EFSA ; Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further....... In the present version of FGE.67 eight additional substances have been included. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data...... on metabolism and toxicity. For twenty-two substances [FL-no: 13.029, 13.030, 13.045, 13.052, 13.054, 13.059, 13.061, 13.066, 13.069, 13.070, 13.083, 13.092, 13.101, 13.103, 13.105, 13.106, 13.107, 13.123, 13.138, 13.148, 13.163 and 13.191] a concern for genotoxicity was raised and therefore these were...

Results of the 3rd Review Meeting of the Convention on Nuclear Safety and Preparatory Works for the 4th Meeting

International Nuclear Information System (INIS)

Choi, Young Sung; Choi, Kwang Sik; Kim, Woong Sik

2006-01-01

The 3 rd Review Meeting of the Convention on Nuclear Safety (CNS) took place from April 11-22, 2005. Fifty out of fifty-five Contracting Parties (CPs) participated with over 500 delegates in attendance. It was concluded that all CPs in attendance were in compliance with the requirements of the CNS. It was also noted that although the focus tends to be on the triennial national reports and review meetings, the CNS should emphasize an ongoing process that continually promotes the advancement of nuclear safety. With regard to this continuity process, the President of the 3 rd Review Meeting sent to all the CPs a message to remind of the lessons offered and learned from the Meeting and to put them into action as well. The president also asked that the CPs start in earnest later this year their preparations for the Forth Meeting in 2008. This paper introduces the results of the 3 rd Review Meeting and presents some suggestions on preparatory works that should be done for the next Review Meeting

40 CFR 63.10390 - What management practice standard must I meet?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false What management practice standard must I meet? 63.10390 Section 63.10390 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY....10390 What management practice standard must I meet? You must sterilize full loads of items having a...

77 FR 52061 - 163rd Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of...

Science.gov (United States)

2012-08-28

... DEPARTMENT OF LABOR Employee Benefits Security Administration 163rd Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of Teleconference Meeting Pursuant to the.... 1142, the 163rd open meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans...

The 23rd Annual Meeting of the European Tissue Repair Society (ETRS) in Reims, France

DEFF Research Database (Denmark)

Von den Hoff, Johannes W; Ågren, Sven Per Magnus; Coulomb, Bernard

2014-01-01

The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns.......The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns....

75 FR 57063 - 153rd Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of...

Science.gov (United States)

2010-09-17

... DEPARTMENT OF LABOR Employee Benefits Security Administration 153rd Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of Meeting Pursuant to the authority... 153rd open meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans will be held on...

EFSA ; Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

of two additional substances compared to previous version. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...

40 CFR 63.2475 - What requirements must I meet for transfer racks?

Science.gov (United States)

2010-07-01

... transfer racks? 63.2475 Section 63.2475 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... must I meet for transfer racks? (a) You must comply with each emission limit and work practice standard in table 5 to this subpart that applies to your transfer racks, and you must meet each applicable...

The 3rd Asia–Pacific Transport Working Group (APTWG) Meeting

International Nuclear Information System (INIS)

Jhang, Hogun; Diamond, P.H.; Leconte, M.; Kwon, J.M.; Ida, K.; Tamura, N.; Kosuga, Y.

2014-01-01

This conference report summarizes the contributions to and discussions at the 3rd Asia–Pacific Transport Working Group (APTWG) meeting held in Jeju-island, Korea, on 21–24 May 2013. The main objective of the meeting is to develop a predictive understanding of transport mechanisms in magnetically confined fusion plasmas. In an effort to accomplish this objective, four technical working groups were organized under the headings: (1) transport barrier formation and confinement enhancement, (2) 3D effects and Magnetohydrodynamic–turbulence interaction, (3) momentum transport and non-locality and (4) particle/impurity transport and energetic particles. (conference report)

Minutes of the 23rd meeting of the International Nuclear Data Committee

International Nuclear Information System (INIS)

Nichols, A.L.

2000-06-01

The document contains the reports of the two working groups on 'Nuclear Data Dissemination and Co-ordination' and 'Nuclear Data Technology Transfer and Training', the full report of the 23rd meeting of the International Nuclear Data Committee, and seven appendices

Proceedings of the natural gas RD&D contractors review meeting, Volume II

Energy Technology Data Exchange (ETDEWEB)

Malone, R.D. [ed.

1995-04-01

This is volume II of papers which were presented at the natural gas RD&D contractors review meeting. Topics include: natural gas upgrading, storage, well drilling, completion, and stimulation. Individual papers were processed separately for the United States Department of Energy databases.

3rd Singularity Theory Meeting of Northeast region & the Brazil-Mexico 2nd Meeting on Singularities

CERN Document Server

Neto, Aurélio; Mond, David; Saia, Marcelo; Snoussi, Jawad; BMMS 2/NBMS 3; ENSINO; Singularities and foliations geometry, topology and applications

2018-01-01

This proceedings book brings selected works from two conferences, the 2nd Brazil-Mexico Meeting on Singularity and the 3rd Northeastern Brazilian Meeting on Singularities, that were hold in Salvador, in July 2015. All contributions were carefully peer-reviewed and revised, and cover topics like Equisingularity, Topology and Geometry of Singularities, Topological Classification of Singularities of Mappings, and more. They were written by mathematicians from several countries, including Brazil, Spain, Mexico, Japan and the USA, on relevant topics on Theory of Singularity, such as studies on deformations, Milnor fibration, foliations, Catastrophe theory, and myriad applications. Open problems are also introduced, making this volume a must-read both for graduate students and active researchers in this field.

40 CFR 63.7296 - What emission limitations must I meet for battery stacks?

Science.gov (United States)

2010-07-01

... for battery stacks? 63.7296 Section 63.7296 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., Quenching, and Battery Stacks Emission Limitations and Work Practice Standards § 63.7296 What emission limitations must I meet for battery stacks? You must not discharge to the atmosphere any emissions from any...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 73, Revision 2 (FGE.73Rev2). Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel agrees with the application of the Procedure as performed by the JECFA for all 18 substances [FL-no: 02.114, 02.141, 05.098, 05.104, 05.112, 05.119, 05.123, 08.034, 08.060, 08.067, 09.028, 09.034, 09...... for the materials of commerce have also been considered and for all 18 substances, the information is adequate....

The 23rd Annual Meeting of the European Tissue Repair Society (ETRS) in Reims, France

NARCIS (Netherlands)

Hoff, J.W. Von den; Agren, M.S.; Coulomb, B.; Eming, S.A.; Lataillade, J.J.

2014-01-01

The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns.

The use of a sweetener substitution method to predict dietary exposures for the intense sweetener rebaudioside A.

Science.gov (United States)

Renwick, A G

2008-07-01

There are more published dietary exposure data for intense sweeteners than for any other group of food additives. Data are available for countries with different patterns of sweetener approvals and also for population groups with high potential intakes, such as children and diabetic subjects. These data provide a secure basis for predicting the potential intakes of a novel intense sweetener by adjustment of the reported intakes of different sweeteners in mg/kg body weight by their relative sweetness intensities. This approach allows the possibility that a novel sweetener attains the same pattern and extent of use as the existing sweeteners. The intakes by high consumers of other sweeteners allows for possible brand loyalty to the novel sweetener. Using this method, the estimated dietary exposures for rebaudioside A in average and high consumers are predicted to be 1.3 and 3.4mg/kg body weight per day for the general population, 2.1 and 5.0mg/kg body weight per day for children and 3.4 and 4.5mg/kg body weight per day for children with diabetes. The temporary ADI defined by the JECFA for steviol glycosides [JECFA, 2005. Steviol glycosides. In: 63rd Meeting of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization (WHO), Geneva, Switzerland, WHO Technical Report Series 928, pp. 34-39] was set at 0-2mg/kg body weight (expressed as steviol equivalents); after correction for the difference in molecular weights, these estimated intakes of rebaudioside A are equivalent to daily steviol intakes of less than 2mg/kg. In consequence, this analysis shows that the intakes of rebaudioside A would not exceed the JECFA temporary ADI set for steviol glycosides.

The role of validated analytical methods in JECFA drug assessments and evaluation for recommending MRLs.

Science.gov (United States)

Boison, Joe O

2016-05-01

The Joint Food and Agriculture Organization and World Health Organization (FAO/WHO) Expert Committee on Food Additives (JECFA) is one of three Codex committees tasked with applying risk analysis and relying on independent scientific advice provided by expert bodies organized by FAO/WHO when developing standards. While not officially part of the Codex Alimentarius Commission structure, JECFA provides independent scientific advice to the Commission and its specialist committees such as the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF) in setting maximum residue limits (MRLs) for veterinary drugs. Codex methods of analysis (Types I, II, III, and IV) are defined in the Codex Procedural Manual as are criteria to be used for selecting methods of analysis. However, if a method is to be used under a single laboratory condition to support regulatory work, it must be validated according to an internationally recognized protocol and the use of the method must be embedded in a quality assurance system in compliance with ISO/IEC 17025:2005. This paper examines the attributes of the methods used to generate residue depletion data for drug registration and/or licensing and for supporting regulatory enforcement initiatives that experts consider to be useful and appropriate in their assessment of methods of analysis. Copyright © 2016 Her Majesty the Queen in Right of Canada. Drug Testing and Analysis © 2016 John Wiley & Sons, Ltd. © 2016 Her Majesty the Queen in Right of Canada. Drug Testing and Analysis © 2016 John Wiley & Sons, Ltd.

Proceedings of the 3rd topical meeting on FEL and high power radiation

International Nuclear Information System (INIS)

Hiramatsu, Shigenori

1994-01-01

The meeting was held on June 10 and 11, 1993, at the National Laboratory for High Energy Physics. This is the joint study meeting with 31st large power microwave-milliwave study meeting. At the meeting, lectures were given on the report of 1st Asia FEL study meeting, infrared free electron laser (FEL) project in JAERI, present state of Free Electron Laser Research Institute Inc., infrared FEL experiment in the Institute of Scientific and Industrial Research, Osaka University, FEL experiment in UVSOR storage ring, NIJI-4 SRFEL, simulation of FEL oscillation in photo-klystron, vacuum UVFEL in PF, beam characteristics of small photon storage ring, micro-cherenkov FEL using field emission array, coherent spontaneous emission and radiation build-up in FEL oscillator, stability of soft X-ray multilayers under exposure to multipole Wigger radiation, long life Zn 2 excimer excited with relativistic electron beam, development of large power klystron in KEK, design of 1 THz gyrotron and first experiment, experiment of relativistic peniotron, experiments of 3rd and 10th cyclotron harmonic peniotron oscillators and others. (K.I.)

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. For nine substances [FL-no: 12.088, 12.179, 12.198, 12.212, 12.238, 12.239, 12.255, 12.257 and 12.291] considered in this FGE, the Panel...... concluded that they would pose “No safety concern at estimated levels of intake as flavouring substances” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered for the substances evaluated through...

40 CFR 63.5743 - What standards must I meet for aluminum recreational boat surface coating operations?

Science.gov (United States)

2010-07-01

... recreational boat surface coating operations? 63.5743 Section 63.5743 Protection of Environment ENVIRONMENTAL... Manufacturing Standards for Aluminum Recreational Boat Surface Coating Operations § 63.5743 What standards must I meet for aluminum recreational boat surface coating operations? (a) For aluminum wipedown solvent...

40 CFR 63.5731 - What standards must I meet for resin and gel coat mixing operations?

Science.gov (United States)

2010-07-01

... and gel coat mixing operations? 63.5731 Section 63.5731 Protection of Environment ENVIRONMENTAL... Manufacturing Standards for Resin and Gel Coat Mixing Operations § 63.5731 What standards must I meet for resin and gel coat mixing operations? (a) All resin and gel coat mixing containers with a capacity equal to...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 91, Re vision 2 (FGE.91Rev2): Consid eration of simple aliphatic and aromatic sulphides and thiols evaluated by the JECFA (53rd and 68th meetings

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. For 36 substances considered in this FGE the Panel concluded that they would pose “No safety concern at estimated levels of intake...... related substance. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 44 substances, the information is adequate. For candidate substance 3-(methylthio)heptenal [FL-no: 12.273], which contains 5 to7 % of an α...

143rd and 144th meetings of the Governing Board of the Pension Fund

CERN Multimedia

2006-01-01

The Governing Board of the Pension Fund held its 143rd and 144th meetings on 16 May and 13 June respectively. At the first of these two meetings, the Board took note of the report by the Austrian Court of Audit on the 2005 financial year and of the associated comments by the Administration of the Fund. It also listened to a report by the Chairman of the Investment Committee on the latter's 10 May meeting, at which the two fund managers responsible for the "QUAM" and "Far East Ex-Japan" portfolios had been interviewed and their performances judged satisfactory. The Committee had also decided to commission ORTEC to carry out a full assets/liabilities modelling study during the current year. During the meeting, the Board also approved a document setting out its position on the CERN debt to the Pension Fund, which would be submitted to the Finance Committee and Council in June. It underlined that the reimbursement of the debt would be advantageous for the Fund as well as for the Laboratory and that it would re...

40 CFR 63.7925 - What emissions limitations and work practice standards must I meet for closed vent systems and...

Science.gov (United States)

2010-07-01

... What emissions limitations and work practice standards must I meet for closed vent systems and control... 40 Protection of Environment 13 2010-07-01 2010-07-01 false What emissions limitations and work practice standards must I meet for closed vent systems and control devices? 63.7925 Section 63.7925...

40 CFR 63.5810 - What are my options for meeting the standards for open molding and centrifugal casting operations...

Science.gov (United States)

2010-07-01

... standards for open molding and centrifugal casting operations at new and existing sources? 63.5810 Section... § 63.5810 What are my options for meeting the standards for open molding and centrifugal casting... (d) of this section to meet the standards for open molding or centrifugal casting operations in Table...

40 CFR 63.5734 - What standards must I meet for resin and gel coat application equipment cleaning operations?

Science.gov (United States)

2010-07-01

... and gel coat application equipment cleaning operations? 63.5734 Section 63.5734 Protection of... Pollutants for Boat Manufacturing Standards for Resin and Gel Coat Application Equipment Cleaning Operations § 63.5734 What standards must I meet for resin and gel coat application equipment cleaning operations...

40 CFR 63.5985 - What are my alternatives for meeting the emission limits for tire production affected sources?

Science.gov (United States)

2010-07-01

... the emission limits for tire production affected sources? 63.5985 Section 63.5985 Protection of... Pollutants: Rubber Tire Manufacturing Emission Limits for Tire Production Affected Sources § 63.5985 What are my alternatives for meeting the emission limits for tire production affected sources? You must use...

40 CFR 63.5698 - What emission limit must I meet for open molding resin and gel coat operations?

Science.gov (United States)

2010-07-01

... open molding resin and gel coat operations? 63.5698 Section 63.5698 Protection of Environment... Manufacturing Standards for Open Molding Resin and Gel Coat Operations § 63.5698 What emission limit must I meet for open molding resin and gel coat operations? (a) You must limit organic HAP emissions from the five...

Announced document collection of the 3rd information exchange meeting on radioactive waste disposal research network

International Nuclear Information System (INIS)

2008-03-01

The 3rd meeting on 'Radioactive Waste Disposal Research Network' was held at the Ricotti techno community square of JAEA on September 3 and 4, 2007. The 'Radioactive Waste Disposal Research Network' was established in Interorganization Atomic Energy Research Program under academic collaborative agreement between Japan Atomic Energy Agency and the University of Tokyo. The objective is to bring both research infrastructures and human expertise in Japan to an adequate performance level, thereby contributing to the development of the fundamental research area in the field of radioactive waste disposal. This lecture material is a collection of presentations and discussions during the information exchange meeting. (author)

40 CFR 63.5820 - What are my options for meeting the standards for continuous lamination/casting operations?

Science.gov (United States)

2010-07-01

... standards for continuous lamination/casting operations? 63.5820 Section 63.5820 Protection of Environment... meeting the standards for continuous lamination/casting operations? You must use one or more of the... continuous lamination line and each continuous casting line complies with the applicable standard. (b...

40 CFR 63.7293 - What work practice standards must I meet for fugitive pushing emissions if I have a non-recovery...

Science.gov (United States)

2010-07-01

... meet for fugitive pushing emissions if I have a non-recovery coke oven battery? 63.7293 Section 63.7293... Standards for Hazardous Air Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Emission... pushing emissions if I have a non-recovery coke oven battery? (a) You must meet the requirements in...

Lecture Notes in Statistics. 3rd Semester

DEFF Research Database (Denmark)

The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models.......The lecture note is prepared to meet the requirements for the 3rd semester course in statistics at the Aarhus School of Business. It focuses on multiple regression models, analysis of variance, and log-linear models....

40 CFR 63.7887 - What are the general standards I must meet for my affected equipment leak sources?

Science.gov (United States)

2010-07-01

... meet for my affected equipment leak sources? 63.7887 Section 63.7887 Protection of Environment... affected equipment leak sources? (a) You must control HAP emissions from equipment leaks from each equipment component that is part of the affected source by implementing leak detection and control measures...

40 CFR 63.5805 - What standards must I meet to comply with this subpart?

Science.gov (United States)

2010-07-01

... CATEGORIES National Emissions Standards for Hazardous Air Pollutants: Reinforced Plastic Composites.... Use the procedures in § 63.5799 to determine if you meet or exceed the 100 tpy threshold. (a) If you... must reduce the total organic HAP emissions from centrifugal casting and continuous lamination/casting...

3rd International Conference on Transcriptomics

OpenAIRE

John A Daniel

2017-01-01

Conference Series has been instrumental in conducting international Biochemistry meetings for seven years, and very excited to expand Europe, America and Asia Pacific continents. Previous meetings were held in major cities like Philadelphia, Orlando with success the meetings again scheduled in three continents. 3rd International Conference on Transcriptomics to be held during October 30 - November 01, 2017 at Bangkok, Thailand The Global Transcriptomics business sector to develop at a C...

3rd Bayesian Young Statisticians Meeting

CERN Document Server

Lanzarone, Ettore; Villalobos, Isadora; Mattei, Alessandra

2017-01-01

This book is a selection of peer-reviewed contributions presented at the third Bayesian Young Statisticians Meeting, BAYSM 2016, Florence, Italy, June 19-21. The meeting provided a unique opportunity for young researchers, M.S. students, Ph.D. students, and postdocs dealing with Bayesian statistics to connect with the Bayesian community at large, to exchange ideas, and to network with others working in the same field. The contributions develop and apply Bayesian methods in a variety of fields, ranging from the traditional (e.g., biostatistics and reliability) to the most innovative ones (e.g., big data and networks).

40 CFR 63.6604 - What fuel requirements must I meet if I own or operate an existing stationary CI RICE?

Science.gov (United States)

2010-07-01

... I own or operate an existing stationary CI RICE? 63.6604 Section 63.6604 Protection of Environment....6604 What fuel requirements must I meet if I own or operate an existing stationary CI RICE? If you own or operate an existing non-emergency CI stationary RICE with a site rating of more than 300 brake HP...

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Nørby, Karin Kristiane

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further......-no: 14.003] and deca-(2E,4E)-dienoic acid isobutyl-amide [FL-no: 16.091]. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological thresholds of concern and available data on metabolism and toxicity...... for the materials of commerce have also been considered and for all 30 substances, the information is adequate....

Meeting Report of the 33rd Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Las Vegas, NV, October 4-6, 2017.

Science.gov (United States)

Graham, Melanie L; Ziegelhofer, Tracy; Ehrmann, Jon

2018-04-11

The 33rd Annual Meeting of the Academy of Surgical Research was held from October 4 to 6, 2017 in Las Vegas, Nevada. The meeting welcomed >160 participants from 27 different states and five countries representing the organization's diverse membership of technicians, veterinarians, medical doctors, and biomedical researchers. The Academy's annual meeting is focused on promoting the advancement of professional and academic standards, education, and research related to the art and science of experimental surgery. Presentations included four invited keynote speakers and 30 selected lectures and posters. A primary strength of the meeting was that lectures were complimented with practical sessions that included four wet lab and two dry lab half-day courses. Likewise, participants were brought together in workshops emphasizing research workflow from starting experimental design to readying results for publication. In this report, we present the highlights from this meeting and some selected abstracts that illustrate the diverse scientific expertise of the Academy and progress in surgical research.

40 CFR 63.2465 - What requirements must I meet for process vents that emit hydrogen halide and halogen HAP or HAP...

Science.gov (United States)

2010-07-01

... process vents that emit hydrogen halide and halogen HAP or HAP metals? 63.2465 Section 63.2465 Protection... and halogen HAP or HAP metals? (a) You must meet each emission limit in Table 3 to this subpart that... section. (b) If any process vents within a process emit hydrogen halide and halogen HAP, you must...

40 CFR 63.7292 - What work practice standards must I meet for fugitive pushing emissions if I have a by-product...

Science.gov (United States)

2010-07-01

... meet for fugitive pushing emissions if I have a by-product coke oven battery with horizontal flues? 63... meet for fugitive pushing emissions if I have a by-product coke oven battery with horizontal flues? (a...) Prepare and operate by a written plan that will eliminate or minimize incomplete coking for each by...

40 CFR 63.7291 - What work practice standards must I meet for fugitive pushing emissions if I have a by-product...

Science.gov (United States)

2010-07-01

... meet for fugitive pushing emissions if I have a by-product coke oven battery with vertical flues? 63... meet for fugitive pushing emissions if I have a by-product coke oven battery with vertical flues? (a... existing by-product coke oven battery with vertical flues. (1) Observe and record the opacity of fugitive...

EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 73, Revision 1: Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... substance compared to the previous version. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel agrees...... levels of intake as flavouring substances” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 16 substances, the information is adequate....

3rd International Meeting for Researchers in Materials and Plasma Technology (IMRMPT) and 1st Symposium on Nanoscience and Nanotechnology

International Nuclear Information System (INIS)

2016-01-01

These proceedings present the written contributions of the participants of the 3rd International Meeting for Researchers in Materials and Plasma Technology (3rd IMRMPT) and the 1st Symposium on Nanoscience and Nanotechnology which was held from 4 to May 9, 2015 at the Dann Carlton Hotel Bucaramanga, Colombia, organized by the faculty of science of the Universidad Industrial de Santander (UIS) and the basic science department of the Universidad Pontificia Bolivariana. This was the third version of biennial meetings that began in 2011. The five-day scientific program of the 3rd IMRMPT consisted of 24 Magisterial Conferences, 70 Oral Presentations, 185 Poster Presentations, 3 Courses and 1 Discussion Panel with the participation of undergraduate and graduate students, professors, researchers and entrepreneurs from Colombia, Russia, Germany, France, Spain, England, United States, Mexico, Argentina, Uruguay, Brazil, Venezuela, among others. Moreover, the objective of IMRMPT was to bring together national and international researchers in order to establish a network of scientific cooperation with a global impact in the area of the science and the technology of materials; to promote the exchange of creative ideas and the effective transfer of scientific knowledge, from fundamental research to innovation applied to industrial solutions and to advances in the development of new research allowing to increase the lifetime of the materials used in the industry by means of efficient transference of the knowledge between sectors academia and industry. The topics covered in the 3rd IMRMPT include New Materials, Surface Physics, Structural Integrity, Renewable Energy, Online Process Control, Non Destructive Evaluation, Characterization of Materials, Laser and Hybrid Processes, Thin Films and Nanomaterials, Surface Hardening Processes, Wear and Corrosion/Oxidation, Plasma Applications and Technologies, Modelling, Simulation and Diagnostics, Biomedical Coatings, Surface Treatments

The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report

NARCIS (Netherlands)

Kager, L.; Whelan, J.; Dirksen, U.; Hassan, B.; Anninga, J.; Bennister, L.; Bovee, J.V.; Brennan, B.; Broto, J.M.; Brugieres, L.; Cleton-Jansen, A.M.; Copland, C.; Dutour, A.; Fagioli, F.; Ferrari, S.; Fiocco, M.; Fleuren, E.D.; Gaspar, N.; Gelderblom, H.; Gerrand, C.; Gerss, J.; Gonzato, O.; Graaf, W.T. van der; Hecker-Nolting, S.; Herrero-Martin, D.; Klco-Brosius, S.; Kovar, H.; Ladenstein, R.; Lancia, C.; Ledeley, M.C.; McCabe, M.G.; Metzler, M.; Myklebost, O.; Nathrath, M.; Picci, P.; Potratz, J.; Redini, F.; Richter, G.H.; Reinke, D.; Rutkowski, P.; Scotlandi, K.; Strauss, S.; Thomas, D; Tirado, O.M.; Tirode, F.; Vassal, G.; Bielack, S.S.

2016-01-01

This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children's Cancer Research Institute in Vienna, Austria on September 24-25, 2015. The joint bone sarcoma network meetings bring together

ESNA: European Society for New Methods in Agricultural Research. 23. annual meeting and 3. German meeting on food irradiation. Book of abstracts

International Nuclear Information System (INIS)

1993-01-01

The book comprises 181 abstracts of the 23rd Annual Meeting of the European Society for New Methods in Agricultural Research and the 3rd German Meeting on Food Irradiation. The following subjects were discussed in six workshops: Radiation Technology and 3rd German Meeting on Food Irradiation (44); Advanced Methods in Animal Sciences (17); Soil-Plant Relationships (36); Plant Genetics, Breeding and Physiology (48); Environmental Aspects and Energy Use (16); Pest Management (20). The abstracts are supplemented by an alphabetic index of authors. (UHE) [de

40 CFR 63.11087 - What requirements must I meet for gasoline storage tanks if my facility is a bulk gasoline...

Science.gov (United States)

2010-07-01

... gasoline storage tanks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11087 What requirements must I meet for gasoline storage tanks if my facility is a bulk gasoline...

EFSA ; Scientific Opinion on Flavouring Group Evaluation 98 (FGE.98): Consideration of three ring-unsaturated delta-lactones)

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of three unsaturated delta-lactones [FL-no: 10.031, 10.037 and 10.044] previously evaluated by the JECFA at their 49th meeting in 1997. The JECFA considered that further information...... on the metabolism of these three substances was required and that they should be evaluated together with other substances containing alpha,beta-unsaturation and that, therefore, their evaluation should be deferred. However, the EFSA Panel has considered that these three JECFA evaluated aliphatic lactones can...... be hydrolysed and metabolised to innocuous products in line with the aliphatic lactones evaluated by EFSA in FGE.10Rev2. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern...

40 CFR 63.1360 - Applicability.

Science.gov (United States)

2010-07-01

... Hazardous Air Pollutants for Pesticide Active Ingredient Production § 63.1360 Applicability. (a) Definition... commenced after November 10, 1997. (2) Any dedicated PAI process unit that meets the criteria specified in... elect to designate production of any intermediate that does not meet the definition of integral...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids) , 2016. Scientific Opinion on Flavouring Group Evaluation 90, Revision 1 (FGE.90Rev1): consideration of six substances evaluated by JECFA (68th meeting) structurally related to aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters evaluated by EFSA in FGE.18Rev1 and FGE.75Rev1

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Nørby, Karin Kristiane

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of EFSA was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary...... refined exposure estimation and to judge whether a re-evaluation according to the Procedure is needed....

Proceedings of Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting (23rd) held in Pasadena, California on December 3-5, 1991

Science.gov (United States)

1991-12-05

Between Two Western European Time Laboratories and VNIIFTRI ............. 341 P Daly, University of Leeds, N.B. Koshelyaevsky, VNIIFTRI , and W Lewandowski...equipped with GPS time receivers and contributing to TAI. The last GPS antenna position determined by the BIPM is installed near Moscow in the VNIIFTRI : it...Leeds and VNIIFTRI ", accepted in Proc. 23rd Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting, 1991. 15. W. Lewandowski and

103rd Meeting of the SPSC

CERN Multimedia

Morna Robillard

2011-01-01

from Tuesday 25 October 2011 at 09:00 to Wednesday 26 October 2011 at 16:00 Council Chamber, Bldg. 503 News from the Non-LHC Experiments at CERN Claude Vallee / CPPM Marseille Tuesday 25 October 2011 09:00 - 13:00 OPEN SESSION 09:00 Status and plans of the NA61 experiment 30' Speaker:  Marek Gazdzicki / Johann-Wolfgang-Goethe Univ. (DE) 09:40 Status and plans of the NA63 experiment 20' Speaker:  Ulrik Uggerhoj 10:10 Status and plans of the CAST experiment 30' Speaker:  Esther Ferrer Ribas / IRFU/CEA-Saclay 10:50 Coffee Break 20' 11:10 Status and plans of the OSQAR experiment 30' Speaker:  Pierre Pugnat / CNRS - LNCMI-G (Laboratoire National des Champs Magnétiques Intenses de Grenoble 11:50 Status and plans of the UA9 experiment 20' Speaker:  Walter Scandale / Universite de Paris-Sud 11 (FR) 12:20 A proposal to measure the gravitational behaviour of antihydrogen at rest 30' Speaker:  Patr...

75 FR 58350 - Meeting

Science.gov (United States)

2010-09-24

... UNITED STATES ARCTIC RESEARCH COMMISSION Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its 94th meeting in Fairbanks, AK, on October 6-8, 2010. The business session... approval of the agenda. (2) Approval of the minutes from the 93rd meeting. (3) Commissioners and staff...

40 CFR 63.1350 - Monitoring requirements.

Science.gov (United States)

2010-07-01

... leak detection system include concepts from EPA's “Fabric Filter Bag Leak Detection Guidance” (EPA-454... order to meet the emission limits and operating limits of §§ 63.1343 through 63.1348; (2) Corrective... inspection of the components of the combustion system of each kiln and each in-line kiln raw mill located at...

40 CFR 63.1032 - Sampling connection systems standards.

Science.gov (United States)

2010-07-01

... device that meets the requirements of either § 63.1034 or § 63.1021(b); or (4) Collect, store, and... facility permitted, licensed, or registered by a State to manage municipal or industrial solid waste, if...

Building effective R&D capabilities abroad.

Science.gov (United States)

Kuemmerle, W

1997-01-01

In the past, companies kept most of their research and development activities in their home country because they thought it important to have R&D close to where strategic decisions were being made. But today many companies choose to establish R&D networks in foreign countries in order to tap the knowledge there or to commercialize products for those markets at a competitive speed. Adopting a global approach entails new, complex managerial challenges. It means linking R&D strategy to a company's overall business strategy. The first step in adopting such an approach is to build a team to lead the initiative--a team whose members are sufficiently senior to be able to mobilize resources at short notice. Second, companies must determine whether an R&D site's primary objective is to augment the expertise that the home base has the offer or to exploit that knowledge for use in the foreign country. That determination affects the choice of location and staff. For example, to augment the home base laboratory, a company would want to be near a foreign university; to exploit the home base laboratory it would need to be near large markets and manufacturing facilities. The best individual for managing both types of site combines the qualities of good scientist and good manager, knows how to integrate the new site with existing sites, understand technology trends, and is good at gaining access to foreign scientific communities. As more pockets of knowledge emerge around the globe and competition in foreign markets mounts, only those companies that embrace an informed approach to global R&D will be able to meet the new challenges.

Public meetings

CERN Multimedia

Staff Association

2014-01-01

  MARS 2015 FIVE YEARLY REVIEW CONTRACT POLICY PENSION FUND GENERAL INFORMATION   COME AND BE INFORMED! PUBLIC MEETINGS Friday 3rd October at 10 am Amphi BE, 864-1-D02 Prévessin Friday 3rd October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 (in English) Meyrin Monday 6th October at 10 am Kjell Johnsen Auditorium, 30-7-018 Meyrin Monday 6th October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 Meyrin  

Teacher education - meeting the needs of the new generation

DEFF Research Database (Denmark)

2014-01-01

Temanr. fra konferencen: Teacher Education: Meeting the Needs of the New Generation 33rd Annual Seminar of International Society for Teacher Education, Hong Kong Baptist University, Hong Kong, May 27 – 31, 2013......Temanr. fra konferencen: Teacher Education: Meeting the Needs of the New Generation 33rd Annual Seminar of International Society for Teacher Education, Hong Kong Baptist University, Hong Kong, May 27 – 31, 2013...

Kokes Awards for the 23rd North American Catalysis Society Meeting

Energy Technology Data Exchange (ETDEWEB)

Jacobs, Gary [University of Kentucky Research Foundation, Lexington, KY (United States)

2014-01-31

The Tri-State Catalysis Society awarded 107 Kokes Travel Awards. The program was very successful and to date this was the most Kokes Travel Awards ever awarded at a North American Catalysis Society Meeting. It provided students who merited an award the opportunity to attend the meeting, present a paper in the form of either an oral presentation or a poster presentation, and to serve the North American Catalysis Society by participating in the organization of the meeting. Students worked very hard during the week of the meeting to make it a success. Financial support for the Kokes awards was provided by DOE, NSF, NACS, as well as the Tri-State Catalysis Society, the latter through fund raising activities, and other donations. AT the meeting, each student received over $1050 in kind to offset the costs of registration fees ($260), hotel accommodations ($295.7), transportation ($400 travel allowance), as well as T-shirts ($20), and banquet tickets ($95 provided by donations from society members). In addition, for the first time, students received certificates that were signed by the President of NACS, Professor Enrique Iglesia, and by the Kokes Awards Chair, Gary Jacobs (see last page). A list of meeting co-chairs (i.e., Uschi M. Graham, Umit S. Ozkan, and Madan Bhassin) and the honorary chair (Burtron H. Davis) was also included on the certificate, along with the name of the recipient. The awardees were chosen on a merit-based guideline which also included the requirements of having a presentation accepted at the meeting and being a student at a North American University. The Richard J. Kokes Student Travel Award Committee (Gary Jacobs, Rodney Andrews, and Peter Smirniotis) with help from the Organizing Committee were able to secure money from four sources as detailed in Table 1. As detailed by our Treasurer, Dr. Helge Toufar of Clariant, the total amount spent was $105,000.

Third (3rd) Research Coordination Meeting of the CRP on Development of Methodologies for the Assessment of Passive Safety System Performance in Advanced Reactors. Presentations

International Nuclear Information System (INIS)

2011-01-01

Purpose of the meeting: • To review progress and milestones on all research activities; • To discuss the preliminary experimental data obtained from the Natural Circulation Loop Facility L2 in Italy constructed for the assessment of different methodologies for the evaluation of the reliability of passive safety system; • To discuss lessons-to be-learned from the Fukushima Daiichi Accident in Japan and its implications to near future R&D needs on thermal-hydraulics and reactor safety; • To develop an outline of integrated annual technical report and future collaboration plan

3rd Karl Schwarzschild Meeting - Gravity and the Gauge/Gravity Correspondence

Science.gov (United States)

Nicolini, Piero; Kaminski, Matthias; Mureika, Jonas; Bleicher, Marcus

2018-01-01

The Karl Schwarzschild Meeting 2017 (KSM2017) has been the third instalment of the conference dedicated to the great Frankfurter scientist, who derived the first black hole solution of Einstein's equations about 100 years ago. The event has been a 5 day meeting in the field of black holes, AdS/CFT correspondence and gravitational physics. Like the two previous instalments, the conference continued to attract a stellar ensemble of participants from the world's most renowned institutions. The core of the meeting has been a series of invited talks from eminent experts (keynote speakers) as well as the presence of plenary research talks by students and junior speakers.

TMS 2014 143rd Annual Meeting & Exhibition, Annual Meeting Supplemental Proceedings (ISBN: 978-1-118-88972-5)

Energy Technology Data Exchange (ETDEWEB)

Nielsen, K; Zhukov, A; Ipatov, M; Talaat, A; Blanco, J; Zhukova, V; Churyukanova, M; Kaloshkin, S; Zamiatkina, E; Shuvaeva, E; Gonzalez-Legarreta, L; Hernando, B

2015-03-02

The Magnetic Materials for Energy Applications IV, held at the 2014, 143rd Annual Meeting of The Minerals, Metals, and Materials Society (TMS), brought together experts, young investigators, and students from this sub-discipline of materials science in order for them to share their latest discoveries and develop collaborations. This symposium, which is organized by The Minerals, Metals, and Materials Society, is an important event for this community of scientists. This year, over 50 high-level technical talks were planned over the course of the event. In addition, the students and young investigators in attendance ensured the maximum benefit to the next generation’s work force in this area of study. Meeting global energy needs in a clean, efficient, secure and sustainable manner is arguably the greatest challenge facing mankind today. Magnetic materials play a critical role in myriad devices for the collection, conversion, transmission and storage of energy. For example, high performance permanent magnets are currently in great demand for the generators in wind turbines and electric motors in hybrid vehicles. Other classes of advanced magnetic materials are essential for efficient inductors/transformers and motors. Energy efficient cooling based on the magnetocaloric effect is another exciting possibility which is rapidly becoming industrially viable. The potential energy savings related to refrigeration and air conditioning based on magnetocaloric materials are highly attractive. This symposium allowed experts in areas relating to the advanced characterization, simulation, and optimization of magnetic materials to convene and present their latest research. The types of interactions afforded by this event are beneficial to society at large primarily because they provide opportunities for the leaders within this field to learn from one another and thus improve the quality and productivity of their investigations. Additionally, the presence of young investigators

Solubility Testing of Sucrose Esters of Fatty Acids in International Food Additive Specifications.

Science.gov (United States)

Nagai, Yukino; Kawano, Satoko; Motoda, Kenichiro; Tomida, Masaaki; Tatebe, Chiye; Sato, Kyoko; Akiyama, Hiroshi

2017-03-01

We investigated the solubility of 10 samples of sucrose esters of fatty acids (SEFA) products that are commercially available worldwide as food additives (emulsifiers). Although one sample dissolved transparently in both water and ethanol, other samples produced white turbidity and/or precipitates and did not meet the solubility criterion established by the Joint Food and Agriculture Organization of the United Nations (FAO)/WHO Expert Committee on Food Additives (JECFA). When the sample solutions were heated, the solubility in both water and ethanol increased. All of the samples dissolved transparently in ethanol, and dispersed and became white without producing precipitates in water. The present study suggests that the current solubility criterion of the JECFA SEFA specifications needs to be revised.

R&D cooperation versus R&D subcontracting: empirical evidence from French survey data.

OpenAIRE

Estelle Dhont-Peltrault; Etienne Pfister

2007-01-01

This paper uses a survey of French firms active in R&D to identify the determinants of R&D outsourcing and of the ensuing trade-off between R&D subcontracting and R&D cooperation. Internal R&D expenditures increase both the probability of outsourcing and the number of R&D partners. Investment in fundamental R&D, group belonging, and the sector’s high R&D intensity positively influences the probability of R&D outsourcing but have less impact on the number of partners. R&D subcontracting is mor...

40 CFR 63.1569 - What are my requirements for HAP emissions from bypass lines?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for HAP emissions from bypass lines? 63.1569 Section 63.1569 Protection of Environment ENVIRONMENTAL PROTECTION... HAP emissions from bypass lines? (a) What work practice standards must I meet? (1) You must meet each...

R&D tax incentives for innovation and managerial decisions

Directory of Open Access Journals (Sweden)

Monika Walicka

2016-09-01

Full Text Available In many countries tax incentives are a popular means of realizing political, economic and social objectives. The main motive of their application is often to achieve and accelerate the selected activities in the public interest and also stimulate development of industry, and induce growth in research and investment. The key element that helps a company achieve a competitive advantage is innovation. Global competition forces the production of unique products and services. Tax incentives in science, research and development are important in stimulating innovation. The purpose of this article is to show the level of managerial awareness about R&D tax incentives, the level of R&D tax incentive usage by companies in Poland, and main obstacles that managers meet with R&D tax incentives in practice. We explore R&D tax incentives as a government instrument on R&D management and aim to find the reasons why Polish companies do not take advantage of them. We examine 275 companies using a semi-structured questi onnaire. Our findings suggest that many firms report lack of knowledge about such incentives, and firms find many obstacles to reach all of the requirements which are necessary to use the incentive. Due to our analysis we find that large firms, especially those that implement innovation, are more likely to use the tax incentives, but small and medium sized companies find more obstacle. The effect of this tax policy is significant mainly in large, high-tech sector firms.

23rd annual meeting of German Society for Neuroradiology

International Nuclear Information System (INIS)

Kuehne, D.

1987-01-01

Book of abstracts of this annual meeting summarizing the 58 lectures that dealt with the following subjects: Pathologic changes of the cervical vertebral canal and of the cervico-occipital region, as detected by modern imaging techniques (18 papers); diagnostic examination of the urbita and the middle cranial fossa (12 papers); invasive methods of neuroradiology (13 papers); 15 papers on freely chosen subjects. (MG) [de

A note on duplication of R&D and R&D subsidies

OpenAIRE

Sami Dakhlia; Akram Temimi; Flavio Menezes

2004-01-01

We show that the presumed incompatibility of uncoordinated R&D and competition is not fundamental, but hinges on the nature of R&D spillovers. As a consequence, R&D subsidies may be more effective than previously thought.

75 FR 65485 - Sunshine Act Meeting

Science.gov (United States)

2010-10-25

... Asia-Pacific Economic Cooperation-- 33rd Transportation Working Group Meeting. 2. Commission Review of... Agreement, FMC Agreement No. 011223. 3. Staff Briefing Regarding China Maritime Regulatory Issues. Contact...

R&D Proposal RD51 Extension Beyond 2018

CERN Document Server

Dalla Torre, S; Ropelewski, L; Titov, M

2018-01-01

The RD51 Collaboration, in charge of the development and dissemination of MicroPattern Gaseous Detectors (MPGD) since 2008, proposes to extend its ac-tivity, after 2018, for a further five-year term. Since the RD51 initial years, the community of MPGD developers and users has grown considerably. It is reflected by the many MPGD-based applications in high energy and nuclear physics experi-ments as well as in other basic and applied-research fields. They rely on the parallel progress of detector concepts and associated technologies. The cultural, infrastruc-ture and networking support offered by RD51 has been essential in this process. The rich portfolio of MPGD projects, under constant expansion, is accompanied by novel ideas on further developments and applications. The proposed next term of RD51 activities aims at bringing a number of de-tector concepts to maturity, initiating new projects and continuing the support to the community. Among leading proposed projects are ultrafast, high-rate MPGDs; discharg...

77 FR 32169 - SJI Board of Directors Meeting, Notice

Science.gov (United States)

2012-05-31

... meeting is to consider grant applications for the 3rd quarter of FY 2012, and other business. All portions of this meeting are open to the public. ADDRESSES: Westin Hotel, 1900 5th Ave., Seattle, WA 98101...

Multiple R&D projects scheduling optimization with improved particle swarm algorithm.

Science.gov (United States)

Liu, Mengqi; Shan, Miyuan; Wu, Juan

2014-01-01

For most enterprises, in order to win the initiative in the fierce competition of market, a key step is to improve their R&D ability to meet the various demands of customers more timely and less costly. This paper discusses the features of multiple R&D environments in large make-to-order enterprises under constrained human resource and budget, and puts forward a multi-project scheduling model during a certain period. Furthermore, we make some improvements to existed particle swarm algorithm and apply the one developed here to the resource-constrained multi-project scheduling model for a simulation experiment. Simultaneously, the feasibility of model and the validity of algorithm are proved in the experiment.

40 CFR 63.11170 - Am I subject to this subpart?

Science.gov (United States)

2010-07-01

... meet the definition of facility maintenance or space vehicle in § 63.11180. (b) An area source of HAP... coatings, as defined in § 63.11180, to motor vehicles and mobile equipment including operations that are located in stationary structures at fixed locations, and mobile repair and refinishing operations that...

Collaborative Product Development in an R&D Environment

Science.gov (United States)

Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.; Peterson, Paul L.

2004-01-01

Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

Audio-Visual Processing in Meetings: Seven Questions and Current AMI Answers

NARCIS (Netherlands)

Al-Hamas, Marc; Hain, Thomas; Cernocky, Jan; Schreiber, Sascha; Poel, Mannes; Rienks, R.J.

2007-01-01

The project Augmented Multi-party Interaction (AMI) is concerned with the development of meeting browsers and remote meeting assistants for instrumented meeting rooms – and the required component technologies R&D themes: group dynamics, audio, visual, and multimodal processing, content abstraction,

R&D Nuggets

Science.gov (United States)

RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About &D Nuggets Database dropdown arrow Search Tag Cloud Browse Reports Database Help Finding Aids

Outsourcing R&D

DEFF Research Database (Denmark)

Hsuan, Juliana; Mahnke, Volker

2011-01-01

Outsourcing R&D is an increasingly explored corporate practice. Extant research advanced our initial understanding of its increasing importance and benefits. While the associated literature has blossomed, the enthusiasm of R&D managers is tenured by an increasing realization of the possible......&D, suggest a simple, yet integrative model on the relation between outsourcing R&D and performance, and offer a research agenda that is instrumental in guiding companies’ process-management and design strategies when seeking to benefit from the outsourcing of R&D....

ATLAS & Google — "Data Ocean" R&D Project

CERN Document Server

The ATLAS collaboration

2017-01-01

ATLAS is facing several challenges with respect to their computing requirements for LHC Run-3 (2020-2023) and HL-LHC runs (2025-2034). The challenges are not specific for ATLAS or/and LHC, but common for HENP computing community. Most importantly, storage continues to be the driving cost factor and at the current growth rate cannot absorb the increased physics output of the experiment. Novel computing models with a more dynamic use of storage and computing resources need to be considered. This project aims to start an R&D project for evaluating and adopting novel IT technologies for HENP computing. ATLAS and Google plan to launch an R&D project to integrate Google cloud resources (Storage and Compute) to the ATLAS distributed computing environment. After a series of teleconferences, a face-to-face brainstorming meeting in Denver, CO at the Supercomputing 2017 conference resulted in this proposal for a first prototype of the "Data Ocean" project. The idea is threefold: (a) to allow ATLAS to explore the...

78 FR 78506 - Research and Development; Public Meeting

Science.gov (United States)

2013-12-26

... Safety R&D Initiatives on Packaging Testing Paperless Hazard Communications Pilot Program Odorization of.... PHMSA-2013-0261; Notice No. 13-21] Research and Development; Public Meeting AGENCY: Pipeline and... the Research and Development Forum to be held January 17, 2014, in Washington, DC. During this meeting...

International Code Centres Network. Summary Report of the 3rd Biennial Technical Meeting

International Nuclear Information System (INIS)

Chung, Hyun-Kyung

2013-07-01

This report summarizes the proceedings of the third Technical Meeting of the International Code Centres Network held on 6-8 May in 2013. Ten experts from seven member states and four IAEA staff members attended the three-day meeting held at the IAEA Headquarters in Vienna to discuss issues on uncertainty estimates of theoretical atomic and molecular data. The report includes discussions on data issues, meeting conclusions and recommendations for the IAEA Atomic and Molecular Data Unit. (author)

International R&D Spillovers and Marginal Social Returns on R&D

NARCIS (Netherlands)

Sterken, Elmer; Ogawa, Kazuo; Tokutsu, Ichiro

2016-01-01

We analyze the impact of international R&D spillovers on recipient countries in terms of social and private returns. We divide the aggregate R&D stock by the business, government and education sectors and examine the impact on Total Factor Productivity. We endogenize the accrual of the R&D stocks by

Subsidizing R&D cooperatives

NARCIS (Netherlands)

Hinloopen, J.

2001-01-01

A framework is developed with which the implementation of two commonly used R&D-stimulating policies can be evaluated: providing R&D subsidies and sustaining the formation of R&D cooperatives. Subsidized R&D cooperatives can also be analyzed. The analysis shows that providing R&D subsidies is more

40 CFR 63.11561 - What are my standards and management practices?

Science.gov (United States)

2010-07-01

... standards and management practices? (a) For asphalt processing operations, you must meet the emission limits... 40 Protection of Environment 14 2010-07-01 2010-07-01 false What are my standards and management practices? 63.11561 Section 63.11561 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

The Third International Genomic Medicine Conference (3rd IGMC, 2015: overall activities and outcome highlights

Directory of Open Access Journals (Sweden)

Muhammad Abu-Elmagd

2016-10-01

Full Text Available Abstract The Third International Genomic Medicine Conference (3rd IGMC was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA. This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1st IGMC, 2011 followed by the second International Genomic Medicine Conference (2nd IGMC, 2013. The 3rd IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.

R&D 100 Awards | NREL

Science.gov (United States)

R&D 100 Awards R&D 100 Awards NREL has won 61 R&D 100 Awards. Widely recognized as the Oscars of Invention, the R&D 100 Awards are presented by R&D Magazine to identify and celebrate the top technological advances of the year. Recent R&D 100 Awards 2016 NREL engineers Chuck Booten

40 CFR 63.1013 - Sampling connection systems standards.

Science.gov (United States)

2010-07-01

... process fluid to a control device that meets the requirements of § 63.1015; or (4) Collect, store, and... permitted, licensed, or registered by a State to manage municipal or industrial solid waste, if the process...

Status of R&D activity for ITER ICRF power source system

International Nuclear Information System (INIS)

Mukherjee, Aparajita; Trivedi, Rajesh; Singh, Raghuraj; Rajnish, Kumar; Machchhar, Harsha; Ajesh, P.; Suthar, Gajendra; Soni, Dipal; Patel, Manoj; Mohan, Kartik; Hari, J.V.S.; Anand, Rohit; Verma, Sriprakash; Agarwal, Rohit; Jha, Akhil; Kazarian, Fabienne; Beaumont, Bertrand

2015-01-01

Highlights: • R&D program to establish high power RF technology for ITER ICRF source is described. • R&D RF source is being developed using Diacrode & Tetrode technologies. • Test rig (3 MW/3600 s/35–65 MHz) simulating plasma load is developed. - Abstract: India is in-charge for the procurement of ITER Ion Cyclotron Resonance Frequency (ICRF) sources (1 Prototype + 8 series units) along with auxiliary power supplies and Local Control Unit. As there is no unique amplifier chain able to meet the output power specifications as per ITER requirement (2.5 MW per source at 35–65 MHz/CW/VSWR 2.0), two parallel three-stage amplifier chains along with a combiner circuit on the output side is considered. This kind of RF source will be unique in terms of its stringent specifications and building a first of its kind is always a challenge. An R&D phase has been initiated for establishing the technology considering single amplifier chain experimentation (1.5 MW/35–65 MHz/3600 s/VSWR 2.0) prior to Prototype and series production. This paper presents the status of R&D activity to resolve technological challenges involved and various infrastructures developed at ITER-India lab to support such operation.

Status of R&D activity for ITER ICRF power source system

Energy Technology Data Exchange (ETDEWEB)

Mukherjee, Aparajita, E-mail: aparajita.mukherjee@iter-india.org [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar–382428 (India); Trivedi, Rajesh; Singh, Raghuraj; Rajnish, Kumar; Machchhar, Harsha; Ajesh, P.; Suthar, Gajendra; Soni, Dipal; Patel, Manoj; Mohan, Kartik; Hari, J.V.S.; Anand, Rohit; Verma, Sriprakash; Agarwal, Rohit; Jha, Akhil [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar–382428 (India); Kazarian, Fabienne; Beaumont, Bertrand [ITER Organization, CS 90 046, 13067 Sain-Paul-Les-Durance (France)

2015-10-15

Highlights: • R&D program to establish high power RF technology for ITER ICRF source is described. • R&D RF source is being developed using Diacrode & Tetrode technologies. • Test rig (3 MW/3600 s/35–65 MHz) simulating plasma load is developed. - Abstract: India is in-charge for the procurement of ITER Ion Cyclotron Resonance Frequency (ICRF) sources (1 Prototype + 8 series units) along with auxiliary power supplies and Local Control Unit. As there is no unique amplifier chain able to meet the output power specifications as per ITER requirement (2.5 MW per source at 35–65 MHz/CW/VSWR 2.0), two parallel three-stage amplifier chains along with a combiner circuit on the output side is considered. This kind of RF source will be unique in terms of its stringent specifications and building a first of its kind is always a challenge. An R&D phase has been initiated for establishing the technology considering single amplifier chain experimentation (1.5 MW/35–65 MHz/3600 s/VSWR 2.0) prior to Prototype and series production. This paper presents the status of R&D activity to resolve technological challenges involved and various infrastructures developed at ITER-India lab to support such operation.

75 FR 54092 - North Pacific Fishery Management Council; Public Meeting

Science.gov (United States)

2010-09-03

... 28th, 2010 at the Anchorage Hilton Hotel. DATES: The meeting will be held on September 28, 2010, from 9 a.m. to 5 p.m. ADDRESSES: The meeting will be held at the Anchorage Hilton Hotel, 500 West 3rd...

Educational Activity for the Radiation Emergency System in the Northern Part of Japan: Meeting Report on "The 3rd Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2016".

Science.gov (United States)

Matsuya, Yusuke; Tsujiguchi, Takakiyo; Yamaguchi, Masaru; Kimura, Takaaki; Mori, Ryosuke; Yamada, Ryota; Saga, Ryo; Fujishima, Yohei; Date, Hiroyuki

2017-06-01

In the northern part of Japan, close cooperation is essential in preparing for any possible emergency response to radiation accidents because several facilities, such as the Low-Level Radioactive Waste Disposal Facility, the MOX Fuel Fabrication Plant and the Vitrified Waste Storage Center, exist in Rokkasho Village (Aomori Prefecture). After the accident at Fukushima Daiichi Nuclear Power Plant in 2011, special attention should be given to the relationship between radiation and human health, as well as establishing a system for managing with a radiation emergency. In the area of Hokkaido and Aomori prefectures in Japan, since 2008 an exchange meeting between Hokkaido University and Hirosaki University has been held every year to have opportunities to discuss radiation effects on human health and to collect the latest news on monitoring environmental radiation. This meeting was elevated to an international meeting in 2014 titled "Educational Symposium on Radiation and Health (ESRAH) by Young Scientists". The 3rd ESRAH meeting took place in 2016, with the theme "Investigating Radiation Impact on the Environmental and Health". Here we report the meeting findings on the continuing educational efforts after the Fukushima incident, what was accomplished in terms of building a community educational approaches, and future goals.

Offshoring R&D

DEFF Research Database (Denmark)

Hansen, Zaza Nadja Lee; Rasmussen, Lauge Baungaard

2010-01-01

Companies are increasingly offshoring R&D activities. Many firms, however, experience difficulties related to virtual teamwork across cultures and time zones. The research question is: How does increasing R&D offshoring impact transparency of communication structures and knowledge sharing? Using...... case studies from Danish multinational corporations with R&D activities in China, India or Eastern Europe this paper analyses the impact observed in these companies in regard to communication structures and knowledge sharing in management of offshored R&D activities. The findings show that companies...... attempt to increase transparency through formalisation of knowledge and clear communication structures. However, the influence of tacit knowledge, horizontal communication and culture seem largely overlooked. Therefore the authors suggest a context based approach to transparency accustomed...

40 CFR 63.4890 - What emission limits must I meet?

Science.gov (United States)

2010-07-01

... organic HAP-free coating technology can be used on the metal furniture components. The request must be... Standards for Hazardous Air Pollutants: Surface Coating of Metal Furniture Emission Limitations § 63.4890... emission limit for specific metal furniture components or type of components for which you believe the...

23rd Workshop of the Italian Neural Networks Society (SIREN)

CERN Document Server

Esposito, Anna; Morabito, Francesco

2014-01-01

This volume collects a selection of contributions which has been presented at the 23rd Italian Workshop on Neural Networks, the yearly meeting of the Italian Society for Neural Networks (SIREN). The conference was held in Vietri sul Mare, Salerno, Italy during May 23-24, 2013. The annual meeting of SIREN is sponsored by International Neural Network Society (INNS), European Neural Network Society (ENNS) and IEEE Computational Intelligence Society (CIS). The book – as well as the workshop-  is organized in two main components, a special session and a group of regular sessions featuring different aspects and point of views of artificial neural networks, artificial and natural intelligence, as well as psychological and cognitive theories for modeling human behaviors and human machine interactions, including Information Communication applications of compelling interest.  .

Internationalisation of R&D

DEFF Research Database (Denmark)

Haakonsson, Stine Jessen; Ujjual, Vandana

2015-01-01

study of a global firm from the most globalised industry in terms of R&D, biotechnology. The article investigates dynamics of internationalisation of R&D in global networks by looking at: 1) the strategic drivers of location, either as a large potential market or as a pool of competencies; and 2......) the evolution of the company and its R&D activities into emerging market locations: India, China and Brazil. Together, these two dimensions constitute the drivers of R&D internationalisation and contribute to the construction of global innovation networks through knowledge augmenting and exploiting strategies....... The article shows how multinational enterprises can use a combination of augmenting and exploiting strategies in emerging markets and hence demonstrates that international R&D activities not always evolve in a sequential and ordered trajectory....

Domestic R&D and Offshoring

DEFF Research Database (Denmark)

Junge, Martin; Sørensen, Anders

2017-01-01

survey and register data. No evidence is found for a lower probability of own R&D after offshoring takes place compared to before. Moreover, offshoring does not lead to lower R&D intensity in general. However, firms that offshore R&D activity have larger R&D intensity after offshoring has taken place...

76 FR 39076 - Western Hemisphere Institute for Security Cooperation Board of Visitors; Meeting

Science.gov (United States)

2011-07-05

... Defense (Policy); Department of State; US Northern Command and US Southern Command meeting on December 3rd... DEPARTMENT OF DEFENSE Department of the Army Western Hemisphere Institute for Security Cooperation Board of Visitors; Meeting AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY...

Strategic Planning and the Long-term R&D Plan

International Nuclear Information System (INIS)

Cooley, J.

2015-01-01

The Department of Safeguards of the International Atomic Energy Agency implements a structured strategic planning process to ensure that safeguards will continue to be both effective and efficient in the future. This process provides the Department with a comprehensive and coherent planning framework for the short (2 years), medium (6 years) and long (12 years) term. The Department's suite of planning documents includes a long-term strategic plan and an associated long-term research and development plan as well as a biennial development and implementation support programme. The Department's Long-Term Strategic Plan 2012-2023 addresses the conceptual framework for safeguards implementation, legal authority, technical capabilities (expertise, equipment and infrastructure) and the human and financial resources necessary for Agency verification activities. As research and development (R&D) are essential to meet the safeguards needs of the future, the Department-s Long-Term R&D Plan 2012-2023 is designed to support the Long-Term Strategic Plan 2012-2023 by setting out the capabilities that the Department needs to achieve its strategic objectives, and key milestones towards achieving those capabilities for which Member State R&D support is needed. The Long-Term R&D Plan 2012-2023 addresses the Department's R&D requirements in areas such as safeguards concepts and approaches; detection of undeclared nuclear material and activities; safeguards equipment and communication; information technology, collection, analysis and security; analytical services; new mandates; and training. Long-term capabilities discussed in the presentation include deployed systems (e.g., equipment at facilities); analytical (e.g., sample analysis), operational (e.g., staff expertise and skills) and readiness (e.g., safeguarding new types of facilities) capabilities. To address near-term development objectives and support the implementation of its verification activities as well as to

R&D INVESTMENTS AND SPILLOVERS UNDER ENDOGENOUS ABSORPTIVE CAPACITY: COMPETITIVE R&D CANNOT TAKE FULL-ADVANTAGE OF COMPLEMENTARITY IN ABSORPTIVE CAPACITY WHILE COOPERATIVE R&D CAN

Directory of Open Access Journals (Sweden)

Mário A.P.M. Da Silva

2018-03-01

Full Text Available We show that the setting up of general conditions on complementarity in absorptive capacity gives rise to different, if not opposite Nash equilibrium outcomes to those found when absorptive capacity is assumed to be determined only by the similarity of R&D orientations. Firms that cooperate in R&D can take full-advantage of complementarity in R&D by adopting firm-specific R&D paths, which appears to contradict findings and predictions of existing theoretical literature on R&D and spillovers. Oddly, firms competing in R&D cannot gain the most from the potential of complementarity in knowledge by not choosing firm-specific R&D approaches in equilibrium under even milder conditions, which is contrary to another prediction of existing related models.

Interagency Advanced Power Group (IAPG) meeting compendium. October 1991--December 1992

Energy Technology Data Exchange (ETDEWEB)

1993-01-01

Under the direction of the Interagency Advanced Power Group (IAPG), the Power Information Center (PIC) provides support services for each IAPG information exchange session. IAPG members meet a minimum of once each year to share programmatic and technical information on federally funded research and development (R&D) projects in the area of advanced power. This R&D is directed by one of the five IAPG member agencies-the US Army, US Navy, US Air Force, US Department of Energy, and the National Aeronautics and Space Administration. Affiliated Federal groups and federally funded research and development centers can also participate. To enhance the exchange of information between Government researchers, this 1992 IAPG Meeting Compendium has been assembled. This publication is a re-printing of abstracts of each IAPG presentation offered during 1991-1992. The information is arranged chronologically by IAPG meeting. During the 1992 IAPG meeting year, there were presentations restricted to Government audiences only. These ``Restricted`` minutes have not been included in this compilation.

Reviewing R&D Policies

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

Energy security, environmental protection and economic prosperity all pose major challenges for today's energy decision makers. To meet these challenges, innovation, the adoption of new cost-effective technologies, and better use of existing energy-efficient technologies are key elements. The world is not on course for a sustainable energy future -- with security concerns and CO2 emissions projected to more than double by 2050. But this alarming outlook can be changed. A recent major IEA analysis ''Energy Technology Perspectives -- Scenarios and Strategies to 2050'' (IEA, 2006) demonstrate that by developing and employing technologies that already exist or are under development, the world could be brought onto a much more sustainable energy path. The costs of achieving a more sustainable energy future are not disproportionate, but they will require substantial effort and investment by both the public and private sectors. There will be significant additional transitional costs related to RD&D and deployment programmes to commercialise many of the technologies over the next couple of decades.

The 23rd Stirling Physics Meeting

Science.gov (United States)

1998-01-01

derived from a standard Tesla coil with a high-Q secondary. This is capable of delivering around a million volts, which produce fantastic lightning flashes. A volunteer from the audience was invited to enter a huge Faraday Cage which was then subjected to these high voltage sparks! For a while the door of the cage jammed but eventually the victim emerged unscathed! This is, of course, not just an entertainment. The Gusto show is taken into schools and targeted at lower secondary pupils about to make their subject choices. The team also gives large scale physics demonstration lectures and could play to 10 000 children in a month. So physics is fun and physics is relevant to everyday life! Support for physics teachers Lesley Glasser chaired the afternoon session, which she opened by introducing the Institute's Education Officer. The Stirling Meeting would not be the same without the `commercial slot' presented again so ably by Catherine Wilson. Physics teachers are an endangered species and the Institute is determined to do whatever it can to support them. Plans are afoot to make sure the Schools Lectures are modified, if necessary, to take account of the educational differences in Scotland. The London-based `Physics in Perspective' course not only introduces sixth-formers to some of the frontiers of physics but gives enough free time for them to visit places of interest in the city - from the Science Museum to Soho. `So they associate physics with enjoyment!' Another Scottish Update Course is planned for teachers, and a brand new glossy booklet, sent free to all schools, will show pupils that choosing physics is a `Smart Move'. Finally the Institute has just started a major post-16 curriculum project which will include a variety of support materials to keep teachers abreast of continuing developments in physics. Each year, IoP Teacher of Physics Awards are given to `outstanding teachers of physics who inspire others to continue with and enjoy their physics'. Ann Jarvie

78 FR 72929 - Sunshine Act Meeting

Science.gov (United States)

2013-12-04

... DEPARTMENT OF JUSTICE Parole Commission Sunshine Act Meeting TIME AND DATE: 12:00 p.m., Tuesday, December 10, 2013. PLACE: U.S. Parole Commission, 90 K Street NE., 3rd Floor, Washington, DC. STATUS: Closed. MATTERS TO BE CONSIDERED: Determination on four original jurisdiction cases. CONTACT PERSON FOR...

RD39 Status Report 2009

CERN Document Server

Anbinderis, P; Bates, R; Bol, H; Buttar, C; Chen, W; Cindro, V; de Boer, W; Eremin, V; Gaubas, E; Grigoriev, E; Härkönen, J; Heijne, E; Heising, S; Ilyashenko, I; Kalesinskas, V; Krause, M; Li, Z; Luukka, P; Mäenpää, T; Mandi, I; Mikuz, M; Mueller, S; Niinikoski, T; O'Shea, V; Parkes, C; Pusa, P; Räisänen, J; Reinhardt, S; Spiegel, L; Tuominen, E; Tuovinen, E; Vaitkus, J; Väyrynen, S; Verbitskaya, E; Zavrtanik, M; CERN. Geneva. The LHC experiments Committee; LHCC

2010-01-01

RD39 Status Report 2009. CERN RD39 Collaboration is developing super-radiation hard cryogenic silicon detectors for applications of LHC experiments and their future upgrades. The activities of RD39 Collaboration were focused in 2009 on concept of charge injected detector (CID).

43rd Plenary Meeting Report of the Scientific, Technical and Economic Committee for Fisheries (PLEN-13-01)

DEFF Research Database (Denmark)

Casey, J.; Abella, J. A.; Andersen, J.

The Scientific, Technical and Economic Committee for Fisheries hold its 43rd plenary on 8-12 July 2013 in Brussels (Belgium). The terms of reference included both issues assessments of STECF Expert Working Group reports and additional requests submitted to the STECF by the Commission. Topics deal...... were inter alia assessments of the economic performance of the EU fishing fleet, fishing effort regime evaluations, future EU data collection, and review of stock advice.......The Scientific, Technical and Economic Committee for Fisheries hold its 43rd plenary on 8-12 July 2013 in Brussels (Belgium). The terms of reference included both issues assessments of STECF Expert Working Group reports and additional requests submitted to the STECF by the Commission. Topics dealt...

Conferences in historical geography – traditional interdisciplinary meetings

Czech Academy of Sciences Publication Activity Database

Semotanová, Eva; Chodějovská, Eva; Šimůnek, Robert

2012-01-01

Roč. 38, č. 1 (2012), s. 222-227 ISSN 0323-0988 R&D Projects: GA ČR(CZ) GBP410/12/G113 Institutional support: RVO:67985963 Keywords : history * historical geography * interdisciplinary meetings Subject RIV: AB - History

Determinants of Firm R&D

DEFF Research Database (Denmark)

Tingvall, Patrick Gustavsson; Poldahl, Andreas

2012-01-01

Research and Development (R&D) is a key component behind technological development and economic growth; therefore, understanding the drivers of R&D is crucial. An interesting question is the role of technology spillovers, transferred by trade, and their impact on firm R&D. Here we analyze not only...

RD50 Prolongation Request 2018

CERN Document Server

Casse, Gianluigi

2018-01-01

With this document, we request the prolongation of the CERN RD50 research program for 5 years. A very brief historical review of the RD50 research program since the RD50 project approval by the Research Board in the year 2002 is presented and the biggest RD50 achievements are highlighted. The present composition of the collaboration, its organizational structure, and the research methodology are described. The role of RD50 in the present various upgrade and research programs of the LHC Experiments community is given and the overall work plan explained. Finally, a detailed 5-years work program with precise milestones and deliverables for the various research activities is presented. We conclude with our prolongation request towards the LHCC.

Prospective benefits analysis of the DOE Nuclear Energy portfolio: NE R&D program data assumptions, approach, & results

Energy Technology Data Exchange (ETDEWEB)

Bhatt, Vatsal [Brookhaven National Lab. (BNL), Upton, NY (United States); Friley, Paul [Brookhaven National Lab. (BNL), Upton, NY (United States); Lee, John [Brookhaven National Lab. (BNL), Upton, NY (United States); Reisman, Ann [Brookhaven National Lab. (BNL), Upton, NY (United States)

2006-10-31

The Office of Nuclear Energy (NE) leads the U.S. Government’s efforts to develop new nuclear energy generation technologies to meet energy and climate goals, and to develop advanced proliferation-resistant nuclear fuel technologies that maximize energy from nuclear fuel; contributes to the R&D for a possible transition to a hydrogen economy; and maintains and enhances the national nuclear technology infrastructure. NE serves the present and future energy needs of the Nation by managing the safe operation and maintenance of the Department of Energy (DOE) critical nuclear in frastructure, providing nuclear technology goods and services, and conducting R&D.

40 CFR 63.1581 - Does the subpart distinguish between different types of POTW treatment plants?

Science.gov (United States)

2010-07-01

... different types of POTW treatment plants? 63.1581 Section 63.1581 Protection of Environment ENVIRONMENTAL... treatment plants? Yes, POTW treatment plants are divided into two subcategories. A POTW treatment plant which does not meet the characteristics of an industrial POTW treatment plant belongs in the non...

25 CFR 63.5-63.9 - [Reserved

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false [Reserved] 63.5-63.9 Section 63.5-63.9 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Purpose, Policy, and Definitions §§ 63.5-63.9 [Reserved] ...

Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice.

Science.gov (United States)

Mitton, Kenneth P; Guzman, Alvaro E; Deshpande, Mrinalini; Byrd, David; DeLooff, Camryn; Mkoyan, Kristina; Zlojutro, Paul; Wallace, Adrianne; Metcalf, Brandon; Laux, Kirsten; Sotzen, Jason; Tran, Trung

2014-01-01

The histone-deacetylase inhibitor activity of valproic acid (VPA) was discovered after VPA's adoption as an anticonvulsant. This generated speculation for VPA's potential to increase the expression of neuroprotective genes. Clinical trials for retinitis pigmentosa (RP) are currently active, testing VPA's potential to reduce photoreceptor loss; however, we lack information regarding the effects of VPA on available mammalian models of retinal degeneration, nor do we know if retinal gene expression is perturbed by VPA in a predictable way. Thus, we examined the effects of systemic VPA on neurotrophic factor and Nrl-related gene expression in the mouse retina and compared VPA's effects on the rate of photoreceptor loss in two strains of mice, Pde6b(rd1/rd1) and Pde6b(rd10/rd10) . The expression of Bdnf, Gdnf, Cntf, and Fgf2 was measured by quantitative PCR after single and multiple doses of VPA (intraperitoneal) in wild-type and Pde6b(rd1/rd1) mice. Pde6b(rd1/rd1) mice were treated with daily doses of VPA during the period of rapid photoreceptor loss. Pde6b(rd10/rd10) mice were also treated with systemic VPA to compare in a partial loss-of-function model. Retinal morphology was assessed by virtual microscopy or spectral-domain optical coherence tomography (SD-OCT). Full-field and focal electroretinography (ERG) analysis were employed with Pde6b(rd10/rd10) mice to measure retinal function. In wild-type postnatal mice, a single VPA dose increased the expression of Bdnf and Gdnf in the neural retina after 18 h, while the expression of Cntf was reduced by 70%. Daily dosing of wild-type mice from postnatal day P17 to P28 resulted in smaller increases in Bdnf and Gdnf expression, normal Cntf expression, and reduced Fgf2 expression (25%). Nrl gene expression was decreased by 50%, while Crx gene expression was not affected. Rod-specific expression of Mef2c and Nr2e3 was decreased substantially by VPA treatment, while Rhodopsin and Pde6b gene expression was normal at P28. Daily

Proceedings of the joint Nordic spring meeting '92

International Nuclear Information System (INIS)

Lindgaard, P.-A.

1992-05-01

Proceedings in the form of extended abstracts of the Joint Nordic Spring Meeting '92 including the 3rd Nordic Conference on Surface Science, the 6th Nordic Symposium on Computer Simulation, and 3rd Nordic Symposium on Superconductivity. In addition there are contributions from workshops on the Physics of Small Cluster, on Soft Condensed Matter Physics and from an Electronic Properties Workshop. The proceedings constrain over 300 contributions on the mentioned subjects. Further, there are several contributions on general solid state subjects, magnetism, semiconductors etc. (au) (4 tabs., 187 ills., 931 refs.)

63rd German radiological congress

International Nuclear Information System (INIS)

1982-01-01

The book of abstracts contains abstracts of 171 papers read at the German Radiological Congress in Berlin as well as abstracts of two papers not read for lack of time. Further, there are 31 brief descriptions of the scientific exhibition. Subjects: Diagnosis of gall bladder diseases and inflammatory diseases of the large intestine; hyperthermia and irradiation in tumour therapy; nuclear methods in the diagnosis of growing and displacing processes, skeletal diseases, thromboses, embolisms, gastrointestinal and liver affections; new techniques and methods, diagnostics of the spinal tract; radiooncology; carcinoma of the ovaries; diagnostics and therapy of tumours of the lungs; computerized tomography; angiography; ultrasonic diagnosis. (MG) [de

Property (RD) for Hecke Pairs

International Nuclear Information System (INIS)

Shirbisheh, Vahid

2012-01-01

As the first step towards developing noncommutative geometry over Hecke C ∗ -algebras, we study property (RD) (Rapid Decay) for Hecke pairs. When the subgroup H in a Hecke pair (G, H) is finite, we show that the Hecke pair (G, H) has (RD) if and only if G has (RD). This provides us with a family of examples of Hecke pairs with property (RD). We also adapt Paul Jolissant’s works in Jolissaint (J K-Theory 2:723–735, 1989; Trans Amer Math Soc 317(1):167–196, 1990) to the setting of Hecke C ∗ -algebras and show that when a Hecke pair (G, H) has property (RD), the algebra of rapidly decreasing functions on the set of double cosets is closed under holomorphic functional calculus of the associated (reduced) Hecke C ∗ -algebra. Hence they have the same K 0 -groups.

40 CFR 63.11086 - What requirements must I meet if my facility is a bulk gasoline plant?

Science.gov (United States)

2010-07-01

... facility is a bulk gasoline plant? 63.11086 Section 63.11086 Protection of Environment ENVIRONMENTAL... Source Category: Gasoline Distribution Bulk Terminals, Bulk Plants, and Pipeline Facilities Emission... gasoline plant? Each owner or operator of an affected bulk gasoline plant, as defined in § 63.11100, must...

ATLAS Cloud R&D

CERN Document Server

Panitkin, S; The ATLAS collaboration; Caballero Bejar, J; Benjamin, D; DiGirolamo, A; Gable, I; Hendrix, V; Hover, J; Kucharczuk, K; Medrano LLamas, R; Love, P; Ohman, H; Paterson, M; Sobie, R; Taylor, R; Walker, R; Zaytsev, A

2014-01-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained...

Proceedings of the natural gas RD&D contractors review meeting, Volume I

Energy Technology Data Exchange (ETDEWEB)

Malone, R.D.

1995-04-01

This report contains papers which were presented at the natural gas contractors review meeting held on April 4-6, 1995. Topics were concerned with resource and reserves, low permeability reservoir characterization, natural fracture detection, drilling, completion, and stimulation, and natural gas upgrading. Individual papers were processed separately for the United States Department of Energy databases.

43rd Aerospace Mechanisms Symposium

Science.gov (United States)

Boesiger, Edward A.

2016-01-01

The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Sponsored and organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 43rd symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 43rd AMS was held in Santa Clara, California on May 4, 5 and 6, 2016. During these three days, 42 papers were presented. Topics included payload and positioning mechanisms, components such as hinges and motors, CubeSats, tribology, and mechanism testing. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The high quality of this symposium is a result of the work of many people, and their efforts are gratefully acknowledged. This extends to the voluntary members of the symposium organizing committee representing the eight NASA field centers, LMSSC, and the European Space Agency. Appreciation is also extended to the session chairs, the authors, and particularly the personnel at ARC responsible for the symposium arrangements and the publication of these proceedings. A sincere thank you also goes to the symposium executive committee who is responsible for the year-to-year management of the AMS, including paper processing and preparation of the program. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration.

78 FR 69431 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

Science.gov (United States)

2013-11-19

... Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. The meetings will.... to 10:00 a.m. Agenda: To review and evaluate grant applications. Place: Georgetown University Hotel... University Hotel and Conference Center, 3800 Reservoir Rd. NW., Washington, DC 20057. Contact Person: William...

The returns to foreign R&D

NARCIS (Netherlands)

Belderbos, R.A.; Lokshin, B.; Sadowski, B.

2015-01-01

Extant research on R&D internationalization has not examined how effective foreign R&D investments are in generating positive returns for the investing firms, in particular in comparison and conjunction with the effects of domestic R&D investments. We examine the effectiveness of international

40 CFR 63.7790 - What emission limitations must I meet?

Science.gov (United States)

2010-07-01

...) For each venturi scrubber applied to meet any particulate emission limit in Table 1 to this subpart, you must maintain the hourly average pressure drop and scrubber water flow rate at or above the... other than a baghouse, venturi scrubber, or electrostatic precipitator must submit a description of the...

Crowdsourced 'R&D' and medical research.

Science.gov (United States)

Callaghan, Christian William

2015-09-01

Crowdsourced R&D, a research methodology increasingly applied to medical research, has properties well suited to large-scale medical data collection and analysis, as well as enabling rapid research responses to crises such as disease outbreaks. Multidisciplinary literature offers diverse perspectives of crowdsourced R&D as a useful large-scale medical data collection and research problem-solving methodology. Crowdsourced R&D has demonstrated 'proof of concept' in a host of different biomedical research applications. A wide range of quality and ethical issues relate to crowdsourced R&D. The rapid growth in applications of crowdsourced R&D in medical research is predicted by an increasing body of multidisciplinary theory. Further research in areas such as artificial intelligence may allow better coordination and management of the high volumes of medical data and problem-solving inputs generated by the crowdsourced R&D process. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Where Library History Meets the Future: Proceedings of the 43rd Annual Military Librarians Workshop

Science.gov (United States)

2001-04-04

virtual library study earlier this year (“Virtual Libraries: Meeting the Corporate Challenge,” March 1, 1999) users regret the loss of thinking/meeting...buildings of historic Colonial Williamsburg. Lastly, libraries and librarianship are at a time in their evolution that propels them forward. Libraries...buildings of historic Colonial Williamsburg. Lastly, libraries and librarianship are at a time in their evolution that propels them forward. Libraries

Managing R&D and New Product Development

NARCIS (Netherlands)

von Zedtwitz, Maximilian; Friesike, Sascha; Gassmann, Oliver; Dodgson, Mark; Gann, David M.; Phillips, Nelson

2014-01-01

This article examines the importance of R&D and new product development and explores their management. It describes three central aspects of managing R&D and new product development in firms: the product development funnel, R&D portfolio management, and R&D organization. Concepts such as the ‘fuzzy

Solid-State Lighting R&D Plan - 2016

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-06-30

The SSL R&D Plan provides analysis and direction for ongoing R&D activities to advance SSL technology and increase energy savings. The R&D Plan also reviews SSL technology status and trends for both LEDs and OLEDs and offers an overview of the current DOE SSL R&D project portfolio.

Final report: ES11: The 23rd Annual Workshop on Electronic Structure Methods

Energy Technology Data Exchange (ETDEWEB)

Rappe, Andrew M. [Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Chemistry

2011-08-31

ES11: the 23rd Annual Workshop on Electronic Structure Methods was held from June 6-9, 2011 at the University of Pennsylvania. The local organizing committee (see Section II) led by PI Andrew M. Rappe supervised the organization of the conference, before, during, and after the meeting itself. The national organizing committee set the technical program of talks, and provided support and advice in various ways. The conference was well-attended (see Section III). An important feature of this conference was a series of panel discussions (see Section IV) to discuss the field of electronic structure and to set new directions. The technical program was of extraordinarily high quality (see Section V). The host institution, the University of Pennsylvania, provided a supportive environment for this meeting (see Section VI).

Environmental Assessment of R&D Programmes

DEFF Research Database (Denmark)

Lyhne, Ivar; Byriel, Inger Pihl

2013-01-01

cause severe negative environmental impacts. This paper presents an innovative environmental assessment practice on R&D programmes in Denmark. It reports on the challenges and experiences of assessing the Danish R&D programme ForskEL, which promotes R&D projects within the electricity sector......Despite their important role in shaping the technologies of the future, public research and development (R&D) programmes are rarely based on systematic assessments of the environmental effects. R&D programmes thus allocate a huge amount of financial resources to projects, which potentially may....... The programme is characterised by uncertainty about impacts and incomparable project types and technologies. A methodology for dealing with these challenges is presented, and experiences from a testing of the methodology on the 2012 programme are reflected upon. Finally the assessment is discussed in terms...

Effect of different surface nanoroughness of titanium dioxide films on the growth of human osteoblast-like MG63 cells

Czech Academy of Sciences Publication Activity Database

Vandrovcová, Marta; Hanuš, J.; Drábik, M.; Kylián, O.; Biederman, H.; Lisá, Věra; Bačáková, Lucie

100A, č. 4 (2012), s. 1016-1032 ISSN 1549-3296 R&D Projects: GA AV ČR(CZ) KAN101120701 Institutional research plan: CEZ:AV0Z50110509 Keywords : titanium dioxide * nanoscale surface roughness * MG63 cells Subject RIV: EI - Biotechnology ; Bionics Impact factor: 2.834, year: 2012

Network configuration of global R&D networks

DEFF Research Database (Denmark)

Hansen, Zaza Nadja Lee; Srai, Jagjit Singh

2011-01-01

, network configuration of global R&D has tended to focus on strategic elements with limited attention given operational effectiveness, or to interfaces with downstream manufacturing operations. Within OM literature, the drivers of configuration of global networks within, engineering, production, supply...... to R&D networks emerged, e.g. product features were more prominent in R&D networks. Furthermore, the study has shown extensive interaction with other operations, including many downstream manufacturing operations. By extending the OM configuration concepts to the configuration of R&D networks......Companies are increasingly globalising their R&D activities, both within the firms and with external partners, with consequent implications for their interaction with manufacturing operations. Previous research in R&D networks has focused on coordination, governance and support elements. However...

Report of 6th research meeting on basic process of fuel cycle for nuclear fusion reactors, Yayoi Research Group; 3rd expert committee on research of nuclear fusion fuel material correlation basis

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

In this report, the lecture materials of Yayoi Research Group, 6th research meeting on basic process of fuel cycle for nuclear fusion reactors which was held at the University of Tokyo on March 25, 1996, are collected. This workshop was held also as 3rd expert committee on research of nuclear fusion fuel material correlation basis of Atomic Energy Society of Japan. This workshop has the character of the preparatory meeting for the session on `Interface effect in nuclear fusion energy system` of the international workshop `Interface effect in quantum energy system`, and 6 lectures and one comment were given. The topics were deuterium transport in Mo under deuterium ion implantation, the change of the stratum structure of graphite by hydrogen ion irradiation, the tritium behavior in opposing materials, the basic studies of the irradiation effects of solid breeding materials, the research on the behavior of hydroxyl group on the surface of solid breeding materials, the sweep gas effect on the surface of solid breeding materials, and the dynamic behavior of ion-implanted deuterium in proton-conductive oxides. (K.I.)

Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma.

Science.gov (United States)

Gay, Francesca; Rajkumar, S Vincent; Coleman, Morton; Kumar, Shaji; Mark, Tomer; Dispenzieri, Angela; Pearse, Roger; Gertz, Morie A; Leonard, John; Lacy, Martha Q; Chen-Kiang, Selina; Roy, Vivek; Jayabalan, David S; Lust, John A; Witzig, Thomas E; Fonseca, Rafael; Kyle, Robert A; Greipp, Philip R; Stewart, A Keith; Niesvizky, Ruben

2010-09-01

The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornell Medical Center were retrospectively compared with an equal number of matched pair mates selected among patients seen at the Mayo Clinic who received Rd. Case matching was blinded and was performed according to age, gender, and transplant status. On intention-to-treat analysis, complete response (45.8% vs. 13.9%, P < 0.001) and very-good-partial-response or better (73.6% vs. 33.3%, P < 0.001) were significantly higher with BiRd. Time-to-progression (median 48.3 vs. 27.5 months, P = 0.071), and progression-free survival (median 48.3 vs. 27.5 months, P = 0.044) were higher with BiRd. There was a trend toward better OS with BiRd (3-year OS: 89.7% vs. 73.0%, P = 0.170). Main grade 3-4 toxicities of BiRd were hematological, in particular thrombocytopenia (23.6% vs. 8.3%, P = 0.012). Infections (16.7% vs. 9.7%, P = 0.218) and dermatological toxicity (12.5% vs. 4.2%, P = 0.129) were higher with Rd. Results of this case-matched analysis suggest that there is significant additive value when clarithromycin is added to Rd. Randomized phase III trials are needed to confirm these results. © 2010 Wiley-Liss, Inc.

Evaluating firms' R&D performance using best worst method.

Science.gov (United States)

Salimi, Negin; Rezaei, Jafar

2018-02-01

Since research and development (R&D) is the most critical determinant of the productivity, growth and competitive advantage of firms, measuring R&D performance has become the core of attention of R&D managers, and an extensive body of literature has examined and identified different R&D measurements and determinants of R&D performance. However, measuring R&D performance and assigning the same level of importance to different R&D measures, which is the common approach in existing studies, can oversimplify the R&D measuring process, which may result in misinterpretation of the performance and consequently fallacy R&D strategies. The aim of this study is to measure R&D performance taking into account the different levels of importance of R&D measures, using a multi-criteria decision-making method called Best Worst Method (BWM) to identify the weights (importance) of R&D measures and measure the R&D performance of 50 high-tech SMEs in the Netherlands using the data gathered in a survey among SMEs and from R&D experts. The results show how assigning different weights to different R&D measures (in contrast to simple mean) results in a different ranking of the firms and allow R&D managers to formulate more effective strategies to improve their firm's R&D performance by applying knowledge regarding the importance of different R&D measures. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Strategic management of government-sponsored R&D portfolios

OpenAIRE

Barry Bozeman; Juan Rogers

2001-01-01

Although strategic management of R&D portfolios is common practice in private sector R&D, government R&D management tends to be more discrete and ad hoc, focusing on generating maximum output from individual projects. Often, there is no clear notion of the desired public sector output. Whereas private sector R&D evaluation is generally straightforward, with the function of R&D being measured in terms of a company's internal return on investment, the benefits of public-sponsored R&D tend to be...

ATLAS Cloud R&D

Science.gov (United States)

Panitkin, Sergey; Barreiro Megino, Fernando; Caballero Bejar, Jose; Benjamin, Doug; Di Girolamo, Alessandro; Gable, Ian; Hendrix, Val; Hover, John; Kucharczyk, Katarzyna; Medrano Llamas, Ramon; Love, Peter; Ohman, Henrik; Paterson, Michael; Sobie, Randall; Taylor, Ryan; Walker, Rodney; Zaytsev, Alexander; Atlas Collaboration

2014-06-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained a significant insight into the cloud computing landscape and has identified points that still need to be addressed in order to fully utilize this technology. This contribution will explain the cloud integration models that are being evaluated and will discuss ATLAS' learning during the collaboration with leading commercial and academic cloud providers.

Kokes Award for the 24th North American Catalysis Society Meeting

Energy Technology Data Exchange (ETDEWEB)

Rioux, Robert M. [Pennsylvania State Univ., University Park, PA (United States)

2016-05-02

The objective of the Richard. J. Kokes Travel Award program is to encourage the participation of students in the biennial North American Catalysis Society (NACS) Meetings. The Kokes Award covers a significant portion of the transportation, lodging, and conference registration costs. Eligible students must be enrolled at a North American university and need to present a paper at the meeting. The Kokes awardee will be required to contribute some time to the organizing committee to assist in meeting operations and to be present at the meeting during the entire time. Similar to the 23rd Kokes Award program, undergraduate students are also eligible for the 24th Kokes Award program.

76 FR 17712 - Sunshine Act; Notice Of Agency Meeting

Science.gov (United States)

2011-03-30

... NATIONAL CREDIT UNION ADMINISTRATION Sunshine Act; Notice Of Agency Meeting TIME AND DATE: 9:30 a.m., Monday, April 4, 2011. PLACE: Westin San Diego Hotel, Board Room, 3rd Floor, 400 West Broadway, San Diego, CA 92101. STATUS: Closed. MATTERS TO BE CONSIDERED: 1. Consideration of Supervisory...

Conference Support, 23rd Western Photosynthesis Conference 2014, Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Wachter, Rebekka [Arizona State Univ., Tempe, AZ (United States)

2015-01-12

The Western Photosynthesis Conference is a regional conference that is held on an annual basis to bring together researchers primarily from the Western United States to share their newest research advances on photosynthetic processes. The 23rd conference was focused on both fundamental and more applied research on the biological conversion of solar energy to various energy storage forms. Several particular areas of solar energy conversion were emphasized in this conference (see below). Some of these topics, such as carbon limitations on photosynthesis, biomimicry and phenotyping, have traditionally not been incorporated extensively in the Western Photosynthesis Conference. We found that these topics have substantially broadened of the scope of this meeting.

76 FR 73737 - Sunshine Act Meeting

Science.gov (United States)

2011-11-29

... Meeting) (Tentative) a. U.S. Department of Energy (High-Level Waste Repository), Docket No. 63-001-HLW... Regarding Preservation of Licensing Support Network (LSN) Documents Collection, and Staff Request for Stay... the distribution, please contact the Office of the Secretary, Washington, DC 20555 (301) 415-1969), or...

40 CFR 63.680 - Applicability and designation of affected sources.

Science.gov (United States)

2010-07-01

... separate a mixture of several volatile components of different boiling points in successive stages, each... this subpart based on the composition of the material at the point-of-delivery, as defined in § 63.681... unit that meets the definition of a tank or container but also is equipped with a vent that serves as a...

Captive R&D Offshoring

DEFF Research Database (Denmark)

Søberg, Peder Veng

This PhD thesis includes four journal papers and one book chapter, which investigate how newly established foreign-invested R&D units in emerging markets become able to carry out their mandates. In particular, the author investigates how the employees of such units acquire R&D home base knowledge...... Scandinavia and now operating in Scandinavia, China, and India. The thesis questions an assumption in the Uppsala model, which implies that different business activities can be internationalized in the same way. The findings point to the importance of socialization across the R&D home base and newly...... that the local talent in China and India is particularly suited to improving existing products and processes. However, due to a lack of social initiative, it is more difficult to use this talent to identify and solve entirely new problems. The thesis also investigates how local sources of knowledge are engaged...

The RD53A Integrated Circuit

CERN Document Server

Garcia-Sciveres, Maurice

2017-01-01

Implementation details for the RD53A pixel readout integrated circuit designed by the RD53 Collaboration. This is a companion to the specifications document and will eventually become a reference for chip users. RD53A is not intended to be a final production IC for use in an experiment, and contains design variations for testing purposes, making the pixel matrix non-uniform. The chip size is 20.0 mm by 11.8 mm.

Are there Diminishing Returns to R&D?

DEFF Research Database (Denmark)

Madsen, Jakob B.

Semi-endogenous models and, to some extent, also Schumpeterian models are based on the assumption of diminishing returns to R&D. This paper shows that the null hypothesis of constant returns to R&D cannot be rejected for the OECD countries......Semi-endogenous models and, to some extent, also Schumpeterian models are based on the assumption of diminishing returns to R&D. This paper shows that the null hypothesis of constant returns to R&D cannot be rejected for the OECD countries...

EU-US differences in the size of R&D intensive firms : Do they explain the overall R&D intensity gap?

NARCIS (Netherlands)

Ortega Argiles, Raquel; Brandsma, Andries

The average firm size of the top R&D investors among US-based companies is smaller than that of the EU-based firms. Does this help to explain why the US has a greater R&D intensity, or is the greater firm size in the EU, just as its lower R&D intensity, determined by the sectors in which the top R&D

RD53A Integrated Circuit Specifications

CERN Document Server

Garcia-Sciveres, Mauricio

2015-01-01

Specifications for the RD53 collaboration’s first engineering wafer run of an integrated circuit (IC) for hybrid pixel detector readout, called RD53A. RD53A is intended to demonstrate in a large format IC the suitability of the technology (including radiation tolerance), the stable low threshold operation, and the high hit and trigger rate capabilities, required for HL-LHC upgrades of ATLAS and CMS. The wafer scale production will permit the experiments to prototype bump bonding assembly with realistic sensors in this new technology and to measure the performance of hybrid assemblies. RD53A is not intended to be a final production IC for use in an experiment, and will contain design variations for testing purposes, making the pixel matrix non-uniform.

Variable-Base Budgeting for R&D

OpenAIRE

Robert W. Blanning

1981-01-01

An issue of theoretical and practical importance to R&D managers is the proper allocation of an organization's resources between the periodic selection and budgeting of R&D projects and the implementation of these projects. One possibility is to consider previous allocations as an established base and to restrict the attention of R&D managers to an examination of any subsequent deviations from the base. The advantage of this strategy, often called incremental budgeting, is that it focuses man...

Optimal R&D Investments of the Firm

NARCIS (Netherlands)

Kort, P.M.

1996-01-01

This paper examines irreversible decisions on innovative activities where it takes time to complete an R&D project. The totala mountof R&D investments that the firm needs to undertake in order to obtain the breakthrough in the innovation process is uncertain. R&D investments are limited by the

33rd annual technical meeting of the Petroleum Society of CIM

Energy Technology Data Exchange (ETDEWEB)

1982-03-01

This meeting report of a conference on 'Energy Self-Sufficiency: Dream or Reality.' to be held in Calgary June 6-9, 1982 gives details of the program and contains abstracts of the 99 papers. Ten of these concern coal. Topics include temperature and cavity configuration modelling associated with moving boundary in underground coal conversion; modelling of underground coal gasification; coal liquefaction heat transfer coefficients; viscosity of coal-bitumen and coal-anthracene oil slurries; economic extraction of methane through coal demethanation; coal and solid waste burning Stirling engines; Canadian program for underground coal conversion; effect of moisture on the behaviour of shales and roof bolt anchoring capacity; effect of weak floor interaction on stability of coal pillars; and pressures in coal silos.

The 3rd Nordic meeting on high energy reactions in nuclei

International Nuclear Information System (INIS)

Green, A.M.; Kullander, S.

Abstracts of the 31 lectures given at the meeting are presented. Major emphasis was placed on the nucleon-nucleon and nucleon-antinucleon interaction in bound and unbound systems. Four of the ten sessions were devoted to this subject. Two sessions contained lecture and seminars on 'Isobars in nuclei', two were devoted to hadron-nucleus reactions, one to high-energy heavy-ion reactions and one to new developments of experimental tools. This latter session had two talks, one about channeling with GeV particles and the other about the planned low-energy antiproton facility LEAR at CERN. Talks of more general character were 'The experimental programme at the CERN SC', 'Accelerator produced nuclear fuel' and 'The upsilons, a new family of quark-antiquark bound state'. (JIW)

Treatment Algorithm for the Hypertension Specialist after the Milan Meeting in 2007

Czech Academy of Sciences Publication Activity Database

Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana

2007-01-01

Roč. 30 (2007), s. 374-374 ISSN 1420-4096. [Central European Meeting on Hypertension and Cardiovascular Disease Prevention. 11.10.2007-13.10.2007, Kraków] R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : hypertension specialist * treatment algorithm for the hypertension * treatment after the Milan Meeting in 2007 Subject RIV: FA - Cardiovascular Disease s incl. Cardiotharic Surgery

Agricultural R&D, technology and productivity.

Science.gov (United States)

Piesse, J; Thirtle, C

2010-09-27

The relationships between basic and applied agricultural R&D, developed and developing country R&D and between R&D, extension, technology and productivity growth are outlined. The declining growth rates of public R&D expenditures are related to output growth and crop yields, where growth rates have also fallen, especially in the developed countries. However, growth in output value per hectare has not declined in the developing countries and labour productivity growth has increased except in the EU. Total factor productivity has generally increased, however it is measured. The public sector share of R&D expenditures has fallen and there has been rapid concentration in the private sector, where six multinationals now dominate. These companies are accumulating intellectual property to an extent that the public and international institutions are disadvantaged. This represents a threat to the global commons in agricultural technology on which the green revolution has depended. Estimates of the increased R&D expenditures needed to feed 9 billion people by 2050 and how these should be targeted, especially by the Consultative Group on International Agricultural Research (CGIAR), show that the amounts are feasible and that targeting sub-Saharan Africa (SSA) and South Asia can best increase output growth and reduce poverty. Lack of income growth in SSA is seen as the most insoluble problem.

77 FR 40325 - Agenda and Notice of Public Meeting of the North Dakota Advisory Committee

Science.gov (United States)

2012-07-09

.... Commission on Civil Rights, and the Federal Advisory Committee Act (FACA), that a planning meeting of the..., at the River Room, Fargo City Hall, 200 N. 3rd Street, Fargo, ND 58102. The purpose of the planning... street address. Deaf or hearing-impaired persons who will attend the meeting and require the services of...

RD53A Integrated Circuit Specifications

OpenAIRE

Garcia-Sciveres, Mauricio

2015-01-01

Specifications for the RD53 collaboration’s first engineering wafer run of an integrated circuit (IC) for hybrid pixel detector readout, called RD53A. RD53A is intended to demonstrate in a large format IC the suitability of the technology (including radiation tolerance), the stable low threshold operation, and the high hit and trigger rate capabilities, required for HL-LHC upgrades of ATLAS and CMS. The wafer scale production will permit the experiments to prototype bump bonding assembly with...

R&D and Price Elasticity of Demand

DEFF Research Database (Denmark)

Lucke, D.; Schröder, Philipp; D., Schumacher,

2004-01-01

This paper explores the relationship between the price elasticity of demand and the R&D intensity of the product. We introduce the concept of R&D intensity into a standard Dixit-Stiglitz/Krugman-type setting. R&D activity is treated as a fixed cost of production. Within this framework, sectors...... with a higher R&D intensity show a lower price elasticity of demand. This proposition is confirmed by an empirical investigation of export demand for manufactured goods from major industrialised countries. Consequently, real exchange rate changes have an impact on the commodity structure of exports....

R&D 100 Awards Honor NREL Research

Science.gov (United States)

R&D 100 Awards Honor NREL Research For more information contact: George Douglas 303-275-4096 e National Renewable Energy Laboratory will be honored Thursday with two R&D 100 awards. The awards are given each year by the editors of R&D Magazine for what they consider to be among the year's 100

Investigating investment in biopharmaceutical R&D

Science.gov (United States)

Carter, Percy H.; Berndt, Ernst R.; DiMasi, Joseph A.; Trusheim, Mark

2016-01-01

Recent studies have highlighted a reduction in projected financial returns associated with biopharmaceutical R&D, owing to decreased productivity, increases in costs and flattening revenue per new drug, prompting calls for dramatic revisions to R&D models. On the basis of previous financial modelling, the simplest hypothesis would be that new investment in such R&D should be minimal and focused on biologics in preference to small molecules, as the internal rate of return on investment for biologics projects has been reported to be higher. PMID:27616295

Design of polymer networks by variation of precursor structure and crosslinking regime

Czech Academy of Sciences Publication Activity Database

Dušek, Karel; Dušková, Miroslava; Huybrecht, J.

2003-01-01

Roč. 44, č. 1 (2003), s. 62-63 ISSN 0032-3934. [ACS National Meeting "Crosslinking Materials and Processes"/254./. New Orleans, 23.03.2003-27.03.2003] R&D Projects: GA AV ČR KSK4050111 Keywords : polymer networks * designed precursor * crosslinking Subject RIV: CD - Macromolecular Chemistry

78 FR 33799 - National Poultry Improvement Plan; General Conference Committee Meeting

Science.gov (United States)

2013-06-05

... Washington, DC, this 3rd day of June 2013. Kevin Shea, Acting Administrator, Animal and Plant Health... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2013-0032] National Poultry Improvement Plan; General Conference Committee Meeting AGENCY: Animal and Plant Health...

Status of the French R/D program on the severe accident issue to develop Gen IV SFRs - 15373

International Nuclear Information System (INIS)

Serre, F.; Bertrand, F.; Journeau, C.; Suteau, C.; Verwaede, D.; Schmitt, D.; Farges, B.

2015-01-01

The ASTRID reactor (Advanced Sodium Technological Reactor for Industrial Demonstration) is a technological demonstrator designed by the CEA with its industrial partners, with very high levels of requirements. In the ASTRID project, the safety objectives are to prevent core melting, in particular by the development of an innovative core with complementary safety prevention devices, and to enhance the reactor resistance to severe accident by design. To mitigate the consequences of hypothetical core melting situations, specific dispositions or mitigation devices will be added to the core and to the reactor. It is also required to provide a robust safety demonstration (with high level of confidence). Therefore a new approach for severe accident issue has been defined: to the well-known 'lines of defense' method, a 'lines of mitigation' method is added. To meet these ASTRID, or future SFR, requirements, a large R/D program was launched in the Severe Accident domain, with a large number of partners. This paper will present the status of the CEA R/D related to the SFR Severe Accident issue, the collaboration framework (with industrial partners and R/D foreign organizations), and the future R/D plans to support the ASTRID project and possible developments for future Gen IV commercial SFR. (authors)

The Effects of State R&D Tax Credits in Stimulating Private R&D Expenditure: A Cross-State Empirical Analysis

Science.gov (United States)

Wu, Yonghong

2005-01-01

This is a cross-state empirical study which examines the effects of state research and development (R&D) tax credits on private R&D expenditure in the states. Other explanatory variables include federal R&D subsidies, public services in higher education and R&D-targeted programs as well as other control variables. The statistical result shows that…

BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice.

Science.gov (United States)

Zencak, Dusan; Crippa, Sylvain V; Tekaya, Meriem; Tanger, Ellen; Schorderet, Daniel E; Munier, Francis L; van Lohuizen, Maarten; Arsenijevic, Yvan

2006-01-01

Retinitis pigmentosa (RP) is a heterogeneous group of genetic disorders leading to blindness, which remain untreatable at present. Rd1 mice represent a recognized model of RP, and so far only GDNF treatment provided a slight delay in the retinal degeneration in these mice. Bmi1, a transcriptional repressor, has recently been shown to be essential for neural stem cell (NSC) renewal in the brain, with an increased appearance of glial cells in vivo in Bmi1 knockout (Bmi1-/-) mice. One of the roles of glial cells is to sustain neuronal function and survival. In the view of a role of the retinal Miller glia as a source of neural protection in the retina, the increased astrocytic population in the Bmi1-/- brain led us to investigate the effect of Bmi1 loss in Rd1 mice. We observed an increase of Müller glial cells in Rd1-Bmi1-/- retinas compared to Rd1. Moreover, Rd1-Bmi1-/- mice showed 7-8 rows of photoreceptors at 30 days of age (P30), while in Rd1 littermates there was a complete disruption of the outer nuclear layer (ONL). Preliminary ERG results showed a responsiveness of Rd1-Bmi1-/- mice in scotopic vision at P35. In conclusion, Bmi1 loss prevented, or rescued, photoreceptors from degeneration to an unanticipated extent in Rd1 mice. In this chapter, we will first provide a brief review of our work on the cortical NSCs and introduce the Bmi1 oncogene, thus offering a rational to our observations on the retina.

Complementarity in R&D cooperation strategies

NARCIS (Netherlands)

Belderbos, R.A.; Carree, M.A.; Lokshin, B.

2006-01-01

This paper assesses the performance effects of simultaneous engagement in R&D cooperation with different partners (competitors, clients, suppliers, and universities and research institutes). We test whether these different types of R&D cooperation are complements in improving productivity. The

Cooperative R&D and firm performance

NARCIS (Netherlands)

Belderbos, R.A.; Carree, M.A.; Lokshin, B.

2004-01-01

We analyse the impact of R&D cooperation on firm performance differentiating between four types of R&D partners (competitors, suppliers, customers, and universities and research institutes), and considering two performance measures: labour productivity and productivity in innovative (new to the

R&D Project Valuation Considering Changes of Economic Environment: A Case of a Pharmaceutical R&D Project

Directory of Open Access Journals (Sweden)

Jung Ho Park

2018-03-01

Full Text Available R&D project valuation is important for effective R&D portfolio management through decision making, related to the firm’s R&D productivity, sustainable management. In particular, scholars have emphasized the necessities of capturing option value in R&D and developed methods of real option valuation. However, despite suggesting various real option models, there are few studies on simultaneously employing mean-reverting stochastic process and Markov regime switching to describe the evolution of cash flow and to reflect time-varying parameters resulting from changes of economic environment. Therefore, we suggest a mean-reverting binomial lattice model under Markov regime switching and apply it to evaluate clinical development with project cases of the pharmaceutical industry. This study finds that decision making can be different according to the regime condition, thus the suggested model can capture risks caused by the uncertainty of the economic environment, represented by regime switching. Further, this study simulates the model according to rate parameter from 0.00 to 1.00 and risk-free interest rates for regimes 1 and 2 from ( r 1 = 4%, r 2 = 2% to ( r 1 = 7%, r 2 = 5%, and confirms the rigidity of the model. Therefore, in practice, the mean-reverting binomial lattice model under Markov regime switching proposed in this study for R&D project valuation contributes to assisting company R&D project managers make effective decision making considering current economic environment and future changes.

Design requirements for new nuclear reactor facilities in Canada (focus on important improvements from RD-337 version 1 of 2008)

International Nuclear Information System (INIS)

Shim, S.; Harwood, C.; Ohn, M-Y; Liu, Y.C.; Young, T.

2014-01-01

The Canadian Nuclear Safety Commission (CNSC) has established the regulatory framework that includes the documentation of the requirements and guidance for each of CNSC's 14 Safety and Control Areas, one important area being the design of nuclear power plants (NPPs). For the design area, the CNSC published RD-337 version 1 Design of New Nuclear Power Plants in 2008. As such regulatory documents are reviewed on a regular basis, this document was recently updated as RD-337 version 2, and its guidance document GD-337, Guidance for the Design of New Nuclear Power Plants was developed to provide guidance on how to meet the requirements. REGDOC-2.5.2 Design of Reactor Facilities: Nuclear Power Plants that combines RD-337 version 2 and GD-337 version 1 was presented to the Commission on March 27, 2014 after two rounds of consultation with stakeholders, and was subsequently published in May 28, 2014. Although REGDOC-2.5.2 maintains the structure and the contents nearly the same as RD-337 version 1, it introduces several important improvements to: Include GD-337 guidance for further clarity to applicants, licensees and vendors on how to meet the requirements. This guidance provides the review criteria considered in CNSC staff's review in a transparent way; Ensure alignment with international standards including recent IAEA SSR 2/1, Safety of Nuclear Power Plants: Design; Implement CNSC Fukushima Task Force Report findings that pertain to the design of reactor facilities for severe accidents; and, Make necessary improvements such as addition of requirements for cyber security. This paper describes the overall regulatory framework related to CNSC's design requirements and guidance for NPPs, and focus on the important improvements included in REGDOC-2.5.2 and their reasoning. (author)

Design requirements for new nuclear reactor facilities in Canada (focus on important improvements from RD-337 version 1 of 2008)

Energy Technology Data Exchange (ETDEWEB)

Shim, S.; Harwood, C.; Ohn, M-Y; Liu, Y.C.; Young, T. [Canadian Nuclear Safety Commission, Ottawa, ON (Canada)

2014-07-01

The Canadian Nuclear Safety Commission (CNSC) has established the regulatory framework that includes the documentation of the requirements and guidance for each of CNSC's 14 Safety and Control Areas, one important area being the design of nuclear power plants (NPPs). For the design area, the CNSC published RD-337 version 1 Design of New Nuclear Power Plants in 2008. As such regulatory documents are reviewed on a regular basis, this document was recently updated as RD-337 version 2, and its guidance document GD-337, Guidance for the Design of New Nuclear Power Plants was developed to provide guidance on how to meet the requirements. REGDOC-2.5.2 Design of Reactor Facilities: Nuclear Power Plants that combines RD-337 version 2 and GD-337 version 1 was presented to the Commission on March 27, 2014 after two rounds of consultation with stakeholders, and was subsequently published in May 28, 2014. Although REGDOC-2.5.2 maintains the structure and the contents nearly the same as RD-337 version 1, it introduces several important improvements to: Include GD-337 guidance for further clarity to applicants, licensees and vendors on how to meet the requirements. This guidance provides the review criteria considered in CNSC staff's review in a transparent way; Ensure alignment with international standards including recent IAEA SSR 2/1, Safety of Nuclear Power Plants: Design; Implement CNSC Fukushima Task Force Report findings that pertain to the design of reactor facilities for severe accidents; and, Make necessary improvements such as addition of requirements for cyber security. This paper describes the overall regulatory framework related to CNSC's design requirements and guidance for NPPs, and focus on the important improvements included in REGDOC-2.5.2 and their reasoning. (author)

Moving R&D to the Marketplace, A Guidebook for Technology Transfer Managers

Energy Technology Data Exchange (ETDEWEB)

Mock, John E.; Kenkeremath, Deepak C.; Janis, F. Timothy

1993-01-01

This Guidebook serves as an introduction as well as a refresher for technology transfer managers. It focuses on the question: What can the Technology Transfer manager do when confronted by complex situations and events? The main functional issues addressed here concern the conduct of technology transfer in Technology Utilization programs. These R&D programs whose primary mission is to develop technologies that will be used outside of the Federal sector. Renewable energy, health care, and agricultural advances are technologies of this type. The contents of this Guidebook will be of value to managers in a variety of Federal, State, university and industry technology development and transfer programs. The general area of transferring service innovations is not covered here. The Guidebook is primarily about the development and care of hardware. This Guidebook makes no attempt to judge the value of specific technologies in meeting societal needs. Rather, it addresses the improvement of the technology transfer process itself. It does, however, include reminders that ascertainment of the social value of specific technologies is one of the important yet difficult tasks of R&D and technology transfer programs. [DJE-2005

Strategic Sourcing of R&D: The Determinants of Success

Science.gov (United States)

Brook, Jacques W.; Plugge, Albert

The outsourcing of the R&D function is an emerging practice of corporate firms. In their attempt to reduce the increasing cost of research and technology development, firms are strategically outsourcing the R&D function or repositioning their internal R&D organisation. By doing so, they are able to benefit from other technology sources around the world. So far, there is only limited research on how firms develop their R&D sourcing strategies and how these strategies are implemented. This study aims to identify which determinants contribute to the success of R&D sourcing strategies. The results of our empirical research indicate that a clear vision of how to manage innovation strategically on a corporate level is a determinant of an effective R&D strategy. Moreover, our findings revealed that the R&D sourcing strategy influences a firm's sourcing capabilities. These sourcing capabilities need to be developed to manage the demand as well as the supply of R&D services. The alignment between the demand capabilities and the supply capabilities contributes to the success of R&D sourcing.

40 CFR 63.1563 - When do I have to comply with this subpart?

Science.gov (United States)

2010-07-01

... National Emission Standards for Hazardous Air Pollutants for Petroleum Refineries: Catalytic Cracking Units, Catalytic Reforming Units, and Sulfur Recovery Units What This Subpart Covers § 63.1563 When do I have to... for an existing catalytic cracking unit allowing additional time to meet the emission limitations and...

Decision Making in R&D Outsourcing

DEFF Research Database (Denmark)

Bals, Lydia; Kneis, Kyra; Lemke, Christine

2011-01-01

In an increasingly competitive environment, the pharmaceutical industry faces increasing R&D costs and longer development times, which increase a product’s time to market. Therefore, the issue of costs and outsourcing of R&D is increasing in importance, but systematic approaches for understanding...

40 CFR 63.1184 - What do I need to know about the design specifications, installation, and operation of a bag leak...

Science.gov (United States)

2010-07-01

... design specifications, installation, and operation of a bag leak detection system? 63.1184 Section 63... bag leak detection system? A bag leak detection system must meet the following requirements: (a) The bag leak detection system must be certified by the manufacturer to be capable of detecting PM...

R&D proposal the prism plastic calorimeter:PPC

CERN Document Server

Dobrzynski, Ludwik; Marchand, P; Nédélec, P; Salin, P; CERN. Geneva. Detector Research and Development Committee

1990-01-01

This proposal supports two goals: First Goal_Demonstrate that current, widely used plastic technologies allow to design Prism Plastic Calorimeter (PPC) towers with a new "liquid crystal" type plastic called Vectra. It will be shown that this technique meets the requirements for a LHC calorimeter with warm liquids: safety, hermeticity, hadronic compensation, resolution and time response. Second Goal_ Describe how one can design a warm liquid calorimeter integrated into a LHC detector,and list the advantages of the PPC: low price, minimum of mechanical structures, minimum amount of dead space, easiness of mechanical assembly, accessibility to the electronics, possibility to recirculate the liquid. The absorber and the electronics being outside the liquid and easily accessible, one has maximum flexibility to define them. The R&D program we define here aims at showing the feasibility of these new ideas by building nine towers of twenty gaps and exposing them to electron and hadron beams.

Export performance and investment in R&D

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

Do R&D Investments Affect Export Performance?

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

Performance measurement in industrial R&D

NARCIS (Netherlands)

Kerssens-van Drongelen, I.C.; Nixon, Bill; Pearson, Alan

2000-01-01

Currently, the need for R&D performance measurements that are both practically useful and theoretically sound seems to be generally acknowledged; indeed, the rising cost of R&D, greater emphasis on value management and a trend towards decentralization are escalating the need for ways of evaluating

ATLAS Cloud Computing R&D project

CERN Document Server

Panitkin, S; The ATLAS collaboration; Caballero Bejar, J; Benjamin, D; DiGirolamo, A; Gable, I; Hendrix, V; Hover, J; Kucharczuk, K; Medrano LLamas, R; Ohman, H; Paterson, M; Sobie, R; Taylor, R; Walker, R; Zaytsev, A

2013-01-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained...

Some experiences of public meetings/involvement in Sweden

International Nuclear Information System (INIS)

Stroemberg, Bo

2008-01-01

Bo Stroemberg from SKI presented recent Swedish experiences of public meetings organised in connection with site investigations and the regular review of RD and D programmes. He introduced examples of stakeholder concerns that have been expressed during RD and D programme reviews. Academic institutions have identified needs for additional research. Environmental groups have raised concerns about potential disruptive events and degradation mechanisms. They have called attention to deficiencies related to decision-making processes, and recommended alternative approaches for site and method selection. Municipalities and local authorities have been critical about the insufficient degree of transparency, while other authorities have focused on legal responsibility, transport safety, and security issues, among others. Next, Mr Stroemberg highlighted examples of technical comments concerning long-term safety. Some of these referred to catastrophic impacts of earthquakes, especially the formation of new fractures, which could invalidate the KBS-3 concept. Others called attention to scenarios of deliberate human intrusion, if for example the repository was excavated as an archaeological site. Some comments concerned the issue of retrievability, the greatest advantage of the KBS-3 method, but also its most important shortcoming, since it would necessitate monitoring and surveillance indefinitely. Some suggested that an inland site with regional recharge conditions should be used, while others proposed the use of deep boreholes, i.e., the location of the repository in deep stagnant conditions. Mr Stroemberg concluded that questions and comments put during public meetings represent useful information to the experts for the identification of issues to be addressed by RD and D

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 77, Revision 1 (FGE.77Rev1): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting)

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

for isoquinoline [FL-no: 14.001], pyrrole [FL-no: 14.041] and 2-acetylpyrrole [FL-no: 14.047]. The toxicity data on 2-acetylpyrrole should also cover 2-propionylpyrrole [FL-no: 14.068]. Further, additional genotoxicity data on 6-methylquinoline [FL-no: 14.042] have become available. The Panel concluded that for 6......-methylquinoline [FL-no: 14.042], the new genotoxicity data did not clear the concern with respect to genotoxicity in vitro and accordingly the substance is not evaluated through the Procedure. For 18 substances [FL-no: 14.001, 14.004, 14.007, 14.030, 14.038, 14.039, 14.041, 14.047, 14.058, 14.059, 14.060, 14...

53rd Annual Meeting

Indian Academy of Sciences (India)

1987-07-01

Jul 1, 1987 ... Wickramasinghe, gave a Significantly better account of ... provide a possible environment for amplification of this material ..... throughout his service and to earn stipulated rewards ..... birds and applied for a year's training in.

77 FR 47864 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

Science.gov (United States)

2012-08-10

...), Interior. ACTION: Notice of meeting. SUMMARY: OESC will meet at the Anchorage Marriott Downtown Hotel in..., from 8 a.m. to 1 p.m. ADDRESSES: Anchorage Marriott Downtown Hotel, 820 West 7th Avenue, Anchorage... the Office of Management and Budget's Circular No. A-63, Revised. Dated: August 1, 2012. James A...

10 CFR 1045.9 - RD classification performance evaluation.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false RD classification performance evaluation. 1045.9 Section... classification performance evaluation. (a) Heads of agencies shall ensure that RD management officials and those... RD or FRD documents shall have their personnel performance evaluated with respect to classification...

R&D as an option on market introduction

NARCIS (Netherlands)

Lint, L.J.O.; Pennings, H.P.G.

1998-01-01

Discounted cash flow methods for making R&D investment decisions cannot properly capture the option value in R&D. Since market and technology uncertainties change expectations about the viability of many new products, the value of projects is frequently adjusted during the R&D stages. Capturing the

Chinese Foreign Direct Investment in R&D in Europe

DEFF Research Database (Denmark)

Di Minin, Alberto; Zhang, Jieyin; Gammeltoft, Peter

2012-01-01

’ investment in R&D in Europe, focusing on three different aspects: technology exploration vs. technology exploitation as investment motive; locational strategies for R&D investments; and the dynamics of motives of overseas R&D units. The analysis proceeds to draw out differences between the R...... rather than technological innovation, as the extant literature tends to assume. Chinese R&D units appear to evolve often from a strategy of pure technology exploration, over fusion of foreign technologies with R&D activities back home, into one of technology exploitation in foreign locations.......&D internationalization process of multinationals from developed economies and those from emerging economies. Evidence of Chinese R&D internationalization is provided through analyses of five cases of international R&D units set up by Chinese companies in Europe: ZTE Corporation, JAC Motors, Chang’an Motors, Hisense...

Does R&D pay?

Science.gov (United States)

Cavalla, David; Minhas, Raman

2010-03-01

Pharmaceutical R&D is notoriously risky, lengthy and costly; moreover, it does not always produce products of blockbuster status. The conventional route of fully discovering, developing and marketing a new chemical entity is followed by the large pharmaceutical companies, whereas other organizations in the pharmaceutical sector--such as generic or specialty companies and biotechnology companies--only operate over portions of the full R&D process. Here, we compare the ten-year financial performance of these three subsectors through their price/earnings ratios and their return on capital metrics to understand which of these strategic alternatives offered the best return to investors. 2009 Elsevier Ltd. All rights reserved.

CAST Status Report to the SPSC for the 123rd Meeting

CERN Document Server

Desch, K

2016-01-01

After the successful 2015 data taking with Micromegas detectors, targeting solar axion search, and with an InGrid detector, targeting solar chameleon search, CAST has started on its new 2016-2018 program which has been presented to SPSC at the 119th meeting in October 2015. This program extends the physics goals of CAST towards the search for solar chameleons using a force sensor (KWISP) and towards the search for relic axions using a microwave cavity inserted into the CAST magnet (CAST-CAPP). The search for solar chameleons and other axion-like particles was continued with a significantly upgraded InGrid detector. The new experiments make use different elements of the unique CAST infrastructure (KWISP: Abrixas XRT and sun pointing capability of CAST, CAST-CAPP: high magnetic dipole field), while the InGrid detector exploits all of CAST´s features (Abrixas XRT, high magnetic dipole field, sun pointing). All three experiments within CAST have made significant progress in exploring these new approaches in 2016...

24. annual meeting of the International working group on fast reactors, Tsuruga, Japan, 15-18 April 1991

International Nuclear Information System (INIS)

1991-05-01

The agenda of the meeting included approval of the minutes of the 23rd meeting of the IWGFR, report of the Scientific Secretary regarding the activities of the Working Group, short presentation on national situation in nuclear energy and in the fast reactor field in particular, consideration of conferences on fast breeder reactors, consideration of arrangements for specialists' meetings in 1991, selection of topics for specialists' meetings to be held in 1992, consideration of joint research activities, informal discussion on ''The Economics of Fast Reactors''

MNE R&D Subsidiary Mandates Evolution in Emerging Economies

DEFF Research Database (Denmark)

Schulzmann, David; Slepniov, Dmitrij

2017-01-01

The aim of this paper is to present the results of a systematic literature review (SLR) on the subject of Research and Development (R&D) subsidiary mandate evolution in emerging economies and to illustrate what triggers R&D mandate upgrade. The subject of R&D mandates is of crucial importance to ...... on subsidiary evolution in general and particularly in emerging markets. From a practical perspective, a better-integrated framework can provide guidance to businesses in emerging economies on how to start and successfully upgrade their R&D activities.......The aim of this paper is to present the results of a systematic literature review (SLR) on the subject of Research and Development (R&D) subsidiary mandate evolution in emerging economies and to illustrate what triggers R&D mandate upgrade. The subject of R&D mandates is of crucial importance...... to many multinational enterprises (MNEs) striving to utilize the potential of their foreign operations towards higher-value-added activities. While developed economies have long been a destination for R&D activities, emerging economies are increasingly recognized for their innovation potential. Previous...

Why do manufacturing industries invest in energy R&D?

OpenAIRE

Costa, M. Teresa (Maria Teresa), 1951-; Garcia-Quevedo, Jose

2017-01-01

Energy R&D can have major social and economic impacts and is a critical factor in addressing the challenges presented by climate change mitigation policies. As well as the energy utilities themselves, firms in other sectors also invest in energy R&D; however, while various studies have examined the determinants of R&D in the former, there are no analyses of energy R&D drivers in other industries. This paper seeks to fill this gap by examining the determinants of investment in energy R&D in no...

Retrospective insights from real options in R&D

NARCIS (Netherlands)

Lint, L.J.O.

2000-01-01

Absent empirical validation of real option pricing in R&D, we discuss the evolution of three cases in R&D option valuation. The first case concerns an option on conversion of an existing production process. The other two cases concern R&D to develop new product technology in the consumer electronics

40 CFR 63.7182 - What parts of my facility does this subpart cover?

Science.gov (United States)

2010-07-01

...; associated wet and dry work benches; associated recovery devices; feed, intermediate, and product storage... construction of the affected source after May 8, 2002, and you meet the applicability criteria in § 63.7181 at the time you commence construction. (d) Your affected source is a reconstructed affected source if you...

Do specialists exit the firm outsourcing its R&D?

DEFF Research Database (Denmark)

Wang, Wenjing

Do specialists exit the firm increasingly outsourcing its research and development (R&D) work? Although this question is critical in understanding how R&D outsourcing links to innovation performance, the answer is not yet clear. This paper proposes that the optimal level of firm's internal...... employment of R&D specialists decreases with the deepening of R&D outsourcing but increases with the broadening of R&D outsourcing. These relations can be inferred from previous empirical studies as well as our theoretical analysis, and are supported by the empirical evidence from estimations of correlated...

R&D Personnel Career Routes: An Exploratory Study

Directory of Open Access Journals (Sweden)

Barbara Bigliardi

2009-05-01

Full Text Available This study, aiming at investigate the alternative modes of career development for personnel belonging to R&D staff, addresses the extent to which career anchors are applicable to R&D staff and to examine the relationship among career anchors, gender and age, with the final purpose to add elements of discussion to the long-lasting debate about this matter. With this purpose in mind, we developed a questionnaire survey among 309 R&D personnel employed at firms belonging to the food machinery industry in a Northern Italy district. The results obtained from the statistical analysis indicate that the R&D personnel’s career orientations is a predictor of their career routes preferences, confirming three possible career routes in R&D labs that were highlighted in previous studies.

Proceedings of the third Marcel Grossmann meeting on general relativity

International Nuclear Information System (INIS)

Hu Ning

1983-01-01

This book contains 64 session papers presented at the 3rd Marcel Grossmann Meeting on General Relativity. The papers are divided into 10 sections including: classical problem in gravitation; alternative approaches to gravitational theory; supergravity; quantum gravity and quantum field theory in curved space; cosmology; early universe; physics of compact bodies; gravitational wave experiments; gravitational experiments; miscellaneous. (Auth.)

The Israel Physical Society 1997 Annual Meeting. Program and abstracts

International Nuclear Information System (INIS)

1997-01-01

The book of program and abstracts of the 43rd meeting of the Israel physical society presents abstracts of presentations in various field of physics. Follow is the list of these fields. Astrophysics, condensed matter, laser and quantum optics, nuclear physics, particle and fields, physics in biology, physics in industry, plasma and space physics, statistical physics and nonlinear dynamics

Development of an IgG4-RD Responder Index

Directory of Open Access Journals (Sweden)

Mollie N. Carruthers

2012-01-01

Full Text Available IgG4-related disease (IgG4-RD is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are required to clarify the natural history, long-term prognosis, and treatment approaches in this recently recognized condition. Patients with IgG4-RD have different organ manifestations and are followed by multiple specialties. Divergent approaches to the assessment of patients can complicate the interpretation of studies, emphasizing the critical need for validated outcome measures, particularly assessments of disease activity and response to treatment. We developed a prototype IgG4-RD Responder Index (IgG4-RD RI based on the approach used in the development of the Birmingham Vasculitis Activity Score for Wegener’s granulomatosis (BVAS/WG. The IgG4-RD RI was refined by members of the International IgG4-RD Symposium Organizing Committee in a paper case exercise. The revised instrument was applied retrospectively to fifteen IgG4-RD patients at our institution. Those scores were compared to physician’s global assessment scale for the same visits. This paper describes the philosophy and goals of the IgG4-RD RI, the steps in the development of this instrument to date, and future plans for validation of this instrument as an outcome measure.

Creating a global observatory for health R&D.

Science.gov (United States)

Terry, Robert F; Salm, José F; Nannei, Claudia; Dye, Christopher

2014-09-12

A global map of health R&D activity would improve the coordination of research and help to match limited resources with public health priorities, such as combating antimicrobial resistance. The challenges of R&D mapping are large because there are few standards for research classification and governance and limited capacity to report on R&D data, especially in low-income countries. Nevertheless, based on developments in semantic classification, and with better reporting of funded research though the Internet, it is now becoming feasible to create a global observatory for health R&D. Copyright © 2014, American Association for the Advancement of Science.

Proceedings of the fuels technology contractors review meeting

Energy Technology Data Exchange (ETDEWEB)

Malone, R.D. [ed.

1993-11-01

The Fuels Technology Contractors Review Meeting was held November 16-18, 1993, at the Morgantown Energy Technology Center (METC) in Morgantown, West Virginia. This meeting was sponsored and hosted by METC, the Office of Fossil Energy, U.S. Department of Energy (DOE). METC periodically provides an opportunity to bring together all of the R&D participants in a DOE-sponsored contractors review meeting to present key results of their research and to provide technology transfer to the active research community and to the interested public. This meeting was previously called the Natural Gas Technology Contractors Review Meeting. This year it was expanded to include DOE-sponsored research on oil shale and tar sands and so was retitled the Fuels Technology Contractors Review Meeting. Current research activities include efforts in both natural gas and liquid fuels. The natural gas portion of the meeting included discussions of results summarizing work being conducted in fracture systems, both natural and induced; drilling, completion, and stimulation research; resource characterization; delivery and storage; gas to liquids research; and environmental issues. The meeting also included project and technology summaries on research in oil shale, tar sands, and mild coal gasification, and summaries of work in natural-gas fuel cells and natural-gas turbines. The format included oral and poster session presentations. Individual papers have been processed separately for inclusion in the Energy Science and Technology database.

Mergers and Acquisitions (M&AS by R&D Intensive Firms

Directory of Open Access Journals (Sweden)

Shantanu Dutta

2009-12-01

Full Text Available In this study, we evaluate the impact of R&D intensity on acquiring firms’ abnormal returns by examining 925 Canadian completed deals between 1993 and 2002 that have information on R&D expenditures. While examining the returns to acquiring firm shareholders in the R&D intensive firms we evaluate two competing hypotheses: ‘growth potential hypothesis’ and ‘integration failure hypothesis’. According to the ‘growth potential hypothesis’, in light of the growth potential of the targets acquired by R&D intensive firms, investors are likely to react positively. ‘Integration failure hypothesis’ focuses on integration difficulties of a target by an R&D intensive firms and suggests that investor might be skeptical of such acquisitions and react negatively. Our results show that R&D intensity (i.e. R&D expenditure by sales has a positive and significant effect on cumulative abnormal returns of the acquiring firms around the announcement dates. This implies that market generally favors the M&A deals by R&D intensive firms. An analysis of the differentiating characteristics reveal that R&D firms have a significantly higher growth potential and undertake more stock financed deals compared to the non R&D firms. Further, our results show that there is no significant change in long-term operating performance subsequent to the M&A deals for both R&D firms and non R&D firms. In general, our results show support for ‘growth potential hypothesis’.

N9-Substituted N(6)-[(3-methylbut-2-en-1-yl)amino]purine derivatives and their biological activity in selected cytokinin bioassays

Czech Academy of Sciences Publication Activity Database

Mik, V.; Szüčová, Lucie; Spíchal, Lukáš; Plíhal, O.; Nisler, Jaroslav; Zahajská, L.; Doležal, Karel; Strnad, Miroslav

2011-01-01

Roč. 19, č. 23 (2011), s. 7244-7251 ISSN 0968-0896 R&D Projects: GA MŠk ED0007/01/01; GA ČR GA522/09/1576 Keywords : N6-[(3-Methylbut-2-en-1-yl)amino]purine * Isopentenyladenine derivatives * N9-Substituted derivatives * Cytokinins * Cytokinin receptors Subject RIV: EF - Botanics Impact factor: 2.921, year: 2011

R&D productivity rides again?

Science.gov (United States)

Lendrem, Dennis; Senn, Stephen J; Lendrem, B Clare; Isaacs, John D

2015-01-01

A recent analysis of R&D productivity suggests that there are grounds for 'cautious optimism' that the industry 'turned the corner' in 2008 and is 'on the comeback trail'. We believe that this analysis is flawed and most probably wrong. We present an alternative analysis of these same data to suggest that the industry is not yet 'out of the woods' and suggest that many of the systemic issues affecting pharmaceutical R&D productivity are still being resolved. Copyright © 2014 John Wiley & Sons, Ltd.

Recent Korean R&D in Satellite Communications

Science.gov (United States)

Lee, Ho-Jin; Kim, Jae Moung; Lee, Byung-Seub; Lee, Han; Ryoo, Jang-Soo

The R&D in satellite communications in Korea has been driven mainly by KCC (Korea Communications Commission) but in a small scale compared to Korea space development program organized by MEST (Ministry of Education, Science and Technology). Public and civilian satcom sector R&D has been led mainly by ETRI with small/medium companies contrary to rare investment in private sector while military sector R&D has been orchestrated by ADD with defense industry. By the COMS (Communication, Ocean and Meteorological Satellite) experimental Ka-band payload, Korea pursues a space qualification of own technology for national infrastructure evolution as well as industrialization of space R&D results. Once COMS launched and space qualified in 2009, subsequent application experiments and new technology R&D like UHDTV will entail service and industry promotion. The payload technology is expected for the next Korean commercial satellites or for new OBP satellites. The COMS ground control system and GNSS ground station technologies are under development for COMS operation and enhanced GNSS services along with advent of Galileo respectively. Satellite broadband mobile VSAT based on DVB-S2/RCS (+M) and low profile tracking antennas have been developed for trains, ships, and planes. While APSI is developing GMR-1 based Thuraya handset functions, ETRI is designing IMT-Advanced satellite radio interface for satellite and terrestrial dual-mode handheld communication system like Japanese STICS, with universities' satellite OFDM researches. A 21GHz Ka-band higher-availability scalable HD broadcasting technology and SkyLife's hybrid satellite IPTV technology are being developed. In near term Korea will extend R&D programs to upgrade the space communication infrastructure for universal access to digital opportunity and safer daily life from disaster, and to promote space green IT industrialization, national security, and space resources sovereign. Japanese stakeholders are invited to establish

The antecedents of new R&D collaborations with different partner types: On the dynamics of past R&D collaboration and innovative performance

NARCIS (Netherlands)

Belderbos, René; Gilsing, Victor; Lokshin, Boris; Carree, Martin; Sastre, Juan Fernández

2017-01-01

We examine firms' propensity to adapt their R&D collaboration portfolio by establishing new types of R&D collaboration with different kinds of partners (suppliers, customers, competitors and universities & public research institutions). We argue that existing R&D collaboration with one of the two

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

2014-01-01

The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...... multinationals leads to a reduction in R&D activity in the country. We use unique and rich firm level data for the Swedish manufacturing sector and micro-econometric estimation strategies in order to control for the potential endogeneity of the acquisition decision. Overall, our results give no support...... to the fears that foreign acquisition of domestic firms lead to a relocation of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic MNEs and non-MNEs....

Multinational Exploration of Acquired R&D Activities

DEFF Research Database (Denmark)

Gammelgaard, Jens

2004-01-01

R&D. This paper establishes the connection between amultinational corporation that follows a capability-motivated acquisition strategy and theR&D role new subsidiaries should play in order for the acquired resources to be utilizedcorporation-wide. Statistical findings reveal the need to follow......This paper presents the results of a survey of 54 Danish multinational corporations that haveacquired activities abroad. The role of the acquired R&D units was the focus of the survey,particularly with respect to the schism between basic and applied R&D, and the schismbetween autonomous and network...

For information MANAGEMENT BOARD MEETING OF 29 MARCH 2001

CERN Multimedia

2001-01-01

Outcome of the March Meetings of the Scientific Policy Committee, Finance Committee and Committee of Council and the Extraordinary Session of the Council Chairing the meeting in the Director-General's absence, R. Cashmore, Director for Collider Programmes, briefly reviewed the outcome of the meetings that had taken place during the week beginning 12 March. Among the salient points, the Scientific Policy Committee and the Committee of Council had held a preliminary discussion on LHC computing activities and resources, which would be followed up by the presentation of a formal proposal to the Council and its three committees in June. Similarly, the Scientific Policy Committee had discussed the question of accelerator and detector R&D on the basis of an oral report from the Director-General, and a written report taking account of the comments made was to be drawn up for the June meetings. In addition, the Committee of Council had heard a first report by the Working Group on the Enlargement of CERN's Memb...

Solid-State Lighting R&D Plan - 2015

Energy Technology Data Exchange (ETDEWEB)

Bardsley, Norman [Bardsley Consulting, Danville, CA (United States); Bland, Stephen [SB Consulting, Nashville, TN (United States); Hansen, Monica [LED Lighting Advisors, Santa Barbara, CA (United States); Pattison, Lisa [Solid State Lighting Services, Inc., Santa Barbara, CA (United States); Pattison, Morgan [Solid State Lighting Services, Inc., Santa Barbara, CA (United States); Stober, Kelsey [Navigant Consulting, Inc., Chicago, IL (United States); Yamada, Mary [Navigant Consulting, Inc., Chicago, IL (United States)

2015-05-28

Provides analysis and direction for ongoing R&D activities to advance SSL technology and increase energy savings, reviewing SSL technology status and trends for both LEDs and OLEDs and offering an overview of the current DOE SSL R&D project portfolio.

RD-MolPack technology for the constitutive production of self-inactivating lentiviral vectors pseudotyped with the nontoxic RD114-TR envelope.

Science.gov (United States)

Marin, Virna; Stornaiuolo, Anna; Piovan, Claudia; Corna, Stefano; Bossi, Sergio; Pema, Monika; Giuliani, Erica; Scavullo, Cinzia; Zucchelli, Eleonora; Bordignon, Claudio; Rizzardi, Gian Paolo; Bovolenta, Chiara

2016-01-01

To date, gene therapy with transiently derived lentivectors has been very successful to cure rare infant genetic diseases. However, transient manufacturing is unfeasible to treat adult malignancies because large vector lots are required. By contrast, stable manufacturing is the best option for high-incidence diseases since it reduces the production cost, which is the major current limitation to scale up the transient methods. We have previously developed the proprietary RD2-MolPack technology for the stable production of second-generation lentivectors, based on the RD114-TR envelope. Of note, opposite to vesicular stomatitis virus glycoprotein (VSV-G) envelope, RD114-TR does not need inducible expression thanks to lack of toxicity. Here, we present the construction of RD2- and RD3-MolPack cells for the production of self-inactivating lentivectors expressing green fluorescent protein (GFP) as a proof-of-concept of the feasibility and safety of this technology before its later therapeutic exploitation. We report that human T lymphocytes transduced with self-inactivating lentivectors derived from RD3-MolPack cells or with self-inactivating VSV-G pseudotyped lentivectors derived from transient transfection show identical T-cell memory differentiation phenotype and comparable transduction efficiency in all T-cell subsets. RD-MolPack technology represents, therefore, a straightforward tool to simplify and standardize lentivector manufacturing to engineer T-cells for frontline immunotherapy applications.

Institutionalizing end-user demand steering in agricultural R&D: Farmer levy funding of R&D in The Netherlands

NARCIS (Netherlands)

Klerkx, L.W.A.; Leeuwis, C.

2008-01-01

The purpose of this paper is to critically examine the institutionalization of demand-driven modes of working in the R&D planning process and reveal possible weaknesses, through an analysis of a system of collective R&D funding by farmers. The findings indicate that, although end-users have

An R&D Management Framework for Eco-Technology

Directory of Open Access Journals (Sweden)

Kenji Sano

2011-08-01

Full Text Available Although research and development (R&D affects new value-added creation, including that related to environmental aspects, there is little literature dealing with the integration of R&D management and eco-value. Here, eco-value of technology is defined as the advantage of environmental competitiveness in the market. This paper proposes a framework of R&D management of eco-technology (RDMOET, consisting of: (1 future research for sustainability; (2 making an original eco-theme portfolio and roadmap; (3 gap analysis and implementation of new eco-themes; and (4 eco-value evaluation. (1 and (4 are new processes compared with conventional R&D management. Through practice at the Corporate R&D Center of Toshiba Corporation, the usefulness of the proposed framework is verified from the viewpoint of not only technological eco-innovation, but also that of organizational learning for environmental sustainability.

WHO's role in the global health system: what can be learned from global R&D debates?

Science.gov (United States)

Moon, Suerie

2014-02-01

Recent global debates on the research and development (R&D) of health technologies, such as drugs, diagnostics and vaccines, can be seen as a microcosm of discussions on the role of the World Health Organization (WHO) in the global health system more broadly. The global R&D system has come under heightened scrutiny with the publication of a 2012 report by the WHO Consultative Expert Working Group on Research and Development (CEWG), which made a number of recommendations to more equitably meet global health needs. The CEWG report followed a decade-long process of debate at the WHO on the weaknesses of the global R&D system, which include problems of affordability, limited research where market returns are small or uncertain (such as the 'neglected diseases' that predominantly affect the world's poorest), inefficient overlap of research efforts, and overuse of medicines such as antibiotics. The CEWG report called on WHO Member States to develop a global framework to improve monitoring, coordination and financing of R&D efforts through the establishment of a Global Health R&D Observatory and the negotiation of a binding treaty on R&D. While the treaty option has been put on the back-burner for several years, Member States nevertheless agreed at the 2013 World Health Assembly (WHA) on concrete steps towards a global framework. Progress at the 2013 WHA reaffirmed the central role of WHO as a convener, and the WHA's decision to create the Observatory within the WHO Secretariat underscored the organization's role as a source of strategic knowledge in the global health system. However, despite WHO's constitutional mandate as the 'directing and coordinating authority on international health work', in reality it faces major challenges in coordinating autonomous R&D actors such as states, firms and foundations in the global system. Strengthening its ability to do so requires, at a minimum, reforming its financing arrangements to provide it with a greater degree of

Outsourcing R&D Modules of a New Developing Technology

DEFF Research Database (Denmark)

Pedersen, Jørgen Lindgaard; Perunovic, Zoran

2004-01-01

The paper explores some of the dimensions of the R&D processes: modularity, uncertainty and outsourcing. Ways to divide R&D effort into modules and to argue, either in direction of its modularity, or interdependency, are presented. Further on, uncertainties are segmented into the majors and minors......, and reasons to outsource R&D modules, in the light of these uncertainties, have been investigated. The R&D process has been observed from insulin technologies development over time....

Proceedings of the specialist meeting on positron annihilation study for science and engineering 2011

International Nuclear Information System (INIS)

Shirai, Yasuharu; Yoshiie, Toshimasa

2012-01-01

The utilization of positron beams in the field of materials science and engineering has increased remarkably in these years. It is meaningful for researches working in this field to gather together to promote and exchange views and information between them. For this purpose, the Specialist Research Meeting on Positron Beam Techniques for Science and Engineering was held on December 2nd and 3rd, 2011 at the Research Reactor Institute, Kyoto University. 66 participants jointed the Meeting and 28 papers were presented. This volume contains the summary and selected transparencies presented in the meeting. (J.P.N.)

Characterizing chronic and acute health risks of residues of veterinary drugs in food: latest methodological developments by the joint FAO/WHO expert committee on food additives.

Science.gov (United States)

Boobis, Alan; Cerniglia, Carl; Chicoine, Alan; Fattori, Vittorio; Lipp, Markus; Reuss, Rainer; Verger, Philippe; Tritscher, Angelika

2017-11-01

The risk assessment of residues of veterinary drugs in food is a field that continues to evolve. The toxicological end-points to be considered are becoming more nuanced and in light of growing concern about the development of antimicrobial resistance, detailed analysis of the antimicrobial activity of the residues of veterinary drugs in food is increasingly incorporated in the assessment. In recent years, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) has refined its approaches to provide a more comprehensive and fit-for-purpose risk assessment. This publication describes in detail the consideration of acute and chronic effects, the estimation of acute and chronic dietary exposure, current approaches for including microbiological endpoints in the risk assessment, and JECFA's considerations for the potential effects of food processing on residues from veterinary drugs. JECFA now applies these approaches in the development of health-based guidance values (i.e. safe exposure levels) for residues of veterinary drugs. JECFA, thus, comprehensively addresses acute and chronic risks by using corresponding estimates for acute and chronic exposure and suitable correction for the limited bioavailability of bound residues by the Gallo-Torres model. On a case-by-case basis, JECFA also considers degradation products that occur from normal food processing of food containing veterinary drug residues. These approaches will continue to be refined to ensure the most scientifically sound basis for the establishment of health-based guidance values for veterinary drug residues.

Changing R&D models in research-based pharmaceutical companies.

Science.gov (United States)

Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

2016-04-27

New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major research-based pharmaceutical companies and analyzed the key challenges and success factors of a sustainable R&D output. We calculated that the R&D efficiencies of major research-based pharmaceutical companies were in the range of USD 3.2-32.3 billion (2006-2014). As these numbers challenge the model of an innovation-driven pharmaceutical industry, we analyzed the concepts that companies are following to increase their R&D efficiencies: (A) Activities to reduce portfolio and project risk, (B) activities to reduce R&D costs, and (C) activities to increase the innovation potential. While category A comprises measures such as portfolio management and licensing, measures grouped in category B are outsourcing and risk-sharing in late-stage development. Companies made diverse steps to increase their innovation potential and open innovation, exemplified by open source, innovation centers, or crowdsourcing, plays a key role in doing so. In conclusion, research-based pharmaceutical companies need to be aware of the key factors, which impact the rate of innovation, R&D cost and probability of success. Depending on their company strategy and their R&D set-up they can opt for one of the following open innovators: knowledge creator, knowledge integrator or knowledge leverager.

R&D Spillovers with Endogenous Absorptive Capacity: Lessons for Developing Countries

Directory of Open Access Journals (Sweden)

Chankwon Bae

2016-06-01

Full Text Available This paper analyzes the role of absorptive capacity in R&D spillovers through strategic R&D investments in a game-theoretic framework. In the model, a firm's effective R&D is composed of idiosyncratic R&D, which produces its own innovations, and identical R&D, which improves absorptive capacity. The model shows that in the presence of absorptive capacity firms have a tendency to underinvest (overinvest in idiosyncratic (identical R&D relative to the social optimum. As the spillover becomes larger, firms decrease their own R&D while they become more inclined towards strategic exploitation of rivals' efforts. Since the former effect overpowers the latter, the total amount of R&D decreases as the spillover increases. This is socially undesirable, providing a potential justification for a governmental subsidy for idiosyncratic R&D and a tax on identical R&D. The findings may have important implications for newly industrialized or emerging countries that consider a redirection of national R&D policy and intellectual property rights (IPR regime.

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

endogeneity of the acquisition dummy.  Overall, our results give no support to the fears that foreign acquisition of domestic firms lead to a brain drain of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic......The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...

Stategic reorientation of industrial R&D towards commercial objectives.

NARCIS (Netherlands)

Brook, Jacques W.; de Bruijn, E.J.; McDonough III, Edward F.; Kaynak, E.; Harcar, T.D.

2007-01-01

In an effort to leverage R&D knowledge asset and to create more value from industrial R&D in today’s increasing liberalized and globalising business environments, some corporations adopt a strategic reorientation of their industrial R&D organisation towards commercial objectives. This study suggests

Openness, Growth and R&D Spillovers : Uncovering the Missing Link?

NARCIS (Netherlands)

Lejour, (Arjan Marcel); Nahuis, Richard

2000-01-01

We examine the trade-related diffusion of R&D in three steps. First, using OECD and UNESCO data we provide an overview of global R&D expenditures. Second, we estimate the relation between sectoral R&D expenditures and growth. Finally, these R&D linkages are incorporated in WorldScan: a dynamic

Changing R&D models in research-based pharmaceutical companies

OpenAIRE

Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

2016-01-01

New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major re...

R&D 100 Awards Demonstrate Clean Energy Legacy - Continuum Magazine |

Science.gov (United States)

Intel to develop an innovative warm-water, liquid-cooled supercomputer that later won an R&D 100 Award. Photo by Dennis Schroeder, NREL R&D 100 Awards Demonstrate Clean Energy Legacy NREL has won 57 R&D 100 Awards since 1982, many of which led directly to industry successes today. R&D 100

Evaluating firms’ R&D performance using best worst method

NARCIS (Netherlands)

Salimi, Negin; Rezaei, J.

2018-01-01

Since research and development (R&D) is the most critical determinant of the productivity, growth and competitive advantage of firms, measuring R&D performance has become the core of attention of R&D managers, and an extensive body of literature has examined and identified different

Industrial influences on R&D transfer to China

DEFF Research Database (Denmark)

Søberg, Peder Veng

2010-01-01

, and innovation theory, which is illustrated in two cases from globally leading MNCs from different industries and technological fields which have established R&D units in China. It addresses the issue of industrial influences on R&D transfer to emerging markets, and the importance of complementary assets...... the argument that complementary assets are important for R&D in emerging markets. Implications for management in China are outlined. The term captive knowledge transfer is coined....

An R&D Management Framework for Eco-Technology

OpenAIRE

Hideki Kobayashi; Masahiro Kato; Yukishige Maezawa; Kenji Sano

2011-01-01

Although research and development (R&D) affects new value-added creation, including that related to environmental aspects, there is little literature dealing with the integration of R&D management and eco-value. Here, eco-value of technology is defined as the advantage of environmental competitiveness in the market. This paper proposes a framework of R&D management of eco-technology (RDMOET), consisting of: (1) future research for sustainability; (2) making an original eco-theme p...

Stability Analysis of R&D Cooperation in a Supply Chain

Directory of Open Access Journals (Sweden)

Luyun Xu

2015-01-01

Full Text Available R&D outsourcing becomes the often-adopted strategy for firms to innovate. However, R&D cooperation often ends up with failure because of its inherent quality of instability. One of the main reasons for cooperation failure is the opportunistic behavior. As the R&D contract between firms is inherently incomplete, opportunistic behavior always cannot be avoided in the collaborative process. R&D cooperation has been divided into horizontal and vertical types. This paper utilizes game theory to study opportunistic behavior in the vertical R&D cooperation and analyzes the equilibrium of the cooperation. Based on the equilibrium and numerical results, it is found that the vertical R&D cooperation is inherently unstable, and the downstream firm is more likely to break the agreement. The level of knowledge spillovers and the cost of R&D efforts have different effects on firms’ payoffs. When the level of knowledge spillover is low or the cost of R&D efforts is high, mechanisms such as punishment for opportunism may be more effective to guarantee the stability of cooperation.

Managing uncertainty during r&d projects: a case study

NARCIS (Netherlands)

Wouters, Marc; Roorda, Berend; Gal, Ruud

2011-01-01

Firms make signifi cant investments in R&D projects, yet the economic return is often diffi cult to predict because of signifi cant technological and commercial uncertainty. We present an innovative and practical method for managing R&D projects, and we discuss its application to a large R&D

Export performance and Investment in R&D

DEFF Research Database (Denmark)

Dilling-Hansen, Mogens; Madsen, Erik Strøjer; Schröder, Philipp

Export and R&D behavior are endogenous and interact in a non-trivial manner with each other. Subsequently an empirical model for export and R&D behavior is formulated taking account of, inter alia, firm size, wages, human capital and a number of other firm and industry specific factors...

IBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA.

Science.gov (United States)

Klöhn, Peter-Christian; Wuellner, Ulrich; Zizlsperger, Nora; Zhou, Yu; Tavares, Daniel; Berger, Sven; Zettlitz, Kirstin A; Proetzel, Gabriele; Yong, May; Begent, Richard H J; Reichert, Janice M

2013-01-01

The 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences, and the 2012 Annual Meeting of The Antibody Society, organized by IBC Life Sciences with contributions from The Antibody Society and two Scientific Advisory Boards, were held December 3-6, 2012 in San Diego, CA. The meeting drew over 800 participants who attended sessions on a wide variety of topics relevant to antibody research and development. As a prelude to the main events, a pre-conference workshop held on December 2, 2012 focused on intellectual property issues that impact antibody engineering. The Antibody Engineering Conference was composed of six sessions held December 3-5, 2012: (1) From Receptor Biology to Therapy; (2) Antibodies in a Complex Environment; (3) Antibody Targeted CNS Therapy: Beyond the Blood Brain Barrier; (4) Deep Sequencing in B Cell Biology and Antibody Libraries; (5) Systems Medicine in the Development of Antibody Therapies/Systematic Validation of Novel Antibody Targets; and (6) Antibody Activity and Animal Models. The Antibody Therapeutics conference comprised four sessions held December 4-5, 2012: (1) Clinical and Preclinical Updates of Antibody-Drug Conjugates; (2) Multifunctional Antibodies and Antibody Combinations: Clinical Focus; (3) Development Status of Immunomodulatory Therapeutic Antibodies; and (4) Modulating the Half-Life of Antibody Therapeutics. The Antibody Society's special session on applications for recording and sharing data based on GIATE was held on December 5, 2012, and the conferences concluded with two combined sessions on December 5-6, 2012: (1) Development Status of Early Stage Therapeutic Antibodies; and (2) Immunomodulatory Antibodies for Cancer Therapy.

Half the Nation's R&D Concentrated in Six States. InfoBrief.

Science.gov (United States)

Bennof, Richard J.

This document presents research and development (R&D) expenditures reported by state based on data from the year 1999 in the United States. Information includes R&D expenditures by state, sector distribution of R&D performance by state, ratio of R&D to gross state product, and federal support for R&D by state. (YDS)

A Duopoly Experiment on Cooperative and Noncooperative R&D

NARCIS (Netherlands)

Suetens, S.

2003-01-01

In this paper an experimental environment to test theoretical predictions concerning R&D behavior of firms in duopoly with allowance for R&D spillovers is created. The design and hypotheses of the experiment are based on the well-known model of d Aspremont and Jacquemin in which R&D behavior of

Project Selection for NASA's R&D Programs

Science.gov (United States)

Jones, Harry

2005-01-01

The purpose of NASA s Research and Development (R&D) programs is to provide advanced human support technologies for the Exploration Systems Mission Directorate (ESMD). The new technologies must be sufficiently attractive and proven to be selectable for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are likely options for flight. The R&D programs must select an array of technology development projects, manage them, and either terminate or continue them, so as to maximize the delivered number of potentially usable advanced human support technologies. This paper proposes an effective project selection methodology to help manage NASA R&D project portfolios.

Structural and Infrastructural Underpinnings of International R&D Networks

DEFF Research Database (Denmark)

Niang, Mohamed; Sørensen, Brian Vejrum

2009-01-01

This paper explores the process of globally distributing R&D activities with an emphasis on the effects of network maturity. It discusses emerging configurations by asking how the structure and infrastructure of international R&D networks evolve along with the move from a strong R&D center...... to dispersed development. Drawing from case studies of two international R&D networks, it presents a capability maturity model and argues that understanding the interaction between new structures and infrastructures of the dispersed networks has become a key requirement for developing organizational...

Results from the UK 3rd generation programme: Albion

Science.gov (United States)

McEwen, R. K.; Axcell, C.; Knowles, P.; Hoade, K. P.; Wilson, M.; Dennis, P. N. J.; Backhouse, P.; Gordon, N. T.

2008-10-01

Following the development of 1st Generation systems in the 1970s, thermal imaging has been in service with the UK armed forces for over 25 years and has proven itself to be a battle winning technology. More recently the wider accessibility to similar technologies within opposing forces has reduced the military advantage provided by these 1st Generation systems and a clear requirement has been identified by the UK MOD for thermal imaging sensors providing increased detection, recognition and identification (DRI) ranges together with a simplified logistical deployment burden and reduced through-life costs. In late 2005, the UK MOD initiated a programme known as "Albion" to develop high performance 3rd Generation single waveband infrared detectors to meet this requirement. At the same time, under a separate programme supporting higher risk technology, a dual waveband infrared detector was also developed. The development phase of the Albion programme has now been completed and prototype detectors are now available and have been integrated into demonstration thermal imaging cameras. The Albion programme has now progressed into the second phase, incorporating both single and dual waveband devices, focussing on low rate initial production (LRIP) and qualification of the devices for military applications. All of the detectors have been fabricated using cadmium mercury telluride material (CMT), grown by metal organic vapour phase epitaxy (MOVPE) on low cost, gallium arsenide (GaAs) substrates and bump bonded to the silicon read out circuit (ROIC). This paper discusses the design features of the 3rd Generation detectors developed in the UK together with the results obtained from the prototype devices both in the laboratory and when integrated into field deployable thermal imaging cameras.

33rd International Conference on the Physics of Semiconductors

International Nuclear Information System (INIS)

2017-01-01

Preface to the Proceedings of the 33rd International Conference on the Physics of Semiconductors, Beijing, 2016 Shaoyun Huang 1 , Yingjie Xing 1 , Yang Ji 2 , Dapeng Yu 3 , and Hongqi Xu 1 1 Beijing Key Laboratory of Quantum Devices, Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics, Peking University, Beijing 100871, China 2 SKLSM, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China 3 State Key Laboratory for Mesoscopic Physics, Department of Physics, Peking University, Beijing 100871, China From July 31 st to August 5 th , 2016, the 33rd International Conference on the Physics of Semiconductors (ICPS 2016) was held in Beijing, China, with a great success. The International Conference on the Physics of Semiconductors began in the 1950’s and is a premier biennial meeting for reporting all aspects of semiconductor physics including electronic, structural, optical, magnetic and transport properties. Reflecting the state of the art developments in semiconductor physics, ICPS 2016 served as an international forum for scholars, researchers, and specialists across the globe to discuss future research directions and technological advancements. The main topics of ICPS 2016 included: • Material growth, structural properties and characterization, phonons • Wide-bandgap semiconductors • Narrow-bandgap semiconductors • Carbon: nanotubes and graphene • 2D Materials beyond graphene • Organic semiconductors • Topological states of matter, topological Insulators and Weyl semimetals • Transport in heterostructures • Quantum Hall effects • Spintronics and spin phenomena • Electron devices and applications • Optical properties, optoelectronics, solar cells • Quantum optics, nanophotonics • Quantum information • Other topics in semiconductor physics and devices • Special topic: Majorana fermions in solid state (paper)

Meeting of the Chemical Societies: Almanac of the contributions of the fifty-third meeting of the chemical societies, Vol. 3

International Nuclear Information System (INIS)

Toelgyessy, J.

2001-09-01

The publication has been set up as the abstracts of the meeting dealing with different chemical problems. The book (Vol. 3) consists of the sections: (F) Chemistry of polymers, organic materials, textile, fibres, foil materials (63 papers); (I) Organic and pharmaceutical chemistry (59 papers); (J) Food chemistry and biotechnology (26 papers); (M) Environment, Toxicology (51 papers)

The analysis of market knowledge competence effect and research & development (R&D) toward the policy making of new product development

Science.gov (United States)

Purwanggono, Bambang; Sesuko, Agung; Budiawan, Wiwik

2017-11-01

The increasing mobility of people without adequate provision of mass transportation infrastructures makes people choose private transportation like motorcycles. Such circumstances lead the motorcycle manufacturers in Indonesia competing to develop their products to meet the needs of customers. In addition, the new regulation of Central Bank of Indonesia dealing with the credit advances has raised the intense competition of motorcycles industries in Indonesia. One of the ways to win the competition is by developing new and improved products. In developing and improving the products, companies need to consider resource utilization. In this research, researcher utilizes the resources that exist both inside and outside the enterprise such as customer demands, intensity of competition, perception of the importance of market knowledge, importance of market competence, and internal R&D as well as external R&D is expected to develop new products that are superior. The study involved 150 employees as respondents. The method used in the study is Structural Equation Modeling (SEM) with AMOS 20.0 statistical software. The result shows that the demands of the customers and the intensity of competition lead to a positive effect on market knowledge competence, while the perception of the market knowledge importance does not influence the development of new products, and market knowledge competence, internal R&D and external R&D have positive effect on the development of new products.

R&D Personnel Career Routes: An Exploratory Study

OpenAIRE

Barbara Bigliardi; Alberto Ivo Dormio

2009-01-01

This study, aiming at investigate the alternative modes of career development for personnel belonging to R&D staff, addresses the extent to which career anchors are applicable to R&D staff and to examine the relationship among career anchors, gender and age, with the final purpose to add elements of discussion to the long-lasting debate about this matter. With this purpose in mind, we developed a questionnaire survey among 309 R&D personnel employed at firms belonging to the food machinery in...

Global Gaps in Clean Energy RD and D

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

This report seeks to inform decision makers seeking to prioritise RD&D investments in a time of financial uncertainty. It is an update of the December 2009 IEA report Global Gaps in Clean Energy Research, Development and Demonstration, which examined whether rates of LCET investment were sufficient to achieve shared global energy and environmental goals (IEA,2009). It discusses the impact of the green stimulus spending announcements, and provides private sector perspectives on priorities for government RD&D spending. Finally, it includes a revised assessment of the gaps in public RD&D, together with suggestions for possible areas for expanded international collaboration on specific LCETs. The conclusion re-affirms the first Global Gaps study finding that governments and industry need to dramatically increase their spending on RD&D for LCETs.

40 CFR 63.1446 - What alternative emission limitation may I meet for my combined gas streams?

Science.gov (United States)

2010-07-01

... than a baghouse or venturi wet scrubber applied to meet any total particulate matter emission limit in... than 5 percent of the total operating time in any semiannual reporting period. (d) For each venturi wet scrubber applied to meet any total particulate matter emission limit in paragraph (b) of this section, you...

FDI in R&D in India: An Introspection

OpenAIRE

POHIT, Sanjib; BISWAS, Pradip

2016-01-01

 Abstract. Of late, India has emerged as an attractive destination of foreign direct investment (FDI).  Along with it, multinationals have been investing significantly in research and development in India. In this context, this paper makes an attempt to analyze salient features of FDI in R&D and makes an assessment of the gains from R&D initiatives of MNCs in India. To be specific, the paper attempts to demystify the FDI flows in R&D with a view to understand whether these types o...

Trends in the Internationalisation of R&D - the German Perspective

OpenAIRE

Marian Beise; Heike Belitz

1998-01-01

In this paper we present latest facts about the R&D activities of German multinational companies abroad and R&D activities of foreign companies in Germany. These results confirm that Germany is still an attractive location for R&D activites of multinational companies in many technological fields. However, the internationalisation of R&D is closely linked with the internationalisation of sales and production. In the commonly accepted eclectic theoretical approach by Dunning direct investment i...

Temporal variation of gravity field prior to the Ludian Ms6.5 and Kangding Ms6.3 earthquakes

OpenAIRE

Hao, Hongtao; Wei, Jin; Hu, Minzhang; Liu, Ziwei; Li, Hui

2015-01-01

Using mobile gravity data from the central area of Sichuan and Yunnan Provinces, the relationship between gravity variation and earthquakes was studied based on the Ludian Ms6.5 earthquake that occurred on August 3rd, 2014, and the Kangding Ms6.3 earthquake that occurred on November 22nd, 2014; the mechanism of gravity variation was also explored. The results are as follows: (1) Prior to both earthquakes, gravity variation exhibited similar characteristics as those observed before both the Ta...

R&D Collaboration with Uncertain Intellectual Property Rights

DEFF Research Database (Denmark)

Czarnitzki, Dirk; Hussinger, Katrin; Schneider, Cédric

2015-01-01

—uncertain intellectual property rights (IPRs) lead to reduced collaboration between firms and can, hence, hinder knowledge production. This has implications for technology policy as R&D collaborations are exempt from antitrust legislation in order to increase R&D in the economy. We argue that a functional IPR system......Patent pendencies create uncertainty in research and development (R&D) collaboration, which can result in a threat of expropriation of unprotected knowledge, reduced bargaining power and enhanced search costs. We show that—depending of the type of collaboration partner and the size of the company...

R&D Collaboration with Uncertain Intellectual Property Rights

DEFF Research Database (Denmark)

Czarnitzki, Dirk; Hussinger, Katrin; Schneider, Cédric

- uncertain intellectual property rights (IPR) lead to reduced collaboration between firms and may hinder the production of knowledge. This has implications for technology policy as R&D collaborations are exempt from anti-trust legislation in order to increase R&D in the economy. We argue that a functional......Patent pendencies create uncertainty in research and development (R&D) collaboration agreements, resulting in a threat of expropriation of unprotected knowledge by potential partners, reduced bargaining power and enhanced search costs. In this paper, we show that - depending of the type of partner...

Persistence of monopoly, innovation, and R&D spillovers

Czech Academy of Sciences Publication Activity Database

Kováč, E.; Žigić, Krešimir

2016-01-01

Roč. 70, č. 4 (2016), s. 714-734 ISSN 1090-9443 R&D Projects: GA ČR GA15-24642S Institutional support: RVO:67985998 Keywords : dynamic duopoly * R&D spillovers * persistence of monopoly Subject RIV: AH - Economics

Evaluation of the Norwegian R&D Tax Credit Scheme

Directory of Open Access Journals (Sweden)

Ådne Cappelen

2010-11-01

Full Text Available We find that the Norwegian R&D tax credit scheme introduced in 2002 mainly works as intended. The scheme is cost-effective and it is used by a large number of firms. It stimulates these firms to invest more in R&D, and, in particular, the effect is positive for small firms with little R&D experience. The returns on the R&D investments supported by the scheme are positive and generally not different from the returns to other R&D investments. We have found examples of what can be interpreted as tax motivated adjustments to the scheme, but to some extent this must be accepted as a cost to subsidy and support schemes intended for use by a large number of economic agents. This is particularly so when attempts are made to keep administrative expenditures and control routines at a low level.

Governance Models of R&D Offshoring: : Innovatoin Performance and Absorptive Capacity

NARCIS (Netherlands)

Steinberg, Philip; Procher, Vivien D.

2015-01-01

The globalization of business functions has led to an increase in offshoring of R&D. Firms’ offshoring models of R&D include captive offshoring (foreign R&D spending to affiliates) and offshore outsourcing (foreign R&D spending to external partners). For 2,421 R&D-active German enterprises we

R&D; towards future upgrade of the CMS RPC system

CERN Document Server

Pugliese, Gabriella

2016-01-01

The CMS experiment at the CERN Large Hadron Collider (LHC) is equipped with a redundant muon trigger system based on Drift Tubes Chambers (DT) in the barrel region and Cathode Strip Chamber (CSC) in the endcap regions and Resistive Plate Chambers (RPC) in both regions up to | η | = 1.6. In view of the High Luminosity LHC (HL-LHC) phase, to keep the same muon performance new muon stations will be installed in the forward region (1.6< | η | <2.4) and in the very forward region up to | η | = 2.8. The 3th and 4th stations will be equipped with a new generation of RPC with improved performance (iRPC), capable of handling the challenging con- ditions expected at the HL-LHC. An extensive R&D; program has been undertaken to define the detector design and related electronics that meet the HL-LHC requirements. A summary of iRPC performance results is here reported.

R&D EXPENDITURES AND EARNINGS TARGETS: EVIDENCE FROM FRANCE

OpenAIRE

Guidara, Rihab; Boujelbene, Younes

2015-01-01

Research and development (R&D) investments reduce current-period earnings while the benefits associated with the investments occur in the future. This problem implies an earnings management tool to boost short-term performance. While there is much evidence regarding managerial discretion through R&D capitalization, empirical studies that directly examine managerial discretion through R&D expenditure adjusting have not been widely provided in the European context. This ...

God Adfærd i Videnskaberne

DEFF Research Database (Denmark)

Hansen, Vagn Lundsgaard

2006-01-01

Hvad er videnskabelig uredelighed? Hvordan håndterer man problemet? Hvordan forebygger man det? De tre spørgsmål diskuteres i et internationalt perspektiv med forkus på veje til at opnå og opretholde god adfærd i videnskaberne.......Hvad er videnskabelig uredelighed? Hvordan håndterer man problemet? Hvordan forebygger man det? De tre spørgsmål diskuteres i et internationalt perspektiv med forkus på veje til at opnå og opretholde god adfærd i videnskaberne....

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 72, Revision 1 (FGE.72Rev1): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... threshold of concern, and available data on metabolism and toxicity. The Panel agrees with the application of the Procedure as performed by the JECFA for all 23 substances considered in this FGE and agrees with the JECFA conclusion, “No safety concern at estimated levels of intake as flavouring substances......” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 23 substances, the information is adequate...

78 FR 20167 - 33rd Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

Science.gov (United States)

2013-04-03

... Other Business Sub-Groups meetings Break out, as necessary daily EDR Turbulence Standards Project Briefing from FAA SE2020 Team SG6 WG1 Architecture and MASPS presentations SG3 AIS and MET Services Delivery Architecture Recommendations Document Review (FRAC release approval). Closing Plenary--Sub-Groups...

Energy technology R&D portfolio management: Modeling uncertain returns and market diffusion

International Nuclear Information System (INIS)

Bistline, John E.

2016-01-01

Highlights: • Analyzes energy R&D decisions with uncertainty in research outcomes and markets. • R&D is shown to be more valuable in second-best planning and policy environments. • Deterministic R&D approaches likely undervalue the optionality of technologies. - Abstract: The allocation of research and development (R&D) funds across a portfolio of programs must simultaneously consider uncertainty from research outcomes and from market acceptance of the resulting technologies. We introduce a stochastic R&D portfolio management framework for addressing both sources of uncertainty and present numerical results for energy technology R&D strategy under uncertainties in climate policy and natural gas prices. Numerical experiments indicate that R&D may be more valuable in second-best planning environments where decision-makers use expected-value approaches, and recourse investments occur after R&D has reduced costs. We also find that deterministic R&D valuation approaches likely overestimate the expected value of R&D success but undervalue the optionality and hedging potential of technologies relative to sequential decision-making approaches under uncertainty. The results also highlight the role of R&D in second-best policy environments.

R&D EXPENDITURES AND EARNINGS TARGETS: EVIDENCE FROM FRANCE

OpenAIRE

Guidara, Rihab; Boujelbene, Younes

2015-01-01

Research and development (R&D) investments reduce current-period earnings while the benefits associated with the investments occur in the future. This problem implies an earnings management tool to boost short-term performance. While there is much evidence regarding managerial discretion through R&D capitalization, empirical studies that directly examine managerial discretion through R&D expenditure adjusting have not been widely provided in the European context. This paper seeks ...

Transcriptional regulation of ABI3- and ABA-responsive genes including RD29B and RD29A in seeds, germinating embryos, and seedlings of Arabidopsis.

Science.gov (United States)

Nakashima, Kazuo; Fujita, Yasunari; Katsura, Koji; Maruyama, Kyonoshin; Narusaka, Yoshihiro; Seki, Motoaki; Shinozaki, Kazuo; Yamaguchi-Shinozaki, Kazuko

2006-01-01

ABA-responsive elements (ABREs) are cis-acting elements and basic leucine zipper (bZIP)-type ABRE-binding proteins (AREBs) are transcriptional activators that function in the expression of RD29B in vegetative tissue of Arabidopsis in response to abscisic acid (ABA) treatment. Dehydration-responsive elements (DREs) function as coupling elements of ABRE in the expression of RD29A in response to ABA. Expression analysis using abi3 and abi5 mutants showed that ABI3 and ABI5 play important roles in the expression of RD29B in seeds. Base-substitution analysis showed that two ABREs function strongly and one ABRE coupled with DRE functions weakly in the expression of RD29A in embryos. In a transient transactivation experiment, ABI3, ABI5 and AREB1 activated transcription of a GUS reporter gene driven by the RD29B promoter strongly but these proteins activated the transcription driven by the RD29A promoter weakly. In 35S::ABI3 Arabidopsis plants, the expression of RD29B was up-regulated strongly, but that of RD29A was up-regulated weakly. These results indicate that the expression of RD29B having ABREs in the promoter is up-regulated strongly by ABI3, whereas that of RD29A having one ABRE coupled with DREs in the promoter is up-regulated weakly by ABI3. We compared the expression of 7000 Arabidopsis genes in response to ABA treatment during germination and in the vegetative growth stage, and that in 35S::ABI3 plants using a full-length cDNA microarray. The expression of ABI3- and/or ABA-responsive genes and cis-elements in the promoters are discussed.

33rd Annual conference and the 23rd annual theoretical seminar of the South African Institute of Physics

International Nuclear Information System (INIS)

1988-01-01

The 33rd annual conference and the 23rd annual theoretical seminar of the South African Institute of Physics was held from 4-8 July 1988 at Rhodes University, Grahamstown. This publication contains only the abstracts of seminars delivered on the conference. The topics that were covered include the various facets of physics such as solid state physics, nuclear and particle physics, optics and spectroscopy, solar-terrestrial physics, eduction, and applied and industrial physics

Developing R&D portfolio business validity simulation model and system.

Science.gov (United States)

Yeo, Hyun Jin; Im, Kwang Hyuk

2015-01-01

The R&D has been recognized as critical method to take competitiveness by not only companies but also nations with its value creation such as patent value and new product. Therefore, R&D has been a decision maker's burden in that it is hard to decide how much money to invest, how long time one should spend, and what technology to develop which means it accompanies resources such as budget, time, and manpower. Although there are diverse researches about R&D evaluation, business factors are not concerned enough because almost all previous studies are technology oriented evaluation with one R&D technology based. In that, we early proposed R&D business aspect evaluation model which consists of nine business model components. In this research, we develop a simulation model and system evaluating a company or industry's R&D portfolio with business model point of view and clarify default and control parameters to facilitate evaluator's business validity work in each evaluation module by integrate to one screen.

PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

Science.gov (United States)

Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji

2010-09-01

The structures, physicochemical and thermodynamic properties of materials are becoming increasingly amenable to treatment by first-principles (ab initio) quantum mechanical simulations. Calculations containing a few hundred atoms are now routine, thanks to improvements in computer technology and computational techniques. Schemes to determine electronic structures more accurately and to treat more complex systems continue to be developed. A growing number of scientists and engineers are becoming aware of the power of these approaches. By applying these new computational tools, materials science and technology is expected to enter a new era of accelerated progress and efficiency. In 1998 the first workshop entitled 'Theory Meets Industry' (TMI) was held at the Vienna University of Technology. The aim of the workshop was to direct the potential of the ab initio simulation codes developed in academia towards the necessities arising from industrial research. Over the next decade, significant advances in ab initio methodology and its application to academic and industrial research were achieved. It was thus considered timely to hold a second TMI workshop in 2007, again in Vienna. The contributions from academia concentrated on a wide range of new developments in ab initio simulations, as well as on applications at the forefront of materials research. Speakers from the industrial sector also emphasized the progress made in successfully applying ab initiotechniques to key areas of modern technology. The proceedings were published in Journal of Physics: Condensed Matter as a special issue (volume 20, number 6, 2008), which was included in the 'Top papers 2008 showcase' of that journal. Following the notable success of the first two workshops, it was decided that the third TMI workshop would be held outside Europe. Holding the workshop in Japan was intended to increase awareness of theoretical materials science and foster further international collaboration in this field

40 CFR 63.1312 - Definitions.

Science.gov (United States)

2010-07-01

... continuous process vent and a batch process vent. Combustion device burner means a device designed to mix and...) Research and development facility (§ 63.101) Routed to a process or route to a process (§ 63.161) Run (§ 63... vessel (§ 63.161) Temperature monitoring device (§ 63.111) Test method (§ 63.2) Treatment process (§ 63...

Summary of findings of the R&D committee

Energy Technology Data Exchange (ETDEWEB)

Kenley, C.R. [Lockheed Martin Idaho Technologies, Idaho Falls (United States); Kokenge, B.R. [BRK Associates Inc., Farmersville, OH (United States)

1996-05-01

In March 1995, the Department of Energy`s (DOE) Nuclear Materials Stabilization Task Group (NMST) chartered a committee to formulate a research and development (R&D) plan in response to Sub-recommendation (2) of Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. The NMSTG was established as an organizational unit operating under the auspices of the DOE Office of the Environmental Management. As a result of its efforts, the Research Committee concluded that, in general, the technology needs for stabilizing 94-1 nuclear materials are being adequately met by existing or planned DOE programs. At the same time, the committee, in the form of recommendations, noted specific R&D program areas that should be addressed by the NMSTG. These recommendations are documented in the R&D plan and formulated based on: (1) existing {open_quotes}gaps{close_quotes} in DOE`s R&D stabilization program, (2) the relative maturity of various technologies, and (3) other important R&D program issues that, in the judgement of the committee, should be addressed by the NMSTG. A systems engineering approach, derived form the aerospace industry, was applied to the various stabilization technologies to assess their relative maturity and availability for use in treating 94-1 nuclear materials.

Forty-Fourth Meeting of the Technical Working Group on Fast Reactors (TWG-FR). Working Material

International Nuclear Information System (INIS)

2011-01-01

The objectives of the meeting were to: - Exchange information on the national programmes on Fast Reactors (FR) and Accelerator Driven Systems (ADS); - Review the progress since the 43rd TWG-FR Annual Meeting, including the status of the actions; - Consider topical technical meeting arrangements for 2012-2013, as well as review FR-related activities included in the IAEA Project&Budget (P&B) biennium 2012-2013; - Review the IAEA’s ongoing information exchange and coordinated research projects in the technical fields relevant to the TWG-FR (FRs and ADS), as well as coordination of the TWG-FR’s activities with other organizations and international initiatives (GIF, INPRO, NEA, ESNII, etc.)

3rd Annual Earth System Grid Federation and 3rd Annual Earth System Grid Federation and Ultrascale Visualization Climate Data Analysis Tools Face-to-Face Meeting Report December 2013

Energy Technology Data Exchange (ETDEWEB)

Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2014-02-21

The climate and weather data science community gathered December 3–5, 2013, at Lawrence Livermore National Laboratory, in Livermore, California, for the third annual Earth System Grid Federation (ESGF) and Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT) Face-to-Face (F2F) Meeting, which was hosted by the Department of Energy, National Aeronautics and Space Administration, National Oceanic and Atmospheric Administration, the European Infrastructure for the European Network of Earth System Modelling, and the Australian Department of Education. Both ESGF and UV-CDAT are global collaborations designed to develop a new generation of open-source software infrastructure that provides distributed access and analysis to observed and simulated data from the climate and weather communities. The tools and infrastructure developed under these international multi-agency collaborations are critical to understanding extreme weather conditions and long-term climate change, while the F2F meetings help to build a stronger climate and weather data science community and stronger federated software infrastructure. The 2013 F2F meeting determined requirements for existing and impending national and international community projects; enhancements needed for data distribution, analysis, and visualization infrastructure; and standards and resources needed for better collaborations.

Citizen involvement in future drug R&D

DEFF Research Database (Denmark)

Møldrup, Claus; Morgall, Janine Marie; Almarsdóttir, Anna Birna

2000-01-01

This article adopts a prospective approach in an attempt to explore the potential benefit of citizen involvement in decision making concerning future drug R&D. This is one of the first Delphi studies to fully utilize internet technology to collect and process data. The results show an increasing...... individual autonomy among respondents, which also affects the drug R&D process in general. Human, liberal and ethical values are reported as crucial values to citizens. On this basis, respondents reported that patient organizations, representative citizen groups and ethical councils can contribute...... with important input to ensure these values in decision making concerning future drug R&D. Paying attention to citizen needs, demands and ideas may protect the research, development and eventual marketing of unacceptable drugs on a societal and ethical level....

The Growth Effects of R&D Spending in the EU

DEFF Research Database (Denmark)

Kokko, Ari; Tingvall, Patrik Gustavsson; Videnord, Josefin

private sector investment in R&D and stronger public-private sector linkages than in the EU. Hence, to reduce the “innovation gap” vis-à-vis the US, it may not be enough for the EU to raise the share of R&D expenditures in GDP: continuous improvements in the European innovation system will also be needed......, with focus on areas like private sector R&D and public-private sector linkages.......In this paper we conduct a meta-analysis to examine the link between R&D spending and economic growth in the EU and other regions. The results suggest that the growth-enhancing effect of R&D in the EU15 countries does not differ from that in other countries in general, but it is less significant...

The Growth Effects of R&D Spending in the EU

DEFF Research Database (Denmark)

Kokko, Ari; Tingvall, Patrik Gustavsson; Videnord, Josefin

2015-01-01

private sector investment in R&D and stronger public-private sector linkages than in the EU. Hence, to reduce the “innovation gap” vis-à-vis the US, it may not be enough for the EU to raise the share of R&D expenditures in GDP: continuous improvements in the European innovation system will also be needed......, with focus on areas like private sector R&D and public-private sector linkages.......In this paper we conduct a meta-analysis to examine the link between R&D spending and economic growth in the EU and other regions. The results suggest that the growth-enhancing effect of R&D in the EU15 countries does not differ from that in other countries in general, but it is less significant...

40 CFR 63.482 - Definitions.

Science.gov (United States)

2010-07-01

... designed to mix and ignite fuel and air to provide a flame to heat and oxidize waste organic vapors in a...) Research and development facility (§ 63.101) Routed to a process or route to a process (§ 63.161) Run (§ 63... vessel (§ 63.161) Temperature monitoring device (§ 63.111) Test method (§ 63.2) Treatment process (§ 63...

International R&D collaboration networks and free trade agreements

OpenAIRE

Song, Hua Sheng

2006-01-01

This thesis contributes to the analysis of optimal industrial and strategic trade policy in the presence of oligopoly and other forms of imperfect competition, so as to make contact with important empirical regularities and policy concerns, such as international R&D collaboration, unionization and free trade. First, in the context of international competition in which R&D plays an important role, we study the consequences of allowing governments to subsidize R&D and coalition devi...

Institutional Influences on R&D Collaboration in China

DEFF Research Database (Denmark)

Søberg, Peder Veng

2014-01-01

that simultaneously builds trust in the sequence of affect-based trust followed by cognition-based trust. Thereby, good results can be created in collaboration with Chinese universities. The paper illustrates institutional influences on R&D collaboration between foreign invested R&D and local universities in China...

Critical issues facing R&D managers in China

NARCIS (Netherlands)

de Boer, S.J.; Gan, Weibing; Shan, Guogang

1998-01-01

R&D managers in China experienced significant changes in the past decade, in particular because of Government policies of economic reform and opening to the outside world. These developments have brought about a number of rather specific R&D management issues and problems. The paper addresses the

Civilsamfundets ABC: V for Velfærd

DEFF Research Database (Denmark)

Meyer, Gitte; Lund, Anker Brink

2016-01-01

Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til V for Velfærd.......Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til V for Velfærd....

A Note on R&D and Price Elasticity of Demand

DEFF Research Database (Denmark)

Schröder, Philipp J.H.; Schumacher, Dieter; Lucke, Dorothea

2005-01-01

This note explores the relationship between the price elasticity of demand and the R&D intensity of the product. We introduce the concept of R&D intensity into a standard Dixit-Stiglitz/Krugman-type setting. R&D activity is treated as a fixed cost of production. Within this framework, sectors...... with a higher R&D intensity show a lower price elasticity of demand. This proposition is confirmed by an empirical investigation of export demand for manufactured goods from major industrialised countries. Consequently, real exchange rate changes have an impact on the commodity structure of exports....

40 CFR 63.300 - Applicability.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Applicability. 63.300 Section 63.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Oven Batteries § 63.300 Applicability. (a) Unless otherwise specified in §§ 63.306, 63.307, and 63.311...

How Reverse R&D Knowledge Transfer from Foreign Invested R&D in Emerging Markets Can Drive Global Innovation Performance

DEFF Research Database (Denmark)

Søberg, Peder Veng; Harryson, Sigvald

2010-01-01

is that Windtech took a more open collaboration approach towards other local companies – typically R&D Centers of Western leading companies in relevant industries. This open recruiting policy provided the platform for locally created innovations with global innovation impact....... efforts. A network based theoretical framework is introduced to analyze and explain the impact of globalization of R&D on innovation performance – mainly as a result of local connectivity. Empirically, we explore four company cases to analyze the extent to which their strategic expansion of R&D activities......&D to China. Their university interaction was quite monolateral, mainly based on Robotech donating equipment for university researchers to experiment with. Like Robotech, Windtech did not engage in bilateral university collaborations. One point of differentiation from all other three case companies...

Developing Product Lines with 3rd-party components

NARCIS (Netherlands)

De Jonge, M.

2007-01-01

The trends toward product line development and toward adopting more 3rd-party software are hard to combine. The reason is that productlines demand fine control over the software (e.g., for diversity management), while 3rd-party software (almost by definition) provides only little or no control. A

RD-674B/UNH and RD-68lA/UNH Recorder-Reproducer Information Sheets

National Research Council Canada - National Science Library

Durkin, Matthew

2000-01-01

.... The system can be housed in a standard ElA cabinet with a 19-inch rack configuration. A major advantage of the RD-68IA/UNH is that audio recording need not be interrupted to provide simultaneous...

Resource Allocation of Agricultural Science and Technology R&D

OpenAIRE

Li, Xian-song; Bai, Li; Zhang, Li-ming

2011-01-01

The status quo of resource allocation of agricultural science and technology R&D (research and development)both at home and abroad，including the amount and function of agricultural science and technology research funds, human resources in the resources of agricultural science and technology R&D , the efficiency of resource allocation of agricultural science and technology R&D, the management system of agricultural scientific innovation and the operation status of scientific funds, is analyz...

40 CFR 63.1402 - Definitions.

Science.gov (United States)

2010-07-01

...; (ii) Water from fire-fighting and deluge systems in segregated sewers; (iii) Spills; (iv) Water from... (§ 63.111) Annual average flow rate (§ 63.111) Automated monitoring and recording system (§ 63.111....111) Closed-vent system (§ 63.111) Combustion device (§ 63.111) Commenced (§ 63.2) Compliance date...

Developing R&D Portfolio Business Validity Simulation Model and System

Directory of Open Access Journals (Sweden)

Hyun Jin Yeo

2015-01-01

Full Text Available The R&D has been recognized as critical method to take competitiveness by not only companies but also nations with its value creation such as patent value and new product. Therefore, R&D has been a decision maker’s burden in that it is hard to decide how much money to invest, how long time one should spend, and what technology to develop which means it accompanies resources such as budget, time, and manpower. Although there are diverse researches about R&D evaluation, business factors are not concerned enough because almost all previous studies are technology oriented evaluation with one R&D technology based. In that, we early proposed R&D business aspect evaluation model which consists of nine business model components. In this research, we develop a simulation model and system evaluating a company or industry’s R&D portfolio with business model point of view and clarify default and control parameters to facilitate evaluator’s business validity work in each evaluation module by integrate to one screen.

Developing R&D Portfolio Business Validity Simulation Model and System

Science.gov (United States)

2015-01-01

The R&D has been recognized as critical method to take competitiveness by not only companies but also nations with its value creation such as patent value and new product. Therefore, R&D has been a decision maker's burden in that it is hard to decide how much money to invest, how long time one should spend, and what technology to develop which means it accompanies resources such as budget, time, and manpower. Although there are diverse researches about R&D evaluation, business factors are not concerned enough because almost all previous studies are technology oriented evaluation with one R&D technology based. In that, we early proposed R&D business aspect evaluation model which consists of nine business model components. In this research, we develop a simulation model and system evaluating a company or industry's R&D portfolio with business model point of view and clarify default and control parameters to facilitate evaluator's business validity work in each evaluation module by integrate to one screen. PMID:25893209

CANDU Safety R&D Status, Challenges, and Prospects in Canada

Directory of Open Access Journals (Sweden)

W. Shen

2015-01-01

Full Text Available In Canada, safe operation of CANDU (CANada Deuterium Uranium; it is a registered trademark of Atomic Energy of Canada Limited reactors is supported by a full-scope program of nuclear safety research and development (R&D in key technical areas. Key nuclear R&D programs, facilities, and expertise are maintained in order to address the unique features of the CANDU as well as generic technology areas common to CANDU and LWR (light water reactor. This paper presents an overview of the CANDU safety R&D which includes background, drivers, current status, challenges, and future directions. This overview of the Canadian nuclear safety R&D programs includes those currently conducted by the COG (CANDU Owners Group, AECL (Atomic Energy of Canada Limited, Candu Energy Inc., and the CNSC (Canadian Nuclear Safety Commission and by universities via UNENE (University Network of Excellence in Nuclear Engineering sponsorship. In particular, the nuclear safety R&D program related to the emerging CANDU ageing issues is discussed. The paper concludes by identifying directions for the future nuclear safety R&D.

40 CFR 63.5755 - How do I demonstrate compliance with the aluminum recreational boat surface coating spray gun...

Science.gov (United States)

2010-07-01

... the aluminum recreational boat surface coating spray gun cleaning work practice standards? 63.5755... surface coating spray gun cleaning work practice standards? You must demonstrate compliance with the aluminum coating spray gun cleaning work practice standards by meeting the requirements of paragraph (a) or...

Trade, Foreign Direct Investment and R&D Spillovers

Directory of Open Access Journals (Sweden)

Jaehwa Lee

2004-06-01

Full Text Available The paper examines the evidence of R & D spillovers through trade and foreign direct investment at the industrial sectoral level. Specifically, it focuses on the appropriate measure of foreign R&D stocks embodied in imports, and proposes an alternative measure to the traditional measure. With a new measure of foreign technology, this paper then empirically distinguishes between R&D spillovers from import volume and from import variety. Panel estimations with fixed effects use a data set comprised of eight sectors in the manufacturing industry of thirteen OECD countries from 1981 to 1999. This empirical work at disaggregated level has shown the evidence to generally support the role of manufacturing imports in the international diffusion of technology. In particular, the results imply that the impact of import variety proves stronger and more significant in investigating trade-related R&D spillovers. The evidence indicates the variety effect dominates the volume effect, and hence import variety proves more important in explaining trade-related technological diffusion. This paper also investigates R&D spillovers occurring simultaneously through trade and non-trade (i.e., FDI channels, Empirical results provide no strong evidence on R&D spillovers through FDI, although FDI is often considered as an important channel for technological diffusion. The evidence implies that the effect of trade channel dominates that of the FDI channel and finds that FDI only weakly affects domestic productivity.

Risk taking and effective R&D management.

Science.gov (United States)

Banholzer, William F; Vosejpka, Laura J

2011-01-01

Several key strategies can be used to manage the risk associated with innovation to create maximum value. These include balancing the timing of investments versus cash flows, management of fads, prioritization across the company, savvy portfolio management, and a system of metrics that measure real success. Successful R&D managers will do whatever is necessary to manage the risks associated with an R&D program and stick to their long-term strategy.

Financial Development, Econmic Growth and R&D Cyclical Movement

OpenAIRE

Fung, Ka Wai Terence; Lau, Chi Keung Marco

2013-01-01

This paper builds up an endogenous growth model à la Aghion and Howitt (1992) and Boucekkine et al (2005). We assume that R&D firms use only investment good as input, instead of final good as hypothesized in the above two models. We show that investment price will be a negative function of aggregate quality index; and thus decline over time. In this model, subsidy on R&D has growth-enhancing effect. Moreover, this model predicts unambiguously that R&D is procyclical.

Measuring the Returns to R&D: The Depreciation Problem

OpenAIRE

Bronwyn H. Hall

2007-01-01

Measuring the private returns to R&D requires knowledge of its private depreciation or obsolescence rate, which is inherently variable and responds to competitive pressure. Nevertheless, most of the previous literature has used a constant depreciation rate to construct R&D capital stocks and measure the returns to R&D, a rate usually equal to 15 per cent. In this paper I review the implications of this assumption for the measurement of returns using two different methodologies: one based on t...

R&D, patents and innovation: a differential game approach

OpenAIRE

Wang, H.-M.

2016-01-01

A patent race is a technological competition among firms and the firm making a first-hand innovation takes advantages of patenting. Firms strategically invest in R&D and produce knowledge in order to innovate. Instead of growing model of R&D, I use a differential game approach to investigate firms interaction of R&D behavior in a patent race. In general, knowledge is an intangible good that gives a special feature of a patent race. Whether knowledge is substitutable to the existing knowledge ...

Demonstration Analysis of Relationship Between R&D Investment and GDP

Institute of Scientific and Technical Information of China (English)

HAN Bo-tang; LIU Bai-shan; CHEN Keng

2005-01-01

To reveal the quantitative relationship between research and development (R&D) investment and gross domestic product (GDP) in China, we have demonstrated and analyzed the relationship between R&D investment and science and technology (S&T) progress, and based on a mount of S&T statistical data, have proceeded demonstration research of the relationship between R&D investment and GDP in China with Solow and vector auto regression (VAR) models. Cubic curve fitting and cross-correlation analysis of them with SPSS have shown that there is a strong synchronic relationship between R&D investment and GDP.

German Society for Immunology and Australasian Society for Immunology joint Workshop 3(rd) -4(th) December 2015 - Meeting report.

Science.gov (United States)

Kurts, Christian; Gottschalk, Catherine; Bedoui, Sammy; Heinzel, Susanne; Godfrey, Dale; Enders, Anselm

2016-02-01

The German Society for Immunology (DGfI) and the Australasian Society for Immunology (ASI) hosted the first DGfI-ASI joint workshop from December 3-4, 2015 in Canberra, Australia. A delegation of 15 distinguished German immunologists discussed the workshop topic "immune regulation in infections and immune mediated diseases" with the aim to establish new German-Australasian collaborations, discuss new concepts in the field of immune regulation and build a scientific network to create more utilizable resources for excellent (trans-border) immunological research. The workshop was associated with the 45(th) Annual Scientific Meeting of the ASI held from Nov 29-Dec 3, 2015, opening up even more opportunities for finding new collaboration partners. A return meeting will be linked to the annual DGfI meeting that will take place in 2017 in Erlangen. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Oplevelsernes Herregård

DEFF Research Database (Denmark)

Frausing, Mikael

2010-01-01

Rundvisninger i 'den kunsthistoriske herregård' blev allerede tidligt i det 20. århundrede den foretrukne besøgsform for gæster og turister til landets herregårde, men ved indgangen til det 21. århundrede begyndte oplevelsesøkonomi og nye publikumsaktiviteter en ny udvikling med andre implikationer...

Proceedings of the specialists' meeting on accelerator-based transmutation

International Nuclear Information System (INIS)

Wenger, H.U.

1992-09-01

The meeting was organised under the auspices of OECD Nuclear Agency's International Information Exchange Programme on Actinide and Fission Product Partitioning and Transmutation. In the original announcement for the meeting the following sessions were proposed: 1) Concepts of accelerator-based transmutation systems, 2) Nuclear design problems of accelerator-based transmutation systems with emphasis on target facilities and their interfaces with accelerators, 3) Data and methods for nuclear design of accelerator-based transmutation systems, 4) Related cross-section measurements and integral experiments, 5) Identification of discrepancies and gaps and discussion of desirable R+D and benchmark activities. Due to the large number of papers submitted it was necessary to split session 2 into two parts and to reassign some papers in order to balance the sessions more evenly. No papers were submitted for session 5 and this was replaced by a summary and general discussion session. These proceedings contain all 30 papers in the order they were presented at the meeting. They are copies of the duplication-ready versions given to us during or shortly after the meeting. In the Table of Contents, the papers are listed together with the name of the presenter. (author) figs., tabs., refs

Proceedings of the 16. 2015 energy meetings

International Nuclear Information System (INIS)

2015-01-01

The energy meetings is the biggest annual event for French local communities in the energy domain. These meetings brought together more than 2000 participants during 3 days. The public is mainly composed of officials, representatives from local communities, institutions, private organisations and associations. The scope has been broaden to encompass all strategic domains dealing with energy and climate issues. This 16. edition put the question of the territorial governance by positioning the actors and their practices in the centre of the game and in a situation where they can overcome the limits imposed by the traditional public intervening forces. It demonstrates the catalytic role that local communities can play to make the energy transition a societal transition. The meetings were organised in 64 workshops and forums. These proceedings brings together the available material: 47 presentations (slides) given at 24 workshops described separately in fact sheets, plus 63 fact sheets for the description of forums content

Diagnosing the decline in pharmaceutical R&D efficiency.

Science.gov (United States)

Scannell, Jack W; Blanckley, Alex; Boldon, Helen; Warrington, Brian

2012-03-01

The past 60 years have seen huge advances in many of the scientific, technological and managerial factors that should tend to raise the efficiency of commercial drug research and development (RD). Yet the number of new drugs approved per billion US dollars spent on RD has halved roughly every 9 years since 1950, falling around 80-fold in inflation-adjusted terms. There have been many proposed solutions to the problem of declining RD efficiency. However, their apparent lack of impact so far and the contrast between improving inputs and declining output in terms of the number of new drugs make it sensible to ask whether the underlying problems have been correctly diagnosed. Here, we discuss four factors that we consider to be primary causes, which we call the 'better than the Beatles' problem; the 'cautious regulator' problem; the 'throw money at it' tendency; and the 'basic research-brute force' bias. Our aim is to provoke a more systematic analysis of the causes of the decline in RD efficiency.

Recent IAEA Achievements in the Field of Fast Neutron Systems and Scope and Objectives of the Meeting

International Nuclear Information System (INIS)

Monti, S.

2013-01-01

Scope of this technical meeting: • Within FR development programmes, significant research and development (R&D) efforts are devoted to the design of innovative reactor cores ⇒ intrinsic safety features (enhanced negative reactivity feedbacks, reduced coolant void reactivity effects, etc.), ⇒ high performance (in terms of cycle length, high fuel burnup, breeding gain, etc.), ⇒ Minor Actinide transmutation capability. • The development of high performance in-core structural materials represents one of the most challenging aspects ⇒ high neutron flux, ⇒ liquid metal coolant, ⇒ high temperatures. Objectives and expected outcomes: • Present and discuss results of studies and on-going R&D and design activities in the field of innovative reactor core concepts; • Present and discuss results of studies and on-going R&D activities in the field of advanced reactor core structural materials; • Identification of research and technology gaps to be covered through new R&D initiatives to be carried out under the aegis of the IAEA

76 FR 37371 - Ocean Energy Safety Advisory Committee; Notice of Meeting

Science.gov (United States)

2011-06-27

... Advisory Committee will meet at the Astor Crowne Plaza Hotel in New Orleans, Louisiana. DATES: Wednesday...: The Astor Crowne Plaza Hotel, 739 Canal Street, New Orleans, Louisiana 70130, telephone (504) 962-0500... Budget's Circular No. A-63, Revised. Dated: June 22, 2011. Michael R. Bromwich, Director, Bureau of Ocean...

PEFC R&D technology at Toyota

Energy Technology Data Exchange (ETDEWEB)

Kawatsu, Shigeyuki; Aoyama, Satoshi; Iwase, Masayoshi [Toyota Motor Corp., Shizuoka (Japan)

1996-12-31

Fuel cells are being considered as notable new energy sources due to, not only their potential for obtaining high energy conversion efficiencies, but also their environmental sensitive features. These are especially important now that the problems relating to global environmental pollution are regarded as serious social issues. Polymer electrolyte fuel cells (PEFCs) in particular are being pursued due in part to the prospect of realizing timely enhancements to several key characteristics, including size and power. Encouraged by these anticipated improvements, PEFCs are being investigated as promising power generator candidates for hybrid electric vehicles. The substantial future potential of PEFCs has been noted by TOYOTA, and has motivated extensive R&D activities toward the practical application of PEFCs to hybrid electric vehicles. These R&D efforts include, not only activities on such key areas as performance enhancement, but also extensive attention to a broad range of related concerns, such as cost reduction, reformer development, system integration, durability, reliability and so on. From these diverse tasks, this paper focuses on the issues related to ensuring adequate PEFC performance when reformed fuel is utilized. Recent outcomes of R&D conducted at TOYOTA on this topic will be described.

R&D Subsidiary Mandates of Western MNEs in China:

DEFF Research Database (Denmark)

Schulzmann, David; Slepniov, Dmitrij

2016-01-01

The number of Western MNCs established R&D centers in China has been rising from the year 2000 starting with under 200 centers to over 1300 centers by the end of 2010 (Stanley, Yang, & Ritacca, 2013). These developments followed increased Foreign Direct Investment (FDI) to China, underpinned...... in the world (Motohashi, 2012). These R&D investments to a large extent are flowing into technological parks with good supporting infrastructure in Beijing, Shanghai, Guangzhou and Shenzhen (Stanley et al., 2013; Walsh, 2007). Aside from the lucrative advantages of offshoring R&D to China, there are numerous...... was primarily focused on development and product adaptation to the local market (Lundin & Serger, 2007), rather than conducting new basic research which could be applied globally across the MNC (Bartlett & Ghoshal, 1998; Govindarajan & Trimble, 2012). Overtime, some R&D subsidiaries evolved and achieved...

Lead monitoring in Mugil cephalus (North-West Mediterranean, Italy

Directory of Open Access Journals (Sweden)

Maria Cesarina Abete

2012-02-01

Full Text Available The concentrations of Lead (Pb in muscles of flathead mullet (Mugil cephalus collected from Bocca di Magra, La Spezia (Ligurian Sea, Mediterranean Sea, Italy, were determined after microwave digestion by atomic absorption spectrometry and electrothermal atomisation (ETA-AAS. The average Pb concentration was 0.082 ppm and the levels varied in the following ranges: 0.020-0.240 ppm. None of the 63 tested samples exceeded the European regulatory limits fixed by 1881/2006/UE and 420/2011/UE. The estimated weekly intakes by humans were also evaluated for possible consumers healthy risks. Pb concentrations in fish muscles were in 59% of cases higher than Provisional Tolerable Weekly Intake (PTWI set by JECFA (Joint FAO/WHO Expert Committee on Food Additives in 1993 and corresponding to 0.025 mg/kg body weight. In fact, in 37 out of 63 analysed samples the Pb level was higher than 0.06 mg/kg.

8. Nuclear magnetic resonance users meeting; 1. Luso-Brazilian NMR meeting. Abstracts

International Nuclear Information System (INIS)

2001-01-01

The NMR Users Meeting is held every year in Brazil and its eighth edition took place from May 7 - 11, 2001 together with the first Luso-Brazilian Meeting on Nuclear Magnetic Resonance. The extended abstracts book comprise: ten major conferences, four plenary lectures delivered by enterprise representatives (three from USA and one from Germany), six talks about the state-of-the-art of NMR methods (especially bi and tri-dimensional new techniques) and summaries of results from one hundred and twenty four research works. Among these research results which have been discussed, one hundred and sixteen were presented as congress panels/posters and eight as oral communications. The major topics of the scientific and technological research works are thus distributed: 63% in chemical sciences (mainly structural elucidation and stereochemistry of organic compounds and dynamical studies of chemical reactions), 19% in materials science (including petroleum), 8% in applied life sciences (agricultural and food sciences, biological sciences and medicine), 8% about theoretical aspects related to nuclear magnetic resonance and 2% regarding improvements in NMR instrumental techniques

33rd Actinide Separations Conference

Energy Technology Data Exchange (ETDEWEB)

McDonald, L M; Wilk, P A

2009-05-04

Welcome to the 33rd Actinide Separations Conference hosted this year by the Lawrence Livermore National Laboratory. This annual conference is centered on the idea of networking and communication with scientists from throughout the United States, Britain, France and Japan who have expertise in nuclear material processing. This conference forum provides an excellent opportunity for bringing together experts in the fields of chemistry, nuclear and chemical engineering, and actinide processing to present and discuss experiences, research results, testing and application of actinide separation processes. The exchange of information that will take place between you, and other subject matter experts from around the nation and across the international boundaries, is a critical tool to assist in solving both national and international problems associated with the processing of nuclear materials used for both defense and energy purposes, as well as for the safe disposition of excess nuclear material. Granlibakken is a dedicated conference facility and training campus that is set up to provide the venue that supports communication between scientists and engineers attending the 33rd Actinide Separations Conference. We believe that you will find that Granlibakken and the Lake Tahoe views provide an atmosphere that is stimulating for fruitful discussions between participants from both government and private industry. We thank the Lawrence Livermore National Laboratory and the United States Department of Energy for their support of this conference. We especially thank you, the participants and subject matter experts, for your involvement in the 33rd Actinide Separations Conference.

33rd Actinide Separations Conference

International Nuclear Information System (INIS)

McDonald, L.M.; Wilk, P.A.

2009-01-01

Welcome to the 33rd Actinide Separations Conference hosted this year by the Lawrence Livermore National Laboratory. This annual conference is centered on the idea of networking and communication with scientists from throughout the United States, Britain, France and Japan who have expertise in nuclear material processing. This conference forum provides an excellent opportunity for bringing together experts in the fields of chemistry, nuclear and chemical engineering, and actinide processing to present and discuss experiences, research results, testing and application of actinide separation processes. The exchange of information that will take place between you, and other subject matter experts from around the nation and across the international boundaries, is a critical tool to assist in solving both national and international problems associated with the processing of nuclear materials used for both defense and energy purposes, as well as for the safe disposition of excess nuclear material. Granlibakken is a dedicated conference facility and training campus that is set up to provide the venue that supports communication between scientists and engineers attending the 33rd Actinide Separations Conference. We believe that you will find that Granlibakken and the Lake Tahoe views provide an atmosphere that is stimulating for fruitful discussions between participants from both government and private industry. We thank the Lawrence Livermore National Laboratory and the United States Department of Energy for their support of this conference. We especially thank you, the participants and subject matter experts, for your involvement in the 33rd Actinide Separations Conference.

The Evolution of Boundaries in Inter-organizational R&D

DEFF Research Database (Denmark)

Smith, Pernille

2011-01-01

carried out throughout an R&D project we derive three theoretical explanations to the emergence of boundaries in inter-organizational R&D: sensemaking, strategizing and culture. As these boundaries have both positive and negative impact on collaboration, recommendations for the management...

Trends & Indicators: NE Universities Still R&D Powerhouses

Science.gov (United States)

Harney, John O.

2011-01-01

New England universities performed more than $4 billion worth of research and development (R&D) in 2009, but the region's share of total R&D performed by all U.S. universities remained at 7.3%, down from more than 10% in the 1980s. The region's university research labs have been world-famous for ideas that breed companies and whole…

Visegrad Four countries: evaluation in R&D sectors of performance

Directory of Open Access Journals (Sweden)

Nina Bočková

2013-01-01

Full Text Available Competitiveness is currently being studied by many economic analyses. Generalization of the countries’ competitiveness definition as a measure of understanding of the performance evaluation economies is important. Visegrad Four countries: Hungary, the Czech Republic, Slovakia and Poland were admitted to the European Union in May 2004. EU Member States must respect the common EU objectives. The European Union, as expressed in the strategy Europe 2020, is obliged to increase competitiveness, innovation, by introduction of modern technology and especially the growth R&D investment. Limited data to evaluate R&D expenditure: inconsistencies in the R&D support, the absence of data concerning the other means of financing in the sector BERD, limitations of statistical data on the number of innovations only to firms with R&D activities. The aim of this paper is to evaluate the development of R&D expenditures by sector of funding in the Visegrad Four countries in comparison with the values of the EU-27 and countries of Visegrad Four together.

On international cost-sharing of pharmaceutical R&D.

Science.gov (United States)

Barros, Pedro Pita; Martinez-Giralt, Xavier

2008-12-01

Ramsey pricing has been proposed in the pharmaceutical industry as a principle to price discriminate among markets while allowing to recover the (fixed) R&D cost. However, such analyses neglect the presence of insurance or the fund raising costs for most of drug reimbursement. By incorporating these new elements, we aim at providing some building blocks towards an economic theory incorporating Ramsey pricing and insurance coverage. We show how coinsurance affects the optimal prices to pay for the R&D investment. We also show that under certain conditions, there is no strategic incentive by governments to set coinsurance rates in order to shift the financial burden of R&D. This will have important implications to the application of Ramsey pricing principles to pharmaceutical products across countries.

Pharmaceutical regulation in Europe and its impact on corporate R&D.

Science.gov (United States)

Eger, Stephan; Mahlich, Jörg C

2014-12-01

Many European countries regulate the markets for prescription drugs in order to cope with rising health expenditures. On the other hand, regulation distorts incentives to invest in pharmaceutical R&D. This study aims at empirically assessing the impact of regulation on pharmaceutical R&D expenditures. We analyze a sample of 20 leading pharmaceutical companies between 2000 and 2008. The share of sales in Europe serves as a proxy for the degree of pharmaceutical regulation. We control for other firm specific determinants of R&D such as cash flow, company size, leverage ratio, growth rate, and Tobin's q. Our results suggest a nonlinear relationship between European sales ratio and R&D intensity. Beyond a threshold of 33% of sales generated in Europe, a higher presence in Europe is associated with lower R&D investments. The results can be interpreted as further evidence of the deteriorating effect of regulation on firm's incentives to invest in R&D.

A Real Options Perspective on R&D Portfolio Diversification

NARCIS (Netherlands)

S. van Bekkum (Sjoerd); H.P.G. Pennings (Enrico); J.T.J. Smit (Han)

2008-01-01

textabstractThis paper shows that the presence of conditional staging in R&D (Research & Development) has a critical impact on portfolio risk, and changes diversification arguments when a portfolio is constructed. When R&D projects exhibit option-like characteristics, correlation between projects

Viral and cellular requirements for the budding of Feline Endogenous Retrovirus RD-114

Directory of Open Access Journals (Sweden)

Fukuma Aiko

2011-12-01

Full Text Available Abstract Background RD-114 virus is a feline endogenous retrovirus and produced as infectious viruses in some feline cell lines. Recently, we reported the contamination of an infectious RD-114 virus in a proportion of live attenuated vaccines for dogs and cats. It is very difficult to completely knock out the RD-114 proviruses from cells, as endogenous retroviruses are usually integrated multiply into the host genome. However, it may be possible to reduce the risk of contamination of RD-114 virus by regulating the viral release from cells. Results In this study, to understand the molecular mechanism of RD-114 virus budding, we attempted to identify the viral and cellular requirements for RD-114 virus budding. Analyses of RD-114 L-domain mutants showed that the PPPY sequence in the pp15 region of Gag plays a critical role in RD-114 virus release as viral L-domain. Furthermore, we investigated the cellular factors required for RD-114 virus budding. We demonstrated that RD-114 virus release was inhibited by overexpression of dominant negative mutants of Vps4A, Vps4B, and WWP2. Conclusions These results strongly suggest that RD-114 budding utilizes the cellular multivesicular body sorting pathway similar to many other retroviruses.

XVIIIth annual meeting of the Spanish Nuclear Society, Puerto de Santa Maria 28,29,30 October 1992 Program and abstracts

International Nuclear Information System (INIS)

1992-01-01

The presentation and the abstracts of each session in XVIIIth. Annual meeting of the Spanish Nuclear Society are contained. The principal sessions are: - Environmental aspects of Nuclear Energy - R+D in Nuclear Fusion - Materials - Radiation protection - Severe Accidents

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1)

OpenAIRE

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz; Lund, Pia; Nørby, Karin Kristiane

2013-01-01

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present opinion concerns a group of 26 sulphur-containing heterocyclic compounds evaluated by the JECFA at the 59th m...

Safety evaluation of food flavorings

International Nuclear Information System (INIS)

Schrankel, Kenneth R.

2004-01-01

Food flavorings are an essential element in foods. Flavorings are a unique class of food ingredients and excluded from the legislative definition of a food additive because they are regulated by flavor legislation and not food additive legislation. Flavoring ingredients naturally present in foods, have simple chemical structures, low toxicity, and are used in very low levels in foods and beverages resulting in very low levels of human exposure or consumption. Today, the overwhelming regulatory trend is a positive list of flavoring substances, e.g. substances not listed are prohibited. Flavoring substances are added to the list following a safety evaluation based on the conditions of intended use by qualified experts. The basic principles for assessing the safety of flavoring ingredients will be discussed with emphasis on the safety evaluation of flavoring ingredients by the Food and Agriculture Organization (FAO) and World Health Organization (WHO) Joint Expert Committee on Food Additives (JECFA) and the US Flavor and Extract Manufacturers Expert Panel (FEXPAN). The main components of the JECFA evaluation process include chemical structure, human intake (exposure), metabolism to innocuous or harmless substances, and toxicity concerns consistent with JECFA principles. The Flavor and Extract Manufacturers Association (FEMA) evaluation is very similar to the JECFA procedure. Both the JECFA and FEMA evaluation procedures are widely recognized and the results are accepted by many countries. This implies that there is no need for developing countries to conduct their own toxicological assessment of flavoring ingredients unless it is an unique ingredient in one country, but it is helpful to survey intake or exposure assessment. The global safety program established by the International Organization of Flavor Industry (IOFI) resulting in one worldwide open positive list of flavoring substances will be reviewed

Petri Net-Based R&D Process Modeling and Optimization for Composite Materials

Directory of Open Access Journals (Sweden)

Xiaomei Hu

2013-01-01

Full Text Available Considering the current R&D process for new composite materials involves some complex details, such as formula design, specimen/sample production, materials/sample test, assessment, materials/sample feedback from customers, and mass production, the workflow model of Petri net-based R&D process for new composite materials’ is proposed. By analyzing the time property of the whole Petri net, the optimized model for new composite materials R&D workflow is further proposed. By analyzing the experiment data and application in some materials R&D enterprise, it is demonstrated that the workflow optimization model shortens the period of R&D on new materials for 15%, definitely improving the R&D efficiency. This indicates the feasibility and availability of the model.

Managing R&D Alliance Portfolios

DEFF Research Database (Denmark)

Engel Nielsen, Lars; Mahnke, Volker

2003-01-01

be observed in several companies engaged in the cross section of telecommunication and mobile technology where increased complexity magnifies managerial challenges. Drawing on modern portfolio theory, this paper offers a model for managing portfolios of R&D alliances. In particular, an analysis...

Proceedings of the 3rd seminar of R and D on advanced ORIENT (International)

International Nuclear Information System (INIS)

Sasaki, Yuji; Ozawa, Masaki

2010-03-01

The 3rd Seminar of R and D on advanced ORIENT (International) was held at Tohoku University, on October 30th, 2009 organized by Japan Atomic Energy Agency. The first meeting of this seminar was held at Oarai, Ibaraki on May, 2007, and the second seminar was held at Tokai, Ibaraki on November, 2008. This seminar has the world-wide concept and includes the main topics from foreign researchers. Spent nuclear fuel should be recognized not only mass of radioactive elements but also potentially useful materials including platinum metals and rare earth elements. Taking the cooperation with universities related companies and research institutes, into consideration, we aimed at expanding and progressing the basic researches. This report records abstracts and figures submitted from the oral speakers in this seminar. (author)

A case study of R&D internationalisation in Brazil

Directory of Open Access Journals (Sweden)

Dusan Schreiber

2015-05-01

Full Text Available The decision-making process that results in installing R&D activities outside of an organisation (whether nationally or abroad involves a number of variables that deserve a more detailed analysis of their specificities. This need stems from the importance that R&D activities have taken in recent years in the organisational universe, due to the potential constitution of competitive advantage. However, following the logic of rationality contained in the theory of transaction costs demonstrated by the dilemma "Make or Buy?", R&D activities were also included in the process of evaluating the feasibility and relevance of carrying out activities internally or externally. In many cases outsourcing has occurred across national borders. This article was created with the aim of analysing the specifics of the decision-making process of three multinationals that have outsourced their R&D activities to Brazil. It is hoped that a contribution to the debate on the advantages and benefits of outsourcing these activities will be made.

2017 Bipolar Plate Workshop Summary Report

Energy Technology Data Exchange (ETDEWEB)

Kopasz, John P. [Argonne National Lab. (ANL), Argonne, IL (United States); Benjamin, Thomas G. [Argonne National Lab. (ANL), Argonne, IL (United States); Schenck, Deanna [Argonne National Lab. (ANL), Argonne, IL (United States)

2017-08-17

The Bipolar Plate (BP) Workshop was held at USCAR1 in Southfield, Michigan on February 14, 2017 and included 63 participants from industry, government agencies, universities, and national laboratories with expertise in the relevant fields. The objective of the workshop was to identify research and development (R&D) needs, in particular early-stage R&D, for bipolar plates for polymer electrolyte membrane (PEM) fuel cells for transportation applications. The focus of the workshop was on materials, manufacturing, and design aspects of bipolar plates with the goal of meeting DOE’s 2020 bipolar plate targets. Of special interest was the cost target of ≤$3/kW for the bipolar plate.

Mapping R&D within Multinational Networks: Evidence from the Electronics Industry

Science.gov (United States)

Urze, Paula; Manatos, Maria João

Based on the final results of the R&D.COM - Local R&D COMpetencies within Global Value Chains project, this paper aims at mapping the trajectories of delocalised R&D units within a multinational’s global strategy and designing the knowledge flows within the global value chain. This analysis was performed using typologies proposed in the theoretical framework, which help us to have an overview of the network. The methodology is grounded on one extended case study that involves a local R&D unit (Portugal), a foreign R&D unit (Netherlands) and the headquarters (Norway) - developed on a multinational from the electronics industry. This case is an example of a multinational company where R&D is developed mainly in the headquarters but it is also delocalised to some subsidiaries with a certain level of autonomy.

Structures and Infrastructures of International R&D Networks: A Capability Maturity Perspective

DEFF Research Database (Denmark)

Niang, Mohamed; Wæhrens, Brian Vejrum

Purpose: This paper explores the process towards globally distributing R&D activities with an emphasis on organizational maturity. It discusses emerging configurations by asking how the structure and infrastructure of international R&D networks evolve along with the move from a strong R&D center...... to dispersed development. Design/Methodology/Approach: This is a qualitative study of the process of distributing R&D. By comparing selected firms, the researchers identify a pattern of dispersion of R&D activities in three Danish firms. Findings and Discussion: Drawing from the case studies, the researchers...... present a capability maturity model. Furthermore, understanding the interaction between new structures and infrastructures of the dispersed networks is viewed as a key requirement for developing organizational capabilities and formulating adequate strategies that leverage dispersed R&D. Organizational...

R&D investment and impact in the global construction industry

National Research Council Canada - National Science Library

Hampson, Keith

2014-01-01

"R&D Investment and Impact in the Global Construction Industry brings together contributions from leading academics in a diverse group of countries to investigate the role of research and development (R&D...

3rd International Arab Forensic Sciences & Forensic Medicine Conference, ASFSFM 2017: Conference Report

Directory of Open Access Journals (Sweden)

Abdulsallam A. Bakdash

2017-12-01

Full Text Available The Arab Society for Forensic Sciences and Forensic Medicine (ASFSFM at Naif Arab University for Security Sciences seeks to present the latest developments in all fields of forensic sciences through holding specialized scientific events and academic activities. This is also achieved through its periodic scientific peer-reviewed journal, the Arab Journal of Forensic Sciences and Forensic Medicine. It also seeks to promote scientific research in all fields of forensic science and forensic medicine, and seeks actively to contribute in holding scientific meetings in accordance with advanced scientific standards, including the 3rd International Arab Forensic Sciences & Forensic Medicine Conference. This important event was attended by scientists and experts from various fields of criminal and forensic sciences from both Arab and non-Arab countries. This conference was a significant scientific accomplishment that contributed to the advancement of forensic sciences and forensic medicine in the Arab world. The conference aimed, in accordance with the vision of Naif Arab University for Security Sciences, to enhance peace, security and justice in Arab societies.  Naif Arab University for Security Sciences, represented by the Arab Society for Forensic Sciences and Forensic Medicine, held the 3rd International Arab Forensic Sciences & Forensic Medicine Conference on the University's campus during the period from 21st to 23rd November 2017. The event included the participation of more than 720 experts in forensic sciences and forensic medicine from 33 countries all over the world. Experts discussed and presented the latest developments in their fields. The conference provided a creative environment for students from both local and international universities to benefit from experts and specialists, and to access the most recent research.  On behalf of His Excellency the president of Naif Arab University for Security Sciences, and the Arab Society for

R&D, patents and innovation: a differential game approach

NARCIS (Netherlands)

Wang, H.-M.

2016-01-01

A patent race is a technological competition among firms and the firm making a first-hand innovation takes advantages of patenting. Firms strategically invest in R&D and produce knowledge in order to innovate. Instead of growing model of R&D, I use a differential game approach to investigate firms

Effectiveness of public support for R&D and entrepreneurship

NARCIS (Netherlands)

Mohnen, P.

2017-01-01

The papers by Dortet-Bernadet and Sicsic and by Redor in this issue examine respectively the success of R&D financial support programs in stimulating private R&D and the success of subsidized start-ups for the unemployed in creating long-lasting firms. Both papers focus on small French firms. Both

[Testing reliability and validity of reduced substitutes for leadership scales(rd-SLS)].

Science.gov (United States)

Kim, Jeong-Hee

2005-10-01

This paper was conducted to test the reliability and validity of rd-SLS, developed by Podsakoff, et al. (1993) which measured 'substitutes for leadership'. The subjects were 345 nurses in 5 general hospitals. Cronbach's and the Guttman split-half coefficient were used to test the reliability of rd-SLS. Factor analysis, and the correlations of the rv-SLS and SLS with rd-SLS were used for convergent and discriminant validity. Cronbach's data was 0.76 and the Guttman split-half coefficient was 0.52. Twelve factors evolved by factor analysis, which explained 70.4% of the total variance. This result was similar to previous study results. However, 'Indifference toward organizational rewards'-related items were classified two factors. It was not clear t hat the rd-SLS consisted of 13 concepts(factors). The correlations of the rv-SLS and SLS with the rd-SLS were 0.93 and 0.87 respectively. The rd-SLS showed a moderate degree of validity and reliability. Thus, it is recommended to use the rd-SLS in general nursing organizations for screening for leadership substitutes. In addition, it is necessary to clarify the concept of organizational rewards. In a further study, the factor structure of the rd-SLS may be considered.

R&D Cooperation Between Firms---A Perceived Transaction Cost Perspective

OpenAIRE

Klaus Brockhoff

1992-01-01

Transaction cost is considered as an explanatory variable for the choice between markets and various organizational arrangements for performing some predefined tasks, such as engaging in private R&D. With respect to R&D cooperation between firms, we show that the perception of high transaction cost is related to certain characteristics of the firm and to the type of R&D task. We also show a relationship between the perception of transaction cost and the perceived success of the cooperation. T...

Firm R&D units and outsourcing partners: A matching story

OpenAIRE

Barge-Gil, Andrés; Conti, Annamaria

2013-01-01

We present a theory that examines the optimal match between firm R&D units and external partners for projects that involve problem solving. We have a firm selecting an external partner conditional on the learning costs of its internal R&D unit. We show that there exists a matching equilibrium with property that external partners with low learning costs for a project work with R\\&D units that also have low learning costs for the same project. Empirically, we use a dataset of ...

Big Pharma, little science? A bibliometric perspective on Big Pharma's R&D decline

NARCIS (Netherlands)

Rafols, Ismael; Hopkins, Michael M.; Hoekman, Jarno; Siepel, Josh; O'Hare, Alice; Perianes-Rodriguez, Antonio; Nightingale, Paul

There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D

Fiscal 1991 report on the brown coal liquefaction section meeting; 1991 nendo kattan ekika bukai hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-03-01

At the 1st through 5th brown coal liquefaction group meetings held for the fiscal year, reports are delivered and discussions are made about the progress of research and development. At the 1st meeting, a fiscal 1991 brown coal liquefaction research plan is introduced, and discussed. At the 2nd meeting, an interim report on the brown coal liquefaction technology development project is discussed. At the 3rd meeting (a joint meeting of the brown coal and bituminous coal liquefaction groups), an agendum entitled 'what the development of brown/bituminous coal liquefaction technologies for the 21st century should be' is reported, and discussed. At the 4th meeting, reports are made on the results of deliberation at the Industrial Technology Council, progress of the follow-up study, progress of the collection of achievements, and so forth. At the 5th meeting, the outline of the follow-up study, the collection of achievements in the pilot plant study (a project report preparation schedule and materials evaluation), the progress of pilot plant dismantling work, etc., are reported and discussed. (NEDO)

Fiscal 1991 report on the brown coal liquefaction section meeting; 1991 nendo kattan ekika bukai hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-03-01

At the 1st through 5th brown coal liquefaction group meetings held for the fiscal year, reports are delivered and discussions are made about the progress of research and development. At the 1st meeting, a fiscal 1991 brown coal liquefaction research plan is introduced, and discussed. At the 2nd meeting, an interim report on the brown coal liquefaction technology development project is discussed. At the 3rd meeting (a joint meeting of the brown coal and bituminous coal liquefaction groups), an agendum entitled 'what the development of brown/bituminous coal liquefaction technologies for the 21st century should be' is reported, and discussed. At the 4th meeting, reports are made on the results of deliberation at the Industrial Technology Council, progress of the follow-up study, progress of the collection of achievements, and so forth. At the 5th meeting, the outline of the follow-up study, the collection of achievements in the pilot plant study (a project report preparation schedule and materials evaluation), the progress of pilot plant dismantling work, etc., are reported and discussed. (NEDO)

Efficiency, R&D and ownership - some empirical evidence

DEFF Research Database (Denmark)

Dilling-Hansen, Mogens; Madsen, Erik Strøjer; Smith, Valdemar

2003-01-01

on the technical efficiency methodology using a stochastic frontier approach in order to investigate the influence of R&D activities on the technical efficiency of the firms. Using a sample of 2370 Danish firms, the analysis suggests that R&D-active firms are significantly more efficient than other firms......Investments in R&D create an immaterial capital asset, which is expected to have a positive influence on firms' efficiency and consequently on their profit. Nonetheless, the short-term effects of current investments in R&D are difficult to prove. Therefore, this paper focuses on analyses based....... The legal form of ownership also affects the efficiency significantly, whereas firms owned by large shareholders - who are expected to exert a disciplinary influence on the managers of the firm - do not seem to be more efficient than other firms. Udgivelsesdato: JAN 25...

Knowledge Sharing and R&D Investment

Science.gov (United States)

Sarkar, Abhirup

We consider an R&D race between two symmetric firms. The game consists of two stages. In the first stage, firms non-cooperatively decide upon their levels of investment in R&D which, in turn, determine the Poisson probabilities of their subsequent sucesses. In the second stage, they engage in a Nash bargaining game to share their knowledge. We show that the firms over-invest and earn lower profits if knowledge sharing is possible compared to the situation where it is not. Hence, before the first stage, if the firms are given the option of precommitting to no knowledge sharing, they will do so and be better off. The society, of course, would be better off with full knowledge sharing.

Pump and Fan Technology Characterization and R&D Assessment

Energy Technology Data Exchange (ETDEWEB)

Goetzler, William [Navigant Consulting, Burlington, MA (United States); Guernsey, Matt [Navigant Consulting, Burlington, MA (United States); Chung, Greg [Navigant Consulting, Burlington, MA (United States)

2015-10-01

This report provides the Building Technologies Office (BTO) and the research and development (R&D) community with a technical and market analysis of pumps and fans as they pertain to commercial and residential buildings as well as key conclusions regarding the R&D opportunities that can help achieve BTO’s energy savings goals.

49 CFR 1242.84 - Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93). 1242.84 Section 1242.84 Transportation Other... PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses § 1242.84 Marketing, sales, and public relations and...

VIII Brazilian Meeting on Simulational Physics (BMSP)

International Nuclear Information System (INIS)

Branco, N. S.; Figueiredo, W.; Plascak, J. A.; Santos, M.

2016-01-01

This special issue includes invited and selected articles of the VIII Brazilian Meeting on Simulational Physics (BMSP), held in Florianópolis, Santa Catarina, Brazil, from 3rd to 8th August, 2015. This is the eighth such meeting, and the second one to have contributed papers published in Journal of Physics: Conference Series (the other was the VII BMSP). The previous meetings in the BMSP series took place in the mountains of Minas Gerais, in the region of the Brazilian Pantanal, and in the shores of Paraíba. Now, for the first time, the Meeting was held in Florianópolis, with its pleasing shores, the capital of Santa Catarina state. The VIII BMSP brought together about 50 researchers from all over the world for a vibrant and productive conference. As in the previous meetings, the talks and posters highlighted recent advances in applications, algorithms, and implementation of computer simulation methods for the study of condensed matter, materials, and out of equilibrium, quantum and biologically motivated systems. We are sure that this meeting series will continue to be an important occasion for people working in simulational physics to exchange ideas and discuss the state of the art of this always expanding field. We are very glad to put together this special issue, and are most appreciative of the efforts of the editors of the Journal of Physics: Conference Series for making this publication possible. We are grateful for the outstanding work of the Florianopolis team, for the financial support of the Brazilian agencies CAPES and CNPq, and of the Federal Universities UFPB and UFSC. At last, but not least, we would like to acknowledge all of the authors for their written submissions. (paper)

Public R&D Policy Impact Evaluation:Propensity Score Matching and Structural Modeling Estimations

OpenAIRE

Ilbeigi, Alireza

2017-01-01

This dissertation is about public research and development (R&D) subsidies to support private firms doing innovative activities and quantitative impact evaluation of the policy on total factor productivity (TFP) change and additional R&D effort. Public R&D subsidization as a public R&D policy, beside different types of public interventions, has been widely used by governments to stimulate private R&D. These policies aim to fill the gap between the private and social rates of returns by encour...

INDUSTRIAL R&D INVESTMENT IN EU: RECENT TRENDS AND LESSONS FOR ROMANIA

Directory of Open Access Journals (Sweden)

Gheorghe ZAMAN

2012-06-01

Full Text Available R&D and innovation are broadly acknowledged as the main drivers of an economy's competitiveness and growth and the measures to encourage investment in research are a central part of economic policies. This paper addresses the question of R&D investment by the private sector and aims at investigating its economic effects in terms of profit and net sales increase R&D investment, industry, EUfor the top 1000 R&D industrial investors based in the EU.

Do large mergers increase or decrease the productivity of pharmaceutical R&D?

Science.gov (United States)

Ringel, Michael S; Choy, Michael K

2017-12-01

There is current uncertainty regarding the effects of mergers on pharmaceutical R&D productivity, with various mechanisms reported by which mergers could either help or harm R&D, and mixed empirical findings in prior analyses. Here, we present an analysis that is novel in several ways: we use downstream measures of R&D productivity, account for both inputs and outputs in our calculations, and use a self-controlled design. We find that recent large pharmaceutical mergers are associated with statistically significant increases in R&D productivity. These results are perhaps not surprising in light of the broader literature on R&D productivity that points to two factors as instrumental in driving higher R&D productivity (depth of scientific information, and objectivity of decision-making based on that information), both of which could be expected to increase because of a merger. Copyright © 2017 Elsevier Ltd. All rights reserved.

Meals at medical specialty society annual meetings: a preliminary assessment.

Science.gov (United States)

La Puma, John; Schiedermayer, David; Becker, Jennifer

2003-01-01

Little isd known about how meals are chosen for medical meetings. We surveyed the annual meeting planners for 20 major specialty societies. Thirteen (65%) responded; all were currently planning their next meeting. Attendance in 2000 was reported at 113,477 physicians, with 2 million planned meals and snacks. No physician was named as responsible for food choices; the meeting planner and staff were primarily responsible for deciding what food to serve, excluding exhibit halls. Twelve (92%) respondents rated "available budget" as the most important factor. "Nutritional guidelines" were rated "very important" by eight of 13 (63%). However, no specific nutritional guidelines could be identified by any planner. All respondents indicated that members would attend a meeting if "healthy" food were the only option. For 2000, 100% of respondents indicated that for each lunch and for each dinner, a dessert had been included. No annual meeting and no planned 2001 meeting excluded potato chips, snack mixes, or candies at breaks; soda pop was offered at each break. Most respondents (89%) relied on a concluding questionnaire about the meeting facilities to evaluate the food. Respondents reported no difference in charges for "special meals," including vegetarian and kosher meals. Physicians may be unaware that some food served at medical meetings may impair learning, with excessive calorie, fat, and carbohydrate consumption. Small changes can improve the quality of food and beverages selected, without increased cost, and provide choices that conform to national nutritional guidelines. Medical meetings should serve flavorful, healthful food.

Doing R&D in a closed or open mode : dynamics and impacts on productivity

NARCIS (Netherlands)

Rosa, J.; Mohnen, P.

2013-01-01

On the one hand, firms prefer to perform R&D in an open mode (letting R&D be performed extramurally or even selling their R&D services) to benefit from knowledge spillovers and complementarities between internal and external R&D. On the other hand, they may also like to perform R&D in a closed mode

Optimizing the Level of Renewable Electric R&D Expenditures Using Real Options Analysis

Energy Technology Data Exchange (ETDEWEB)

Davis, G.; Owens, B.

2003-02-01

One of the primary objectives of the United States' federal non-hydro renewable electric R&D program is to promote the development of technologies that have the potential to provide consumers with stable and secure energy supplies. In order to quantify the benefits provided by continued federal renewable electric R&D, this paper uses ''real option'' pricing techniques to estimate the value of renewable electric technologies in the face of uncertain fossil fuel prices. Within the real options analysis framework, the current value of expected future supply from renewable electric technologies, net of federal R&D expenditures, is estimated to be $30.6 billion. Of this value, 86% can be attributed to past federal R&D efforts, and 14% can be attributed to future federal R&D efforts, assuming continued federal R&D funding at $300 million/year. In addition, real options analysis shows that the value of renewable electric technologies increases as current and future R&D funding levels increase. This indicates that the current level of federal renewable electric R&D funding is sub-optimal low.

R&D Incentives for Neglected Diseases

Science.gov (United States)

Dimitri, Nicola

2012-01-01

Neglected diseases are typically characterized as those for which adequate drug treatment is lacking, and the potential return on effort in research and development (R&D), to produce new therapies, is too small for companies to invest significant resources in the field. In recent years various incentives schemes to stimulate R&D by pharmaceutical firms have been considered. Broadly speaking, these can be classified either as ‘push’ or ‘pull’ programs. Hybrid options, that include push and pull incentives, have also become increasingly popular. Supporters and critics of these various incentive schemes have argued in favor of their relative merits and limitations, although the view that no mechanism is a perfect fit for all situations appears to be widely held. For this reason, the debate on the advantages and disadvantages of different approaches has been important for policy decisions, but is dispersed in a variety of sources. With this in mind, the aim of this paper is to contribute to the understanding of the economic determinants behind R&D investments for neglected diseases by comparing the relative strength of different incentive schemes within a simple economic model, based on the assumption of profit maximizing firms. The analysis suggests that co-funded push programs are generally more efficient than pure pull programs. However, by setting appropriate intermediate goals hybrid incentive schemes could further improve efficiency. PMID:23284648

R&D incentives for neglected diseases.

Directory of Open Access Journals (Sweden)

Nicola Dimitri

Full Text Available Neglected diseases are typically characterized as those for which adequate drug treatment is lacking, and the potential return on effort in research and development (R&D, to produce new therapies, is too small for companies to invest significant resources in the field. In recent years various incentives schemes to stimulate R&D by pharmaceutical firms have been considered. Broadly speaking, these can be classified either as 'push' or 'pull' programs. Hybrid options, that include push and pull incentives, have also become increasingly popular. Supporters and critics of these various incentive schemes have argued in favor of their relative merits and limitations, although the view that no mechanism is a perfect fit for all situations appears to be widely held. For this reason, the debate on the advantages and disadvantages of different approaches has been important for policy decisions, but is dispersed in a variety of sources. With this in mind, the aim of this paper is to contribute to the understanding of the economic determinants behind R&D investments for neglected diseases by comparing the relative strength of different incentive schemes within a simple economic model, based on the assumption of profit maximizing firms. The analysis suggests that co-funded push programs are generally more efficient than pure pull programs. However, by setting appropriate intermediate goals hybrid incentive schemes could further improve efficiency.

R&D incentives for neglected diseases.

Science.gov (United States)

Dimitri, Nicola

2012-01-01

Neglected diseases are typically characterized as those for which adequate drug treatment is lacking, and the potential return on effort in research and development (R&D), to produce new therapies, is too small for companies to invest significant resources in the field. In recent years various incentives schemes to stimulate R&D by pharmaceutical firms have been considered. Broadly speaking, these can be classified either as 'push' or 'pull' programs. Hybrid options, that include push and pull incentives, have also become increasingly popular. Supporters and critics of these various incentive schemes have argued in favor of their relative merits and limitations, although the view that no mechanism is a perfect fit for all situations appears to be widely held. For this reason, the debate on the advantages and disadvantages of different approaches has been important for policy decisions, but is dispersed in a variety of sources. With this in mind, the aim of this paper is to contribute to the understanding of the economic determinants behind R&D investments for neglected diseases by comparing the relative strength of different incentive schemes within a simple economic model, based on the assumption of profit maximizing firms. The analysis suggests that co-funded push programs are generally more efficient than pure pull programs. However, by setting appropriate intermediate goals hybrid incentive schemes could further improve efficiency.

A Methodology for Collective Evaluation and Selection of Industrial R&D Projects

OpenAIRE

Muhittin Oral; Ossama Kettani; Pascal Lang

1991-01-01

This paper proposes a methodology for evaluating and selecting R&D projects in a collective decision setting, especially useful at sectorial and national levels. It consists of two major phases: Evaluation and Selection. The evaluation process repeatedly uses mathematical programming models to determine the "relative values" of a given R&D project from the viewpoint of the other R&D projects. The selection process of R&D projects is based on these "relative values" and is done through a model...

Faculty Employment and R&D Expenditures at Research Universities

Science.gov (United States)

Zhang, Liang; Ehrenberg, Ronald G.

2010-01-01

This study uses panel data to examine the relationship between faculty employment and external R&D expenditures at Research and Doctoral institutions over a 15-year period of time. On average, a 1% increase in the number of full-time faculty is associated with about 0.2% increase in total R&D expenditure. Further, a one percentage point increase…

Hooked on Coal: Meeting Energy Demands in the Philippines

Science.gov (United States)

2011-10-27

overview/seeking-balance-while-electricity-supply- surges-meet-demand-companies-struggle-find-domestic 10 Lenie Lectura , “Long, Uphill Climb Before...Yet, Says Scientist,” 2 February 2009, accessed 6 October 2017, Proquest. 59 Lenie Lectura , “DOE Chief Favors Nuclear-Power Generation for PHL...139, accessed 6 October 2017, Proquest. 63 Lenie Lectura , “DOE Chief Favors Nuclear-Power Generation for PHL,” Business Mirror, 30 August 2016

Wind tunnel tests of the NACA 63-415 and a modified NACA 63-415 airfoil

DEFF Research Database (Denmark)

Bak, C.; Fuglsang, P.; Johansen, J.

2000-01-01

This report contains 2D measurements of the NACA 63-415 and a NACA 63-415 airfoil with modified leading edge called NACA 63-415-Risø-D. The aerodynamic properties were derived from pressure measurements on the airfoil surface and in the wake. The VELUXopen jet wind tunnel was used having a backgr......This report contains 2D measurements of the NACA 63-415 and a NACA 63-415 airfoil with modified leading edge called NACA 63-415-Risø-D. The aerodynamic properties were derived from pressure measurements on the airfoil surface and in the wake. The VELUXopen jet wind tunnel was used having...... a background turbulence intensity of 1%, an inlet flow velocity of 40 m/s which resulted in a Reynolds number of 1.6×106. The airfoil sections had a chord of 0.600 m and 0.606 m for NACA 63-415 and NACA 63-415-Risø-D,respectively. The span was 1.9 m and end plates were used to minimise 3D flow effects...

Effective Control Rights in Vertical R&D Collaboration

DEFF Research Database (Denmark)

Kloyer, Martin

2011-01-01

by allocating the so-called control rights to the supplier. These rights primarily regulate the assignment of the intellectual property rights, the control of the R&D process, and the marketing of the final products that are based on the delivered R&D results. To date, we do not have any empirical evidence......Because of increasing technological complexity of new products, the manufacturers of final products more often seek access to external sources of knowledge at the early, market-distant stages of innovation processes. However, they are confronted with a specifically high danger of moral hazard....... Traditional management instruments fail to control that danger mainly for two reasons. First, the supplier activities are not transparent. Second, market-distant R&D results are credence goods whose quality cannot be evaluated, not even ex post. It is the theory of incomplete contracts that solves the problem...

High field accelerator magnet R&D in Europe

CERN Document Server

Devred, Arnaud; Bottura, L; Chorowski, M; Fabbricatore, P; Leroy, D; den Ouden, A; Rifflet, J M; Rossi, L; Vincent-Viry, O; Volpini, G

2004-01-01

The LHC magnet R&D program has shown that the limit of NbTi technology at 1.9 K was in the 10-to-10.5-T range. Hence, to go beyond the 10-T threshold, it is necessary to change the superconducting material. Given the state of the art in HTS, the only serious candidate is Nb$_{3}$Sn. A series of dipole magnet models built at Twente University and LBNL as well as a vigorous program carried out at Fermilab have demonstrated the feasibility of Nb$_{3}$Sn magnet technology. The next step is to bring this technology to maturity, which require further conductor and conductor insulation development and a simplification of manufacturing processes. After a brief history, we review ongoing R&D programs in Europe and we present the Next European Dipole (NED) initiative promoted by the European Steering Group on Accelerator R&D (ESGARD).

Overview of the NASA balloon R&D program

Science.gov (United States)

Smith, I. Steve, Jr.

1994-01-01

The catastrophic balloon failure during the first half of the 1980's identified the need for a comprehensive and continuing balloon research and development (R&D) commitment by NASA. Technical understanding was lacking in many of the disciplines and processes associated with scientific ballooning. A comprehensive balloon R&D plan was developed in 1986 and implemented in 1987. The objectives were to develop the understanding of balloon system performance, limitations, and failure mechanisms. The program consisted of five major technical areas: structures, performance and analysis, materials, chemistry and processing, and quality control. Research activitites have been conducted at NASA/Goddard Space Flight Center (GSFC)-Wallops Flight Facility (WFF), other NASA centers and government facilities, universities, and the balloon manufacturers. Several new and increased capabilities and resources have resulted from this activity. The findings, capabilities, and plan of the balloon R&D program are presented.

Globalization of R&D: Leveraging Offshoring for Innovative Capability and Organizational Flexibility

NARCIS (Netherlands)

D. Moitra (Deependra)

2008-01-01

textabstractWithin the realm of globalization of R&D, offshoring is a relatively recent and still emerging phenomenon. Rooted in the notion of comparative advantage, offshoring of R&D involves disaggregation and global distribution of the firm’s R&D value chain activities to leverage innovation

Leveraging R&D Resources via the Joint LLC Model

Science.gov (United States)

Ganz, Matthew W.

2008-03-01

Industrial scientific research labs have become increasingly stressed in recent years by a variety of external forces. Both corporations and government funding agencies have shifted their priorities from long-term fundamental research toward projects that have a high probability of shorter-term payoff. Industrial funding has been further stressed by an increasing demand for quarterly results and fierce global competition. Industry leaders are now asking their R&D labs for ``home runs” and not just a solid base in the physical sciences. The end of the Cold War has also left the US without a declared enemy whose overt intention was to defeat us through a mastery of large-scale weaponry based upon exploitation of fundamental physics. This, when combined with a bona-fide need for technology gap fillers to respond to on-the-ground threats in the current Middle East conflicts, has led to diminished government emphasis on long-term research in the physical sciences. Simultaneously, the global sources of R&D spending are expanding. The dramatic growth of private equity in the technology development arena has both drawn talent from industry and changed the expectations on researchers. R&D spending in China, India and many other countries is growing significantly. Thus, in order to become relevant, industry must now keep its finger on the pulse of the hundreds of billions of dollars being invested privately and publicly around the world. HRL Laboratories, LLC in Malibu, California represents a unique and successful new business model for industrial R&D. HRL was founded by Howard Hughes in 1948 as the Hughes Research Laboratory and for more than four decades was the internal R&D lab for the Hughes Aircraft Company. After a series of mergers, acquisitions and divestitures over the past 15 years, HRL is now a stand-alone LLC that is owned jointly by General Motors and the Boeing Company. HRL, with a staff of about 300, performs R&D services for GM and Boeing as well as for

Presence of infectious RD-114 virus in a proportion of canine parvovirus isolates.

Science.gov (United States)

Yoshikawa, Rokusuke; Sato, Eiji; Miyazawa, Takayuki

2012-03-01

We recently found that certain canine live attenuated vaccines produced using `non-feline' cell lines were contaminated with an infectious feline endogenous retrovirus, termed RD-114 virus. We suspected that RD-114 virus may have contaminated the seed stock of canine parvovirus (CPV) during the production of the contaminated vaccines. In this study, we collected stock viruses of CPVs propagated in a feline cell line, and checked the presence of infectious RD-114 virus. Consequently, we found that RD-114 viral RNA was present in all stock viruses, and 7 out of 18 stock viruses were contaminated with infectious RD-114 virus. We also found that RD-114 virus was stable physically and is capable of retaining its infectivity for a long period at -80°C.

Astrocyte morphology after cortical stab wound revealed by single-cell confocal 3D morphometry

Czech Academy of Sciences Publication Activity Database

Chvátal, Alexandr; Anděrová, Miroslava; Petřík, David; Syková, Eva

č. 2 (2003), s. 63 ISSN 0894-1491. [European Meeting on Glia l Cell Function in Health and Disease /6./. Berlín, 03.09.2003-06.09.2003] R&D Projects: GA ČR GA305/02/1528; GA MŠk LN00A065 Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111300004 Keywords : cortical stab wound * morphometry Subject RIV: FH - Neurology Impact factor: 4.677, year: 2003

40 CFR 63.7824 - What test methods and other procedures must I use to establish and demonstrate initial compliance...

Science.gov (United States)

2010-07-01

... settings established in your capture system operation and maintenance plan. (b) For a venturi scrubber subject to operating limits for pressure drop and scrubber water flow rate in § 63.7790(b)(2), you must.... (c) You may change the operating limits for a capture system or venturi scrubber if you meet the...

Factors for analysing and improving performance of R&D in Malaysian universities

NARCIS (Netherlands)

Ramli, Mohammad Shakir; de Boer, S.J.; de Bruijn, E.J.

2004-01-01

This paper presents a model for analysing and improving performance of R&D in Malaysian universities. There are various general models for R&D analysis, but none is specific for improving the performance of R&D in Malaysian universities. This research attempts to fill a gap in the body of knowledge

Public meetings: Thank you for your interest

CERN Multimedia

Staff Association

2011-01-01

Several hundreds of you took part in our recent information meetings1. We very much appreciate these times when we get together and, by listening to your questions and comments, can have a better idea of your concerns. You were particularly interested in the changes to the rules of the health insurance. Indeed, as a complement to the information given by Philippe Charpentier at the meeting organized by HR on Friday 23rd September, we showed you how a well-functioning concertation process has enabled our mutual health insurance system to evolve by modernizing it and making it fairer, while keeping the same excellent benefits. Do not hesitate to contact your departmental delegates if you have further questions concerning the health insurance, they will do all they can to inform you. As far as our merit-based advancement scheme, MARS, is concerned, we are far from convinced that this is the best system, one that truly corresponds to the needs of CERN, an organization of scientific and technical excellence, w...

Examination of the behavior of R&D returns using a power law

NARCIS (Netherlands)

Casault, Sébastien; Groen, Arend J.; Linton, J.D.; Linton, Jonathan

2013-01-01

This paper provides an improved model, based on historical data, that describes the returns on assets that result from R&D efforts to assist managers of public and private R&D activities. Such a model may lead to better decision support tools to monetize the value that may be extracted from R&D,

Low R&D Efficiency in Large Pharmaceutical Companies

DEFF Research Database (Denmark)

Madsen, Erik Strøjer; Wu, Yanqing

2016-01-01

Large pharmaceutical companies will face serious challenges in the future when several of their blockbuster drugs run out of patents, and meanwhile a growing political pressure to stop the fast increase in health care expenditures has merged. The recent wave of mergers and acquisitions (M&A) within...... the industry can be seen as an effective means to reduce costs and compensate for the reduced earnings from patented drugs. The paper examines the main development in expenditure on research and development (R&D) and number of patents in the industry with a focus on the role of company size. The analysis...... builds on a data set containing information of both patents and R&D expenditure from the world’s top 90 largest pharmaceutical companies, as well as their account data from 2002 to 2013. The empirical part estimates the firm size effect on R&D efficiency and the amount of investment allocated to R...

The Merger Paradox and R&D

OpenAIRE

MIYAGIWA, Kaz; WAN, Jiangyun(Yunyun)

2015-01-01

The merger paradox is revisited in the presence of cost-reducing R&D in Cournot oligopoly. Two cases are found, in which merger is profitable without satisfying the 80-percent threshold requirement of Salant et al (1983).

What are the determinants of investment in environmental R&D?

International Nuclear Information System (INIS)

Costa-Campi, M.T.; García-Quevedo, J.; Martínez-Ros, E.

2017-01-01

To face the challenges posed by climate change, environmental R&D and innovation are critical factors if we hope to cut emissions; yet, investment in environmental R&D remains below the social optimum. The aim of this paper is to analyse the determinants of investment in environmental innovation and to detect the differences, if any, with the determinants of investment in general innovation. In addition, this paper examines the relationship between environmental innovation R&D expenditure and a range of policy instruments, including environmental regulation and other policy measures including R&D subsidies and environmental taxes. The empirical analysis is carried out for 22 manufacturing sectors in Spain for the period 2008–2013. To overcome problems of data availability, we construct a comprehensive database from different surveys. The main implications from our results are (1). Managerial strategy appears as a relevant driver of environmental R&D investments. (2) The establishment of a policy mix between environmental, energy and technological regulatory measures is recommended. (3) The promotion of self-regulation through actions that encourage companies to follow a policy that affects their energy efficiency and is environmentally friendly. - Highlights: • Analysis of the environmental innovation investment. • Link between environmental innovation and policy instruments. • Use of a policy mix instruments enhances environmental innovation.

Boliglokalisering og transportadfærd

DEFF Research Database (Denmark)

Hartoft-Nielsen, Peter

nye boligbebyggelser i udvalgte byregioner: hovedstadsområdet, Århusområdet samt fire mellemstore provinsbyer: Kolding, Vejle, Herning og Holstebro. Undersøgelsen bygger på 5.495 interviews i 51 nyere boligbebyggelser opført inden for de seneste 10 år. Transportadfærd belyses for al nærtransport i...

R&D activities on RF contacts for the ITER ion cyclotron resonance heating launcher

Energy Technology Data Exchange (ETDEWEB)

Hillairet, Julien, E-mail: julien.hillairet@cea.fr [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Argouarch, Arnaud [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Bamber, Rob [CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Beaumont, Bertrand [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Bernard, Jean-Michel; Delaplanche, Jean-Marc [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Durodié, Frédéric [Laboratory for Plasmas Physics, 1000 Brussels (Belgium); Lamalle, Philippe [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Lombard, Gilles [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Nicholls, Keith; Shannon, Mark [CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Vulliez, Karl [Maestral Laboratory, Technetics Group, Pierrelatte (France); Cantone, Vincent; Hatchressian, Jean-Claude; Larroque, Sébastien; Lebourg, Philippe; Martinez, André; Mollard, Patrick; Mouyon, David; Pagano, Marco [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); and others

2015-10-15

Highlights: • CEA have developed a dedicated test-bed for testing RF contact in ITER relevant conditions (vacuum, temperature, RF current). • A prototype of RF contacts have been designed and manufactured, with copper lamellas brazed on a titanium holder. • This RF contact prototype failed at RF current larger than 1.8 kA. • Extensive R&D is foreseen with new RF contact designs. - Abstract: Embedded RF contacts are integrated within the ITER ICRH launcher to allow assembling, sliding and to lower the thermo-mechanical stress. They have to withstand a peak RF current up to 2.5 kA at 55 MHz in steady-state conditions, in the vacuum environment of the machine. The contacts have to sustain a temperature up to 250 °C during several days in baking operations and have to be reliable during the whole life of the launcher without degradation. The RF contacts are critical components for the launcher performance and intensive R&D is therefore required, since no RF contacts have so far been qualified at these specifications. In order to test and validate the anticipated RF contacts in operational conditions, CEA has prepared a test platform consisting of a steady-state vacuum pumped RF resonator. In collaboration with ITER Organization and the CYCLE consortium (CYclotron CLuster for Europe), an R&D program has been conducted to develop RF contacts that meet the ITER ICRH launcher specifications. A design proposed by CYCLE consortium, using brazed lamellas supported by a spring to improve thermal exchange efficiency while guaranteeing high contact force, was tested successfully in the T-resonator up to 1.7 kA during 1200 s, but failed for larger current values due to a degradation of the contacts. Details concerning the manufacturing of the brazed contacts on its titanium holder, the RF tests results performed on the resonator and the non-destructive tests analysis of the contacts are given in this paper.

Radioactive 63Ni in biological research

International Nuclear Information System (INIS)

Kasprzak, K.S.; Sunderman, F.W. Jr.

1979-01-01

Applications of 63 Ni in biological research are reviewed, with emphasis upon recent investigations of nickel metabolism and toxicology in experimental animals. The radiochemistry of 63 Ni is summarized, including consideration of the preparation of certain 63 Ni compounds (e.g. 63 Ni(CO) 4 and 63 Ni 3 S 2 ) that are of current interest in toxicology, teratology and cancer research. Practical guidance is given regarding the detection and determination of 63 Ni in biological materials by autoradiography and liquid scintillation spectrometry. (author)

Renewable energy: RD&D priorities. Insights from IEA technology programmes

Energy Technology Data Exchange (ETDEWEB)

none

2006-12-19

In order to substantially enhance the share of renewable energy technologies in the energy portfolio, it is imperative to accelerate technological advancement and subsequently reduce costs, in combination with novel applications and deployment. This outcome can be significantly supported by a range of RD and D initiatives, if properly designed and implemented. This publication reviews the current status of the renewable energy technologies portfolio and provides guidance on their mid- and long-term development. The study explores the options for the RD&D to achieve breakthroughs that will lead to large-scale markets and identifies what activities should take priority. It also looks at the benefits of increased RD&D funding in terms of technological advancement and cost improvement. It covers renewable energy technologies in the early research stage through to those that have reached a level of maturity. It also lists national renewable energy RD and D trends in IEA member countries.

The case for entrepreneurship in R&D in the pharmaceutical industry.

Science.gov (United States)

Douglas, Frank L; Narayanan, V K; Mitchell, Lesa; Litan, Robert E

2010-09-01

A lack of entrepreneurial behaviour has often been highlighted as a contributor to the decline in the research and development (R&D) productivity of the pharmaceutical industry. Here, we present an assessment of entrepreneurship in the industry, based on interviews with 26 former and current leaders of R&D departments at major pharmaceutical and biotechnology companies. Factors are highlighted that could be important in promoting entrepreneurial behaviour, which might serve as a catalyst for revitalizing R&D productivity.

Contamination of infectious RD-114 virus in vaccines produced using non-feline cell lines.

Science.gov (United States)

Yoshikawa, Rokusuke; Sato, Eiji; Miyazawa, Takayuki

2011-01-01

All domestic cats have a replication-competent endogenous retrovirus, termed RD-114 virus, in their genome and several feline cell lines produce RD-114 viruses. Recently, we found that a portion of live attenuated feline and canine vaccines produced using feline cell lines was contaminated with infectious RD-114 viruses. In this study, we expanded our survey and examined canine vaccines produced using 'non-feline' cell lines. Consequently, we found two vaccines containing RD-114 viral RNA by reverse transcriptase (RT)-polymerase chain reaction (PCR) and real-time RT-PCR. We also confirmed the presence of infectious RD-114 virus in the vaccines by the LacZ marker rescue assay and PCR to detect proviral DNA in TE671 cells (human rhabdomyosarcoma cells) inoculated with the vaccines. It is impossible to investigate the definitive cause of contamination with RD-114 virus; however, we suspect that a seed canine parvovirus type 2 was contaminated with RD-114 virus, because many canine parvoviruses have been isolated and attenuated using feline cell lines. To exclude RD-114 virus from live attenuated vaccines, we must pay attention to the contamination of seed viruses with RD-114 virus in addition to avoiding feline cell lines producing RD-114 virus when manufacturing vaccines. Copyright © 2010 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

Impressions from the 3rd Nordcode Seminar & Workshop

DEFF Research Database (Denmark)

Lenau, Torben Anker; Boelskifte, Per; Hansen, Claus Thorp

2005-01-01

This paper summarises the purpose and contents of the 3rd Nordcode Seminar and Workshop. First, the workshop assignments are described. Second, the paper briefly presents the topics of the keynote speeches and all presentations of the working papers that took place in the seminar.......This paper summarises the purpose and contents of the 3rd Nordcode Seminar and Workshop. First, the workshop assignments are described. Second, the paper briefly presents the topics of the keynote speeches and all presentations of the working papers that took place in the seminar....

MNE Subsidiaries’ Outsourcing and Insourcing of R&D

DEFF Research Database (Denmark)

Santangelo, Grazia D.; Meyer, Klaus E.; Jindra, Björn

2016-01-01

The rules for business vary not only between countries, but within countries. Subsidiaries of multinational enterprises (MNEs), thus, have to consider both the national level and the local context when designing their business practices. To examine this impact, we study R&D outsourcing in four...... Eastern member states of the European Union and find that local R&D outsourcing is used more frequently where local institutions are strong. However, this local impact depends on the MNE's overall knowledge sourcing practice and is weaker when MNE subsidiaries’ knowledge management prioritizes external...

The mismatch between the health research and development (R&D) that is needed and the R&D that is undertaken: an overview of the problem, the causes, and solutions.

Science.gov (United States)

Viergever, Roderik F

2013-10-10

One of the most pressing global health problems is that there is a mismatch between the health research and development (R&D) that is needed and that which is undertaken. The dependence of health R&D on market incentives in the for-profit private sector and the lack of coordination by public and philanthropic funders on global R&D priorities have resulted in a global health R&D landscape that neglects certain products and populations and is characterised, more generally, by a distribution that is not 'needs-driven'. This article provides an overview of the mismatch, its causes, and solutions.

3rd Sino-German Conference “Underground Storage of CO2 and Energy”

CERN Document Server

Xie, Heping; Were, Patrick

2013-01-01

Anthropogenic greenhouse gas emissions, energy security and sustainability are three of the greatest contemporary global challenges today. This year the Sino-German Cooperation Group “Underground Storage of CO2 and Energy”, is meeting on the 21-23 May 2013 for the second time in Goslar, Germany, to convene its 3rd Sino-German conference on the theme “Clean Energy Systems in the Subsurface: Production, Storage and Conversion”.   This volume is a collection of diverse quality scientific works from different perspectives elucidating on the current developments in CO2 geologic sequestration research to reduce greenhouse emissions including measures to monitor surface leakage, groundwater quality and the integrity of caprock, while ensuring a sufficient supply of clean energy. The contributions herein have been structured into 6 major thematic research themes: Integrated Energy and Environmental Utilization of Geo-reservoirs: Law, Risk Management & Monitoring CO2 for Enhanced Gas and Oil Recovery, Coa...

Sectoral Productivity Growth and R&D Spillovers in the Netherlands

NARCIS (Netherlands)

Nahuis, R.; Tang, P.J.G.

1999-01-01

This paper assesses empirically whether R&D spillovers are important and whether they originate from domestic or foreign activities. Data for eleven sectors are used to explain the impact on total factor productivity of R&D by the sector itself, by other Dutch sectors and by foreign sectors. We find

File list: Oth.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.Lar.50.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX318781,SRX31878...5306 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.50.AllAg.3rd_instar.bed ...

45 CFR 63.38 - Publications.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Publications. 63.38 Section 63.38 Public Welfare... THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Special Provisions § 63.38 Publications. Any publication or presentation resulting from or primarily related to Federal financial assistance under this...

RD & D priorities for energy production and resource conservation from municipal solid waste

Energy Technology Data Exchange (ETDEWEB)

1992-08-01

This report identifies research, development, and demonstration (RD&D) needs and priorities associated with municipal solid waste (MSW) management technologies that conserve or produce energy or resources. The changing character of MSW waste management and the public`s heightened awareness of its real and perceived benefits and costs creates opportunities for RD&D in MSW technologies. Increased recycling, for example, creates new opportunities for energy, chemicals, and materials recovery. New technologies to control and monitor emissions from MSW combustion facilities are available for further improvement or application. Furthermore, emerging waste-to-energy technologies may offer environmental, economic, and other advantages. Given these developments, DOE identified a need to assess the RD&D needs and pdodties and carefully target RD&D efforts to help solve the carbon`s waste management problem and further the National Energy Strategy. This report presents such an assessment. It identifies and Documents RD&D needs and priorities in the broad area of MSW resource . recovery, focusing on efforts to make MSW management technologies commercially viable or to improve their commercial deployment over a 5 to l0 year period. Panels of technical experts identifies 279 RD&D needs in 12 technology areas, ranking about one-fifth of these needs as priorities. A ``Peer Review Group`` identified mass-burn combustion, ``systems studies,`` landfill gas, and ash utilization and disposal as high priority areas for RD&D based on cost and the impacts of further RD&D. The results of this assessment are intended to provide guidance to DOE concerning possible future RD&D projects.

Service-oriented innovation in R&D

NARCIS (Netherlands)

Fisscher, O.A.M.; Wognum, P.M.

2002-01-01

In this article, the concept of service orientation in R&D is explored. Three forms of service-orientation are discussed integrated products, service offering, and service competence. The first form, integrated products, addresses the development of complex integrated products in which service

Enhanced Geothermal Systems (EGS) R&D Program

Energy Technology Data Exchange (ETDEWEB)

Entingh, Daniel J.

1999-08-18

The purpose of this workshop was to develop technical background facts necessary for planning continued research and development of Enhanced Geothermal Systems (EGS). EGS are geothermal reservoirs that require improvement of their permeability or fluid contents in order to achieve economic energy production. The initial focus of this R&D program is devising and testing means to extract additional economic energy from marginal volumes of hydrothermal reservoirs that are already producing commercial energy. By mid-1999, the evolution of the EGS R&D Program, begun in FY 1988 by the U.S. Department of Energy (DOE), reached the stage where considerable expertise had to be brought to bear on what technical goals should be pursued. The main purpose of this Workshop was to do that. The Workshop was sponsored by the Office of Geothermal Technologies of the Department of Energy. Its purpose and timing were endorsed by the EGS National Coordinating Committee, through which the EGS R&D Program receives guidance from members of the U.S. geothermal industry. Section 1.0 of this report documents the EGS R&D Program Review Session. There, managers and researchers described the goals and activities of the program. Recent experience with injection at The Geysers and analysis of downhole conditions at Dixie Valley highlighted this session. Section 2.0 contains a number of technical presentations that were invited or volunteered to illuminate important technical and economic facts and opportunities for research. The emphasis here was on fi.acture creation, detection, and analysis. Section 3.0 documents the initial general discussions of the participants. Important topics that emerged were: Specificity of defined projects, Optimizing cost effectiveness, Main technical areas to work on, Overlaps between EGS and Reservoir Technology R&D areas, Relationship of microseismic events to hydraulic fractures, and Defining criteria for prioritizing research thrusts. Sections 4.0 and 5.0 report

40 CFR 63.301 - Definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Definitions. 63.301 Section 63.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Oven Batteries § 63.301 Definitions. Terms used in this subpart are defined in the Act or in this...

Human coronavirus NL63, France

NARCIS (Netherlands)

Vabret, Astrid; Mourez, Thomas; Dina, Julia; van der Hoek, Lia; Gouarin, Stéphanie; Petitjean, Joëlle; Brouard, Jacques; Freymuth, François

2005-01-01

The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory

40 CFR 63.1516 - Reports.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Reports. 63.1516 Section 63.1516... Hazardous Air Pollutants for Secondary Aluminum Production Notifications, Reports, and Records § 63.1516 Reports. (a) Startup, shutdown, and malfunction plan/reports. The owner or operator must develop a written...

File list: Oth.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.Lar.10.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX104963,SRX10497...4971,SRX331403 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.10.AllAg.3rd_instar.bed ...

File list: Oth.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.Lar.20.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX318781,SRX31878...1403,SRX495243 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.20.AllAg.3rd_instar.bed ...

File list: Oth.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.Lar.05.AllAg.3rd_instar dm3 TFs and others Larvae 3rd instar SRX104964,SRX10496...1403,SRX495243 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Lar.05.AllAg.3rd_instar.bed ...

Academic R&D Spending Maintains Growth from All Major Sources in FY 2001. Info Brief.

Science.gov (United States)

Machen, M. Marge; Shackelford, Brandon

Data from the Academic Research and Development (R&D) Survey and other surveys were used to analyze patterns of R&D activity in the United States. For the purpose of this analysis, the most recent data update from the report "National Patterns of R&D Resources" adjusts university and college R&D performance to net out R&D expenditures reported as…

TIARA: Toward accelerator R&D coordination

CERN Multimedia

Anaïs Schaeffer

2011-01-01

The preparatory phase of the TIARA (Test Infrastructure and Accelerator Research Area) project has begun. In January, members from 11 research institutes in 8 European countries began a three-year collaboration intended to enhance, improve and structure R&D efforts in the area of accelerator science and technology in Europe.   Partly funded by the European Commission under its Seventh Framework Programme (FP7), the TIARA project is being coordinated by the CEA (Commissariat à l’Énergie Atomique et aux Energies Alternatives). “The aim of the project is to arrive at an organisational structure that will provide coordination for R&D efforts and associated infrastructures in the field of particle accelerators in Europe,” explains the CEA’s Céline Tanguy, project coordinator assistant. “The new structure, which we hope will be a durable one, will be set up at the end of the project’s preparatory phase....

Do spillovers justify subsidies to commercial R&D? : four microeconometric essays

OpenAIRE

Møen, Jarle

2002-01-01

Chapter 1: In the introductory chapter, I place my thesis in an empirical research tradition going back to the mid-19S0s, investigating the economics of technological change. Key issues have been the private and social returns to R&D, and the scope for technology policy in enhancing economic growth. It is widely accepted that the social returns to R&D is greater than the private returns, and that public support for R&D may be welfare improving. At the same time, a numb...

Numerical and experimental modelling of transition in a separated boundary layer on the NACA63A421 Airfiol

Czech Academy of Sciences Publication Activity Database

Ďuriš, M.; Popelka, Lukáš; Příhoda, Jaromír; Šimurda, David

2010-01-01

Roč. 56, č. 3 (2010), s. 47-53 ISSN 1210-0471. [International Meeting of Departments of Fluid Mechanics and Thermomechanics held in Rožnov pod Radhoštěm /29./. Rožnov pod Radhoštěm, 23.06.2010-25.06.2010] R&D Projects: GA MŠk(CZ) 1M06031; GA ČR GA103/09/0977 Institutional research plan: CEZ:AV0Z20760514 Keywords : boundary layer transition * CFD * airfoil Subject RIV: BK - Fluid Dynamics

Spareadfærd i krisetider

DEFF Research Database (Denmark)

Foged, Søren Kjær; Sørensen, Eva Moll

2016-01-01

Denne artikel undersøger sammenhængen mellem økonomisk pres og spareadfærd i politiske organisationer. Sammenhængen undersøges via casestudier i 6 danske kommuner, som alle oplevede en stigning i det økonomiske pres fra 2009 til 2013. Data består af 7-10 interviews i hver kommune samt tal for cas...

Corporate Governance and Its Impact on R&D Investment in Emerging Markets

DEFF Research Database (Denmark)

Rapp, Marc Steffen; A. Udoieva, Iuliia

2017-01-01

Corporate R&D activities are inherently risky but also difficult to monitor. Against this background, we examine the impact of ownership concentration and legal shareholder rights protection on corporate R&D investments in emerging markets. Based on a comprehensive sample of publicly listed firms...... shareholders to diversify their investment risks, is beneficial for corporate R&D and that this effect is intensified by more developed institutions....

10 CFR 63.141 - Scope.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 63.141 Section 63.141 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Quality Assurance § 63.141 Scope. As used in this part, quality assurance comprises all those...

40 CFR 63.361 - Definitions.

Science.gov (United States)

2010-07-01

... § 63.362 is required to be in compliance with the standard. Deviation means any instance in which an... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Definitions. 63.361 Section 63.361... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES Ethylene Oxide Emissions Standards...

Proceedings of the meeting on tunneling reaction and low temperature chemistry, 97 October. Tunneling reaction and quantum medium

Energy Technology Data Exchange (ETDEWEB)

Miyazaki, Tetsuo; Aratono, Yasuyuki; Ichikawa, Tsuneki; Shiotani, Masaru [eds.

1998-02-01

Present report is the proceedings of the 3rd Meeting on Tunneling Reaction and Low Temperature Chemistry held in Oct. 13 and 14, 1997. The main subject of the meeting is `Tunneling Reaction and Quantum Medium`. In the meeting, the physical and chemical phenomena in the liquid helium such as quantum nucleation, spectroscopy of atoms and molecules, and tunneling abstraction reaction of tritium atom were discussed as the main topics as well as the tunneling reactions in the solid hydrogen and organic compounds. Through the meetings held in 1995, 1996, and 1997, the tunneling phenomena proceeding at various temperatures (room temperature to mK) in the wide fields of chemistry, biology, and physics were discussed intensively and the importance of the tunneling phenomena in the science has been getting clear. The 12 of the presented papers are indexed individually. (J.P.N.)

Proceedings of the meeting on tunneling reaction and low temperature chemistry, 97 October. Tunneling reaction and quantum medium

International Nuclear Information System (INIS)

Miyazaki, Tetsuo; Aratono, Yasuyuki; Ichikawa, Tsuneki; Shiotani, Masaru

1998-02-01

Present report is the proceedings of the 3rd Meeting on Tunneling Reaction and Low Temperature Chemistry held in Oct. 13 and 14, 1997. The main subject of the meeting is 'Tunneling Reaction and Quantum Medium'. In the meeting, the physical and chemical phenomena in the liquid helium such as quantum nucleation, spectroscopy of atoms and molecules, and tunneling abstraction reaction of tritium atom were discussed as the main topics as well as the tunneling reactions in the solid hydrogen and organic compounds. Through the meetings held in 1995, 1996, and 1997, the tunneling phenomena proceeding at various temperatures (room temperature to mK) in the wide fields of chemistry, biology, and physics were discussed intensively and the importance of the tunneling phenomena in the science has been getting clear. The 12 of the presented papers are indexed individually. (J.P.N.)

Unique challenges lead to innovative solutions on PETROBRAS' P-63 project

Energy Technology Data Exchange (ETDEWEB)

Clark, David J; Dakin, Brian V [Amec Oil and Gas Americas, Houston, TX (United States)

2012-07-01

In early 2010, PETROBRAS accepted bids for the design, fabrication, installation and operation of the P-63 FPSO for the first three years of production starting in 2013. The field is to be produced using dry tree wells located at the adjacent P-61 tension leg platform (TLP) and subsea wells flowing to the P-63 floating production storage and offloading (FPSO) vessel. Production processing facilities are located primarily on the FPSO with multiple fluid transfer lines directing raw produced fluids from P-61 to P-63 for processing. The oil is a heavy crude with low associated gas, high viscosity, and emulsion forming tendency, all of which had significant impact on the equipment and piping design. The low GOR, relatively high power consumption, and location of the facility required the generators and ships boilers be capable of operating with stabilised crude as one of the fuel sources. In addition to the design issues noted, supply chain management challenges had to be overcome due to a contractual stipulation that required 65% Brazilian content. This paper will discuss some of the significant challenges that were faced and the solutions implemented to meet them including: Effects of heavy, high viscosity crude and emulsion on equipment selection and sizing, and piping sizing and layout; limited gas availability as production declines and the effect on power generation/drivers; use of reciprocating engine drivers for power generation; material selection; and interface management among the contractors involved. (author)

File list: Pol.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Lar.10.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.10.AllAg.3rd_instar.bed ...

File list: Pol.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Lar.50.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.50.AllAg.3rd_instar.bed ...

File list: ALL.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.Lar.50.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX1038029,SRX103803...SRX467060,SRX495306,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.50.AllAg.3rd_instar.bed ...

File list: Pol.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Lar.05.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287907,SRX28790...8,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.05.AllAg.3rd_instar.bed ...

File list: Pol.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Lar.20.AllAg.3rd_instar dm3 RNA polymerase Larvae 3rd instar SRX287908,SRX28790...7,SRX013070,SRX013082 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Lar.20.AllAg.3rd_instar.bed ...

143^rd and 144^th meetings of the Governing Board of the Pension Fund

CERN Multimedia

2006-01-01

During the meeting, the Board also approved a document setting out its position on the CERN debt to the Pension Fund, which would be submitted to the Finance Committee and Council in June. It underlined that the reimbursement of the debt would be advantageous for the Fund as well as for the Laboratory and that it would reduce the Fund's dependence on the employer, in line with international accounting practices. The second of the two meetings was essentially devoted to examining the actuary's report on the Fund's position with respect to its actuarial commitments as at 1st January 2006. The report, the first of its kind, follows the Board's decision to commission actuarial studies to check the Fund's position in open fund terms between three-yearly actuarial reviews. Based on the Fund's position as at the end of 2005 and taking account of the Council's decisions in December 2005, it reveals a net improvement in the Fund's long-term (30-year) financial balance. However, the actuary states in the conclusions t...

R&D Expenditures and Economic Growth Relationship in Turkey

OpenAIRE

Cuma BOZKURT

2015-01-01

In today's world, globalization has reached to such an extent that, investment in information and technology is inevitable to be integrated with global system and increase competitive power. Therefore, R&D investments are of high importance and priority for growth process of economy. This paper investigates the long-run relationship between R&D expenditure and economic growth using the Johansen co-integration and the vector error correction models. The research findings indicate that there is...

40 CFR 63.1018 - Reporting requirements.

Science.gov (United States)

2010-07-01

...) National Emission Standards for Equipment Leaks-Control Level 1 § 63.1018 Reporting requirements. (a... § 63.1007(e)(2) and those pumps complying with the closed vent system provisions of § 63.1007(e)(3). (iv) Number of compressors subject to the requirements of § 63.1012, excluding those compressors...

Leadership in R&D Activity in English and Welsh Universities

Science.gov (United States)

Mukan, Nataliya; Havrylyuk, Marianna; Prots, Maryana

2015-01-01

In the article, leadership in R&D activity in English and Welsh universities has been studied. The main objectives of the article are defined as following: to analyze the scientific literature which highlights different aspects of the problem under research, to identify the specificity of leadership practice in R&D, and to develop the…

The mismatch between the health research and development (R&D that is needed and the R&D that is undertaken: an overview of the problem, the causes, and solutions

Directory of Open Access Journals (Sweden)

Roderik F. Viergever

2013-10-01

Full Text Available One of the most pressing global health problems is that there is a mismatch between the health research and development (R&D that is needed and that which is undertaken. The dependence of health R&D on market incentives in the for-profit private sector and the lack of coordination by public and philanthropic funders on global R&D priorities have resulted in a global health R&D landscape that neglects certain products and populations and is characterised, more generally, by a distribution that is not ‘needs-driven’. This article provides an overview of the mismatch, its causes, and solutions.

Licensing Review in R+D Projects

OpenAIRE

Alessandro, Orsi

2014-01-01

FOSS packages are becoming ever more present in R&D projects carried out a variety of entities, including large corporations. I will focus on how legal risks associated with the use of FOSS licenses can be assessed and discuss measures directed to risk mitigation.

R&D Expenses and Share Value in The Japanese Stock Market

Directory of Open Access Journals (Sweden)

Sophie Nivoix

2014-11-01

Full Text Available The growing influence of technology in business activities is driving many firms to devote a greater amount of resources to research and development. It is therefore crucial to understand how the stock market evaluates the benefits of R&D. In this paper, our aim is to investigate whether Japanese investors have rewarded firms that heavily invest in R&D. We first document that R&D expenses have remained fairly stable relative to sales in the past eight years, but with large variations within and between industries. We then show that R&Dfirms have achieved a higher return relative to non-R&D firms. However, our regressions and investment simulations indicate that the relation between R&D intensity and stock returns is not significant, suggesting that the Japanese stock market is semi-strong efficient.

7 CFR 201.63 - Germination.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Germination. 201.63 Section 201.63 Agriculture... REGULATIONS Tolerances § 201.63 Germination. The following tolerances are applicable to the percentage of germination and also to the sum of the germination plus the hard seed when 400 or more seeds are tested. Mean...

Sequencing R&D Decisions in a Two-Period Duopoly with Spillovers

DEFF Research Database (Denmark)

Amir, Madjid; Amir, Rabah; Jin, Jim

2000-01-01

We compare simultaneous versus sequential moves in R&D decisions within an asymmetric R&D/Cournot model with linear demand (for differentiated products), general R&D costs, and spillovers. Simultaneous play and sequential play (with and without a specified leader) can emerge as appropriate...... formulations, depending on the ratios of spillover rate over demand cross-slope, but not on R&D efficiency. When at least one ratio is above 1/2, a sequential solution mitigates competition and leads to higher profits for each firm, and to higher social welfare. When uniquely specified, the stronger firm...

Regional R&D efficiency in Korea from static and dynamic perspectives

DEFF Research Database (Denmark)

Han, Ungkyu; Asmild, Mette; Kunc, Martin

2016-01-01

Research and development (R&D) efficiency has gained great attention in regional innovation research. This study examines the R&D efficiency patterns of 15 Korean regions for 2005–09. It employs data envelopment analysis to identify the regions' R&D performances relative to the best practices from...... the static perspective, and the Malmquist productivity index to evaluate their changes in performance within a given timeframe, providing a dynamic perspective. The results classify the Korean regions into deteriorating, lagging and improving groups, and indicate that most regions suffer from declining R...

Impact of GDP, spending on R&D, number of universities and scientific journals on research publications in pharmacological sciences in Middle East.

Science.gov (United States)

Meo, S A; Usmani, A M; Vohra, M S; Bukhari, I A

2013-10-01

Research in pharmacological science is vital to support the health needs of human beings. Measuring the research output provides information that forms the basis of strategic decisions. This study aimed to investigate the impact of Gross Domestic Product (GDP), spending on Research and Development (R&D), number of universities and scientific journals on research documents (papers), citable documents, citations per document and H-index in pharmacological science among Middle East countries. All the 16 Middle East countries were included in the study. The information regarding GDP, spending on R&D, total number of universities and indexed scientific journals were collected. We recorded the total number of research documents, citable documents, citations per document and H-index in pharmacological science during the period 1996-2011. The main sources for information were World Bank, Web of Science, Journal Citation Reports (Thomson Reuters) and SCI-mago/Scopus. The mean per capita GDP of all the Middle East countries is 18125.49±5386.28 US$, spending on R&D 0.63±0.28% of GDP in US$, number of universities 36.56±11.33 and mean ISI indexed journal are 8.25±3.93. The number of research documents published in pharmacological science among the Middle East countries during the period 1996-2011 is 1344.44±499.34; citable documents 1286.37±476.34; citations per document 7.62± 0.84; and H-index is 30.68±6.32. There was a positive correlation between spending on R&D and citations per documents (r = 0.56, p = 0.02), H-Index (r = 0.56, p = 0.02); number of universities and research documents (r = 0.72, p = 0.002), citable documents (r = 0.72, p = 0.001); ISI indexed journals and research documents (r = 0.88, p = 0.0001), citable documents (r = 0.88, p = 0.0001), H-Index (r = 0.67, p = 0.004). However, there was no correlation between the GDP per capita and research outcome in pharmacological science. There is a positive association between spending on R&D, number of

How transfer of R&D to emerging markets nurtures global innovation performance

DEFF Research Database (Denmark)

Harryson, Sigvald; Søberg, Peder Veng

2009-01-01

In the context of global R&D, we connect literature on knowledge management to a network-based theoretical framework helpful to explain the impact of R&D globalisation on innovation performance. This framework is applied to two case companies, both global leaders within their respective industries...... established R&D offsprings to improve overall innovation performance. Pack Tech illustrates this through a collaboration-intensive approach to university competitions in China....

36 CFR 251.63 - Reciprocity.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Reciprocity. 251.63 Section 251.63 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Special Uses § 251.63 Reciprocity. If it is determined that a right-of-way shall be needed by the United States...

R&D subsidiary isolation in knowledge-intensive industries: evidence from Austria

NARCIS (Netherlands)

Williams, C.; Nones, B.

2009-01-01

We investigate R&D subsidiary isolation within Multinational Corporations (MNCs) competing in knowledge-intensive industries. For such MNCs, accessing knowledge and nurturing the innovative potential of R&D subsidiaries is vital for on-going competitiveness. This, according to conventional thinking,

40 CFR 63.1546 - Test methods.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Test methods. 63.1546 Section 63.1546... Hazardous Air Pollutants for Primary Lead Smelting § 63.1546 Test methods. (a) The following procedure shall....1543(a)(1) through § 63.1543(a)(9) shall be determined according to the following test methods in...

Good Practice Policy Framework for Energy Technology Research Development and Demonstration (RD and D)

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

The transition to a low carbon economy clearly requires accelerating energy innovation and technology adoption. Governments have an important role in this context. They can help by establishing the enabling environment in which innovation can thrive, and within which effective and efficient policies can be identified, with the specific goal of advancing research, development, demonstration and, ultimately, deployment (RDD&D) of clean energy technologies. At the front end of the innovation process, significant increases in, and restructuring of, global RD&D efforts will be required, combined with well-targeted government RD&D policies. The development of a clear policy framework for energy technology RD&D, based on good practices, should include six elements: Coherent energy RD&D strategy and priorities; Adequate government RD&D funding and policy support; Co-ordinated energy RD&D governance; Strong collaborative approach, engaging industry through public private partnerships (PPPs); Effective RD&D monitoring and evaluation; and Strategic international collaboration. While countries have been favouring certain technologies over others, based on decisions on which areas are to receive funding, clear priorities are not always determined through structured analysis and documented processes. A review of stated energy RD&D priorities, based on announced technology programmes and strategies, and recent spending trends reveals some important deviations from stated priorities and actual RD&D funding.

Managing the Experience in IT R&D Department

Institute of Scientific and Technical Information of China (English)

CAO Huan; MA Shun-dao; LI Yong-jian

2006-01-01

How to manage the experience in IT R&D department is vital for the IT company.The primary purpose of this paper is to probe into the natural character of the experience in IT R&D department, and put forward the strategy of how to manage it. The research on the strategies is applied in a mobile phone game software company to further validate its efficiency.The results indicate using the strategies of "a learning history" and "dynamic knowledge map" can improve the performance level and more attentions should focus on the relationship between people and how to communicate.

Multinational Taxation and R&D Investments

NARCIS (Netherlands)

de Waegenaere, A.; Sansing, R.C.; Wielhouwer, J.L.

2012-01-01

This study examines the effects of taxation on the incentives of multinational firms to develop and use intellectual property. We model optimal investment and production decisions by firms that engage in a patent race by making R&D investments. We investigate how taxes affect the level and

Multinational taxation and R&D investments

NARCIS (Netherlands)

De Waegenaere, A.M.B.; Sansing, R.; Wielhouwer, J.L.

2012-01-01

This study examines the effects of taxation on the incentives of multinational firms to develop and use intellectual property. We model optimal investment and production decisions by firms that engage in a patent race by making R&D investments. We investigate how taxes affect the level and

40 CFR 63.547 - Test methods.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Test methods. 63.547 Section 63.547... Hazardous Air Pollutants from Secondary Lead Smelting § 63.547 Test methods. (a) The following test methods...), and 63.545(e): (1) Method 1 shall be used to select the sampling port location and the number of...

12 CFR 4.63 - Policy.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Policy. 4.63 Section 4.63 Banks and Banking...; Contracting for Goods and Services § 4.63 Policy. The OCC's policy is to ensure that MWOBs and IDOBs have the... into for goods and services, whether generated by the headquarters office in Washington, DC, or any...

Can open-source drug R&D repower pharmaceutical innovation?

Science.gov (United States)

Munos, B

2010-05-01

Open-source R&D initiatives are multiplying across biomedical research. Some of them-such as public-private partnerships-have achieved notable success in bringing new drugs to market economically, whereas others reflect the pharmaceutical industry's efforts to retool its R&D model. Is open innovation the answer to the innovation crisis? This Commentary argues that although it may likely be part of the solution, significant cultural, scientific, and regulatory barriers can prevent it from delivering on its promise.

An Allelic Series of Trp63 Mutations Defines TAp63 as a Modifier of EEC Syndrome

Science.gov (United States)

Lindahl, Emma Vernersson; Garcia, Elvin L.; Mills, Alea A.

2014-01-01

Human Ectrodactyly, Ectodermal dysplasia, Clefting (EEC) syndrome is an autosomal dominant developmental disorder defined by limb deformities, skin defects, and craniofacial clefting. Although associated with heterozygous missense mutations in TP63, the genetic basis underlying the variable expressivity and incomplete penetrance of EEC is unknown. Here we show that mice heterozygous for an allele encoding the Trp63 p.Arg318His mutation, which corresponds to the human TP63 p.Arg279His mutation found in patients with EEC, have features of human EEC. Using an allelic series, we discovered that whereas clefting and skin defects are caused by loss of Trp63 function, limb anomalies are due to gain- and/or dominant-negative effects of Trp63. Furthermore, we identify TAp63 as a strong modifier of EEC-associated phenotypes with regard to both penetrance and expressivity. PMID:23775923

File list: ALL.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.Lar.05.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX104964,SRX104963,...SRX287718,SRX331401,SRX287658,SRX331366,SRX287906,SRX287678 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.05.AllAg.3rd_instar.bed ...

File list: ALL.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.Lar.10.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX104963,SRX104968,...SRX287718,SRX022334,SRX104976,SRX467107,SRX013086,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.10.AllAg.3rd_instar.bed ...

File list: ALL.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.Lar.20.AllAg.3rd_instar dm3 All antigens Larvae 3rd instar SRX1038029,SRX103803...SRX013082,SRX467107,SRX016173,SRX215499,SRX495243,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Lar.20.AllAg.3rd_instar.bed ...

File list: Unc.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Unc.Lar.50.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX022335,SRX032124,SRX032123,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.50.AllAg.3rd_instar.bed ...

Calculations for the excitation functions of the 63Cup, n63Zn, 63Cup, 2n62Zn and 65Cup, n65Zn reactions

International Nuclear Information System (INIS)

Gul, K.

2001-01-01

Calculations for the excitation functions of 63 Cup, n 63 Zn, 63 Cup, 2n 62 Zn and 65 Cup, n 65 Zn reactions have been carried out in 3-30 MeV energy range using statistical and pre-equilibrium nuclear reaction models. The calculations have been compared with reported measurements and discussed

RD50 recent results: Development of radiation hard sensors for SLHC

CERN Document Server

Macchiolo, Anna

2009-01-01

The need for radiation hard semiconductor detectors for the tracker regions in high energy physics experiments at a future high luminosity hadron collider, like the proposed LHC upgrade, has led to the formation of the CERN RD50 collaboration. The R&D directions of RD50 follow two paths: the optimization of radiation hard bulk materials (Material Engineering) and the development of new detector designs (Device Engineering) as 3D sensors, thin sensors and n-in-p sensors. Some of the RD50 most recent results about silicon detectors are reported in this paper, with special reference to: (i) identification of defects responsible for long term annealing, (ii) charge collection efficiency of irradiated planar devices, in particular n-in-p microstrip detectors and epitaxial diodes, (iii) charge collection efficiency of double-type column 3D detectors, (iv) comparison of the performances of FZ and MCZ structures under mixed irradiation.

Knowledge Complementarity of a Firm’s Internal and External R&D Capabilities

OpenAIRE

Koski, Heli; Svento, Rauli

2014-01-01

We use data from over 1500 Finnish companies for the years 2006-2008 and 2008-2010 to explore complementarity of a firm’s R&D strategy with its external knowledge acquisition and innovation collaboration strategies. We define knowledge complementarity (tacit knowledge complementarity) of R&D capabilities to exist when increase in investments in R&D also increases marginal returns from broader external knowledge search (deeper innovation collaboration with external partners). Our estimation re...

Technological Similarity, Post-acquisition R&D Reorganization, and Innovation Performance in Horizontal Acquisition

DEFF Research Database (Denmark)

Colombo, Massimo G.; Rabbiosi, Larissa

2014-01-01

This paper aims to disentangle the mechanisms through which technological similarity between acquiring and acquired firms influences innovation in horizontal acquisitions. We develop a theoretical model that links technological similarity to: (i) two key aspects of post-acquisition reorganization...... of acquired R&D operations – the rationalization of the R&D operations and the replacement of the R&D top manager, and (ii) two intermediate effects that are closely associated with the post-acquisition innovation performance of the combined firm – improvements in R&D productivity and disruptions in R......&D personnel. We rely on PLS techniques to test our theoretical model using detailed information on 31 horizontal acquisitions in high- and medium-tech industries. Our results indicate that in horizontal acquisitions, technological similarity negatively affects post-acquisition innovation performance...

File list: Unc.Lar.10.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Unc.Lar.10.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX032124,SRX032123,SRX022335,SRX022334,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.10.AllAg.3rd_instar.bed ...

File list: Unc.Lar.20.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Unc.Lar.20.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038029,SRX103803...1,SRX1038032,SRX1038030,SRX022335,SRX032124,SRX022334,SRX032123,SRX013058 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.20.AllAg.3rd_instar.bed ...

File list: Unc.Lar.05.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Unc.Lar.05.AllAg.3rd_instar dm3 Unclassified Larvae 3rd instar SRX1038031,SRX103802...9,SRX1038032,SRX1038030,SRX022335,SRX022334,SRX032124,SRX013058,SRX032123 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Unc.Lar.05.AllAg.3rd_instar.bed ...

Managing the strategic network relations between corporate R&D and business

NARCIS (Netherlands)

Fortuin, F.T.J.M.; Omta, S.W.F.

2006-01-01

The present paper addresses the important issue of the management of the strategic network relations between corporate R&D and business. In a large technology-based multinational company (+/- 30,000 employees) an instrument that provides regular feedback to both corporate R&D and business

From mind to market: A global, dynamic analysis of R&D

NARCIS (Netherlands)

Hinloopen, J.; Smrkolj, G.; Wagener, F.

2013-01-01

Existing models of R&D are not easily reconciled with four observable aspects of R&D: initial technologies (ideas) need to be developed further, only a minority of initial ideas are successfully brought to the market, production and process innovations take place simultaneously (whereby, initially,

Molecular genetic characterization of the RD-114 gene family of endogenous feline retroviral sequences.

Science.gov (United States)

Reeves, R H; O'Brien, S J

1984-01-01

RD-114 is a replication-competent, xenotropic retrovirus which is homologous to a family of moderately repetitive DNA sequences present at ca. 20 copies in the normal cellular genome of domestic cats. To examine the extent and character of genomic divergence of the RD-114 gene family as well as to assess their positional association within the cat genome, we have prepared a series of molecular clones of endogenous RD-114 DNA segments from a genomic library of cat cellular DNA. Their restriction endonuclease maps were compared with each other as well as to that of the prototype-inducible RD-114 which was molecularly cloned from a chronically infected human cell line. The endogenous sequences analyzed were similar to each other in that they were colinear with RD-114 proviral DNA, were bounded by long terminal redundancies, and conserved many restriction sites in the gag and pol regions. However, the env regions of many of the sequences examined were substantially deleted. Several of the endogenous RD-114 genomes contained a novel envelope sequence which was unrelated to the env gene of the prototype RD-114 env gene but which, like RD-114 and endogenous feline leukemia virus provirus, was found only in species of the genus Felis, and not in other closely related Felidae genera. The endogenous RD-114 sequences each had a distinct cellular flank which indicates that these sequences are not tandem but dispersed nonspecifically throughout the genome. Southern analysis of cat cellular DNA confirmed the conclusions about conserved restriction sites in endogenous sequences and indicated that a single locus may be responsible for the production of the major inducible form of RD-114. Images PMID:6090693

Expert judgments about RD&D and the future of nuclear energy.

Science.gov (United States)

Anadón, Laura D; Bosetti, Valentina; Bunn, Matthew; Catenacci, Michela; Lee, Audrey

2012-11-06

Probabilistic estimates of the cost and performance of future nuclear energy systems under different scenarios of government research, development, and demonstration (RD&D) spending were obtained from 30 U.S. and 30 European nuclear technology experts. We used a novel elicitation approach which combined individual and group elicitation. With no change from current RD&D funding levels, experts on average expected current (Gen. III/III+) designs to be somewhat more expensive in 2030 than they were in 2010, and they expected the next generation of designs (Gen. IV) to be more expensive still as of 2030. Projected costs of proposed small modular reactors (SMRs) were similar to those of Gen. IV systems. The experts almost unanimously recommended large increases in government support for nuclear RD&D (generally 2-3 times current spending). The majority expected that such RD&D would have only a modest effect on cost, but would improve performance in other areas, such as safety, waste management, and uranium resource utilization. The U.S. and E.U. experts were in relative agreement regarding how government RD&D funds should be allocated, placing particular focus on very high temperature reactors, sodium-cooled fast reactors, fuels and materials, and fuel cycle technologies.

Evaluation of long-term RD and D programs in the presence of market uncertainties

International Nuclear Information System (INIS)

Hazelrigg, G.A. Jr.

1982-01-01

Long-term research, development, and demonstration (RD and D) programs such as fusion research can span several decades, progressing through a number of discrete RD and D phases. Pursuit of a technology such as fusion does not mean commitment to the entire RD and D program, but only to the next phase of RD and D. The evaluation of a long-term RD and D program must account for the decision process to continue, modify, or discontinue the program upon completion of each RD and D phase, the technological uncertainties inherent in a long-term RD and D program, and the uncertainty inherent in the future marketplace for the technology if and when it becomes available. Presented here is a methodology that does this. An application of the methodology to fusion research is included. The example application shows that the perceived economic value of fusion research is strongly dependent on market uncertainty, with increasing market uncertainty yielding greatly increased perceived value to the research effort. 7 references, 8 figures, 2 tables

A Research on the Construction of University R&D Management Team in China

Science.gov (United States)

Jia, Ning

2007-01-01

The system of Chinese universities R&D as a branch of the system of the whole country R&D, has a great effect on the development and innovation of the country's science and technique. Consequently, it's important to construct an effective management team with high diathesis for University R&D management. Based on the statistics of the…

Aspiration Levels and R&D Search in Young Technology-Based Firms

DEFF Research Database (Denmark)

Candi, Marina; Saemundsson, Rognvaldur; Sigurjonsson, Olaf

Decisions about allocation of resources to research and development (R&D), referred to here as R&D search, are critically important for competitive advantage. Using panel data collected yearly over a period of nine years, this paper re-visits existing theories of backward-looking and forward-look...

Fleet DNA Brings Fleet Data to Life, Informs R&D | NREL

Science.gov (United States)

Fleet DNA Brings Fleet Data to Life, Informs R&D Science and Technology Highlights Highlights in Research & Development Fleet DNA Brings Fleet Data to Life, Informs R&D Key Research Results Achievement Built on over 11.5 million miles of vehicle operations data, Fleet DNA helps users

Histopathologie der IgG4-RD

DEFF Research Database (Denmark)

Detlefsen, S; Klöppel, G

2016-01-01

infiltrate, 2) storiform fibrosis and 3) obliterative phlebitis. The diagnosis is further supported by immunohistochemical demonstration of an increased infiltration of IgG4-positive plasma cells and an elevated IgG4/IgG ratio. The morphological criteria of IgG4-RD are in most cases detectable in biopsies...

Report of the 3rd European fusion physics workshop, Segovia 13-15 December 1995

International Nuclear Information System (INIS)

Todd, T.N.; Jones, T.T.C.; Moreau, D.; Zohm, H.

1997-01-01

The 3rd EFPW was convened in December 1995 at Segovia, with the support of Eurotom and CIEMAT. The established pattern for these meetings was followed, beginning with a range of topical themes of interest to the magnetic confinement fusion research community. Subsequent presentations moved on to summarize progress in experiments on JET and the design activity for ITER. The topical theme this year comprised tokamak operational limits, disruption phenomena and transport issues (including the role of plasma edge effects, dimensionless scaling analysers and 'non-local' dependences). Also discussed were tokamak concept improvements, with additional contributions emphasizing the synergistic role of stellarators. JET highlights reported were the achievements of the experiments with the Mk1 divertor, high fusion performance plasmas, and exploratory work on discharge optimization techniques (such as reversed magnetic shear). This article summarizes the proceedings of the workshop on the topical themes and the JET results, including a number of points raised in the associated discussion sessions. (author)

R&D outsourcing contract for the unverified value of tacit knowledge sharing

Directory of Open Access Journals (Sweden)

Han Song

2015-11-01

Full Text Available Purpose: The purpose of this paper is to provide a R&D outsourcing contract design framework to incent R&D outsourcing service providers sharing tacit and explicit knowledge. Design/methodology/approach: The author uses the principal-agent theory to builds multitask principal-agent model which focuses on two cases. One case is that the effort costs of explicit and tacit knowledge sharing are complementary, but another is the effort costs are substitutable. Findings: It was found that when the effort costs of explicit and tacit knowledge sharing are mutually complementary the multitask R&D outsourcing contract can incent tacit knowledge sharing. Moreover, the multitask R&D outsourcing contract can motivate the effort of explicit knowledge sharing to achieve system optimization, but it fails to motivate the effort of tacit knowledge sharing to achieve system optimization. Research limitations/implications: In this paper we only consider that the outsourcing relationship is short-term, so the multitask R&D outsourcing contract is formal. In fact, the outsourcing relationship may be long-term, so the multitask R&D outsourcing contract is informal. In the long-term cooperation the buyer can promise some reward which cannot be verified by court. service providers choose to trust the promise of the buyer first. Once the buyer don’t fulfill the promise, they not only lose the trust of service providers in this cooperation, but also lose social trust and are seen as dishonest enterprises. Practical implications: Our study provides a theoretical model for formulating an effective R&D outsourcing contract and promoting the transfer of explicit and tacit knowledge sharing. Originality/value: The paper extends prior literature by designing multitask R&D outsourcing contract to share the tacit knowledge. We not only consider the cost of substitution relationship between tacit knowledge and explicit knowledge, but also considered the cost of

Market Share, R&D Cooperation, and EU Competition Policy

OpenAIRE

Richard Rubble; Bruno Versaevel

2009-01-01

Working Paper GATE 2009-10; Current EU policy exempts horizontal R&D agreements from antitrust con- cerns when the combined market shares of participants are low enough. This paper argues that existing theory does not support limiting the exemption to low market shares. This is done by introducing a set of non-innovating outside firms to the standard framework to assess what link might exist between the market share of innovating firms and the product market benefits of cooperation. With R&D out...

Intended R&D Knowledge Spillover - Strategy for Innovation Leadership

DEFF Research Database (Denmark)

Harryson, Sigvald; Søberg, Peder Veng

2009-01-01

, inhibit companies striving for innovation leadership. In our enquiry into R&D knowledge spillover effects on innovation, we develop case studies from Fastcar and Bigpack. The resulting theoretical framework, built on selected networking and knowledge creation theories, is illustrated through the two case...... studies and useful for further analysis of positive R&D knowledge spillover effects. By proactively facilitating knowledge sharing with relevant parts of the surrounding environment, the company enables itself to feed knowledge into its surrounding environment - thereby developing the innovation potential...

Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana.

Directory of Open Access Journals (Sweden)

Christian Gu

Full Text Available RD21-like proteases are ubiquitous, plant-specific papain-like proteases typified by carrying a C-terminal granulin domain. RD21-like proteases are involved in immunity and associated with senescence and various types of biotic and abiotic stresses. Here, we interrogated Arabidopsis RD21 regulation and trafficking by site-directed mutagenesis, agroinfiltration, western blotting, protease activity profiling and protein degradation. Using an introduced N-glycan sensor, deglycosylation experiments and glyco-engineered N. benthamiana plants, we show that RD21 passes through the Golgi where it becomes fucosylated. Our studies demonstrate that RD21 is regulated at three post-translational levels. Prodomain removal is not blocked in the catalytic Cys mutant, indicating that RD21 is activated by a proteolytic cascade. However, RD21 activation in Arabidopsis does not require vacuolar processing enzymes (VPEs or aleurain-like protease AALP. In contrast, granulin domain removal requires the catalytic Cys and His residues and is therefore autocatalytic. Furthermore, SDS can (re-activate latent RD21 in Arabidopsis leaf extracts, indicating the existence of a third layer of post-translational regulation, possibly mediated by endogenous inhibitors. RD21 causes a dominant protease activity in Arabidopsis leaf extracts, responsible for SDS-induced proteome degradation.

Electric Motor Thermal Management R&D

Energy Technology Data Exchange (ETDEWEB)

Bennion, Kevin

2016-06-07

Thermal management enables more efficient and cost-effective motors. This Annual Merit Review presentation describes the technical accomplishments and progress in electric motor thermal management R&D over the last year. This project supports a broad industry demand for data, analysis methods, and experimental techniques to improve and better understand motor thermal management.

2016 Wireless Spectrum R&D Project Inventory

Data.gov (United States)

Networking and Information Technology Research and Development, Executive Office of the President — The Wireless Spectrum R&D (WSRD) Interagency Working Group (IWG) was formed in late 2010 to coordinate spectrum-related research and development activities both...

Charged-Higgs on R_D"_("_*"_), τ polarization, and FBA

International Nuclear Information System (INIS)

Chen, Chuan-Hung; Nomura, Takaaki

2017-01-01

We study the influence of a charged-Higgs on the excess of branching fraction ratio, R_M = BR(anti B → Mτ anti ν_τ)/BR(anti B → Ml anti ν_l) (M = D, D*), in a generic two-Higgs-doublet model. In order to investigate the lepton polarization, the detailed decay amplitudes with lepton helicity are given. When the charged-Higgs is used to resolve excesses, it is found that two independent Yukawa couplings are needed to explain the R_D and R_D_* anomalies. We show that when the upper limit of BR(B_c → τ anti ν_τ) < 30% is included, R_D can be significantly enhanced while R_D_* < 0.27. With the BR(B_c → τ anti ν_τ) constraint, we find that the τ-lepton polarizations can be still affected by the charged-Higgs effects, where the standard model (SM) predictions are obtained: P"τ_D ∼ 0.324 and P"τ_D_* ∼ -0.500, and they can be enhanced to be P"τ_D ∼ 0.5 and P"τ_D_* ∼ -0.41 by the charged-Higgs. The integrated lepton forward-backward asymmetry (FBA) is also studied, where the SM result is anti A"D""(""*"")","τ_F_B ∼ -0.359(0.064), and they can be enhanced (decreased) to be anti A"D""(""*"")","τ_F_B ∼ -0.33(0.02). (orig.)

Mental health services and R&D in South Korea.

Science.gov (United States)

Roh, Sungwon; Lee, Sang-Uk; Soh, Minah; Ryu, Vin; Kim, Hyunjin; Jang, Jung Won; Lim, Hee Young; Jeon, Mina; Park, Jong-Ik; Choi, SungKu; Ha, Kyooseob

2016-01-01

World Health Organization has asserted that mental illness is the greatest overriding burden of disease in the majority of developed countries, and that the socioeconomic burden of mental disease will exceed that of cancer and cardiovascular disorders in the future. The life-time prevalence rate for mental disorders in Korea is reported at 27.6 %, which means three out of 10 adults experience mental disorders more than once throughout their lifetime. Korea's suicide rate has remained the highest among Organization for Economic Cooperation and Development (OECD) nations for 10 consecutive years, with 29.1 people out of every 100,000 having committed suicide. Nevertheless, a comprehensive study on the mental health services and the Research and Development (R&D) status in Korea is hard to find. Against this backdrop, this paper examines the mental health services and the R&D status in Korea, and examines their shortcomings and future direction. The paper discusses the mental health service system, budget and human resources, followed by the mental health R&D system and budget. And, by a comparison with other OECD countries, the areas for improvement are discussed and based on that, a future direction is suggested. This paper proposes three measures to realize mid and long-term mental health promotion services and to realize improvements in mental health R&D at the national level: first, establish a national mental health system; second, forecast demand for mental health; and third, secure and develop mental health professionals.

Unique challenges lead to innovative solutions on PETROBRAS' P-63 project

Energy Technology Data Exchange (ETDEWEB)

Clark, David J.; Dakin, Brian V. [Amec Oil and Gas Americas, Houston, TX (United States)

2012-07-01

In early 2010, PETROBRAS accepted bids for the design, fabrication, installation and operation of the P-63 FPSO for the first three years of production starting in 2013. The field is to be produced using dry tree wells located at the adjacent P-61 tension leg platform (TLP) and subsea wells flowing to the P-63 floating production storage and offloading (FPSO) vessel. Production processing facilities are located primarily on the FPSO with multiple fluid transfer lines directing raw produced fluids from P-61 to P-63 for processing. The oil is a heavy crude with low associated gas, high viscosity, and emulsion forming tendency, all of which had significant impact on the equipment and piping design. The low GOR, relatively high power consumption, and location of the facility required the generators and ships boilers be capable of operating with stabilised crude as one of the fuel sources. In addition to the design issues noted, supply chain management challenges had to be overcome due to a contractual stipulation that required 65% Brazilian content. This paper will discuss some of the significant challenges that were faced and the solutions implemented to meet them including: Effects of heavy, high viscosity crude and emulsion on equipment selection and sizing, and piping sizing and layout; limited gas availability as production declines and the effect on power generation/drivers; use of reciprocating engine drivers for power generation; material selection; and interface management among the contractors involved. (author)

Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis

DEFF Research Database (Denmark)

Rosenkrands, Ida; Aagaard, Claus; Weldingh, Karin

2008-01-01

Forty-seven Mycobacterium tuberculosis genes from the 'regions of difference' RD2-7, RD9-13 and RD15 were cloned and expressed, and the purified recombinant proteins were screened for their serodiagnostic potential. Evaluation of six selected proteins in serum samples from Danish resident tubercu...

Service-sector Competition, Innovation and R&D

DEFF Research Database (Denmark)

Tingvall, Patrick Gustavsson; Karpaty, Patrik

2011-01-01

The central prediction of the Aghion, Bloom, Blundell and Howitt model is an inverted U-shaped relationship between innovation and competition. The model is built on the assumption of a product market and has not yet been tested on the service sector. Using detailed firm-level data on Swedish...... service-sector firms, we find evidence of an inverse U-shaped relationship for exporting service-sector firms. A further breakdown of innovation expenditures shows that the inverse U-shaped pattern holds for intramural R&D and training, but not for extramural R&D. Finally, the results indicate...... that as competition increases, small firms tend to seek strategic alliances with competitors, whereas large firms tend to reduce collaboration with competitors. The behavior of large firms can partly be due to their superior capacity to handle innovation projects internally, which will become more important...

Community Targets for JWST's Early Release Science Program: Evaluation of Transiting Exoplanet WASP-63b.

Science.gov (United States)

Kilpatrick, Brian; Cubillos, Patricio; Bruno, Giovanni; Lewis, Nikole K.; Stevenson, Kevin B.; Wakeford, Hannah; Blecic, Jasmina; Burrows, Adam Seth; Deming, Drake; Heng, Kevin; Line, Michael R.; Madhusudhan, Nikku; Morley, Caroline; Waldmann, Ingo P.; Transiting Exoplanet Early Release Science Community

2017-06-01

We present observations of the Hubble Space Telescope (HST) ``A Preparatory Program to Identify the Single Best Transiting Exoplanet for JWST Early Release Science" for WASP-63b, one of the community targets proposed for the James Webb Space Telescope (JWST) Early Release Science (ERS) program. A large collaboration of transiting exoplanet scientists identified a set of ``community targets" which meet a certain set of criteria for ecliptic latitude, period, host star brightness, well constrained orbital parameters, and strength of spectroscopic features. WASP-63b was one of the targets identified as a potential candidate for the ERS program. It is presented as an inflated planet with a large signal. It will be accessible to JWST approximately six months after the planned start of Cycle 1/ERS in April 2019 making it an ideal candidate should there be any delays in the JWST timetable. Here, we observe WASP-63b to evaluate its suitability as the best target to test the capabilities of JWST. Ideally, a clear atmosphere will be best suited for bench marking the instruments ability to detect spectroscopic features. We can use the strength of the water absorption feature at 1.4 μm as a way to determine the presence of obscuring clouds/hazes. The results of atmospheric retrieval are presented along with a discussion on the suitability of WASP-63b as the best target to be observed during the ERS Program.

R&D figures 'distorted' by defence spending

CERN Multimedia

Coghlan, A

1990-01-01

A report published by the House of Lords Select Committee on Science and Technology, claims that government figures for R&D spending are misleading. They apparently include military projects that are more concerned with product development than original research.

Lessons learned from Ebola Vaccine R&D during a public health emergency.

Science.gov (United States)

Kieny, Marie-Paule

2018-02-16

In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic. Since 2015, WHO expert teams and partners are implementing a novel R&D model for emerging infectious pathogens which are the most likely to cause severe outbreaks in the future, and for which no or only few medical countermeasures are available: the WHO R&D Blueprint. The objective for the Blueprint is the fostering of a R&D environment which is prepared for quickly and effectively responding to outbreaks due to emerging infectious disease.

The Latin American University and R&D.

Science.gov (United States)

Vessuri, Hebe, Ed.; And Others

1995-01-01

Includes "Introduction" (Vessuri); "University-Industry Relationships and Periphery Development: The Case of the University of Campinas, Brazil" (Dagnino); "R&D at the Autonomous National University of Mexico" (Chazaro); and "Scientific Activities in Large Institutions of Higher Education: The Case of the…

The physical limits to economic growth by R&D funded innovation

International Nuclear Information System (INIS)

Beaudreau, Bernard C.; Lightfoot, H. Douglas

2015-01-01

For over three decades, worldwide R&D expenditure has risen steadily, reaching $1.3 trillion in 2011. Underlying this unprecedented growth is a deeply-held belief that R&D is a prime mover of economic growth. Ironically, despite three decades of massive R&D expenditure, growth levels have remained substantially lower than that of the immediate post World War II period. This raises important theoretical questions regarding R&D and its impact on growth per se. For example, R&D-growth has been modeled and continues to be modeled as an unbounded set. This has not been inconsequential because it has introduced an upward bias in growth projections as evidenced in the literature. More importantly, are there physically-determined upper limits to R&D-based growth and, if so, what are they? This paper uses the physical sciences to map the physical limits to R&D-based innovation. A consilient model of economic growth is presented and upper bounds for energy efficiency-based growth rates are provided, both for individual energy sectors and globally. We find that with economic growth by innovation limited by physical conditions, increasing the rate of economic growth can only come through increasing the rate of energy consumption. - Highlights: • Worldwide, R&D expenditures have grown steadily yet economic growth remains anemic. • This paper examines the physics of process-based R&D using a consilient model of wealth creation. • Growth is formalized in terms of (i) energy consumption growth and (ii) changes in energy efficiency. • Detailed estimates of changes in energy efficiency are provided for the period 1990–2100. • The results of the paper establish the upper bound of changes in energy efficiency at 0.68 percent per year

How to increase R&D in transition economies? Evidence from Slovenia

Czech Academy of Sciences Publication Activity Database

Domadenik, P.; Prašnikar, J.; Švejnar, Jan

2008-01-01

Roč. 12, č. 1 (2008), s. 193-208 ISSN 1363-6669 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : transition * research and development * R&D investment Subject RIV: AH - Economics Impact factor: 0.635, year: 2008 http://www3.interscience.wiley.com/journal/119417634/abstract

Allocation of R&D Equipment Expenditure Based on Organisation Discipline Profiles

Science.gov (United States)

Wells, Xanthe E.; Foster, Nigel; Finch, Adam; Elsum, Ian

2017-01-01

Sufficient and state-of-the-art research equipment is one component required to maintain the research competitiveness of a R&D organisation. This paper describes an approach to inform more optimal allocation of equipment expenditure levels in a large and diverse R&D organisation, such as CSIRO. CSIRO is Australia's national science agency,…

Perspectives of automotive battery R&D in China, Germany, Japan, and the USA

Science.gov (United States)

Bresser, Dominic; Hosoi, Kei; Howell, David; Li, Hong; Zeisel, Herbert; Amine, Khalil; Passerini, Stefano

2018-04-01

Lithium(-ion) batteries are and will be the battery technology of choice for a wide range of applications - including electric vehicles - for several years to come. Nonetheless, to foster the transition from combustion engine vehicles to a fully electrified transportation, further progress is needed. In this regard, the annual International Conference on Advanced Lithium Batteries for Automobile Applications (ABAA) targets the intensive exchange of the involved industrial and research entities to jointly ensure the further progress of this technology. During the past meeting, ABAA-10, held in October 2017 in Chicago, IL, USA, representatives of China, Germany, Japan, and the USA provided a comprehensive overview of the current and future battery R&D activities in their countries, depicting a highly insightful survey about partially concurrent, partially complementary research and funding strategies. The given presentations are provided in the Supplementary Material for this Special Perspective, while this perspective article may serve as brief introduction to the general development in the field concerning the overall EV sales and common considerations regarding future material developments.

25 CFR 63.4 - Information collection.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 63.4 Section 63.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Purpose, Policy, and Definitions § 63.4 Information collection. The information...

45 CFR 1801.63 - Scholar Accountability.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Scholar Accountability. 1801.63 Section 1801.63 Public Welfare Regulations Relating to Public Welfare (Continued) HARRY S. TRUMAN SCHOLARSHIP FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Duration of Scholarship § 1801.63 Scholar Accountability. (a) A...

10 CFR 1040.63 - Discrimination prohibited.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Discrimination prohibited. 1040.63 Section 1040.63 Energy... Provisions § 1040.63 Discrimination prohibited. (a) General. No qualified handicapped person shall, on the... subjected to discrimination under any program or activity that receives Federal financial assistance from...

Conducting pharmaceutical R&D in India - Critical components of entry strategies.

Science.gov (United States)

Gulati, Rajiv

2008-11-01

In the face of challenges associated with expiring patents, the rising cost of R&D and pressure on pricing, most major pharmaceutical companies are seeking ways to enhance productivity, reduce costs and augment the late-stage new-product pipeline. Exploiting the R&D capabilities in India is one option that can be helpful in achieving these goals. However, considering the challenges involved, important considerations must be incorporated to ensure that an appropriate R&D strategy is meticulously implemented. In creating suitable strategies, it is important to understand the historical perspective that provides insight into the relative strengths of companies in India across the R&D value chain. In addition, the ability of a company to take risks and commit to a long-term investment will largely determine the model that is selected. To implement a given model, an understanding of cultural differences and infrastructural challenges that must be overcome is extremely important. The ultimate factor that determines success or failure, however, lies within the organization. Preparing an organization by establishing appropriate structures and processes is imperative.

R&D, Marketing, and the Success of Next-Generation Products

OpenAIRE

Elie Ofek; Miklos Sarvary

2003-01-01

This paper studies dynamic competition in markets characterized by the introduction of technologically advanced next-generation products. Firms invest in new product effort in an attempt to attain industry leadership, thus securing high profits and benefiting from advantages relevant for the success of future product generations. The analysis reveals that when the current leader possesses higher research and development (R&D) competence, it tends to investin R&D than rivals and to retain its ...

Technical committee meeting on Liquid Metal Fast Reactor (LMFR) developments. 33rd annual meeting of the International Working Group on Fast Reactors (IWG-FR). Working material

International Nuclear Information System (INIS)

2000-01-01

Over the past 33 years, the IAEA has actively encouraged and advocated international cooperation in fast reactor technology. The present publication contains information on the status of fast reactor development and on worldwide activities in this advanced nuclear power technology during 1999/2000, as reported at the 33. annual meeting of the International Working Group on Fast Reactors. It is intended to provide information regarding the current status of LMFR development in IAEA Member States

FAA perspectives on historical wake turbulence R&D to recent operational implementations

Science.gov (United States)

2017-06-03

A major intent of this presentation is to delineate why the many years of wake turbulence R&D are finally yielding beneficial operational implementations. It will highlight lessons learned from past R&D and going forward for NextGen and beyond.

Impact of GDP, spending on R&D, the number of universities and scientific journals on research publications in environmental sciences in the Middle East

Directory of Open Access Journals (Sweden)

Sultan Ayoub Meo

2013-10-01

Full Text Available Objectives: This study aimed to assess the impact of the Gross Domestic Product (GDP, spending on Research and Development (R&D, the number of universities and scientific journals on the published research documents, citable documents, citations per document and H-index in environmental sciences in the Middle East countries. Materials and Methods: All the 16 Middle East countries were included in the study. Information regarding the GDP, spending on R&D, the total number of universities and indexed journals was collected. Total number of research documents (papers, citable documents, citations per document and H-index in environmental sciences during the period 1996-2011 was recorded. The study used the World Bank, SCI-mago/Scopus, Web of Science, Journal Citation Reports (Thomson Reuters as the main sources of information. Results: The mean GDP per capita of all the Middle East countries amounted to 18 125.49±5386.28 US$, spending on R&D was 0.63±0.28 US$, the number of universities equaled 36.56±11.33 and mean ISI indexed journals amounted to 8.25±3.93. The mean number of research documents published in environmental sciences in the Middle East countries during the period 1996-2011 was 2202.12±883.98; citable documents: 2156.87±865.09; citations per document: 8.74±0.73; and the H-index: 35.37±6.17. There was a positive correlation between the money spent on R&D and citations per documents (r = 0.6, p = 0.01, H-Index (r = 0.6, p = 0.01; the number of universities and a total of research documents (r = 0.65, p = 0.006, citable documents (r = 0.65, p = 0.006, H-Index (r = 0.50, p = 0.04, as well as ISI indexed journals and total research documents (r = 0.94, p = 0.0001, citable documents (r = 0.94, p = 0.0001, H-Index (r = 0.73, p = 0.001. Conclusions: The Middle East countries which spend more on R&D and which have a large number of universities and ISI indexed journals are likely to produce more significant volume of research papers in

Impact of GDP, spending on R&D, the number of universities and scientific journals on research publications in environmental sciences in the Middle East.

Science.gov (United States)

Meo, Sultan Ayoub; Al Masri, Abeer A; Usmani, Adnan Mahmood; Halepoto, Dost Muhammad

2013-10-01

This study aimed to assess the impact of the Gross Domestic Product (GDP), spending on Research and Development (R&D), the number of universities and scientific journals on the published research documents, citable documents, citations per document and H-index in environmental sciences in the Middle East countries. All the 16 Middle East countries were included in the study. Information regarding the GDP, spending on R&D, the total number of universities and indexed journals was collected. Total number of research documents (papers), citable documents, citations per document and H-index in environmental sciences during the period 1996-2011 was recorded. The study used the World Bank, SCI-mago/Scopus, Web of Science, Journal Citation Reports (Thomson Reuters) as the main sources of information. The mean GDP per capita of all the Middle East countries amounted to 18 125.49±5386.28 US$, spending on R&D was 0.63±0.28 US$, the number of universities equaled 36.56±11.33 and mean ISI indexed journals amounted to 8.25±3.93. The mean number of research documents published in environmental sciences in the Middle East countries during the period 1996-2011 was 2202.12±883.98; citable documents: 2156.87±865.09; citations per document: 8.74±0.73; and the H-index: 35.37±6.17. There was a positive correlation between the money spent on R&D and citations per documents (r = 0.6, p = 0.01), H-Index (r = 0.6, p = 0.01); the number of universities and a total of research documents (r = 0.65, p = 0.006), citable documents (r = 0.65, p = 0.006), H-Index (r = 0.50, p = 0.04), as well as ISI indexed journals and total research documents (r = 0.94, p = 0.0001), citable documents (r = 0.94, p = 0.0001), H-Index (r = 0.73, p = 0.001). The Middle East countries which spend more on R&D and which have a large number of universities and ISI indexed journals are likely to produce more significant volume of research papers in the field of environmental science.

22 CFR 63.9 - General provisions.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false General provisions. 63.9 Section 63.9 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES PAYMENTS TO AND ON BEHALF OF PARTICIPANTS IN THE INTERNATIONAL EDUCATIONAL AND CULTURAL EXCHANGE PROGRAM § 63.9 General provisions. The following...

10 CFR 63.9 - Employee protection.

Science.gov (United States)

2010-01-01

... because the employee has engaged in protected activities. An employee's engagement in protected activities... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 63.9 Section 63.9 Energy NUCLEAR... MOUNTAIN, NEVADA General Provisions § 63.9 Employee protection. (a) Discrimination by a Commission licensee...

14 CFR 31.63 - Safety belts.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety belts. 31.63 Section 31.63 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.63 Safety belts. (a) There must be a safety belt...

7 CFR 922.63 - Effective time.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Effective time. 922.63 Section 922.63 Agriculture... IN WASHINGTON Order Regulating Handling Miscellaneous Provisions § 922.63 Effective time. The provisions of this part, and of any amendment thereto, shall become effective at such time as the Secretary...

Risk assessment of PCDD/Fs levels in human tissues related to major food items based on chemical analyses and micro-EROD assay.

Science.gov (United States)

Tsang, H L; Wu, S C; Wong, C K C; Leung, C K M; Tao, S; Wong, M H

2009-10-01

Nine groups of food items (freshwater fish, marine fish, pork, chicken, chicken eggs, leafy, non-leafy vegetables, rice and flour) and three types of human samples (human milk, maternal serum and cord serum) were collected for the analysis of PCDD/Fs. Results of chemical analysis revealed PCDD/Fs concentrations (pg g(-1) fat) in the following ascending order: pork (0.289 pg g(-1) fat), grass carp (Ctenopharyngodon idellus) (freshwater fish) (0.407), golden thread (Nemipterus virgatus) (marine fish) (0.511), chicken (0.529), mandarin fish (Siniperca kneri) (marine fish) (0.535), chicken egg (0.552), and snubnose pompano (Trachinotus blochii) (marine fish) (1.219). The results of micro-EROD assay showed relatively higher PCDD/Fs levels in fish (2.65 pg g(-1) fat) when compared with pork (0.47), eggs (0.33), chicken (0.13), flour (0.07), vegetables (0.05 pg g(-1) wet wt) and rice (0.05). The estimated average daily intake of PCDD/Fs of 3.51 pg EROD-TEQ/kg bw/day was within the range of WHO Tolerable Daily Intake (1-4 pg WHO-TEQ/kg bw/day) and was higher than the Provisional Tolerable Daily Intake (PMTL) (70 pg for dioxins and dioxin-like PCBs) recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) [Joint FAO/WHO Expert Committee on Food Additives (JECFA), Summary and conclusions of the fifty-seventh meeting, JECFA, 2001.]. Nevertheless, the current findings were significantly lower than the TDI (14 pg WHO-TEQ/kg/bw/day) recommended by the Scientific Committee on Food of the Europe Commission [European Scientific Committee on Food (EU SCF), Opinions on the SCF on the risk assessment of dioxins and dioxin-like PCBs in food, 2000.]. However, it should be noted that micro-EROD assay overestimates the PCDD/Fs levels by 2 to 7 folds which may also amplify the PCDD/Fs levels accordingly. Although the levels of PCDD/Fs obtained from micro-EROD assay were much higher than those obtained by chemical analysis by 2 to 7 folds, it provides a cost-effective and

Gaining Comparative Advantage Through Discretionary Expenditures: The Returns to R&D and Advertising

OpenAIRE

Gary Erickson; Robert Jacobson

1992-01-01

We explore the extent to which R&D and advertising expenditures generate a comparative advantage that allows firms to earn supranormal profits. After controlling for unobserved firm-specific factors and the feedback between discretionary expenditures and profitability, our results suggest substantially lower accounting and stock market returns to R&D and advertising than indicated in previous research. Isolating mechanisms, which prevent imitation, do not appear sufficient for either R&D or a...

File list: InP.Lar.50.AllAg.3rd_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available InP.Lar.50.AllAg.3rd_instar dm3 Input control Larvae 3rd instar SRX287726,SRX331369...87917,SRX287921,SRX288023,SRX467107,SRX016172,SRX016173 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Lar.50.AllAg.3rd_instar.bed ...

34 CFR 361.63 - Program income.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Program income. 361.63 Section 361.63 Education... State Vocational Rehabilitation Programs § 361.63 Program income. (a) Definition. For purposes of this section, program income means gross income received by the State that is directly generated by an activity...

7 CFR 915.63 - Effective time.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Effective time. 915.63 Section 915.63 Agriculture... Regulating Handling Miscellaneous Provisions § 915.63 Effective time. The provisions of this part shall become effective at such time as the Secretary may declare above his signature to this part, and shall...

7 CFR 923.63 - Effective time.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Effective time. 923.63 Section 923.63 Agriculture... COUNTIES IN WASHINGTON Order Regulating Handling Miscellaneous Provisions § 923.63 Effective time. The provisions of this part, and of any amendment thereto, shall become effective at such time as the Secretary...

8 CFR 240.63 - Application process.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Application process. 240.63 Section 240.63 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE... Cancellation of Removal Under Section 203 of Pub. L. 105-100 § 240.63 Application process. (a) Form and fees...

Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles

Directory of Open Access Journals (Sweden)

Yoshinao Kubo

2017-08-01

Full Text Available CD63, a member of the tetraspanin family, is involved in virion production by human immunodeficiency virus type 1 (HIV-1, but its mechanism is unknown. In this study, we showed that a small GTP-binding protein, Rab3a, interacts with CD63. When Rab3a was exogenously expressed, the amounts of CD63 decreased in cells. The Rab3a-mediated reduction of CD63 was suppressed by lysosomal and proteasomal inhibitors. The amount of CD63 was increased by reducing the endogenous Rab3a level using a specific shRNA. These results indicate that Rab3a binds to CD63 to induce the degradation of CD63. Rab3a is thought to be involved in exocytosis, but we found that another function of Rab3a affects the fate of CD63 in lysosomes. CD63 interacted with Rab3a and was incorporated into HIV-1 particles. However, Rab3a was not detected in HIV-1 virions, thereby indicating that Rab3a-free CD63, but not Rab3a-bound CD63, is incorporated into HIV-1 particles. Overexpression or silencing of Rab3a moderately reduced HIV-1 virion formation. Overexpression of Rab3a decreased CD63 levels, but did not affect the incorporation of CD63 into HIV-1 particles. This study showed that Rab3a binds to CD63 to induce the degradation of CD63, and only Rab3a-free CD63 is incorporated into HIV-1 particles.