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Sample records for jaak mll irita

  1. Kõrghariduse tulevik / Jaak Aaviksoo

    Index Scriptorium Estoniae

    Aaviksoo, Jaak, 1954-

    2001-01-01

    Teaduseelarveks 50 miljonit dollarit ning 100 doktorikraadi kaitsmist aastas on kaks korda rohkem kui kogu Eesti tänane ressurss. Tartu Ülikooli rektor Jaak Aaviksoo seab selle ülikooli 10 aasta sihiks

  2. Jaak Kilmi "Inimkaamera" sai peaauhinna

    Index Scriptorium Estoniae

    2000-01-01

    Alternatiivfilmide festivalil "Pulss" sai peaauhinna Jaak Kilmi film "Inimkaamera", huumori eripreemia Andres Maimiku ja kollektiivi Suits filmid ja novaatorluse ning originaalsuse eest auhinnati kahte Asko Kase filmi

  3. Archaeological excavations on the iron-smelting site in Tõdva village / Mauri Kiudsoo, Jaak Mäll, Irita Kallis

    Index Scriptorium Estoniae

    Kiudsoo, Mauri, 1973-

    2009-01-01

    Tõdva rauasulatuskompleksi puhul on tegemist esimese uuritud viikingiaegse rauasulatusakohaga Eestis. Uudseks võib pidada šlakianalüüsidel baseeruvat avastust, et tõenäoliselt tunti peale soomaagi ka meretekkelisi raua-mangaanikonkretsioone

  4. Jaak Prints: näitleja hirmud on üldinimlikud / Jaak Prints ; intervjueerinud Tiiu Laks

    Index Scriptorium Estoniae

    Prints, Jaak, 1981-

    2010-01-01

    Teatri NO99 näitleja Jaak Prints endast, näitlejaks olemisest, mõistest "mõtlev teater", koduteatrist, NO99 aktsioonist "Ühtne Eesti suurkogu", lavastamise soovist jm. Loetletud Jaak Printsi rollid ja tööd lavastajana

  5. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

    Science.gov (United States)

    Grembecka, Jolanta; He, Shihan; Shi, Aibin; Purohit, Trupta; Muntean, Andrew G; Sorenson, Roderick J; Showalter, Hollis D; Murai, Marcelo J; Belcher, Amalia M; Hartley, Thomas; Hess, Jay L; Cierpicki, Tomasz

    2012-01-29

    Translocations involving the mixed lineage leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interaction with menin, a product of the multiple endocrine neoplasia (MEN1) gene. Here we present what are to our knowledge the first small-molecule inhibitors of the menin-MLL fusion protein interaction that specifically bind menin with nanomolar affinities. These compounds effectively reverse MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. They also selectively block proliferation and induce both apoptosis and differentiation of leukemia cells harboring MLL translocations. Identification of these compounds provides a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of menin as an oncogenic cofactor of MLL fusion proteins. Our findings also highlight a new therapeutic strategy for aggressive leukemias with MLL rearrangements.

  6. Mll5 is required for normal spermatogenesis.

    Directory of Open Access Journals (Sweden)

    Damian B Yap

    Full Text Available Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that Mll5 is required for proper haematopoietic stem cell differentiation, and loss of Mll5 results in synthetic lethality for genome de-methylation. Mll5 deficient male mice are infertile and here we analyse the consequences of Mll5 deficiency for spermatogenesis.Mll5 deficient male mice, but not female mice, are infertile. Here we show using RNA in-situ hybridization that Mll5 is expressed in the germ cells of the testes of wild type mice. Consistent with the expression of Mll5, we demonstrate by electron microscopy, video microscopy and in vitro fertilisation techniques that Mll5 deficient mice have defects in terminal maturation and packaging of sperm. The defects seen include detachment of the acrosomal cap and impaired excess cytoplasm removal. Functional tests of sperm motility show a lack of progressive motility of spermatozoa from Mll5 deficient animals. None of these defects could be rescued by in vitro fertilization. Using microarray analysis we show that transcripts implicated in spermatogenesis are dysregulated.Our data demonstrate a clear role of Mll5 in mammalian spermatogenesis at the level of terminal differentiation providing further support for its classification in the SET3 branch of proteins. Moreover, this study identifies Tlk2, Utx, Gpr64, Sult4a1, Rap2ip, Vstm2 and HoxA10 as possible Mll5 targets that together may account for the observed spermatozoa maturation defects.

  7. Jaak Aaviksoo : Oborona i obrazovanije tak pohhozhi... / Jaak Aaviksoo ; interv. Jevgenija Garanzha

    Index Scriptorium Estoniae

    Aaviksoo, Jaak, 1954-

    2007-01-01

    Kaitseminister Jaak Aaviksoo vastab küsimustele, mis puudutavad riigi kaitsepoliitikat, uut riigikaitse plaani, Eesti-Vene suhteid, rahuvalve missioone, Kaitseliidu tegevust, ministeeriumi ja kaitseväe suhteid

  8. Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

    Index Scriptorium Estoniae

    2004-01-01

    Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

  9. Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia

    International Nuclear Information System (INIS)

    Cerveira, Nuno; Snijder, Simone; Mariz, José M; Norton, Lucília; Mellink, Clemens H; Buijs, Arjan; Teixeira, Manuel R; Santos, Joana; Bizarro, Susana; Costa, Vera; Ribeiro, Franclim R; Lisboa, Susana; Correia, Cecília; Torres, Lurdes; Vieira, Joana

    2009-01-01

    A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL-related leukemia. Recently, we have established the MLL-SEPT2 gene fusion as the molecular abnormality subjacent to the translocation t(2;11)(q37;q23) in therapy-related acute myeloid leukemia. In this work we quantified MLL and SEPT2 gene expression in 58 acute myeloid leukemia patients selected to represent the major AML genetic subgroups, as well as in all three cases of MLL-SEPT2-associated myeloid neoplasms so far described in the literature. Cytogenetics, fluorescence in situ hybridization (FISH) and molecular studies (RT-PCR, qRT-PCR and qMSP) were used to characterize 58 acute myeloid leukemia patients (AML) at diagnosis selected to represent the major AML genetic subgroups: CBFB-MYH11 (n = 13), PML-RARA (n = 12); RUNX1-RUNX1T1 (n = 12), normal karyotype (n = 11), and MLL gene fusions other than MLL-SEPT2 (n = 10). We also studied all three MLL-SEPT2 myeloid neoplasia cases reported in the literature, namely two AML patients and a t-MDS patient. When compared with normal controls, we found a 12.8-fold reduction of wild-type SEPT2 and MLL-SEPT2 combined expression in cases with the MLL-SEPT2 gene fusion (p = 0.007), which is accompanied by a 12.4-fold down-regulation of wild-type MLL and MLL-SEPT2 combined expression (p = 0.028). The down-regulation of SEPT2 in MLL-SEPT2 myeloid neoplasias was statistically significant when compared with all other leukemia genetic subgroups (including those with other MLL gene fusions). In addition, MLL expression was also down-regulated in the group of MLL fusions other than MLL-SEPT2, when compared with the normal control group (p = 0.023) We found a significant down-regulation of both SEPT2 and MLL in MLL-SEPT2 myeloid neoplasias. In addition, we also found that MLL is under-expressed in AML patients with MLL fusions other than MLL-SEPT2

  10. The MLL recombinome of acute leukemias in 2017.

    Science.gov (United States)

    Meyer, C; Burmeister, T; Gröger, D; Tsaur, G; Fechina, L; Renneville, A; Sutton, R; Venn, N C; Emerenciano, M; Pombo-de-Oliveira, M S; Barbieri Blunck, C; Almeida Lopes, B; Zuna, J; Trka, J; Ballerini, P; Lapillonne, H; De Braekeleer, M; Cazzaniga, G; Corral Abascal, L; van der Velden, V H J; Delabesse, E; Park, T S; Oh, S H; Silva, M L M; Lund-Aho, T; Juvonen, V; Moore, A S; Heidenreich, O; Vormoor, J; Zerkalenkova, E; Olshanskaya, Y; Bueno, C; Menendez, P; Teigler-Schlegel, A; Zur Stadt, U; Lentes, J; Göhring, G; Kustanovich, A; Aleinikova, O; Schäfer, B W; Kubetzko, S; Madsen, H O; Gruhn, B; Duarte, X; Gameiro, P; Lippert, E; Bidet, A; Cayuela, J M; Clappier, E; Alonso, C N; Zwaan, C M; van den Heuvel-Eibrink, M M; Izraeli, S; Trakhtenbrot, L; Archer, P; Hancock, J; Möricke, A; Alten, J; Schrappe, M; Stanulla, M; Strehl, S; Attarbaschi, A; Dworzak, M; Haas, O A; Panzer-Grümayer, R; Sedék, L; Szczepański, T; Caye, A; Suarez, L; Cavé, H; Marschalek, R

    2018-02-01

    Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.

  11. The MLL recombinome of acute leukemias in 2013

    Science.gov (United States)

    Meyer, C; Hofmann, J; Burmeister, T; Gröger, D; Park, T S; Emerenciano, M; Pombo de Oliveira, M; Renneville, A; Villarese, P; Macintyre, E; Cavé, H; Clappier, E; Mass-Malo, K; Zuna, J; Trka, J; De Braekeleer, E; De Braekeleer, M; Oh, S H; Tsaur, G; Fechina, L; van der Velden, V H J; van Dongen, J J M; Delabesse, E; Binato, R; Silva, M L M; Kustanovich, A; Aleinikova, O; Harris, M H; Lund-Aho, T; Juvonen, V; Heidenreich, O; Vormoor, J; Choi, W W L; Jarosova, M; Kolenova, A; Bueno, C; Menendez, P; Wehner, S; Eckert, C; Talmant, P; Tondeur, S; Lippert, E; Launay, E; Henry, C; Ballerini, P; Lapillone, H; Callanan, M B; Cayuela, J M; Herbaux, C; Cazzaniga, G; Kakadiya, P M; Bohlander, S; Ahlmann, M; Choi, J R; Gameiro, P; Lee, D S; Krauter, J; Cornillet-Lefebvre, P; Te Kronnie, G; Schäfer, B W; Kubetzko, S; Alonso, C N; zur Stadt, U; Sutton, R; Venn, N C; Izraeli, S; Trakhtenbrot, L; Madsen, H O; Archer, P; Hancock, J; Cerveira, N; Teixeira, M R; Lo Nigro, L; Möricke, A; Stanulla, M; Schrappe, M; Sedék, L; Szczepański, T; Zwaan, C M; Coenen, E A; van den Heuvel-Eibrink, M M; Strehl, S; Dworzak, M; Panzer-Grümayer, R; Dingermann, T; Klingebiel, T; Marschalek, R

    2013-01-01

    Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (∼90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements. PMID:23628958

  12. The MLL recombinome of acute leukemias in 2017

    NARCIS (Netherlands)

    C. Meyer; T. Burmeister; D. Gröger (D.); G. Tsaur; L. Fechina; A. Renneville; R. Sutton; N. Venn; M. Emerenciano (M.); Pombo-De-Oliveira, M.S. (M. S.); Barbieri Blunck, C. (C.); Almeida Lopes, B. (B.); J. Zuna; J. Trka (Jan); Ballerini, P. (P.); Lapillonne, H. (H.); E. de Braekeleer; G. Cazzaniga (Gianni); Corral Abascal, L. (L.); V.H.J. van der Velden (Vincent); E. Delabesse; Park, T.S. (T. S.); S.H. Oh (S.); M.L.M. Silva (M. L M); T. Lund-Aho (T.); V. Juvonen (V.); A.S. Moore (A.); O. Heidenreich; Vormoor, J. (J.); Zerkalenkova, E. (E.); Olshanskaya, Y. (Y.); Bueno, C. (C.); P. Menéndez (Pablo); A. Teigler-Schlegel; U. zur Stadt; Lentes, J. (J.); G. Göhring (Gudrun); Kustanovich, A. (A.); O. Aleinikova (O.); Schäfer, B.W. (B. W.); S. Kubetzko (S.); H.O. Madsen; Gruhn, B. (B.); Duarte, X. (X.); P. Gameiro; E. Lippert (Eric); Bidet, A. (A.); J.-M. Cayuela (Jean-Michel); E. Clappier; C.N. Alonso (Cristina); C.M. Zwaan (Christian Michel); M.M. van den Heuvel-Eibrink (Marry); S. Izraeli (Shai); L. Trakhtenbrot; P. Archer (P.); J. Hancock; A. Möricke; Alten, J. (J.); M. Schrappe (Martin); M. Stanulla (Martin); S. Strehl; A. Attarbaschi (Andishe); M.N. Dworzak (Michael); Haas, O.A. (O. A.); R. Panzer-Grümayer (Renate); L. Sedek (Lukasz); Szczepa, T. (T.); A. Caye (Aurélie); Suarez, L. (L.); H. Cavé (Helene); R. Marschalek (Rolf)

    2018-01-01

    textabstractChromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner

  13. Järve Selver = Järve Selver / Jaak Huimerind

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2000-01-01

    Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Konstruktiivne osa: Neoprojekt. I korruse avaliku tsooni värvilahendus sisearhitekt Mari Kurismaalt. Kauplused ja kontorid kujundas Tallinna Kaubamaja, toitlustuskohad\\\\ARS Interjöörprojekt. Projekt 1998-2000, valmis 2000. 9 ill.: korruste plaanid, välis- ja sisevaated

  14. Materjalid muudavad maailma = Materials change the world / Jaak Kikas

    Index Scriptorium Estoniae

    Kikas, Jaak

    2005-01-01

    Jaak Kikas TÜ materjaliteaduse instituudist mõnedest olulistest tendentsidest ja suundumustest uute materjalide otsingutel ning nendega kaasnevatest probleemidest. Materjaliteaduse artikli kommentaariks tutvustavad Kalle Komissarov (intervjueerija) ja Martin Pärn EKA disaini- ja tekstiilikateedri projekti "Arukate toodete disain - tuleviku eriala", millele saadi toetust SA Innove europrojektide raames

  15. The incidence and distribution characteristics of MLL rearrangements in Chinese acute myeloid leukemia patients by multiplex nested RT-PCR.

    Science.gov (United States)

    Yang, Hua; Cao, Tingting; Gao, Li; Wang, Lili; Zhu, Chengying; Xu, Yuanyuan; Jing, Yu; Zhu, Haiyan; Lv, Na; Yu, Li

    2017-07-20

    Occurrence of MLL (Mixed Lineage Leukemia) gene rearrangements indicates poor prognosis in acute myeloid leukemia (AML) patients. This is the first study to report the positive rate and distribution characteristics of MLL rearrangements in AML patients in north China. We used multiplex nested real time PCR (RT-PCR) to screen for incidence of 11 MLL rearrangements in 433 AML patients. Eleven MLL rearrangements included (MLL-PTD, MLL-AF9, MLL-ELL, MLL-AF10, MLL-AF17, MLL-AF6, MLL-ENL, MLL-AF1Q, MLL-CBP, MLL-AF1P, MLL-AFX1). There were 68 AML patients with MLL rearrangements, and the positive rate was 15.7%. MLL-PTD (4.84%) was detected in 21 patients, MLL-AF9 in 15, (3.46%), MLL-ELL in 10 (2.31%), MLL-AF10 in 8 (1.85%), MLL-AF1Q in 2 (0.46%), 3 cases each of MLL-AF17, MLL-AF6, MLL-ENL (0.69% each), a and single case each of MLL-CBP, MLL-AF1P, and MLL-AFX1 (0.23% each). The highest rate of MLL rearrangements was found in 24 patients with M5 subtype AML, occurring in 24 cases (35.3%). MLL rearrangements occurred in 21 patients with M2 subtype AML (30.9%), and in 10 patients with M4 subtype AML (14.7%). Screening fusion genes by multiplex nested RT-PCR is a convenient, fast, economical, and accurate method for diagnosis and predicting prognosis of AML.

  16. The MLL recombinome of acute leukemias in 2013

    DEFF Research Database (Denmark)

    Meyer, C; Hofmann, Julian; Burmeister, T

    2013-01-01

    patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79......Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia...... patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All...

  17. Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

    Directory of Open Access Journals (Sweden)

    Thomas A. Milne

    2012-09-01

    Full Text Available Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis.

  18. Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Ballabio, Erica; Milne, Thomas A., E-mail: thomas.milne@imm.ox.ac.uk [MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital Headington, Oxford OX3 9DS (United Kingdom)

    2012-09-10

    Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC) inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL) protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis.

  19. Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

    International Nuclear Information System (INIS)

    Ballabio, Erica; Milne, Thomas A.

    2012-01-01

    Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC) inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL) protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis

  20. The MLL recombinome of acute leukemias in 2017

    DEFF Research Database (Denmark)

    Meyer, C; Burmeister, T; Gröger, D

    2018-01-01

    Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs)...... of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.Leukemia advance online publication, 8 August 2017; doi:10.1038/leu.2017.213....

  1. Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene

    Science.gov (United States)

    Catalina, Purificación; Rodríguez, René; Melen, Gustavo J.; Bueno, Clara; Arriero, Mar; García-Sánchez, Félix; Lassaletta, Alvaro; García-Sanz, Ramón

    2009-01-01

    MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesis of several hematological malignances. BM mesenchymal stem cells (BM-MSC) from 38 children diagnosed with cytogenetically different acute leukemias were screened for leukemic fusion genes. Fusion genes were absent in BM-MSCs of childhood leukemias carrying TEL-AML1, BCR-ABL, AML1-ETO, MLL-AF9, MLL-AF10, MLL-ENL or hyperdiploidy. However, MLL-AF4 was detected and expressed in BM-MSCs from all cases of MLL-AF4+ B-ALL. Unlike leukemic blasts, MLL-AF4+ BM-MSCs did not display monoclonal Ig gene rearrangements. Endogenous or ectopic expression of MLL-AF4 exerted no effect on MSC culture homeostasis. These findings suggest that MSCs may be in part tumor-related, highlighting an unrecognized role of the BM milieu on the pathogenesis of MLL-AF4+ B-ALL. MLL-AF4 itself is not sufficient for MSC transformation and the expression of MLL-AF4 in MSCs is compatible with a mesenchymal phenotype, suggesting a differential impact in the hematopoietic system and mesenchyme. The absence of monoclonal rearrangements in MLL-AF4+ BM-MSCs precludes the possibility of cellular plasticity or de-differentiation of B-ALL blasts and suggests that MLL-AF4 might arise in a population of prehematopoietic precursors. PMID:19995953

  2. Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited

    Directory of Open Access Journals (Sweden)

    Sun Jian-Sheng

    2006-01-01

    Full Text Available Abstract Background Haematological cancer is characterised by chromosomal translocation (e.g. MLL translocation in acute leukaemia and two models have been proposed to explain the origins of recurrent reciprocal translocation. The first, established from pairs of translocated genes (such as BCR and ABL, considers the spatial proximity of loci in interphase nuclei (static "contact first" model. The second model is based on the dynamics of double strand break ends during repair processes (dynamic "breakage first" model. Since the MLL gene involved in 11q23 translocation has more than 40 partners, the study of the relative positions of the MLL gene with both the most frequent partner gene (AF4 and a less frequent partner gene (ENL, should elucidate the MLL translocation mechanism. Methods Using triple labeling 3D FISH experiments, we have determined the relative positions of MLL, AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines. Results In all cell lines, the ENL gene is significantly closer to the MLL gene than the AF4 gene (with P value loci would indicate a greater probability of the occurrence of t(11;19(q23;p13.3 compared to t(4;11(q21;q23. However this is in contradiction to the epidemiology of 11q23 translocation. Conclusion The simultaneous multi-probe hybridization in 3D-FISH is a new approach in addressing the correlation between spatial proximity and occurrence of translocation. Our observations are not consistent with the static "contact first" model of translocation. The recently proposed dynamic "breakage first" model offers an attractive alternative explanation.

  3. Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited

    International Nuclear Information System (INIS)

    Gué, Michaël; Sun, Jian-Sheng; Boudier, Thomas

    2006-01-01

    Haematological cancer is characterised by chromosomal translocation (e.g. MLL translocation in acute leukaemia) and two models have been proposed to explain the origins of recurrent reciprocal translocation. The first, established from pairs of translocated genes (such as BCR and ABL), considers the spatial proximity of loci in interphase nuclei (static 'contact first' model). The second model is based on the dynamics of double strand break ends during repair processes (dynamic 'breakage first' model). Since the MLL gene involved in 11q23 translocation has more than 40 partners, the study of the relative positions of the MLL gene with both the most frequent partner gene (AF4) and a less frequent partner gene (ENL), should elucidate the MLL translocation mechanism. Using triple labeling 3D FISH experiments, we have determined the relative positions of MLL, AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines. In all cell lines, the ENL gene is significantly closer to the MLL gene than the AF4 gene (with P value < 0.0001). According to the static 'contact first' model of the translocation mechanism, a minimal distance between loci would indicate a greater probability of the occurrence of t(11;19)(q23;p13.3) compared to t(4;11)(q21;q23). However this is in contradiction to the epidemiology of 11q23 translocation. The simultaneous multi-probe hybridization in 3D-FISH is a new approach in addressing the correlation between spatial proximity and occurrence of translocation. Our observations are not consistent with the static 'contact first' model of translocation. The recently proposed dynamic 'breakage first' model offers an attractive alternative explanation

  4. MLL-ENL cooperates with SCF to transform primary avian multipotent cells

    NARCIS (Netherlands)

    Schulte, Cathleen E.; von Lindern, Marieke; Steinlein, Peter; Beug, Hartmut; Wiedemann, Leanne M.

    2002-01-01

    The MLL gene is targeted by chromosomal translocations, which give rise to heterologous MLL fusion proteins and are associated with distinct types of acute lymphoid and myeloid leukaemia. To determine how MLL fusion proteins alter the proliferation and/or differentiation of primary haematopoietic

  5. Minu kogemus: Facebook kui töö- ja õppevahend / Jaak Juske

    Index Scriptorium Estoniae

    Juske, Jaak, 1976-

    2015-01-01

    Jaak Juske jaoks on FB hindamatu ühismälu kandja. Kuna ta paneb oma seinale pidevalt koos kommentaaridega üles vanu pilte, linke blogilugudele jne., siis hakkab see silma ka FB aktiivselt kasutatavatele noortele

  6. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.

    Science.gov (United States)

    Cao, Fang; Townsend, Elizabeth C; Karatas, Hacer; Xu, Jing; Li, Li; Lee, Shirley; Liu, Liu; Chen, Yong; Ouillette, Peter; Zhu, Jidong; Hess, Jay L; Atadja, Peter; Lei, Ming; Qin, Zhaohui S; Malek, Sami; Wang, Shaomeng; Dou, Yali

    2014-01-23

    Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activity by blocking MLL1-WDR5 interaction and thus the complex assembly. This targeting strategy does not affect other mixed-lineage leukemia (MLL) family histone methyltransferases (HMTs), revealing a unique regulatory feature for the MLL1 complex. Using MM-401 and its enantiomer control MM-NC-401, we show that inhibiting MLL1 methyltransferase activity specifically blocks proliferation of MLL cells by inducing cell-cycle arrest, apoptosis, and myeloid differentiation without general toxicity to normal bone marrow cells or non-MLL cells. More importantly, transcriptome analyses show that MM-401 induces changes in gene expression similar to those of MLL1 deletion, supporting a predominant role of MLL1 activity in regulating MLL1-dependent leukemia transcription program. We envision broad applications for MM-401 in basic and translational research. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Maarjamäe tallihoone äratamine = Waking of the Maarjamäe stables / Jaak Huimerind, Tarmo Piirmets ; intervjueerinud Katrin Koov

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2015-01-01

    Intervjuu arhitekt Jaak Huimerinnaga ja sisearhitekt Tarmo Piirmetsaga Maarjamäe suvemõisa tallihoone restaureerimisest, millest sai Eesti Ajaloomuuseumi näitusteruum. Arhitektuur: Jaak Huimerind, Kadri Viltrop, Stuudio Paralleel. Sisearhitektuur: Tarmo Piirmets, PINK. Valmimisaasta: 2014

  8. Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.

    Science.gov (United States)

    Wang, Zhi-Hui; Li, Dong-Dong; Chen, Wei-Lin; You, Qi-Dong; Guo, Xiao-Ke

    2018-01-15

    The mixed lineage leukemia protein-1 (MLL1), as a lysine methyltransferase, predominantly regulates the methylation of histone H3 lysine 4 (H3K4) and functions in hematopoietic stem cell (HSC) self-renewal. MLL1 gene fuses with partner genes that results in the generation of MLL1 fusion proteins (MLL1-FPs), which are frequently detected in acute leukemia. In the progress of leukemogenesis, a great deal of proteins cooperate with MLL1 to form multiprotein complexes serving for the dysregulation of H3K4 methylation, the overexpression of homeobox (HOX) cluster genes, and the consequent generation of leukemia. Hence, disrupting the interactions between MLL1 and the reciprocal proteins has been considered to be a new treatment strategy for leukemia. Here, we reviewed potential protein-protein interactions (PPIs) between MLL1 and its reciprocal proteins, and summarized the inhibitors to target MLL1 PPIs. The druggability of MLL1 PPIs for leukemia were also discussed. Copyright © 2017. Published by Elsevier Ltd.

  9. Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL

    International Nuclear Information System (INIS)

    Do, To Uyen; Ho, Bay; Shih, Shyh-Jen; Vaughan, Andrew

    2012-01-01

    Highlights: ► A Zinc Finger Nuclease (ZFN) targeting a leukemogenic hot spot for rearrangement in MLL is created. ► The novel ZFN efficiently cleaves MLL exon 13. ► Despite MLL cleavage and evidence of mis-repair, no leukemogenic translocations were produced. ► MLL cleavage alone is insufficient to generate leukemogenic translocations. - Abstract: Radiation treatment or chemotherapy has been linked with a higher risk of secondary cancers such as therapy related Acute Myeloid Leukemia (tAML). Several of these cancers have been shown to be correlated to the introduction of double stranded breaks (DSB) and rearrangements within the Mixed Lineage Leukemia (MLL) gene. We used Zinc Finger Nucleases (ZFNs) to introduce precise cuts within MLL to examine how a single DNA DSB might lead to chromosomal rearrangements. A ZFN targeting exon 13 within the Breakpoint Cluster Region of MLL was transiently expressed in a human lymphoblast cell line originating from a CML patient. Although FISH analysis showed ZFN DSB at this region increased the rate of MLL fragmentation, we were unable to detect leukemogenic rearrangements or translocations via inverse PCR. Interestingly, gene fragmentation as well as small interstitial deletions, insertions and base substitutions increased with the inhibition of DNA-PK, suggesting repair of this particular DSB is linked to non-homologous end joining (NHEJ). Although mis-repair of DSBs may be necessary for the initiation of leukemogenic translocations, a MLL targeted DNA break alone is insufficient

  10. Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL

    Energy Technology Data Exchange (ETDEWEB)

    Do, To Uyen [Graduate Group in Immunology, University of California Davis, Davis, CA 95616 (United States); Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States); Ho, Bay; Shih, Shyh-Jen [Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States); Vaughan, Andrew, E-mail: Andrew.vaughan@ucdmc.ucdavis.edu [Graduate Group in Immunology, University of California Davis, Davis, CA 95616 (United States); Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States)

    2012-12-15

    Highlights: ► A Zinc Finger Nuclease (ZFN) targeting a leukemogenic hot spot for rearrangement in MLL is created. ► The novel ZFN efficiently cleaves MLL exon 13. ► Despite MLL cleavage and evidence of mis-repair, no leukemogenic translocations were produced. ► MLL cleavage alone is insufficient to generate leukemogenic translocations. - Abstract: Radiation treatment or chemotherapy has been linked with a higher risk of secondary cancers such as therapy related Acute Myeloid Leukemia (tAML). Several of these cancers have been shown to be correlated to the introduction of double stranded breaks (DSB) and rearrangements within the Mixed Lineage Leukemia (MLL) gene. We used Zinc Finger Nucleases (ZFNs) to introduce precise cuts within MLL to examine how a single DNA DSB might lead to chromosomal rearrangements. A ZFN targeting exon 13 within the Breakpoint Cluster Region of MLL was transiently expressed in a human lymphoblast cell line originating from a CML patient. Although FISH analysis showed ZFN DSB at this region increased the rate of MLL fragmentation, we were unable to detect leukemogenic rearrangements or translocations via inverse PCR. Interestingly, gene fragmentation as well as small interstitial deletions, insertions and base substitutions increased with the inhibition of DNA-PK, suggesting repair of this particular DSB is linked to non-homologous end joining (NHEJ). Although mis-repair of DSBs may be necessary for the initiation of leukemogenic translocations, a MLL targeted DNA break alone is insufficient.

  11. MLL2 mutation detection in 86 patients with Kabuki syndrome: a genotype-phenotype study.

    Science.gov (United States)

    Makrythanasis, P; van Bon, B W; Steehouwer, M; Rodríguez-Santiago, B; Simpson, M; Dias, P; Anderlid, B M; Arts, P; Bhat, M; Augello, B; Biamino, E; Bongers, E M H F; Del Campo, M; Cordeiro, I; Cueto-González, A M; Cuscó, I; Deshpande, C; Frysira, E; Izatt, L; Flores, R; Galán, E; Gener, B; Gilissen, C; Granneman, S M; Hoyer, J; Yntema, H G; Kets, C M; Koolen, D A; Marcelis, C l; Medeira, A; Micale, L; Mohammed, S; de Munnik, S A; Nordgren, A; Psoni, S; Reardon, W; Revencu, N; Roscioli, T; Ruiterkamp-Versteeg, M; Santos, H G; Schoumans, J; Schuurs-Hoeijmakers, J H M; Silengo, M C; Toledo, L; Vendrell, T; van der Burgt, I; van Lier, B; Zweier, C; Reymond, A; Trembath, R C; Perez-Jurado, L; Dupont, J; de Vries, B B A; Brunner, H G; Veltman, J A; Merla, G; Antonarakis, S E; Hoischen, A

    2013-12-01

    Recently, pathogenic variants in the MLL2 gene were identified as the most common cause of Kabuki (Niikawa-Kuroki) syndrome (MIM#147920). To further elucidate the genotype-phenotype correlation, we studied a large cohort of 86 clinically defined patients with Kabuki syndrome (KS) for mutations in MLL2. All patients were assessed using a standardized phenotype list and all were scored using a newly developed clinical score list for KS (MLL2-Kabuki score 0-10). Sequencing of the full coding region and intron-exon boundaries of MLL2 identified a total of 45 likely pathogenic mutations (52%): 31 nonsense, 10 missense and four splice-site mutations, 34 of which were novel. In five additional patients, novel, i.e. non-dbSNP132 variants of clinically unknown relevance, were identified. Patients with likely pathogenic nonsense or missense MLL2 mutations were usually more severely affected (median 'MLL2-Kabuki score' of 6) as compared to the patients without MLL2 mutations (median 'MLL2-Kabuki score' of 5), a significant difference (p < 0.0014). Several typical facial features such as large dysplastic ears, arched eyebrows with sparse lateral third, blue sclerae, a flat nasal tip with a broad nasal root, and a thin upper and a full lower lip were observed more often in mutation positive patients. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

    Directory of Open Access Journals (Sweden)

    Bibhu P. Mishra

    2014-05-01

    Full Text Available Despite correlations between histone methyltransferase (HMT activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4 methyltransferase critical for maintaining hematopoietic stem cells (HSCs. Here, we show that the SET domain, and thus HMT activity of MLL1, is dispensable for maintaining HSCs and supporting leukemogenesis driven by the MLL-AF9 fusion oncoprotein. Upon Mll1 deletion, histone H4 lysine 16 (H4K16 acetylation is selectively depleted at MLL1 target genes in conjunction with reduced transcription. Surprisingly, inhibition of SIRT1 is sufficient to prevent the loss of H4K16 acetylation and the reduction in MLL1 target gene expression. Thus, recruited MOF activity, and not the intrinsic HMT activity of MLL1, is central for the maintenance of HSC target genes. In addition, this work reveals a role for SIRT1 in opposing MLL1 function.

  13. Initiation of MLL-rearranged AML is dependent on C/EBPα

    DEFF Research Database (Denmark)

    Ohlsson, Ewa; Hasemann, Marie Sigurd; Willer, Anton

    2014-01-01

    have compared gene expression profiles from human MLL-rearranged AML to normal progenitors and identified the myeloid tumor suppressor C/EBPα as a putative collaborator in MLL-rearranged AML. Interestingly, we find that deletion of Cebpa rendered murine hematopoietic progenitors completely resistant...

  14. HOXA9 is required for survival in human MLL-rearranged acute leukemias

    NARCIS (Netherlands)

    J. Faber (Joerg); A.V. Krivtsov (Andrei); M.C. Stubbs (Matthew); R. Wright (Renee); T.N. Davis (Tina); M.M. van den Heuvel-Eibrink (Marry); C.M. Zwaan (Christian Michel); A.L. Kung (Andrew); S.A. Armstrong (Scott)

    2009-01-01

    textabstractLeukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression

  15. Science of the Brain as a Gateway to Understanding Play: An Interview with Jaak Panksepp

    Science.gov (United States)

    American Journal of Play, 2010

    2010-01-01

    Jaak Panksepp, known best for his work on animal emotions and coining the term "affective neuroscience," investigates the primary processes of brain and mind that enable and drive emotion. As an undergraduate, he briefly considered a career in electrical engineering but turned instead to psychology, which led to a 1969 University of…

  16. Morel-Lavallee Lesion (MLL) Mimicking A Soft Tissue Neoplasm.

    Science.gov (United States)

    Kumar, Sandeep; Hasan, Roumina; Kadavigere, Rajagopal; Maddukuri, Satish Babu; Puppala, Radha

    2015-04-01

    Morel-lavallee lesion (MLL) represents post traumatic subcutaneous cyst generally overlying bony prominences like greater trochanter, lower back, knee and scapula. A 51-year-old man presented with a swelling in left thigh since six years which was insidious in onset, gradually progressive in size and not associated with pain, fever or discharge. There was no history of trauma or any associated constitutional symptoms. Since there was no history of trauma recalled by the patient the clinical dilemma was between soft tissue sarcoma and cold abscess. We report a case of slow growing painless mass lesion of thigh, diagnosed on Magnetic Resonance Imaging (MRI) as morel lavallee lesion and describe its salient imaging features with treatment options.

  17. MLL-ENL cooperates with SCF to transform primary avian multipotent cells.

    Science.gov (United States)

    Schulte, Cathleen E; von Lindern, Marieke; Steinlein, Peter; Beug, Hartmut; Wiedemann, Leanne M

    2002-08-15

    The MLL gene is targeted by chromosomal translocations, which give rise to heterologous MLL fusion proteins and are associated with distinct types of acute lymphoid and myeloid leukaemia. To determine how MLL fusion proteins alter the proliferation and/or differentiation of primary haematopoietic progenitors, we introduced the MLL-AF9 and MLL-ENL fusion proteins into primary chicken bone marrow cells. Both fusion proteins caused the sustained outgrowth of immature haematopoietic cells, which was strictly dependent on stem cell factor (SCF). The renewing cells have a long in vitro lifespan exceeding the Hayflick limit of avian cells. Analysis of clonal cultures identified the renewing cells as immature, multipotent progenitors, expressing erythroid, myeloid, lymphoid and stem cell surface markers. Employing a two-step commitment/differentiation protocol involving the controlled withdrawal of SCF, the MLL-ENL-transformed progenitors could be induced to terminal erythroid or myeloid differentiation. Finally, in cooperation with the weakly leukaemogenic receptor tyrosine kinase v-Sea, the MLL-ENL fusion protein gave rise to multilineage leukaemia in chicks, suggesting that other activated, receptor tyrosine kinases can substitute for ligand-activated c-Kit in vivo.

  18. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Yoshiyuki Watanabe

    Full Text Available MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study.We analyzed mutations of coding region and promoter methylation in MLL3 using 126 cases of colorectal cancer. We found two isoforms of MLL3 and DNA sequencing revealed frameshift and other mutations affecting both isoforms of MLL3 in colorectal cancer cells and 19 of 134 (14% primary colorectal samples analyzed. Moreover, frameshift mutations were more common in cases with microsatellite instability (31% both in CRC cell lines and primary tumors. The largest isoform of MLL3 is transcribed from a CpG island-associated promoter that has highly homology with a pseudo-gene on chromosome 22 (psiTPTE22. Using an assay which measured both loci simultaneously we found prominent age related methylation in normal colon (from 21% in individuals less than 25 years old to 56% in individuals older than 70, R = 0.88, p<0.001 and frequent hypermethylation (83% in both CRC cell lines and primary tumors. We next studied the two loci separately and found that age and cancer related methylation was solely a property of the pseudogene CpG island and that the MLL3 loci was unmethylated.We found that frameshift mutations of MLL3 in both CRC cells and primary tumor that were more common in cases with microsatellite instability. Moreover, we have shown CpG island-associated promoter of MLL3 gene has no DNA methylation in CRC cells but also primary tumor and normal colon, and this region has a highly homologous of pseudo gene (psiTPTE22 that was age relate DNA methylation.

  19. Rahumaa ja Raid ehitavad Balti riikide suurimat tööstuskontserni / Indrek Rahumaa, Jaak Raid ; interv. Mikk Salu

    Index Scriptorium Estoniae

    Rahumaa, Indrek, 1972-

    2007-01-01

    Kalevi kompvekivabriku ja Tere piimatööstuse uued omanikud Indrek Rahumaa ja Jaak Raid vastavad küsimustele, mis puudutavad nende edasisi äri- ja investeeringuplaane. Vt. samas: Alta Capital Partners S.C.A.

  20. MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.

    Science.gov (United States)

    Mater, David Van; Goodman, Barbara K; Wang, Endi; Gaca, Ana M; Wechsler, Daniel S

    2012-04-01

    Lymphoblastic lymphoma is the second most common type of non-Hodgkin lymphoma seen in children. Approximately, 90% of lymphoblastic lymphomas arise from T cells, with the remaining 10% being B-cell-lineage derived. Although T-cell lymphoblastic lymphoma most frequently occurs in the anterior mediastinum (thymus), B-cell lymphoblastic lymphoma (B-LBL) predominates in extranodal sites such as skin and bone. Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. MLL duplication/amplification has been described primarily in acute myeloid leukemia and myelodysplastic syndrome with no published reports of discrete MLL duplication/amplification events in B-LBL. The MLL gene duplication noted in this case may represent a novel mechanism for tumorigenesis in B-LBL.

  1. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Jing; Gurung, Buddha; Wan, Bingbing; Matkar, Smita; Veniaminova, Natalia A.; Wan, Ke; Merchant, Juanita L.; Hua, Xianxin; Lei, Ming (Michigan); (Michigan-Med); (UPENN-MED)

    2013-04-08

    Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is characterized by tumorigenesis in multiple endocrine organs. Menin interacts with many proteins and is involved in a variety of cellular processes. Menin binds the JUN family transcription factor JUND and inhibits its transcriptional activity. Several MEN1 missense mutations disrupt the menin-JUND interaction, suggesting a correlation between the tumour-suppressor function of menin and its suppression of JUND-activated transcription. Menin also interacts with mixed lineage leukaemia protein 1 (MLL1), a histone H3 lysine 4 methyltransferase, and functions as an oncogenic cofactor to upregulate gene transcription and promote MLL1-fusion-protein-induced leukaemogenesis. A recent report on the tethering of MLL1 to chromatin binding factor lens epithelium-derived growth factor (LEDGF) by menin indicates that menin is a molecular adaptor coordinating the functions of multiple proteins. Despite its importance, how menin interacts with many distinct partners and regulates their functions remains poorly understood. Here we present the crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer. These structures show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but that it can have opposite effects on transcription. The menin-JUND interaction blocks JUN N-terminal kinase (JNK)-mediated JUND phosphorylation and suppresses JUND-induced transcription. In contrast, menin promotes gene transcription by binding the transcription activator MLL1 through the peptide pocket while still interacting with the chromatin-anchoring protein LEDGF at a distinct surface formed by both menin and MLL1.

  2. Zehn Oden / Kristjan Jaak Peterson ; [Deutsch von Gisbert Jänicke

    Index Scriptorium Estoniae

    Peterson, Kristian Jaak, 1801-1822

    2001-01-01

    On ilmunud ka kogumikus "Iaak. Kristian Jaak Peterson 200" (Tln. : Eesti Keele Sihtasutus, 2001, lk. 105-122). Sisu: Der Mond = Kuu ; Freundschaft = Sõprus ; Der Sänger = Laulja ; An Gott = Jumalale ; Hoffnung = Lootus ; Ich muss Trinken. Liedchen = Ma pean jooma. Lauluke ; Ich bin wieder glücklich = Olen jälle õnnis ; Der Mensch = Inimene ; Sonnenuntergang = Päeva loojaminemine ; Herbst = Sügise.

  3. Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia

    Czech Academy of Sciences Publication Activity Database

    Čermáková, K.; Těšina, Petr; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Řezáčová, Pavlína; Veverka, Václav; De Rijck, J.

    2014-01-01

    Roč. 74, č. 18 (2014), s. 5139-5151 ISSN 0008-5472 R&D Projects: GA MŠk(CZ) LK11205; GA MŠk(CZ) 7E08066; GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : MLL * leukemia * LEDGF/p75 Subject RIV: CE - Biochemistry Impact factor: 9.329, year: 2014

  4. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.

    Science.gov (United States)

    Herz, Hans-Martin; Mohan, Man; Garruss, Alexander S; Liang, Kaiwei; Takahashi, Yoh-Hei; Mickey, Kristen; Voets, Olaf; Verrijzer, C Peter; Shilatifard, Ali

    2012-12-01

    Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancers. Although in yeast all H3K4 methylation patterns, including H3K4me1, are implemented by Set1/COMPASS (complex of proteins associated with Set1), there are three classes of COMPASS-like complexes in Drosophila that could carry out H3K4me1 on enhancers: dSet1, Trithorax, and Trithorax-related (Trr). Here, we report that Trr, the Drosophila homolog of the mammalian Mll3/4 COMPASS-like complexes, can function as a major H3K4 monomethyltransferase on enhancers in vivo. Loss of Trr results in a global decrease of H3K4me1 and H3K27ac levels in various tissues. Assays with the cut wing margin enhancer implied a functional role for Trr in enhancer-mediated processes. A genome-wide analysis demonstrated that Trr is required to maintain the H3K4me1 and H3K27ac chromatin signature that resembles the histone modification patterns described for enhancers. Furthermore, studies in the mammalian system suggested a role for the Trr homolog Mll3 in similar processes. Since Trr and mammalian Mll3/4 complexes are distinguished by bearing a unique subunit, the H3K27 demethylase UTX, we propose a model in which the H3K4 monomethyltransferases Trr/Mll3/Mll4 and the H3K27 demethylase UTX cooperate to regulate the transition from inactive/poised to active enhancers.

  5. Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

    Science.gov (United States)

    Aoki, Yuki; Watanabe, Takashi; Saito, Yoriko; Kuroki, Yoko; Hijikata, Atsushi; Takagi, Masatoshi; Tomizawa, Daisuke; Eguchi, Mariko; Eguchi-Ishimae, Minenori; Kaneko, Akiko; Ono, Rintaro; Sato, Kaori; Suzuki, Nahoko; Fujiki, Saera; Koh, Katsuyoshi; Ishii, Eiichi; Shultz, Leonard D.; Ohara, Osamu; Mizutani, Shuki

    2015-01-01

    Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34+CD38+CD19+ and CD34−CD19+ cells initiated leukemia, and in MLL-AF9 patients, CD34−CD19+ cells were LICs. In MLL-ENL patients, either CD34+ or CD34− cells were LICs, depending on the pattern of CD34 expression. In contrast, in patients with these MLL translocations, CD34+CD38−CD19−CD33− cells were enriched for normal hematopoietic stem cells (HSCs) with in vivo long-term multilineage hematopoietic repopulation capacity. Although LICs developed leukemic cells with clonal immunoglobulin heavy-chain (IGH) rearrangement in vivo, CD34+CD38−CD19−CD33− cells repopulated recipient bone marrow and spleen with B cells, showing broad polyclonal IGH rearrangement and recipient thymus with CD4+ single positive (SP), CD8+ SP, and CD4+CD8+ double-positive (DP) T cells. Global gene expression profiling revealed that CD9, CD32, and CD24 were over-represented in MLL-AF4, MLL-AF9, and MLL-ENL LICs compared with normal HSCs. In patient samples, these molecules were expressed in CD34+CD38+ and CD34− LICs but not in CD34+CD38−CD19−CD33− HSCs. Identification of LICs and LIC-specific molecules in primary human MLL-rearranged acute lymphoblastic leukemia may lead to improved therapeutic strategies for MLL-rearranged leukemia. PMID:25538041

  6. TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

    DEFF Research Database (Denmark)

    Willer, Anton; Jakobsen, Janus Schou; Ohlsson, E

    2015-01-01

    orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid leukemia (AML). TGIF1/TGIF2 are relatively uncharacterized TALE transcription factors, which, in contrast to the remaining family, have been shown to act as transcriptional repressors. Given the general......Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which...... influence the clinical outcome. Collectively, these findings demonstrate that TALE family members can act both positively and negatively on transcriptional programs responsible for leukemic maintenance and provide novel insights into the regulatory gene expression circuitries in MLL-rearranged AML.Leukemia...

  7. MLL/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly during Mitosis.

    Science.gov (United States)

    Ali, Aamir; Veeranki, Sailaja Naga; Chinchole, Akash; Tyagi, Shweta

    2017-06-19

    Mixed-lineage leukemia (MLL), along with multisubunit (WDR5, RbBP5, ASH2L, and DPY30) complex catalyzes the trimethylation of H3K4, leading to gene activation. Here, we characterize a chromatin-independent role for MLL during mitosis. MLL and WDR5 localize to the mitotic spindle apparatus, and loss of function of MLL complex by RNAi results in defects in chromosome congression and compromised spindle formation. We report interaction of MLL complex with several kinesin and dynein motors. We further show that the MLL complex associates with Kif2A, a member of the Kinesin-13 family of microtubule depolymerase, and regulates the spindle localization of Kif2A during mitosis. We have identified a conserved WDR5 interaction (Win) motif, so far unique to the MLL family, in Kif2A. The Win motif of Kif2A engages in direct interactions with WDR5 for its spindle localization. Our findings highlight a non-canonical mitotic function of MLL complex, which may have a direct impact on chromosomal stability, frequently compromised in cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

    Directory of Open Access Journals (Sweden)

    Raquel Levón Herrera

    2000-04-01

    Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

  9. Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

    African Journals Online (AJOL)

    Background: Variations in disease presentation and outcome of leukemia treatment has been associated with the presence of certain mutant genes. Three major translocations (ETV6‑RUNX1, BCR‑ABL, and AF4‑MLL) in acute lymphoblastic leukemia (ALL) have been shown to affect treatment outcome. This study is aimed ...

  10. An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.

    Science.gov (United States)

    Rickels, Ryan; Hu, Deqing; Collings, Clayton K; Woodfin, Ashley R; Piunti, Andrea; Mohan, Man; Herz, Hans-Martin; Kvon, Evgeny; Shilatifard, Ali

    2016-07-21

    Polycomb response elements (PREs) are specific DNA sequences that stably maintain the developmental pattern of gene expression. Drosophila PREs are well characterized, whereas the existence of PREs in mammals remains debated. Accumulating evidence supports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of CGIs is selected to serve as PREs is unclear. Trithorax (Trx) positively regulates gene expression in Drosophila and co-occupies PREs to antagonize Polycomb-dependent silencing. Here we demonstrate that Trx-dependent H3K4 dimethylation (H3K4me2) marks Drosophila PREs and maintains the developmental expression pattern of nearby genes. Similarly, the mammalian Trx homolog, MLL1, deposits H3K4me2 at CpG-dense regions that could serve as PREs. In the absence of MLL1 and H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these loci. By inhibiting PRC2-dependent H3K27me3 in the absence of MLL1, we can rescue expression of these loci, demonstrating a functional balance between MLL1 and PRC2 activities at these sites. Thus, our study provides rules for identifying cell-type-specific functional mammalian PREs within the human genome. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

    African Journals Online (AJOL)

    2015-05-12

    May 12, 2015 ... features of prognostic importance, which include total white blood cell count (P = 0.416) and FAB subtype (P = 0.576). Conclusion: Presence of fusion ... Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR/ABL fusion ... define distinct clinic‑pathological subgroups and have been used in risk ...

  12. MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.

    NARCIS (Netherlands)

    Horton, S.J.; Jaques, J.; Woolthuis, C.; Dijk, J. van; Mesuraca, M.; Huls, G.A.; Morrone, G.; Vellenga, E.; Schuringa, J.J.

    2013-01-01

    The MLL-AF9 fusion gene is associated with aggressive leukemias of both the myeloid and lymphoid lineage in infants, whereas in adults, this translocation is mainly associated with acute myeloid leukemia. These observations suggest that differences exist between fetal and adult tissues in terms of

  13. Uued CO₂ kasukad vanadele majadele / Elari Udam ; intervjueerinud Margit Mutso ; kommenteerinud Peeter Pere, Oliver Orro, Jaak Huimerind

    Index Scriptorium Estoniae

    Udam, Elari, 1968-

    2011-01-01

    Vabade CO₂ kvootide müügist laekunud raha eest renoveeritakse energiatõhusaks 480 Eesti hoonet. Projekti juhib Riigi Kinnisvara AS. Teemat selgitab RKASi juhatuse liige ja haldusdirektor Elari Udam, kommenteerivad Eesti Arhitektide Liidu esimees Peeter Pere, aseesimees Jaak Huimerind ja arhitektuuriajaloolane Oliver Orro

  14. Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

    Science.gov (United States)

    Schröter, David; Matthews, Helen C.; Bogani, Debora; Moir, Lee; Long, Anna; Church, Christopher; Hugill, Alison; Anstee, Quentin M.; Goldin, Rob; Thursz, Mark; Hollfelder, Florian; Cox, Roger D.

    2013-01-01

    We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes) died during embryonic development at 9.5–14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level. PMID:23826075

  15. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

    Directory of Open Access Journals (Sweden)

    Michelle Goldsworthy

    Full Text Available We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7 gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes died during embryonic development at 9.5-14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level.

  16. Teater - isiklikud või ühised asjad / Monika Läänesaar, Jaak Allik, Toomas Lõhmuste ; interv. Madis Kolk

    Index Scriptorium Estoniae

    Läänesaar, Monika

    2008-01-01

    Vestlusringis kõnelevad 2007. aasta lõpul Tel Avivis toimunud Iisraeli draamafestivalist "Isra-Drama" Monika Läänesaar, Jaak Allik ja Toomas Lõhmuste. Festival tutvustab uut Iisraeli dramaturgiat, mis on tõlgitud inglise keelde

  17. Eesti Ajaloomuuseumi, Maarjamäe lossi tallihoone renoveerimine = Renovation of the Estonian History Museum's Maarjamäe palace stables / Jaak Huimerind, Tarmo Piirmets ; kommenteerinud Kaido Kivi

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2015-01-01

    Eesti Ajaloomuuseumi Maarjamäe lossi renoveeritud tallihoone Tallinnas Pirita tee 66, valminud 2014. Arhitekt Jaak Huimerind (Studio Paralleel OÜ), sisearhitekt ja näituse kujundaja Tarmo Piirmets (Pink OÜ). Eesti Kultuurkapitali Arhitektuuri sihtkapitali renoveerimispreemia 2014

  18. A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia

    International Nuclear Information System (INIS)

    Cerveira, Nuno; Marschalek, Rolf; Teixeira, Manuel R; Meyer, Claus; Santos, Joana; Torres, Lurdes; Lisboa, Susana; Pinheiro, Manuela; Bizarro, Susana; Correia, Cecília; Norton, Lucília

    2010-01-01

    Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion genes have been cloned and characterized at the molecular level. In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia. Cytogenetics, fluorescence in situ hybridization (FISH), molecular studies (RT-PCR and LDI-PCR), and bioinformatic sequence analysis were used to characterize the CT45A2 gene as novel MLL fusion partner in pediatric acute leukemia. Fluorescence in situ hybridization of bone marrow G-banded metaphases demonstrated a cryptic insertion of 11q23 in Xq26.3 involving the MLL gene. Breakpoint fusion analysis revealed that a DNA fragment of 653 kb from 11q23, containing MLL exons 1-9 in addition to 16 other 11q23 genes, was inserted into the upstream region of the CT45A2 gene located at Xq26.3. In addition, a deletion at Xq26.3 encompassing the 3' region of the DDX26B gene (exons 9-16) and the entire CT45A1 gene was identified. RNA analysis revealed the presence of a novel MLL-CT45A2 fusion transcript in which the first 9 exons of the MLL gene were fused in-frame to exon 2 of the CT45A2 gene, resulting in a spliced MLL fusion transcript with an intact open reading frame. The resulting chimeric transcript predicts a fusion protein where the N-terminus of MLL is fused to the entire open reading frame of CT45A2. Finally, we demonstrate that all breakpoint regions are rich in long repetitive motifs, namely LINE/L1 and SINE/Alu sequences, but all breakpoints were exclusively identified outside these repetitive DNA sequences. We have identified CT45A2 as a novel spliced MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia, as a result of a cryptic insertion of 11q23 in Xq26.3. Since CT45A2 is the first Cancer/Testis antigen family gene

  19. Crystal Structure of Human Taspase1, a Crucial Protease Regulating the Function of MLL

    Energy Technology Data Exchange (ETDEWEB)

    Khan,J.; Dunn, B.; Tong, L.

    2005-01-01

    Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for maintaining Hox gene expression patterns. Chromosomal translocations of the MLL gene are associated with leukemia in infants. Taspase1, a threonine aspartase, is a member of the type 2 asparaginase family, but is the only protease in this family. We report here the crystal structures of human activated Taspase1 and its proenzyme, as well as the characterization of the effects of mutations in the active site region using a newly developed fluorogenic assay. The structure of Taspase1 has significant differences from other asparaginases, especially near the active site. Mutation of the catalytic nucleophile, Thr234, abolishes autocatalytic processing in cis but does not completely block proteolysis in trans. The structure unexpectedly showed the binding of a chloride ion in the active site, and our kinetic studies confirm that chlorides ions are inhibitors of this enzyme at physiologically relevant concentrations.

  20. Kas Balti teatrifestival jääb kestma? / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2006-01-01

    Balti teatrifestivali "OmaDraama" esimees Jaak Allik teeb kokkuvõtteid festivalist ja nimetab laureaadid. Viis auhinda pälvisid eestlased - Mart Kivastik näidend "Põrgu Wärk", Hendrik Toompere näidendi lavastus, Harriet Toompere naisosatäitmine, Jan Uuspõld Wiiralti kehastamine, Margus Prangel Tuglase osa eest. Merle Karusoo "Misjonärid" sai auhinna järjepidevuse eest sotsiaalselt aktuaalsete probleemide tõstatamisel. Ülejäänud kaks auhinda said läti United Intimacy trupi lavastus "P:S. Pöialpoiss" ning leedu luuletaja ja näitleja Birut︠ Mar Salomeja Nerise kuju eest lavastuses "Poetess"

  1. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

    Science.gov (United States)

    Jakovcevski, Mira; Ruan, Hongyu; Shen, Erica Y; Dincer, Aslihan; Javidfar, Behnam; Ma, Qi; Peter, Cyril J; Cheung, Iris; Mitchell, Amanda C; Jiang, Yan; Lin, Cong L; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Akbarian, Schahram

    2015-04-01

    Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain largely unexplored. We report that neuronal ablation of the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal forebrain and adult prefrontal cortex (PFC) is associated with increased anxiety and robust cognitive deficits without locomotor dysfunction. In contrast, only mild behavioral phenotypes were observed after ablation of the Mll1 ortholog Kmt2b/Mll2 in PFC. Impaired working memory after Kmt2a/Mll1 ablation in PFC neurons was associated with loss of training-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity. Medial prefrontal layer V pyramidal neurons, a major output relay of the cortex, demonstrated severely impaired synaptic facilitation and temporal summation, two forms of short-term plasticity essential for working memory. Chromatin immunoprecipitation followed by deep sequencing in Mll1-deficient cortical neurons revealed downregulated expression and loss of the transcriptional mark, trimethyl-H3K4, at <50 loci, including the homeodomain transcription factor Meis2. Small RNA-mediated Meis2 knockdown in PFC was associated with working memory defects similar to those elicited by Mll1 deletion. Therefore, mature prefrontal neurons critically depend on maintenance of Mll1-regulated H3K4 methylation at a subset of genes with an essential role in cognition and emotion. Copyright © 2015 the authors 0270-6474/15/355097-12$15.00/0.

  2. MLL-AF4 fusion transcripts in Acute Lymphocytic Leukemia patientsin Children hospital of Tabriz

    Directory of Open Access Journals (Sweden)

    Amir Monfaredan

    2014-08-01

    Full Text Available Background: MLL-AF4 positive Leukemias comprise about 50-70% of acute lymphoid leukemias in children and about 5% of adolescents and adults Despite recent advances in the treatment of hematologic malignancies of children with ALL in particular, but it seems that poor results are obtained from treating this type of malignancy. Perhaps it is due to the lack of enough knowledge about the expression pattern of the fusion gene induced by chromosomal translocations. This study aims to consider several aspects of the common chromosomal disorder, t (4 11: due to lack of accurate statistical results for this type of translocation in our country, acceptable results are provided Sprevalence of isoforms of recombinant genes involved in MLL-AF4 are explained. Materials and methods: Of 36 patients with ALL between 4 months -11 years of age, peripheral blood sampling was done and total RNA extracted and cDNA was made. Then cDNA was amplified in two steps with the PCR and Nested PCR reactions. After electrophoresis the products were compared and analyzed in comparison with the internal control. Results: The results showed that MLL-AF4 recombinant gene expression in the age between 4 to 12 months range is maximum in the second stage by Nested PCR. Also the highest frequency of fusion isoforms of the gene involved in the same age range is e11-e4 isoform with the frequency of 0.13. Conclusion: It seems that investigation of translocation and chromosomal abnormalities using molecular techniques is one of the most accurate and suitable methods for identifying chromosomal characteristics in patients with acute leukemia, particularly ALL.

  3. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias.

    NARCIS (Netherlands)

    Bergh, A. von; Emanuel, B.; Zelderen-Bhola, S. van; Smetsers, A.F.C.M.; Soest, R. van; Stul, M.; Vranckx, H.; Schuuring, E.; Hagemeijer, A.; Kluin, P.

    2000-01-01

    Reciprocal translocations involving the MLL gene on chromosome band 11q23 have been observed in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). In AML, identification of MLL breakpoints is an important prognostic factor. Breakpoints are clustered in an 8 kb DNA fragment

  4. ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

    Science.gov (United States)

    2014-01-01

    Background Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphisms (SNPs) of IKZF1, ARID5B, and CEBPE could be related to the onset of EAL cases (diagnosis). Methods The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay. Logistic regression was used to evaluate the association between SNPs of cases and controls, adjusted on skin color and/or age. The risk was determined by calculating odds ratios (ORs) with 95% confidence interval (CI). Results Children with the IKZF1 SNP had an increased risk of developing MLL-germline ALL in white children. The heterozygous/mutant genotype in ARID5B rs10994982 significantly increased the risk for MLL-germline leukemia in white and non-white children (OR 2.60, 95% CI: 1.09-6.18 and OR 3.55, 95% CI: 1.57-8.68, respectively). The heterozygous genotype in ARID5B rs10821936 increased the risk for MLL-r leukemia in both white and non-white (OR 2.06, 95% CI: 1.12-3.79 and OR 2.36, 95% CI: 1.09-5.10, respectively). Furthermore, ARID5B rs10821936 conferred increased risk for MLL-MLLT3 positive cases (OR 7.10, 95% CI:1.54-32.68). Our data do not show evidence that CEBPE rs2239633 confers increased genetic susceptibility to EAL. Conclusions IKZF1 and CEBPE variants seem to play a minor role in genetic susceptibility to EAL, while ARID5B rs10821936 increased the risk of MLL-MLLT3. This result shows that genetic susceptibility could be associated with the differences regarding MLL breakpoints and partner genes. PMID:24564228

  5. Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

    Directory of Open Access Journals (Sweden)

    Alvaro Muñoz-López

    2016-10-01

    Full Text Available Induced pluripotent stem cells (iPSCs are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming leukemias is an extremely inefficient process. Few studies generated iPSCs from primary chronic myeloid leukemias, but iPSC generation from acute myeloid or lymphoid leukemias (ALL has not been achieved. We attempted to generate iPSCs from different subtypes of B-ALL to address the developmental impact of leukemic fusion genes. OKSM(L-expressing mono/polycistronic-, retroviral/lentiviral/episomal-, and Sendai virus vector-based reprogramming strategies failed to render iPSCs in vitro and in vivo. Addition of transcriptomic-epigenetic reprogramming “boosters” also failed to generate iPSCs from B cell blasts and B-ALL lines, and when iPSCs emerged they lacked leukemic fusion genes, demonstrating non-leukemic myeloid origin. Conversely, MLL-AF4-overexpressing hematopoietic stem cells/B progenitors were successfully reprogrammed, indicating that B cell origin and leukemic fusion gene were not reprogramming barriers. Global transcriptome/DNA methylome profiling suggested a developmental/differentiation refractoriness of MLL-rearranged B-ALL to reprogramming into pluripotency.

  6. ÜEKN-i esimees Juhansoo : "Ostke ESTO 2009 pass, kas olete sellele sõitmas või mitte!" / Jaak Juhansoo ; interv. Jüri Estam

    Index Scriptorium Estoniae

    Juhansoo, Jaak, 1942-2017

    2009-01-01

    Tallinnas 3. ja 4. aprillil 2009 toimunud Ülemaailmse Eesti Kesknõukogu sümpoosionist ja täiskogust räägib ÜEKN juhatuse esimehe kohale tagasivalitud Jaak Juhansoo, kes muuhulgas tunnustab president Toomas Hendrik Ilvese kõnet sümpoosionil. Ilmunud ka: Vaba Eesti Sõna 16. apr. 2009, lk. 3,10; Meie Kodu 22. apr. 2009, lk. 4; Eesti Päevaleht (Stockholm) 22. apr. 2009, lk. 4, pealk.: Ülemaailmne Eesti Kesknõukogu debüteeris istungiga Eestis; Eesti Rada, 2009, nr. 3, lk. 1,3, pealk.: Intervjuu ÜEKNi esimehe Jaak Juhansooga

  7. Theory of drives and emotions - from Sigmund Freud to Jaak Panksepp.

    Science.gov (United States)

    Żechowski, Cezary

    2017-12-30

    The article discusses the development of psychoanalytic theory in the direction of broadening the reflection on their own based on data derived from empirical studies other than clinical case study. Particularly noteworthy is the convergence that followed between neuroscience and psychoanalysis and the rise of the so-called neuropsychoanalysis. Consequently, this led to eject empirical hypotheses and begin research on defense mechanisms, self, memory, dreams, empathy, dynamic unconscious and emotional-motivational processes (theory of drives). Currently neuropsychoanalysis constituted itself as a discipline contained in itself three separate areas: the psychodynamic neuroscience, clinical neuropsychoanalysis and theory building. The article introduces the theory of Jaak Panksepp emotional systems as an example of anintegrated neurobiology of affect, behavioral biology, evolutionary psychology and psychoanalysis. The theory of emotional systems includes the description of the SEEKING system representing basic motivational system of the organism. Apart from a new perspective on the theory of drives described by Sigmund Freud, it offers the possibility to take into account the emotional and motivational systems within the understanding of mental disorders such as depression, addiction and psychosis, which is the core of psychoanalytic thinking.

  8. Kuidas ühiskondlikus leppes lubatud hea tuntavaks tehakse? / Jaak Aaviksoo, Jüri Tamm, Kaul Nurm...[jt.

    Index Scriptorium Estoniae

    2003-01-01

    Küsimusele "missugune oleks nende panus ja plaan esimese aasta jooksul ühiskondlikus leppes fikseeritud eesmärkide saavutamiseks" vastavad Tartu Ülikooli rektor Jaak Aaviksoo, EOK asepresident Jüri Tamm, Eestimaa Talupidajate Keskliidu peadirektor Kaul Nurm, Eesti Kirikute Nõukogu täitevsekretär Eerik Jõks, Eesti Ühistegelise Liidu juhatuse esimees Urmas Laht, Eesti Väike- ja Keskettevõtjate Assotsiatsiooni juhataja Riina Danilson ning Reformierakonna pressinõunik Peep Lillemägi. Samas ka karikatuur

  9. Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.

    Science.gov (United States)

    Trentin, Luca; Bresolin, Silvia; Giarin, Emanuela; Bardini, Michela; Serafin, Valentina; Accordi, Benedetta; Fais, Franco; Tenca, Claudya; De Lorenzo, Paola; Valsecchi, Maria Grazia; Cazzaniga, Giovanni; Kronnie, Geertruy Te; Basso, Giuseppe

    2016-10-04

    To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS and NRAS with incidences ranging from 25 to 50%. Whereas previous studies employed Sanger sequencing, here we used next generation amplicon deep sequencing for in depth evaluation of RAS mutations in 36 paediatric patients at diagnosis of MLL-AF4+ leukaemia. RAS mutations including those in small sub-clones were detected in 63.9% of patients. Furthermore, the mutational analysis of 17 paired samples at diagnosis and relapse revealed complex RAS clone dynamics and showed that the mutated clones present at relapse were almost all originated from clones that were already detectable at diagnosis and survived to the initial therapy. Finally, we showed that mutated patients were indeed characterized by a RAS related signature at both transcriptional and protein levels and that the targeting of the RAS pathway could be of beneficial for treatment of MLL-AF4+ BCP-ALL clones carrying somatic RAS mutations.

  10. LEDGF/p75 as a target for treatment of MLL-dependent leukemia and HIV infection

    Czech Academy of Sciences Publication Activity Database

    Čermáková, K.; Těšina, Petr; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Christ, F.; Debyser, Z.; Řezáčová, Pavlína; Veverka, Václav; De Rijck, J.

    2015-01-01

    Roč. 22, č. 1 (2015), s. 30 ISSN 1211-5894. [Discussions in Structural Molecular Biology. Annual Meeting of the Czech Society for Structural Biology /13./. 19.03.2015-21.03.2015, Nové Hrady] Institutional support: RVO:61388963 Keywords : LEDGF/p75 * leukemia * MLL Subject RIV: CE - Biochemistry

  11. Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus.

    Science.gov (United States)

    Gyárfás, Tobias; Wintgens, Juergen; Biskup, Wolfgang; Oschlies, Ilske; Klapper, Wolfram; Siebert, Reiner; Bens, Susanne; Haferlach, Claudia; Meisel, Roland; Kuhlen, Michaela; Borkhardt, Arndt

    2016-12-01

    Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are common in neonatal AML. A female neonate born at 34 weeks gestation presented with cardiorespiratory failure, hepatosplenomegaly, pancytopenia, and coagulopathy. She required intensive care treatment including mechanical ventilation, high-dose catecholamine therapy, and multiple transfusions. Small intestinal biopsy obtained during laparotomy for meconium ileus revealed an infiltrate by an undifferentiated monoblastic, MLL-rearranged leukemia. No other manifestations of leukemia could be detected. After spontaneous clinical remission, lasting 5 months without any specific treatment, the patient presented with leukemia cutis and full-blown monoblastic leukemia. MLL-AF10-rearranged AML could be re-diagnosed and successfully treated with chemotherapy and hematopoietic stem cell transplantation. Our patient exhibited a unique manifestation of neonatal MLL-AF10 rearranged AML with cardiorespiratory failure and intestinal infiltration. It highlights the importance of leukemia in the differential diagnosis of neonatal distress, congenital hematological abnormalities, and skin lesions.

  12. ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

    Science.gov (United States)

    Garrison, Brian S; Rybak, Adrian P; Beerman, Isabel; Heesters, Balthasar; Mercier, Francois E; Scadden, David T; Bryder, David; Baron, Roland; Rossi, Derrick J

    2017-08-03

    The concept that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as a means of enforcing their unlimited proliferative potential is widely accepted, yet identification of specific factors that regulate self-renewal of normal and cancer stem cells remains limited. Using a comparative transcriptomic approach, we identify ZNF521 / Zfp521 as a conserved hematopoietic stem cell (HSC)-enriched transcription factor in human and murine hematopoiesis whose function in HSC biology remains elusive. Competitive serial transplantation assays using Zfp521 -deficient mice revealed that ZFP521 regulates HSC self-renewal and differentiation. In contrast, ectopic expression of ZFP521 in HSCs led to a robust maintenance of progenitor activity in vitro. Transcriptional analysis of human acute myeloid leukemia (AML) patient samples revealed that ZNF521 is highly and specifically upregulated in AMLs with MLL translocations. Using an MLL-AF9 murine leukemia model and serial transplantation studies, we show that ZFP521 is not required for leukemogenesis, although its absence leads to a significant delay in leukemia onset. Furthermore, knockdown of ZNF521 reduced proliferation in human leukemia cell lines possessing MLL-AF9 translocations. Taken together, these results identify ZNF521/ZFP521 as a critical regulator of HSC function, which facilitates MLL-AF9-mediated leukemic disease in mice.

  13. Järve Keskus : Tallinn, Pärnu mnt. 236 = Järve Centre : 236 Pärnu Rd., Tallinn / Jaak Huimerind

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2003-01-01

    Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Kaastöötajad Kristi Põldme, Indrek Laos, Reet Viigipuu. Avalike ruumide sisekujundus: Mari Kurismaa. Konstruktiivne osa: E-Inseneribüroo. Projekt 2000-2002, valmis 2002. Asendi-, I ja II korruse plaan, 6 vaadet

  14. Hamilton on surnud, tema mõju mitte : in memoriam Richard Hamilton (24. II 1922 - 13. IX 2011) / Kadri Karro ; kommenteerinud Eha Komissarov, Sirje Helme, Jaak Kangilaski

    Index Scriptorium Estoniae

    Karro,Kadri

    2011-01-01

    Briti kunstniku Richard Hamiltoni (1922 - 2011) loomingust eesti kunstiteadlaste Eha Komissarovi, Sirje Helme ja Jaak Kangilaski pilgu läbi. Lähemalt 1956. aastal valminud kollaažist "Mis teeb tänapäeva kodud nii eriliseks, nii meeldivaks?"

  15. Lõuna 2a villa restaureerimine Pärnus = Restoration of Lõuna 2a villa in Pärnu / Jaak Huimerind, Mari Kurismaa, Mart Kalm ; kommenteerinud Liina Jänes

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2015-01-01

    Villa Pärnus Lõuna tänav 2a, valminud 1936, restaureeritud 2014. Hoone arhitektid Olev Siinmaa, Anton Soans, restaureerimisarhitekt Jaak Huimerind, sisearhitekt Mari Kurismaa. Eesti Kultuurkapitali Arhitektuuri sihtkapitali restaureerimispreemia 2014

  16. Mida arvate ideest, et kõrgkoole võiks juhtida ülikoolivälistest inimestest koosnev nõukogu? / Jaak Aaviksoo, Maris Mälzer, Peeter Kreitzberg, Peep Sürje

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad Tartu Ülikooli eelmine rektor Jaak Aaviksoo, Eesti Üliõpilaskondade Liidu esimees Maris Mälzer, Riigikogu kultuurikomisjoni esimees Peeter Kreitzberg ja Tallinna Tehnikaülikooli rektor Peep Sürje

  17. Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia.

    Science.gov (United States)

    Yin, Min; Chen, Zhiying; Ouyang, Yetong; Zhang, Huiyan; Wan, Zhigang; Wang, Han; Wu, Wei; Yin, Xiaoping

    2017-06-29

    Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial activation using an in vitro thrombin toxicity model applied to primary human microglia. A miRNA array identified 22 differential miRNA candidates. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) identified miR-181c as the most significantly downregulated miRNA. TargetScan analysis identified mixed lineage leukemia-1 (MLL1) as a putative gene target for miR-181c. qRT-PCR was applied to assess tumor necrosis factor-alpha (TNF-α), miR-181c, and MLL1 levels following thrombin or proteinase-activated receptor-4-specific activating peptide (PAR4AP) exposure. Anti-TNF-α antibodies and tumor necrosis factor receptor (TNFR) silencing were employed to test TNF-α/TNFR dependence. A dual-luciferase reporter system and miR-181c mimic transfection assessed whether mir-181c directly binds to and negatively regulates MLL1. Nuclear factor kappa-B (NF-κB)-dependent luciferase reporter assays and NF-κB target gene expression were assessed in wild-type (MLL1+) and MLL1-silenced cells. Thrombin or PAR4AP-induced miR-181c downregulation (p < 0.05) and MLL1 upregulation (p < 0.05) that were dependent upon TNF-α/TNFR. miR-181c decreased wild-type MLL1 3'-UTR luciferase reporter activity (p < 0.05), and a miR-181c mimic suppressed MLL1 expression (p < 0.05). Thrombin treatment increased, while miR-181c reduced, NF-κB activity and NF-κB target gene expression in both wild-type (MLL1+) and MLL1-silenced cells (p < 0.05). Thrombin-induced, TNF-α/TNFR-dependent miR-181c downregulation promotes MLL1 expression, increases NF-κB activity, and upregulates NF-κB target gene expression. As miR-181c opposes thrombin's stimulation of pro-inflammatory NF-κB activity, miR-181c mimic therapy may show promise in controlling thrombin

  18. MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

    Science.gov (United States)

    Sebastian, Soji; Sreenivas, Prethish; Sambasivan, Ramkumar; Cheedipudi, Sirisha; Kandalla, Prashanth; Pavlath, Grace K.; Dhawan, Jyotsna

    2009-01-01

    Most cells in adult tissues are nondividing. In skeletal muscle, differentiated myofibers have exited the cell cycle permanently, whereas satellite stem cells withdraw transiently, returning to active proliferation to repair damaged myofibers. We have examined the epigenetic mechanisms operating in conditional quiescence by analyzing the function of a predicted chromatin regulator mixed lineage leukemia 5 (MLL5) in a culture model of reversible arrest. MLL5 is induced in quiescent myoblasts and regulates both the cell cycle and differentiation via a hierarchy of chromatin and transcriptional regulators. Knocking down MLL5 delays entry of quiescent myoblasts into S phase, but hastens S-phase completion. Cyclin A2 (CycA) mRNA is no longer restricted to S phase, but is induced throughout G0/G1, with activation of the cell cycle regulated element (CCRE) in the CycA promoter. Overexpressed MLL5 physically associates with the CCRE and impairs its activity. MLL5 also regulates CycA indirectly: Cux, an activator of CycA promoter and S phase is induced in RNAi cells, and Brm/Brg1, CCRE-binding repressors that promote differentiation are repressed. In knockdown cells, H3K4 methylation at the CCRE is reduced, reflecting quantitative global changes in methylation. MLL5 appears to lack intrinsic histone methyl transferase activity, but regulates expression of histone-modifying enzymes LSD1 and SET7/9, suggesting an indirect mechanism. Finally, expression of muscle regulators Pax7, Myf5, and myogenin is impaired in MLL5 knockdown cells, which are profoundly differentiation defective. Collectively, our results suggest that MLL5 plays an integral role in novel chromatin regulatory mechanisms that suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. PMID:19264965

  19. Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

    Science.gov (United States)

    Huang, Xu; Spencer, Gary J; Lynch, James T; Ciceri, Filippo; Somerville, Tim D D; Somervaille, Tim C P

    2013-01-01

    Through a targeted knockdown (KD) screen of chromatin regulatory genes we identified the EP400 complex components EPC1 and EPC2 as critical oncogenic co-factors in acute myeloid leukemia (AML). EPC1 and EPC2 were required for the clonogenic potential of human AML cells of multiple molecular subtypes. Focusing on MLL-mutated AML as an exemplar, Epc1 or Epc2 KD induced apoptosis of murine MLL-AF9 AML cells and abolished leukemia stem cell potential. By contrast, normal hematopoietic stem and progenitor cells (HSPC) were spared. Similar selectivity was observed for human primary AML cells versus normal CD34+ HSPC. In keeping with these distinct functional consequences, Epc1 or Epc2 KD induced divergent transcriptional consequences in murine MLL-AF9 granulocyte-macrophage progenitor-like (GMP) cells versus normal GMP, with a signature of increased MYC activity in leukemic but not normal cells. This was caused by accumulation of MYC protein and was also observed following KD of other EP400 complex genes. Pharmacological inhibition of MYC:MAX dimerization, or concomitant MYC KD, reduced apoptosis following EPC1 KD, linking the accumulation of MYC to cell death. Therefore EPC1 and EPC2 are components of a complex which directly or indirectly serves to prevent MYC accumulation and AML cell apoptosis, thus sustaining oncogenic potential. PMID:24166297

  20. Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

    Directory of Open Access Journals (Sweden)

    Elif Nihal Korkmaz

    Full Text Available The KIX domain of CBP is a transcriptional coactivator. Concomitant binding to the activation domain of proto-oncogene protein c-Myb and the transactivation domain of the trithorax group protein mixed lineage leukemia (MLL transcription factor lead to the biologically active ternary MLL∶KIX∶c-Myb complex which plays a role in Pol II-mediated transcription. The binding of the activation domain of MLL to KIX enhances c-Myb binding. Here we carried out molecular dynamics (MD simulations for the MLL∶KIX∶c-Myb ternary complex, its binary components and KIX with the goal of providing a mechanistic explanation for the experimental observations. The dynamic behavior revealed that the MLL binding site is allosterically coupled to the c-Myb binding site. MLL binding redistributes the conformational ensemble of KIX, leading to higher populations of states which favor c-Myb binding. The key element in the allosteric communication pathways is the KIX loop, which acts as a control mechanism to enhance subsequent binding events. We tested this conclusion by in silico mutations of loop residues in the KIX∶MLL complex and by comparing wild type and mutant dynamics through MD simulations. The loop assumed MLL binding conformation similar to that observed in the KIX∶c-Myb state which disfavors the allosteric network. The coupling with c-Myb binding site faded, abolishing the positive cooperativity observed in the presence of MLL. Our major conclusion is that by eliciting a loop-mediated allosteric switch between the different states following the binding events, transcriptional activation can be regulated. The KIX system presents an example how nature makes use of conformational control in higher level regulation of transcriptional activity and thus cellular events.

  1. Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia.

    Science.gov (United States)

    Wang, Rong; Feng, Wenli; Yang, Feifei; Yang, Xiao; Wang, Lina; Chen, Chong; Hu, Yuting; Ren, Qian; Zheng, Guoguang

    2018-02-01

    Macrophage colony-stimulating factor (M-CSF) regulates both malignant cells and microenvironmental cells. Its splicing isoforms show functional heterogeneity. However, their roles on leukemia have not been well established. Here, the expression of total M-CSF in patients with hematopoietic malignancies was analyzed. The roles of M-CSF isoforms on the progression of acute myeloid leukemia (AML) were studied by establishing MLL-AF9-induced mouse AML models with high level membrane-bound M-CSF (mM-CSF) or soluble M-CSF (sM-CSF). Total M-CSF was highly expressed in myeloid leukemia patients. Furthermore, mM-CSF but not sM-CSF prolonged the survival of leukemia mice. While sM-CSF was more potent to promote proliferation and self-renew, mM-CSF was more potent to promote differentiation. Moreover, isoforms had different effects on leukemia-associated macrophages (LAMs) though they both increase monocytes/macrophages by growth-promoting and recruitment effects. In addition, mM-CSF promoted specific phagocytosis of leukemia cells by LAMs. RNA-seq analysis revealed that mM-CSF enhanced phagocytosis-associated genes and activated oxidative phosphorylation and metabolism pathway. These results highlight heterogeneous effects of M-CSF isoforms on AML progression and the mechanisms of mM-CSF, that is, intrinsically promoting AML cell differentiation and extrinsically enhancing infiltration of macrophages and phagocytosis by macrophages, which may provide potential clues for clinical diagnosis and therapy. © 2017 Australasian Society for Immunology Inc.

  2. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

    Science.gov (United States)

    Klaus, Christine R; Iwanowicz, Dorothy; Johnston, Danielle; Campbell, Carly A; Smith, Jesse J; Moyer, Mikel P; Copeland, Robert A; Olhava, Edward J; Scott, Margaret Porter; Pollock, Roy M; Daigle, Scott R; Raimondi, Alejandra

    2014-09-01

    EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol], a small-molecule inhibitor of the protein methyltransferase DOT1L, is currently under clinical investigation for acute leukemias bearing MLL-rearrangements (MLL-r). In this study, we evaluated EPZ-5676 in combination with standard of care (SOC) agents for acute leukemias as well as other chromatin-modifying drugs in cellular assays with three human acute leukemia cell lines: MOLM-13 (MLL-AF9), MV4-11 (MLL-AF4), and SKM-1 (non-MLL-r). Studies were performed to evaluate the antiproliferative effects of EPZ-5676 combinations in a cotreatment model in which the second agent was added simultaneously with EPZ-5676 at the beginning of the assay, or in a pretreatment model in which cells were incubated for several days in the presence of EPZ-5676 prior to the addition of the second agent. EPZ-5676 was found to act synergistically with the acute myeloid leukemia (AML) SOC agents cytarabine or daunorubicin in MOLM-13 and MV4-11 MLL-r cell lines. EPZ-5676 is selective for MLL-r cell lines as demonstrated by its lack of effect either alone or in combination in the nonrearranged SKM-1 cell line. In MLL-r cells, the combination benefit was observed even when EPZ-5676 was washed out prior to the addition of the chemotherapeutic agents, suggesting that EPZ-5676 sets up a durable, altered chromatin state that enhances the chemotherapeutic effects. Our evaluation of EPZ-5676 in conjunction with other chromatin-modifying drugs also revealed a consistent combination benefit, including synergy with DNA hypomethylating agents. These results indicate that EPZ-5676 is highly efficacious as a single agent and synergistically acts with other chemotherapeutics, including AML SOC drugs and DNA hypomethylating agents in MLL-r cells. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.

  3. A novel RT-qPCR assay for quantification of the MLL-MLLT3 fusion transcript in acute myeloid leukaemia

    DEFF Research Database (Denmark)

    Abildgaard, Lotte; Ommen, Hans Beier; Lausen, Birgitte Frederiksen

    2013-01-01

    OBJECTIVES: Patients with acute myeloid leukaemia (AML) of the monocytic lineage often lack molecular markers for minimal residual disease (MRD) monitoring. The MLL-MLLT3 fusion transcript found in patients with AML harbouring t(9;11) is amenable to RT-qPCR quantification but because...... of the heterogeneity of translocation break points, the MLL-MLLT3 fusion gene is a challenging target. We hypothesised that MRD monitoring using MLL-MLLT3 as a RT-qPCR marker is feasible in the majority of patients with t(9;11)-positive AML. METHODS: Using a locked nucleic acid probe, we developed a sensitive RT......-qPCR assay for quantification of the most common break point region of the MLL-MLLT3 fusion gene. Five paediatric patients with t(9;11)-positive AML were monitored using the MLL-MLLT3 assay. RESULTS: A total of 43 bone marrow (BM) and 52 Peripheral blood (PB) samples were collected from diagnosis until...

  4. Favorable outcome in non-infant children with MLL-AF4-positive acute lymphoblastic leukemia: a report from the Tokyo Children's Cancer Study Group.

    Science.gov (United States)

    Tomizawa, Daisuke; Kato, Motohiro; Takahashi, Hiroyuki; Fujimura, Junya; Inukai, Takeshi; Fukushima, Takashi; Kiyokawa, Nobutaka; Koh, Katsuyoshi; Manabe, Atsushi; Ohara, Akira

    2015-11-01

    Unlike acute lymphoblastic leukemia (ALL) in infants, MLL gene rearrangement (MLL-r) is rare in ALL children (≥1 year old). The outcome and optimal treatment options for MLL-r ALL remain controversial. Among the 1827 children enrolled in the Tokyo Children's Cancer Study Group ALL studies L95-14, L99-15, L99-1502, L04-16, and L07-1602 (1995-2009), 25 MLL-r ALL patients (1.3 %) were identified. Their median age and leukocyte count at diagnosis was 2 years old (range 1-15 years) and 27,690/μL (range 1800-1,113,000/μL), respectively. All but one patient achieved complete remission (CR) after induction therapy, and 19 underwent allogeneic hematopoietic stem cell transplantation (HSCT) in first CR according to the protocol. The 5-year event-free survival (EFS) and overall survival (OS) rate were 60.0 % [standard error (SE), 9.7 %] and 64.0 % (SE 9.6 %), respectively. Notably, 9/12 cases with MLL-AF4-positive ALL are alive in continuous CR with a 75.0 % (SE 12.5 %) EFS rate. The causes of treatment failure were as follows: one induction failure, five relapses, and five transplant-related deaths. With intensive chemotherapy and allogeneic HSCT, favorable outcome of children (≥1 year old) with MLL-AF4-positive ALL was observed. However, considering the risk of acute and late toxicities associated with HSCT, its indication should be restricted.

  5. Morus alba Leaf Lectin (MLL) Sensitizes MCF-7 Cells to Anoikis by Inhibiting Fibronectin Mediated Integrin-FAK Signaling through Ras and Activation of P38 MAPK

    Science.gov (United States)

    Saranya, Jayaram; Shilpa, Ganesan; Raghu, Kozhiparambil G.; Priya, Sulochana

    2017-01-01

    Lectins are a unique class of carbohydrate binding proteins/glycoproteins, and many of them possess anticancer properties. They can induce cell cycle arrest and apoptosis, inhibit protein synthesis, telomerase activity and angiogenesis in cancer cells. In the present study, we have demonstrated the effect of Morus alba leaf lectin (MLL) on anoikis induction in MCF-7 cells. Anoikis induction in cancer cells has a significant role in preventing early stage metastasis. MLL treatment in monolayers of MCF-7 cells caused significant detachment of cells in a time and concentration dependent manner. The detached cells failed to re-adhere and grew even to culture plates coated with different matrix proteins. DNA fragmentation, membrane integrity studies, annexin V staining, caspase 9 activation and upregulation of Bax/Bad confirmed that the detached cells underwent apoptosis. Upregulation of matrix metalloproteinase 9 (MMP-9) caused a decrease in fibronectin (FN) production which facilitated the cells to detach by blocking the FN mediated downstream signaling. On treatment with MLL, we have observed downregulation of integrin expression, decreased phosphorylation of focal adhesion kinase (FAK), loss in FAK-integrin interaction and active Ras. MLL treatment downregulated the levels of phosphorylated Akt and PI3K. Also, we have studied the effect of MLL on two stress activated protein kinases p38 MAPK and JNK. p38 MAPK activation was found to be elevated, but there was no change in the level of JNK. Thus our study substantiated the possible antimetastatic effect of MLL by inducing anoikis in MCF-7 cells by activation of caspase 9 and proapoptotic Bax/Bad by blockage of FN mediated integrin/FAK signaling and partly by activation of p38 MAPK. PMID:28223935

  6. GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.

    Science.gov (United States)

    Dietrich, Philipp A; Yang, Chen; Leung, Halina H L; Lynch, Jennifer R; Gonzales, Estrella; Liu, Bing; Haber, Michelle; Norris, Murray D; Wang, Jianlong; Wang, Jenny Yingzi

    2014-11-20

    β-catenin is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML). Targeted inhibition of β-catenin signaling has been hampered by the lack of pathway components amenable to pharmacologic manipulation. Here we identified a novel β-catenin regulator, GPR84, a member of the G protein-coupled receptor family that represents a highly tractable class of drug targets. High GPR84 expression levels were confirmed in human and mouse AML LSCs compared with hematopoietic stem cells (HSCs). Suppression of GPR84 significantly inhibited cell growth by inducing G1-phase cell-cycle arrest in pre-LSCs, reduced LSC frequency, and impaired reconstitution of stem cell-derived mixed-lineage leukemia (MLL) AML, which represents an aggressive and drug-resistant subtype of AML. The GPR84-deficient phenotype in established AML could be rescued by expression of constitutively active β-catenin. Furthermore, GPR84 conferred a growth advantage to Hoxa9/Meis1a-transduced stem cells. Microarray analysis demonstrated that GPR84 significantly upregulated a small set of MLL-fusion targets and β-catenin coeffectors, and downregulated a hematopoietic cell-cycle inhibitor. Altogether, our data reveal a previously unrecognized role of GPR84 in maintaining fully developed AML by sustaining aberrant β-catenin signaling in LSCs, and suggest that targeting the oncogenic GPR84/β-catenin signaling axis may represent a novel therapeutic strategy for AML. © 2014 by The American Society of Hematology.

  7. Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.

    Science.gov (United States)

    Dai, Qian; Shen, Yang; Wang, Yan; Wang, Xin; Francisco, Joel Celio; Luo, Zhuojuan; Lin, Chengqi

    2017-12-01

    Transposable elements (TEs) compose about 40% of the murine genome. Retrotransposition of active TEs such as LINE-1 (L1) tremendously impacts genetic diversification and genome stability. Therefore, transcription and transposition activities of retrotransposons are tightly controlled. Here, we show that the Krüppel-like zinc finger protein Zfp281 directly binds and suppresses a subset of retrotransposons, including the active young L1 repeat elements, in mouse embryonic stem (ES) cells. In addition, we find that Zfp281-regulated L1s are highly enriched for 5-hydroxymethylcytosine (5hmC) and H3K4me3. The COMPASS-like H3K4 methyltransferase Mll2 is the major H3K4me3 methylase at the Zfp281-regulated L1s and required for their proper expression. Our studies also reveal that Zfp281 functions partially through recruiting the L1 regulators DNA hydroxymethylase Tet1 and Sin3A, and restricting Mll2 at these active L1s, leading to their balanced expression. In summary, our data indicate an instrumental role of Zfp281 in suppressing the young active L1s in mouse ES cells. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  8. Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

    Science.gov (United States)

    Cruickshank, M N; Ford, J; Cheung, L C; Heng, J; Singh, S; Wells, J; Failes, T W; Arndt, G M; Smithers, N; Prinjha, R K; Anderson, D; Carter, K W; Gout, A M; Lassmann, T; O'Reilly, J; Cole, C H; Kotecha, R S; Kees, U R

    2017-01-01

    To address the poor prognosis of mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia (iALL), we generated a panel of cell lines from primary patient samples and investigated cytotoxic responses to contemporary and novel Food and Drug Administration-approved chemotherapeutics. To characterize representation of primary disease within cell lines, molecular features were compared using RNA-sequencing and cytogenetics. High-throughput screening revealed variable efficacy of currently used drugs, however identified consistent efficacy of three novel drug classes: proteasome inhibitors, histone deacetylase inhibitors and cyclin-dependent kinase inhibitors. Gene expression of drug targets was highly reproducible comparing iALL cell lines to matched primary specimens. Histone deacetylase inhibitors, including romidepsin (ROM), enhanced the activity of a key component of iALL therapy, cytarabine (ARAC) in vitro and combined administration of ROM and ARAC to xenografted mice further reduced leukemia burden. Molecular studies showed that ROM reduces expression of cytidine deaminase, an enzyme involved in ARAC deactivation, and enhances the DNA damage–response to ARAC. In conclusion, we present a valuable resource for drug discovery, including the first systematic analysis of transcriptome reproducibility in vitro, and have identified ROM as a promising therapeutic for MLL-rearranged iALL. PMID:27443263

  9. Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expression.

    Science.gov (United States)

    Pascual-Garcia, Pau; Jeong, Jieun; Capelson, Maya

    2014-10-23

    The nuclear pore complex is a transport channel embedded in the nuclear envelope and made up of 30 different components termed nucleoporins (Nups). In addition to their classical role in transport, a subset of Nups has a conserved role in the regulation of transcription via direct binding to chromatin. The molecular details of this function remain obscure, and it is unknown how metazoan Nups are recruited to their chromatin locations or what transcription steps they regulate. Here, we demonstrate genome-wide and physical association between Nup98 and histone-modifying complexes MBD-R2/NSL [corrected] and Trx/MLL. Importantly, we identify a requirement for MBD-R2 in recruitment of Nup98 to many of its genomic target sites. Consistent with its interaction with the Trx/MLL complex, Nup98 is shown to be necessary for Hox gene expression in developing fly tissues. These findings introduce roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of Nup98 fusions in leukemia.

  10. Kaberla kalmistu 12.-13. sajandi klaashelmed / Irita Kallis

    Index Scriptorium Estoniae

    Kallis, Irita

    2010-01-01

    Kaberla kalmistult leitud klaashelmestest, põhitähelepanu on 12.-13. saj. matuste inventari hulka kuulunud leiumaterjalil. Ülevaade helmeste esimemisvariatsioonidest helmekeedes, võimalikust tähendusest ja väärtusest ning samatüübiliste helmeste dateeringutest naaberaladel

  11. Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

    International Nuclear Information System (INIS)

    Sakamoto, K; Imamura, T; Yano, M; Yoshida, H; Fujiki, A; Hirashima, Y; Hosoi, H

    2014-01-01

    All-trans retinoic acid (ATRA) is well established as differentiation therapy for acute promyelocytic leukemia (APL) in which the PML–RARα (promyelocytic leukemia-retinoic acid receptor α) fusion protein causes blockade of the retinoic acid (RA) pathway; however, in types of acute myeloid leukemia (AML) other than APL, the mechanism of RA pathway inactivation is not fully understood. This study revealed the potential mechanism of high ATRA sensitivity of mixed-lineage leukemia (MLL)-AF9-positive AML compared with MLL-AF4/5q31-positive AML. Treatment with ATRA induced significant myeloid differentiation accompanied by upregulation of RARα, C/EBPα, C/EBPε and PU.1 in MLL-AF9-positive but not in MLL-AF4/5q31-positive cells. Combining ATRA with cytarabine had a synergistic antileukemic effect in MLL-AF9-positive cells in vitro. The level of dimethyl histone H3 lysine 4 (H3K4me2) in the RARα gene-promoter region, PU.1 upstream regulatory region (URE) and RUNX1+24/+25 intronic enhancer was higher in MLL-AF9-positive cells than in MLL-AF4-positive cells, and inhibiting lysine-specific demethylase 1, which acts as a histone demethylase inhibitor, reactivated ATRA sensitivity in MLL-AF4-positive cells. These findings suggest that the level of H3K4me2 in the RARα gene-promoter region, PU.1 URE and RUNX1 intronic enhancer is determined by the MLL-fusion partner. Our findings provide insight into the mechanisms of ATRA sensitivity in AML and novel treatment strategies for ATRA-resistant AML

  12. Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11(q21;q23/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    F. Marchesi

    2011-01-01

    Full Text Available Translocation t(4;11(q21;q23 leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL in adult patients. Patients expressing this chromosomal aberration present typical biological, immunophenotypic, and clinical features. This form of leukemia is universally recognized as high-risk leukemia and treatment intensification with allogeneic hematopoietic stem cell transplantation (HSCT in first complete remission (CR could be a valid option to improve prognosis, but data obtained from the literature are controversial. In this review, we briefly describe pathogenetic, clinical, and prognostic characteristics of adult t(4;11(q21;q23/MLL-AF4 positive ALL and provide a review of the clinical outcome reported by the most important cooperative groups worldwide.

  13. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

    Science.gov (United States)

    Gardner, Rebecca; Wu, David; Cherian, Sindhu; Fang, Min; Hanafi, Laïla-Aïcha; Finney, Olivia; Smithers, Hannah; Jensen, Michael C; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J

    2016-05-19

    Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. All patients achieved complete remission (CR) in the bone marrow by flow cytometry after CD19 CAR-T-cell therapy; however, within 1 month of CAR-T-cell infusion, 2 of the patients developed acute myeloid leukemia (AML) that was clonally related to their B-ALL, a novel mechanism of CD19-negative immune escape. These reports have implications for the management of patients with relapsed and refractory MLL-B-ALL who receive CD19 CAR-T-cell therapy. © 2016 by The American Society of Hematology.

  14. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

    Energy Technology Data Exchange (ETDEWEB)

    Karatas, Hacer; Li, Yangbing; Liu, Liu; Ji, Jiao; Lee, Shirley; Chen, Yong; Yang, Jiuling; Huang, Liyue; Bernard, Denzil; Xu, Jing; Townsend, Elizabeth C.; Cao, Fang; Ran, Xu; Li, Xiaoqin; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A; Lei, Ming; Dou, Yali; Wang, Shaomeng (Michigan)

    2017-06-06

    We report herein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domain 5 (WDR5) and block the WDR5–mixed lineage leukemia (MLL) protein–protein interaction. Compound 18 (MM-589) binds to WDR5 with an IC50 value of 0.90 nM (Ki value <1 nM) and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 value of 12.7 nM. Compound 18 potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations and is >40 times better than the previously reported compound MM-401. Cocrystal structures of 16 and 18 complexed with WDR5 provide structural basis for their high affinity binding to WDR5. Additionally, we have developed and optimized a new AlphaLISA-based MLL HMT functional assay to facilitate the functional evaluation of these designed compounds. Compound 18 represents the most potent inhibitor of the WDR5–MLL interaction reported to date, and further optimization of 18 may yield a new therapy for acute leukemia.

  15. Kunstielu / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2016-01-01

    Kunstipoliitiline retoorika. Kunsti esteetilised paradigmad. Võimude pragmaatika. Majanduslik soosing ja poliitilised keelud. Kunstnike Liit. Näitused. Noortekoondis. Surve tugevnemine viis perestroikani. Kunstielu uuel ärkamisajal.

  16. Soovimatud lapsed / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Christian Mungiu "Neli kuud, kolm nädalat ja kaks päeva" (Rumeenia) ; Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Andrei Zvjagintsevi "Pagendus" (Izgnanije" ; muusika Arvo Pärdilt ; Venemaa) ; Kadri Kõusaare "Magnus"

  17. Wow! Tallinn! / Jaak Rand

    Index Scriptorium Estoniae

    Rand, Jaak

    2006-01-01

    Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions. Lisatud Jüri Sillarti filmograafia lk. 83

  18. Kunstioksjonitest / Jaak Olep

    Index Scriptorium Estoniae

    Olep, Jaak, 1945-2000

    1998-01-01

    Sotheby ja Christie oksjonifirmadest. Kunstioksjonite korraldamisest Sotheby näitel. Venelaste ilmumisest oksjonitele 90ndate aastate alguses, Venemaa oma oksjonifirmadest. Hindadest maailmas. Šveitsi oksjonifirma Antiquorum oksjonist "Erootika ja seks kunstis".

  19. Pahupidi presidendikampaania / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2006-01-01

    Autor leiab, et Tarvastu vallavolikogu koalitsiooni otsus presidendivalimistel Arnold Rüütlit mitte toetada on teatud erakondade negatiivne valimiskampaania. Ilmunud ka Põhjarannik, 2006/Apr/20, lk. 2 ; Meie Maa, 2006/Apr/20, lk. 2 ; Vooremaa, 2006/Apr/20, lk. 2 ; Sakala, 2006/Apr/18, lk. 2 ; Severnoje Poberezhje, 2006/Apr/20, lk. 2

  20. Mehatroonik / Piret Jaaks

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2005-01-01

    AS-i Overall Eesti juhi ja asutaja Andres Haameri elukäigust ning firma loomisest. Töökogemus, õppimine, usk iseendasse ja teistesse on need, mis aitasid realiseerida oma firma loomise ning tuua ettevõte tühjale turule. Lisa: Kuidas firma arenes

  1. Acute myocardial infarction during induction chemotherapy for acute MLL t(4;11 leukemia with lineage switch and extreme leukocytosis

    Directory of Open Access Journals (Sweden)

    Čolović Nataša

    2015-01-01

    Full Text Available Introduction. In patients with acute leukemias hemorrhage is the most frequent problem. Vein thrombotic events may appear rarely but arterial thromboses are exceptionally rare. We present a patient with acute leukemia and bilateral deep leg vein thrombosis who developed an acute myocardial infarction (AMI during induction chemotherapy. The etiology and treatment of AMI in patients with acute leukemia, which is a rare occurrence, is discussed. Case Outline. In April of 2012 a 37-year-old male presented with bilateral deep leg vein thrombosis and malaise. Laboratory data were as follows: Hb 118 g/L, WBC 354x109/L (with 91% blasts in differential leukocyte count, platelets 60Ч109/L. Bone marrow aspirate and immunophenotype revealed the presence of acute lymphoblastic leukemia. Cytogenetic analysis was as follows: 46,XY,t(4;11(q21:q23 [2]/62-82,XY,t(4;11[18]. Molecular analysis showed MLL-AF4 rearrangement. The patient was on low molecular weight heparin and combined chemotherapy according to protocol HyperCVAD. On day 10 after chemotherapy he got chest pain. Three days later AMI was diagnosed (creatine kinase 66 U/L, CK-MB 13U/L, troponin 1.19 μg/L. Electrocardiogram showed the ST elevation in leads D1, D2, aVL, V5 and V6 and “micro q” in D1. On echocardiography, hypokinesia of the left ventricle and ejection fraction of 39% was found. After recovering from AMI and restoring left ventricle ejection fraction to 59%, second course of HyperCVAD was given. The control bone marrow aspirate showed 88% of blasts but with monoblastic appearance. Flow cytometry confirmed a lineage switch from lymphoblasts to monoblasts. In further course of the disease he was treated with a variety of chemotherapeutic combinations without achieving remission. Eventually, palliative chemotherapy was administered to reduce the bulk of blasts. He died five months after the initial diagnosis. Conclusion. AMI in young adults with acute leukemia is a very rare complication

  2. Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study

    DEFF Research Database (Denmark)

    Mann, Georg; Attarbaschi, Andishe; Schrappe, Martin

    2010-01-01

    received chemotherapy only (P = .03). However, the advantage was restricted to a subgroup with 2 additional unfavorable prognostic features: age less than 6 months and either poor response to steroids at day 8 or leukocytes more than or equal to 300 g/L. Ninety-seven of 297 MLL(+) patients (33%) had...

  3. Determination of the extraction efficiency for {sup 233}U source α-recoil ions from the MLL buffer-gas stopping cell

    Energy Technology Data Exchange (ETDEWEB)

    Wense, Lars v.d.; Seiferle, Benedict; Thirolf, Peter G. [Ludwig-Maximilians-Universitaet Muenchen, Garching (Germany); Laatiaoui, Mustapha [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Helmholtz Institut Mainz, Mainz (Germany)

    2015-03-01

    Following the α decay of {sup 233}U, {sup 229}Th recoil ions are shown to be extracted in a significant amount from the MLL buffer-gas stopping cell. The produced recoil ions and subsequent daughter nuclei are mass purified with the help of a customized quadrupole mass spectrometer. The combined extraction and mass purification efficiency for {sup 229}Th{sup 3+} is determined via MCP-based measurements and via the direct detection of the {sup 229}Th α decay. A large value of (10±2)% for the combined extraction and mass purification efficiency of {sup 229}Th{sup 3+} is obtained at a mass resolution of about 1u/e. In addition to {sup 229}Th, also other α-recoil ions of the {sup 233,} {sup 232}U decay chains are addressed. (orig.)

  4. Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.

    Science.gov (United States)

    Koues, Olivia I; Mehta, Ninad T; Truax, Agnieszka D; Dudley, R Kyle; Brooks, Jeanne K; Greer, Susanna F

    2010-02-04

    Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription. Our previous studies indicate that H3 lysine 4 trimethylation at cytokine-inducible MHC-II and CIITA promoters is dependent on proteolytic-independent functions of 19S ATPases. In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters. In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1. Taken together, these experiments suggest that the 19S proteasome plays a crucial role in the initial reorganization of events enabling the relaxation of the repressive chromatin structure surrounding inducible promoters.

  5. Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation

    Directory of Open Access Journals (Sweden)

    Koues Olivia I

    2010-02-01

    Full Text Available Abstract Background Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC-II and class II transactivator (CIITA promoters, implicating Sug1 in events required to initiate mammalian transcription. Results Our previous studies indicate that H3 lysine 4 trimethylation at cytokine-inducible MHC-II and CIITA promoters is dependent on proteolytic-independent functions of 19S ATPases. In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL/complex of proteins associated with Set I (COMPASS complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters. In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1. Conclusion Taken together, these experiments suggest that the 19S proteasome plays a crucial role in the initial reorganization of events enabling the relaxation of the repressive chromatin structure surrounding inducible promoters.

  6. The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.

    Science.gov (United States)

    Lu, Chunwan; Paschall, Amy V; Shi, Huidong; Savage, Natasha; Waller, Jennifer L; Sabbatini, Maria E; Oberlies, Nicholas H; Pearce, Cedric; Liu, Kebin

    2017-01-01

    Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1 immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to checkpoint immunotherapy is unknown. The aim of this study is to elucidate the underlying mechanism of PD-L1 expression regulation in the context of pancreatic cancer immune evasion. Pancreatic cancer mouse models and human specimens were used to determine PD-L1 and PD-1 expression and cancer immune evasion. Histone methyltransferase inhibitors, RNAi, and overexpression were used to elucidate the underlying molecular mechanism of PD-L1 expression regulation. All statistical tests were two-sided. PD-L1 is expressed in 60% to 90% of tumor cells in human pancreatic carcinomas and in nine of 10 human pancreatic cancer cell lines. PD-1 is expressed in 51.2% to 52.1% of pancreatic tumor-infiltrating cytotoxic T lymphocytes (CTLs). Tumors grow statistically significantly faster in FasL-deficient mice than in wild-type mice (P = .03-.001) and when CTLs are neutralized (P = .03-evasion. Targeting the MLL1-H3K4me3 axis is an effective approach to enhance the efficacy of checkpoint immunotherapy against pancreatic cancer. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  7. FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.

    Science.gov (United States)

    Nasilowska-Adamska, Barbara; Solarska, Iwona; Paluszewska, Monika; Malinowska, Iwona; Jedrzejczak, Wieslaw W; Warzocha, Krzysztof

    2014-04-01

    Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and mixed-lineage leukemia gene-partial tandem duplication (MLL-PTD) are aberrations associated with leukemia which indicate unsatisfactory prognosis. Downstream regulatory targets of FLT3-ITD and MLL-PTD are not well defined. We have analyzed the expression of MDR-1, multidrug resistant protein-1 (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) messenger RNA (mRNA) in relation to the mutational status of FLT3-ITD and MLL-PTD in 185 acute myeloid leukemia (AML) adult patients. The real-time quantitative polymerase chain reaction method was performed to assess the expression of the MDR-1, MRP-1, BCRP, and LRP mRNA, and the results were presented as coefficients calculated using an intermediate method according to Pfaffl's rule. Significantly higher expressions of MDR-1 mRNA were found in patients who did not harbor FLT3-ITD (0.20 vs. 0.05; p = 0.0001) and MRP-1 mRNA in patients with this mutation (0.96 vs. 0.70; p = 0.002) and of BCRP mRNA in patients with MLL-PTD (0.61 vs. 0.38; p = 0.03). In univariate analysis, the high expression of MDR-1 mRNA (≥0.1317) negatively influenced the outcome of induction therapy (p = 0.05), whereas the high expression of BCRP mRNA (≥1.1487) was associated with a high relapse rate (RR) (p = 0.013). We found that the high expression of MDR-1 (≥0.1317), MRP-1 (≥0.8409), and BCRP mRNA (≥1.1487) significantly influenced disease-free survival (DFS; p = 0.059, 0.032, and 0.009, respectively) and overall survival (0.048, 0.014, and 0.059, respectively). Moreover, a high expression of BCRP mRNA (≥1.1487) proved to be an independent prognostic factor for RR (p = 0.01) and DFS (p = 0.002) in multivariate analysis. The significant correlation between the expression of MDR-1, MRP-1, and BCRP mRNA and FLT3-ITD or MLL-PTD in AML patients requires further investigation.

  8. Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia

    Directory of Open Access Journals (Sweden)

    Hoeksema KA

    2011-09-01

    Full Text Available Kimberley A Hoeksema1, Aarthi Jayanthan1, Todd Cooper2, Lia Gore3, Tanya Trippett4, Jessica Boklan6, Robert J Arceci5, Aru Narendran11Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, AB, Canada; 2Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA; 3Center for Cancer and Blood Disorders, Children's Hospital, University of Colorado Denver, Aurora, CO, USA; 4Memorial Sloan-Kettering Cancer Center, New York, NY, USA; 5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA; 6Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USAAbstract: Despite significant progress made in the overall cure rate, the prognosis for relapsed and refractory malignancies in children remains extremely poor. Hence, there is an urgent need for studies that enable the timely selection of appropriate agents for Phase I clinical studies. The Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC is systematically evaluating libraries of known and novel compounds for activity against subsets of high-risk pediatric malignancies with defined molecular aberrations for future clinical development. In this report, we describe the in-vitro activity of a diverse panel of approved oncology drugs against MLL-rearranged pediatric leukemia cell lines. Agents in the Approved Oncology Drug Set II (National Cancer Institute/National Institutes of Health Developmental Therapeutics Program were evaluated by in-vitro cytotoxicity assays in pediatric acute lymphoblastic leukemia and acute myeloid leukemia cell lines with MLL gene rearrangements. Validation studies were carried out with patient leukemia cells in culture. Comparative analysis for toxicity against nonmalignant cells was evaluated in normal bone marrow stromal cells and normal human lymphocytes. Results from this study show that 42 of the 89 agents tested have

  9. Saladus on tagasi / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2002-01-01

    Kogupere ulmefilm "E.T. - sõber kaugelt" ("E.T. The Extra-Terrestrial") : režissöör Steven Spielberg : Ameerika Ühendriigid 1982. Restaureeritud ja paari omal ajal välja jäetud stseeniga täiendatud uusversioon

  10. Hirm valitseb Marimaad / Jaak Prozes

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2005-01-01

    Fenno-Ugria hõimukeskuse juhataja sõnul toimub Marimaal arveteõiendamine nendega, kes toetasid presidendivalimiste kampaanias Leonid Markelovi vastaskandidaati, samuti ei sallita neid, kelle arvamus presidendi omaga kokku ei lange. Vägivallajuhtumitest

  11. Tampere ja Unt / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2003-01-01

    Ülevaade 5.-9. märtsini toimunud Tampere 33. lühifilmide festivalist. Riho Undi nukufilm "Hing sees" sai animafilmide žürii diplomi. Võistluskavas minifilmide seas osales ka Priit Pärna joonislaast "Liiga hilja" ("2 Late")

  12. Kliendihaldus toob efektiivsuse / Jaak Ennuste

    Index Scriptorium Estoniae

    Ennuste, Jaak

    2003-01-01

    Kliendihaldustarkvara (CRM) efektiivsus sõltub selle kasutamise ulatusest organisatsioonis. Kliendihaldustarkvara turuliider SalesLogix. Põhilised probleemid kliendisuhtluses. Joonis: Kliendiinfo liikumise skeem

  13. Perm neelas komid / Jaak Prozes

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2004-01-01

    Permikomi autonoomse ringkonna ühinemisest Permi oblastiga. Autori arvates viitab ühinemisprotsess ühemõtteliselt uuele kujunevale Venemaa rahvuspoliitikale, etniliste eripärade tasalülitamisele

  14. Vereplekid punasel vaibal / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    2009-01-01

    62. Cannes'i festivali filmidest : Pedro Almodovari "Katkirebitud embused" ("Los abrazos rotos"), Lars von Trieri "Antikristus" ("Antichrist"), Quentin Tarantino "Vääritud tõprad" ("Inglourious Basterds")

  15. Palmioks kriitilisele realismile / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestivali võitjad. Kuldse Palmioksa võitis Ken Loachi mängufilm "Tuul, mis sasib odrapõldu" ("The Wind That Shakes the Barley"), Grand Prix' sai prantslase Bruno Dumonti film "Flandria" ("Flandres"), parim režissöör oli Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja auhinna sai grupp näitlejannasid Pedro Almodovari filmist "Tagasipöördumine" ("Volver") ja meesnäitleja auhinna sai samuti grupp näitlejaid prantsuse filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi filmile "Punane tänav" ("Red Road")

  16. Hetki suvisest teatriuputusest / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2008-01-01

    Lühidalt suvelavastustest "Wargamäe Wabariik", "Ruja", "Keiserlik kokk", "Vahepeatus", "Pikk päevatee kaob öösse", "Ma olen iseenda naine", "Džinnimäng", "Klaver", "Romeo ja Julia", "Rasputin", "Ohver", "Ernesaks ja Oamats"

  17. Korruptsiooni bioloogilised juured / Jaak Rebane

    Index Scriptorium Estoniae

    Rebane, Jaak

    1999-01-01

    Kuritarvitusele aitavad viia inimese teatud omadused, nagu egoism, piiratus, ahnus, jultumus, tarbimismentaliteet, tõusiklikkus. Korrumptantsaab varumistungi ajel ebaeetilisest käitumisest hoopis positiivse emotsiooni

  18. Animafilminduse algusotsast 1 / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    Maailma esimestest animafilmidest : Albert Smith'i "The Humpty Dumty Circus" (USA, 1898), esimene joonisfilm "Naljakate nägude humoorikad ilmed" (Humorous Phases of Funny Faces") - looja Stuart Blackton (USA, 1906). Esimese joonisseriaali kangelase Fantosche'i lõi Prantsusmaal 1909.a. Emile Cohl

  19. Meelelahutus on meelelahutus / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    17. mail esilinastus Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard). Filmi linastuse järel toimunud pressikonverentsist, kus olid kohal nii lavastaja kui staarid ja rekordarv ajakirjanikke

  20. Esimene avalik filmiseanss / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    Thomas Alva Edisoni kinetoskoobi patendi omandamise ebaseseaduslikkusest : Gordon Hendricks oma raamatus "Edisoni filmimüüt" tõestavat, et autorlus pidanuks kuuluma William Kennedy Laurie Dicksonile (1860-1935)

  1. Lisandusi postkolonialismi diskussioonile / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2011-01-01

    Et Eesti oli Nõukogude okupatsiooni koloniseerimise ohver, tuleks eesti kunsti ajaloo uurimisel lähtuda postkolonialistlikule teooriale omastest lähenemisviisidest ja mõistetest, mis võimaldaksid juba tuntud tõsiasju uutmoodi tõlgendada ning selgitada meie ajalugu ja kultuuri rahvusvahelisele üldsusele. Kolonialismi tunnustest ja levikust Ida-Euroopas 20. sajandil ning mõjudest eesti kunstile, postkolonialismi teooriast ja selle rakendustest

  2. Archaeological investigations on the site of the cistercian nunnery of st. Michael / Mauri Kiudsoo, Irita Kallis

    Index Scriptorium Estoniae

    Kiudsoo, Mauri

    2005-01-01

    2004. aasta suvel Tallinnas Suur-Kloostri 2 kinnistul toimunud kaevamistest. Leidis kinnitust hüpotees, mille kohaselt hävitati kloostri rajamisel mingi varasem asustusvorm. Arheoloogilise stratigraafia analüüsil ja fikseerimisel kasutati Edward C. Harrise koostatud stratigraafia teooria ja metoodika põhimõtteid ja nn. Harrise maatriksit

  3. The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial

    Science.gov (United States)

    Marks, David I.; Moorman, Anthony V.; Chilton, Lucy; Paietta, Elisabeth; Enshaie, Amir; DeWald, Gordon; Harrison, Christine J.; Fielding, Adele K.; Foroni, Letizia; Goldstone, Anthony H.; Litzow, Mark R.; Luger, Selina M.; McMillan, Andrew K.; Racevskis, Janis; Rowe, Jacob M.; Tallman, Martin S.; Wiernik, Peter; Lazarus, Hillard M.

    2013-01-01

    The biology and outcome of adult t(4;11)(q21;q23)/MLL-AFF1 acute lymphoblastic leukemia are poorly understood. We describe the outcome and delineate prognostic factors and optimal post-remission therapy in 85 consecutive patients (median age 38 years) treated uniformly in the prospective trial UKALLXII/ECOG2993. The immunophenotype of this leukemia was pro-B (CD10NEG). Immaturity was further suggested by high expression of the stem-cell antigens, CD133 and CD135, although CD34 expression was significantly lower than in t(4;11)-negative patients. Complete remission was achieved in 77 (93%) patients but only 35% survived 5 years (95% CI: 25–45%); the relapse rate was 45% (95% CI: 33–58%). Thirty-one patients underwent allogeneic transplantation in first remission (15 sibling donors and 16 unrelated donors): with 5-year survival rates of 56% and 67% respectively, only 2/31 patients relapsed. This compares with a 24% survival rate and 59% relapse rate in 46 patients who received post-remission chemotherapy. A major determinant of outcome was age with 71% of patients aged <25 years surviving. Younger patients had lower relapse rates (19%) but most received allografts in first complete remission. In conclusion, multivariate analysis did not demonstrate an advantage of allografting over chemotherapy but only five younger patients received chemotherapy. Prospective trials are required to determine whether poor outcomes in older patients can be improved by reduced-intensity conditioning allografts. NCT00002514 www.clinicaltrials.gov PMID:23349309

  4. Arvo Järvet / Jaak Jaagus

    Index Scriptorium Estoniae

    Jaagus, Jaak, 1956-

    2005-01-01

    23. aprillil 2004. a. kaitses Arvo Järvet Tartu Ülikoolis doktoritööd "Influence of hydrological factors and human impact on the ecological state of shallow Lake Võrtsjärv in Estonia" ("Hüdroloogiliste tegurite ja inimtegevuse mõju madala järve ökoseisundi kujunemisele Võrtsjärve näitel")

  5. Tuntud tundmatud Ungari filmid / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Sõpruse kinos kestab 25. oktoobrini filmiprogramm "Vabaduse tuuled" Ungari 1956.a. ülestõusule pühendatud mängufilmide programm (6 ungari filmi aastaist 1965-2004) : Ungari Instituudi, kino "Sõprus" ja PÖFFi koostööprojekt. Lähemalt Peter Bacso komöödiafilmist "Tunnistaja" (1969) ja Miklos Jancso filmist "Lootuseta" (1965)

  6. Kombates elu ja kunsti piire / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2011-01-01

    Serbia kunstniku Marina Abramovići loomingu näitus New Yorgi Moodsa Kunsti Muuseumis MoMa 2010. aasta kevadel. Näitus "Art Must Be Beautiful. Marina Abramovići valitud teosed" Tartu Kunstimuuseumis 13. novembrini 2011. Performance-kunsti ajaloost

  7. Arhitekti rolli muutused Rootsis / Jaak Poom

    Index Scriptorium Estoniae

    Poom, Jaak

    1996-01-01

    Arhitekt ئ tellija usaldusmees (1945-1950). Elamuehitus saab peamiseks ülesandeks (1950-1960). Miljoniprogramm (1960-1970). Arhitekt ühiskonna põlu all (1970-1980). Postmodernismja turumajandus (1980-1990). Tänapäev ja tulevik (1990-?).

  8. Kunstiorganisatsioonide tasalülitamine / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2013-01-01

    Eesti Nõukogude Kunstnike Liidu loomise järel saadeti laiali senised kunstnike vabatahtlikud organisatsioonid ja rühmitused. Institutsionaalsed ümberkorraldused aitasid kunstnikkonda tasalülitada

  9. Laste ja kunsti nimel / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2003-01-01

    Beliini 53. filmifestivali Kuldkaru sai briti režissööri Michael Winterbottomi "Siin maailmas" ("In this World"), Hõbekaru läks ameerika filmile "Adaptatsioon" ("Adaptation" : režissöör Spike Jonze), parima lavastaja Hõbekaru sai prantslane Patrice Chereau filmi "Tema vend" ("Son frere") eest. Lisatud tähtsamate auhindade saajate nimekiri

  10. Kas surm koos pensioniga? / Jaak Aab

    Index Scriptorium Estoniae

    Aab, Jaak, 1960-

    2007-01-01

    Ilmunud ka: Harju Ekspress, 14. sept. 2007, lk. 4; Lääne Elu, 22. sept. 2007, lk. 2; Põhjarannik, 15. sept. 2007, lk. 2; Severnoje Poberezhje, 15. sept. 2007, lk. 2; Võrumaa Teataja, 15. sept. 2007, lk. 2; Vooremaa, 15. sept. 2007, lk. 2; Meie Maa, 14. sept. 2007, lk. 2; Valgamaalane, 18. sept. 2007, lk. 2; Virumaa Teataja, 20. sept. 2007, lk. 15; Koit, 20. sept. 2007, lk. 6. Parlamendiliige, keskerakondlane kritiseerib Reformierakonna ettepanekut tõsta pensioniiga

  11. Kunstiteose-essee kunstiteaduslikust aktuaalsusest / Jaak Tomberg

    Index Scriptorium Estoniae

    Tomberg, Jaak, 1980-

    2010-01-01

    Walter Benjamini esseest "Kunstiteos oma mehhaanilise reprodutseeritavuse ajastul" (1936), mis näitab kuidas uued reproduktiivsed tehnikad raputavad kunstivalla kõige sisimat tuuma, tühistades kunsti kogu senise "eelloo". Selle aktuaalsusest ka nüüdisajal ja mõjust rahvusvahelistes teoreetilistes aruteludes kunstiteose nüüdisaegse olemuse üle, tema staatuse üle uue meedia keskkonnas

  12. Piirid tugevnevad segases maailmas / Kristjan Jaak Kangur

    Index Scriptorium Estoniae

    Kangur, Kristjan Jaak

    2002-01-01

    6. Pimedate Ööde Filmifestivalil näidatud filme : Prantsusmaa - Palestiina - Maroko - Saksamaa "Jumalik sekkumine" (režissöör Elia Suleiman), Sloveenia - Saksamaa "Piiri valvur" (režissöör Maja Weiss) ja Austraalia "Eraldustara" (režissöör Phillip Noyce)

  13. Palmovaja vetv - krititsheskomu realizmu / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestivali võitjad. Kuldse Palmioksa võitis Ken Loachi mängufilm "Tuul, mis sasib odrapõldu" ("The Wind That Shakes the Barley"), Grand Prix' sai prantslase Bruno Dumonti film "Flandria" ("Flandres"), parim režissöör oli Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja auhinna sai grupp näitlejannasid Pedro Almodovari filmist "Tagasipöördumine" ("Volver") ja meesnäitleja auhinna sai samuti grupp näitlejaid prantsuse filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi filmile "Punane tänav" ("Red Road")

  14. Kuldne Palmioks Rumeenia realismile / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    60-nda Cannes'i filmifestivalist, auhinnasaajatest, eelkõige Kuldse Palmioksa saanud Christian Mungiu filmist "Neli kuud, kolm nädalat ja kaks päeva" (Rumeenia), Kadri Kõusaare "Magnuse" osalemisest. Lisatud auhinnasaajate nimekiri

  15. Pickwick teatrilaboris / Berk Vaher, Jaak Tomberg

    Index Scriptorium Estoniae

    Vaher, Berk, 1975-

    2000-01-01

    Brian D. Barnesi ühemeheteatri etendusest "The Pickwickians at Manor Farm" (Charles Dickensi romaani "Pickwick klubi paberid" ainetel) Tallinna Linnateatris 18. okt. ja Tartu Teatrilabori majas 20. okt

  16. UNICA festivalilt Hollandis / Jaak Järvine

    Index Scriptorium Estoniae

    Järvine, Jaak

    2000-01-01

    Filmiamatööride 62. rahvusvahelisest festivalist Roemondis Hollandis "UNICA 2000", kus žürii avalikule istungile pääses ka tallinlase Karmo Kaasiku "Loot(d)us sureb viimasena" ja UNICA filmiarhiivi valiti Tallinna Kanutiaia Noortemaja stuudio mängufilm "Aleksandra". 63. festival toimub järgmisel aastal Tallinnas

  17. Unenägude isaisad / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2000-01-01

    13.-30.augustini linastub Tallinna Linnaarhiivi hoovis, Pärnu Chaplini kunstikeskuse terrassil ja Haapsalu piispopilinnuse siseõuel 1920. aastate 6 saksa tummfilmi üldpealkirjaga "Türannide galerii". Lühidalt filmidest

  18. Teel tagasi laste juurde / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2005-01-01

    Cannes'i 58. filmifestivalilt : Jean-Pierre ja Luc Dardenne'i "Laps" ("L'Enfant"), Jim Jarmuschi "Murtud lilled" ("Broken Flowers"), Wim Wendersi "Ära tule koputama" ("Don't Come Knocking"), Michael Haneke "Varjatud" ("Cache")

  19. Saksa okupatsioon [1941-44] / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2013-01-01

    Natsionaalsotsialistlik kunstiideoloogia ja -poliitika. Natsionaalsotsialistliku kunsti propaganda. Kunstielu korraldus. Kunstiharidus. Kunstimuuseumid. Näitused ja kunsti rahastamine. Kunstikriitika. Maalikunst

  20. Väljavalituse tunne / Jaak Kilmi

    Index Scriptorium Estoniae

    Kilmi, Jaak, 1973-

    2005-01-01

    Lühihinnang IX Pimedate Ööde Filmifestivali mängufilmidele - "Garpastum" : režissöör Aleksei German jun : Venemaa 2005, "Kohe paradiisi" ("Paradise Now") : režissöör Hany Abu-Assad : Holland - Saksamaa - Prantsusmaa 2005, "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005, "Kolmel ajal" ("Three Times") : režissöör Hou Hsiao-hsien : Taiwan - Hiina 2005

  1. Lühifilmid internetis / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2000-01-01

    Mika Salmi internetifirma Atom Films, kes on 8.-12. märtsini toimuva 30. Tampere rahvusvahelise lühifilmifestivali üks sponsoreid, tegeleb lühifilmide tutvustamise ja turustamisega interneti kaudu

  2. Ot Kannskogo festivalja kruzhitsja golova / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2008-01-01

    Cannes'i 61. filmifestivalist, lähemalt Woody Alleni filmist "Vicky, Cristina, barcelona ja võistlusprogrammi avafilmist "Pimedus" (režissöör Fernando Meirelles). Ka Veiko Õunpuust, kes on saabunud Euroopa talendi auhinda vastu võtma

  3. Hooaeg New Yorgis / Jaak Rähesoo

    Index Scriptorium Estoniae

    Rähesoo, Jaak, 1941-

    1999-01-01

    Joseph Chaikini, Samuel Becketti ja Sam Shepardi näidendite lavastused. Ameerika teatriuuendajate Richard Foremani ja Lee Breueri lavastustest. Järg vt. nr. 3, lk. 33-40, 96; nr. 4, lk. 33-42; nr. 5, lk. 37-45

  4. Voitka-filmi esilinastus / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2004-01-01

    Inglase Daniel Elliotti Eestis tehtud lühimängufilm "Fender Bender" sai Tampere lühifilmide festivalil maineka Prix UIP (United International Pictures) Tampere auhinna. Samal festivalil toimus Pekka Lehto tõsielufilmi "V.O.I.T.K.A. - Metsa vennad" maailmaesilinastus. Erkki Määttäneni "Järveehitaja" portreteeris Leigo järvemuusikakontsertide korraldajat Tõnu Tamme

  5. Žanr : suvelavastus? / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2007-01-01

    Kahekümnest suvisest teatriõhtust: Carlo Gozzi "Ronk" Tallinna Linnateatri lavaaugus (lavastaja Elmo Nüganen), Komöödiateatri suvetuuri lavastus "Elu parim puhkus" (lavastaja Ago-Endrik Kerge), muusikal "Tutvumiskuulutus" (lavastaja Mait Malmsten), Bernard Kangermanni laulumäng "Naabri Mari" (lavastaja Margus Vaher) ja Mara Zalite "Sirelikassid" (lavastaja Peeter Tammearu) Ugalas, Paul Barzi komöödia "Võimalik kohtumine" (lavastaja Raivo Trass) Vanemuise teatri suvelavastus Muhumaal Pädaste mõisas, muusikaline estraadietendus "Tähtede sadu", Endla "Tsirkus!!!" Paikuse-Reiu vabaõhulaval (autor ja lavastaja Tiit Palu), Andrus Kivirähki näidend "Uljas Neitsi" Laulasmaa Resort' rannametsas (lavastaja Taavi Teplenkov), Marti Kivastik "Eesti asi" (lavastaja Ingomar Vihmar) MTÜ Ühendus R.A.A.A.M. Viinistu kunstimuuseumi vabaõhulaval, Emajõe Suveteatri suvelavastus "Jumalaema kiriku kellamees" Victor Hugo romaani järgi (lavastaja Andres Dvinjaninov), "Muna EÜE ehk Viimane kava" (autor Lauri Vahtre, lavastaja Andrus Vaarik) Suure Munamäe vabaõhulaval, Aino Kalda "Reigi õpetaja" Kuressaares (lavastaja ja dramatiseerija Aare Toikka), Vana Baskini Teateris Pierre Chesnot "Kes aevastas?" (lavastaja Eino Baskin), Eduard Vilde romaani "Prohvet Maltsvet" ja vene kirjaniku Viktor Pelevini romaani aineil sündinud lavastus "Proffet" Albu vallas Kukenoosi rehealuses (lavastaja Mart Koldits), Enn Vetemaa "Roosiaed" Raasiku vallas Kiviloo mõisas (lavastaja Eva Klemets), Jim Ashilevi "Portselansuits" (lavastaja Lauri Lagle) Eesti Teatriliidu saalis, Andres Keili "Rooside sõda" Leigo Järveteatris (lavastaja Tõnu Lensment), Võru Teatriateljee suvelavastus Madis Kõivu "Castrozza ehk illusionist" (lavastaja Taago Tubin), Villu Tamme "Haned võlgu" (lavastaja ja kunstnik Jaanika Juhanson) Teatrilabor Von Krahli teatris

  6. Paar maitsvat metsamarja eesti filmiajakirjandusloost / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    2009-01-01

    Ajalehes Vaba Eesti ilmunud mõningatest filmipublitsistikat ja -kriitikat käsitlevatest artiklitest: Eino Tubin "Abstraktne film" (VE, 1962 nr. 2) ja "Mõte ja meedium" (VE, 1962, nr. 6), Mardi Valgemäe "Cannes'i filmipidustused ja Ingmar Bergman" (VE 1960, nr. 7), Ivo Iliste "Tuhk ja teemant" (VE 1960, nr. 1) ja "Ons armastus võimalik" (VE 1960, nr. 5)

  7. Menu hind on valu? / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2004-01-01

    Mõtisklusi "Mosfilmis" 1984 valminud mängufilmi "Menu" ainetel, mis kujutab teatri köögipoolt. Sellega seoses arutleb autor lavastaja- ja näitejatöö üle, kunstinõukogude koosolekute osast lavastuse vastuvõtul, teatritöö eetikast

  8. Harri Taliga - sotside uljas luugimees / Jaak Aab

    Index Scriptorium Estoniae

    Aab, Jaak, 1960-

    2006-01-01

    Töötajate usaldusisiku seaduse eelnõust ja ametiühingute rollist töötajate huvide kaitsmisel. Kommentaar artiklile: Taliga, Harri. Tankistist minister pistis pea luugist välja // SL Õhtuleht 20. mai 2006, lk. 8. Sama ka Põhjarannik 26. mai 2006, lk. 2 ; Meie Maa 27. mai 2006, lk. 2, pealkiri kujul : Harri Taliga - uljas tankist ; Hiiu Leht 30. mai 2006, lk. 2 ; Nädaline 20. juuni 2006, lk. 3

  9. Suveprojekt - igalt teatrilt korraga. II / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    1997-01-01

    Anton Hansen Tammsaare - Margus Kasterpalu 'Tõde ja õigus', lavastanud Andres Noormets (Ugala suvelavastus Vargamäel). Charles Dickensi 'Nicholas Nickleby elu ja seiklused', lavastanud Georg Malvius (Eesti Draamateatris)

  10. Propaganda rahva raha eest / Jaak Juske

    Index Scriptorium Estoniae

    Juske, Jaak, 1976-

    2006-01-01

    Keskerakond on enda ülistamisel maksumaksja raha eest kaotanud igasuguse mõõdutunde, kirjutab autor. Tema sõnul pole Tallinnas ilmuvad 9 ajalehte mõeldud võimuerakonna propagandaks ning Tallinna linna palgal on üle 20 pressi- ja avaliku suhete nõuniku, neist suurem osa on Keskerakonnaga seotud

  11. Loetud tunnid viienda Potterini / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2003-01-01

    J. K. Rowlingi "Harry Potter and the Order of the Phoenix" ("Harry Potter ja Fööniksi ordu") paisatakse müüki 21. juunil; samast päevast saab ka eestikeelset väljaannet tellida, mis ilmub oktoobris, ka reklaaamikampaaniast USAs

  12. Ilusad pildid, mis jagavad teadmisi / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2006-01-01

    Rmt.: Koppel, Donald. Ma hoidsin neid sulle: (I saved them for you) : fotosid eestlastest II maailmasõjas 1943-1944. Tartu : Tartu Kõrgem Kunstikool, 2006 ; Tervitusi Haapsalust : postkaarte ja fotosid Rein Meistri ja Läänemaa Muuseumi kogust. Tallinn : Eesti Entsüklopeediakirjastus, 2006 ; Kuldmuna 2004 : Eesti reklaamiauhinnad. Tallinn : ADC Eesti, 2006

  13. Vene teatri eliit Eestisse / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2009-01-01

    Venemaa teatrifestivalist "Kuldne mask", pikemalt sügisel 6.-13. okt. Eestis mängitavatest lavastustest - Alvis Hermanise "Šukšini lood" Jevgeni Mironoviga peaosas, Aleksandr Ostrovski "Äike" Lev Erenburgi lavastuses, "Onukese unenägu" Oleg Basilašviliga peaosas ja William Shakespeare'i "Kaheteistkümnes öö" Declan Donnellani lavastuses

  14. Eesti väärib paremat / Jaak Aaviksoo

    Index Scriptorium Estoniae

    Aaviksoo, Jaak, 1954-

    2006-01-01

    Ilmunud ka: Virumaa Teataja, Põhjarannik, Severnoje Poberezhje, Meie Maa, Vooremaa 3. okt. lk. 11,2,2,2,2, Sakala, Pärnu Postimees, Sõnumitooja 4. okt. lk. 2,15,2, Lõunaleht 5. okt. lk. 2, Kuulutaja, Vali Uudised 6. okt. lk. 6,2, Järva Teataja 7. okt. lk. 2. Autori sõnul on Eestis tajutav usalduskriis, mille põhjuseks on eetiliste piiride kadumine meie poliitilistest otsustest. Ta toob välja kolm arenguprioriteeti riigi edasiseks arenguks

  15. Tax on corporate transactions in Estonia: overview / Jaak Siim

    Index Scriptorium Estoniae

    Siim, Jaak, 1976-

    2012-01-01

    Dividendide õiguslikest alustest, muudest kasumieraldistest, maksuvabastustest ja tulumaksust tehtavatest mahaarvamistest. Dividendide ümberkvalifitseerimisest muuks tuluks ning tulumaksu arvestamisest ja tasumisest

  16. Trier ühitab unelmaid reaalsusega / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2000-01-01

    Neljanda Pimedate Ööde Filmifestivali avab 3. detsembril Tallinnas Sakala Keskuse suures saalis Lars von Trieri "Pimeduses tantsija" ("Dancer in the Dark"). Filmist räägivad artikli autor ja režissöör ajakirjale Film Comment (5/2000) antud intervjuu kaudu

  17. Nullist sündinud filmid / Jaak Kilmi

    Index Scriptorium Estoniae

    Kilmi, Jaak, 1973-

    2005-01-01

    Sõpruse kinos toimus 1.-6. aprillini "Manifesti filminädal ehk Kuidas nad maailma sündisid", kus näidati TPÜ filmi ja video filmitudengite "Ground Zero" projekti raames valminud lühifilme-kursusetöid. Autor analüüsib eraldi 9 filmi

  18. Vana hea nõukogude kvaliteet / Jaak Kilmi

    Index Scriptorium Estoniae

    Kilmi, Jaak, 1973-

    2002-01-01

    SRÜ ja Baltimaade 11. filmifestivalil Anapas programmi "Avatud videoööd" koostaja muleid ja hinnanguid festivalilt. Parima meesnäitleja preemia sai Rain Simmul Nika osa eest Arvo Iho mängufilmis "Karu süda", žürii märkis ära Mark Soosaare 8-minutilise "La Paloma", "Avatud videoööde" peapreemia sai Mikk Ranna "Sääsk ja hobune". Festivali parimaks filmiks kuulutati Igor Minajevi "Kuumaastikud" ("Lunnõje poljanõ"), mille peaosatäitja Alissa Bogart sai parima naisnäitleja preemia

  19. Iidamast ja Aadamast ehk "Ahvide planeet" / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2001-01-01

    Taas on ekraanile jõudnud Pierre Boulle'i raamatu ainetel "Ahvide planeet" ("Planet of the Apes") : režissöör Tim Burton : Ameerika Ühendriigid 2001. Autor võrdleb seda 1968.a. filmiga ning Ain Kaalepi näidendiga "Iidamast ja Aadamast"

  20. Keskerakondlik hävitustöö / Jaak Juske

    Index Scriptorium Estoniae

    Juske, Jaak, 1976-

    2007-01-01

    Ilmunud ka: Põhjarannik, 7. märts 2007, lk. 2; Järva Teataja, 8. märts 2007, lk. 2; Nädaline, 8. märts 2007, lk. 4; Sakala, 8. märts 2007, lk. 2; Virumaa Teataja, 8. märts 2007, lk. 11; SL Õhtuleht, 8. märts 2007, lk. 12; Harjumaa, 9. märts 2007, lk. 2; Vali Uudised, 9. märts 2007, lk. 2; Lääne Elu, 10. märts 2007, lk. 2. Tallinna linnavolikogu SDE juhi sõnul jäävad Sakala keskuse varemed sümboliseerima keskerakondlikku kultuuripoliitikat

  1. Vorm on see iva, sisu kahjuks - kooruke / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2004-01-01

    57. Cannes'i filmifestivali võistluskavas nähtud neli filmi - John Nosseiteri dokumentaal "Mondovino" (USA), Pedro Almodovari "Halb haridus" (Hispaania), Emir Kusturica "Elu on ime" (Jugoslaavia/Prantsusmaa), Hirokazu Koreeda "Ükski ei tea" (Jaapan)

  2. Kuidas Udmurdi ja Mordva vabariik lipud said / Jaak Prozes

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2008-01-01

    Kunstnikud Juri Lobanov ja Andrei Aljoshkin räägivad Udmurdi vabariigi ja Mordva vabariigi lipu ja vapi saamisloo. Udmurdi ja Mordva lipu värvide tähendusest. Udmurtia, Mordva, Komi ja Marimaa esimene kaasaegse kunsti näitus "Põhi ja kirre : kontinentaalne alateadvus" Kumu Kunstimuuseumis 14. märts-18. mai 2008

  3. Fenno-Ugria Asutus : sidepidaja sugulasrahvastega globaalpoliitika kiuste / Jaak Prozes

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2007-01-01

    Soome-ugri hõimuliikumise keskuse Fenno-Ugria ajaloolisest arengust ning selle initsiatiivil korraldatud üritustest. Vt. samas: Soome-ugri ja samojeedi rahvaste arvukus Venemaal; Soome-ugri ja samojeedi autonoomiad Venemaa Föderatsioonis

  4. GDA sinu abimees pakendil / Piret Jaaks ; kommenteerinud Elena Burm

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2010-01-01

    Euroopa Komisjoni kokku kutsutud toitumisteadlaste komisjoni Eurodiet poolt koostatud GDA toitumisjuhist toiduainepakenditel, mis aitab jälgida toote- või joogiportsjoni osatähtsust päevasest soovitatavast kalorite ning olulisemate toitainete kogusest

  5. Seebiooper, seks ja söömine / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestival. Filmidest : Pedro Almodovari "Volver" ("Naasta"), Lou Ye "Suvepalee", György Palfi "Taxidermia", John Cameron Mitchelli "Shortbus", Richard Linklateri "Rämpstoidu rahvas". Filmiturul on Eesti filmidest edukaim "Leiutajateküla Lotte"

  6. Sügavast kurgust peegeldub terve ajastu / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Dokumentaalfilm "Sügavas kurgus" ("Inside Deep Throat") : režissöörid Fenton Bailey, Randy Barbato : Ameerika Ühendriigid 2005. Film käsitleb 1972.a. kurikuulsa pornofilmi "Sügav kurk" ("Deep Throat") fenomeni

  7. Vabaduse Risti vennad : surnud, kuid mitte unustatud / Jaak Pihlak

    Index Scriptorium Estoniae

    Pihlak, Jaak

    2008-01-01

    Detsembris 2005 ilmus ajakirjanduses üleskutse "Vabaduse Risti vennad - Eesti Wabariigi eliit", millele olid lisatud 361 teadmata saatusega Vabaduse Risti kavaleri nimed. Selle üleskutse tulemusena selgus 176 mehe saatus

  8. Jaak Adamson - ainuke Eesti kodanik Slovakkias / Anneli Ammas

    Index Scriptorium Estoniae

    Ammas, Anneli, 1962-

    2003-01-01

    Maalikunstnik lahkus Eestist 23 aastat tagasi. Elab Alam-Tatrates väikeses külakeses. Kastellaanimaja galerii näitus "Lahtilagunemine. Lennufragmendid" on inspireeritud Slovakkia eraldumisest Tšehhi küljest

  9. Uue majanduse lätteil / Jaak Valge

    Index Scriptorium Estoniae

    Valge, Jaak

    2003-01-01

    Sisemajanduse kogutoodangu mõistest ja arvutusmetoodikast, rahvamajanduse arvepidamise kujunemisest erinevates riikides, elatusmaksumusindeksist (tarbimishinnaindeks) ja rahvastiku elatusaladest. Lisatud tabelid: rahvamajanduslik sissetulek Eestis aastatel 1928-1930 ; tootmisalade puhastoodang aastatel 1929-1938 ; rahvamajanduse kogutoodangu maht turuhindades (miljonites 1960. a. USA dollarites); rahvamajanduse kogutoodangu maht ühe isiku kohta jooksvates hindades ning tabelid Eesti elatusmaksumusindeksi ja rahvastiku jaotuse kohta elatusalade järgi

  10. Cannes'i klassikud - tuntud headuses / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestival. Nähtud filmidest : soomlase Aki Kaurismäki "Agulituled" ("Laitakaupungin valot"), hispaanlase Pedro Almodovari "Volver" ("Naasta"), inglase Ken Loach'i "Kesva heljutab tuul" ("The Wind that Shakes the Barely"), ameeriklase Richard Linklateri "Rämpstoidu rahvas" ("Fast Food Nation")

  11. Cannes'i üllatused / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestivali võitjad. Kuldne Palmioks läks Ken Loachi mängufilmile "Kesva heljutab tuul" ("The Wind That Shakes the Barley"), Grand Prix' sai Bruno Dumonti "Flandria sõdalased" ("Flandres"), parim režissöör - Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja - näitlejannad Pedro Almodovari filmist "Naasta" ("Volver"), parim meesnäitleja - grupp näitlejaid filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi psühholoogilisele draamale "Punane tänav" ("Red Road")

  12. Saalomon ja Raul / Jaak Jõerüüt

    Index Scriptorium Estoniae

    Jõerüüt, Jaak, 1947-

    2010-01-01

    Raul Meele näitus Genti ülikooli raamatukogus 20.04.- 28.05.2010. Kunstniku kunstnikuraamat üheteistkümnes keeles: Meel, Raul. Salomon's Song of Songs = Saalomoni Ülemlaul / kujundanud Tiit Jürna. Tallinn, 2010

  13. Cannes'is algas viimane vaatus / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2006-01-01

    Cannes'i filmifestival. Nähtud filmidest : Alejandro Gonzalez Inarritu "Paabel" (peaosas Brad Pitt), belglase Lucas Belvaux' "Nõrgema õigus", prantslase Bruno Dumonti "Flandria sõdalased" ("Flandres"). Filmiturul on Eesti filmidest edukaim "Leiutajateküla Lotte"

  14. Kunst ja glamuur ulatavad käe / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2005-01-01

    Cannes'i 58. filmifestival toimub 11.-22. maini. Võistluskavast, esilinastustest (George Lucas'e "Tähesõdade" värske osa) ja žüriist, mida juhib Emir Kusturica. "Režissööride kahe nädala" kavas on ka leedulase Šarunas Bartase "Seitse nähtamatut meest". Võistluskava 20 filmi hulgas pole dokumentaal- ja animafilme

  15. Stiilne action igale maitsele / Jaak Kilmi ; interv. Tiit Tuumalu

    Index Scriptorium Estoniae

    Kilmi, Jaak, 1973-

    2006-01-01

    Filmirežissöör juhendas Eesti Kunstiakadeemia magistrantidele dokumentaalfilmist loenguid pidades nende dokfilmide tegemist, mille tulemusena valmis mitu filmi, mis koondatud programmiks "Stiilne action" ja tuleb ettekandmisele Von Krahli teatri kinos

  16. Kolm debüüti / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2001-01-01

    Arvustus: Afanasjev, Vahur. Kandiline maailm. Tartu : Irboska Teataja Kirjastus, 2000 ; Ehin, Kristiina. Kevad Astrahanis : luuletusi 1992-1999. Tallinn : Huma, 2000 ; Kaldmaa, Jüri. Passioon. Tallinn : Huma, 2000

  17. Kui nuustakulased Berliinis käisid / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    57. Berliini filmifestivali peaauhinna Kuldkaru sai Hiina režissööri Wang Quanani film "Tuya abielu" ("Tuya de hun shi"). Ka teistest auhinnasaajatest. Kokkuvõte festivalist ja eestlastest festivalil

  18. Norra-Eesti Selts 25 aastat / Jaak Kiviloog

    Index Scriptorium Estoniae

    Kiviloog, Jaak

    2011-01-01

    Tutvustatakse Norra-Eesti Seltsi 25. tegevusaasta tähistamiseks välja antud norrakeelset koguteost: Estland og Norge i fortid og nåtid : norsk-estisk forening 25 år. Oslo : Norsk-estisk forening, 2010

  19. Füüsikute aasta / Jaan Aarik, Jaak Kikas

    Index Scriptorium Estoniae

    Aarik, Jaan, 1951-

    2014-01-01

    2014. aasta Nobeli füüsikapreemia pälvisid Jaapani teadlased efektiivsete sinist valgust kiirgavate valgusdioodide eest, Nobeli keemiapreemia pälvisid ühiselt sakslane ning ameeriklased ülilahutusega fluorestsents mikroskoopia arendamise eest

  20. 'Tom & Viv' ehk Elulugu kunstiks / Jaak Rähesoo

    Index Scriptorium Estoniae

    Rähesoo, Jaak, 1941-

    1996-01-01

    Mängufilm Thomas Stearns Eliotist Michael Hastingsi näidendi põhjal, stsenaristid Michael Hastings ja Adrian Hodges, re̓issöör Brian Gilbert : Suurbritannia, 1994. Ka autori suhtumisest Madis Kõivu ja Jaan Krossi biograafilistesse teostesse. Järg: 26. jaan., lk. 12

  1. 58. "Berlinale" lõppmäng / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2008-01-01

    Berliini 58. filmifestivali auhinnasaajatest : Kuldkaru võitis Brasiilia produtsendi ja režissööri Jose Padilha mängufilm "Eliitrühm", Hõbekaru USA režissööri Errol Morrise dokfilm "Tavaprotseduur". Parima režissööri Hõbekaru läks Paul Thomas Andersonile mängufilmi "Veri hakkab voolama" eest. Parima näitleja auhinna said Sally Hawkins ja Reza Naji, Alfred Baueri auhinna sai Fernando Eimbcke "Tahoe järv"

  2. Kuldse Maski lavastusi peab vaatama minema / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2011-01-01

    Teatrifestivalist "Kuldne Mask Eestis", mille avab Rimas Tuminase lavastus "Tuul mühiseb paplites". Konstantin Bogomolovi lavastusest "Hundid ja lambad", Lev Ehrenburgi lavastusest "Vassa Železnova", Mindaugas Karbauskise lavastusest "Viik kestab silmapilgu" (põhineb I. Merase romaanil "Igavene tuli")

  3. Auhindu Eesti noortele filmiautoreile / Jaak Järvine

    Index Scriptorium Estoniae

    Järvine, Jaak

    1999-01-01

    Eesti tudengite ja filmiharrastajate edust Varssavis peetud 17. rahvusvahelisel noorte filmifestivalil "Up to 21" ja Venemaal Luugas toimunud 4. rahvusvahelisel lühifilmide festivalil ja 3. noorte filmi-videofoorumil

  4. Söö, joo, vaata filme / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    57. "Berlinale" esimese poole filmidest: Olivier Dahani "Elu on roos" ("La Mome") Edith Piafist, Robert De Niro "Hea karjane" ("The Good Shepherd"), Clint Eastwoodi "Kirjad Iwo Jimalt" ("Letters from Iwo Jima"), Wang Quanani "Tuya abielu", Stefan Ruzowitsky "Võltsijad" ("Die Fälscher")

  5. Milline on edukas teatri ja lavastuste kommunikatsioon? / Piret Jaaks

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2015-01-01

    Kommunikatsioonist Eesti teatrites. Kogemusi jagavad Kristo Kruusman Rakvere teatrist, Kätlin Sumberg Teatrist NO99, Ruudu Raudsepp Linnateatrist, Eveli Loorents Endla teatrist, Hannele Känd Nukuteatrist, Herkko Labi Von Krahli teatrist ja väiketeater Cabaret Rhizome

  6. Linnakeskkonna agenda : Stockholm - poolt ja vastu / Jaak Poom

    Index Scriptorium Estoniae

    Poom, Jaak

    2004-01-01

    Rootsi valitsuse moodustatud linnaplaneerimise ja -ehitamise komitee andis 2003. a. välja "Linnakeskkonna agenda", mis võtab kokku linna planeerimise positiivse kogemuse. Stadsmiljöradet'i linnaehituspõhimõtted. Linnaarenduspoliitikast, J. Poom agenda soovitustest, linnaplaneeringust eesrindlikult planeeritud Stocholmi linnaosa näite varal

  7. Stalinismi kolmas laine [1949-55] / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2013-01-01

    Pärast märtsiküüditamist. Kodanlike natsionalistide ja formalistide paljastamine. Sotsialistliku teooria venestamine. Kunstnike Liidu "puhastamine". Kunstihariduse tsentraliseerimine. Kunstimuuseumid. Maalikunst.

  8. Whole exome sequencing reveals a MLL de novo mutation ...

    Indian Academy of Sciences (India)

    article/fulltext/jgen/094/04/0755-0758 ... University of Messina, Messina, 98123, Italy; National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, United Kingdom; The Portland Hospital for Women and Children, London, W1W 5AH, ...

  9. Dialoog on parem kui monoloog : "Õhtulehe" lugejate küsimustele vastab Tallinna linnapea Jaak Tamm / Jaak Tamm ; interv. Linda Järve

    Index Scriptorium Estoniae

    Tamm, Jaak

    1995-01-01

    Linnakodanike küsimused linnapeale. Tallinna linnaprobleemid. Järgneb 2. mai 1995, lk. 7; 9. mai 1995, lk. 7; 17. mai 1995, lk. 7; 22. mai 1995, lk. 7; 26. mai 1995, lk. 7; 6. juuni 1995, lk.7; 14. juuni 1995, lk. 7; 26. sept. 1995, lk. 12; 2. okt. 1995, lk. 5; 16. okt. 1995, lk. 5; 4. dets. 1995, lk. 5; 11. dets. 1995, lk. 5; 18. dets. 1995, lk. 5. Ilmunud ka: Vetshernii Kurjer, 24. apr. 1995, lk. 3, 2. mai 1995, lk. 3;9. mai 1995, lk. 3; 18. mai 1995, lk. 3; 24. mai 1995; lk. 3; 26. mai 1995, lk. 3; 1. juuni 1995, lk. 3; 3. juuni 1995, lk. 3; 7. juuni 1995, lk. 3; 14. juuni 1995, lk. 3; 21. juuni 1995, lk.3

  10. Enhancer-associated H3K4 monomethylation by trithorax-related, the drosophila homolog of mammalian MLL3/MLL4

    NARCIS (Netherlands)

    H.-M. Herz (Hans-Martin); M. Mohan (Man); A.S. Garruss (Alexander); K. Liang (Kaiwei); Y.-H. Takahashi (Yoh-hei); K. Mickey (Kristen); O. Voets (Olaf); C.P. Verrijzer (Peter); A. Shilatifard (Ali)

    2012-01-01

    textabstractMonomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancers. Although in yeast all H3K4 methylation patterns, including H3K4me1, are

  11. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

    DEFF Research Database (Denmark)

    Starnes, Linda M; Su, Dan; Pikkupeura, Laura M

    2016-01-01

    Class switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B-cell genome. Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transacti...

  12. Eesti amatöörfilmile pronksmedalid / Jaak Järvine

    Index Scriptorium Estoniae

    Järvine, Jaak

    2001-01-01

    Eesti filmiamatöörid said Oslo amatöörfilmide festivalil neli pronksmedalit. Filmid valmisid kahes noortestuudios : Meksvideo (juhendajad Marina Naaber ja Igor Glazistov) ning Kanutiaia Noortemaja videostuudio (juhendaja Pjotr Perelmuter)

  13. Kuuekümnes Cannes'i filmifestival alustas rullumist / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    Algas 60. Cannes'i filmifestival. Pikemalt avafilmist - Wong Kar-Wai "My Blueberry Nights", festivali ajaloost ja korraldusest, eestlaste osalemisest (K. Kõusaar filmiga "Magnus", filmiturul "Klass" ja "Sügisball")

  14. Suveteater kui bränd ja trend. Teatrisuvi 2006 / Jaak Allik

    Index Scriptorium Estoniae

    Allik, Jaak, 1946-

    2006-01-01

    Suvelavastustest: "Vargamäe kuningriik" A. H. Tammsaare "Tõe ja õiguse" I ja V osa ainetel Endla teatri ja Rakvere Teatri ühisprojekt Vargamäel (lavastaja Jaanus Rohumaa), Urmas Lennuk "Koidula" Emajõe Suveteatris (lavastaja Andres Dvinjaninov), "Romeo & Julia" Eesti Nuku- ja Noorsooteatris (lavastaja Andres Dvinjaninov), Andrus Kivirähk "Sürrealistid" Viinistus (lavastaja Hendrik Toompere jun), Mart Kivastik "Kits viiuli ja õngega" Viinistus (lavastaja Raimo Pass), Jaan Kross "Vastutuulelaev" Naissaarel (lavastaja Aleksander Eelmaa), Alfred Jarry "Kuningas Ubu" Teater NO99 Haapsalu Kiltsi lennuvälja angaarides (lavastajad Ene-Liis Semper ja Tiit Ojasoo), Mart Laar ja Lauri Vahtre "Minust jäävad ainult laulud" Munamäe nõlval (lavastaja Tõnu Lensment), A. H. Tammsaare - H. Rekkor "Tõde:ei:õigus" Vargamäe aidas (lavastaja Helen Rekkor), Rudolf Reiman "Painaja" Leigo Järveteatris (lavastajad Jaan Tooming ja Anne Türnpu), Brian Friel "Kodukoht" Eesti Draamateater Keila-Joa mõisas (lavastaja Priit Pedajas), A. Tshehhov - P. Tammearu "Kolm klaasikest kirsiviina" Ugala tiigi kaldal (lavastaja Peeter Tammearu), Jaan Tätte "Kaev" Tallinna Linnateatri siseõues (lavastaja Indrek Sammul), Jim Ashilev "Nagu poisid vihma käes" Endla teater Muuseumiaidas (lavastaja Andres Noormets)

  15. Romaanid võistu rebimas - August Jakobsonist Sass Hennoni / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2005-01-01

    2004. a. romaanivõistluse esikoharomaan on Sass Henno "Mina olin siin", teine koht: Olavi Ruitlane "Kaval-Peeter ja Vene-Pagan", kolmas koht: Meelis Friedenthal "Kuldne aeg". Sisaldab võitjate nimekirja 1979-2004 ja andmeid noorte silmapaistvate autorite kohta: Kaarel Kressa, Toomas Verrev, Priit Kruus, Rolf Liiv, André Trinity, Jana Lepik,

  16. Apollo külastajate lemmikuks on Jan Kausi ja David Mitchelli raamatud / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2006-01-01

    Apollo kaupluse koduleheküljel valiti parimaks ilukirjandusteoseks Jan Kausi "Tema", tõlgitud ilukirjanduse osas David Mitchelli "Pilveatlas", luuleraamatutest Ott Arderi "Luule sünnib kus sünnib kui sünnib" ja lasteraamatutest Christopher Paolini "Vanem"

  17. Tallinnas täpselt nagu saja aasta eest / Jaak Juske

    Index Scriptorium Estoniae

    Juske, Jaak, 1976-

    2004-01-01

    Ilmunud ka: Lääne Elu, 14. okt. 2004, lk. 2; Nädaline, 14. okt. 2004, lk. 4; Koit, 14. okt. 2004, lk. 6; Vooremaa, 14. okt. 2004, lk. 2; Meie Maa, 14. okt. 2004, lk. 2; Hiiu Leht, 15. okt. 2004, lk. 2; Pärnu Postimees, 19. okt. 2004, lk. 15; Sotsiaaldemokraat, nr. 97, okt. 2004, lk. 6. Sotsiaaldemokraatliku Erakonna Tallinna piirkonna esimees pealinna võimu seotusest Toompeaga ja selle otsesest mõjust kogu Eestile

  18. Fiktsiooni nõrk messianistlik jõud : luhtumiselt lunastusele / Jaak Tomberg, Jüri Lipping

    Index Scriptorium Estoniae

    Tomberg, Jaak, 1980-

    2007-01-01

    Kirjatöö lähtub Walter Benjamini (1892-1940)"Ajaloofilosoofilistest teesidest", seob need Eric Santneri (1955), Maurice Blanchot' (1907-2003), Jacques Derrida (1930-2004) ja Slavoj Zhizheki (1949) mõtetega, näidates selle kaudu tegelikkuse luhtumuslikku loomust ja fiktsiooni lunastavat otstarvet, võttes Christa Wolfi (1929) ja Mati Undi (1944-2005) teosed taustaks. Üritatakse vastata küsimustele, kuidas tuvastada ja kirjeldada võimalikkuste virtuaalset välja ajaloos, kuidas kirjeldada seeläbi fiktsiooni ja kuidas fiktsioon kandub tegelikkuse ontoloogilise konstitueerija rollist üle millekski ajaliseks - aja "loolisuse" ehituskiviks

  19. Film Estonia katastroofist jääb tegelikkusest kaugele / Kristjan Jaak Kangur

    Index Scriptorium Estoniae

    Kangur, Kristjan Jaak

    2001-01-01

    Kavandatavast katastroofifilmist "Baltic Storm", mis on ajendatud väidetest, et parvlaev "Estonia" uputati. Stsenaristiks on saksa teleajakirjanik Jutta Rabe, kes koos advokaat Kaj Holmbergiga lõi selleks puhuks stuudio Top Story. Peaosalisi mängivad Greta Scacchi (41) ja Jürgen Prochnow (60)

  20. Mari sangari päeva sõnum / Jaak Prozes ; interv. Livia Viitol

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2006-01-01

    Fenno-Ugria Hõimukeskuse juhataja ja Eestimaa Rahvaste Ühenduse juht soome-ugri rahvaste olukorrast Venemaal ja rahvusseltside tegevusest Eestis. Aprilli lõpul tähistasid marid oma rahvuspüha - mari sangari päeva. Pärimuse põhjal langes maride rahvuskangelane Boltu̧ võitluses oma rahva vabaduse eest 26. aprillil 1556

  1. Talunik Ruusamäe : riik peab abistama Rapla Dairy pankroti ohvreid / Jaak Juske

    Index Scriptorium Estoniae

    Juske, Jaak, 1976-

    2003-01-01

    Võrumaa talunik ja Riigikogu Mõõdukate fraktsiooni liige Rainis Ruusamäe nõuab põllumajandusministrilt, et riik ostaks kokku väikepiimatootjate võlanõuded pankrotis Rapla Dairy vastu, makstes välja võlguoleva raha

  2. Peaminister, aeg on tööle asuda! / Jaak Aab

    Index Scriptorium Estoniae

    Aab, Jaak, 1960-

    2008-01-01

    Ilmunud ka:: Järva Teataja 17. juuli lk. 2, Põhjarannik ja Severnoje Poberezhje 17. juuli lk. 2, Võrumaa Teataja, Meie Maa 19. juuli lk. 2, Vooremaa, Koit 22. juuli lk. 2,6, Vali Uudised 6. august lk. 2. Parlamendiliige kritiseerib peaministrit majandusliku languse süvendamise eest, mille tulemusena halveneb rahva elujärg ja riigist lahkuvad paljud ettevõtjad

  3. Ka suured ettevõtted suudavad kasvada / Koit Brinkmann ; kommenteerinud Mart Brauer, Jaak Kivisild

    Index Scriptorium Estoniae

    Brinkmann, Koit

    2010-01-01

    Gasellide ehk kõige kiiremini kasvanud ettevõtete edetabelit juhtivast Tartu logistikafirmast Transring Tartu OÜ, ettevõtetest Baltic International Trading OÜ, Olerex AS, Viimsi Keevitus AS. Tabel

  4. Eesti amatööridele kuhjaga pronksi / Jaak Järvine

    Index Scriptorium Estoniae

    Järvine, Jaak

    2002-01-01

    Tallinna Kanutimaja noorte amatööride mängufilm "Minu lapsepõlve unenäod" sai Lübecki festivalil pronksmedali ning Oslo festivalil said kolmanda koha Mati Viiuli tõsielufilm "Kaali meteoriit", Tõnu Aru mängufilm "Unenägu" ja Kanutiaia Noortemaja autorite mängufilmid "Kiiremini kui hetk" ning "Mehe töö"

  5. Parandada püksipõlve augu väljalõikamise teel / Jaak Tomberg

    Index Scriptorium Estoniae

    Tomberg, Jaak, 1980-

    2010-01-01

    Arvustus: Saar, Anti. Kuidas sa ära läksid ja mina maha jäin : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2006 ; Saar, Anti. Nemad kaks : [lühiromaan]. Tallinn : Eesti Keele Sihtasutus, 2008 ; Tekste siledast ruumist : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2009

  6. Töö ning pidu Cannes ̀is / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    1998-01-01

    Meeleoludest Cannes ̀i 51. filmifestivalil ja lühidalt Terry Gilliani filmist "Ratastel Las Vegasesse" ("Fear and Loathing in Las Vegas") ning Roberto Benigni filmist "Elu on ilus" ("La Vita é bella")

  7. "A & A" jõulukalender. Helsingi "Armastuse ja anarhia" filmifestival võib pankrotistuda / Jaak Kilmi

    Index Scriptorium Estoniae

    Kilmi, Jaak, 1973-

    2004-01-01

    Helsingi festivalilt "Armastus ja Anarhia". Lähemalt kahest filmist - saksa-türgi režissööri Fatih Akini "Vastu seina" ("Gegen die Wand") ja argentiinlanna Lucrecia Marteli "Püha tüdruk" ("La Nina santa")

  8. Vastuolude sajand matemaatika alustes / Gregory Chaitin ; tõlk. Jaak Lõhmus

    Index Scriptorium Estoniae

    Chaitin, Gregory

    2006-01-01

    Georg Cantori lõpmatute hulkade teooria. Bertrand Russelli loogikaparadoksid. David Hilberti formaalsed aksiomaatilised teooriad. Gurt Gödel avastab mittetäielikkuse. Alan Turing avastab mittearvutatavuse. Juhuslikkusest puhtas matemaatikas

  9. Kinopilte Ameerikast ja DDRist : neljas festivalikiri Euroopa praegusest filmipealinnast Berliinist / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2000-01-01

    Pikemalt mängufilmidest "Mees kui orkaan" : režissöör Norman Jewison : Ameerika Ühendriigid 1999, "Asjatu armuvaev" : režissöör Kenneth Branagh : Ameerika Ühendriigid 1999, "Magnolia" : režissöör Paul Thomas Anderson : Ameerika Ühendriigid 1999 ja "Vaikus pärast lasku" : režissöör Volker Schlöndorff : Saksamaa 1999

  10. Eestlased saadeti Marimaalt segaste põhjendustega välja / Jaak Prozes

    Index Scriptorium Estoniae

    Prozes, Jaak, 1965-

    2005-01-01

    Eesti Kunstiakadeemia poolt korraldatud 28. soome-ugri ekspeditsioon lõppes 17 Kunstiakadeemia tudengi väljasaatmisega Marimaalt kohalike võimude poolt. Lisa: Mõni marikeelne raamat aastas. Vt. samas: Rein Sikk. Suur mees, kes armastab väikseid

  11. Euroopa päeval õhtumaa allakäigust / Jaak Valge

    Index Scriptorium Estoniae

    Valge, Jaak, 1955-

    2012-01-01

    Arvustus: Spengler, Oswald. Õhtumaa allakäik : maailma-ajaloo morfoloogia piirjooned. I köide, Kuju ja tegelikkus ; Õhtumaa allakäik : maailma-ajaloo morfoloogia piirjooned. II köide, Maailma-ajaloolised pespektiivid. Tartu : Ilmamaa, 2012

  12. Saksamaa türklaste võit Berliinis / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2004-01-01

    Berliini 54. filmifestivali Kuldkaru sai saksa mängufilm "Vastu seina" ("Gegen die Wand") : režissöör Fatih Akin. Autori lemmikud olid rootslase Björn Runge "Kui ma vaatan enda ümber" ja korealase Kim Ki-duki "Samariitlanna". Lisatud festivali tähtsamate auhindade saanute nimekiri

  13. Ootuspäraselt, mõne üllatusega / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    2009-01-01

    62. Cannes'i festivali peaauhinna võitis Isabelle Huppert'i juhitud žüriilt Michael Haneke filmiga "Valge pael" ("Das weiße Band"), grand prix' sai prantslase Jacques Audiard'i "Prohvet" ("Un prophete"). Ka teistest auhinnatutest. Lisatud auhinnasaajate nimekiri

  14. Berlinale 2003 : "Lenin" - poeg lavastab ema jaoks Saksa DV edasikestmise / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2003-01-01

    Festivalist, mis toimub loosungi all "Towards tolerance" ja võistluskava filmidest : briti režissööri Michael Winterbottomi "Siin maailmas", sakslase Wolfgang Beckeri absurdikomöödia "Jumalaga, Lenin!" ning Steven Soderberghi "Solaris"

  15. "aeg jookseb kiiresti nagu linnukoer..." : [luuletused] / Jaak Jõerüüt

    Index Scriptorium Estoniae

    Jõerüüt, Jaak, 1947-

    2003-01-01

    Sisu: "aeg jookseb kiiresti nagu linnukoer..." ; "hingele langes lund..." ; Eestis ; "minu esimesed luuletused sündisid siis kui vihma sadas..." ; "mina olen..." ; "kui Rooma jõudsin tabas mind masendus raske koorem langes õlgadele..." ; "Delfis jäi käimata, seal olevat hiilgav genius loci..."

  16. Uue majanduse lätteil : Eesti sisemajanduse kogutoodang aastatel 1923-1938 / Jaak Valge

    Index Scriptorium Estoniae

    Valge, Jaak

    2003-01-01

    Järg nr. 12 lk. 2712-2735. Perekonnastatistika andmetest, investeerimisindeksist, primaar- ja sekundaarsektoris toodetud netoväärtusest ja tööstuse amortisatsioonist. Tabelid. Tertsiaarse ehk teenindussektori netoväärtusest, sisemajanduse kogutoodangu väärtuse leidmisest turuhinnas ja tootmiskontost ning Eesti sisemajanduse kogutoodangust võrrelduna teiste Euroopa riikidega

  17. Cannes'i esimese viispäevaku vaatamismõnu / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Christian Mungiu "Neli kuud, kolm nädalat ja kaks päeva" (Rumeenia) ; Ethan ja Joel Coen'i "Pole maad vanadele meestele" (artikli autoril "Vanadele meestele pole kohta" - "No Country for Old Men" ; Ameerika Ühendriigid), Andrei Zvjagintsevi "Pagendus" (artikli autoril "Maapagu" - "Izgnanije" ; muusika Arvo Pärdilt ; Venemaa)

  18. Coppola kihlvedu saatanaga : Neljas festivalikiri maailma praeguse hetke filmipealinnast Cannes'ist / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2001-01-01

    Cannes'i filmifestivalil linastus sammas 22 aastat tagasi esilinastunud sõjafilmi "Tänapäeva apkalüpsis" ("Apocalypse Now") värskendatud ja algsest 53 minutit pikemaks monteeritud variant : režissöör, stsenarist ja produtsent Francis Ford Coppola : Ameerika Ühendriigid 1979/2001

  19. Teispool punast ja sinist tabletti : virtuaalsus tegelikkuse substantsina / Jaak Tomberg, Jüri Lipping

    Index Scriptorium Estoniae

    Tomberg, Jaak, 1980-

    2006-01-01

    Autorid on lähtepunktiks võtnud Jaan Unduski teose "Maagiline müstiline keel" ja osutavad sellele, kuidas keele ja vaikuse vahelise suhte kaudu on võimalik teadvustada reaalsuse ja virtuaalsuse vahekorda ning transtsedentaalse empirismi kirjeldused Gilles Deleuze'i raamatust "Logique du sens" (1973) ja Slavoj Zhizheki raamatust "Organs Without Bodies" (2004). Eesmärgiks on rajada esmane teoreetiline aluspõhi uueks vaatenurgaks kultuuri- ja fiktsiooniteoreetilistele põhiküsimustele

  20. Edgar Savisaar : peaminister 08.05.1990-29.01.1992 / Edgar Savisaar ; interv. Jaak K. Roosaare

    Index Scriptorium Estoniae

    Savisaar, Edgar, 1950-

    2007-01-01

    Akadeemias Nord erikursuse raames esinenud ekspeaminister Edgar Savisaare poolt käsitletud põhiteemad: peaministriks saamise asjaolud, probleemid peaministriks olemise ajal, õnnestumised ja ebaõnnestumised, hinnang tolleaegsele valitsusele ja pressile, hinnang riigi senisele arengule

  1. "Eesti film 100" tähistamine lepiti kokku / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2005-01-01

    2. juunil, Eesti filmi traditsioonilisel suvepäeval, allkirjastasid seitse filmiga seotud institutsiooni ühiskavatsuste kokkuleppe eesti filmi 100-nda juubeli tähistamiseks 2012. aastal, moodustades koos "Eesti Film 100" algatusrühma

  2. Vahemere Narva-Jõesuu paneb pea pööritama / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2008-01-01

    Cannes'i 61. filmifestivalist, lähemalt Woody Alleni filmist "Vicky, Cristina, Barcelona" ja võistlusprogrammi avafilmist "Pimedus" (režissöör Fernando Meirelles). Ka Veiko Õunpuust, kes on saabunud Euroopa Talendi auhinda vastu võtma

  3. Animeeritud Sookoll ruulib : Kolmas festivalikiri maailma praeguse hetke filmipealinnast Cannes'ist / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2001-01-01

    Huvitavamad seninähtud filmid : täispikk animatsioon "Shrek" : režissöörid Andrew Adamson ja Vicky Jenson : Ameerika Ühendriigid, dokumentaalfilm "ABC Africa" : režissöör Abbas Kiarostami : Iraan ja mängufilm "Päikesevarjutus" ("Kandahar") : režissöör Mohsen Makhmalbaf : Iraan

  4. Kui hästi või halvasti ... / Jaak Aaviksoo, Piret Hartman, Heli Aru

    Index Scriptorium Estoniae

    Aaviksoo, Jaak, 1954-

    2003-01-01

    TÜ rektor J. Aaviksoo, Üliõpilaskondade Liidu juhatuse esimees P. Hartman ja Haridus- ja Teadusministeeriumi kõrghariduse talituse juhataja H. Aru vastavad küsimusele, kui hästi või halvasti on end õigustanud kõrghariduses aasta toiminud 3+2 süsteem

  5. Eesti filmiamatööridele kaks pronksi / Jaak Järvine

    Index Scriptorium Estoniae

    Järvine, Jaak

    2002-01-01

    Luksemburgis 64. ülemaailmsel amatöörfilmide festivalil UNICA 2002 said eestlased kaks pronksmedalit : Daniel Müntinen alias Dan Lead filmi eest "Punapäine päikeseloojang" ja Elen Lotman filmi eest "Homo sapiens". Eesti sai ka teenete eest filmiamatörismi arendamisel UNICA suure kuldmedali. Oktoobris on Tallinnas Balti amatöörfilmide avatud festival

  6. Teisel katsel Riias = Second go-round in Riga / Jaak Jõerüüt

    Index Scriptorium Estoniae

    Jõerüüt, Jaak, 1947-

    2008-01-01

    Eesti suursaadik Lätis, arhitektuurivõistluse žürii liige Riia Eesti saatkonnahoone arhitektuurikonkursist, võidutöödest. Lk. 56-57 Eesti saatkond Riias: I koha pälvinud Lembit-Kaur Stööri, Ülo-Tarmo Stööri ja Heidi Urbi võidutööst, premeeritud tööde plaanid, vaated. II koha said Emil Urbel, Andrus Mark, Ott Hirvesoo ja Peeter Veimer, III koha Juris Mitenbergs, Peteris Suprins, Zane Krumina, Uldis Tucs, Edgars Gribusts ja Edijs Kravalis

  7. Infot saab hallata kõik-ühes portaalitarkvaraga / Jaak Ennuste

    Index Scriptorium Estoniae

    Ennuste, Jaak

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 17. dets. lk. 23. Microsofti poolt turule toodud infoportaali tarkvara SharePoint Portal Server 2003 võimaldab kõiki infotöötlemise protsesse hallata ühes keskkonnas ja on mõeldud eelkõige informatsiooniga töötavatele ettevõtetele. Lisa: Portaali juurutamine ettevõttes

  8. Zehn Oden = Kümme oodi / Kristjan Jaak Peterson ; Deutsch von Gisbert Jänicke

    Index Scriptorium Estoniae

    Peterson, Kristjan Jaak, 1801-1822

    2001-01-01

    Sisu: An Gott ; Sonnenuntergang ; Herbst ; Der Mensch ; Der Mond ; Freundschaft ; Ich muss trinken. Liedchen ; Hoffnung ; Ich bin wieder glücklich ; Der Sänger. Orig.: Jummalale ; Päva loja-minneminne ; Süggise ; Innimenne ; Kuu ; Söbradus ; Ma pean joma. Lauloke ; Lotus ; Ollen jälle önnis ; Laulja

  9. Eesti demokraatlik põrandaalune ja kontaktid Läänega 1970-1985 / Jaak Pihlau

    Index Scriptorium Estoniae

    Pihlau, Jaak, 1937-2014

    2004-01-01

    Dissidentlike rühmituste tegevusest, liiikmetest ja publikatsioonidest. Sisaldab ka tabelit "Vene armee Eestis", kus on ära toodud Vene armee relvaliikide suurus väeliikide järgi (2005, nr. 3, lk. 92) ja kaarti Eesti territooriumil asunud sõjaväeobjektide asukohtade ja arvuga (2005, nr. 3, lk. 94). Järg. nr. 3, lk. 88-98; nr. 4, lk. 94 ; (2005) nr. 1, lk. 101-106 ; nr. 2, lk. 92-99 ; nr. 3, lk. 89-95

  10. Amelie võlus elurõõmuga / Kristjan Jaak Kangur

    Index Scriptorium Estoniae

    Kangur, Kristjan Jaak

    2001-01-01

    Euroopa Filmiakadeemia auhinnatseremooniast. Parim film - prantslaste "Amélie", parim režissöör - sama filmi looja Jean-Pierre Jeunet ning parim operaator Bruno Delbonnel on samuti sama filmi oma. Elutöö auhinna sai koomikute rühmitus Monty Python. Parim naisnäitleja on prantslanna Isabelle Huppert austerlase Michael Haneke filmist "Klaveriõpetaja" ja meesnäitleja Ben Kingsley Suurbritannia-Hispaania ühistöös "Seksikas tõbras". Tiina Loki sõnul näeb enamikku neist filmidest ka praegu käimasoleval Pimedate Ööde Filmifestivalil

  11. Palju vihjeid vihjest ehk alternatiivne tekstianalüüsi õpik / Jaak Rand

    Index Scriptorium Estoniae

    Rand, Jaak

    2005-01-01

    Arvustus: Mihkelev, Anneli. Vihjamise poeetika. Tallinn : Underi ja Tuglase Kirjanduskeskus, 2005.(Collegium litterarum ; 19). Kättesaadav ka võrguteavikuna: http://www.utlib.ee/ekollekt/diss/dok/2005/b17361230/mihkelev.pdf

  12. Mida aastavahetusel kuulatakse : Jõulu TOP 5 / Jaak Ojakäär

    Index Scriptorium Estoniae

    Ojakäär, Jaak, 1958-2016

    1999-01-01

    Viiest populaarsemast jõlulaulust maailmas - "White Christmas" (I. Berlin), "Jingle Bells" (J. S. Pierpoint), "Santa Claus is coming to town" (F. Coots), "Silent Night" (Franz Gruber) ja "Rudolf the red-nosed reindeer" (Johnny Marks). Laulude sünnist, autoritest, esitajatest

  13. On critical art and art criticism in Tartu, sept 2010 / Jaak Tomberg

    Index Scriptorium Estoniae

    Tomberg, Jaak, 1980-

    2010-01-01

    Kaisa Eiche ja Rael Arteli korraldatud Tartu kaasaegse kunsti festivalist (kunstikuust) ja nende koostatud trükisest "ART IST KUKU NU UT 2010". Festivali raames oli Y-galeriis avatud Rael Arteli kureeritud rahvusvaheline näitus "Lisa 6. Nähtamatu käe poliitika". 2. Artishoki biennaalist Tartu Kunstimajas, kuraator Kati Ilves

  14. Luna : [luuletused] / Kristjan Jaak Peterson ; lühibiograafia: S. S. [Svetlan Semenenko

    Index Scriptorium Estoniae

    Peterson, Kristian Jaak, 1801-1822

    1999-01-01

    Sisu: Luna / tlk. Vs. Rozhdestvenski; Druzhba ; Pesnja, slozhennaja v kortshme Tuule po doroge iz Tartu v Rigu, kuda ja otpravilsja navestit rodnõh ; Pesnja Jaaka (on sidit v odinotshestve na gore) / tlk. A. Sokolov ; V den Martina Lutera / tlk. Vs. Rozhdestvenski. Orig.: Kuu ; Sõprus ; Laul, kui ma Tartust läksin Riia poole oma vanemaid vaatama... ; Mardi Lutheruse päeval ; Jaagu laul. Ta istub üksi mäe peal

  15. Eesti Nõukogude Kunstnike Liidu asutamine / Jaak Kangilaski, Juta Kivimäe

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    2013-01-01

    4. jaanuaril 1943 leidis Jaroslavlis aset Eesti Nõukogude Kunstnike Liidu asutamise protseduur. Aasta pärast toimus Moskvas teine peakoosolek (kongress). Kunstilt nõuti sõja ajal teravat poliitilist kihutustööd

  16. Sõjaraamatu hävitamisel on seos Eestiga / Hendrik Vosman, Tuuli Koch ; kommenteerinud Jaak Aaviksoo

    Index Scriptorium Estoniae

    Vosman, Hendrik

    2011-01-01

    Suurbritannia ajakirjaniku Toby Harndeni Afganistani sõda käsitlevast raamatust "Dead Men Risen: The Welsh Guards and the Real Story of Britain's War in Afganistan" ("Ülestõusnud surnud: Walesi kaardivägi ja tegelik lugu brittide sõjast Afganistanis"). Briti kaitseministeerium lükkab ümber Harndeni väite raamatu ümber puhkenud skandaali poliitilisest tagamaast, autori arvates kartis kaitseministeerium, et raamatus leiduv info võiks Eestit ärritada

  17. Cannes'i võidusilmapiir püsib udune / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2008-01-01

    Cannes'i 61. filmifestivalist, lähemalt võistlusprogrammi sotsiaalse suunitlusega filmidest : Clint Eastwoodi "Äravahetamine" ("Changeling") ja Jean-Pierre ning Luc Dardenne'i "Lorna vaikimine" ("Le silence de Lorna")

  18. Nüganen räägib "Marmortahvli" sünniloo / Piret Jaaks

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2003-01-01

    Mängufilm "Nimed marmortahvlil" jõuab nii VHS-kasseti kui DVD-plaadina müügile. Lisaks filmile ilmub DVDl lavastaja Elmo Nüganeni ja mõnede näitlejate poolt kommenteeritud filmiversioon ning Anu Auna dokumentaalfilm filmi tegemisest

  19. Sirbi sari kahe lugupeetud isanda võrra rikkam / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2004-01-01

    Sarjas "Sirbi raamat" ilmusid Johannes Saare ja Ervin Õunapuu esseekogumikud: Õunapuu, Ervin. Öövöö ; déja-vu 1985-2004 ; Saar, Johannes. Päevast päeva : pildikesi ühe rahvusmütoloogia lagunemisest aastail 1993-2004 (Tallinn : Sihtasutus Kultuurileht Sirp, 2004)

  20. Dublini festival II : Külalised. Muust / Jaak Rähesoo

    Index Scriptorium Estoniae

    Rähesoo, Jaak, 1941-

    2002-01-01

    Ka Kopenhaageni Betty Nanseni Teatri näidatud Robert Wilsoni tehtud Georg Büchneri "Woyzecki" tõlgenduse ning noore inglise trupi näidatud Edward Halli lavastatud William Shakespeare "Rose Rage" ("Henry VI") etenduse lavakujundusest ja -kostüümidest.

  1. Rannalapsest tänavakaagiks, tänavakaagist luuletajaks / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2007-01-01

    Arvustus: Elbing, Andrus. Siin beebilõust, tere! Häired pimelinna tänavalt : luuletusi 2004-2006 = Ciao, it's babyface. Trouble from the streets of a blind city : poems 2004-2006 / inglise keelde tlk. Jayde Will. Tallinn : Epifanio, 2006

  2. Säästuajal võidutses sürrealism / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    2010-01-01

    63. Cannes'i filmifestival: Kuldse Palmioksa sai Tai režissöör Apichatpong Weerasethakul oma filmi "Onu Boonmee, kes saab mäletada oma eelmisi elusid" ("Uncle Boonmee Who Can Recall His Past Lives", Tai-Prantsusmaa-Saksamaa-Suurbritannia-Hispaania 2010) eest. Festivalist, teistest auhinnatutest ja huvitavamatest filmielamustest. Festivali žüriid juhtis režissöör Tim Burton

  3. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

    Czech Academy of Sciences Publication Activity Database

    Hanna, C. W.; Taudt, A.; Huang, J.; Gahurová, Lenka; Kranz, A.; Andrews, S.; Dean, W.; Francis Stewart, A.; Colomé-Tatché, M.; Kelsey, G.

    2018-01-01

    Roč. 25, č. 1 (2018), s. 73-82 ISSN 1545-9993 Institutional support: RVO:67985904 Keywords : H3K4 trimethylation Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Biochemistry and molecular biology Impact factor: 12.595, year: 2016

  4. Grand Prix' võitis reklaamfilmistuudio Division / Mait Laas, Jaak Lõhmus, Ants Vist...[jt.] ; interv. Tiiu Leis

    Index Scriptorium Estoniae

    1998-01-01

    Pärnu filmipäevadel 'Do Re Vi' võitis Grand Prix ehk skulptuuri 'Oskar & Ella' reklaamistuudio 'Division', kullatud videokassetid said 'Polarfilm' (dok. film), Martin Pedanik (video) ja Edith Sepp ('Tingimustega Tallinnas'); osalejate M. Laasi, J. Lõhmuse, A. Visti ja I. Raagi kommentaare ürituse kohta;

  5. Väikestest ja suurtest võitjatest : 62. Cannes'i rahvusvahelise filmifestivali auhindadest / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    2009-01-01

    62. Cannes'i festivali peaauhinna võitis Michael Haneke filmiga "Valge pael" ("Das weiße Band"), grand prix' sai prantslase Jacques Audiard'i "Prohvet" ("Un prophete"), parima meestäitja tiitli võitis Christoph Waltz rolli eest Quentin Tarantino filmis "Vääritud tõprad", parima naisosatäitja tiitli võitis Charlotte Gainsbourg rolli eest Lars von Trieri filmis "Antikristus". Lisatud auhinnasaajate nimekiri

  6. Popist Pärdini, Koreast Eestini : Teine festivalikiri maailma praeguse hetke filmipealinnast Cannes'ist / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2001-01-01

    Cannes'i filmifestivali avafilmist, milleks on Baz Luhrmanni muusikal "Moulin Rouge" : Ameerika Ühendriigid 2001. Ka Eestiga seotud seikadest : võistlusprogrammis on prantsuse mängufilm, mille muusika on Arvo Pärdilt, žüriisse kuulub Jaan Ruus ja P. Simmi "Head käed" on filmiturul huvi äratanud

  7. Filmimaailma aplaus realismile : kolmas festivalikiri Cannes'ist, kus filmiprogramm on ületanud ekvaatori / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2002-01-01

    Kolmest seni huvitavamast filmist : inglase Mike Leigh' "Kõik või ei midagi", Michiganist pärit dokumentalisti Michael Moore'i ameeriklaste vägivaldsust uuriv "Keeglimäng enne Columbine'i", iraanlase Abbas Kiarostami "10" ja Kanada armeenlase Atom Egoyani "Ararat"

  8. Aitab jumalateenistust paremini korraldada / Tiiu Pikkur ; kommenteerinud Tiit Salumäe, Jaak Salumäe, Arne Hiob

    Index Scriptorium Estoniae

    Pikkur, Tiiu, 1947-

    2009-01-01

    17. märtsil peeti Tallinna Piiskoplikus Toomkirikus tänujumalateenistus, kus esitleti Eesti luterliku rahvakiriku esimese Eestimaal koostatud ja trükitud liturgiakäsiraamatu - neljaköitelise kirikukäsiraamatu kaht esimest osa: "Jumalateenistuste käsiraamatut" ja "Talituste käsiraamatut"

  9. A de novo Mutation in KMT2A (MLL) in monozygotic twins with Wiedemann-Steiner syndrome.

    Science.gov (United States)

    Dunkerton, Sophie; Field, Matthew; Cho, Vicki; Bertram, Edward; Whittle, Belinda; Groves, Alexandra; Goel, Himanshu

    2015-09-01

    Growth deficiency, psychomotor delay, and facial dysmorphism was originally described in a male patient in 1989 by Wiedemann et al. and later in 2000 by Steiner et al. Wiedemann-Steiner syndrome (WSS) has since been described only a few times in the literature, with the phenotypic spectrum both expanding and becoming more delineated with each patient reported. We report on the clinical and molecular features of monozygotic twins with a de novo mutation in KMT2A. Single nucleotide polymorphism (SNP) microarray was done on both twins and whole-exome sequencing was done using both parents and one of the affected twins. SNP microarray confirmed that they were monozygotic twins. A de novo heterozygous variant (p. Arg1083*) in the KMT2A gene was identified through whole-exome sequencing, confirming the diagnosis of WSS. In this study, we have identified a de novo mutation in KMT2A associated with psychomotor developmental delay, facial dysmorphism, short stature, hypertrichosis cubiti, and small kidneys. This finding in monozygotic twins gives specificity to the WSS. The description of more cases of WSS is needed for further delineation of this condition. Small kidneys with normal function have not been described in this condition in the medical literature before. © 2015 Wiley Periodicals, Inc.

  10. SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance

    DEFF Research Database (Denmark)

    Cruickshank, V Adam; Sroczynska, Patrycja; Sankar, Aditya

    2015-01-01

    the selective requirement for these proteins for leukaemic cell expansion and self-renewal in-vitro as well as in leukaemia. Gene expression profiling in human cells of each of these three factors suggests that they have overlapping functions in leukaemia. The gene expression changes induced by loss...... of the three proteins demonstrate that they are required for the expression of haematopoietic stem cell associated genes but in contrast to previous results obtained in mouse cells, the three proteins are not required for the expression of c-MYC regulated genes....

  11. Testing the potential significance of different scion/rootstock genotype combinations on the ecology of old cultivated olive trees in the southeast Mediterranean area.

    Science.gov (United States)

    Barazani, Oz; Waitz, Yoni; Tugendhaft, Yizhar; Dorman, Michael; Dag, Arnon; Hamidat, Mohammed; Hijawi, Thameen; Kerem, Zohar; Westberg, Erik; Kadereit, Joachim W

    2017-02-06

    A previous multi-locus lineage (MLL) analysis of SSR-microsatellite data of old olive trees in the southeast Mediterranean area had shown the predominance of the Souri cultivar (MLL1) among grafted trees. The MLL analysis had also identified an MLL (MLL7) that was more common among rootstocks than other MLLs. We here present a comparison of the MLL combinations MLL1 (scion)/MLL7 (rootstock) and MLL1/MLL1 in order to investigate the possible influence of rootstock on scion phenotype. A linear regression analysis demonstrated that the abundance of MLL1/MLL7 trees decreases and of MLL1/MLL1 trees increases along a gradient of increasing aridity. Hypothesizing that grafting on MLL7 provides an advantage under certain conditions, Akaike information criterion (AIC) model selection procedure was used to assess the influence of different environmental conditions on phenotypic characteristics of the fruits and oil of the two MLL combinations. The most parsimonious models indicated differential influences of environmental conditions on parameters of olive oil quality in trees belonging to the MLL1/MLL7 and MLL1/MLL1 combinations, but a similar influence on fruit characteristics and oil content. These results suggest that in certain environments grafting of the local Souri cultivar on MLL7 rootstocks and the MLL1/MLL1 combination result in improved oil quality. The decreasing number of MLL1/MLL7 trees along an aridity gradient suggests that use of this genotype combination in arid sites was not favoured because of sensitivity of MLL7 to drought. Our results thus suggest that MLL1/MLL7 and MLL1/MLL1 combinations were selected by growers in traditional rain-fed cultivation under Mediterranean climate conditions in the southeast Mediterranean area.

  12. Rector's office as of 31 December 2005

    Index Scriptorium Estoniae

    2006-01-01

    TÜ rektoraadi koosseis: rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Tõnu Lehtsaar, prorektor prof. Jaak Kangilaski; administratsioonidirektor Mihkel Pärnoja, finantsdirektor Taimo Saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

  13. ROLi juhatuses on ees ootamas suured muudatused / Matis Song

    Index Scriptorium Estoniae

    Song, Matis, 1978-

    2004-01-01

    Raplamaa Omavalitsuste Liidu täiskogul arutluse all olnud olulisematest probleemidest. Vallavanemate kogu esimees, Raikküla vallavanem Jaak Pregel ning ROL-i tegevdirektor Jaak Herodes kavatsevad ametist lahkuda

  14. Pust budet bezoblatshnõm nebo nad Baltiiskim domom / Ella Agranovskaja

    Index Scriptorium Estoniae

    Agranovskaja, Ella, 1950-

    2000-01-01

    Teatrifestivali "Baltiiski dom" nimelise medali "Stroitel Baltiiskogo doma" pälvisid teatrikriitik Eteri Kekelidze, lavastaja Elmo Nüganen, endine kultuuriminister Jaak Allik, Vene Draamateatri direktor Aleksandr Iljin, teatrijuht Jaak Viller ja Kultuuriministeeriumi kantsler Margus Allikmaa

  15. Rektoraat seisuga 31.12. 2005

    Index Scriptorium Estoniae

    2006-01-01

    TÜ rektoraadi koosseis: rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Tõnu Lehtsaar, prorektor prof. Jaak Kangilaski; administratsioonidirektor Mihkel Pärnoja, finantsdirektor Taimo Saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

  16. Andmebaaside õiguslik kaitse Ameerika Ühendriikides : [bakalaureusetöö] / Jaak Parre ; Tartu Ülikool, õigusteaduskond ; juhendaja: Raul Narits

    Index Scriptorium Estoniae

    Parre, Jaak, 1981-

    2003-01-01

    Andmebaaside tähtsusest ja olemusest, praegu eksisteerivad võimalused andmebaaside kaitseks (tehnoloogilised vahendid, autoriõigus, lepinguõigus, Digital Millennium Copyright Act, patendiõigus, kõlvatu konkurents), võimalused tulevikus

  17. Kiirusvastupidavuse arendamisele suunatud treeningukoormuse mõju verenäitajatele / Anatoli Landõr, Jelena Vider, Jaak Maaroos...[jt.

    Index Scriptorium Estoniae

    2002-01-01

    Uuringu eesmärgiks oli määratat jalgratturite kiirusvastupidavuse arendamisele suunatud kehalise koormuse mõju vere näitajatele ja välja selgitada nende muutuste taastumise kiirus ja seda mõjutavad faktorid

  18. Raadiomängud Eestis Teise maailmasõja ajal ja järel. 1.-7. osa / Jaak Pihlau

    Index Scriptorium Estoniae

    Pihlau, Jaak, 1937-2014

    2010-01-01

    Luureoperatsioonidest Teise maailmasõja ajal. Eesti territooriumiga seotud Abwehr'i luuregruppidest ja Eesti alal Teise maailmasõja ajal tegutsenud luurekoolidest. Raadiomängudest (Blind, Sever, Javka jm.). Eestlastest Saksa Soome luureüksustes. Lennuoperatsioone alustamine USA poolt Leetu 1950. aastal. USA ja Briti luurejuhtide kohtumisest Münchenis. Eesti agentide saabumisest Lätti. Briti-Eesti luureagentide saabumisest Eestisse 1952. aastal. Eesti NSV Riikliku Julgeoleku Ministeeriumi poolt alustatud raadiomängust "Universitet", hilisema nimega "Berkut". USA luureoperatsioonidest Leetu ja Eestisse

  19. Jaan Ehlvest soovi(ta)b mudast tõusta / Jaan Ehlvest ; intervjueerinud Valeri Maksimov ; kommenteerivad: Jaak Allik, Valter Heuer, Olav Sepp

    Index Scriptorium Estoniae

    Ehlvest, Jaan, 1962-

    1998-01-01

    Intervjuu Jaan Ehlvestiga olukorrast nii Eesti kui maailma males pärast maleolümpiat Elistas, kus Eesti meeskond jäi 40. kohale ning selle tulemusega ei olnud rahul ei meeskond ega ka Eesti Maleliit

  20. Lehekülgi Eesti lähiajaloost : kuidas ENSV MGB välisluureülem GULAG-i arhipelaagi sattus / Jaak Pihlau

    Index Scriptorium Estoniae

    Pihlau, Jaak, 1937-2014

    2007-01-01

    ENSV julgeoleku koosseisu kuuluva välisluureosakonna funktsioonidest, tegevusest ja agentuurist. Välisluure osakonna ülema asetäitjast Mihhail Škurenkovist (kes tegelikult täitis ülema kohustusi). Pagari tänava sisevanglast tšekistist vangi pilgu läbi. Julgeolekukindral Boris Kummist

  1. Inimese mõõde II. Kuue- ja seitsmekümnendad : kirjanduslooline fragmentaarium 1960.-1970. aastail tegutsenud kirjanikest / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2015-01-01

    Katkendid intervjuudest ja vestlustest Leo Metsariga, Valda Rauaga, Mihkel Rauaga, Enn Vetemaaga, Andres Ehiniga, Väino Ilusaga, Ülo Tuulikuga, Villem Grossiga, Heljo Männiga, Maie Kaldaga, Jaan Isotammega, Vaapo Vaheriga, Jaan Kaplinskiga, Mati Undiga, Vaino Vahinguga, Lea Tormisega, Ralf Parvega, Oskar Kruusiga ja Toomas Vindiga

  2. Inimese mõõde II. Kuue- ja seitsmekümnendad : kirjanduslooline fragmentaarium 1960.-1970. aastail tegutsenud kirjanikest / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2011-01-01

    Katkendid intervjuudest ja vestlustest Leo Metsariga, Valda Rauaga, Mihkel Rauaga, Enn Vetemaaga, Andres Ehiniga, Väino Ilusaga, Ülo Tuulikuga, Villem Grossiga, Heljo Männiga, Maie Kaldaga, Jaan Isotammega, Vaapo Vaheriga, Jaan Kaplinskiga, Mati Undiga, Vaino Vahinguga, Lea Tormisega, Ralf Parvega, Oskar Kruusiga ja Toomas Vindiga

  3. Filmiloo annus mirabilis 1927 ja eesti mängufilm. Taastatud "Noored kotkad" pidulikel kontsertesitlustel ja DVD-levis / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak

    2008-01-01

    Theodor Lutsu tummfilm "Noored kotkad" (1927). Filmile eelnenud ajast, filmi valmimisest, kaastegijatest ning toetajatest. Filmi publikuhuvist, kinoorkestritest, kes filmi erinevates kinodes saatsid. Filmi kajastamisest ajakirjanduses 1927. aastal. Artikli lõpus Theodor Lutsust

  4. Mis on parem - Zaporozhets või Mercedes? / Andres Langemets

    Index Scriptorium Estoniae

    Langemets, Andres, 1948-

    2007-01-01

    Vastukaja Mikko Lagerspetzi artiklile 5. dets. Postimehes, mis oli omakorda vastukaja Jaak Aaviksoo artiklile 19. nov. Postimehes. Sotsioloogiast, sotsiaalteadlastest ja sotsioloogilistest küsitlustest

  5. Dom, kotorõi postroil Iljin / Ella Agranovskaja

    Index Scriptorium Estoniae

    Agranovskaja, Ella, 1950-

    2005-01-01

    Viimased neli aastat on Vene Kultuurikeskuse direktoriks olnud Aleksandr Iljin. Vene Kultuurikeskusest on saanud arvestatav Tallinna kultuurikeskus. Kommenteerivad Riigikogu liikmed Ago-Endrik Kerge ja Jaak Allik

  6. Julgesti, vennad, nüüd tööle : haiglajuht seletab valitsusele, et vajalik palgaraha on haigekassa reservis / Peep Põdder

    Index Scriptorium Estoniae

    Põdder, Peep, 1964-

    2007-01-01

    Jõgeva haigla juhataja kirjutab tervishoiuprobleemidest, pidades tervishoidu esimeseks julgeolekuküsimuseks ning kritiseerides ekssotsiaalminister Eiki Nestori tegevust ja andes nõu sotsiaalminister Jaak Aabile

  7. Перемещение частных пространств = Transporting private spaces / Тоомас Паавер ; интервьюировал Владимир Фролов

    Index Scriptorium Estoniae

    Паавер, Тоомас, 1976-

    2012-01-01

    Tallinna linna tasuta ühistranspordist, transpordisüsteemi puudustest ja arengusuundadest. PAIK Arhitektide (Toomas Paaver, Jaak-Adam Looveer, Lauri Saar) Kristiine terminali projektist, jalgrattateedest

  8. Selgusid Betti Alveri preemia nominendid

    Index Scriptorium Estoniae

    2005-01-01

    Betti Alveri kirjandusauhinna nominendid: Sass Henno "Mina olin siin", Andrei Hvostovi "Lombakas Achilleus", Mart Kanguri, Jaak Ranna ja Ivar Ravi "Jaak Rand ja teisi jutte", Diana Leesalu "2 grammi hämaruseni", Jaan Pehki "Sisukord", Linnar Priimäe "Kelle tee on varjul", Leo de Sixtuse "Skarabeuse tsivilisatsioon". Vt. ka Eesti Päevaleht, 16. nov., lk. 15

  9. Betti Alveri sünniaastapäeval kuulutatakse välja järjekordne Alveri kirjandusauhinna saaja...

    Index Scriptorium Estoniae

    2005-01-01

    Kirjandusauhinna nominendid: Sass Henno. Mina olin siin ; Andrei Hvostov. Lombakas Achilleus ; Mart Kangur, Jaak Rand ja Ivar Ravi. Jaak Rand ja teisi jutte ; Diana Leesalu. 2 grammi hämaruseni ; Jaan Pehk. Sisukord ; Linnar Priimägi. Kelle tee on varjul ; Leo de Sixtus. Skarabeuse tsivilisatsioon

  10. Rõõm Joyce'i raamatuist / Toomas Raudam

    Index Scriptorium Estoniae

    Raudam, Toomas, 1947-

    2003-01-01

    Arvustus: Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003 ; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003

  11. Sepistada oma rahvale süüme / Märt Väljataga

    Index Scriptorium Estoniae

    Väljataga, Märt, 1965-

    2003-01-01

    Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003

  12. Teadlase eetika / Magnus Ilmjärv

    Index Scriptorium Estoniae

    Ilmjärv, Magnus, 1961-

    2008-01-01

    Vastukaja art.: Valge, Jaak. Pätsi riigipööret ei inspireeritud väljastpoolt // Postimees (2008) 26. apr., lk. 13. President Konstantin Pätsi kohta leitud uutest arhiivimaterjalidest. Raamatu "Hääletu alistumine" autor, ajaloolane Magnus Ilmjärv peab Jaak Valge kriitikat tema suhtes põhjendamatult suureks

  13. Cannes südames / Mirkka Maikola

    Index Scriptorium Estoniae

    Maikola, Mirkka

    2011-01-01

    Nicolas Winding Refni filmist "Drive" (USA 2011). Lisaks tegid oma pingerea Cannes´is nähtud filmidest Eesti filmikriitikud ja -tegijad Jaan Ruus, Jaak Lõhmus, Tristan Priimägi, Jaak Kilmi, Andris Feldmanis, Maria Ulfsak-Šeripova ja Laura Talvet

  14. James Joyce kui religiooni subjekt ja objekt / Kalle Käsper

    Index Scriptorium Estoniae

    Käsper, Kalle, 1952-

    2003-01-01

    Arvustus: Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003 ; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003; vt ka vastukaja: Raudam, Toomas. Kontra Käsper // Sirp (2003) 20. juuni, lk. 5

  15. Journey towards yourself / Rein Veidemann

    Index Scriptorium Estoniae

    Veidemann, Rein, 1946-

    2011-01-01

    Arvustus: Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010 ; Luik, Viivi, Rosma, Hedi. Ma olen raamat. Tallinn : SE & JS, 2010 ; Jõerüüt, Jaak. Armastuse laiad, kõrged hooned. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010

  16. Arhiivikonkursi kolm algusaastat (2007-2009) = The First Three Years of the Compatriots Programme’s Archival Competition (2007-2009) / Andero Adamson, Jüri Viikberg, Jaak Viller

    Index Scriptorium Estoniae

    Adamson, Andero

    2010-01-01

    Rahvuskaaslaste programmi arhiivikonkursist projektidele, mis on suunatud väliseesti ajaloolis-kultuurilise pärandi kogumisele, säilitamisele ja kättesaadavaks muutmisele. Konkursi põhimõtetest, konkursile saadetud projektitaotlustest ning projektide hindamiseks loodud ekspertkomisjoni tööst

  17. Ümarlaud: kui pikk on ühe maja elu? = Round-table discussion: how long is the life of a building? / Yoko Alender, Jaak Huimerind, Krista Kodres ...[jt.] ; üles kirjutanud Tüüne-Kristin Vaikla

    Index Scriptorium Estoniae

    2012-01-01

    Ümarlaud Eesti 20. sajandi väärtusliku arhitektuuri säilitamise teemal Tallinna Linnahallis 1. juunil 2012. a. Ümarlaua kutsus kokku 13. Venezia arhitektuuribiennaali Eesti ekspositsiooni kuraator Tüüne-Kristin Vaikla

  18. Paradigma muutus 1970-ndate aastate Lääne kunstis ja selle kajastus eesti kunstielus = The Change of Paradigm in the Western Art of the 1970s and its Reflection in the Estonian Art World / Jaak Kangilaski

    Index Scriptorium Estoniae

    Kangilaski, Jaak, 1939-

    1998-01-01

    Nõukogude võimu ideoloogilisest arengust, eesti kunsti suundumustest okupatsiooni ajal ئ ametlik, rahvuslik-konservatiivne (30.-te ideaalidele toetuv) ja avangardistlik suund ئ ning muutustest eesti kunstis seoses 1970. aastatel lääne kunstis toimunud paradigmade vahetumisega, suhetest vene avangardkunstiga

  19. Complex three-way translocation involving MLL, ELL, RREB1, and CMAHP genes in an infant with acute myeloid leukemia and t(6;19;11)(p22.2;p13.1;q23.3)

    DEFF Research Database (Denmark)

    Tuborgh, A; Meyer, C; Marschalek, R

    2013-01-01

    until progression to acute myeloid leukemia, AML-M5. The leukemic cells harbored a novel apparent 3-way translocation t(6;19;11)(p22.2;p13.1;q23.3). We utilized advanced molecular cytogenetic methods including 24-color karyotyping, high-resolution array comparative genomic hybridization (aCGH) and DNA...... in the initial stages of disease before clear morphological signs of bone marrow involvement. The patient responded well to therapy and remains in remission>6 years from diagnosis. This apparent 3-way translocation is remarkable because of its rarity and presentation with myeloid sarcoma, and may, as more cases...

  20. The “Mystique” of Acute Leukemia: MPAL-BAL-AUL-ALAL-aBLL-HAL-MLL: Initial presentation of MPAL as extramedullary neurological compromise; A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Soubhagya Ranjan Tripathy

    2016-12-01

    Conclusion: For routine neurosurgical practice, these entities are extremely rare; and hence a working knowledge is very essential for appropriate & timely management notwithstanding the neurosurgical desire to rule out the compressive lesions first. Neurological status deterioration may be halted with timely institution of appropriate chemotherapy. In the extensive literature review in pubmed, this may be only the 1st case of MPAL with extramedullary neurological manifestation, at the first clinical presentation.

  1. Comparison of the effects of crude and spent oils on Tilapia ...

    African Journals Online (AJOL)

    Toxic effects of bonnylight crude and spent oils on Oreochromis niloticus fingerlings were conducted under laboratory conditions at the University of Port Harcourt, Nigeria for two months. Five concentrations (5 ml/L, 10 ml/L, 20 m1/L, 50 m1/L and l00 ml/L) of water soluble fraction (WSF) of crude and spent oils were ...

  2. Tretjakova, Alavainu ja Johanson tuuritavad Ida-Virumaal

    Index Scriptorium Estoniae

    2004-01-01

    5. apr. alustavad turneed Ida-Virumaal Ave Alavainu ja Tatjana Tretjakova, et esitleda oma luuleraamatut "2keelsed = 2jazõtshnõje" (Kärdla : A. Alavainu, 2004). Jaak Johanson laulab laule nimetatud autorite tekstidele

  3. Suurim kirjanduslik ja sotsialistlik võistlus / Aarne Ruben

    Index Scriptorium Estoniae

    Ruben, Aarne, 1971-

    2004-01-01

    Eesti kirjanikud Nõukogude Liidus 1920.-1930ndatel, kirjandusajakirjast "Leegid" (ilmus Leningradis a-tel 1926-1936). Ka Jaak Urmeti artiklist "Formalism marksistlikus kirjandusteaduses", Sirp, 2004, 23. apr

  4. Auhind TÜ teadurile

    Index Scriptorium Estoniae

    2014-01-01

    Kirjandusteooria teadur Jaak Tomberg pälvis maailma vanima teadusliku fantastika uurijaid koondava ühingu SFRA (Science Fiction Research Association) ühe oma kahest aastaauhinnast - eelmise aasta parima kriitilise artikli auhinna

  5. Preemiad

    Index Scriptorium Estoniae

    2006-01-01

    Riigi kultuuripreemia 2006 - Jaak Soans. Kultuuripreemia 2005. a. loominguliste saavutuste eest - Krista Kodres, Pekka Vapaavuori. Kultuurkapitali aastapreemiad 2005. Vaala kunstipreemia - Maarit Murka. Parimad "mitmikud". Pikemalt Hansapanga kunstipreemia laureaadist Mark Raidperest ja Massimo Martini Design Award 2006 saanud Pavel Sidorenkost

  6. Plaadid / Kaur Garshnek, Mart Niineste, Tui Hirv...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Tuule Kann/Jaak Sooäär "Õhtu ilu", The Mars Volta "The Bedlam In Goliath", Eva Dahlgren "Petroleum Och Tang", Lenny Kravitz "It's Time For A Love revolution", "Flyleaf ", New Project "Ultraviolent Light"

  7. Nostalgia Pühajärve kaldal / Paavo Kangur

    Index Scriptorium Estoniae

    Kangur, Paavo, 1966-

    2006-01-01

    Edgar Savisaare kunagise üleminekuvalitsuse ministrite kohtumisest Pühajärvel. Vt. samas: Eksriigiministri Raivo Vare toost; Eksmajandusministri Jaak Leimanni anekdoot naistest; Eksharidusminister Rein Loik arvab. Fotod

  8. Dead Men Risen: Estonian defence minister accuses me of 'fiction' and 'does not rule out going to court'

    Index Scriptorium Estoniae

    Harnden, Toby

    2011-01-01

    Raamatu "Dead Men Risen" autor räägib oma blogis Eesti kaitseministri Jaak Aaviksoo ja president Toomas Hendrik Ilvese reageeringutest teosele, kus on juttu ka Afganistanis teeninud Eesti kaitseväelastest

  9. Peeter Allik, Urmas Viik jt Londonis

    Index Scriptorium Estoniae

    2006-01-01

    Eesti, Läti ja Leedu graafikute näitus "Power and Man. Three Countries. One Exhibition" galeriis Novas Gallery. Eestist osalevad Peeter Allik, Urmas Viik, Jaak Visnap, Kadri Alesmaa, Aili Vahtrapuu, Inga Heamägi

  10. Tuul väljal / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

  11. Jaan Klõšeiko soovitab: Jaan Tootseni film "Uus maailm"

    Index Scriptorium Estoniae

    2011-01-01

    Režissöör Jaan Tootsen dokumentaalfilmi "Uus Maailm" (produtsent Jaak Kilmi, Kuukulgur Film, 2011) saamisloost ja filmist, mis valiti 25.-30. oktoobrini Tšehhis toimuvale Jihlava rahvusvahelisele dokumentaalfilmide festivalile

  12. "Keisri hull" kui müstiline fantasy / Siimon Prii

    Index Scriptorium Estoniae

    Prii, Siimon

    2006-01-01

    30. sept. Ugalas esietendunud Jaan Krossi "Keisri hull" (autoridramatiseering), lavastajad Jaak Allik ja Peeter Tammearu. Kunstnik on Jaanus Laagriküll ja muusikaline kujundaja Peeter Konovalov. Peaosas Peeter Tammearu

  13. Professor Peep Veski meie meenutustes

    Index Scriptorium Estoniae

    2014-01-01

    Mälestusi Tartu Ülikooli Farmaatsia instituudi juhatajast Peep Veskist jagavad: Eve-Irene Lepist, Urve Paaver, Karin Kogermann, Kristian Semjonov, Jaak Koppel, Kristin Raudsepp, Imre Klebovich, Filiz Hincal, A. Atilla Hincal ja Elmar Arak

  14. Two-state solutions

    Index Scriptorium Estoniae

    2011-01-01

    16. detsembril Tartus toimunud Eesti-Läti koostöökonverentsist võtsid osa ka mõlema riigi peaministrid Andrus Ansip ja Valdis Dombrovskis. Kohal olid ka haridusministrid Jaak Aaviksoo ja Roberts Kilis

  15. "See õpilasmalev on ikka täitsa tume maa" / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2003-01-01

    Stsenaristide-režissööride Jaak Kilmi ja Rene Reinumägi poolt läbiviidud castingutest filmi "Sigade revolutsioon" peaosaliste leidmiseks, valiti välja õpilased Uku Uusberg, Lilian Alto ja Jass Seljamaa

  16. Kunstiteaduslik doktoritöö EKA-s kaitstud / Ingrid Ruudi

    Index Scriptorium Estoniae

    Ruudi, Ingrid

    2005-01-01

    Heie Treier "Kohalik modernsus kunstis. Eesti varamodernistliku kunsti teoreetiline ja ajalooline kontseptualiseerimine ning Karl Pärsimägi paradigmaleidmise perioodil". Juhendaja Thomas McEvilley, eelretsensent Katrin Kivimaa ja Ene Lamp. Oponent Jaak Kangilaski

  17. Põhjamaise taskuteatmik / Anneli Porri

    Index Scriptorium Estoniae

    Porri, Anneli, 1980-

    2005-01-01

    Põhjamaade Ministrite Nõukogu Sleipniri stipendiaatide tööde näitus "Põhjamaine tunnetus" Eesti Rahva Muuseumis 14. I-27. II Tartu kunstikuu raames. Kuraator Jaak Visnap. Minna Hindi seeriast "Rannastseenid"

  18. Uisutajad tõid presidendiproua kooli / Elina Randoja

    Index Scriptorium Estoniae

    Randoja, Elina

    2011-01-01

    Proua Evelin Ilves ja endine suusataja Jaak Mae külastasid 10. mail 2011 Tartu Katoliku Kooli, kus õpivad tänavuse noore sportlase preemia pälvinud iluuisutajatest õed Nanette Christine ja Naomi Charlotta Andersson

  19. Tom ja Anni ajavad isad-emad naerma / Kai Väärtnõu

    Index Scriptorium Estoniae

    Väärtnõu, Kai

    2007-01-01

    ETV lastesaate "Saame kokku Tomi juures" stsenarist on Jaak Urmet ehk Wimberg. Teksti improviseerivad ka näitlejad Karol Kuntsel ja Maria Soomets. Lisaks tutvustus "Pööningule purjetab proua Õietolmutuust"

  20. Rector's office as of 31 December 2006

    Index Scriptorium Estoniae

    2007-01-01

    Rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Birute Klaas, administratsioonidirektor prof. Mihkel Pärnoja, finantsdirektor Taimo saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

  1. Malbe ja sihikindel Indrek Rahumaa / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2007-01-01

    Indrek Rahumaa suurosalusega investeerimisfond on viimase pooleteise aastaga investeerinud agressiivsesse laienemisse üle kolme miljardi krooni. Vt. samas: CV; Alta Capital tänavu hoogsalt laienenud. Kommenteerivad Eimar Rahumaa ja Jaak Raid

  2. Kohvik Supelsaksad = Supelsaksad Café

    Index Scriptorium Estoniae

    2011-01-01

    Eesti Sisearhitektide Liidu 2010. a. söögikoha interjööri preemia pälvinud kohvikust Supelsaksad Pärnus Nikolai t. 32. Sisekujunduse autorid Anna Huimerind ja Ruth Huimerind. Arhitekt Jaak Huimerind

  3. Inimeselt inimesele? Endalt iseendale. "In Graafika" / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2003-01-01

    7. graafikafestival "IN Graafika". Näitused Pärnu kontserdimajas, Imatra kõrgema kunstikooli väljapanek Academia Gratas, Eesti Litograafiakeskusest (eestvedajad Kadri Alesmaa, Jaak Visnap), kus oli workshop

  4. Balti näitlejad natside ja rüütlite vahel / Aarne Ruben

    Index Scriptorium Estoniae

    Ruben, Aarne, 1971-

    2008-01-01

    Dokumentaal-mängufilm nõukogude sõjafilmides fashiste kehastanud Baltimaade näitlejatest "Fritsud ja blondiinid" : režissöör Arbo Tammiksaar : produtsendid Jaak Kilmi, Askold Saulitis : Eesti - Läti 2008

  5. Seltskond : [fotod] / tekst ja fotod Annika Haas

    Index Scriptorium Estoniae

    2008-01-01

    8. dets. esitles Helle Michelson Eesti Lastekirjanduse Keskuses mälestusteraamatut "Lehitsetud leheküljed: Meenutusi elust ja lastekirjandusest" (Tallinn : Tänapäev, 2008) Kohal viibisid lastekirjanikud Ellen Niit, Jaak Urmet jt.

  6. Eesti filmid võistlevad Rjazanis

    Index Scriptorium Estoniae

    2002-01-01

    Rjazanis 22.-31. maini toimuval festivalil "Zolotoi Vitjaz" on konkursikavas ka Jaak Kilmi ja Andres Maimiku "Päkapikudisko", Hannes ja Renita Lintropi "Läbi pimeduse" ja Peeter Simmi "Elu pärast maailmalõppu"

  7. Nõmme ja Kristiine piirikünkale Järvel kerkib sihvakas torn / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2005-01-01

    Järve keskuse naabrusesse ehitatavast 15-korruselisest büroohoonest, Böckleri majast. Autorid Studio Paralleeli arhitektid Jaak Huimerind ja Indrek Saarepera. Lisaks "Kõrghoonete katusevaated võiksid olla avalikud"

  8. Hea nali võib peituda raamatus / Gert Kiiler

    Index Scriptorium Estoniae

    Kiiler, Gert

    2007-01-01

    Arvustus: Leer, Jaak. Savumees Einaril on kogu aeg buss katki. Tallinn : Jutulind, 2006 ; Huber, Markus, Treichler, Robert. Keegi pole nii vinge kui meie : uimased britid, tobedad sakslased, pinges prantslased ja veel 36 lootusetut juhtumit. Tallinn : Olion, 2006

  9. Ja jälle filmitudengid! Voila! / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2003-01-01

    Tallinna Kinomajas linastunud TPÜ filmi ja video õppetooli operaatorite kursuse II õppeaasta kursusetööd-lühifilmid : "Tulemine" (Elen Lotman), "Duell" (Mart Arjukese, Kristjan-Jaak Nuudi), "Opus Negrum" (Peter Murdmaa) ja "What's the feeling" (Janek Karakatsh)

  10. Matriarhaat või patriarhaat - kas meeste päralt on ainult reede? : "M Klubi" 80! / Ela Tomson ; intervjueerinud Anti Einpaul

    Index Scriptorium Estoniae

    Tomson, Ela, 1945-

    1998-01-01

    Teleseriaal "M Klubi" uuel hooajal, stsenarist Toomas Kall, režissöör Roman Baskin : Baltic Entertainment Company. Võrdlus teiste seriaalidega. Arvamuse ütlesid Ela Tomson, Mati Põldre, Jaak Allik, Eino Baskin

  11. Eesti dokfilm sai Euroopast toetust

    Index Scriptorium Estoniae

    2005-01-01

    Euroopa Liidu MEDIA Plus programm toetab kaht Eesti dokumentaalfilmi projekti : "Maria teatri fantoomid" (Baltic Film Production ; autor Marianna Kaat) ja "Müümise kunst" (Kuukulgur Film ; autorid Andres Maimik, Jaak Kilmi)

  12. Kas hakkas hirm võõrale maale ära kaduda? / Mööna Tilder

    Index Scriptorium Estoniae

    Tilder, Mööna

    2010-01-01

    Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis. Esietendus 9. dets. Tallinna Meistrite Hoovi teatrisaalis

  13. Tantsuline vaade kodusele Eestimaale Aafrikast / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2009-01-01

    9. dets. esietendub Tallinna Meistrite Hoovi teatrisaalis Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis

  14. Ajakirjanikud ajasid metsas hundijälgi / Liisi Seil

    Index Scriptorium Estoniae

    Seil, Liisi, 1971-

    2003-01-01

    Hundiuurija Marko Kübarsepp viis teabepäevast "Elu koos hundiga" osalejad Soomaa metsadesse hundijälgi otsima. Kiskja kohta jagasid veel teavet Tõnu Traks, Ilmar Rootsi, Peep Männil ja Jaak Volmer

  15. Q Vara ehitab tootmismaad laopargiks

    Index Scriptorium Estoniae

    2007-01-01

    Kinnisvarafirma Q Vara OÜ alustab 2007. a. mais Rae vallas Tallinna ringtee ääres asuva 168000 m2 suuruse tootmismaa ümberehitamist laopargiks. Ettevõtte projektijuhi Jaak Puistma sõnul jagatakse laopark 22 krundiks

  16. Aaviksoo vihje : Reivik kaotab töö / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2008-01-01

    Ärisidemete tekkimine Aivar Reiviku juhitava aktsiaseltsi Volta ja Vabadussõja võidusamba ehitaja Sans Souci vahel lõpetab Reiviku lepingu kaitseministeeriumiga. Kommenteerib kaitseminister Jaak Aaviksoo

  17. Vabadussõja võidusammas valmib Tšehhi klaasitehases / Dannar Leitmaa, Urmas Jaagant

    Index Scriptorium Estoniae

    Leitmaa, Dannar, 1982-

    2008-01-01

    Eesti kaitseminister Jaak Aaviksoo ja Tšehhi klaasivabriku Sans Souci esindaja Martin Chab allkirjastasid lepingu, mille kohaselt tšehhid projekteerivad, valmistavad ja püstitavad 15. oktoobriks Tallinna Vabaduse väljakule võidusamba

  18. Filme meist ja meie ajast / Raimo Jõerand

    Index Scriptorium Estoniae

    Jõerand, Raimo

    2007-01-01

    EFSA filmiekspert teavitab uutest eesti tõsielufilmidest : Urmas E. Liivi "Casting" ja "Briljantroheline maja, pumbakaev ja valge laev", Andres Maimiku, Jaak Kilmi "Müümise kunst", James ja Maureen Tusty "Laulev revolutsioon"

  19. Mirovaja kultura s dostavkoi na dom / Ilja Sundelevitsh

    Index Scriptorium Estoniae

    Sundelevitsh, Ilja

    2003-01-01

    Kunstinäitustest Tallinnas. Raul Meele käsikirjaliste tekstide (konkreetne luule) näitus "Kirjutatud lugu/kiri" Kastellaanimaja galeriis ja Jaak Arro segatehnikas inglipildid näitusel "Linnud" Kunstihoone galeriis

  20. Perekond Raus ENSV kaitseliinil / Valdur Ohmann

    Index Scriptorium Estoniae

    Ohmann, Valdur, 1958-

    2015-01-01

    Põhjalikumalt Oskar Rausi ja Viktor Rausi elukäigust. Viktor Rausi seostest tuntud eesti kultuuritegelastega: Jaanus Orgulas, Voldemar Panso, Jaak Joala, Arvo Pärt, Leonhard Lapin, Jüri Arrak, Aarne Vahtra, Heinz Valk, Ott Arder jt.

  1. Dokfilm "Elav jõud" osaleb kahel mainekal festivalil

    Index Scriptorium Estoniae

    2004-01-01

    Andres Maimiku ja Jaak Kilmi dokumentaalfilmi "Elav jõud" on valitud Nyoni (Šveits) festivalile "Visions du Reel" ja Wiesbadenis toimuvale festivalile "goEast - Festival of Central and Eastern European Film"

  2. Uinutav dokumentaaldraama Vene äärmusopositsionääridest / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2009-01-01

    7. jaanuaril esilinastub Tallinna kinos Sõprus dokumentaalfilm opositsionääridest Venemaal "Revolutsioon, mida ei tulnud" (režissöör Aljona Polunina, produtsent Jaak Kilmi; tootjad Kuukulgur Film ja Matila Röhr Productions Soomest, 2008)

  3. Antiputinlaste hingeelu / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    2009-01-01

    Dokumentaalfilmist "Revolutsioon, mida ei tulnud", režissöör Aljona Polunina, produtsendid Jaak Kilmi ja Ilkka Matila, Kuukulgur Film ja Matila Röhr productions, 2008. Esilinastus Eestis kinos Sõprus 7. jaan. 2009

  4. Kino nagu elu, mis on hullemgi veel / Mart Laar

    Index Scriptorium Estoniae

    Laar, Mart, 1960-

    2009-01-01

    Dokumentaalfilmist "Revolutsioon, mida ei tulnud", režissöör Aljona Polunina, produtsendid Jaak Kilmi ja Ilkka Matila, Kuukulgur Film ja Matila Röhr productions, 2008. Esilinastus Eestis kinos Sõprus 7. jaan. 2009

  5. Kolm, keda miski ei seo / Veiko Märka

    Index Scriptorium Estoniae

    Märka, Veiko, 1964-

    2004-01-01

    Arvustus: Jõerüüt, Jaak. Uus raamat : [luuletused]. Tallinn : Tuum, 2004 ; Maiste, Juhan. In Arcadia ego : [luuletused]. Tallinn : J. Maiste, 2004 ; Essa, Maario. Kellegi teise muru : debüütluulekogu. Tallinn : SE & JS, 2004 ;

  6. Poisid on halvad, poisid on head / Oudekki Loone

    Index Scriptorium Estoniae

    Loone, Oudekki, 1979-

    2005-01-01

    Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Kristian Taska, R. Vilbre, produtsent ja operaator Manfred Vainokivi : laulusõnade autor Jaak Urmet : tegevprodutsent Marju Lepp : Parunid ja Vonid, Taska Film, Amrion 2005

  7. Vizit gotovnosti k sotrudnitshestvu

    Index Scriptorium Estoniae

    2008-01-01

    Eestis viibis ametlikul külaskäigul Afganistani kaitseminister Abdul Rahim Wardak, kes kohtus president Toomas Hendrik Ilvesega ja kaitseminister Jaak Aaviksooga ning välisminister Urmas Paetiga. Vt. samas: Abdul Rakim Wardak

  8. Pismo na kamne eto uzhe ne kamennõi vek / Ilja Sundelevitsh

    Index Scriptorium Estoniae

    Sundelevitsh, Ilja

    2003-01-01

    Jaak Visnapi ja Kadri Alesmaa litograafianäitusest "Stonerollers" Tallinna Linnagaleriis, ka litograafia-tehnikast. Briti Nõukogu korraldatud briti eliitdisaini näitusest "POSH" Tallinna Kunstihoone galeriis

  9. August toob Vainupeale kontserte

    Index Scriptorium Estoniae

    2006-01-01

    Kontsertidest Vainupeal: Kunda suvekooli noored saksofonistid 10. aug., Jaan Arder ja Henn Rebane 15. aug., kunstinäituse "Blended X" sulgemiskontsert 19. aug., Silvi Vrait ja Jaak Jürisson 26. augustil

  10. Plaadid / Kaur Garshnek, Ave Randviir, Priit Pruul...[jt.

    Index Scriptorium Estoniae

    2007-01-01

    Uutest heliplaatidest Jaak Sooäär, Raul Vaigla, Tanel Ruben "No99 Jazzklubis", Black Strobe "Burn Your Own Church", The Quantic Soul Orchestra "Tropidelico", Uni "Kosmikud II", Bugge Wesseltoft "IM", Gabrielle "Always"

  11. Kindlustuspakett kui Lego torn / Liina Leiten

    Index Scriptorium Estoniae

    Leiten, Liina

    1999-01-01

    Koduse vara kindlustamise tingimused. Tabelid: 1999.a. 1. kvartali usaldusreiting varakindlustuse osas, valik koduse vara kindlustamise hinnapakkumisi. Kommenteerivad maaklerfirma In Bro & Partners kindlustusdirektor Jaak Rikson ja Kindlustusabi OÜ direktor Toivo Voit

  12. ESTO ühendab kõiki, kes tunnevad endid eestlastena / Kristel Sarrik ; fotod: Vaado Sarapuu; Kristel Sarrik; Karin Rumming

    Index Scriptorium Estoniae

    Sarrik, Kristel

    2009-01-01

    Jaak Juhansoo ja Mart Laanemäe kõnedest, dokumentaalfilmist "Peod täis pisaraid", Kristjan Randalu ja Bodek Janke kontserdist, näitustest, sõjaveteranide kokkutulekust, kirikukonverentsist, kontserdist "Generatsioonid" jpm.

  13. Afganistani draama: mida hukkunud Eesti sõdurite kohta varjata püütakse? / Teet Teder, Maarius Suviste

    Index Scriptorium Estoniae

    Teder, Teet

    2011-01-01

    Toby Harndeni raamatust "Dead Men Risen", kus on juttu ka Afganistanis teeninud Eesti kaitseväelastest. Kaitseminister Jaak Aaviksoo ja president Toomas Hendrik Ilvese reageeringutest. Vt. ka lk. 10: Uudam, Laur. Eetikapomm

  14. Kuumad tantsud ja Donki Hotid Eesti polaaröös / Margit Kask

    Index Scriptorium Estoniae

    Kask, Margit

    2007-01-01

    "Talveöö festival 2006" - "Söör Vantes. Donki Hot", lavastaja Dmitri Krõmov, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu" ja "Linnaelu kataloog" jaapanlase Issei Ogata esituses. Ka Jaak Alliku kommentaar festivalil nähtule

  15. Uus kord tõi nurina / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2010-01-01

    IT-eksperdid Tõnu Samuel ja Jaan Jänesmäe peavad domeenireformi läbikukkunuks ning on koostanud avaliku kirja, milles kritiseerivad Eesti Interneti Sihtasutuse juhte Marek-Andres Kautsi ja Jaak Lippmaad

  16. Peal on propaganda, all on tugev off / Valle-Sten Maiste

    Index Scriptorium Estoniae

    Maiste, Valle-Sten, 1972-

    2008-01-01

    Lõppeva teatriaasta repertuaarivalikust. Teatriaasta õnnestumiste ja ebaõnnestumiste kohta vastavad küsimustele ka Pille-Riin Purje, Jaak Allik, Rein Veidemann, Rait Avestik, Jim Ashilevi, Eva Kübar, Madli Pesti ja Madis Kolk

  17. Rektoraat seisuga 31.12.2006

    Index Scriptorium Estoniae

    2007-01-01

    Rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Birute Klaas, administratsioonidirektor prof. Mihkel Pärnoja, finantsdirektor Taimo saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

  18. Telepoisi kolmas tulemine / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2008-01-01

    ETV lastesaadete esimese telepoisi looja oli 1960. aastatel Jaak Palmse, 2000. aastatel "taastas" telepoisi Meelis Arulepp ja 2008.a. ilmus telepoiss ekraanile Daniel Müntineni ja animatsioonistuudio Birds of Paradise loominguna

  19. Raamatututvustus

    Index Scriptorium Estoniae

    2008-01-01

    2008. a. ilmunud artiklikogumikust "Koht ja paik = Place and location : studies in enviromental aesthetics and semiotics VI" (toimetajad Eva Näripea, Virve Sarapik, Jaak Tomberg), 2007. a. ilmunud Kalju Suure fotoalbumist "Järelhüppeid kultuurikihist. 2"

  20. "Röövlirahnu Martini" nõgesteta Eesti! / Asko Künnap

    Index Scriptorium Estoniae

    Künnap, Asko

    2005-01-01

    Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Jaak Urmet, R. Vilbre jt., produtsent ja operaator Manfred Vainokivi : helilooja Kaspar Jancis : Parunid ja Vonid, Taska Film, Amrion 2005

  1. Mida ihkab mu hing? / Toomas Raudam

    Index Scriptorium Estoniae

    Raudam, Toomas, 1947-

    2003-01-01

    Arvustus: Joyce, James. Pagulased : [näidend] / tõlkinud Jaak Rähesoo. Tallinn : Varrak, 2003. Ilmunud ka: Raudam, Toomas. Väike äratundmiste raamat. Tallinn : Eesti Keele Sihtasutus, 2006. Lk. 124-128

  2. Eesti Pindaros : K. J. Petersoni oodide vaimuloolisest taustast [2] / Jaan Undusk

    Index Scriptorium Estoniae

    Undusk, Jaan, 1958-

    2012-01-01

    Artikli teises osas vaadeldakse täpsemalt Pindarose saksakeelseid jäljendajaid ning jõutakse Tartu ülikooli professori Wilhelm Friedrich Hezeli ja Kristjan Jaak Petersoni kontaktideni nii õpingutes kui loomingus

  3. Vikergallup : eesti kirjandus 2000 : [vastused Vikerkaare küsimustele

    Index Scriptorium Estoniae

    2001-01-01

    Aut.: Epp Annus, Andres Aule, Veiko Belials, Jan Kaus, Andrus Kivirähk, Leo Luks, Hedda Maurer, Anneli Mihkelev, Marko Mägi, Aare Pilv, Jürgen Rooste, Aarne Ruben, Mihkel Samarüütel, François Serpent, Ivar Sild, Karl Martin Sinijärv, Jaak Urmet. 2000. a. parimaks uudisraamatuks tunnistati Andrus Kivirähu "Rehepapp ehk November" ja parimaks esikraamatuks Wimbergi [Jaak Urmet] "Maaaraamat"

  4. PENGARUH PENAMBAHAN EFFECTIVE MICROORGANISM-4 (EM-4 PADA PENGOMPOSAN TERHADAP PRODUKSI JAMUR MERANG

    Directory of Open Access Journals (Sweden)

    Adisti Yuliastrin

    2016-09-01

    Full Text Available This research was aimed for knowing the influence of  EM-4 (effective microorganism-4 addition and the most effective concentration of EM-4 in compost media for straw mushroom (Volvariella volvacea (Bull. ex Fr. Sing production. The treatment examined the use of EM-4 solution divided into six treatments and four repetitions. EM-4 concentration from 0 ml/l – 12,5 ml/l with an interval increasing of 2,5 ml/l. The addition of 7,5 ml/l – 12,5 ml/l concentration of EM-4 did not give so different result with the control media. Composting with addition of 5 ml/l EM-4 gave the highest straw mushroom production (2272,25 g. Statistically the result showed that the concentrations of EM-4 had no significant effect on the mushroom production.

  5. Comparative toxicity of petrol and kerosene to periwinkle ...

    African Journals Online (AJOL)

    The comparative toxicities of two petroleum products, petrol and kerosene were examined by exposing Tympanotonus fuscatus to acute concentrations (60, 90, 120 and 150ml/L) of these toxicants for 96 hours. The 48th hour LC50 for petrol was 177.36 ml/L, while that of kerosene was 306.16 ml/L. The 96th hour LC50 was ...

  6. UJI EFEKTIFITAS INSEKTISIDA NABATI EKSTRAK AKAR TUBA (Derris elliptica B. DAN UMBI GADUNG (Dioscorea hispida D. TERHADAP MORTALITAS DAN PERKEMBANGAN HAMA Plutella xylostella L. DI LABORATORIUM

    Directory of Open Access Journals (Sweden)

    irfan sugiono utomo

    2017-06-01

    Full Text Available Plutella xylostella L. merupakan hama penting tanaman kubis. Hama ini menyerang bagian daun dengan gejala daun menjadi berlubang sehingga turunnya produksi mencapai 80-100% penyebaran hama Plutella xylostella tersebar di daerah tropis dan subtropis.. Penelitian ini dilaksanakan di laboratorium Hama Tumbuhan Jurusan Hama dan Penyakit Tumbuhan Fakultas Pertanian Universitas Jember. Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL dan di uji menggunakan uji Beda Nyata Terkecil (BNT dengan taraf 5%. Perlakuan aplikasi yang digunakan dengan 2 metode, yaitu metode tetes (ulat dan metode celup (pakan. Perlakuan yang digunakan yaitu: K1 (Konsentrasi akar tuba 20ml/l air, K2 (Konsentrasi akar tuba 25ml/l air, K3 (Konsentrasi akar tuba 30ml/l air, K4 (Konsentrasi umbi gadung 20ml/l air, K5 (Konsentrasi umbi gadung 25ml/l air, K6 (Konsentrasi umbi gadung 30ml/l air, K7 (Konsentrasi akar tuba 20 ml/l air +umbi gadung 30ml/l air, K8 (Konsentrasi akar tuba 30 ml/l air +umbi gadung 20ml/l air. Pengamatan meliputi persentase mortalitas larva P. xlostella , persentase larva yang menjadi pupa, persentase larva yang menjadi imago Hasil penelitian menunjukkan bahwa Insektisida nabati akar tuba dan umbi gadung berpengaruh sangat nyata terhadap mortalitas larva Plutella xylostella yakni dapat menyebabkan tingkat mortalitas sebesar 86,67 % dengan konsentrasi paling efektif pada perlakuan K8 yaitu ektrak akar tuba 30ml/l air + umbi gadung 20ml/l air. Perlakuan ekstrak nabati akar tuba lebih efektif dengan metode celup sedangkan ekstrak umbi gadung lebih efektif dengan metode tetes. Penggunaan perlakuan kombinasi insektisida nabati lebih efektif dibandingkan dengan pemberian insektisida nabati tunggal.Kata kunci: Plutella xylostella, Akar tuba, Umbi gadung 

  7. Sectioning of multilayers to make a multilayer Laue lens

    International Nuclear Information System (INIS)

    Kang, Hyon Chol; Stephenson, G. Brian; Liu Chian; Conley, Ray; Khachatryan, Ruben; Wieczorek, Michael; Macrander, Albert T.; Yan Hanfei; Maser, Joerg; Hiller, Jon; Koritala, Rachel

    2007-01-01

    We report a process to fabricate multilayer Laue lenses (MLL's) by sectioning and thinning multilayer films. This method can produce a linear zone plate structure with a very large ratio of zone depth to width (e.g., >1000), orders of magnitude larger than can be attained with photolithography. Consequently, MLL's are advantageous for efficient nanofocusing of hard x rays. MLL structures prepared by the technique reported here have been tested at an x-ray energy of 19.5 keV, and a diffraction-limited performance was observed. The present article reports the fabrication techniques that were used to make the MLL's

  8. Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group.

    Science.gov (United States)

    Spector, Logan G; Davies, Stella M; Robison, Leslie L; Hilden, Joanne M; Roesler, Michelle; Ross, Julie A

    2007-01-01

    Leukemias with MLL gene rearrangements predominate in infants (birth weight, higher birth order, and prior fetal loss have, with varying consistency, been associated with infant leukemia, but no studies have reported results with respect to MLL status. Here, we report for the first time such an analysis. During 1999 to 2003, mothers of 240 incident cases (113 MLL(+), 80 MLL(-), and 47 indeterminate) and 255 random digit dialed controls completed a telephone interview. Odds ratios and 95% confidence intervals for quartile of birth weight, birth order, gestational age, maternal age at delivery, prior fetal loss, pre-pregnancy body mass index, and weight gain during pregnancy were obtained using unconditional logistic regression; P for linear trend was obtained by modeling continuous variables. There was a borderline significant linear trend of increasing birth weight with MLL(+) (P = 0.06), but not MLL(-) (P = 0.93), infant leukemia. Increasing birth order showed a significant inverse linear trend, independent of birth weight, with MLL(+) (P = 0.01), but not MLL(-) (P = 0.18), infant leukemia. Other variables of interest were not notably associated with infant leukemia regardless of MLL status. This investigation further supports the contention that molecularly defined subtypes of infant leukemia have separate etiologies.

  9. Full Multilayer Laue Lens for Focusing Hard X-rays

    International Nuclear Information System (INIS)

    Liu Chian; Shi, B.; Qian, J.; Conley, R.; Yan, H.; Wieczorek, M.; Macrander, A. T.; Maser, J.; Stephenson, G. B.

    2010-01-01

    Multilayer Laue Lenses (MLLs) were developed by us using dynamic diffraction effects to efficiently focus hard x-rays to very small spots. Using a partial MLL we were able to focus 19.5-keV hard x-rays to a line focus of 16 nm with an efficiency of 31%. A full MLL is a complete linear MLL structure. It can be fabricated by bonding two partial MLL wafers, or by growing the full structure using magnetron sputtering without bonding. A 40-μm full MLL, with a total of 5166 layers of WSi 2 and Si, has been successfully grown by sputter deposition. The layer thicknesses gradually vary from 4 nm to ∼400 nm and then back to 4 nm. Two coating runs were used to grow the full structure, one for each half. It took over 56 h for each run. A 100-μm nearly-full MLL was constructed by bonding. Each 50-μm half-structure has 1788 WSi 2 and Si layers with 12-nm to ∼32-nm thicknesses and ∼32-μm total thickness, followed by a thick WSi 2 layer of ∼17 μm, and an AuSn layer of ∼1 μm. Both full MLL structures survived dicing and polishing. The primary results demonstrate the feasibility and potential of a full MLL with a doubled numerical aperture and large beam acceptance for hard x-rays.

  10. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.

    Science.gov (United States)

    Santos, Margarida A; Faryabi, Robert B; Ergen, Aysegul V; Day, Amanda M; Malhowski, Amy; Canela, Andres; Onozawa, Masahiro; Lee, Ji-Eun; Callen, Elsa; Gutierrez-Martinez, Paula; Chen, Hua-Tang; Wong, Nancy; Finkel, Nadia; Deshpande, Aniruddha; Sharrow, Susan; Rossi, Derrick J; Ito, Keisuke; Ge, Kai; Aplan, Peter D; Armstrong, Scott A; Nussenzweig, André

    2014-10-02

    Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells. Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks, we speculated that DNA damage might also constrain leukaemic self-renewal and malignant haematopoiesis. Here we show that the histone methyl-transferase MLL4, a suppressor of B-cell lymphoma, is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL-AF9 oncogene. Deletion of MLL4 enhances myelopoiesis and myeloid differentiation of leukaemic blasts, which protects mice from death related to acute myeloid leukaemia. MLL4 exerts its function by regulating transcriptional programs associated with the antioxidant response. Addition of reactive oxygen species scavengers or ectopic expression of FOXO3 protects MLL4(-/-) MLL-AF9 cells from DNA damage and inhibits myeloid maturation. Similar to MLL4 deficiency, loss of ATM or BRCA1 sensitizes transformed cells to differentiation, suggesting that myeloid differentiation is promoted by loss of genome integrity. Indeed, we show that restriction-enzyme-induced double-strand breaks are sufficient to induce differentiation of MLL-AF9 blasts, which requires cyclin-dependent kinase inhibitor p21(Cip1) (Cdkn1a) activity. In summary, we have uncovered an unexpected tumour-promoting role of genome guardians in enforcing the oncogene-induced differentiation blockade in acute myeloid leukaemia.

  11. Wedged multilayer Laue lens

    International Nuclear Information System (INIS)

    Conley, Ray; Liu Chian; Qian Jun; Kewish, Cameron M.; Macrander, Albert T.; Yan Hanfei; Maser, Joerg; Kang, Hyon Chol; Stephenson, G. Brian

    2008-01-01

    A multilayer Laue lens (MLL) is an x-ray focusing optic fabricated from a multilayer structure consisting of thousands of layers of two different materials produced by thin-film deposition. The sequence of layer thicknesses is controlled to satisfy the Fresnel zone plate law and the multilayer is sectioned to form the optic. An improved MLL geometry can be created by growing each layer with an in-plane thickness gradient to form a wedge, so that every interface makes the correct angle with the incident beam for symmetric Bragg diffraction. The ultimate hard x-ray focusing performance of a wedged MLL has been predicted to be significantly better than that of a nonwedged MLL, giving subnanometer resolution with high efficiency. Here, we describe a method to deposit the multilayer structure needed for an ideal wedged MLL and report our initial deposition results to produce these structures

  12. Modification of growth medium of mixed-culture species of microalgae isolated from southern java coastal region

    Directory of Open Access Journals (Sweden)

    Sudibyo Hanifrahmawan

    2018-01-01

    Full Text Available Globally, there is growing interest in microalgae as production organisms. Microalgae contain lipids (oil, proteins and carbohydrates (sugars, and, especially marine algae have been used as food and feed for centuries. Recently, production cost reduction related to the supply of growth nutrients is necessary to make it profitable. Therefore, utilization of molasses, a byproduct of sugar production, as the natural carbon, macronutrients, and micronutrients sources can be helpful. The analysis showed that the content of sucrose, glucose, fructose, potassium, zinc, and magnesium was 68.4% w/w, 18.5% w/w, and 13.1% w/w, 5.5% w/w, 3.91 ppm, and 1,370 ppm respectively. This work aimed to determine the effect of molasses addition to the physio-chemical properties of multi-culture species of microalgae isolated from southern Java coastal region in Indonesia grown under mixotrophic culture. The cultivation in this work used medium which was self-formulated by the authors consisting of NaNO3 (5 mL/L, H3BO3 (1 mL/L, EDTA (1 mL/L, N2H2PO4 (5 mL/L, FeSO4 (1 mL/L, MgSO4 (1 mL/L, NaCl (1 mL/L, micronutrients (1 mL/L, vitamin B1 (1 mL/L, and vitamin B12 (1 mL/L in 500 mL of water. The medium will be treated to have molasses concentration of 0.05% v/v, 0.15% v/v, 0.25% v/v, 0.35% v/v, and 0.45% v/v.

  13. [Diagnostic and Treatment Strategies in Morel-Lavallee Lesions in the Spinal Column and Pelvis].

    Science.gov (United States)

    Becker, Christopher A; Kammerlander, Christian; Greiner, Axel; Sommer, Fabian; Linhart, Christoph; Böcker, Wolfgang; Rubenbauer, Bianka; Weidert, Simon

    2018-04-12

    The Morel-Lavallée lesion is one of the concomitant soft tissue lesions of pelvic fractures. Its role in spine fractures and its treatment in combination with osteosynthesis of pelvic or spine fractures have not yet been determined. The aim of this study was to analyse the best diagnostic and treatment options of both spine and pelvic fractures combined with Morel-Lavallée lesions (MLL). An analysis of the literature was performed via PubMed and Medline. This revealed a total of 197 studies and case reports. After analysing the literature, 19 studies/case reports met our inclusion criteria. There are several diagnostic options for MLL, including ultrasound, computed tomography or MRI. In spinal and pelvic lesions, ultrasound is capable of detecting MLL. Some authors tend to perform open debridement of the MLL, whereas others recommend percutanous treatment. Open debridement and vacuum-assisted closure are recommended in late diagnosed MLL, where primary suture of the soft tissue is impossible. Fracture fixation should be performed simultaneously to treatment of the MLL. Broad-spectrum cephalosporins combined with an aminoglycoside or piperacilline/tazobactam should be initiated. Radical debridement and drainage are recommended, especially when MLL is diagnosed late. Repeated ultrasound examinations should be performed of the surrounding soft tissue of the fracture. When MLL is diagnosed within 2 days, percutanous fracture and MLL treatment should be performed. After more than 2 days, both fracture and MLL should be treated with open debridement, open fracture fixation and primary suture if possible. Georg Thieme Verlag KG Stuttgart · New York.

  14. Vikergallup : eesti kirjandus 2001 : [vastused Vikerkaare küsitlusele

    Index Scriptorium Estoniae

    2002-01-01

    Aut.: Vahur Afanasjev, Veiko Belials, Piret Jaaks, Jan Kaus, Janek Kraavi, Priit Kruus, Leo Luks, Ilona Martson, Hedda Maurer, Anneli Mihkelev, Jürgen Rooste, Aarne Ruben, Mihkel Samarüütel, François Serpent, Ivar Sild, Karl Martin Sinijärv, Lauri Sommer, Jaak Urmet, Berk Vaher. 2001. a. parima uudisraamatu tiitlit jagasid Mehis Heinsaare "Härra Pauli kroonikad", Jan Kausi "Maailm ja mõni" ning Ene Mihkelsoni "Ahasveeruse uni"; parimaks esikraamatuks valiti Mehis Heinsaare "Vanameeste näppaja"

  15. ERKÜ valimiste tulemused

    Index Scriptorium Estoniae

    2006-01-01

    8. aprilli koosolekul kinnitas valimiste peakomitee XIX Esinduskogu liikmed: Mati Kõiva, Ylo Anson, Juhan Simonson, Airi Vaga, Gilda M. Karu, Taavo Virkhaus, Marju Rink-Abel, Markus Vaga, Eric Suuberg, Endel Reinpõld, Jaak Juhansoo, Ülle Ederma, Lya Karm, Heino Jõgis, Kersti Linask, Jaak Rakfeldt, Erik Puskar, Jüri Linask, Viiu Vanderer, Andres Kurrik, Mati Valdek Laan, Ilmar Vanderer, Henno Uus, Jüri Tults, Urmas Wompa, Astrid Jaanson, Jüri Virkus, Lilian G. G. Bein, Tiina Harris, Tõnu Vanderer

  16. Vormistatud ruumid 2010 / Kai Lobjakas

    Index Scriptorium Estoniae

    Lobjakas, Kai, 1975-

    2011-01-01

    Eesti Sisearhitektide Liidu 2010. a. preemia saanud töödest. Söögikoha interjööri preemia: kohvik Supelsaksad Pärnus (Ruth, Jaak ja Anna Huimerind), ühiskondliku interjööri preemia: ADM Interactive'i büroo Tallinnas (Tomomi Hayashi, Ahti Grünberg, Kerli Valk), ajaloolise interjööri preemia: Kihnu muuseum (Malle Jürgenson, Tea Tammelaan, Krista Lepland, Jaak Huimerind, Indrek Laos), näituse- ja installatsiooni kujunduse preemia: rändnäitus "Eesti kirjanik karikatuuris" (Janno Siimar, Kaarel Vahtramäe, Mart Lankots, Liina Jakobson), tudengipreemia - Aet Tera

  17. Nava tiigi ääres seiklevad Hunt ja Rebane / Liisi Seil ; kommenteerinud Pille Põllumäe

    Index Scriptorium Estoniae

    Seil, Liisi, 1971-

    2009-01-01

    17.-19. juulini Lilli külas Nava talus toimuvast 4. Nava lava festivalist. 19. 07 mängib Karksi valla kultuurikeskuse noorteteater "O" lasteetendust "Hundi ja Rebase lend lõunanabale", mille on Nava talu peremehe Jaak Kõdari raamatu "Kriimureinulised lood. 3, Argonaudid" põhjal kirjutanud ja lavastanud Silvia Soro. Kostüümid tegi Thea Ilusmets. 17., 18. ja 19. 07 mängitakse Jaak Kõdari mulgikeelset külanäitemängu "Kõik läheb mööda, kõik tuleb jälle. 1912-1918", lavastaja Silvia Soro

  18. Põlva Agro omanikud teenisid 200 miljonit / Liis Kängsepp

    Index Scriptorium Estoniae

    Kängsepp, Liis, 1981-

    2008-01-01

    2007. aastal toimus OÜ Põlva Agro enamusosaluse kokkuost Jaak Hinrikuse poolt, nüüdseks on ettevõte müüdud Leedu Agrowill Groupile. Vt. samas: Agrowill: suuri muutusi plaanis ei ole; Jaak Hinrikus: ostsime kokku, et säilitada kontrolli. Lisa: Agrowill Group; Põlva Agro. Diagrammid: Põlva Agro kasvatab kiirelt kasumlikkust; Agrowilli aktsia on kallinenud pärast börsiletulekut täpselt poole võrra. Tabel: Tähtsamad majandusnäitajad

  19. Immunophenotypic investigation of infant acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    A. M. Popov

    2012-01-01

    Full Text Available Aim of the study – immunophenotype description of infant acute lymphoblastic leukemia (ALL. 64 patients (29 boys and 35 girls with acute leukemia (AL aged from 0 to 11 months were included in the current study. ALL was found less frequently in infants than in older children (67.19 % and 87.69 %, respectively. BI-ALL was the most common immunological ALL type (60.46 % in infant ALL, while BII-ALL was notably less frequent compared with other age groups (30.23 %. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD10, CD20, CD45, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD10- and CD20-negativity, high CD45, CD15, CD65 and NG2 expression were immunophenotypic signatures of MLL-rearranged infant ALL, although NG2 had the highest diagnostic efficacy. High CD34 and CD65 expression was frequently associated with presence of MLL-AF4 fusion gene. Thus infants’ B-cell precursor ALL immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ ALL allows predicting presence of MLL rearrangements and NG2 is the most applicable single marker.

  20. Immunophenotypic investigation of infant acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    A. M. Popov

    2014-07-01

    Full Text Available Aim of the study – immunophenotype description of infant acute lymphoblastic leukemia (ALL. 64 patients (29 boys and 35 girls with acute leukemia (AL aged from 0 to 11 months were included in the current study. ALL was found less frequently in infants than in older children (67.19 % and 87.69 %, respectively. BI-ALL was the most common immunological ALL type (60.46 % in infant ALL, while BII-ALL was notably less frequent compared with other age groups (30.23 %. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD10, CD20, CD45, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD10- and CD20-negativity, high CD45, CD15, CD65 and NG2 expression were immunophenotypic signatures of MLL-rearranged infant ALL, although NG2 had the highest diagnostic efficacy. High CD34 and CD65 expression was frequently associated with presence of MLL-AF4 fusion gene. Thus infants’ B-cell precursor ALL immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ ALL allows predicting presence of MLL rearrangements and NG2 is the most applicable single marker.

  1. EFEKTIVITAS PEMBERIAN URIN KELINCI UNTUK MENGURANGI DOSIS PUPUK ANORGANIK PADA BUDIDAYA PUTREN JAGUNG MANIS

    Directory of Open Access Journals (Sweden)

    Chintia Fitriasari

    2018-01-01

    Increased production of sweet corn corn (Zea mays L. var. Indurata should be balanced with sufficient nutrients during its growth. The study was conducted from January to March 2017 at the Experimental Garden of the Faculty of Agriculture, University of Muhammadiyah Jakarta. The experimental design used was the Randomized Complete Block Design (RCBD with six treatments consisting of P0 (100% Inorganic fertilizer (Control; P1 (Rabbit urine 20 ml.l-1 of water + 50% inorganic fertilizer; P2 (Rabbit urine 25 ml.l-1of water + 50% inorganic fertilizer; P4 (Rabit urine 35 ml.l-1of water + 50% inorganic fertilizer; and P5 (Rabbit urine 40 ml.l-1of water + 50% inorganic fertilizer. Each treatment was repeated 4 times so that there were 24 experimental units, each units consists of 3 plants. The result, utilization of rabbit urine 25 ml.l-1of water + 50% inorganic fertilizer gives the highest value of plant height, leaf and widest leaf area. Utilization of rabbit urine 40 ml.l-1 of water + 50% inorganic fertilizer gives the fastest of flowering age of males and females. Utilization of rabbit urine 30 ml.l-1 of water + 50% inorganic fertilizer gives haighest value of total, length, diameter and the weight of cobs.

  2. Eesti tippteadlaste panus maailma : päästvad bakterid ja täiustatud elektroonika / koost. Jüri Allik

    Index Scriptorium Estoniae

    2007-01-01

    Jüri Allik lappas maailma suurimat teaduskirjanduse andmebaasi ISI Web of Science. Enimviidatud Eesti teadlased on: Jaan Aarik, Jaak Jürimäe, Mati Karelson, Marco Kirm, Eero Vasar, Mihkel Zilmer, Ülo Niinemets, Kaupo Kukli, Enn Lust

  3. Eesti skulptor Argentiinas

    Index Scriptorium Estoniae

    1998-01-01

    18.-25. juulini Resistencias toimunud rahvusvahelisel keskkonnaskulptuuride biennaalil osalenud Jaak Soans sai minimalistliku lehtrauast töö 'Ühendus' eest Nuovo Banco del Chaco eripreemia. I preemia - Raټl Pajáro Gomez, II - Thomas Kühnapfel, III - Eric Verhelst

  4. India äri eripära / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2007-01-01

    India antiikmööblit maale toova ID House juht Jaak Morna kirjeldab isikliku kogemuse kaudu India äritavasid ning töökorraldust. Lisa: India; Indiast saab triljonimajandus; Eesti-India majandussuhted; Kinnisvarahinnad teevad meile silmad ette

  5. Siin oli Tammsaare töökabinet / Ilmar Palli

    Index Scriptorium Estoniae

    Palli, Ilmar, 1948-

    2009-01-01

    Külas Koitjärvel Kõvasoo talu taastanud Jaak Veisserikil. Vajadusest jäädvustada Koitjärvel A. H. Tammsaare mälestust: Tammsaare elas a-tel 1911-1919 (vaheaegadega) vend Jüri Hanseni Oru metsavahitalus

  6. Otepää piiskoplinnuse hävimisdaatumist / Ain Mäesalu

    Index Scriptorium Estoniae

    Mäesalu, Ain, 1955-

    2010-01-01

    Ülevaade, miks autor hakkas 1980. aastate keskel toetama hüpoteesi Otepää keskaegse linnuse hävimisest 1396. aastal. Samas on kriitiliselt vaetud sama ajakirja numbris mõningaid Jaak Mälli seisukohti

  7. Algab sari "Kontserdid Kunstihoones". Bachi "Jõuluoratoorium" Jaani kirikutes

    Index Scriptorium Estoniae

    2008-01-01

    Soprani Kersti-Ala Murri ja akordionisti Jaak Lutsoja kontserdist Eesti Interpreetide Liidu korraldatava kontserdisarja "Kontserdid Kunstihoones" raames 21. dets. Tallinna Kunstihoone suures saalis. J. S. Bachi "Jõuluoratooriumi" ettekandest 28. dets. Tartu Jaani kirikus ja 29. dets. Tallinna Jaani kirikus (esinevad kammerkoor Voices Musicales solistidega ja Corelli Barokkorkester, dirigent Risto Joost)

  8. Tartu Ülikooli 86. aastapäeva tähistamine Torontos : "Põhjamaine järjekindlus ja hiinlase kannatus" / Tiina Ann Kirss ; fotod: V. Sarapuu

    Index Scriptorium Estoniae

    Kirss, Tiina, 1957-

    2005-01-01

    aktusega Tartu Collegéis 27. novembril 2005. Ülikooli rektor Jaak Aaviksoo analüüsis oma kõnes TÜ arenguvõimalusi ja päevamuresid, Tiina Kirss esitas sissevaate ülikooli ajalukku, muusikalises osas esinesid Kaili ja Riho Maimets

  9. Hea vaistuga miljardiliigutaja Steve Jurvetson / Lauri Levo

    Index Scriptorium Estoniae

    Levo, Lauri

    2005-01-01

    Ilmunud ka: Life in Estonia 2005/06, Winter, lk. 24-27. Riskiinvesteerimisfirma Draper, Fisher, Jurvetson (DFJ) üks omanikke Steve Jurvetson tutvustab oma tüüpilist tööpäeva, haridusteed ja hobisid. Kommenteerib AS-i IT Grupp asutaja ja tuumikinvestor Jaak Ennuste

  10. Ühinemine on kohapealse arengu seisukohalt strateegiline otsus / interv. Helle Ruusing

    Index Scriptorium Estoniae

    2008-01-01

    Riigikogu liikmed Jaak Aab ja Rein Aidma, regionaalminister Siim-Valmar Kiisler, Linnade Liidu tegevdirektor Jüri Võigemast, Maaomavalitsuste Liidu tegevdirektor Ott Kasuri ja Tallinna Ülikooli avaliku poliitika professor Georg Sootla arutavad vestlusringis kohalike omavalitsuse õigusi ja kohustusi, liitumise olulisust ja haldusreformi arenguperspektiive

  11. Varjamine: samba salalepingud tõid tšehhidele lisamiljoneid / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2010-01-01

    Kaitseminister Jaak Aaviksoo ja Tšehhi klaasifirma sõlmisid 2009. a. lepingu muutmise lepingu koos paljude uute lisadega. Lepingu lisas nõudis kaitseminister kollase tooniga risti ringiosa paneelide väljavahetamist, kuid tookord teatas ministeerium, et paneelid vastavad esialgsel hinnangul kokkulepitule. Ministeeriumi avalike suhete osakonna juhataja Martin Jaško ja vandeadvokaat Martin Tamme selgitusi

  12. Dzhässimaal, avalik loomevabadus / Tui Hirv

    Index Scriptorium Estoniae

    Hirv, Tui, 1984-

    2008-01-01

    20. aprillil Tallinna Kunstihoones toimunud üritusest Dzhässimaal, kus improviseeris 20.04.2008 Estonian Guitar Octet koosseisus Jaak Sooäär, Paul Daniel, Robert Jürjendal, Tõnis Leemets, Virgo Sillamaa, Mart Soo, Kalle Tikas ja Tarvo Kaspar Toome. Samal ajal maalisid pilte noored kunstnikud Tallinna kunstikoolist, Sally stuudiost ja Pelgulinna kunstigümnaasiumist

  13. Ilves lennutati käepigistuseks hiiglaslikule sõjalaevale / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2007-01-01

    President Toomas Hendrik Ilves, Riigikogu esimees Ene Ergma, kaitseväe juht Ants Laaneots, kaitseminister Jaak Aaviksoo ja mitu parlamendiliiget külastasid Vahemeres seilavat maailma esimest tuumajõu abil liikuvat lennukikandjat USS Enterprise. Vabariigi Presidendi visiit Ameerika Ühendriikide sõjalaevastiku lennukikandjale USS Enterprise

  14. Eesti funktsionalismi näitus Jyväskyläs / Karin Hallas-Murula

    Index Scriptorium Estoniae

    Hallas-Murula, Karin, 1957-

    2002-01-01

    6. VIII-15. IX Alvar Aalto muuseumis Eesti Arhitekuurimuuseumi näitus "Funktsionalism Eestis". Eksponeeritakse 1930. aastate originaalprojekte, digitaliseeritud ajaloolisi fotosid ning makette. Näituse ja kataloogi on koostanud Karin Hallas-Murula, näituse kujundanud Peeter Mauer, kataloogi kujundanud Jaanus Tamme ja Jaak Peep (Tank)

  15. Eesti graafika etteaste Londonis / Urmas Viik

    Index Scriptorium Estoniae

    Viik, Urmas, 1961-

    2006-01-01

    Balti graafikanäitusest "Power and man" Londonis Novas galeriis. Eestit esindavad oma loominguga Peeter Allik, Urmas Viik, Kadri Alesmaa, Jaak Visnap, Inga Heamägi, Aili Vahtrapuu. Inglise skulptori Marc Quinni skulptuur rasedast Alison Lapperist Trafalgari väljakul

  16. ETV ekraanigraafika on Euroopa parimate seas / René Vilbre

    Index Scriptorium Estoniae

    Vilbre, René, 1970-

    2011-01-01

    Euroopa avalik-õiguslikle telejaamade konkurentsis valiti ETV ekraanigraafika viie parima hulka. Finaali pääses ETV kahes kategoorias - "Best design package" ja "Best use of audio". Intervjuu vaheklippide autori René Vilbrega. Võttemeeskonda kuulusid veel toimetaja Anu Välba, operaatorid Kristjan-Jaak Nuudi ja Ergo Treier

  17. 101 riigikogulast said valijalt ehmatava liputervituse / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 4. sept. lk. 4. Valija Tiina Talts saatis presidendivalimiste esimese päeva hommikul parlamendiliikmetele kirja, mille juurde oli ümber disainitud Eesti lipp. Vastused saatsid neli saadikut, nende hulgas Mait Klaassen, Jaak Allik, Janno Reiljan

  18. "Su mõte on see, mida elad" : vanadus / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2005-01-01

    Reet Varblase kuraatoriprojektist "Homo grandis natu" Tallinna Kunstihoones kuni 15. V. Tallinna Kunstikooli õpilaste (õpetaja Katrin Tukmann), Katarzyna Kozyra, Eveli Variku, Marge Monko, Piia Ruberi & Doris Kareva ja Mare Mikofi töödest, Tallinna Ülikooli audiovisuaalkunsti osakonnas tehtud filmidest (Elen Lotman, Jaak Kilmi, Kalev Hiller)

  19. "Keisri hull" pürib taas filmiks

    Index Scriptorium Estoniae

    2008-01-01

    Eesti Filmi Sihtasutus otsustas anda arendustoetust mängufilmidele "Keisri hull" (režissöör Peeter Simm, arendaja Lege Artis Film), "Rahad ette" (režissöör Jaak Kilmi, arendaja Eetriüksus), "Öölendurid" (režissöör Peeter Urbla, arendaja Exitfilm)

  20. "Keisri hull" on viimast korda laval

    Index Scriptorium Estoniae

    2010-01-01

    Neli hooaega Ugala repertuaaris olnud Jaan Krossi romaani põhjal lavastatud draama "Keisri hull" etendub viimast korda 10. veebruaril. Viimane etendus on pühendatud Jaan Krossi 90. sünniaastapäevale, mis on 19. veebruaril. Lavastajad Peeter Tammearu ja Jaak Allik. Peaosas Peeter Tammearu

  1. LEADER Eestis - mis toimub, mis toimumas? / Ave Bremse

    Index Scriptorium Estoniae

    Bremse, Ave

    2008-01-01

    LEADER-programmi rakendumise edukusest Eestis. Vt. samas: 1. Kuidas teie kohalikul tegevusgrupil läheb? 2. Mida uut on toonud LEADER teie piirkonda? Küsimustele vastavad: Aili Ilves, Hardi Murula, Merle Adams, Sille Tars, Jaak Vitsur, Mercedes Merimaa ja Piia Kärssin. Lisa: Statistikat ja infot kohalike tegevusgruppide kohta

  2. Vanemuise sünd. Lisandusi eesti pseudomütoloogia ajaloole / Aivar Põldvee

    Index Scriptorium Estoniae

    Põldvee, Aivar, 1962-

    2013-01-01

    Seni vähe tähelepanu leidnud tahkudest Vanemuise sünniloos. Kirstian Jaak Petersoni ja Friedrich Robert Faehlmanni Vanemuise käsitlustest. Eelloona vajalikest Thomas Hiärne ja Garlieb Helwig Merkeli muinasloo käsitlustest. Eestlaste ja soomlaste sugulusest ja ühismütoloogiast

  3. Muusikalised jutustused

    Index Scriptorium Estoniae

    2008-01-01

    Üritustest kontsertsarja Soul Spectrum raames Kumus: 14. märstsil Ursula Rucker (soojendusesinejad Riho Sibul, Jaak Sooäär ja Raul Saaremets), 15. märtsil folk-jazzlaulja Terry Callier (soojendusesinejad Tõnis Mägi ja Chalice)

  4. Millele pöörate eluaseme ostmisel ja üürimisel tähelepanu?

    Index Scriptorium Estoniae

    2005-01-01

    Küsimusele vastavad Brüsselis tööd otsiv Kadri Kuusk, Sampo Panga koolitusosakonna juhataja Külli Meier, finantsinspektsiooni osakonnajuhataja Andre Nõmm, Riigikogu liige Meelis Atonen, Palivere lastekodu juhataja Külle Saar, Helsingis töötav arst Jaak Kiviloog, Narva kooliõpetaja Julia Ivanova, maksu- ja tolliameti peaspetsialist Tiiu Kilk

  5. USA kaitseminister Robert Gates süüdistas liitlasvägesid oskamatuses / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2008-01-01

    USA kaitseminister Robert Gates väitis ajalehes The Los Angeles Times avaldatud intervjuus, et Lõuna-Afganistani olukord on halvenenud seal võitlevate USA liitlasvägede puuduliku väljaõppe tõttu. Liitlasriikide reageeringuid. Arvamust avaldavad Jaak Aaviksoo, Kaarel Kaas

  6. Saaremaal valmib terasmehe häll / Aivo Vahemets

    Index Scriptorium Estoniae

    Vahemets, Aivo

    2005-01-01

    Eesti ettevõttes Michelle OÜ kaubamärgi all Inox Disain Lab toodetakse roostevabast terasest konstruktsiooniga voodeid. Ettevõtet juhib Jaak Kangro. Voodinäidised on Tallinnas Pärnu mnt. 22 ateljees või interneti koduleheküljel www.inox.ee

  7. Jutt suusatamise surmast on liialdus / Toomas Huik, Deivil Tserp

    Index Scriptorium Estoniae

    Huik, Toomas

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 5. märts, lk. 12. Kristina Shmigun tuli 30 km klassikasõidus kuuendaks, Jaak Mae 50 km klassikasõidus kaheksandaks ja Kaspar Kokk üheteistkümnendaks. Kommenteerib Eesti suusakoondise peatreener Mati Alaver

  8. Siidii / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2003-01-01

    Heliplaatidest: Millenia Nova "Narcotic Wide Screen Vista", Trygve Seim "Different Rivers", Eesti Keeled ja Jaak Johanson, Riho Sibul "Sabaga Täht", Peeter Vähi, Fedor Vetkalov, Dmitri Tkachenko "Best Regards From Tallinn And Moscow", Brainstorm "A Day Before Tomorrow", Allegri, Pärt, Tormis "Light"

  9. Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

    Index Scriptorium Estoniae

    Schwidtal, Michael

    2001-01-01

    3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

  10. Armastus ja anarhia / J[aan] R[uus

    Index Scriptorium Estoniae

    J. R.

    1993-01-01

    Helsingi filmifestivali "Armastus ja anarhia" mängufilmid "Nekromantik I" (1987) ja "Nekromantik II" (1991), režissöör Jörg Buttgereit ja "Trellimõrtsukas" (1979), režissöör Abel Ferrara, Tallinna kinos "Eha". Arvustavad Rainer Sarnet, Jaak Kilmi, Marko Raat ja J. R. (Jaan Ruus)

  11. Ilmus esimene mahukam eestikeelne teatriajaloo ülevaade / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    25. jaan. esitleti Eesti Teatriliidus "Oxfordi illustreeritud teatriajaloo" eestikeelset versiooni. Tõlkeraamatu aluseks on 1995. aastal kirjastuses Oxford University Press ilmunud samanimeline raamat, mille koostajaks on John Russell Brown. Teose on tõlkinud Anne Lange, Ilona Kolberg, Piret Kruuspere, Kristjan Jaak Kangur

  12. Kalevi kommivabrik läks Luksemburgi investeerimisfondile / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    Kalevi ja Tere omandanud Luksemburgis registreeritud fondi Alta Capital Partners S.C.A. osanikud on 80% ulatuses Indrek Rahumaa, Andres Rätsepp, Jaak Raid ja Marius Binkevicius, 20% osakutest kuulub Briti varahaldusfirmale Bonfield Asset Management. Fondi hakkab haldama Läti firma Alta Capital Partners SIA. Skeemid: Mis Oliver Kruudale alles jäi? Mida Indrek Rahumaa ostis

  13. Ökokunst Viljandi "Kiriküüdil" / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2002-01-01

    Lõppes seitsmes ökoteemaline "Kiriküüt". Ürituse organiseerijate eesotsas on pikemalt olnud Tiiu Männiste ja Mari Sobolev. Jakobsoni kuju juures kandsid kirikuõpetaja Mart Salumäe ja "Ugala" direktor Jaak Allik ette rühmituse VSN performance'i "Mulgi näide". Ökoloogiast

  14. "Riik malelaual" = "Country on a Chessboard" / Tarmo Piirmets ; kommenteerinud Laura Kipper

    Index Scriptorium Estoniae

    Piirmets, Tarmo, 1974-

    2015-01-01

    Eesti Ajaloomuuseumi näitus "Riik malelaual. Saksa okupatsioon Eestis 1941-1944" Maarjamäe suvemõisa tallihoones, kuraator Olev Liivik. 19. sajandist pärit tallihoone renoveerimisest. Autor Tarmo Piirmets (Pink); arhitektid Jaak Huimerind, AB Studio Paralleel

  15. Uue kunsti tegijad pakuvad head maali / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2006-01-01

    Pärnuga seotud või Pärnust pärit kunstnike uuem looming näitusel "Looja, loo lugu, loo lugu, looja, loo..." Pärnu Uue Kunsti Muuseumis. Osalevad Toomas Kuusing, Siram, Bruno Sõmeri, Anonymous Boh, Mark Soosaar, Jaak Visnap, Mila Balti, Kadri Alesmaa, Bille Neeve. Kuraator Andrus Joonas

  16. Kihnu muuseum = Kihnu museum

    Index Scriptorium Estoniae

    2011-01-01

    Eesti Sisearhitektide Liidu 2010. a. ajaloolise interjööri preemia pälvinud Kihnu muuseumist. Sisearhitektid: Malle Jürgenson, Tea Tammelaan, Krista Lepland (Laika, Belka & Strelka OÜ), loetletud nende ühiselt tehtud töid. Arhitektid: Jaak Huimerind, Indrek Laos

  17. Programma EQUAL : ravnõe vozmozhnosti na rabote / Ksenia Repson

    Index Scriptorium Estoniae

    Repson, Ksenia

    2006-01-01

    Tallinnas toimunud 23 Euroopa Liidu liikmesriigi EQUAL programmile pühendatud foorumist, mille eesmärgiks on vähendada diskrimineerimist töökohtadel. Eestis EQUAL programmi raames töötavatest projektidest. Foorumist võttis osa ka sotsiaalminister Jaak Aab. Lisa

  18. 7. X avati Viljandis Kondase keskuses litograafianäitus

    Index Scriptorium Estoniae

    2003-01-01

    Eesti Litograafiakeskuse korraldatud näitusel tutvustatakse litograafiatehnikat ja selle ajaloolist arengut. Väljas on Pärnus 5.-25. IX Eesti I litograafiasümpoosioni raames toimunud näitustel "Old Stars" ja "Young Generation" eksponeeritud eesti graafikute litotehnikas teosed ning näituse koostajate Jaak Visnapi ja Kadri Alesmaa looming

  19. Arhetüüpse ja shiki kohtumine : ärihoone "Ferrum" Saaremaal Kuressaares = Encounter of Archetypal and Chic : Ferrum Centre in Saaremaa in Kuressaare / Ingrid Lillemägi

    Index Scriptorium Estoniae

    Lillemägi, Ingrid

    2003-01-01

    Projekteerija: Alver Trummal Arhitektid. Autorid Andres Alvar, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets. Konstruktor Jaak Juha (Tööstusprojekt). Projekt 2001, valmis 2002. Stiilse ruumi vastuolu seda asustavate poodide kirju kribu-krabu ja juhuslike reklaamplakatitega. I ja II korruse plaan, 5 välis- ja 2 sisevaadet

  20. Eestil odava tööjõu eelis kadunud / Liis Kängsepp

    Index Scriptorium Estoniae

    Kängsepp, Liis, 1981-

    2005-01-01

    Database Central Europe'i tehtud tööjõu maksumuse uuringu järgi on tööjõukulu Eestis tunduvalt suurem kui Lätis, Leedus ning mitmes Ida-Euroopa riigis. Diagrammid. Kommenteerivad: Peep Siimon, Taavi Veskimägi, Jaak Leimann ja Ilmar Petersen

  1. Tagurpidi pööratud poliitika / Ivar Tallo

    Index Scriptorium Estoniae

    Tallo, Ivar, 1964-

    2009-01-01

    Autor näeb vastuolu seoses vaidlusega kaitseväelaste õiguse üle määrata enda hukkumishüvitise saaja: konservatiivse IRL-i minister Jaak Aaviksoo kaitseb sõdurite valikuvabadust ning liberaalist Reformierakonna minister Jürgen Ligi tahaks sõdurite eest otsustada

  2. Tõrvapott ja meetilgad / Ivar Tallo

    Index Scriptorium Estoniae

    Tallo, Ivar, 1964-

    2002-01-01

    Ilmunud ka: Põhjarannik ; Severnoje Poberezhje 2. oktoober lk. 2. Riigikogu liikmete palgast ja ametihüvedest. Autor: Rahvaerakond Mõõdukad. Vt. samas küsitlus Kuidas suhtute Riigikogu liikmete peaaegu kontrollimatutesse hüvitistesse? Vastavad: Eri Klas, Jaak Mae, Kuno Pajula, Mati Unt

  3. Эстонский фильм взял приз на кинофестивале

    Index Scriptorium Estoniae

    2009-01-01

    Itaalias Trieste filmifestivalil tunnistati parimaks dokumentaalfilmiks ja omistati Alpe Adria Cinema preemia filmile "Revolutsioon, mida ei tulnud" (režissöör Aljona Polunina, produtsendid Ilkka Matila ja Jaak Kilmi; tootjad Kuukulgur Film ja Matila Röhr Productions Soomest, 2008)

  4. Raamat Läänemere vägilastest - jäälõhkujatest / Taavi Kelder

    Index Scriptorium Estoniae

    Kelder, Taavi

    2006-01-01

    rets. rmt.: "Suur Tõll" ja teised Eesti jäämurdjad/Vladimir Kopelman, Jaak Sammet, Peedu Sammalsoo...[jt.]; koostaja Mati Õun. Tallinn: Sentinel, 2005. 98 lk. : ill. Tiitellehel ka autorid: Mati Õun, Olaf Vaarmaa, Heino Arumäe, Roman Matkiewitcz

  5. USA moos määrib Eesti naabritest mõjukamaks / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2007-01-01

    Sel sügisel on toimunud mitu Eesti ja USA poliitikute kohtumist. Peaminister Andrus Ansipi ja kaitseminister Jaak Aaviksoo USA-visiitide korraldamisega kursis olevad ametnikud ei nõustu, et kohtumiste taga oleks olnud USA lobitöö Iraagi missiooni pikendamiseks

  6. Punk film kodanikuühiskonnast / Artur Talvik, Peeter Vihma, Jaan Tootsen ; intervjueerinud Andrei Liimets

    Index Scriptorium Estoniae

    Talvik, Artur, 1964-

    2013-01-01

    Tallinna Uue Maailma kogukonnast rääkivast režissöör Jaan Tootseni ja produtsent Jaak Kilmi dokumentaalfilmist "Uus Maailm". Arutlus teemal, milline on kohaliku kogukonna ja milline riiklike ning kohalike institutsioonide roll paikkonna elu suunamisel ja koordineerimisel, nende omavaheline mõju

  7. Viljandi sõudeelling = Viljandi Rowing Slipway / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Viljandis Ranna pst. 13 asuva sõudeellingu arhitektuursest lahendusest. Arhitektid Lauri Saar, Toomas Paaver, Indrek Järve (Paik Arhitektid OÜ), kaasautorid Jaak-Adam Looveer, Tõnu Laanemäe. Žürii liige Kalle Komissarov žürii hinnangust kultuurkapitali aastapreemiale esitatud ehitisele

  8. Marilyn Monroe eluloost keisri hullu kannatusteni / Gert Kiiler

    Index Scriptorium Estoniae

    Kiiler, Gert

    2006-01-01

    Ugala uut hooaega tutvustavad lavastajad. Jaak Allik ja Peeter Tammearu lavastavad Jaan Krossi romaani "Keisri hull" järgi samanimelise näidendi, Priit Võigemast Igor Bauersma "norway.today", Kristi Teemusk omakirjutatu järgi lastelavastuse "Kes päästab koletise?" ja Kalju Komissarov Eppu Nuotio, Tiina Brännare muusikali "Marilyn"

  9. Männik ohverdas Aaviksoo

    Index Scriptorium Estoniae

    2003-01-01

    Eesti Telekomi nõukogu otsusest vabastada ametist EMT juhatuse esimees Peep Aaviksoo, uuest kandidaadist Valdo Kalmust ning EMT ja Elioni võimalikust ühinemisest. Diagramm: EMT turuosa libiseb Tele2-le. Vt. samas: EMT lahkuva juhi Peep Aaviksoo avalik kiri. Kommenteerivad Sami Seppänen, Üllar Jaaksoo, Monika Salu, Jaak Aaviksoo, Toomas Tamsar

  10. Kuidas raamida merd? / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2005-01-01

    Korter Tallinnas Pirita teel. Sisekujundus: Ilona Põldme, OÜ Põldme. Ehitaja: OÜ Onix Invest. Olulise osa mööblist kavandas I. Põldme, valmistas OÜ Timbermeister. Elutoas kompositsioon Epp Maria Kokamäe maalist ja Jaak Arro puulõikest. Ilona Põldmest, tema tähtsamad tööd. Ill.: plaan, 19 värv. vaadet

  11. Et ainult inimene mõtleb? Ajab rotigi naerma! / Mati Soomre

    Index Scriptorium Estoniae

    Soomre, Mati, 1944-2015

    2008-01-01

    USA Bowling Green State'i ülikooli emeriitprofessor, Tartu Ülikooli audoktor professor Jaak Panksepp väidab, et rotid naeravad ning USA Georgia Ülikooli teadlased Allison Foote ja Jonathon Crystal leidsid, et ka rotil on metakognitsioon - võime oma mõtlemist mõelda. Vt. ka lk. 35: Rott & meie

  12. Aleksander Simon / J. K.

    Index Scriptorium Estoniae

    Kukk, Jaak, 1904-2001

    1992-01-01

    Aleksander Simon õppis veterinaariat, kuid ei lõpetanud, korporatsiooni astus kohe selle asutamisel ja Jaak Kukk oli tema akadeemiline kasuisa, kellele anti teada, et 1944. a Saksamaale rännanud A. Simon üritas 1946 salaja Rootsi põgeneda

  13. Ähvardus : olümpiamängude teleülekanne jääb ära / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2005-01-01

    Riigikogu liige Jaak Allik peab vajalikuks leida ETV-le lisamiljoneid olümpiamängude ja jalgpalli MM-i teleülekanneteks. Riigikogu liikmed Olav Aarna ja Katrin Saks kritiseerisid valitsust, et rahvusringhäälingu arengukava suhtes pole võetud seisukohta. Kultuuriminister Raivo Palmaru arvamusi. Lisa: Ringhäälingureform tulekul

  14. Remo Holsmer: mees Kalevi pingi taga / Remo Holsmer ; interv. Peep Lillemägi

    Index Scriptorium Estoniae

    Holsmer, Remo, 1980-

    2009-01-01

    Reformierakonna Tallinna piirkonnajuht Remo Holsmer vastab küsimustele, mis puudutavad tema tööd Kalevi korvpalliklubi managerina, korvpalli taset Eestis, Kalevisse välismängijate leidmist, Tallinna Kalev-Tartu Rock vastasseisu ning suhteid Jaak Salumetsaga

  15. TÜ nõukogu nimetas neli uut professorit ja emeriitdotsendi

    Index Scriptorium Estoniae

    2012-01-01

    TÜ nõukogu valis 2011.a. detsembri istugil professoriteks Helle Karro (sünnitusabi ja günekoloogia alal), Jaak Vilo (bioinformaatika alal), Varmo Vene (programmeerimiskeelte semantika alal), Marlon Dumas (tarkvaratehnika alal) ja emeriitdotsendiks majandusõppejõud Kersti Meiesaar

  16. Ants Orasest ja Anne Lange monograafiast / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2005-01-01

    Arvustus: Oras, Ants. Luulekool. I, Apoloogia / koostajad Hando Runnel ja Jaak Rähesoo. Tartu : Ilmamaa, 2003 ; Oras, Ants. Luulekool II, Meistriklass. Tartu : Ilmamaa, 2004 ; Lange, Anne. Ants Oras : [kirjandusteadlane, -kriitik ja tõlkija (1900-1982)]. Tartu : Ilmamaa, 2004

  17. Eesti rahvusliku tahte triumf? / Tarmo Jüristo

    Index Scriptorium Estoniae

    Jüristo, Tarmo

    2010-01-01

    Autor analüüsib kaitseminister Jaak Aaviksoo Tartu rahu aastapäevale pühendatud kõnet, milles kaitseminister viitas tahtmatult 1934. aasta propagandafilmile "Tahte triumf" ("Triumph des Willens"), mis kujutas Adolf Hitleri saabumist natsionaalsotsialistliku partei Nürnbergi konverentsile

  18. Kahtlus närtsitab Merkot / Toomas Annus ; interv. Ralf-Martin Soe

    Index Scriptorium Estoniae

    Annus, Toomas, 1960-

    2008-01-01

    Altkäemaksukahtlustus viib Merkolt lepinguid. Küsimustele vastab Merko suuromanik Toomas Annus. Vt. samas: Haavatud Merko kutsub aktsionärid appi; Jaak Saarniit: riigihangete puhul Merkot nurka ei visata; Milles Merko Ehitust süüdistatakse?; Merkot ootab aastatepikkune vaidlus; Diagramm: Aktsia hind

  19. Piimatööstused kukkusid kahjumisse / Aare Annus ; interv. Silja Lättemäe

    Index Scriptorium Estoniae

    Annus, Aare

    2005-01-01

    Tallinna Piimatööstuse AS-i nõukogu esimees Aare Annus Eesti piimatööstuste raskest olukorrast seoses toorpiima kõrge kokkuostuhinnaga. Vt. ka: Kas saite piimahinnast kõva kasumit? Küsimusele vastavad Järvamaa talunik Arvo Kuutok ja Põlva Agro OÜ nõukogu esimees Jaak Hinrikus

  20. Külanäitemäng üllatas tenori ja kooriga / Liisi Seil

    Index Scriptorium Estoniae

    Seil, Liisi, 1971-

    2009-01-01

    17.-19. juulini toimus Lilli külas 4. Nava lava festival. Loeti luulet ja mängiti Jaak Kõdari kirjutatud mulgikeelset näitemängu "Kõik läheb mööda" ning lasteetendust "Hundi ja Rebase lend lõunanabale". Mõlemad lavastas Silvia Soro

  1. Piiriäärne lava valmistub taas esietenduseks / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2008-01-01

    Lõuna-Eestis Lilli külas algaval Nava lava festivalil tuuakse publiku ette Nava talu peremehe Jaak Kõdari näidend "Jukra", lavastaja Silvia Soro. Üht kandvat rolli mängib näitleja Lembit Eelmäe

  2. "Marilyn" korjas õunad endale / Tiina Sarv

    Index Scriptorium Estoniae

    Sarv, Tiina, 1949-

    2007-01-01

    Ugala tiigi ääres jagati 21. juunil Kuldõuna nime kandvaid publikupreemiaid. Kuldõuna laureaadid on "Marilyni" lavastaja Kalju Komissarov, kujundaja Jaak Vaus, nimosatäitja Hilje Murel ning lavastuses "Kolm klaasikest kirsiviina" silma paistnud näitleja Aarne Soro

  3. Komistusi ajaloo järskudel radadel / Vello Helk

    Index Scriptorium Estoniae

    Helk, Vello, 1923-2014

    2007-01-01

    kommentaare Olaf Kuuli, Magnus Ilmjärve ja Jaak Valge ajaloo-uurimustele, Ronald Reigani kõnest 12. juunil Brandenburgi värava juures, Venemaa ja Läänemaailma demokraatia erinevusest, vajadusest ajalooallikaid õigesti tõlgendada

  4. Modernismi tõlgendamine jätkub / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2007-01-01

    Rahvusvaheline kunstiajalookonverents "Erinevad modernismid, erinevad avangardid. Kesk- ja Ida-Euroopa kunstiprobleemid pärast Teist maailmasõda" Kumu Kunstimuuseumis 27. ja 28. IX. Esinejad: Irena Buzhinska, David Crowley, Branislav Dmitrijevic, Sirje Helme, Henry Meyric Hughes, Jaak Kangilaski, Liljana Kolesnik, Andres Kurg, Vojtech Lahoda, Steven Mansbach, Pjotr Piotrowski, Stefanie Reetz, Susan E. Reid, Skaidra Trilupaite, Borut Vogelnik

  5. Adamson-Eric 100 : XX sajandi kunsti- ja kultuurilugu ühe inimsaatuse kaudu / Ülle Kruus

    Index Scriptorium Estoniae

    Kruus, Ülle

    2002-01-01

    Näitus "Adamson-Eric 100" Eesti Kunstimuuseumi Rüütelkonna hoones ja Adamson-Ericu muuseumis. Koostajad Ülle Kruus, Kersti Koll, Hanno Soans, kujundajad Leonhard Lapin (EKM), Jaak Soans (Adamson-Ericu muuseum). Adamson-Ericu teosed väljaspool Eestit ja Eestisse tagasi jõudnud tööd

  6. Muuseum - market? Bach või Meie Mees? / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2005-01-01

    28. septembril 2005. a. Rüütelkonna hoones toimunud avalikult arutelult muuseumi koha ja funktsiooni üle tänapäeva ühiskonnas. Vestlusringis Jaak Kangilaski, Rein Raud, Eha Komissarov, Merike Lang, Johannes Saar, Anders Härm, Sirje Helme jt

  7. Patarei ja Lennusadama ala planeering = Plan for the Patarei Fort and Lennusadam Port Area

    Index Scriptorium Estoniae

    2007-01-01

    Patarei ja Lennusadama ala mahulise planeerimise rahvusvaheline ideevõistlus 2007. aastal. Võistlustööd "Kolm õuna" (I preemia - Sverre Laanjärv, Ivar Lubjak), "Põhi" (II preemia - Tõnu Laanemäe, Jaak-Adam Looveer, Toomas Paaver, kaasautorid Indrek Järve ja Lauri Saar) ja "Kompass" (III preemia - Ott Kadarik ja Villem Tomiste, AB Kosmos)

  8. Vahutab nagu seep, aga puhtaks ei pese / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    2005-01-01

    Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Jaak Urmet, R. Vilbre jt. : režissöör Rene Vilbre : produtsent ja operaator Manfred Vainokivi : helilooja Kaspar Jancis : Parunid ja Vonid, Taska Film, Amrion 2005

  9. Klaasist võidusammas tuleb kõigi kirgede kiuste

    Index Scriptorium Estoniae

    2008-01-01

    Tallinna Harjumäele kavandatava Vabadussõja võidusamba projekteerib, valmistab ja püstitab Tšehhi klaasifirma Sans Souci oktoobri keskpaigaks. Monument on plaanis avada 28. novembril 2008. Kommenteerib Jaak Aaviksoo. Vaata ka juhtkirja "Ässitajad arhitektid" lk. 2

  10. Äpardunud sambameistrid said viimaks hundipassi / Urmas Jaagant, Tuuli Aug ; kommenteerinud Rainer Sternfeld

    Index Scriptorium Estoniae

    Jaagant, Urmas

    2009-01-01

    Tšehhi firma Sans Souci ei suutnud Vabadussõja võidusamba ristiosa valgustust rahuldaval määral tööle saada. Uue valguslahenduse leidmiseks on kaitseminister Jaak Aaviksoo palunud algatada riigihanke. Vabadussamba autori Rainer Sternfeldi arvamus tšehhide kehva töö kohta

  11. Eestikeelne doktoriõpe ähvardab kaduda / Eva Kübar

    Index Scriptorium Estoniae

    Kübar, Eva

    2005-01-01

    Eestikeelse doktoriõppe võimalikku kadumist kommenteerivad Tallinna Tehnikaülikooli õppeprorektor Jakob Kübarsepp, Tartu Ülikooli rektor Jaak Aaviksoo, Eesti Põllumajandusülikooli õppeprorektor Hardi Tullus ja Tallinna Ülikooli rektor Mati Heidmets

  12. DVD "Vesi peale" / Mari Peegel

    Index Scriptorium Estoniae

    Peegel, Mari, 1978-

    2008-01-01

    Lühiarvustus animafilmile "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : dubleerijad Harriet Toompere, Aarne Üksküla, Jaak Prints : Ameerika Ühendriigid (Dream Works) ja Suurbritannia (Aardman Animations) 2006

  13. ÜEKNi 2005. aasta peakoosolek : ESTO 2008, resolutsioon, uus esimees / foto: V. Sarapuu

    Index Scriptorium Estoniae

    2005-01-01

    8. - 9. aprillil 2005 New Yorgis toimunud Ülemaailmse Eesti Kesknõukogu peakoosolekul kinnitati Inglismaa Eestlaste Ühingu soovil ESTO 2008 toimumise kohaks Inglismaa. Kesknõukogu uueks esimeheks valiti Jaak Juhansoo, Juhan Simonsoni vääristati Kanada eestlaste teenetemärgiga

  14. 12. I avati Tallinna Linnagaleriis...

    Index Scriptorium Estoniae

    2005-01-01

    Müncheni Kunstvereini dokumentalistikaprojekt "Es ist schwer das Reale zu berühren". Kuraatorite Soren Grammeli ja Maria Lindi kokkupandud videoarhiivi kuulub 60 kunstniku ligi sada videot. Loetletud 16 skriiningutel osalenud kunstnikku (Eestist Mari Laanemets & Killu Sukmit). Festivalidel on Eestist osalenud veel Mark Raidpere ja Marko Raat. Avamisel kõnelesid Maria Lind ja Jaak Kilmi

  15. Tartlased lõid uut laadi tetrisemängu : eestlased pürivad miljarditurule / Kristiina Kruuse

    Index Scriptorium Estoniae

    Kruuse, Kristiina

    2010-01-01

    Uus iPhone´i mäng Wristbreaker, mille investorid on Sven Illingu ettevõte iCapital ja Mattias Linnap. Mängu loomisse on panustanud ka Gunnar Eelmäe, Jaak Ennuste ja Tartu Teaduspargis tegutsev ettevõte Indilo Wireless

  16. Jazz-muusikud tulevad kevadet tooma / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2009-01-01

    Pärnus Jazzkaare festivalil esinejatest: norra laulja Solveig Slettahjell 19. aprillil Eliisabeti kirikus, Hedvig Hanson kontserdiga "Rahvaste hällilaulud" 21. apr. Pärnu kontserdimajas, duo Jaak Sooäär - Tuule Kann 22. apr. Pärnu raekojas ja Andy Emleri trio 23. apr. Ammende villas. Jazzkaare festivali ajaloost korraldaja Anne Ermi sõnul

  17. Rasedad mehed Eesti tõsist dokumentalistikat ei ohusta / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2007-01-01

    Tartus Maailmafilmi festivali raames toimunud noorte loojate ümarlauast eesti dokumentalistika probleemidest (juhatas Anders Härm, osalesid Jaak Kilmi, Andres Maimik, Rain Tolk, Urmas E. Liiv, Eeva Kesküla). Lühidalt ka festivalil linastunud Liivo Niglase ja Frode Storaasi dokumentaalfilmist vihma loitsimisest Aafrikas "Vihmategemine" (Eesti - Norra - Mosambiik 2007)

  18. Kus ta siis ometi on - see Bob Dylan? / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2008-01-01

    Todd Haynes'i mängufilm muusik Bob Dylanist "Kus on Bob Dylan?" ("I'm Not There") : laulja alter ego kehastavad Ben Whishaw, Christian Bale, Heath Ledger, Cate Blanchett, Richard Gere, Marcus Carl Franklin : Ameerika Ühendriigid 2007. 4. juunil Saku Suurhallis toimuvast kontserdist. Jaak Johanson, Tõnis Mägi, Riho Sibul, Hannes Varblane ameerika lauljast

  19. Kleenexi ja Tampaxi pojad / Urmas Petti

    Index Scriptorium Estoniae

    Petti, Urmas, 1965-2016

    2013-01-01

    Laste ja noorte kasvamisest ja kasvatamisest tänapäeval, nende hakkamasaamisest üha keerulisemaks muutuvas ühiskonnas; autor tsiteerib Jaak Jõerüüti (romaan "Muutlik" 2010) ja kommenteerib argentiina kirjanikku Julio Cortázar'i ja briti kolumnisti võrdlevas usuteaduses Karen Armstrongi (raamat "Jumala ajalugu", orig. "A History of God" 1993)

  20. Estonian living in safest of times / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Peaminister Andrus Ansip ütles kevadisi riigikaitsekursuseid avades, et tema hinnangul elab Eesti julgeoleku seisukohalt oma ajaloo ilmselt kõige turvalisemat etappi, olles NATO ja Euroopa Liidu liige. Kursuste avamistseremooniast võtsid osa ka kaitseminister Jaak Aaviksoo, välisminister Urmas Paet, siseminister Marko Pomerants ja kaitseväe juhataja kindralleitnant Ants Laaneots

  1. Noored režissöörid väärtustavad eneseleidmist / Maiju Ingman, Anu Aun ; interv. Karin Klaus

    Index Scriptorium Estoniae

    Ingman, Maiju

    2007-01-01

    Pärnus näidatakse noortefilme : soomlanna Maiju Ingmani TÜ lõputööd "Mida iganes, Aleksander" (teekonnafilm, osades Jaak Prints, Arvo Kukumägi) ja Anu Auna lühifilmi "Indigo tuba" (mängivad Mirtel Pohla, Alo Kõrve). Režissöörid oma otsingutest ja filmidest

  2. Erna kostitas Jakobi malevkonna kaitseliitlasi muda, vee ja villidega / Urmas Hännile

    Index Scriptorium Estoniae

    Hännile, Urmas

    2003-01-01

    Pärnumaa maleva liikmete muljeid Erna retkest. Vt. samas intervjuud Erna retke staabiülema, Rootsi Kuningriigi kaitseväe kolonelleitnanti Jaak Kallaku ja Hiina Rahvavabariigi Soome saatkonna sõjaväeatashee, brigaadikindrali Liu Mengiga. Tabel: "Erna Retk 2003"

  3. Taas teadmusühiskonna infopoliitikast / Silvi Metsar

    Index Scriptorium Estoniae

    Metsar, Silvi

    2004-01-01

    RRis toimunud II infopoliitika foorumil "Riiklik infopoliitika - müüt või tegelikkus" arutleti, kas Eestis on infoühiskond, milline on riiklik infopoliitika jne. Teiste seas osalesid Anu Toots, Tiiu Valm, Peeter Tulviste, Jaak Aaviksoo, Raul Malmstein

  4. Täiskuu tervitas luulefestivali / Inge Põlma, Maire Kõrver

    Index Scriptorium Estoniae

    Põlma, Inge

    2008-01-01

    Ülevaade Täiskuu luulefestivalist, kus esinesid Kristiina Ehin, Andres Ehin, Ly Ehin, Contra, Sujata Bhatt, Ban'ya Natsuishi, Meelika Hainsoo, Lise Sinclair, Jaak Johanson, Lauri Õunapuu, Maria Peterson, Siiri Sisask, Kauksi Ülle, Sayumi Kamakura

  5. Eesti Hollywood ehk nädala jooksul tehakse kuut kodumaist filmi

    Index Scriptorium Estoniae

    2004-01-01

    Toimetus ja Eesti Filmi Sihtasutuse peaekspert Jaak Lõhmus töös olevatest mängufilmidest : Peeter Simmi "Kontserdireis", Peeter Urbla "Stiilipidu", Rene Vilbre "Röövlirahnu Martin", Õ-Fraktsiooni "Malev" (režissöör Kaaren Kaer)

  6. Eesti puidufirma laieneb Sri Lankale / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2004-01-01

    Eesti puidufirma Hapa Group alustab tootmist Sri Lankal, lootes suurendada kasumit odava toorme ja tööjõu kasutamise läbi. Lisa: Mõned faktid Hapa Groupi kohta. Diagramm: Tööjõud Sri Lankal 10 korda odavam. Kommenteerivad August Kull, Jaak Leimann, Ilmar Petersen ja Alar Kolk

  7. Nad on ärganud ja juba küpsed / Ilmar Raag

    Index Scriptorium Estoniae

    Raag, Ilmar, 1968-

    2000-01-01

    Pimedate Ööde Filmifestivalil esilinastusid lühimängufilm "Armas tuss 50 aastat hiljem" : režissöör René Vilbre : peaosades Lembit Eelmäe ja Herta Elviste : Allfilm 2000 ja dokumentaalfilm "Suur õde" : stsenaristid ja režissöörid Jaak Kilmi ja Andres Maimik : In-Ruum 2000

  8. "Karu süda" võistleb Anapa festivalil

    Index Scriptorium Estoniae

    2002-01-01

    Anapas toimub 5.-16. septembrini rahvusvaheline filmifestival "Kinošokk". Žüriisse kuulub ka Peeter Simm. Eestit esindab võistlusprogrammis Arvo Iho "Karu süda". Videofilmide programmis on Rene Vilbre "Armas tuss" ja Mark Soosaare "La Paloma", Jaak Kilmil on kaasas oma kuraatoriprogramm Balti alternatiivsetest lühifilmidest

  9. Sirbi tegijad läbi aegade

    Index Scriptorium Estoniae

    2004-01-01

    Toimetaja asetäitjad: Katrin Kivimaa, Reet Varblane jt. Kunst, arhitektuur: Alo Hoidre, Boris Lukats, Ressi Kaera, Jaak Olep, Ike Volkov, Mirjam Peil, Tiina Käesel, Katrin Kivimaa, Vappu Vabar, Reet Varblane, Mari Laaniste. Kunstnikud (arvutikujundus): Tõnu Soo, Ann Gornischeff, Gädvi Kuklase, Piia Ruber. Fotograafid: Solomon Rosenfeldt, Endel Köster, Kalju Suur, Arno Saar, Teet Malsroos

  10. The unique cultural voice : solo kannel, otsemaid / Olev Rood

    Index Scriptorium Estoniae

    Rood, Olev

    2007-01-01

    tutvustatakse Jaak Johansoni poolt Mäe talus Pringi külas Valgamaal salvestatud plaati kandlemängija ja -valmistaja Ilmar Tiidebergi muusikaga, kus plaadi 26 lugu on mängitud rahvamuusiku omavalmistatud kandlel (neid kokku on ta teinud üle 20)

  11. Sportimine taastab juhi väsinud vaimu / Sigrid Suu

    Index Scriptorium Estoniae

    Suu, Sigrid

    2003-01-01

    Juhtide vaimsest ja füüsilisest tervisest, stressi ennetamisest ja tagajärgedest ning sportimis- ja lõõgastumisviiside valikust. Kommenteerivad Remet AS-i juht Tõnu Altnurme ja E.L.L. Kinnisvara juht Jaak Vende

  12. Alates 13. XII on Vaala galeriis avatud "Talvesalong"

    Index Scriptorium Estoniae

    2004-01-01

    Väljas on Ellinor Aiki, Valdur Ohaka, Herman Talviku, Jaak Arro, Raoul Kurvitza, Andres Toltsi, Laurentsiuse, Lembit Saartsi, Rait Rosina, Merike Estna, Maarit Murka ning Aleksandr Breneri ja Barbara Schurzi tööd. 17. XII Anna Litvinova, Ilmar Kruusamäe ja Lembit Sarapuu ühised maaliseansid

  13. Tartu Ülikool esitleb juubelialbumit ja dokumentaalfilmi

    Index Scriptorium Estoniae

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitletakse ülikooli kohvikus kinkeraamatut "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  14. DVD-d. Universitas Tartuensis 375 / Rain Kooli

    Index Scriptorium Estoniae

    Kooli, Rain

    2007-01-01

    Lühiarvustus DVD-le Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilmist "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Estinfilm 2007

  15. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  16. Ülikooliga saab kohtuda ekraanil / Kerttu Jänese

    Index Scriptorium Estoniae

    Jänese, Kerttu, 1981-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilm "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Estinfilm 2007. Filmist räägivad tegijad

  17. Endiste tartlaste käekõrval kiirrongiga läbi 375-aastase Tartu Ülikooli ajaloo / Tõnis Arro

    Index Scriptorium Estoniae

    Arro, Tõnis, 1960-

    2011-01-01

    Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilm "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Tartu Ülikool, Estinfilm ja Eesti Rahvusringhääling, 2007

  18. Jazz festival offers mellow way to get into festive spirit / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2003-01-01

    Aafrika laulja Malia kontserdist Sakala keskuses 9. dets.; Jaak Sooääre ja taani kitarristi Pierre Dorge kontserdist Tallinna kunstihoones 4. dets.; Hedvig Hansoni ja Andre Maakeri kontserdist Niguliste kirikus 11. dets.; ameerika ansambli Gold Company Sextet kontsertidest Tallinnas 14. dets. ja Pärnus 15. dets. festivali Jõulujazz raames

  19. Õiguskantsleri arvates on peaminister rikkunud põhiseadust / Mati Määrits

    Index Scriptorium Estoniae

    Määrits, Mati, 1958-

    1994-01-01

    Eerik-Juhan Truuväli vastas Riigikogu liikme Jüri E. Põllu arupärimisele peaminister Mart Laari poolt 'Finest Hotel Groupi' laenu garanteerimise kohta ja K. Jaak Roosaare arupärimisele presidendi poolt ministrite vahetuse kinnitamata jätmise kohta, 21. veebruar 1994

  20. Täna selgub aasta film 2005

    Index Scriptorium Estoniae

    2006-01-01

    Eesti Filmiajakirjanike Ühing kuulutab välja Neitsi Maali filmiauhinna võitja. Nominendid on : "Afganistani armid" (rezh. Ivar Heinmaa), "Kuum külm sõda : Haukka grupp" (rezh. Rene Vilbre), "Kohtumine tundmatuga" (rezh. Jaak Kilmi), "Libahundi needus" (rezh. Rainer Sarnet), "Mees animatsioonist" (rezh. Hardi Volmer)

  1. Koole hakkavad haldama riiulifirmad / Toivo Tänavsuu, Vallo Toomet

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2006-01-01

    Kümme Tallinna kooli antakse 30 aastaks erafirmade renoveerida ja hallata. 32. keskkooli majandusjuhi Ants Ivaski, Kalev REC juhatuse liikme Peeter Lillestiku, U. S. Investi juhatuse liikme Tarmo Tomaki, RKAS-i juhi Jaak Saarniidu seisukohti. Vt. samas intervjuud Kaia Jäppineniga. Lisa: Rendisumma erineb mitu korda

  2. Linnaruum - kas ainult arhitektuur? / Mari-Liis Tammi-Kelder

    Index Scriptorium Estoniae

    Tammi-Kelder, Mari-Liis

    2004-01-01

    25. IV Tallinna Õpetajate Majas Eesti Kujurite Ühenduse seminar, mis keskendub monumentaalskulptuurile kaasaegses linnaruumis. Esinevad Bernard Gerboud Pariisist, Pekka Jylhä Soomest, Kristaps Gulbis ja Irena Buzinska Lätist, Jüri Soolep, Triin Ojari, Rael Artel, Jaan Elken ja Aili Vahtrapuu. Seminari juhatab Jaak Soans

  3. PÖFF-i filmiturul Baltic Event sünnivad tuleviku kinomagnetid / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    12. PÖFFiga kaasnes ka Tallinnas 30. novembrist 3. detsembrini toimunud filmiturg Baltic Event, millel stsenaariumi staadiumis olevad filmiprojektid otsivad maailma filmitööstuse esindajatest koostööpartnereid. Eestist osales Jaak Kilmi ja Artur Talviku projekt "Rahad ette"

  4. Kahekordne austusavaldus suurele hilinejale / Margit Urbel

    Index Scriptorium Estoniae

    Urbel, Margit

    2011-01-01

    Portreefilmid Lennart Merest: Jaak Lõhmuse (stsenarist ja režissöör) dokumentaalfilmist "Tantsud Linnuteele. Pildistusi Lennart Meri filmirännakutelt" (Estinfilm ja ERR, 2010) ja Arko Okki dokumentaalfilmist "Monoloogid 3D" ("Man Who Lived in Three-Dimensional Time", Acuba Film koostöös Uljana Kim Studio 2007-2011)

  5. Galeriid / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1999-01-01

    Allen Jonesi litograafiate näitus galeriis "Vaal". Paul Rodgersi projektist Tartus Vanas anatoomikumis. Aili Vahtrapuu "Vee ruum" ja Jaak Soansi "Projektsioonid" Kunstihoone galeriis. Skulptorite ühenduse ideenäitus "Akvaarium" Rotermanni soolalao keldrisaalis. Idee autor Terje Ojaver.

  6. Betoonkamakas rannamändide vahel / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2006-01-01

    Omapäraselt karm, ent loodusega kontakti otsiv luksuslik betoonist rannavilla Tallinna lähedal asuvas eramurajoonis. Villale lisavad läbipaistvust nurgapostideta nurgaaknad. Projekteerija: OÜ Eensalu & Pihel. Arhitektid Laur Pihel ja Tauno Aadma. Sisearhitekt Jaak Jõevee. Projekt 2004, valmis 2006. Ill.: I ja II korruse plaan, 4 värv. välis- ja 8 sisevaadet

  7. Drama Russkogo teatra : posledni akt / Jaanus Kukk, Jevgeni Golikov ; interv. Boris Tuch

    Index Scriptorium Estoniae

    Kukk, Jaanus

    2008-01-01

    Vene Teatri kunstiline juht Mihhail Tshumatshenko lahkus ametist. Vene teatri olukorrast räägivad ja avaldavad oma arvamust ka Aivar Mägi, Jaak Allik, Laine Jänes, Artjom Garejev, Aleksandr Ivashkevitsh, Julia Jablonskaja. Lühendatult on avaldatud Ugala teatri lavastaja Peeter Tammearu avalik pöördumine

  8. Rüütel nimetas ametisse neli suursaadikut

    Index Scriptorium Estoniae

    2006-01-01

    President Arnold Rüütel nimetas Jaak Jõerüüdi suursaadikuks Lätis, Mart Tarmaku suursaadikuks Portugalis, Aino Leppik von Wireni suursaadikuks Iisraelis ja Sander Soone suursaadikuks Lääne-Euroopa Liidu ning Euroopa Liidu poliitika- ja julgeolekukomitee juures Brüsselis. Allk.: BNS

  9. Konkurentsis kolme Eesti tudengi filmid / Maris Balbat

    Index Scriptorium Estoniae

    Balbat, Maris, 1936-

    2003-01-01

    PÖFFiga kaasneval tudengifilmide festivalil esindavad Eestit Mart Arjukese ja Kristjan Jaak Nuudi lühimängufilm "Duell"; Kristi Leppiku nukufilm "Narkissos" ja Andres Puustusmaa lühimängufilm "Pärast müra". Lisatud lühiintervjuud Mart Arjukese ja Kristi Leppiku ning žürii liikme Peeter Urblaga

  10. Eesti film kumab pimedas öös / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    1999-01-01

    III Pimedate Ööde Filmifestivalil esilinastuvad Eesti-Läti ühisprojekt "Kolm lugu", kus ka Ervin Õunapuu "Kõrbekuu" ja Peeter Simmi "Aida" ning rahvusvaheline videokassett "Identiteet", kus ka Jaak Kilmi lühifilm "Inimkaamera"

  11. Helsingi loomaaia jääskulptuuridest valiti parimad

    Index Scriptorium Estoniae

    2004-01-01

    Soomes Korgeasaaris lõppes jääskulptuurivõistlus. Võitjad. Esikohatöö autorid olid Steve Lester Ameerikast ja Ljudmila Lester Venemaalt. Eestist osalesid ühel võistlusel Lembit Palm ja Jaak Soans ning teisel võistlusel Tiiu Kirsipuu ja Aime Kuulbusch

  12. Isiklik puudutus Pärnust / Siram

    Index Scriptorium Estoniae

    Siram, pseud., 1968-

    2004-01-01

    Andrus Joonase kureeritud näitus "Kunst on halb, kunst on hea" Pärnu Uue Kunsti Muuseumis 20. X-20. XI. Mila Balti, Toomas Kuusingu, Asta Isaki, Pille Neeve, Remo Randveri, Ville-Karel Viirelaiu, Non Grata, Mark Soosaare, Svea Aaviku, Meeland Sepa, Andrus Joonase, Urmas Martinsoni, Kadri Alesmaa, Jaak Visnapi ja Viljar Kõivu töödest

  13. Postimees hääletas võitjaks Korea filmi "Tühi maja"

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindas 5-palli süsteemis viis asjatundjat : Sulev Teinemaa, Kristiina Davidjants, Olev Remsu, Jaak Allik Ja Giuseppe Gariazzo. Kõik esitavad oma hinnangu lühikokkuvõtte. Lisatud lõplik tabel

  14. Staff

    Index Scriptorium Estoniae

    2006-01-01

    TÜ teadustöötajaist ja õppejõududest on 2/3 doktorikraadiga. TÜ rektor Jaak Aaviksoo ja teadusprprektor Ain Heinaru valiti Euroopa kõrghariduspoliitika juhtorganitesse. Sotsiaalteaduskonna prof. Wolfgang Drechsler sai Saksa-Eesti akadeemiliste suhete arendamise eest Saksamaa Liitvabariigi Teeneteristi

  15. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Fort Minor "The Rising Tied", KT Tunstall "Eye To The Telescope", David Bowie "The Platinum Collection", Beats And Styles "Everything Is Everything", Mikko Innanen, Jaak Sppäär and Han Bennink "Spring Odyssey", RinneRadio, Tok Tok Tok "A Wish"

  16. Hiirele vesi peale / Timo Diener

    Index Scriptorium Estoniae

    Diener, Timo

    2006-01-01

    Animakomöödia "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : eestikeelse dublaazhi režissöör Janno Põldma : rotipoiss Roddy rolli dubleerija Jaak Prints : Ameerika Ühendriigid - Suurbritannia 2006 (stuudiod DreamWorks ja Aardman)

  17. Kempsupotist alla lastud hiir räägib eesti keelt / Triin Tael

    Index Scriptorium Estoniae

    Tael, Triin

    2006-01-01

    Animakomöödia "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : eestikeelse dublaazhi režissöör Janno Põldma : rotipoiss Roddy rolli dubleerija Jaak Prints : Ameerika Ühendriigid - Suurbritannia 2006 (stuudiod DreamWorks ja Aardman)

  18. Riigijuhtide riskialdis õhulend / Oliver Rand

    Index Scriptorium Estoniae

    Rand, Oliver, 1971-

    2007-01-01

    President Toomas Hendrik Ilves, Riigikogu esimees Ene Ergma, kaitseminister Jaak Aaviksoo, kaitseväe juhataja Ants Laaneots, Riigikogu riigikaitsekomisjoni esimees Mati Raidma koos kaaskonnaga lendasid USA lennukikandjale USS Enterprise ühes lennukis. Riigi võtmeisikute üheskoos reisimisega kaasnevatest turvariskidest. Vt. samas: Mujal karmimad meetmed

  19. Elamusi ujuvast linnast / Krister Kivi

    Index Scriptorium Estoniae

    Kivi, Krister, 1975-

    2007-01-01

    Reportaaž Eesti presidendi Toomas Hendrik Ilvese külaskäigust maailma pikimale ja maailma esimesele tuumajõul töötavale lennukikandjale USS Enterprise. Delegatsiooni kuulusid veel Riigikogu esimees Ene Ergma, kaitseväe juht Ants Laaneots, kaitseminister Jaak Aaviksoo, Riigikogu liikmed Sven Mikser ja Mati Raidma ning USA suursaadik Eestis Stanley Davis Phillips

  20. Tartu abiturientide elu võimalus: päev Ühendriikide sõjalaeva pardal / Mari-Liis Pintson

    Index Scriptorium Estoniae

    Pintson, Mari-Liis

    2017-01-01

    USA suursaadik James D. Melville juunior tegi Tartu Kristjan Jaak Petersoni gümnaasiumi kooliperele üllatuse ja kutsus rühma abituriente sel nädalal Tallinnas viibiva Ameerika Ühendriikide sõjalaeva USS Hué City pardale.

  1. Naturen i den estniska poesin : från animism och panteism till zenbuddhism / Andres Ehin

    Index Scriptorium Estoniae

    Ehin, Andres, 1940-2011

    2001-01-01

    Orig.: Loodus eesti luules: animismist ja panteismist kuni zen-buddhismini. Tekstis on rootsikeelseid luulenäiteid järgmiste eesti luuletajate loomingust: Kristjan Jaak Peterson, Karl Eduard Sööt, Ernst Enno, Gustav Suits, Henrik Visnapuu, Villem Ridala, Betti Alver, Uku Masing, Bernard Kangro, Kalju Lepik, Ilmar Laaban, Artur Alliksaar ja Hando Runnel.

  2. MicroRNA-205 downregulates mixed-lineage-AF4 oncogene expression in acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Dou L

    2013-08-01

    Full Text Available Liping Dou,1,* Jingxin Li,1,* Dehua Zheng,2,* Yonghui Li,1 Xiaoning Gao,1 Chengwang Xu,1 Li Gao,1 Lili Wang,1 Li Yu1 1Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of Hepatobiliary Surgery, Organ Transplant Center, Chinese PLA 309th Hospital, Beijing, People's Republic of China*These authors contributed equally to this workAbstract: Myeloid/lymphoid or mixed-lineage AF4 acute lymphoblastic leukemia (MLL-AF4 ALL is a pediatric leukemia that occurs rarely in adults. MLL-AF4 ALL is typically characterized by the presence of chromosomal translocation (t(4;11(q21;q23, leading to expression of MLL-AF4 fusion protein. Although MLL-AF4 fusion protein triggers a molecular pathogenesis and hematological presentations that are unique to leukemias, the precise role of this oncogene in leukemogenesis remains unclear. Previous studies have indicated that microRNAs (miRs might modulate the expression of MLL-AF4 ALL fusion protein, thereby suggesting the involvement of miR in progression or suppression of MLL-AF4 ALL. We have previously demonstrated that miR-205 negatively regulates transcription of an MLL-AF4 luciferase reporter. Here, we report that exogenous expression of miR-205 in MLL-AF4 human cell lines (RS4;11 and MV4-11 inversely regulates the expression of MLL-AF4 at both messenger RNA (mRNA and protein level. Furthermore, miR-205 significantly induced apoptosis in MLL-AF4 cells as evidenced by Annexin V staining using fluorescence-activated cell sorting (FACS analysis. The proliferative capacity of leukemic cells was suppressed by miR-205. The addition of an miR-205 inhibitor was able to restore the observed effects. In conclusion, these findings demonstrate that miR-205 may have potential value as a novel therapeutic agent in the treatment of MLL-AF4 ALL.Keywords: miR-205, MLL-AF4, leukemia, microRNA, oncogene expression, untranslated regions, proliferation

  3. Focusing performance of a multilayer Laue lens with layer placement error described by dynamical diffraction theory.

    Science.gov (United States)

    Hu, Lingfei; Chang, Guangcai; Liu, Peng; Zhou, Liang

    2015-07-01

    The multilayer Laue lens (MLL) is essentially a linear zone plate with large aspect ratio, which can theoretically focus hard X-rays to well below 1 nm with high efficiency when ideal structures are used. However, the focusing performance of a MLL depends heavily on the quality of the layers, especially the layer placement error which always exists in real MLLs. Here, a dynamical modeling approach, based on the coupled wave theory, is proposed to study the focusing performance of a MLL with layer placement error. The result of simulation shows that this method can be applied to various forms of layer placement error.

  4. Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

    DEFF Research Database (Denmark)

    Sausen, Mark; Phallen, Jillian; Adleff, Vilmos

    2015-01-01

    tumour-specific mutations in the circulation of these patients. These analyses reveal somatic mutations in chromatin-regulating genes MLL, MLL2, MLL3 and ARID1A in 20% of patients that are associated with improved survival. We observe alterations in genes with potential therapeutic utility in over...... a third of cases. Liquid biopsy analyses demonstrate that 43% of patients with localized disease have detectable circulating tumour DNA (ctDNA) at diagnosis. Detection of ctDNA after resection predicts clinical relapse and poor outcome, with recurrence by ctDNA detected 6.5 months earlier than with CT...

  5. Innovation in the management of lessons learned in an IT project with the adoption of social media

    Directory of Open Access Journals (Sweden)

    Roberto Winter

    2017-03-01

    Full Text Available This research explores the gap in the management of lessons learned (MLL in an Information Technology project (IT, validating a model (named Target with the support of a wiki platform in a medium-sized company in the IT industry. This model supports the following MLL processes: awareness, collection, verification, storage, dissemination and reuse. This study adopts the paradigm of the Design Science Research and the Technical Action Research method to instantiate the Target model in the implementation phase of an IT project. The theoretical contribution lies in the practical utility of an LL model, which was validated in the field promoting innovation in the MLL. The practical implications can be seen in the company's learning to introduce the MLL, improve design productivity, increase employee collaboration and better disseminate knowledge.

  6. Can a Morel-Lavallée lesion be misdiagnosed as a mass like lesion?

    Science.gov (United States)

    Lee, Yoon Jae; Kim, Jun Hyeok; Kim, Ji Young; Han, Hyun Ho

    2017-12-01

    The Morel-Lavallée lesion (MLL) is a post-traumatic closed soft tissue degloving injury. Common complaints of MLL patients are a haematoma or fluid collection on the trunk or the lower extremity. However, the authors introduce unique cases of MLL that present an atypical appearance. The fluid collection was not apparent, and the capsule formation was not detected on preoperative image study. The main complaint of patients was the uncomfortable mass-like lesion that was regarded as a simple benign lump. The purpose of this case study is to introduce the atypical cases of MLL and to help other physicians make accurate diagnosis based on trial and error of our cases. © 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  7. Bonded Multilayer Laue Lens for focusing hard X-rays

    International Nuclear Information System (INIS)

    Liu Chian; Conley, R.; Qian, J.; Kewish, C.M.; Macrander, A.T.; Maser, J.; Kang, H.C.; Yan, H.; Stephenson, G.B.

    2007-01-01

    We have fabricated partial Multilayer Laue Lens (MLL) linear zone plate structures with thousands of alternating WSi 2 and Si layers and various outermost zone widths according to the Fresnel zone plate formula. Using partial MLL structures, we were able to focus hard X-rays to line foci with a width of 30 nm and below. Here, we describe challenges and approaches used to bond these multilayers to achieve line and point focusing. Bonding was done by coating two multilayers with AuSn and heating in a vacuum oven at 280-300 o C. X-ray reflectivity measurements confirmed that there was no change in the multilayers after heating to 350 o C. A bonded MLL was polished to a 5-25 μm wedge without cracking. SEM image analyses found well-positioned multilayers after bonding. These results demonstrate the feasibility of a bonded full MLL for focusing hard X-rays

  8. Characterization of a multilayer Laue lens with imperfections

    International Nuclear Information System (INIS)

    Yan, H.; Kang, H.C.; Maser, J.; Macrander, A.T.; Kewish, C.M.; Liu, C.; Conley, R.; Stephenson, G.B.

    2007-01-01

    We present a simulation result of the focusing performance of a multilayer Laue lens (MLL) with imperfections. Imperfections we have studied correspond to deviations of sequence of layers in the fabricated structure from the zone plate law. The actual sequence of layers of the MLL is measured by scanning electron microscope (SEM), and fitted by second order polynomials. X-ray characterization of the MLL structures is performed using coherent X-rays at the Advanced Photon Source. We observe very good agreement between experiment and simulation. This demonstrates that our simulation method can serve as an efficient tool to characterize the focusing performance of MLLs with imperfections, and thereby allows us to provide feedback following deposition and fabrication of the MLL structures and optimization of focusing structures prior to X-ray characterization

  9. (Mycosphaerella fijiensis Morelet) chez le bananier plantain

    African Journals Online (AJOL)

    SARAH

    31 mars 2014 ... gratissimum and sprayed sprayed in a mixture with banole oil at 5 ml/l. The application of ..... Cymbopogon citratus à inhiber la croissance des appressoria de ... American Perfumer & Essential Oil Review,. 1928, 467-503.

  10. Focusing of hard x-rays to 16 nanometers with a multilayer Laue lens

    International Nuclear Information System (INIS)

    Kang, Hyon Chol; Yan Hanfei; Winarski, Robert P.; Holt, Martin V.; Maser, Joerg; Liu Chian; Conley, Ray; Vogt, Stefan; Macrander, Albert T.; Stephenson, G. Brian

    2008-01-01

    We report improved results for hard x-ray focusing using a multilayer Laue lens (MLL). We have measured a line focus of 16 nm width with an efficiency of 31% at a wavelength λ=0.064 nm (19.5 keV) using a partial MLL structure with an outermost zone width of 5 nm. The results are in good agreement with the theoretically predicted performance

  11. Use of Sodium Hypochlorite for the Control of Bakanae Disease in Rice

    OpenAIRE

    Dong Bum Shin; Jaeduk Goh; Bong Choon Lee; In Jeong Kang; Hang-Won Kang

    2014-01-01

    For application of sodium hypochlorite as a seed disinfectant to the control of bakanae disease caused by Gibberella fujikuroi in rice, we investigated the effects of sodium hypochlorite for antifungal activity, eliminating fungus from seeds and reducing disease occurrence in vitro and greenhouse. The viability of the pathogen was significantly reduced at 80 ml/l concentration of sodium hypochlorite, and the pathogens did not grow at over 100 ml/l concentration of sodium hypochlor...

  12. Multilayer Laue Lens: A Path Toward One Nanometer X-Ray Focusing

    International Nuclear Information System (INIS)

    Yan, H.; Stephenson, G.B.; Maser, J.; Yan, H.; Conley, R.; Kang, H.C.; Stephenson, G.B.; Kang, H.C.; Maser, J.; Conley, R.; Liu, Ch.; Macrander, A.T.

    2010-01-01

    The multilayer Laue lens (MLL) is a novel diffractive optic for hard X-ray nano focusing, which is fabricated by thin film deposition techniques and takes advantage of the dynamical diffraction effect to achieve a high numerical aperture and efficiency. It overcomes two difficulties encountered in diffractive optics fabrication for focusing hard X-rays: (1) small outmost zone width and (2) high aspect ratio. Here, we will give a review on types, modeling approaches, properties, fabrication, and characterization methods of MLL optics. We show that a full-wave dynamical diffraction theory has been developed to describe the dynamical diffraction property of the MLL and has been employed to design the optimal shapes for nano focusing. We also show a 16 nm line focus obtained by a partial MLL and several characterization methods. Experimental results show a good agreement with the theoretical calculations. With the continuing development of MLL optics, we believe that an MLL-based hard x-ray microscope with true nanometer resolution is on the horizon

  13. Effect of Post-Harvest Acetic Acid and Plant Essential Oils on Shelf-Life Extension of Tomato Fruits

    International Nuclear Information System (INIS)

    Salem, E.A.; Naweto, M.; Mostafa, M.

    2013-01-01

    In vitro effect of different concentrations of acetic acid on linear growth of Alternaria alternate was studied. The causal agent of tomato black rots in contact and fumigation showed that acetic acid inhibit A. alternata growth at 2 ml/L and on 0.8 ml/L in contact and fumigation, respectively. In vivo effect showed that acetic acid at 6 ml/L reduced severity of infection of tomato fruits from 53.5% to 4.8% after 3 weeks of storage in dipping method but at the strongest fumigation methods, acetic acid inhibit tomato fruits rot at 0.4 ml/L after 3 weeks of storage. In vitro effect of camphore (Eucalyptus globulus Labill), caraway (Carium carvum L.) and peppermint oil (Mentha piperita L.) at different concentrations were tested against Alternaria alternata, since caraway oil is the strongest oil effect on fungal growth followed by peppermint and camphore respectively. Similarly in in vivo caraway oil inhibit tomato fruits rots at 6 ml/L followed by peppermint that inhibited tomato rots at 8 ml / L but camphore reduced tomato rots at 8 ml/L from 40% to 8.1%. Accepted April 2013

  14. Guanicid and PHMG Toxicity Tests on Aquatic Organisms

    Directory of Open Access Journals (Sweden)

    Eva Poštulková

    2016-01-01

    Full Text Available The emergence and development of new algicidal products is caused by the ever increasing popularity of garden ponds as well as the use of these products in the fisheries sector, especially for disposal of cyanobacteria and algae. Most frequent means of combating cyanobacteria and algae are applications of algicidal substances. Newly developed algaecides include Guanicid and polyhexamethylene guanidine hydrochloride (PHMG. The aim of the study was to identify toxic effects of Guanicid and PHMG on zebrafish (Danio rerio and green algae (Desmodesmus communis. We determined the acute toxicity in fish according to ČSN EN ISO 7346-1, and conducted the freshwater algae growth inhibition test according to ČSN ISO 8692 methodology. For inhibition tests with green algae we chose Guanicid and PHMG concentrations of 0.001, 0.005, and 0.010 ml/L. For fish short-term acute toxicity tests we chose Guanicid concentrations of 0.010, 0.050, 0.150, 0.200, 0.250, and 0.300 ml/L and PHMG concentrations of 0.010, 0.025, 0.050, 0.075, 0.100, and 0.125 ml/L. In case of zebrafish (Danio rerio, the LC50 value for Guanicid is 0.086 ml/L, while the LC50 value for PHMG is 0.043 ml/L. Effects of Guanicid on inhibition of green algae (Desmodesmus communis appear highly significant (p < 0.010 at a concentration of 0.010 ml/L. For PHMG, these effects are highly significant (p < 0.001 at concentrations of 0.005 and 0.010 ml/L in 48 hours.

  15. Riigikokku pääseb läbi kolme sõela / Marko Suurmägi

    Index Scriptorium Estoniae

    Suurmägi, Marko, 1975-

    2007-01-01

    Kui iga erakonna üleriigilise nimekirja järjestus jääb samaks ka pärast valimisi, siis piirkondlik reastatakse pärast tulemuste selgumist saadud häälte arvu järgi ümber. Nii kerkib iga partei kõige rohkem hääli saanud liige esimeseks ja vähim toetust leidnud kandidaat viimaseks. Lisa: Võimalused. Isamaa ja Res Publica Liidu kandidaadi Helir-Valdor Seedri ja Rahvaliidu kandidaadi Jaak Alliku arvamus. Vt. samas lühiinter. valimistel osalevate erakondade esindajate Priit Toobali (Keskerakond), Meelis Atoneni (Reformierakond), Jaak Alliku (Rahvaliit), Helir-Valdor Seedri (Isamaa ja Res Publica Liit), Heiki Järveveeri (Sotsiaaldemokraatlik Erakond), Tanel Tammeti (Erakond Eestimaa Rohelised) ja Valentine Alvrega (Eesti Kristlikud Demokraadid)

  16. Vratshi i medsestrõ... za bortom peregovorov / Anna Litvinjuk

    Index Scriptorium Estoniae

    Litvinjuk, Anna

    2007-01-01

    Eesti Arstide Liit ja Eesti Keskastme Tervishoiutöötajate Kutseliit ei kiida heaks lepingut, mis kehtib vaid Haiglate Liidu liikmetele ja jätab palgatõusust ilma terve rea tervishoiutöötajaid. Tervishoiutöötajad pöörduvad kohtusse. Vt. samas: Kokkuvõtteks; Kommenteerivad: Eesti Arstide Liit, sotsiaalminister Jaak Aab, riiklik lepitaja Henn Pärn

  17. Inimesed, kes on armunud filmi / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2001-01-01

    UNICA festivali korraldaja Jaak Järvise abiga antud ülevaade Tallinnas 3.-12. augustini toimuvast UNICA 63. ülemaailmsest amatöörfilmide festivalist. Ka nimekiri selle raames toimunud üheminutiliste filmide maailmameistrivõistluste tulemustest, kus ühe kolmanda preemia sai Tõnu Aru ja Eve Esteri "Friendly". Põhiprogrammis võistleb ka Tõnu Aru "Elu on niisugune"

  18. Mida tegi peaminister Ansip 20 aastat tagasi? / Tarmo Vahter

    Index Scriptorium Estoniae

    Vahter, Tarmo, 1970-

    2007-01-01

    Endine Tartu KEK-i juhataja Jaak Kalm ja Tartu linna täitevkomitee aseesimees Robert Närska 1988. a. 2. veebruari meeleavaldusest ja selle laialiajamisest Tartus. Andrus Ansipi väidetavast kommentaarist meeleavalduse laialiajamisel. Peaminister Andrus Ansipi vastuseid küsimustele, miks EKP Tartu rajoonikomitee ei valinud teda 1988. a. rajoonikomitee II sekretäriks; kus ta viibis 2. veebruaril 1988. Lisa: Mida näitavad dokumendid

  19. PÖFFil võidutses Aasia / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2005-01-01

    Auhinnad IX PÖFFi Euraasia võistlusprogrammi filmidele. Grand prix läks hiina filmile "Shanghai unistus" (režii Wang Xiaoshuai). Žürii liikmed Eva Isaksen, Thomas Mauch, Jaak Allik, Sven Grünberg avaldavad lühiarvamusi. Lisatud nimekiri "9. Pimedate Ööde filmifestival andis välja järgmised auhinnad"

  20. Kolm küsimust esimese leedi kandidaatidele

    Index Scriptorium Estoniae

    2001-01-01

    Tiia Tulviste, Kirsti Savi, Sirje Priimägi, Mari-Ann Kelam ja Mari Tarand vastavad küsimustele, kuidas nad suhtuvad sattumisse presidendikampaaniasse, millisena nad näevad enda rolli presidendivalimiste kampaanias ja mida nad tahaksid teha esimese leedina. Eesti presidendi abikaasa rollist ühiskonnast räägivad Jaak Allik, Enn Eesmaa, Toomas Tiivel, Vilja Savisaar ja Gunnar Paal. Parlamendisaadik (M.-A. Kelam)