,“Ao An Quan Shi”focuses on the role of aesthetic subject.It refers to the free state in literary creation.“Ao An Quan Shi”and“Nature’s Assistance to Literary Creation”emphasizing the role of the aesthetic object constitute the basis of Liu Xie’s literature theories.%“傲岸泉石”出自《文心雕龙·序志》篇“赞曰”,其词义涉及文学创作的主体与客体、人与物等一系列关系,可以说是全书文论思想的一个浓缩。以往学界对它的解释大致可以归为四种:纵情山水说、高傲隐居说、自然本然说、逍遥自得说,每种说法都有合理之处,亦有不足。结合具体语境考察,可知“傲岸泉石”强调的是审美主体的作用,指的是文学创作时一种逍遥自得的本然状态。它与强调审美客体作用的“江山之助”一起构成了刘勰文学理论的根基。

  17. Dinámica del Consumo de Gasolina en Ciudad Juárez, Chihuahua

    OpenAIRE

    Fullerton, Thomas M., Jr.; Munoz Sapien, Gabriel; Barraza de Anda, Martha P.; Dominguez Ruvalcaba, Lisbeily

    2011-01-01

    This research analyzes short-run gasoline consumption dynamics in Ciudad Juárez, Chihuahua, México. Parameter estimation is carried out using linear transfer function ARIMA analysis. This market is of interest because it is influenced by regional, national, and international economic conditions due to its location on the border with the United States. Explanatory variables that satisfy the significance criterion include the real price of gasoline in Ciudad Juárez, the price of gasoline in ...

  18. Antiques in the Alley: Guan Fu Classical Art Museum

    Institute of Scientific and Technical Information of China (English)

    ZhangJing

    2003-01-01

    Nestled in an alley off South Chaoyangmen Nei Street in Beijing is Guan Fu Classical Art Museum, China's first privately owned and operated antique museum run by one of the country's most ardent collectors,

  19. Antiques in the Alley:Guan fu Classical Art Museum

    Institute of Scientific and Technical Information of China (English)

    Zhangjing

    2003-01-01

    Nestled in an alley off South chaoyang men nei street in beijing is guan fu classical art museum,china's first privately owned and operated antique museum run by one of the country's most ardent collectors.

  20. Health benefits of Kung Fu: a systematic review.

    Science.gov (United States)

    Tsang, Tracey Wai Man; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2008-10-01

    The Chinese martial arts (Kung Fu) have existed for centuries and are generally accepted as being beneficial for health without much empirical data. The aim of this systematic review was to assess the health effects of "hard" Kung Fu styles by performing electronic and manual searches of the literature. The aspects of health and the Kung Fu style examined varied between most studies; in some cases, the martial art group consisted of practitioners of other martial art styles also. Of 2103 references identified, only nine papers were eligible and reviewed. All were observational studies, observing a range of health aspects possibly related to Kung Fu training or performance. Our findings suggest that there is no evidence that Kung Fu practice is associated with the prevention or treatment of any health condition. However, as a moderate- to high-intensity form of aerobic exercise, it may confer benefits similar to those attributed to other aerobic training modalities. However, this hypothesis remains to be tested in clinical trials. Physiological benefits (e.g., aerobic capacity and bone density) may be associated with long-term Kung Fu practice. Future research in this area should adopt experimental designs, clearly identifying eligibility criteria, testing and training protocols, and include health-related outcomes and documentation of adverse events, to advance knowledge in this field.

  1. 5-FU-induced peripheral neuropathy: a rare complication of a well-known drug.

    NARCIS (Netherlands)

    Laarhoven, H.W.M. van; Verstappen, C.C.P.; Beex, L.V.A.M.; Kappelle, A.C.; Punt, C.J.A.

    2003-01-01

    Peripheral neuropathy is a rare complication of the commonly used cytotoxic drug 5-fluorouracil (5-FU). We report a case of 5-FU-induced peripheral neuropathy in a patient with metastatic colorectal carcinoma. Discontinuation of 5-FU therapy is recommended in case of 5-FU-related neurotoxicity.

  2. Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

    Directory of Open Access Journals (Sweden)

    Kravik Katherine L

    2006-05-01

    Full Text Available Abstract Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate and strong resistance to 5-FU, respectively, markedly-reduced levels of 5-FU-induced apoptosis, and alterations in expression levels of a number of key cell cycle- and apoptosis-regulatory genes as a result of resistance development. The aim of the present study was to determine potential differential responses to 8 and 24-hour 5-FU treatment in these resistant cell lines. We assessed levels of 5-FU uptake into DNA, cell cycle effects and apoptosis induction throughout treatment and recovery periods for each cell line, and alterations in expression levels of DNA damage response-, cell cycle- and apoptosis-regulatory genes in response to short-term drug exposure. Results 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA, cell cycle-regulatory (CDKN1A, and apoptosis-regulatory pathways (FAS, and apoptosis induction in the parental and resistant cell lines. Levels of 5-FU incorporation into DNA were similar for the cell lines. The pattern of cell cycle progression during recovery demonstrated consistently that the 5-FU-resistant cell lines had the smallest S phase fractions and the largest G2(/M fractions. The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days compared to the other two cell lines. The moderately 5-FU-resistant ContinB cell line had comparatively lower apoptotic levels than the parental cells during treatment and recovery

  3. Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits.

    Science.gov (United States)

    Avsaroglu, H; Bull, S; Maas-Bakker, R F; Scherpenisse, P; Van Lith, H A; Bergwerff, A A; Hellebrekers, L J; Van Zutphen, L F M; Fink-Gremmels, J

    2008-08-01

    Medetomidine is an alpha(2)-adrenoceptor agonist with sedative and analgesic properties. Previously we demonstrated significant differences in the response to medetomidine between two inbred rabbit strains, denoted IIIVO/JU and AX/JU. The aim of the present study was twofold: first, to compare the hepatic CYP450 enzyme activities between these rabbit strains [n = 13(male male,7 female female)/strain]. To this end, liver microsomes were incubated with known fluorescent substrates for the major drug-metabolizing CYP450 isoforms. A comparison of the obtained results indicated significant gender differences as well as differences between the two rabbit inbred strains. Secondly, the biotransformation rate of medetomidine in liver microsomes of both rabbit strains was determined using liquid chromatography coupled to tandem mass spectrometry. The rate of hydroxymedetomidine and medetomidine carboxylic acid formation was found to be significantly higher in the AX/JU strain. Specific CYP2D and CYP2E inhibitors could decrease the formation of both metabolites. Significant correlations were found between the rate of biotransformation of medetomidine and the activities of CYP2D and CYP2E, as well as between CYP450 enzyme activities and the anaesthetic response to medetomidine.

  4. Sindicatos en Ciudad Juárez: Historia y debilidad sindical

    Directory of Open Access Journals (Sweden)

    Cirila Quintero Ramírez

    1996-01-01

    Full Text Available This work analyzes the evolution of the labor unions in Ciudad Juárez for three decades of the maquiladora industry. Postulates as a main idea, the existence of a weakening of the labor unions in the rnaquiladoras as a consequence of two central factors: the absence of a labor union trajectory in the region, and the persistence of economical activities in Ciudad Juárez that depend on the American economy, and the existence of a factionalism inter and intralabor union in the main workers associations in the city, that has permitted the defeal of not onIy the official movements, but the independent ones too. The weakening ol the labor union. has also conducted to a policy ol apathy, conformity, and ol high colaboration with the investors, that has tumed the labor unions in Ciudad Juárez into an expression of subordinated labor unions, that legitimates their perrnanency in the rnaquiladoras are mostly to their link with investors than with their members. This article allows us to see two future sceneries in the city ol Ciudad Juárez: the accentuation of this kind of behavior in labor unions, or the disappearance ol labor unions in the maquiladoras.

  5. MFL-P Chemotherapy for Pretreated Metastatic Breast Cancer Patients: A Regimen with Triple Biochemical Modulation by MTX-5FU, LV-5FU and 5FU-CDDP.

    Science.gov (United States)

    Kan; Honda

    1999-07-25

    BACKGROUND: Chemotherapeutic regimens, such as cyclophosphamide + doxorubicin + 5FU (CAF) or cyclophosphamide + methotrexate + 5FU (CMF), are sometimes used in combination with endocrine or radiotherapy as a standard first line of treatment for recurrent or metastatic breast cancer. However, many cases are, or become, refractory to these treatments. METHODS: Twenty-one women with recurrent or metastatic breast cancer who previously underwent treatment were administered our original regimen of combinationchemotherapy, MFL-P: Day 1, bolus methotrexate (MTX) 50 mg/body (median dose, 33 mg/m(2); range, 29-35 mg/m(2)) and 4 hours later 5-fluorouracil (5FU) 750 mg/body/h (median dose, 497 mg/m(2)/h; range, 441-528 mg/m(2) /h); Days 2-3, bolus leucovorin(LV) 15 mg/body every 8 h x 3; Days 2-5, 72 hours continuous 5FU 750 mg/body/24h; Day 6, cisplatin (CDDP) 50 mg/body/h (median dose, 33 mg/m(2)/h; range, 29-35 mg/m(2) /h) with sufficient hydration. The subjects ranged in age from 26 to 63 years (mean age, 51.3 years). RESULTS: One complete and 9 partial responses were achieved among the 20 patients (response rate, 50%). In 1 patient, diffuse liver metastasis was not measurable. Among various metastatic sites, a higher response rate was observed especially for soft tissue lesions (skin, chest wall and lymph nodes; 9 responders among 11 lesions). On the other hand, in visceral or skeletal metastases, the response rate was poor. The adverse effects were tolerable in all patients, except for common low-grade stomatitis or anorexia. CONCLUSION: MFL-P is useful as a second or third line of therapy for patients with refractory, recurrent or metastatic breast cancer with soft tissues lesions.

  6. Eric Cantona: Fußball-Ikone der modernen Medienwelt

    Directory of Open Access Journals (Sweden)

    Martin Wassermair

    2010-03-01

    Full Text Available In Unterhaltungsindustrie und Massenmedien nimmt der Sport eine im wahrsten Sinne des Wortes bewegende Rolle ein. Er ist zugleich Wettkampf-Arena und Wunschmaschine, Werbefläche und Starproduktion. Dass die Erscheinungsformen des Sports in der modernen Medienwelt einer rasanten Dynamik und Wechselbeziehung unterliegen, ist am Beispiel des Massenphänomens Fußballs vielleicht am deutlichsten abzulesen.

  7. 论扬雄赋%On YANG XIONG-FU

    Institute of Scientific and Technical Information of China (English)

    蓝旭

    2001-01-01

    As a renowned writer of Fu (赋), Yangxiong attached importance to satire, develop-ing new satirical techniques. He mingled light satire with the main body of Dafu (大赋)totouch on the work's themea. He utilized many literary quotations within his Dafu and em-ployed narration interspersed with commentary to give voice to many of his personal medita-tions on history and antiquity. The achievement of his Dafu is that he changed the traditionalstyle in which description and satire come together. He attained a transition from Dafu toYanzhi -Fu (言志赋), which gave expression to his aspirations in his later life. His Dafu alsoinspired the Jixing-fu (纪行赋) writers. Yangxiong'Yanzhi-fu embodies a mixture of Con-fucianism, Daoism, and Sso (aliterary style of the Pre-qin times). His works demonstratea pursuit for individual independence, freedom, and the preservation of moral value. Bridgingthe transition from Dafu to Yanzhi-fu, his works contain great significance to HanFu'history: he isthe linkbetween early and late Han Fu.%扬雄大赋重视讽谏,并开辟了新的讽谏手法,即正文中杂以微讽,以点醒题旨;大量用典,夹叙夹议,以及结合行踪咏史怀古的体格。其意义在于试图摆脱描写与讽谏游离的格套,从而自然过渡到他本人后期的言志赋,也启发了以后的纪行赋作家。扬雄的言志赋则体现出儒、道、骚融合的倾向,既追求个体的独立和自由,又并不废弃道德操守的价值。他的创作从大赋到言志赋的发展,在汉赋史上具有承上启下的意义。

  8. Translation Style of Fu Lei's—The Conquest of Happiness

    Institute of Scientific and Technical Information of China (English)

    李敏

    2016-01-01

    Mr. Fu Lei was a famous French literature translator. Most of the works are translated from Balzac, Roman Rolland, Voltaire, Merimee ect. This article through the analysis of The Conquest of Happiness to further study on Fu lei's translation style.

  9. Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.

    Science.gov (United States)

    Kline, Christina Leah; Sheikh, Hassan S; Scicchitano, Angelique; Gingrich, Rebecca; Beachler, Cheryl; Finnberg, Niklas K; Liao, Jason; Sivik, Jeffrey; El-Deiry, Wafik S

    2011-10-01

    Efforts to improve efficacy and minimize toxicity have led to pharmacokinetic monitoring of plasma 5-Fluorouracil (5-FU) levels in colorectal cancer patients undergoing chemotherapy. We observed variation in basal 5-FU levels in 21 patients and significant variation during subsequent dose optimization. Tumor KRAS, BRAF mutations and TS mRNA levels were determined. Regimens included FOLFOX6 + Avastin (N = 8), FOLFOX6 (N = 11), FOLFIRI (N = 1) and FOLFOX4 (N = 1). Mutations identified in tumors included G12V KRAS (N = 2), G12A KRAS (N = 1), and V600E BRAF (N = 3). Six-of-eleven patients with normalized tumor TS mRNA levels 5-FU AUC of 20 mg.h/L or greater, and 80% of patients (4 of 5) with TS levels > 4.0 had a plasma 5-FU AUC of less than or equal to 20 mg.h/L. Approximately 2/3 of patients achieved therapeutic 5-FU AUC levels with 0-2 dose adjustments while a sub-group of ~1/3 of patients slowly achieved therapeutic levels (> 3-4 dose increases leading to supra-therapeutic 5-FU and subsequent reductions to lesser than original doses). Liver metastases and tumor TS levels did not fully account for variable 5-FU AUC optimization patterns. The 5-FU level during continuous infusion was half-therapeutic in one patient who received FOLFOX4. The observed heterogeneous patterns at baseline and during dose optimization of 5-FU levels suggest variations in 5-FU metabolism among treated patients. Physiological and/or genetic differences underlying heterogeneity in 5-FU levels during dose optimization require further study of patient demographics, single nucleotide polymorphisms in Dihydropyrimidine Dehydrogenase (DPD), TS, or other genes that impact 5-FU metabolism and gene expression changes in liver after 5-FU therapy.

  10. Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer.

    Science.gov (United States)

    Maisey, Nick; Chau, Ian; Cunningham, David; Norman, Andrew; Seymour, Matt; Hickish, Tamas; Iveson, Tim; O'Brien, Mary; Tebbutt, Niall; Harrington, Angela; Hill, Mark

    2002-07-15

    To compare protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin (MMC) in patients with advanced pancreatic cancer in a multicenter, prospectively randomized study. Two hundred eight patients were randomized to PVI 5-FU (300 mg/m(2)/d for a maximum of 24 weeks) or PVI 5-FU plus MMC (7 mg/m(2) every 6 weeks for four courses). The major end points were tumor response, survival, toxicity, and quality of life (QOL). The two treatment groups were balanced for baseline demographic factors, and 62% had metastatic disease. The overall response rate was 8.4% (95% confidence interval [CI]) 3.2% to 13.7% for patients treated with PVI 5-FU alone compared with 17.6%; 95% CI 10.3% to 25.1% for PVI 5-FU plus MMC (P =.04). Median failure-free survival was 2.8 months for PVI 5-FU and 3.8 months for PVI 5-FU plus MMC (P =.14). Median survival was 5.1 months for PVI 5-FU and 6.5 months for PVI 5-FU plus MMC (P =.34). Toxicities in both arms were mild. There was an increased incidence of neutropenia in the 5-FU plus MMC arm (P PVI 5-FU plus MMC resulted in a superior response rate in comparison with PVI 5-FU alone in advanced pancreatic cancer, but this did not translate into a survival advantage. These results emphasize the importance of chemotherapy in this setting and the continuing value of the fluoropyrimidines in pancreatic cancer.

  11. Benito Juárez: ¿más que un Aprendiz de Masón?

    OpenAIRE

    Martínez Moreno, Carlos F.

    2016-01-01

    El estudio historiográfico muestra que es una idea ampliamente aceptada que Benito Juárez fue iniciado en la masonería en el Rito Nacional Mexicano; sin embargo, hay quien afirma que es improbable que Juárez haya recibido más allá del grado de Aprendiz de Masón, a causa de los movimientos bélicos que provocaron sus constantes viajes por la República Mexicana y el extranjero. El objetivo central del presente artículo es analizar algunas hipótesis para buscar dilucidar si Juárez pudo haber reci...

  12. Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.

    Science.gov (United States)

    Codacci-Pisanelli, G; Noordhuis, P; van der Wilt, C L; Peters, G J

    2008-06-01

    Fluorouracil (5FU) acts by RNA-incorporation and inhibition of thymidylate synthase; the first action is counteracted by uridine, and the second is enhanced by leucovorin (LV). Growth inhibition of C26-10 colon cancer cells by 5FU was enhanced by LV and rescued by uridine, but 5FU-LV was only partially rescued by uridine. In WiDr cells, 5FU sensitivity was not enhanced by LV, while both 5FU and 5FU-LV were rescued by uridine. Intermediate trends were found in SW948 and HT29 cells. Uridine rescue in mice allowed 1.5-fold increase in 5FU dose, leading to 2-fold increase in the antitumor effect and thymidylate synthase inhibition in resistant Colon-26 tumors. In the sensitive Colon-26-10 tumor, uridine rescue decreased 5FU-RNA incorporation > 10-fold, without affecting the antitumor activity. The use of LV and uridine can differentiate between two mechanisms of action of 5FU.

  13. Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate

    Institute of Scientific and Technical Information of China (English)

    Jie Li; Li Hai; Wei Jia Liu; Xiao Chun Wu; Yong Wu

    2009-01-01

    A series of hepatic targeting drugs,5-Fu-cholic acid conjugate T1-T5,were synthesized.5-Fu and cholic acid was selected as starting material,after N-hydroxymethylation,condensation,hydrogenolysis to obtain carboxylated 5-Fu 5a--e.Carboxylated 5-Fu 5a--e were eondensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a-e,7a-e were deproteeted to get T1-T5.

  14. Hodorkovski - Venemaa kuulsaim vang / Cyril Tuschi, Vladimir Juškin, Mart Helme ; vestlust juhtis Tunne Kelam

    Index Scriptorium Estoniae

    Tuschi, Cyril, 1969-

    2011-01-01

    Dokumentaalfilmi "Hodorkovsky" režissöör Cyril Tuschi, Balti Vene Uuringute Keskuse direktor Vladimir Juškin ja suursaadik Mart Helme filmi peategelasest Mihhail Hodorkovskist ja Venemaa sisepoliitlisest olukorrast

  15. Loodav Vene natsiseadus ähvardab naabreid / Argo Ideon ; komment. Vladimir Juškin ja Marko Mihkelson

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2009-01-01

    Seaduseelnõust, millega tahetakse luua õiguslik raamistik võitluseks endisel Nõukogude Liidu alal väidetavalt vohava natsliku ideoloogia ja selle toetajatega. Kommenteerivad Vladimir Juškin ja Marko Mihkelson

  16. E-komercija un paterētāju aizsardzība

    OpenAIRE

    Mošenoka, Olga

    2013-01-01

    Bakalaura darba temats – E-komercija un patērētāju aizsardzība. Izstrādātais darbs sastāv no 70 lapaspusēm, 19 attēliem . Bakalaura darba mērķis: Izpētīt kas ir elektroniska komercija, kādas ir e-komercijas priekšrocības un trūkumi, kas ir e-komercijas dalībnieki, patērētāju aizsardzība. Izvirzītie darba uzdevumi: •noskaidrot kas ir e-bizness un e-komercija; •noskaidrot e-komercijas dalībniekus, priekšrocības, trūkumus; •iepazīties ar visveiksmīgākajiem e-komercijas piem...

  17. Rotational Characterization of Hayabusa II Target Asteroid (162173) 1999 JU3

    CERN Document Server

    Moskovitz, Nicholas; Pan, Kang-Shian; Osip, David; Pefkou, Dimitra; Melita, Mario; Elias, Mauro; Kitazato, Kohei; Bus, Schelte; DeMeo, Francesca; Binzel, Richard; Abell, Paul

    2013-01-01

    The Japanese Space Agency's Hayabusa II mission is scheduled to rendezvous with and return a sample from the near-Earth asteroid (162173) 1999 JU3. Previous visible-wavelength spectra of this object show significant variability across multiple epochs which could be the result of a compositionally heterogeneous surface. We present new visible and near-infrared spectra to demonstrate that thermally altered carbonaceous chondrites are plausible compositional analogs, however this is a tentative association due to a lack of any prominent absorption features in our data. We have also conducted a series of high signal-to-noise visible-wavelength observations to investigate the reported surface heterogeneity. Our time series of visible spectra do not show evidence for variability at a precision level of a few percent. This result suggests two most likely possibilities. One, that the surface of 1999 JU3 is homogenous and that unaccounted for systematic effects are causing spectral variation across epochs. Or two, tha...

  18. La Nephila Maculata. Jünger y la experiencia de la catástrofe

    Directory of Open Access Journals (Sweden)

    Carrasco-Conde, Ana

    2015-12-01

    Full Text Available The present work intends to approach the testifying form of Ernst Jünger to realize the history with the intention, firstly, of investigating in the sense that has for the German author the experience of the catastrophe, the war and the pain and, secondly, of explaining the constitutive elements of his particular concept of history.El presente trabajo trata de abordar la forma testimonial de Ernst Jünger de dar cuenta de la historia con el propósito, en primer lugar, de indagar en el sentido que tiene para el autor alemán la experiencia de la catástrofe, la guerra y el dolor y, en segundo lugar, de explicar los elementos constitutivos de su particular concepto de historia.

  19. [Modeling 5-FU clearance during a chronomodulated infusion].

    Science.gov (United States)

    Kwiatkowski, F; Chevalier, V; Chevrier, R; Richard, D; Cure, H; Chollet, P

    2003-06-01

    Drugs pharmacokinetic control is a usual practice in case of flat continuous infusions. It enables among others, to modulate delivered doses when drug concentrations in blood appear too high. With chronotherapy, this possibility becomes more difficult because of sinusoidal outflows of infusion. We propose here a method that enables this follow-up, established through the study of 21 metastatic colorectal cancer patients, treated with a chronomodulated infusion of high dose 5-fluoro-uracil (5-FU) and folinic acid. This pharmacokinetic follow-up permitted the modelisation of 5-FU clearance and the calculation of an index, which was, in our study, correlated to the treatment response and also to main encountered toxicities.

  20. Visuospatial attention and motor skills in kung fu athletes.

    Science.gov (United States)

    Muiños, Mónica; Ballesteros, Soledad

    2013-01-01

    The present study compared the performance of a group of sixteen kung fu athletes with that of a control group of fourteen nonathletes on a speeded visuospatial task and a hand-tapping motor task. In the visuospatial task the results showed that athletes were faster than the control participants when stimuli were presented at the periphery of the visual field at a middle and high presentation speed with short interstimulus intervals. Athletes were also significantly faster than nonathlete participants when performing motor actions such as hand-tapping with their dominant hand but groups did not differ with the nondominant hand. These results support the view that athletes perform some speeded visuospatial and motor tasks faster than nonathletes under certain conditions. The findings suggest that, after several years of practice, kung fu athletes develop certain skills that allow them to perform motor speed maneuvers under time pressure conditions.

  1. SPHERES, Jülich's high-flux neutron backscattering spectrometer at FRM II.

    Science.gov (United States)

    Wuttke, Joachim; Budwig, Alfred; Drochner, Matthias; Kämmerling, Hans; Kayser, Franz-Joseph; Kleines, Harald; Ossovyi, Vladimir; Pardo, Luis Carlos; Prager, Michael; Richter, Dieter; Schneider, Gerald J; Schneider, Harald; Staringer, Simon

    2012-07-01

    SPHERES is a third-generation neutron backscattering spectrometer, located at the 20 MW German neutron source FRM II and operated by the Jülich Centre for Neutron Science. It offers an energy resolution (fwhm) better than 0.65 μeV, a dynamic range of ± 31 μeV, and a signal-to-noise ratio of up to 1750:1.

  2. Labyrinthe der Straflosigkeit : Frauenmorde in Ciudad Juárez und extreme Gewalt in Mexiko heute

    OpenAIRE

    Melgar, Lucía

    2011-01-01

    "Der vorliegende Text behandelt die brutalen Frauenmorde (feminicidio), die seit 1993 in den mexikanischen Grenzstädten Ciudad Juärez und Chihuahua stattfinden, als extremes Beispiel für misogyne Gewalt und Verletzung der Menschenrechte. Die Nichtverfolgung der Täter und die damit verbundene Straflosigkeit sowie die Normalisierung von Gewalt gingen der aktuellen Toleranz von Gewalt im mexikanischen 'Drogenkrieg' voraus. Die Auflagen, die der Interamerikanische Gerichtshof für Menschenrechte d...

  3. Collaborative tools for an institutional repository - JuSER, pubdb and all that...

    OpenAIRE

    Wagner, Alexander

    2013-01-01

    This talk gives an overview of the collaborative featrues of JuSER and it's sister systems. After a short introduction of the publications database and the institutional repository, and why they should interact, the main topic are the private collections, known in Jülich as institute collections, and how they can be used in a scientific publication workflow. Input routines are outlined with a special emphasise on the possiblity to import data. Finally a short introduction to groups and basket...

  4. Embers of society: Firelight talk among the Ju/’hoansi Bushmen

    OpenAIRE

    Wiessner, Polly W.

    2014-01-01

    Control of fire and the capacity for cooking led to major anatomical and residential changes for early humans, starting more than a million years ago. However, little is known about what transpired when the day was extended by firelight. Data from the Ju/’hoan hunter-gatherers of southern Africa show major differences between day and night talk. Day talk centered on practicalities and sanctioning gossip; firelit activities centered on conversations that evoked the imagination, helped people r...

  5. The Mid-infrared Evolution of the FU Orionis Disk

    Science.gov (United States)

    Green, Joel D.; Jones, Olivia C.; Keller, Luke D.; Poteet, Charles A.; Yang, Yao-Lun; Fischer, William J.; Evans, Neal J., II; Sargent, Benjamin A.; Rebull, Luisa M.

    2016-11-01

    We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer-IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ˜14%. We find that this decrease in luminosity occurs only at wavelengths ≲20 μm. In particular, the continuum shortward of the silicate emission complex at 10 μm exhibits a ˜12% (˜3σ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μm continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ˜12-14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region.

  6. Designing of Ground Truth Annotated DBT-TU-JU Breast Thermogram Database towards Early Abnormality Prediction.

    Science.gov (United States)

    Bhowmik, Mrinal Kanti; Gogoi, Usha Rani; Majumdar, Gautam; Bhattacharjee, Debotosh; Datta, Dhritiman; Ghosh, Anjan Kumar

    2017-08-17

    The advancement of research in a specific area of clinical diagnosis crucially depends on the availability and quality of the radiology and other test related databases accompanied by ground truth and additional necessary medical findings. The paper describes the creation of the Department of Biotechnology-Tripura University-Jadavpur University (DBT-TU-JU) breast thermogram database. The objective of creating the DBT-TU-JU database is to provide a breast thermogram database that is annotated with the ground truth images of the suspicious regions. Along with the result of breast thermography, the database comprises of the results of other breast imaging methodologies. A standard breast thermogram acquisition protocol suite comprising of several critical factors has been designed for the collection of breast thermograms. Currently, the DBT-TU-JU database contains 1100 breast thermograms of 100 subjects. Due to the necessity of evaluating any breast abnormality detection system, this study emphasizes the generation of the ground truth images of the hotspot areas, whose presence in a breast thermogram signifies the presence of breast abnormality. With the generated ground truth images, we compared the results of six state-of-the-art image segmentation methods using five supervised evaluation metrics to identify the proficient segmentation methods for hotspot extraction. Based on the evaluation results, the Fractional-Order Darwinian particle swarm optimization, Region growing, Mean shift and Fuzzy c-means clustering are found to be more efficient in comparison to k-means clustering and Threshold based segmentation methods.

  7. The Impact of FU Orionis Outbursts and the Solar Nebula

    Science.gov (United States)

    Bell, Robbins; Young, Richard E. (Technical Monitor)

    1998-01-01

    Protostellar systems are variable on many timescales. One of the most dramatic forms of variability known to occur in low mass stellar systems is the FU Orionis outburst (Herbig 1977). Throughout a typical outburst lasting several decades, system luminosities may be a hundred times what is typical of the quiesent state. FU Orionis outburst events are thought to have significant impact on the thermal structure of the protosolar nebula; their existence has been used to explain features in the meteoritic record from thermally induced homogenization to the formation of chondrules. Until recently, the magnitude of the likely effect from such outbursts has been largely speculative due to the lack of a detailed understanding of the outburst mechanism. Recent numerical models (Bell\\& Lin 1994) have demonstrated the viability of the observational hypothesis (Hartmann\\& Kenyon 1985) that the radiation observed during outburst is emitted by a luminous circumstellar disk transporting mass at a thousand times the quiesent rate. Light curves and color and line width evolution observed in FU Orionis systems are naturally explained by time dependent outbursting model disks (Bell et al. 1995). The radial temperature structure and shape of the disk during outburst derived from these models may be used to calculate the outburst's expected impact on primitive material at various radii throughout the disk. In this review, we will begin by discussing what is known about the FU Orionis outburst phenomenon from recent observations and theory including statistically deduced outburst timescales and observed peak temperatures. Unless covered by another author, we will discuss the evidence which suggests that outburst radiation is emitted by a circumstellar disk rather than by the star and will briefly review the thermal instability as a mechanism for outburst. We will then report on recent work which investigates the likely heating of solar nebula material due to FU Orionis outbursts

  8. Research on the Surname of Rulers of the State of Ju%莒国族姓考辨

    Institute of Scientific and Technical Information of China (English)

    张富祥

    2015-01-01

    古莒国的历史可以一直推溯到史前,因相传其族出于嬴姓的东夷少昊集团,故后世多称其国为嬴姓。古籍或又称其国为曹姓,实是以曹地为中心的一种地域性的划分,大抵相当于曹氏,不是莒国本来的姓号。史书又明确记载西周以来的莒国为己姓,此说应是有根据的,其根源即在莒国与纪国通婚,相因于古代从母姓之俗,用纪国本来的日名“己”表姓,故有己姓之称。所以,对于古莒国公族的姓这一问题,需要联系中国古代姓氏制度的演变来具体分析,不宜作简单的取舍。%The history of the State of Ju can be traced back to the pre -historical period of the ancient China .Since it is said that the clan of Ju is probably a branch of the Shaohao ethnic group or tribe , it is commonly believed that the rulers of Ju have the ancestral name of Ying .It is also recorded in some ancient books that the rulers of Ju may take the ancestral name of Cao , but this is actually a name geo-graphically derived from the place of Cao where some people of Ju inhabit .Hence, Cao can be seen as the clan name of the rulers of Ju , but not their ancestral name .Furthermore , there is a clear historical record that the rulers of Ju have taken the ancestral name of Ji since the Western Zhou .This seems to be reasonable because people of Ju are intermarried with those of the State of Ji , and according to the ancient tradition of taking the name of the mother , the rulers of Ju are very likely to have the ancestral name of Ji, which is the"day-name"(riming) of the rulers of Ji.Therefore, it is not proper to take a hasty po-sition on the problem of the ancestral name of the rulers of Ju , which shall require specific analysis on the basis of the evolution of the Chinese surname system .

  9. Wavelet transform analysis of electromyography kung fu strikes data.

    Science.gov (United States)

    Neto, Osmar Pinto; Marzullo, Ana Carolina de Miranda

    2009-11-01

    In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP) values instead of root mean square (rms) values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF). EMG data of the deltoid anterior (DA), triceps brachii (TB) and brachioradialis (BR) muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023) for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007) for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners. Key PointsThe results show higher muscle activity and lower electromyography median frequencies for strikes with impact compared to strikes without.SSP results presented higher sensitivity and lower inter-subject coefficient of variations than rms results.Kung Fu palm strikes with impact may present better motor units' synchronization than strikes without.

  10. Immediate effect of Fu's subcutaneous needling for low back pain

    Institute of Scientific and Technical Information of China (English)

    FU Zhong-hua; CHEN Xin-yuan; LU Li-juan; LIN Jian; XU Jian-guo

    2006-01-01

    @@ The traditional Chinese acupuncture has been reported to alleviate pain and is widely accepted as a complement therapy for pain relief in the world.1In 1996, a novel acupuncture strategy, Fu's subcutaneous needling (FSN), was developed from the traditional Chinese acupuncture, but quite different from it.2 In FSN, needles are penetrated and swayed in the subcutaneous layer, but not the muscular layer. The choosing of its insertion points doesn't obey the principles of traditional Chinese medicine. To date, FSN has been widely used by clinicians in China for its good job in pain management though the systemic and rigorous studies are still lack.

  11. 一款音色迷人de功放(Fu-5乙类)

    Institute of Scientific and Technical Information of China (English)

    师敬之; 汪卸言

    2009-01-01

    采用Fu-7作推挽激励。Fu-5推挽输出,老牌的Fu-5(原称805)是功放三极管,常规的屏压都设为1250V-1550V之间,栅负压取0~16V。广泛用于无线电短波通信发射机的功放。

  12. FuGEFlow: data model and markup language for flow cytometry.

    Science.gov (United States)

    Qian, Yu; Tchuvatkina, Olga; Spidlen, Josef; Wilkinson, Peter; Gasparetto, Maura; Jones, Andrew R; Manion, Frank J; Scheuermann, Richard H; Sekaly, Rafick-Pierre; Brinkman, Ryan R

    2009-06-16

    Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE) formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. We used the MagicDraw modelling tool to design a UML model (Flow-OM) according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML). We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow), which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets. Additional project documentation, including

  13. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression.

    Science.gov (United States)

    Wang, Weicheng; Guo, Wenjie; Li, Lele; Fu, Zan; Liu, Wen; Gao, Jian; Shu, Yongqian; Xu, Qiang; Sun, Yang; Gu, Yanhong

    2016-12-01

    5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU. Mechanism analysis showed that Andrographolide/5-FU co-treatment elevated apoptosis level of HCT116/5-FUR cells with highly increased level of BAX. By using biotin-Andrographolide pull down and cellular thermal shift assay, we found out that Andrographolide can directly target to BAX. Andrographolide-BAX interaction prevented BAX degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-FU resistance while BAX silence diminished this effect. Further, by analyzing patient samples who received 5-FU involved chemotherapy, we found that expression level of BAX is correlated with PFS. Our results here provide a novel combination treatment strategy, especially for patients with 5-FU-resistant tumors expressing low level of BAX. Meanwhile, we also proposed that BAX expression may be a predicted and prognosis marker of 5-FU involved chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. FuGEFlow: data model and markup language for flow cytometry

    Directory of Open Access Journals (Sweden)

    Manion Frank J

    2009-06-01

    Full Text Available Abstract Background Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. Methods We used the MagicDraw modelling tool to design a UML model (Flow-OM according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML. We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. Results The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow, which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets

  15. El papel del narcotráfico en los feminicidios de Ciudad Juárez

    OpenAIRE

    Gallur Santorum, Santiago

    2010-01-01

    International audience; Durante más de quince años las autoridades del estado de Chihuahua, han negado categóricamente que el narcotráfico tuviera relación alguna con los asesinatos y desapariciones de mujeres en Ciudad Juárez. Sin embargo, a pesar de los esfuerzos de las autoridades en invisibilizar todas las pruebas relevantes que demuestran esta hipótesis, investigadores, organizaciones y familiares de víctimas, han aportado pruebas que sacan a la luz las negligencias, la corrupción y la i...

  16. El papel del narcotráfico en los feminicidios de Ciudad Juárez

    OpenAIRE

    Gallur Santorum, Santiago

    2010-01-01

    International audience; Durante más de quince años las autoridades del estado de Chihuahua, han negado categóricamente que el narcotráfico tuviera relación alguna con los asesinatos y desapariciones de mujeres en Ciudad Juárez. Sin embargo, a pesar de los esfuerzos de las autoridades en invisibilizar todas las pruebas relevantes que demuestran esta hipótesis, investigadores, organizaciones y familiares de víctimas, han aportado pruebas que sacan a la luz las negligencias, la corrupción y la i...

  17. Ciudad, espacio y ceguera en ciudad Juárez México

    OpenAIRE

    María E. Vega Ocampo

    2015-01-01

    En el norte de México en la frontera con Estados Unidos, en ciudad Juárezla comunidad ciega mantiene en nuestros días una ausencia participativa en lo cotidiano; la estructura urbana de poca inclusión los lleva a crear alternativas para su movilidad. El presente artículo tiene por objetivo comprender y analizar cómo es la interacción social y espacial de las/los ciegos en una ciudad deshabilitada para su movilidad. Se utilizó un enfoque cualitativo empleando como estrategias de re...

  18. Exploring the efficacy of an environmental health intervention in Ciudad Juárez, Mexico.

    Science.gov (United States)

    Hernández, Alma A; Grineski, Sara E

    2010-01-01

    This study explores the efficacy of an environmental health intervention in several poor colonias in Ciudad Juárez (Mexico). Parents of children with respiratory problems were given environment-friendly products intended to replace hazardous products used in the home, as well as information about environmental health. Parents were surveyed before and after to measure the effectiveness of the intervention and to gauge perceptions. There was a significant reduction in hazardous chemical use (eg, cleaning products and pesticides) and breathing problems. While the intervention focused on changing in-home behaviors, open-ended responses revealed that parents were most concerned about outdoor environmental conditions over which they had less control.

  19. Medio ambiente y servicios urbanos en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Héctor Padilla Delgado

    2009-01-01

    Full Text Available En este trabajo se pretende mostrar el escenario del medio ambiente y los servicios urbanos en Ciudad Juárez durante los años ochenta. Inicia con un esbozo sobre la problemática ambiental de las ciudades fronterizas. Continúa con una descripción de los problemas ambientales y de los servicios urbanos, en particular del agua y drenaje. Concluye con un comentario sobre los efectos que en la salud de los habitantes pueden asociarse al deterioro del medio ambiente.

  20. Tri vrste socijalnih organizacija na otočju jugoistočne Azije

    OpenAIRE

    1991-01-01

    U članku se raspravljaju Morganove, više od stotinu godina stare, teze o terminologiji srodstva. Morgan svoje zaključke nije izvodio ne temelju historijskih i genetičkih dodira među narodima već na temelju karaktera socijalne organizacije. Njegove teze do sada nisu bile raspravljane ni osporavane ali ih autor u ovome radu ocjenjuje kao etnološke greške. Raspravljaju se i neke postavke E. Leacha. Donose i nove spoznaje autora o tipovima socijalne organizacije na otočju jugoistočne Azije....

  1. Medio ambiente y servicios urbanos en Ciudad Juárez

    OpenAIRE

    Héctor Padilla Delgado

    2009-01-01

    En este trabajo se pretende mostrar el escenario del medio ambiente y los servicios urbanos en Ciudad Juárez durante los años ochenta. Inicia con un esbozo sobre la problemática ambiental de las ciudades fronterizas. Continúa con una descripción de los problemas ambientales y de los servicios urbanos, en particular del agua y drenaje. Concluye con un comentario sobre los efectos que en la salud de los habitantes pueden asociarse al deterioro del medio ambiente.

  2. El problema de la vivienda en Ciudad Juárez: los asentamientos humanos irregulares

    OpenAIRE

    Bertha Caraveo C.

    2009-01-01

    El presente artículo pretende plantear y explicar mediante un análisis exhaustivo el problema de la vivienda en Ciudad Juárez, ya que a raíz de este problema se originan diversos problemas sociales los cuales son explicados en la redacción del presente documento haciendo mención de los más destacados en la actualidad como lo son la incapacidad económica en la adquisición de las viviendas, debido a los bajos niveles de ingreso que perciben los individuos que residen en esta Ciudad, así como el...

  3. USTVARJALNOST UČENCEV 4. RAZREDA NA PODROČJU KOMPONIRANJA MELODIJ

    OpenAIRE

    Plazovnik, Mateja

    2013-01-01

    Dejavnost »komponiranja«, v smislu ustvarjanja ter zapisovanja melodije k danemu besedilu, ni pogosto vključena v pouk glasbene vzgoje v osnovnošolskem izobraževanju. Z namenom proučiti ustvarjalne sposobnosti četrtošolcev na tem področju, smo oblikovali tri delavnice, ki so potekale na OŠ Neznanih talcev Dravograd. V delavnicah je sodelovalo 18 učencev iz četrtih razredov, in sicer 9 učencev, ki obiskuje glasbeno šolo in 9 učencev, ki glasbene šole ne obiskuje. Naš sekundarni namen je bil pr...

  4. TRENDI NA PODROČJU CELOVITIH INFORMACIJSKIH REŠITEV (ERP)

    OpenAIRE

    Bednjanič, Aljaž

    2012-01-01

    V diplomskem seminarju so predstavljeni trendi na področju rešitev ERP. Ponudniki rešitev ERP nenehno spreminjajo in dopolnjujejo svoje produkte ter jim dodajajo nove funkcionalnosti. Predstavljeni so naslednji trendi: x-ERP, zunanje izvajanje rešitev ERP, rešitev ERP kot storitev (SaaS ERP), ERP v oblaku in mobilni dostop. Zagotovo je najzanimivejša novost ERP v oblaku. Ta nudi številne prednosti, a obstaja veliko vprašanj, povezanih z varnostjo podatkov v oblaku. Pogledali smo, kako je z zu...

  5. Turismo y estructura territorial en Ciudad Juárez, México

    Directory of Open Access Journals (Sweden)

    Oswaldo Gallegos

    2004-01-01

    Full Text Available Este trabajo muestra un panorama de la estructura territorial del turismo en Ciudad Juárez, Chihuahua, México. El estudio se divide en dos apartados: en el primero se hacen las precisiones conceptuales pertinentes y se sintetizan los eventos históricos representativos del turismo en la frontera norte de México; en el segundo se analizan algunos componentes de la estructura territorial referida, tales como los atractivos que posibilitan la actividad turística, el uso del suelo, los vínculos de comunicación y los flujos de visitantes.

  6. WAVELET TRANSFORM ANALYSIS OF ELECTROMYOGRAPHY KUNG FU STRIKES DATA

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Miranda Marzullo

    2009-11-01

    Full Text Available In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP values instead of root mean square (rms values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF. EMG data of the deltoid anterior (DA, triceps brachii (TB and brachioradialis (BR muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023 for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007 for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners

  7. Force, reaction time, and precision of Kung Fu strikes.

    Science.gov (United States)

    Neto, Osmar Pinto; Bolander, Richard; Pacheco, Marcos Tadeu Tavares; Bir, Cynthia

    2009-08-01

    The goal was to compare values of force, precision, and reaction time of several martial arts punches and palm strikes performed by advanced and intermediate Kung Fu practitioners, both men and women. 13 Kung Fu practitioners, 10 men and three women, participated. Only the men, three advanced and seven intermediate, were considered for comparisons between levels. Reaction time values were obtained using two high speed cameras that recorded each strike at 2500 Hz. Force of impact was measured by a load cell. For comparisons of groups, force data were normalized by participant's body mass and height. Precision of the strikes was determined by a high speed pressure sensor. The results show that palm strikes were stronger than punches. Women in the study presented, on average, lower values of reaction time and force but higher values of precision than men. Advanced participants presented higher forces than intermediate participants. Significant negative correlations between the values of force and precision and the values of force and reaction time were also found.

  8. The Mid-Infrared Evolution of the FU Orionis Disk

    CERN Document Server

    Green, Joel D; Keller, Luke D; Poteet, Charles A; Yang, Yao-Lun; Fischer, William J; Evans, Neal J; Sargent, Benjamin A; Rebull, Luisa M

    2016-01-01

    We present new SOFIA-FORCAST observations obtained in Feburary 2016 of the archetypal outbursting low mass young stellar object FU Orionis, and compare the continuum, solid state, and gas properties with mid-IR data obtained at the same wavelengths in 2004 with Spitzer-IRS. In this study, we conduct the first mid-IR spectroscopic comparison of an FUor over a long time period. Over a 12 year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ~ 14%. We find that this decrease in luminosity occurs only at wavelengths < 20 microns. In particular, the continuum short ward of the silicate emission complex at 10 microns exhibits a ~ 12% (~ 3 sigma) drop in flux density, but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 microns continues to be consistent with unprocessed grains...

  9. Usporedna analiza sustava za 3D digitalizaciju u području stomatološke protetike

    OpenAIRE

    Budak, Igor; Trifkovic, Branka; Puskar, Tatjana; Vukelic, Djordje; Vucaj-Cirilovic, Viktorija; Hodolic, Janko; Todorovic, Aleksandar

    2013-01-01

    Među modernim inženjerskim tehnologijama koje su pronašle široku primjenu u području stomatologije, jedna od najčešće korištenih je 3D digitalizacija. Ovaj se rad bavi primjenom sustava za 3D digitalizaciju u području stomatološke protetike i pokušava doprinijeti u tom području kroz usporednu analizu ove vrste sustava. Posebna pažnja je usmjerena na ekstra-oralne sustave 3D digitalizacije i među njima na ne-specijalizirane stomatološke sustave 3D digitalizacije. Osim općeg pregleda i analize ...

  10. Transfrontera Crimes: Representations of the Juárez Femicides in Recent Fictional and Non-Fictional Accounts

    Directory of Open Access Journals (Sweden)

    Marietta Messmer

    2012-05-01

    Full Text Available In her article, Marrietta Messmer discusses the representation of the Juárez femicides and their traumatizing effects on the Juárez/El Paso community in four recently published accounts: Teresa Rodriguez's journalistic account The Daughters of Juarez (2007, the documentary Señorita Extraviada (2001 directed by Lourdes Portillo, the feature film Bordertown (2006, directed by Gregory Nava, and Alicia Gaspar de Alba's mystery novel Desert Blood: The Juárez Murders (2005. More specifically, she analyzes the degree to which these sources regard the femicides not merely as a Mexican problem but as a structural and highly significant transborder issue that has its roots in the region's current political and economic developments, as well as its pervasive social and cultural changes.

  11. Identificación de Chlamydophila abortus en un aborto ovino en Almoloya de Juárez, México

    Directory of Open Access Journals (Sweden)

    Edgardo Soriano-Vargas

    2011-11-01

    Full Text Available ResumenSe identificó la presencia de Chlamydophila abortus en un aborto ovino procedente de Almoloya de Juárez, México.SummaryChlamydophila abortus was identified in an ovine aborted fetus from Almoloya de Juárez, México

  12. Turismo industrial: oportunidades y retos dentro del sector de manu- factura en Ciudad Juárez

    OpenAIRE

    Francisco Arturo Bribiescas Silva; Ignacio Romero Magaña; Emmanuel García Uribe

    2015-01-01

    Turismo Industrial, tema relevante dentro de la región fronteriza Ciudad Juá-rez-El Paso, donde la Industria de manufactura tiene gran dinamismo eco-nómico, y se visualizan expectativas y propuestas innovadoras a este sector. Este trabajo es una exploración de las oportunidades y retos de la industria manufacturera instalada en Ciudad Juárez para desarrollar actividades de turismo industrial en sus instalaciones. La información se obtuvo a través de entrevistas a profundidad con 15 gerentes d...

  13. A new species of Bolitoglossa (Amphibia, Caudata) from the Sierra de Juárez, Oaxaca, Mexico.

    Science.gov (United States)

    Rovito, Sean M; Parra-Olea, Gabriela; Lee, Dana; Wake, David B

    2012-01-01

    We describe a new species of Bolitoglossa (Nanotriton) from the Sierra de Juárez and Sierra Mixe of Oaxaca, Mexico. Bolitoglossa chinantecasp. n. is distinguished from the three other species in the subgenus Nanotriton by its more robust body, by having substantial numbers of maxillary teeth and differences in relative head width, foot width, and limb length. The new species occurs in sympatry with Bolitoglossa (Nanotriton) rufescens at the type locality. The description of another species of salamander from the Sierra de Juárez is noteworthy, given the already high plethodontid salamander species richness of the region.

  14. Embers of society: Firelight talk among the Ju/’hoansi Bushmen

    Science.gov (United States)

    Wiessner, Polly W.

    2014-01-01

    Much attention has been focused on control of fire in human evolution and the impact of cooking on anatomy, social, and residential arrangements. However, little is known about what transpired when firelight extended the day, creating effective time for social activities that did not conflict with productive time for subsistence activities. Comparison of 174 day and nighttime conversations among the Ju/’hoan (!Kung) Bushmen of southern Africa, supplemented by 68 translated texts, suggests that day talk centers on economic matters and gossip to regulate social relations. Night activities steer away from tensions of the day to singing, dancing, religious ceremonies, and enthralling stories, often about known people. Such stories describe the workings of entire institutions in a small-scale society with little formal teaching. Night talk plays an important role in evoking higher orders of theory of mind via the imagination, conveying attributes of people in broad networks (virtual communities), and transmitting the “big picture” of cultural institutions that generate regularity of behavior, cooperation, and trust at the regional level. Findings from the Ju/’hoan are compared with other hunter-gatherer societies and related to the widespread human use of firelight for intimate conversation and our appetite for evening stories. The question is raised as to what happens when economically unproductive firelit time is turned to productive time by artificial lighting. PMID:25246574

  15. Embers of society: Firelight talk among the Ju/'hoansi Bushmen.

    Science.gov (United States)

    Wiessner, Polly W

    2014-09-30

    Much attention has been focused on control of fire in human evolution and the impact of cooking on anatomy, social, and residential arrangements. However, little is known about what transpired when firelight extended the day, creating effective time for social activities that did not conflict with productive time for subsistence activities. Comparison of 174 day and nighttime conversations among the Ju/'hoan (!Kung) Bushmen of southern Africa, supplemented by 68 translated texts, suggests that day talk centers on economic matters and gossip to regulate social relations. Night activities steer away from tensions of the day to singing, dancing, religious ceremonies, and enthralling stories, often about known people. Such stories describe the workings of entire institutions in a small-scale society with little formal teaching. Night talk plays an important role in evoking higher orders of theory of mind via the imagination, conveying attributes of people in broad networks (virtual communities), and transmitting the "big picture" of cultural institutions that generate regularity of behavior, cooperation, and trust at the regional level. Findings from the Ju/'hoan are compared with other hunter-gatherer societies and related to the widespread human use of firelight for intimate conversation and our appetite for evening stories. The question is raised as to what happens when economically unproductive firelit time is turned to productive time by artificial lighting.

  16. Integrated river basin management of Južna Morava River

    Directory of Open Access Journals (Sweden)

    Borisavljević Ana

    2012-01-01

    Full Text Available In the last decade in particular, Serbia encountered the problems of drinking water supply, which influenced the perception of professional public about the water crisis but also started more intensive work on water resource perseverance as well as the implementation of European Water Directive. One of the main demands of the Directive focuses on integrated river basin management (IRBM, which is a complex and a large task. The need to collect data on water quality and quantity, specific and key issues of water management in Južna Morava river basin, pressures on river ecosystem, flood risks and erosion problems, cross-border issues, socioeconomic processes, agricultural development as well as protected areas, and also to give the measures for solving problems and pressures recognized in the basin, is undisputable. This paper focuses on detailed analysis of specific pressures on river ecosystem and composition of recommendations for integrated management of Južna Morava river basin as cross-border river basin, taking into the account European experiences in IRBM. [Projekat Ministarstva nauke Republike Srbije, br. 43007: Istraživanje klimatskih promena na životnu sredinu - praćenje uticaja, adaptacija i ublažavanje, podprojekat br. 9: Učestalost bujičnih poplava, degradacija zemljišta i voda kao posledica globalnih promena

  17. Low Angle Contact Between the Oaxaca and Juárez Terranes Deduced From Magnetotelluric Data

    Science.gov (United States)

    Arzate-Flores, Jorge A.; Molina-Garza, Roberto; Corbo-Camargo, Fernando; Márquez-Ramírez, Víctor

    2016-10-01

    We present the electrical resistivity model along a profile perpendicular to the Middle America trench in southern Mexico that reveals previously unrecognized tectonic features at upper to mid-crustal depths. Our results support the hypotheses that the upper crust of the Oaxaca terrane is a residual ~20 km thick crust composed by an ~10 km thick faulted crustal upper layer and an ~10 km thick hydrated and/or mineralized layer. Oaxaca basement overthrust the younger Juárez (or Cuicateco) terrane. The electrical resistivity model supports the interpretation of a slab subducting at a low angle below Oaxaca. Uplift in the Oaxaca region appears to be related to fault reactivation induced by low angle subduction. In the Juárez terrane, isostatic forces may contribute to uplift because it is largely uncompensated. In the Sierra Madre del Sur, closer to the coast, uplift is facilitated by slab-dehydration driven buoyancy. Both gravity and resistivity models are consistent with a thinned upper crust in the northeast end of the profile.

  18. Chromosomal imbalance maps of human 5FU-resistant colorectal cancer cell lines: implications in the analysis of 5FU-acquired resistance mechanisms.

    Science.gov (United States)

    Plasencia, C; Rooney, P H; Taron, M; Martinez-Balibrea, E; McLeod, H L; Abad, A

    2003-05-01

    Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors. Overexpression of TS has been correlated to 5-fluorouracil (5FU)-resistance. Because 5FU still remains a basic component of the treatment of colorectal cancer, circumvention of resistance is of vital importance. A panel of sensitive (HT29 and LoVo) and 5FU-resistant colorectal cancer cell lines (HT29-5FUR and LoVo-5FUR) were subjected to comparative genomic hybridization (CGH) analysis to identify possible amplified/deleted regions associated with 5FU-resistance in colon tumours. We have identified chromosomal gains at 5p, 6, 7p, 7q and 8q and one loss at 3q in 5FU-resistant cells as compared to corresponding sensitive cell lines. Neither chromosomal gains at 18p nor gene amplification of TS were observed in our resistant cell lines although an overexpression of TS gene exists (at mRNA level) in these cell lines as compared with corresponding parental cells. Most of the chromosomal gains identified in this study occur frequently in sporadic colorectal tumours and has been associated to a poor prognosis and a greater progression of the tumour and could be related to a worse chemotherapy response. The chromosomal imbalance profile detected in 5FU-resistant cell lines should provide a basis for interpreting mechanisms of 5FU-resistance in colorectal cancer and also possibly in other tumours treated with this agent. This study also identified new genes potentially implicated in 5FU-resistance and suggests new targets that could be useful for the chemotherapy treatment of colorectal cancer.

  19. Adenovirus KH901 promotes 5-FU antitumor efficacy and S phase in LoVo cells.

    Science.gov (United States)

    Peng, Wei; Li, Jin; Yin, X G; Xu, J F; Cheng, L Z

    2012-06-01

    A combination of oncolytic and chemotherapeutic agents has been used to kill cancer cells. However, the effect of oncolytic adenoviruses on the cell cycle remains to be determined. Cytotoxicity assays were performed to determine cell death in cells treated with 5-fluorouracil (5-FU) alone or in combination with the oncolytic adenovirus KH901. Dynamic changes in the cell cycle, cell proliferation, and apoptosis-related proteins including p-AKT, Bcl-2, Bax, and caspase 3 were investigated after treatment with 5-FU with or without KH901. A higher proportion of S-phase cells were observed after treatment with KH901 and 5-FU than with 5-FU alone. p-AKT, Bcl-2, and Bax expression was increased upon treatment with KH901, whereas the expression of caspase-3 was not induced upon treatment with KH901 with or without 5-FU. KH901 exhibited significant potential as an oncolytic adenovirus and increased cell death in combination with 5-FU in LoVo cells, as compared to 5-FU alone. In conclusion, KH901 stimulates LoVo cells to enter the S-phase by activation of p-AKT, which could partly explain its synergistic effect with 5-FU on LoVo cell cytotoxicity.

  20. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

    NARCIS (Netherlands)

    Reerink, O; Mulder, NH; Szabo, BG; Hospers, GAP

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU

  1. Mitomycin-C and 5- FU in ophthalmology: review article

    Directory of Open Access Journals (Sweden)

    M Jabbarvand Behrouz

    2009-03-01

    Full Text Available "nThe response of living tissues to the surgical trauma is associated with varying degrees of tissue repair and involves two distinct processes including replacement and regeneration. Replacement results in scar tissue formation instead of restoration of the normal architecture. However, regeneration leads to restoration of the original architecture leaving no sign of injury. Anti-proliferative agents are used to inhibit tissue responses to surgical trauma. Among them mitomycin- C and 5- FU had gained increasing applications in ophthalmic surgeries, including filtering glaucoma surgeries, laser vision correction with excimer laser by ablative surface refractive surgery, reconstructive surgeries for ocular surface disorders and removal of neoplastic tissues and secondary operations on nasolacrimal ducts. In this review article, the various aspects of applications of these agents including their mechanism of action, function, mode of application and complications in different ophthalmology fields are discussed.

  2. Iedzīvotāju ienākuma nodokļa ietekme uz iedzīvotāju dzīves līmeni

    OpenAIRE

    Putniņš, Dairis

    2010-01-01

    Diplomdarba tēma „Iedzīvotāju ienākuma nodokļa ietekme uz iedzīvotāju dzīves līmeni” šobrīd sabiedrībā ir aktuāla, jo iedzīvotāju ienākuma nodoklis ir svarīga ienākumu sastāvdaļa gan Latvijas valsts budžetā, gan arī pašiem iedzīvotājiem. Visi nodokļi Latvijā tiek balstīti uz vienotu nodokļu politiku, kas ir viens no svarīgākajiem instrumentiem valsts ekonomikas attīstības veidošanā un iedzīvotāju dzīves līmeņa paaugstināšanā. Šobrīd priekšroka gan tiek dota tam, lai tiktu palielināti budžeta ...

  3. Una poética de la memoria: la poesía de Rafael Juárez

    NARCIS (Netherlands)

    Valdivia, P.

    2010-01-01

    In this essay, the intellectual and literary foundations of Rafael Juárez’s poetic discourse are studied in depth. Such assessment is specifically carried out taking as an example his poetry collection entitled Aulaga. From the theoretical framework provided by Paul Ricoeur in his works about the no

  4. Teadlased: Juštšenkole anti väga puhast mürki

    Index Scriptorium Estoniae

    2009-01-01

    Suurbritannia ajakiri Lancet väidab, et dioksiin, mis põhjustas Ukraina presidendile Viktor Juštšenkole 2004. aastal tõsise mürgituse, oli nii puhas, et pidi pärinema otse laboratooriumist, kuna loodusest ei saa puhast dioksiini

  5. Una poética de la memoria: la poesía de Rafael Juárez

    NARCIS (Netherlands)

    Valdivia, P.

    2010-01-01

    In this essay, the intellectual and literary foundations of Rafael Juárez’s poetic discourse are studied in depth. Such assessment is specifically carried out taking as an example his poetry collection entitled Aulaga. From the theoretical framework provided by Paul Ricoeur in his works about the

  6. Hayabusa2 mission target asteroid (162173) 1999 JU_3: Searching for the object's spin-axis orientation

    NARCIS (Netherlands)

    Müller, T.; Durech, J.; Mueller, M.; Kiss, C.; Vilenius, E.; Ishiguro, M.

    2014-01-01

    The JAXA Hayabusa2 mission was approved in 2011 with launch planned for late 2014. Arriving at the asteroid (162173) 1999 JU_3 in 2018, it will survey it, land, and obtain surface material, then depart in late 2019, and return to the Earth in December 2020. We observed the near-Earth asteroid 1999 J

  7. Hayabusa2 mission target asteroid (162173) 1999 JU_3: Searching for the object's spin-axis orientation

    NARCIS (Netherlands)

    Müller, T.; Durech, J.; Mueller, M.; Kiss, C.; Vilenius, E.; Ishiguro, M.

    2014-01-01

    The JAXA Hayabusa2 mission was approved in 2011 with launch planned for late 2014. Arriving at the asteroid (162173) 1999 JU_3 in 2018, it will survey it, land, and obtain surface material, then depart in late 2019, and return to the Earth in December 2020. We observed the near-Earth asteroid 1999

  8. Algumas anotações sobre o juízo em Hume

    Directory of Open Access Journals (Sweden)

    Evandro C. Godoy

    2011-08-01

    Full Text Available O filósofo escocês David Hume produziu uma teoria acerca dos processos cognitivos humanos que tem vasta influência na contemporaneidade, sobretudo na Filosofia da Mente e na Epistemologia. Desta influência relevante decorre a necessidade de interpretações sérias e cautelosas, ainda que isto demande muito cuidado com a terminologia peculiar de sua obra, que pode levar a comparações mal embasadas com outros autores. Na intenção de colaborar para o esclarecimento e qualificação do debate acerca das contribuições de Hume, o presente texto pretende apresentar uma visão resumida, mas geral da sua filosofia teórica, de modo a deixar claro que i as relações de ideias descritas na filosofia do autor não constituem, por si só, uma teoria do juízo; ii sua concepção de juízo deve ser buscada na sua explicação da crença e iii apesar da marcante influência de seus antecessores (principalmente de Locke e Descartes, sua filosofia apresenta uma teoria do juízo original e repleta de particularidades. Abstract The Scottish philosopher David Hume produced a theory about human cognitive processes that has widespread influence in contemporary, especially in the Philosophy of Mind and Epistemology. This important influence demands serious and cautious interpretations, and it burdens indeed care with the peculiar terminology of his work in order to avoid ill-grounded comparisons with other authors. Intending to contribute to clarification and qualification of the debate about the contributions of Hume, this text presents a general idea, though resumed, of his theoretical philosophy in order to make clear that: i the relations of ideas described in the philosophy of the author are not, by itself, a theory of judgment; ii his conception of judgment must be searched in his explanation of belief and iii despite the remarkable influence of his predecessors (Descartes and Locke especially, his philosophy has a full detailed and original theory

  9. Impactos de la maquila en el medio ambiente de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Centro de Estudios Regionales y Comunicación Alternativa (CERCA

    2009-01-01

    Full Text Available En el presente trabajo analizamos, de manera general, los cambios que ha generado el proyecto maquilador en Ciudad Juárez. Primero observamos su efecto sobre el crecimiento de la mancha urbana, la dotación de servicios, etcétera, su repercusión en el medio ambiente y las condiciones de vida de la población juarense. Nos planteamos, además, ubicar los principales problemas causados por el desarrollo de la industria maquiladora, particularmente en lo relativo a los desechos tóxicos y nucleares, así como apuntar la tendencia del proyecto económico-urbano que ésta ha impuesto en nuestra ciudad, para concluir con una breve presentación de las reacciones populares y algunas propuestas ante el problema. Asimismo, exponemos los problemas de contaminación que resultan de otras actividades no vinculadas a la industria maquiladora.

  10. Homicidio masculino en Ciudad Juárez. Costos de las masculinidades subordinadas

    Directory of Open Access Journals (Sweden)

    Salvador Cruz

    2011-01-01

    Full Text Available El homicidio masculino agudizado en Ciudad Juárez en los años 2008 y 2009, con casi cuatro mil asesinatos, constituye la expresión más evidente de la violencia urbana. Dicha violencia ha tomado rostro en hombres, en su mayoría jóvenes y marginados. Los datos muestran un comportamiento del homicidio doloso asimilado a significados relacionados con la masculinidad más tradicional, cuyo costo recae en la vida misma. Se observa a través de los escenarios, los horarios en que ocurren los eventos y las formas de ejecución, que esta práctica delictiva puede ser comprendida como una actividad masculina que explota una subjetividad proclive a la violencia y que reproduce las asimetrías de género y significados asociados a la dicotomía masculino-femenino.

  11. Street Art at the Border: Representations of Violence and Death in Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Diana Alejandra SILVA LONDOÑO

    2016-01-01

    Full Text Available El objetivo de este artículo es realizar una lectura interpretativa de las tramas de sentido de la violencia y la muerte violenta en Ciudad Juárez, a partir de su representación en el arte urbano. Por medio de entrevistas en profundidad, observación participante, recorridos urbanos y regis - tro fotográf ico de la producción artística de los colectivos de arte urbano fronterizo se explora cómo las/os jóvenes se conciben a sí mismas/os, perciben su experiencia biográf ica y cuáles son sus márgenes de agencia desde las prácticas artísticas en contextos de violencia.

  12. residenciales de madres sin cónyuge en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Claudia Zamorano Villarreal

    2006-01-01

    Full Text Available Se abordarán los itinerarios y las prácticas residenciales de madres sin cónyuge en Ciudad Juárez, ese punto de convergencia de inmigrantes nacionales y capitales internacionales y ahora, una de las más importantes ciudades maquiladoras del país. A partir de 51 historias de vida con trabajadoras de esta industria, se comparan los itinerarios residenciales de familias monoparentales con los de familias biparentales. Esta comparación permite ver las desventajas de las primeras para ingresar al mercado de la vivienda, que no se explican únicamente por factores de orden económico, sino también moral y práctico.

  13. Ciudad Juárez en los sesenta: la estructura urbana en transición

    Directory of Open Access Journals (Sweden)

    Luis Enrique Gutiérrez Casas

    2009-01-01

    Full Text Available El presente trabajo está estructurado de tal forma que puedan cubrirse, de manera general, los distintos aspectos que consideramos explican el problema de la vivienda en Ciudad Juárez. En la primera parte planteamos el problema de la vivienda desde varios aspectos, déficit, bajos salarios y pérdida del poder adquisitivo de los trabajadores, fluctuación del mercado inmobiliario, crecimiento poblacional, cambios en la composición del mercado laboral, flujos migratorios, políticas económicas y de vivienda. En la segunda parte centramos nuestro análisis en los AHI. Sus rasgos principales son las formas irregulares de apropiación del suelo urbano, la autoconstrucción y la introducción ilegal de servicios públicos, entre otros.

  14. Social acceptability urban form and sustainability in urban neighborhoods in Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Claudia Gabriela Vargas Fernández

    2016-11-01

    Full Text Available In the field of urban planning, questioning around sustainability and the possibility of sustainable urban planning has led to a new set of approaches and discussions that impact studies on urban form and sustainable livelihoods. This approach characterized the work presented by Mike Jenks and Colin Jones (2010, Dimensions of the Sustainable City, where a set of variables are presented about urban sustainability from the neighbourhood level of analysis. In that sense, this article proposes the analysis of three social housing neighborhoods in Ciudad Juárez, Chihuahua, México, integrating aspects of urban form and social acceptability, in order to understand the relationship between the physical and sociocultural dimensions of the concept of urban sustainability.

  15. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Pueyo, Laurent [Johns Hopkins University, Department of Physics and Astronomy, 366 Bloomberg Center 3400 N. Charles Street, Baltimore, MD 21218 (United States); Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil [American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 941 Dennison Building, 500 Church Street, Ann Arbor, MI 48109-1090 (United States); Crepp, Justin [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Parry, Ian [University of Cambridge, Institute of Astronomy, Madingley Road, Cambridge, CB3, OHA (United Kingdom); Beichman, Charles [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91225 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2012-09-20

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  16. 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

    Directory of Open Access Journals (Sweden)

    Shi Huashan

    2010-08-01

    Full Text Available Abstract Background Colorectal peritoneal carcinomatosis (CRPC is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. Methods A biodegradable PEG-PCL-PEG (PECE triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. Results The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Conclusions Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.

  17. Femicídio em Juárez (México

    Directory of Open Access Journals (Sweden)

    Eva Paulino Bueno

    2016-08-01

    Full Text Available O artigo apresenta a situação atual de mulheres operárias   no México, com ênfase na cidade fronteiriça de Juárez, onde há uma incidência altíssima des assassinatos de mulheres. A maioria destas mulheres é torturada e estuprada antes de serem assassinadas. Apesar do fato da humilhação do homem pobre numa cultura que paulatinamente destrói o modelo familiar estável ser um fator para esta violência contra mulheres, a cultura machista é o maior fator parar a esta situação. O artigo traz algumas estatísticas e reflexões sobre o impacto destas mortes na família das vítimas, assim como em toda a sociedade. Abstract: the essay presents the current situation of factry workers in Mexico, with emphasis on the frontier city of Juárez, where there is a very high incidence of murder of women.  Most of these women are tortured and raped before they are killed. Although the humiliation of poor men in a culture that slowly destroys a stable family model is an important factor for violence against women, the machista culture is the biggest factor for this situation.  The article brings some statidstics and reflects on the impact of these deaths on the families of the victims, as well as on the whole society.

  18. Inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803

    Institute of Scientific and Technical Information of China (English)

    Yang Wang; Chang-Lin Li

    2016-01-01

    Objective:To study the inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803.Methods:Gastric cancer cell lines MGC803 were cultured, divided into NC group, 5-Fu group and SB+5-Fu group and treated with different conditions, and then the number of apoptotic cells, the number of invasive cells as well as the expression of proliferation and invasion-related genes were detected.Results:At 6 h, 12 h, 18 h and 24 h after treatment, the number of apoptotic cells of 5-Fu group and SB+5-Fu group was significantly more than that of NC group, the number of invasive cells was significantly less than that of NC group, the number of apoptotic cells of SB+5-Fu group was significantly more than that of 5-Fu group, and the number of invasive cells was significantly less than that of 5-Fu group; mRNA contents of Vav3, PTP1B, GOLPH3, RUNX3, Sipa1, UbcH10, NEDD9, Mig-7, CD157, AEP and Galectin-1 of 5-Fu group and SB+5-Fu group were lower than those of NC group; mRNA contents of Vav3, PTP1B, GOLPH3, UbcH10, NEDD9, Mig-7, CD157, AEP and Galectin-1 of SB+5-Fu group were lower than those of 5-Fu group, and mRNA contents of RUNX3 and Sipa1 were not different from those of 5-Fu group. Conclusion:Compared with single 5-FU treatment, silibinin combined with 5-FU treatment can more effectively promote gastric cancer cell apoptosis, inhibit gastric cancer cell invasion and regulate the expression of proliferation and invasion-related genes.

  19. Dynamisch-optische Oberflächenvermessung des plantaren Fußes

    OpenAIRE

    Schmeltzpfenning, Timo

    2011-01-01

    Dynamisch-optische Oberflächenvermessung des plantaren Fußes Inhalt und Vorgehensweise Die Entwicklung eines zeitauflösenden dreidimensionalen Fußscanners unter Verwendung einer dynamisch-optischen Oberflächenvermessung stellt die primäre Zielsetzung dar. Dieses System wurde anschließend genutzt, um erste Erkenntnisse zur dynamischen Fußformveränderung über den Abrollvorgang zu gewinnen. Die Relevanz der Formveränderung, z.B. für die industrielle Schuhfertigung, wird in der Arbeit...

  20. Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

    Science.gov (United States)

    Wang, Yixin; Li, Jianliang; Li, Yang; Fang, Lichun; Sun, Xiaolong; Chang, Shuang; Zhao, Peng; Cui, Zhizhong

    2016-06-01

    Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

  1. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation

    Science.gov (United States)

    Fu, Y; Yang, G; Zhu, F; Peng, C; Li, W; Li, H; Kim, H-G; Bode, A M; Dong, Z; Dong, Z

    2014-01-01

    Although the rate of development of drug resistance remains very high, 5-fluorouracil (5-Fu) is still the most common chemotherapeutic drug used for the treatment of colon cancer. A better understanding of the mechanism of why cancers develop resistance to 5-Fu could improve its therapeutic effect. Sometimes, antioxidants are used simultaneously with 5-Fu treatment. However, a recent clinical trial showed no advantage or even a harmful effect of combining antioxidants with 5-Fu compared with administration of 5-Fu alone. The mechanism explaining this phenomenon is still poorly understood. In this study, we show that 5-Fu can induce reactive oxygen species-dependent Src activation in colon cancer cells. Mouse embryonic fibroblasts that are deficient in Src showed a clear resistance to 5-Fu, and knocking down Src protein expression in colon cancer cells also decreased 5-Fu-induced apoptosis. We found that Src could interact with and phosphorylate caspase-7 at multiple tyrosine sites. Functionally, the tyrosine phosphorylation of caspase-7 increases its activity, thereby enhancing cellular apoptosis. When using 5-Fu and antioxidants together, Src activation was blocked, resulting in decreased 5-Fu-induced apoptosis. Our results provide a novel explanation as to why 5-Fu is not effective in combination with some antioxidants in colon cancer patients, which is important for clinical chemotherapy. PMID:24407236

  2. NE TIGER Premieres New Hua Fu At Bird’s Nest

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On the evening of September 25, China’s leading luxury fashion brand NE TIGER presented its premiere fashion show of Hua Fu(Chinese national dress) at a concert of superstars from China, Japan and South Korea,

  3. [Professor Xu Fu-song's traditional Chinese medicine protocols for male diseases: A descriptive analysis].

    Science.gov (United States)

    Liu, Cheng-yong; Xu, Fu-song

    2015-04-01

    To analyze the efficacy and medication principles of Professor Xu Fu-songs traditional Chinese medicine (TCM) protocols for male diseases. We reviewed and descriptively analyzed the unpublished complete medical records of 100 male cases treated by Professor Xu Fu-song with his TCM protocols from 1978 to 1992. The 100 cases involved 32 male diseases, most of which were difficult and complicated cases. The drug compliance was 95%. Each prescription was made up of 14 traditional Chinese drugs on average. The cure rate was 32% , and the effective rate was 85%. Professor Xu Fu-song advanced and proved some new theories and therapeutic methods. Professor Xu Fu-song's TCM protocols can be applied to a wide range of male diseases, mostly complicated, and are characterized by accurate differentiation of symptoms and signs, high drug compliance, and excellent therapeutic efficacy.

  4. Asynchronous Sensor fuSion for Improved Safety of air Traffic (ASSIST) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — SSCI proposes to develop, implement and test a collision detection system for unmanned aerial vehicles (UAV), referred to as the Asynchronous Sensor fuSion for...

  5. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients.

    Science.gov (United States)

    Reerink, O; Mulder, N H; Szabo, B G; Hospers, G A P

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU and oxaliplatin. A possible co-medication effect of oxaliplatin is considered, as are the consequences of screening for DPD deficiency.

  6. [Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].

    Science.gov (United States)

    Heluwaert, Frédéric; Santre, Charles; Martin, Claude; Hilleret, Marie-Noëlle; Martin, Denis

    2006-02-01

    5FU is one of the most frequently used antioncogenic and cytostatic drug in digestive oncology. It may cause severe adverse events, such as encephalopathy, possibly based on hyperammoniemia, and may lead to coma. We report here the case of a coma with a favorable outcome following 5FU chemotherapy. As any other etiologic findings came to light, hyperammoniemia was discussed as a credible cause.

  7. Zur Kulturbedeutung von Hooligandiskurs und Alltagsrassismus im Fußballsport

    OpenAIRE

    2007-01-01

    'Dieser Essay diskutiert die Frage nach dem Sinnzusammenhang zwischen rechter Gewalt und Alltagsrassismus in der Fußballwelt. Es wird argumentiert, dass die Betonung des (marginalen) Phänomens des rechten Extremismus und seine Verknüpfung mit Rassismus und Hooliganismus den (weitverbreiteten) Rassismus in den niedrigen Amateurklassen verdeckt. Indem sie ihre moralische Abscheu vor dem Hooliganismus zum Ausdruck bringen, sind Angehörige der Fußballwelt dazu in der Lage, sich symbolisch vom All...

  8. Aspectos epidemiológicos da Leishmaniose Tegumentar Americana no município de Juína, Mato Grosso, Brasil = Epidemiological aspects of American Cutaneous Leishmaniasis in the city of Juína, Mato Grosso state, Brazil

    Directory of Open Access Journals (Sweden)

    França, Eduardo Luzia

    2009-01-01

    Conclusões: a análise dos dados revelou que a Leishmaniose Tegumentar Americana é uma parasitose importante no município de Juína. Os dados sugerem relação com a atividade laboral e um perfil de transmissão predominantemente silvestre, o que deve ser levado em conta ao definir medidas de controle da doença na região

  9. Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seungho [Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of); Ku, Ja-Lok, E-mail: kujalok@snu.ac.kr [Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of)

    2011-08-26

    Highlights: {yields} MELK expression significantly increased when the cells are exposed to radiation or 5-FU. {yields} Suppression of MELK caused cell cycle changes and decrease in proliferation. {yields} Radiation or 5-FU treatment after MELK suppression by siRNA induced growth inhibition. -- Abstract: It was reported that the local recurrence would be caused by cancer stem cells acquiring chemo- and radio-resistance. Recently, one of the potential therapeutic targets for colorectal and other cancers has been identified, which is maternal embryonic leucine zipper kinase (MELK). MELK is known as an embryonic and neural stem cell marker, and associated with the cell survival, cell proliferation, and apoptosis. In this study, SNU-503, which is a rectal cancer cell line, was treated with radiation or 5-fluorouracil (5-FU), and elevation of the MELK expression level was observed. Furthermore, the cell line was pre-treated with small interfering RNA (siRNA) against MELK mRNA before treatment of radiation or 5-FU and its effects on cell cycle and proliferation were observed. We demonstrated that knockdown of MELK reduced the proliferation of cells with radiation or 5-FU treatment. In addition, MELK suppression caused changes in cell cycle. In conclusion, MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU.

  10. Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

    Directory of Open Access Journals (Sweden)

    Mei Peng

    Full Text Available Although 5-fluorouracil (5-Fu combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs, it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group and 92.37% in the 5-Fu+Act-D group (5-Fu group; these rates were not significantly different (P > 0.05. However, the incidence rates of myelosuppression (white blood cell decline, gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea, skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05. The results of this study may provide useful data for the clinical application of tegafur in GTN treatment.

  11. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.

    Science.gov (United States)

    Gmeiner, William H; Trump, Eric; Wei, Cui

    2004-01-01

    FdUMP[N] molecules and conjugates are much more effective at inhibiting the proliferation of human tumor cells than is the widely used anticancer drug 5-fluorouracil (5FU). We have evaluated the inhibition of thymidylate synthase (TS), the extent of DNA damage, cell cycle arrest, and the induction of apoptosis by FdUMP[10] and 5FU in the human colorectal cancer cell line HT29. The magnitude and duration of TS inhibition following exposure of HT29 cells to FdUMP[10] at 1 x 10(-8) M was greater than that which occurred following exposure of these cells to 5FU at 1 x 10(-6) M. FdUMP[10] exposure also resulted in much more extensive DNA damage to HT29 cells than occurred following exposure to 100-fold higher concentrations of 5FU. Although exposure of HT29 cells to both drugs resulted in S-phase arrest, more complete accumulation of cells in S-phase was achieved following FdUMP[10] exposure at much lower drug concentrations. FdUMP[10] was also much more effective at inducing apoptosis in HT29 cells than was 5FU. The results are consistent with FdUMP[10] being much more efficient that 5FU at inducing DNA damage that results in apoptotic cell death in colon cancer cells.

  12. Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines.

    Science.gov (United States)

    Kawabata, Rumi; Oie, Shinji; Takahashi, Masayuki; Kanayama, Hiroomi; Oka, Toshinori; Itoh, Kohji

    2011-06-01

    In this study, we investigated the synergistic mechanism of anti-androgen and 5-fluorouracil (5-FU) combination therapy against castration-resistant prostate cancer (CRPC). Four prostate cancer cell lines, LNCaP, 22Rv1, DU145 and PC3, were examined for their growth dependency on androgens and the insulin-like growth factor 1 (IGF1). We assessed the expression changes of certain growth factor receptors and regulating proteins when treated with 5-FU, and found that 5-FU increased the expression of the IGF-binding protein 3 (IGFBP3). Furthermore, 5-FU inhibited the phosphorylation of Akt and p70 S6K, while the knockdown of IGFBP3 reduced the levels of poly (ADP-ribose) polymerase cleaved by 5-FU in PC3 cells. Therefore, the up-regulation of IGFBP3 by 5-FU not only inhibits cell growth by reducing the IGF1 signal but also induces apoptosis in PC3 cells. The synergistic effect of bicalutamide and 5-FU on 22Rv1 cells was reduced by IGFBP3 gene silencing using small-interfering RNA. These results suggest that the up-regulation of IGFBP3 induced by 5-FU plays an important role in the potent anti-tumor effect of 5-FU combined with anti-androgens on CRPC. Androgen-deprivation therapy combined with 5-FU could therefore be an appropriate therapy for CRPC patients.

  13. Mental health outcomes of Mexico's drug war in Ciudad Juárez: A pilot study among university students.

    Science.gov (United States)

    O'Connor, Kathleen; Vizcaino, Maricarmen; Benavides, Nora A

    2014-03-01

    During the most intense period of armed conflict related to the drug trade in Mexico, forty students attending the Universidad Autónoma de Ciudad Juárez (UACJ) in Ciudad Juárez, Chihuahua, Mexico, were surveyed in this pilot study for symptoms of depression, anxiety and post-traumatic stress using the Harvard Trauma Questionnaire and the Hopkins Symptom Checklist. The percentage of participants who scored positively for symptoms of PTSD depression and anxiety were 32.5%, 35% and 37.5%, respectively. Criteria for post-traumatic stress were analyzed separately. The most frequently-reported traumatic events included extortion or robbery, confinement to home, injury to loved one, being in an armed conflict, witnessing a killing or dead body and being beaten. Trauma events positively associated with depression, anxiety and PTSD symptoms included robbery or extortion, armed conflict situation, exposure to frequent arms fire, and witnessing a killing or dead body.

  14. Juízos e valores morais: a perspectiva de investigação dos modelos organizadores do pensamento

    Directory of Open Access Journals (Sweden)

    Mário Sérgio Vasconcelos

    2010-08-01

    Full Text Available As ideias propostas neste estudo teórico têm como objetivo ampliar as perspectivas de investigação sobre juízos e valores morais. Após uma reflexão crítica sobre teorias que contribuíram com importantes conceitos no campo da Psicologia Moral, foram feitos alguns apontamentos que nos parecem promissores nessa área, tendo por referencial teórico-metodológico a Teoria dos Modelos Organizadores do Pensamento. Essa teoria procura destacar que apenas os recursos cognitivos operatórios não são suficientes para explicar como o sujeito apreende e julga a realidade. Nessa perspectiva, conclui-se como fundamental o papel dos conteúdos na organização das representações mentais relacionadas aos juízos e valores morais.

  15. Turismo industrial: oportunidades y retos dentro del sector de manu- factura en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Francisco Arturo Bribiescas Silva

    2015-01-01

    Full Text Available Turismo Industrial, tema relevante dentro de la región fronteriza Ciudad Juá-rez-El Paso, donde la Industria de manufactura tiene gran dinamismo eco-nómico, y se visualizan expectativas y propuestas innovadoras a este sector. Este trabajo es una exploración de las oportunidades y retos de la industria manufacturera instalada en Ciudad Juárez para desarrollar actividades de turismo industrial en sus instalaciones. La información se obtuvo a través de entrevistas a profundidad con 15 gerentes de las empresas más importantes de esta región. Dentro de los resultados se puede observar que las actividades del turismo industrial son percibidas por los gerentes entrevistados como benéficas y consideradas como una actividad alterna a la manufactura.

  16. Ciudad, espacio y ceguera en ciudad Juárez México / City, Space, and Blindness Juárez, México

    Directory of Open Access Journals (Sweden)

    Maria Esther Vega-Ocampo

    2015-05-01

    Full Text Available Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Cambria;} Resumen. La comunidad ciega en ciudad Juárez Mexico en frontera con Estados Unidos, mantiene en nuestros días una ausencia participativa en lo cotidiano, la estructura urbana de poca inclusión, los lleva crear alternativas para su movilidad. El objetivo  de este estudio es comprender y analizar cómo es la interacción social y espacial del ciego en una ciudad deshabilitada para su movilidad. Se utilizo un enfoque cualitativo que permitiese una observación cercana al grupo mediante entrevistas semi estructurada y observación participante, se escogió a un grupo de jóvenes ciegos que asisten a la Escuela para Ciegos Luis Braille. Se encontró que la ciudad  muestra un reflejo marginal que genera restricciones en su traslado, movilidad y aprendizaje espacial manteniendo una difícil autonomía.   Abstract: The community of visually impaired persons in Ciudad Juarez, Mexico, sitting astride the United States border, is practically absent from the city's day-to-day life. Providing negligible accommodations, Ciudad Juarez is not an inclusive environment and thus the visually impaired must auto-construct their own means of mobility to get out into the broader community they inhabit. The objective of this study is to analyze and understand the social and spacial interaction of the visually impaired in a northern Mexican border city entirely unequipped for them. The study focuses on a group of students at the Luis Braille School for the Blind in Ciudad Juarez, who were interviewed and observed during a prolonged period of time, and concludes that

  17. MOGUĆNOST PRIMJENE MODELA “BALANCED SCORECARD” NA PODRUČJU FINANCIJSKIH INSTITUCIJA: PRIMJER IZ HRVATSKE POSLOVNE PRAKSE

    OpenAIRE

    2000-01-01

    Pozitivni rezultati modela Balanced Scorecard ostvareni u razvijenim gospodarstvima potaknuli su autora u istraživanju njegove eventualne moguće primjene na području financija. Model procjenjuje poslovanje polazeći od njegove četiri osnovne razine: financijske, marketinške, interne i organizacijske i služi kao osnova za implementaciju nove tržišno-orijentirane strategije poslovanja.

  18. Last call for Spitzer support of sample-return mission Hayabusa 2: measuring the thermal inertia of 1999 JU3

    Science.gov (United States)

    Mueller, Michael; Emery, Joshua; Rivkin, Andrew; Trilling, David; Hora, Joe; Delbo, Marco; Sugita, Seiji; Hasegawa, Sunao; Ishiguro, Masateru; Choi, Young-Jun; Mommert, Michael

    2012-12-01

    The JAXA mission Hayabusa 2, scheduled to launch in 2014/2015, will visit the low-albedo near-Earth asteroid 1999 JU3, and will return a regolith sample to Earth in 2020. An international observation campaign has amassed a large body of data toward the physical characterization of the target asteroid, informing the mission planning and maximizing the mission's scientific return. While the physical characterization of JU3 has advanced significantly in the past years, open questions remain that only Spitzer can answer: * Just what is the object's thermal inertia? Thermal inertia governs the surface temperature distribution, crucial knowledge for near-surface operations and sampling, and is an indicator for the presence or absence of regolith. Previous thermal observations led to inconclusive results. * Is there any surface variability in thermal inertia or albedo? There is tantalizing evidence for a variable 0.7-micron spectral feature, which may indicate further reaching surface heterogeneity. The only way to answer these questions before Hayabusa-2's arrival at its target is through Spitzer observations in 2013. Only Spitzer affords the required sensitivity and repeatability at thermal-infrared wavelengths. Additionally, due to JU3's peculiar orbit, 2013 is the last chance to obtain Spitzer observations through the end of 2016 (Horizons does not provide Spitzer-centric ephemerides beyond this date). JU3 is already too poorly placed for Earth-based observations to be obtained of sufficient quality to address these critical science questions. The 2013 apparition is uniquely favorable for thermal-inertia measurements from Spizter due to the wide range spanned in solar phase angle and sub-Spitzer latitude. We propose observations at 2 times 7 phase angles, with Spitzer-centric latitudes on both the Northern and Southern hemisphere. Additional thermal lightcurves will provide evidence for the presence of absence of thermal-inertia variegation over the surface.

  19. In vivo biodistribution for tumor targeting of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) nanoparticles.

    Science.gov (United States)

    Yan, Chengyun; Gu, Jiwei; Guo, Yuzhi; Chen, Dawei

    2010-06-01

    5-Fluorouracil-loaded N-succinyl-chitosan nanoparticles (5-FU-Suc-Chi/NP) were prepared by emulsification solvent diffusion. Biodistribution and tumor targeting were evaluated after i.v. administration of 5-Fu-Suc-Chi/NPs in Sarcoma 180-bearing mice. Also, pharmacokinetic profiles were evaluated after intravenous injection of 5-Fu-Suc-Chi/NP via the tail vein to rats. Our experimental results showed the 5-FU-Suc-Chi/NPs could be sustained at a high level in the blood for a very long time, implying its long systemic retention in the circulation. 5-FU-Suc-Chi/NPs were distributed mainly in tumors and liver, with small quantities being found in kidney and spleen. 5-FU-Suc-Chi/NPs accumulated only slightly in the heart and lung, and lowered the toxic effect of 5-FU in the heart and lung. Pharmacokinetic analysis in plasma showed the area under plasma concentration-time curve (AUC), elimination half-life (t(1/2)), and residence time (MRT) were increased 2.5-fold, 10.98-fold, and 10.8-fold for 5-FU-Suc-Chi/NP compared with that of free 5-FU, respectively. These results indicate that a long half-life in the circulation and tumor targeting of 5-FU-Suc-Chi/NPs are possible.

  20. 5-fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer.

    Science.gov (United States)

    Warusavitarne, Janindra; Ramanathan, Palaniappan; Kaufman, Anthony; Robinson, Bruce G; Schnitzler, Margaret

    2006-10-01

    Microsatellite instability is a recognised pathway of colorectal carcinogenesis responsible for about 15% of all sporadic colorectal cancers. Recent evidence has suggested that these tumours may not have the same response as microsatellite stable colon cancers to 5-fluorouracil (5FU)-based chemotherapy. The response to 5FU in four microsatellite unstable (MSI-H) cell lines was examined by cell viability assays and invasion assays. Flow cytometry was used to assess the effect of 5FU on MSI-H cell lines. In vivo response to 5FU was assessed by intraperitoneal injection of 5FU or control to 80 nude mice that had received intrasplenic injections of an MSI-H cell line KM12C prior to commencing treatment. There was inhibition of cell growth in MSI-H cell lines when treated with 5FU. There was no difference in invasiveness in the MSI-H cell lines when treated with 5FU. Primary tumours formed in 27 of the untreated and 25 of the 5FU treated mice (p=NS). There was a 36% reduction in splenic weight in those mice treated with 5FU (p5FU treatment of MSI-H tumours results in a reduction in growth but does not result in a reduction in invasion or metastasis.

  1. Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Be17402 / 5-FU cells

    Institute of Scientific and Technical Information of China (English)

    Yu-xiuLI; Zhi-binLIN; Huan-ranTAN

    2004-01-01

    AIM: To study the effect of wild type (wt) p53 gene transfection on drug resistant human hepatocellular carcinoma(HCC) cells induced by 5-Fluorouracil (5-FU). METHODS: The cytotoxicity of anticancer drugs on Be17402 and Be17402/5-FU cells was assessed using SRB assay, p53 expression was detected at its mRNA level by RT-PCR assay and at its protein level Western blot or immunocytochemistry assay in Be17402/5-FU cells transfected with either control vector or wt p53. AnnexinV-FITC/PI double labeled assay was performed to detect apoptosis. The chemosensitivity of Be17402/5-FU cells transfected with wt p53 was assessed using SRB assay. RESULTS: Be17402/5-FU cells exhibited cross-resistance to vincristine, doxorubicin, paclitaxel, and so on. wt p53 gene transfection upregulated the expression of p53 in Be17402/5-FU cells, wt p53 was able to greatly inhibit cell proliferation and significantly induce apoptosis in Be17402/5-FU cells. Moreover, wt p53 gene transfection increased the chemosensitivity of Be17402/5-FU cells to some anticancer drugs. CONCLUSION: These results indicated that the wt p53 gene transfection not only induced suppression of cell growth, but also increased the sensitivity of Be17402/5-FU cells to 5-FU, vincristine, and doxorubicin.

  2. Capacitación de líderes comunitarios como gestores sociales en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Carmen Álvarez

    2015-01-01

    Full Text Available El trabajo consiste en describir el desarrollo de un esquema de capacitación de líderes co - munitarios. El enfoque de la formación está dirigido a la gestión de proyectos de incidencia en las comunidades, basándose en diagnósticos participativos. El taller de formación de líderes comunitarios fue desarrollado por la Comisión Nacional para Prevenir y Erradicar la Violencia contra las Mujeres (Conavim en conjunto con la Universidad Autónoma de Ciudad Juárez y la Fundación del Empresariado Chihuahuense (Fechac y se diseñó tomando en consideración el ambiente de crisis social y de seguridad por la que atravesó Ciudad Juárez, así como en las necesidades de capacitación de promotores sociales expresadas en el programa “Todos somos Juárez”.

  3. Thermo-physical properties of 162173 (1999 JU3), a potential flyby and rendezvous target for interplanetary missions

    CERN Document Server

    Mueller, T G; Hasegawa, S; Abe, M; Kawakami, K; Kasuga, T; Kinoshita, D; Kuroda, D; Urakawa, S; Okumura, S; Sarugaku, Y; Miyasaka, S; Takagi, Y; Weissman, P R; Choi, Y -J; Larson, S; Yanagisawa, K; Nagayama, S

    2010-01-01

    Near-Earth asteroid 162173 (1999 JU3) is a potential flyby and rendezvous target for interplanetary missions because of its easy to reach orbit. The physical and thermal properties of the asteroid are relevant for establishing the scientific mission goals and also important in the context of near-Earth object studies in general. Our goal was to derive key physical parameters such as shape, spin-vector, size, geometric albedo, and surface properties of 162173 (1999 JU3). With three sets of published thermal observations (ground-based N-band, Akari IRC, Spitzer IRS), we applied a thermophysical model to derive the radiometric properties of the asteroid. The calculations were performed for the full range of possible shape and spin-vector solutions derived from the available sample of visual lightcurve observations. The near-Earth asteroid 162173 (1999 JU3) has an effective diameter of 0.87 +/- 0.03 km and a geometric albedo of 0.070 +/- 0.006. The chi2-test reveals a strong preference for a retrograde sense of r...

  4. Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer.

    Science.gov (United States)

    Rao, S; Cunningham, D; Hawkins, R E; Hill, M E; Smith, D; Daniel, F; Ross, P J; Oates, J; Norman, A R

    2005-05-09

    The purpose of this study was to determine whether epirubicin, cisplatin and infused 5FU (ECF) improves overall survival (OS) compared to 5FU, etoposide and leucovorin (FELV) in patients with previously untreated advanced biliary cancer in a prospective randomised study. Patients were randomly assigned to receive epirubicin, cisplatin and infused 5FU ECF or bolus 5FU etoposide and leucovorin (FELV). The primary end point was OS with secondary end points of objective response rate (ORR), failure-free survival (FFS), quality of life (QOL) and toxicity. In all, 54 patients were recruited with 27 randomly assigned to each arm. The median OS for ECF was 9.02 months (95% confidence interval (CI): 6.46-11.51) and FELV 12.03 months (95% CI: 9.3-14.7), P=0.2059. Objective response rates were similar for both arms: ECF 19.2% (95% CI: 6.55-39.3); FELV 15% (95% CI: 3.2-37.9), P=0.72. There was significantly increased grade 3/4 neutropenia with FELV vs ECF (53.8 vs 29.5%, respectively, P=0.020). Symptom resolution was impressive for both regimens. This is the largest reported randomised study to date in this setting. ECF did not improve OS compared to FELV, but was associated with less acute toxicity. These data suggest that chemotherapy can prolong OS and achieve good symptomatic relief in advanced biliary cancer.

  5. El impuesto predial en Ciudad Juárez desde una perspectiva de equidad

    Directory of Open Access Journals (Sweden)

    Sergio Peña-Medina

    2016-01-01

    Full Text Available El aspecto de equidad en el impuesto predial es un tema relevante que se aborda en este artículo. Ésta se diferencia entre vertical y horizontal; la primera se refiere a un enfoque progresivo en donde aquellas propiedades que valen más pagan una tasa superior a las de menor valor; la equidad horizontal apunta a un tema de valuación y, en ella, las propiedades comparables pagan la misma tasa. El artículo tiene como objetivo poner a prueba la hipótesis de regresividad del impuesto predial; se argumenta que ésta es inequitativa dado que en términos proporcionales las propiedades de menor valor pagan una tasa superior a las de mayor valor. Los resultados en esta investigación soportan la hipótesis de que existe un efecto de regresividad en el impuesto predial en Ciudad Juárez; consecuentemente es importante reflexionar sobre la estructura actual del sistema catastral.

  6. Daudzlietotāju tīmekļa RPG spēle

    OpenAIRE

    Dimitrijevs, Maksims

    2011-01-01

    „Daudzlietotāju tīmekļa RPG spēle” – cīņu spēles portāls, kas izstrādāts cilvēkiem, kam patīk spēlēt un sazināties ar citiem cilvēkiem, kādu laiku atrodoties mākslīgā pasaulē. Tā ir laba iespēja attīstīt savu stratēģisko domāšanu un fantāziju un atrast jaunus draugus. Moderatoriem ir iespēja kontrolēt kārtību portālā un veidot jaunus ieročus un bruņu. Savukārt administrators var pārvaldīt moderatorus un spēlētājus. Spēles uzbūve ļauj projektam augt, bet lietotāja saskarne paredzēta ērtai un i...

  7. Optical observations of NEA 162173 Ryugu (1999 JU3) during the 2016 apparition

    Science.gov (United States)

    Kim, Myung-Jin; Choi, Young-Jun; Moon, Hong-Kyu; Krugly, Yurij N.; Greenstreet, Sarah; Lister, Tim; Kaynar, Suleyman; Rumyantsev, Vasilij V.; Molotov, Igor E.; Donchev, Zahary

    2016-10-01

    Near-Earth asteroid 162173 Ryugu (1999 JU3) is the target of the JAXA's Hayabusa 2 spacecraft which is the first sample return mission to a C-type asteroid. The physical properties of Ryugu were investigated from vigorous ground-based observations conducted during the previous observational opportunities in the 2007 - 2008 and 2011 - 2012 apparitions. However, the pole orientation that is essential for the safety and fuel efficiency of landing and sampling on the asteroid was not precisely constrained due to large uncertainties in photometric data and small variations in the lightcurve amplitude, probably resulting from a spheroidal shape with the axial ratio a/b = 1.12. We carried out the network observations for Ryugu between European and American Continents, and also in Hawaii and Australia, during the end of July to the beginning of the August 2016 nearly simultaneously. We employed several 1-2 m class telescopes: RTT 1.5 m in Turkey, Terksol 2 m in Russia, Rozhen 2 m in Bulgaria, LCOGT 2 m Faulkes Telescopes in US and Australia, McDonald 2.1 m in USA, ZTSh 2.6 m in Crimea, Ukraine. Based on our dataset, we will present the rotational period and the amplitude using the dense lightcurve data.

  8. La cultura del feminicidio en Ciudad Juárez, 1993-1999

    Directory of Open Access Journals (Sweden)

    Julia Estela Fragoso Monárrez

    2000-01-01

    Full Text Available El proposito de esta investigación es analizar los asesinatos cometidos contra niñas y mujeres de Ciudad Juárez en los años de 1993 a 1999, a través de la categoría analítica del feminicidio. Diferenciar las distintas clases de feminicidios y delinear los perfiles sociodemográficos de vulnerabilidad de las niñas y las mujeres asesinadas. Finalmente clasificar la relación de parentesco entre la víctima y el victimario. Los datos se recolectaron de fuentes secundarias y oficiales para 162 víctimas. Los resultados arrojan un perfil preliminar sociodemográfico de las víctimas y confirman la existencia de varios tipos de feminicidios en algunos casos en relación a la ocupación de las víctimas. En cuanto a la noción de un asesino serial o una epidemia de machismo que repite patrones de exterminio, ambas categorías se encuentran presentes. Los resultados también confirman una relación de parentesco o desconocimiento entre las víctimas y el victimario

  9. La segregación socioespacial en Ciudad Juárez, Chihuahua, 1990-2010

    Directory of Open Access Journals (Sweden)

    Jairo A. López Navarrete

    2017-01-01

    Full Text Available El objetivo de este artículo es analizar la segregación socioespacial en el municipio de Ciudad Juárez, Chihuahua, para responder a la pregunta de investigación: ¿cuáles son las características principales de la distribución espacial de los estratos socioeconómicos, así como su evolución en el tiempo? El análisis factorial permite, mediante el método de componentes principales, combinar variables socioeconómicas y generar indicadores para saber si los habitantes de determinadas zonas urbanas comparten características similares, para analizar el grado de segregación espacial. La hipótesis de desigualdad no se pudo rechazar mediante la validez estadística de los índices de segregación socioespacial, excepto el del año 2000. Se concluye que el problema de la segregación es producto de la especulación del suelo de desarrolladores privados, y que también el Estado es un actor clave para generarla y revertirla.

  10. La vivienda precarista en Ciudad Juárez: urbanización de subsistencia

    Directory of Open Access Journals (Sweden)

    Guadalupe Valdivia

    2009-01-01

    Full Text Available En el presente ensayo se tiene como propósito destacar de qué manera los llamados grupos "marginados" de la sociedad buscan la satisfacción de un bien de consumo necesario como lo es la vivienda. Así también, se analiza el papel que juegan los grupos precaristas en una localidad como lo es Ciudad Juárez, la cual constituye en la actualidad la frontera de mayor importancia económica del país. La limitada participación del Estado en la oferta de vivienda ha llevado a estos grupos a satisfacer la demanda de este bien a través de la autoconstrucción, esto es, al margen de los mecanismos del mercado formal. Los grupos precaristas constituyen grandes contingentes de población en los cuales descansa la economía fronteriza. En esta localidad, este sector ha accedido al bien vivienda a través de la obtención del suelo urbano, en la mayoría de las veces por la vía de la invasión. Para lograr lo anterior, la ayuda mutua o solidaria, constituye la clave que les permite iniciar el largo camino, cuyo fin último es la obtención de una vivienda definitiva.

  11. El problema de la vivienda en Ciudad Juárez: los asentamientos humanos irregulares

    Directory of Open Access Journals (Sweden)

    Bertha Caraveo C.

    2009-01-01

    Full Text Available El presente artículo pretende plantear y explicar mediante un análisis exhaustivo el problema de la vivienda en Ciudad Juárez, ya que a raíz de este problema se originan diversos problemas sociales los cuales son explicados en la redacción del presente documento haciendo mención de los más destacados en la actualidad como lo son la incapacidad económica en la adquisición de las viviendas, debido a los bajos niveles de ingreso que perciben los individuos que residen en esta Ciudad, así como el incremento de la demanda por la migración de otras Ciudades hacia esta misma, ya que cada vez se genera una escasez de oferta, entrando en jugo la especulación en el mercado inmobiliario, promovido por las políticas económicas y de vivienda.

  12. Dominancia Cerebral en la Industria Maquiladora en Ciudad Juárez, Chihuahua, México

    Directory of Open Access Journals (Sweden)

    Alberto Castro

    2011-07-01

    Full Text Available El objetivo del estudio fue identificar modelos de pensamiento y habilidades en correspondencia al puesto y área laboral, mediante la evaluación del instrumento Herrmann de Dominancia Cerebral HBDI (Herrmann Brain Dominance Instrument, 1989, en una planta industrial de Ciudad Juárez, Chih. Participaron 176 gerentes y personal administrativo mexicanos. Se describen estadísticos de cuatro categorías de dominancia en tres áreas laborales. Se encontraron puntuaciones elevadas en las categorías lógico-controlador para todas las áreas laborales respecto a las habilidades interpersonales-holísticas, lo cual corresponde al manejo de dominancia cerebral del hemisferio cortical superior. Con una varianza total explicada del 76% en factorial confirmatorio y fiabilidad aceptable de la escala (α=.657, el instrumento fue identificado como versátil, económico y de fácil evaluación, al servir adecuadamente para selección, promoción, desarrollo organizacional y comprensión del clima laboral.

  13. Representaciones sociales de las mujeres operadoras en la industria maquiladora en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Erika Patricia Rojas González

    2013-01-01

    Full Text Available El tema medular del presente trabajo de investigación se centra en las variables que intervienen en la representación social (RS de las mujeres operadoras de producción en la industria maquiladora en ciudad Juárez con el fin de conocer de qué manera la (RS está influenciada por el estilo de vida y el entorno laboral y cómo les afecta a sus intereses particulares en los ámbitos laboral y personal. Los resultados obtenidos de la investigación inducen acciones que se traduzcan en práctica real de las políticas públicas “ya existentes” gestionando su impulso ante las instancias del gobierno con el fin de que los resultados expuestos en porcentajes, sean tomados para beneficio del estilo de vida y el entorno laboral de la mujer operadora de producción.

  14. Carbon monoxide exposure in households in Ciudad Juárez, México.

    Science.gov (United States)

    Montoya, Teresa; Gurian, Patrick L; Velázquez-Angulo, Gilberto; Corella-Barud, Verónica; Rojo, Analila; Graham, Jay P

    2008-03-01

    This study assessed exposure to carbon monoxide from gas and wood heater emissions in a sample of 64 households in peri-urban residential areas in Ciudad Juárez, Chihuahua, México. Indoor and outdoor carbon monoxide concentrations and temperatures were monitored for a continuous period of 1 week at 1 and 6-min intervals, respectively. The moving average carbon monoxide concentrations were compared to the World Health Organization (WHO) standards for carbon monoxide. Sixty-seven percent of households with gas heaters and 60% of households with wood heaters exceeded a health-based standard at some point during the monitoring. The difference between indoor and outdoor temperatures was modestly correlated with average carbon monoxide exposure (r=0.35, p-value <0.01). Heater type may be a stronger determinant of exposure, as households with a particular heater model (the El Sol FM-210) were significantly more likely to be among the more highly exposed households (odds ratio of 4.8, p-value of 0.02). A variety of health effects were pooled and found at elevated frequency in the households that exceeded the 8-h standard of 9ppm (odds ratio=5.1, p-value=0.031). These results highlight the need for further efforts to identify and mitigate potentially hazardous carbon monoxide exposures, particularly in moderate-income countries with cooler climates.

  15. Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?

    Science.gov (United States)

    Zhang, Jinqiang; Zhang, Lingli; Yan, Yumei; Li, Shaorong; Xie, Liang; Zhong, Wei; Lv, Jing; Zhang, Xiuhua; Bai, Yu; Cheng, Ziqiang

    2015-03-01

    Brain metastasis (BM) is increasingly diagnosed in Her2 positive breast cancer (BC) patients. Lack of effective treatment to breast cancer brain metastases (BCBMs) is probably due to inability of the current therapeutic agents to cross the blood-brain barrier. The central nervous system (CNS) response rate in BCBM patients was reported to improve from 2.6%-6% (lapatinib) to 20%-65% (lapatinib in combination with capecitabine). Lapatinib is a poor brain penetrant. In this study, we evaluated the CNS penetration of capecitabine and hoped to interpret the mechanism of the improved CNS response from the pharmacokinetic (PK) perspective. Capecitabine does not have antiproliferative activity and 5-fluorouracil (5-FU) is the active metabolite. Capecitabine was orally administered to mouse returning an unbound brain-to-blood ratio (Kp,uu,brain) at 0.13 and cerebrospinal fluid (CSF)-to-unbound blood ratio (Kp,uu,CSF) at 0.29 for 5-FU. Neither free brain nor CSF concentration of 5-FU can achieve antiproliferative concentration for 50% of maximal inhibition of cell proliferation of 4.57 µM. BCBM mice were treated with capecitabine monotherapy or in combination with lapatinib. The Kp,uu,brain value of 5-FU increased to 0.17 in the brain tumor in the presence of lapatinib, which is still far below unity. The calculated free concentration of 5-FU and lapatinib in the brain tumor did not reach the antiproliferative potency and neither treatment showed antitumor activity in the BCBM mice. The CNS penetration of 5-FU in human was predicted based on the penetration in preclinical brain tumor, CSF, and human PK and the predicted free CNS concentration was below the antiproliferative potency. These results suggest that CNS penetration of 5-FU and lapatinib are not desirable and development of a true CNS penetrable therapeutic agent will further improve the response rate for BCBM.

  16. In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.

    Science.gov (United States)

    Bezerra, Daniel P; de Castro, Fernanda O; Alves, Ana Paula N N; Pessoa, Cláudia; de Moraes, Manoel Odorico; Silveira, Edilberto R; Lima, Mary Anne S; Elmiro, Francisca Juliana M; de Alencar, Nylane M N; Mesquita, Rodney O; Lima, Michael W; Costa-Lotufo, Letícia V

    2008-03-01

    It has been reported that piplartine and piperine, alkaloid/amide compounds from Piper species, show antitumor activities. In the present paper, the effects of the combination of 5-fluorouracil (5-FU) with piplartine or piperine was determined using in vitro and in vivo experimental models. Hematological and biochemical analyses, as well as histopathological and morphological analyses of the tumor and the organs, including liver, spleen and kidney, were performed in order to evaluate the toxicological aspects associated with different treatments. The incubation of tumor cell lines with 5-FU in the presence of piplartine or piperine produced an increase in growth inhibition, as observed by lower IC50 values for 5-FU. These effects were also observed in vivo, where the combination with piplartine but not piperine with 5-FU led to a higher tumor growth inhibition. The results indicated that either piplartine- or 5-FU-treated animals showed a low inhibition rate when they were used individually at low doses of 28.67% and 47.71%, respectively, but when they were combined at the same dose, the inhibition rate increased significantly to 68.04%. The histopathological analysis showed that the livers and the kidneys of treated animals were only slightly and reversibly affected. Neither the enzymatic activity of transaminases nor the urea levels were significantly modified when compared with the control group. Hematological analysis showed leukopenia after 5-FU treatment, which was reversed by the combined use of piplartine and piperine. These findings indicate that piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5-FU.

  17. Randomised phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer

    NARCIS (Netherlands)

    Hospers, GAP; Schaapveld, M; Nortier, JWR; Wils, J; van Bochove, A; de Jong, RS; Creemers, GJ; Erjavec, Z; de Gooyer, DJ; Slee, PHTJ; Gerrits, CJH; Smit, J.M.; Mulder, NH

    2006-01-01

    Background: A phase III study was started to compare oxaliplatin/5FU/LV in the first-line with bolus FU/LV in metastatic colorectal cancer. Patients and methods: 302 patients were randomised and received bolus 5-FU 425 mg/m(2) day 1-5, FA 20 mg/m(2) day 1-5, q 4 wk or oxaliplatin 85 mg/m(2), 2 h-inf

  18. Effect of resveratrol and in combination with 5-FU on murine liver cancer

    Institute of Scientific and Technical Information of China (English)

    Sheng-Li Wu; Zhong-Jie Sun; Liang Yu; Ke-Wei Meng; Xing-Lei Qin; Cheng-En Pan

    2004-01-01

    AIM: To study the anti-tumor effect of resveratrol and in combination with 5-FU on murine liver cancer.METHODS: Transplantable murine hepatoma22 model was used to evaluate the anti-tumor activity of resveratrol (RES)alone or in combination with 5-FU in vivo. H22 cell cycles were analyzed with flow cytometry.RESULTS: Resveratrol could inhibit the growth of murine hepatoma22, after the mice bearing H22 tumor were treated with 10 mg/kg or 15 mg/kg resveratrol for ten days, and the inhibition rates were 36.3% (n = 10) and 49.3% (n = 9),respectively, which increased obviously compared with that in control group (85±22 vs 68±17, P<0.01). RES could induce the S phase arrest of H22 cells, and increase the persentage of cells in S phase from 59.1% (n = 9) to 73.5% (n = 9) in a dose-dependent manner (P<0.05). The enhanced inhibition of tumor growth by 5-FU was also observed in hepatoma22 bearing mice when 5-FU was administered in combination with 10 mg/kg resveratrol. The inhibition rates for 20 mg/kg or 10 mg/kg 5-FU in combination with 10 mg/kg resveratrol were 77.4% and 72.4%, respectively, compared with the group of 20 mg/kg or 10 mg/kg 5-FU alone, in which the inhibition rates were 53.4% and 43.8%, respectively (n = 8). There was a statistical significance between the combination group and 5-FU group.CONCLUSION: RES could induce the S phase arrest of H22cells and enhance the anti-tumor effect of 5-FU on murine hepatoma22 and antagonize its toxicity markedly. These results suggest that resveratrol, as a biochemical modulator to enhance the therapeutic effects of 5-FU, may be potentially useful in cancer chemotherapy.

  19. A molecular outflow driven by the brown dwarf binary FU Tau

    CERN Document Server

    Monin, J -L; Lefloch, B; Dougados, C; de Oliveira, C Alves

    2013-01-01

    We report the detection of a molecular outflow driven by the brown dwarf binary FU Tau. Using the IRAM 30 m telescope we observed the $^{12}$CO(2-1) (CO) emission in the vicinity of FU Tau and detected a bipolar outflow by examining the wings of the CO(2-1) line as we moved away from the source position. An integrated map of the wing emission between 3 kms$^{-1}$ and 5 kms$^{-1}$ reveals a blue-shifted lobe at a position of $\\sim$ 20 \\arcsec\\ from the FU Tau system and at a position angle of $\\sim$ 20$^{\\circ}$. The beam size of the observations is $11\\arcsec$\\ hence it is not possible to distinguish between the two components of the FU Tau binary. However as optical forbidden emission, a strong tracer of the shocks caused by outflow activity, has been detected in the spectrum of FU Tau A we assume this component to be the driving source of the molecular outflow. We estimate the mass and mass outflow rate of the outflow at 4 $\\times$ 10$^{-6}$ \\Msun\\ and 6 $\\times$ 10$^{-10}$ \\Msun/yr respectively. These resu...

  20. Targeting distribution of PEG-5-FU-MAMS in colorectal carcinoma tissue of nude mice%PEG-5-FU-MAMS靶向治疗裸鼠大肠癌的实验研究

    Institute of Scientific and Technical Information of China (English)

    房玉海; 张春林; 洪志飞

    2014-01-01

    目的 研究聚乙二醇(polyethylene glycol,PEG)修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-modified 5-FU magnetic albumin microsphere,PEG-5-FU-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-FU-MAMS)对大肠癌组织的被动靶向性,为实现大肠癌的主动靶向治疗,减少化疗药物的不良反应寻找新的途径.方法 30只人大肠癌裸鼠随机分为3组:(1)游离5-FU组;(2) 5-FU-MAMS组;(3) PEG-5-FU-MAMS组.每组10只,分别将3种不同的制剂(按5-FU 8mg/kg)经尾静脉给药,30分钟后,经眼眶采血,处死裸鼠,用HPLC法测定血清、肿瘤、肾脏、肝脏组织5-FU的浓度.结果 (1)PEG-5-FU-MAMS组、5-FU-MAMS组和游离5-FU组肿瘤组织中的药物浓度分别为(51.2±2.1) mg/L、(33.1 ±8.2)mg/L和(20.3±1.9) mg/L,PEG-5-FU-MAMS组肿瘤组织中药物浓度明显高于5-FU-MAMS和游离5-FU组(P<0.01);而在血清中药物浓度相反,PEG-5-FU-MAMS组[(1.7±0.5)mg/L]明显低于5-FU-MAMS[(6.8±0.2)mg/L]和游离5-FU组[(7.1±0.8)mg/L] (P <0.01);PEG-5-FU-MAMS组肝、肾脏中药物浓度[(22.7±2.4) mg/L和(21.1±2.3)mg/L]明显低于5-FU-MAMS[(44.3±6.7)mg/L和(38.2±4.9) mg/L]和游离5-FU组[(45.9 ±7.8)mg/L和(39.7±3.2)mg/L] (P <0.05).(2)PEG-5-FU-MAMS对裸鼠大肠癌的抑瘤率明显高于游离5-FU和5-FU-MAMS(45.3% vs 15.0%、30.1%,P<O.05).结论 PEG-5-FU-MAMS对大肠癌组织的靶向作用明显强于5-FU-MAMS和游离5-FU,但肝、肾脏的被动靶向作用明显减弱,有效地减轻药物对肝、肾脏的不良反应.PEG-5-FU-MAMS的抗结直肠癌作用明显强于游离5-FU和5-FU-MAMS.PEG-5-FU-MAMS有望成为肿瘤主动靶向治疗的有效药物.

  1. Minimal processing of juçara´s heart palm packed in brine acidifiedProcessamento mínimo de palmito juçara embalado em salmoura acidificada

    Directory of Open Access Journals (Sweden)

    Paula Fernanda Souza Aoki

    2012-04-01

    Full Text Available The juçara’s palm (Euterpe edulis, native to the Atlantic Forest is one of the palms most exploited for the removal of heart palm and the tree was removed in large areas. The aim of this study was to examine the feasibility of the methodology of "minimally processed" in juçara’s palm. The raw material was obtained by COOPERÁGUA, Sete Barras (SP through a Sustainable Management Plan culminating in a permit issued by IBAMA, Forestry Foundation and DPRN. The process began with the withdrawal of external sheaths and cut, with subsequent immersion in a solution of sodium metabisulphite (Na2S2O5– 200 ppm, sanitize with a chlorine solution and soak in brine acidified to wait until the filling. The cuttings were placed in polyethylene bags containing acidified solution at concentrations A 0.225%, B 0.375%, C 0.6%, D 0.825% determined by titration curve. The staining became clearer in treatments C and D, due to more acidity, resulting in higher inactivation of enzymes. Even with these positive results, were concluded that minimal processing of juçara is not effective due to the blackout, preventing its commercialization. To stop it requires the bleaching step, which does not characterize it as minimally processed.A palmeira juçara (Euterpe edulis, nativa da Mata Atlântica, é uma das mais exploradas para retirada do palmito; tratando-se de produto importante no bioma, a palmeira foi eliminada em vastas áreas. O objetivo deste trabalho foi analisar a viabilidade da metodologia “minimamente processados” para o palmito de juçara. A matéria-prima foi obtida através de Plano de Manejo Sustentável licenciado pelo IBAMA, Fundação Florestal e DPRN. O processamento iniciou-se com a retirada das bainhas externas e corte do palmito, com posteriores imersão em solução de metabissulfito de sódio (Na2S2O5 na concentração 200 ppm, higienização com solução clorada e imersão em salmoura acidificada de espera até o envase. Os toletes

  2. Overview of the Fusion Z-Pinch Experiment FuZE

    Science.gov (United States)

    Weber, T. R.; Shumlak, U.; Nelson, B. A.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Team

    2016-10-01

    Previously, the ZaP device, at the University of Washington, demonstrated sheared flow stabilized (SFS) Z-pinch plasmas. Instabilities that have historically plagued Z-pinch plasma confinement were mitigated using sheared flows generated from a coaxial plasma gun of the Marshall type. Based on these results, a new SFS Z-pinch experiment, the Fusion Z-pinch Experiment (FuZE), has been constructed. FuZE is designed to investigate the scaling of SFS Z-pinch plasmas towards fusion conditions. The experiment will be supported by high fidelity physics modeling using kinetic and fluid simulations. Initial plans are in place for a pulsed fusion reactor following the results of FuZE. Notably, the design relies on proven commercial technologies, including a modest discharge current (1.5 MA) and voltage (40 kV), and liquid metal electrodes. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

  3. Preparation and evaluation of chitosan based thermoreversible gels for intraperitoneal delivery of 5-fluorouracil (5-FU).

    Science.gov (United States)

    Depani, Bhavesh P; Naik, Anuja A; Nair, Hema A

    2013-12-01

    Sterile thermoreversibly gelling systems based on chitosan- glycerol phosphate were developed for intraperitoneal delivery of the antineoplastic agent 5-FU. The formulation was evaluated for gelling characteristics and in vitro drug release. Drug free gels were evaluated for in vitro cytotoxicity in L-929 mouse fibroblast cells. Drug loaded gels were subjected to acute toxicity studies in Swiss albino mice via intraperitoneal route and efficacy studies via intratumoral injections in subcutaneous colon carcinoma bearing BALB/c mice. The formulations gelled reversibly in 8 min at 37 °C and provided prolonged release of the drug. Drug free systems showed dose dependent cytotoxicity in fibroblast cells, while in vivo studies revealed a 2.8-fold increase in LD50 of 5-FU administered intraperitoneally as the developed system. Tumor volume measurements showed comparable efficacy of 5-FU administered as gel and commercial injection with a greatly improved safety profile of the former as adjudged from mortality and body weight measurements.

  4. Julgamento perceptivo-auditivo das oclusivas velares associadas à fissura labiopalatina por juízes com e sem experiência

    Directory of Open Access Journals (Sweden)

    Viviane Cristina de Castro Marino

    2015-12-01

    Full Text Available RESUMO: Objetivo: verificar: a o grau de concordância de juízes no julgamento perceptivo-auditivo da produção de oclusivas velares, antes e depois da fonoterapia; b a possível influência da composição fonética das amostras de fala nesta concordância e c se os julgamentos obtidos por juízes com experiência diferem daqueles obtidos por juízes sem experiência, nas condições investigadas. Métodos: 60 amostras de fala de uma criança com fissura labiopalatina (30 previamente e 30 posteriormente a fonoterapia e 30 amostras de fala de uma criança com fala típica (normal foram julgadas por um grupo de 9 juízes. Três fonoaudiólogos estabeleceram os julgamentos consensuais "padrão ouro" para o estudo. Seis outros juízes julgaram as amostras: três considerados com experiência (fonoaudiólogos e três sem experiência (alunos de graduação. As amostras de fala incluíram palavras constituídas pelas oclusivas velares /k/ e /g/ combinada com as vogais /a/, /i/ e /u/. Os juízes foram instruídos a julgar a presença, a ausência das oclusivas velares ou a presença de AC nestas amostras. Resultados: verificou-se diferenças no grau de concordância de juízes com experiência (Kappa moderada e sem experiência (Kappa baixo para os julgamentos realizados na condição pré-fonoterapia. O contexto fonético das amostras de fala influenciaram os julgamentos nas condições pré e pós-fonoterapia. Houve maior percentual de acerto para os juízes experientes condição pré-fonoterapia (p-valor <0,001. Conclusão: a experiência dos juízes e composição fonética das amostras de fala influenciam os julgamentos perceptivo-auditivos das AC.

  5. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer.

    Science.gov (United States)

    Ross, P; Nicolson, M; Cunningham, D; Valle, J; Seymour, M; Harper, P; Price, T; Anderson, H; Iveson, T; Hickish, T; Lofts, F; Norman, A

    2002-04-15

    We report the results of a prospectively randomized study that compared the combination of epirubicin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) (ECF) with the combination of mitomycin, cisplatin, and PVI 5-FU (MCF) in previously untreated patients with advanced esophagogastric cancer. Five hundred eighty patients with adenocarcinoma, squamous carcinoma, or undifferentiated carcinoma were randomized to receive either ECF (epirubicin 50 mg/m(2) every 3 weeks, cisplatin 60 mg/m(2) every 3 weeks and PVI 5-FU 200 mg/m(2)/d) or MCF (mitomycin 7 mg/m(2) every 6 weeks, cisplatin 60 mg/m(2) every 3 weeks, and PVI 5-FU 300 mg/m(2)/d) and analyzed for survival, response, toxicity, and quality of life (QOL). The overall response rate was 42.4% (95% confidence interval [CI], 37% to 48%) with ECF and 44.1% (95% CI, 38% to 50%) with MCF (P =.692). Toxicity was tolerable, and there were only two toxic deaths. ECF resulted in more grade 3/4 neutropenia and grade 2 alopecia, but MCF caused more thrombocytopenia and plantar-palmar erythema. Median survival was 9.4 months with ECF and 8.7 months with MCF (P =.315); at 1 year, 40.2% (95% CI, 34% to 46%) of ECF and 32.7% (95% CI, 27% to 38%) of MCF patients were alive. Median failure-free survival was 7 months with both regimens. Global QOL scores were better with ECF at 3 and 6 months. This study confirms response, survival, and QOL benefits of ECF observed in a previous randomized study. The equivalent efficacy of MCF was demonstrated, but QOL was superior with ECF. ECF remains one of the reference treatments for advanced esophagogastric cancer.

  6. Reply to communications by Fu et al. international journal of biometeorology

    Science.gov (United States)

    Wang, Huanjiong; Rutishauser, This; Tao, Zexing; Zhong, Shuying; Ge, Quansheng; Dai, Junhu

    2016-12-01

    Temperature sensitivity of plant phenology (ST) is a determining factor of as to what degree climate change impacts on plant species. Fu et al . (Int J Biometeorol 60:1611-1613, 2016) claimed that long long-term linear trends mask phenological shifts. However, the decreased and increased ST was both found in warming scenarios. The conceptual scheme telling the nonlinear relationship between spring temperature and leaf unfolding date proposed by Fu et al . (Int J Biometeorol 60:1611-1613, 2016) cannot be supported by observation data across Europe. Therefore, linking declined ST to climate warming is misleading, and future ST changes are more uncertain than they suggested.

  7. Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.

    Science.gov (United States)

    Brickell, K; Porter, D; Thompson, P

    2003-08-18

    Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receiving phenytoin will be prescribed treatment with fluoropyrimidines. We present two cases of clinical phenytoin toxicity occurring after starting treatment with 5-fluorouracil/folinic acid (5FU/FA) and a third who developed clinical phenytoin toxicity after starting capecitabine (an orally administered prodrug of fluorouracil).

  8. "Long term results of intraoperative 5-FU in Glaucoma filtering procedures "

    Directory of Open Access Journals (Sweden)

    "Hashemian MN

    2000-11-01

    Full Text Available This prospective study evaluated the long-term results of intraoperative 5-FU in glaucoma patients undergoing trabeculectomy. 14 patients categorized as high risk or medium risk underwent trabeculectomy with 5-FU and were followed for a mean period of 32 months. Patients were evaluated for visual acuity, cup-disc ratio and intraocular pressure (IOP; the number of medications was also taken into consideration. 78% (11 of patients achieved controlled IOP (< 21 mmHg with or without medication. There was statistically significant reduction of IOP and number of medications after the operation. There were no significant complications observed during the follow-up period.

  9. ShoFu Vintage比色板的数码摄影研究%The digital color-matching study of ShoFu Vintage shade

    Institute of Scientific and Technical Information of China (English)

    叶荣荣; 包向军; 王德芳

    2007-01-01

    目的 用数码摄影方法研究ShoFu Vintage(松风)比色板各比色片中1/3区域的亮度(L)值及R、G、B值的分布规律,以期提高临床修复体的比色准确率.方法 在5000K光源下用数码相机对ShoFu Vintage比色板的各比色片进行摄影,将拍摄结果输入计算机,运行Photoshop7.0软件,记录各比色片中1/3区域的亮度(L)和R、G、B值.结果 比色片的亮度(L)值及R、G、B值的分布与其A、B、C、D系列的分类有关.同系列比色片中随标号序数的增加,亮度(L)值及G、B值反而降低.R值分布表现为各系列中间序号的比色片较高.结论 数码摄影能够比较真实地再现ShoFu Vintage(松风)比色板的颜色,可作为临床修复体比色方法的补充.

  10. A juçara vai à escola: aprendizagem entre pessoas, coisas e instituições

    Directory of Open Access Journals (Sweden)

    Marcelo Gules Borges

    2015-12-01

    Full Text Available ResumoEste artigo é resultado de uma etnografia sobre materialidade, educação e aprendizagem realizada no contexto de uma rede local de educadoras ambientais atuantes em escolas públicas de ensino fundamental no litoral norte do Rio Grande do Sul, no Brasil. Tivemos por objetivo seguir as linhas que constituem o protagonismo da palmeira juçara, Euterpe edulis, espécie botânica conhecida popularmente como açaí da Mata Atlântica. Estivemos atentos aos seus usos nas práticas de alimentação e educação ambiental desenvolvidas pelas educadoras da Teia (Teia de Educação Ambiental da Mata Atlântica. Desde nossa perspectiva, a juçara é um outro não humano que participa de uma trama de relações sociais e materiais, entrelaçando pessoas, coisas e instituições e está no centro de um feixe de processos de aprendizagem individuais, sociais e ambientais. Dialogamos com uma noção de aprendizagem pensada a partir dos modos pelos quais experiências educativas são vividas nos termos de uma sintonia fina e dos laços de copertencimento com a dimensão não humana do ambiente, estabelecendo laços produtivos com outros humanos e não humanos. Nesse sentido, descrevemos a convivência entre as educadoras e a juçara como oportunidade para compreender formas de aprendizagem escolar e não escolar em uma comunidade rural no Rio Grande do Sul que, como qualquer outra, é constituída por um mundo mais que humano.

  11. Participación ciudadana en las colonias sin agua potable y alcantarillado de Ciudad Juárez, Chihuahua

    OpenAIRE

    Gustavo Córdova Bojórquez; Ma. de Lourdes Romo Aguilar

    2007-01-01

    En este artículo se presenta un análisis de la participación ciudadana en la gestión del agua en 14 colonias que carecen del servicio de agua potable y alcantarillado en Ciudad Juárez, Chihuahua. La metodología consistió en analizar y relacionar las influencias externas e internas de los ciudadanos resultando una participación ciudadana muy baja en la gestión del agua determinada en gran medida por el poco conocimiento sobre el tema, la poca confianza en las instituciones públicas, la mínima ...

  12. Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid

    NARCIS (Netherlands)

    Jansman, FGA; Coenen, JLLM; De Graaf, JC; Tobi, H; Sleijfer, DT; Brouwers, JRBJ

    2002-01-01

    Background: Dose adaptation based on pharmacokinetic parameters has been shown to decrease toxicity of some 5-fluorouracil(5-FU)-based continuous infusion regimens. Patients and Methods: In the present study the relationship between 5-FU pharmacokinetics in plasma and in saliva, and toxicity was inv

  13. Evaluation of 5-FU pharmacokinetics in cancer patients with DPD deficiency using a Bayesian limited sampling strategy

    NARCIS (Netherlands)

    Van Kuilenburg, A.; Hausler, P.; Schalhorn, A.; Tanck, M.; Proost, J.H.; Terborg, C.; Behnke, D.; Schwabe, W.; Jabschinsky, K.; Maring, J.G.

    2011-01-01

    Aims: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. The main purpose of this study was to develop a limited sampling strategy to evaluate the pharmacokinetics of 5FU and to detect dec

  14. Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet

    Directory of Open Access Journals (Sweden)

    Wei-Wen Kuo

    2011-01-01

    Full Text Available Apoptosis involves in the pathogenesis of various cardiac abnormalities. This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet. Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups. Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assays were performed to measure the effects of Li-Fu formula on left ventricle. Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group. Additionally, induced cardiac insulin like growth factor I receptor (IGFIR-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group. Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group. This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters. We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease.

  15. Latvijas Neredzīgo bibliotēkas pakalpojumu kvalitāte lietotāju vērtējumā

    OpenAIRE

    2013-01-01

    2011. gadā akreditācijas komisija konstatēja, ka Latvijas Neredzīgo bibliotēkas darbība neatbilst valsts nozīmes bibliotēkas statusa iegūšanai. Bibliotēkas veiktās lietotāju aptaujas rezultāti arī apliecina, ka lietotāji vēlētos, lai pakalpojumu sistēma tiktu pilnveidota. Tāpēc maģistra darbā tiek izzināts, vai ir atšķirības starp lietotāju vēlmēm un reāli saņemtajiem pakalpojumiem. Kā pētniecības metodes izmantota lietotāju aptauja (anketēšana), intervijas un situācijai adaptētais SERVQUAL m...

  16. Avaliação da Composição Centesimal, Mineral e Teor de Antocianinas da Polpa de Juçaí (Euterpe edulis Martius

    Directory of Open Access Journals (Sweden)

    Leilson de Oliveira Ribeiro

    2015-07-01

    Full Text Available A polpa de juçaí, fruto da palmeira juçara (Euterpe edulis Martius encontrada nas áreas da Mata Atlântica e a polpa de açaí, fruto da palmeira juçara (Euterpe oleracea Martius cultivado na Floresta Amazônica, foram caracterizadas obtendo assim sua composição centesimal, mineral e também seu teor de antocianinas. Com os resultados obtidos foi possível fazer um estudo comparativo da concentração de antocianinas das duas polpas congeladas e verificar a importância do consumo destes alimentos, classificados como funcionais, devido às propriedades antioxidantes de suas antocianinas no combate dos radicais livres no organismo humano.

  17. 城市应急重气扩散模型在JU2003扩散试验中的模拟验证%Simulation Verification of Urban Emergency Dense Gas Dispersion Model in JU2003 Dispersion Campaign Observation

    Institute of Scientific and Technical Information of China (English)

    黄江平; 王喜全; 王自发; 梁丹青

    2014-01-01

    发展了一个能够考虑昼夜大气稳定度差异的城市应急重气扩散模型——SLAB_URBAN模型,利用该模型对美国Oklahoma City Joint Urban 2003(JU2003)城市扩散试验进行了模拟,主要关注下风方向不同观测距离的Cmaxu/Q值,并将模型模拟出的C…u/Q值与JU2003试验观测的Cmaxu/Q值进行了对比验证.结果表明:SLAB_URBAN模型能够模拟出昼夜不同稳定度条件下城市重气扩散在下风方向浓度的分布状况;SLAB URBAN模型的统计误差分析显示其模拟结果与观测值较一致;此外,从应急反应和安全角度考虑,SLAB_URBAN模型也符合实际工作的需求.

  18. Civic Work, Civic Lessons: Intergenerational Reflections--An Interview with Thomas Ehrlich and Ernestine Fu

    Science.gov (United States)

    McTighe Musil, Caryn

    2014-01-01

    In a September 2013 interview, Thomas Ehrlich and Ernestine Fu--whose passion for public service is manifested in differing ways and from two dramatically different generational standpoints--discussed insights from their co-authored book, "Civic Work, Civic Lessons: Two Generations Reflect on Public Service (2013)." Septuagenarian Tom…

  19. 中国浮针疗法%CHINESE FU'S SUBCUTANEOUS NEEDLING

    Institute of Scientific and Technical Information of China (English)

    谭源生

    2007-01-01

    @@ Fu's Subcutaneous Needling is a kind of spreading needling in the subcutaneous shallow fascia around the limitative pain region[1,2]. Such therapy was invented in 1996. It is a kind of modern development on the basis of the traditional acupuncture, characterized as simple operation, safety, rapid therapeutic effect and broad indications.

  20. Unfälle mit Fußgängern

    Science.gov (United States)

    Burg, Heinz

    Auf einer gut ausgebauten Straße im innerörtlichen Bereich wurde eine Fußgängerin von einem Pkw erfasst. Die Fußgängerin kam für den Pkw von links. Nach Aussage einer Zeugin lief sie hinter einem Brückenpfeiler hervor auf die Fahrbahn, vermutlich um einen Bus zu erreichen. Die Kollisionsstelle war am Pkw vorne rechts, in der Frontscheibe rechts unten war eine Beschädigung, die wegen Haaranhaftung einem Kopfaufprall zugeordnet werden konnte. Vom Pkw waren Bremsspuren entstanden. Die Endlage der Fußgängerin und die Endlagen von Gegenständen konnten markiert und vermessen werden. Von der Polizei war ein Sachverständiger an die Unfallstelle gerufen worden. Er fand den Pkw in Endstellung und die auf der Fahrbahn liegenden Teile vor. Die Fußgängerin war bereits abtransportiert worden, der Pkw-Fahrer ebenfalls (Schock). Der Pkw-Fahrer hatte seinen Wagen abgesperrt.

  1. FU Ori-type outburst of 2MASS J06593158-0405277

    Science.gov (United States)

    Maehara, Hiroyuki; Kojima, Tadashi; Fujii, Mitsugu

    2014-11-01

    We report the discovery of an FU Ori-type outburst of 2MASS J06593158-0405277. The outburst was discovered by T. Kojima from the survey image obtained with a 85mm f/2.8 lens and Canon EOS 60D DSLR camera on 2014-11-03.821 UT at mag 11.0.

  2. FuGeF: A Resource Bound Secure Forwarding Protocol for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Idris Abubakar Umar

    2016-06-01

    Full Text Available Resource bound security solutions have facilitated the mitigation of spatio-temporal attacks by altering protocol semantics to provide minimal security while maintaining an acceptable level of performance. The Dynamic Window Secured Implicit Geographic Forwarding (DWSIGF routing protocol for Wireless Sensor Network (WSN has been proposed to achieve a minimal selection of malicious nodes by introducing a dynamic collection window period to the protocol’s semantics. However, its selection scheme suffers substantial packet losses due to the utilization of a single distance based parameter for node selection. In this paper, we propose a Fuzzy-based Geographic Forwarding protocol (FuGeF to minimize packet loss, while maintaining performance. The FuGeF utilizes a new form of dynamism and introduces three selection parameters: remaining energy, connectivity cost, and progressive distance, as well as a Fuzzy Logic System (FLS for node selection. These introduced mechanisms ensure the appropriate selection of a non-malicious node. Extensive simulation experiments have been conducted to evaluate the performance of the proposed FuGeF protocol as compared to DWSIGF variants. The simulation results show that the proposed FuGeF outperforms the two DWSIGF variants (DWSIGF-P and DWSIGF-R in terms of packet delivery.

  3. Nezakonit ribolov v morskih vodah na območju Evropske unije : diplomsko delo visokošolskega strokovnega študija Varnost in policijsko delo

    OpenAIRE

    Siničič, Aleš

    2014-01-01

    Diplomsko delo z naslovom Nezakonit ribolov v morskih vodah na območju Evropske unije predstavlja povezano področje (organizirane) ekološke kriminalitete in pojava nezakonitega ribolova. Glavni cilj diplomske naloge je identificirati in podrobno analizirati probleme nezakonitega ribolova kot oblike organizirane ekološke kriminalitete v morjih na območju Evropske unije z namenom iskanja predlogov rešitev. Ugotovitve, pridobljene s pomočjo analize pisnih virov, kažejo, da je obseg pojava nezako...

  4. Factores asociados con el uso inconsistente de condón en hombres que tienen sexo con hombres de ciudad juárez

    OpenAIRE

    2012-01-01

    Objetivo Analizar los factores asociados con el uso inconsistente de condón en hombres que tienen sexo con hombres (HSH) de Ciudad Juárez, Chihuahua. Material y métodos Se realizó un estudio observacional, transversal y analítico con una muestra por conveniencia (n=186) de HSH de Ciudad Juárez. Las variables independientes fueron: nivel socioeconómico, actitudes hacia del uso del condón, uso de drogas, consumo de alcohol, identidad por orientación sexual y la discrimina­ción por orientación s...

  5. Double Exposure and the Climate Gap: Changing demographics and extreme heat in Ciudad Juárez, Mexico.

    Science.gov (United States)

    Grineski, Sara E; Collins, Timothy W; McDonald, Yolanda J; Aldouri, Raed; Aboargob, Faraj; Eldeb, Abdelatif; Aguilar, María de Lourdes Romo; Velázquez-Angulo, Juárez Gilberto

    2015-02-01

    Scholars have recognized a climate gap, wherein poor communities face disproportionate impacts of climate change. Others have noted that climate change and economic globalization may mutually affect a region or social group, leading to double exposure. This paper investigates how current and changing patterns of neighborhood demographics are associated with extreme heat in the border city of Juárez, Mexico. Many Juárez neighborhoods are at-risk to triple exposures, in which residents suffer due to the conjoined effects of the global recession, drug war violence, and extreme heat. Due to impacts of the recession on maquiladora employment and the explosion of drug violence (since 2008), over 75% of neighborhoods experienced decreasing population density between 2000 and 2010 and the average neighborhood saw a 40% increase in the proportion of older adults. Neighborhoods with greater drops in population density and increases in the proportion of older residents over the decade are at significantly higher risk to extreme heat, as are neighborhoods with lower population density and lower levels of education. In this context, triple exposures are associated with a climate gap that most endangers lower socioeconomic status and increasingly older aged populations remaining in neighborhoods from which high proportions of residents have departed.

  6. Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5FU) mediated G1/S arrest and apoptosis in 5FU resistant carcinoma cell lines.

    Science.gov (United States)

    Didelot, C; Mirjolet, J-F; Barberi-Heyob, M; Ramacci, C; Teiten, M-H; Merlin, J L

    2003-07-01

    5-Fluorouracil (5FU) exposure can lead to both G1/S arrest and apoptosis induction which are dependent of P53 induction. The human papilloma virus oncoproteins (HPV), E6 and E7, inactivate respectively P53 and Rb. P53 degradation by E6 protein, leads to lack of G1/S arrest after genotoxic stress. Overexpression of E7 protein prevents P53-induced G1/S arrest following DNA damage. However, few studies have described 5FU effect and efficacy on cancer cell lines presenting HPV 18 positive status. KB cell line and KB3 subline presented wild-type P53 status and difference in 5FU sensitivity. During 5FU exposure, P53 gene and protein expression was increased in both cell lines. E6 and E7 mRNA and protein expression was decreased in KB and KB3. P53 and E6 protein expressions were inversely correlated. 5FU exposure, induced a G1/S arrest which can be maintained or intensified by P53 via P21 induction expression. 5FU exposure has led to apoptosis induction related to P53 induction. In the present study, 5FU exposure was shown to induce G1/S arrest and apoptosis by P53-dependent molecular pathway, in HPV 18 positive cells.

  7. 西汉梁国辞赋论略%Analysis on Ci Fu of Liang State in the Xi Han Dynasty

    Institute of Scientific and Technical Information of China (English)

    陈功文

    2015-01-01

    受梁孝王喜爱辞赋的影响,西汉梁园文人集团皆善辞赋,西汉梁国辞赋创作逐渐走向繁荣。贾谊的《旱云赋》、枚乘的《梁王菟园赋》及忘忧馆七赋是骚体赋向汉大赋过渡性质的作品。而枚乘与司马相如的大赋创作,不仅将梁园辞赋创作逐步推向了高峰,同时也将汉赋定型并推向了成熟,从而使汉赋成为一代之文学。%Influenced by the King of Liang's love for Ci Fu, Literati in the Xi Han Dynasty were all good at writing Ci Fu, which brought literary creation of Ci Fu to prosperity.Jia Yi's Han Yun Fu, Mei Cheng's Liang Wang Tu Yuan Fu and Lotus Hall Seven Fu were transitional works from Sao Ti Fu to Han Da Fu.Mei Cheng and Sima Xiangru's Fu creation, not only brought Ci Fu creation gradually to the peak, also promoted Han Fu to be mature. The result was that the Han Fu has become a generation of literature.

  8. A multicentre, randomised phase III trial comparing protracted venous infusion (PVI) 5-fluorouracil (5-FU) with PVI 5-FU plus mitomycin C in patients with inoperable oesophago-gastric cancer.

    Science.gov (United States)

    Tebbutt, N C; Norman, A; Cunningham, D; Iveson, T; Seymour, M; Hickish, T; Harper, P; Maisey, N; Mochlinski, K; Prior, Y; Hill, M

    2002-10-01

    This randomised study compared protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin C (MMC) in patients with advanced oesophago-gastric cancer. Two hundred and fifty-four patients with adenocarcinoma, squamous cell carcinoma or undifferentiated carcinoma involving the oesophagus, oesophago-gastric junction or the stomach were randomised. The major end points were tumour response, survival, toxicity and quality of life. The median age of patients treated was 72 years and the two arms were well-balanced for baseline demographic factors. The overall response rate was 16.1% [95% confidence interval (CI) 9.5% to 22.7%] in patients treated with PVI 5-FU alone compared with 19.1% (95% CI 12.0% to 26.0%) for those treated with PVI 5-FU plus MMC (P = 0.555). Median time to treatment failure was 3.9 months for PVI 5-FU and 3.8 months for PVI 5-FU plus MMC (P = 0.195). Median survival was 6.3 months for PVI 5-FU and 5.3 months for PVI 5-FU plus MMC (P = 1.0). Toxicity was mild for both treatments. Symptomatic benefit measured by improvement in pain control, weight loss, dysphagia and oesophageal reflux was observed in over 64% of patients in each arm. Quality of life scores were comparable in each arm. PVI 5-FU is a safe, effective form of palliation for patients with advanced oesophago-gastric cancer although the addition of MMC adds little extra benefit.

  9. [Establishment of a human laryngeal carcinoma Hep-2/5-Fu cell line and the screening of differentially expressed genes].

    Science.gov (United States)

    Chen, Jie; Wang, Jiadong

    2012-12-01

    To establish a Hep-2/5-Fu of human drug-resistant laryngeal carcinoma cell line, and to screen the possible drug resistance-associated genes. Hep-2/5-Fu of a human drug resistant laryngeal carcinoma cell line was induced by continuously exposing human laryngeal carcinoma cells to gradually increasing concentrations of 5-Fu. The growth law was observed and the growth curve was protracted. The drug resistance of Hep-2/5-Fu was measured by MTT assay and the drug resistant index RI was calculated. Genes expressed differentially between Hep-2/5-Fu and its parent cell line Hep-2 were screened using a gene chip, and several selected drug resistance associated genes were confirmed by reverse transcription-polymerase chain reaction (RT-PCR). Compared with its parental cells, the drug resistance cell line had slower growth rate and larger size. The Hep-2/5-Fu cell line showed cross drug resistance to 5-Fu, cisplatin and vincristine. There were 1210 differentially expressed genes possibly associated with drug resistance by the gene chip screening method. The possible drug resistance-related genes included Cyclin D, IGF-BP3, CASP9, and CDK4/6. The expression of Cyclin D in the Hep-2/5-Fu cell line was 6.5997 times of that in the parent cell line. RT-PCR results were consistent with the gene chip results. The altered biological properties of Hep-2/5-Fu may be related to its drug resistance phenotype. Several genes, such as Cyclin D, are possibly involved in the mechanism of drug resistance in this cell line.

  10. Review of Arciaga, Juárez y Mendoza (Coords. (2013. Introducción a la Psicología Social

    Directory of Open Access Journals (Sweden)

    Ali Lara

    2014-11-01

    Full Text Available Reseña del libro: Salvador Arciaga Bernal, Juana Juárez Romero y Jorge Mendoza Garcia  (coord. (2013. Introducción a la Psicología Social. México: UAM-MAPorrúa. ISBN 978-607-28-0109-7

  11. Faktoringa izmantošanas iespēju teorētiskā un praktiskā izpēte Latvijā

    OpenAIRE

    2009-01-01

    Bakalaura darba tēma ir „Faktoringa izmantošanas iespēju teorētiskā un praktiskā izpēte Latvijā”. Daudzi uzņēmumi saskaras ar informācijas trūkumu par faktoringa piedāvājumiem Latvijas tirgū, tāpēc autore šajā darbā ir izpētījusi un salīdzinājusi Latvijas galveno faktoringa devēju piedāvājumus. Darba mērķis ir noteikt uzņēmumam izdevīgāko faktoringa devēju, veicot Latvijas faktoringa tirgus analīzi. Darba rezultātā secināts, ka faktorings dod iespēju uzņēmumam paātrināt naudas līdzekļu ...

  12. N/om, Change, and Social Work: A Recursive Frame Analysis of the Transformative Rituals of the Ju/'hoan Bushmen

    Science.gov (United States)

    Keeney, Hillary; Keeney, Bradford

    2013-01-01

    The Ju/'hoan Bushman origin myth is depicted as a contextual frame for their healing and transformative ways. Using Recursive Frame Analysis, these performances are shown to be an enactment of the border crossing between First and Second Creation, that is, pre-linguistic and linguistic domains of experience. Here n/om, or the presumed creative…

  13. Conteúdo polifenólico e atividade antioxidante dos frutos da palmeira Juçara (Euterpe edulis Martius Polyphenolic content and antioxidant capacity of fruits of Juçara (Euterpe edulis Martius palm tree

    Directory of Open Access Journals (Sweden)

    C.P Lima

    2012-01-01

    Full Text Available O conteúdo polifenólico e a atividade antioxidante do extrato do fruto de Euterpe edulis Martius foram avaliados. Esta espécie é uma palmeira conhecida como Juçara, nativa da Mata Atlântica e utilizada para a extração de palmito. O processo de extração do palmito acarreta a morte da planta, uma vez que esta apresenta estipe único. A elevada demanda ocasionou a escassez deste recurso natural. Muitas espécies da Mata Atlântica podem ser utilizadas pelo manejo sustentável para a preservação e exploração econômica pelas comunidades locais. O fruto da palmeira Juçara pode ser uma das alternativas de manejo sustentável dos recursos naturais da Mata Atlântica. A capacidade antioxidante do fruto pode ser utilizada como justificativa para a aplicação como alimento nutricional. O conteúdo polifenólico do fruto foi determinado pelo método de Folin-Ciocalteau e os resultados obtidos foram: 10,31 ± 0,25%, 12,42 ± 0,89%, 12,75 ± 0,94%, para o extrato bruto, fração acetato de etila e fração remanescente, respectivamente. A atividade antioxidante foi determinada pelos métodos de redução do complexo fosfomolibdênico e DPPH. O extrato bruto e as frações acetato de etila e remanescente apresentaram atividade antioxidante, sendo que as duas últimas demonstraram maior atividade indicando que o conteúdo polifenólico pode ser responsável por esta atividade.The polyphenolic content and the antioxidant activity of Euterpe edulis Martius fruit extract were assessed. This species is a Palm tree known as Juçara, native to Atlantic Forest and used for palm heart extraction. The process of palm heart extraction leads to the death of the plant since the latter has one single stem. The high demand has resulted in the depletion of this natural resource. Many species from Atlantic Forest can be used by means of sustainable management for the preservation and economic exploration by local communities. The fruit of Juçara palm can be

  14. Quality of life in patients with advanced gastric cancer: a randomized trial comparing docetaxel, cisplatin, 5-FU (TCF with epirubicin, cisplatin, 5-FU (ECF

    Directory of Open Access Journals (Sweden)

    Montazeri Ali

    2006-12-01

    Full Text Available Abstract Background Health related quality of life (HRQOL is an important outcome after treatment for upper gastrointestinal carcinoma. This study aimed to compare HRQOL in patients with advanced gastric cancer (GC receiving either a standard or an experimental treatment. Methods Seventy-one patients have been treated in Cancer Institute (Tehran, Iran with docetaxel, cisplatin, 5 FU (TCF or epirubicin, cisplatin, 5-FU (ECF and were followed from Jan 2002 to Jan 2005. End points were response rate, HRQOL and survival. HRQOL was assessed using the EORCT QLQ-C30 at baseline and after the third cycle of chemotherapy. Results The baseline HRQOL scores were comparable between two groups. After treatment improvement was seen in a number of items and domains except for cognitive functioning, and diarrhoea. Pain decreased and physical functioning improved in both groups. However, only the TCF group showed statistically and clinically meaningful improvement in global QOL (P = 0.001. Surgical and pathologic response was better with TCF but there was no difference in survival rate between two groups. Conclusion Docetaxel based treatment (TCF showed better palliation and improvement of global QOL as compared with epirubicin based treatment (ECF. However, it seems that regardless of treatment offered, effective chemotherapy was the most important factor affecting QOL in these patients.

  15. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU.

    Science.gov (United States)

    Jiang, Yuqi; Li, Xiaoguang; Li, Xiaoyang; Hou, Jinning; Ding, Yongzheng; Zhang, Jian; Xu, Wenfang; Zhang, Yingjie

    2016-01-01

    Histone deacetylases (HDACs) inhibitors have multiple effects targeting the cancer cells and have become one of the promising cancer therapeutics with possibly broad applicability. Combination of HDAC inhibitors with the cytotoxic fluorouracil (5-FU) showed additive and synergistic effects both in vitro and in vivo. To explore the possibility in cancer therapy of a bivalent agent that combines two bioactive groups within a single molecular architecture, we designed and synthesized new dual-acting compounds by combining the bioactive fragment of MS-275, a clinical HDACs inhibitor, with cytotoxic agent 5-FU. The target compounds 9a and 9b showed comparable HDACs inhibition with MS-275 and moderate antiproliferative acitivities against six cancer cells lines.

  16. Evaluation of preoperative radiation therapy in combination with low dose carboplatin and 5FU

    Energy Technology Data Exchange (ETDEWEB)

    Yokomizo, Michinori; Tada, Hiroyuki; Ishikawa, Kazuo; Togawa, Kiyoshi [Akita Univ. (Japan). School of Medicine; Okamoto, Yoshitaka; Matsuzaki, Zensei

    1997-10-01

    A comparative study was performed to evaluate difference in the histological effects and side effects between a group of tongue cancer and hypopharyngeal cancer patients treated with 5FU (250 mg x 3 days/week) and 60 Gy radiation, and those treated with CBDCA (50-80 mg x 1 day/week) followed by 5FU (250 mg x 2 days/week) and 40 Gy radiation. In the tongue cancer patients, there was no significant change in histological effects according to Shimosato`s classification system. A decrease in leukocytes was found in the CBDCA group, which was not statistically significant. In cases with hypopharyngeal cancer, the number of leukocytes was significantly decreased in the CBDCA group. However the number of platelets and degree of stomatitis was not significantly altered. (author)

  17. COMBINATION OF 5-FU AND EPIRUBICIN IN THE TREATMENT OF ADVANCED GASTRIC CANCER

    Directory of Open Access Journals (Sweden)

    Ardeshir Ghavamzadeh

    1993-06-01

    Full Text Available This study was undertaken to assess the effectiveness of 5-FU plus epirubicin in the treatment of the advanced gastric cancer. For this purpose, 22 patients with no previous treatment were studied. All of the patients were unoperable or metastatic. Follow up checking continued for 24 months. Our selected therapeutic regimen consisted of a combination of 500 mg/m2 5-FU dialy for five days, and 75 mg/m2 epirubicin for one day. The response rate in this study was 47.4% and the mean survival rate was 9.7 months. By far, the most common complication was gastrointestinal disturbances and no carditoxicity was seen. Having presented the results of this study and comparing it with the other therapeutic regimens like FAM combination, this selected two drug combination seems to be a useful therapeutic protocol.

  18. The AKARI FU-HYU galaxy evolution program: first results from the GOODS-N field

    Science.gov (United States)

    Pearson, C. P.; Serjeant, S.; Negrello, M.; Takagi, T.; Jeong, W.-S.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M. S.

    2010-05-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands. We present the initial results for the FU-HYU survey in the GOODS-N field. We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produce a bimodal distribution where an excess at 11 microns preferentially selects moderate redshift star-forming galaxies. These powerful colour-colour diagnostics are further used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field showing that dusty starbursts can be selected of specific redshift ranges (z = 1.2-1.6) by mid-infrared drop-out techniques. The FU-HYU catalogue will be made publically available to the astronomical community.

  19. Posmodernisme Dalam Novel Generation X: Tales For Accelerated Culture Dan Bilangan Fu

    OpenAIRE

    Azmi, Nurul Nayla; Zein, Thirhaya

    2015-01-01

    This research is entitled Postmodernism in Novel Generation X: Tale of Accelerated Culture and Bilangan Fu which analyze postmodernism as the concept in both novel. This research is analyzed the postmodernism by theory of postmodernism by Baudrillard which divide it into two concept, they are simulacra and hyper reality. The method which is used in this research is descriptive qualitative. The data from this research is word, phrase,clause, nor sentence that found in the both object novel ...

  20. [A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy].

    Science.gov (United States)

    Iyama, Satoshi; Takahashi, Yasuo; Shintani, Naoaki; Fujikawa, Koshi; Ohkubo, Syunichi; Sato, Yasushi; Sato, Tsutomu; Sato, Yasuhiro; Ohnuma, Keisuke; Niitsu, Yoshiro

    2006-10-01

    We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic.

  1. Effect of 5-FU on modulation of disarrangement of immuneassociated cytokines in experimental acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Xiao-Li Chen; Sang-Zhu Ciren; Hui Zhang; Li-Geng Duan; Alexander J Wesley

    2009-01-01

    AIM: To investigate the effects of 5-Fluorouracil (5-FU)on modulation of pro-inflammatory and anti-inflammatory cytokines in acute pancreatitis and the mechanism of it in the treatment of acute pancreatitis.METHODS: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls ( n = 7); Group B, acute pancreatitis induced by ductal injection with 5% sodium cholate at a volume of 1.0 mL/kg without any other treatment; Group C, after the pancreatitis was induced as in Group B, the rats were injected intravenously with 5-FU 40 mg/kg. The animals in Groups B and C were killed at 2, 6 and 24 h after operation ( n = 7), and blood samples were taken for measurement of tumor necrosis factor-α (TNF-α),interleukin-1 (IL-1), interleukin-6 (IL-6) (by bioassay),and interleukin-10 (IL-10), transforming growth factor-β (TGF-β) (by ELISA). The wet weight of pancreatic tissue, serum amylase levels and white blood cells were also measured.RESULTS: Four rats in Group B and one in Group C died after pancreatitis was induced. Both pro-inflammatory cytokines (TNF-α, IL-1, IL-6) at the 2 and 6 h period and the anti-inflammatory cytokines (IL-10,TGF-β) at 24 h increased significantly ( P < 0.05) in rats of Group B. After treatment with 5-FU, TNF-α, IL-1, and IL-6 in serum of rats of Group C were inhibited at 2 and 6 h after operation ( P < 0.05), and IL-10, TGF-β were inhibited at 24 h compared to Group B ( P < 0.05). Obvious improvements in the severity of the acute pancreatitis,including the amylase levels, wet weight of pancreatic tissue and neutrophil counts, were also observed after treatment with 5-FU.

  2. AN ANALYSIS OF THE ENVIRONMENTS OF FU ORIONIS OBJECTS WITH HERSCHEL

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel [Department of Astronomy, The University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Kospal, Agnes [European Space Agency (ESA/ESTEC), Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Herczeg, Gregory [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quanz, Sascha P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Henning, Thomas; Bouwman, Jeroen [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Van Kempen, Tim A. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300-RA Leiden (Netherlands); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of); Dunham, Michael M. [Department of Astronomy, Yale University, New Haven, CT (United States); Meeus, Gwendolyn [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Campus Cantoblanco (Spain); Chen, Jo-hsin [Jet Propulsion Laboratory, Pasadena, CA (United States); Guedel, Manuel; Liebhart, Armin [Department of Astrophysics, University of Vienna (Austria); Skinner, Stephen L., E-mail: joel@astro.as.utexas.edu [Center for Astrophysics and Space Astronomy (CASA), University of Colorado, Boulder, CO 80309-0389 (United States)

    2013-08-01

    We present Herschel-HIFI, SPIRE, and PACS 50-670 {mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the 'FOOSH' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L{sub bol}, T{sub bol}, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of {sup 13}CO (J{sub up} of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 {yields} 22 and evidence for H{sub 2}O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for 'cool' CO components range from 20 to 81 K, for {approx} 10{sup 50} total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.

  3. Participación ciudadana en las colonias sin agua potable y alcantarillado de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Gustavo Córdova Bojórquez

    2007-01-01

    Full Text Available En este artículo se presenta un análisis de la participación ciudadana en la gestión del agua en 14 colonias que carecen del servicio de agua potable y alcantarillado en Ciudad Juárez, Chihuahua. La metodología consistió en analizar y relacionar las influencias externas e internas de los ciudadanos resultando una participación ciudadana muy baja en la gestión del agua determinada en gran medida por el poco conocimiento sobre el tema, la poca confianza en las instituciones públicas, la mínima disposición de participar en proyectos comunitarios y por la gran influencia que tiene el sistema político en la gestión del servicio.

  4. Determinantes de la proveeduría nacional a la industria maquiladora: el caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Raúl Ponce-Rodríguez

    2012-01-01

    Full Text Available Este artículo presenta un modelo teórico que explica la falta de integración vertical de la industria maquiladora con la industria local en Ciudad Juárez. En nuestro modelo teórico la demanda derivada de insumos depende de la tecnología de producción, el valor monetario del producto marginal, y los costos marginales de los factores de producción. El análisis teórico sugiere que si la productividad marginal cruzada entre los insumos importados y domésticos es negativa, las depreciaciones del tipo de cambio pueden inducir una menor integración vertical. Además, en este artículo presentamos evidencia de algunas de las propuestas de nuestro modelo teórico.

  5. Raising Children in a Violent Context: An intersectionality approach to understanding parents' experiences in Ciudad Juárez.

    Science.gov (United States)

    Grineski, Sara E; Hernández, Alma A; Ramos, Vicky

    2013-01-01

    Children and parents' daily lives are rarely highlighted in coverage of drug wars. Using 16 interviews with parents in the Mexican border city of Juárez in 2010, we examine how drug violence impacts families with a focus on intersections of gender and social class. Related to mobility (the first emergent theme), fathers had increased mobility as compared to mothers, which caused different stresses. Material hardships heightened mothers' isolation within the home, and mothers more often had to enforce children's mobility restrictions, which children resisted. Related to employment (the second emergent theme), fathers took on dangerous jobs to provide for the family while mothers had fewer options for informal employment due to violence. In sum, men and women faced different challenges, which were intensified due to class-based material disadvantages. Conformity with traditional gender expectations for behavior was common for men and women, illustrating the normalization of gender inequality within this context.

  6. The AKARI FU-HYU galaxy evolution program: First results from the GOODS-N field

    CERN Document Server

    Pearson, C P; Negrello, M; Takagi, T; Jeong, W -S; Matsuhara, H; Wada, T; Oyabu, S; Lee, H M; Im, M S

    2010-01-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands.We present the initial results for the FU-HYU survey in the GOODS-N field.We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produ...

  7. The Near-Contact Binary FU Ara: New Observations, a Photometric Study and Preliminary Elements

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new CCD (V) light curve is presented for'the semi-detached binary system FU Ara. The light curve, obtained in 2007, is the first one since the last 50 years. With our data we were able to determine six new times of minimum light and refined the period of the system to 0.8645049 days. A Wilson-Devinney analysis leads to a solution of a semi-detached configuration, composed of a main-sequence primary component of spectral type F5, fractionally smaller than its Roche lobe, and an evolved secondary component of spectral type K I which fills its Roche lobe, and which is overluminous and oversized as compared with the main-sequence. The two components of FU Ara differ considerably in effective temperature. It is classified as an FO Virginis type of near-contact binary system. Assuming a reasonable value for the mass of the primary component, an estimate of the absolute elements of FU Ara has been made, on the assumption that the primary has a mass corresponding to its spectral type according to Svechnikov & Taidakova.

  8. Development and characterization of 5-FU bearing ferritin appended solid lipid nanoparticles for tumour targeting.

    Science.gov (United States)

    Jain, Sanjay K; Chaurasiya, Akash; Gupta, Yashwant; Jain, Anekant; Dagur, Pradeep; Joshi, Beenu; Katoch, Vishwa M

    2008-08-01

    Ferritin coupled solid lipid nanoparticles were investigated for tumour targeting. Solid lipid nanoparticles were prepared using HSPC, cholesterol, DSPE and triolien. The SLNs without ferritin which has similar lipid composition were used for comparison. SLNs preparations were characterized for shape, size and percentage entrapment. The average size of SLNs was found to be in the range 110-152 nm and maximum drug entrapment was found to be 34.6-39.1%. In vitro drug release from the formulations is obeying fickian release kinetics. Cellular uptake and IC50 values of the formulation were determined in vitro in MDA-MB-468 breast cancer cells. In vitro cell binding of Fr-SLN exhibits 7.7-folds higher binding to MDA-MB-468 breast cancer cells in comparison to plain SLNs. Ex-vivo cytotoxicity assay on targeted nanoparticles gave IC50 of 1.28 microM and non-targeted nanoparticles gave IC50 of 3.56 microM. In therapeutic experiments, 5-FU, SLNs and Fr-SLNs were administered at the dose of 10 mg 5-FU/kg body weight to MDA-MB-468 tumour bearing Balb/c mice. Administration of Fr-SLNs formulation results in effective reduction in tumour growth as compared with free 5-FU and plain SLNs. The result demonstrates that this delivery system possessed an enhanced anti-tumour activity. The results warrant further evaluation of this delivery system.

  9. The Recovery Process of Murine Tracheal Epithelium Injured by 5-FU and Its Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Jingru ZHANG

    2009-02-01

    Full Text Available Background and objective Although there are increasing reports on localization of tracheal stem cells, the mechanism of proliferation and differentiation of tracheal stem cells remains unclear. Methods In this study, we developed an ex vivo model of murine tracheal epithelial injury and regeneration induced by 5-FU. The regenerationprocess of murine tracheal epithelium was observed and analyzed by morphological, immunofluorescence and microarray methods. Results After treatment with 5-FU, the differentiated mature cells were dead and desquamated. Only a few cells remained in G0 phase and located on the basement membrane. After being put back in normal culture media, the cells became flat, cubic and restored as pseudostratified epithelium at last. These G0 phase cells were ABCG2 positive. We detected the differences of stem cell genes between normal tracheal epithelial cells and regenerated epithelial cells at 24 h and 48 h after injured by 5-FU using stem cell differentiation gene microarray. At 24 h, 8 genes were up-regulated and 31 genes were down-regulated. At 48 h, 5 genes were up-regulated and 42 genes were down-regulated. Conclusion The differently expressed genes were mainly associated with cell cycle regulation, intercellular junction, FGF, BMP, Notch and Wnt signaling pathways, which suggested these alterations might be closely associated with the proliferation and differentiation of tracheal stem cells.

  10. Fu-Chan Wei—Surgeon, Innovator, and Leader of the Legendary Chang Gung Microsurgery Center

    Science.gov (United States)

    AL Deek, Nidal Farhan

    2016-01-01

    Fu-Chan Wei is a world-renowned plastic and reconstructive surgeon. He is clearly one of the most influential and innovative surgeons in the history of plastic surgery. The Taiwanese legend is the innovator of the osteoseptocutaneous fibula flap, which revolutionized the reconstruction of composite bone and soft tissue defects in the jaw and extremities. He has pioneered several perforator flaps, including the free style variety. He has taken toe-to-hand microsurgical transplantation to a whole new level. He is not only recognized for his surgical skills and clinical innovations, but also for his vision, leadership, and teaching. The establishment and development of the famous Microsurgery Center at Chang Gung Memorial Hospital is unparalleled anywhere. The international fellowship program in microsurgery there remains the envy of all microsurgical trainees. Dr. Wei and his colleagues have trained and influenced more than 1,500 surgeons from all over the world. The aim of this video article is to share what we learned by interviewing Fu-Chan Wei at Chang Gung. The story of Fu Chan Wei, his colleagues, and the development of the Microsurgery Center in Taiwan is worth knowing. PMID:27757352

  11. A randomised phase III trial of adjuvant radio-chemotherapy comparing Irinotecan, 5FU and Leucovorin to 5FU and Leucovorin in patients with rectal cancer: a Hellenic Cooperative Oncology Group Study.

    Science.gov (United States)

    Kalofonos, H P; Bamias, A; Koutras, A; Papakostas, P; Basdanis, G; Samantas, E; Karina, M; Misailidou, D; Pisanidis, N; Pentheroudakis, G; Economopoulos, T; Papadimitriou, C; Skarlos, D V; Pectasides, D; Stavropoulos, M; Bafaloukos, D; Kardamakis, D; Karanikiotis, C; Vourli, G; Fountzilas, G

    2008-08-01

    The primary objective was to compare the 3-year survival of rectal cancer patients randomised postoperatively to irinotecan (IRI), Leucovorin (LV) and bolus 5-fluorouracil (5FU) or LV-bolus 5FU with radiotherapy. Secondary objectives included disease-free survival, local relapse and toxicity. The study included 321 eligible patients. The treatment consisted of weekly administration of IRI 80 mg/m(2) intravenously (IV), LV 200 mg/m(2) and 5FU 450 mg/m(2) bolus (arm A) versus LV 200 mg/m(2) and 5FU 450 mg/m(2) IV bolus (arm B). One cycle included four infusions and treatment was continued for a total of six cycles. The first cycle was followed by pelvic irradiation plus 5FU. There were no differences between the arms in 3-year overall, disease-free and local relapse-free survival. Grades 3 and 4 toxicity was similar in both the arms with the exception of leucopaenia, neutropaenia and alopecia, which were higher in the IRI arm. IRI added to adjuvant radiochemotherapy with LV and bolus 5FU was not shown to improve survival, whereas the incidence of severe leucopaenia was significantly higher in the IRI arm.

  12. 奥运风云人物——伏明霞%Glorious People in Olympics History-Fu Mingxia

    Institute of Scientific and Technical Information of China (English)

    姜全红

    2006-01-01

    @@ Fu Mingxia completed a remarkable diving career that earned her the title Queen of Diving. Over a period of three Olympic Games (1992, 1996, 2000) she earned four gold and one silver medals, more than any other diver in history.

  13. RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53.

    Science.gov (United States)

    Russo, Patrizia; Malacarne, Davide; Falugi, Carla; Trombino, Sonya; O'Connor, Patrick M

    2002-07-20

    A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. We found that there was a slight tendency (not statistically significant) for the p53 inactivated cells to be less sensitive to 5-FU after 6 days continuous treatment. Simultaneous administration of RPR-115135 and 5-FU, at subtoxic concentrations, resulted in a synergistic enhancement of 5-FU cytotoxicity in the p53 wildtype cells (HCT-116, RKO, DLD-1, Colo-320, LoVo). In the p53 mutated cells (SW-620, HT-29, HCT-15, Colo-205, KM-12) the effect was very complicated. In HCT-15 the combination resulted in antagonism, in KM-12 in antagonism or in synergy (at different concentrations) and in SW-620, HT-29 and Colo-205 cells in synergy but only when 5-FU was administered at high concentrations. Growth inhibition could be accounted for on the basis of a specific cell cycle arrest phenotype (G2-M arrest), as assayed by flow cytometry, only in the p53 functioning cell lines. The combination RPR-115135 + 5-FU increases apoptotic events only in these cell lines. In the mutated cell lines no major alterations on cell cycle arrest phenotype and no induction of apoptosis was observed. Although RPR-115135 can potentiate the effect of 5-FU in cells in which p53 function is disrupted, these data suggest strongly that RPR-115135 significantly enhances the efficacy of 5-FU only when p53 is functioning.

  14. Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU).

    Science.gov (United States)

    Whitford, Eleanor J; Cummins, Adrian G; Butler, Ross N; Prisciandaro, Luca D; Fauser, Jane K; Yazbeck, Roger; Lawrence, Andrew; Cheah, Ker Y; Wright, Tessa H; Lymn, Kerry A; Howarth, Gordon S

    2009-03-15

    Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatment groups (n=8-10): Saline+Water; 5-FU+Skim Milk; 5-FU+Live TH-4; 5-FU+Supernatant TH-4; and 5-FU+Dead TH-4. 5-FU (150mg.kg(-1)) was administered by a single intraperitoneal injection on day 0; animals were killed on day 4. Treatments were administered daily from days -2 to 3 via oro-gastric gavage. Metabolic parameters were measured daily. Blood was obtained by cardiac puncture, and intestinal tissues removed for quantitative and qualitative histological assessment, including: villous height and area; crypt depth and area, mitotic count and crypt fission; biochemical determination of sucrase and myeloperoxidase (MPO) activity; and disease severity scoring. One-way ANOVA statistical analyses were conducted for the majority of outcome measures. Live TH-4 significantly reduced disease severity score by 13% (p5-FU+Skim milk controls. Live and supernatant TH-4 reduced crypt fission by 69% and 48% (p5-FU+Skim Milk controls. No significant differences (p> 0.05) in the occurrence of bacteraemia were evident across all groups. Live TH-4 partially normalised mitotic count and histological severity score in 5-FU treated rats. The inhibitory effect of live TH-4 and TH-4 supernatant on crypt fission suggests therapeutic utility in the prevention of disorders characterised by increased crypt fission, such as colorectal carcinoma.

  15. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    Directory of Open Access Journals (Sweden)

    Kurt Wachter

    2010-03-01

    Full Text Available Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  16. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    OpenAIRE

    Kurt Wachter

    2010-01-01

    Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  17. Fu Works of Sadness in Literary Selection%《文选》“哀伤”赋略论

    Institute of Scientific and Technical Information of China (English)

    冯莉

    2012-01-01

    The Fu in Literary Selection is divided into 15 categories according to their topics, in which the number of Fu works under the term of Fu of sadness is the most. The topic of sadness can be traced back to The Book of Songs. With full features in both contents and artistic expression, Fu of sadness is representative. Sadness Fu writings in different historical stages have different characters, not only displaying the development of Fu of sad- hess, but also highlighting the rationality and important value of Literary Selection in selecting articles.%《文选》将赋按照题材分为十五类目,其中"哀伤"一目选赋篇数最多;"哀伤"题材最早可上溯至先秦的《诗经》;"哀伤"赋选文无论在内容题材上还是艺术表现上都极富特色,具有代表性;不同历史阶段哀伤赋创作的不同特征,既呈现了哀伤赋的发展流变,也凸显了《文选》"哀伤"赋选文的合理性和重要价值。

  18. On Comical Literary Technique of Song Fu%论宋赋的滑稽艺术

    Institute of Scientific and Technical Information of China (English)

    刘培

    2015-01-01

    It is rather obvious that there is some inner impulse to entertain the author himself and other people in Cifu creation.Song Fu also attached much importance to comical description.The culture of the Song Dynasty paid close attention to deep cultivation, rational interest and noble moral.These three constitute the basic elements of the comical creation of Song Fu.Most scholar-bureaucrats in the Song Dynasty were both scholars and literati,and therefore their works always revealed their academic skills.It is highly desirable when we study Song Fu’s comical creation from the perspective of intertex-tuality.Scholar-bureaucrats in the Song Dynasty also adopted positive attitude rather than repulsion to mundane trait.Wandering between elegance and vulgarity,Song Fu made humorous feature of comical literary technique prominent with enormous contrasts between solemnity and frivolity,elegant and mediocrity.Song Fu could observe objects through feelings,interpret feelings through reason,merge feelings and reason together and balance them well,thus transcending the comicality of objects,arou-sing imagination and striking a chord in the hearts of the readers after a relaxation from reading Song Fu.Scholar-bureaucrats in Song Dynasty had critical spirits of real politik and conscientious moralities to the manners and morals of the times.Song Fu inherited the emotion of saving society from comical literary technique,and carried it forward.%辞赋创作自娱娱人的内在冲动相当明显,宋赋对滑稽描写相当重视。宋代文化重视学殖深淳、理趣盎然和道德情怀,这三者构成了宋赋滑稽艺术的基本要素。宋代文人大多兼具学者与作家身份,其诗文创作相当重视彰显学术,因而从互文性的角度来观照宋赋的滑稽艺术,是非常有必要、有意义的。对于滑稽的世俗特色,宋人在辞赋创作中以提升的态度来面对,而非拒斥。游走于雅与俗之间的宋赋,在庄严与轻

  19. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico

    Directory of Open Access Journals (Sweden)

    Bird Y

    2016-06-01

    Full Text Available Yelena Bird,1 Hugo Staines-Orozco2 1School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada; 2Institute of Biomedical Sciences, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Calle Estocolmo, Ciudad Juárez, Chihuahua, Mexico Background: Youth smoking trends among Latin American countries, including Mexico, are on the rise. Notably, although the high prevalence of smoking in teens has been well documented in the literature, few studies have evaluated the impact of smoking and secondhand smoke (SHS exposure on their respiratory system.  Objective: To investigate the effects of smoking and SHS exposure on the respiratory health and lung function among eighth-grade students in Juárez, Mexico. Methods: A cross-sectional study was undertaken on a sample of convenience. The study outcomes centered on evaluating 300 students’ lung function by spirometry (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC], and forced mid-expiratory flow rate [FEF25%–75%] and their respiratory health (smoking behavior and SHS exposure by their self-reported responses to a standardized respiratory questionnaire. The study outcomes were compared among three distinct groups: 1 nonsmokers/nonexposed to SHS; 2 nonsmokers/exposed to SHS; and 3 smokers. Results: The majority of the study participants were 14 years old (85%, females (54%, who attended eighth grade in a public school setting (56%. Approximately, half reported being of low socioeconomic status (49% and nonsmokers/exposed to SHS (49%. The lung function parameters of smokers were found to be lower (FEV1 =62.88±10.25; FEV1/FVC =83.50±14.15; and FEF25%–75% =66.35±12.55 than those recorded for the nonsmokers/exposed to SHS (FEV1 =69.41±11.35; FEV1/FVC =88.75±15.75; and FEF25%–75% =78.90±14.65 and significantly reduced when compared to the nonsmokers/nonexposed to SHS (FEV1 =79.14±13

  20. 5 Fu/CF联合 HCFU治疗晚期大肠癌%5-Fluorouracil,Leucovorin and Carmofur Combination in Treatment for Advanced Large intestinal Cancer

    Institute of Scientific and Technical Information of China (English)

    司海运; 岳晓婷

    2001-01-01

    [目的 ]观察 5 Fu/CF联合口服卡莫氟 (HCFU)与单用 5 Fu/CF治疗晚期大肠癌的近期疗效 . [方法 ]对 1998年 10月~ 2001年 4月收治的 36例大肠癌随机分为两组 , 治疗组 : 5 Fu/CF联合口服 HCFU; 对照组为 5 Fu/CF. [结果 ]治疗组总有效率 55.5% , 对照组总有效率 27.7% . [结论 ]5 Fu/CF联合口服 HCFU治疗晚期大肠癌较单用 5 Fu/CF方案化疗为好 .

  1. A qualidade de vida no trabalho de desembargadores e juízes da comarca de Belo Horizonte: estudo de casos

    Directory of Open Access Journals (Sweden)

    Lúcio Flávio Renault de Moraes

    2010-09-01

    Full Text Available

    Inicialmente investigou-se a qualidade de vida no trabalho dos desembargadores lotados no Tribunal de Justiça de Minas Gerais e dos juízes de primeira instância lotados no Fórum Lafayette em Belo Horizonte.

  2. Kung-Fu: synthesis of wheelchair sport and self-protection.

    Science.gov (United States)

    Madorsky, J G; Scanlon, J R; Smith, B

    1989-06-01

    As persons with disabilities enter the mainstream of society, and as the incidence of violent crime in society rises, disabled persons become victims of violent crime more frequently. It is vital for citizens with significant physical limitations to take precautionary steps for their own safety. Martial arts offer time-honored methods of self-protection for members of society who are physically disadvantaged. The case history of a young man with paraplegia is used to illustrate the potential of Kung-Fu as a sport and as a method of training for self-protection and survival.

  3. [Label-free monitoring 5-FU induced SW 620 cells apoptosis using FTIR microspectroscopy].

    Science.gov (United States)

    Liu, Dong; Sun, Xue-Jun; Zhang, Chao; He, Sai; Du, Jun-Kai; Huo, Xiong-Wei; Zheng, Jian-Bao; Zhang, Shi-Yun; Zhang, Yuan-Fuz; Xu, Yi-Zhuang; Wu, Jin-Guang

    2013-12-01

    The aim of the present study was to evaluate Fourier transform infrared spectroscopy (FTIR) monitoring of biochemical changes in apoptosis cells. Different concentrations of 5-fluorouracil (5-FU) treated colon cancer cell lines SW620 were used to determine the optimum concentration of 5-FU IC50 by means of MTT assay. Cell starvation and 5-Fu synergistic cell cycle arrest was in G1 and S phase. FTIR combined with flow cytometry was applied to analysis of SW 620 cells and SW620 cells treated with 5-FU for 12h, 24h (early apoptosis) and 48 h (late apoptosis) respectively. The peak position and the intensity of all bands were measured and comparison was made between the SW620 and apoptotic SW620 cells. Apoptosis cells have following characteristics compared with SW620 cells (1) The band at 1 740 cm-1 is an C=O stretching vibration. Changes in these bands can reflect lipid changes, and relative peak intensity ratio 11740/11460 significantly increased (p<0. 05), indicating that the relative contents of lipid in apoptosis cells increased. (2) The band at the 1 410 cm-1 peak represents that C-H stretching related was increased to amino acid residues and shifted to higher wave numbers compared to other groups. I1410o/I 460 at early and late death phase was significantly increased, which suggests that the relative contents of amino acid residues in apoptosis cells increased (p <0. 05). New vibrational bands at 1 120 cm-1 appeared at 24 h and increased at 48 h compared with other groups. The 1 120 cm-1 absorption band is mainly due to ser, serine and threonine C-O(H) stretching vibration, and I1120/I 1460 significantly increased (p<0. 05), indicating that the relative quantity of amino acid residues in apoptosis cells increased due to that DNA unwinds the double helix. (3) 1 240 cm-1 is mainly due to the asymmetric stretching modes of phosphodiester groups shifting to higher wave number, illustrating that nucleic acid conformation was changed in apoptosis cells. (4) The band

  4. Clinical outcomes of amniotic membrane loaded with5-FU PLGA nanoparticles in experimental trabeculectomy

    Institute of Scientific and Technical Information of China (English)

    Fang; Hu; Xiang-Yun; Zeng; Zhao-Lian; Xie; Lin-Lin; Liu; Liang; Huang

    2015-01-01

    AIM: To evaluate the effect of amniotic membrane loaded with 5-fluorouracil poly(lactic-co-glycolic acid)(PLGA) nanoparticles(5-FU-NPs) in the surgical outcomes of experimental trabeculectomy in rabbits.METHODS: Thirty-two New Zealand white rabbits were randomly categorized into four groups with 8 rabbits in each group. Group 1, the control group, performed traditional trabeculectomy without adjuvant treatment.While the experimental groups performed compound trabeculectomy with different implantations including amniotic membrane(group 2), 5-FU-NPs(group 3) and amniotic membrane loaded with 5-FU-NPs(group 4).Clinical evaluations including IOP measurement and filtration bleb analysis were performed in all groups postoperatively.RESULTS: There is no significant difference of mean IOP in all groups at first 7d after surgery. While at P14,mean IOPs of experimental group 2(9.8 ±2.1 mm Hg),groups 3(8.9 ±2.8 mm Hg) and group 4(7.6 ±2.3 mm Hg)were significantly reduced compared to control group(12.4 ±2.6 mm Hg; n =8, P <0.05). At P21, mean IOPs of groups 3(11.7±3.2 mm Hg) and group 4(9.9±1.6 mm Hg)were significantly decreased compare to control group(17.9±1.6 mm Hg) and group 2(16.6 ±2.8 mm Hg; n =8,P <0.05). At P28, mean IOPs of groups 3(13.8±3.3 mm Hg)and group 4(10.6 ±2.0 mm Hg) were also significantly reduced compare to control group(19.4±2.3 mm Hg) and group 2(18.5 ±2.4 mm Hg; n =8, P <0.05). Meanwhile mean IOP of group 4 is significantly decreased compared to group 3 at P28(n =8, P <0.05). Survival analysis of functional filtration blub in all groups revealed the longest survival time in group 4(24.9±5.1d) compared to that in group 3(20.6 ±4.3d), group 2(15.0 ±5.2d) and control group(10.1±5.7d).CONCLUSION: Amniotic membrane loaded with 5-FuNPs may function as an effective anti-scarring implant and provides improved long-term surgical outcomes for experimental trabeculectomy in rabbits.

  5. A Mobile Asteroid Surface Scout (MASCOT) for the Hayabusa 2 Mission to 1999 JU3: The Scientific Approach

    Science.gov (United States)

    Jaumann, Ralf; Bibring, Jean-Piere; Glassmeier, Karl-Heiz; Grott, Mathias; Ho, Tra-Mi; Ulamec, Stefan; Schmitz, Nicole; Auster, Ulrich; Biele, Jens; Kuninaka, Hitoshi; Okada, Tatsuaki; Yoshikawa, Makoto; Watanabe, Sei-ichiro; Fujimoto, Masaki; Spohn, Tilman; Koncz, Aalexander; Hercik, Davis; Michaelis, Harald

    2015-04-01

    MASCOT, a Mobile Asteroid Surface Scout, will support JAXA's Hayabusa 2 mission to investigate the C-type asteroid 1999 JU3 (1). The German Aer-ospace Center (DLR) develops MASCOT with contributions from CNES (France) (2,3,4). Main objective is to in-situ map the asteroid's geomorphol-ogy, the intimate mixture, texture and composition of the regolith (dust, soil and rocks), and the thermal, mechanical, and magnetic properties of the sur-face in order to provide ground truth for the orbiter remote measurements, support the selection of sampling sites, and provide context information for the returned samples. MASCOT comprises a payload of four scientific in-struments: camera, radiometer, magnetometer and hyperspectral microscope. C- and D-type asteroids hold clues to the origin of the solar system, the for-mation of planets, the origins of water and life on Earth, the protection of Earth from impacts, and resources for future human exploration. C- and D-types are dark and difficult to study from Earth, and have only been glimpsed by spacecraft. While results from recent missions (e.g., Hayabusa, NEAR (5, 6, 7)) have dramatically increased our understanding of asteroids, important questions remain open. For example, characterizing the properties of asteroid regolith in-situ would deliver important ground truth for further understanding telescopic and orbital observations and samples of such asteroids. MASCOT will descend and land on the asteroid and will change its own position up to two times by hopping. This enables measurements during descent, at the landing and hopping positions #1-3, and during hopping. Hayabusa 2 together with MASCOT launched December 3rd 2014, will arrive at 1999JU3 in 2018 and return samples back to Earth in 2020. References: (1) Vilas, F., Astronomical J. 1101-1105, 2008; (2) Ulamec, S., et al., Acta Astronautica, Vol. 93, pp. 460-466; (3) Jaumann et al., 45th LPSC, #1812, Houston; (4) Ho et al., 45th LPSC, #2535, Houston; (5) Spe-cial Issue

  6. Adolescents' smoking experiences, family structure, parental smoking and socio-economic status in Ciudad Juárez, Mexico.

    Science.gov (United States)

    Bird, Yelena; Staines-Orozco, Hugo; Moraros, John

    2016-02-20

    Cigarette smoking is the leading cause of preventable death worldwide. Tobacco use and secondhand-tobacco smoke (SHS) exposure are classified as a pediatric disease. In Mexico, the prevalence of smoking has decreased among adults but paradoxically increased among adolescents, particularly among young females. This study was designed to determine the association between adolescents' smoking experiences (smoking behaviors and second hand smoke [SHS] exposure), family structure, parental smoking and socio-economic status (SES) in Ciudad Juárez, Mexico. This is a cross-sectional, population-based study. Data was collected from sixth-grade students (N = 506) attending school in Ciudad Juárez, Mexico. Descriptive analyses were conducted. The relationship between key outcome variables (adolescents smoking and SHS exposure) and independent variables (family structure, parental smoking, and SES level) were examined. Adjusted odds ratios were calculated. Multiple logistic regression analysis was performed while controlling for possible confounders (i.e. gender and age). The overall prevalence of ever/lifetime smoking and SHS exposure at home was 29.6 and 41.1 %, respectively. Results of the logistic regression analysis show that being a member of a non-intact family [(OR = 2.20; 95 % CI = 1.21-3.90) and (OR = 2.45; 95 % CI = 1.19-4.10) respectively], having parents who smoke [(OR = 4.41; 95 % CI = 2.15-5.46) and (OR = 4.95; 95 % CI = 2.25-7.12) respectively], and living in low SES setting [(OR = 1.73; 95 % CI = 1.43-3.30) and (OR = 1.99; 95 % CI = 1.16-4.00) respectively] are significantly associated with ever smoking and SHS exposure at home among sixth grade students. The findings of our study show that tobacco use and SHS exposure are strongly associated with adolescents living in low SES, non-intact households that have parents that smoke. To be effective, tobacco strategies specifically tailored for this particularly vulnerable group of adolescents would require a

  7. Pircēju rīcības izpēte Latvijas nekustamo īpašumu tirgū.

    OpenAIRE

    Leonoviča, Indra

    2009-01-01

    Indra Leonoviča. Bakalaura darbs „Pircēju rīcības izpēte Latvijas nekustamo īpašumu tirgū”. Bakalaura darbā analizēta pircēju rīcība nekustamo īpašumu tirgū un pirkšanu ietekmējošie faktori ekonomiskās krīzes apstākļos. Pirmajā daļā pētīti pircēju rīcības patēriņa tirgū teorētiskie aspekti, otrajā daļā raksturots nekustamo īpašumu tirgus Latvijā, tirgus dinamika, veikta nozares vides analīze, izmantojot M.Portera modeli, PEST un SVID analīzes. Trešajā nodaļā apkopoti nekustamo īpašumu pirc...

  8. Patērētāju uzvedība Latvijas mobilo telekomunikāciju tirgū.

    OpenAIRE

    Lubgāne, Kristīne

    2008-01-01

    Bakalaura darba tēma ir Patērētāju uzvedība Latvijas mobilo telekomunikāciju tirgū. Bakalaura darba mērķis ir izpētīt patērētāju uzvedību, izvēloties mobilo sakaru operatoru. Izstrādātais bakalaura darbs sastāv no četrām nodaļām un divpadsmit apakšnodaļām. Darba apjoms ir 67 lapaspuses. Bakalaura darbā ir iekļauti 17 attēli un 4 tabulas. Pirmajā nodaļā tiks aprakstīts patērētāju uzvedības modelis un lēmums par pirkuma pieņemšanas procesu. Otrajā nodaļā tiks raksturota mobilo sakaru...

  9. Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol.

    Science.gov (United States)

    Luo, Yan; Ji, Xinmiao; Liu, Juanjuan; Li, Zhiyuan; Wang, Wenchao; Chen, Wei; Wang, Junfeng; Liu, Qingsong; Zhang, Xin

    2016-06-01

    Microtubules are the fundamental components in mitotic spindle, which plays essential roles in cell division. It was well known that purified microtubules could be affected by static magnetic fields (SMFs) in vitro because of the diamagnetic anisotropy of tubulin. However, whether these effects lead to cell division defects was unknown. Here we find that 1T SMFs induce abnormal mitotic spindles and increase mitotic index. Synchronization experiments show that SMFs delay cell exit from mitosis and cause mitotic arrest. These mimic the cellular effects of a microtubule-targeting drug Paclitaxel (Taxol), which is frequently used in combination with 5-Fluorouracil (5-FU) and Cisplatin in cancer treatment. Using four different human cancer cell lines, HeLa, HCT116, CNE-2Z and MCF7, we find that SMFs increase the antitumor efficacy of 5-FU or 5-FU/Taxol, but not Cisplatin, which indicates that the SMF-induced combinational effects with chemodrugs are drug-specific. Our study not only reveals the effect of SMFs on microtubules to cause abnormal mitotic spindles and delay cells exit from mitosis, but also implies the potential applications of SMFs in combination with chemotherapy drugs 5-FU or 5-FU/Taxol, but not with Cisplatin in cancer treatment.

  10. Impairment of energy metabolism in cardiomyocytes caused by 5-FU catabolites can be compensated by administration of amino acids.

    Science.gov (United States)

    Lischke, Julia; Lang, Christine; Sawodny, Oliver; Feuer, Ronny

    2015-01-01

    Identification of patients with increased risk of 5-fluorouracil (5-FU)-related toxicity is an important challenge for cancer treatment. Research often focus on dihydropyrimidine dehydrogenase (DPYD) deficiency in this context. However, patients with normal DPYD activity may also develop life-threatening 5-FU adverse effects. DPYD initiates the catabolic route of 5-FU generating metabolites such as fluoroacetate (FAC). The catabolite FAC is known to inhibit the TCA cycle enzyme aconitase, which is supposed to impair mitochondrial energy metabolism. Therefore, we aim for a systems understanding of the association of 5-FU-related cardiac side effects with aconitase inhibition caused by FAC. Using a mitochondrial model of cardiomyocytes we found strong depletion of ATP production and citrate accumulation as main effects of aconitase inhibition. Shadow price analysis revealed that the uptakes of valine, arginine, proline and glutamate are most effective in compensating the impairment of energy metabolism. Our findings suggest that 5-FU catabolism contributes to the occurrence of cardiac adverse effects and are the basis for further biomarker identifications and development of side effect treatment.

  11. Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro.

    Science.gov (United States)

    Shimoyama, Shouji; Mochizuki, Yoshino; Kusada, Osamu; Kaminishi, Michio

    2002-09-01

    We investigated supra-additive cytotoxic effects of 5-fluorouracil (5FU) on gastric and colon cancer cells with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in vitro. p53 wild- and mutant-type gastric and colon cancer cell lines were treated by 5FU alone, TRAIL alone, and a combination of 5FU and TRAIL, and cell viability after each treatment was determined by MTT assay. The p53 wild-type cells were more sensitive to 5FU alone or to TRAIL alone than p53 mutant-type cells. The cell growth inhibitory effects of the combined treatment were supra-additive and more significant in proportion to the increasing concentrations of TRAIL as compared with 5FU alone both in p53 wild- and mutant-type cells. Furthermore, TRAIL could cause a decrease in 5FU IC(50) to within the range of clinically relevant doses, particularly in p53 wild-type cells. This is the first demonstration of the supra-additive antitumor activity of 5FU with TRAIL on gastric cancer cells, giving evidence that TRAIL can reduce the requirement for 5FU that ultimately results in minimizing risks for systemic side effects while increasing the antitumor activity of 5FU, suggesting the clinical applicability of this combination for gastric and colon cancers.

  12. [Clinical effects of Fu Fang Ya Tong Ding on gingivitis and pericoronitis].

    Science.gov (United States)

    Wan, Hu-Chun; Zhang, Shuang; Wu, Ni-Ya; Kang, Dong; Hu, Li-Jie; Wang, Li-Zhi; Zhang, Ji-Ying; Xie, Ping

    2008-04-01

    To evaluate the clinical effects of Fu Fang Ya Tong Ding on treatment of gingivitis and pericoronitis. 120 clinical patients with gingivitis or pericoronitis were randomly divided into 3 groups (40 patients in each group). After routine rinse treatment for all patients, patients in the test group were treated with Fu Fang Ya Tong Ding, patients in the positive group were treated with iodine glycerol, while that time patients in the negative group received no treatment anymore. Ten minutes after treatment, visual analogue scale (VAS) was used to record the severity of pain for each patient. 3 days and 7 days later, pain and inflammation degree were also recorded by pain three-degree scoring method and index of gingivitis. The total treatment effects were evaluated under a comprehensive clinical treatment standard. 10 minutes after treatment, 40.0% of patients in the test group had almost no pain, while no obvious reduction of pain was found in the control group. 3 days, 7 days after the treatment, 92.5%, 95.0% of patients in the test group had no pain, and 55.0%, 90.0% of patients in the positive group had no pain. In the negative group, there were 47.5% of patients which pain was still remained in 7 days. 7 days after treatment, gingival index in the test group reduced by 25.0% and 42.8% compared with the positive and negative groups (Ppericoronitis through significantly reducing inflammation and pain.

  13. Evidence for an FU Orionis Outburst from a Classical T Tauri Star

    CERN Document Server

    Miller, Adam A; Covey, Kevin R; Poznanski, Dovi; Silverman, Jeffrey M; Kleiser, Io K W; Rojas-Ayala, Barbara; Muirhead, Philip S; Cenko, S Bradley; Bloom, Joshua S; Kasliwal, Mansi M; Filippenko, Alexei V; Law, Nicholas M; Ofek, Eran O; Dekany, Richard G; Rahmer, Gustavo; Hale, David; Smith, Roger; Quimby, Robert M; Nugent, Peter; Jacobsen, Janet; Zolkower, Jeff; Velur, Viswa; Walters, Richard; Henning, John; Bui, Khanh; McKenna, Dan; Kulkarni, Shrinivas R; Klein, Christopher R

    2010-01-01

    We present pre- and post-outburst observations of the new FU Orionis-like young stellar object Lk Halpha 188-G4 (also known as HBC 722 and PTF 10qpf). Prior to this outburst, Lk Halpha 188-G4 would have been classified as a classical T Tauri star on the basis of its optical emission-line spectrum superposed on a K8-type photosphere, and photometric variability. The mid-infrared spectral index of Lk Halpha 188-G4 indicates a Class II type object. Lk Halpha 188-G4 exhibited a steady rise by ~1 mag over ~11 months starting in Aug. 2009, before a subsequent more abrupt rise of >3 mag on a time scale of ~2 months. Observations taken during and after eruption exhibit all of the defining characteristics of FU Orionis variables: (i) Lk Halpha 188-G4 increased in brightness by >4 mag, (ii) a bright optical/near-infrared reflection nebula has now appeared (iii) optical spectra in the outburst phase are consistent with a G supergiant and dominated by absorption lines, the only exception being Halpha which is characteriz...

  14. SN 2011fu: A type IIb Supernova with a luminous double-peaked light curve

    CERN Document Server

    Morales-Garoffolo, A; Bersten, M; Jerkstrand, A; Taubenberger, S; Benetti, S; Cappellaro, E; Kotak, R; Pastorello, A; Bufano, F; Domínguez, R M; Ergon, M; Fraser, M; Gao, X; García, E; Howell, D A; Isern, J; Smartt, S J; Tomasella, L; Valenti, S

    2015-01-01

    We present optical and near infrared observations of the type IIb supernova (SN) 2011fu from a few days to $\\sim300$ d after explosion. The SN presents a double-peaked light curve (LC) similar to that of SN 1993J, although more luminous and with a longer cooling phase after the primary peak. The spectral evolution is also similar to SN 1993J's, with hydrogen dominating the spectra to $\\sim40$ d, then helium gaining strength, and nebular emission lines appearing from $\\sim60$ d post-explosion. The velocities derived from the P-Cygni absorptions are overall similar to those of other type IIb SNe. We have found a strong similarity between the oxygen and magnesium line profiles at late times, which suggests that these lines are forming at the same location within the ejecta. The hydrodynamical modelling of the pseudo-bolometric LC and the observed photospheric velocities suggest that SN 2011fu was the explosion of an extended star ($\\rm R\\sim450$ R$_\\odot$), in which 1.3 $\\times 10^{51}$ erg of kinetic energy wer...

  15. Laser sclerectomy and 5-FU controlled-drug-release biodegradable implant for glaucoma therapy

    Science.gov (United States)

    Villain, Franck L.; Parel, Jean-Marie A.; Kiss, Katalin; Parrish, Richard K.; Kuhne, Francois; Takesue, Yoshiko; Hostyn, Patrick

    1993-06-01

    Laser sclerectomy, a simple filtering procedure performed to alleviate high intraocular pressure in glaucoma patients, was taught to offer longer lasting effect and therefore improve the patient's outcome when compared with the standard trabeculectomy procedure. Recent clinical trials have shown that this was not the case and pharmacologic wound healing modulation is also required with this new procedure. Five-Fluorouracil (5-FU) is useful as an adjunct treatment for glaucoma filtering surgery. However, efficacy depends upon maintaining sustained drug levels, currently achieved by repeated daily injection of the drug for several weeks. To overcome this limitation, we designed a biodegradable implant for the sustained release of 5-FU. After laser sclerectomy, the implant is inserted through the same 1 mm wide conjunctival snip incision and positioned below the open channel. Implantation takes less than a minute. The implant releases the drug for over 15 days and totally biodegrades in less than 100 days. The combined laser surgery and implantation procedure show great potentials for the treatment of glaucoma.

  16. Concurrent chemoradiotherapy with daily low dose CDDP/5FU for locally unresectable head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kohno, Naoyuki; Kitahara, Satoshi; Tamura, Etsuyo; Tanabe, Tetsuya [Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine; Murata, Yasuhiro [National Defence Medical Coll., Tokorozawa, Saitama (Japan)

    2002-07-01

    To improve the local control rate and the prognosis of locally unresectable head and neck cancer patients, we studied the concurrent chemoradiotherapy. Between September 1996 and September 2000, thirty-eight patients with locally unresectable head and neck cancer were administered concurrent chemoradiotherapy consisting of low-dose and long-term treatment with cisplatin (CDDP) plus 5-fluorouracil (5FU), or (L-CF); the L-CF regimen consisted of CDDP, 3 mg/m{sup 2} on 5 days of the week and 5FU, 150 mg/m{sup 2} as a 24-hour infusion on 5 days of the week. Concurrently, conventional radiotherapy was given up to total dose of around 60 Gy. In the 36 patients evaluable for response, 19 complete and 10 partial responses were noted, with an overall response rate of 81%. Oral mucositis and myelosuppression were the major side effects and dose limiting toxicity. This study demonstrates increase in survival among the responders (complete+partial) in the concurrent chemoradiotherapy setting. We concluded that this treatment strategy was beneficial. Further studies for patients with locally unresectable head and neck cancer are warranted. (author)

  17. Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters

    Science.gov (United States)

    Cotomacio, Claudia Carrara; Campos, Luana; Nesadal de Souza, Douglas; Arana-Chavez, Victor Elias; Simões, Alyne

    2017-01-01

    Oral mucositis (OM) is a debilitating consequence of cancer treatment that could be treated with photobiomodulation therapy (PBMT); however, there is no consensus about its dosimetric parameters for OM healing. The aim of this study was to compare different PBMT protocols on OM treatment, through clinical and histological analysis. Thirty hamsters were used, in an induced model of OM by 5-fluorouracil (5-FU) and superficial scratching, in seven days of follow-up. The animals were divided into five groups: control (C), which received only anesthesia and chemotherapeutic vehicle; chemotherapy (Ch), which received anesthesia, 5-FU, and scratches; laser 1 (L1), the same as Ch group, PBMT 6 J/cm2 and 0.24 J (one point); laser 2 (L2), the same as Ch group, PBMT 25 J/cm2 and 1 J (one point); and laser 3 (L3), the same as Ch group, PBMT 4 points of 0.24 J and 6 J/cm2 each. The laser used has λ=660 nm, 0.04 cm2 of spot area, and 40 mW. The best PBMT protocol to maintain lowest OM levels compared to Ch group was L1, followed by L2 and L3. Our results suggest that the application mode of PBMT and the energy delivered per area could interfere with the OM healing.

  18. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Jensen, S; Vainer, B

    2009-01-01

    >T and 1298A>C polymorphisms were not associated with survival or relapse-free survival (P > 0.2). The 677 CC genotype was associated to toxicity (odds ratio = 1.83, P = 0.01). Conclusions: The MTHFR 677C>T and 1298A>C polymorphisms probably do not predict efficacy of adjuvant 5-FU treatment in colorectal......Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical....../leucovorin chemotherapy after intended curative resection between 1997 and 2003. Clinical data, including relapse rates, overall survival, and tumor stage, were collected. DNA was extracted from formalin-fixed tumor tissue and analyzed for the MTHFR 677C>T and 1298A>C SNPs with real-time PCR. Results: The MTHFR 677C...

  19. Inoperable esophageal carcinoma managed by combined chemotherapy (CBDCA, 5FU and VDS) and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Morishima, Yuichi; Tashiro, Tsuguhiko; Yamamori, Hideo [Chiba Univ. (Japan). School of Medicine] [and others

    1997-06-01

    Eleven inoperable patients with advanced esophageal carcinoma were treated with chemotherapy (carboplatin, 5-FU, vindesine) and concomitant radiotherapy. Two patients (T2) received this treatment due to their poor general condition and refusal of operation, and 9 patients for infiltration of tumor into the adjacent organs (T4). Administration of carboplatin (30 mg/body) and 5-FU (250 mg/body) together with radiotherapy (1.8 Gy/d) for 5 days a week was performed. This chemoradiation therapy was carried out for 5 consecutive weeks. In addition, vindesine (1-3 mg/body) was administered in the 1st and 4th week. After evaluation, endoscopic balloon dilatation was performed in 6 patients with stenosis of the esophagus. The general response rate was 80%. CR was noted in 2 patients of T2 but 1 patient of T4 developed severe leucopenia and immunosuppression, and died of septic MOF. All but the MOF case could take enough food orally following the endoscopic dilatation. The 1-year survival rate in the T4 group (45%) was significantly better than the non-treatment group (0%). In conclusion, this treatment is beneficial for patients with inoperable esophageal carcinoma to obtain a satisfactory QOL and survival rate. (author)

  20. Sensory descriptive quantitative analysis of unpasteurized and pasteurized juçara pulp (Euterpe edulis) during long-term storage.

    Science.gov (United States)

    da Silva, Paula Porrelli Moreira; Casemiro, Renata Cristina; Zillo, Rafaela Rebessi; de Camargo, Adriano Costa; Prospero, Evanilda Teresinha Perissinotto; Spoto, Marta Helena Fillet

    2014-07-01

    This study evaluated the effect of pasteurization followed by storage under different conditions on the sensory attributes of frozen juçara pulp using quantitative descriptive analysis (QDA). Pasteurization of packed frozen pulp was performed by its immersion in stainless steel tank containing water (80°C) for 5 min, followed by storage under refrigerated and frozen conditions. A trained sensory panel evaluated the samples (6°C) on day 1, 15, 30, 45, 60, 75, and 90. Sensory attributes were separated as follows: appearance (foamy, heterogeneous, purple, brown, oily, and creamy), aroma (sweet and fermented), taste (astringent, bitter, and sweet), and texture (oily and consistent), and compared to a reference material. In general, unpasteurized frozen pulp showed the highest score for foamy appearance, and pasteurized samples showed highest scores to creamy appearance. Pasteurized samples remained stable regarding brown color development while unpasteurized counterparts presented increase. Color is an important attribute related to the product identity. All attributes related to taste and texture remained constant during storage for all samples. Pasteurization followed by storage under frozen conditions has shown to be the best conservation method as samples submitted to such process received the best sensory evaluation, described as foamy, slightly heterogeneous, slightly bitter, and slightly astringent.

  1. Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project.

    Science.gov (United States)

    Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D'Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

    2016-06-02

    In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site.

  2. Optical Properties of (162173) 1999 JU3: In Preparation for the JAXA Hayabusa 2 Sample Return Mission

    CERN Document Server

    Ishiguro, Masateru; Hasegawa, Sunao; Kim, Myung-Jin; Choi, Young-Jun; Moskovitz, Nicholas; Abe, Shinsuke; Pan, Kang-Sian; Takahashi, Jun; Takagi, Yuhei; Arai, Akira; Tokimasa, Noritaka; Hsieh, Henry H; Thomas-Osip, Joanna E; Osip, David J; Abe, Masanao; Yoshikawa, Makoto; Urakawa, Seitaro; Hanayama, Hidekazu; Sekiguchi, Tomohiko; Wada, Kohei; Sumi, Takahiro; Tristram, Paul J; Furusawa, Kei; Abe, Fumio; Fukui, Akihiko; Nagayama, Takahiro; Warjurkar, Dhanraj S; Rau, Arne; Greiner, Jochen; Schady, Patricia; Knust, Fabian; Usui, Fumihiko; Mueller, Thomas G

    2014-01-01

    We investigated the magnitude-phase relation of (162173) 1999 JU3, a target asteroid for the JAXA Hayabusa 2 sample return mission. We initially employed the international Astronomical Union's H-G formalism but found that it fits less well using a single set of parameters. To improve the inadequate fit, we employed two photometric functions, the Shevchenko and Hapke functions. With the Shevchenko function, we found that the magnitude-phase relation exhibits linear behavior in a wide phase angle range (alpha = 5-75 deg) and shows weak nonlinear opposition brightening at alpha< 5 deg, providing a more reliable absolute magnitude of Hv = 19.25 +- 0.03. The phase slope (0.039 +- 0.001 mag/deg) and opposition effect amplitude (parameterized by the ratio of intensity at alpha=0.3 deg to that at alpha=5 deg, I(0.3)/I(5)=1.31+-0.05) are consistent with those of typical C-type asteroids. We also attempted to determine the parameters for the Hapke model, which are applicable for constructing the surface reflectance ...

  3. Study on the effects of sulfur fumigation on chemical constituents and antioxidant activity of Chrysanthemum morifolium cv. Hang-ju.

    Science.gov (United States)

    Wang, Shan; Hao, Li-Juan; Zhu, Jing-Jing; Zhang, Qi-Wei; Wang, Zhi-Min; Zhang, Xian; Song, Xiao-mei

    2014-04-15

    The traditional after-harvesting drying method of C. morifolium cv. Hang-ju (HJ) is sun drying, but recently sulfur fumigation is increasingly used as a cheap and convenient method. However, the effects of sulfur fumigation on chemical constituents and potential activities of HJ were unknown. A comprehensively comparison of the chemical profiles between non-fumigated HJ (NHJ) and sulfur-fumigated HJ (SHJ) was conducted by HPLC fingerprints analysis and the discrepant peaks were identified or tentatively assigned by HPLC-ESI/MS(n). Dramatic chemical changes were found that the contents of 4 flavonoid aglycones remarkably increased while those of 7 glycosides significantly reduced which suggested that sulfur-fumigation induced flavonoid glycosides transformed into aglycons by hydrolysis reaction. A significant loss of hydroxycinnamoylquinic acids showed the sulfur fumigation was a destructive effect on HJ. Principal component analysis (PCA) was employed to rapidly discriminate NHJ and SHJ samples. By ICP-OES analysis, it was found that the residue of sulfur of SHJ were three times higher than NHJ (p<0.05). The antioxidant activity of NHJ and SHJ were evaluated by DPPH and FRAP assay, and the results showed that NHJ had much stronger antioxidant activities than SCF (p<0.05). Combining the results of chemical analysis, residue of sulfur and pharmacological evaluation, it showed that the sulfur fumigation was a destructive effect on HJ.

  4. Segregación socioespacial y accesibilidad al empleo en Ciudad Juárez, Chihuahua (2000-2004

    Directory of Open Access Journals (Sweden)

    César M. Fuentes Flores

    2013-01-01

    Full Text Available En este artículo se analizó la relación espacial entre el índice de jerarquía socioespacial y el índice de accesibilidad a centros de empleo en Ciudad Juárez, Chihuahua, mediante el análisis exploratorio de datos espaciales, en dos etapas; en la primera se construyeron los índices mencionados y en la segunda se revisó su relación espacial, a través del mismo análisis, en específico de la autocorrela ción espacial y el análisis con indicadores locales de asociación espacial. Para la construcción de los índices se usó información de los censos de población y vivienda y el económico por ageb. El análisis espacial se llevó a cabo mediante el software Geoda. Los resultados probaron la relación espacial entre la segregación residencial y la accesibilidad a los centros de empleo, así como la identificación de agrupamientos homogéneos de agebs con un alto o bajo índice de jerarquía socioespacial y accesibiliadad al empleo, que permiten identificar clusters de exclusión social.

  5. [Geospatial distribution and detection of dengue virus in Aedes (Stegomyia) aegypti mosquitos in Ciudad Juárez, Chihuahua, Mexico].

    Science.gov (United States)

    de la Mora-Covarrubias, Antonio; Jiménez-Vega, Florinda; Treviño-Aguilar, Sandra Maritza

    2010-01-01

    To determine the distribution of Aedes aegypti in Ciudad Juárez, Mexico and evaluate it as a carrier of the dengue virus. Mosquitoes were collected using CDC minitraps. Nearest neighbor and K-function were used as geospatial tools. The chi-square test was utilized to evaluate the association between the presence of the vector and sociodemographic variables. Evidence of infection was detected by RT-PCR. A total of 122 female mosquitoes were captured. A tendency in the cluster distribution (R= -1.2995, p= 0.05) of the mosquito was shown up to 4000 m but none of the sociodemographic variables showed significant associations. Seven of the pools tested were positive for DEN-2, ten were positive for DEN- 3, and seven for both serotypes. This is the first report on the presence of Aedes aegypti mosquitoes infected with dengue in the region, which will enable the promotion of monitoring in order to reduce the probability of occurrence of the disease among the border population.

  6. Coverage of violence in risk areas: case of the Ciudad Juárez´Journalist Association

    Directory of Open Access Journals (Sweden)

    José Luis González-Esteban

    2016-11-01

    Full Text Available This research analyzes the situation of journalism in a high risk area, Ciudad Juarez, Mexico. The analysis is based on the knowledge and analysis of the training activity, violence and corruption denounced by Juarez Journalists Association, founded and run by women journalists. A meeting with journalists of the association and in-depth interviews are the main methodological tools to understand the meaning and value of this group of juarenses journalists. In the same way this article analyzes, through a quantitative methodology, the strategy of activism and the international projection of the association through their social networks. In addition, research is completed with a content analysis about the prevalence and significance of the ‘red note’ in El Diario de Juárez, the main newspaper in this border area, which even has a delegation in the US city of El Paso. Coverage of violence in high risk areas gives a special value to journalism in newspapers like the aforementioned and corporate work of this group of juarenses journalists.

  7. Bolívar, Juárez y Guevara: apuntes sobre socialización e identidad

    Directory of Open Access Journals (Sweden)

    Pedro António Da Silva-Abrantes

    2011-01-01

    Full Text Available A través de un análisis de las biografías de Bolívar, Juárez y Guevara, se discute la compleja relación entre socialización, identidad y cambio social, en los tiempos modernos. Tras un debate inicial sobre los usos y limitaciones del método biográfico, se busca comprender la vida de los tres personajes históricos, utilizando y buscando explorar algunas teorías sociológicas recientes. Se concluye que, en los tres casos, la integración desde temprana edad a distintos entornos sociales y, en particular, a procesos educativos múltiples resultantes de distintos movimientos político-pedagógicos, ocurrencias biográficas imprevistas e incluso a partir de cierta edad, de un trabajo consciente de los actores sobre sí mismos, permitió la formación de un habitus de fusión. Se argumenta que esta identidad peculiar personificó (y promovió la unificación de fuerzas sociales en conflicto.

  8. CDDP-5Fu-PYM化疗方案用于舌鳞癌的综合治疗

    Institute of Scientific and Technical Information of China (English)

    王贺伟; 任玉英; 苏平; 杜申钊; 许云

    2000-01-01

    目的:对于34例舌部鳞癌病人使用CDDP-5Fu-PYM化疗方案作为手术或放疗前的诱导化疗.方法:CDDP 80mg/m2,5Fu 3.0g,PYM 40mg在5天内按顺序给予.结果:7例原发灶消失,21例原发灶缩小50%以上,总有效率82.4%.结论:CD-DP-5Fu-PYM联合使用可以产生更加积极的抗肿瘤作用,取得满意的临床效果,为进一步治疗提供了良好的基础,有明显的优点和实用性.

  9. Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

    Science.gov (United States)

    Chen, Lijue; She, Xiaodong; Wang, Tao; He, Li; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

    2015-08-01

    Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The

  10. Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

  11. Etnoecologia e etnobotânica da palmeira juçara (Euterpe edulis Martius em comunidades quilombolas do Vale do Ribeira, São Paulo Ethnoecology and ethnobotany of the juçara palm (Euterpe edulis Martius in "quilombola" communities of the Ribeira River Valley, São Paulo

    Directory of Open Access Journals (Sweden)

    Renata Moreira Barroso

    2010-06-01

    Full Text Available As comunidades quilombolas são consideradas comunidades negras rurais formadas por descendentes de africanos escravizados. No Vale do Ribeira, uma das regiões mais pobres do estado de São Paulo, estas comunidades vivem da agricultura de subsistência e principalmente da coleta do palmito juçara para complemento da renda familiar. A palmeira juçara possui importante papel ecológico e econômico para a Floresta Atlântica e para as comunidades rurais locais. O objetivo geral deste trabalho foi investigar aspectos etnoecológicos e etnobotânicos da palmeira juçara (Euterpe edulis Martius em comunidades quilombolas do Vale do Ribeira, SP. A investigação se deu em sete comunidades quilombolas através da aplicação de 25 entrevistas semi-estruturadas e da realização de uma oficina de identificação dos animais consumidores de frutos da palmeira. Também foram realizadas coletas e identificação de visitantes florais. Os quilombolas entrevistados demonstraram um detalhado conhecimento ecológico local sobre a palmeira juçara, principalmente a relação da biodiversidade animal associada à espécie. Neste trabalho a etnoecologia e a etnobotânica mostram-se ferramentas importantes no levantamento participativo do conhecimento ecológico local do E. edulis que pode ser considerado no manejo e na conservação da espécie na Floresta Atlântica."Quilombola" communities are distributed all over Brazil. They are composed of the descendents of African slaves. In the Ribeira River Valley, one of the poorest regions in São Paulo state, they practice subsistence agriculture and extract plant resources from the environment, especially the juçara palm (Euterpe edulis Martius, a species that contributes to "quilombola" income. The juçara palm has special ecological and economic importance for "quilombolas". The main aim of this study was to investigate ethnobotanical and ethnoecological aspects of the juçara palm in "quilombola" communities

  12. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

    1997-11-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m{sup 2} as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m{sup 2}/d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [Deutsch] Der Standard in der Behandlung weit forgeschrittener, primaer inoperabler Kopf-Hals-Tumoren stellte die Cisplatinhaltige Chemotherapiekombination mit 5-FU dar mit simultan

  13. Comparison of force, power, and striking efficiency for a Kung Fu strike performed by novice and experienced practitioners: preliminary analysis.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F; Pacheco, Marcos Tadeu Tavares

    2008-02-01

    This paper presents a comparison of force, power, and efficiency values calculated from Kung Fu Yau-Man palm strikes, when performed by 7 experienced and 6 novice men. They performed 5 palm strikes to a freestanding basketball, recorded by high-speed camera at 1000 Hz. Nonparametric comparisons and correlations showed experienced practitioners presented larger values of mean muscle force, mean impact force, mean muscle power, mean impact power, and mean striking efficiency, as is noted in evidence obtained for other martial arts. Also, an interesting result was that for experienced Kung Fu practitioners, muscle power was linearly correlated with impact power (p = .98) but not for the novice practitioners (p = .46).

  14. Clinical research on disciplinarian and character of treatment of zang-fu in syndrome differentiation on insomnia

    Institute of Scientific and Technical Information of China (English)

    凌丽; 薛金伟; 东贵荣

    2005-01-01

    Objective To investigate the therapeutic effect of insomnia with zang-fu in syndrome differentiation. Methods Seventy patients with insomnia according to the diagnostic sequence were randomly divided into two groups, the treatment group and the control group. Two groups received the therapeutic methods of acupuncture in syndrome differentiation and general acupuncture separately. After two courses of treatment and one month's follow-up, therapeutic effect was evaluated through statistical analysis. Resulds The therapeutic effects of the treatment group and the control group have significant differences which have statistical significance. Conclusion Zang-fu in syndrome differentiation may enhance the clinical therapeutic effect of insomnia.

  15. Concomitant radiochemotherapy with 5-FU and cisplatin for invasive bladder cancer. Acute toxicity and first results

    Energy Technology Data Exchange (ETDEWEB)

    Birkenhake, S.; Leykamm, S.; Sauer, R. [Friedrich-Alexander Univ., Erlangen-Nuernberg (Germany). Dept. of Radiooncology; Martus, P. [Friedrich-Alexander Univ., Erlangen-Nuernberg (Germany). Dept. of Medical Statistics

    1999-03-01

    Purpose: To evaluate acute toxicity and efficacy of simultaneous radiochemotherapy for invasive urothelial cancer of the bladder. Patients and Methods: From September 1993 to July 1997, 61 patients with invasive bladder cancer were treated with a transurethral resection (TURB) followed by radiochemotherapy (RCT). Twenty-five received a combination of 5-FU and cisplatin. The prescribed doses were 600 mg/m{sup 2} 5-FU daily as continuous infusion over 5 days each in the 1st and 5th treatment week and 20 mg/m{sup 2} cisplatin daily at the same days as a short infusion. The pelvis was irradiated with 54 Gy, the bladder with 59.4 Gy and the paraortic nodes in 7 cases with 45 Gy, respectively. Six to 8 weeks after RCT a second TURB was performed for reasons of restaging. Results: Twenty out of 25 patients received at least 80% of the prescribed chemotherapy, in 13 cases the full dose could be given. Gastrointestinal toxicity of Grade I and II occurred in 10 cases, 1 patient developed severe diarrhea (Grade VI). After the 1st course of chemotherapy 7 patients had leuco- or thrombopenia of Grade III. One patient had a leucopenia of Grade IV. After the 2nd course 4 patients developed Grade III leuko- and thrombopenia, 1 of Grade IV. Two Grade II anemia were found. All more severe toxicities and necessary dose reductions were related to radiation of the paraaortic nodes. No life threatening infections, bleedings or cardiotoxicity was found. Restaging TURBs resulted in 22 complete remissions, 1 patient had a de-novo-carcinoma (Tis) at this time, 2 were non-responders (8%). After a median follow-up of 38 months 20 patients are alive (80%). Conclusions: 1. If irradiation of paraaortic nodes is necessary, 5-FU should not be applied, because the gastrointestinal toxicity is too extensive. In all other cases side effects are tolerable and can be managed by supportive care. 2. The first results are promising and should be evaluated in a prospective study. (orig.) [Deutsch

  16. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo.

    Science.gov (United States)

    Cheng, Mingrong; Gao, Xiaoyan; Wang, Yong; Chen, Houxiang; He, Bing; Li, Yingchun; Han, Jiang; Zhang, Zhiping

    2013-01-01

    Nanoparticle drug delivery systems using polymers hold promise for clinical applications. We synthesized dual-ligand modified chitosan (GCGA) nanoparticles using lactic acid, glycyrrhetinic acid, and chitosan to target the liver in our previous studies. We then synthesized the GCGA/5-FU nanoparticles by conjugating 5-fluorouracil (5-FU) onto the GCGA nanomaterial, which had a mean particle size of 239.9 nm, a polydispersity index of 0.040, a zeta potential of +21.2 mV, and a drug loading of 3.90%. GCGA/5-FU nanoparticles had good slow release properties, and the release process could be divided into five phases: small burst release, gentle release, second burst release, steady release, and slow release. Inhibitory effects of GCGA/5-FU on tumor cells targeted the liver, and were time and dose dependent. GCGA nanoparticles significantly prolonged the efficacy of 5-FU on tumor cells, and alleviated the resistance of tumor cells to 5-FU. GCGA/5-FU nanoparticles were mostly concentrated in the liver, indicating that the GCGA nanoparticles were liver targeting. GCGA/5-FU nanoparticles significantly suppressed tumor growth in orthotopic liver transplantation mouse model, and improved mouse survival.

  17. THE EFFECT OF LIVER MACROPHAGES ON INVITRO CYTOLYTIC ACTIVITY OF 5FU AND FUDR ON COLON-CARCINOMA CELLS - EVIDENCE OF MACROPHAGE ACTIVATION

    NARCIS (Netherlands)

    DAEMEN, T; REGTS, J; MORSELT, H; SCHERPHOF, GL

    1992-01-01

    While investigating the effects of 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FUdR) on the tumoricidal state of rat liver macrophages activated in vitro by means of liposome-encapsulated muramyl dipeptide (MDP), we observed that 5FU in combination with macrophages produced substantially high

  18. The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice.

    Science.gov (United States)

    Takahashi, Tetsuyuki; Ogawa, Hirohisa; Izumi, Keisuke; Uehara, Hisanori

    2011-07-01

    Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect of FuEP2/Ex2, a soluble decoy receptor for PGE(2) on growth of endometrial cancer cells. A stable transfectant expressing FuEP2/Ex2 was established from human endometrial cancer Ishikawa cells (Ish-FuEP2/Ex2). Ish-FuEP2/Ex2 cells expressed FuEP2/Ex2 mRNA and protein. Expression levels of E-prostanoid receptor 1 (EP1), EP2, EP3, EP4, and F-prostanoid receptor (FP) were almost the same in Ish-FuEP2/Ex2 and vector control cells. Growth rates of Ish-FuEP2/Ex2 under normal culture conditions were also similar to vector control cells, although PGE(2)-induced growth stimulation was completely inhibited in Ish-FuEP2/Ex2 or by Ish-FuEP2/Ex2 culture medium. Moreover, phosphorylation of extracellular signal-regulated kinase (ERK) and induction of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), cyclin D1, and c-fos mRNA by PGE(2) were not observed in Ish-FuEP2/Ex2 and Ish-FuEP2/Ex2 culture medium-treated vector control cells, although they were found when treated with prostaglandin F(2α). An orthotopic xenograft model in athymic nude mice revealed that Ish-FuEP2/Ex2-injected mice had significantly decreased mean tumor area. The proportion of Ki-67-positive cells in the tumor lesion was also significantly lower in Ish-FuEP2/Ex2-injected mice. These findings suggest that an EP-targeting strategy using FuEP2/Ex2 may be of use in the treatment of endometrial cancer.

  19. FU Orionis outbursts, preferential recondensation of water ice, and the formation of giant planets

    CERN Document Server

    Hubbard, Alexander

    2016-01-01

    Ices, including water ice, prefer to recondense onto pre-existing nuclei rather than spontaneously forming grains from a cloud of vapor. Interestingly, different potential recondensation nuclei have very different propensities to actually nucleate water ice at the temperatures associated with freeze-out in protoplanetary discs. Therefore, if a region in a disc is warmed and then recooled, water vapor should not be expected to refreeze evenly onto all available grains. Instead it will preferentially recondense onto the most favorable grains. When the recooling is slow enough, only the most favorable grains will nucleate ice, allowing them to recondense thick ice mantles. We quantify the conditions for preferential recondensation to rapidly create pebble-sized grains in protoplanetary discs and show that FU Orionis type outbursts have the appropriate cooling rates to drive pebble creation in a band about 5 astronomical units wide outside of the quiescent frost line from approximately Jupiter's orbit to Saturn's...

  20. 宋玉《讽赋》之讽%Critics on Feng Fu by Songyu

    Institute of Scientific and Technical Information of China (English)

    刘刚

    2012-01-01

    Feng Fu written by Songyu is a piece of critics on the statement of "Chu Xiangwang is lecherous". It generalizes the rules of female' s showing of love and basic principles of male' s self-control, which provides references for monarchs to identify woman' s charm. The nature of it is to prevent obscene.%宋玉的《讽赋》是针对“楚襄王好女色”的专题讽谏文章,全文借自我辩白,概括了女性示爱的典型规律和男性自律的基本规范,为君王认知女色和应对女色提供了经验性借鉴,其讽谏的实质是止欲与戒淫。

  1. From specific training to global shift of manual preference in Kung Fu experts.

    Science.gov (United States)

    Maeda, Rodrigo S; Souza, Rosana M; Teixeira, Luis A

    2014-02-01

    Manual preference and intermanual performance asymmetry have been approached from a multidimensional and dynamic perspective. A point of interest from that approach is the role of lateralized motor experiences on handedness. In this study, intermanual performance asymmetry in sport-specific movements and manual preference in daily living tasks were compared between Kung Fu athletes and novices. Analysis of movement time in the performance of interlaterally symmetric and asymmetric movement patterns showed smaller intermanual performance asymmetry in experts. Analysis of manual preference using the Edinburgh Handedness Inventory indicated that experts presented predominantly weak or moderate strength of right hand preference. Novices, conversely, were found to have predominantly strong right hand preference. These results suggest that extensive bimanual training by experts leads to a global shift of manual preference, affecting hand selection in distinct tasks.

  2. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda

    Directory of Open Access Journals (Sweden)

    Riyo Ramadhan

    2017-09-01

    Full Text Available Abstrak. Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll, yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Hal ini mengakibatkan para generasi muda memandang seni bela diri impor menjadi lebih superior ketimbang pencak silat. Jika hal ini terus berlangsung tanpa ada usaha untuk mengembangkan pencak silat melalui media modern, maka akan sangat sulit untuk mempertahankan dan mengembangkan tradisi ini di masa depan. Tujuan dari makalah ini ialah untuk membuktikan dan menggali potensi animasi sebagai media alternatif yang efektif untuk memvisualisasikan adegan dan cerita bertemakan pencak silat. Adapun studi kasus yang menjadi acuan dalam penelitian ialah film animasi “Kung Fu Panda”. Penelitian ini mengkaji studi kasus dengan menggunakan metode kualitatif deskriptif, lalu dianalisis dengan pendekatan analisis deskriptif untuk mengkaji dan mengidentifikasi pemasalahan dan solusi. Pembahasan dari makalah lebih ditekankan pada kekuatan penyampaikan cerita melalui gambar (visual storytelling yang efektif terkait dengan pencak silat. Hasil dari penelitian ialah cara penyampaian pesan yang efektif mengenai elemen dan esensi pencak silat sebagai bentuk translasinya kedalam film animasi. Pesan tersebut dapat disampaikan dengan menggunakan aspek narasi, gesture, dan simbol yang diakomodasi dengan aspek visual storytelling. Abstract. A tradition that has been part of Indonesian culture since ancient times, pencak silat was born as a form of self-defense and at the same time has grown into an art form that belongs to the cultural treasures of the Indonesian nation

  3. The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2014-01-01

    Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

  4. Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting

    Directory of Open Access Journals (Sweden)

    Peeyush Bhardwaj

    2014-01-01

    Full Text Available Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM. The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF at pH 1.2. The yield of microspheres was obtained up to 84.46±6.47%. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from 158.65±12.02 to 198.67±17.45 μm. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches.

  5. Mujeres indígenas, gobierno y comunidad: El caso de mujeres tarahumaras en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Martha Estela Pérez García

    2016-01-01

    Full Text Available La situación de las mujeres indígenas en Chihuahua se caracteriza por la marginación, pobreza y desigualdad. Por esta razón, algunos(as miembros de la etnia rarámuri obligados por las necesidades más elementales, emigran con sus familias a las principales ciudades de la entidad. En el caso específico de la comunidad indígena asentada en Ciudad Juárez, Chihuahua, encontramos que son mujeres quienes dirigen las tareas de gobierno, rol tradicionalmente asignados a los hombres. El objetivo de este artículo es realizar un acercamiento de la participación femenina en el gobierno de la colonia tarahumara, con el propósito de conocer cómo se genera esta participación, sus liderazgos y las formas de resolución de sus problemas al interior de la comunidad. Para este propósito se realizaron entrevista con representantes de la comunidad y sus dos gobernadoras, además de un grupo focal con la presidenta y un grupo de mujeres. Los resultados de esta investigación mostraron dos cuestiones significativas: la situación de extrema vulnerabilidad en que viven las indígenas en el entorno urbano y que el gobierno femenino usa estrategias apegadas al rol de género para mantener el orden, el liderazgo y mejorar la calidad de vida de su comunidad.

  6. Optical properties of (162173) 1999 JU3: in preparation for the JAXA Hayabusa 2 sample return mission

    Energy Technology Data Exchange (ETDEWEB)

    Ishiguro, Masateru [Department of Physics and Astronomy, Seoul National University, Gwanak, Seoul 151-742 (Korea, Republic of); Kuroda, Daisuke [Okayama Astrophysical Observatory, National Astronomical Observatory of Japan, Asakuchi, Okayama 719-0232 (Japan); Hasegawa, Sunao; Abe, Masanao; Yoshikawa, Makoto [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Sagamihara, Kanagawa 252-5210 (Japan); Kim, Myung-Jin [Department of Astronomy, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Choi, Young-Jun [Korea Astronomy and Space Science Institute, 776 Daedeokdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Moskovitz, Nicholas [Lowell Observatory, 1400 W. Mars Hill Road, Flagstaff, AZ 86001 (United States); Abe, Shinsuke [Department of Aerospace Engineering, Nihon University, 7-24-1 Narashinodai Funabashi, Chiba 274-8501 (Japan); Pan, Kang-Sian [Institute of Astronomy, National Central University, 300 Jhongda Road, Jhongli, Taoyuan 32001, Taiwan (China); Takahashi, Jun; Takagi, Yuhei; Arai, Akira [Nishi-Harima Astronomical Observatory, Center for Astronomy, University of Hyogo, Sayo, Hyogo 679-5313 (Japan); Tokimasa, Noritaka [Sayo Town Office, 2611-1 Sayo, Sayo-cho, Sayo, Hyogo 679-5380 (Japan); Hsieh, Henry H. [Academia Sinica Institute of Astronomy and Astrophysics, Roosevelt Road, Taipei 10617, Taiwan (China); Thomas-Osip, Joanna E.; Osip, David J. [The Observatories of the Carnegie Institute of Washington, Las Campanas Observatory, Colina El Pino, Casilla 601, La Serena (Chile); Urakawa, Seitaro [Bisei Spaceguard Center, Japan Spaceguard Association, 1716-3 Okura, Bisei-cho, Ibara, Okayama 714-1411 (Japan); Hanayama, Hidekazu [Ishigakijima Astronomical Observatory, National Astronomical Observatory of Japan, 1024-1 Arakawa, Ishigaki, Okinawa 907-0024 (Japan); Sekiguchi, Tomohiko [Department of Teacher Training, Hokkaido University of Education, 9 Hokumon, Asahikawa 070-8621 (Japan); and others

    2014-09-01

    We investigated the magnitude-phase relation of (162173) 1999 JU3, a target asteroid for the JAXA Hayabusa 2 sample return mission. We initially employed the International Astronomical Union's H-G formalism but found that it fits less well using a single set of parameters. To improve the inadequate fit, we employed two photometric functions: the Shevchenko and Hapke functions. With the Shevchenko function, we found that the magnitude-phase relation exhibits linear behavior in a wide phase angle range (α = 5°-75°) and shows weak nonlinear opposition brightening at α < 5°, providing a more reliable absolute magnitude of H {sub V} = 19.25 ± 0.03. The phase slope (0.039 ± 0.001 mag deg{sup –1}) and opposition effect amplitude (parameterized by the ratio of intensity at α = 0.°3 to that at α = 5°, I(0.°3)/I(5°) = 1.31 ± 0.05) are consistent with those of typical C-type asteroids. We also attempted to determine the parameters for the Hapke model, which are applicable for constructing the surface reflectance map with the Hayabusa 2 onboard cameras. Although we could not constrain the full set of Hapke parameters, we obtained possible values, w = 0.041, g = –0.38, B {sub 0} = 1.43, and h = 0.050, assuming a surface roughness parameter θ-bar = 20°. By combining our photometric study with a thermal model of the asteroid, we obtained a geometric albedo of p {sub v} = 0.047 ± 0.003, phase integral q = 0.32 ± 0.03, and Bond albedo A {sub B} = 0.014 ± 0.002, which are commensurate with the values for common C-type asteroids.

  7. La estructura espacial urbana y accesibilidad diferenciada a centros de empleo en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    César M. Fuentes Flores

    2009-01-01

    Full Text Available Existen disparidades intraurbanas en los tiempos de traslado del viaje al trabajo en transporte público y privado, producto de una accesibilidad diferenciada a los centros de empleo en Ciudad Juárez, Chihuahua; el objetivo del artículo es explicarlas. La metodología empleada es el análisis espacial, además se elaboraron cuatro modelos de regresión simple estimados mediante la técnica de mínimos cuadrados ordinarios (MCO. Las variables se construyeron con información de la Encuesta de origen-destino de 1997, el XII Censo general de población y vivienda de 2000 y el XIII Censo económico de 1999, a nivel del área geográfica básica (AGEB. Los resultados de los modelos de regresión indican que el índice de accesibilidad, el balance entre empleos y viviendas, el valor del suelo y las variables aproximadas de uso del suelo (proporción de trabajadores en el sector secundario y terciario muestran efectos estadísticamente significativos al explicar diferencias en los tiempos de traslado al trabajo en transporte público. Así mismo, el índice de accesibilidad, valor del suelo y la proporción de trabajadores en el sector secundario incrementan dichos tiempos en transporte privado. Los resultados tienen implicaciones en términos de políticas de usos del suelo y planeación del transporte.

  8. The role of effective mass and hand speed in the performance of kung fu athletes compared with nonpractitioners.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F

    2007-05-01

    The main goal of this article is to quantify the contribution of effective mass (me) and handspeed (shi) on the palm strike performance of kung fu athletes (kung fu group) compared with nonpractitioners (control group). All subjects were asked to strike a basketball. Hand and ball speed (sbf) were determined by high-speed video analysis. The value for me was determined by an equation that does not depend upon postimpact measurement of the hand speed. The results show that kung fu athletes had greater shi (6.67 [SD 1.42] m/s), p = 0.042), higher me (2.62 [SD 0.33] kg, p = 0.004), and greater sbf (9.00 [SD 1.89] m/s), p = 0.004) than the nonpractitioners (5.04 [SD 0.57] m/s, 1.33 [SD 0.19] kg, and 5.72 [SD 0.44] m/s, respectively). Comparing the average values obtained for me and hand and forearm mass (m), it was found that for the control group me is statistically equal to m (p = 0.917), whereas for the kung fu group me is significant greater than m (p = 0.003). It is suggested that for impacts against heavier objects, the effective mass would be the main factor to distinguish a martial arts-trained from an untrained subject.

  9. Effects of 5-FU combined compound Ginseng and Astragalus on biological behavior of human gastric cancer MGC-803 cells

    Institute of Scientific and Technical Information of China (English)

    韦尉元

    2013-01-01

    Objective To observe the in vitro effects of 5-fluorouracil(5-FU) combined Compound Ginseng and Astragalus(CGA) on the biological behaviors such as the proliferation,the cloning,apoptosis and migration of human gastric cancer MGC-803 cells. Methods The cell proliferation inhibition rate was detected by MTT assay,

  10. Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

    DEFF Research Database (Denmark)

    Buhl, Ida Kappel; Gerster, Sarah; Delorenzi, Mauro

    2016-01-01

    patients who benefitted from the addition of irinotecan to 5-FU, we used gene expression profiles based on cell lines and clinical tumor material. These profiles were applied to expression data obtained from pretreatment formalin fixed paraffin embedded (FFPE) tumor tissue from 636 stage III colon cancer...

  11. Deeply embedded objects and shocked molecular hydrogen : The environment of the FU Orionis stars RNO 1B/1C

    NARCIS (Netherlands)

    Quanz, S. P.; Henning, Th.; Bouwman, J.; Linz, H.; Lahuis, F.

    2007-01-01

    We present Spitzer IRAC and IRS observations of the dark cloud L1287. The mid-infrared ( MIR) IRAC images show deeply embedded infrared sources in the vicinity of the FU Orionis objects RNO 1B and RNO 1C, suggesting their association with a small young stellar cluster. We resolve for the first time

  12. 江淹赋的用典%The use of allusions in JIANG Yan's Fu

    Institute of Scientific and Technical Information of China (English)

    辛玲; 王卫振

    2011-01-01

    "Jiang lang cai jin" is the story of JIANG Yan,who is a famous writer of Fu.The Hen Fu and Bie Fu are the most famous masterpieces of him.In this paper,the allusions in JIANG Yan's fifteen Fu are summed up,analyzed and classified,on the basis,its features are concluded in order to provide more materials for Chinese allusion research.%"江郎才尽"典故中的主人公江淹是魏晋南北朝时期的著名赋作家,其《恨赋》与《别赋》最为著名,其中典故的运用也值得研究一番。本文主要对江淹的十五篇赋作中出现的典故进行总结,然后分类分析研究,最后得出其运用时所表现的特点,为汉语典故的研究提供更多的材料。

  13. Effect of cholesterol on behavior of 5-fluorouracil (5-FU) in a DMPC lipid bilayer, a molecular dynamics study.

    Science.gov (United States)

    Khajeh, Aboozar; Modarress, Hamid

    2014-01-01

    In this work, molecular dynamics (MD) simulations were performed to investigate the effects of cholesterol on the interaction between the hydrophilic anticancer drug, 5-FU, and fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer. Several structural and dynamical parameters of DMPC bilayers with varying amounts of cholesterol (0, 25, and 50mol%) in the presence and absence of drug molecules were calculated. Moreover, the free energy barriers for translocation of one 5-FU molecule from water to the lipid bilayer were determined by using the potential of mean force (PMF). PMF studies indicated that the location of the maximum free energy barrier was in the hydrophobic middle region of bilayer, while the minimums of the barrier were located at the hydrophilic part of bilayer at the interface with water. The minimum and maximum of the free energy profiles were independent of cholesterol concentration and suggested that the drug molecules 5-FU were accumulated in the vicinity of the polar head group of lipid bilayers. Moreover, the results showed that with increasing cholesterol concentration in the bilayer, the free energy barrier for translocation of 5-FU across the bilayer also increases which can be attributed to the condensing effect of the cholesterol on the bilayer.

  14. Assessment of surface concentrations in resorbable ocular implants: controlled drug delivery devices for 5-fluorouracil (5-FU)

    Science.gov (United States)

    Milne, Peter J.; Gautier, Sandrine; Parel, Jean-Marie A.; Jallet, Valerie

    1997-05-01

    The antineoplastic drug 5-fluorouracil (5-fluoro- 2,4,(1H,3H)-pyrimidinedione; 5-FU) has been used to control proliferation of penetrating fibroblasts and to prevent channel closure following glaucoma filtration surgery (trabeculectomy) or laser sclerectomy. Because of the toxicity of the drug, administration of low dosages slowly over time, at the site of the desired treatment, is indicated for optimum efficacy. Repeated injections of low dosages of the drug represent an undesirable intervention and may also result in unwanted toxicity to the corneal epithelium. A suitable biocompatible and resorbable polymer matrix composed of a poly (D,L-lactic-co-glycolic acid: PLGA) has been admixed with varying amounts of 5-FU and cast as shapes suitable for intracorneal implantation. Slow biodegradation of this polymer over a one to two week period has been shown to result in an acceptably slow drug release mechanism. An issue arising during the clinical evaluation of the efficacy of this drug delivery system was how best to quantify the concentration of 5-FU and its distribution spatially in the solid implant. FT-IR and FT-Raman spectroscopies distinguishes between the drug and the polymer matrix and were used to differentiate and quantitate the 5-FU concentration of the implants.

  15. TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients

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    A. Fariña-Sarasqueta

    2010-01-01

    Full Text Available Aim: Although the predictive and prognostic value of thymidylate synthase (TS expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy.

  16. Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer.

    Science.gov (United States)

    Hotta, Tsukasa; Takifuji, Katsunari; Arii, Kazuo; Yokoyama, Shozo; Matsuda, Kenji; Higashiguchi, Takashi; Tominaga, Toshiji; Oku, Yoshimasa; Yamaue, Hiroki

    2005-08-01

    l-leucovorin (LV)/5-fluorouracil (5FU) may play an important role, as an adjuvant chemotherapy, in improving the survival of patients with stage III colorectal cancer. However, severe toxicity of the chemotherapeutic agent could be fatal. Adverse effects, including bone marrow suppression, liver damage, renal damage, and glucose tolerance, were evaluated daily during 3 courses of l-LV/5FU-modified RPMI regimen adjuvant chemotherapy for 22 patients with stage III colorectal cancer. Decrease in the serum levels of neutrophils and platelets occurred in the 1st course, which became more obvious after three or four administrations of l-LV/5FU in the 1st course. Furthermore, serum levels of leukocytes, neutrophils, and platelets on the re-start day of this chemotherapy after 2-week intervals were lower than those on the start day of this chemotherapy. In the evaluation of liver damage, renal damage, and glucose tolerance; serum alanine aminotransferase level in the 2nd course, serum total bilirubin (T.Bil) level in the 1st course, and serum creatinine level in the 1st course deteriorated during the course. T.Bil levels on the re-start day of this chemotherapy after 2-week intervals were especially high compared to that on the start day. The more courses of this chemotherapy we perform, the more attention we must pay to bone marrow suppression and hyperbilirubinemia. Thus, we clarified the attentive point of side effect of l-LV/5FU adjuvant chemotherapy for colorectal cancer.

  17. Adjuvant 5FU plus levamisole in colonic or rectal cancer: improved survival in stage II and III.

    Science.gov (United States)

    Taal, B G; Van Tinteren, H; Zoetmulder, F A

    2001-11-16

    Based on the first favourable results of adjuvant therapy of 5FU plus levamisole in Dukes C colonic cancer in 1990, we conducted a prospective trial. 1029 patients were randomised to receive one year 5FU plus levamisole or no further treatment following curative surgery for stage II or III colon (n = 730) or rectal cancer (n = 299). 45% were in stage II and 55% in stage III. With a median follow-up of 4 years and 9 months a significant reduction in odds of death (25%, SD 9%, P = 0.007) was observed for those with adjuvant treatment (65% at 5 year) compared to the observation group (55%). Improved relative survival was present in stage III (56% vs 44%), and in stage II patients (78% vs 70%). In rectal cancer a non-significant difference in disease-free or overall survival was observed. Distant metastases developed in 76%, while local recurrence alone occurred in 14%. An early start of adjuvant treatment (5FU plus levamisole was 69%. Severe toxicity did not occur. In conclusion, one year 5FU plus levamisole was of benefit in stage II and III colonic cancer; in rectal cancer a significant positive effect could not be demonstrated.

  18. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach

    Institute of Scientific and Technical Information of China (English)

    Juan Huang; Jian Wei Wang; Tao Gong; Zhi Rong Zhang

    2007-01-01

    To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.

  19. Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects.

    Science.gov (United States)

    Kodama, Yukinobu; Fumoto, Shintaro; Nishi, Junya; Nakashima, Mikiro; Sasaki, Hitoshi; Nakamura, Junzo; Nishida, Koyo

    2008-05-01

    The present study was undertaken to elucidate the absorption and distribution characteristics of 5-fluorouracil (5-FU) after its application to the liver surface in rats to examine the possibility of reducing the systemic side effects of this agent. 5-FU was applied to the surface of the liver by employing a cylindrical diffusion cell. Approximately 69% of the dose was absorbed in 360 min. The time course of the change in the amount of 5-FU remaining in the diffusion cell obeyed first-order kinetics. Also, a linear relationship was observed between the apparent permeability coefficient, P app, and the reciprocal of the square root of the molecular weight of several compounds including 5-FU. The estimated P app value of 5-FU was in good agreement with the experimental value. The plasma concentration of 5-FU was low (5-FU was rapidly eliminated from the plasma and could not be detected at 120 min. In the analysis of tissue distribution, the liver was divided into three sites; the region under the diffusion cell attachment site (site 1), the treated lobe excluding site 1 (site 2), and untreated lobes (site 3). After being administered i.v., 5-FU mainly distributed in the kidney, and the concentration in the liver was significantly lower than that in kidney, spleen, or heart. After its application to the liver surface, however, 5-FU preferentially distributed at site 1, and was not detected at the other sites or in other tissues. Thus, these results suggested the possibility of a reduction in the systemic side effect of 5-FU on its application to the liver surface.

  20. The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

    Directory of Open Access Journals (Sweden)

    Kjellén Elisabeth

    2009-12-01

    Full Text Available Abstract Background In locally advanced rectal cancer, 5-Fluorouracil (5-FU-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties, oxaliplatin has recently been incorporated in many clinical chemoradiation protocols. The aim of this study was to investigate to what extent 5-FU and oxaliplatin influence the radiation (RT induced small bowel mucosal damage when given in conjunction with single or split dose RT. Methods Immune competent balb-c mice were treated with varying doses of 5-FU, oxaliplatin (given intraperitoneally and total body RT, alone or in different combinations in a series of experiments. The small bowel damage was studied by a microcolony survival assay. The treatment effect was evaluated using the inverse of the slope (D0 of the exponential part of the dose-response curve. Results In two separate experiments the dose-response relations were determined for single doses of RT alone, yielding D0 values of 2.79 Gy (95% CI: 2.65 - 2.95 and 2.98 Gy (2.66 - 3.39, for doses in the intervals of 5-17 Gy and 5-10 Gy, respectively. Equitoxic low doses (IC5 of the two drugs in combination with RT caused a decrease in jejunal crypt count with significantly lower D0: 2.30 Gy (2.10 - 2.56 for RT+5-FU and 2.27 Gy (2.08 - 2.49 for RT+oxaliplatin. Adding both drugs to RT did not further decrease D0: 2.28 Gy (1.97 - 2.71 for RT+5-FU+oxaliplatin. A clearly higher crypt survival was noted for split course radiation (3 × 2.5 Gy compared to a single fraction of 7.5 Gy. The same difference was seen when 5-FU and/or oxaliplatin were added. Conclusion Combining 5-FU or oxaliplatin with RT lead to an increase in mucosal damage as compared to RT alone in our experimental setting. No additional reduction of jejunal crypt counts was noted when both drugs were combined with single dose RT. The higher crypt survival with split dose radiation indicates a

  1. 汉代赋颂关系析论%The Relation of Han Fu and Ode

    Institute of Scientific and Technical Information of China (English)

    丁玲

    2014-01-01

    In Han dynasty , ode and Fu ( descriptive prose interspersed with verse ) were close in form,which may be the result of the latter on the former or due to the fact that the style of ode was not mature enough then and dependent on Han Fu .Ode was addressed as Fu in Han considering that Fu was more inclusive;when Fu was called ode to highlight the subject of “de-scriptive” and “beauty priority” in fu;another reason was that the two words shared some meanings.In Han,they were called “Fusong”.There are possibly three reasons:(1) the both genres are in the “six poems”;(2) they were both court literature;(3) ode was more depend-ent on Fu then .%汉代颂与赋体貌接近,这一方面和汉赋文体对颂体的影响有关,另一方面则是由于颂的文体规范尚未形成,颂论多依附赋论。汉代存在赋、颂混称和连称的现象。汉人称颂为赋,是由于汉代赋在广义上包含颂;称赋为颂,一是为强调赋中“述形容”且“美盛德”的内容,二是由于“赋”“颂”字义有相通点。汉代“赋颂”连称,原因有三:一是赋与颂并在“六诗”之中,“六诗”之名,后来多两两相合;二是由于赋、颂在汉代皆属宫廷文学,宫廷作家多赋、颂兼擅;三是汉代颂论对赋论的依附。

  2. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Directory of Open Access Journals (Sweden)

    Lyn Wadley

    Full Text Available Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone

  3. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/’hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory

    Science.gov (United States)

    2015-01-01

    Ju/’hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/’hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/’hoan hunters represents a hafting system both similar to and different from that observed at the Stone Age sites of

  4. Beetle and plant arrow poisons of the Ju|'hoan and Hai||om San peoples of Namibia (Insecta, Coleoptera, Chrysomelidae; Plantae, Anacardiaceae, Apocynaceae, Burseraceae).

    Science.gov (United States)

    Chaboo, Caroline S; Biesele, Megan; Hitchcock, Robert K; Weeks, Andrea

    2016-01-01

    The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San ("Bushmen") arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called 'click languages' in southern Africa. Beetles are used for arrow poison by at least eight San groups and one non-San group. Fieldwork and interviews with Ju|'hoan and Hai||om hunters in Namibia revealed major differences in the nature and preparation of arrow poisons, bow and arrow construction, and poison antidote. Ju|'hoan hunters use leaf-beetle larvae of Diamphidia Gerstaecker and Polyclada Chevrolat (Chrysomelidae: Galerucinae: Alticini) collected from soil around the host plants Commiphora africana (A. Rich.) Engl. and Commiphora angolensis Engl. (Burseracaeae). In the Nyae Nyae area of Namibia, Ju|'hoan hunters use larvae of Diamphidia nigroornata Ståhl. Larvae and adults live above-ground on the plants and eat leaves, but the San collect the underground cocoons to extract the mature larvae. Larval hemolymph is mixed with saliva and applied to arrows. Hai||om hunters boil the milky plant sap of Adenium bohemianum Schinz (Apocynaceae) to reduce it to a thick paste that is applied to their arrows. The socio-cultural, historical, and ecological contexts of the various San groups may determine differences in the sources and preparation of poisons, bow and arrow technology, hunting behaviors, poison potency, and perhaps antidotes.

  5. Beetle and plant arrow poisons of the Ju|’hoan and Hai||om San peoples of Namibia (Insecta, Coleoptera, Chrysomelidae; Plantae, Anacardiaceae, Apocynaceae, Burseraceae)

    Science.gov (United States)

    Chaboo, Caroline S.; Biesele, Megan; Hitchcock, Robert K.; Weeks, Andrea

    2016-01-01

    Abstract The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San (“Bushmen”) arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called ‘click languages’ in southern Africa. Beetles are used for arrow poison by at least eight San groups and one non-San group. Fieldwork and interviews with Ju|’hoan and Hai||om hunters in Namibia revealed major differences in the nature and preparation of arrow poisons, bow and arrow construction, and poison antidote. Ju|’hoan hunters use leaf-beetle larvae of Diamphidia Gerstaecker and Polyclada Chevrolat (Chrysomelidae: Galerucinae: Alticini) collected from soil around the host plants Commiphora africana (A. Rich.) Engl. and Commiphora angolensis Engl. (Burseracaeae). In the Nyae Nyae area of Namibia, Ju|’hoan hunters use larvae of Diamphidia nigroornata Ståhl. Larvae and adults live above-ground on the plants and eat leaves, but the San collect the underground cocoons to extract the mature larvae. Larval hemolymph is mixed with saliva and applied to arrows. Hai||om hunters boil the milky plant sap of Adenium bohemianum Schinz (Apocynaceae) to reduce it to a thick paste that is applied to their arrows. The socio-cultural, historical, and ecological contexts of the various San groups may determine differences in the sources and preparation of poisons, bow and arrow technology, hunting behaviors, poison potency, and perhaps antidotes. PMID:27006594

  6. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Science.gov (United States)

    Wadley, Lyn; Trower, Gary; Backwell, Lucinda; d'Errico, Francesco

    2015-01-01

    Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone Age sites of Diepkloof

  7. Quaternary alluvial fans of Ciudad Juárez, Chihuahua, northern México: OSL ages and implications for climatic history of the region

    Science.gov (United States)

    Zúñiga de León, David; Kershaw, Stephen; Mahan, Shannon

    2016-01-01

    Alluvial fans formed from sediments derived from erosion of the Juárez Mountains in northernmost México have a significant flood impact on the Ciudad Juárez, which is built on the fan system. The northern part of Ciudad Juárez is the most active; further south, older parts of the fan, upon which the rest of the city is built, were largely eroded by natural processes prior to human habitation and subsequently modified only recently by human construction. Three aeolian sand samples, collected from the uppermost (youngest) parts of the fan system in the city area, in places where human intervention has not disturbed the sediment, and constrain the latest dates of fan building. Depositional ages of the Quaternary alluvial fans were measured using Optically Stimulated Luminescence (OSL) on aeolian sands that have inter-fingered with alluvial fan material. These dates are: a) sample P1, 31 ka; b) sample P2, 41 ka; c) sample P3, 74 ka, between Oxygen Isotope Stages (OIS) 3 to 5. They demonstrate that fan development, in the area now occupied by the city, terminated in the Late Pleistocene, immediately after what we interpret to have been an extended period of erosion without further deposition, lasting from the Late Pleistocene to Holocene. The three dates broadly correspond to global glacial periods, implying that the cool, dry periods may reflect periods of aeolian transport in northern México in between phases that were wetter to form the alluvial fans. Alluvial fan margins inter-finger with fluvial terrace sediments derived from the Río Bravo, indicating an additional component of fan dissection by Río Bravo lateral erosion, presumed to be active during earlier times than our OSL ages, but these are not yet dated. Further dating is required to ascertain the controls on the fan and fluvial system.

  8. Low Impact Development Intensive Rural Construction Planning in Xu Fu Village Ningbo, China: Planning Review through Rural Resilience Perspective

    Directory of Open Access Journals (Sweden)

    Roosmayri Lovina Hermaputi

    2017-08-01

    Full Text Available Xu Fu Village Ningbo LID Intensive Rural Construction Planning is a cooperation project between Zhejiang University and Ningbo Institute of Technology which named "12th Five-Year National Science and Technology support program-the comprehensive demonstration of the key technology of the beautiful rural construction in the rapid urbanization area of the Yangtze River Delta". This plan focuses on intensive rural construction as part of rural development and construction project that applies the principles of low impact development. Xu Fu Village located in the Yangtze River Delta Region. Currently, the rural growth brings the high impact of development, as a result of rapid urbanization growth arising several issues, such as low land use efficiency, dispersed rural residence, homestead occupies more, rural roads covering over, etc. Meanwhile, Xu Fu village wishes to develop its tourism potential. Thus, the intensive rural construction should be done to avoid the severe effect. The project result hopefully can improve the quality and level of rural residential planning, design, and construction; improve their living environment; save construction land and water use; and improve energy efficiency. The aim of this study is to review the Low Impact Development (LID Intensive Rural Construction in Xu Fu Village, Ningbo City through the rural resilience perspective. This paper will describe the project plan first, then review it through rural resilience perspective. This paper will elaborate the rural resilience theory and then review the rural resiliency through two parts; the first part is identifying rural resilience in rural infrastructure development based on the criteria created by Ayyob S. and Yoshiki Y. (2014, about urban resiliency criteria, and then the second part is reviewing Xu Fu Village resilience through Arup Resilience Qualities (2012, considering three rural resilience domain (economy, ecology, and cultural.

  9. Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells.

    Science.gov (United States)

    Hakim, Luqman; Alias, Ekram; Makpol, Suzana; Ngah, Wan Zurinah Wan; Morad, Nor Azian; Yusof, Yasmin Anum Mohd

    2014-01-01

    The development of chemopreventive approaches using a concoction of phytochemicals is potentially viable for combating many types of cancer including colon carcinogenesis. This study evaluated the anti-proliferative effects of ginger and Gelam honey and its efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. Cell viability was measured via MTS (3-(4,5-dimethylthiazol-2- yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphenyl)-2H-tetrazolium) assay showing ginger inhibiting the growth of HCT 116 cells more potently (IC50 of 3mg/mL) in comparison to Gelam honey (IC50 of 75 mg/mL). Combined treatment of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL. Combination with 35 mg/mL Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells. Subsequent analysis on the induction of cellular apoptosis suggested that individual treatment of ginger and Gelam honey produced higher apoptosis than 5-FU alone. In addition, treatment with the combination of two natural compounds increased the apoptotic rate of HCT 116 cells dose- dependently while treatment of either ginger or Gelam honey combined with 5-FU only showed modest changes. Combination index analysis showed the combination effect of both natural compounds to be synergistic in their inhibitory action against HCT 116 colon cancer cells (CI 0.96 5-FU against colorectal cancer.

  10. Neo-adjuvant chemotherapy with cisplatin and short infusional 5-FU in advanced head and neck malignancies

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    Aich Ranen Kanti

    2005-01-01

    Full Text Available Background: Combination of radical surgery and radiotherapy is the standard management of head and neck malignancies. But due to considerable morbidity of surgery and associated cosmetic and functional deficiencies, often aggravated by adjuvant radiotherapy, many patients prefer only radiotherapy with its′ decreased chance of survival. Proper surgical facilities are also not accessible to most of our patients. Neo-adjuvant chemotherapy and loco-regional management by surgery and / or radiotherapy have emerged as a viable alternative. Aims: The purpose of this study is to find out the survival outcome as well as toxicity profile of Neo-adjuvant chemotherapy with cisplatin and short infusional (3 hours 5-FU followed by radiotherapy in advanced head and neck malignancies. Materials and Methods: From June 2002 to December 2003, seventy four patients with advanced head and neck malignancies were planned to be treated with Cisplatin (50 mg / sq. meter on Days 1 and 2 and 5 - FU (600 mg / sq. meter on Days 1, 2 and 3 by 3 hour infusion on Day care basis. On completion of four cycles of chemotherapy at 21 days interval, all patients were destined to receive 6000 cGy of radiotherapy to the loco - regional site. Results: At one year follow up on completion of therapy, 57% patients were alive and 31% patients were disease free. These 31% patients enjoyed a good quality of life in terms of cosmetic and functional deficits. Toxicities were moderate and easily manageable. Conclusion: The study indicated that neo-adjuvant chemotherapy with Cisplatin and short infusional 5 - FU may be delivered on day care basis and results are comparable with Cisplatin and 96 hours continuous infusional 5 - FU. Thus avoiding the continuous infusional 5 - FU, 7 to 10 days in-patient hospitalization during each cycle may be avoided which is a constrain in developing countries like us.

  11. PROMETNA VARNOST VOZNIKOV KOLES Z MOTORJEM IN MOTORNIH KOLES NA OBMOČJU POLICIJSKE UPRAVE CELJE V OBDOBJU 2000-2011

    OpenAIRE

    Aćimović, Mirjana

    2012-01-01

    Vsako leto se povečuje število voznikov koles z motorjem in motornih koles, ki postajajo vse bolj priljubljeno prevozno sredstvo med mladimi. Z rastjo števila enoslednih motornih vozil se povečuje tudi nevarnost za motoriste, ki so veliko ranljivejši od drugih udeležencev v cestnem prometu. Predmet obravnave diplomske naloge je prometna varnost voznikov koles z motorjem in motornih koles na območju policijske uprave Celje v obdobju 2000–2011. Na podlagi statistično pridobljenih podatkov smo...

  12. Entrevista a Nemesio Juárez: “en el cine revolucionario el héroe es el hombre común”

    Directory of Open Access Journals (Sweden)

    Ana Clara Tosi

    2015-09-01

    Full Text Available El cine y las declaraciones de Nemesio Juárez, presentan las particularidades de la producción cinematográfica de América Latina, de los años 60 y 70, cine comprometido y revolucionario. Nemesio, participó del Grupo de Cine Liberación que integraban Fernando “Pino” Solanas, Octavio Getino y Gerardo Vallejo; y fue uno de los realizadores que puso el cine al servicio de una organización sindical.

  13. Violencia en la ciudad, en el trabajo maquilador y la subjetividad de obreras y obreros en Ciudad Juárez

    OpenAIRE

    Sergio G. Sánchez Díaz; Patricia Ravelo Blanca; Javier Melgoza Valdivia

    2015-01-01

    Los autores observan la situación en Ciudad Juárez en los años de la gran violencia reciente en esa región (2008-2012), recuperan las condiciones históricas de violencia, como la estigmatización de los migrantes, las relaciones laborales en las maquiladoras de exportación, y los feminicidios. Actualizan toda esa situación adentrándose en el contexto urbano, observando el auge de la violencia en medio de la lucha por la conquista de la ciudad entre cárteles de la droga, al tiempo que se llevab...

  14. Subjetividades disidentes y el (des)dominio del biopoder paralegal: la producción sociocultural de los cuerpos en Ciudad Juárez, México

    OpenAIRE

    Salvador Salazar Gutiérrez

    2014-01-01

    En el escenario de violencia en el contexto de Ciudad Juárez, se viene articulan - do la tensión entre el proyecto dominante de un biopoder paralegal caracterizado por tres factores: la presencia del narcotrá¿co, la nulidad biográ¿ca de todo aquel cargado con el estigma de amenazante, así como la precarización estructural y vital de la mayoría de los habitantes de esta ciudad fronteriza. Frente a ello, se encuentra el surgimiento incipiente de una biorresistencia caracterizada por la práctica...

  15. Propuesta de un sistema de tratamiento de aguas residuales a bajo costo para la localidad de Guelatao de Juárez, Oaxaca (México)

    OpenAIRE

    Martín Fernández, Inmaculada

    2008-01-01

    En este trabajo se presenta una propuesta para el tratamiento de las aguas residuales en la localidad de Guelatao de Juárez, Oaxaca (México) basada en el uso de sistemas a bajo costo. El objetivo general del proyecto es instaurar una política de prevención primaria para la salud de dicha población de la localidad a partir de la mejora del tratamiento de sus aguas residuales, evitando así el riesgo de que se puedan producir brotes de enfermedades infecciosas y epidemias, además de disminuir...

  16. Seguridad urbana y vulnerabilidad social en Ciudad Juárez. Un modelo desde la perspectiva de análisis espacial

    OpenAIRE

    2013-01-01

    Partiendo del concepto de “seguridad urbana”, introducido por un-Habitat en 2007 dentro de la agenda de Ciudades seguras, el presente trabajo propone analizar a Ciudad Juárez, urbe considerada entre las más inseguras y violentas del país y del mundo. Se presenta el desarrollo de un índice de seguridad urbana (isu) basado en un modelo multicriterio de análisis espacial que propone identificar y explicar cómo se manifiestan territorialmente las amenazas a la seguridad urbana y su relación con l...

  17. O juízo dos súditos na república Hobbesiana = The subjects’ discretion in the Hobbesian commonwealth

    Directory of Open Access Journals (Sweden)

    Villanova, Marcelo Gross

    2011-01-01

    Full Text Available A discrição da presença do princípio de reciprocidade na formulação hobbesiana oblitera importantes dimensões na sua teoria. Entre estas, a necessidade intrínseca de que os súditos estejam instados a utilizar a sua capacidade de produzir juízos. Apresentam-se diversas circunstâncias que corroboram essa tese, o que mostra que a atividade de julgar não foi confiscada pelo soberano. Ao contrário, ela é mesmo necessária para o seu sistema

  18. Zavzetost zaposlenih na področju Dolenjske : diplomsko delo visokošolskega študija Varnost in policijsko delo

    OpenAIRE

    Kovšca, Anja

    2014-01-01

    Povzetek– Zavzetost zaposlenih na področju Dolenjske Zavzetost zaposlenih pomeni združitev predanosti, pripadnosti in produktivnosti, ki je hkrati tudi pomemben element konkurenčnosti. V teoretičnem delu naloge je pojasnjena zavzetost zaposlenih, ki se dotakne tudi zadovoljstva zaposlenih. Razčlenjeni so tudi stopnja in dejavnike zavzetosti zaposlenih. Zaključimo z vlogo vodij pri doseganju zavzetosti zaposlenih. V empiričnem delu preverimo začetna raziskovalna vprašanja, ki so zasnovana...

  19. Prevalencia de asma y otras enfermedades alérgicas en niños escolares de Ciudad Juárez, Chihuahua

    OpenAIRE

    Barraza-Villarreal Albino; Sanín-Aguirre Luz Helena; Téllez-Rojo Martha María; Lacasaña-Navarro Marina; Romieu Isabelle

    2001-01-01

    Objetivo. Determinar la prevalencia y severidad del asma, de la rinitis y del eczema en escolares. Material y métodos. Estudio transversal efectuado entre abril de 1998 y mayo de 1999 en Ciudad Juárez, Chihuahua, México, a una muestra aleatoria de 6 174 niños de 53 escuelas. Se aplicó la metodología propuesta por el International Study of Asthma and Allergies in Childhood (ISAAC) (etapas 1 y 2) para determinar la prevalencia y severidad del asma, rinitis y eczema. La información de prevalenci...

  20. Elaboración del duelo de una madre cuyo hijo trabajaba como sicario en Ciudad Juárez, Chih.

    OpenAIRE

    Rosalía Delgado Durán

    2014-01-01

    El presente trabajo es parte de una investigación cualitativa sobre el proceso de elaboración de duelo de la madre de un sicario en el contexto de una terapia Gestalt. Se utilizó para su análisis la perspectiva de las etapas del duelo de Kubler-Ross (2006:59-119). La exacerbación de la violencia generada en buena medida por pugnas entre grupos del crimen organizado en Ciudad Juárez, Chihuahua (Martínez, 2008), ha dado como resultado una gran cantidad de muertes, una de ellas es el caso que no...

  1. Elaboración del duelo de una madre cuyo hijo trabajaba como sicario en Ciudad Juárez, Chihuahua

    OpenAIRE

    Rosalía Delgado Durán

    2014-01-01

    El presente trabajo es parte de una investigación cualitativa sobre el proceso de ela - boración de duelo de la madre de un sicario en el contexto de una terapia Gestalt. Se utilizó para su análisis la perspectiva de las etapas del duelo de Kübler-Ross (2006:59- 119). La exacerbación de la violencia generada en buena medida por pugnas entre gru - pos del crimen organizado en Ciudad Juárez, Chihuahua (Martínez, 2008), ha dado como resultado una gran cantidad de muertes, una de ellas es el caso...

  2. Maquiladoras de arneses automotrices: entre la producción de clase mundial y la precariedad laboral en Juárez

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Miker Palafox

    2010-11-01

    Full Text Available This article show how the globalization process has impacted in the harness maquiladora industry in Ciudad Juárez and how job insecurity and world-class production can coexist in the production of automotive harness where two of the main local stakeholders (unions and the State are completely blurred and accomplices. The document is based mainly in the analysis of four cases of maquiladora plants producing automotive harnesses owned by world leading corporations, which concentrate over 90% of employment and harness production plants in the in the city.

  3. LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

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    Shin Jung-Young

    2010-08-01

    Full Text Available Abstract Background As EBV-associated gastric cancer has unique features that are different from EBV (- gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membrane protein 2A (LMP2A in EBV-transformed tumor cells activates the phosphatidylinositol 3-kinase (PI3K/AKT pathway, which provides a survival signal and chemo-resistance to cytotoxic anti-cancer drugs. This study was to evaluate anti-proliferative effect and cell cycle change when 5-FU and LY294002 (LY, a selective inhibitor of PI3K, were treated separately or combined with different schedules in EBV positive gastric cancer cell line, SNU-719. Methods After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT. Results When 5-FU was sequentially combined with LY, the combination index (CI value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NFκB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NFκB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (% increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone. Conclusion These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance

  4. LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.

    Science.gov (United States)

    Shin, Jung-Young; Kim, Jeong-Oh; Lee, Suk Kyeong; Chae, Hiun-Suk; Kang, Jin-Hyoung

    2010-08-13

    As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membrane protein 2A (LMP2A) in EBV-transformed tumor cells activates the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which provides a survival signal and chemo-resistance to cytotoxic anti-cancer drugs. This study was to evaluate anti-proliferative effect and cell cycle change when 5-FU and LY294002 (LY), a selective inhibitor of PI3K, were treated separately or combined with different schedules in EBV positive gastric cancer cell line, SNU-719. After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT. When 5-FU was sequentially combined with LY, the combination index (CI) value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NF kappaB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NF kappaB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (%) increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone. These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance of 5-FU via downregulation of activated p-AKT and

  5. Comercio transfronterizo y su impacto en la región de El Paso-Ciudad Juárez: Una propuesta de financiamiento de la planeación binacional

    Directory of Open Access Journals (Sweden)

    Sergio Peña

    2003-01-01

    Full Text Available El presente artículo analiza el impacto del comercio transfronterizo en la región de El Paso-Ciudad Juárez, entendido como tal el valor de las compras que los consumidores mexicanos realizan en El Paso. Los resultados muestran que el monto de las ventas al menudeo en esta ciudad en el año 2000 excedieron en 33% los valores ajustados del modelo. Este último debe interpretarse como el efecto del comercio transfronterizo. Los impuestos generados por el comercio transfronterizo suman aproximadamente 125 millones de dólares y equivalen aproximadamente a los egresos brutos totales del municipio de Ciudad Juárez en el año 2000. El artículo pone de relieve la potencialidad que tendrían esos recursos para el financiamiento del desarrollo urbano binacional de El Paso y Ciudad Juárez

  6. Los imaginarios de la movilidad en Ciudad Juárez: El Caso de la discapacidad física / Imaginary mobility in Ciudad Juárez : The case of physical disability

    Directory of Open Access Journals (Sweden)

    Ramón Leopoldo Moreno Murrieta

    2015-03-01

    Full Text Available Ciudad Juarez, a border town in northern Chihuahua, presented in its urban structure, a series of sociological processes, urban, demographic, historical, economic, cultural order that make it an area of spatial and territorial interplay of contrasts in the configuration territorial of their human settlements and the construction of individual and collective interactions. The aim of this study is to identify the processes that occur in urban mobility actors whose physical conditions have a physical disability and their visions of inhabiting the city and indicators of adaptation to time the way we live and perceive, here through the building their meanings to display their experiences in relation to the imaginary place, both in their internal motions in the settlement where they live and the journeys made by the city. To do this, a methodological strategy based on analysis of the speeches and interviews obtained actors and their experiences in the areas where they generate their daily living, using observation and photographs as complementary resources in their relationship with imaginary is proposed. Ciudad Juárez, una localidad fronteriza del norte de chihuahua, presenta en su estructura urbana, una serie de procesos de orden sociológico, urbanístico, demográfica, histórica, económica, cultural que la convierten en un espacio de interacción espacial y territorial de contrastes en la configuración territorial de sus asentamientos humanos, y la construcción de interacciones individuales y colectivas. El objetivo de este estudio es identificar los procesos de movilidad urbana que presentan actores cuyas condiciones físicas presentan una discapacidad física y su visiones de habitar la ciudad y los indicadores de adaptación en cuando a la forma de vivir y percibir, aquí a través de la construcción de sus significados para visualizar sus experiencias en relación al imaginario del lugar, tanto en sus movimientos internos en el

  7. Evaluación del proyecto solución integral de residuos sólidos Cancún, en el Municipio de Benito Juárez, Quintana Roo, México

    OpenAIRE

    Ramírez Martínez, Oscar Fernando

    2016-01-01

    El manejo de los residuos en el municipio de Benito Juárez ha enfrentado durante diferentes periodos deficiencias que han repercutido en la salud pública de los pobladores, en la imagen urbana y en los recursos naturales. Como respuesta la administración del municipio de Benito Juárez 2011-2013, propuso como política pública la descentralización del manejo de residuos sólidos urbanos, donde se incluyeron estrategias para fomentar la prevención, valorización y tratamiento, además de las etapas...

  8. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms.

    Science.gov (United States)

    Gaballah, Hanaa H; Gaber, Rasha A; Mohamed, Darin A

    2017-02-01

    Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC+5-FU, SEC+apigenin, SEC+ 5-FU+apigenin. Beclin-1 and caspases 3, 9 and JNK activities were estimated by ELISA; mRNA expression levels of the antiapoptotic gene Mcl-1 were estimated using quantitative real-time RT-PCR, while tissue malondialdehyde (MDA), glutathione peroxidase and total antioxidant capacity were evaluated spectrophotometrically. A part of the tumor was examined for histopathological and Ki-67 immunohistochemistry analysis. 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. The combination of 5-FU and apigenin had a greater effect than each of 5-FU or apigenin alone against solid Ehrlich carcinoma in mice. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to liver surface in rats.

    Science.gov (United States)

    Kodama, Yukinobu; Horishita, Miyuki; Fumoto, Shintaro; Mine, Toyoharu; Miyamoto, Hirotaka; Yoshikawa, Naoki; Hirata, Haruna; Sasaki, Hitoshi; Nakamura, Junzo; Nishida, Koyo

    2012-10-01

    Objectives  The aim was to study the effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to the liver surface in rats. Methods  5-FU solution with or without viscous additives was applied to the rat liver surface with a cylindrical diffusion cell. Then, blood and the remaining solution in the diffusion cell were collected at selected times, followed by excision of the liver. The excised liver was divided into three sites and assayed for 5-FU content. Key findings  The absorption rate of 5-FU from the liver surface was decreased in the presence of carboxymethylcellulose sodium (CMC-Na) and polyvinyl alcohol (PVA) as compared with the control. The k(a) values of PVA 15% and CMC-Na 1% were reduced to about 80 and 67% of the control. The maximum plasma concentration of 5-FU was decreased by incorporation of viscous additives. The 5-FU concentration at the diffusion cell attachment site of the liver (site 1) plateaued at 180 min in the absence of viscous additives. On the other hand, the concentration of 5-FU at site 1 increased in a time-dependent manner until 360 min in the presence of viscous additives. Conclusion  Viscous additives might be useful for retaining drugs at their application site and controlling the rate of absorption from the liver surface.

  10. Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications.

    Science.gov (United States)

    Sağir, Tuğba; Huysal, Merve; Durmus, Zehra; Kurt, Belma Zengin; Senel, Mehmet; Isık, Sevim

    2016-02-01

    In this work, super paramagnetic magnetite nanoparticles were synthesized onto/into zeolite, then loaded with anti-cancer drug 5-fluorouracil (5-FU). The physical properties of the prepared nanocomposite and drug loaded nanocomposite were characterized using different techniques. The drug loading and releasing behavior of the magnetic nanocarrier was investigated and the drug-loaded nanoparticles exhibited a sustained release of drug without any burst release phenomenon. Furthermore, 5-FU loaded MZNC were evaluated for its biological characteristics. The functional 5-FU-MZNC has been triggered intra-cellular release of the cancer therapeutic agent 5-fluorouracil (5-FU). Cytotoxic effects of 5-FU loaded MZNC on human gastric carcinoma (AGS) cells were determined by real time cell analysis and colorimetric WST-1 cell viability assay. Apoptosis of cells was further investigated by Annexin-V staining which indicates the loss of cell membrane integrity. According to our results, 5-FU-MZNC showed a concentration-dependent cell proliferation inhibitory function against AGS cells. Morphologic and apoptotic images were consistent with the cytotoxicity results. In conclusion, 5-FU loaded MZNC efficiently inhibit the proliferation of AGS cells in vitro through apoptotic mechanisms, and may be a beneficial agent against cancer, however further animal study is still required.

  11. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico.

    Science.gov (United States)

    Bird, Yelena; Staines-Orozco, Hugo

    2016-01-01

    Youth smoking trends among Latin American countries, including Mexico, are on the rise. Notably, although the high prevalence of smoking in teens has been well documented in the literature, few studies have evaluated the impact of smoking and secondhand smoke (SHS) exposure on their respiratory system. To investigate the effects of smoking and SHS exposure on the respiratory health and lung function among eighth-grade students in Juárez, Mexico. A cross-sectional study was undertaken on a sample of convenience. The study outcomes centered on evaluating 300 students' lung function by spirometry (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC], and forced mid-expiratory flow rate [FEF25%-75%]) and their respiratory health (smoking behavior and SHS exposure) by their self-reported responses to a standardized respiratory questionnaire. The study outcomes were compared among three distinct groups: 1) nonsmokers/nonexposed to SHS; 2) nonsmokers/exposed to SHS; and 3) smokers. The majority of the study participants were 14 years old (85%), females (54%), who attended eighth grade in a public school setting (56%). Approximately, half reported being of low socioeconomic status (49%) and nonsmokers/exposed to SHS (49%). The lung function parameters of smokers were found to be lower (FEV1 =62.88±10.25; FEV1/FVC =83.50±14.15; and FEF25%-75% =66.35±12.55) than those recorded for the nonsmokers/exposed to SHS (FEV1 =69.41±11.35; FEV1/FVC =88.75±15.75; and FEF25%-75% =78.90±14.65) and significantly reduced when compared to the nonsmokers/nonexposed to SHS (FEV1 =79.14±13.61; FEV1/FVC =94.88±21.88; and FEF25%-75% =87.36±17.02) (Psmoking and, to a lesser extent, exposure to SHS in adolescence leads to increased respiratory symptoms and reduction of pulmonary function test values. Public health initiatives that aim to prevent smoking initiation, assist in cessation, and lessen SHS exposure of

  12. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico

    Science.gov (United States)

    Bird, Yelena; Staines-Orozco, Hugo

    2016-01-01

    Background Youth smoking trends among Latin American countries, including Mexico, are on the rise. Notably, although the high prevalence of smoking in teens has been well documented in the literature, few studies have evaluated the impact of smoking and secondhand smoke (SHS) exposure on their respiratory system. Objective To investigate the effects of smoking and SHS exposure on the respiratory health and lung function among eighth-grade students in Juárez, Mexico. Methods A cross-sectional study was undertaken on a sample of convenience. The study outcomes centered on evaluating 300 students’ lung function by spirometry (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC], and forced mid-expiratory flow rate [FEF25%–75%]) and their respiratory health (smoking behavior and SHS exposure) by their self-reported responses to a standardized respiratory questionnaire. The study outcomes were compared among three distinct groups: 1) nonsmokers/nonexposed to SHS; 2) nonsmokers/exposed to SHS; and 3) smokers. Results The majority of the study participants were 14 years old (85%), females (54%), who attended eighth grade in a public school setting (56%). Approximately, half reported being of low socioeconomic status (49%) and nonsmokers/exposed to SHS (49%). The lung function parameters of smokers were found to be lower (FEV1 =62.88±10.25; FEV1/FVC =83.50±14.15; and FEF25%–75% =66.35±12.55) than those recorded for the nonsmokers/exposed to SHS (FEV1 =69.41±11.35; FEV1/FVC =88.75±15.75; and FEF25%–75% =78.90±14.65) and significantly reduced when compared to the nonsmokers/nonexposed to SHS (FEV1 =79.14±13.61; FEV1/FVC =94.88±21.88; and FEF25%–75% =87.36±17.02) (P<0.001). Similarly, respiratory complaints were more prevalent among smokers and those exposed to SHS when compared to nonsmokers/nonexposed to SHS. Conclusion Our findings suggest that initiation of cigarette smoking and, to a

  13. Hayabusa-2 mission target asteroid 162173 Ryugu (1999 JU3): Searching for the object's spin-axis orientation

    Science.gov (United States)

    Müller, T. G.; Ďurech, J.; Ishiguro, M.; Mueller, M.; Krühler, T.; Yang, H.; Kim, M.-J.; O'Rourke, L.; Usui, F.; Kiss, C.; Altieri, B.; Carry, B.; Choi, Y.-J.; Delbo, M.; Emery, J. P.; Greiner, J.; Hasegawa, S.; Hora, J. L.; Knust, F.; Kuroda, D.; Osip, D.; Rau, A.; Rivkin, A.; Schady, P.; Thomas-Osip, J.; Trilling, D.; Urakawa, S.; Vilenius, E.; Weissman, P.; Zeidler, P.

    2017-03-01

    The JAXA Hayabusa-2 mission was approved in 2010 and launched on December 3, 2014. The spacecraft will arrive at the near-Earth asteroid 162173 Ryugu (1999 JU3) in 2018 where it will perform a survey, land and obtainsurface material, then depart in December 2019 and return to Earth in December 2020. We observed Ryugu with the Herschel Space Observatory in April 2012 at far-infrared thermal wavelengths, supported by several ground-based observations to obtain optical lightcurves. We reanalysed previously published Subaru-COMICS and AKARI-IRC observations and merged them with a Spitzer-IRS data set. In addition, we used a large set of Spitzer-IRAC observations obtained in the period January to May, 2013. The data set includes two complete rotational lightcurves and a series of ten "point-and-shoot" observations, all at 3.6 and 4.5 μm. The almost spherical shape of the target together with the insufficient lightcurve quality forced us to combine radiometric and lightcurve inversion techniques in different ways to find the object's spin-axis orientation, its shape and to improve the quality of the key physical and thermal parameters. Handling thermal data in inversion techniques remains challenging: thermal inertia, roughness or local structures influence the temperature distribution on the surface. The constraints for size, spin or thermal properties therefore heavily depend on the wavelengths of the observations. We find that the solution which best matches our data sets leads to this C class asteroid having a retrograde rotation with a spin-axis orientation of (λ = 310°-340°; β = -40° ± 15°) in ecliptic coordinates, an effective diameter (of an equal-volume sphere) of 850 to 880 m, a geometric albedo of 0.044 to 0.050 and a thermal inertia in the range 150 to 300 J m-2 s-0.5 K-1. Based on estimated thermal conductivities of the top-layer surface in the range 0.1 to 0.6 W K-1 m-1, we calculated that the grain sizes are approximately equal to between 1 and 10

  14. Convergencia tecnológica y nacimiento de las maquiladoras de tercera generación: el caso Delphi-Juárez

    Directory of Open Access Journals (Sweden)

    Arturo Lara Rivero

    2001-01-01

    Full Text Available El objetivo de este trabajo es el de explicar el nacimiento de un moderno, inédito centro de investigación y desarrollo de auto partes electrónicas: Delphi - Juárez . La pregunta básica que guía este trabajo es la siguiente: ¿cuáles son las implicaciones de la convergencia tecnológica electrónica / automotriz sobre el número, distribución espacial y jerárquica de los proveedores? Esta convergencia tecnológica viene a revalorizar las antiguas funciones eléctricas (y tanto a los viejos proveedores de partes eléctricas maduras como a los proveedores de arneses y a insertarlas en una nueva jerarquía tecnológica con interacciones más intensas entre proveedores de arneses, léase maquiladoras del sector auto partes electrónicos / eléctricos y las empresas propiamente automotrices. Resulta imprescindible leer la formación del centro de investigación y desarrollo Delphi Juárez desde la perspectiva de los procesos de convergencia, resolución de desequilibrios tecnológicos y coevolución tecnológica del campo electrónico y automotriz.

  15. Política social, protección social y programa empleo temporal: el caso Juárez, México

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Roqueme Ramírez

    2013-01-01

    Full Text Available Este trabajo es un análisis del Programa Empleo Temporal (PET en Ciudad Juárez en el marco del concepto protección social. Para ello se indaga acerca de la política social en México como un intento de comprender hasta qué punto ha contribuido dicho programa a esta alternativa de desarrollo. En este sentido, la revisión bibliográfica se empleó como una herramienta documental y metodológica que permitió conocer otras experiencias en América Latina para situar que la problemática del desempleo y la protección constituyen aún un desafío. Ciudad Juárez no es la excepción. La indagación del PET conduce a proponer que, aunque sus efectos sean positivos temporalmente, los resultados obtenidos son limitados ya que las políticas de acción están encaminadas a solventar en su mayoría contingencias y no una sustentabilidad a mediano y largo plazo. Finalmente, se propone la creación de un índice para monitorear y evaluar el impacto del PET en términos de cobertura, del perfil de los beneficiarios y de los ingresos generados entre los beneficiados.

  16. Određivanje poligona vidljivosti kao čimbenika vrednovanja nekretnina u urbanom području na osnovi vektorskog 3D modela prostora

    Directory of Open Access Journals (Sweden)

    Hrvoje Tomić

    2010-06-01

    Full Text Available Učinkovito upravljanje prostornim resursima jedan je od glavnih čimbenika zdravoga gospodarskog rasta regije. Tehnološki napredak omogućava integraciju atributa vezanih uz prostor, stvarajući prostornu informacijsku podršku koja može servisirati sve kompleksnije društvene zajednice. Važna je komponenta tih sustava masovno vrednovanje nekretnina, posebice u urbanim područjima. U radu je, nakon objašnjenja modeliranja podataka te pohrane 3D modela prostora testnog područja u prostornu bazu podataka, opisan postupak računanja vidljivosti kao čimbenika vrednovanja nekretnina na području dijela grada Zagreba. Vidljivost je u radu predstavljena poligonom vidljivosti, dvodimenzionalnim geometrijskim likom, dobivenim presijecanjem neprekinute granice vidljivosti u svim smjerovima iz težišta objekta, uzimajući u obzir presjek horizontalne vizure i prepreka. Svakoj pojedinoj građevini na cijelom testnom području pridružen je pripadajući poligon vidljivosti, a pretpostavlja se kako je površinu tog poligona moguće korelirati s pozitivnim, odnosno negativnim utjecajem na vrijednost nekretnine. Obavljena su mjerenja brzine izvođenja funkcije računanja vidljivosti u testnom sustavu.

  17. Smoking practices, risk perception of smoking, and environmental tobacco smoke exposure among 6th-grade students in Ciudad Juárez, Mexico.

    Science.gov (United States)

    Bird, Yelena; Moraros, John; Olsen, Larry K; Forster-Cox, Sue; Staines-Orozco, Hugo; Buckingham, Robert W

    2007-02-01

    This study assessed the smoking practices, risk perception of smoking, and environmental tobacco smoke (ETS) exposure among adolescents in Ciudad Juárez, Mexico. We used a cross-sectional method to examine the smoking practices, risk perception of smoking, and ETS exposure of 6th-grade students (N=506), aged 11-13 years, attending six randomly selected middle schools. Schools were classified by school setting (i.e., public vs. private) and socioeconomic status (SES; i.e., low, middle, or high). The results indicated that 6th-grade students attending a public, low-SES school setting in Ciudad Juárez not only exhibited significantly higher rates of ETS exposure at home and in public places (p<.01) but also were more likely to have tried smoking (p<.01) and to be current smokers (p<.01), and were less likely to support a ban on smoking in public places (p<.01), compared with students who attended a private school or a public, middle- or high-SES school setting. These results provide further evidence that public health interventions to prevent initiation of smoking and to assist in smoking cessation among adolescents and to reduce their ETS exposure at home and in public need to target all school-aged students, especially those attending school in a low-SES settings.

  18. Los cambios en la estructura intraurbana de Ciudad Juárez, Chihuahua, de monocéntrica a multicéntrica

    Directory of Open Access Journals (Sweden)

    César M. Flores Fuentes

    2001-01-01

    Full Text Available El artículo tiene como objetivo analizar los cambios en la estructura intraurbana de Ciudad Juárez, Chihuahua, durante el periodo 1989-1993. Para ello se usaron los censos económicos de comercio y servicios de 1989 y 1994, el censo de población de 1990 y el conteo de población de1995, ambos a nivel de AGEB. Lo anterior fue posible mediante la construcción del índice de centralidad. En 1989 la estructura intraurbana de Ciudad Juárez mostró la presencia de dos centros principales. Dichos centros, aunque con la misma jerarquía urbana, tienen distintas funciones, como resultado de contar con ramas económicas que tienen diferentes áreas de mercado, desigual densidad poblacional y distinta capacidad de compra de sus principales consumidores. Para 1994 la ciudad siguió teniendo esos dos centros principales, aunque se crearon tres nuevos subcentros que se localizan fuera de las tradicionales áreas centrales, en zonas de fácil acceso y buena infraestructura. En este contexto, la estructura intraurbana se encuentra en proceso de convertirse de monocéntrica en multicéntrica

  19. Desenvolvimento de um Iogurte Sabor Juçaí (Euterpe edulis Martius: Avaliação Físico-química e Sensorial

    Directory of Open Access Journals (Sweden)

    Gislaine Natiele dos Santos Costa

    2015-07-01

    Full Text Available A busca constante por melhorias na qualidade de vida, saúde e bemestar dos consumidores tem levado ao desenvolvimento de novos produtos. Devido a esta influência o leite e seus derivados considerados como alimentos funcionais vêm apresentando um aumento significativo no consumo. Este trabalho apresenta o processo de desenvolvimento de um iogurte sabor juçaí, fruto da palmeira juçara (Euterpe edulis Martius. Rico em nutrientes como ferro e potássio. Este fruto é similar ao açaí fruto da palmeira Euterpe oleracea Martius, porém apresenta, segundo a literatura, maior teor de antocianinas. As antocianinas possuem alto poder antioxidante e inibem a ação de radicais livres nas células diminuindo seus efeitos ao organismo humano. No desenvolvimento do produto foram preparadas formulações contendo, respectivamente, 3%, 5% e 7% da polpa da fruta visando adquirir além de funcionalidade, melhor consistência e sabor para o produto. A aceitabilidade do produto foi avaliada por meio de análise sensorial.

  20. Patērētāju apmierinātība Latvijas tūrisma tirgū

    OpenAIRE

    Ilze Medne

    2012-01-01

    Anotācija Promocijas darba mērķis ir izpētīt tūristu kā patērētāju apmierinātības līmeni ar dažādām tūrisma produkta pazīmēm un tā ietekmi uz tūrista turpmāko patērētājuzvedību Latvijas tūrisma tirgū. Promocijas darbā ir apskatīti patērētāju apmierinātības teorētiskie aspekti, apmierinātības/ neapmierinātības izpausmes patērētājuzvedībā, kā arī svarīgākās klientu apmierinātības novērtēšanas metodes. Ir izveidots jauns tūristu apmierinātības daudzfaktoru modelis tūrisma vietām, ietverot ...

  1. Mācīšanās motivācijas pilnveidošanās skolotāju studiju programmā

    OpenAIRE

    Onosova, Anna

    2016-01-01

    Maģistra darba „Mācīšanās motivācijas pilnveidošanās skolotāju studiju programmā” aktualitāti nosaka skolotājs kā galvenā 21. gadsimta atslēgas vārds. Autore aplūko pārmaiņas izglītībā, līdz ar kurām jāmainās arī mūsdienu skolai un skolotājam. Maģistra darbs sastāv no 3 nodaļām un 6 pielikumiem. Darba izstrādē analizēti 49 literatūras un citi avoti par motivāciju, vajadzībām, mācīšanās motivāciju, pārmaiņām izglītības sistēmā un piedāvātajām skolotāju studiju programmām. Darba mērķis ir izpēt...

  2. Application of foam column as green technology for concentration of saponins from sisal (Agave sisalana and Juá (Ziziphus joazeiro

    Directory of Open Access Journals (Sweden)

    B. D. Ribeiro

    2013-12-01

    Full Text Available Saponins, molecules classified as triterpenic or steroidal glycosides, are metabolites distributed in all the plant kingdom that can be used for the production of foods, cosmetics, and pharmaceuticals, as well as in soil bioremediation. Saponins are normally extracted from natural resources with water, ethanol and/or methanol, and then concentrated by liquid-liquid partitioning with n-butanol. An alternative concentration method is with a foam column, by which the saponins can be concentrated via preferential adsorption at a gas-liquid interface. Therefore, the objective of this work was the use of a foam column for the concentration of saponins from juá and sisal, evaluating parameters such as: initial working volume in the column, saponin concentration in the extracts from juá and sisal, air flow rate, pH, Raschig rings loading and operation time. When a gradient air flow rate and 25 g of Raschig rings were used, 82.6% of the jua saponins loaded onto the system were recovered in a 3.46-fold concentrated solution after 9 h of operation. Regarding sisal saponins, a concentration factor of 1.98 was observed with 90.5% of saponin recovery during 4.5 h of operation.

  3. Ūdens skaitītāju rādījumu pārvaldības sistēma

    OpenAIRE

    Pinčuka, Elīna

    2016-01-01

    Pārvaldības sistēma “Ūdens skaitītāju rādījumu pārvaldības sistēma” ir publiska tiešsaistes sistēma, kas balstīta uz tīmekļa tehnoloģijām. Tā sniedz iespēju namu pārvaldniekiem ērtāk un pārskatāmāk pārvaldīt ūdens mērījumu datus, kā arī ļauj uzskatāmi vieglāk dzīvokļu iedzīvotājiem jeb īrniekiem iesniegt patērētā ūdens mērījumus. Projekts realizēts izmantojot Laravel 5.2 satvaru un Microsoft SQL Server datubāžu pārvaldības sistēmu. Sistēma sastāv no 6 moduļiem: namu apsaimniekotāja, objektu...

  4. Coletivos de trabalho, inserção e formação: o caso dos juízes do trabalho

    Directory of Open Access Journals (Sweden)

    Genilza Evaristo Machado

    Full Text Available O artigo propõe-se a refletir sobre os processos de inserção profissional e formação continuada de juízes do trabalho de um Tribunal localizado na Região Norte do Brasil, colocando em destaque, a partir da contribuição de algumas abordagens clínicas do trabalho, a função que os coletivos de trabalho podem desempenhar nesses processos. O artigo baseia-se em pesquisa qualitativa, da qual participaram treze juízes, por meio de entrevistas individuais semiestruturadas, examinadas pela técnica da análise de conteúdo temática. Os resultados evidenciam que a inserção na magistratura é marcada por dúvidas, receios, medos e inseguranças, e que sua formação continuada se vê prejudicada pelo aumento do volume de tarefas que consomem a jornada de trabalho, avançando em uma faixa do tempo extratrabalho. Tais dificuldades são enfrentadas na solidão ou, quando muito, com o apoio de um círculo muito restrito de pares. Sugere-se que as dificuldades seriam mais bem geridas caso os coletivos de trabalho se mostrassem mais receptivos.

  5. Globalizācijas procesu ietekme uz sociālā tīkla facebook.com lietotāju motivāciju

    OpenAIRE

    Krastiņa, Elīna

    2010-01-01

    Bakalaura darba tēma ir „Globalizācijas ietekme uz sociālā tīkla facebook.com lietotāju motivāciju”. Tā mērķis ir aplūkot globālo sociālo tīklu facebook.com kā globalizācijas izpausmju piemēru un izpētīt tā lietotāju motivāciju - vai un cik lielā mērā to ietekmē globalizācijas procesi un to izraisītās blakusparādības. Darba ietvaros apskatītas vairākas pieejas globalizācijas jēdziena skaidrojumam, kā arī apskatītas globalizācijas ietekmes un sekas – kultūras globalizācija, kosmopolītisms u. c...

  6. Rezension von: Ulf Gebken, Söhnke Vosgerau (Hg.: Fußball ohne Abseits. Ergebnisse und Perspektiven des Projekts ‚Soziale Integration von Mädchen durch Fußball‘. Wiesbaden: Springer VS 2014.

    Directory of Open Access Journals (Sweden)

    Robert Claus

    2014-12-01

    Full Text Available Seit 2006 wurden im Rahmen des vom Deutschen Fußball-Bund durchgeführten Modellprojektes „Soziale Integration von Mädchen durch Fußball“ an über 200 Standorten Schul-AGs in sogenannten Brennpunktbezirken aufgebaut. Im vorliegenden Sammelband beleuchten die Autor/-innen ausführlich die Funktion von Sport für die pädagogische Kompetenzvermittlung. Zudem erbringen sie einen umfassenden Projektbericht und leisten ein Plädoyer für die Modernisierung des Verhältnisses zwischen Schule und Vereinen, Lehrplan und Ehrenamt. Somit stellt das Buch, wie auch das Projekt, einen enorm wichtigen Beitrag zur Geschlechtergerechtigkeit im Sport dar. Gleichzeitig jedoch liest sich eine Reihe an Texten etwas zu sperrig für den Bericht einer Praxisforschung, und Begriffe im Feld der ‚Integration’ bleiben schwammig.

  7. Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells

    Directory of Open Access Journals (Sweden)

    Yukihiro Akao

    2014-01-01

    Full Text Available The dysregulation of microRNA (miRNA expression causes various kinds of diseases. Especially, alterations in miRNA expression levels are frequently observed in human tumor cells and are associated with cancer pathogenesis. Earlier we established Fluorouracil (5-FU-resistant human colon cancer DLD-1 cells (DLD-1/5FU from parental 5-FU- sensitive DLD-1 cells. In the present study, we examined the expression of miRNA in each cell line and in its extracellular microvesicles (MVs before and after treatment with 5-FU. The nascent RNAs of anti-oncogenic miR-34a and -145 labeled with EU in both cells were proved to be transferred into MVs in both cell lines. The levels of miR-34a and -145 in the cells and in their MVs were not largely different in the two cell lines, and a substantial amount of both miRNAs was secreted by both cell lines even in the steady-state condition. The exposure of both cell lines to 5-FU significantly increased the intracellular levels of miR-145 and miR-34a in the 5-FU-sensitive DLD-1 cells, whereas the level of neither miR was elevated in the DLD-1/5FU cells. Interestingly, the amount of miR-145 detected in the small MVs shed into the medium of the parental cells was reduced after the treatment with 5-FU. On the other hand, the intracellular expression of miR-34a in the DLD-1/5FU cells was down-regulated compared with that in the parental DLD-1 cells even in the steady-state condition. As to the miR-34a secreted into MVs, the increase in the level in DLD-1/5FU cells was greater than that in the parental DLD-1 cells after the treatment with 5-FU. Thus, the intra- and extracellular miR-145 and -34a were closely associated with 5-FU resistance, and the resistance was in part due to the enhanced secretion of miR-145 and -34a via MVs, resulting in low intracellular levels of both miRNAs.

  8. Study on Shi Bing: This Chapter wasn't Plagiarized from Fu-niao Fu%《鹖冠子·世兵》篇非抄袭贾谊《服鸟鸟赋》辨

    Institute of Scientific and Technical Information of China (English)

    杨兆贵

    2009-01-01

    Liu Zongyuan considered that the Shi Bing Chapter of Ho-Kuan-Tzu was plagiarized from Jia Yi's Fu-niao Fu because there were some same sentences between these two essays. However, this article would reveal that these two essays have used the same quotations from some classics in pre-Qin and Han dynasty, regarding three aspects: writing skills, literature style, authors' and works' thoughts and their historical settings. Therefore, the conclusion should be that they have the same theoretical resources, and were created in a close period. Moreover, Jia Yi wrote the Fu-niao Fu after reading the Shi Bing Chapter. The Shi Bing chapter was probably finished during early Han dynasty according to the study of Cao Mo's tale.%篇有些句子和贾谊相同,柳宗元就认为是抄袭,并而断定是伪书.本文从文体研究、编纂者的思想背景、撰写手法三方面来论证篇与都引用先秦秦汉的典籍,不能证明篇抄袭.相反,两者所反映的思想却有共同的时代背景,且思想重点不同.另外,篇前部分记载曹沫一事,与后部分内容无涉.本文考证曹沫一事,推论本篇写成于战国末期与汉初之间.

  9. Comparative study of microleakage about GC FU ji IX glass ionomer and silver glass ionomer%GC FU ji IX玻璃离子和银粉玻璃离子微渗漏的对比研究

    Institute of Scientific and Technical Information of China (English)

    刘军

    2012-01-01

    目的 比较GC FU ji IX玻璃离子和银粉玻璃离子充填材料的边缘封闭性.方法 染料法检测两种材料充填离体双尖牙10 d、20 d和30 d后的染料渗透情况,进行统计学分析.结果 10 d和20 d两组比较无统计学差异(P>0.05);30 d比较有统计学差异(P<0.05),GC FU ji IX玻璃离子的边缘封闭性好于银粉玻璃离子.结论 对于乳牙龋齿及不直接承受抗压部位的恒牙龋齿来说,GC FU ji IX玻璃离子是一种理想的充填材料,值得临床推广使用.

  10. Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma.

    Science.gov (United States)

    Dai, Wei; Gao, Quangen; Qiu, Jianping; Yuan, Jianmao; Wu, Guoliang; Shen, Genhai

    2016-05-01

    Quercetin (Q), a flavonoid compound, which is obtained in variety of fruits, seeds, and vegetables, has been reported to possess many pharmacological properties including cancer-preventive and anticancer effects. However, studies on the anticancer effects and underlying mechanisms of Q in human hepatocellular carcinoma (HCC) are still limited. The present study is conducted to investigate the anticancer efficacy and adjuvant chemotherapy action of Q in HCC. HCC cell lines HepG2 and SMCC-7721 were treated with different concentrations of Q. The antiproliferative effects of Q were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and the apoptosis and cell cycle dynamics were assessed by flow cytometry; the expression of apoptosis-associated proteins were evaluated by Western blot and immunohistochemistry staining; the tumor growth in vivo was evaluated in a xenograft mouse model. Our results showed that Q effectively inhibited human HCC cell proliferation and induced apoptosis by upregulating the expression of Bad and Bax and downregulating the expression of Bcl-2 and Survivin in vitro. Furthermore, Q obviously inhibited the tumor growth and enhanced the 5-fluorouracil (5-FU) therapeutic efficacy in vitro and in vivo. Taken together, our findings highlight that Q effectively inhibited the growth of tumor and enhanced the sensitivity to thermotherapy, indicating Q is a potential treatment option for HCC.

  11. X-ray emission from an FU Ori star in early outburst: HBC 722

    CERN Document Server

    Liebhart, Armin; Skinner, Stephen; Green, Joel

    2014-01-01

    Aims: We conducted the first X-ray observations of the newly erupting FU~Ori-type outburst in HBC~722 (V2493 Cyg) with the aim to characterize its X-ray behavior and near-stellar environment during early outburst. Methods: We used data from the \\XMM\\ and \\CXO\\ X-ray observatories to measure X-ray source temperatures and luminosities as well as the gas column densities along the line of sight toward the source. Results: We report a \\CXO\\ X-ray detection of HBC~722 with an X-ray luminosity of $L_{\\rm X}\\approx 4\\times 10^{30}~\\mathrm{ergs~s}^{-1}$. The gas column density exceeds values expected from optical extinction and standard gas-to-dust ratios. We conclude that dust-free gas masses are present around the star, such as strong winds launched from the inner disk, or massive accretion columns. A tentative detection obtained by \\XMM\\ two years earlier after an initial optical peak revealed a fainter X-ray source with only weak absorption.

  12. V346 Normae: first post-outburst observations of an FU Orionis star

    Science.gov (United States)

    Kraus, S.; Caratti o Garatti, A.; Garcia-Lopez, R.; Kreplin, A.; Aarnio, A.; Monnier, J. D.; Naylor, T.; Weigelt, G.

    2016-10-01

    During their formation phase, stars gain most of their mass in violent episodic accretion events, such as observed in FU Orionis (FUor) and EXor stars. V346 Normae is a well-studied FUor that underwent a strong outburst beginning around 1980. Here, we report on photometric and spectroscopic observations, which show that the visual/near-infrared brightness has decreased dramatically between the 1990s and 2010 (ΔR ≈ 10.9 mag, ΔJ ≈ 7.8 mag and ΔK ≈ 5.8 mag). The spectral properties of this fading event cannot be explained by variable extinction alone, but indicate a drop in accretion rate by two to three orders of magnitude. This is the first time that a member of the FUor class has been observed to switch to a very low accretion phase. Remarkably, in the last few years (2011-2015) V346 Nor has brightened again at all near-infrared wavelengths, indicating the onset of a new outburst event. The observed behaviour might be consistent with the clustered luminosity bursts that have been predicted by recent gravitational instability and fragmentation models for the early stages of protostellar evolution. Given V346 Nor's unique characteristics (concerning outburst duration, repetition frequency and spectroscopic diagnostics), our results also highlight the need to revisit the FUor/EXor classification scheme.

  13. Kung fu training improves physical fitness measures in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael R; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 +/- 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37-2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  14. Electromiographic and kinematic characteristics of Kung Fu Yau-Man palm strike.

    Science.gov (United States)

    Neto, O P; Magini, Marcio

    2008-12-01

    A kinematic and electromyographic analysis of Kung Fu (KF) Yau-Man palm strikes without impact is presented. An empirical model applied to data obtained by a high-speed camera describes the kinematic characteristics of the movement. The electromyographic patterns of the biceps brachii, brachioradialis and triceps brachii muscles were studied during the strike in the time (root mean square) and frequency (wavelet transform) domains. Eight KF practitioners participated in the investigation. A wooden board was placed in front of the subjects, and they were asked to perform the strike imagining a target above the board. The results show that the Yau-Man KF palm strike has very similar kinematic characteristics to a simple moderate speed elbow extension movement. All practitioners positioned themselves in relation to the wooden board in a way to achieve their highest hand speeds in the instant their hands crossed the board. The analyses of the electromyography data shows a well developed muscle coordination of the practitioners in agreement with kinematic results. The results of this paper are important not only for improving the performance of practitioners but also to demonstrate the applicability of KF in the process of motor control development.

  15. Layered inorganic nanocomposites: a promising carrier for 5-fluorouracil (5-FU).

    Science.gov (United States)

    Kevadiya, Bhavesh D; Patel, Tapan A; Jhala, Devendrasinh D; Thumbar, Rahul P; Brahmbhatt, Harshad; Pandya, Maharshi P; Rajkumar, Shalini; Jena, Prasant K; Joshi, Ghanshyam V; Gadhia, Pankaj K; Tripathi, C B; Bajaj, Hari C

    2012-05-01

    We report here the intercalation of 5-fluorouracil (5-FU), an anticancer drug in interlayer gallery of Na(+) clay (Montmorillonite, MMT), with the assistance of biopolymer (chitosan, CS). The X-ray diffraction patterns, thermal and spectroscopic analyses indicated the drug intercalation into the clay interlayer space in support of CS and stabilized in the longitudinal monolayer by electrostatic interaction. In vitro drug release showed controlled release pattern. The genotoxic effect of drug was in vitro evaluated in human lymphocyte cell culture by comet assay, and results indicated significant reduction in DNA damage when drug was intercalated with clay and formulated in composites. The results of in vitro cell viability assay in cancer cells pointed at decreased toxicity of drug when encapsulated in Na(+)-clay plates than the pristine drug. In vivo pharmacokinetics, biodistribution, hepatotoxicity markers, e.g., SGPT and SGOT, and liver/testicular histology in rats showed plasma/tissue drug levels were within therapeutic window as compared to pristine drug. Therefore, drug-clay hybrid and composites can be of considerable value in chemotherapy of cancer with reduced side effects.

  16. Concomitant chemoradiotherapy with CDDP and 5FU for nasopharyngeal carcinoma. The initial evaluation and side effects

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Yousuke; Suzuki, Haruhiko; Shigehara, Takeo; Omura, Ken; Shimada, Fumiyuki; Hatano, Kazuo; Sekiya, Yuichi; Togawa, Takashi [Chiba Cancer Center Hospital (Japan)

    1998-03-01

    Concomitant chemoradiotherapy with CDDP and 5FU was given to 18 patients with nasopharyngeal carcinoma during January 1994-October 1996. One and 17 were in Stages III-IV respectively. None had distant metastasis. The median duration of follow-up of all patients was 23.5 months (6-45). Objective response (CR+PR) of the primary lesion and the regional nodes was 18/18 (100%), whereas CR was 2/18 (11%). CR+PR and CR at the primary lesion were 18/18 (100%) and 5/18 (28%) respectively. Two patients died of disease at T site. One patient was alive with disease. The remaining 15 (83%) patients were relapse free alive. There were 2 relapses, 1 at T+M, and 1 at T+N sites. Side effects, especially myelosuppression and mucositis, were severe. Leukopenia and mucositis in grade 3-4 were 78% and 89% respectively. In conclusion, this regimen has been effective in short term follow-up. However, because of severe side effects, further modifications are required. Long term follow-up are required to define final effectiveness of this regimen. (author)

  17. EL MORFEMA -FU DEL MAPUDUNGUN: LA CODIFICACIÓN GRAMATICAL DEL ANTIPERFECTO

    Directory of Open Access Journals (Sweden)

    Guillermo Soto

    2015-07-01

    Full Text Available El perfecto es un aspecto de perspectiva retrospectiva que codifica la vigencia en el momento de habla de una eventualidad anterior. El presente trabajo propone la existencia de una categoría semántica y gramatical de antiperfecto que, en contraste con el perfecto, codifica la no vigencia en el momento de habla de una eventualidad pasada. Debido a que, al igual que el perfecto, el antiperfecto es sensible a la vigencia de una eventualidad anterior en el momento de habla, proponemos que se trata de un segundo tipo de aspecto de perspectiva retrospectiva. Tras revisar las nociones de perfecto en Comrie (1976, Dik (1997 y Nishiyama y Koenig (2010 y la noción de pasado discontinuo en Plungian y Van der Auwera (2006, se observa el modo en que la categoría propuesta se realiza, codificada gramaticalmente, en la lengua mapuche, mediante el morfema -fu, con especial énfasis en su caracterización semántico-pragmática, su relación con la aktionsart y el papel del contexto en su interpretación.

  18. TraditionalChinesemedicineKangXian Fu FangⅠis effective for prophylaxis and treatmentofalcoholicliverdiseaseinrats

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hui Lv; Li-Ping Zhou; Dong-Ping Liu; Ying Wang; Bing-Yuan Wang; Bao-Yu Fu; Min Song; Chun-Rong Liu

    2007-01-01

    BACKGROUND:Reversal of liver ifbrosis is one of the key steps in the prevention and treatment of alcoholic liver disease (ALD), but the mechanism is unknown. This study was to investigate the effects of the Chinese medicine Kang Xian Fu Fang Ⅰ (KXⅠ) on prophylaxis and treatment of ALD in rats and its possible mechanism of action. METHODS: Eighty male Wistar rats were randomly divided into four groups: normal control; ALD model;treatment of ALD with KXⅠ; and prophylaxis of ALD by KXⅠ. At the end of 4, 8, 12 and 16 weeks, ifve rats from each group were anesthetized and their livers were removed for pathological studies using hematoxylin-eosin and Masson stain, immunohistochemical studies, and lfow cytometry for matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). Blood samples were taken for hyaluronic acid (HA) assay. RESULTS: Serum HA level and liver collagen content were lower in the groups given KXⅠfor prophylaxis and treatment than in ALD model group (P CONCLUSIONS:KXⅠcan effectively inhibit or reverse the course of ALD. This may be attributable to its capacity to inhibit the expression of MMP-2 and MMP-9.

  19. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

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    Sare Andalib

    2012-01-01

    Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  20. Multi-Model Grand Ensemble Hydrologic Forecasting in the Fu River Basin Using Bayesian Model Averaging

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    Bo Qu

    2017-01-01

    Full Text Available Statistical post-processing for multi-model grand ensemble (GE hydrologic predictions is necessary, in order to achieve more accurate and reliable probabilistic forecasts. This paper presents a case study which applies Bayesian model averaging (BMA to statistically post-process raw GE runoff forecasts in the Fu River basin in China, at lead times ranging from 6 to 120 h. The raw forecasts were generated by running the Xinanjiang hydrologic model with ensemble forecasts (164 forecast members, using seven different “THORPEX Interactive Grand Global Ensemble” (TIGGE weather centres as forcing inputs. Some measures, such as data transformation and high-dimensional optimization, were included in the experiment after considering the practical water regime and data conditions. The results indicate that the BMA post-processing method is capable of improving the performance of raw GE runoff forecasts, yielding more calibrated and sharp predictive probability density functions (PDFs, over a range of lead times from 24 to 120 h. The analysis of percentile forecasts in two different flood events illustrates the great potential and prospects of BMA GE probabilistic river discharge forecasts, for taking precautions against severe flooding events.

  1. Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model

    Science.gov (United States)

    Zeng, Li; Xiao, Cai Zhi; Deng, Zi Ting

    2017-01-01

    Fu Yuan Capsule (FYC) has been clinically used for osteoarthritis (OA) and its related diseases for many years in China. However, its pharmacological mechanism remains unclear. This study aimed to investigate the potential chondroprotective effects of FYC on articular cartilage. Rat OA model was induced by anterior cruciate ligament transection. A group of rats was treated with FYC for 12 weeks. Joint structure, types I and II collagen, and proteoglycan were evaluated by histological examination. The expression of C-terminal crosslinking telopeptide of type II collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin E2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor κB ligand were detected. Treatment with FYC could protect against articular cartilage injury. FYC treatment significantly decreased the extracellular matrix degradation factors and inflammatory mediators. Moreover, articular cartilage protective factors were increased in the FYC group. The current finding suggests that FYC protects articular cartilage in a rat OA model through various ways. Thus, it may be an effective agent for OA treatment. PMID:28167976

  2. SED analysis of class I and class II FU Orionis stars

    CERN Document Server

    Gramajo, Luciana V; Gómez, Mercedes

    2014-01-01

    FU Orionis stars (FUORS) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUORS in an homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUORS stage. We modeled the SEDs of 24 of the 26 currently known FUORS, using the radiative transfer code of Whitney et al (2003b). We compare our models with those obtained by Robitaille et al. (2007) for Taurus class II and I sources in quiescence periods, by calculating the cumulative distribution of the different parameters. FUORS have more massive disks: we find that $\\sim80\\%$ of the disks in FUORS are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ~ 1.e-7 Msun/yr vs ~ 1.e-5 Msun/yr for standard YSOs (young stellar o...

  3. V346 Normae: First post-outburst observations of an FU Orionis star

    CERN Document Server

    Kraus, Stefan; Garcia-Lopez, Rebeca; Kreplin, Alexander; Aarnio, Alicia; Monnier, John D; Naylor, Tim; Weigelt, Gerd

    2016-01-01

    During their formation phase stars gain most of their mass in violent episodic accretion events, such as observed in FU Orionis (FUor) and EXor stars. V346 Normae is a well-studied FUor that underwent a strong outburst beginning in $\\sim1980$. Here, we report photometric and spectroscopic observations which show that the visual/near-infrared brightness has decreased dramatically between the 1990s and 2010 (${\\Delta}R\\approx10.9^{\\rm m}$, ${\\Delta}J\\approx7.8^{\\rm m}$, ${\\Delta}K\\approx5.8^{\\rm m}$). The spectral properties of this fading event cannot be explained with variable extinction alone, but indicate a drop in accretion rate by 2-3 orders of magnitude, marking the first time that a member of the FUor class has been observed to switch to a very low accretion phase. Remarkably, in the last few years (2011-2015) V346 Nor has brightened again at all near-infrared wavelengths, indicating the onset of a new outburst event. The observed behaviour might be consistent with the clustered luminosity bursts that h...

  4. Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

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    Hai-Lang He

    2016-01-01

    Full Text Available Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK, an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC. Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells (LECs play a key role in the lymphangiogenesis. To assess the activity of stromal cell-derived factor-1 (SDF-1 and the coeffect of SDF-1 and vascular endothelial growth factor-C (VEGF-C on the formation and migration of LECs and clarify the inhibitory effects of JFK on the LECs, the LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs, and JFK-containing serums were prepared from rats. SDF-1 and VEGF-C both induced the differentiation of CD34+/VEGFR-3+ EPCs towards LECs and enhanced the LECs migration. Couse of SDF-1 and VEGF-C displayed an additive effect on the LECs formation but not on their migration. JFK inhibited the formation and migration of LECs, and the inhibitory effects were most probably via regulation of the SDF-1/CXCR4 and VEGF-C/VEGFR-3 axes. The current finding suggested that JFK might inhibit NSCLC through antilymphangiogenesis and also provided a potential to discover antilymphangiogenesis agents from natural resources.

  5. FU Orionis outbursts, preferential recondensation of water ice, and the formation of giant planets

    Science.gov (United States)

    Hubbard, Alexander

    2017-02-01

    Ices, including water ice, prefer to recondense on to preexisting nuclei rather than spontaneously forming grains from a cloud of vapour. Interestingly, different potential recondensation nuclei have very different propensities to actually nucleate water ice at the temperatures associated with freeze-out in protoplanetary discs. Therefore, if a region in a disc is warmed and then recooled, water vapour should not be expected to refreeze evenly on to all available grains. Instead, it will preferentially recondense on to the most favorable grains. When the recooling is slow enough, only the most favorable grains will nucleate ice, allowing them to recondense thick ice mantles. We quantify the conditions for preferential recondensation to rapidly create pebble-sized grains in protoplanetary discs and show that FU Orionis type outbursts have the appropriate cooling rates to drive pebble creation in a band about 5 au wide outside of the quiescent frost line from approximately Jupiter's orbit to Saturn's (about -10 au). Those pebbles could be of the appropriate size to proceed to planetesimal formation via the Streaming Instability, or to contribute to the growth of planetesimals through pebble accretion. We suggest that this phenomenon contributed to the formation of the gas giants in our own Solar system.

  6. Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC-MS based metabolomics.

    Science.gov (United States)

    Xu, Jie; Hu, Feng-Lin; Wang, Wei; Wan, Xiao-Chun; Bao, Guan-Hu

    2015-11-01

    Fu brick tea (FBT) is a unique post-fermented tea product which is fermented with fungi during the manufacturing process. In this study, we investigated the biochemical compositional changes occurring during the microbial fermentation process (MFP) of FBT based on non-targeted LC-MS, which was a comprehensive and unbiased methodology. Our data analysis took a two-phase approach: (1) comparison of FBT with other tea products using PCA analysis to exhibit the characteristic effect of MFP on the formation of Fu brick tea and (2) comparison of tea samples throughout the MFP of FBT to elucidate the possible key metabolic pathways produced by the fungi. Non-targeted LC-MS analysis clearly distinguished FBT with other tea samples and highlighted some interesting metabolic pathways during the MFP including B ring fission catechin. Our study demonstrated that those fungi had a significant influence on the biochemical profiles in the FBT and consequently contributed to its unique quality.

  7. Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer

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    Ankita Gupta

    2015-09-01

    Full Text Available The work was aimed at developing novel enteric coated HPMC capsules (ECHC plugged with 5 Florouracil (5-FU loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content on the dependent variables (Particle size, %EE & % CDR were determined. The optimized microsponges (F4 were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100 and/ or Eudrgit S 100 (Ed-S 100 in different proportions. In vitro release study of ECHC was performed in various release media sequentially SGF for 2 h, followed by SIF for the next 6 h and then in SCF (in the presence and absence of pectinase enzyme for further 16 h. Drug release was retarded on coating with EdS-100 in comparison to blend of EdS-100: EdL-100 coating. The percentage of 5-FU released at the end of 24 h from ECHC 3 was 97.83 ± 0.12% in the presence of pectinase whereas in control study it was 40.08 ± 0.02% drug. The optimized formulation was subjected to in vivo Roentgenographic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon targeted capsules. Pharmacokinetic studies in New Zealand white rabbits were conducted to determine the extent of systemic exposure provided by the developed formulation in comparison to 5-FU aqueous solutions. Thus, enteric coated HPMC capsules plugged with 5-FU loaded microsponges and calcium pectinate beads proved to be promising dosage form for colon targeted drug delivery to treat colorectal cancer.

  8. Combined MTX{center_dot}5-FU{center_dot}CDGP for the treatment of head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sakoda, Takema; Kitano, Hiroya [Tottori Univ., Yonago (Japan). Faculty of Medicine; Saitoh, Yuko; Ikeda, Hiroki; Dake, Yoshihiro; Enomoto, Tadao [Japanese Red Cross Society Wakayama Medical Center (Japan); Seno, Satoshi [Shiga Univ. of Medical Science, Otsu (Japan); Kawano, Atsushi [Tokyo Medical Coll. (Japan)

    2003-05-01

    Combination chemotherapy including 5-fluorouracil (5-FU) and nedaplatin (CDGP) with methotrexate (MTX) and leucovorin (LV) was administered for modulation in patients with head and neck cancer. We treated 19 patients with MTX{center_dot}5-FU{center_dot}CDGP consisting of 150 mg/body of MTX on day 1 followed by a 3-day continuous infusion of 5-FU at 3,500 mg/m{sup 2} and 17 injections of LV at 15 mg and infusion of CDGP at 100 mg/m{sup 2}. Six patients had recurrent head and neck cancer, and 13 had newly diagnosed disease. Eleven of the new patients were concurrently treated with radiation therapy. Treatment-associated toxicity was significant, including mucositis and myelosuppression, but acceptable. Sixteen patients were eligible for evaluation of response. The overall complete response rate was 75.0% (12/16). Patients treated with radiotherapy had a 90.0% (9/10) overall complete response rate. (author)

  9. Proliferation rate but not mismatch repair affects the long-term response of colon carcinoma cells to 5FU treatment.

    Science.gov (United States)

    Choudhary, B; Hanski, M L; Zeitz, M; Hanski, C

    2012-07-01

    The role of mismatch repair (MMR) in the response of colon carcinoma cells to 5-fluorouracil (5FU) is not well understood. In most of the in vitro studies only short-term response was investigated. We focussed here on the influence of MMR status on the mechanism of the short- and long-term response to clinically relevant 5FU concentrations by using isogenic or semiisogenic cell line pairs expressing/nonexpressing the hMLH1 protein, an important component of the MMR system. We show that the lower survival of MMR-proficient than of MMR-deficient cells in the clonogenic survival assay is due to a more frequent early cell arrest and to subsequent senescence. By contrast, the long-term cell growth after treatment, which is also affected by long-term arrest and senescence, is independent from the MMR status. The overall effect on the long-term cell growth is a cumulative result of cell proliferation rate-dependent growth inhibition, apoptosis and necrotic cell death. The main long-term cytotoxic effect of 5FU is the inhibition of growth while apoptosis and the necrotic cell death are minor contributions.

  10. Adverse immunoregulatory effects of 5FU and CPT11 chemotherapy on myeloid-derived suppressor cells and colorectal cancer outcomes.

    Science.gov (United States)

    Kanterman, Julia; Sade-Feldman, Moshe; Biton, Moshe; Ish-Shalom, Eliran; Lasry, Audrey; Goldshtein, Aviya; Hubert, Ayala; Baniyash, Michal

    2014-11-01

    Colorectal cancer is associated with chronic inflammation and immunosuppression mediated by myeloid-derived suppressor cells (MDSC). Although chemotherapy reduces tumor burden at early stages, it tends to have limited effect on a progressive disease, possibly due to adverse effects on the immune system in dictating disease outcome. Here, we show that patients with advanced colorectal cancer display enhanced MDSC levels and reduced CD247 expression and that some conventional colorectal cancer chemotherapy supports the immunosuppressive tumor microenvironment. A FOLFOX combined therapy reduced immunosuppression, whereas a FOLFIRI combined therapy enhanced immunosuppression. Mechanistic studies in a colorectal cancer mouse model revealed that FOLFIRI-like therapy including the drugs CPT11 and 5-fluorouracil (5FU) damaged host immunocompetence in a manner that limits treatment outcomes. CPT11 blocked MDSC apoptosis and myeloid cell differentiation, increasing MDSC immunosuppressive features and mouse mortality. In contrast, 5FU promoted immune recovery and tumor regression. Thus, CPT11 exhibited detrimental immunoregulatory effects that offset 5FU benefits when administered in combination. Our results highlight the importance of developing therapeutic regimens that can target both the immune system and tumor towards improved personalized treatments for colorectal cancer.

  11. Experimental Study on the Mechanism of Protective Effect of Free Fu on Gut-derived Endotoxin-Mediated Lung Damage

    Institute of Scientific and Technical Information of China (English)

    李道本; 杨胜兰; 陈瑞

    2004-01-01

    The effect of tumor necrosis factor-α (TNF-α) on endotoxin (ET)-mediated lung damage caused by incomplete ligation of large intestine and the influence of free Fu on the expression of TNF-α mRNA were explored. Forty SD rats were randomly divided into 4 groups: normal control group, model group, ligation group and treatment group (n=10 in each group). The models were made by the method of partly ligating the rectum outside the body. The plasma level of lipopolysaccaride was measured by dynamic nephelo metric method and the serum level of TNF-α was detected by the method of radioactive immunity. The expression of TNF-α mRNA in lung tissue was detected by RT-PCR method. The results were compared among the 4 groups. The results showed the plasma levels of ET and serum TNF-α in the model group and the expression of TNF-α mRNA in the lung tissues were remarkably higher than those in the normal control group (P<0.01). After the treatment of free Fu, all of the above indexes in the treatment group were all decreased as compared with model group (all P<0.01), and the damage to lung was alleviated. It was concluded that TNF-α might play a very important role in the ET-mediated lung damage caused by incomplete ligation of large intestine, free Fu could protect the lung from damage.

  12. Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

    Science.gov (United States)

    Cassidy, J; Douillard, J-Y; Twelves, C; McKendrick, J J; Scheithauer, W; Bustová, I; Johnston, P G; Lesniewski-Kmak, K; Jelic, S; Fountzilas, G; Coxon, F; Díaz-Rubio, E; Maughan, T S; Malzyner, A; Bertetto, O; Beham, A; Figer, A; Dufour, P; Patel, K K; Cowell, W; Garrison, L P

    2006-01-01

    Oral capecitabine (Xeloda®) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK. PMID:16622438

  13. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Chen M

    2013-11-01

    Full Text Available Mingrong Cheng,1,2,* Xiaoyan Gao,3,* Yong Wang,4,* Houxiang Chen,5 Bing He,6 Yingchun Li,2 Jiang Han,1 Zhiping Zhang11Department of General Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, People’s Republic of China; 2Department of Endoscopy, 3Department of Plastic Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, People's Republic of China; 4School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, People’s Republic of China; 5Zhejiang Huafon Fiber Research Institute, Zhejiang Huafon Spandex Co, Ltd, Wenzhou, People’s Republic of China; 6Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, People's Republic of China *These authors equally contributed to this research Abstract: Nanoparticle drug delivery systems using polymers hold promise for clinical applications. We synthesized dual-ligand modified chitosan (GCGA nanoparticles using lactic acid, glycyrrhetinic acid, and chitosan to target the liver in our previous studies. We then synthesized the GCGA/5-FU nanoparticles by conjugating 5-fluorouracil (5-FU onto the GCGA nanomaterial, which had a mean particle size of 239.9 nm, a polydispersity index of 0.040, a zeta potential of +21.2 mV, and a drug loading of 3.90%. GCGA/5-FU nanoparticles had good slow release properties, and the release process could be divided into five phases: small burst release, gentle release, second burst release, steady release, and slow release. Inhibitory effects of GCGA/5-FU on tumor cells targeted the liver, and were time and dose dependent. GCGA nanoparticles significantly prolonged the efficacy of 5-FU on tumor cells, and alleviated the resistance of tumor cells to 5-FU. GCGA/5-FU nanoparticles were mostly concentrated in the liver, indicating that the GCGA nanoparticles were liver targeting. GCGA/5-FU nanoparticles significantly suppressed tumor growth in orthotopic liver transplantation mouse model, and improved

  14. Research Progress on 5-FU Derivatives%5-氟尿嘧啶及其衍生物的研究进展

    Institute of Scientific and Technical Information of China (English)

    袁吉; 倪孟祥

    2012-01-01

    5-FU is an antimetabolite, which possesses activity against a wide range of solid tumors. The main mechanism of 5-FU is interfering with DNA synthesis and mRNA translation. However,because of the nonspecific cytotoxicity of 5-FU,the patients display several side effects. Numerous modifications of the 5-FU structure have been performed in order to overcome these disadvantages. In this paper,the mechanism and pharmacokinetics of 5-FU are briefly introduced, then several 5-FU derivatives including oral 5-FU prodrugs are presented ,finally the new innovative methods of increasing bioavailability of 5-FU and derivatives are described. All these will provide the theoretical basis for rational administration.%尿嘧啶的氟化类似物5-FU是一种抗代谢物,它对很多实体肿瘤有较好活性.5-FU抗肿瘤活性是通过干扰DNA合成和mRNA翻译来实现的.然而,由于5-FU具有非特异性细胞毒性,故采用5-FU治疗的患者表现出多种副作用.为了改善这些缺点,研究者们对5-FU的结构展开了大量的修饰工作.文章综述了5-FU的作用机理以及药代动力学情况,介绍了5-FU的几种新型修饰衍生物.最后,对提高5-FU衍生物生物利用度的研究进展进行了综述,为5-FU衍生药物的合理使用提供了理论依据.

  15. Inhibitory effect of sil ibinin combined with 5-FU treatment on mal ignant biological behaviors of gastric cancer cell l ines MGC803%水飞蓟宾联合5-FU 对胃癌细胞株 MGC803恶性生物学行为的抑制作用研究

    Institute of Scientific and Technical Information of China (English)

    王阳; 李昌林

    2016-01-01

    目的::研究水飞蓟宾联合5-FU 处理对胃癌细胞株 MGC803恶性生物学行为的抑制作用.方法:培养胃癌细胞株 MGC803,分为 NC 组、5-Fu 组、SB+5-Fu 组并用不同条件进行处理,检测凋亡细胞数目、侵袭细胞数目以及增殖、侵袭相关基因的表达量.结果:处理后6h、12h、18h、24h 时,5-Fu 组、SB+5-Fu 组凋亡细胞的数目显著多于 NC 组、侵袭数目显著少于 NC 组,SB+5-Fu 组凋亡细胞的数目显著多于5-Fu 组、侵袭数目显著少于5-Fu 组(P <0.05);5-Fu 组、SB+5-Fu 组细胞中 Vav3、PTP1B、GOLPH3、RUNX3、Sipa1、UbcH10、NEDD9、Mig-7、CD157、AEP、Galectin-1的 mRNA 含量低于 NC组(P <0.05);SB+5-Fu 组细胞中 Vav3、PTP1B、GOLPH3、UbcH10、NEDD9、Mig-7、CD157、AEP、Galectin-1的 mRNA 含量低于5-Fu 组(P <0.05),RUNX3、Sipa1的 mRNA 含量与5-Fu 组差异无统计学意义(P >0.05).结论:与5-FU 单药处理相比,水飞蓟宾联合5-FU 处理能够更为有效的促进胃癌细胞凋亡、抑制胃癌细胞侵袭、调节增殖和侵袭相关基因的表达.%Objective:To study the inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803.Methods:Gastric cancer cell lines MGC803 were cultured,divided into NC group,5-Fu group and SB+5-Fu group and treated with different conditions,and then the number of apoptotic cells,the num-ber of invasive cells as well as the expression of proliferation and invasion-related genes were detected.Results:6 h,12 h,18 h and 24 h after treatment,the number of apoptotic cells of 5-Fu group and SB+5-Fu group was significantly more than that of NC group,the number of invasive cells was significantly less than that of NC group,the number of apoptotic cells of SB+5-Fu group was significantly more than that of 5-Fu group,and the number of invasive cells was significantly less than that of 5-Fu group;mRNA contents of Vav3

  16. Juízo e ação moral: desafios teóricos em psicologia Judgment and moral action: theoretic challenges in psychology

    Directory of Open Access Journals (Sweden)

    Leonardo Lemos de Souza

    2009-12-01

    Full Text Available O presente artigo apresenta e discute a polêmica, no campo da psicologia moral, sobre as relações entre juízo e ação. Teorias de tradição racionalista e estruturalista, como as de Piaget e Kohlberg, afirmam uma relação de continuidade entre juízo e ação moral e, ao mesmo tempo, lançam pontos de discussão sobre a complexidade envolvida no tema. Por outro lado, novas frentes de trabalho sugerem a integração de outros elementos (a cultura, a afetividade e o self, além das estruturas que podem compor um referencial com o qual se evidenciem as relações entre os aspectos envolvidos nas condutas morais. Por fim, apesar das críticas acenarem com caminhos promissores na pesquisa sobre o juízo e a ação moral, ainda existem limites na construção de referenciais teóricos e metodológicos que articulem diferentes perspectivas de análise psicológica da moralidade.The attending article presents and discusses the debate within the cognitive constructivist theories, which have as main representatives Jean Piaget and Lawrence Kohlberg. Such theories of rationalist and structuralist tradition maintain continuity between judgment and moral action and, at the same time, launch points of discussion on the complexity involved in the theme. New work fronts suggest the integration of other elements: culture, affectionateness, and the self, beyond the structures that may compound a referential that explains the relations between the aspects involved in moral behavior. Lastly, despite the criticism indicating a promising path in the search about judgment and moral action, considering its complex character, there are still limits in the making of the theoretical and methodological frameworks that articulate different perspectives of moral psychological analyses.

  17. A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment

    Directory of Open Access Journals (Sweden)

    Chen Yan-Chu

    2011-05-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the predominant gastrointestinal malignancy and the leading cause of cancer death. The identification of genes related to CRC is important for the development of successful therapies and earlier diagnosis. Methods Molecular analysis of feces was evaluated as a potential method for CRC detection. Expression of a predicted protein with unknown function, KIAA0247, was found in feces evaluated using specific quantitative real-time polymerase chain reaction. Its cellular function was then analyzed using immunofluorescent staining and the changes in the cell cycle in response to 5-fluorouracil (5-FU were assessed. Results Gastrointestinal tissues and peripheral blood lymphocytes ubiquitously expressed KIAA0247. 56 CRC patients fell into two group categories according to fecal KIAA0247 mRNA expression levels. The group with higher fecal KIAA0247 (n = 22; ≥ 0.4897 had a significantly greater five-year overall survival rate than the group with lower fecal KIAA0247 (n = 30; p = 0.035, log-rank test. Fecal expression of KIAA0247 inversely related to CRC tumor size (Kendall's tau-b = -0.202; p = 0.047. Immunofluorescent staining revealed that the cytoplasm of CRC cells evenly expresses KIAA0247 without 5-FU treatment, and KIAA0247 accumulates in the nucleus after 40 μM 5-FU treatment. In HCT116 p53-/- cells, which lack p53 cell cycle control, the proportion of cells in the G2/M phase was larger (13% in KIAA0247-silent cells than in the respective shLuc control (10% and KIAA0247-overexpressing cells (7% after the addition of low dose (40 μM 5-FU. Expression of three cyclin genes (cyclin A2, cyclin B1, and cyclin B2 also downregulated in the cells overexpressing KIAA0247. Conclusions This is the first description of a linkage between KIAA0247 and CRC. The study's data demonstrate overexpression of KIAA0247 associates with 5-FU therapeutic benefits, and also identify the clinical significance of fecal KIAA0247

  18. rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment.

    Science.gov (United States)

    Russo, Annapina; Saide, Assunta; Cagliani, Roberta; Cantile, Monica; Botti, Gerardo; Russo, Giulia

    2016-12-07

    5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application. In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels. rpL3 also regulates negatively the activation of NFκB by preventing NFκB nuclear translocation through IκB-α up-regulation. Furthermore, we demonstrate that rpL3 significantly enhances the apoptosis of 5-FU treated Calu-6 cells promoting the overexpression of the pro-apoptotic proteins Bax and the inhibition of the anti-apoptotic protein Bcl-2. We finally demonstrate that rpL3 potentiates 5-FU efficacy inhibiting cell migration and invasion. Our results suggest that combination of rpL3 and 5-FU is a promising strategy for chemotherapy of lung cancers lacking functional p53 that are resistant to 5-FU.

  19. Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution.

    Science.gov (United States)

    Glavas-Dodov, Marija; Steffansen, Bente; Crcarevska, Maja S; Geskovski, Nikola; Dimchevska, Simona; Kuzmanovska, Sonja; Goracinova, Katerina

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these carriers for efficient treatment of colon cancer by studying in vitro permeability and cell association of 5-FU and [methyl-³H]thymidine uptake in Caco-2 cells, as well as in vivo gastrointestinal distribution. The amount of 5-FU permeated through Caco-2 cells was 15.1, 7.7 and 6.5% for 5-FU solution, CTS-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region.

  20. Wheat germ allutinin functionalized crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: In vitro efficacy and in vivo gastrointestinal distribution

    DEFF Research Database (Denmark)

    Glavas-Dodov, Marija; Steffansen, Bente; Crcarevska, Maja

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential...... of these carriers for efficient treatment of colon cancer by studying in vitro permeability and cell association of 5-FU and [methyl-³H]thymidine uptake in Caco-2 cells, as well as in vivo gastrointestinal distribution. The amount of 5-FU permeated through Caco-2 cells was 15.1, 7.7 and 6.5% for 5-FU solution, CTS......-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed...

  1. Spectral energy distribution analysis of class I and class II FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Gramajo, Luciana V.; Gómez, Mercedes [Observatorio Astronómico, Universidad Nacional de Córdoba, Argentina, Laprida 854, 5000 Córdoba (Argentina); Rodón, Javier A., E-mail: luciana@oac.uncor.edu, E-mail: mercedes@oac.uncor.edu, E-mail: jrodon@eso.org [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago 19 (Chile)

    2014-06-01

    FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

  2. 藤黄酸合用氟尿嘧啶抗肿瘤活性的研究%Anti-tumor Activity of Gambogic Acid Combined with 5-Fu

    Institute of Scientific and Technical Information of China (English)

    骞秀芳; 郭喆; 史小四; 刘丹

    2013-01-01

    目的:探讨藤黄酸(GA)与氟尿嘧啶(5-Fu)联合应用的抗肿瘤活性.方法:MTT法观察GA合用5-Fu对刀豆蛋白A诱导的小鼠脾细胞增殖的影响;小鼠接种S180肉瘤,分为模型组、GA组(20 mg·kg-1)、5-Fu组(20 mg·kg-1)、GA合用5-Fu组(GA 20 mg · kg-1 + 5-Fu 20 mg·kg-1),每组10只,腹腔注射给药10 d后,各组称体质量,取瘤体、脾脏和胸腺称质量,计算抑瘤率、脾指数、胸腺指数.结果:GA合用5-Fu对淋巴细胞增殖表现出较强的抑制活性(P<0.01),抑制作用随药物浓度的增加而提高.GA合用5-Fu组的瘤质量与模型组、GA组、5-Fu组相比明显降低(P<0.01),抑瘤率达62.4%,明显大于单用GA或5-Fu.与5-Fu组相比,GA合用5-Fu可明显提高脾指数和胸腺指数(P<0.05).结论:GA合用5-Fu具备良好的体内外抗肿瘤活性,有协同作用.%Objective:To investigate the anti-tumor activity of gambogic acid (GA) combined with 5-fluorouracil (5-Fu).Method:The effect of GA plus 5-Fu on the mouse spleen lymphocyte proliferation in vitro was determined by an MTT assay.The mice were transplanted tumor S180,then divided into 4 groups randomly:GA group (20 mg · kg-1),5-Fu group (20 mg · kg-1),GA plus 5-Fu group (20 mg· kg-1 +20 mg · kg-1) and the model group(n =10).All mice were with intraperitoneal injection for ten days.After body-weighting,the effect of GA plus 5-Fu on tumor growth,spleen index and thymus index was determined.Result:GA plus 5-Fu significantly inhibited the proliferation of lymphocytes induced by ConA in a dose-dependent manner(P <0.01).The tumor growth in GA plus 5-Fu group was notablyinhibited compared with that in the model group (P < 0.01).The S180 inhibition rate in GA plus 5-Fu group reached 62.4%,which was higher than that in GA and 5-Fu group.In addition,GA plus 5-Fu had a protective effect on immune suppression caused by 5-Fu.Conclusion:GA plus 5-Fu can inhibit tumor growth effectively with a synergism.

  3. Diversidad del género Amanita en dos áreas con diferente condición silvícola en Ixtlán de Juárez, Oaxaca, México Diversity of the genus Amanita in two areas with different forestry management in Ixtlán de Juárez, Oaxaca, Mexico

    OpenAIRE

    Emmanuel Villanueva-Jiménez; Margarita Villegas-Ríos; Joaquín Cifuentes-Blanco; Hugo León-Avendaño

    2006-01-01

    Se estudió la diversidad de especies de Amanita presentes en dos áreas de bosque de Pinus-Quercus con diferente manejo silvícola en la comunidad de Ixtlán de Juárez, Oaxaca. Las recolectas se realizaron durante una temporada de lluvias, obteniéndose un total de 107 ejemplares que corresponden a 36 especies, de las cuales 21 pertenecen al subgénero Amanita y 15 al subgénero Lepidella; 14 nuevos registros son para el estado de Oaxaca y 19 para la comunidad de Ixtlán en particular. La abundancia...

  4. Lokalne skupnosti in skupnostna skrb na področju duševnega zdravja: perspektiva upravnih subjektov, izvajalcev in uporabnikov

    Directory of Open Access Journals (Sweden)

    Vesna Zupančič

    2014-12-01

    Full Text Available članek osvetljuje vlogo lokalne skupnosti pri razvoju skupnostne skrbi na področju duševnega zdravja, kot jo vidijo tri skupine deležnikov: občinski uslužbenci (uslužbenci lokalnih skupnosti/upravnih subjektov, izvajalci v mreži programov in storitev za duševno zdravje ter uporabniki teh storitev. Gre za presečno študijo primera zdravstvene regije Novo mesto s kombinacijo kvantitativnih in kvalitativnih metod, s cilji oceniti sedanje stanje skrbi in ugotoviti, ali obstajajo razlike v razumevanju vloge lokalnih skupnosti pri razvoju skupnostne skrbi za duševno zdravje. Ugotovitve raziskave nakazujejo nekatere priložnosti za izboljšanje procesov skupnostne skrbi.

  5. Subjetividades disidentes y el (desdominio del biopoder paralegal: la producción sociocultural de los cuerpos en Ciudad Juárez, México

    Directory of Open Access Journals (Sweden)

    Salvador Salazar Gutiérrez

    2014-01-01

    Full Text Available En el escenario de violencia en el contexto de Ciudad Juárez, se viene articulan - do la tensión entre el proyecto dominante de un biopoder paralegal caracterizado por tres factores: la presencia del narcotrá¿co, la nulidad biográ¿ca de todo aquel cargado con el estigma de amenazante, así como la precarización estructural y vital de la mayoría de los habitantes de esta ciudad fronteriza. Frente a ello, se encuentra el surgimiento incipiente de una biorresistencia caracterizada por la práctica disidente de colectivos juveniles, que a partir de diversas estrategias buscan construir un proyecto alterno de reconocimiento.

  6. Between fear and differentiation. The current situation of gated communities within border towns such as Tijuana, Nogales and Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Jesús Ángel Enríquez Acosta

    2007-01-01

    Full Text Available In the cities of Tijuana, Nogales and Ciudad Juárez, located in the northwestern border between Mexico and the United States, one of the more popular urbanization processes is the modality of closed divisions. These residential areas are characterized for being a physical space protected and separated from the city disturbances with bars and fences, and most of them present monitoring houses with access restrictions and private surveillance. The concept of closed divisions tends to expand in the urban landscape of the border cities without restrictions except for those established by the real estate market. Nevertheless, it's important to analyze the impact of closed divisions in the morphology of the cities, the urban sustentability of this developments and the social segregation they cause.

  7. La minería como factor de desarrollo en la Sierra Juárez de Oaxaca. Una valoración ética

    Directory of Open Access Journals (Sweden)

    Mario Enrique Fuente

    2013-01-01

    Full Text Available El gobierno mexicano ha justificado el otorgamiento de concesiones mineras en territorios indígenas como estrategia para promover el desarrollo. Esta acción –desplegada desde los postulados de la teoría del equilibrio general competitivo– evade incorporar los costos e implicaciones éticas y ambientales. Frente a estas limitantes, el artículo explora campos analíticos heterodoxos y una praxis concreta: la comunitaria de origen zapoteca de Capulálpam, en la Sierra de Juárez de Oaxaca, México, frente al proceso de otorgamiento de concesiones mineras en su territorio. Esta indagatoria pretende dimensionar territorial y políticamente el debate ético del desarrollo y la sustentabilidad.

  8. Activismo transnacional y calidad de la democracia en México: Reflexiones en torno al caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Alberto Martín

    2008-04-01

    Full Text Available Abstract: Transnational activism and quality of democracy  in Mexico: reflections centring on the case of Ciudad JuárezThis article analyses the impact of transnational  activism in the call to solve the deaths of hundreds of women in Cuidad Juárez. The efforts of  organizations of relatives of disappeared women  to secure the solidarity of national and international organizations and networks have been crucial  in influencing the federal Mexican government to  investigate these crimes. In addition, by placing  the problem inside wider frames of interpretation  – those of gender violence and human rights–, the  organizations of Juarez have helped to open the  debate concerning the question of violence in  general against women in Mexico. Nevertheless,  the results of the movement at the local level are  still far from satisfactory due to questions related  both to internal problems and weaknesses of local  organizations as well as to structural problems of  democracy in Mexico, which include the weakness of rule of law and the ineffectiveness of the  political system in implementing effective accountability.Resumen:El artículo analiza el impacto de la internacionalización de la movilización en pro del esclarecimiento de los crímenes cometidos contra mujeres  en Ciudad Juárez, México. La capacidad de las  organizaciones de familiares de desaparecidas de  concitar la solidaridad de organizaciones y redes  nacionales e internacionales, ha sido determinante  para desencadenar la intervención del gobierno  federal mexicano en la investigación de los crí- menes. Asimismo, a través de la inserción del  problema en marcos de interpretación más amplios – los de la violencia de género y los derechos humanos -, las organizaciones de Juárez han  contribuido a abrir el debate en torno a la violencia contra la mujer en México. Sin embargo, a  nivel local los resultados del movimiento se encuentran aún lejos

  9. Identidad cultural, actitudes políticas y valores socioculturales en Tijuana, Ciudad Juárez, Nuevo Laredo y San Luis Potosí

    Directory of Open Access Journals (Sweden)

    José Carlos Lozano Rendón

    1990-05-01

    Full Text Available Mediante el uso de la base de datos que constituye la Encuesta Socioeconómica Anual de la Frontera 1987 (ESAF 87 de El Colegio de la Frontera Norte, el presente artículo discute las actividades políticas hacia Estados Unidos y ciertos valores familiares tradicionales de México en los encuestados de Tijuana, Ciudad Juárez, Nuevo Laredo y San Luis Potosí.Mediante el análisis de las escalas de actitudes sobre el sistema capitalista, sobre los Estados Unidos y sobre las premisas socioculturales definidas por Rogelio Díaz Guerrero, como características de elementos de la cultura tradicional mexicana, se concluye que la clase social y el sexo constituyen variables más útiles para predecir la pérdida de identidad cultural que la proximidad geográfica con los Estados Unidos.

  10. Organización y promoción de las actividades artísticas en Ciudad Juárez, Chihuahua 1945-1990

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    César Fuentes Flores

    1993-01-01

    Full Text Available En este trabajo se analiza la manera en que se ha organizado la promoción, el consumo, así como el nivel de institucionalización de las actividades artísticas en Ciudad Juárez durante el periodo 1945-1990. Asimismo, se reconstruye cómo y cuáles agentes sociales participaban en la promoción de las actividades artísticas y culturales, cuál era el esquema de promoción que seguían dichos grupos en cuanto al tipo de especialidades artísticas que organizaban, así como cuáles fueron los espacios físicos utilizados para el desarrollo de este tipo de actividades. En general la información utilizada es hemerográfica, del mismo modo se realizaron entrevistas con informantes claves

  11. Convergencia tecnológica y nacimiento de las maquiladoras de tercera generación: el caso Delphi-Juárez

    OpenAIRE

    Arturo Lara Rivero

    2001-01-01

    El objetivo de este trabajo es el de explicar el nacimiento de un moderno, inédito centro de investigación y desarrollo de auto partes electrónicas: Delphi - Juárez . La pregunta básica que guía este trabajo es la siguiente: ¿cuáles son las implicaciones de la convergencia tecnológica electrónica / automotriz sobre el número, distribución espacial y jerárquica de los proveedores? Esta convergencia tecnológica viene a revalorizar las antiguas funciones eléctricas (y tanto a los viejos proveedo...

  12. Duelos: Sobre 'Hombre de la esquina rosada' e 'Historia de Rosendo Juárez', de Jorge Luis Borges y 'Gaucho pobre', de Enrique Amorim

    Directory of Open Access Journals (Sweden)

    Pablo Rocca

    2009-11-01

    Full Text Available El núcleo temático y aun la estructura del primer cuento de Borges, finalmente titulado 'Hombre de la esquina rosada', fueron retomados por el uruguayo Enrique Amorim en 'Gaucho pobre'. Cada historia está dedicada por cada escritor al otro. En primer lugar, este artículo trabaja sobre las posibilidades de diálogo formal entre los dos cuentos y, luego, aborda otros planos -privilegiando lo ideológico y el problema del realismo- en que los autores se encuentran y se distancian. Asimismo, se observan las repercusiones posibles que ese cruce pudo tener en 'Historia de Rosendo Juárez', el contrapunto de Borges a su historia originaria

  13. Iedzīvotāju viedoklis par teledarba attīstības iespējām Latvijā

    OpenAIRE

    Vītola, A; Judrupa, I; Baltiņa, I; Ādamsone, L

    2013-01-01

    Laika posmā no 2012.gada 27.jūnija līdz 2012.gada 21.oktobrim INTERREG IVC projekta „MICROPOL – attālinātie darba centri ārpus metropoļu reģioniem” ietvaros Rīgas Tehniskās universitātes Tautsaimniecības un reģionālas ekonomikas institūts, sadarbojoties ar Limbažu un Balvu pašvaldībām, īstenoja aptauju, lai noskaidrotu iedzīvotāju viedokli par attālinātā darba izmantošanas iespējām, it īpaši novērtējot šādas darba formas attīstības iespējas Limbažu un Balvu novados....

  14. Duelos: Sobre 'Hombre de la esquina rosada' e 'Historia de Rosendo Juárez', de Jorge Luis Borges y 'Gaucho pobre', de Enrique Amorim

    Directory of Open Access Journals (Sweden)

    Pablo Rocca

    2009-11-01

    Full Text Available El núcleo temático y aun la estructura del primer cuento de Borges, finalmente titulado 'Hombre de la esquina rosada', fueron retomados por el uruguayo Enrique Amorim en 'Gaucho pobre'. Cada historia está dedicada por cada escritor al otro. En primer lugar, este artículo trabaja sobre las posibilidades de diálogo formal entre los dos cuentos y, luego, aborda otros planos -privilegiando lo ideológico y el problema del realismo- en que los autores se encuentran y se distancian. Asimismo, se observan las repercusiones posibles que ese cruce pudo tener en 'Historia de Rosendo Juárez', el contrapunto de Borges a su historia originaria

  15. Condiciones de trabajo en la industria maquiladora de tipo electrónico. El caso de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Lilia Venegas Aguilera

    1985-01-01

    Full Text Available Este trabajo es un avance de la investigación emprendida en el año de 1981 realizada en torno a las condiciones de vida y de trabajo en la industria maquiladora. Para ello se eligió a Ciudad Juárez, que para 1982 contaba ya con 42,695 trabajadores en este tipo de industria. En primer lugar se presenta la importancia y características de esta industria, particularmente de tipo electrónico, y dentro de este marco referencial se aborda el análisis de las condiciones laborales de las trabajadoras de esta rama industrial que representaban el 67% del total de trabajadores de maquiladoras de esa ciudad fronteriza. La fuente de información proviene de una encuesta aplicada en 28 empresas, el 57% de las existentes y alrededor de 162 obreras.

  16. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Glimelius, B; Sørbye, H; Balteskard, L

    2008-01-01

    not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

  17. 唐末辞赋创作的转向与赋学思想论%Fu Writing in Late Tang Dynasty:Change and Ideology

    Institute of Scientific and Technical Information of China (English)

    孙福轩

    2013-01-01

    The late Tang dynasty is an important period in the history of Fu study when changes appear in Fu writing of each type .Content of comments and reasoning was merged into Sao style Fu besides the emotions . Rhythmical prose style Fu was also added with comment and reasoning , divorcing from the beauty and paralleling style in the early Tang dynasty .Symmetrical style Fu was not the content for imperial examination and used to chant the past and express the emotions , thus creating the verse Fu .In Fu ideology , ideas of valuing feelings and empha-sizing the past appear , while schools of euphuism and satire exist together .The view to Qu Yuan , Song Yu and Yang Xiong had changed to some extent .%唐末是中国赋学发展史上的一个较为重要的历史时期,各体辞赋创作纷纷出现转向,骚体赋在言情之外,融入议论说理的成分;骈体赋脱离了唐初以来的俪美和骈对习气,亦以议论、说理入赋;律体赋脱离科举,转向咏古和对情志的抒发,文体赋开始出现。在赋学思想上,表现出辞采派和讽谏派的交互,同时也有重情和重古的观点出现,对屈原、宋玉和扬雄的看法也有不同程度的转变。

  18. MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins.

    Science.gov (United States)

    Yin, Jie; Tang, Hui Fang; Xiang, Qiong; Yu, Jia; Yang, Xiao Yang; Hu, Nan; Lei, Xiao Yong

    2011-12-01

    To investigate the changes in drug sensitivity of miR-122 transfected BEL-7402/5-FU cells. MiR-122 and negative miRNA expression vectors were constructed and stably transfected into BEL-7402/5-FU cells. Real-time RT-PCR was used to detect the level of miR-122, Bcl-XL, Bcl-2 and P53 mRNA. Western Blotting was used to detect Bcl-2, Bcl-XL and P53 protein expression. Drug sensitivity of the cells to 5-fluorouracil (5-FU) was analyzed with MTT and flow cytometry. Compared with negative miRNA transfectants or untreated cells, mRNA and protein expression level of Bcl-2, Bcl-XL in stable miR-122 transfectants were decreased. Accordingly, P53 protein expression showed a significant up-regulation; MTT results showed that after incubation with 5-FU, miR-122 transfectants had higher cell inhibitory rates than negative miRNA or untreated cells; flow cytometry results demonstrated that apoptosis rate increased in miR-122 transfected cells, compared with negative miRNA or untreated cells. After addition of 5-FU (10 and 100 micromol/I), miR-122 transfected cells showed higher apoptosis rate than negative miRNA or untreated cells. MiR-122 can specifically down-regulate the expression of Bcl-2 and Bcl-XL, and increase P53 activity in BEL-7402/5-FU cells, which increased cells spontaneous apoptosis and sensitize cells to 5-FU. Therefore, MiR-122 can be used as a potential therapy agent against human hepatoblastoma.

  19. Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis.

    Science.gov (United States)

    Dun, Jiening; Chen, Xueyan; Gao, Haixia; Zhang, Yan; Zhang, Huajun; Zhang, Yongjian

    2015-12-01

    Many studies have shown that natural dietary agents, in combination with chemical agents, can improve the therapeutic response of cancers to chemotherapy and reduce the associated side-effects. In the present study, we investigated the therapeutic potential and mechanisms of anticancer effects for the combination of 5-fluorouracil (5-FU) and resveratrol (Res). In these studies, we employed the cancer cell lines TE-1 and A431 and an animal model of skin cancer. The presented results provide the first evidence that Res can enhance the anti-tumor potency of 5-FU by inducing S-phase arrest. The combination of Res and 5-FU demonstrates synergistic efficacy, causing tumor regression in a two-stage model of mouse skin carcinogenesis induced by DMBA and TPA. There was clear evidence of Res augmenting the growth inhibitory effect of 5-FU on the TE-1 and A431 cancer cells in vitro. In the in vivo studies, the tumor regression rate in the combination group increased significantly after four weeks of treatment (P 5-FU and Res significantly increased the percentage of apoptotic cells and the level of activated caspase-3, cleaved PARP and p53 proteins as well as increased the Bax/Bcl-2 ratio. In conclusion, the 5-FU/Res combination enabled a more effective inhibition of cell growth and the induction of apoptosis in cancer cells than 5-FU alone. The results of this study suggest that chemotherapy using natural dietary agents with chemical agents represents a superior cancer treatment option.

  20. Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia.

    Science.gov (United States)

    Wang, Yu; Miao, Jin-Wei; Wang, Tong; Wang, Yan; Wu, Yu-Mei; Kong, Wei-Min; Su, Li; Duan, Wei

    2016-04-01

    The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN). Clinical data from 66 LR-GTN patients, admitted to the Beijing Obstetrics and Gynecology Hospital from January 2010 to April 2012, were analysed retrospectively. In total, 32 patients were treated with a MACT therapeutic regimen and the remaining 34 with a 5Fu + ACT-D therapeutic regimen. Complete remission rates (CR), duration of treatment, hospital stay and toxicity effects were compared. There was no statistical difference in CR for the MACT (90.63%) or the 5-Fu plus ACT-D (100%) therapeutic regimens (p = 0.0676) or in the duration of treatment [MACT (3.50) or 5-Fu plus ACT-D (3.71; p = 0.2021)]. Moreover, the hospital stay in the 5-Fu plus ACT-D group (32.88 days) was significantly longer than for the MACT group (22.09 days; p < 0.001). Furthermore, the degree of myelosuppression, nausea and vomiting, diarrhoea, stomatitis and alopecia was more severe in the 5Fu + ACT-D group (p < 0.01). However, there was no statistical difference in the severity of liver function damage between the two groups. A shorter hospital stay, lower hospitalization cost and slightly more toxic effects were observed in LR-GTN patients treated with the MACT therapeutic regimen. We suggest that the MACT regimen should be used as first-line chemotherapy for LR-GTN.

  1. 浅析班固赋学观的矛盾%ANALYSIS ON THE CONTRADITIONS OF BAN GU'S VIEW ON HAN FU STUDY

    Institute of Scientific and Technical Information of China (English)

    余江; 刘雪妮

    2012-01-01

    As a literature genre of the Han Dynasty, Han Fu was born in contradictive and awkward situations. The Han Fu-writers are further plagued with contradictions and suffering. Ban Gu is one of the greatest Four Han Fu-writers in the Hart Dynasty. His view on Hart Fu study is distinctive and unique. The connotation and reasons implied in his Hart Fu verse are profound. His contradictive Confucius-poetic-based view on Han Fu, the divergence between his self-contradictive art criticism and theory and his literature production are the specific embodiment of his understanding of Fu--a special literature genre. Ban Gu's contradiction is mainly caused by the complexity of his social status identity and Scholars' special living condition and state of mind.%汉赋作为有汉一代之文学,从产生之初就伴随和背负上了重重矛盾和尴尬,赋家本身更是充满了矛盾和煎熬。斑回作为“汉赋四大家”之一.其围绕赋表现出的矛盾有其深刻的内涵和原因.他的赋学观鲜明而独特。他基于儒家诗学观的矛盾赋学观、自相矛盾的赋体艺术批评以及理论与创作的自我割裂与背叛是他对赋这种特殊文体的认识矛盾重重的具体表现。班固的矛盾主要缘于其身份的复杂性和当时士人特殊的生存状态与心态。

  2. 白花蛇舌草注射液逆转人肝癌细胞BEL-7402/5-FU 的多药耐药作用%Effect of Hedyotic diffusa injection in reversing multi-drug resistance of human hepatoma BEL-7402/5-FU cells

    Institute of Scientific and Technical Information of China (English)

    廖作庄; 韦丽美; 徐灵源; 梁钢

    2015-01-01

    Objective To study the effect and mechanism of Hedyotic diffusa injection in reversing multi-drug resistance of BEL-7402/5-FU cells.Methods The IC50 of BEL-7402/5-FU cells was examined by MTT,apoptosis was detected by flow cytometry,and the content of tyrosine kinase in total protein of tumor cells was detected by enzyme-linked immunosorbent assay (ELISA).Results The IC50 of Hedyotic diffusa injection (6 μL/mL ) combined with 5-FU (636.5 μmol/L)decreased significantly compared with that of 5-FU applied alone (1 071.6 6μmol/L). The reversal on BEL-7402/5-FU was 1.68-fold.After injection of 5-FU plus Hedyotic diffusa ,the apoptosis rate of BEL-7402/5-FU cells was increased significantly and the tyrosine kinases of BEL-7402/5-FU cells decreased significantly.Conclusion Hedyotic diffusa injection plays a certain role in reversing multi-drug resistance of BEL-7402/5-FU cells,which may be related to decreasing their tyrosine kinases.%目的:研究白花蛇舌草注射液对 BEL-7402/5-FU 细胞多药耐药的逆转作用,并探讨其作用机制。方法四甲基偶氮唑蓝(MTT)法检测药物对 BEL7402/5-FU 细胞的半数抑制浓度(IC50);流式细胞仪检测细胞凋亡;ELISA 双抗体一步夹心法测定酪氨酸激酶含量。结果无毒剂量的白花蛇舌草注射液(6μL/mL)联合5-FU 对 BEL-7402/5-FU细胞的 IC50为636.5μmol/L,比单独应用5-FU 的 IC50(1071.6μmol/L)明显下降,逆转倍数为1.68;加白花蛇舌草注射液后,5-FU 对 BEL-7402/5-FU 细胞的凋亡比例明显增加,且显著下调 BEL-7402/5-FU 细胞的酪氨酸激酶含量。结论白花蛇舌草注射液对 BEL-7402/5-FU 细胞的多药耐药性具有一定的逆转作用,其机制可能与下调酪氨酸激酶有关。

  3. The coronary dilation effect of shen fu injection was mediated through NO.

    Directory of Open Access Journals (Sweden)

    Yu Hong Li

    Full Text Available OBJECTIVES: Shen Fu Injection (SF, which consisted of Red ginseng extraction injection (RG and prepared aconite extraction injection (RA, is a traditional Chinese medicine mainly used for various cardiac diseases. This study is to analyse SF's effects on cardiac performance and coronary circulation. And the coronary dilating effect and mechanism of the above three injections were also explored. METHODS: Mature male guinea pigs were used as our animal model. We employed two types of perfusion methods (constant pressure and constant flow in vitro, using Langendorff heart preparations to observe the cardiac function and coronary response to SF (1/200. The coronary dilation effects of the above three injections (1/800, 1/400 and 1/200 were recorded at basal coronary resting tone and when coronary vessels were pre-contracted with a thromboxane A2 analogue (U46619, in the presence or the absence of the inhibitor of nitric oxide synthesis (L-NAME, 10-4 M, the blocker of Ca2+-activated potassium channel(TEA, 10-3 M, or the blocker of adenosine triphosphate (ATP-sensitive potassium channel (glybenclamide (10-5 M. RESULTS: When perfused with constant pressure, SF significantly increased coronary flow, left ventricular developed pressure (LVDP and the rate-pressure product (RPP. When perfused with constant flow, SF produced a significant reduction in the coronary perfusion pressure (CPP, LVDP and RPP. The coronary vasodilatation response of the above three injections can be reduced by L-NAME but was unaffected by TEA or glybenclamide when coronary vessels were pre-contracted with U46619 but not at resting tone. SF, RG and RA can all up-regulate eNOS expression in the human umbilical vein cells (EA.hy926. CONCLUSION: We demonstrated that SF does not contribute to the inotropic change of myocardium whose improvement is due to alternation of coronary flow. The coronary dilation effect of SF was mediated through RG and RA, via promoting NO release.

  4. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

    Directory of Open Access Journals (Sweden)

    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  5. Electromyographic Study of a Sequence of Yau-Man Kung Fu Palm Strikes with and without Impact.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Pacheco, Marcos T T

    2007-01-01

    IN MARTIAL ARTS AND CONTACT SPORTS, STRIKES ARE OFTEN TRAINED IN TWO DIFFERENT WAYS: with and without impacts. This study aims to compare the electromyographical activity (EMG) of the triceps brachii (TB), biceps brachii (BB) and brachioradialis (BR) muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms) and frequency (wavelet) domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar. Key pointsEMG analysis of a sequence of Kung Fu strikes demonstrates higher Triceps Brachii and Brachioradialis muscle activity for strikes with impact than strikes without impact.An original reliable method for quantifying EMG wavelet transform results is presented.EMG wavelet power spectra describe muscle roles during a Kung Fu sequence of strikes.

  6. On the Origination about the Theme of Wild Goose Fu%论雁赋主题渊源

    Institute of Scientific and Technical Information of China (English)

    赵金平

    2016-01-01

    雁在上古典籍中就被赋予丰富的文化意蕴,人们将雁的特征与习性和世俗的事物联系起来,或寓意祥瑞与纯贞,或象征礼仪与秩序,或譬喻懿德与壮志,或寄寓感慨,抒发生命体悟,雁赋主题渊源于此,后世传承上古典籍中的雁文化,既有因循又有变革。在分析雁赋文本的基础上,对雁赋主题进行类分,进而对其主题渊源进行分析。雁赋传承并丰富了民族文化,是中华民族智慧和情感的体现。%Wild geese were endowed with abundant cultural connotations in ancient texts.People related characteristics and habits of wild geese to world things,presenting auspicious sign and pure state,or symboli-zing etiquette and order,or analogizing with virtue and ambition,or reflecting their feelings and expressing the awareness of life,and so on.The theme of the wild goose originated from these good things,not only inherited the culture of wild goose in ancient classics,but also changed and reformed.Based on the analysis of wild goose culture,the paper classifies the themes of wild goose Fu and then discusses the origination about themes of wild goose Fu.Wild goose Fu inherited and enriched our ethnic culture,and presented the wisdoms and feelings of Chinese nationality.

  7. A novel comprehensive set of fungal Real time PCR assays (fuPCR) for the detection of fungi in immunocompromised haematological patients-A pilot study.

    Science.gov (United States)

    Rahn, Sebastian; Schuck, Anna; Kondakci, Mustafa; Haas, Rainer; Neuhausen, Nicole; Pfeffer, Klaus; Henrich, Birgit

    2016-12-01

    Fungal infections are recognized in an increasing number of patients with immunological deficits and are associated with high rates of mortality (Brown et al., 2012a). In this pilot-study, a rapid Real time PCR (fuPCR) was designed for the detection and differentiation of fungal pathogens in clinical specimens of haematological patients. The fuPCR, targeting the internal transcribed spacer region 2 (ITS2) of rDNA region, is comprised of seven multiplex reactions, which were shown to be specific and sensitive for a comprehensive spectrum of clinically relevant fungal species. This was validated by testing respective fungal DNAs in each fuPCR reaction and 28 respiratory samples of fungal pneumonia-proven patients. Clinical sample sets of throat swab, EDTA-blood and blood sera from 50 patients with severe haematological malignancies, including haematopoietic stem cell transfer (HSCT), and samples from 30 healthy individuals were then analysed. In a first step, 198 samples of immunosuppressed patients were solely examined by fuPCR; and 50.8% (33/65) respiratory swabs, 4.8% (3/63) EDTA blood samples and 1.4% (1/70) blood serum samples were tested positive. In a second step, 56 respiratory samples of immunosuppressed patients and 30 of healthy individuals were simultaneously analysed by fuPCR and standard cultivation techniques. By both methods 30.4% (17/56) swabs of the immunocompromised patients were tested positive, 37.5% (21/56) were tested negative and 32.1% (18/56) were tested fuPCR positive and culture negative. In analysing the blood samples of the immunocompromised patients 5.4% (3/56) EDTA blood samples and 16.1% (9/56) sera samples were tested fuPCR-positive, whereas all samples of 30 healthy individuals with no signs of immunological deficits were tested negative by fuPCR. 38.9% (14/36) of the fungi detected in respiratory samples of the immunosuppressed patients, belonged to Candida spp., 47.2% (17/36) to Saccharomyces spp., 5.6% (2/36) to Cladosporium spp

  8. HSP27在调控人胃癌细胞系5-FU 耐药中的作用机制%The Mechanism of HSP27 Regulation of 5-FU Resistant in Human Gastric Cancer Cell Lines

    Institute of Scientific and Technical Information of China (English)

    宋荣峰; 张慧卿; 熊彦; 王艳华; 万以叶

    2015-01-01

    目的:探讨热休克蛋白27(HSP27)在调控人胃癌细胞系5-FU耐药中的作用机制。方法培养人胃癌细胞株HGC27、BGC823、SGC7901、MKN28,采用CCK法筛选5-FU敏感株和耐药株,采用流式细胞仪和western blot 检测4株胃癌细胞株中HSP27表达水平,转染HSP27-siRNA,观察siRNA干扰后5-FU敏感株和耐药株中HSP27蛋白表达,并将两细胞株分别与不同浓度5-Fu共培养,采用CCK法检测细胞的半数抑制浓度( IC50)。结果 CCK法显示SGC7901细胞系是4株胃癌细胞中5-Fu相对耐药株,而HCG27是5-Fu相对敏感株。流式细胞仪显示SGC7901细胞株中HSP27表达水平最高为(72.10±1.89)%,而在HGC27细胞株中的表达水平最低为(22.12±1.33)%,各株表达水平比较差异有统计学意义( P<0.05)。转染HSP27-siRNA 后,各两株细胞HSP27蛋白表达水平均下降明显。与5-Fu共培养后, SGC7901细胞株转染组细胞半数抑制浓度降低,药物敏感性增强,与未转染组比较差异有统计学意义( P<0.05)。结论HSP27参与了SGC79015-FU耐药株中的细胞耐药,是诱导细胞多药耐药的重要分子机制,可以作为临床治疗靶点来提高胃癌患者对化疗的敏感性。%Objective To investigate the mechanism of HSP 27 of 5-FU resistant in human gastric cancer cell lines . Methods Human gastric cancer cell lines(HGC27,BGC823,SGC7901,MKN28)were cultured,and the cells which were resist-ant to 5-FU were selected by CCK assay and flow cytometry .The expression of HSP27 in these cells were detected by Western Blotting.And 2 cell lines were co-cultured with different concentration of 5-Fu,then the half inhibition concentration was detected by CCK assay.Results CCK assay showed that SGC7901 cell line was relatively resistant to 5-Fu,and the HCG27 cell line was relatively sensitive to 5-Fu.The flow cytometry results suggested that the expression of HSP 27 in the SGC7901 cells was

  9. [Preliminary clinical evaluation of low-dose cisplatin and continuous infusion of 5-FU (LFP) chemotherapy after weekly high-dose 5-FU therapy for the treatment of liver metastases from colorectal cancer].

    Science.gov (United States)

    Itoh, Satoshi; Morita, Sojiro; Ohnishi, Takenao; Tsuji, Akihito; Takamatsu, Masahiro; Horimi, Tadashi

    2002-07-01

    In this study, we evaluate the efficacy of low-dose cisplatin and continuous 5-FU infusion systemic chemotherapy (LFP therapy) for the treatment of unresectable and recurrent liver metastases from colorectal cancer after weekly high-dose 5-FU therapy via the hepatic artery (WHF therapy). At the start of chemotherapy, 12 patients with multiple extrahepatic lesions were treated with the LFP therapy (LFP group), and 18 patients with none or a few extrahepatic lesions were treated with the WHF therapy followed by the LFP therapy (LFP after WHF group). In the LFP group, the response rate was 50.0% (PR 6) and the one-year survival rate was 50.0%. On the contrary, in the LFP after WHF group, the response rate was 38.9% (CR 1, PR 6) and the one-year survival rate after LFP started was 46.0%. We conclude that the LFP therapy may be effective for the treatment of liver metastases from colorectal cancer even after the WHF therapy.

  10. 论南宋诗人使用杜诗典故的特点%Characteristics of Poets" Using Allusions from Du Fu's Poems In Southern Song Dynasty

    Institute of Scientific and Technical Information of China (English)

    左汉林

    2012-01-01

    Under the background of modeling and learning from Du Fu in the Song Dynasty, poets like to cite allusions from Du Fu's poems in the South Song Dynasty. Poets in the early Southern Song Period widely use Du's allusions and Lu You is the poet who cites allusions most from Du's poems in the two Song Dynasties. Poets in the late Southern Song Period cite fewer allusions from Du Fu's poems. Poets" using allusions from Du Fu's poems reflect the atmosphere of modeling and learning from Du Fu in the poetic world of Song Dynasties.%在宋代崇杜、学杜的背景下,南宋诗人作诗喜用杜诗典故。南宋前期诗人普遍使用杜诗典故较多,陆游是两宋使用杜诗典故最多的诗人。南宋末年诗人使用杜诗典故较少。南宋对杜诗典故的使用,反映出宋代诗坛的崇杜、学杜风气。

  11. HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.

    Science.gov (United States)

    Nagaraju, Ganji Purnachandra; Alese, Olatunji B; Landry, Jerome; Diaz, Roberto; El-Rayes, Bassel F

    2014-10-30

    Cell cycle progression and DNA synthesis are essential steps in cancer cell growth. Thymidylate synthase (TS) is a therapeutic target for 5FU. We tested the hypothesis that HSP90 transcriptional and functional inhibition can inhibit cell cycle progression, downregulate TS levels and sensitize colorectal cancer (CRC) cell lines to the effects of 5FU. Treatment with ganetespib (50 nM) for 24 hours inhibited cyclin D1 and pRb at the transcriptional and translational levels and induced p21, leading to G0/G1 cell cycle arrest in both CRC cell lines (HCT-116 and HT-29). This was associated with downregulation of E2F1 and its target gene TS. In addition, ganetespib inhibited PI3K/Akt and ERK signalling pathways. Similar effects were observed with HSP90 knockdown in both cell lines. Ganetespib sensitized CRC cell lines to the effects of oxaliplatin and 5FU. Similar effects were also observed in tumors from animals treated with ganetespib, oxaliplatin and 5FU. In this study, we present in vitro and animal data supporting that the targeting of HSP90 decreases CRC cell survival and proliferation. Ganetespib sensitizes CRC cell lines to the effects of 5FU-based chemotherapy. Combining HSP90 inhibitors with chemotherapy is a rational approach for future drug development in CRC.

  12. Effects of traditional Chinese medicine Fu Zheng decoction on the immunological function and clinical prognosis of the elderly patients with pneumonia.

    Science.gov (United States)

    Li, Hongqiang; Xu, Shumin; Cheng, Tingting; Tang, Lunxian; Bai, Jianwen; Lin, Minjia

    2015-01-01

    Pneumonia is one of the most serious infectious diseases for elderly people who have impaired organ functions and are more susceptible to infection. Elderly patients having pneumonia often need long-term hospitalization, leading to declined quality of life, and increase of financial burden to the society and their family. Therefore, studies on novel therapeutic strategies and the clinical prognosis of the pneumonia patients are imperative. In the present study, we found that the Chinese herbal medicine Fu Zheng decoction had great immunomodulatory effects during the recovery period of elderly pneumonia patients. Patients treated with combined treatment of Fu Zheng decoction and antibiotic had a faster decline of temperature and a more significant decrease of C reactive protein and inflammatory factors level, and it is easier for them to cough off phlegm, compared with the antibiotic only treatment. Furthermore, the inflammation absorption and the reduction of NK-cell proportion as well as the inflammatory factors were more remarkable in the patients taken Fu Zheng decoction. Especially, the Fu Zheng decoction treatment could decrease the duration of antibiotic treatment, which may help reduce the side effects of antibiotics. Our study also found that MyD88 might play a role in the immunomodulatory effect of Fu Zheng decoction. Our study provides novel insight for the further development of intravenous injection of Chinese materia medica preparation on the regulation of immune function.

  13. 杜诗数词的多重意义%Multiple meanings of the numerals in DU Fu's poems

    Institute of Scientific and Technical Information of China (English)

    魏耕原

    2015-01-01

    There are multiple meanings in the numerals of DU Fu's poems:firstly, the total number of poem groups shows the universality and particularity of number;secondly , special attention was paid to the digital reign title which is full of his poems;thirdly , he used lots of numerals in his poetry to record An-Shi Rebellion and the truth of history afterwards .These figures are full of feelings and desires as well as the aspirations for the future .The reality and the poetization of these figures constitute the special landscape of Du Fu's poems and reflect his broad and deep style .%杜诗里的数词具有多重意义:组诗的篇数呈现了数字的广泛性与特殊性;对表示数字式的年号特别重视,大量出现在诗中;他的诗史用了大量的数字,记录了安史之乱及其以后历史的真实。这些数字充满了感情与愿望,也充满了对未来的渴望;这些数字的真实与诗化,构成了杜诗一道又一道特殊的景观,也体现杜诗广博深沉的风格。

  14. TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Suresh Volate

    2009-01-01

    Full Text Available Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer cells lines. TJ-41 inhibited the proliferation of human breast cancer cell lines dose dependently. Flow cytometric analysis showed that this decrease in DNA synthesis is to be associated with induction of apoptosis. In both cell lines, apoptosis was abolished by caspase-9 inhibitor Z-LEHD-fmk but was weakly inhibited by caspase-8 inhibitor Z-IETD-fmk, indicating that caspase-9 activation was involved in TJ-41 induced apoptosis. Additionally, TJ-41 stimulated phosphorylation of c-Jun NH2-terminal kinase (JNK and pretreatment of breast cancer cells with JNK inhibitor SP600125 completely abolished TJ-41 induced apoptosis. Our data also demonstrate that combined treatment of TJ-41 and 5-FU significantly potentiates the apoptotic effects of 5-FU in both breast cancer cell lines. Taken together, these data suggest that TJ-41 might provide a novel chemotherapeutic treatment for breast cancer.

  15. A Simple Calculation in Service of Constraining the Rate of FU Orionis Outburst Events from Photometric Monitoring Surveys

    CERN Document Server

    Hillenbrand, Lynne A

    2015-01-01

    An enigmatic and rare type of young stellar object is the FU Orionis class. The members are interpreted as "outbursting," that is, currently in a state of enhanced accretion by several orders of magnitude relative to the more modest disk-to-star accretion rates measured in typical T Tauri stars. They are key to our understanding of the history of stellar mass assembly and pre-main sequence evolution, as well as critical to consider in the chemical and physical evolution of the circumstellar environment -- where planets form. A common supposition is that *all* T Tauri stars undergo repeated such outbursts, more frequently in their earlier evolutionary stages when the disks are more massive, so as to build up the requisite amount of stellar mass on the required time scale. However, the actual data supporting this traditional picture of episodically enhanced disk accretion are limited, and the observational properties of the known sample of FU Ori objects quite diverse. To improve our understanding of these rare...

  16. AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.

    Science.gov (United States)

    Wei, Xi; Duan, Wei; Li, Ying; Zhang, Sheng; Xin, Xiaojie; Sun, Lei; Gao, Ming; Li, Qing; Wang, Dong

    2016-06-01

    Gastric cancer remains a disease with a high mortality rate despite of multiple therapeutic strategies. So far, it is very important to develop new treatment approaches to improve current therapeutic efficacy in gastric cancer. Apurinic/apyrimidinic endonuclease (APE1) involves in DNA base excision repair (BER) during DNA damage pathway. APE1 was found to be associated with poor overall survival with gastric cancer patients. In the in vitro experiment, we tested APE1 inhibitor-AT101 could potently inhibit gastric cancer cell growth and further induce cancer cell apoptosis and autophagy through p53-dependent pathway. Downregulation of APE1 by AT101 has ability to suppress gastric cancer cell migration and renewal through inhibition of CD133, Nanog and LC3expression. Based on findings that Her-2 positive expression cases has poor prognosis from our dataset and TCGA database, we investigated the role of AT101 in synergetic efficacy with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell apoptosis. In summary, the data obtained from our study showed APE1 is guided as a potential therapeutic target for gastric cancer. AT101 could be regarded as a potent inhibitor to promote chemotherapeutic sensitivity in patients with gastric cancer.

  17. AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy

    Science.gov (United States)

    Wei, Xi; Duan, Wei; Li, Ying; Zhang, Sheng; Xin, Xiaojie; Sun, Lei; Gao, Ming; Li, Qing; Wang, Dong

    2016-01-01

    Gastric cancer remains a disease with a high mortality rate despite of multiple therapeutic strategies. So far, it is very important to develop new treatment approaches to improve current therapeutic efficacy in gastric cancer. Apurinic/apyrimidinic endonuclease (APE1) involves in DNA base excision repair (BER) during DNA damage pathway. APE1 was found to be associated with poor overall survival with gastric cancer patients. In the in vitro experiment, we tested APE1 inhibitor-AT101 could potently inhibit gastric cancer cell growth and further induce cancer cell apoptosis and autophagy through p53-dependent pathway. Downregulation of APE1 by AT101 has ability to suppress gastric cancer cell migration and renewal through inhibition of CD133, Nanog and LC3expression. Based on findings that Her-2 positive expression cases has poor prognosis from our dataset and TCGA database, we investigated the role of AT101 in synergetic efficacy with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell apoptosis. In summary, the data obtained from our study showed APE1 is guided as a potential therapeutic target for gastric cancer. AT101 could be regarded as a potent inhibitor to promote chemotherapeutic sensitivity in patients with gastric cancer. PMID:27144437

  18. The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias.

    Science.gov (United States)

    Falzacappa, Maria Vittoria Verga; Ronchini, Chiara; Faretta, Mario; Iacobucci, Ilaria; Di Rorà, Andrea Ghelli Luserna; Martinelli, Giovanni; Meyer, Lüder Hinrich; Debatin, Klaus-Michael; Orecchioni, Stefania; Bertolini, Francesco; Pelicci, Pier Giuseppe

    2015-04-01

    The existing treatments to cure acute leukemias seem to be nonspecific and suboptimal for most patients, drawing attention to the need of new therapeutic strategies. In the last decade the anticancer potential of poly ADP-ribose polymerase (PARP) inhibitors became apparent and now several PARP inhibitors are being developed to treat various malignancies. So far, the usage of PARP inhibitors has been mainly focused on the treatment of solid tumors and not too much about their efficacy on leukemias is known. In this study we test, for the first time on leukemic cells, a combined therapy that associates the conventional chemotherapeutic agent fluorouracil (5FU), used as a source of DNA damage, and a PARP inhibitor, rucaparib. We demonstrate the efficacy and the specificity of this combined therapy in killing both acute myeloid leukemia and acute lymphoid leukemia cells in vitro and in vivo. We clearly show that the inhibition of DNA repair induced by rucaparib is synthetic lethal with the DNA damage caused by 5FU in leukemic cells. Therefore, we propose a new therapeutic strategy able to enhance the cytotoxic effect of DNA-damaging agents in leukemia cells via inhibiting the repair of damaged DNA. ©2015 American Association for Cancer Research.

  19. Diversity of lactic acid bacteria in suan-tsai and fu-tsai, traditional fermented mustard products of Taiwan.

    Science.gov (United States)

    Chao, Shiou-Huei; Wu, Ruei-Jie; Watanabe, Koichi; Tsai, Ying-Chieh

    2009-11-15

    Fu-tsai and suan-tsai are spontaneously fermented mustard products traditionally prepared by the Hakka tribe of Taiwan. We chose 5 different processing stages of these products for analysis of the microbial community of lactic acid bacteria (LAB) by 16S rRNA gene sequencing. From 500 LAB isolates we identified 119 representative strains belonging to 5 genera and 18 species, including Enterococcus (1 species), Lactobacillus (11 species), Leuconostoc (3 species), Pediococcus (1 species), and Weissella (2 species). The LAB composition of mustard fermented for 3 days, known as the Mu sample, was the most diverse, with 11 different LAB species being isolated. We used sequence analysis of the 16S rRNA gene to identify the LAB strains and analysis of the dnaA, pheS, and rpoA genes to identify 13 LAB strains for which identification by 16S rRNA gene sequences was not possible. These 13 strains were found to belong to 5 validated known species: Lactobacillus farciminis, Leuconostoc mesenteroides, Leuconostoc pseudomesenteroides, Weissella cibaria, and Weissella paramesenteroides, and 5 possibly novel Lactobacillus species. These results revealed that there is a high level of diversity in LAB at the different stages of fermentation in the production of suan-tsai and fu-tsai.

  20. Acerca de “LEJOS DEL CORAZÓN”: Comentarios sobre el libro escrito por el Doctor Fernando Juárez Acosta.About "LEJOS DEL CORAZÓN": Comments about the book written by Dr. Fernando Acosta Juarez.

    OpenAIRE

    2014-01-01

    Acerca de “LEJOS DEL CORAZÓN”: Comentarios sobre el libro escrito por el Doctor Fernando Juárez Acosta. About "LEJOS DEL CORAZÓN": Comments about the book written by Dr. Fernando Acosta Juarez. Resumen   Una revisión detallada del libro titulado “Lejos del Corazón” escrito por el Doctor en Psicología Fernando Juárez Acosta, ha conducido a la elaboración de este artículo a través del cual se expone un análisis de algunos de los elementos que posibilitan el valor del texto en cuestión, en tanto...

  1. Relación entre consultas a urgencias por enfermedad respiratoria y contaminación atmosférica en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Hernández-Cadena Leticia

    2000-01-01

    Full Text Available OBJETIVO: Analizar la relación entre las concentraciones ambientales de partículas de diámetro <=10 µm (PM10 y de ozono con el número diario de consultas al servicio de urgencias por enfermedades respiratorias agudas y asma en niños menores de 15 años, residentes de Ciudad Juárez, Chihuahua, México. MATERIAL Y MÉTODOS: Este estudio se realizó durante los años de 1998 y 1999, utilizando un diseño de tipo ecológico. Los datos atmosféricos se obtuvieron de la base de datos de la Agencia de Protección al Ambiente (EPA, provenientes de ocho estaciones de monitoreo ubicadas en Ciudad Juárez y en El Paso, Texas. Los datos de consultas al servicio de urgencias por causas respiratorias se obtuvieron de los registros médicos de dos hospitales del Instituto Mexicano del Seguro Social (IMSS, en Ciudad Juárez, Chihuahua, de julio de 1997 a diciembre de 1998. Los diagnósticos se clasificaron en dos grupos: a asma, y b infecciones respiratorias altas, conforme a la Clasificación Internacional de Enfermedades (CIE-9 o CIE-10. El análisis se realizó con la utilización de la metodología de series de tiempo que emplea regresión Poisson. RESULTADOS: Durante el periodo de estudio la media de 24 horas de PM10 fue de 34.46 µg/m³ (DE=17.99 y la media de los niveles de ozono fue de 51.60 partes por billón (ppb (DE=20.70. El modelo propuesto estima que un incremento de 20 µg/m³ en el promedio de 24 horas, en la exposición a PM10, se relaciona con un incremento de 4.97% (IC 95% 0.97-9.13 en las consultas por asma con un retraso de cinco días y con un incremento de 9% (IC 95% 1.8-16.8 cuando se considera a la exposición acumulada de cinco días anteriores. Respecto a enfermedades respiratorias altas se encontró un aumento de 2.95% en las consultas a urgencias por cada 20 µm/m³ de incremento en el promedio de 24 horas en la exposición a PM10. Se observó que el impacto de PM10 sobre las visitas de urgencia por asma fue más severo en

  2. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD.

    Science.gov (United States)

    Cai, Donghui; He, Kang; Chang, Su'e; Tong, Dongdong; Huang, Chen

    2015-10-06

    MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.

  3. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

    Directory of Open Access Journals (Sweden)

    Donghui Cai

    2015-10-01

    Full Text Available MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.

  4. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment.

    Directory of Open Access Journals (Sweden)

    Kaja Lund

    Full Text Available Pancreatic adenocarcinoma is a lethal disease with 5-year survival of less than 5%. 5-fluorouracil (5-FU is a principal first-line therapy, but treatment only extends survival modestly and is seldom curative. Drug resistance and disease recurrence is typical and there is a pressing need to overcome this. To investigate acquired 5-FU resistance in pancreatic adenocarcinoma, we established chemoresistant monoclonal cell lines from the Panc 03.27 cell line by long-term exposure to increasing doses of 5-FU.5-FU-resistant cell lines exhibited increased expression of markers associated with multidrug resistance explaining their reduced sensitivity to 5-FU. In addition, 5-FU-resistant cell lines showed alterations typical for an epithelial-to-mesenchymal transition (EMT, including upregulation of mesenchymal markers and increased invasiveness. Microarray analysis revealed the L1CAM pathway as one of the most upregulated pathways in the chemoresistant clones, and a significant upregulation of L1CAM was seen on the RNA and protein level. In pancreatic cancer, expression of L1CAM is associated with a chemoresistant and migratory phenotype. Using esiRNA targeting L1CAM, or by blocking the extracellular part of L1CAM with antibodies, we show that the increased invasiveness observed in the chemoresistant cells functionally depends on L1CAM. Using esiRNA targeting β-catenin and/or Slug, we demonstrate that in the chemoresistant cell lines, L1CAM expression depends on Slug rather than β-catenin.Our findings establish Slug-induced L1CAM expression as a mediator of a chemoresistant and migratory phenotype in pancreatic adenocarcinoma cells.

  5. "Sensoro spēju attīstība nodarbībās bērniem vecumā no 2-3 gadiem, izmantojot Montesori metodiku"

    OpenAIRE

    Billerte, Anna

    2016-01-01

    Kvalifikācijas darba „Sensoro spēju attīstība nodarbībās bērniem vecumā no 2 līdz 3 gadiem, izmantojot Montesori metodiku” mērķis - izpētīt bērnu attīstību no 2 līdz 3 gadu vecumam, nosakot Montesori metodikas lomu bērnu sensoro spēju attīstīšanā. Tika veikts analītisks pētījums par bērnu attīstības teorētiskajām nostādnēm un Montesori pedagoģijas pamatbūtību, īpašu uzmanību veltot sensorās attīstības veicināšanai domātajiem materiāliem. Tika veikts praktisks pētījums par bērnu sensoro spēju...

  6. Vergleich der Imitation und Perzeption von Gesten der Finger, der Hand und des Fußes bei Patienten mit links- oder rechtszerebralen Läsionen

    OpenAIRE

    Strauß, Stefan

    2005-01-01

    Ziel der Arbeit ist es, ein bestehendes Modell zur Imitation von bedeutungslosen Gesten zu überprüfen und einen Test für die Imitation und Perzeption von Fußstellungen zu entwickeln, und in dieses Modell zu integrieren. Untersucht wurde prospektiv eine Stichprobe von 50 Patienten mit linkszerebralen (LZL) oder rechtszerebralen Läsionen (RZL) und 20 Kontrollpersonen. Patienten mit LZL haben bei der Imitation der Handstellungen mehr Schwierigkeiten als solche mit RZL, bei der Imitation der Fußs...

  7. Comparison of Targeting Distribution of PEG-5-Fu-MAMS and 5-Fu-MAMS in Pancreas under Magnetic Field%两种5-Fu磁性白蛋白微球对胰腺磁靶向性的比较

    Institute of Scientific and Technical Information of China (English)

    刘建刚; 刘志超; 孙诚谊; 钱志勇; 喻超; 王玉芝

    2007-01-01

    目的 比较磁导向下PEG修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-5-Fu-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-Fu-MAMS)对胰腺的磁靶向性,以寻求一种对胰腺癌的磁导向化疗更有效的新途径.方法 取Wistar大鼠18只,每组6只,分为5-Fu组、5-Fu-MAMS组和PEG-5-Fu-MAMS组;分别将三种不同的制剂(按5-Fu 8mg/kg)经胃左动脉注入胃十二指肠动脉,进入循环.并在胰腺表面加一表面强度为4250GS的磁场,30min后,处死大鼠取胰腺.用HPLC法检测其药物浓度.结果 PEG-5-Fu-MAMS组胰腺中的药物浓度为76.18±4.09μg/ml;5-Fu-MAMS组为57.95±6.39μg/ml;5-Fu组为16.58±3.19μg/ml.PEG-5-Fu-MAMS组的药物浓度明显高于5-Fu-MAMS组和5-Fu组,差异具有显著统计学意义(P<0.01);5-Fu-MAMS组的药物浓度明显高于5-Fu组,差异具有显著统计学意义(P<0.01).结论 PEG修饰的磁性白蛋白微球具有更好的磁靶向性和亲水性,为实现胰腺癌的主动靶向治疗提供了一种新途径.

  8. Comparison of Targeting Distribution of PEG-5-Fu-MAMS and 5-Fu-MAMS in liver%两种5-氟尿嘧啶磁性白蛋白微球对肝脏靶向性的研究

    Institute of Scientific and Technical Information of China (English)

    刘志超; 刘建刚; 孔霞

    2010-01-01

    目的:研究聚乙二醇(PEG)修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-5-5-Fu-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-Fu-MAMS)对肝脏的被动靶向性,为实现肿瘤的主动靶向治疗,减少化疗药物对肝脏的毒副作用寻找新的途径.方法:取Wistar大鼠侣只,每组6只,分为游离5-Fu组、5-Fu-MAMS组和PEG-5-Fu-MAMS组;分别将3种不同的制剂(按5-Fu 8 mg/kg)经尾静脉给药,30 min后,经眼眶采血,处死大鼠,取其肝脏.用高效液相色谱法(HPLC)法分别检测血液和肝脏中的药物浓度.结果:PEG-5-Fu-MAMS组、5-Fu-MAMS组和游离5-Fu组肝脏中的药物浓度分别为(25.21±2.98)μg/mL、(48.03±10.28)μg/mL和(15.31±2.81)μg/mL.PEG-5-Fu-MAMS组和5-Fu-MAMS组肝脏中药物浓度明显高于游离5-Fu组(P0.05).结论:PEG-5-Fu-MAMS对肝脏的被动靶向作用明显减弱,有效地减轻了药物对肝脏的毒副作用,为实现肿瘤的主动靶向治疗提供了一条新途径.

  9. Evaluación del programa de médico cirujano del Instituto de Ciencias Biomédicas de la Universidad Autónoma de Ciudad Juárez Assessment of the medical surgeon program of the Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez

    OpenAIRE

    Rafael Cataño-Calatayud; María Teresa G. Manjarrez-González; Jaime Romero-González

    2012-01-01

    Con el propósito de mejorar la calidad académica del programa de médico cirujano del Instituto de Ciencias de Biomédicas de la Universidad Autónoma de Ciudad Juárez (UACJ), en México, se modificó la manera de evaluar a los graduados. El programa de médico cirujano comprendía tres procesos de evaluación, que se utilizaron durante el periodo 2006-2008 para conocer la pertinencia, eficacia y eficiencia de la formación profesional de sus graduados: el promedio general de salida (PGS) y el examen ...

  10. Antimyosin antibody scintigraphy in patients treated with 5-fluorouracil (5-FU) and cis-platinum (CDDP); Scintigraphie aus anticorps antimyosine chez les patients traites par 5-fluorouracil (5-FU) et cis-platine (CDDP)

    Energy Technology Data Exchange (ETDEWEB)

    Muratet, J.P; Gameli, E.; Maillard, P.; Lortholary, A.; Delva, R.; Larra, P. [Centre Paul Papin, 2, rue Moll, 49033 Angers cedex 01 (France)

    1997-12-31

    The 5-FU in continuous perfusion over 96 h associated to CDDP can induce cardiac secondary effects for which a toxic myocardial origin is discussed. To locate anomalies related to myocarditis and consequently to adjust the dosing, a scintigraphy with antimyosin antibodies labelled with {sup 111}In (ScAM) was performed 7 days before the chemotherapy initiation and at the second day of it (with films at 4 d) in 14 patients, which besides benefited by clinical surveillance, ECG and FEVG (angio-scintigraphy before and at 48 h from the beginning of treatment). No clinical or ECG alteration and no significant variation of FEVG were found. The cardio-pulmonary fixation ratio (CPR) measured together with ScAM was not modified: 1.57 {+-} 0.21 [1.28 - 1.97] before treatment vs 1.54 {+-} 0.16 [1.30 - 1.90], during the treatment. The average intra-individual variation of CPR was as absolute value 8.12% {+-} 9.89% [0.60 - 29.71], only 2 patients presenting a variation larger than 20%. In absence, of clinical alteration, ECG or FEVG, the ScAM under 5-FU + CDDP does not show anomalies related to a asymptomatic myocardial affliction. Consequently, the exploration by ScAM appears to be reserved to symptomatic patients and/or to cases of asymptomatic break down by FEVG. Due to an inter-individual relatively limited dispersion of the values (m {+-} 2 ds 1.56 {+-} 0.37, in our series), establishing previously a reference individual CPR might be not indispensable

  11. Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma – CapRI: study protocol [ISRCTN62866759

    Directory of Open Access Journals (Sweden)

    Schmitz-Winnenthal H

    2005-04-01

    Full Text Available Abstract After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-year survival of 21% achieved with adjuvant chemotherapy. Investigators from the Virginia Mason Clinic have reported a 5-year survival rate of 55% in a phase II trial evaluating adjuvant chemotherapy, immunotherapy and external-beam radiation. Design The CapRI study is an open, controlled, prospective, randomised multi-centre phase III trial. Patients in study arm A will be treated as outpatients with 5-Fluorouracil; Cisplatin and 3 million units Interferon alpha-2b for 5 1/2 weeks combined with external beam radiation. After chemo-radiation the patients receive continuous 5-FU infusions for two more cycles. Patients in study arm B will be treated as outpatients with intravenous bolus injections of folinic acid, followed by intravenous bolus injections of 5-FU given on 5 consecutive days every 28 days for 6 cycles. A total of 110 patients with specimen-proven R0 or R1 resected pancreatic adenocarcinoma will be enrolled. An interim analysis for patient safety reasons will be done one year after start of recruitment. Evaluation of the primary endpoint will be performed two years after the last patients' enrolment. Discussion The aim of this study is to evaluate the overall survival period attained by chemo-radiotherapy including interferon alpha 2b administration with adjuvant chemotherapy. The influence of interferon alpha on the effectiveness of the patients' chemoradiation regimen, the toxicity, the disease-free interval and the quality of life are analysed. Different factors are tested in terms of their potential role as predictive markers.

  12. Visiones de la esperanza: recuperación de espacios públicos y generación de actividades comunitarias en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Luis Alfonso Aguirre Quiñónez

    2014-01-01

    Full Text Available A través de la descripción, interpretación e imágenes de dos situaciones de la vida fronteriza, se patentiza el anhelo de la población juarense por encontrar modos de inte - racción social que lleven a una mejora en la calidad de vida en los diversos escenarios de las relaciones humanas. Por una parte, el ensayo recupera la experiencia de un evento cívico, el desfile del 16 de septiembre, mostrando expresiones de esperanza de la pobla - ción juarense al sentirse parte del festejo en el hecho de “ganar la calle” y apropiarse del espacio público por antonomasia en Ciudad Juárez: la Plaza Principal. Por otro lado, se muestra cómo el esfuerzo de un grupo de vecinos (básicamente promovido y com - puesto por mujeres integra afectiva y socialmente a habitantes de Riberas del Bravo a través de actividades tendientes a la superación individual y a la mejoría colectiva. El evento conmemorativo en el centro de la ciudad y la acción conjunta en Riberas son muestras del anhelo de las personas de creer que la vida en esta frontera es posible de otro modo diferente al de la desconfianza y el miedo.

  13. Elaboración del duelo de una madre cuyo hijo trabajaba como sicario en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Rosalía Delgado Durán

    2014-01-01

    Full Text Available El presente trabajo es parte de una investigación cualitativa sobre el proceso de ela - boración de duelo de la madre de un sicario en el contexto de una terapia Gestalt. Se utilizó para su análisis la perspectiva de las etapas del duelo de Kübler-Ross (2006:59- 119. La exacerbación de la violencia generada en buena medida por pugnas entre gru - pos del crimen organizado en Ciudad Juárez, Chihuahua (Martínez, 2008, ha dado como resultado una gran cantidad de muertes, una de ellas es el caso que nos ocupa. Si bien uno de los objetivos iniciales de la investigación era documentar y analizar las etapas en el desarrollo del duelo de una madre a partir del fallecimiento de su hijo, este se replanteó durante el transcurso de la misma, ya que una de las características del duelo de esta madre es que inició justo cuando se enteró del trabajo que él realizaba.

  14. Seguridad urbana y vulnerabilidad social en Ciudad Juárez. Un modelo desde la perspectiva de análisis espacial

    Directory of Open Access Journals (Sweden)

    Sara Morales Cárdenas

    2013-01-01

    Full Text Available Partiendo del concepto de “seguridad urbana”, introducido por un-Habitat en 2007 dentro de la agenda de Ciudades seguras, el presente trabajo propone analizar a Ciudad Juárez, urbe considerada entre las más inseguras y violentas del país y del mundo. Se presenta el desarrollo de un índice de seguridad urbana (isu basado en un modelo multicriterio de análisis espacial que propone identificar y explicar cómo se manifiestan territorialmente las amenazas a la seguridad urbana y su relación con los índices de vulnerabilidad social asociada a la pobreza. La importancia de este análisis radica en la necesidad de articular los estudios estadísticos y los patrones de distribución de las amenazas a la seguridad urbana con los procesos de planificación urbana como instrumento preventivo que permita formular políticas para reducir la inseguridad urbana.

  15. Darba devēju un darbinieku atbildības tiesiskais regulējums darba aizsardzībā

    OpenAIRE

    Lapuška, Baiba

    2012-01-01

    Bakalaura darba „Darba devēju un darbinieku atbildības tiesiskais regulējums darba aizsardzībā” mērķis ir izpētīt normatīvo regulējumu, kas attiecas uz darba devēja un darbinieka tiesībām un pienākumiem darba aizsardzības jomā, kā arī vērst uzmanību uz problēmjautājumiem, kas skar darba devēja atbildību par darba aizsardzības neievērošanu. Autore uzskata, ka tiesu praksē nav pievērsta pietiekama uzmanība darba devēja un darbinieka atbildības tiesiskajam regulējumam darba aizsardzībā. Šis tema...

  16. Un acercamiento a la licenciatura en Ciencias de la Educación de la Universidad Juárez Autónoma de Tabasco.

    Directory of Open Access Journals (Sweden)

    Judith Pérez Castro

    2007-01-01

    Full Text Available La educación en valores se hace cada vez más necesaria en las instituciones de educación superior. Los jóvenes universitarios además de ser formados en su disciplina, necesitan construir un armazón valoral que apoye su ejercicio profesional y que les permita desempeñarse con autonomía, responsabilidad, honestidad y sentido de justicia, entre otras cosas. En este artículo, se presentan los resultados preliminares de la investigación Formación disciplinaria y ejercicio profesional. Un acercamiento a partir de los valores, la cual se lleva a cabo en la Universidad Juárez Autónoma de Tabasco. El universo de estudio lo constituyen dos generaciones de la licenciatura en Ciencias de la Educación y, además de los valores, se incluyeron otras dimensiones en donde se indaga sobre las ideas y la relación que los estudiantes mantienen con el mundo, su país, su carrera, la religión, la familia, los amigos y con ellos mismos.

  17. Tinta y política en una pequeña comunidad bonaerense: Benito Juárez, 1902-1930

    Directory of Open Access Journals (Sweden)

    Gómez, Silvana

    2016-07-01

    Full Text Available En este artículo estudiamos los vínculos entre prensa periódica y vida política en Benito Juárez, provincia de Buenos Aires, entre 1902 y 1930. El mundo político de esa comunidad estuvo atravesado en las primeras décadas del siglo XX por un personaje de impronta: Pedro Díaz Pumará. Durante la primera parte de su trayectoria política, el apoyo recibido de periódicos como La Nación y El Día fue fundamental para legitimar la posición de Don Pedro en el municipio. A partir de 1917, la importancia de la prensa local fue en aumento; en sus páginas podemos estudiar las tensiones entre oficialistas y opositores. Consideramos a lo largo de este trabajo que la prensa periódica refleja desafíos y expectativas de diversos actores, al tiempo que su estudio permite considerar el grado de afianzamiento del líder en la comunidad y sus relaciones con el espacio provincial.

  18. Teoría y práctica del desarrollo comunitario. Un estudio de caso en un fraccionamiento de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Addiel Pérez Díaz

    2016-01-01

    Full Text Available En el presente trabajo se aborda una experiencia en desarrollo comunitario acontecida en el fraccionamiento Eco 2000, en Ciudad Juárez, México. El mismo se subdivide en cuatro secciones, la primera se refiere a los fundamentos teóricos que sustentan la experiencia de intervención generada en dicha demarcación urbana. La segunda sección consiste en la concepción y estrategia metodológica asumida para el desarrollo de todo el proceso de intervención desde un enfoque participativo. La tercera parte establece un diagnóstico sobre las principales características socio-económicas prioritarias en la indagación por medio de las técnicas utilizadas. Y en la cuarta y última sección se presentan los proyectos implementados durante el periodo de cinco meses en el área mencionada

  19. A hybrid modeling approach to evaluate the groundwater flow system at the low- and intermediate-level radioactive waste disposal site in Gyeong-Ju, Korea

    Science.gov (United States)

    Ji, Sung-Hoon; Park, Kyung Woo; Lim, Doo-Hyun; Kim, Chunsoo; Kim, Kyung Su; Dershowitz, William

    2012-11-01

    The development and implementation of a hybrid discrete fracture network/equivalent porous medium (DFN/EPM) approach to groundwater flow at the Gyeong-Ju low- and intermediate-level radioactive waste (LILW) disposal site in the Republic of Korea is reported. The geometrical and hydrogeological properties of fractured zones, background fractures and rock matrix were derived from site characterization data and implemented as a DFN. Several DFN realizations, including the deterministic fractured zones and the stochastic background fractures, whose statistical properties were verified by comparison with in-situ fracture and hydraulic test data, were suggested, and they were then upscaled to continuums using a fracture tensor approach for site-scale flow simulations. The upscaled models were evaluated by comparison to in-situ pressure monitoring data, and then used to simulate post-closure hydrogeology for the LILW facility. Simulation results demonstrate the importance of careful characterization and implementation of fractured zones. The study highlighted the importance of reducing uncertainty regarding the properties and variability of natural background fractures, particularly in the immediate vicinity of repository emplacement.

  20. Gestión pública para solucionar un problema ambiental: manejo de llantas de desecho en Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Gustavo Córdova Bojórquez

    2012-01-01

    Full Text Available La reutilización de llantas usadas es un problema ambiental cuando ya no es posible seguirlas usando y se consideran basura, que se almacena en casas, se deposita en tiraderos clandestinos y se tira en la vía pública. Se convierten en refugio de plagas, roedores e insectos vectores de enfermedades, además constituyen un riesgo para el entorno y la salud humana, peligro que se incrementa ante la posibilidad de un incendio. El objetivo del presente trabajo es analizar la gestión del manejo de la llanta de desecho en Ciudad Juárez, Chihuahua, hogar del mayor tiradero de llantas en la región fronteriza. Los resultados muestran que el gobierno ha tenido una participación mínima, hasta el momento en que se inicia un proceso de gestión mixta que involucra además al sector privado, al académico y a la sociedad civil; a partir de esta gestión mixta comienzan realmente acciones específicas para resolver el problema de la llanta usada.

  1. Randomised trial comparing three different schedules of infusional 5FU and raltitrexed alone as first-line therapy in metastatic colorectal cancer. Final results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 trial.

    Science.gov (United States)

    Ducreux, M; Bouche, O; Pignon, J P; Mousseau, M; Raoul, J L; Cassan, P; Leduc, B; Berger, C; Dunant, A; Fournet, J; Bedenne, L

    2006-01-01

    LV5FU2 with high-dose leucovorin (LV), weekly infusional 5-fluorouracil (5FU) (AIO schedule) and raltitrexed have been demonstrated to be active agents in first-line treatment of colorectal cancer. We performed a 4-arm randomised trial to compare (1) a low-dose intravenous bolus of LV (20 mg/m2), followed by an intravenous bolus of 5FU (400 mg/m2), followed by a 22-hour continuous infusion of 5FU (600 mg/m2) on day 1 and day 2/2 weeks (ldLV5FU2 arm), (2) a weekly continuous infusion of high-dose 5FU (2.6 g/m2/week) for 6 weeks followed by a rest week (HD-FU arm) and (3) raltitrexed (Tomudex arm; 3 mg/m2/3 weeks) to standard LV5FU2. From 1997 to 2001, 294 patients were included. The 4 arms were well balanced for sex ratio, age, WHO performance status, the primary tumour site and prior adjuvant chemotherapy. Treatment was stopped due to low accrual. Two toxicity-related deaths were observed in the Tomudex arm. The treatments gave rise to different rates of grade 3-4 neutropenia (3, 4, 11 and 14% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively, p = 0.028), leucopenia and vomiting. At least one episode of grade 3-4 toxicity was observed in 27, 25, 38 and 47% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively (p = 0.016). An objective response was observed in 28, 21, 22 and 10% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively (p = 0.04). Progression-free survival (PFS) of the patients in the Tomudex arm was statistically lower compared to that of patients treated with LV5FU2 or ldLV5FU2 (combined group; p = 0.013, log rank test). In conclusion, Tomudex is more toxic and yields shorter PFS than infusional 5FU. Despite the early closure of the study and the lack of power of the comparison, it seems that ldLV5FU2 could be considered as an active, easier and less expensive option for the treatment of metastatic colorectal cancer compared to classic LV5FU2 or weekly HD-FU.

  2. A New Arthropod, Guangweicaris Luo, Fu et Hu gen. nov.from the Early Cambrian Guanshan Fauna, Kunming, China

    Institute of Scientific and Technical Information of China (English)

    LUO Huilin; FU Xiaoping; HU Shixue; LI Yong; HOU Shuguang; YOU Ting; PANG Jiyuan; LIU Qi

    2007-01-01

    The Guanshan Fauna is a soft-bodied fauna dominated by arthropods (including trilobites,trilobitoides, Tuzoia, Isoxys, and bradorids) in association with priapulids, brachiopods,anomalocaridids, vetulicoliids, sponges, chancellorids, and echinoderms. This paper reports and describes a new arthropod from the yellowish green mudstone at the lower part of the Wulongqing Formation, Canglangpuan Stage, Lower Cambrian in Kunming, Yunnan, China. The stratigraphic and geographic distribution, classification, fossil preservation, life style of this new arthropod and comparisons with other fossil arthropods are also discussed in details. The discovery and research of the non-mineralized arthropod, Guangweicaris Luo, Fu et Hu gen. nov. from the Guanshan Fauna adds new members to the taxonomic list and provides new information to the evolution of early arthropods.Furthermore, this study would shed new light into the "Cambrian Explosion" and the evolution of early life.

  3. The Sentimental Feelings in Cao Pi's Fu%论曹丕赋中的感伤情怀

    Institute of Scientific and Technical Information of China (English)

    张靖

    2012-01-01

    曹丕的赋具有很强的抒情性,由于特殊的政治地位和人生遭遇,使得曹丕在其赋中流露出凄凉哀婉的心境,以及孤立无援的精神状态,展现了曹丕精神世界中敏感脆弱的一面。%Cao Pi' s Fu has strong lyricism due to the special political status and life experience. Cao Pi in his ode re- veals the desolate pathos mood, as well as the isolated and helpless mental state, which shows Cao Pi' s spiritual world of fragile and sensitive side.

  4. 试论沈光文《台湾赋》%A Trial Discussion on Taiwan Fu by Shen Guangwen

    Institute of Scientific and Technical Information of China (English)

    袁韵

    2016-01-01

    沈光文的《台湾赋》是台湾赋体文学的开山之作,因其对台湾历史、地理、物产、民俗等的全方位反映,而有“第一部台湾简史”之誉,具有珍贵的史料价值。《台湾赋》对荷兰殖民者入侵历史的痛斥,对郑成功金陵之役、驱荷复台之役的客观评价,都反映了作者进步的历史观;其对郑经的批评,则反映了作为鲁王侍臣的沈光文对封建礼法正统性的维护。%Shen Guangwen’ s Taiwan Fu is the groundbreaking work of the Taiwan ode literature,which is honored as“The first brief history of Taiwan” with great documentary value based on its comprehensive re⁃flection on Taiwan history,geography,property and folk customs. Taiwan Fu reflects the author’s progressive historical viewpoint and political attitude in terms of not only the denunciation of the invasion history of the Dutch colonialists,but also the evaluation of Jinling battle and recapture battle led by Zheng Chenggong.The criticism of Zheng Jing reflects the maintenance of the legitimacy of feudal etiquette based on Shen Guangwen’s identity as the courtier of Lu Wang.

  5. Calculating clear-sky radiative heating rates using the Fu-Liou RTM with inputs from observed and reanalyzed profiles

    Science.gov (United States)

    Dolinar, E. K.; Dong, X.; Xi, B.

    2015-12-01

    One-dimensional radiative transfer models (RTM) are a common tool used for calculating atmospheric heating rates and radiative fluxes. In the forward sense, RTMs use known (or observed) quantities of the atmospheric state and surface characteristics to determine the appropriate surface and top-of-atmosphere (TOA) radiative fluxes. The NASA CERES science team uses the modified Fu-Liou RTM to calculate atmospheric heating rates and surface and TOA fluxes using the CERES observed TOA shortwave (SW) and longwave (LW) fluxes as constraints to derive global surface and TOA radiation budgets using a reanalyzed atmospheric state (e.g. temperature and various greenhouse gases) from the newly developed MERRA-2. However, closure studies have shown that using the reanalyzed state as input to the RTM introduces some disparity between the RTM calculated fluxes and surface observed ones. The purpose of this study is to generate a database of observed atmospheric state profiles, from satellite and ground-based sources, at several permanent Atmospheric Radiation Measurement (ARM) Program sites, including the Southern Great Plains (SGP), Northern Slope of Alaska (NSA) and Tropical Western Pacific Nauru (TWP-C2), and Eastern North Atlantic (ENA) permanent facilities. Since clouds are a major modulator of radiative transfer within the Earth's atmosphere, we will focus on the clear-sky conditions in this study, which will set up the baseline for our cloudy studies in the future. Clear-sky flux profiles are calculated using the Edition 4 NASA LaRC modified Fu-Liou RTM. The aforementioned atmospheric profiles generated in-house are used as input into the RTM, as well as from reanalyses. The calculated surface and TOA fluxes are compared with ARM surface measured and CERES satellite observed SW and LW fluxes, respectively. Clear-sky cases are identified by the ARM radar-lidar observations, as well as satellite observations, at the select ARM sites.

  6. Ultrasound-activated agents comprised of 5FU-bearing nanoparticles bonded to microbubbles inhibit solid tumor growth and improve survival.

    Science.gov (United States)

    Burke, Caitlin W; Alexander, Eben; Timbie, Kelsie; Kilbanov, Alexander L; Price, Richard J

    2014-02-01

    Nanoparticle (NP) drug delivery vehicles may eventually offer improved tumor treatments; however, NP delivery from the bloodstream to tumors can be hindered by poor convective and/or diffusive transport. We tested whether poly(lactic-co-glycolic acid) NP delivery can be improved by covalently linking them to ultrasound (US)-activated microbubbles in a "composite-agent" formulation and whether drug 5-fluorouracil (5FU)-loaded NPs delivered in this fashion inhibit the growth of tumors that are typically not responsive to intravenously administered 5FU. After intravenous composite-agent injection, C6 gliomas implanted on Rag-1(-/-) mice were exposed to pulsed 1 MHz US, resulting in the delivery of 16% of the initial NP dose per gram tissue. This represented a five- to 57-fold increase in NP delivery when compared to multiple control groups. 5FU-bearing NP delivery from the composite-agent formulation resulted in a 67% reduction in tumor volume at 7 days after treatment, and animal survival increased significantly when compared to intravenous soluble 5FU administration. We conclude that NP delivery from US-activated composite agents may improve tumor treatment by offering a combination of better targeting, enhanced payload delivery, and controlled local drug release.

  7. Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.

    Science.gov (United States)

    Di Gennaro, Elena; Bruzzese, Francesca; Pepe, Stefano; Leone, Alessandra; Delrio, Paolo; Subbarayan, Pochi R; Avallone, Antonio; Budillon, Alfredo

    2009-05-01

    Despite the introduction of several novel anticancer agents almost 50% of colorectal cancer (CRC) patients die for cancer suggesting the necessity of new therapeutical approaches. In this study we demonstrated that the HDAC inhibitor vorinostat exerted potent antiproliferative effect in a panel of mut- and wt-p53 human CRC cell lines. Moreover, in combination with 5-fluorouracil modulated by folinic acid (5FU-FA) or with Raltitrexed (RTX), both commonly used in the treatment of this disease, it showed a clear schedule-dependent synergistic antiproliferative interaction as demonstrated by calculating combination indexes. Only simultaneous, or 24 h pretreatment with vorinostat followed by either agent, produced synergistic effect paralleled by evident cell cycle perturbations with major S-phase arrest. Moreover, we provided for the first time evidences that vorinostat can overcome resistance to both 5FU and RTX. Downmodulation of Thymidilate synthase (TS) protein induced by vorinostat within 24 h, represented a key factor in enhancing the effects of both drugs in sensitive as well as resistant tumor cells. Furthermore, p53, whose wild-type expression is critical for sensitivity to 5FU and RTX, was upregulated by vorinostat in wt- and downregulated in mut-p53 cells, suggesting an additional mechanism of the antiproliferative synergistic interactions observed. Overall these data add new insights in the mechanism of vorinostat antitumor effect and suggested that the association of vorinostat plus 5FU-FA and/or RTX should be clinically explored.

  8. 傅山医事和医学著述略考%Research on Medical Events and Medical Writings of Fu Shan

    Institute of Scientific and Technical Information of China (English)

    郑梅玲

    2016-01-01

    Fu Shan, a famous thinker, painter, poet and doctor in the Ming and Qing dynasties, is an expert in medicine and medical theories, and invented effective formulae for disease treatment. He had great achievements in gynecology, andrology, pediatrics, obstetrics, etc. This article combed the existing medical writings of Fu Shan by organizing recordings of medical events of FU Shan in historical literature, and expounded the important achievements of Fu Shan made to TCM.%傅山是明清之际著名的思想家、书画家、诗人和医生。他精通医学医理,治验有奇方,在女科、男科、儿科、产科等都有建树。本文通过整理历史文献中对傅山医事的记载,梳理其流传在世的医学著述,阐述傅山对中医学的重要贡献。

  9. 制度视野下的辞赋创作——以清代乾嘉时期为中心%Fu Writing in Perspective of Institution: a Case Study of Qianlong and Jiaqing Periods in Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    孙福轩

    2012-01-01

    清代是古代赋学的集大成期,无论是辞赋创作还是赋论都有十分重要的历史地位。赋学的繁荣除了统治者的辞赋创作与提倡外,科举试赋也是一个十分重要的因素,特别是乾嘉时期,针对律赋创作的疲苶倾向,赋论家提出"以古文为时文"的创作要求,既是辞赋文体自身的救赎,也是应合科举试赋的统治阶级意向的表现,对后期辞赋创作及古代赋学理论产生了积极的影响,而赋论强调"丽则"的观念也可以说是统治政策在文体风格方面的必然反映。%The Qing Dynasty plays an important role in Fu writing and study in ancient China.Besides ruler' s Fu writing and promotion,Fu test in imperial examinations is main factor to prosper Fu study.In Qianlong and Jiaqing periods,the writing of rhymed Fu was sluggish and Fu researchers proposed a requirement by taking ancient Chinese literary style as style of that time.This is not only the salvation of the style of Fu,but also a demonstration to respond the will of the ruling class of examining Fu in imperial examinations.This trend plays a positive role in later Fu writing and ancient Fu theory.The idea of stressing the principle for beauty can be regarded as a necessary reflection of rule policy in literary style.

  10. Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

    Directory of Open Access Journals (Sweden)

    Ana de la Cueva

    Full Text Available BACKGROUND: Colorectal cancer (CRC is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα, an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in many different tumors, including colorectal tumors. ChoKα inhibitors have recently entered clinical trials as a novel antitumor strategy. METHODOLOGY/PRINCIPAL FINDINGS: ChoKα specific inhibitors, MN58b and TCD-717, have demonstrated a potent antitumoral activity both in vitro and in vivo against several tumor-derived cell line xenografts including CRC-derived cell lines. The effect of ChoKα inhibitors in combination with 5-FU as a new alternative for the treatment of colon tumors has been investigated both in vitro in CRC-tumour derived cell lines, and in vivo in mouse xenografts models. The effects on thymidilate synthase (TS and thymidine kinase (TK1 levels, two enzymes known to play an essential role in the mechanism of action of 5-FU, were analyzed by western blotting and quantitative PCR analysis. The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. ChoKα inhibitors modulate the expression levels of TS and TK1 through inhibition of E2F production, providing a rational for its mechanism of action. CONCLUSION/SIGNIFICANCE: Our data suggest that both drugs in combination display a synergistic antitumoral effect due to ChoKα inhibitors-driven modulation of the metabolization of 5-FU. The clinical relevance of these findings is strongly supported since TCD-717 has recently entered Phase I clinical trials against solid tumors.

  11. E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.

    Science.gov (United States)

    Sulzyc-Bielicka, Violetta; Domagala, Pawel; Bielicki, Dariusz; Safranow, Krzysztof; Rogowski, Wojciech; Domagala, Wenancjusz

    2016-07-01

    The predictive value of thymidylate synthase (TS) expression alone for 5FU-based treatment of colorectal cancer (CRC) has not been clinically confirmed. Little is known on the association of expression of E2F1, which controls the transcription of genes encoding proteins engaged in DNA synthesis including TS, and survival of patients with CRC. The purpose of this study is to assess the correlation between expression of both E2F1 and TS in CRCs and survival of patients administered adjuvant 5FU-based chemotherapy, in order to find a better predictor of treatment outcome than expression of TS or E2F1 alone. Nuclear TS and E2F1 were detected by immunohistochemistry in tissue microarrays from 190 CRCs (Astler-Coller stage B2 or C). Multivariate analysis identified significant association of the combined E2F1+TS+ immunophenotype with worse OS (HR = 3,78, P = 0,009) and DFS (HR = 2,30, P = 0,03) of patients with colon cancer. There were significant differences between E2F1+TS+ and E2F1-TS- Kaplan-Meier survival curves in relation to DFS (P = 0.008) and OS (P = 0.01). About 37 and 31 % difference in 3-year DFS and OS respectively were seen between patients with E2F1+TS+ vs. E2F1-TS- colon cancer immunophenotype. The E2F1+TS+ immunophenotype may be a marker of poor prognosis (the worst DFS and OS) of patients with colon cancer treated with 5FU-based adjuvant therapy. A subgroup of patients with this immunophenotype may require different and perhaps more aggressive treatment than 5FU-based chemotherapy. Thus, the combined E2F1/TS immunophenotype could be a potential indicator of colon cancer sensitivity to 5FU.

  12. [Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

    Science.gov (United States)

    Kimoto, M; Nagano, H; Sano, K

    1987-10-01

    The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

  13. 赋之比喻审美发展演变论%A Study of Parable Aesthetic Developments in Fu(赋)

    Institute of Scientific and Technical Information of China (English)

    冯广艺; 何婷婷

    2016-01-01

    赋是我国古代特色鲜明的一种文体,兴盛于汉代,衰落于近代。从比喻审美的角度看,汉赋中的比喻能够再现自然美,籦丽铺排,讲求修饰,辞藻华丽,气势恢宏,具有宏丽美。魏晋南北朝时期,赋中比喻突出自然美,彰显内容美,具有形象美。唐宋时期,赋中比喻凸显通俗美、情感美和形式美。金元明清时期,赋中比喻巧妙选择喻体,突出形象美;寓情于景,抒发情怀,具有情意美;比喻与其他辞格合用,结构精巧,富有形式美。%Fu(赋)is a kind of style of Chinese ancient times,which flourished in the Han Dynasties and declined in modern times.The parables in the Han Fu(赋)reproduced natural beauty,emphasized the modi-fications and rhetoric.They were magnificent,and they were provided with gorgeous beauty.During the period of the Wei,Jin and Southern and Northern Dynasties,the parables in Fu(赋)had natural beauty,content beauty and image beauty.The Tang and Song Dynasties,the parables in Fu displayed popular beauty,emo-tional beauty and formal beauty.The Jin,Yuan,Ming and Qing Dynasties,the parables in Fu showed image beauty,cordial beauty and formal beauty.

  14. Por que Kant escreve duas introduções para a crítica da faculdade do juízo?

    Directory of Open Access Journals (Sweden)

    Adriano Perin

    2010-06-01

    Full Text Available A busca de uma função sistemática para a Crítica da faculdade do juízo frente à autossuficiência dos domínios teórico e prático da razão, que é o resultado que a filosofia crítica kantiana alcança no final da década de 1780 na argumentação da segunda Crítica, suscita a necessidade de um empreendimento que possa garantir a "conexão" (Verknüpfung ou o "meio de ligação" (Verbindungsmittel desses domínios. Vale dizer que as duas primeiras críticas garantem a natureza e a liberdade como duas legalidades determinantes apenas no âmbito inerente aos seus domínios próprios. Assim sendo, a terceira Crítica atesta agora um "grande abismo" entre o domínio teórico e o domínio prático da razão. No presente trabalho objetiva-se reconstruir a argumentação das duas introduções da Crítica da faculdade do juízo sustentando que a percepção da necessidade de um novo texto para a introdução da obra está intrinsecamente ligada ao peso sistemático da abordagem do problema da possibilidade de uma passagem (Übergang entre o domínio teórico da legalidade da natureza e o domínio prático da legalidade da liberdade.In face of the self-sufficiency of the theoretical and practical domains of reason, which is the outcome reached by the critical philosophy at the end of the 1780s in the second Critique's argumentation, the search for a systematic function for the Critique of the Power of Judgment calls for an enterprise accomplishing the connection (Verknüpfung or the means for combining (Verbindungsmittel these domains. Nature and freedom are guaranteed by the first two critiques as determining legalities only within their own domains. The third Critique is therefore able to attest to a "great gulf" between the theoretical and practical domains of reason. By reconstructing the argumentation of both introductions to the Critique of the Power of Judgment, the paper defends that the systemic weight given to the consideration of

  15. Intervención nutricional en un Grupo de Ayuda Mutua del municipio de "El Rosario", Oaxaca de Juárez, México

    Directory of Open Access Journals (Sweden)

    Alejandra Soledad Jiménez-León

    Full Text Available Introducción: los grupos de ayuda mutua se forman con la finalidad de atender a adultos mayores con problemas crónicos-degenerativos. La organización y participación activa de los integrantes favorece la intervención del nutriólogo y, por ende, cambios en el estilo de vida de los participantes, sobrellevando de mejor manera sus vidas. Objetivo: intervenir nutricionalmente en individuos del Grupo de Ayuda Mutua del Centro de Salud C-2, "El Rosario" de Oaxaca de Juárez, México. Material y métodos: se trató de un estudio observacional, descriptivo, analítico y longitudinal, llevado a cabo desde noviembre/2014 hasta julio/2015, evaluando el estado nutricional antes y después de la intervención, buscando la correlación entre índice de masa corporal (IMC, glucosa capilar, hemoglobina glicada con las consultas-talleres brindadas. Resultados: la muestra trabajada fue de 15 participantes del Grupo de Ayuda Mutua con un promedio de edad de 55,26 años, con un IMC de 28,74 kg/cm², glucosa capilar de 218,66 mg/dl y una hemoglobina glicada de 10,43%. Al finalizar la intervención se correlacionaron entre sí mediante Spearman, dando como resultado el valor de 1, es decir, una correlación positiva perfecta. Conclusión: el nutriólogo juega hoy en día un papel importante en el hecho de atender enfermedades crónico-degenerativas, a través del seguimiento en consultas y talleres propuestos. Los grupos de ayuda mutua día a día se posicionan como una estrategia en la línea educativa para mejorar el control de las enfermedades.

  16. de la industria maquiladora para la exportación en Ciudad Juárez: una solución factorial

    Directory of Open Access Journals (Sweden)

    Andrés Hernández Gómez

    2015-01-01

    Full Text Available En este artículo se presentan los resultados de un estudio efectuado a personal rela - cionado con el proceso de implantación del Mantenimiento Productivo Total (MPT en empresas de la industria maquiladora de Ciudad Juárez, Chihuahua, México. Se aplicó un Análisis Factorial para identificar los Factores Críticos de Éxito (FCE vinculados con la implantación del MPT. El artículo inicia con la revisión del estado del arte que se llevó a cabo para la identificación de los FCE, los cuales están organizados en aspectos estratégi - cos y administrativos, del desarrollo del recurso humano y técnicos propios del MPT. Con esta información se construyó un instrumento para determinar los FCE en las plantas. La tercera sección describe la metodología, se valida el cuestionario y se justifica la aplicación de las pruebas estadísticas y el Análisis Factorial. La cuarta sección presenta los resultados, iniciando con la descripción del muestreo, conformado por 306 sujetos vinculados con la implantación del MPT. Se identificaron nueve factores críticos de éxito relacionados con la implantación efectiva del MPT, y se discuten sus efectos. Derechos Reservados©2015 Universidad Nacional Autónoma de México, Facultad de Contaduría y Administración. Este es un artículo de acceso abierto distribuido bajo los términos de la Licencia Creative Commons CC BY-NC-ND 4.0.

  17. Concurrent sexual partnerships among female sex workers and their non-commercial male partners in Tijuana and Ciudad Juárez, Mexico

    Science.gov (United States)

    Robertson, Angela M.; Syvertsen, Jennifer L.; Rangel, M. Gudelia; Staines, Hugo S.; Morris, Martina; Patterson, Thomas L.; Ulibarri, Monica D.; Strathdee, Steffanie A.

    2013-01-01

    Objectives To investigate the prevalence and correlates of concurrent (overlapping) sexual partnerships among female sex workers (FSWs) and their non-commercial male partners in two Mexico-U.S. border cities. Methods A cross-sectional survey of FSWs and their non-commercial male partners was conducted in Tijuana and Ciudad Juárez, Mexico (2010–2011). Eligible FSWs and verified non-commercial partners were aged ≥18 years; FSWs had ever used hard drugs (lifetime) and recently exchanged sex for money, drugs, or other goods (past month). Participants underwent baseline questionnaires obtaining dates of sex and condom use with ≤5 other recurring partners, including FSWs’ regular clients. These dates were compared to dates of sex with enrolled study partners to determine overlap (i.e., “recurring” concurrency). Bivariate probit regression identified recurring concurrency correlates. Results Among 428 individuals (214 couples), past-year recurring concurrency prevalence was 16% and was higher among women than their non-commercial male partners (26% vs. 6%). In 10 couples (5%), both partners reported recurring concurrency. The majority of couples (64%) always had unprotected sex, and most of the individuals (70%) with recurring concurrency “sometimes” or “never” used condoms with their concurrent partners. Recurring concurrency was positively associated with FSWs’ income, men’s caballerismo (a form of traditional masculinity), and men’s belief that their FSW-partners had STIs. Conclusions Recurring concurrency, representing sustained periods of overlapping partnerships in which unprotected sex was common, should be addressed by couple-based STI prevention interventions. PMID:23172036

  18. La estructura urbana y las diferencias espaciales en el tiempo de traslado del viaje al trabajo en Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    César M. Fuentes Flores

    2008-01-01

    Full Text Available Este artículo tiene como objetivo analizar las diferencias intraurbanas en los tiempos de traslado del viaje al trabajo en transporte público y privado, asociado a variables de uso del suelo (razón empleo/viviendas, densidad de población, valor del suelo, a características socioeconómicas (proporción de población con ingreso bajo y alto, y a la tenencia de la vivienda (proporción de viviendas propias y rentadas en Ciudad Juárez, Chihuahua. Las variables fueron construidas con información de la Encuesta de Origen-Destino 1997 (IMIP, el XII Censo de Ppoblación y Vivienda 2000 (INEEGI y el XIII Censo Económico 1999 (INEEGI a nivel de AGEB. El análisis se realizó mediante la construcción de cuatro modelos de regresión que se estimaron mediante la técnica de mínimos cuadrados ordinarios. Los resultados muestran que las variables razón empleo/viviendas, valor del suelo, y proporción de viviendas rentadas son estadísticamente significativas para explicar menores tiempos de traslado en transporte público. En contraste, la densidad de población y la proporción de viviendas propias son estadísticamente significativas para explicar menores tiempos de traslado en transporte público. La proporción de población de bajos ingresos es estadísticamente significativa para explicar los cambios en los tiempos de traslado en transporte privado.

  19. Prevalencia de asma y otras enfermedades alérgicas en niños escolares de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Barraza-Villarreal Albino

    2001-01-01

    Full Text Available Objetivo. Determinar la prevalencia y severidad del asma, de la rinitis y del eczema en escolares. Material y métodos. Estudio transversal efectuado entre abril de 1998 y mayo de 1999 en Ciudad Juárez, Chihuahua, México, a una muestra aleatoria de 6 174 niños de 53 escuelas. Se aplicó la metodología propuesta por el International Study of Asthma and Allergies in Childhood (ISAAC (etapas 1 y 2 para determinar la prevalencia y severidad del asma, rinitis y eczema. La información de prevalencia, tanto actual como acumulada para dichos padecimientos, se obtuvo mediante un cuestionario ya estandarizado y contestado por los padres de los niños. El diseño de la muestra se hizo por un muestreo mixto, en el cual se estratificó por nivel de contaminación ambiental. Se estimaron prevalencias actual y acumulada estratificando por grupo de edad, sexo, área e historia familiar de asma. Resultados. La prevalencia acumulada de asma por diagnóstico médico y sibilancia (silbidos fue de 6.8% (IC95% 6.2-7.4 y 20.% (IC95% 19.7-21.8, respectivamente; la prevalencia de sibilancia en los últimos 12 meses fue mayor en el grupo de 6-8 años que en el de 11-14 años(9.7% contra 5.8% (phttp://www.insp.mx/salud/index.html

  20. Effects of Artemis on DNA damage of human hepatic carcinoma cell line BEL-7402/5FU%Artemis对人肝癌细胞系BEL-7402/5FU DNA损伤的影响

    Institute of Scientific and Technical Information of China (English)

    张雪; 李大玉; 祝小波; 范芳; 刘云; 李长福

    2016-01-01

    目的 探讨转染shArtemis干扰质粒对人肝癌细胞BEL-7402/5FU DNA损伤的影响.方法 将人肝癌细胞分为正常对照组、脂质体对照组、空质粒对照组和转染shArtemis干扰质粒实验组(shArtemis实验组);建立DNA损伤模型,分别用0.625、1.25、2.5、5.0和10.0 μg/mL的丝裂霉素C作用BEL-7402/5FU细胞24和48 h,MTT法检测细胞活性,Western blot观察磷酸化组蛋白H2AX(γ-H2AX)的表达;转染Artemis干扰质粒,检测Artemis、γ-H2AX表达;彗星实验检测DNA的损伤.结果 0.625、1.25、2.5、5.0和10.0 μg/mL的丝裂霉素C作用48h后肝癌细胞活力明显下降(P<0.05);丝裂霉素C刺激细胞48 h后,γ-H2AX的表达量随着药物浓度的增加而增加;转染shArtemis干扰质粒后,γ-H2AX的表达量较正常对照组增加(P<0.05);shArtemis实验组较正常对照组拖尾DNA量增加(P<0.05).结论 丝裂霉素C能够诱导肝癌细胞损伤;转染shArtemis干扰质粒促进丝裂霉素C诱导的人肝癌细胞BEL-7402/5FU DNA损伤.

  1. Conference overview of "Academic seminar for commemorating the 1 300th birthday of DU Fu and the 6th annual conference of Chinese seminar of DU Fu"%“纪念杜甫诞生1300周年学术研讨会暨中国杜甫研究会第六届年会”会议综述

    Institute of Scientific and Technical Information of China (English)

    姜一慧; 张倩

    2012-01-01

    为纪念诗圣杜甫诞生1300周年,各地专家学者在古都西安隆重集会。会议议题涉及杜甫的生平和思想与创作、杜诗学、杜诗研究与当下诗词创作、域外杜诗研究、杜甫与长安、杜诗与长安文化等。会议的学术研讨集中体现了以下几大特色:时代气息,文化研究;最新成果,集中展示;命题集中,亮点突出;回归学术,精神传承。%DU Fu was a great poet in the history of China and even the world. In order to commemorate the 1 300th birthday of the spoet-sage, scholars from various places held a conference in the ancient cap- ital Xi'an. The topics of the conference involved the lifetime, thoughts and works of DU Fu, studies on DU Fu's poems, current poetry creation, foreign studies on DU Fu's poems, DU Fu and Chang'an, and DU Fu's poems and Chang'an culture, etc. The following characteristics were reflected by the conference, including the spirit of the times and the cultural studies; intensive display of the latest achievement; the centralized topics with highlights and academic return with spirit inheritance.

  2. A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach.

    Science.gov (United States)

    Saif, Muhammad Wasif; Lee, Adam M; Offer, Steven M; McConnell, Kathleen; Relias, Valerie; Diasio, Robert B

    2014-01-01

    5-Fluorouracil (5-FU) is commonly administered as a therapeutic agent for the treatment of various aggressive cancers. Severe toxic reactions to 5-FU have been associated with decreased levels of dihydropyrimidine dehydrogenase (DPD) enzyme activity. Manifestations of 5-FU toxicity typically include cytopenia, diarrhea, stomatitis, mucositis, neurotoxicity, and, in extreme cases, death. A variety of genetic variations in DPYD, the gene encoding DPD, are known to result in decreased DPD enzyme activity and to contribute to 5-FU toxic effects. Recently, it was reported that healthy African American individuals carrying the Y186C DPYD variant (rs115232898) had significantly reduced DPD enzyme activity compared with noncarriers of Y186C. Herein, we describe for the first time, to our knowledge, an African American patient with cancer with the Y186C variant who had severe toxic effects after administration of the standard dose of 5-FU chemotherapy. The patient lacked any additional toxic effect-associated variations in the DPYD gene or the thymidylate synthase (TYMS) promoter. This case suggests that Y186C may have contributed to 5-FU toxicity in this patient and supports the use of Y186C as a predictive marker for 5-FU toxic effects in individuals of African ancestry.

  3. 茯砖茶茶汤稳定性研究%Study on Stability of Fu-brick Tea Infusion

    Institute of Scientific and Technical Information of China (English)

    黄亚亚; 梁艳; 邓永亮; 陈桂梅; 纪晓明; 周兴长; 胡歆

    2012-01-01

    为探讨茯砖茶茶汤的稳定性,采用茯砖茶原料制作茶汤,分别在贮藏后0、7、14、21、35、42 d对茶汤中的水浸出物、多酚类、咖啡碱、氨基酸、可溶性糖、儿茶素组分含量及茶汤pH值、色泽等进行检测分析.结果表明,贮藏后0~35 d,水浸出物、多酚类、咖啡碱、氨基酸、可溶性糖、儿茶素组分含量基本稳定,上下波动幅度不明显,茶汤pH值及色泽也较稳定;贮藏后35~42 d,水浸出物、多酚类、咖啡碱、氨基酸、儿茶素组分含量急剧下降,可溶性糖含量较稳定,茶汤pH值减小,酸度增加,且色泽逐渐加深.由此可见,茯砖茶茶汤在贮藏35 d后,水浸出物、多酚类、咖啡碱、氨基酸、儿茶素组分含量减少较多,茶汤褐变严重,且产生较多沉淀.%To discuss the stability of Fu-brick tea infusion,the experiment analyzed main chemical components of Fu-brick tea beverage respectively on 0,7,14,21,35,42 days of storage, such as water extract,tea polyphenols,amino acids,caffeine,water-soluble sugar,catechin component,pH and color. The result showed that during 0 — 35 days of storage the contents of water extract,tea polyphenols,amino acids,caffeine,water-soluble sugar and catechin component were basically stable without apparent fluctuations,which fell sharply during 35 — 42 days of storage except the stable water-soluble sugar. The pH and colour remained steady during the first 35 days of storage, while tea infusion pH decreased and tea infusion color deepened gradually with more acids during 35 — 42 days. It demonstrated that after the first 35 days of storage the compositions of Fu-brick tea beverage such as water extract,tea polyphenols,amino acids,caffeine,catechin component reduced obviously,and there appeared more precipitations and a severe browning in tea color.

  4. The large amplitude outburst of the young star HBC 722 in NGC 7000/IC 5070, a new FU Orionis candidate

    Science.gov (United States)

    Semkov, E. H.; Peneva, S. P.; Munari, U.; Milani, A.; Valisa, P.

    2010-11-01

    Context. The investigations of the photometric and spectral variability of PMS stars are essential to a better understanding of the early phases of stellar evolution. We are carrying out a photometric monitoring program of some fields of active star formation. One of our targets is the dark cloud region between the bright nebulae NGC 7000 and IC 5070. Aims: We report the discovery of a large amplitude outburst from the young star HBC 722 (LkHα 188 G4) located in the region of NGC 7000/IC 5070. On the basis of photometric and spectroscopic observations, we argue that this outburst is of the FU Orionis type. Methods: We gathered photometric and spectroscopic observations of the object both in the pre-outburst state and during a phase of increase in its brightness. The photometric BVRI data (Johnson-Cousins system) that we present were collected from April 2009 to September 2010. To facilitate transformation from instrumental measurements to the standard system, fifteen comparison stars in the field of HBC 722 were calibrated in the BVRI bands. Optical spectra of HBC 722 were obtained with the 1.3-m telescope of Skinakas Observatory (Crete, Greece) and the 0.6-m telescope of Schiaparelli Observatory in Varese (Italy). Results: The pre-outburst photometric and spectroscopic observations of HBC 722 show both low amplitude photometric variations and an emission-line spectrum typical of T Tau stars. The observed outburst started before May 2010 and reached its maximum brightness in September 2010, with a recorded ΔV ~ 4.7m amplitude. Simultaneously with the increase in brightness the color indices changed significantly and the star became appreciably bluer. The light curve of HBC 722 during the period of rise in brightness is similar to the light curves of the classical FUors - FU Ori and V1057 Cyg. The spectral observations during the time of increase in brightness showed significant changes in both the profiles and intensity of the spectral lines. Only Hα remained in

  5. Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Bigam David

    2004-07-01

    Full Text Available Abstract Background Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive to the agents administered. One potential advantage of neoadjuvant chemotherapy is that it provides in vivo chemosensitivity data. Response to neoadjuvant chemotherapy could therefore guide adjuvant chemotherapy following resection of liver metastases from colorectal cancer. Methods and design This is a prospective Phase II evaluation of outcomes in patients with potentially resectable liver metastases. Patients will receive neoadjuvant chemotherapy and will undergo resection. Postoperative chemotherapy will be directed by the degree of response to preoperative chemotherapy. All patients with Stage IV colorectal adenocarcinoma isolated to the liver that have disease that is amenable to complete ablation by resection, radiofrequency ablation, and/or cryoablation will be candidates for the trial. Patients will receive CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2, every 2 weeks. Altogether, six cycles of chemotherapy will be administered. Patients will then undergo resection and/or radiofrequency ablation. Patients who had stable disease or a clinical response with preoperative chemotherapy will receive an additional 12 cycles of CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2 (given every 2 weeks. Patients with resectable disease who had progressive disease during neoadjuvant chemotherapy will receive best supportive care or an alternative agent, at the discretion of the treating physician. Those patients who are

  6. 王士祯的杜甫研究%Wang Shizhen's Study of Du Fu

    Institute of Scientific and Technical Information of China (English)

    刘文刚

    2012-01-01

    Wang Shizhen's study of Du Fu was characterized most prominently by his special research thought and methods under the guideline of combining Confucian thought and his romantic charm theory. He viewed Du's poems as "Du Fu's devout eloquence" and believed that "with sincere loyalty and patriotism, they are faithful to the current events and highly regarded as historical poems", "what they are far better than others is its faithfulness to the reality", and that their artistic greatness lay in the "grand narrative recording current events faithfully with new poetic meters", "which is fu's advantage, with the function of analogy? and punning". Additionally, Wang did an extensive research on Du Fu. For example, he conducted field studies to Du's living thought and poem content, did text research on certain names and descriptions in Du's poems, on their different versions, and studied Du's influence on the great poets of the later period from the perspective of communications.%王士祯研究杜甫的最大特点,就是将儒家思想与自己的神韵理论结合起来作为研究的指导思想,形成独到的思路与方法。他对杜诗的总体评价是"杜甫圣语"。他认为杜诗"纯以忠君爱国为气骨。故形之篇章,感时纪事,则人尊诗史之称","其大过人处在诚实耳"。论杜诗的艺术的伟大是"以雄辞直写时事,以创格而纾鸿文","此正一主于赋,而兼比兴之旨者也"。王士祯对杜甫的研究非常广泛。他游宦到杜甫漂泊和生活的地方,实地考察研究杜甫的生活思想和杜诗的内容。他考释杜诗的一些名物,研究杜诗的一些版本文字,还从传播学的角度研究杜甫对后世重要诗人的影响。

  7. Evaluación del programa de médico cirujano del Instituto de Ciencias Biomédicas de la Universidad Autónoma de Ciudad Juárez Assessment of the medical surgeon program of the Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez

    Directory of Open Access Journals (Sweden)

    Rafael Cataño-Calatayud

    2012-12-01

    Full Text Available Con el propósito de mejorar la calidad académica del programa de médico cirujano del Instituto de Ciencias de Biomédicas de la Universidad Autónoma de Ciudad Juárez (UACJ, en México, se modificó la manera de evaluar a los graduados. El programa de médico cirujano comprendía tres procesos de evaluación, que se utilizaron durante el periodo 2006-2008 para conocer la pertinencia, eficacia y eficiencia de la formación profesional de sus graduados: el promedio general de salida (PGS y el examen profesional ante pacientes (EPAP, evaluados por la UACJ, y el examen general para el obtención de la licenciatura (EGEL, evaluado por el Centro Nacional de Evaluación para la Educación Superior (CENEVAL. Se emplearon los procesos de evaluación con el fin de obtener un mejor perfil del grado. Se obtuvo una correlación entre el PGS y el EPAP, pero no con el EGEL, el cual tuvo una diferencia porcentual apreciable respecto a los otros dos procesos. Mientras que el EPAP reflejó los conocimientos obtenidos a lo largo del programa (comparado con el PGS, el EGEL mostró una diferencia marcada, probablemente, al evaluar con diversas puntuaciones las diferentes disciplinas del programa.In order to improve the program of surgeon of the Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez (UACJ the graduate evaluating procedure was modified. Three processes were selected for evaluation by the medical surgeon program during the period 2006-2008 to determine the relevance, effectiveness and efficiency of its graduates, which are: the overall grade point average (GPA and the professional medical exam (PME taken with real patients at a hospital, evaluated by the UACJ, and the general exam for graduates (GEG, evaluated by the National Center for the Evaluation of Higher Education (CENEVAL. The evaluation processes were used in order to get a better graduate profile. Correlation was obtained between the GPA and the PME but not with the

  8. Diversidad del género Amanita en dos áreas con diferente condición silvícola en Ixtlán de Juárez, Oaxaca, México Diversity of the genus Amanita in two areas with different forestry management in Ixtlán de Juárez, Oaxaca, Mexico

    Directory of Open Access Journals (Sweden)

    Emmanuel Villanueva-Jiménez

    2006-06-01

    Full Text Available Se estudió la diversidad de especies de Amanita presentes en dos áreas de bosque de Pinus-Quercus con diferente manejo silvícola en la comunidad de Ixtlán de Juárez, Oaxaca. Las recolectas se realizaron durante una temporada de lluvias, obteniéndose un total de 107 ejemplares que corresponden a 36 especies, de las cuales 21 pertenecen al subgénero Amanita y 15 al subgénero Lepidella; 14 nuevos registros son para el estado de Oaxaca y 19 para la comunidad de Ixtlán en particular. La abundancia de especies estuvo correlacionada con la precipitación y condiciones ecológicas. 20 especies fructificaron sólo una vez; las más frecuentes fueron Amanita flavoconia var. inquinata , A. flavoconia var. flavoconia, A. flavoconia var. sinapicolor, A. virosa, A. xylinivolva, A .muscaria var. flavivolvata y A. arocheae. Los resultados muestran la necesidad de continuar los estudios en la comunidad de Ixtlán donde especies poco frecuentes de Amanita y otros datos ecológicos podrán conocerse.The diversity of Amanita species occurring in two areas of Pinus-Quercus forest with different management, in the community of Ixtlán de Juárez, Oaxaca, was studied. The samples were collected during the wet season. The 107 specimens collected correspond to 36 species, 21 belonging to the subgenus Amanita and 15 to the subgenus Lepidella; 14 represent first records in Oaxaca state and 19 to Ixtlán of Juarez County in particular. The abundance of species within a year was correlated with the precipitation and ecological conditions. Twenty species appeared once and the most frequent were: Amanita flavoconia var. sinapicolor, A. flavoconia var. flavoconia, A. virosa, A. flavoconia var. inquinata, A. xylinivolva, A .muscaria var. flavivolvata y A. arocheae. These findings encourage for further studies in the community of Ixtlán, where infrequent species of Amanita and other ecological data may be obtained.

  9. On the Phenomenon of Poetizing by Self-Comment in Du Fu' s Poems%论杜诗中自陈作诗的现象

    Institute of Scientific and Technical Information of China (English)

    查正贤

    2012-01-01

    In some of his poems, Du Fu liked to talk about poetizing by self-comment. This way of writing stemmed from some works in The Book of Songs, at the beginning or the end of which the authors indicated why they sang the song. This specific tradition and the learning of this way of writing gradually formed a sort of poetic art to express emotions and describe scenes, which promoted the emergence of Du Fu' s poetic creation. Du Fu' s poetic creation was a result of his devotion to exploring poetic art when he stayed alone, which made a significant influence on the history of poetry. Du Fu' s activities of poetizing by self-comment were also based on his poetic creation. Du Fu had his poems created when he was experiencing the inner-self and the outside world. As a result, Du Fu formed a unique view about poets and poems, and he definitely differed himself from other poets in the Tang Dynasty in relation to the poetic form and logical argument.%杜甫有一些在诗歌中自述“作诗”的作品,这源于对《诗经》中一些作品在首尾点出赋诗本意之法的学习,而发展成为一种特定的缘情体物的诗艺,并推动了杜诗中以诗歌创作活动为题材的现象的出现。这是杜甫在穷途独处的人生中探索诗艺的结果,不但有重要的诗歌史意义,而且也是他以诗论诗的活动产生的背景。这些论诗之作孕育于其赋诗遣怀的创作过程之中,首先也还是他的体物缘情的产物。这一性质决定了杜甫对诗歌与诗人的评论在形式和立论方式上都与唐人常见的方式有着较大的不同。

  10. 羟基喜树碱联合5Fu/CF治疗晚期大肠癌临床研究%Clinical study on HCPT combined with 5Fu/CF chemotherapy in treating patients with advanced colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    段家华; 王继红; 霍丹

    2005-01-01

    目的观察应用羟基喜树碱联合5Fu/CF化疗治疗晚期大肠癌的近期疗效及不良反应.方法将24例晚期大肠癌随机分为两组.治疗组:羟基喜树碱(HCPT)8mg/m2 iv.d1~5,甲酰四氢叶酸钙200mg iv d1~5,5-氟尿嘧啶500mg/m2 iv d1~5,对照组:5F+CF用法用量同治疗组.以上方案每四周重复.结果治疗组有效率41.6%,对照组有效率33.3%,主要不良反应为消化系统,血液系统,多为Ⅰ、Ⅱ度,患者耐受好.结论HCPT联合方案治疗晚期大肠癌安全有效,值得临床进一步观察研究.

  11. O realismo jurídico como pragmatismo: a retórica da tese realista de que direito é o que os juízes dizem que é direito

    OpenAIRE

    de Melo Freitas, Lorena

    2009-01-01

    A tese tem como tema o realismo jurídico norte-americano. Defende-se que esta corrente se insere no pensamento jurídico como representante do pragmatismo filosófico ao considerar que direito é o que os juízes dizem que é direito. Esta tese do realismo é o objeto de estudo no presente trabalho a ser estudado com o recurso metodológico da retórica. Por meio da retórica material ou existencial se identificará o ambiente do Clube metafísico de Boston com vistas a se investigar a...

  12. Programa de capacitación laboral en producción y emprendedurismo agroecológico en el Municipio de Estación Juárez Celman, Córdoba

    OpenAIRE

    2015-01-01

    En el marco de un acuerdo de cooperación entre INTA – Pro Huerta y el Municipio Estación Juárez Celman (EJC) se inicia una experiencia piloto en diciembre de 2014 con programas de entrenamientos laborales del Ministerio de Trabajo de la Nación. En el primer curso se capacitaron a 36 jóvenes con interés en iniciar un emprendimiento propio de producción agroecológica (alimentos frescos, conservas, panificación o pastas, lombri-compuestos, flores y jardinería, servicios, entre otros). Consta de:...

  13. Redes empresariales en el sector turismo y servicios para la mejora de competitividad en Ciudad Juárez, Chihuahua, México: caso Parque Central Hermanos Escobar y PYMES aledañas

    OpenAIRE

    2016-01-01

    La presente investigación, muestra la cooperación y relación que existe entre las pequeñas y medianas empresas (Pymes) del sector turismo y servicios circunvecinos al Parque Central Hermanos Escobar (PCHE) en Ciudad Juárez, Chihuahua (CJS), y su colaboración con este último. Se destacan las relaciones derivadas entre empresas y actores de la zona bajo el marco de la competitividad. En los resultados se presenta la red informal existente, así como la red que se generaría si estas empr...

  14. On the Association of Song Yu's Fu with Fu of Han Dynasty on Their Spatial Narration——With the Analysis on the Types and Characteristics of Spatial Narration in Fu of Han Dynasty%宋玉辞赋与汉代散体大赋空间叙事的关联——兼论汉赋空间叙事的类型及其特征

    Institute of Scientific and Technical Information of China (English)

    彭安湘

    2016-01-01

    Song Yu played an important role in the transformation process of Chuci to Fu. Song Yu's works are closely related with Fu in Han dynasty on the following aspects: the extreme and growingly detailed numeration, the special idea and the three-dimensional space system embodied in the narration of Fu. The Fu writers in Han dynasty pushed the space narration to its maturity by combining the spatial ideas in ancient works and using the writing techniques of previous works. The space narration can be mainly classified into three types: position narration, class narration, and shift narration. The characteristics of space narration are as follows: the interdependence of space narration and time narration, the combination of realistic writing and fiction, the collaboration of surface structure and spatial idea.%宋玉在由楚辞到汉赋的文体转换过程中起到了重要的作用,尤其是其辞赋作品建构的立体空间坐标系,以及逐次相加的极度铺排、渲染所体现出的空间观念、"空间图式"成为与汉代散体大赋关联的新角度.汉赋作家综合古代空间意识及前代作品的创作经验进一步将空间叙事推向成熟.汉赋空间叙事主要有空间方位叙事、空间"连类"叙事和空间移位叙事三种主要类型,并具有空间叙事与时间叙事互为依存、征实与虚构互为补充以及表层结构与空间意义互为支撑等鲜明特征.

  15. YiQiFuMai Powder Injection Ameliorates Cerebral Ischemia by Inhibiting Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis

    Directory of Open Access Journals (Sweden)

    Guosheng Cao

    2016-01-01

    Full Text Available YiQiFuMai (YQFM powder injection as a modern preparation derived from Sheng Mai San, a traditional Chinese medicine, has been widely used in the treatment of cardiovascular and cerebrovascular diseases. However, its neuroprotective effect and underlying mechanism in cerebral ischemia remain to be explored. The present study was designed to investigate the neuroprotective effect of YQFM on endoplasmic reticulum (ER stress-mediated neuronal apoptosis in the permanent middle cerebral artery occlusion- (MCAO- injured mice and the oxygen-glucose deprivation- (OGD- induced pheochromocytoma (PC12 cells. The results showed that single administration of YQFM (1.342 g/kg, i.p. could reduce the brain infarction and improve the neurological deficits and the cerebral blood flow (CBF after MCAO for 24 h in mice. Moreover, incubation with YQFM (100, 200, and 400 μg/mL could increase the cell viability, decrease the caspase-3 activity, and inhibit the cell apoptosis in OGD-induced PC12 cells for 12 h. In addition, YQFM treatment could significantly modulate cleaved caspase-3 and Bcl-2 expressions and inhibit the expressions of ER stress-related marker proteins and signaling pathways in vivo and in vitro. In conclusion, our findings provide the first evidence that YQFM ameliorates cerebral ischemic injury linked with modulating ER stress-related signaling pathways, which provided some new insights for its prevention and treatment of cerebral ischemia diseases.

  16. A randomized controlled trial of Kung Fu training for metabolic health in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2009-07-01

    Twenty overweight/obese adolescents underwent six months of Kung Fu or placebo (Tai Chi) training, 3x.wk(-1). Outcomes included fasting insulin and insulin resistance, lipids, glucose and HbA(1c), and C-reactive protein (CRP). CRP decreased significantly (p = 0.03) in both groups over time at six months. Although insulin sensitivity did not change, HbA(1c) tended to decrease over time (p = 0.09), again with no group difference (p = 0.60). Reduced CRP was related to increased upper body strength (p = 0.01). Increased lean body mass was related to reductions in HbA(1c), insulin resistance, triglycerides, and total cholesterol. Improvements in lean body mass appear to have a potential role in favorable metabolic outcomes, independent of changes in fat mass. Further research in this area is warranted before definite conclusions can be drawn about the efficacy of martial arts training for metabolic outcomes in this cohort.

  17. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Science.gov (United States)

    Tsang, Tracey W.; Kohn, Michael R.; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 ± 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37–2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness. PMID:20798764

  18. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Directory of Open Access Journals (Sweden)

    Tracey W. Tsang

    2010-01-01

    Full Text Available Aim. To examine the efficacy of a six-month Kung Fu (KF program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7±27.8%. At follow-up, the cohort improved in absolute upper (P=.002 and lower (P=.04 body strength, and upper body muscle endurance (P=.02, without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P=.03, lower body muscle endurance (P=.28; significant 95% CI: 0.37–2.49, and upper body muscle velocity (P=.03 relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  19. The large amplitude outburst of the young star HBC 722 in NGC 7000/IC 5070, a new FU Orionis candidate

    CERN Document Server

    Semkov, E; Munari, U; Milani, A; Valisa, P

    2010-01-01

    We report the discovery of a large amplitude outburst from the young star HBC 722 (LkHA 188 G4) located in the region of NGC 7000/IC 5070. On the basis of photometric and spectroscopic observations, we argue that this outburst is of the FU Orionis type. We gathered photometric and spectroscopic observations of the object both in the pre-outburst state and during a phase of increase in its brightness. The photometric BVRI data (Johnson-Cousins system) that we present were collected from April 2009 to September 2010. To facilitate transformation from instrumental measurements to the standard system, fifteen comparison stars in the field of HBC 722 were calibrated in the BVRI bands. Optical spectra of HBC 722 were obtained with the 1.3-m telescope of Skinakas Observatory (Crete, Greece) and the 0.6-m telescope of Schiaparelli Observatory in Varese (Italy). The pre-outburst photometric and spectroscopic observations of HBC 722 show both low amplitude photometric variations and an emission-line spectrum typical of...

  20. ELECTROMYOGRAPHIC STUDY OF A SEQUENCE OF YAU-MAN KUNG FU PALM STRIKES WITH AND WITHOUT IMPACT

    Directory of Open Access Journals (Sweden)

    Osmar Pinto Neto

    2007-10-01

    Full Text Available In martial arts and contact sports, strikes are often trained in two different ways: with and without impacts. This study aims to compare the electromyographical activity (EMG of the triceps brachii (TB, biceps brachii (BB and brachioradialis (BR muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms and frequency (wavelet domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar

  1. 富厚堂藏书目录浅析%Analysis of Bibliography of Fu Hou Tang

    Institute of Scientific and Technical Information of China (English)

    刘金元

    2012-01-01

    富厚堂藏书目录有很多特点,书楼第一代主人曾国藩著录的《京师书目》与《利见斋书目》信息详细;《求缺斋书目》与《公记书目》反映出其馆藏特色;《归朴斋书目》与《艺芳馆书目》则突出其藏为实用的特点。这些书目虽没有完全反映出富厚堂的馆藏,但为后人了解富厚堂馆藏及其藏书背景提供了重要参考。%Bibliography of Fu Hou Tang has many characteristics . The first master of building Tseng Kuofan recorded " Bibliography of Capital" and "Bibliography of Jian Lizhai", which are detail in information; "Bibliography of Qiu Quezhai" and " Public Bibliography" reflect abundant collections of the building; "Bibliography of Gni Puzhai" and "Bibliography of Yifang Museum" stress the characteristic of science and technology. These title catalogues become significant reference basis for the future generation to understand the background of masters collecting books and collections.

  2. Atmospheric Phase Correction using CARMA-PACS: High Angular Resolution Observations of the FU-Orionis star PP 13S*

    CERN Document Server

    Pérez, Laura M; Woody, David P; Carpenter, John M; Zauderer, B Ashley; Isella, Andrea; Bock, Douglas C; Bolatto, Alberto D; Carlstrom, John; Culverhouse, Thomas L; Joy, Marshall; Kwon, Woojin; Leitch, Erik M; Marrone, Daniel P; Muchovej, Stephen J; Plambeck, Richard L; Scott, Stephen L; Teuben, Peter J; Wright, Melvyn C H

    2010-01-01

    We present 0.15" resolution observations of the 227 GHz continuum emission from the circumstellar disk around the FU-Orionis star PP 13S*. The data were obtained with the Combined Array for Research in Millimeter-wave Astronomy (CARMA) Paired Antenna Calibration System (C-PACS), which measures and corrects the atmospheric delay fluctuations on the longest baselines of the array in order to improve the sensitivity and angular resolution of the observations. A description of the C-PACS technique and the data reduction procedures are presented. C-PACS was applied to CARMA observations of PP 13S*, which led to a factor of 1.6 increase in the observed peak flux of the source, a 36% reduction in the noise of the image, and a 52% decrease in the measured size of the source major axis. The calibrated complex visibilities were fitted with a theoretical disk model to constrain the disk surface density. The total disk mass from the best fit model corresponds to 0.06 \\msun, which is larger than the median mass of a disk ...

  3. Gauge-theoretic invariants for topological insulators: A bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    CERN Document Server

    Monaco, Domenico

    2016-01-01

    We establish a connection between two recently-proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant $\\mathrm{FKM} \\in \\mathbb{Z}_2$, arising in the context of 2-dimensional time-reversal symmetric topological insulators. On the one hand, the $\\mathbb{Z}_2$ invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes it is possible to provide an expression for $\\mathrm{FKM}$ containing the square root of the Wess-Zumino amplitude for a certain $U(N)$-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields $\\mathbb{T}^2 \\to U(N)$, of which we provide a p...

  4. Sensitivity Analysis on Fu-Liou-Gu Radiative Transfer Model for different lidar aerosol and cloud profiles

    Science.gov (United States)

    Lolli, Simone; Madonna, Fabio; Rosoldi, Marco; Pappalardo, Gelsomina; Welton, Ellsworth J.

    2016-04-01

    The aerosol and cloud impact on climate change is evaluated in terms of enhancement or reduction of the radiative energy, or heat, available in the atmosphere and at the Earth's surface, from the surface (SFC) to the Top Of the Atmosphere (TOA) covering a spectral range from the UV (extraterrestrial shortwave solar radiation) to the far-IR (outgoing terrestrial longwave radiation). Systematic Lidar network measurements from permanent observational sites across the globe are available from the beginning of this current millennium. From the retrieved lidar atmospheric extinction profiles, inputted in the Fu-Liou-Gu (FLG) Radiative Transfer code, it is possible to evaluate the net radiative effect and heating rate of the different aerosol species and clouds. Nevertheless, the lidar instruments may use different techniques (elastic lidar, Raman lidar, multi-wavelength lidar, etc) that translate into uncertainty of the lidar extinction retrieval. The goal of this study is to assess, applying a MonteCarlo technique and the FLG Radiative Transfer model, the sensitivity in calculating the net radiative effect and heating rate of aerosols and clouds for the different lidar techniques, using both synthetic and real lidar data. This sensitivity study is the first step to implement an automatic algorithm to retrieve the net radiative forcing effect of aerosols and clouds from the long records of aerosol measurements available in the frame of EARLINET and MPLNET lidar networks.

  5. I Am the Invincible Sword Goddess: Mediatization of Chinese Gender Ideology through Female Kung-Fu Practitioners in Films

    Directory of Open Access Journals (Sweden)

    Mie Hiramoto

    2014-09-01

    Full Text Available The media are avid portrayers of gender binarism and the belief in male-female distinctions, which are mainly attributed to perceived differences of a physical nature. In this paper, we investigate representations of female kung-fu practitioners (nuxia in films to discuss how processes of mediation and mediatization depict their femininity, so as to mitigate their appropriation of Chinese martial arts masculinity. Often, nuxias are portrayed as empowered women who are equipped to take control of their own lives and to courageously take on challenges from a variety of opponents. However, multimodal deconstruction of the various characteristics of nuxias must be placed in an Asian-specific context in order to understand the femininity specific to these characters and to move beyond Western gender ideologies displayed by the media. Perpetuating Confucian patriarchal ideals, nuxia roles constantly and consistently associate conformation to Confucian values with virtuousness and non-conformation with wickedness. We therefore can use the ideals of Confucianism as a more accurate foundation in deconstructing the identities of nuxias, which allows us to better understand the mediation and mediatization processes of ideologies associated with Chinese femininity and masculinity in martial arts films.

  6. «A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939

    Directory of Open Access Journals (Sweden)

    Matilde Cartolari

    2016-12-01

    Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

  7. VARIABILITY AT THE EDGE: OPTICAL NEAR/IR RAPID-CADENCE MONITORING OF NEWLY OUTBURSTING FU ORIONIS OBJECT HBC 722

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Robertson, Paul; Pak, Soojong; Meschiari, Stefano [Department of Astronomy, 2515 Speedway, University of Texas at Austin, Austin, TX (United States); Baek, Giseon; Lee, Jeong-Eun [School of Space Research, Kyung Hee University, Gyeonggi-Do 446-741 (Korea, Republic of); Pooley, David [Department of Physics, Sam Houston State University, Huntsville, TX (United States); Im, Myungshin; Jeon, Yiseul; Choi, Changsu [CEOU/Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of)

    2013-02-10

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from >42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1 m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8-day (0.044 mag amplitude) and 1.28-day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random 'flickering', magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming that the 5.8-day period is due to stellar rotation and the 1.28-day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R {sub *}), we derive a B-field strength of 2.2-2.7 kG, slightly larger than typical T Tauri stars. If instead the 5.8-day signal is from a disk asymmetry, the instability region has an outer radius of 5.4 R {sub *}, consistent with models of FUor disks. Further exploration of the time domain in this complicated source and related objects will be key to understanding accretion processes.

  8. Variability at the Edge: Optical Near/IR Rapid Cadence Monitoring of Newly Outbursting FU Orionis Object HBC 722

    CERN Document Server

    Green, Joel D; Baek, Giseon; Pooley, David; Pak, Soojong; Im, Myungshin; Lee, Jeong-Eun; Jeon, Yiseul; Choi, Changsu; Meschiari, Stefano

    2012-01-01

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from > 42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8 day (0.044 mag amplitude) and 1.28 day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random "flickering", magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming the 5.8 day period is due to stellar rotation and the 1.28 day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R(star)), we derive a B-field strength of 2.2-2.7 kG, slightly ...

  9. Technical note: Fu-Liou-Gu and Corti-Peter model performance evaluation for radiative retrievals from cirrus clouds

    Science.gov (United States)

    Lolli, Simone; Campbell, James R.; Lewis, Jasper R.; Gu, Yu; Welton, Ellsworth J.

    2017-06-01

    We compare, for the first time, the performance of a simplified atmospheric radiative transfer algorithm package, the Corti-Peter (CP) model, versus the more complex Fu-Liou-Gu (FLG) model, for resolving top-of-the-atmosphere radiative forcing characteristics from single-layer cirrus clouds obtained from the NASA Micro-Pulse Lidar Network database in 2010 and 2011 at Singapore and in Greenbelt, Maryland, USA, in 2012. Specifically, CP simplifies calculation of both clear-sky longwave and shortwave radiation through regression analysis applied to radiative calculations, which contributes significantly to differences between the two. The results of the intercomparison show that differences in annual net top-of-the-atmosphere (TOA) cloud radiative forcing can reach 65 %. This is particularly true when land surface temperatures are warmer than 288 K, where the CP regression analysis becomes less accurate. CP proves useful for first-order estimates of TOA cirrus cloud forcing, but may not be suitable for quantitative accuracy, including the absolute sign of cirrus cloud daytime TOA forcing that can readily oscillate around zero globally.

  10. Protective effect of the extract of Yi-Qi-Fu-Mai preparation on hypoxia-induced heart injury in mice

    Institute of Scientific and Technical Information of China (English)

    FENG Ya-Qian; JU Ai-Chun; LIU Chun-Hua; WANG Ting; YU Bo-Yang; QI Jin

    2016-01-01

    Yi-Qi-Fu-Mai (YQFM) is extensively used clinically to treat cardiovascular diseases in China.To explore the anti-hypoxia effect of the extract of YQFM preparation (EYQFM),the EYQFM (1.4,2.8,and 5.5 g·kg-1·d-1) was assessed for its heart-protective effect in a chronic intermittent hypoxia (CIH) animal model (oxygen pressure 7%-8%,20 min per day) for 28 days of treatment.Betaloc (0.151 6 g·kg-1·d-1) was used as a positive control.The histopathological analyses of heart in CIH mice were conducted.Several cardiac state parameters,such as left ventricular ejection fractions (EF),stroke volume (SV),expression of creatine kinase (CK),lactate dehydrogenase (LDH),superoxide dismutase (SOD),and malondialdehyde (MDA) were measured.The results showed that treatment with EYQFM markedly reversed swelling of the endothelial cells and vacuolization in the heart when compared with the model group.Further study demonstrated that EYQFM significantly improved ventricular myocardial contractility by increasing EF and SV.In addition,EYQFM inhibited the activity of CK,LDH,decreased the level of MDA and improved SOD activity.The results demonstrated that EYQFM significantly improved the tolerability of myocardium to hypoxia and ameliorated the cardiac damage in the CIH model.

  11. Introduction to Baoz hao’ s Emotions in His Fu%浅谈鲍照赋的思想情感

    Institute of Scientific and Technical Information of China (English)

    陈刚

    2014-01-01

    Because of Bao Zhao’s special life experience and his inheritance of Fu in Wei and Jin Dynasties ,the theme of his Fu’s is basical-ly around releasing the pathos ,which contains both the bleak and anxious emotions with ambitious but unachievable aims ,as well as the subli-mated ,gorgeous and affecting writing style ,showing a high degree of combination of rhetoric and emotion then demonstrating a unique look in the transition of Fu’s creation from Wei and Jin Dynasties to the Southern Dynasties .%由于鲍照特殊的身世经历和他对魏晋赋的继承接受,鲍照赋的思想情感基本围绕宣泄悲情而展开,既包含苍壮急怨、清拔阔大的情感特质,又显得奇崛伟丽、藻艳精工、倾炫心魄,表现出辞、情的高度统一,在辞赋创作由魏晋向南朝的过渡中呈现了一种独特的面貌。

  12. Gauge-theoretic invariants for topological insulators: a bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    Science.gov (United States)

    Monaco, Domenico; Tauber, Clément

    2017-02-01

    We establish a connection between two recently proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant FKMin Z_2 , arising in the context of two-dimensional time-reversal symmetric topological insulators. On the one hand, the Z_2 invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes, it is possible to provide an expression for FKM containing the square root of the Wess-Zumino amplitude for a certain U(N)-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above-mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields T^2 → U(N) , of which we provide a proof employing only basic homotopy theory and circumventing the language of bundle gerbes.

  13. [Trial of home anti-cancer chemotherapy with infusion of 5-FU and low-dose cisplatin].

    Science.gov (United States)

    Muto, A; Ashino, Y; Ito, H; Kanno, A; Moriyama, A; Hiraga, M

    1996-12-01

    We tried home anti-cancer chemotherapy for patients with advanced or recurrent cancer of the digestive system, using two disposable balloon pumps connected to an implantable drug delivery system via central venous line. There were 33 patients under 75 years old, including 20 cases of gastric cancer, 9 cases of colorectal cancer, 2 cases of cholangiocarcinoma and 2 cases of esophageal cancer enrolled in this study. The protocol was combined chemotherapy with continuous intravenous infusion of 5-FU (300 mg/body/day) and low-dose intravenous injection of cisplatin (5 mg/body/day) in 10-day courses for two weeks, and it was repeated 3 times for 6 weeks. Because of side effects such as nausea, vomiting and bone marrow suppression, treatment was discontinued in 12 cases with peritoneal cancer infiltration. In two of 10 with estimable disease, the reduction of the metastatic lymph node was observed, but no effect was shown in the colorectal metastatic liver tumor. Thanks to the portability of the pump with this method, the patient need not undergo hospitalization. Moreover, there is no renal dysfunction or other major side effects, quality of life is not compromised and a return to family and social life is possible. Thus, if the patient cannot take the oral nutrition, it is easy to start home hyper-alimentation.

  14. Scaling of the Sheared-Flow Stabilized Z-Pinch: The Fusion Z-Pinch Experiment ``FuZE''

    Science.gov (United States)

    Nelson, B. A.; Shumlak, U.; Claveau, E. L.; Golingo, R. P.; Weber, T. R.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Collaboration

    2016-10-01

    The sheared flow stabilized (SFS) Z-pinch ZaP experiment was constructed based on calculations [1] showing stabilization of kink and sausage instabilities. ZaP experimentally demonstrated production and sustainment of an SFS Z-pinch for a wide range of plasma parameters, with densities up to n =1023 m-3 and a pinch radius of a = 1 cm. [2-4] The SFS Z-pinch is resistant to the instabilities of conventional Z-pinches, yet maintains the same favorable radial scaling, making it an energy-efficient way to achieve fusion-relevant conditions. The ZaP-HD (high density) experiment has demonstrated scaling of the SFS Z-pinch to 2-3 × smaller a and 10 × higher n. [5] Supported by ZaP and ZaP-HD, the Fusion Z-pinch Experiment (FuZE) project investigates scaling plasma parameters toward fusion conditions by decreasing a 2-3 × to 1 mm, and increasing n 10 × to 1025 m-3. The approach combines improved gas injection and flexible power supplies with the successful ZaP SFS Z-pinch formation. Detailed fluid and kinetic simulations complement the experimental studies to gain scientific insight into the plasma behavior and predict scaling to higher performance. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

  15. In vivo experimental testing of the FW axial blood pump for left ventricular support in Fu Wai Hospital.

    Science.gov (United States)

    Zhang, Yan; Hu, Sheng-Shou; Zhou, Jian-Ye; Sun, Han-Song; Tang, Yue; Zhang, Hao; Zheng, Zhe; Li, Guo-Rong; Zhu, Xiao-Dong; Gui, Xin-Min

    2009-01-01

    A fully implantable, axial flow blood pump has been developed in Fu Wai Hospital aiming for clinical use. This ventricular assist device (VAD), which was developed after numerous CFD analyses for the flow characteristics of the pump, is 58.5-mm long, 30-mm wide (including DC motor), and weighs 240 g. The pump can deliver 5 L/min for pressures of 100 mm Hg over 8,000 rpm. In this study, short-term hemocompatibility effects of the axial left ventricular assist device (LVAD) (FW blood pump) were evaluated in four healthy sheep. The device was implanted into the left ventricular apex of beating hearts. The outflow graft of each device was anastomosed to the descending aorta. The hemolysis, which was evaluated in vivo by free hemoglobin value, was below 30 mg/dL. Evaluation of serum biochemical data showed that implantation of the FW blood pump in sheep with normal hearts did not impair end organ function. Gross and microscopic sections of kidney, liver, and lung revealed no evidence of microemboli. Performance of the pump in vivo was considered sufficient for a LVAD, although further design improvement is necessary in terms of hemolysis and antithrombosis to improve biocompatibility of the pump.

  16. 《文选》中哀伤赋以及选录标准%Grief Fu in"The Selection of Literary Works"and Selecting Criteria

    Institute of Scientific and Technical Information of China (English)

    郭家嵘

    2014-01-01

    魏晋南北朝中弥漫着哀怨伤感的气息,《文选》中的哀伤赋正是这乱世文人在作品中的宣泄呐喊,作者巧妙地运用抒情小赋特有的铺陈手法,再现了六朝黑暗狡诈的社会现实以及文人沉浮其中的感情内涵。%It was filled with sorrow and sadness in the Wei ,Jin ,Northern and Southern Dynasties ,so the grief Fu in"The Selection of Literary Works"was the literators'catharsis and cry in this trouble time .The author skillfully used the elaborated method that lyrical Fu peculiarly had to reproduce dark cunning social reality of Six Dynasties and the literators'emotion connotation .

  17. 从脏腑论治泄泻探源%Explore the origin of Zang-fu syndrome differentiation and treatment of diarrhea

    Institute of Scientific and Technical Information of China (English)

    康洪昌; 周正华

    2013-01-01

    Through the combing TCM literature about diarrhoea,this article to analyze relationship between the occurrence of diarrhoea and Zang-fu. For correct diagnosis and treatment diarrhoea to provide helpless, we explore the historical origin and development of Zang-fu syndrome differentiation and treatment of diarrhea. The results showed that although the spleen and stomach is the foundation of diarrhea,but all the viscera can lead to the occurrence of diarrhea.%通过梳理古代文献关于泄泻的论述,分析了泄泻的发生与各脏腑的关系,探讨“脏腑论泄”的历史源流,为正确辨证论治泄泻提供裨助.结果发现虽云“泄泻之本,无不由于脾胃”,但五脏六腑皆令人泻,非独脾胃也.

  18. Modelado de las Distribuciones Espectrales de Energía de tres nuevas estrellas jóvenes de tipo FU Orionis

    Science.gov (United States)

    Gramajo, L. V.; Rodón, J.; Gómez, M.; Whitney, B.

    In this work we present the modeling of the spectral energy distributions (SEDs) of three protostellar objects of the FU Orionis type, for which an outburst was observed in the last two years. We applied the code developed by Whitney et al. (ApJ 591, 1049, 2003) to model the SEDs. We derived physical and geometric parameters for each object, which agree with those previously obtained for other FU Orionis type stars. Furthermore, the three objects were studied in their stages of high and low activity. Our results suggest that the disk plays a key role in the outburst event, which is reflected in an increase of at least one order of magnitude of the mass accretion rate from the disk to the central object, with respect to the low activity period. FULL TEXT IN SPANISH

  19. Review of dissertation The Association Of Intelligence, Visual-Motor Functioning, And Personality Characteristics With Adaptive Behavior In Individuals With Williams Syndrome by Juhsin Trista Fu

    Directory of Open Access Journals (Sweden)

    Florova N.B.

    2015-06-01

    Full Text Available Juhsin Trista Fu (Taiwan is an American clinical psychologist, doctor of philosophy (PhD, on the national register of health professionals of United States National Provider Identifiers (NPI Registry. The proposed material gives a systematic description of the dynamics of specific behavioral construct in adults in situation of genetic anomalies. The author regards this condition as a volatile state which to a certain extent responds to interventions.

  20. A Review of Chinese Fu Study in the End of the 20th Century%20世纪末期中国赋学述评

    Institute of Scientific and Technical Information of China (English)

    徐志啸

    2013-01-01

      20世纪80年代初至世纪末约20年左右的时间,是中国赋学史上赋学研究的高峰期和多产期。这一时期,因着改革开放的社会和时代因素,赋学研究呈现出了学者不断涌现、成果丰硕喜人的景象,赋在文学史研究领域也开始和其他文体一样,被置于相当的地位,予以尽可能客观的研究,且这种研究是在传统赋学基础上展开进行的,因而更趋于科学化和理性化。%From the early 1980s to the end of the 20th century, it is a productive peak period in the history of Chinese Fu study. At that time, thanks to the reform and opening-up policy and the advantageous social circumstances, Fu study underwent a pros-perous development, bringing about many scholars and fruitful achievements.Like other genres, Fu was properly positioned in the research field of literary history and its study received an objective treatment.Since the research was based on traditional Fu study, it was more scientific and rational.

  1. A trio of gamma-ray burst supernovae:. GRB 120729A, GRB 130215A/SN 2013ez, and GRB 130831A/SN 2013fu

    NARCIS (Netherlands)

    Cano, Z.; et al., [Unknown; Hartoog, O.

    2014-01-01

    We present optical and near-infrared (NIR) photometry for three gamma-ray burst supernovae (GRB-SNe): GRB 120729A, GRB 130215A/SN 2013ez, and GRB 130831A/SN 2013fu. For GRB 130215A/SN 2013ez, we also present optical spectroscopy at t − t0 = 16.1 d, which covers rest-frame 3000-6250 Å. Based on Fe ii

  2. A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma.

    Science.gov (United States)

    Gennatas, C; Papaxoinis, G; Michalaki, V; Mouratidou, D; Andreadis, C; Tsavaris, N; Pafiti, A

    2006-10-01

    The purpose of this study was to compare the activity and toxicity of an irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) combination with a standard regimen of 5FU and LV, in patients with advanced colorectal carcinoma. One hundred and sixty patients were randomized; 80 patients (group A) received LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1-5, every 28 days; 80 patients (group B) received CPT-11 80 mg/m(2) (30-90 min i.v. infusion), followed by LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1, 8, 15, 22, 29, and 36, every 8 weeks. The overall response rate was 30% and 47.5% in groups A and B respectively. Progression-free survival was significantly higher in the triple-drug combination arm (median 7.5 vs. 4.5 months; p= 0. 0335). However, overall survival did not differ significantly between the two arms (15 months vs. 14 months for the groups B and A respectively; p=0.3531). The main grade 3 adverse events were diarrhea (19%, in group A vs. 35% in group B; p=0.032) and mucositis (2% vs. 14%; p=0.017). The regimen containing irinotecan showed activity in advanced colorectal cancer. The overall safety data confirm this combination as a well-tolerated treatment.

  3. A pilot study of first-line chemotherapy with 5-FU and Platinum in advanced and recurrent cancer of the cervix

    Directory of Open Access Journals (Sweden)

    Ghaemmaghami F

    2003-06-01

    Full Text Available This study was designed to assess the role of first-line chemotherapy with 5-FU and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase II trial, from Oct. 2000 to Nov. 2001. Eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day followed by 5-FU (1 g/m2 over 24 hours for 4 days and two patients with impaired renal function were treated with carboplatin (300 mg/m2 over 15 minutes in first day followed by 5-FU (1 g/m2 over 24 hours for 4 days every three weeks, until progression of disease or prohibitive toxicity had been observed. Median age was 52 years (range: 28-70 years. Ten patients received a total of 42 cycles of chemotherapy. The mean number of chemotherapy cycles was 4.2 (median 4, range: 3-7. Three patients had partial response (30%, CI, 1.7%-58.5%. Mean response duration was 198 days (range: 122-273 days. Four patients required red blood cell transfusions; three of them had grade II and one of them grade III nausea and vomiting Two had fever and neutropenia (one developed acute renal insufficiency, and there wee no treatment related mortalities. First-line chemotherapy with platinum and 5-FU for advanced recurrent cervical cancer is promising and deserves consideration for large phase III trials.

  4. Estrategias y campañas de desinformación gubernamental y manipulación informativa en relación a los feminicidios y secuestros de mujeres y niñas en Ciudad Juárez entre 1993 y 2013

    OpenAIRE

    Juárez Rodríguez, Javier

    2016-01-01

    El presente trabajo es el resultado de la labor investigativa llevada a cabo para analizar desde una perspectiva científica los mensajes y las acciones desarrolladas por el Gobierno mexicano, los medios de comunicación y las asociaciones defensoras de los derechos humanos en relación a los casos de violencia contra mujeres y niñas en Ciudad Juárez (México). La investigación tiene entre sus objetivos aportar un análisis actualizado sobre la situación real que sufren las mujeres en Ciudad Juár...

  5. Un programa de fertilización sustentable para el Ingenio "Presidente Benito Juárez" en Tabasco, México

    Directory of Open Access Journals (Sweden)

    S. Salgado-García

    2011-01-01

    Full Text Available Las dosis de fertilización y sitio específicos para el cultivo de caña de azúcar en el área de abastecimiento del Ingenio "Presidente Benito Juárez" (Ipbj no habían sido precisados, sin embargo, el alto costo de los fertilizantes químicos y la necesidad de reducir la contaminación del ambiente obligan a optimizar su uso. A fin de precisar dosis de fertilización adecuadas para dicha área, este trabajo emplea la metodología del "Sistema Integrado para Recomendar Dosis de Fertilizantes", tomando en cuenta las características de los suelos y el rendimiento potencial. Como parte de este estudio, se identificaron las subunidades de suelo mediante interpretación de fotografías aéreas, reconocimientos de campo y muestreos (-1.20 m en el área de influencia del Ipbj (92,973 ha. En cada unidad se describieron perfiles agrológicos y se hicieron análisis físico-químicos para clasificar los suelos, según el Referencial Mundial de Suelos (wrb. Los resultados generaron cinco polígonos de Thiessen, con precipitaciones anuales entre 1,640 a 2,227 mm. Se determinó una dosis de fertilización npk para cada subunidad de suelo, usando el modelo conceptual de balance entre demanda del nutrimento, el suministro y la eficiencia del fertilizante aplicado. Las dosis de fertilización ajustadas son (N, P2O5, K2O kg/ha, 120-60-60 para los suelos Cambisolesflúvicos, endogléyicos y estágnicos, 120-70-80 para Cambisoles y Gleysoles; 160-80-80 para Vertisoles gléyico-estágnicos, 120-80-80 para Vertisoles estágnico-éutricos. Además, se generó un mapa de fertilización específico para el área de abasto del Ipbj, a escala 1:40 000.

  6. Magnetism of Minor Bodies in the Solar System: From 433 Eros, passing Braille, Steins, and Lutetia towards Churyumov-Gerasimenko and 1999 JU3.

    Science.gov (United States)

    Hercik, David; Auster, Hans-Ulrich; Heinisch, Philip; Richter, Ingo; Glassmeier, Karl-Heinz

    2015-04-01

    observations the next ideal candidate mission is Hayabusa-II with its Mascot lander equipped with fluxgate magnetometer. The small-sized lander shall deliver the magnetometer within centimeters from the surface, providing measurements on multiple points thanks to a hopping ability. The mission has been recently launched (December 2014) and is aiming to a C-type asteroid 1999 JU3 to reach it in 2018. The results will hopefully add some piece of information to the still unclear question of minor solar system bodies magnetization.

  7. GC FU ji IX玻璃离子及银粉玻璃离子充填乳磨牙龋齿的疗效观察%Efficacy of GC FU ji IX glass ionomer and silver glass ionomer filling dental caries in deciduous molars

    Institute of Scientific and Technical Information of China (English)

    刘军

    2010-01-01

    目的 比较GC FU ji IX玻璃离子和银粉玻璃离子在乳磨牙龋齿充填中的临床效果.方法 选择72个病例144颗患牙,采用自身对照,一颗乳磨牙用GC FU ji IX玻璃离子充填,同名另一颗用银粉玻璃离子充填,半年、1年后分别复查.结果 半年复查,两组成功率无统计学差异(P>0.05);1年比较,GC FU ji IX玻璃离子成功率高于银粉玻璃离子,有统计学差异(P<0.05).结论 GC FU ji IX玻璃离子是乳磨牙龋齿充填的理想材料,临床效果优于银粉玻璃离子.

  8. 康复新外敷治疗糖尿病足部溃疡%External application of Kang Fu Xin in diabetic foot ulcer

    Institute of Scientific and Technical Information of China (English)

    胡梅

    2012-01-01

      Objective: To study the effect of external application of Kang Fu Xin in diabetic foot ulcer. Methods: Choosed 79 patients of diabetic foot ulcer to divide into two groups with controling the blood sugar, anti-infection, and improve circulation. The study group were treated with external application of Kang Fu Xin in 40 cases, and controled group were treateed with common drug changing. Conclusion: Kang Fu Xin could improve diabetic foot ulcer to coalescence to ameliorate clinical symptoms.%  目的研究康复新治疗糖尿病足部溃疡的疗效。方法在良好控制血糖、抗感染、改善微循环等综合治疗基础之上,将79例糖尿病足患者随机分2组,治疗组40例采用康复新外敷创面;对照组39例采用常规换药。结论康复新疗效由于常规换药,能有效促进糖尿病足部溃疡的愈合,明显改善患者的临床症状。

  9. The past photometric history of the FU Ori-type young eruptive star 2MASS J06593158-0405277 = V960 Mon

    CERN Document Server

    Jurdana-Sepic, R

    2015-01-01

    The known FU Ori-type young eruptive stars are exceedingly rare (a dozen or so confirmed objects) and 2MASS J06593158-0405277, with its 2014 outburst, is likely the latest addition to the family. All members have displayed just one such eruption in their recorded history, an event lasting for decades. To test the FU Ori nature of 2MASS J06593158-0405277, we have reconstructed its photometric history by measuring its brightness on Harvard photographic plates spanning the time interval 1899-1989. No previous large amplitude eruption similar to that initiated in 2014 has been found, as in bona fide FU Ori-type objects. The median value of the brightness in quiescence of 2MASS J06593158-0405277 is B=15.5, with the time interval 1935-1950 characterized by a large variability (~1 mag amplitude) that contrasts with the remarkable photometric stability displayed at later epochs. The variability during 1935-1950 can either be ascribed to some T Tau like activity of 2MASS J06593158-0405277 itself or to the also young a...

  10. Autophagy in human skin squamous cell carcinoma: Inhibition by 3-MA enhances the effect of 5-FU-induced chemotherapy sensitivity.

    Science.gov (United States)

    Zhang, Lili; Zhang, Jie; Chen, Li; Wang, Jianli

    2015-12-01

    Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the role of autophagy in human skin squamous cell carcinoma (SSCC) development and response to therapy it is still unclear. In the present study, we investigated the role of autophagy in SSCC and the relationship with chemotherapy sensitivity. The present study demonstrated that autophagy related gene the microtubule-associated protein 1 light chain 3 (LC3) expression was low in SSCC. The negative correlation with Bcl2 and survivin, and the chemotherapy drug 5-FU increased the level of autophagy and the autophagy inhibitor 3-MA inhibited this effect in SSCC cells, time- and dose-dependently. When SSCC cells were treated first with 3-MA and then with 5-FU, the inhibition of proliferation, migration, invasion and apoptosis of SSCC cells was enhanced. Our results suggested the possibility of autophagy as a potential target in SSCC therapy and 3-MA and 5-FU combination treatment may be an effective SSCC therapy via autophagy modulating.

  11. RGO/AuNR/HA-5FU nanocomposite with multi-stage release behavior and efficient antitumor activity for synergistic therapy.

    Science.gov (United States)

    Yang, Ying; Wang, Yunlong; Zhu, Manzhou; Chen, Yan; Xiao, Yazhong; Shen, Yuhua; Xie, Anjian

    2017-03-16

    A reduced graphene oxide (RGO)/gold nanorod (AuNR)/hydroxyapatite (HA) nanocomposite was designed and successfully synthesized for the first time. An anticancer drug, 5-fluorouracil (5FU), was chosen as a model drug to be loaded in RGO/AuNR/HA. The fabricated RGO/AuNR/HA-5FU showed robust, selective targeting and penetrating efficiency against HeLa cells due to the good compatibility and nontoxicity of HA, and showed excellent synergetic antitumor effects through combined chemotherapy (CT) by 5FU and photothermal therapy (PTT) by both RGO and AuNRs under near-infrared (NIR) laser irradiation. More importantly, this synergistic dual therapy based on RGO/AuNR/HA can also minimize side effects in normal cells and exhibits greater antitumor activity because of a multi-stage drug release ability triggered by the pH sensitivity of HA in the first stage and the combined photothermal conversion capabilities of RGO and AuNRs by means of the NIR laser irradiation in the second stage. This study suggests that the novel RGO/AuNR/HA multi-stage drug delivery system may represent a promising potential application of multifunctional composite materials in the biomedical field.

  12. Clinical Research on Use of Oxaliplcrtin in Combination with HCPT, LV and 5FU in a Regimen for Advanced Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    GuoqingHu; QiangFu; MaolinJin; JieLi; LiangxiPan; YuxianBai; HuaijinWang; JianweiZhang; DingYu

    2004-01-01

    OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m2iv d 1, HCPT6 mg/m2, iv d 1-5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR} were 50%' the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT is effective and results in mild toxicity when used in combined chemotherapy for advanced gastric cancer.

  13. 伤科洁肤液指纹图谱研究%Research on Fingerprint of ShangKe JieFu Lotion by HPLC

    Institute of Scientific and Technical Information of China (English)

    刘效栓; 张小华; 陈二林; 李喜香

    2013-01-01

    目的:应用HPLC法建立伤科洁肤液的指纹图谱。方法:以Waters Symmetry Shield RP18(4.6 mm×250 mm,5μm)色谱柱为分析柱,0.1%甲酸水溶液-乙腈为流动相,梯度洗脱,检测波长为265 nm,流速1.0 mL/min。结果:建立了伤科洁肤液的HPLC指纹图谱。结论:此方法简单准确,稳定可靠,为控制伤科洁肤液的内在质量提供依据。%Objective:To establish the fingerprint of ShangKe JieFu lotion by HPLC method. Method:Water Symmetry Shield RP18 (4.6 mm ×250 mm, 5μm) was adopted as chromatographic column, mobile phase:0.1%formic acid aqueous solution-acetonitrile, gradient elution, detection wavelength was 265nm, flow rate:1.0mL/min. Result:Fingerprint of ShangKe JieFu lotion was built up through HPLC. Conclusion:The method, simple, accurate, stable and reliable, could provide evidence for controlling the quality of ShangKe JieFu lotion.

  14. Oceanographic profile data collected aboard Chinook and Locator as part of project OPR-K977-FU-08 in the Gulf of Mexico from 2008-08-16 to 2008-10-16 (NCEI Accession 0130764)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0130764 includes physical and profile data collected aboard the Chinook and Locator during project OPR-K977-FU-08 in the Gulf of Mexico from...

  15. Latvijas sabiedrisko attiecību speciālistu profesionalitāte: darba devēju sniegtais novērtējums un pašvērtējums (2014)

    OpenAIRE

    Lūse, Everita

    2014-01-01

    Maģistra darba tēma ir „Latvijas sabiedrisko attiecību speciālistu profesionalitāte: darba devēju sniegtais novērtējums un pašvērtējums (2014)”. Darbā izvirzītā problēma ir, vai un kā sabiedrisko attiecību speciālistam piemītošās zināšanas un prasmes ietekmē šī speciālista profesionalitātes pašvērtējumu un darba devēju sniegto novērtējumu. Maģistra darba teorētiskajā daļā aplūkota Dž. Gruniga izstrādātā lieliskuma teorija sabiedriskajās attiecībās, sabiedrisko attiecību speciālistu l...

  16. Tiešsaistes videospēļu “Counter Strike” un “League of Legends” spēlētāju interaktīvā komunikācija

    OpenAIRE

    Kaminskis, Dāvis

    2017-01-01

    Bakalaura darbā „tiešsaistes video spēļu „Counter Strike” un „League of Legends” spēlētāju interaktīvā komunikācija” tiek pētīta verbālās un neverbālās valodas lietošana un tās pielietojums dažādos komunikācijas kanālos. Papildus pēc iegūtajiem datiem un veiktajiem novērojumiem tiek noskaidrots auditorijas (spēlētāju) viedoklis par komunikācijas saturu un nepieciešamību. Darba teorētisko daļu veido daļas par kvalitatīvu komunikāciju, kā arī nodaļas par interaktīvo komunikāciju, tiešsaist...

  17. The Use of Thermal Analysis and Photoacoustic Spectroscopy in the Evaluation of Maltodextrin Microencapsulation of Anthocyanins from Juçara Palm Fruit (Euterpe edulis Mart. and Their Application in Food

    Directory of Open Access Journals (Sweden)

    Ana Paula da Silva dos Passos

    2015-01-01

    Full Text Available Anthocyanins extracted from the pulp of the fruit of juçara palm (Euterpe edulis Mart. were microencapsulated with maltodextrin in order to stabilise them. Photoacoustic spectroscopy was used to investigate the photostability of the microencapsulated samples. Complementary differential scanning calorimetry and scanning electron microscopy measurements were also performed. Lyophilised extract had 14 340.2 mg/L of total anthocyanins, and the microencapsulation effi ciency of 93.6 %. Temperature analysis showed that maltodextrin conferred protection up to 70 °C for 120 min. Scanning electron microscopy showed that the microencapsulated particles had a flake-like morphology with a smooth surface, characteristic of lyophilisation processes. In addition, when added to yogurt, a red colourant was predominant in the samples at pH from 1.5 up to 5.0. Thermal analysis showed a weak interaction between the sample and the encapsulating agent, and photoacoustic data indicated the photostability of the matrix when exposed to light. Yogurts containing microencapsulated anthocyanins showed a more intense pink colour than yogurts treated with pure dye, and sensory analysis demonstrated that they can have good acceptance on the market. Microencapsulation enabled the innovative application of anthocyanins from juçara palm fruit, and complementary techniques allied to the photoacoustic spectroscopy were effective tools for its evaluation.

  18. Lietotāju apkalpošanas kvalitātes novērtēšana publiskajās bibliotēkās izmantojot SERVQUAL metodi

    OpenAIRE

    2007-01-01

    Maģistra darbā raksturota lietotāju apkalpošanas kvalitātes novērtēšana publiskajās bibliotēkās, par pamatu izmantojot SERVQUAL kvalitātes novērtēšanas metodi. Bibliotēkas nepietiekami bieži izvērtē savu darbību. Tāpēc ir nepieciešams novērtēt bibliotēku pakalpojumu piedāvājumu, kā arī izzināt esošās atšķirības sniegtajos pakalpojumos starp lietotāju vēlmēm, interesēm un reāli saņemtajiem pakalpojumiem. Lai novērtētu patreizējo apkalpošanu publiskajās bibliotēkās Latvijā, praktiskajā pētī...

  19. Universālveikala "Stockmann" mārketinga komunikācijas stratēģija pircēju lojalitātes veicināšanai (2008)

    OpenAIRE

    Mečtaļova, Diāna

    2009-01-01

    Izstrādātā bakalaura darba temats ir “Universālveikala „Stockmann” mārketinga komunikācijas stratēģija pircēju lojalitātes veicināšanai (2008)”. Izstrādātā bakalaura mērķis ir veikt “Stockmann” 2008. gadā izmantotās mārketinga komunikācijas stratēģijas analīzi, noskaidrot, vai tā ir bijusi efektīva un veicinājusi pircēju lojalitāti u/v. Darbs sastāv no divām daļām – teorētiskās un empīriskās. Darba teorētiskajā daļā ir apkopoti un analizēti teorētiskie aspekti par mārketinga komunikācijām...

  20. 参橘止咳滴丸止咳祛痰作用的药效学研究%Pharmacodynamic Study on Antitussive and Expectorant Effects of ShenJu ZhiKe Drippling Pills

    Institute of Scientific and Technical Information of China (English)

    李娟; 李晓东; 封士兰; 胡芳弟

    2015-01-01

    Objective:To study antitussive and expectorant effects of ShenJu ZhiKe dripping pills. Methods:Antitussive and expectorant effects of ShenJu ZhiKe dripping pills were evaluated by the experiments of mice with cough induced by ammonia, guinea pig with cough induced by citric acid, guinea pig with cough induced by elec-tricity stimulated superior laryngeal nerve, tracheal phenol red excretion test of the mice, capillary glass-tube expec-toration method of the rats and other methods. Results:The difference indicated statistical meaning in the compari-son of prolonging cough incubation period of experimental animals, reducing cough times, shortening breathing re-covery time of guinea pig induced by electrical stimulation, increasing phenol red excretion amount and expectora-tion amount when different doses groups of ShenJu ZhiKe dripping pills were compared with normal control group (P<0.05). The difference demonstrated statistical meaning in the comparison of prolong incubation period of experi-mental animals, shortening breathing recovery time of guinea pig induced by electrical stimulation, increasing phe-nol red excretion amount and expectoration amount when moderate and high doses groups of ShenJu ZhiKe dripping pills were compared with positive control group (JiZhi syrup) (P<0.05). Conclusion:ShenJu ZhiKe dripping pills show obvious antitussive and expectorant effects, and high dose group is superior to JiZhi syrup group in clinical effects.%目的:研究参橘止咳滴丸的止咳祛痰作用。方法:采用小鼠氨水引咳、豚鼠枸橼酸引咳和电刺激豚鼠喉上神经引咳、小鼠气管段酚红排出法和大鼠气管毛细玻管排痰法等实验方法评价参橘止咳滴丸的止咳祛痰作用。结果:与正常对照组比较,参橘止咳滴丸各剂量组在延长实验动物的咳嗽潜伏期,减少其咳嗽次数,缩短豚鼠电刺激呼吸恢复时间,增加酚红排出量和排痰量等方面,差异有统计学意义(P<0