Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL

Energy Technology Data Exchange (ETDEWEB)

Do, To Uyen [Graduate Group in Immunology, University of California Davis, Davis, CA 95616 (United States); Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States); Ho, Bay; Shih, Shyh-Jen [Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States); Vaughan, Andrew, E-mail: Andrew.vaughan@ucdmc.ucdavis.edu [Graduate Group in Immunology, University of California Davis, Davis, CA 95616 (United States); Department of Radiation Oncology, University of California Davis, Sacramento CA 95817 (United States)

2012-12-15

Highlights: ► A Zinc Finger Nuclease (ZFN) targeting a leukemogenic hot spot for rearrangement in MLL is created. ► The novel ZFN efficiently cleaves MLL exon 13. ► Despite MLL cleavage and evidence of mis-repair, no leukemogenic translocations were produced. ► MLL cleavage alone is insufficient to generate leukemogenic translocations. - Abstract: Radiation treatment or chemotherapy has been linked with a higher risk of secondary cancers such as therapy related Acute Myeloid Leukemia (tAML). Several of these cancers have been shown to be correlated to the introduction of double stranded breaks (DSB) and rearrangements within the Mixed Lineage Leukemia (MLL) gene. We used Zinc Finger Nucleases (ZFNs) to introduce precise cuts within MLL to examine how a single DNA DSB might lead to chromosomal rearrangements. A ZFN targeting exon 13 within the Breakpoint Cluster Region of MLL was transiently expressed in a human lymphoblast cell line originating from a CML patient. Although FISH analysis showed ZFN DSB at this region increased the rate of MLL fragmentation, we were unable to detect leukemogenic rearrangements or translocations via inverse PCR. Interestingly, gene fragmentation as well as small interstitial deletions, insertions and base substitutions increased with the inhibition of DNA-PK, suggesting repair of this particular DSB is linked to non-homologous end joining (NHEJ). Although mis-repair of DSBs may be necessary for the initiation of leukemogenic translocations, a MLL targeted DNA break alone is insufficient.

The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

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Bibhu P. Mishra

2014-05-01

Full Text Available Despite correlations between histone methyltransferase (HMT activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4 methyltransferase critical for maintaining hematopoietic stem cells (HSCs. Here, we show that the SET domain, and thus HMT activity of MLL1, is dispensable for maintaining HSCs and supporting leukemogenesis driven by the MLL-AF9 fusion oncoprotein. Upon Mll1 deletion, histone H4 lysine 16 (H4K16 acetylation is selectively depleted at MLL1 target genes in conjunction with reduced transcription. Surprisingly, inhibition of SIRT1 is sufficient to prevent the loss of H4K16 acetylation and the reduction in MLL1 target gene expression. Thus, recruited MOF activity, and not the intrinsic HMT activity of MLL1, is central for the maintenance of HSC target genes. In addition, this work reveals a role for SIRT1 in opposing MLL1 function.

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.

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Herz, Hans-Martin; Mohan, Man; Garruss, Alexander S; Liang, Kaiwei; Takahashi, Yoh-Hei; Mickey, Kristen; Voets, Olaf; Verrijzer, C Peter; Shilatifard, Ali

2012-12-01

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancers. Although in yeast all H3K4 methylation patterns, including H3K4me1, are implemented by Set1/COMPASS (complex of proteins associated with Set1), there are three classes of COMPASS-like complexes in Drosophila that could carry out H3K4me1 on enhancers: dSet1, Trithorax, and Trithorax-related (Trr). Here, we report that Trr, the Drosophila homolog of the mammalian Mll3/4 COMPASS-like complexes, can function as a major H3K4 monomethyltransferase on enhancers in vivo. Loss of Trr results in a global decrease of H3K4me1 and H3K27ac levels in various tissues. Assays with the cut wing margin enhancer implied a functional role for Trr in enhancer-mediated processes. A genome-wide analysis demonstrated that Trr is required to maintain the H3K4me1 and H3K27ac chromatin signature that resembles the histone modification patterns described for enhancers. Furthermore, studies in the mammalian system suggested a role for the Trr homolog Mll3 in similar processes. Since Trr and mammalian Mll3/4 complexes are distinguished by bearing a unique subunit, the H3K27 demethylase UTX, we propose a model in which the H3K4 monomethyltransferases Trr/Mll3/Mll4 and the H3K27 demethylase UTX cooperate to regulate the transition from inactive/poised to active enhancers.

The incidence and distribution characteristics of MLL rearrangements in Chinese acute myeloid leukemia patients by multiplex nested RT-PCR.

Science.gov (United States)

Yang, Hua; Cao, Tingting; Gao, Li; Wang, Lili; Zhu, Chengying; Xu, Yuanyuan; Jing, Yu; Zhu, Haiyan; Lv, Na; Yu, Li

2017-07-20

Occurrence of MLL (Mixed Lineage Leukemia) gene rearrangements indicates poor prognosis in acute myeloid leukemia (AML) patients. This is the first study to report the positive rate and distribution characteristics of MLL rearrangements in AML patients in north China. We used multiplex nested real time PCR (RT-PCR) to screen for incidence of 11 MLL rearrangements in 433 AML patients. Eleven MLL rearrangements included (MLL-PTD, MLL-AF9, MLL-ELL, MLL-AF10, MLL-AF17, MLL-AF6, MLL-ENL, MLL-AF1Q, MLL-CBP, MLL-AF1P, MLL-AFX1). There were 68 AML patients with MLL rearrangements, and the positive rate was 15.7%. MLL-PTD (4.84%) was detected in 21 patients, MLL-AF9 in 15, (3.46%), MLL-ELL in 10 (2.31%), MLL-AF10 in 8 (1.85%), MLL-AF1Q in 2 (0.46%), 3 cases each of MLL-AF17, MLL-AF6, MLL-ENL (0.69% each), a and single case each of MLL-CBP, MLL-AF1P, and MLL-AFX1 (0.23% each). The highest rate of MLL rearrangements was found in 24 patients with M5 subtype AML, occurring in 24 cases (35.3%). MLL rearrangements occurred in 21 patients with M2 subtype AML (30.9%), and in 10 patients with M4 subtype AML (14.7%). Screening fusion genes by multiplex nested RT-PCR is a convenient, fast, economical, and accurate method for diagnosis and predicting prognosis of AML.

Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

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Yoshiyuki Watanabe

Full Text Available MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study.We analyzed mutations of coding region and promoter methylation in MLL3 using 126 cases of colorectal cancer. We found two isoforms of MLL3 and DNA sequencing revealed frameshift and other mutations affecting both isoforms of MLL3 in colorectal cancer cells and 19 of 134 (14% primary colorectal samples analyzed. Moreover, frameshift mutations were more common in cases with microsatellite instability (31% both in CRC cell lines and primary tumors. The largest isoform of MLL3 is transcribed from a CpG island-associated promoter that has highly homology with a pseudo-gene on chromosome 22 (psiTPTE22. Using an assay which measured both loci simultaneously we found prominent age related methylation in normal colon (from 21% in individuals less than 25 years old to 56% in individuals older than 70, R = 0.88, p<0.001 and frequent hypermethylation (83% in both CRC cell lines and primary tumors. We next studied the two loci separately and found that age and cancer related methylation was solely a property of the pseudogene CpG island and that the MLL3 loci was unmethylated.We found that frameshift mutations of MLL3 in both CRC cells and primary tumor that were more common in cases with microsatellite instability. Moreover, we have shown CpG island-associated promoter of MLL3 gene has no DNA methylation in CRC cells but also primary tumor and normal colon, and this region has a highly homologous of pseudo gene (psiTPTE22 that was age relate DNA methylation.

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

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Thomas A. Milne

2012-09-01

Full Text Available Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis.

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

Energy Technology Data Exchange (ETDEWEB)

Ballabio, Erica; Milne, Thomas A., E-mail: thomas.milne@imm.ox.ac.uk [MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital Headington, Oxford OX3 9DS (United Kingdom)

2012-09-10

Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC) inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL) protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis.

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

International Nuclear Information System (INIS)

Ballabio, Erica; Milne, Thomas A.

2012-01-01

Epigenetics is often defined as the study of heritable changes in gene expression or chromosome stability that don’t alter the underlying DNA sequence. Epigenetic changes are established through multiple mechanisms that include DNA methylation, non-coding RNAs and the covalent modification of specific residues on histone proteins. It is becoming clear not only that aberrant epigenetic changes are common in many human diseases such as leukemia, but that these changes by their very nature are malleable, and thus are amenable to treatment. Epigenetic based therapies have so far focused on the use of histone deacetylase (HDAC) inhibitors and DNA methyltransferase inhibitors, which tend to have more general and widespread effects on gene regulation in the cell. However, if a unique molecular pathway can be identified, diseases caused by epigenetic mechanisms are excellent candidates for the development of more targeted therapies that focus on specific gene targets, individual binding domains, or specific enzymatic activities. Designing effective targeted therapies depends on a clear understanding of the role of epigenetic mutations during disease progression. The Mixed Lineage Leukemia (MLL) protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4. MLL is required for normal development, but is also mutated in a subset of aggressive human leukemias and thus provides a useful model for studying the link between epigenetic cell memory and human disease. The most common MLL mutations are chromosome translocations that fuse the MLL gene in frame with partner genes creating novel fusion proteins. In this review, we summarize recent work that argues MLL fusion proteins could function through a single molecular pathway, but we also highlight important data that suggests instead that multiple independent mechanisms underlie MLL mediated leukemogenesis

Initiation of MLL-rearranged AML is dependent on C/EBPα

DEFF Research Database (Denmark)

Ohlsson, Ewa; Hasemann, Marie Sigurd; Willer, Anton

2014-01-01

have compared gene expression profiles from human MLL-rearranged AML to normal progenitors and identified the myeloid tumor suppressor C/EBPα as a putative collaborator in MLL-rearranged AML. Interestingly, we find that deletion of Cebpa rendered murine hematopoietic progenitors completely resistant...

Järve Selver = Järve Selver / Jaak Huimerind

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Huimerind, Jaak, 1957-

2000-01-01

Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Konstruktiivne osa: Neoprojekt. I korruse avaliku tsooni värvilahendus sisearhitekt Mari Kurismaalt. Kauplused ja kontorid kujundas Tallinna Kaubamaja, toitlustuskohad\\\\ARS Interjöörprojekt. Projekt 1998-2000, valmis 2000. 9 ill.: korruste plaanid, välis- ja sisevaated

Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

Directory of Open Access Journals (Sweden)

Raquel Levón Herrera

2000-04-01

Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

The MLL recombinome of acute leukemias in 2017

DEFF Research Database (Denmark)

Meyer, C; Burmeister, T; Gröger, D

2018-01-01

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs)...... of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.Leukemia advance online publication, 8 August 2017; doi:10.1038/leu.2017.213....

MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.

Science.gov (United States)

Mater, David Van; Goodman, Barbara K; Wang, Endi; Gaca, Ana M; Wechsler, Daniel S

2012-04-01

Lymphoblastic lymphoma is the second most common type of non-Hodgkin lymphoma seen in children. Approximately, 90% of lymphoblastic lymphomas arise from T cells, with the remaining 10% being B-cell-lineage derived. Although T-cell lymphoblastic lymphoma most frequently occurs in the anterior mediastinum (thymus), B-cell lymphoblastic lymphoma (B-LBL) predominates in extranodal sites such as skin and bone. Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. MLL duplication/amplification has been described primarily in acute myeloid leukemia and myelodysplastic syndrome with no published reports of discrete MLL duplication/amplification events in B-LBL. The MLL gene duplication noted in this case may represent a novel mechanism for tumorigenesis in B-LBL.

Maarjamäe tallihoone äratamine = Waking of the Maarjamäe stables / Jaak Huimerind, Tarmo Piirmets ; intervjueerinud Katrin Koov

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Huimerind, Jaak, 1957-

2015-01-01

Intervjuu arhitekt Jaak Huimerinnaga ja sisearhitekt Tarmo Piirmetsaga Maarjamäe suvemõisa tallihoone restaureerimisest, millest sai Eesti Ajaloomuuseumi näitusteruum. Arhitektuur: Jaak Huimerind, Kadri Viltrop, Stuudio Paralleel. Sisearhitektuur: Tarmo Piirmets, PINK. Valmimisaasta: 2014

Materjalid muudavad maailma = Materials change the world / Jaak Kikas

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Kikas, Jaak

2005-01-01

Jaak Kikas TÜ materjaliteaduse instituudist mõnedest olulistest tendentsidest ja suundumustest uute materjalide otsingutel ning nendega kaasnevatest probleemidest. Materjaliteaduse artikli kommentaariks tutvustavad Kalle Komissarov (intervjueerija) ja Martin Pärn EKA disaini- ja tekstiilikateedri projekti "Arukate toodete disain - tuleviku eriala", millele saadi toetust SA Innove europrojektide raames

MLL2 mutation detection in 86 patients with Kabuki syndrome: a genotype-phenotype study.

Science.gov (United States)

Makrythanasis, P; van Bon, B W; Steehouwer, M; Rodríguez-Santiago, B; Simpson, M; Dias, P; Anderlid, B M; Arts, P; Bhat, M; Augello, B; Biamino, E; Bongers, E M H F; Del Campo, M; Cordeiro, I; Cueto-González, A M; Cuscó, I; Deshpande, C; Frysira, E; Izatt, L; Flores, R; Galán, E; Gener, B; Gilissen, C; Granneman, S M; Hoyer, J; Yntema, H G; Kets, C M; Koolen, D A; Marcelis, C l; Medeira, A; Micale, L; Mohammed, S; de Munnik, S A; Nordgren, A; Psoni, S; Reardon, W; Revencu, N; Roscioli, T; Ruiterkamp-Versteeg, M; Santos, H G; Schoumans, J; Schuurs-Hoeijmakers, J H M; Silengo, M C; Toledo, L; Vendrell, T; van der Burgt, I; van Lier, B; Zweier, C; Reymond, A; Trembath, R C; Perez-Jurado, L; Dupont, J; de Vries, B B A; Brunner, H G; Veltman, J A; Merla, G; Antonarakis, S E; Hoischen, A

2013-12-01

Recently, pathogenic variants in the MLL2 gene were identified as the most common cause of Kabuki (Niikawa-Kuroki) syndrome (MIM#147920). To further elucidate the genotype-phenotype correlation, we studied a large cohort of 86 clinically defined patients with Kabuki syndrome (KS) for mutations in MLL2. All patients were assessed using a standardized phenotype list and all were scored using a newly developed clinical score list for KS (MLL2-Kabuki score 0-10). Sequencing of the full coding region and intron-exon boundaries of MLL2 identified a total of 45 likely pathogenic mutations (52%): 31 nonsense, 10 missense and four splice-site mutations, 34 of which were novel. In five additional patients, novel, i.e. non-dbSNP132 variants of clinically unknown relevance, were identified. Patients with likely pathogenic nonsense or missense MLL2 mutations were usually more severely affected (median 'MLL2-Kabuki score' of 6) as compared to the patients without MLL2 mutations (median 'MLL2-Kabuki score' of 5), a significant difference (p < 0.0014). Several typical facial features such as large dysplastic ears, arched eyebrows with sparse lateral third, blue sclerae, a flat nasal tip with a broad nasal root, and a thin upper and a full lower lip were observed more often in mutation positive patients. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Minu kogemus: Facebook kui töö- ja õppevahend / Jaak Juske

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Juske, Jaak, 1976-

2015-01-01

Jaak Juske jaoks on FB hindamatu ühismälu kandja. Kuna ta paneb oma seinale pidevalt koos kommentaaridega üles vanu pilte, linke blogilugudele jne., siis hakkab see silma ka FB aktiivselt kasutatavatele noortele

HOXA9 is required for survival in human MLL-rearranged acute leukemias

NARCIS (Netherlands)

J. Faber (Joerg); A.V. Krivtsov (Andrei); M.C. Stubbs (Matthew); R. Wright (Renee); T.N. Davis (Tina); M.M. van den Heuvel-Eibrink (Marry); C.M. Zwaan (Christian Michel); A.L. Kung (Andrew); S.A. Armstrong (Scott)

2009-01-01

textabstractLeukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression

Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Science.gov (United States)

Aoki, Yuki; Watanabe, Takashi; Saito, Yoriko; Kuroki, Yoko; Hijikata, Atsushi; Takagi, Masatoshi; Tomizawa, Daisuke; Eguchi, Mariko; Eguchi-Ishimae, Minenori; Kaneko, Akiko; Ono, Rintaro; Sato, Kaori; Suzuki, Nahoko; Fujiki, Saera; Koh, Katsuyoshi; Ishii, Eiichi; Shultz, Leonard D.; Ohara, Osamu; Mizutani, Shuki

2015-01-01

Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34+CD38+CD19+ and CD34−CD19+ cells initiated leukemia, and in MLL-AF9 patients, CD34−CD19+ cells were LICs. In MLL-ENL patients, either CD34+ or CD34− cells were LICs, depending on the pattern of CD34 expression. In contrast, in patients with these MLL translocations, CD34+CD38−CD19−CD33− cells were enriched for normal hematopoietic stem cells (HSCs) with in vivo long-term multilineage hematopoietic repopulation capacity. Although LICs developed leukemic cells with clonal immunoglobulin heavy-chain (IGH) rearrangement in vivo, CD34+CD38−CD19−CD33− cells repopulated recipient bone marrow and spleen with B cells, showing broad polyclonal IGH rearrangement and recipient thymus with CD4+ single positive (SP), CD8+ SP, and CD4+CD8+ double-positive (DP) T cells. Global gene expression profiling revealed that CD9, CD32, and CD24 were over-represented in MLL-AF4, MLL-AF9, and MLL-ENL LICs compared with normal HSCs. In patient samples, these molecules were expressed in CD34+CD38+ and CD34− LICs but not in CD34+CD38−CD19−CD33− HSCs. Identification of LICs and LIC-specific molecules in primary human MLL-rearranged acute lymphoblastic leukemia may lead to improved therapeutic strategies for MLL-rearranged leukemia. PMID:25538041

TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

DEFF Research Database (Denmark)

Willer, Anton; Jakobsen, Janus Schou; Ohlsson, E

2015-01-01

orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid leukemia (AML). TGIF1/TGIF2 are relatively uncharacterized TALE transcription factors, which, in contrast to the remaining family, have been shown to act as transcriptional repressors. Given the general......Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which...... influence the clinical outcome. Collectively, these findings demonstrate that TALE family members can act both positively and negatively on transcriptional programs responsible for leukemic maintenance and provide novel insights into the regulatory gene expression circuitries in MLL-rearranged AML.Leukemia...

Zehn Oden / Kristjan Jaak Peterson ; [Deutsch von Gisbert Jänicke

Index Scriptorium Estoniae

Peterson, Kristian Jaak, 1801-1822

2001-01-01

On ilmunud ka kogumikus "Iaak. Kristian Jaak Peterson 200" (Tln. : Eesti Keele Sihtasutus, 2001, lk. 105-122). Sisu: Der Mond = Kuu ; Freundschaft = Sõprus ; Der Sänger = Laulja ; An Gott = Jumalale ; Hoffnung = Lootus ; Ich muss Trinken. Liedchen = Ma pean jooma. Lauluke ; Ich bin wieder glücklich = Olen jälle õnnis ; Der Mensch = Inimene ; Sonnenuntergang = Päeva loojaminemine ; Herbst = Sügise.

MLL/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly during Mitosis.

Science.gov (United States)

Ali, Aamir; Veeranki, Sailaja Naga; Chinchole, Akash; Tyagi, Shweta

2017-06-19

Mixed-lineage leukemia (MLL), along with multisubunit (WDR5, RbBP5, ASH2L, and DPY30) complex catalyzes the trimethylation of H3K4, leading to gene activation. Here, we characterize a chromatin-independent role for MLL during mitosis. MLL and WDR5 localize to the mitotic spindle apparatus, and loss of function of MLL complex by RNAi results in defects in chromosome congression and compromised spindle formation. We report interaction of MLL complex with several kinesin and dynein motors. We further show that the MLL complex associates with Kif2A, a member of the Kinesin-13 family of microtubule depolymerase, and regulates the spindle localization of Kif2A during mitosis. We have identified a conserved WDR5 interaction (Win) motif, so far unique to the MLL family, in Kif2A. The Win motif of Kif2A engages in direct interactions with WDR5 for its spindle localization. Our findings highlight a non-canonical mitotic function of MLL complex, which may have a direct impact on chromosomal stability, frequently compromised in cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

Energy Technology Data Exchange (ETDEWEB)

Huang, Jing; Gurung, Buddha; Wan, Bingbing; Matkar, Smita; Veniaminova, Natalia A.; Wan, Ke; Merchant, Juanita L.; Hua, Xianxin; Lei, Ming (Michigan); (Michigan-Med); (UPENN-MED)

2013-04-08

Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is characterized by tumorigenesis in multiple endocrine organs. Menin interacts with many proteins and is involved in a variety of cellular processes. Menin binds the JUN family transcription factor JUND and inhibits its transcriptional activity. Several MEN1 missense mutations disrupt the menin-JUND interaction, suggesting a correlation between the tumour-suppressor function of menin and its suppression of JUND-activated transcription. Menin also interacts with mixed lineage leukaemia protein 1 (MLL1), a histone H3 lysine 4 methyltransferase, and functions as an oncogenic cofactor to upregulate gene transcription and promote MLL1-fusion-protein-induced leukaemogenesis. A recent report on the tethering of MLL1 to chromatin binding factor lens epithelium-derived growth factor (LEDGF) by menin indicates that menin is a molecular adaptor coordinating the functions of multiple proteins. Despite its importance, how menin interacts with many distinct partners and regulates their functions remains poorly understood. Here we present the crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer. These structures show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but that it can have opposite effects on transcription. The menin-JUND interaction blocks JUN N-terminal kinase (JNK)-mediated JUND phosphorylation and suppresses JUND-induced transcription. In contrast, menin promotes gene transcription by binding the transcription activator MLL1 through the peptide pocket while still interacting with the chromatin-anchoring protein LEDGF at a distinct surface formed by both menin and MLL1.

A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia

International Nuclear Information System (INIS)

Cerveira, Nuno; Marschalek, Rolf; Teixeira, Manuel R; Meyer, Claus; Santos, Joana; Torres, Lurdes; Lisboa, Susana; Pinheiro, Manuela; Bizarro, Susana; Correia, Cecília; Norton, Lucília

2010-01-01

Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion genes have been cloned and characterized at the molecular level. In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia. Cytogenetics, fluorescence in situ hybridization (FISH), molecular studies (RT-PCR and LDI-PCR), and bioinformatic sequence analysis were used to characterize the CT45A2 gene as novel MLL fusion partner in pediatric acute leukemia. Fluorescence in situ hybridization of bone marrow G-banded metaphases demonstrated a cryptic insertion of 11q23 in Xq26.3 involving the MLL gene. Breakpoint fusion analysis revealed that a DNA fragment of 653 kb from 11q23, containing MLL exons 1-9 in addition to 16 other 11q23 genes, was inserted into the upstream region of the CT45A2 gene located at Xq26.3. In addition, a deletion at Xq26.3 encompassing the 3' region of the DDX26B gene (exons 9-16) and the entire CT45A1 gene was identified. RNA analysis revealed the presence of a novel MLL-CT45A2 fusion transcript in which the first 9 exons of the MLL gene were fused in-frame to exon 2 of the CT45A2 gene, resulting in a spliced MLL fusion transcript with an intact open reading frame. The resulting chimeric transcript predicts a fusion protein where the N-terminus of MLL is fused to the entire open reading frame of CT45A2. Finally, we demonstrate that all breakpoint regions are rich in long repetitive motifs, namely LINE/L1 and SINE/Alu sequences, but all breakpoints were exclusively identified outside these repetitive DNA sequences. We have identified CT45A2 as a novel spliced MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia, as a result of a cryptic insertion of 11q23 in Xq26.3. Since CT45A2 is the first Cancer/Testis antigen family gene

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

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Jakovcevski, Mira; Ruan, Hongyu; Shen, Erica Y; Dincer, Aslihan; Javidfar, Behnam; Ma, Qi; Peter, Cyril J; Cheung, Iris; Mitchell, Amanda C; Jiang, Yan; Lin, Cong L; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Akbarian, Schahram

2015-04-01

Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain largely unexplored. We report that neuronal ablation of the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal forebrain and adult prefrontal cortex (PFC) is associated with increased anxiety and robust cognitive deficits without locomotor dysfunction. In contrast, only mild behavioral phenotypes were observed after ablation of the Mll1 ortholog Kmt2b/Mll2 in PFC. Impaired working memory after Kmt2a/Mll1 ablation in PFC neurons was associated with loss of training-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity. Medial prefrontal layer V pyramidal neurons, a major output relay of the cortex, demonstrated severely impaired synaptic facilitation and temporal summation, two forms of short-term plasticity essential for working memory. Chromatin immunoprecipitation followed by deep sequencing in Mll1-deficient cortical neurons revealed downregulated expression and loss of the transcriptional mark, trimethyl-H3K4, at <50 loci, including the homeodomain transcription factor Meis2. Small RNA-mediated Meis2 knockdown in PFC was associated with working memory defects similar to those elicited by Mll1 deletion. Therefore, mature prefrontal neurons critically depend on maintenance of Mll1-regulated H3K4 methylation at a subset of genes with an essential role in cognition and emotion. Copyright © 2015 the authors 0270-6474/15/355097-12$15.00/0.

ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

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2014-01-01

Background Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphisms (SNPs) of IKZF1, ARID5B, and CEBPE could be related to the onset of EAL cases (diagnosis). Methods The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay. Logistic regression was used to evaluate the association between SNPs of cases and controls, adjusted on skin color and/or age. The risk was determined by calculating odds ratios (ORs) with 95% confidence interval (CI). Results Children with the IKZF1 SNP had an increased risk of developing MLL-germline ALL in white children. The heterozygous/mutant genotype in ARID5B rs10994982 significantly increased the risk for MLL-germline leukemia in white and non-white children (OR 2.60, 95% CI: 1.09-6.18 and OR 3.55, 95% CI: 1.57-8.68, respectively). The heterozygous genotype in ARID5B rs10821936 increased the risk for MLL-r leukemia in both white and non-white (OR 2.06, 95% CI: 1.12-3.79 and OR 2.36, 95% CI: 1.09-5.10, respectively). Furthermore, ARID5B rs10821936 conferred increased risk for MLL-MLLT3 positive cases (OR 7.10, 95% CI:1.54-32.68). Our data do not show evidence that CEBPE rs2239633 confers increased genetic susceptibility to EAL. Conclusions IKZF1 and CEBPE variants seem to play a minor role in genetic susceptibility to EAL, while ARID5B rs10821936 increased the risk of MLL-MLLT3. This result shows that genetic susceptibility could be associated with the differences regarding MLL breakpoints and partner genes. PMID:24564228

A novel RT-qPCR assay for quantification of the MLL-MLLT3 fusion transcript in acute myeloid leukaemia

DEFF Research Database (Denmark)

Abildgaard, Lotte; Ommen, Hans Beier; Lausen, Birgitte Frederiksen

2013-01-01

OBJECTIVES: Patients with acute myeloid leukaemia (AML) of the monocytic lineage often lack molecular markers for minimal residual disease (MRD) monitoring. The MLL-MLLT3 fusion transcript found in patients with AML harbouring t(9;11) is amenable to RT-qPCR quantification but because...... of the heterogeneity of translocation break points, the MLL-MLLT3 fusion gene is a challenging target. We hypothesised that MRD monitoring using MLL-MLLT3 as a RT-qPCR marker is feasible in the majority of patients with t(9;11)-positive AML. METHODS: Using a locked nucleic acid probe, we developed a sensitive RT......-qPCR assay for quantification of the most common break point region of the MLL-MLLT3 fusion gene. Five paediatric patients with t(9;11)-positive AML were monitored using the MLL-MLLT3 assay. RESULTS: A total of 43 bone marrow (BM) and 52 Peripheral blood (PB) samples were collected from diagnosis until...

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

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Schröter, David; Matthews, Helen C.; Bogani, Debora; Moir, Lee; Long, Anna; Church, Christopher; Hugill, Alison; Anstee, Quentin M.; Goldin, Rob; Thursz, Mark; Hollfelder, Florian; Cox, Roger D.

2013-01-01

We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes) died during embryonic development at 9.5–14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level. PMID:23826075

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

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Michelle Goldsworthy

Full Text Available We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7 gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes died during embryonic development at 9.5-14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level.

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.

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Rickels, Ryan; Hu, Deqing; Collings, Clayton K; Woodfin, Ashley R; Piunti, Andrea; Mohan, Man; Herz, Hans-Martin; Kvon, Evgeny; Shilatifard, Ali

2016-07-21

Polycomb response elements (PREs) are specific DNA sequences that stably maintain the developmental pattern of gene expression. Drosophila PREs are well characterized, whereas the existence of PREs in mammals remains debated. Accumulating evidence supports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of CGIs is selected to serve as PREs is unclear. Trithorax (Trx) positively regulates gene expression in Drosophila and co-occupies PREs to antagonize Polycomb-dependent silencing. Here we demonstrate that Trx-dependent H3K4 dimethylation (H3K4me2) marks Drosophila PREs and maintains the developmental expression pattern of nearby genes. Similarly, the mammalian Trx homolog, MLL1, deposits H3K4me2 at CpG-dense regions that could serve as PREs. In the absence of MLL1 and H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these loci. By inhibiting PRC2-dependent H3K27me3 in the absence of MLL1, we can rescue expression of these loci, demonstrating a functional balance between MLL1 and PRC2 activities at these sites. Thus, our study provides rules for identifying cell-type-specific functional mammalian PREs within the human genome. Copyright © 2016 Elsevier Inc. All rights reserved.

Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia

Czech Academy of Sciences Publication Activity Database

Čermáková, K.; Těšina, Petr; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Řezáčová, Pavlína; Veverka, Václav; De Rijck, J.

2014-01-01

Roč. 74, č. 18 (2014), s. 5139-5151 ISSN 0008-5472 R&D Projects: GA MŠk(CZ) LK11205; GA MŠk(CZ) 7E08066; GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : MLL * leukemia * LEDGF/p75 Subject RIV: CE - Biochemistry Impact factor: 9.329, year: 2014

Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia.

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Yin, Min; Chen, Zhiying; Ouyang, Yetong; Zhang, Huiyan; Wan, Zhigang; Wang, Han; Wu, Wei; Yin, Xiaoping

2017-06-29

Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial activation using an in vitro thrombin toxicity model applied to primary human microglia. A miRNA array identified 22 differential miRNA candidates. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) identified miR-181c as the most significantly downregulated miRNA. TargetScan analysis identified mixed lineage leukemia-1 (MLL1) as a putative gene target for miR-181c. qRT-PCR was applied to assess tumor necrosis factor-alpha (TNF-α), miR-181c, and MLL1 levels following thrombin or proteinase-activated receptor-4-specific activating peptide (PAR4AP) exposure. Anti-TNF-α antibodies and tumor necrosis factor receptor (TNFR) silencing were employed to test TNF-α/TNFR dependence. A dual-luciferase reporter system and miR-181c mimic transfection assessed whether mir-181c directly binds to and negatively regulates MLL1. Nuclear factor kappa-B (NF-κB)-dependent luciferase reporter assays and NF-κB target gene expression were assessed in wild-type (MLL1+) and MLL1-silenced cells. Thrombin or PAR4AP-induced miR-181c downregulation (p < 0.05) and MLL1 upregulation (p < 0.05) that were dependent upon TNF-α/TNFR. miR-181c decreased wild-type MLL1 3'-UTR luciferase reporter activity (p < 0.05), and a miR-181c mimic suppressed MLL1 expression (p < 0.05). Thrombin treatment increased, while miR-181c reduced, NF-κB activity and NF-κB target gene expression in both wild-type (MLL1+) and MLL1-silenced cells (p < 0.05). Thrombin-induced, TNF-α/TNFR-dependent miR-181c downregulation promotes MLL1 expression, increases NF-κB activity, and upregulates NF-κB target gene expression. As miR-181c opposes thrombin's stimulation of pro-inflammatory NF-κB activity, miR-181c mimic therapy may show promise in controlling thrombin

Teater - isiklikud või ühised asjad / Monika Läänesaar, Jaak Allik, Toomas Lõhmuste ; interv. Madis Kolk

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Läänesaar, Monika

2008-01-01

Vestlusringis kõnelevad 2007. aasta lõpul Tel Avivis toimunud Iisraeli draamafestivalist "Isra-Drama" Monika Läänesaar, Jaak Allik ja Toomas Lõhmuste. Festival tutvustab uut Iisraeli dramaturgiat, mis on tõlgitud inglise keelde

MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

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Sebastian, Soji; Sreenivas, Prethish; Sambasivan, Ramkumar; Cheedipudi, Sirisha; Kandalla, Prashanth; Pavlath, Grace K.; Dhawan, Jyotsna

2009-01-01

Most cells in adult tissues are nondividing. In skeletal muscle, differentiated myofibers have exited the cell cycle permanently, whereas satellite stem cells withdraw transiently, returning to active proliferation to repair damaged myofibers. We have examined the epigenetic mechanisms operating in conditional quiescence by analyzing the function of a predicted chromatin regulator mixed lineage leukemia 5 (MLL5) in a culture model of reversible arrest. MLL5 is induced in quiescent myoblasts and regulates both the cell cycle and differentiation via a hierarchy of chromatin and transcriptional regulators. Knocking down MLL5 delays entry of quiescent myoblasts into S phase, but hastens S-phase completion. Cyclin A2 (CycA) mRNA is no longer restricted to S phase, but is induced throughout G0/G1, with activation of the cell cycle regulated element (CCRE) in the CycA promoter. Overexpressed MLL5 physically associates with the CCRE and impairs its activity. MLL5 also regulates CycA indirectly: Cux, an activator of CycA promoter and S phase is induced in RNAi cells, and Brm/Brg1, CCRE-binding repressors that promote differentiation are repressed. In knockdown cells, H3K4 methylation at the CCRE is reduced, reflecting quantitative global changes in methylation. MLL5 appears to lack intrinsic histone methyl transferase activity, but regulates expression of histone-modifying enzymes LSD1 and SET7/9, suggesting an indirect mechanism. Finally, expression of muscle regulators Pax7, Myf5, and myogenin is impaired in MLL5 knockdown cells, which are profoundly differentiation defective. Collectively, our results suggest that MLL5 plays an integral role in novel chromatin regulatory mechanisms that suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. PMID:19264965

Rahumaa ja Raid ehitavad Balti riikide suurimat tööstuskontserni / Indrek Rahumaa, Jaak Raid ; interv. Mikk Salu

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Rahumaa, Indrek, 1972-

2007-01-01

Kalevi kompvekivabriku ja Tere piimatööstuse uued omanikud Indrek Rahumaa ja Jaak Raid vastavad küsimustele, mis puudutavad nende edasisi äri- ja investeeringuplaane. Vt. samas: Alta Capital Partners S.C.A.

Science of the Brain as a Gateway to Understanding Play: An Interview with Jaak Panksepp

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American Journal of Play, 2010

2010-01-01

Jaak Panksepp, known best for his work on animal emotions and coining the term "affective neuroscience," investigates the primary processes of brain and mind that enable and drive emotion. As an undergraduate, he briefly considered a career in electrical engineering but turned instead to psychology, which led to a 1969 University of…

Kas Balti teatrifestival jääb kestma? / Jaak Allik

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Allik, Jaak, 1946-

2006-01-01

Balti teatrifestivali "OmaDraama" esimees Jaak Allik teeb kokkuvõtteid festivalist ja nimetab laureaadid. Viis auhinda pälvisid eestlased - Mart Kivastik näidend "Põrgu Wärk", Hendrik Toompere näidendi lavastus, Harriet Toompere naisosatäitmine, Jan Uuspõld Wiiralti kehastamine, Margus Prangel Tuglase osa eest. Merle Karusoo "Misjonärid" sai auhinna järjepidevuse eest sotsiaalselt aktuaalsete probleemide tõstatamisel. Ülejäänud kaks auhinda said läti United Intimacy trupi lavastus "P:S. Pöialpoiss" ning leedu luuletaja ja näitleja Birut︠ Mar Salomeja Nerise kuju eest lavastuses "Poetess"

ÜEKN-i esimees Juhansoo : "Ostke ESTO 2009 pass, kas olete sellele sõitmas või mitte!" / Jaak Juhansoo ; interv. Jüri Estam

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Juhansoo, Jaak, 1942-2017

2009-01-01

Tallinnas 3. ja 4. aprillil 2009 toimunud Ülemaailmse Eesti Kesknõukogu sümpoosionist ja täiskogust räägib ÜEKN juhatuse esimehe kohale tagasivalitud Jaak Juhansoo, kes muuhulgas tunnustab president Toomas Hendrik Ilvese kõnet sümpoosionil. Ilmunud ka: Vaba Eesti Sõna 16. apr. 2009, lk. 3,10; Meie Kodu 22. apr. 2009, lk. 4; Eesti Päevaleht (Stockholm) 22. apr. 2009, lk. 4, pealk.: Ülemaailmne Eesti Kesknõukogu debüteeris istungiga Eestis; Eesti Rada, 2009, nr. 3, lk. 1,3, pealk.: Intervjuu ÜEKNi esimehe Jaak Juhansooga

Uued CO₂ kasukad vanadele majadele / Elari Udam ; intervjueerinud Margit Mutso ; kommenteerinud Peeter Pere, Oliver Orro, Jaak Huimerind

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Udam, Elari, 1968-

2011-01-01

Vabade CO₂ kvootide müügist laekunud raha eest renoveeritakse energiatõhusaks 480 Eesti hoonet. Projekti juhib Riigi Kinnisvara AS. Teemat selgitab RKASi juhatuse liige ja haldusdirektor Elari Udam, kommenteerivad Eesti Arhitektide Liidu esimees Peeter Pere, aseesimees Jaak Huimerind ja arhitektuuriajaloolane Oliver Orro

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.

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Trentin, Luca; Bresolin, Silvia; Giarin, Emanuela; Bardini, Michela; Serafin, Valentina; Accordi, Benedetta; Fais, Franco; Tenca, Claudya; De Lorenzo, Paola; Valsecchi, Maria Grazia; Cazzaniga, Giovanni; Kronnie, Geertruy Te; Basso, Giuseppe

2016-10-04

To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS and NRAS with incidences ranging from 25 to 50%. Whereas previous studies employed Sanger sequencing, here we used next generation amplicon deep sequencing for in depth evaluation of RAS mutations in 36 paediatric patients at diagnosis of MLL-AF4+ leukaemia. RAS mutations including those in small sub-clones were detected in 63.9% of patients. Furthermore, the mutational analysis of 17 paired samples at diagnosis and relapse revealed complex RAS clone dynamics and showed that the mutated clones present at relapse were almost all originated from clones that were already detectable at diagnosis and survived to the initial therapy. Finally, we showed that mutated patients were indeed characterized by a RAS related signature at both transcriptional and protein levels and that the targeting of the RAS pathway could be of beneficial for treatment of MLL-AF4+ BCP-ALL clones carrying somatic RAS mutations.

Järve Keskus : Tallinn, Pärnu mnt. 236 = Järve Centre : 236 Pärnu Rd., Tallinn / Jaak Huimerind

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Huimerind, Jaak, 1957-

2003-01-01

Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Kaastöötajad Kristi Põldme, Indrek Laos, Reet Viigipuu. Avalike ruumide sisekujundus: Mari Kurismaa. Konstruktiivne osa: E-Inseneribüroo. Projekt 2000-2002, valmis 2002. Asendi-, I ja II korruse plaan, 6 vaadet

Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

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Elif Nihal Korkmaz

Full Text Available The KIX domain of CBP is a transcriptional coactivator. Concomitant binding to the activation domain of proto-oncogene protein c-Myb and the transactivation domain of the trithorax group protein mixed lineage leukemia (MLL transcription factor lead to the biologically active ternary MLL∶KIX∶c-Myb complex which plays a role in Pol II-mediated transcription. The binding of the activation domain of MLL to KIX enhances c-Myb binding. Here we carried out molecular dynamics (MD simulations for the MLL∶KIX∶c-Myb ternary complex, its binary components and KIX with the goal of providing a mechanistic explanation for the experimental observations. The dynamic behavior revealed that the MLL binding site is allosterically coupled to the c-Myb binding site. MLL binding redistributes the conformational ensemble of KIX, leading to higher populations of states which favor c-Myb binding. The key element in the allosteric communication pathways is the KIX loop, which acts as a control mechanism to enhance subsequent binding events. We tested this conclusion by in silico mutations of loop residues in the KIX∶MLL complex and by comparing wild type and mutant dynamics through MD simulations. The loop assumed MLL binding conformation similar to that observed in the KIX∶c-Myb state which disfavors the allosteric network. The coupling with c-Myb binding site faded, abolishing the positive cooperativity observed in the presence of MLL. Our major conclusion is that by eliciting a loop-mediated allosteric switch between the different states following the binding events, transcriptional activation can be regulated. The KIX system presents an example how nature makes use of conformational control in higher level regulation of transcriptional activity and thus cellular events.

A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias.

NARCIS (Netherlands)

Bergh, A. von; Emanuel, B.; Zelderen-Bhola, S. van; Smetsers, A.F.C.M.; Soest, R. van; Stul, M.; Vranckx, H.; Schuuring, E.; Hagemeijer, A.; Kluin, P.

2000-01-01

Reciprocal translocations involving the MLL gene on chromosome band 11q23 have been observed in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). In AML, identification of MLL breakpoints is an important prognostic factor. Breakpoints are clustered in an 8 kb DNA fragment

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus.

Science.gov (United States)

Gyárfás, Tobias; Wintgens, Juergen; Biskup, Wolfgang; Oschlies, Ilske; Klapper, Wolfram; Siebert, Reiner; Bens, Susanne; Haferlach, Claudia; Meisel, Roland; Kuhlen, Michaela; Borkhardt, Arndt

2016-12-01

Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are common in neonatal AML. A female neonate born at 34 weeks gestation presented with cardiorespiratory failure, hepatosplenomegaly, pancytopenia, and coagulopathy. She required intensive care treatment including mechanical ventilation, high-dose catecholamine therapy, and multiple transfusions. Small intestinal biopsy obtained during laparotomy for meconium ileus revealed an infiltrate by an undifferentiated monoblastic, MLL-rearranged leukemia. No other manifestations of leukemia could be detected. After spontaneous clinical remission, lasting 5 months without any specific treatment, the patient presented with leukemia cutis and full-blown monoblastic leukemia. MLL-AF10-rearranged AML could be re-diagnosed and successfully treated with chemotherapy and hematopoietic stem cell transplantation. Our patient exhibited a unique manifestation of neonatal MLL-AF10 rearranged AML with cardiorespiratory failure and intestinal infiltration. It highlights the importance of leukemia in the differential diagnosis of neonatal distress, congenital hematological abnormalities, and skin lesions.

Favorable outcome in non-infant children with MLL-AF4-positive acute lymphoblastic leukemia: a report from the Tokyo Children's Cancer Study Group.

Science.gov (United States)

Tomizawa, Daisuke; Kato, Motohiro; Takahashi, Hiroyuki; Fujimura, Junya; Inukai, Takeshi; Fukushima, Takashi; Kiyokawa, Nobutaka; Koh, Katsuyoshi; Manabe, Atsushi; Ohara, Akira

2015-11-01

Unlike acute lymphoblastic leukemia (ALL) in infants, MLL gene rearrangement (MLL-r) is rare in ALL children (≥1 year old). The outcome and optimal treatment options for MLL-r ALL remain controversial. Among the 1827 children enrolled in the Tokyo Children's Cancer Study Group ALL studies L95-14, L99-15, L99-1502, L04-16, and L07-1602 (1995-2009), 25 MLL-r ALL patients (1.3 %) were identified. Their median age and leukocyte count at diagnosis was 2 years old (range 1-15 years) and 27,690/μL (range 1800-1,113,000/μL), respectively. All but one patient achieved complete remission (CR) after induction therapy, and 19 underwent allogeneic hematopoietic stem cell transplantation (HSCT) in first CR according to the protocol. The 5-year event-free survival (EFS) and overall survival (OS) rate were 60.0 % [standard error (SE), 9.7 %] and 64.0 % (SE 9.6 %), respectively. Notably, 9/12 cases with MLL-AF4-positive ALL are alive in continuous CR with a 75.0 % (SE 12.5 %) EFS rate. The causes of treatment failure were as follows: one induction failure, five relapses, and five transplant-related deaths. With intensive chemotherapy and allogeneic HSCT, favorable outcome of children (≥1 year old) with MLL-AF4-positive ALL was observed. However, considering the risk of acute and late toxicities associated with HSCT, its indication should be restricted.

Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

International Nuclear Information System (INIS)

Sakamoto, K; Imamura, T; Yano, M; Yoshida, H; Fujiki, A; Hirashima, Y; Hosoi, H

2014-01-01

All-trans retinoic acid (ATRA) is well established as differentiation therapy for acute promyelocytic leukemia (APL) in which the PML–RARα (promyelocytic leukemia-retinoic acid receptor α) fusion protein causes blockade of the retinoic acid (RA) pathway; however, in types of acute myeloid leukemia (AML) other than APL, the mechanism of RA pathway inactivation is not fully understood. This study revealed the potential mechanism of high ATRA sensitivity of mixed-lineage leukemia (MLL)-AF9-positive AML compared with MLL-AF4/5q31-positive AML. Treatment with ATRA induced significant myeloid differentiation accompanied by upregulation of RARα, C/EBPα, C/EBPε and PU.1 in MLL-AF9-positive but not in MLL-AF4/5q31-positive cells. Combining ATRA with cytarabine had a synergistic antileukemic effect in MLL-AF9-positive cells in vitro. The level of dimethyl histone H3 lysine 4 (H3K4me2) in the RARα gene-promoter region, PU.1 upstream regulatory region (URE) and RUNX1+24/+25 intronic enhancer was higher in MLL-AF9-positive cells than in MLL-AF4-positive cells, and inhibiting lysine-specific demethylase 1, which acts as a histone demethylase inhibitor, reactivated ATRA sensitivity in MLL-AF4-positive cells. These findings suggest that the level of H3K4me2 in the RARα gene-promoter region, PU.1 URE and RUNX1 intronic enhancer is determined by the MLL-fusion partner. Our findings provide insight into the mechanisms of ATRA sensitivity in AML and novel treatment strategies for ATRA-resistant AML

DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

Science.gov (United States)

Klaus, Christine R; Iwanowicz, Dorothy; Johnston, Danielle; Campbell, Carly A; Smith, Jesse J; Moyer, Mikel P; Copeland, Robert A; Olhava, Edward J; Scott, Margaret Porter; Pollock, Roy M; Daigle, Scott R; Raimondi, Alejandra

2014-09-01

EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol], a small-molecule inhibitor of the protein methyltransferase DOT1L, is currently under clinical investigation for acute leukemias bearing MLL-rearrangements (MLL-r). In this study, we evaluated EPZ-5676 in combination with standard of care (SOC) agents for acute leukemias as well as other chromatin-modifying drugs in cellular assays with three human acute leukemia cell lines: MOLM-13 (MLL-AF9), MV4-11 (MLL-AF4), and SKM-1 (non-MLL-r). Studies were performed to evaluate the antiproliferative effects of EPZ-5676 combinations in a cotreatment model in which the second agent was added simultaneously with EPZ-5676 at the beginning of the assay, or in a pretreatment model in which cells were incubated for several days in the presence of EPZ-5676 prior to the addition of the second agent. EPZ-5676 was found to act synergistically with the acute myeloid leukemia (AML) SOC agents cytarabine or daunorubicin in MOLM-13 and MV4-11 MLL-r cell lines. EPZ-5676 is selective for MLL-r cell lines as demonstrated by its lack of effect either alone or in combination in the nonrearranged SKM-1 cell line. In MLL-r cells, the combination benefit was observed even when EPZ-5676 was washed out prior to the addition of the chemotherapeutic agents, suggesting that EPZ-5676 sets up a durable, altered chromatin state that enhances the chemotherapeutic effects. Our evaluation of EPZ-5676 in conjunction with other chromatin-modifying drugs also revealed a consistent combination benefit, including synergy with DNA hypomethylating agents. These results indicate that EPZ-5676 is highly efficacious as a single agent and synergistically acts with other chemotherapeutics, including AML SOC drugs and DNA hypomethylating agents in MLL-r cells. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

Science.gov (United States)

Garrison, Brian S; Rybak, Adrian P; Beerman, Isabel; Heesters, Balthasar; Mercier, Francois E; Scadden, David T; Bryder, David; Baron, Roland; Rossi, Derrick J

2017-08-03

The concept that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as a means of enforcing their unlimited proliferative potential is widely accepted, yet identification of specific factors that regulate self-renewal of normal and cancer stem cells remains limited. Using a comparative transcriptomic approach, we identify ZNF521 / Zfp521 as a conserved hematopoietic stem cell (HSC)-enriched transcription factor in human and murine hematopoiesis whose function in HSC biology remains elusive. Competitive serial transplantation assays using Zfp521 -deficient mice revealed that ZFP521 regulates HSC self-renewal and differentiation. In contrast, ectopic expression of ZFP521 in HSCs led to a robust maintenance of progenitor activity in vitro. Transcriptional analysis of human acute myeloid leukemia (AML) patient samples revealed that ZNF521 is highly and specifically upregulated in AMLs with MLL translocations. Using an MLL-AF9 murine leukemia model and serial transplantation studies, we show that ZFP521 is not required for leukemogenesis, although its absence leads to a significant delay in leukemia onset. Furthermore, knockdown of ZNF521 reduced proliferation in human leukemia cell lines possessing MLL-AF9 translocations. Taken together, these results identify ZNF521/ZFP521 as a critical regulator of HSC function, which facilitates MLL-AF9-mediated leukemic disease in mice.

Kuidas ühiskondlikus leppes lubatud hea tuntavaks tehakse? / Jaak Aaviksoo, Jüri Tamm, Kaul Nurm...[jt.

Index Scriptorium Estoniae

2003-01-01

Küsimusele "missugune oleks nende panus ja plaan esimese aasta jooksul ühiskondlikus leppes fikseeritud eesmärkide saavutamiseks" vastavad Tartu Ülikooli rektor Jaak Aaviksoo, EOK asepresident Jüri Tamm, Eestimaa Talupidajate Keskliidu peadirektor Kaul Nurm, Eesti Kirikute Nõukogu täitevsekretär Eerik Jõks, Eesti Ühistegelise Liidu juhatuse esimees Urmas Laht, Eesti Väike- ja Keskettevõtjate Assotsiatsiooni juhataja Riina Danilson ning Reformierakonna pressinõunik Peep Lillemägi. Samas ka karikatuur

Archaeological excavations on the iron-smelting site in Tõdva village / Mauri Kiudsoo, Jaak Mäll, Irita Kallis

Index Scriptorium Estoniae

Kiudsoo, Mauri, 1973-

2009-01-01

Tõdva rauasulatuskompleksi puhul on tegemist esimese uuritud viikingiaegse rauasulatusakohaga Eestis. Uudseks võib pidada šlakianalüüsidel baseeruvat avastust, et tõenäoliselt tunti peale soomaagi ka meretekkelisi raua-mangaanikonkretsioone

Lõuna 2a villa restaureerimine Pärnus = Restoration of Lõuna 2a villa in Pärnu / Jaak Huimerind, Mari Kurismaa, Mart Kalm ; kommenteerinud Liina Jänes

Index Scriptorium Estoniae

Huimerind, Jaak, 1957-

2015-01-01

Villa Pärnus Lõuna tänav 2a, valminud 1936, restaureeritud 2014. Hoone arhitektid Olev Siinmaa, Anton Soans, restaureerimisarhitekt Jaak Huimerind, sisearhitekt Mari Kurismaa. Eesti Kultuurkapitali Arhitektuuri sihtkapitali restaureerimispreemia 2014

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Energy Technology Data Exchange (ETDEWEB)

Karatas, Hacer; Li, Yangbing; Liu, Liu; Ji, Jiao; Lee, Shirley; Chen, Yong; Yang, Jiuling; Huang, Liyue; Bernard, Denzil; Xu, Jing; Townsend, Elizabeth C.; Cao, Fang; Ran, Xu; Li, Xiaoqin; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A; Lei, Ming; Dou, Yali; Wang, Shaomeng (Michigan)

2017-06-06

We report herein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domain 5 (WDR5) and block the WDR5–mixed lineage leukemia (MLL) protein–protein interaction. Compound 18 (MM-589) binds to WDR5 with an IC50 value of 0.90 nM (Ki value <1 nM) and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 value of 12.7 nM. Compound 18 potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations and is >40 times better than the previously reported compound MM-401. Cocrystal structures of 16 and 18 complexed with WDR5 provide structural basis for their high affinity binding to WDR5. Additionally, we have developed and optimized a new AlphaLISA-based MLL HMT functional assay to facilitate the functional evaluation of these designed compounds. Compound 18 represents the most potent inhibitor of the WDR5–MLL interaction reported to date, and further optimization of 18 may yield a new therapy for acute leukemia.

Crystal Structure of Human Taspase1, a Crucial Protease Regulating the Function of MLL

Energy Technology Data Exchange (ETDEWEB)

Khan,J.; Dunn, B.; Tong, L.

2005-01-01

Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for maintaining Hox gene expression patterns. Chromosomal translocations of the MLL gene are associated with leukemia in infants. Taspase1, a threonine aspartase, is a member of the type 2 asparaginase family, but is the only protease in this family. We report here the crystal structures of human activated Taspase1 and its proenzyme, as well as the characterization of the effects of mutations in the active site region using a newly developed fluorogenic assay. The structure of Taspase1 has significant differences from other asparaginases, especially near the active site. Mutation of the catalytic nucleophile, Thr234, abolishes autocatalytic processing in cis but does not completely block proteolysis in trans. The structure unexpectedly showed the binding of a chloride ion in the active site, and our kinetic studies confirm that chlorides ions are inhibitors of this enzyme at physiologically relevant concentrations.

MLL-AF4 fusion transcripts in Acute Lymphocytic Leukemia patientsin Children hospital of Tabriz

Directory of Open Access Journals (Sweden)

Amir Monfaredan

2014-08-01

Full Text Available Background: MLL-AF4 positive Leukemias comprise about 50-70% of acute lymphoid leukemias in children and about 5% of adolescents and adults Despite recent advances in the treatment of hematologic malignancies of children with ALL in particular, but it seems that poor results are obtained from treating this type of malignancy. Perhaps it is due to the lack of enough knowledge about the expression pattern of the fusion gene induced by chromosomal translocations. This study aims to consider several aspects of the common chromosomal disorder, t (4 11: due to lack of accurate statistical results for this type of translocation in our country, acceptable results are provided Sprevalence of isoforms of recombinant genes involved in MLL-AF4 are explained. Materials and methods: Of 36 patients with ALL between 4 months -11 years of age, peripheral blood sampling was done and total RNA extracted and cDNA was made. Then cDNA was amplified in two steps with the PCR and Nested PCR reactions. After electrophoresis the products were compared and analyzed in comparison with the internal control. Results: The results showed that MLL-AF4 recombinant gene expression in the age between 4 to 12 months range is maximum in the second stage by Nested PCR. Also the highest frequency of fusion isoforms of the gene involved in the same age range is e11-e4 isoform with the frequency of 0.13. Conclusion: It seems that investigation of translocation and chromosomal abnormalities using molecular techniques is one of the most accurate and suitable methods for identifying chromosomal characteristics in patients with acute leukemia, particularly ALL.

Morus alba Leaf Lectin (MLL) Sensitizes MCF-7 Cells to Anoikis by Inhibiting Fibronectin Mediated Integrin-FAK Signaling through Ras and Activation of P38 MAPK

Science.gov (United States)

Saranya, Jayaram; Shilpa, Ganesan; Raghu, Kozhiparambil G.; Priya, Sulochana

2017-01-01

Lectins are a unique class of carbohydrate binding proteins/glycoproteins, and many of them possess anticancer properties. They can induce cell cycle arrest and apoptosis, inhibit protein synthesis, telomerase activity and angiogenesis in cancer cells. In the present study, we have demonstrated the effect of Morus alba leaf lectin (MLL) on anoikis induction in MCF-7 cells. Anoikis induction in cancer cells has a significant role in preventing early stage metastasis. MLL treatment in monolayers of MCF-7 cells caused significant detachment of cells in a time and concentration dependent manner. The detached cells failed to re-adhere and grew even to culture plates coated with different matrix proteins. DNA fragmentation, membrane integrity studies, annexin V staining, caspase 9 activation and upregulation of Bax/Bad confirmed that the detached cells underwent apoptosis. Upregulation of matrix metalloproteinase 9 (MMP-9) caused a decrease in fibronectin (FN) production which facilitated the cells to detach by blocking the FN mediated downstream signaling. On treatment with MLL, we have observed downregulation of integrin expression, decreased phosphorylation of focal adhesion kinase (FAK), loss in FAK-integrin interaction and active Ras. MLL treatment downregulated the levels of phosphorylated Akt and PI3K. Also, we have studied the effect of MLL on two stress activated protein kinases p38 MAPK and JNK. p38 MAPK activation was found to be elevated, but there was no change in the level of JNK. Thus our study substantiated the possible antimetastatic effect of MLL by inducing anoikis in MCF-7 cells by activation of caspase 9 and proapoptotic Bax/Bad by blockage of FN mediated integrin/FAK signaling and partly by activation of p38 MAPK. PMID:28223935

Eesti Ajaloomuuseumi, Maarjamäe lossi tallihoone renoveerimine = Renovation of the Estonian History Museum's Maarjamäe palace stables / Jaak Huimerind, Tarmo Piirmets ; kommenteerinud Kaido Kivi

Index Scriptorium Estoniae

Huimerind, Jaak, 1957-

2015-01-01

Eesti Ajaloomuuseumi Maarjamäe lossi renoveeritud tallihoone Tallinnas Pirita tee 66, valminud 2014. Arhitekt Jaak Huimerind (Studio Paralleel OÜ), sisearhitekt ja näituse kujundaja Tarmo Piirmets (Pink OÜ). Eesti Kultuurkapitali Arhitektuuri sihtkapitali renoveerimispreemia 2014

Mida arvate ideest, et kõrgkoole võiks juhtida ülikoolivälistest inimestest koosnev nõukogu? / Jaak Aaviksoo, Maris Mälzer, Peeter Kreitzberg, Peep Sürje

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastavad Tartu Ülikooli eelmine rektor Jaak Aaviksoo, Eesti Üliõpilaskondade Liidu esimees Maris Mälzer, Riigikogu kultuurikomisjoni esimees Peeter Kreitzberg ja Tallinna Tehnikaülikooli rektor Peep Sürje

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

Science.gov (United States)

Huang, Xu; Spencer, Gary J; Lynch, James T; Ciceri, Filippo; Somerville, Tim D D; Somervaille, Tim C P

2013-01-01

Through a targeted knockdown (KD) screen of chromatin regulatory genes we identified the EP400 complex components EPC1 and EPC2 as critical oncogenic co-factors in acute myeloid leukemia (AML). EPC1 and EPC2 were required for the clonogenic potential of human AML cells of multiple molecular subtypes. Focusing on MLL-mutated AML as an exemplar, Epc1 or Epc2 KD induced apoptosis of murine MLL-AF9 AML cells and abolished leukemia stem cell potential. By contrast, normal hematopoietic stem and progenitor cells (HSPC) were spared. Similar selectivity was observed for human primary AML cells versus normal CD34+ HSPC. In keeping with these distinct functional consequences, Epc1 or Epc2 KD induced divergent transcriptional consequences in murine MLL-AF9 granulocyte-macrophage progenitor-like (GMP) cells versus normal GMP, with a signature of increased MYC activity in leukemic but not normal cells. This was caused by accumulation of MYC protein and was also observed following KD of other EP400 complex genes. Pharmacological inhibition of MYC:MAX dimerization, or concomitant MYC KD, reduced apoptosis following EPC1 KD, linking the accumulation of MYC to cell death. Therefore EPC1 and EPC2 are components of a complex which directly or indirectly serves to prevent MYC accumulation and AML cell apoptosis, thus sustaining oncogenic potential. PMID:24166297

MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.

NARCIS (Netherlands)

Horton, S.J.; Jaques, J.; Woolthuis, C.; Dijk, J. van; Mesuraca, M.; Huls, G.A.; Morrone, G.; Vellenga, E.; Schuringa, J.J.

2013-01-01

The MLL-AF9 fusion gene is associated with aggressive leukemias of both the myeloid and lymphoid lineage in infants, whereas in adults, this translocation is mainly associated with acute myeloid leukemia. These observations suggest that differences exist between fetal and adult tissues in terms of

LEDGF/p75 as a target for treatment of MLL-dependent leukemia and HIV infection

Czech Academy of Sciences Publication Activity Database

Čermáková, K.; Těšina, Petr; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Christ, F.; Debyser, Z.; Řezáčová, Pavlína; Veverka, Václav; De Rijck, J.

2015-01-01

Roč. 22, č. 1 (2015), s. 30 ISSN 1211-5894. [Discussions in Structural Molecular Biology. Annual Meeting of the Czech Society for Structural Biology /13./. 19.03.2015-21.03.2015, Nové Hrady] Institutional support: RVO:61388963 Keywords : LEDGF/p75 * leukemia * MLL Subject RIV: CE - Biochemistry

Hamilton on surnud, tema mõju mitte : in memoriam Richard Hamilton (24. II 1922 - 13. IX 2011) / Kadri Karro ; kommenteerinud Eha Komissarov, Sirje Helme, Jaak Kangilaski

Index Scriptorium Estoniae

Karro,Kadri

2011-01-01

Briti kunstniku Richard Hamiltoni (1922 - 2011) loomingust eesti kunstiteadlaste Eha Komissarovi, Sirje Helme ja Jaak Kangilaski pilgu läbi. Lähemalt 1956. aastal valminud kollaažist "Mis teeb tänapäeva kodud nii eriliseks, nii meeldivaks?"

Morel-Lavallee Lesion (MLL) Mimicking A Soft Tissue Neoplasm.

Science.gov (United States)

Kumar, Sandeep; Hasan, Roumina; Kadavigere, Rajagopal; Maddukuri, Satish Babu; Puppala, Radha

2015-04-01

Morel-lavallee lesion (MLL) represents post traumatic subcutaneous cyst generally overlying bony prominences like greater trochanter, lower back, knee and scapula. A 51-year-old man presented with a swelling in left thigh since six years which was insidious in onset, gradually progressive in size and not associated with pain, fever or discharge. There was no history of trauma or any associated constitutional symptoms. Since there was no history of trauma recalled by the patient the clinical dilemma was between soft tissue sarcoma and cold abscess. We report a case of slow growing painless mass lesion of thigh, diagnosed on Magnetic Resonance Imaging (MRI) as morel lavallee lesion and describe its salient imaging features with treatment options.

Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

African Journals Online (AJOL)

Background: Variations in disease presentation and outcome of leukemia treatment has been associated with the presence of certain mutant genes. Three major translocations (ETV6‑RUNX1, BCR‑ABL, and AF4‑MLL) in acute lymphoblastic leukemia (ALL) have been shown to affect treatment outcome. This study is aimed ...

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

Directory of Open Access Journals (Sweden)

Alvaro Muñoz-López

2016-10-01

Full Text Available Induced pluripotent stem cells (iPSCs are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming leukemias is an extremely inefficient process. Few studies generated iPSCs from primary chronic myeloid leukemias, but iPSC generation from acute myeloid or lymphoid leukemias (ALL has not been achieved. We attempted to generate iPSCs from different subtypes of B-ALL to address the developmental impact of leukemic fusion genes. OKSM(L-expressing mono/polycistronic-, retroviral/lentiviral/episomal-, and Sendai virus vector-based reprogramming strategies failed to render iPSCs in vitro and in vivo. Addition of transcriptomic-epigenetic reprogramming “boosters” also failed to generate iPSCs from B cell blasts and B-ALL lines, and when iPSCs emerged they lacked leukemic fusion genes, demonstrating non-leukemic myeloid origin. Conversely, MLL-AF4-overexpressing hematopoietic stem cells/B progenitors were successfully reprogrammed, indicating that B cell origin and leukemic fusion gene were not reprogramming barriers. Global transcriptome/DNA methylome profiling suggested a developmental/differentiation refractoriness of MLL-rearranged B-ALL to reprogramming into pluripotency.

Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

African Journals Online (AJOL)

2015-05-12

May 12, 2015 ... features of prognostic importance, which include total white blood cell count (P = 0.416) and FAB subtype (P = 0.576). Conclusion: Presence of fusion ... Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR/ABL fusion ... define distinct clinic‑pathological subgroups and have been used in risk ...

Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expression.

Science.gov (United States)

Pascual-Garcia, Pau; Jeong, Jieun; Capelson, Maya

2014-10-23

The nuclear pore complex is a transport channel embedded in the nuclear envelope and made up of 30 different components termed nucleoporins (Nups). In addition to their classical role in transport, a subset of Nups has a conserved role in the regulation of transcription via direct binding to chromatin. The molecular details of this function remain obscure, and it is unknown how metazoan Nups are recruited to their chromatin locations or what transcription steps they regulate. Here, we demonstrate genome-wide and physical association between Nup98 and histone-modifying complexes MBD-R2/NSL [corrected] and Trx/MLL. Importantly, we identify a requirement for MBD-R2 in recruitment of Nup98 to many of its genomic target sites. Consistent with its interaction with the Trx/MLL complex, Nup98 is shown to be necessary for Hox gene expression in developing fly tissues. These findings introduce roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of Nup98 fusions in leukemia.

Theory of drives and emotions - from Sigmund Freud to Jaak Panksepp.

Science.gov (United States)

Żechowski, Cezary

2017-12-30

The article discusses the development of psychoanalytic theory in the direction of broadening the reflection on their own based on data derived from empirical studies other than clinical case study. Particularly noteworthy is the convergence that followed between neuroscience and psychoanalysis and the rise of the so-called neuropsychoanalysis. Consequently, this led to eject empirical hypotheses and begin research on defense mechanisms, self, memory, dreams, empathy, dynamic unconscious and emotional-motivational processes (theory of drives). Currently neuropsychoanalysis constituted itself as a discipline contained in itself three separate areas: the psychodynamic neuroscience, clinical neuropsychoanalysis and theory building. The article introduces the theory of Jaak Panksepp emotional systems as an example of anintegrated neurobiology of affect, behavioral biology, evolutionary psychology and psychoanalysis. The theory of emotional systems includes the description of the SEEKING system representing basic motivational system of the organism. Apart from a new perspective on the theory of drives described by Sigmund Freud, it offers the possibility to take into account the emotional and motivational systems within the understanding of mental disorders such as depression, addiction and psychosis, which is the core of psychoanalytic thinking.

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

Science.gov (United States)

Cruickshank, M N; Ford, J; Cheung, L C; Heng, J; Singh, S; Wells, J; Failes, T W; Arndt, G M; Smithers, N; Prinjha, R K; Anderson, D; Carter, K W; Gout, A M; Lassmann, T; O'Reilly, J; Cole, C H; Kotecha, R S; Kees, U R

2017-01-01

To address the poor prognosis of mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia (iALL), we generated a panel of cell lines from primary patient samples and investigated cytotoxic responses to contemporary and novel Food and Drug Administration-approved chemotherapeutics. To characterize representation of primary disease within cell lines, molecular features were compared using RNA-sequencing and cytogenetics. High-throughput screening revealed variable efficacy of currently used drugs, however identified consistent efficacy of three novel drug classes: proteasome inhibitors, histone deacetylase inhibitors and cyclin-dependent kinase inhibitors. Gene expression of drug targets was highly reproducible comparing iALL cell lines to matched primary specimens. Histone deacetylase inhibitors, including romidepsin (ROM), enhanced the activity of a key component of iALL therapy, cytarabine (ARAC) in vitro and combined administration of ROM and ARAC to xenografted mice further reduced leukemia burden. Molecular studies showed that ROM reduces expression of cytidine deaminase, an enzyme involved in ARAC deactivation, and enhances the DNA damage–response to ARAC. In conclusion, we present a valuable resource for drug discovery, including the first systematic analysis of transcriptome reproducibility in vitro, and have identified ROM as a promising therapeutic for MLL-rearranged iALL. PMID:27443263

Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11(q21;q23/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia

Directory of Open Access Journals (Sweden)

F. Marchesi

2011-01-01

Full Text Available Translocation t(4;11(q21;q23 leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL in adult patients. Patients expressing this chromosomal aberration present typical biological, immunophenotypic, and clinical features. This form of leukemia is universally recognized as high-risk leukemia and treatment intensification with allogeneic hematopoietic stem cell transplantation (HSCT in first complete remission (CR could be a valid option to improve prognosis, but data obtained from the literature are controversial. In this review, we briefly describe pathogenetic, clinical, and prognostic characteristics of adult t(4;11(q21;q23/MLL-AF4 positive ALL and provide a review of the clinical outcome reported by the most important cooperative groups worldwide.

Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.

Science.gov (United States)

Dai, Qian; Shen, Yang; Wang, Yan; Wang, Xin; Francisco, Joel Celio; Luo, Zhuojuan; Lin, Chengqi

2017-12-01

Transposable elements (TEs) compose about 40% of the murine genome. Retrotransposition of active TEs such as LINE-1 (L1) tremendously impacts genetic diversification and genome stability. Therefore, transcription and transposition activities of retrotransposons are tightly controlled. Here, we show that the Krüppel-like zinc finger protein Zfp281 directly binds and suppresses a subset of retrotransposons, including the active young L1 repeat elements, in mouse embryonic stem (ES) cells. In addition, we find that Zfp281-regulated L1s are highly enriched for 5-hydroxymethylcytosine (5hmC) and H3K4me3. The COMPASS-like H3K4 methyltransferase Mll2 is the major H3K4me3 methylase at the Zfp281-regulated L1s and required for their proper expression. Our studies also reveal that Zfp281 functions partially through recruiting the L1 regulators DNA hydroxymethylase Tet1 and Sin3A, and restricting Mll2 at these active L1s, leading to their balanced expression. In summary, our data indicate an instrumental role of Zfp281 in suppressing the young active L1s in mouse ES cells. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

Science.gov (United States)

Gardner, Rebecca; Wu, David; Cherian, Sindhu; Fang, Min; Hanafi, Laïla-Aïcha; Finney, Olivia; Smithers, Hannah; Jensen, Michael C; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J

2016-05-19

Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. All patients achieved complete remission (CR) in the bone marrow by flow cytometry after CD19 CAR-T-cell therapy; however, within 1 month of CAR-T-cell infusion, 2 of the patients developed acute myeloid leukemia (AML) that was clonally related to their B-ALL, a novel mechanism of CD19-negative immune escape. These reports have implications for the management of patients with relapsed and refractory MLL-B-ALL who receive CD19 CAR-T-cell therapy. © 2016 by The American Society of Hematology.

GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.

Science.gov (United States)

Dietrich, Philipp A; Yang, Chen; Leung, Halina H L; Lynch, Jennifer R; Gonzales, Estrella; Liu, Bing; Haber, Michelle; Norris, Murray D; Wang, Jianlong; Wang, Jenny Yingzi

2014-11-20

β-catenin is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML). Targeted inhibition of β-catenin signaling has been hampered by the lack of pathway components amenable to pharmacologic manipulation. Here we identified a novel β-catenin regulator, GPR84, a member of the G protein-coupled receptor family that represents a highly tractable class of drug targets. High GPR84 expression levels were confirmed in human and mouse AML LSCs compared with hematopoietic stem cells (HSCs). Suppression of GPR84 significantly inhibited cell growth by inducing G1-phase cell-cycle arrest in pre-LSCs, reduced LSC frequency, and impaired reconstitution of stem cell-derived mixed-lineage leukemia (MLL) AML, which represents an aggressive and drug-resistant subtype of AML. The GPR84-deficient phenotype in established AML could be rescued by expression of constitutively active β-catenin. Furthermore, GPR84 conferred a growth advantage to Hoxa9/Meis1a-transduced stem cells. Microarray analysis demonstrated that GPR84 significantly upregulated a small set of MLL-fusion targets and β-catenin coeffectors, and downregulated a hematopoietic cell-cycle inhibitor. Altogether, our data reveal a previously unrecognized role of GPR84 in maintaining fully developed AML by sustaining aberrant β-catenin signaling in LSCs, and suggest that targeting the oncogenic GPR84/β-catenin signaling axis may represent a novel therapeutic strategy for AML. © 2014 by The American Society of Hematology.

FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.

Science.gov (United States)

Nasilowska-Adamska, Barbara; Solarska, Iwona; Paluszewska, Monika; Malinowska, Iwona; Jedrzejczak, Wieslaw W; Warzocha, Krzysztof

2014-04-01

Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and mixed-lineage leukemia gene-partial tandem duplication (MLL-PTD) are aberrations associated with leukemia which indicate unsatisfactory prognosis. Downstream regulatory targets of FLT3-ITD and MLL-PTD are not well defined. We have analyzed the expression of MDR-1, multidrug resistant protein-1 (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) messenger RNA (mRNA) in relation to the mutational status of FLT3-ITD and MLL-PTD in 185 acute myeloid leukemia (AML) adult patients. The real-time quantitative polymerase chain reaction method was performed to assess the expression of the MDR-1, MRP-1, BCRP, and LRP mRNA, and the results were presented as coefficients calculated using an intermediate method according to Pfaffl's rule. Significantly higher expressions of MDR-1 mRNA were found in patients who did not harbor FLT3-ITD (0.20 vs. 0.05; p = 0.0001) and MRP-1 mRNA in patients with this mutation (0.96 vs. 0.70; p = 0.002) and of BCRP mRNA in patients with MLL-PTD (0.61 vs. 0.38; p = 0.03). In univariate analysis, the high expression of MDR-1 mRNA (≥0.1317) negatively influenced the outcome of induction therapy (p = 0.05), whereas the high expression of BCRP mRNA (≥1.1487) was associated with a high relapse rate (RR) (p = 0.013). We found that the high expression of MDR-1 (≥0.1317), MRP-1 (≥0.8409), and BCRP mRNA (≥1.1487) significantly influenced disease-free survival (DFS; p = 0.059, 0.032, and 0.009, respectively) and overall survival (0.048, 0.014, and 0.059, respectively). Moreover, a high expression of BCRP mRNA (≥1.1487) proved to be an independent prognostic factor for RR (p = 0.01) and DFS (p = 0.002) in multivariate analysis. The significant correlation between the expression of MDR-1, MRP-1, and BCRP mRNA and FLT3-ITD or MLL-PTD in AML patients requires further investigation.

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia

Directory of Open Access Journals (Sweden)

Hoeksema KA

2011-09-01

Full Text Available Kimberley A Hoeksema1, Aarthi Jayanthan1, Todd Cooper2, Lia Gore3, Tanya Trippett4, Jessica Boklan6, Robert J Arceci5, Aru Narendran11Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, AB, Canada; 2Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA; 3Center for Cancer and Blood Disorders, Children's Hospital, University of Colorado Denver, Aurora, CO, USA; 4Memorial Sloan-Kettering Cancer Center, New York, NY, USA; 5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA; 6Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USAAbstract: Despite significant progress made in the overall cure rate, the prognosis for relapsed and refractory malignancies in children remains extremely poor. Hence, there is an urgent need for studies that enable the timely selection of appropriate agents for Phase I clinical studies. The Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC is systematically evaluating libraries of known and novel compounds for activity against subsets of high-risk pediatric malignancies with defined molecular aberrations for future clinical development. In this report, we describe the in-vitro activity of a diverse panel of approved oncology drugs against MLL-rearranged pediatric leukemia cell lines. Agents in the Approved Oncology Drug Set II (National Cancer Institute/National Institutes of Health Developmental Therapeutics Program were evaluated by in-vitro cytotoxicity assays in pediatric acute lymphoblastic leukemia and acute myeloid leukemia cell lines with MLL gene rearrangements. Validation studies were carried out with patient leukemia cells in culture. Comparative analysis for toxicity against nonmalignant cells was evaluated in normal bone marrow stromal cells and normal human lymphocytes. Results from this study show that 42 of the 89 agents tested have

Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study

DEFF Research Database (Denmark)

Mann, Georg; Attarbaschi, Andishe; Schrappe, Martin

2010-01-01

received chemotherapy only (P = .03). However, the advantage was restricted to a subgroup with 2 additional unfavorable prognostic features: age less than 6 months and either poor response to steroids at day 8 or leukocytes more than or equal to 300 g/L. Ninety-seven of 297 MLL(+) patients (33%) had...

Determination of the extraction efficiency for {sup 233}U source α-recoil ions from the MLL buffer-gas stopping cell

Energy Technology Data Exchange (ETDEWEB)

Wense, Lars v.d.; Seiferle, Benedict; Thirolf, Peter G. [Ludwig-Maximilians-Universitaet Muenchen, Garching (Germany); Laatiaoui, Mustapha [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Helmholtz Institut Mainz, Mainz (Germany)

2015-03-01

Following the α decay of {sup 233}U, {sup 229}Th recoil ions are shown to be extracted in a significant amount from the MLL buffer-gas stopping cell. The produced recoil ions and subsequent daughter nuclei are mass purified with the help of a customized quadrupole mass spectrometer. The combined extraction and mass purification efficiency for {sup 229}Th{sup 3+} is determined via MCP-based measurements and via the direct detection of the {sup 229}Th α decay. A large value of (10±2)% for the combined extraction and mass purification efficiency of {sup 229}Th{sup 3+} is obtained at a mass resolution of about 1u/e. In addition to {sup 229}Th, also other α-recoil ions of the {sup 233,} {sup 232}U decay chains are addressed. (orig.)

Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.

Science.gov (United States)

Koues, Olivia I; Mehta, Ninad T; Truax, Agnieszka D; Dudley, R Kyle; Brooks, Jeanne K; Greer, Susanna F

2010-02-04

Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription. Our previous studies indicate that H3 lysine 4 trimethylation at cytokine-inducible MHC-II and CIITA promoters is dependent on proteolytic-independent functions of 19S ATPases. In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters. In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1. Taken together, these experiments suggest that the 19S proteasome plays a crucial role in the initial reorganization of events enabling the relaxation of the repressive chromatin structure surrounding inducible promoters.

Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation

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Koues Olivia I

2010-02-01

Full Text Available Abstract Background Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC-II and class II transactivator (CIITA promoters, implicating Sug1 in events required to initiate mammalian transcription. Results Our previous studies indicate that H3 lysine 4 trimethylation at cytokine-inducible MHC-II and CIITA promoters is dependent on proteolytic-independent functions of 19S ATPases. In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL/complex of proteins associated with Set I (COMPASS complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters. In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1. Conclusion Taken together, these experiments suggest that the 19S proteasome plays a crucial role in the initial reorganization of events enabling the relaxation of the repressive chromatin structure surrounding inducible promoters.

Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia.

Science.gov (United States)

Wang, Rong; Feng, Wenli; Yang, Feifei; Yang, Xiao; Wang, Lina; Chen, Chong; Hu, Yuting; Ren, Qian; Zheng, Guoguang

2018-02-01

Macrophage colony-stimulating factor (M-CSF) regulates both malignant cells and microenvironmental cells. Its splicing isoforms show functional heterogeneity. However, their roles on leukemia have not been well established. Here, the expression of total M-CSF in patients with hematopoietic malignancies was analyzed. The roles of M-CSF isoforms on the progression of acute myeloid leukemia (AML) were studied by establishing MLL-AF9-induced mouse AML models with high level membrane-bound M-CSF (mM-CSF) or soluble M-CSF (sM-CSF). Total M-CSF was highly expressed in myeloid leukemia patients. Furthermore, mM-CSF but not sM-CSF prolonged the survival of leukemia mice. While sM-CSF was more potent to promote proliferation and self-renew, mM-CSF was more potent to promote differentiation. Moreover, isoforms had different effects on leukemia-associated macrophages (LAMs) though they both increase monocytes/macrophages by growth-promoting and recruitment effects. In addition, mM-CSF promoted specific phagocytosis of leukemia cells by LAMs. RNA-seq analysis revealed that mM-CSF enhanced phagocytosis-associated genes and activated oxidative phosphorylation and metabolism pathway. These results highlight heterogeneous effects of M-CSF isoforms on AML progression and the mechanisms of mM-CSF, that is, intrinsically promoting AML cell differentiation and extrinsically enhancing infiltration of macrophages and phagocytosis by macrophages, which may provide potential clues for clinical diagnosis and therapy. © 2017 Australasian Society for Immunology Inc.

Testing the potential significance of different scion/rootstock genotype combinations on the ecology of old cultivated olive trees in the southeast Mediterranean area.

Science.gov (United States)

Barazani, Oz; Waitz, Yoni; Tugendhaft, Yizhar; Dorman, Michael; Dag, Arnon; Hamidat, Mohammed; Hijawi, Thameen; Kerem, Zohar; Westberg, Erik; Kadereit, Joachim W

2017-02-06

A previous multi-locus lineage (MLL) analysis of SSR-microsatellite data of old olive trees in the southeast Mediterranean area had shown the predominance of the Souri cultivar (MLL1) among grafted trees. The MLL analysis had also identified an MLL (MLL7) that was more common among rootstocks than other MLLs. We here present a comparison of the MLL combinations MLL1 (scion)/MLL7 (rootstock) and MLL1/MLL1 in order to investigate the possible influence of rootstock on scion phenotype. A linear regression analysis demonstrated that the abundance of MLL1/MLL7 trees decreases and of MLL1/MLL1 trees increases along a gradient of increasing aridity. Hypothesizing that grafting on MLL7 provides an advantage under certain conditions, Akaike information criterion (AIC) model selection procedure was used to assess the influence of different environmental conditions on phenotypic characteristics of the fruits and oil of the two MLL combinations. The most parsimonious models indicated differential influences of environmental conditions on parameters of olive oil quality in trees belonging to the MLL1/MLL7 and MLL1/MLL1 combinations, but a similar influence on fruit characteristics and oil content. These results suggest that in certain environments grafting of the local Souri cultivar on MLL7 rootstocks and the MLL1/MLL1 combination result in improved oil quality. The decreasing number of MLL1/MLL7 trees along an aridity gradient suggests that use of this genotype combination in arid sites was not favoured because of sensitivity of MLL7 to drought. Our results thus suggest that MLL1/MLL7 and MLL1/MLL1 combinations were selected by growers in traditional rain-fed cultivation under Mediterranean climate conditions in the southeast Mediterranean area.

ROLi juhatuses on ees ootamas suured muudatused / Matis Song

Index Scriptorium Estoniae

Song, Matis, 1978-

2004-01-01

Raplamaa Omavalitsuste Liidu täiskogul arutluse all olnud olulisematest probleemidest. Vallavanemate kogu esimees, Raikküla vallavanem Jaak Pregel ning ROL-i tegevdirektor Jaak Herodes kavatsevad ametist lahkuda

Pust budet bezoblatshnõm nebo nad Baltiiskim domom / Ella Agranovskaja

Index Scriptorium Estoniae

Agranovskaja, Ella, 1950-

2000-01-01

Teatrifestivali "Baltiiski dom" nimelise medali "Stroitel Baltiiskogo doma" pälvisid teatrikriitik Eteri Kekelidze, lavastaja Elmo Nüganen, endine kultuuriminister Jaak Allik, Vene Draamateatri direktor Aleksandr Iljin, teatrijuht Jaak Viller ja Kultuuriministeeriumi kantsler Margus Allikmaa

Rector's office as of 31 December 2005

Index Scriptorium Estoniae

2006-01-01

TÜ rektoraadi koosseis: rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Tõnu Lehtsaar, prorektor prof. Jaak Kangilaski; administratsioonidirektor Mihkel Pärnoja, finantsdirektor Taimo Saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

Rektoraat seisuga 31.12. 2005

Index Scriptorium Estoniae

2006-01-01

TÜ rektoraadi koosseis: rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Tõnu Lehtsaar, prorektor prof. Jaak Kangilaski; administratsioonidirektor Mihkel Pärnoja, finantsdirektor Taimo Saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

Sepistada oma rahvale süüme / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

2003-01-01

Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003

Rõõm Joyce'i raamatuist / Toomas Raudam

Index Scriptorium Estoniae

Raudam, Toomas, 1947-

2003-01-01

Arvustus: Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003 ; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003

Cannes südames / Mirkka Maikola

Index Scriptorium Estoniae

Maikola, Mirkka

2011-01-01

Nicolas Winding Refni filmist "Drive" (USA 2011). Lisaks tegid oma pingerea Cannes´is nähtud filmidest Eesti filmikriitikud ja -tegijad Jaan Ruus, Jaak Lõhmus, Tristan Priimägi, Jaak Kilmi, Andris Feldmanis, Maria Ulfsak-Šeripova ja Laura Talvet

Journey towards yourself / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2011-01-01

Arvustus: Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010 ; Luik, Viivi, Rosma, Hedi. Ma olen raamat. Tallinn : SE & JS, 2010 ; Jõerüüt, Jaak. Armastuse laiad, kõrged hooned. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010

Kaberla kalmistu 12.-13. sajandi klaashelmed / Irita Kallis

Index Scriptorium Estoniae

Kallis, Irita

2010-01-01

Kaberla kalmistult leitud klaashelmestest, põhitähelepanu on 12.-13. saj. matuste inventari hulka kuulunud leiumaterjalil. Ülevaade helmeste esimemisvariatsioonidest helmekeedes, võimalikust tähendusest ja väärtusest ning samatüübiliste helmeste dateeringutest naaberaladel

Betti Alveri sünniaastapäeval kuulutatakse välja järjekordne Alveri kirjandusauhinna saaja...

Index Scriptorium Estoniae

2005-01-01

Kirjandusauhinna nominendid: Sass Henno. Mina olin siin ; Andrei Hvostov. Lombakas Achilleus ; Mart Kangur, Jaak Rand ja Ivar Ravi. Jaak Rand ja teisi jutte ; Diana Leesalu. 2 grammi hämaruseni ; Jaan Pehk. Sisukord ; Linnar Priimägi. Kelle tee on varjul ; Leo de Sixtus. Skarabeuse tsivilisatsioon

Teadlase eetika / Magnus Ilmjärv

Index Scriptorium Estoniae

Ilmjärv, Magnus, 1961-

2008-01-01

Vastukaja art.: Valge, Jaak. Pätsi riigipööret ei inspireeritud väljastpoolt // Postimees (2008) 26. apr., lk. 13. President Konstantin Pätsi kohta leitud uutest arhiivimaterjalidest. Raamatu "Hääletu alistumine" autor, ajaloolane Magnus Ilmjärv peab Jaak Valge kriitikat tema suhtes põhjendamatult suureks

James Joyce kui religiooni subjekt ja objekt / Kalle Käsper

Index Scriptorium Estoniae

Käsper, Kalle, 1952-

2003-01-01

Arvustus: Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003 ; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003; vt ka vastukaja: Raudam, Toomas. Kontra Käsper // Sirp (2003) 20. juuni, lk. 5

Selgusid Betti Alveri preemia nominendid

Index Scriptorium Estoniae

2005-01-01

Betti Alveri kirjandusauhinna nominendid: Sass Henno "Mina olin siin", Andrei Hvostovi "Lombakas Achilleus", Mart Kanguri, Jaak Ranna ja Ivar Ravi "Jaak Rand ja teisi jutte", Diana Leesalu "2 grammi hämaruseni", Jaan Pehki "Sisukord", Linnar Priimäe "Kelle tee on varjul", Leo de Sixtuse "Skarabeuse tsivilisatsioon". Vt. ka Eesti Päevaleht, 16. nov., lk. 15

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.

Science.gov (United States)

Lu, Chunwan; Paschall, Amy V; Shi, Huidong; Savage, Natasha; Waller, Jennifer L; Sabbatini, Maria E; Oberlies, Nicholas H; Pearce, Cedric; Liu, Kebin

2017-01-01

Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1 immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to checkpoint immunotherapy is unknown. The aim of this study is to elucidate the underlying mechanism of PD-L1 expression regulation in the context of pancreatic cancer immune evasion. Pancreatic cancer mouse models and human specimens were used to determine PD-L1 and PD-1 expression and cancer immune evasion. Histone methyltransferase inhibitors, RNAi, and overexpression were used to elucidate the underlying molecular mechanism of PD-L1 expression regulation. All statistical tests were two-sided. PD-L1 is expressed in 60% to 90% of tumor cells in human pancreatic carcinomas and in nine of 10 human pancreatic cancer cell lines. PD-1 is expressed in 51.2% to 52.1% of pancreatic tumor-infiltrating cytotoxic T lymphocytes (CTLs). Tumors grow statistically significantly faster in FasL-deficient mice than in wild-type mice (P = .03-.001) and when CTLs are neutralized (P = .03-evasion. Targeting the MLL1-H3K4me3 axis is an effective approach to enhance the efficacy of checkpoint immunotherapy against pancreatic cancer. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Vikergallup : eesti kirjandus 2000 : [vastused Vikerkaare küsimustele

Index Scriptorium Estoniae

2001-01-01

Aut.: Epp Annus, Andres Aule, Veiko Belials, Jan Kaus, Andrus Kivirähk, Leo Luks, Hedda Maurer, Anneli Mihkelev, Marko Mägi, Aare Pilv, Jürgen Rooste, Aarne Ruben, Mihkel Samarüütel, François Serpent, Ivar Sild, Karl Martin Sinijärv, Jaak Urmet. 2000. a. parimaks uudisraamatuks tunnistati Andrus Kivirähu "Rehepapp ehk November" ja parimaks esikraamatuks Wimbergi [Jaak Urmet] "Maaaraamat"

UJI EFEKTIFITAS INSEKTISIDA NABATI EKSTRAK AKAR TUBA (Derris elliptica B. DAN UMBI GADUNG (Dioscorea hispida D. TERHADAP MORTALITAS DAN PERKEMBANGAN HAMA Plutella xylostella L. DI LABORATORIUM

Directory of Open Access Journals (Sweden)

irfan sugiono utomo

2017-06-01

Full Text Available Plutella xylostella L. merupakan hama penting tanaman kubis. Hama ini menyerang bagian daun dengan gejala daun menjadi berlubang sehingga turunnya produksi mencapai 80-100% penyebaran hama Plutella xylostella tersebar di daerah tropis dan subtropis.. Penelitian ini dilaksanakan di laboratorium Hama Tumbuhan Jurusan Hama dan Penyakit Tumbuhan Fakultas Pertanian Universitas Jember. Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL dan di uji menggunakan uji Beda Nyata Terkecil (BNT dengan taraf 5%. Perlakuan aplikasi yang digunakan dengan 2 metode, yaitu metode tetes (ulat dan metode celup (pakan. Perlakuan yang digunakan yaitu: K1 (Konsentrasi akar tuba 20ml/l air, K2 (Konsentrasi akar tuba 25ml/l air, K3 (Konsentrasi akar tuba 30ml/l air, K4 (Konsentrasi umbi gadung 20ml/l air, K5 (Konsentrasi umbi gadung 25ml/l air, K6 (Konsentrasi umbi gadung 30ml/l air, K7 (Konsentrasi akar tuba 20 ml/l air +umbi gadung 30ml/l air, K8 (Konsentrasi akar tuba 30 ml/l air +umbi gadung 20ml/l air. Pengamatan meliputi persentase mortalitas larva P. xlostella , persentase larva yang menjadi pupa, persentase larva yang menjadi imago Hasil penelitian menunjukkan bahwa Insektisida nabati akar tuba dan umbi gadung berpengaruh sangat nyata terhadap mortalitas larva Plutella xylostella yakni dapat menyebabkan tingkat mortalitas sebesar 86,67 % dengan konsentrasi paling efektif pada perlakuan K8 yaitu ektrak akar tuba 30ml/l air + umbi gadung 20ml/l air. Perlakuan ekstrak nabati akar tuba lebih efektif dengan metode celup sedangkan ekstrak umbi gadung lebih efektif dengan metode tetes. Penggunaan perlakuan kombinasi insektisida nabati lebih efektif dibandingkan dengan pemberian insektisida nabati tunggal.Kata kunci: Plutella xylostella, Akar tuba, Umbi gadung 

Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group.

Science.gov (United States)

Spector, Logan G; Davies, Stella M; Robison, Leslie L; Hilden, Joanne M; Roesler, Michelle; Ross, Julie A

2007-01-01

Leukemias with MLL gene rearrangements predominate in infants (birth weight, higher birth order, and prior fetal loss have, with varying consistency, been associated with infant leukemia, but no studies have reported results with respect to MLL status. Here, we report for the first time such an analysis. During 1999 to 2003, mothers of 240 incident cases (113 MLL(+), 80 MLL(-), and 47 indeterminate) and 255 random digit dialed controls completed a telephone interview. Odds ratios and 95% confidence intervals for quartile of birth weight, birth order, gestational age, maternal age at delivery, prior fetal loss, pre-pregnancy body mass index, and weight gain during pregnancy were obtained using unconditional logistic regression; P for linear trend was obtained by modeling continuous variables. There was a borderline significant linear trend of increasing birth weight with MLL(+) (P = 0.06), but not MLL(-) (P = 0.93), infant leukemia. Increasing birth order showed a significant inverse linear trend, independent of birth weight, with MLL(+) (P = 0.01), but not MLL(-) (P = 0.18), infant leukemia. Other variables of interest were not notably associated with infant leukemia regardless of MLL status. This investigation further supports the contention that molecularly defined subtypes of infant leukemia have separate etiologies.

Põlva Agro omanikud teenisid 200 miljonit / Liis Kängsepp

Index Scriptorium Estoniae

Kängsepp, Liis, 1981-

2008-01-01

2007. aastal toimus OÜ Põlva Agro enamusosaluse kokkuost Jaak Hinrikuse poolt, nüüdseks on ettevõte müüdud Leedu Agrowill Groupile. Vt. samas: Agrowill: suuri muutusi plaanis ei ole; Jaak Hinrikus: ostsime kokku, et säilitada kontrolli. Lisa: Agrowill Group; Põlva Agro. Diagrammid: Põlva Agro kasvatab kiirelt kasumlikkust; Agrowilli aktsia on kallinenud pärast börsiletulekut täpselt poole võrra. Tabel: Tähtsamad majandusnäitajad

[Diagnostic and Treatment Strategies in Morel-Lavallee Lesions in the Spinal Column and Pelvis].

Science.gov (United States)

Becker, Christopher A; Kammerlander, Christian; Greiner, Axel; Sommer, Fabian; Linhart, Christoph; Böcker, Wolfgang; Rubenbauer, Bianka; Weidert, Simon

2018-04-12

The Morel-Lavallée lesion is one of the concomitant soft tissue lesions of pelvic fractures. Its role in spine fractures and its treatment in combination with osteosynthesis of pelvic or spine fractures have not yet been determined. The aim of this study was to analyse the best diagnostic and treatment options of both spine and pelvic fractures combined with Morel-Lavallée lesions (MLL). An analysis of the literature was performed via PubMed and Medline. This revealed a total of 197 studies and case reports. After analysing the literature, 19 studies/case reports met our inclusion criteria. There are several diagnostic options for MLL, including ultrasound, computed tomography or MRI. In spinal and pelvic lesions, ultrasound is capable of detecting MLL. Some authors tend to perform open debridement of the MLL, whereas others recommend percutanous treatment. Open debridement and vacuum-assisted closure are recommended in late diagnosed MLL, where primary suture of the soft tissue is impossible. Fracture fixation should be performed simultaneously to treatment of the MLL. Broad-spectrum cephalosporins combined with an aminoglycoside or piperacilline/tazobactam should be initiated. Radical debridement and drainage are recommended, especially when MLL is diagnosed late. Repeated ultrasound examinations should be performed of the surrounding soft tissue of the fracture. When MLL is diagnosed within 2 days, percutanous fracture and MLL treatment should be performed. After more than 2 days, both fracture and MLL should be treated with open debridement, open fracture fixation and primary suture if possible. Georg Thieme Verlag KG Stuttgart · New York.

MicroRNA-205 downregulates mixed-lineage-AF4 oncogene expression in acute lymphoblastic leukemia

Directory of Open Access Journals (Sweden)

Dou L

2013-08-01

Full Text Available Liping Dou,1,* Jingxin Li,1,* Dehua Zheng,2,* Yonghui Li,1 Xiaoning Gao,1 Chengwang Xu,1 Li Gao,1 Lili Wang,1 Li Yu1 1Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of Hepatobiliary Surgery, Organ Transplant Center, Chinese PLA 309th Hospital, Beijing, People's Republic of China*These authors contributed equally to this workAbstract: Myeloid/lymphoid or mixed-lineage AF4 acute lymphoblastic leukemia (MLL-AF4 ALL is a pediatric leukemia that occurs rarely in adults. MLL-AF4 ALL is typically characterized by the presence of chromosomal translocation (t(4;11(q21;q23, leading to expression of MLL-AF4 fusion protein. Although MLL-AF4 fusion protein triggers a molecular pathogenesis and hematological presentations that are unique to leukemias, the precise role of this oncogene in leukemogenesis remains unclear. Previous studies have indicated that microRNAs (miRs might modulate the expression of MLL-AF4 ALL fusion protein, thereby suggesting the involvement of miR in progression or suppression of MLL-AF4 ALL. We have previously demonstrated that miR-205 negatively regulates transcription of an MLL-AF4 luciferase reporter. Here, we report that exogenous expression of miR-205 in MLL-AF4 human cell lines (RS4;11 and MV4-11 inversely regulates the expression of MLL-AF4 at both messenger RNA (mRNA and protein level. Furthermore, miR-205 significantly induced apoptosis in MLL-AF4 cells as evidenced by Annexin V staining using fluorescence-activated cell sorting (FACS analysis. The proliferative capacity of leukemic cells was suppressed by miR-205. The addition of an miR-205 inhibitor was able to restore the observed effects. In conclusion, these findings demonstrate that miR-205 may have potential value as a novel therapeutic agent in the treatment of MLL-AF4 ALL.Keywords: miR-205, MLL-AF4, leukemia, microRNA, oncogene expression, untranslated regions, proliferation

ERKÜ valimiste tulemused

Index Scriptorium Estoniae

2006-01-01

8. aprilli koosolekul kinnitas valimiste peakomitee XIX Esinduskogu liikmed: Mati Kõiva, Ylo Anson, Juhan Simonson, Airi Vaga, Gilda M. Karu, Taavo Virkhaus, Marju Rink-Abel, Markus Vaga, Eric Suuberg, Endel Reinpõld, Jaak Juhansoo, Ülle Ederma, Lya Karm, Heino Jõgis, Kersti Linask, Jaak Rakfeldt, Erik Puskar, Jüri Linask, Viiu Vanderer, Andres Kurrik, Mati Valdek Laan, Ilmar Vanderer, Henno Uus, Jüri Tults, Urmas Wompa, Astrid Jaanson, Jüri Virkus, Lilian G. G. Bein, Tiina Harris, Tõnu Vanderer

Modification of growth medium of mixed-culture species of microalgae isolated from southern java coastal region

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Sudibyo Hanifrahmawan

2018-01-01

Full Text Available Globally, there is growing interest in microalgae as production organisms. Microalgae contain lipids (oil, proteins and carbohydrates (sugars, and, especially marine algae have been used as food and feed for centuries. Recently, production cost reduction related to the supply of growth nutrients is necessary to make it profitable. Therefore, utilization of molasses, a byproduct of sugar production, as the natural carbon, macronutrients, and micronutrients sources can be helpful. The analysis showed that the content of sucrose, glucose, fructose, potassium, zinc, and magnesium was 68.4% w/w, 18.5% w/w, and 13.1% w/w, 5.5% w/w, 3.91 ppm, and 1,370 ppm respectively. This work aimed to determine the effect of molasses addition to the physio-chemical properties of multi-culture species of microalgae isolated from southern Java coastal region in Indonesia grown under mixotrophic culture. The cultivation in this work used medium which was self-formulated by the authors consisting of NaNO3 (5 mL/L, H3BO3 (1 mL/L, EDTA (1 mL/L, N2H2PO4 (5 mL/L, FeSO4 (1 mL/L, MgSO4 (1 mL/L, NaCl (1 mL/L, micronutrients (1 mL/L, vitamin B1 (1 mL/L, and vitamin B12 (1 mL/L in 500 mL of water. The medium will be treated to have molasses concentration of 0.05% v/v, 0.15% v/v, 0.25% v/v, 0.35% v/v, and 0.45% v/v.

PENGARUH PENAMBAHAN EFFECTIVE MICROORGANISM-4 (EM-4 PADA PENGOMPOSAN TERHADAP PRODUKSI JAMUR MERANG

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Adisti Yuliastrin

2016-09-01

Full Text Available This research was aimed for knowing the influence of  EM-4 (effective microorganism-4 addition and the most effective concentration of EM-4 in compost media for straw mushroom (Volvariella volvacea (Bull. ex Fr. Sing production. The treatment examined the use of EM-4 solution divided into six treatments and four repetitions. EM-4 concentration from 0 ml/l – 12,5 ml/l with an interval increasing of 2,5 ml/l. The addition of 7,5 ml/l – 12,5 ml/l concentration of EM-4 did not give so different result with the control media. Composting with addition of 5 ml/l EM-4 gave the highest straw mushroom production (2272,25 g. Statistically the result showed that the concentrations of EM-4 had no significant effect on the mushroom production.

Vikergallup : eesti kirjandus 2001 : [vastused Vikerkaare küsitlusele

Index Scriptorium Estoniae

2002-01-01

Aut.: Vahur Afanasjev, Veiko Belials, Piret Jaaks, Jan Kaus, Janek Kraavi, Priit Kruus, Leo Luks, Ilona Martson, Hedda Maurer, Anneli Mihkelev, Jürgen Rooste, Aarne Ruben, Mihkel Samarüütel, François Serpent, Ivar Sild, Karl Martin Sinijärv, Lauri Sommer, Jaak Urmet, Berk Vaher. 2001. a. parima uudisraamatu tiitlit jagasid Mehis Heinsaare "Härra Pauli kroonikad", Jan Kausi "Maailm ja mõni" ning Ene Mihkelsoni "Ahasveeruse uni"; parimaks esikraamatuks valiti Mehis Heinsaare "Vanameeste näppaja"

Multilayer Laue Lens: A Path Toward One Nanometer X-Ray Focusing

International Nuclear Information System (INIS)

Yan, H.; Stephenson, G.B.; Maser, J.; Yan, H.; Conley, R.; Kang, H.C.; Stephenson, G.B.; Kang, H.C.; Maser, J.; Conley, R.; Liu, Ch.; Macrander, A.T.

2010-01-01

The multilayer Laue lens (MLL) is a novel diffractive optic for hard X-ray nano focusing, which is fabricated by thin film deposition techniques and takes advantage of the dynamical diffraction effect to achieve a high numerical aperture and efficiency. It overcomes two difficulties encountered in diffractive optics fabrication for focusing hard X-rays: (1) small outmost zone width and (2) high aspect ratio. Here, we will give a review on types, modeling approaches, properties, fabrication, and characterization methods of MLL optics. We show that a full-wave dynamical diffraction theory has been developed to describe the dynamical diffraction property of the MLL and has been employed to design the optimal shapes for nano focusing. We also show a 16 nm line focus obtained by a partial MLL and several characterization methods. Experimental results show a good agreement with the theoretical calculations. With the continuing development of MLL optics, we believe that an MLL-based hard x-ray microscope with true nanometer resolution is on the horizon

Full Multilayer Laue Lens for Focusing Hard X-rays

International Nuclear Information System (INIS)

Liu Chian; Shi, B.; Qian, J.; Conley, R.; Yan, H.; Wieczorek, M.; Macrander, A. T.; Maser, J.; Stephenson, G. B.

2010-01-01

Multilayer Laue Lenses (MLLs) were developed by us using dynamic diffraction effects to efficiently focus hard x-rays to very small spots. Using a partial MLL we were able to focus 19.5-keV hard x-rays to a line focus of 16 nm with an efficiency of 31%. A full MLL is a complete linear MLL structure. It can be fabricated by bonding two partial MLL wafers, or by growing the full structure using magnetron sputtering without bonding. A 40-μm full MLL, with a total of 5166 layers of WSi 2 and Si, has been successfully grown by sputter deposition. The layer thicknesses gradually vary from 4 nm to ∼400 nm and then back to 4 nm. Two coating runs were used to grow the full structure, one for each half. It took over 56 h for each run. A 100-μm nearly-full MLL was constructed by bonding. Each 50-μm half-structure has 1788 WSi 2 and Si layers with 12-nm to ∼32-nm thicknesses and ∼32-μm total thickness, followed by a thick WSi 2 layer of ∼17 μm, and an AuSn layer of ∼1 μm. Both full MLL structures survived dicing and polishing. The primary results demonstrate the feasibility and potential of a full MLL with a doubled numerical aperture and large beam acceptance for hard x-rays.

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.

Science.gov (United States)

Santos, Margarida A; Faryabi, Robert B; Ergen, Aysegul V; Day, Amanda M; Malhowski, Amy; Canela, Andres; Onozawa, Masahiro; Lee, Ji-Eun; Callen, Elsa; Gutierrez-Martinez, Paula; Chen, Hua-Tang; Wong, Nancy; Finkel, Nadia; Deshpande, Aniruddha; Sharrow, Susan; Rossi, Derrick J; Ito, Keisuke; Ge, Kai; Aplan, Peter D; Armstrong, Scott A; Nussenzweig, André

2014-10-02

Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells. Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks, we speculated that DNA damage might also constrain leukaemic self-renewal and malignant haematopoiesis. Here we show that the histone methyl-transferase MLL4, a suppressor of B-cell lymphoma, is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL-AF9 oncogene. Deletion of MLL4 enhances myelopoiesis and myeloid differentiation of leukaemic blasts, which protects mice from death related to acute myeloid leukaemia. MLL4 exerts its function by regulating transcriptional programs associated with the antioxidant response. Addition of reactive oxygen species scavengers or ectopic expression of FOXO3 protects MLL4(-/-) MLL-AF9 cells from DNA damage and inhibits myeloid maturation. Similar to MLL4 deficiency, loss of ATM or BRCA1 sensitizes transformed cells to differentiation, suggesting that myeloid differentiation is promoted by loss of genome integrity. Indeed, we show that restriction-enzyme-induced double-strand breaks are sufficient to induce differentiation of MLL-AF9 blasts, which requires cyclin-dependent kinase inhibitor p21(Cip1) (Cdkn1a) activity. In summary, we have uncovered an unexpected tumour-promoting role of genome guardians in enforcing the oncogene-induced differentiation blockade in acute myeloid leukaemia.

EFEKTIVITAS PEMBERIAN URIN KELINCI UNTUK MENGURANGI DOSIS PUPUK ANORGANIK PADA BUDIDAYA PUTREN JAGUNG MANIS

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Chintia Fitriasari

2018-01-01

Increased production of sweet corn corn (Zea mays L. var. Indurata should be balanced with sufficient nutrients during its growth. The study was conducted from January to March 2017 at the Experimental Garden of the Faculty of Agriculture, University of Muhammadiyah Jakarta. The experimental design used was the Randomized Complete Block Design (RCBD with six treatments consisting of P0 (100% Inorganic fertilizer (Control; P1 (Rabbit urine 20 ml.l-1 of water + 50% inorganic fertilizer; P2 (Rabbit urine 25 ml.l-1of water + 50% inorganic fertilizer; P4 (Rabit urine 35 ml.l-1of water + 50% inorganic fertilizer; and P5 (Rabbit urine 40 ml.l-1of water + 50% inorganic fertilizer. Each treatment was repeated 4 times so that there were 24 experimental units, each units consists of 3 plants. The result, utilization of rabbit urine 25 ml.l-1of water + 50% inorganic fertilizer gives the highest value of plant height, leaf and widest leaf area. Utilization of rabbit urine 40 ml.l-1 of water + 50% inorganic fertilizer gives the fastest of flowering age of males and females. Utilization of rabbit urine 30 ml.l-1 of water + 50% inorganic fertilizer gives haighest value of total, length, diameter and the weight of cobs.

Nava tiigi ääres seiklevad Hunt ja Rebane / Liisi Seil ; kommenteerinud Pille Põllumäe

Index Scriptorium Estoniae

Seil, Liisi, 1971-

2009-01-01

17.-19. juulini Lilli külas Nava talus toimuvast 4. Nava lava festivalist. 19. 07 mängib Karksi valla kultuurikeskuse noorteteater "O" lasteetendust "Hundi ja Rebase lend lõunanabale", mille on Nava talu peremehe Jaak Kõdari raamatu "Kriimureinulised lood. 3, Argonaudid" põhjal kirjutanud ja lavastanud Silvia Soro. Kostüümid tegi Thea Ilusmets. 17., 18. ja 19. 07 mängitakse Jaak Kõdari mulgikeelset külanäitemängu "Kõik läheb mööda, kõik tuleb jälle. 1912-1918", lavastaja Silvia Soro

Sectioning of multilayers to make a multilayer Laue lens

International Nuclear Information System (INIS)

Kang, Hyon Chol; Stephenson, G. Brian; Liu Chian; Conley, Ray; Khachatryan, Ruben; Wieczorek, Michael; Macrander, Albert T.; Yan Hanfei; Maser, Joerg; Hiller, Jon; Koritala, Rachel

2007-01-01

We report a process to fabricate multilayer Laue lenses (MLL's) by sectioning and thinning multilayer films. This method can produce a linear zone plate structure with a very large ratio of zone depth to width (e.g., >1000), orders of magnitude larger than can be attained with photolithography. Consequently, MLL's are advantageous for efficient nanofocusing of hard x rays. MLL structures prepared by the technique reported here have been tested at an x-ray energy of 19.5 keV, and a diffraction-limited performance was observed. The present article reports the fabrication techniques that were used to make the MLL's

Immunophenotypic investigation of infant acute lymphoblastic leukemia

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A. M. Popov

2012-01-01

Full Text Available Aim of the study – immunophenotype description of infant acute lymphoblastic leukemia (ALL. 64 patients (29 boys and 35 girls with acute leukemia (AL aged from 0 to 11 months were included in the current study. ALL was found less frequently in infants than in older children (67.19 % and 87.69 %, respectively. BI-ALL was the most common immunological ALL type (60.46 % in infant ALL, while BII-ALL was notably less frequent compared with other age groups (30.23 %. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD10, CD20, CD45, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD10- and CD20-negativity, high CD45, CD15, CD65 and NG2 expression were immunophenotypic signatures of MLL-rearranged infant ALL, although NG2 had the highest diagnostic efficacy. High CD34 and CD65 expression was frequently associated with presence of MLL-AF4 fusion gene. Thus infants’ B-cell precursor ALL immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ ALL allows predicting presence of MLL rearrangements and NG2 is the most applicable single marker.

Immunophenotypic investigation of infant acute lymphoblastic leukemia

Directory of Open Access Journals (Sweden)

A. M. Popov

2014-07-01

Full Text Available Aim of the study – immunophenotype description of infant acute lymphoblastic leukemia (ALL. 64 patients (29 boys and 35 girls with acute leukemia (AL aged from 0 to 11 months were included in the current study. ALL was found less frequently in infants than in older children (67.19 % and 87.69 %, respectively. BI-ALL was the most common immunological ALL type (60.46 % in infant ALL, while BII-ALL was notably less frequent compared with other age groups (30.23 %. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD10, CD20, CD45, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD10- and CD20-negativity, high CD45, CD15, CD65 and NG2 expression were immunophenotypic signatures of MLL-rearranged infant ALL, although NG2 had the highest diagnostic efficacy. High CD34 and CD65 expression was frequently associated with presence of MLL-AF4 fusion gene. Thus infants’ B-cell precursor ALL immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ ALL allows predicting presence of MLL rearrangements and NG2 is the most applicable single marker.

Comparative toxicity of petrol and kerosene to periwinkle ...

African Journals Online (AJOL)

The comparative toxicities of two petroleum products, petrol and kerosene were examined by exposing Tympanotonus fuscatus to acute concentrations (60, 90, 120 and 150ml/L) of these toxicants for 96 hours. The 48th hour LC50 for petrol was 177.36 ml/L, while that of kerosene was 306.16 ml/L. The 96th hour LC50 was ...

Comparison of the effects of crude and spent oils on Tilapia ...

African Journals Online (AJOL)

Toxic effects of bonnylight crude and spent oils on Oreochromis niloticus fingerlings were conducted under laboratory conditions at the University of Port Harcourt, Nigeria for two months. Five concentrations (5 ml/L, 10 ml/L, 20 m1/L, 50 m1/L and l00 ml/L) of water soluble fraction (WSF) of crude and spent oils were ...

Effect of Post-Harvest Acetic Acid and Plant Essential Oils on Shelf-Life Extension of Tomato Fruits

International Nuclear Information System (INIS)

Salem, E.A.; Naweto, M.; Mostafa, M.

2013-01-01

In vitro effect of different concentrations of acetic acid on linear growth of Alternaria alternate was studied. The causal agent of tomato black rots in contact and fumigation showed that acetic acid inhibit A. alternata growth at 2 ml/L and on 0.8 ml/L in contact and fumigation, respectively. In vivo effect showed that acetic acid at 6 ml/L reduced severity of infection of tomato fruits from 53.5% to 4.8% after 3 weeks of storage in dipping method but at the strongest fumigation methods, acetic acid inhibit tomato fruits rot at 0.4 ml/L after 3 weeks of storage. In vitro effect of camphore (Eucalyptus globulus Labill), caraway (Carium carvum L.) and peppermint oil (Mentha piperita L.) at different concentrations were tested against Alternaria alternata, since caraway oil is the strongest oil effect on fungal growth followed by peppermint and camphore respectively. Similarly in in vivo caraway oil inhibit tomato fruits rots at 6 ml/L followed by peppermint that inhibited tomato rots at 8 ml / L but camphore reduced tomato rots at 8 ml/L from 40% to 8.1%. Accepted April 2013

Vormistatud ruumid 2010 / Kai Lobjakas

Index Scriptorium Estoniae

Lobjakas, Kai, 1975-

2011-01-01

Eesti Sisearhitektide Liidu 2010. a. preemia saanud töödest. Söögikoha interjööri preemia: kohvik Supelsaksad Pärnus (Ruth, Jaak ja Anna Huimerind), ühiskondliku interjööri preemia: ADM Interactive'i büroo Tallinnas (Tomomi Hayashi, Ahti Grünberg, Kerli Valk), ajaloolise interjööri preemia: Kihnu muuseum (Malle Jürgenson, Tea Tammelaan, Krista Lepland, Jaak Huimerind, Indrek Laos), näituse- ja installatsiooni kujunduse preemia: rändnäitus "Eesti kirjanik karikatuuris" (Janno Siimar, Kaarel Vahtramäe, Mart Lankots, Liina Jakobson), tudengipreemia - Aet Tera

Wedged multilayer Laue lens

International Nuclear Information System (INIS)

Conley, Ray; Liu Chian; Qian Jun; Kewish, Cameron M.; Macrander, Albert T.; Yan Hanfei; Maser, Joerg; Kang, Hyon Chol; Stephenson, G. Brian

2008-01-01

A multilayer Laue lens (MLL) is an x-ray focusing optic fabricated from a multilayer structure consisting of thousands of layers of two different materials produced by thin-film deposition. The sequence of layer thicknesses is controlled to satisfy the Fresnel zone plate law and the multilayer is sectioned to form the optic. An improved MLL geometry can be created by growing each layer with an in-plane thickness gradient to form a wedge, so that every interface makes the correct angle with the incident beam for symmetric Bragg diffraction. The ultimate hard x-ray focusing performance of a wedged MLL has been predicted to be significantly better than that of a nonwedged MLL, giving subnanometer resolution with high efficiency. Here, we describe a method to deposit the multilayer structure needed for an ideal wedged MLL and report our initial deposition results to produce these structures

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Energy Technology Data Exchange (ETDEWEB)

Smith, Matthew J.; Ottoni, Elizabeth; Ishiyama, Noboru; Goudreault, Marilyn; Haman, André; Meyer, Claus; Tucholska, Monika; Gasmi-Seabrook, Genevieve; Menezes, Serena; Laister, Rob C.; Minden, Mark D.; Marschalek, Rolf; Gingras, Anne-Claude; Hoang, Trang; Ikura, Mitsuhiko

2017-10-23

Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effector, AF6/afadin. We show here that AF6 employs a non-canonical, evolutionarily conserved α-helix to bind RAS, unique to AF6 and the classical RASSF effectors. Further, all patients with MLL-AF6 translocations express fusion proteins missing only this helix from AF6, resulting in exposure of hydrophobic residues that induce dimerization. We provide evidence that oligomerization is the dominant mechanism driving oncogenesis from rare MLL translocation partners and employ our mechanistic understanding of MLL-AF6 to examine how dimers induce leukemia. Proteomic data resolve association of dimerized MLL with gene expression modulators, and inhibiting dimerization disrupts formation of these complexes while completely abrogating leukemogenesis in mice. Oncogenic gene translocations are thus selected under pressure from protein structure/function, underscoring the complex nature of chromosomal rearrangements.

Guanicid and PHMG Toxicity Tests on Aquatic Organisms

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Eva Poštulková

2016-01-01

Full Text Available The emergence and development of new algicidal products is caused by the ever increasing popularity of garden ponds as well as the use of these products in the fisheries sector, especially for disposal of cyanobacteria and algae. Most frequent means of combating cyanobacteria and algae are applications of algicidal substances. Newly developed algaecides include Guanicid and polyhexamethylene guanidine hydrochloride (PHMG. The aim of the study was to identify toxic effects of Guanicid and PHMG on zebrafish (Danio rerio and green algae (Desmodesmus communis. We determined the acute toxicity in fish according to ČSN EN ISO 7346-1, and conducted the freshwater algae growth inhibition test according to ČSN ISO 8692 methodology. For inhibition tests with green algae we chose Guanicid and PHMG concentrations of 0.001, 0.005, and 0.010 ml/L. For fish short-term acute toxicity tests we chose Guanicid concentrations of 0.010, 0.050, 0.150, 0.200, 0.250, and 0.300 ml/L and PHMG concentrations of 0.010, 0.025, 0.050, 0.075, 0.100, and 0.125 ml/L. In case of zebrafish (Danio rerio, the LC50 value for Guanicid is 0.086 ml/L, while the LC50 value for PHMG is 0.043 ml/L. Effects of Guanicid on inhibition of green algae (Desmodesmus communis appear highly significant (p < 0.010 at a concentration of 0.010 ml/L. For PHMG, these effects are highly significant (p < 0.001 at concentrations of 0.005 and 0.010 ml/L in 48 hours.

Kunstielu / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2016-01-01

Kunstipoliitiline retoorika. Kunsti esteetilised paradigmad. Võimude pragmaatika. Majanduslik soosing ja poliitilised keelud. Kunstnike Liit. Näitused. Noortekoondis. Surve tugevnemine viis perestroikani. Kunstielu uuel ärkamisajal.

Kunstioksjonitest / Jaak Olep

Index Scriptorium Estoniae

Olep, Jaak, 1945-2000

1998-01-01

Sotheby ja Christie oksjonifirmadest. Kunstioksjonite korraldamisest Sotheby näitel. Venelaste ilmumisest oksjonitele 90ndate aastate alguses, Venemaa oma oksjonifirmadest. Hindadest maailmas. Šveitsi oksjonifirma Antiquorum oksjonist "Erootika ja seks kunstis".

Mehatroonik / Piret Jaaks

Index Scriptorium Estoniae

Jaaks, Piret, 1980-

2005-01-01

AS-i Overall Eesti juhi ja asutaja Andres Haameri elukäigust ning firma loomisest. Töökogemus, õppimine, usk iseendasse ja teistesse on need, mis aitasid realiseerida oma firma loomise ning tuua ettevõte tühjale turule. Lisa: Kuidas firma arenes

Can a Morel-Lavallée lesion be misdiagnosed as a mass like lesion?

Science.gov (United States)

Lee, Yoon Jae; Kim, Jun Hyeok; Kim, Ji Young; Han, Hyun Ho

2017-12-01

The Morel-Lavallée lesion (MLL) is a post-traumatic closed soft tissue degloving injury. Common complaints of MLL patients are a haematoma or fluid collection on the trunk or the lower extremity. However, the authors introduce unique cases of MLL that present an atypical appearance. The fluid collection was not apparent, and the capsule formation was not detected on preoperative image study. The main complaint of patients was the uncomfortable mass-like lesion that was regarded as a simple benign lump. The purpose of this case study is to introduce the atypical cases of MLL and to help other physicians make accurate diagnosis based on trial and error of our cases. © 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty.

Science.gov (United States)

Toro, Carlos A; Wright, Hollis; Aylwin, Carlos F; Ojeda, Sergio R; Lomniczi, Alejandro

2018-01-04

Polycomb group (PcG) proteins control the timing of puberty by repressing the Kiss1 gene in hypothalamic arcuate nucleus (ARC) neurons. Here we identify two members of the Trithorax group (TrxG) of modifiers, mixed-lineage leukemia 1 (MLL1), and 3 (MLL3), as central components of an activating epigenetic machinery that dynamically counteracts PcG repression. Preceding puberty, MLL1 changes the chromatin configuration at the promoters of Kiss1 and Tac3, two genes required for puberty to occur, from repressive to permissive. Concomitantly, MLL3 institutes a chromatin structure that changes the functional status of a Kiss1 enhancer from poised to active. RNAi-mediated, ARC-specific Mll1 knockdown reduced Kiss1 and Tac3 expression, whereas CRISPR-Cas9-directed epigenome silencing of the Kiss1 enhancer selectively reduced Kiss1 activity. Both interventions delay puberty and disrupt reproductive cyclicity. Our results demonstrate that an epigenetic switch from transcriptional repression to activation is crucial to the regulatory mechanism controlling the timing of mammalian puberty.

Mis on parem - Zaporozhets või Mercedes? / Andres Langemets

Index Scriptorium Estoniae

Langemets, Andres, 1948-

2007-01-01

Vastukaja Mikko Lagerspetzi artiklile 5. dets. Postimehes, mis oli omakorda vastukaja Jaak Aaviksoo artiklile 19. nov. Postimehes. Sotsioloogiast, sotsiaalteadlastest ja sotsioloogilistest küsitlustest

Julgesti, vennad, nüüd tööle : haiglajuht seletab valitsusele, et vajalik palgaraha on haigekassa reservis / Peep Põdder

Index Scriptorium Estoniae

Põdder, Peep, 1964-

2007-01-01

Jõgeva haigla juhataja kirjutab tervishoiuprobleemidest, pidades tervishoidu esimeseks julgeolekuküsimuseks ning kritiseerides ekssotsiaalminister Eiki Nestori tegevust ja andes nõu sotsiaalminister Jaak Aabile

Перемещение частных пространств = Transporting private spaces / Тоомас Паавер ; интервьюировал Владимир Фролов

Index Scriptorium Estoniae

Паавер, Тоомас, 1976-

2012-01-01

Tallinna linna tasuta ühistranspordist, transpordisüsteemi puudustest ja arengusuundadest. PAIK Arhitektide (Toomas Paaver, Jaak-Adam Looveer, Lauri Saar) Kristiine terminali projektist, jalgrattateedest

Innovation in the management of lessons learned in an IT project with the adoption of social media

Directory of Open Access Journals (Sweden)

Roberto Winter

2017-03-01

Full Text Available This research explores the gap in the management of lessons learned (MLL in an Information Technology project (IT, validating a model (named Target with the support of a wiki platform in a medium-sized company in the IT industry. This model supports the following MLL processes: awareness, collection, verification, storage, dissemination and reuse. This study adopts the paradigm of the Design Science Research and the Technical Action Research method to instantiate the Target model in the implementation phase of an IT project. The theoretical contribution lies in the practical utility of an LL model, which was validated in the field promoting innovation in the MLL. The practical implications can be seen in the company's learning to introduce the MLL, improve design productivity, increase employee collaboration and better disseminate knowledge.

Characterization of a multilayer Laue lens with imperfections

International Nuclear Information System (INIS)

Yan, H.; Kang, H.C.; Maser, J.; Macrander, A.T.; Kewish, C.M.; Liu, C.; Conley, R.; Stephenson, G.B.

2007-01-01

We present a simulation result of the focusing performance of a multilayer Laue lens (MLL) with imperfections. Imperfections we have studied correspond to deviations of sequence of layers in the fabricated structure from the zone plate law. The actual sequence of layers of the MLL is measured by scanning electron microscope (SEM), and fitted by second order polynomials. X-ray characterization of the MLL structures is performed using coherent X-rays at the Advanced Photon Source. We observe very good agreement between experiment and simulation. This demonstrates that our simulation method can serve as an efficient tool to characterize the focusing performance of MLLs with imperfections, and thereby allows us to provide feedback following deposition and fabrication of the MLL structures and optimization of focusing structures prior to X-ray characterization

Suurim kirjanduslik ja sotsialistlik võistlus / Aarne Ruben

Index Scriptorium Estoniae

Ruben, Aarne, 1971-

2004-01-01

Eesti kirjanikud Nõukogude Liidus 1920.-1930ndatel, kirjandusajakirjast "Leegid" (ilmus Leningradis a-tel 1926-1936). Ka Jaak Urmeti artiklist "Formalism marksistlikus kirjandusteaduses", Sirp, 2004, 23. apr

Dom, kotorõi postroil Iljin / Ella Agranovskaja

Index Scriptorium Estoniae

Agranovskaja, Ella, 1950-

2005-01-01

Viimased neli aastat on Vene Kultuurikeskuse direktoriks olnud Aleksandr Iljin. Vene Kultuurikeskusest on saanud arvestatav Tallinna kultuurikeskus. Kommenteerivad Riigikogu liikmed Ago-Endrik Kerge ja Jaak Allik

Pismo na kamne eto uzhe ne kamennõi vek / Ilja Sundelevitsh

Index Scriptorium Estoniae

Sundelevitsh, Ilja

2003-01-01

Jaak Visnapi ja Kadri Alesmaa litograafianäitusest "Stonerollers" Tallinna Linnagaleriis, ka litograafia-tehnikast. Briti Nõukogu korraldatud briti eliitdisaini näitusest "POSH" Tallinna Kunstihoone galeriis

Aaviksoo vihje : Reivik kaotab töö / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2008-01-01

Ärisidemete tekkimine Aivar Reiviku juhitava aktsiaseltsi Volta ja Vabadussõja võidusamba ehitaja Sans Souci vahel lõpetab Reiviku lepingu kaitseministeeriumiga. Kommenteerib kaitseminister Jaak Aaviksoo

Riigikokku pääseb läbi kolme sõela / Marko Suurmägi

Index Scriptorium Estoniae

Suurmägi, Marko, 1975-

2007-01-01

Kui iga erakonna üleriigilise nimekirja järjestus jääb samaks ka pärast valimisi, siis piirkondlik reastatakse pärast tulemuste selgumist saadud häälte arvu järgi ümber. Nii kerkib iga partei kõige rohkem hääli saanud liige esimeseks ja vähim toetust leidnud kandidaat viimaseks. Lisa: Võimalused. Isamaa ja Res Publica Liidu kandidaadi Helir-Valdor Seedri ja Rahvaliidu kandidaadi Jaak Alliku arvamus. Vt. samas lühiinter. valimistel osalevate erakondade esindajate Priit Toobali (Keskerakond), Meelis Atoneni (Reformierakond), Jaak Alliku (Rahvaliit), Helir-Valdor Seedri (Isamaa ja Res Publica Liit), Heiki Järveveeri (Sotsiaaldemokraatlik Erakond), Tanel Tammeti (Erakond Eestimaa Rohelised) ja Valentine Alvrega (Eesti Kristlikud Demokraadid)

Nostalgia Pühajärve kaldal / Paavo Kangur

Index Scriptorium Estoniae

Kangur, Paavo, 1966-

2006-01-01

Edgar Savisaare kunagise üleminekuvalitsuse ministrite kohtumisest Pühajärvel. Vt. samas: Eksriigiministri Raivo Vare toost; Eksmajandusministri Jaak Leimanni anekdoot naistest; Eksharidusminister Rein Loik arvab. Fotod

Inimeselt inimesele? Endalt iseendale. "In Graafika" / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2003-01-01

7. graafikafestival "IN Graafika". Näitused Pärnu kontserdimajas, Imatra kõrgema kunstikooli väljapanek Academia Gratas, Eesti Litograafiakeskusest (eestvedajad Kadri Alesmaa, Jaak Visnap), kus oli workshop

Controle da antracnose na pós-colheita de manga 'Ubá' com o uso de produtos alternativos

Directory of Open Access Journals (Sweden)

Lorena Moreira Carvalho Lemos

2013-12-01

Full Text Available Foi avaliada a eficácia de produtos alternativos aos agroquímicos no controle da antracnose na pós-colheita de mangas 'Ubá'. Frutos fisiologicamente maduros foram pulverizados até o completo molhamento, com suspensão de conídios de Colletotrichum gloeosporioides, na concentração de 2,5 x 10(5 conídios/mL. Após a secagem ao ar, foram pulverizados com água destilada (testemunha, tween 20 (8 mL/L de solução, Prochloraz (1,10 mL de Sportak 450 EC/L de solução, óleo de alho (10 mL/L + 8 mL/L de tween 20, óleo de amêndoa de Acrocomia aculeata + leite em pó instantâneo (LPI (25 mL/L+ 10 g LPI/L, óleo de amêndoa de A. aculeata + tween (25 mL/L + 8 mL/L de tween 20, biofertilizante agro-mos® (100 µL/L, óleo de neen (10 mL/L + 8 mL/L de tween 20, quitosana (10 mL/L + 8 mL/L de tween 20 e biomassa cítrica (10 mL/L + 8 mL/L tween 20.O solvente utilizado foi água destilada. Avaliaram-se o período de incubação, o período latente, a perda de massa fresca, a produção de CO² e, diariamente, a severidade e incidência da doença. Os períodos mais curtos de incubação da doença foram observados nos frutos tratados com óleo de neen, água + tween e biomassa cítrica, com aproximadamente cinco dias. O óleo de amêndoa de A. aculeata + LPI e agro-mos® foram os produtos que mais retardaram o aparecimento dos sintomas, impondo à doença o período de incubação de nove dias após a inoculação do patógeno. Quanto à severidade, o óleo de amêndoa de macaúba + LPI e o Prochloraz foram os mais eficientes em conter o crescimento do patógeno até o oitavo dia após a inoculação, sendo que, logo depois, os frutos tratados com óleo de amêndoa de A. aculeata + LPI se igualaram àqueles tratados com a maioria dos demais produtos. Os frutos tratados com óleo de amêndoa de A. aculeata + LPI e óleo de amêndoa de A. aculeata + tween manifestaram as estruturas do patógeno apenas após 13 e 14 dias de avalia

Effectiveness of ambon banana stem juice as immunostimulatory against Aeromonas hydrophila infections in catfish Clarias gariepinus

Directory of Open Access Journals (Sweden)

Qorie Astria

2017-07-01

Full Text Available ABSTRACT Outbreaks of infectious diseases due to Aeromonas hydrophila in catfish can cause high death rates (80–100%. Fish disease control can be done using phytopharmaceutical to prevent or treat diseases of fish. One of the phytopharmaceutical that known to prevent the fish diseases is ambon banana stem Musa cavendishii var. dwarf Paxton. This study was conducted to test the effectiveness of catfish immersion using banana stem juice as an immunostimulant against bacterial infections A. hydrophila. The observed parameters were a total performance of production, hematological test, and water quality. Immersion of catfish seeds with stem juice was performed at a concentration of 5 mL/L, 13 mL/L, and 21 mL/L for 30 minutes. Each treatment consisted of three replications. A  total of 15 fishes were immersed in 1.5 L water. At day-9 after immersion, fish was infected by A. hydrophila bacteria at a dose of 104 cfu/mL. The results showed that fish treated with banana stem juice at a concentration of 13 mL/L had the survival rate of 53.33±6.67% which is higher than positive control (33.33±6.67%. Based on hematology observations on the 3rd day post-challenge test (H12 with A. hydrophila, total erythrocytes, hemoglobin, total leukocytes, phagocytic activity, differential leukocyte, and lysozyme activity was highest in treatment13 mL/L. Lower feed conversion ratio (1.08±0.04 were also obtained in treatment 13 mL/L. Thus Immersion of seeds in stem juice can boost the immune system against infections A. hydrophila. Keywords: Aeromonas hydrophila, ambon banana stem juice, soaking, catfish, immune system  ABSTRAK Wabah penyakit akibat infeksi Aeromonas hydrophila pada ikan lele dapat menyebabkan tingkat kematian yang tinggi (80–100%. Penanggulangan penyakit ikan dapat dilakukan menggunakan fitofarmaka untuk mencegah ataupun mengobati penyakit ikan. Salah satu fitofarmaka yang dapat digunakan dalam upaya pencegahan penyakit ikan adalah batang

"Keisri hull" kui müstiline fantasy / Siimon Prii

Index Scriptorium Estoniae

Prii, Siimon

2006-01-01

30. sept. Ugalas esietendunud Jaan Krossi "Keisri hull" (autoridramatiseering), lavastajad Jaak Allik ja Peeter Tammearu. Kunstnik on Jaanus Laagriküll ja muusikaline kujundaja Peeter Konovalov. Peaosas Peeter Tammearu

Nõmme ja Kristiine piirikünkale Järvel kerkib sihvakas torn / Askur Alas

Index Scriptorium Estoniae

Alas, Askur, 1973-

2005-01-01

Järve keskuse naabrusesse ehitatavast 15-korruselisest büroohoonest, Böckleri majast. Autorid Studio Paralleeli arhitektid Jaak Huimerind ja Indrek Saarepera. Lisaks "Kõrghoonete katusevaated võiksid olla avalikud"

Rector's office as of 31 December 2006

Index Scriptorium Estoniae

2007-01-01

Rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Birute Klaas, administratsioonidirektor prof. Mihkel Pärnoja, finantsdirektor Taimo saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

"Röövlirahnu Martini" nõgesteta Eesti! / Asko Künnap

Index Scriptorium Estoniae

Künnap, Asko

2005-01-01

Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Jaak Urmet, R. Vilbre jt., produtsent ja operaator Manfred Vainokivi : helilooja Kaspar Jancis : Parunid ja Vonid, Taska Film, Amrion 2005

Rektoraat seisuga 31.12.2006

Index Scriptorium Estoniae

2007-01-01

Rektor prof. Jaak Aaviksoo, teadusprorektor prof. Ain Heinaru, õppeprorektor prof. Birute Klaas, administratsioonidirektor prof. Mihkel Pärnoja, finantsdirektor Taimo saan, haldusdirektor Riho Illak, akadeemiline sekretär Ivar-Igor Saarniit

Bonded Multilayer Laue Lens for focusing hard X-rays

International Nuclear Information System (INIS)

Liu Chian; Conley, R.; Qian, J.; Kewish, C.M.; Macrander, A.T.; Maser, J.; Kang, H.C.; Yan, H.; Stephenson, G.B.

2007-01-01

We have fabricated partial Multilayer Laue Lens (MLL) linear zone plate structures with thousands of alternating WSi 2 and Si layers and various outermost zone widths according to the Fresnel zone plate formula. Using partial MLL structures, we were able to focus hard X-rays to line foci with a width of 30 nm and below. Here, we describe challenges and approaches used to bond these multilayers to achieve line and point focusing. Bonding was done by coating two multilayers with AuSn and heating in a vacuum oven at 280-300 o C. X-ray reflectivity measurements confirmed that there was no change in the multilayers after heating to 350 o C. A bonded MLL was polished to a 5-25 μm wedge without cracking. SEM image analyses found well-positioned multilayers after bonding. These results demonstrate the feasibility of a bonded full MLL for focusing hard X-rays

Acute myocardial infarction during induction chemotherapy for acute MLL t(4;11 leukemia with lineage switch and extreme leukocytosis

Directory of Open Access Journals (Sweden)

Čolović Nataša

2015-01-01

Full Text Available Introduction. In patients with acute leukemias hemorrhage is the most frequent problem. Vein thrombotic events may appear rarely but arterial thromboses are exceptionally rare. We present a patient with acute leukemia and bilateral deep leg vein thrombosis who developed an acute myocardial infarction (AMI during induction chemotherapy. The etiology and treatment of AMI in patients with acute leukemia, which is a rare occurrence, is discussed. Case Outline. In April of 2012 a 37-year-old male presented with bilateral deep leg vein thrombosis and malaise. Laboratory data were as follows: Hb 118 g/L, WBC 354x109/L (with 91% blasts in differential leukocyte count, platelets 60Ч109/L. Bone marrow aspirate and immunophenotype revealed the presence of acute lymphoblastic leukemia. Cytogenetic analysis was as follows: 46,XY,t(4;11(q21:q23 [2]/62-82,XY,t(4;11[18]. Molecular analysis showed MLL-AF4 rearrangement. The patient was on low molecular weight heparin and combined chemotherapy according to protocol HyperCVAD. On day 10 after chemotherapy he got chest pain. Three days later AMI was diagnosed (creatine kinase 66 U/L, CK-MB 13U/L, troponin 1.19 μg/L. Electrocardiogram showed the ST elevation in leads D1, D2, aVL, V5 and V6 and “micro q” in D1. On echocardiography, hypokinesia of the left ventricle and ejection fraction of 39% was found. After recovering from AMI and restoring left ventricle ejection fraction to 59%, second course of HyperCVAD was given. The control bone marrow aspirate showed 88% of blasts but with monoblastic appearance. Flow cytometry confirmed a lineage switch from lymphoblasts to monoblasts. In further course of the disease he was treated with a variety of chemotherapeutic combinations without achieving remission. Eventually, palliative chemotherapy was administered to reduce the bulk of blasts. He died five months after the initial diagnosis. Conclusion. AMI in young adults with acute leukemia is a very rare complication

Põhjamaise taskuteatmik / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2005-01-01

Põhjamaade Ministrite Nõukogu Sleipniri stipendiaatide tööde näitus "Põhjamaine tunnetus" Eesti Rahva Muuseumis 14. I-27. II Tartu kunstikuu raames. Kuraator Jaak Visnap. Minna Hindi seeriast "Rannastseenid"

Auhind TÜ teadurile

Index Scriptorium Estoniae

2014-01-01

Kirjandusteooria teadur Jaak Tomberg pälvis maailma vanima teadusliku fantastika uurijaid koondava ühingu SFRA (Science Fiction Research Association) ühe oma kahest aastaauhinnast - eelmise aasta parima kriitilise artikli auhinna

Dokfilm "Elav jõud" osaleb kahel mainekal festivalil

Index Scriptorium Estoniae

2004-01-01

Andres Maimiku ja Jaak Kilmi dokumentaalfilmi "Elav jõud" on valitud Nyoni (Šveits) festivalile "Visions du Reel" ja Wiesbadenis toimuvale festivalile "goEast - Festival of Central and Eastern European Film"

Mirovaja kultura s dostavkoi na dom / Ilja Sundelevitsh

Index Scriptorium Estoniae

Sundelevitsh, Ilja

2003-01-01

Kunstinäitustest Tallinnas. Raul Meele käsikirjaliste tekstide (konkreetne luule) näitus "Kirjutatud lugu/kiri" Kastellaanimaja galeriis ja Jaak Arro segatehnikas inglipildid näitusel "Linnud" Kunstihoone galeriis

August toob Vainupeale kontserte

Index Scriptorium Estoniae

2006-01-01

Kontsertidest Vainupeal: Kunda suvekooli noored saksofonistid 10. aug., Jaan Arder ja Henn Rebane 15. aug., kunstinäituse "Blended X" sulgemiskontsert 19. aug., Silvi Vrait ja Jaak Jürisson 26. augustil

Eesti dokfilm sai Euroopast toetust

Index Scriptorium Estoniae

2005-01-01

Euroopa Liidu MEDIA Plus programm toetab kaht Eesti dokumentaalfilmi projekti : "Maria teatri fantoomid" (Baltic Film Production ; autor Marianna Kaat) ja "Müümise kunst" (Kuukulgur Film ; autorid Andres Maimik, Jaak Kilmi)

Kindlustuspakett kui Lego torn / Liina Leiten

Index Scriptorium Estoniae

Leiten, Liina

1999-01-01

Koduse vara kindlustamise tingimused. Tabelid: 1999.a. 1. kvartali usaldusreiting varakindlustuse osas, valik koduse vara kindlustamise hinnapakkumisi. Kommenteerivad maaklerfirma In Bro & Partners kindlustusdirektor Jaak Rikson ja Kindlustusabi OÜ direktor Toivo Voit

ESTO ühendab kõiki, kes tunnevad endid eestlastena / Kristel Sarrik ; fotod: Vaado Sarapuu; Kristel Sarrik; Karin Rumming

Index Scriptorium Estoniae

Sarrik, Kristel

2009-01-01

Jaak Juhansoo ja Mart Laanemäe kõnedest, dokumentaalfilmist "Peod täis pisaraid", Kristjan Randalu ja Bodek Janke kontserdist, näitustest, sõjaveteranide kokkutulekust, kirikukonverentsist, kontserdist "Generatsioonid" jpm.

Eesti Pindaros : K. J. Petersoni oodide vaimuloolisest taustast [2] / Jaan Undusk

Index Scriptorium Estoniae

Undusk, Jaan, 1958-

2012-01-01

Artikli teises osas vaadeldakse täpsemalt Pindarose saksakeelseid jäljendajaid ning jõutakse Tartu ülikooli professori Wilhelm Friedrich Hezeli ja Kristjan Jaak Petersoni kontaktideni nii õpingutes kui loomingus

Telepoisi kolmas tulemine / Jaanus Kulli

Index Scriptorium Estoniae

Kulli, Jaanus, 1955-

2008-01-01

ETV lastesaadete esimese telepoisi looja oli 1960. aastatel Jaak Palmse, 2000. aastatel "taastas" telepoisi Meelis Arulepp ja 2008.a. ilmus telepoiss ekraanile Daniel Müntineni ja animatsioonistuudio Birds of Paradise loominguna

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

DEFF Research Database (Denmark)

Sausen, Mark; Phallen, Jillian; Adleff, Vilmos

2015-01-01

tumour-specific mutations in the circulation of these patients. These analyses reveal somatic mutations in chromatin-regulating genes MLL, MLL2, MLL3 and ARID1A in 20% of patients that are associated with improved survival. We observe alterations in genes with potential therapeutic utility in over...... a third of cases. Liquid biopsy analyses demonstrate that 43% of patients with localized disease have detectable circulating tumour DNA (ctDNA) at diagnosis. Detection of ctDNA after resection predicts clinical relapse and poor outcome, with recurrence by ctDNA detected 6.5 months earlier than with CT...

Morel-Lavallée Lesion of the Knee in a Recreational Frisbee Player

Directory of Open Access Journals (Sweden)

Alison Shmerling

2016-01-01

Full Text Available Traumatic swelling/effusion in the knee region is a relatively common presenting complaint among athletes and nonathletes. Due to its broad differential diagnosis, a comprehensive evaluation beginning with history and physical examination are recommended. Knee joint effusion can be differentiated from other types of swelling by careful physical examination. Imaging, including plain radiography, ultrasound, and magnetic resonance imaging (MRI, is preferred modality. Aspiration of a local fluctuating mass may help with the diagnosis and management of some of these conditions. We present a case of a 26-year-old gentleman with superomedial Morel-Lavallée lesion (MLL of the knee with history of a fall during a Frisbee game. His MLL was successfully treated with therapeutic aspiration and compression wrap without further sequelae. MLL is a rare condition consisting of a closed degloving injury caused by pressure and shear stress between the subcutaneous tissue and the superficial fascia or bone. Most commonly, MLL is found over the greater trochanter and sacrum but in rare cases can occur in other regions of the body. In most cases, concurrent severe injury mechanisms and concomitant fractures are present. MLL due to sports injuries are very rare. Therapeutic strategies may vary from compression wraps and aspiration to surgical evacuation.

Tom ja Anni ajavad isad-emad naerma / Kai Väärtnõu

Index Scriptorium Estoniae

Väärtnõu, Kai

2007-01-01

ETV lastesaate "Saame kokku Tomi juures" stsenarist on Jaak Urmet ehk Wimberg. Teksti improviseerivad ka näitlejad Karol Kuntsel ja Maria Soomets. Lisaks tutvustus "Pööningule purjetab proua Õietolmutuust"

Malbe ja sihikindel Indrek Rahumaa / Väinu Rozental

Index Scriptorium Estoniae

Rozental, Väinu, 1957-

2007-01-01

Indrek Rahumaa suurosalusega investeerimisfond on viimase pooleteise aastaga investeerinud agressiivsesse laienemisse üle kolme miljardi krooni. Vt. samas: CV; Alta Capital tänavu hoogsalt laienenud. Kommenteerivad Eimar Rahumaa ja Jaak Raid

Jaan Klõšeiko soovitab: Jaan Tootseni film "Uus maailm"

Index Scriptorium Estoniae

2011-01-01

Režissöör Jaan Tootsen dokumentaalfilmi "Uus Maailm" (produtsent Jaak Kilmi, Kuukulgur Film, 2011) saamisloost ja filmist, mis valiti 25.-30. oktoobrini Tšehhis toimuvale Jihlava rahvusvahelisele dokumentaalfilmide festivalile

Tuul väljal / Ene-Reet Soovik

Index Scriptorium Estoniae

Soovik, Ene-Reet

1997-01-01

Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

Dead Men Risen: Estonian defence minister accuses me of 'fiction' and 'does not rule out going to court'

Index Scriptorium Estoniae

Harnden, Toby

2011-01-01

Raamatu "Dead Men Risen" autor räägib oma blogis Eesti kaitseministri Jaak Aaviksoo ja president Toomas Hendrik Ilvese reageeringutest teosele, kus on juttu ka Afganistanis teeninud Eesti kaitseväelastest

Filme meist ja meie ajast / Raimo Jõerand

Index Scriptorium Estoniae

Jõerand, Raimo

2007-01-01

EFSA filmiekspert teavitab uutest eesti tõsielufilmidest : Urmas E. Liivi "Casting" ja "Briljantroheline maja, pumbakaev ja valge laev", Andres Maimiku, Jaak Kilmi "Müümise kunst", James ja Maureen Tusty "Laulev revolutsioon"

Uus kord tõi nurina / Jaana Pikalev

Index Scriptorium Estoniae

Pikalev, Jaana

2010-01-01

IT-eksperdid Tõnu Samuel ja Jaan Jänesmäe peavad domeenireformi läbikukkunuks ning on koostanud avaliku kirja, milles kritiseerivad Eesti Interneti Sihtasutuse juhte Marek-Andres Kautsi ja Jaak Lippmaad

Afganistani draama: mida hukkunud Eesti sõdurite kohta varjata püütakse? / Teet Teder, Maarius Suviste

Index Scriptorium Estoniae

Teder, Teet

2011-01-01

Toby Harndeni raamatust "Dead Men Risen", kus on juttu ka Afganistanis teeninud Eesti kaitseväelastest. Kaitseminister Jaak Aaviksoo ja president Toomas Hendrik Ilvese reageeringutest. Vt. ka lk. 10: Uudam, Laur. Eetikapomm

Mida ihkab mu hing? / Toomas Raudam

Index Scriptorium Estoniae

Raudam, Toomas, 1947-

2003-01-01

Arvustus: Joyce, James. Pagulased : [näidend] / tõlkinud Jaak Rähesoo. Tallinn : Varrak, 2003. Ilmunud ka: Raudam, Toomas. Väike äratundmiste raamat. Tallinn : Eesti Keele Sihtasutus, 2006. Lk. 124-128

Decontamination of a municipal landfill leachate from endocrine disruptors using a combined sorption/bioremoval approach.

Science.gov (United States)

Loffredo, Elisabetta; Castellana, Giancarlo; Senesi, Nicola

2014-02-01

Sorption and biodegradation are the main mechanisms for the removal of endocrine disruptor compounds (EDs) from both solid and liquid matrices. There are recent evidences about the capacity of white-rot fungi to decontaminate water systems from phenolic EDs by means of their ligninolytic enzymes. Most of the available studies report the removal of EDs by biodegradation or adsorption separately. This study assessed the simultaneous removal of five EDs—the xenoestrogens bisphenol A (BPA), ethynilestradiol (EE2), and 4-n-nonylphenol (NP), and the herbicide linuron and the insecticide dimethoate—from a municipal landfill leachate (MLL) using a combined sorption/bioremoval approach. The adsorption matrices used were potato dextrose agar alone or added with each of the following adsorbent materials: ground almond shells, a coffee compost, a coconut fiber, and a river sediment. These matrices were either not inoculated or inoculated with the fungus Pleurotus ostreatus and superimposed on the MLL. The residual amount of each ED in the MLL was quantified after 4, 7, 12, and 20 days by HPLC analysis and UV detection. Preliminary experiments showed that (1) all EDs did not degrade significantly in the untreatedMLL for at least 28 days, (2) the mycelial growth of P. ostreatus was largely stimulated by components of the MLL, and (3) the enrichment of potato dextrose agar with any adsorbent material favored the fungal growth for 8 days after inoculation. A prompt relevant disappearance of EDs in the MLL occurred both without and, especially, with fungal activity, with the only exception of the very water soluble dimethoate that was poorly adsorbed and possibly degraded only during the first few days of experiments. An almost complete removal of phenolic EDs, especially EE2 and NP, occurred after 20 days or much earlier and was generally enhanced by the adsorbent materials used. Data obtained indicated that both adsorption and biodegradation mechanisms contribute

Tretjakova, Alavainu ja Johanson tuuritavad Ida-Virumaal

Index Scriptorium Estoniae

2004-01-01

5. apr. alustavad turneed Ida-Virumaal Ave Alavainu ja Tatjana Tretjakova, et esitleda oma luuleraamatut "2keelsed = 2jazõtshnõje" (Kärdla : A. Alavainu, 2004). Jaak Johanson laulab laule nimetatud autorite tekstidele

Kunstiteaduslik doktoritöö EKA-s kaitstud / Ingrid Ruudi

Index Scriptorium Estoniae

Ruudi, Ingrid

2005-01-01

Heie Treier "Kohalik modernsus kunstis. Eesti varamodernistliku kunsti teoreetiline ja ajalooline kontseptualiseerimine ning Karl Pärsimägi paradigmaleidmise perioodil". Juhendaja Thomas McEvilley, eelretsensent Katrin Kivimaa ja Ene Lamp. Oponent Jaak Kangilaski

Matriarhaat või patriarhaat - kas meeste päralt on ainult reede? : "M Klubi" 80! / Ela Tomson ; intervjueerinud Anti Einpaul

Index Scriptorium Estoniae

Tomson, Ela, 1945-

1998-01-01

Teleseriaal "M Klubi" uuel hooajal, stsenarist Toomas Kall, režissöör Roman Baskin : Baltic Entertainment Company. Võrdlus teiste seriaalidega. Arvamuse ütlesid Ela Tomson, Mati Põldre, Jaak Allik, Eino Baskin

Seltskond : [fotod] / tekst ja fotod Annika Haas

Index Scriptorium Estoniae

2008-01-01

8. dets. esitles Helle Michelson Eesti Lastekirjanduse Keskuses mälestusteraamatut "Lehitsetud leheküljed: Meenutusi elust ja lastekirjandusest" (Tallinn : Tänapäev, 2008) Kohal viibisid lastekirjanikud Ellen Niit, Jaak Urmet jt.

Ajakirjanikud ajasid metsas hundijälgi / Liisi Seil

Index Scriptorium Estoniae

Seil, Liisi, 1971-

2003-01-01

Hundiuurija Marko Kübarsepp viis teabepäevast "Elu koos hundiga" osalejad Soomaa metsadesse hundijälgi otsima. Kiskja kohta jagasid veel teavet Tõnu Traks, Ilmar Rootsi, Peep Männil ja Jaak Volmer

Two-state solutions

Index Scriptorium Estoniae

2011-01-01

16. detsembril Tartus toimunud Eesti-Läti koostöökonverentsist võtsid osa ka mõlema riigi peaministrid Andrus Ansip ja Valdis Dombrovskis. Kohal olid ka haridusministrid Jaak Aaviksoo ja Roberts Kilis

Plaadid / Kaur Garshnek, Ave Randviir, Priit Pruul...[jt.

Index Scriptorium Estoniae

2007-01-01

Uutest heliplaatidest Jaak Sooäär, Raul Vaigla, Tanel Ruben "No99 Jazzklubis", Black Strobe "Burn Your Own Church", The Quantic Soul Orchestra "Tropidelico", Uni "Kosmikud II", Bugge Wesseltoft "IM", Gabrielle "Always"

Peal on propaganda, all on tugev off / Valle-Sten Maiste

Index Scriptorium Estoniae

Maiste, Valle-Sten, 1972-

2008-01-01

Lõppeva teatriaasta repertuaarivalikust. Teatriaasta õnnestumiste ja ebaõnnestumiste kohta vastavad küsimustele ka Pille-Riin Purje, Jaak Allik, Rein Veidemann, Rait Avestik, Jim Ashilevi, Eva Kübar, Madli Pesti ja Madis Kolk

Imunisasi Ikan Jambal Siam dengan Vaksin Ichthyophthirius multifiliis

Directory of Open Access Journals (Sweden)

Henni Syawal

2010-09-01

Full Text Available An experiment on the immunization of Jambal Siam ( Pangasius hypophthalmus withIchthyophthirius multifiliis vaccine was conducted in the Laboratorium of Parasitic and Fish Diseases,Faculty Fisheries and Marine Science of Riau University, and Laboratorium of Fish Health of FacultyFisheries and Marine Science, IPB. The objective of the study was to enhance immune system of the fishfry on the ichthyophthiriasis diseases. The vaccine was prepared by prolonged treatment of theron in waterbath of 47°C for 30 minutes. The vaccine was administrated to fish by immersion in aquaria. A completelyrandomized design (CRD in factorial pattern (3 X 3 X 3 was carried out with dose and time as factors.Doses of treatment and time of immersion were of 1 ml/L, 2 ml/L and 3 ml/L as well as 15, 30 and 45minutes of treatment time respectively. To evaluate the effectiveness of vaccine in fish, a challenge test tofish was done at day 15 with theron 90.000 cell/ aquaria until rearing day 25 after vaccination. It revealedthat the best performance (p<0.5 were of dose 3 ml/L and time treatment of 15 minutes in that survivalrate of fish was 100% followed by dose 3 ml/L with time 45 minutes (63,3%. The total erythrocyte count,hematocrit level and hemoglobin of tested fish were fluctuated. The water quality were recorded including;dissolved oxygen range from 3,74 - 4,98 ppm; temperature 25 - 30°C and acidity of 4 - 6, quality were ofnormal range for fish. The optimal vaccine dose is 3 ml/l with 15 minute immersion.

Morel-Lavallee lesion.

Science.gov (United States)

Li, Hui; Zhang, Fangjie; Lei, Guanghua

2014-01-01

To review current knowledge of the Morel-Lavallee lesion (MLL) to help clinicians become familiar with this entity. Familiarization may decrease missed diagnoses and misdiagnoses. It could also help steer the clinician to the proper treatment choice. A search was performed via PubMed and EMBASE from 1966 to July 2013 using the following keywords: Morel-Lavallee lesion, closed degloving injury, concealed degloving injury, Morel-Lavallee effusion, Morel-Lavallee hematoma, posttraumatic pseudocyst, posttraumatic soft tissue cyst. Chinese and English language literatures relevant to the subject were collected. Their references were also reviewed. Morel-Lavallee lesion is a relatively rare condition involving a closed degloving injury. It is characterized by a filled cystic cavity created by separation of the subcutaneous tissue from the underlying fascia. Apart from the classic location over the region of the greater trochanter, MLLs have been described in other parts of the body. The natural history of MLL has not yet been established. The lesion may decrease in volume, remain stable, enlarge progressively or show a recurrent pattern. Diagnosis of MLL was often missed or delayed. Ultrasonography, computed tomography, and magnetic resonance imaging have great value in the diagnosis of MLL. Treatment of MLL has included compression, local aspiration, open debridement, and sclerodesis. No standard treatment has been established. A diagnosis of MLL should be suspected when a soft, fluctuant area of skin or chronic recurrent fluid collection is found in a region exposed to a previous shear injury. Clinicians and radiologists should be aware of both the acute and chronic appearances to make the correct diagnosis. Treatment decisions should base on association with fractures, the condition of the lesion, symptom and desire of the patient.

Eesti filmid võistlevad Rjazanis

Index Scriptorium Estoniae

2002-01-01

Rjazanis 22.-31. maini toimuval festivalil "Zolotoi Vitjaz" on konkursikavas ka Jaak Kilmi ja Andres Maimiku "Päkapikudisko", Hannes ja Renita Lintropi "Läbi pimeduse" ja Peeter Simmi "Elu pärast maailmalõppu"

Professor Peep Veski meie meenutustes

Index Scriptorium Estoniae

2014-01-01

Mälestusi Tartu Ülikooli Farmaatsia instituudi juhatajast Peep Veskist jagavad: Eve-Irene Lepist, Urve Paaver, Karin Kogermann, Kristian Semjonov, Jaak Koppel, Kristin Raudsepp, Imre Klebovich, Filiz Hincal, A. Atilla Hincal ja Elmar Arak

Antiputinlaste hingeelu / Olev Remsu

Index Scriptorium Estoniae

Remsu, Olev, 1947-

2009-01-01

Dokumentaalfilmist "Revolutsioon, mida ei tulnud", režissöör Aljona Polunina, produtsendid Jaak Kilmi ja Ilkka Matila, Kuukulgur Film ja Matila Röhr productions, 2008. Esilinastus Eestis kinos Sõprus 7. jaan. 2009

Kino nagu elu, mis on hullemgi veel / Mart Laar

Index Scriptorium Estoniae

Laar, Mart, 1960-

2009-01-01

Dokumentaalfilmist "Revolutsioon, mida ei tulnud", režissöör Aljona Polunina, produtsendid Jaak Kilmi ja Ilkka Matila, Kuukulgur Film ja Matila Röhr productions, 2008. Esilinastus Eestis kinos Sõprus 7. jaan. 2009

Vizit gotovnosti k sotrudnitshestvu

Index Scriptorium Estoniae

2008-01-01

Eestis viibis ametlikul külaskäigul Afganistani kaitseminister Abdul Rahim Wardak, kes kohtus president Toomas Hendrik Ilvesega ja kaitseminister Jaak Aaviksooga ning välisminister Urmas Paetiga. Vt. samas: Abdul Rakim Wardak

Balti näitlejad natside ja rüütlite vahel / Aarne Ruben

Index Scriptorium Estoniae

Ruben, Aarne, 1971-

2008-01-01

Dokumentaal-mängufilm nõukogude sõjafilmides fashiste kehastanud Baltimaade näitlejatest "Fritsud ja blondiinid" : režissöör Arbo Tammiksaar : produtsendid Jaak Kilmi, Askold Saulitis : Eesti - Läti 2008

Kohvik Supelsaksad = Supelsaksad Café

Index Scriptorium Estoniae

2011-01-01

Eesti Sisearhitektide Liidu 2010. a. söögikoha interjööri preemia pälvinud kohvikust Supelsaksad Pärnus Nikolai t. 32. Sisekujunduse autorid Anna Huimerind ja Ruth Huimerind. Arhitekt Jaak Huimerind

Poisid on halvad, poisid on head / Oudekki Loone

Index Scriptorium Estoniae

Loone, Oudekki, 1979-

2005-01-01

Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Kristian Taska, R. Vilbre, produtsent ja operaator Manfred Vainokivi : laulusõnade autor Jaak Urmet : tegevprodutsent Marju Lepp : Parunid ja Vonid, Taska Film, Amrion 2005

Focusing performance of a multilayer Laue lens with layer placement error described by dynamical diffraction theory.

Science.gov (United States)

Hu, Lingfei; Chang, Guangcai; Liu, Peng; Zhou, Liang

2015-07-01

The multilayer Laue lens (MLL) is essentially a linear zone plate with large aspect ratio, which can theoretically focus hard X-rays to well below 1 nm with high efficiency when ideal structures are used. However, the focusing performance of a MLL depends heavily on the quality of the layers, especially the layer placement error which always exists in real MLLs. Here, a dynamical modeling approach, based on the coupled wave theory, is proposed to study the focusing performance of a MLL with layer placement error. The result of simulation shows that this method can be applied to various forms of layer placement error.

Soovimatud lapsed / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

60-nda Cannes'i filmifestivali filme : Christian Mungiu "Neli kuud, kolm nädalat ja kaks päeva" (Rumeenia) ; Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Andrei Zvjagintsevi "Pagendus" (Izgnanije" ; muusika Arvo Pärdilt ; Venemaa) ; Kadri Kõusaare "Magnus"

Wow! Tallinn! / Jaak Rand

Index Scriptorium Estoniae

Rand, Jaak

2006-01-01

Jüri Sillarti mängufilm "Kuldrannake". Kunagise retrobändi kokkutulekut kujutava filmi stsenarist on Hans Luik oma näidendi "Tõe hetk" põhjal, operaator on Mait Mäekivi, produtsendid Kristian Taska ja Hans H. Luik, tootjafirmaks Taska Productions. Lisatud Jüri Sillarti filmograafia lk. 83

Pahupidi presidendikampaania / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2006-01-01

Autor leiab, et Tarvastu vallavolikogu koalitsiooni otsus presidendivalimistel Arnold Rüütlit mitte toetada on teatud erakondade negatiivne valimiskampaania. Ilmunud ka Põhjarannik, 2006/Apr/20, lk. 2 ; Meie Maa, 2006/Apr/20, lk. 2 ; Vooremaa, 2006/Apr/20, lk. 2 ; Sakala, 2006/Apr/18, lk. 2 ; Severnoje Poberezhje, 2006/Apr/20, lk. 2

Otepää piiskoplinnuse hävimisdaatumist / Ain Mäesalu

Index Scriptorium Estoniae

Mäesalu, Ain, 1955-

2010-01-01

Ülevaade, miks autor hakkas 1980. aastate keskel toetama hüpoteesi Otepää keskaegse linnuse hävimisest 1396. aastal. Samas on kriitiliselt vaetud sama ajakirja numbris mõningaid Jaak Mälli seisukohti

Komistusi ajaloo järskudel radadel / Vello Helk

Index Scriptorium Estoniae

Helk, Vello, 1923-2014

2007-01-01

kommentaare Olaf Kuuli, Magnus Ilmjärve ja Jaak Valge ajaloo-uurimustele, Ronald Reigani kõnest 12. juunil Brandenburgi värava juures, Venemaa ja Läänemaailma demokraatia erinevusest, vajadusest ajalooallikaid õigesti tõlgendada

Peeter Allik, Urmas Viik jt Londonis

Index Scriptorium Estoniae

2006-01-01

Eesti, Läti ja Leedu graafikute näitus "Power and Man. Three Countries. One Exhibition" galeriis Novas Gallery. Eestist osalevad Peeter Allik, Urmas Viik, Jaak Visnap, Kadri Alesmaa, Aili Vahtrapuu, Inga Heamägi

Eestikeelne doktoriõpe ähvardab kaduda / Eva Kübar

Index Scriptorium Estoniae

Kübar, Eva

2005-01-01

Eestikeelse doktoriõppe võimalikku kadumist kommenteerivad Tallinna Tehnikaülikooli õppeprorektor Jakob Kübarsepp, Tartu Ülikooli rektor Jaak Aaviksoo, Eesti Põllumajandusülikooli õppeprorektor Hardi Tullus ja Tallinna Ülikooli rektor Mati Heidmets

Vabadussõja võidusammas valmib Tšehhi klaasitehases / Dannar Leitmaa, Urmas Jaagant

Index Scriptorium Estoniae

Leitmaa, Dannar, 1982-

2008-01-01

Eesti kaitseminister Jaak Aaviksoo ja Tšehhi klaasivabriku Sans Souci esindaja Martin Chab allkirjastasid lepingu, mille kohaselt tšehhid projekteerivad, valmistavad ja püstitavad 15. oktoobriks Tallinna Vabaduse väljakule võidusamba

Q Vara ehitab tootmismaad laopargiks

Index Scriptorium Estoniae

2007-01-01

Kinnisvarafirma Q Vara OÜ alustab 2007. a. mais Rae vallas Tallinna ringtee ääres asuva 168000 m2 suuruse tootmismaa ümberehitamist laopargiks. Ettevõtte projektijuhi Jaak Puistma sõnul jagatakse laopark 22 krundiks

Kolm, keda miski ei seo / Veiko Märka

Index Scriptorium Estoniae

Märka, Veiko, 1964-

2004-01-01

Arvustus: Jõerüüt, Jaak. Uus raamat : [luuletused]. Tallinn : Tuum, 2004 ; Maiste, Juhan. In Arcadia ego : [luuletused]. Tallinn : J. Maiste, 2004 ; Essa, Maario. Kellegi teise muru : debüütluulekogu. Tallinn : SE & JS, 2004 ;

Development of a biochip-based assay integrated in a global strategy for identification of fusion transcripts in acute myeloid leukemia: a work flow for acute myeloid leukemia diagnosis.

Science.gov (United States)

Giusiano, S; Formisano-Tréziny, C; Benziane, A; Maroc, N; Picard, C; Hermitte, F; Taranger-Charpin, C; Gabert, J

2010-08-01

Three major types of rearrangements are involved in acute myeloid leukemias (AML): t(8;21)(q22;q22), inv(16)(p13q22), and 11q23/MLL abnormalities. Their precise identification becomes essential for diagnosis, prognosis, and therapeutic choices. Resulting fusion transcripts (FT) are also powerful markers for monitoring the efficacy of treatment, the minimal residual disease (MRD) and could become therapeutic targets. Today, the challenge is to propose an individual follow-up for each patient even for those with a rare fusion event. In this study, we propose a biochip-based assay integrated in a global strategy for identification of rare FT in AML, after fluorescence in situ hybridization detection, as described by the World Health Organization classification. Using cell lines, we developed and validated a biochip-based assay called the AMLFusionChip that identifies every FT of AML1-ETO, CBFbeta-MYH11 as well as MLL-AF9, MLL-ENL, MLL-AF6, and MLL-AF10. The original design of our AMLFusionChip.v01 enables the identification of these FT wherever the breakpoint on the partner gene may be. In case of biochip negative result, our 3'RACE amplification strategy enables to clone and then sequence the new translocation partner. This AMLFusionChip strategy fits into the concept of personalized medicine for the largest number of patients.

Uisutajad tõid presidendiproua kooli / Elina Randoja

Index Scriptorium Estoniae

Randoja, Elina

2011-01-01

Proua Evelin Ilves ja endine suusataja Jaak Mae külastasid 10. mail 2011 Tartu Katoliku Kooli, kus õpivad tänavuse noore sportlase preemia pälvinud iluuisutajatest õed Nanette Christine ja Naomi Charlotta Andersson

"See õpilasmalev on ikka täitsa tume maa" / Jaanus Kulli

Index Scriptorium Estoniae

Kulli, Jaanus, 1955-

2003-01-01

Stsenaristide-režissööride Jaak Kilmi ja Rene Reinumägi poolt läbiviidud castingutest filmi "Sigade revolutsioon" peaosaliste leidmiseks, valiti välja õpilased Uku Uusberg, Lilian Alto ja Jass Seljamaa

Perekond Raus ENSV kaitseliinil / Valdur Ohmann

Index Scriptorium Estoniae

Ohmann, Valdur, 1958-

2015-01-01

Põhjalikumalt Oskar Rausi ja Viktor Rausi elukäigust. Viktor Rausi seostest tuntud eesti kultuuritegelastega: Jaanus Orgulas, Voldemar Panso, Jaak Joala, Arvo Pärt, Leonhard Lapin, Jüri Arrak, Aarne Vahtra, Heinz Valk, Ott Arder jt.

Sportimine taastab juhi väsinud vaimu / Sigrid Suu

Index Scriptorium Estoniae

Suu, Sigrid

2003-01-01

Juhtide vaimsest ja füüsilisest tervisest, stressi ennetamisest ja tagajärgedest ning sportimis- ja lõõgastumisviiside valikust. Kommenteerivad Remet AS-i juht Tõnu Altnurme ja E.L.L. Kinnisvara juht Jaak Vende

Kas hakkas hirm võõrale maale ära kaduda? / Mööna Tilder

Index Scriptorium Estoniae

Tilder, Mööna

2010-01-01

Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis. Esietendus 9. dets. Tallinna Meistrite Hoovi teatrisaalis

Tantsuline vaade kodusele Eestimaale Aafrikast / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2009-01-01

9. dets. esietendub Tallinna Meistrite Hoovi teatrisaalis Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis

Kuumad tantsud ja Donki Hotid Eesti polaaröös / Margit Kask

Index Scriptorium Estoniae

Kask, Margit

2007-01-01

"Talveöö festival 2006" - "Söör Vantes. Donki Hot", lavastaja Dmitri Krõmov, Ghana tantsuansambli Kusum Gboo tantsusetendus "Somu" ja "Linnaelu kataloog" jaapanlase Issei Ogata esituses. Ka Jaak Alliku kommentaar festivalil nähtule

Eesti film kumab pimedas öös / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

1999-01-01

III Pimedate Ööde Filmifestivalil esilinastuvad Eesti-Läti ühisprojekt "Kolm lugu", kus ka Ervin Õunapuu "Kõrbekuu" ja Peeter Simmi "Aida" ning rahvusvaheline videokassett "Identiteet", kus ka Jaak Kilmi lühifilm "Inimkaamera"

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

Science.gov (United States)

Shinsky, Stephen A; Monteith, Kelsey E; Viggiano, Susan; Cosgrove, Michael S

2015-03-06

Mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases that are required for metazoan development. MLL1 is the best characterized human SET1 family member, which includes MLL1-4 and SETd1A/B. MLL1 assembles with WDR5, RBBP5, ASH2L, DPY-30 (WRAD) to form the MLL1 core complex, which is required for H3K4 dimethylation and transcriptional activation. Because all SET1 family proteins interact with WRAD in vivo, it is hypothesized they are regulated by similar mechanisms. However, recent evidence suggests differences among family members that may reflect unique regulatory inputs in the cell. Missing is an understanding of the intrinsic enzymatic activities of different SET1 family complexes under standard conditions. In this investigation, we reconstituted each human SET1 family core complex and compared subunit assembly and enzymatic activities. We found that in the absence of WRAD, all but one SET domain catalyzes at least weak H3K4 monomethylation. In the presence of WRAD, all SET1 family members showed stimulated monomethyltransferase activity but differed in their di- and trimethylation activities. We found that these differences are correlated with evolutionary lineage, suggesting these enzyme complexes have evolved to accomplish unique tasks within metazoan genomes. To understand the structural basis for these differences, we employed a "phylogenetic scanning mutagenesis" assay and identified a cluster of amino acid substitutions that confer a WRAD-dependent gain-of-function dimethylation activity on complexes assembled with the MLL3 or Drosophila trithorax proteins. These results form the basis for understanding how WRAD differentially regulates SET1 family complexes in vivo. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Siin oli Tammsaare töökabinet / Ilmar Palli

Index Scriptorium Estoniae

Palli, Ilmar, 1948-

2009-01-01

Külas Koitjärvel Kõvasoo talu taastanud Jaak Veisserikil. Vajadusest jäädvustada Koitjärvel A. H. Tammsaare mälestust: Tammsaare elas a-tel 1911-1919 (vaheaegadega) vend Jüri Hanseni Oru metsavahitalus

India äri eripära / Eda-Liis Kann

Index Scriptorium Estoniae

Kann, Eda-Liis, 1979-

2007-01-01

India antiikmööblit maale toova ID House juht Jaak Morna kirjeldab isikliku kogemuse kaudu India äritavasid ning töökorraldust. Lisa: India; Indiast saab triljonimajandus; Eesti-India majandussuhted; Kinnisvarahinnad teevad meile silmad ette

Hea nali võib peituda raamatus / Gert Kiiler

Index Scriptorium Estoniae

Kiiler, Gert

2007-01-01

Arvustus: Leer, Jaak. Savumees Einaril on kogu aeg buss katki. Tallinn : Jutulind, 2006 ; Huber, Markus, Treichler, Robert. Keegi pole nii vinge kui meie : uimased britid, tobedad sakslased, pinges prantslased ja veel 36 lootusetut juhtumit. Tallinn : Olion, 2006

Plaadid / Kaur Garshnek, Mart Niineste, Tui Hirv...[jt.

Index Scriptorium Estoniae

2008-01-01

Uutest heliplaatidest Tuule Kann/Jaak Sooäär "Õhtu ilu", The Mars Volta "The Bedlam In Goliath", Eva Dahlgren "Petroleum Och Tang", Lenny Kravitz "It's Time For A Love revolution", "Flyleaf ", New Project "Ultraviolent Light"

Uinutav dokumentaaldraama Vene äärmusopositsionääridest / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2009-01-01

7. jaanuaril esilinastub Tallinna kinos Sõprus dokumentaalfilm opositsionääridest Venemaal "Revolutsioon, mida ei tulnud" (režissöör Aljona Polunina, produtsent Jaak Kilmi; tootjad Kuukulgur Film ja Matila Röhr Productions Soomest, 2008)

DVD "Vesi peale" / Mari Peegel

Index Scriptorium Estoniae

Peegel, Mari, 1978-

2008-01-01

Lühiarvustus animafilmile "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : dubleerijad Harriet Toompere, Aarne Üksküla, Jaak Prints : Ameerika Ühendriigid (Dream Works) ja Suurbritannia (Aardman Animations) 2006

Täiskuu tervitas luulefestivali / Inge Põlma, Maire Kõrver

Index Scriptorium Estoniae

Põlma, Inge

2008-01-01

Ülevaade Täiskuu luulefestivalist, kus esinesid Kristiina Ehin, Andres Ehin, Ly Ehin, Contra, Sujata Bhatt, Ban'ya Natsuishi, Meelika Hainsoo, Lise Sinclair, Jaak Johanson, Lauri Õunapuu, Maria Peterson, Siiri Sisask, Kauksi Ülle, Sayumi Kamakura

DVD-d. Universitas Tartuensis 375 / Rain Kooli

Index Scriptorium Estoniae

Kooli, Rain

2007-01-01

Lühiarvustus DVD-le Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilmist "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Estinfilm 2007

Raamatututvustus

Index Scriptorium Estoniae

2008-01-01

2008. a. ilmunud artiklikogumikust "Koht ja paik = Place and location : studies in enviromental aesthetics and semiotics VI" (toimetajad Eva Näripea, Virve Sarapik, Jaak Tomberg), 2007. a. ilmunud Kalju Suure fotoalbumist "Järelhüppeid kultuurikihist. 2"

Immunophenotypic investigation of infant acute myeloid leukemia

Directory of Open Access Journals (Sweden)

A. M. Popov

2013-01-01

Full Text Available Aim of the study – characterization of immunophenotype in infant acute myeloid leukemia (AML. 90 patients (40 boys and 50 girls with acute leukemia (AL aged up to 365 days were included in the current study. AML was found more frequently in infants than in older children (26.67 % and 10.83 % respectively; p = 0.0002. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD99, CD61, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD61-negativity, high CD99, CD15, CD133 and NG2 expression were immunophenotypic signatures of MLLrearranged infant AML, although CD99 and NG2 had the highest diagnostic efficacy. Thus infants’ AML immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ AML allows predicting presence of MLL rearrangements by either CD99 or NG2 expression.

Immunophenotypic investigation of infant acute myeloid leukemia

Directory of Open Access Journals (Sweden)

A. M. Popov

2014-07-01

Full Text Available Aim of the study – characterization of immunophenotype in infant acute myeloid leukemia (AML. 90 patients (40 boys and 50 girls with acute leukemia (AL aged up to 365 days were included in the current study. AML was found more frequently in infants than in older children (26.67 % and 10.83 % respectively; p = 0.0002. Significant immunophenotypic differences were observed in patients with and without MLL gene rearrangements. Number of cases in those tumor cells expressed CD99, CD61, CD133, CD15, NG2 varied between MLL-positive and MLL-negative groups. CD61-negativity, high CD99, CD15, CD133 and NG2 expression were immunophenotypic signatures of MLLrearranged infant AML, although CD99 and NG2 had the highest diagnostic efficacy. Thus infants’ AML immunophenotype differs significantly due to the presence of MLL gene rearrangements. Diagnostic immunophenotyping of infants’ AML allows predicting presence of MLL rearrangements by either CD99 or NG2 expression.

Morel-Lavallee Lesion in the Upper Extremity.

Science.gov (United States)

Cochran, Grant K; Hanna, Kathryn H

2017-01-01

Background: The Morel-Lavallee lesion (MLL) is a closed internal degloving injury that results from shearing of the skin and subcutaneous tissue from the underlying fascia. Disruption of the perforating blood vessels and lymphatics results in a lesion filled with serosanguinous fluid and necrotized fat. MLLs are most commonly described in association with pelvic and lower extremity trauma, and there are limited reports of these lesions in other locations. Methods: This case report describes a 58-year-old male referred from his primary care physician with a soft tissue mass in the upper arm. Careful history discovered prior trauma with extensive bruising and MRI revealed a large encapsulated mass consistent with MLL. Results: An open debridement with excision of pseudocapsule was performed. Meticulous closure over a drain was performed and the patient healed without complication or recurrence. Intra-operative cultures were negative and pathology was consistent with MLL. Conclusion: MLL should always be considered in the setting of previous trauma regardless the location. In the chronic setting an open approach with excision of pseudocapsule can have an acceptable result.

A rare case of severe third degree friction burns and large Morel-Lavallee lesion of the abdominal wall.

Science.gov (United States)

Brown, Darnell J; Lu, Kuo Jung G; Chang, Kristina; Levin, Jennifer; Schulz, John T; Goverman, Jeremy

2018-01-01

Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. MLL is often overlooked in the setting of poly-trauma; therefore, clinicians must maintain a high degree of suspicion and be familiar with the management of such injuries, especially in obese poly-trauma patients. We present a 30-year-old female pedestrian struck by a motor vehicle who sustained multiple long bone fractures, a mesenteric hematoma, and full-thickness abdominal skin friction burn which masked a significant underlying abdominal MLL. The internal degloving caused significant devascularization of the overlying soft tissue and skin which required surgical drainage of hematoma, abdominal wall reconstruction with tangential excision, allografting, negative pressure wound therapy, and ultimately autografting. MLL is a rare, often overlooked, internal degloving injury. Surgeons must maintain a high index of suspicion when dealing with third degree friction burns as they may mask underlying injuries such as MLL, and a delay in diagnosis can lead to increased morbidity.

Nanometer Linear Focusing of Hard X Rays by a Multilayer Laue Lens

International Nuclear Information System (INIS)

Kang, H.C.; Stephenson, G.B.; Maser, J.; Liu, C.; Conley, R.; Macrander, A.T.; Vogt, S.

2006-01-01

We report on a type of linear zone plate for nanometer-scale focusing of hard x rays, a multilayer Laue lens (MLL), produced by sectioning a multilayer and illuminating it in Laue diffraction geometry. Because of its large optical depth, a MLL spans the diffraction regimes applicable to a thin Fresnel zone plate and a crystal. Coupled wave theory calculations indicate that focusing to 5 nm or smaller with high efficiency should be possible. Partial MLL structures with outermost zone widths as small as 10 nm have been fabricated and tested with 19.5 keV synchrotron radiation. Focal sizes as small as 30 nm with efficiencies up to 44% are measured

"Riik malelaual" = "Country on a Chessboard" / Tarmo Piirmets ; kommenteerinud Laura Kipper

Index Scriptorium Estoniae

Piirmets, Tarmo, 1974-

2015-01-01

Eesti Ajaloomuuseumi näitus "Riik malelaual. Saksa okupatsioon Eestis 1941-1944" Maarjamäe suvemõisa tallihoones, kuraator Olev Liivik. 19. sajandist pärit tallihoone renoveerimisest. Autor Tarmo Piirmets (Pink); arhitektid Jaak Huimerind, AB Studio Paralleel

Eesti tippteadlaste panus maailma : päästvad bakterid ja täiustatud elektroonika / koost. Jüri Allik

Index Scriptorium Estoniae

2007-01-01

Jüri Allik lappas maailma suurimat teaduskirjanduse andmebaasi ISI Web of Science. Enimviidatud Eesti teadlased on: Jaan Aarik, Jaak Jürimäe, Mati Karelson, Marco Kirm, Eero Vasar, Mihkel Zilmer, Ülo Niinemets, Kaupo Kukli, Enn Lust

Muusikalised jutustused

Index Scriptorium Estoniae

2008-01-01

Üritustest kontsertsarja Soul Spectrum raames Kumus: 14. märstsil Ursula Rucker (soojendusesinejad Riho Sibul, Jaak Sooäär ja Raul Saaremets), 15. märtsil folk-jazzlaulja Terry Callier (soojendusesinejad Tõnis Mägi ja Chalice)

Ja jälle filmitudengid! Voila! / Kristiina Davidjants

Index Scriptorium Estoniae

Davidjants, Kristiina, 1974-

2003-01-01

Tallinna Kinomajas linastunud TPÜ filmi ja video õppetooli operaatorite kursuse II õppeaasta kursusetööd-lühifilmid : "Tulemine" (Elen Lotman), "Duell" (Mart Arjukese, Kristjan-Jaak Nuudi), "Opus Negrum" (Peter Murdmaa) ja "What's the feeling" (Janek Karakatsh)

Vahutab nagu seep, aga puhtaks ei pese / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2005-01-01

Täispikk lastefilm "Röövlirahnu Martin" : stsenaristid Mihkel Ulman, Jaak Urmet, R. Vilbre jt. : režissöör Rene Vilbre : produtsent ja operaator Manfred Vainokivi : helilooja Kaspar Jancis : Parunid ja Vonid, Taska Film, Amrion 2005

Ants Orasest ja Anne Lange monograafiast / Jüri Talvet

Index Scriptorium Estoniae

Talvet, Jüri, 1945-

2005-01-01

Arvustus: Oras, Ants. Luulekool. I, Apoloogia / koostajad Hando Runnel ja Jaak Rähesoo. Tartu : Ilmamaa, 2003 ; Oras, Ants. Luulekool II, Meistriklass. Tartu : Ilmamaa, 2004 ; Lange, Anne. Ants Oras : [kirjandusteadlane, -kriitik ja tõlkija (1900-1982)]. Tartu : Ilmamaa, 2004

Remo Holsmer: mees Kalevi pingi taga / Remo Holsmer ; interv. Peep Lillemägi

Index Scriptorium Estoniae

Holsmer, Remo, 1980-

2009-01-01

Reformierakonna Tallinna piirkonnajuht Remo Holsmer vastab küsimustele, mis puudutavad tema tööd Kalevi korvpalliklubi managerina, korvpalli taset Eestis, Kalevisse välismängijate leidmist, Tallinna Kalev-Tartu Rock vastasseisu ning suhteid Jaak Salumetsaga

Galeriid / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

1999-01-01

Allen Jonesi litograafiate näitus galeriis "Vaal". Paul Rodgersi projektist Tartus Vanas anatoomikumis. Aili Vahtrapuu "Vee ruum" ja Jaak Soansi "Projektsioonid" Kunstihoone galeriis. Skulptorite ühenduse ideenäitus "Akvaarium" Rotermanni soolalao keldrisaalis. Idee autor Terje Ojaver.

Production of hydrogen and volatile fatty acid by Enterobacter sp. T4384 using organic waste materials.

Science.gov (United States)

Kim, Byung-Chun; Deshpande, Tushar R; Chun, Jongsik; Yi, Sung Chul; Kim, Hyunook; Um, Youngsoon; Sang, Byoung-In

2013-02-01

In a study of hydrogen-producing bacteria, strain T4384 was isolated from rice field samples in the Republic of Korea. The isolate was identified as Enterobacter sp. T4384 by phylogenetic analysis of 16S rRNA and rpoB gene sequences. Enterobacter sp. T4384 grew at a temperature range of 10-45 degrees C and at an initial pH range of 4.5-9.5. Strain T4384 produced hydrogen at 0-6% NaCl by using glucose, fructose, and mannose. In serum bottle cultures using a complete medium, Enterobacter sp. T4384 produced 1,098 ml/l H2, 4.0 g/l ethanol, and 1.0 g/l acetic acid. In a pH-regulated jar fermenter culture with the biogas removed, 2,202 ml/l H2, 6.2 g/l ethanol, and 1.0 g/l acetic acid were produced, and the lag-phase time was 4.8 h. Strain T4384 metabolized the hydrolysate of organic waste for the production of hydrogen and volatile fatty acid. The strain T4384 produced 947 ml/l H2, 3.2 g/l ethanol, and 0.2 g/l acetic acid from 6% (w/v) food waste hydrolysate; 738 ml/l H2, 4.2 g/l ethanol, and 0.8 g/l acetic acid from Miscanthus sinensis hydrolysate; and 805 ml/l H2, 5.0 g/l ethanol, and 0.7 g/l acetic acid from Sorghum bicolor hydrolysate.

Aleksander Simon / J. K.

Index Scriptorium Estoniae

Kukk, Jaak, 1904-2001

1992-01-01

Aleksander Simon õppis veterinaariat, kuid ei lõpetanud, korporatsiooni astus kohe selle asutamisel ja Jaak Kukk oli tema akadeemiline kasuisa, kellele anti teada, et 1944. a Saksamaale rännanud A. Simon üritas 1946 salaja Rootsi põgeneda

Piiriäärne lava valmistub taas esietenduseks / Margus Haav

Index Scriptorium Estoniae

Haav, Margus, 1969-

2008-01-01

Lõuna-Eestis Lilli külas algaval Nava lava festivalil tuuakse publiku ette Nava talu peremehe Jaak Kõdari näidend "Jukra", lavastaja Silvia Soro. Üht kandvat rolli mängib näitleja Lembit Eelmäe

Preemiad

Index Scriptorium Estoniae

2006-01-01

Riigi kultuuripreemia 2006 - Jaak Soans. Kultuuripreemia 2005. a. loominguliste saavutuste eest - Krista Kodres, Pekka Vapaavuori. Kultuurkapitali aastapreemiad 2005. Vaala kunstipreemia - Maarit Murka. Parimad "mitmikud". Pikemalt Hansapanga kunstipreemia laureaadist Mark Raidperest ja Massimo Martini Design Award 2006 saanud Pavel Sidorenkost

Taas teadmusühiskonna infopoliitikast / Silvi Metsar

Index Scriptorium Estoniae

Metsar, Silvi

2004-01-01

RRis toimunud II infopoliitika foorumil "Riiklik infopoliitika - müüt või tegelikkus" arutleti, kas Eestis on infoühiskond, milline on riiklik infopoliitika jne. Teiste seas osalesid Anu Toots, Tiiu Valm, Peeter Tulviste, Jaak Aaviksoo, Raul Malmstein

Eesti Hollywood ehk nädala jooksul tehakse kuut kodumaist filmi

Index Scriptorium Estoniae

2004-01-01

Toimetus ja Eesti Filmi Sihtasutuse peaekspert Jaak Lõhmus töös olevatest mängufilmidest : Peeter Simmi "Kontserdireis", Peeter Urbla "Stiilipidu", Rene Vilbre "Röövlirahnu Martin", Õ-Fraktsiooni "Malev" (režissöör Kaaren Kaer)

TÜ nõukogu nimetas neli uut professorit ja emeriitdotsendi

Index Scriptorium Estoniae

2012-01-01

TÜ nõukogu valis 2011.a. detsembri istugil professoriteks Helle Karro (sünnitusabi ja günekoloogia alal), Jaak Vilo (bioinformaatika alal), Varmo Vene (programmeerimiskeelte semantika alal), Marlon Dumas (tarkvaratehnika alal) ja emeriitdotsendiks majandusõppejõud Kersti Meiesaar

Erna kostitas Jakobi malevkonna kaitseliitlasi muda, vee ja villidega / Urmas Hännile

Index Scriptorium Estoniae

Hännile, Urmas

2003-01-01

Pärnumaa maleva liikmete muljeid Erna retkest. Vt. samas intervjuud Erna retke staabiülema, Rootsi Kuningriigi kaitseväe kolonelleitnanti Jaak Kallaku ja Hiina Rahvavabariigi Soome saatkonna sõjaväeatashee, brigaadikindrali Liu Mengiga. Tabel: "Erna Retk 2003"

Ülikooliga saab kohtuda ekraanil / Kerttu Jänese

Index Scriptorium Estoniae

Jänese, Kerttu, 1981-

2007-01-01

Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilm "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Estinfilm 2007. Filmist räägivad tegijad

Staff

Index Scriptorium Estoniae

2006-01-01

TÜ teadustöötajaist ja õppejõududest on 2/3 doktorikraadiga. TÜ rektor Jaak Aaviksoo ja teadusprprektor Ain Heinaru valiti Euroopa kõrghariduspoliitika juhtorganitesse. Sotsiaalteaduskonna prof. Wolfgang Drechsler sai Saksa-Eesti akadeemiliste suhete arendamise eest Saksamaa Liitvabariigi Teeneteristi

Tartu abiturientide elu võimalus: päev Ühendriikide sõjalaeva pardal / Mari-Liis Pintson

Index Scriptorium Estoniae

Pintson, Mari-Liis

2017-01-01

USA suursaadik James D. Melville juunior tegi Tartu Kristjan Jaak Petersoni gümnaasiumi kooliperele üllatuse ja kutsus rühma abituriente sel nädalal Tallinnas viibiva Ameerika Ühendriikide sõjalaeva USS Hué City pardale.

Ilmus esimene mahukam eestikeelne teatriajaloo ülevaade / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2007-01-01

25. jaan. esitleti Eesti Teatriliidus "Oxfordi illustreeritud teatriajaloo" eestikeelset versiooni. Tõlkeraamatu aluseks on 1995. aastal kirjastuses Oxford University Press ilmunud samanimeline raamat, mille koostajaks on John Russell Brown. Teose on tõlkinud Anne Lange, Ilona Kolberg, Piret Kruuspere, Kristjan Jaak Kangur

Tartu Ülikooli 86. aastapäeva tähistamine Torontos : "Põhjamaine järjekindlus ja hiinlase kannatus" / Tiina Ann Kirss ; fotod: V. Sarapuu

Index Scriptorium Estoniae

Kirss, Tiina, 1957-

2005-01-01

aktusega Tartu Collegéis 27. novembril 2005. Ülikooli rektor Jaak Aaviksoo analüüsis oma kõnes TÜ arenguvõimalusi ja päevamuresid, Tiina Kirss esitas sissevaate ülikooli ajalukku, muusikalises osas esinesid Kaili ja Riho Maimets

Eesti skulptor Argentiinas

Index Scriptorium Estoniae

1998-01-01

18.-25. juulini Resistencias toimunud rahvusvahelisel keskkonnaskulptuuride biennaalil osalenud Jaak Soans sai minimalistliku lehtrauast töö 'Ühendus' eest Nuovo Banco del Chaco eripreemia. I preemia - Raټl Pajáro Gomez, II - Thomas Kühnapfel, III - Eric Verhelst

Saaremaal valmib terasmehe häll / Aivo Vahemets

Index Scriptorium Estoniae

Vahemets, Aivo

2005-01-01

Eesti ettevõttes Michelle OÜ kaubamärgi all Inox Disain Lab toodetakse roostevabast terasest konstruktsiooniga voodeid. Ettevõtet juhib Jaak Kangro. Voodinäidised on Tallinnas Pärnu mnt. 22 ateljees või interneti koduleheküljel www.inox.ee

Jutt suusatamise surmast on liialdus / Toomas Huik, Deivil Tserp

Index Scriptorium Estoniae

Huik, Toomas

2007-01-01

Vt. ka Postimees : na russkom jazõke 5. märts, lk. 12. Kristina Shmigun tuli 30 km klassikasõidus kuuendaks, Jaak Mae 50 km klassikasõidus kaheksandaks ja Kaspar Kokk üheteistkümnendaks. Kommenteerib Eesti suusakoondise peatreener Mati Alaver

"Marilyn" korjas õunad endale / Tiina Sarv

Index Scriptorium Estoniae

Sarv, Tiina, 1949-

2007-01-01

Ugala tiigi ääres jagati 21. juunil Kuldõuna nime kandvaid publikupreemiaid. Kuldõuna laureaadid on "Marilyni" lavastaja Kalju Komissarov, kujundaja Jaak Vaus, nimosatäitja Hilje Murel ning lavastuses "Kolm klaasikest kirsiviina" silma paistnud näitleja Aarne Soro

Эстонский фильм взял приз на кинофестивале

Index Scriptorium Estoniae

2009-01-01

Itaalias Trieste filmifestivalil tunnistati parimaks dokumentaalfilmiks ja omistati Alpe Adria Cinema preemia filmile "Revolutsioon, mida ei tulnud" (režissöör Aljona Polunina, produtsendid Ilkka Matila ja Jaak Kilmi; tootjad Kuukulgur Film ja Matila Röhr Productions Soomest, 2008)

USA moos määrib Eesti naabritest mõjukamaks / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2007-01-01

Sel sügisel on toimunud mitu Eesti ja USA poliitikute kohtumist. Peaminister Andrus Ansipi ja kaitseminister Jaak Aaviksoo USA-visiitide korraldamisega kursis olevad ametnikud ei nõustu, et kohtumiste taga oleks olnud USA lobitöö Iraagi missiooni pikendamiseks

Eesti graafika etteaste Londonis / Urmas Viik

Index Scriptorium Estoniae

Viik, Urmas, 1961-

2006-01-01

Balti graafikanäitusest "Power and man" Londonis Novas galeriis. Eestit esindavad oma loominguga Peeter Allik, Urmas Viik, Kadri Alesmaa, Jaak Visnap, Inga Heamägi, Aili Vahtrapuu. Inglise skulptori Marc Quinni skulptuur rasedast Alison Lapperist Trafalgari väljakul

Tartlased lõid uut laadi tetrisemängu : eestlased pürivad miljarditurule / Kristiina Kruuse

Index Scriptorium Estoniae

Kruuse, Kristiina

2010-01-01

Uus iPhone´i mäng Wristbreaker, mille investorid on Sven Illingu ettevõte iCapital ja Mattias Linnap. Mängu loomisse on panustanud ka Gunnar Eelmäe, Jaak Ennuste ja Tartu Teaduspargis tegutsev ettevõte Indilo Wireless

The unique cultural voice : solo kannel, otsemaid / Olev Rood

Index Scriptorium Estoniae

Rood, Olev

2007-01-01

tutvustatakse Jaak Johansoni poolt Mäe talus Pringi külas Valgamaal salvestatud plaati kandlemängija ja -valmistaja Ilmar Tiidebergi muusikaga, kus plaadi 26 lugu on mängitud rahvamuusiku omavalmistatud kandlel (neid kokku on ta teinud üle 20)

Kihnu muuseum = Kihnu museum

Index Scriptorium Estoniae

2011-01-01

Eesti Sisearhitektide Liidu 2010. a. ajaloolise interjööri preemia pälvinud Kihnu muuseumist. Sisearhitektid: Malle Jürgenson, Tea Tammelaan, Krista Lepland (Laika, Belka & Strelka OÜ), loetletud nende ühiselt tehtud töid. Arhitektid: Jaak Huimerind, Indrek Laos

Klaasist võidusammas tuleb kõigi kirgede kiuste

Index Scriptorium Estoniae

2008-01-01

Tallinna Harjumäele kavandatava Vabadussõja võidusamba projekteerib, valmistab ja püstitab Tšehhi klaasifirma Sans Souci oktoobri keskpaigaks. Monument on plaanis avada 28. novembril 2008. Kommenteerib Jaak Aaviksoo. Vaata ka juhtkirja "Ässitajad arhitektid" lk. 2

Muuseum - market? Bach või Meie Mees? / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2005-01-01

28. septembril 2005. a. Rüütelkonna hoones toimunud avalikult arutelult muuseumi koha ja funktsiooni üle tänapäeva ühiskonnas. Vestlusringis Jaak Kangilaski, Rein Raud, Eha Komissarov, Merike Lang, Johannes Saar, Anders Härm, Sirje Helme jt

Eesti rahvusliku tahte triumf? / Tarmo Jüristo

Index Scriptorium Estoniae

Jüristo, Tarmo

2010-01-01

Autor analüüsib kaitseminister Jaak Aaviksoo Tartu rahu aastapäevale pühendatud kõnet, milles kaitseminister viitas tahtmatult 1934. aasta propagandafilmile "Tahte triumf" ("Triumph des Willens"), mis kujutas Adolf Hitleri saabumist natsionaalsotsialistliku partei Nürnbergi konverentsile

PÖFF-i filmiturul Baltic Event sünnivad tuleviku kinomagnetid / Kristiina Davidjants

Index Scriptorium Estoniae

Davidjants, Kristiina, 1974-

2008-01-01

12. PÖFFiga kaasnes ka Tallinnas 30. novembrist 3. detsembrini toimunud filmiturg Baltic Event, millel stsenaariumi staadiumis olevad filmiprojektid otsivad maailma filmitööstuse esindajatest koostööpartnereid. Eestist osales Jaak Kilmi ja Artur Talviku projekt "Rahad ette"

Tartu Ülikool esitleb juubelialbumit ja dokumentaalfilmi

Index Scriptorium Estoniae

2007-01-01

Tartu Ülikooli 375. aastapäeva puhul esitletakse ülikooli kohvikus kinkeraamatut "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

Alma mater sõnas, pildis ja helis / Varje Sootak

Index Scriptorium Estoniae

Sootak, Varje, 1946-

2007-01-01

Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

Postimees hääletas võitjaks Korea filmi "Tühi maja"

Index Scriptorium Estoniae

2004-01-01

Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindas 5-palli süsteemis viis asjatundjat : Sulev Teinemaa, Kristiina Davidjants, Olev Remsu, Jaak Allik Ja Giuseppe Gariazzo. Kõik esitavad oma hinnangu lühikokkuvõtte. Lisatud lõplik tabel

Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.

Directory of Open Access Journals (Sweden)

Mai Nanya

Full Text Available Etoposide, a topoisomerase 2 (TOP2 inhibitor, is associated with the development of KMT2A (MLL-rearranged infant leukemia. An epidemiological study suggested that in utero exposure to TOP2 inhibitors may be involved in generation of KMT2A (MLL rearrangement. The present study examined the mechanism underlying the development of KMT2A (MLL-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model. Fetal liver hematopoietic stem cells were more susceptible to etoposide than maternal bone marrow mononuclear cells. Etoposide-induced Kmt2a breakage was detected in fetal liver hematopoietic stem cells using a newly developed chromatin immunoprecipitation (ChIP assay. Assessment of etoposide-induced chromosomal translocation by next-generation RNA sequencing (RNA-seq identified several chimeric fusion messenger RNAs that were generated by etoposide treatment. However, Kmt2a (Mll-rearranged fusion mRNA was detected in Atm-knockout mice, which are defective in the DNA damage response, but not in wild-type mice. The present findings suggest that in utero exposure to TOP2 inhibitors induces Kmt2a rearrangement when the DNA damage response is defective.

USA kaitseminister Robert Gates süüdistas liitlasvägesid oskamatuses / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2008-01-01

USA kaitseminister Robert Gates väitis ajalehes The Los Angeles Times avaldatud intervjuus, et Lõuna-Afganistani olukord on halvenenud seal võitlevate USA liitlasvägede puuduliku väljaõppe tõttu. Liitlasriikide reageeringuid. Arvamust avaldavad Jaak Aaviksoo, Kaarel Kaas

101 riigikogulast said valijalt ehmatava liputervituse / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 4. sept. lk. 4. Valija Tiina Talts saatis presidendivalimiste esimese päeva hommikul parlamendiliikmetele kirja, mille juurde oli ümber disainitud Eesti lipp. Vastused saatsid neli saadikut, nende hulgas Mait Klaassen, Jaak Allik, Janno Reiljan

Ühinemine on kohapealse arengu seisukohalt strateegiline otsus / interv. Helle Ruusing

Index Scriptorium Estoniae

2008-01-01

Riigikogu liikmed Jaak Aab ja Rein Aidma, regionaalminister Siim-Valmar Kiisler, Linnade Liidu tegevdirektor Jüri Võigemast, Maaomavalitsuste Liidu tegevdirektor Ott Kasuri ja Tallinna Ülikooli avaliku poliitika professor Georg Sootla arutavad vestlusringis kohalike omavalitsuse õigusi ja kohustusi, liitumise olulisust ja haldusreformi arenguperspektiive

Viljandi sõudeelling = Viljandi Rowing Slipway / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Viljandis Ranna pst. 13 asuva sõudeellingu arhitektuursest lahendusest. Arhitektid Lauri Saar, Toomas Paaver, Indrek Järve (Paik Arhitektid OÜ), kaasautorid Jaak-Adam Looveer, Tõnu Laanemäe. Žürii liige Kalle Komissarov žürii hinnangust kultuurkapitali aastapreemiale esitatud ehitisele

Tõrvapott ja meetilgad / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2002-01-01

Ilmunud ka: Põhjarannik ; Severnoje Poberezhje 2. oktoober lk. 2. Riigikogu liikmete palgast ja ametihüvedest. Autor: Rahvaerakond Mõõdukad. Vt. samas küsitlus Kuidas suhtute Riigikogu liikmete peaaegu kontrollimatutesse hüvitistesse? Vastavad: Eri Klas, Jaak Mae, Kuno Pajula, Mati Unt

Raamat Läänemere vägilastest - jäälõhkujatest / Taavi Kelder

Index Scriptorium Estoniae

Kelder, Taavi

2006-01-01

rets. rmt.: "Suur Tõll" ja teised Eesti jäämurdjad/Vladimir Kopelman, Jaak Sammet, Peedu Sammalsoo...[jt.]; koostaja Mati Õun. Tallinn: Sentinel, 2005. 98 lk. : ill. Tiitellehel ka autorid: Mati Õun, Olaf Vaarmaa, Heino Arumäe, Roman Matkiewitcz

ÜEKNi 2005. aasta peakoosolek : ESTO 2008, resolutsioon, uus esimees / foto: V. Sarapuu

Index Scriptorium Estoniae

2005-01-01

8. - 9. aprillil 2005 New Yorgis toimunud Ülemaailmse Eesti Kesknõukogu peakoosolekul kinnitati Inglismaa Eestlaste Ühingu soovil ESTO 2008 toimumise kohaks Inglismaa. Kesknõukogu uueks esimeheks valiti Jaak Juhansoo, Juhan Simonsoni vääristati Kanada eestlaste teenetemärgiga

Programma EQUAL : ravnõe vozmozhnosti na rabote / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2006-01-01

Tallinnas toimunud 23 Euroopa Liidu liikmesriigi EQUAL programmile pühendatud foorumist, mille eesmärgiks on vähendada diskrimineerimist töökohtadel. Eestis EQUAL programmi raames töötavatest projektidest. Foorumist võttis osa ka sotsiaalminister Jaak Aab. Lisa

Endiste tartlaste käekõrval kiirrongiga läbi 375-aastase Tartu Ülikooli ajaloo / Tõnis Arro

Index Scriptorium Estoniae

Arro, Tõnis, 1960-

2011-01-01

Tartu Ülikooli 375. aastapäeva puhul valminud dokumentaalfilm "Universitas Tartuensis 375" : stsenaristid Jaak Lõhmus ja Lauri Vahtre : režissöörid Rene Vilbre ja Märten Vaher : Tartu Ülikool, Estinfilm ja Eesti Rahvusringhääling, 2007

Helsingi loomaaia jääskulptuuridest valiti parimad

Index Scriptorium Estoniae

2004-01-01

Soomes Korgeasaaris lõppes jääskulptuurivõistlus. Võitjad. Esikohatöö autorid olid Steve Lester Ameerikast ja Ljudmila Lester Venemaalt. Eestist osalesid ühel võistlusel Lembit Palm ja Jaak Soans ning teisel võistlusel Tiiu Kirsipuu ja Aime Kuulbusch

Popmuusika / Margus Haav

Index Scriptorium Estoniae

Haav, Margus, 1969-

2006-01-01

Uutest heliplaatidest Fort Minor "The Rising Tied", KT Tunstall "Eye To The Telescope", David Bowie "The Platinum Collection", Beats And Styles "Everything Is Everything", Mikko Innanen, Jaak Sppäär and Han Bennink "Spring Odyssey", RinneRadio, Tok Tok Tok "A Wish"

THE ACTION OF CORAGEN INSECTICIDE ON CERTAIN PHYSIOLOGICAL BIOMARKERS ON CARASSIUS AURATUS GIBELIO BLOCH L. 1758

Directory of Open Access Journals (Sweden)

Claudiu Alexandru Baciu

2015-12-01

Full Text Available In our researches we have determined the variation of certain physiological indexes, such as the oxygen consume, the breathing rhythm, the glycaemia and the number of red blood cells under the action of Coragen insecticide on Carassius auratus gibelio Bloch. Under the action of Coragen, we have registered significant changes in the oxygen consume, the breathing rhythm, the number of red blood cells and glycemia at the Carassius auratus gibelio Bloch items, considered as answers to the stress provoked by emissions. The highest variations of the physiological indexes, from the perspective of the percentage, were noticed at the glycemia, which at the mark was 28 mg/dl, and in the treated sample, with 0.1 ml/l Coragen is 42 mg/dl, representing a 50% growth and at the breathing rhythm in 24 hours, where values significantly decreased with 41.18% at the concentration of 0.07 ml/l and with 39.33% at the concentrations of 0.05 and 0.1 ml/l Coragen. The slightest variations of the physiological indexes, from the perspective of percentage, were noticed at the oxygen consumption, which, at the mark is of 55.302 ml oxygen/kg/hour, and for the treated sample, with 0.1 ml/l Coragen is 34.81 ml oxygen/kg/hour, representing a decrease of 37.06% in 24 hours and the number of red blood cells, where the values have significantly decrease with 9.58%, 13.48%, respectively 18.44% for the concentrations of 0.05, 0.07 and 0.1 ml/l Coragen.

Focusing of hard x-rays to 16 nanometers with a multilayer Laue lens

International Nuclear Information System (INIS)

Kang, Hyon Chol; Yan Hanfei; Winarski, Robert P.; Holt, Martin V.; Maser, Joerg; Liu Chian; Conley, Ray; Vogt, Stefan; Macrander, Albert T.; Stephenson, G. Brian

2008-01-01

We report improved results for hard x-ray focusing using a multilayer Laue lens (MLL). We have measured a line focus of 16 nm width with an efficiency of 31% at a wavelength λ=0.064 nm (19.5 keV) using a partial MLL structure with an outermost zone width of 5 nm. The results are in good agreement with the theoretically predicted performance

Lumbar Morel-Lavallée lesion: Case report and review of the literature.

Science.gov (United States)

Zairi, F; Wang, Z; Shedid, D; Boubez, G; Sunna, T

2016-06-01

The Morel-Lavallée lesion (MLL) is a rarely reported closed degloving injury, in which shearing forces have lead to break off subcutaneous tissues from the underlying fascia. Lumbar MLL have been rarely reported to date, explaining that patients are frequently misdiagnosed. While patients could be treated conservatively or with non-invasive procedures, delayed diagnosis may require open surgery for its cure. Indeed, untreated lesions can cause pain, infection or growing subcutaneous mass that can be confused with a soft tissue tumor. We report the clinical and radiological features of a 45-year old man with voluminous lumbar MLL initially misdiagnosed. We also reviewed the relevant English literature to summarize the diagnostic tools and the main therapeutic options. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Siidii / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2003-01-01

Heliplaatidest: Millenia Nova "Narcotic Wide Screen Vista", Trygve Seim "Different Rivers", Eesti Keeled ja Jaak Johanson, Riho Sibul "Sabaga Täht", Peeter Vähi, Fedor Vetkalov, Dmitri Tkachenko "Best Regards From Tallinn And Moscow", Brainstorm "A Day Before Tomorrow", Allegri, Pärt, Tormis "Light"

Kahtlus närtsitab Merkot / Toomas Annus ; interv. Ralf-Martin Soe

Index Scriptorium Estoniae

Annus, Toomas, 1960-

2008-01-01

Altkäemaksukahtlustus viib Merkolt lepinguid. Küsimustele vastab Merko suuromanik Toomas Annus. Vt. samas: Haavatud Merko kutsub aktsionärid appi; Jaak Saarniit: riigihangete puhul Merkot nurka ei visata; Milles Merko Ehitust süüdistatakse?; Merkot ootab aastatepikkune vaidlus; Diagramm: Aktsia hind

Punk film kodanikuühiskonnast / Artur Talvik, Peeter Vihma, Jaan Tootsen ; intervjueerinud Andrei Liimets

Index Scriptorium Estoniae

Talvik, Artur, 1964-

2013-01-01

Tallinna Uue Maailma kogukonnast rääkivast režissöör Jaan Tootseni ja produtsent Jaak Kilmi dokumentaalfilmist "Uus Maailm". Arutlus teemal, milline on kohaliku kogukonna ja milline riiklike ning kohalike institutsioonide roll paikkonna elu suunamisel ja koordineerimisel, nende omavaheline mõju

Tagurpidi pööratud poliitika / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2009-01-01

Autor näeb vastuolu seoses vaidlusega kaitseväelaste õiguse üle määrata enda hukkumishüvitise saaja: konservatiivse IRL-i minister Jaak Aaviksoo kaitseb sõdurite valikuvabadust ning liberaalist Reformierakonna minister Jürgen Ligi tahaks sõdurite eest otsustada

Ilves lennutati käepigistuseks hiiglaslikule sõjalaevale / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2007-01-01

President Toomas Hendrik Ilves, Riigikogu esimees Ene Ergma, kaitseväe juht Ants Laaneots, kaitseminister Jaak Aaviksoo ja mitu parlamendiliiget külastasid Vahemeres seilavat maailma esimest tuumajõu abil liikuvat lennukikandjat USS Enterprise. Vabariigi Presidendi visiit Ameerika Ühendriikide sõjalaevastiku lennukikandjale USS Enterprise

Õiguskantsleri arvates on peaminister rikkunud põhiseadust / Mati Määrits

Index Scriptorium Estoniae

Määrits, Mati, 1958-

1994-01-01

Eerik-Juhan Truuväli vastas Riigikogu liikme Jüri E. Põllu arupärimisele peaminister Mart Laari poolt 'Finest Hotel Groupi' laenu garanteerimise kohta ja K. Jaak Roosaare arupärimisele presidendi poolt ministrite vahetuse kinnitamata jätmise kohta, 21. veebruar 1994

Rüütel nimetas ametisse neli suursaadikut

Index Scriptorium Estoniae

2006-01-01

President Arnold Rüütel nimetas Jaak Jõerüüdi suursaadikuks Lätis, Mart Tarmaku suursaadikuks Portugalis, Aino Leppik von Wireni suursaadikuks Iisraelis ja Sander Soone suursaadikuks Lääne-Euroopa Liidu ning Euroopa Liidu poliitika- ja julgeolekukomitee juures Brüsselis. Allk.: BNS

Hiirele vesi peale / Timo Diener

Index Scriptorium Estoniae

Diener, Timo

2006-01-01

Animakomöödia "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : eestikeelse dublaazhi režissöör Janno Põldma : rotipoiss Roddy rolli dubleerija Jaak Prints : Ameerika Ühendriigid - Suurbritannia 2006 (stuudiod DreamWorks ja Aardman)

Kempsupotist alla lastud hiir räägib eesti keelt / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2006-01-01

Animakomöödia "Vesi peale" ("Flushed Away") : režissöörid David Bowers, Sam Fell : eestikeelse dublaazhi režissöör Janno Põldma : rotipoiss Roddy rolli dubleerija Jaak Prints : Ameerika Ühendriigid - Suurbritannia 2006 (stuudiod DreamWorks ja Aardman)

Riigijuhtide riskialdis õhulend / Oliver Rand

Index Scriptorium Estoniae

Rand, Oliver, 1971-

2007-01-01

President Toomas Hendrik Ilves, Riigikogu esimees Ene Ergma, kaitseminister Jaak Aaviksoo, kaitseväe juhataja Ants Laaneots, Riigikogu riigikaitsekomisjoni esimees Mati Raidma koos kaaskonnaga lendasid USA lennukikandjale USS Enterprise ühes lennukis. Riigi võtmeisikute üheskoos reisimisega kaasnevatest turvariskidest. Vt. samas: Mujal karmimad meetmed

The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial

Science.gov (United States)

Marks, David I.; Moorman, Anthony V.; Chilton, Lucy; Paietta, Elisabeth; Enshaie, Amir; DeWald, Gordon; Harrison, Christine J.; Fielding, Adele K.; Foroni, Letizia; Goldstone, Anthony H.; Litzow, Mark R.; Luger, Selina M.; McMillan, Andrew K.; Racevskis, Janis; Rowe, Jacob M.; Tallman, Martin S.; Wiernik, Peter; Lazarus, Hillard M.

2013-01-01

The biology and outcome of adult t(4;11)(q21;q23)/MLL-AFF1 acute lymphoblastic leukemia are poorly understood. We describe the outcome and delineate prognostic factors and optimal post-remission therapy in 85 consecutive patients (median age 38 years) treated uniformly in the prospective trial UKALLXII/ECOG2993. The immunophenotype of this leukemia was pro-B (CD10NEG). Immaturity was further suggested by high expression of the stem-cell antigens, CD133 and CD135, although CD34 expression was significantly lower than in t(4;11)-negative patients. Complete remission was achieved in 77 (93%) patients but only 35% survived 5 years (95% CI: 25–45%); the relapse rate was 45% (95% CI: 33–58%). Thirty-one patients underwent allogeneic transplantation in first remission (15 sibling donors and 16 unrelated donors): with 5-year survival rates of 56% and 67% respectively, only 2/31 patients relapsed. This compares with a 24% survival rate and 59% relapse rate in 46 patients who received post-remission chemotherapy. A major determinant of outcome was age with 71% of patients aged <25 years surviving. Younger patients had lower relapse rates (19%) but most received allografts in first complete remission. In conclusion, multivariate analysis did not demonstrate an advantage of allografting over chemotherapy but only five younger patients received chemotherapy. Prospective trials are required to determine whether poor outcomes in older patients can be improved by reduced-intensity conditioning allografts. NCT00002514 www.clinicaltrials.gov PMID:23349309

"Su mõte on see, mida elad" : vanadus / Kaire Nurk

Index Scriptorium Estoniae

Nurk, Kaire, 1960-

2005-01-01

Reet Varblase kuraatoriprojektist "Homo grandis natu" Tallinna Kunstihoones kuni 15. V. Tallinna Kunstikooli õpilaste (õpetaja Katrin Tukmann), Katarzyna Kozyra, Eveli Variku, Marge Monko, Piia Ruberi & Doris Kareva ja Mare Mikofi töödest, Tallinna Ülikooli audiovisuaalkunsti osakonnas tehtud filmidest (Elen Lotman, Jaak Kilmi, Kalev Hiller)

"Keisri hull" on viimast korda laval

Index Scriptorium Estoniae

2010-01-01

Neli hooaega Ugala repertuaaris olnud Jaan Krossi romaani põhjal lavastatud draama "Keisri hull" etendub viimast korda 10. veebruaril. Viimane etendus on pühendatud Jaan Krossi 90. sünniaastapäevale, mis on 19. veebruaril. Lavastajad Peeter Tammearu ja Jaak Allik. Peaosas Peeter Tammearu

ETV ekraanigraafika on Euroopa parimate seas / René Vilbre

Index Scriptorium Estoniae

Vilbre, René, 1970-

2011-01-01

Euroopa avalik-õiguslikle telejaamade konkurentsis valiti ETV ekraanigraafika viie parima hulka. Finaali pääses ETV kahes kategoorias - "Best design package" ja "Best use of audio". Intervjuu vaheklippide autori René Vilbrega. Võttemeeskonda kuulusid veel toimetaja Anu Välba, operaatorid Kristjan-Jaak Nuudi ja Ergo Treier

Külanäitemäng üllatas tenori ja kooriga / Liisi Seil

Index Scriptorium Estoniae

Seil, Liisi, 1971-

2009-01-01

17.-19. juulini toimus Lilli külas 4. Nava lava festival. Loeti luulet ja mängiti Jaak Kõdari kirjutatud mulgikeelset näitemängu "Kõik läheb mööda" ning lasteetendust "Hundi ja Rebase lend lõunanabale". Mõlemad lavastas Silvia Soro

Hea vaistuga miljardiliigutaja Steve Jurvetson / Lauri Levo

Index Scriptorium Estoniae

Levo, Lauri

2005-01-01

Ilmunud ka: Life in Estonia 2005/06, Winter, lk. 24-27. Riskiinvesteerimisfirma Draper, Fisher, Jurvetson (DFJ) üks omanikke Steve Jurvetson tutvustab oma tüüpilist tööpäeva, haridusteed ja hobisid. Kommenteerib AS-i IT Grupp asutaja ja tuumikinvestor Jaak Ennuste

Eestil odava tööjõu eelis kadunud / Liis Kängsepp

Index Scriptorium Estoniae

Kängsepp, Liis, 1981-

2005-01-01

Database Central Europe'i tehtud tööjõu maksumuse uuringu järgi on tööjõukulu Eestis tunduvalt suurem kui Lätis, Leedus ning mitmes Ida-Euroopa riigis. Diagrammid. Kommenteerivad: Peep Siimon, Taavi Veskimägi, Jaak Leimann ja Ilmar Petersen

Eesti funktsionalismi näitus Jyväskyläs / Karin Hallas-Murula

Index Scriptorium Estoniae

Hallas-Murula, Karin, 1957-

2002-01-01

6. VIII-15. IX Alvar Aalto muuseumis Eesti Arhitekuurimuuseumi näitus "Funktsionalism Eestis". Eksponeeritakse 1930. aastate originaalprojekte, digitaliseeritud ajaloolisi fotosid ning makette. Näituse ja kataloogi on koostanud Karin Hallas-Murula, näituse kujundanud Peeter Mauer, kataloogi kujundanud Jaanus Tamme ja Jaak Peep (Tank)

Äpardunud sambameistrid said viimaks hundipassi / Urmas Jaagant, Tuuli Aug ; kommenteerinud Rainer Sternfeld

Index Scriptorium Estoniae

Jaagant, Urmas

2009-01-01

Tšehhi firma Sans Souci ei suutnud Vabadussõja võidusamba ristiosa valgustust rahuldaval määral tööle saada. Uue valguslahenduse leidmiseks on kaitseminister Jaak Aaviksoo palunud algatada riigihanke. Vabadussamba autori Rainer Sternfeldi arvamus tšehhide kehva töö kohta

Vanemuise sünd. Lisandusi eesti pseudomütoloogia ajaloole / Aivar Põldvee

Index Scriptorium Estoniae

Põldvee, Aivar, 1962-

2013-01-01

Seni vähe tähelepanu leidnud tahkudest Vanemuise sünniloos. Kirstian Jaak Petersoni ja Friedrich Robert Faehlmanni Vanemuise käsitlustest. Eelloona vajalikest Thomas Hiärne ja Garlieb Helwig Merkeli muinasloo käsitlustest. Eestlaste ja soomlaste sugulusest ja ühismütoloogiast

Linnaruum - kas ainult arhitektuur? / Mari-Liis Tammi-Kelder

Index Scriptorium Estoniae

Tammi-Kelder, Mari-Liis

2004-01-01

25. IV Tallinna Õpetajate Majas Eesti Kujurite Ühenduse seminar, mis keskendub monumentaalskulptuurile kaasaegses linnaruumis. Esinevad Bernard Gerboud Pariisist, Pekka Jylhä Soomest, Kristaps Gulbis ja Irena Buzinska Lätist, Jüri Soolep, Triin Ojari, Rael Artel, Jaan Elken ja Aili Vahtrapuu. Seminari juhatab Jaak Soans

Koole hakkavad haldama riiulifirmad / Toivo Tänavsuu, Vallo Toomet

Index Scriptorium Estoniae

Tänavsuu, Toivo

2006-01-01

Kümme Tallinna kooli antakse 30 aastaks erafirmade renoveerida ja hallata. 32. keskkooli majandusjuhi Ants Ivaski, Kalev REC juhatuse liikme Peeter Lillestiku, U. S. Investi juhatuse liikme Tarmo Tomaki, RKAS-i juhi Jaak Saarniidu seisukohti. Vt. samas intervjuud Kaia Jäppineniga. Lisa: Rendisumma erineb mitu korda

Täna selgub aasta film 2005

Index Scriptorium Estoniae

2006-01-01

Eesti Filmiajakirjanike Ühing kuulutab välja Neitsi Maali filmiauhinna võitja. Nominendid on : "Afganistani armid" (rezh. Ivar Heinmaa), "Kuum külm sõda : Haukka grupp" (rezh. Rene Vilbre), "Kohtumine tundmatuga" (rezh. Jaak Kilmi), "Libahundi needus" (rezh. Rainer Sarnet), "Mees animatsioonist" (rezh. Hardi Volmer)

Effect of Aqueous Moringa Oleifera (Lam Leaf Extracts on Growth Performance and Carcass Characteristics of Hubbard Broiler Chicken

Directory of Open Access Journals (Sweden)

OJ Alabi

Full Text Available ABSTRACT Two hundred and forty day old broiler chicks were used to investigate the effect of aqueous Moringa oleifera leaf extracts (AMOLE on growth performance and carcass characteristics of broiler chicken. The birds were randomly allocated into six treatments with four replicates, and each replicate containing 10 broiler chicks; the CRD was used. The treatments contained AMOLE0+ (positive control with antibiotic treatment, AMOLE0- (negative control with ordinary water, AMOLE60 (60 ml/l, AMOLE90 (90 ml/l, AMOLE120 (120 ml/l and AMOLE150 (150 ml/l inclusion levels of AMOLE, respectively. Birds on positive control had the highest final body weight and growth rate (2392.00 g and 53.61 g respectively and the ones on 150 ml/l of AMOLE had the least (2042.00 g and 45.37 g respectively. Results of feed intake showed that birds on positive control had the highest (84.70 g and the ones on 90 ml/litre of AMOLE had the lowest (73.19 g; while the results of feed conversion ratio indicated that birds on AMOLE90 and AMOLE120 performed better than the positive control treatment. Birds on the AMOLE had similar dressing percentages though that of positive control was highest (94.93 %; while those on AMOLE60 and AMOLE150 had the highest large intestine and lung weights respectively. Aqueous Moringa oleifera leaf extract can be included up to 90 ml/litre in the drinking water of broiler chicken for reduced feed intake (12.83 % and improved feed conversion efficiency (9.11 thus, AMOLE can be used to replace synthetic antibiotics as growth promoter.

Seleção de Fungicidas para Controle de Oídio em Eucalipto Selection of Fungicides for Control of Eucalypt Powdery Mildew

Directory of Open Access Journals (Sweden)

Rafaela Mazur Bizi

2011-03-01

Full Text Available

Substitusi Medium Sintetik dengan Pupuk Daun, Air Kelapa dan Ekstrak Nabati pada Subkultur Anggrek Cattleya pastoral Innocence secara In Vitro

Directory of Open Access Journals (Sweden)

Etty Handayani

2014-08-01

Full Text Available A research was perfomed to find the proper of coconut water and natural ekstracts combined with Hyponex medium that compared with Vacin & Went medium. This research has been done at Tissue Culture Laboratory, Agricultural Faculty, Universitas Muhammadiyah Yogyakarta. The method of this research was arranged in Randomized Complete Design with 9 treatments and 8 replications. The treatments were VW + NAA 0,5 ppm + BAP 3 ppm, green Hyponex 3 g/l, green Hyponex 3 g/l + bean sprouts 150 g/l, green Hyponex 3 g/l + tomatoes 150 ml/l, green Hyponex 3 g/l + avocado 150 g/l, red Hyponex 3 g/l, red Hyponex 3 g/l + bean sprouts 150 g/l, red Hyponex 3 g/l + tomatoes 150 ml/l, red Hyponex 3 g/l + avocado 150 g/l. The each of Hyponex mediums were given with bananas 150 g/l and coconut water 150 ml/l. The result of this research showed that Hyponex mediums combined with natural ekstract was not signicicantly with Vacin & Went medium to high and shoot growth. Red Hyponex medium 3 g/l combined bananas 150 g/l and coconut water 150 ml/l resulted the best high, leaf and shoot in tissue culture Cattleya pastoral innocence orchid.

ABALONE (HALIOTIS SQUAMATA ANESTHESIA WITH ETHANOL ON GRADING PROCESS

Directory of Open Access Journals (Sweden)

Fanni N.A.

2018-02-01

Full Text Available An abalone is a group of marine molluscs that have high economic value. To increase abalone production, such cultivation needs to be done considering that abalone production still dominating. However, there are still obstacles in the cultivation which is the high mortality rates on the grading process of juvenile abalone. The fatality occurs due to the traditional grading process by gouging abalone to separate abalone that is attached to the substrate. The use of ethanol as an anesthetic material is expected to minimize the mortality and increase the survival rate of abalone. In this study, the use of ethanol by 30 ml/L as an anesthetic material can separate the abalone from its substrate 447.67 seconds faster than the dose of 10 ml/L. However, the 30 ml/L dose also showed the lowest survival rate of 86.67%. The best recovery test is at 10 ml/L with the fastest recovery time of 143.33 seconds which has a high survival rate of 98.33%. The success of anesthesia by using ethanol in this study can also be done in the grading process of abalone seed and can minimize death due to the traditional grading process.

Tampere ja Unt / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2003-01-01

Ülevaade 5.-9. märtsini toimunud Tampere 33. lühifilmide festivalist. Riho Undi nukufilm "Hing sees" sai animafilmide žürii diplomi. Võistluskavas minifilmide seas osales ka Priit Pärna joonislaast "Liiga hilja" ("2 Late")

Kliendihaldus toob efektiivsuse / Jaak Ennuste

Index Scriptorium Estoniae

Ennuste, Jaak

2003-01-01

Kliendihaldustarkvara (CRM) efektiivsus sõltub selle kasutamise ulatusest organisatsioonis. Kliendihaldustarkvara turuliider SalesLogix. Põhilised probleemid kliendisuhtluses. Joonis: Kliendiinfo liikumise skeem

Arvo Järvet / Jaak Jaagus

Index Scriptorium Estoniae

Jaagus, Jaak, 1956-

2005-01-01

23. aprillil 2004. a. kaitses Arvo Järvet Tartu Ülikoolis doktoritööd "Influence of hydrological factors and human impact on the ecological state of shallow Lake Võrtsjärv in Estonia" ("Hüdroloogiliste tegurite ja inimtegevuse mõju madala järve ökoseisundi kujunemisele Võrtsjärve näitel")

Hirm valitseb Marimaad / Jaak Prozes

Index Scriptorium Estoniae

Prozes, Jaak, 1965-

2005-01-01

Fenno-Ugria hõimukeskuse juhataja sõnul toimub Marimaal arveteõiendamine nendega, kes toetasid presidendivalimiste kampaanias Leonid Markelovi vastaskandidaati, samuti ei sallita neid, kelle arvamus presidendi omaga kokku ei lange. Vägivallajuhtumitest

Saladus on tagasi / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2002-01-01

Kogupere ulmefilm "E.T. - sõber kaugelt" ("E.T. The Extra-Terrestrial") : režissöör Steven Spielberg : Ameerika Ühendriigid 1982. Restaureeritud ja paari omal ajal välja jäetud stseeniga täiendatud uusversioon

Väljavalituse tunne / Jaak Kilmi

Index Scriptorium Estoniae

Kilmi, Jaak, 1973-

2005-01-01

Lühihinnang IX Pimedate Ööde Filmifestivali mängufilmidele - "Garpastum" : režissöör Aleksei German jun : Venemaa 2005, "Kohe paradiisi" ("Paradise Now") : režissöör Hany Abu-Assad : Holland - Saksamaa - Prantsusmaa 2005, "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005, "Kolmel ajal" ("Three Times") : režissöör Hou Hsiao-hsien : Taiwan - Hiina 2005

Lühifilmid internetis / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2000-01-01

Mika Salmi internetifirma Atom Films, kes on 8.-12. märtsini toimuva 30. Tampere rahvusvahelise lühifilmifestivali üks sponsoreid, tegeleb lühifilmide tutvustamise ja turustamisega interneti kaudu

Palmioks kriitilisele realismile / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Cannes'i filmifestivali võitjad. Kuldse Palmioksa võitis Ken Loachi mängufilm "Tuul, mis sasib odrapõldu" ("The Wind That Shakes the Barley"), Grand Prix' sai prantslase Bruno Dumonti film "Flandria" ("Flandres"), parim režissöör oli Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja auhinna sai grupp näitlejannasid Pedro Almodovari filmist "Tagasipöördumine" ("Volver") ja meesnäitleja auhinna sai samuti grupp näitlejaid prantsuse filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi filmile "Punane tänav" ("Red Road")

Hetki suvisest teatriuputusest / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2008-01-01

Lühidalt suvelavastustest "Wargamäe Wabariik", "Ruja", "Keiserlik kokk", "Vahepeatus", "Pikk päevatee kaob öösse", "Ma olen iseenda naine", "Džinnimäng", "Klaver", "Romeo ja Julia", "Rasputin", "Ohver", "Ernesaks ja Oamats"

Animafilminduse algusotsast 1 / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

Maailma esimestest animafilmidest : Albert Smith'i "The Humpty Dumty Circus" (USA, 1898), esimene joonisfilm "Naljakate nägude humoorikad ilmed" (Humorous Phases of Funny Faces") - looja Stuart Blackton (USA, 1906). Esimese joonisseriaali kangelase Fantosche'i lõi Prantsusmaal 1909.a. Emile Cohl

Vereplekid punasel vaibal / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak, 1955-

2009-01-01

62. Cannes'i festivali filmidest : Pedro Almodovari "Katkirebitud embused" ("Los abrazos rotos"), Lars von Trieri "Antikristus" ("Antichrist"), Quentin Tarantino "Vääritud tõprad" ("Inglourious Basterds")

Perm neelas komid / Jaak Prozes

Index Scriptorium Estoniae

Prozes, Jaak, 1965-

2004-01-01

Permikomi autonoomse ringkonna ühinemisest Permi oblastiga. Autori arvates viitab ühinemisprotsess ühemõtteliselt uuele kujunevale Venemaa rahvuspoliitikale, etniliste eripärade tasalülitamisele

Voitka-filmi esilinastus / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2004-01-01

Inglase Daniel Elliotti Eestis tehtud lühimängufilm "Fender Bender" sai Tampere lühifilmide festivalil maineka Prix UIP (United International Pictures) Tampere auhinna. Samal festivalil toimus Pekka Lehto tõsielufilmi "V.O.I.T.K.A. - Metsa vennad" maailmaesilinastus. Erkki Määttäneni "Järveehitaja" portreteeris Leigo järvemuusikakontsertide korraldajat Tõnu Tamme

Korruptsiooni bioloogilised juured / Jaak Rebane

Index Scriptorium Estoniae

Rebane, Jaak

1999-01-01

Kuritarvitusele aitavad viia inimese teatud omadused, nagu egoism, piiratus, ahnus, jultumus, tarbimismentaliteet, tõusiklikkus. Korrumptantsaab varumistungi ajel ebaeetilisest käitumisest hoopis positiivse emotsiooni

Žanr : suvelavastus? / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2007-01-01

Kahekümnest suvisest teatriõhtust: Carlo Gozzi "Ronk" Tallinna Linnateatri lavaaugus (lavastaja Elmo Nüganen), Komöödiateatri suvetuuri lavastus "Elu parim puhkus" (lavastaja Ago-Endrik Kerge), muusikal "Tutvumiskuulutus" (lavastaja Mait Malmsten), Bernard Kangermanni laulumäng "Naabri Mari" (lavastaja Margus Vaher) ja Mara Zalite "Sirelikassid" (lavastaja Peeter Tammearu) Ugalas, Paul Barzi komöödia "Võimalik kohtumine" (lavastaja Raivo Trass) Vanemuise teatri suvelavastus Muhumaal Pädaste mõisas, muusikaline estraadietendus "Tähtede sadu", Endla "Tsirkus!!!" Paikuse-Reiu vabaõhulaval (autor ja lavastaja Tiit Palu), Andrus Kivirähki näidend "Uljas Neitsi" Laulasmaa Resort' rannametsas (lavastaja Taavi Teplenkov), Marti Kivastik "Eesti asi" (lavastaja Ingomar Vihmar) MTÜ Ühendus R.A.A.A.M. Viinistu kunstimuuseumi vabaõhulaval, Emajõe Suveteatri suvelavastus "Jumalaema kiriku kellamees" Victor Hugo romaani järgi (lavastaja Andres Dvinjaninov), "Muna EÜE ehk Viimane kava" (autor Lauri Vahtre, lavastaja Andrus Vaarik) Suure Munamäe vabaõhulaval, Aino Kalda "Reigi õpetaja" Kuressaares (lavastaja ja dramatiseerija Aare Toikka), Vana Baskini Teateris Pierre Chesnot "Kes aevastas?" (lavastaja Eino Baskin), Eduard Vilde romaani "Prohvet Maltsvet" ja vene kirjaniku Viktor Pelevini romaani aineil sündinud lavastus "Proffet" Albu vallas Kukenoosi rehealuses (lavastaja Mart Koldits), Enn Vetemaa "Roosiaed" Raasiku vallas Kiviloo mõisas (lavastaja Eva Klemets), Jim Ashilevi "Portselansuits" (lavastaja Lauri Lagle) Eesti Teatriliidu saalis, Andres Keili "Rooside sõda" Leigo Järveteatris (lavastaja Tõnu Lensment), Võru Teatriateljee suvelavastus Madis Kõivu "Castrozza ehk illusionist" (lavastaja Taago Tubin), Villu Tamme "Haned võlgu" (lavastaja ja kunstnik Jaanika Juhanson) Teatrilabor Von Krahli teatris

Meelelahutus on meelelahutus / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

17. mail esilinastus Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard). Filmi linastuse järel toimunud pressikonverentsist, kus olid kohal nii lavastaja kui staarid ja rekordarv ajakirjanikke

Esimene avalik filmiseanss / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

Thomas Alva Edisoni kinetoskoobi patendi omandamise ebaseseaduslikkusest : Gordon Hendricks oma raamatus "Edisoni filmimüüt" tõestavat, et autorlus pidanuks kuuluma William Kennedy Laurie Dicksonile (1860-1935)

Lisandusi postkolonialismi diskussioonile / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2011-01-01

Et Eesti oli Nõukogude okupatsiooni koloniseerimise ohver, tuleks eesti kunsti ajaloo uurimisel lähtuda postkolonialistlikule teooriale omastest lähenemisviisidest ja mõistetest, mis võimaldaksid juba tuntud tõsiasju uutmoodi tõlgendada ning selgitada meie ajalugu ja kultuuri rahvusvahelisele üldsusele. Kolonialismi tunnustest ja levikust Ida-Euroopas 20. sajandil ning mõjudest eesti kunstile, postkolonialismi teooriast ja selle rakendustest

Use of Sodium Hypochlorite for the Control of Bakanae Disease in Rice

OpenAIRE

Dong Bum Shin; Jaeduk Goh; Bong Choon Lee; In Jeong Kang; Hang-Won Kang

2014-01-01

For application of sodium hypochlorite as a seed disinfectant to the control of bakanae disease caused by Gibberella fujikuroi in rice, we investigated the effects of sodium hypochlorite for antifungal activity, eliminating fungus from seeds and reducing disease occurrence in vitro and greenhouse. The viability of the pathogen was significantly reduced at 80 ml/l concentration of sodium hypochlorite, and the pathogens did not grow at over 100 ml/l concentration of sodium hypochlor...

Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

Index Scriptorium Estoniae

Schwidtal, Michael

2001-01-01

3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

Ökokunst Viljandi "Kiriküüdil" / Johannes Saar

Index Scriptorium Estoniae

Saar, Johannes, 1965-

2002-01-01

Lõppes seitsmes ökoteemaline "Kiriküüt". Ürituse organiseerijate eesotsas on pikemalt olnud Tiiu Männiste ja Mari Sobolev. Jakobsoni kuju juures kandsid kirikuõpetaja Mart Salumäe ja "Ugala" direktor Jaak Allik ette rühmituse VSN performance'i "Mulgi näide". Ökoloogiast

Piimatööstused kukkusid kahjumisse / Aare Annus ; interv. Silja Lättemäe

Index Scriptorium Estoniae

Annus, Aare

2005-01-01

Tallinna Piimatööstuse AS-i nõukogu esimees Aare Annus Eesti piimatööstuste raskest olukorrast seoses toorpiima kõrge kokkuostuhinnaga. Vt. ka: Kas saite piimahinnast kõva kasumit? Küsimusele vastavad Järvamaa talunik Arvo Kuutok ja Põlva Agro OÜ nõukogu esimees Jaak Hinrikus

Rasedad mehed Eesti tõsist dokumentalistikat ei ohusta / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2007-01-01

Tartus Maailmafilmi festivali raames toimunud noorte loojate ümarlauast eesti dokumentalistika probleemidest (juhatas Anders Härm, osalesid Jaak Kilmi, Andres Maimik, Rain Tolk, Urmas E. Liiv, Eeva Kesküla). Lühidalt ka festivalil linastunud Liivo Niglase ja Frode Storaasi dokumentaalfilmist vihma loitsimisest Aafrikas "Vihmategemine" (Eesti - Norra - Mosambiik 2007)

Eesti puidufirma laieneb Sri Lankale / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2004-01-01

Eesti puidufirma Hapa Group alustab tootmist Sri Lankal, lootes suurendada kasumit odava toorme ja tööjõu kasutamise läbi. Lisa: Mõned faktid Hapa Groupi kohta. Diagramm: Tööjõud Sri Lankal 10 korda odavam. Kommenteerivad August Kull, Jaak Leimann, Ilmar Petersen ja Alar Kolk

Uue kunsti tegijad pakuvad head maali / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2006-01-01

Pärnuga seotud või Pärnust pärit kunstnike uuem looming näitusel "Looja, loo lugu, loo lugu, looja, loo..." Pärnu Uue Kunsti Muuseumis. Osalevad Toomas Kuusing, Siram, Bruno Sõmeri, Anonymous Boh, Mark Soosaar, Jaak Visnap, Mila Balti, Kadri Alesmaa, Bille Neeve. Kuraator Andrus Joonas

Adamson-Eric 100 : XX sajandi kunsti- ja kultuurilugu ühe inimsaatuse kaudu / Ülle Kruus

Index Scriptorium Estoniae

Kruus, Ülle

2002-01-01

Näitus "Adamson-Eric 100" Eesti Kunstimuuseumi Rüütelkonna hoones ja Adamson-Ericu muuseumis. Koostajad Ülle Kruus, Kersti Koll, Hanno Soans, kujundajad Leonhard Lapin (EKM), Jaak Soans (Adamson-Ericu muuseum). Adamson-Ericu teosed väljaspool Eestit ja Eestisse tagasi jõudnud tööd

LEADER Eestis - mis toimub, mis toimumas? / Ave Bremse

Index Scriptorium Estoniae

Bremse, Ave

2008-01-01

LEADER-programmi rakendumise edukusest Eestis. Vt. samas: 1. Kuidas teie kohalikul tegevusgrupil läheb? 2. Mida uut on toonud LEADER teie piirkonda? Küsimustele vastavad: Aili Ilves, Hardi Murula, Merle Adams, Sille Tars, Jaak Vitsur, Mercedes Merimaa ja Piia Kärssin. Lisa: Statistikat ja infot kohalike tegevusgruppide kohta

Alates 13. XII on Vaala galeriis avatud "Talvesalong"

Index Scriptorium Estoniae

2004-01-01

Väljas on Ellinor Aiki, Valdur Ohaka, Herman Talviku, Jaak Arro, Raoul Kurvitza, Andres Toltsi, Laurentsiuse, Lembit Saartsi, Rait Rosina, Merike Estna, Maarit Murka ning Aleksandr Breneri ja Barbara Schurzi tööd. 17. XII Anna Litvinova, Ilmar Kruusamäe ja Lembit Sarapuu ühised maaliseansid

Drama Russkogo teatra : posledni akt / Jaanus Kukk, Jevgeni Golikov ; interv. Boris Tuch

Index Scriptorium Estoniae

Kukk, Jaanus

2008-01-01

Vene Teatri kunstiline juht Mihhail Tshumatshenko lahkus ametist. Vene teatri olukorrast räägivad ja avaldavad oma arvamust ka Aivar Mägi, Jaak Allik, Laine Jänes, Artjom Garejev, Aleksandr Ivashkevitsh, Julia Jablonskaja. Lühendatult on avaldatud Ugala teatri lavastaja Peeter Tammearu avalik pöördumine

Effect of Formic Acid on In Vitro Ruminal Fermentation and Methane Emission

Directory of Open Access Journals (Sweden)

Kanber Kara

2015-10-01

Full Text Available In this study, it was aimed to investigate the effects of formic acid on the in vitro methane production and in vitro ruminal fermentation of alfalfa hay. Effect of 0.0 (control group: YF0, 0.1, 0.2, 0.3, 0.4 and 0.5 ml/L (experimental groups: YF1, YF2, YF3, YF4, and YF5 respectively formic acid (Amasil85-liquid addition to rumen fluid on ruminal fermentation parameters of alfalfa hay were determined by using in vitro gas production techniques. Methane production of in vitro incubation increased (to about 20% with addition of linearly increased formic acid. Linearly increased levels of formic acid addition to rumen fluid has significantly changed the production of in vitro total gas production, metabolic energy (ME and organic matter digestibility (OMD at linear, quadratic and cubic. The addition of 0.1 ml/L and 0.2 ml/L formic acid to rumen fluid significantly decreased in vitro total gas production, ME and OMD however addition of 0.3 ml/L and 0.4 ml/L formic acid was not changed in vitro gas production, ME and OMD levels and 0.5 ml/L formic acid was significantly increased all these parameters. Ruminal pH was not changed by addition of formic acid. Formic acid is a safe feed additive because of its properties antibacterial and flavorings and also is used as a fermentation promoter in silage. In this study it has been observed that all doses of formic acid increased in vitro enteric methane production and low doses decreased in vitro total gas production, ME and OMD and high doses have increased all these parameters. High doses have a positive effect on ME and OMD; however formic acid should be used at limited levels in diets due to the negative effect of increasing greenhouse gases. The effect of formic acid addition to the feed raw matter and rations of all livestock would be beneficial to investigate in terms of digestive system parameters and global warming, further in vitro and in vivo studies.

Estandarización de un medio de cultivo a partir de fuentes agroindustriales para la multiplicación de Azospirillum brasilense

Directory of Open Access Journals (Sweden)

Diego Rivera

2012-07-01

Full Text Available The Plackett-Burman statistical design was initially applied for Screening the most important nutritional variables (four carbon sources, two nitrogen sources, K2 HPO4 y MgSO4 and a trace elements solution affecting microorganism biomass production. Subsequently, a optimising the process by applied a BoxBehnken design for the most important factors tree. The results showed that biomass (UFC/mL production was strongly affected by nutritional and physico conditions of culture medium. The highest yield was obtained in the following conditions: 3g/L sucrose, 6,75 mL/L molasses, 0,77 mL/L glycerol, 14,42 mL/L soybean hydrolyzate, 0,848 g/L yeast hidrolyzate, 0,25 g/L K2 HPO4 , ⅗ aeration and shaking at 120 rpm 26 hours total fermentation time during which 1 x 109 UFC/mL were obtained.

Et ainult inimene mõtleb? Ajab rotigi naerma! / Mati Soomre

Index Scriptorium Estoniae

Soomre, Mati, 1944-2015

2008-01-01

USA Bowling Green State'i ülikooli emeriitprofessor, Tartu Ülikooli audoktor professor Jaak Panksepp väidab, et rotid naeravad ning USA Georgia Ülikooli teadlased Allison Foote ja Jonathon Crystal leidsid, et ka rotil on metakognitsioon - võime oma mõtlemist mõelda. Vt. ka lk. 35: Rott & meie

Armastus ja anarhia / J[aan] R[uus

Index Scriptorium Estoniae

J. R.

1993-01-01

Helsingi filmifestivali "Armastus ja anarhia" mängufilmid "Nekromantik I" (1987) ja "Nekromantik II" (1991), režissöör Jörg Buttgereit ja "Trellimõrtsukas" (1979), režissöör Abel Ferrara, Tallinna kinos "Eha". Arvustavad Rainer Sarnet, Jaak Kilmi, Marko Raat ja J. R. (Jaan Ruus)

Algab sari "Kontserdid Kunstihoones". Bachi "Jõuluoratoorium" Jaani kirikutes

Index Scriptorium Estoniae

2008-01-01

Soprani Kersti-Ala Murri ja akordionisti Jaak Lutsoja kontserdist Eesti Interpreetide Liidu korraldatava kontserdisarja "Kontserdid Kunstihoones" raames 21. dets. Tallinna Kunstihoone suures saalis. J. S. Bachi "Jõuluoratooriumi" ettekandest 28. dets. Tartu Jaani kirikus ja 29. dets. Tallinna Jaani kirikus (esinevad kammerkoor Voices Musicales solistidega ja Corelli Barokkorkester, dirigent Risto Joost)

"Keisri hull" pürib taas filmiks

Index Scriptorium Estoniae

2008-01-01

Eesti Filmi Sihtasutus otsustas anda arendustoetust mängufilmidele "Keisri hull" (režissöör Peeter Simm, arendaja Lege Artis Film), "Rahad ette" (režissöör Jaak Kilmi, arendaja Eetriüksus), "Öölendurid" (režissöör Peeter Urbla, arendaja Exitfilm)

"Karu süda" võistleb Anapa festivalil

Index Scriptorium Estoniae

2002-01-01

Anapas toimub 5.-16. septembrini rahvusvaheline filmifestival "Kinošokk". Žüriisse kuulub ka Peeter Simm. Eestit esindab võistlusprogrammis Arvo Iho "Karu süda". Videofilmide programmis on Rene Vilbre "Armas tuss" ja Mark Soosaare "La Paloma", Jaak Kilmil on kaasas oma kuraatoriprogramm Balti alternatiivsetest lühifilmidest

7. X avati Viljandis Kondase keskuses litograafianäitus

Index Scriptorium Estoniae

2003-01-01

Eesti Litograafiakeskuse korraldatud näitusel tutvustatakse litograafiatehnikat ja selle ajaloolist arengut. Väljas on Pärnus 5.-25. IX Eesti I litograafiasümpoosioni raames toimunud näitustel "Old Stars" ja "Young Generation" eksponeeritud eesti graafikute litotehnikas teosed ning näituse koostajate Jaak Visnapi ja Kadri Alesmaa looming

Arhetüüpse ja shiki kohtumine : ärihoone "Ferrum" Saaremaal Kuressaares = Encounter of Archetypal and Chic : Ferrum Centre in Saaremaa in Kuressaare / Ingrid Lillemägi

Index Scriptorium Estoniae

Lillemägi, Ingrid

2003-01-01

Projekteerija: Alver Trummal Arhitektid. Autorid Andres Alvar, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets. Konstruktor Jaak Juha (Tööstusprojekt). Projekt 2001, valmis 2002. Stiilse ruumi vastuolu seda asustavate poodide kirju kribu-krabu ja juhuslike reklaamplakatitega. I ja II korruse plaan, 5 välis- ja 2 sisevaadet

Noored režissöörid väärtustavad eneseleidmist / Maiju Ingman, Anu Aun ; interv. Karin Klaus

Index Scriptorium Estoniae

Ingman, Maiju

2007-01-01

Pärnus näidatakse noortefilme : soomlanna Maiju Ingmani TÜ lõputööd "Mida iganes, Aleksander" (teekonnafilm, osades Jaak Prints, Arvo Kukumägi) ja Anu Auna lühifilmi "Indigo tuba" (mängivad Mirtel Pohla, Alo Kõrve). Režissöörid oma otsingutest ja filmidest

Kahekordne austusavaldus suurele hilinejale / Margit Urbel

Index Scriptorium Estoniae

Urbel, Margit

2011-01-01

Portreefilmid Lennart Merest: Jaak Lõhmuse (stsenarist ja režissöör) dokumentaalfilmist "Tantsud Linnuteele. Pildistusi Lennart Meri filmirännakutelt" (Estinfilm ja ERR, 2010) ja Arko Okki dokumentaalfilmist "Monoloogid 3D" ("Man Who Lived in Three-Dimensional Time", Acuba Film koostöös Uljana Kim Studio 2007-2011)

Jazz festival offers mellow way to get into festive spirit / Aleksei Gunter

Index Scriptorium Estoniae

Gunter, Aleksei, 1979-

2003-01-01

Aafrika laulja Malia kontserdist Sakala keskuses 9. dets.; Jaak Sooääre ja taani kitarristi Pierre Dorge kontserdist Tallinna kunstihoones 4. dets.; Hedvig Hansoni ja Andre Maakeri kontserdist Niguliste kirikus 11. dets.; ameerika ansambli Gold Company Sextet kontsertidest Tallinnas 14. dets. ja Pärnus 15. dets. festivali Jõulujazz raames

Marilyn Monroe eluloost keisri hullu kannatusteni / Gert Kiiler

Index Scriptorium Estoniae

Kiiler, Gert

2006-01-01

Ugala uut hooaega tutvustavad lavastajad. Jaak Allik ja Peeter Tammearu lavastavad Jaan Krossi romaani "Keisri hull" järgi samanimelise näidendi, Priit Võigemast Igor Bauersma "norway.today", Kristi Teemusk omakirjutatu järgi lastelavastuse "Kes päästab koletise?" ja Kalju Komissarov Eppu Nuotio, Tiina Brännare muusikali "Marilyn"

Millele pöörate eluaseme ostmisel ja üürimisel tähelepanu?

Index Scriptorium Estoniae

2005-01-01

Küsimusele vastavad Brüsselis tööd otsiv Kadri Kuusk, Sampo Panga koolitusosakonna juhataja Külli Meier, finantsinspektsiooni osakonnajuhataja Andre Nõmm, Riigikogu liige Meelis Atonen, Palivere lastekodu juhataja Külle Saar, Helsingis töötav arst Jaak Kiviloog, Narva kooliõpetaja Julia Ivanova, maksu- ja tolliameti peaspetsialist Tiiu Kilk

Estonian living in safest of times / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

Peaminister Andrus Ansip ütles kevadisi riigikaitsekursuseid avades, et tema hinnangul elab Eesti julgeoleku seisukohalt oma ajaloo ilmselt kõige turvalisemat etappi, olles NATO ja Euroopa Liidu liige. Kursuste avamistseremooniast võtsid osa ka kaitseminister Jaak Aaviksoo, välisminister Urmas Paet, siseminister Marko Pomerants ja kaitseväe juhataja kindralleitnant Ants Laaneots

Ähvardus : olümpiamängude teleülekanne jääb ära / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2005-01-01

Riigikogu liige Jaak Allik peab vajalikuks leida ETV-le lisamiljoneid olümpiamängude ja jalgpalli MM-i teleülekanneteks. Riigikogu liikmed Olav Aarna ja Katrin Saks kritiseerisid valitsust, et rahvusringhäälingu arengukava suhtes pole võetud seisukohta. Kultuuriminister Raivo Palmaru arvamusi. Lisa: Ringhäälingureform tulekul

Konkurentsis kolme Eesti tudengi filmid / Maris Balbat

Index Scriptorium Estoniae

Balbat, Maris, 1936-

2003-01-01

PÖFFiga kaasneval tudengifilmide festivalil esindavad Eestit Mart Arjukese ja Kristjan Jaak Nuudi lühimängufilm "Duell"; Kristi Leppiku nukufilm "Narkissos" ja Andres Puustusmaa lühimängufilm "Pärast müra". Lisatud lühiintervjuud Mart Arjukese ja Kristi Leppiku ning žürii liikme Peeter Urblaga

Naturen i den estniska poesin : från animism och panteism till zenbuddhism / Andres Ehin

Index Scriptorium Estoniae

Ehin, Andres, 1940-2011

2001-01-01

Orig.: Loodus eesti luules: animismist ja panteismist kuni zen-buddhismini. Tekstis on rootsikeelseid luulenäiteid järgmiste eesti luuletajate loomingust: Kristjan Jaak Peterson, Karl Eduard Sööt, Ernst Enno, Gustav Suits, Henrik Visnapuu, Villem Ridala, Betti Alver, Uku Masing, Bernard Kangro, Kalju Lepik, Ilmar Laaban, Artur Alliksaar ja Hando Runnel.

Genomic and transcriptome profiling identified both human and HBV genetic variations and their interactions in Chinese hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

Hua Dong

2015-12-01

Full Text Available Interaction between HBV and host genome integrations in hepatocellular carcinoma (HCC development is a complex process and the mechanism is still unclear. Here we described in details the quality controls and data mining of aCGH and transcriptome sequencing data on 50 HCC samples from the Chinese patients, published by Dong et al. (2015 (GEO#: GSE65486. In additional to the HBV-MLL4 integration discovered, we also investigated the genetic aberrations of HBV and host genes as well as their genetic interactions. We reported human genome copy number changes and frequent transcriptome variations (e.g. TP53, CTNNB1 mutation, especially MLL family mutations in this cohort of the patients. For HBV genotype C, we identified a novel linkage disequilibrium region covering HBV replication regulatory elements, including basal core promoter, DR1, epsilon and poly-A regions, which is associated with HBV core antigen over-expression and almost exclusive to HBV-MLL4 integration.

Kuidas raamida merd? / Ell-Maaja Randküla

Index Scriptorium Estoniae

Randküla, Ell-Maaja, 1939-2016

2005-01-01

Korter Tallinnas Pirita teel. Sisekujundus: Ilona Põldme, OÜ Põldme. Ehitaja: OÜ Onix Invest. Olulise osa mööblist kavandas I. Põldme, valmistas OÜ Timbermeister. Elutoas kompositsioon Epp Maria Kokamäe maalist ja Jaak Arro puulõikest. Ilona Põldmest, tema tähtsamad tööd. Ill.: plaan, 19 värv. vaadet

Varjamine: samba salalepingud tõid tšehhidele lisamiljoneid / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2010-01-01

Kaitseminister Jaak Aaviksoo ja Tšehhi klaasifirma sõlmisid 2009. a. lepingu muutmise lepingu koos paljude uute lisadega. Lepingu lisas nõudis kaitseminister kollase tooniga risti ringiosa paneelide väljavahetamist, kuid tookord teatas ministeerium, et paneelid vastavad esialgsel hinnangul kokkulepitule. Ministeeriumi avalike suhete osakonna juhataja Martin Jaško ja vandeadvokaat Martin Tamme selgitusi

Männik ohverdas Aaviksoo

Index Scriptorium Estoniae

2003-01-01

Eesti Telekomi nõukogu otsusest vabastada ametist EMT juhatuse esimees Peep Aaviksoo, uuest kandidaadist Valdo Kalmust ning EMT ja Elioni võimalikust ühinemisest. Diagramm: EMT turuosa libiseb Tele2-le. Vt. samas: EMT lahkuva juhi Peep Aaviksoo avalik kiri. Kommenteerivad Sami Seppänen, Üllar Jaaksoo, Monika Salu, Jaak Aaviksoo, Toomas Tamsar

Kus ta siis ometi on - see Bob Dylan? / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2008-01-01

Todd Haynes'i mängufilm muusik Bob Dylanist "Kus on Bob Dylan?" ("I'm Not There") : laulja alter ego kehastavad Ben Whishaw, Christian Bale, Heath Ledger, Cate Blanchett, Richard Gere, Marcus Carl Franklin : Ameerika Ühendriigid 2007. 4. juunil Saku Suurhallis toimuvast kontserdist. Jaak Johanson, Tõnis Mägi, Riho Sibul, Hannes Varblane ameerika lauljast

Kleenexi ja Tampaxi pojad / Urmas Petti

Index Scriptorium Estoniae

Petti, Urmas, 1965-2016

2013-01-01

Laste ja noorte kasvamisest ja kasvatamisest tänapäeval, nende hakkamasaamisest üha keerulisemaks muutuvas ühiskonnas; autor tsiteerib Jaak Jõerüüti (romaan "Muutlik" 2010) ja kommenteerib argentiina kirjanikku Julio Cortázar'i ja briti kolumnisti võrdlevas usuteaduses Karen Armstrongi (raamat "Jumala ajalugu", orig. "A History of God" 1993)

12. I avati Tallinna Linnagaleriis...

Index Scriptorium Estoniae

2005-01-01

Müncheni Kunstvereini dokumentalistikaprojekt "Es ist schwer das Reale zu berühren". Kuraatorite Soren Grammeli ja Maria Lindi kokkupandud videoarhiivi kuulub 60 kunstniku ligi sada videot. Loetletud 16 skriiningutel osalenud kunstnikku (Eestist Mari Laanemets & Killu Sukmit). Festivalidel on Eestist osalenud veel Mark Raidpere ja Marko Raat. Avamisel kõnelesid Maria Lind ja Jaak Kilmi

Jazz-muusikud tulevad kevadet tooma / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2009-01-01

Pärnus Jazzkaare festivalil esinejatest: norra laulja Solveig Slettahjell 19. aprillil Eliisabeti kirikus, Hedvig Hanson kontserdiga "Rahvaste hällilaulud" 21. apr. Pärnu kontserdimajas, duo Jaak Sooäär - Tuule Kann 22. apr. Pärnu raekojas ja Andy Emleri trio 23. apr. Ammende villas. Jazzkaare festivali ajaloost korraldaja Anne Ermi sõnul

Nad on ärganud ja juba küpsed / Ilmar Raag

Index Scriptorium Estoniae

Raag, Ilmar, 1968-

2000-01-01

Pimedate Ööde Filmifestivalil esilinastusid lühimängufilm "Armas tuss 50 aastat hiljem" : režissöör René Vilbre : peaosades Lembit Eelmäe ja Herta Elviste : Allfilm 2000 ja dokumentaalfilm "Suur õde" : stsenaristid ja režissöörid Jaak Kilmi ja Andres Maimik : In-Ruum 2000

Patarei ja Lennusadama ala planeering = Plan for the Patarei Fort and Lennusadam Port Area

Index Scriptorium Estoniae

2007-01-01

Patarei ja Lennusadama ala mahulise planeerimise rahvusvaheline ideevõistlus 2007. aastal. Võistlustööd "Kolm õuna" (I preemia - Sverre Laanjärv, Ivar Lubjak), "Põhi" (II preemia - Tõnu Laanemäe, Jaak-Adam Looveer, Toomas Paaver, kaasautorid Indrek Järve ja Lauri Saar) ja "Kompass" (III preemia - Ott Kadarik ja Villem Tomiste, AB Kosmos)

Draama 2007. Töörahu / Ene Paaver

Index Scriptorium Estoniae

Paaver, Ene, 1963-

2008-01-01

Ülevaade 2007. aasta eesti draamast. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid: Mart Kivastik "Tõnu võitlused", Mart Kivastik "Eesti asi", Mart Kivastik "Sõdur", Mart Kivastik "Kuninga viimane lahing ja ülikooli algus", Mart Kivastik, "Nokia 3310", Andrus Kivirähk "Voldemar", Andrus Kivirähk "Uljas neitsi", Hendrik Toompere "Kommunisti surm", Andres Ehin "Saatuslik kihlvedu ehk Volquin Varbola all", Jan Rahman "Jõujaam", Jaak Kõdar "Muinassaar", Karl Berg "Teekond valguse riiki", Angela Randmets "Lembelood vanas linnas", Toomas Kall "Tähtede sadu", Lauri Vahtre "Muna EÜE", Urmas Espenberg "Kestvad kiiduavaldused", Kalju Saaber "Koduvõõrad", Indrek Hirv "Pauluse kiriku kellad", Katrin Saukas "Võlg", Heidi Sarapuu "Austatud Riigikogu liikmed!", Heidi Sarapuu "Helisev viis", Heidi Sarapuu "Ankur hiivata", Jakob Karu "Vanaema juures", Jim Ashilevi "Nagu poisid vihma käes", Jim Ashilevi "Portselansuits", Eva Koff "Mirr", Jaak Prints "Karaoke", Kati Murutar "Mina, naine!", Ott Aardam "Börs ja Börsitar", Andrus Kivirähk, Jan Rahman, Contra "Kõrts", Mart Kase "Perekond", Villu Tamme "Haned võlgu"; Tiit Ojasoo ja Ene-Liis Semperi "GEP ehk Gorjatshije estonskije parni"

Kuu kultuurikulgur

Index Scriptorium Estoniae

2008-01-01

Laivüritusest "Punk 2008" Tartus Athena klubis 11. septembril. Briti ansambel Klaxons 6. okt. Tallinnas klubis Hollywood. Moskva laulja Pelageja 5. okt. Tallinna linnahallis ja 7. okt. Jõhvi kontserdimajas. Heategevuskontserdist 14. sept. Tuhalaane kirikumäel (esinevad Tõnis Mägi, Robert Jürjendal, Ain Agan, Andre Maaker, Riho Sibul, Jaak Johanson, Jaak Tuksam jt). Kultuuritehase toetuseks korraldatud kontserdist "Polyymide päev" (esinesid rokkbändid Sõpruse Puiestee, Malena, Pure Mind ja Pilveke). Ooperi "Hullu mehe aias" lavastusest (lavastaja Robert Annus, koreograafia Triin Reemann, dirigent Veronika Portsmuth, lavakujundus ja kostüümide kunstnik Samal Blak Fääri saartelt) 10.-12. septembrini Tallinnas Kultuurikatlas. Kanada ansambli Simple Plan kontserdist 28. okt. Tallinnas klubis Rock Café. Üritustest Viljandi Pärimusmuusika Aidas: 6. sept. esinevad ansambel Paabel+, akordionist Kulno Malva ja DJ Harlet, etendus "Vaterland" 10. sept., Aida muusikud 11. sept., Anu Taul 13. sept. Fernando Stern ja Ethno in Transit 16. septembril. Gruusia ansambli Shin Egari kontsertidest 9. sept. Tartus Genialistide klubis, 10. sept. Estonia kontserdisaalis, 11. sept. Endla teatri küünis Pärnus, 12. sept. Kultuurivaras Kuressaares

Response of rat prostate and lung tumors to ionizing radiation combined with the angiogenesis inhibitor AMCA

Energy Technology Data Exchange (ETDEWEB)

Kal, H.B. [Dept. of Radiotherapy, Univ. Medical Centre Utrecht (Netherlands); Struikmans, H. [Dept. of Radiotherapy, Univ. Medical Centre Utrecht (Netherlands); Dept. of Radiotherapy, Medical Centre Haaglanden, Westeinde Hospital, The Hague (Netherlands); Gebbink, M.F.B.G.; Voest, E.E. [Dept. of Medical Oncology, Univ. Medical Centre Utrecht (Netherlands)

2004-12-01

Aim: to determine whether radiation combined with Trans-4-AminoMethyl cyclohexane carboxylic acid (AMCA, or tranexamic acid, Cyklokapron registered) results in a better tumor response than radiation alone. Materials and methods: we evaluated the responses of the L44 lung tumor in BN rats and R3327-MATLyLu (MLL) prostate tumor in Copenhagen rats, to single and fractionated X-ray doses with and without AMCA (1.5 g/kg). Tumors were grown subcutaneously in the flank of the animal. AMCA was administered subcutaneously twice daily for at least 2 weeks. Response to treatment was evaluated according to excess growth delay and specific growth delay. Results: L44 and MLL tumors treated with AMCA only experienced a non-significant growth delay. L44 tumors treated with 4 daily dose fractions of 2.5 Gy had a significant excess and specific growth delay when treated with AMCA, the enhancement ratio was 1.6-1.7. The enhancement ratio based on the calculated excess biologically effective dose of the linear-quadratic concept was 1.4-1.5. MLL tumors treated with a single dose of 20 Gy and AMCA had no significant excess growth delay. Conclusion: the enhancement ratio of 1.4-1.7 for the L44 tumor, but not for the MLL tumor, due to AMCA treatment, indicates that AMCA may potentiate the anti-tumor effect of ionizing radiation in distinct tumor types. (orig.)

Response of rat prostate and lung tumors to ionizing radiation combined with the angiogenesis inhibitor AMCA

International Nuclear Information System (INIS)

Kal, H.B.; Struikmans, H.; Gebbink, M.F.B.G.; Voest, E.E.

2004-01-01

Aim: to determine whether radiation combined with Trans-4-AminoMethyl cyclohexane carboxylic acid (AMCA, or tranexamic acid, Cyklokapron registered) results in a better tumor response than radiation alone. Materials and methods: we evaluated the responses of the L44 lung tumor in BN rats and R3327-MATLyLu (MLL) prostate tumor in Copenhagen rats, to single and fractionated X-ray doses with and without AMCA (1.5 g/kg). Tumors were grown subcutaneously in the flank of the animal. AMCA was administered subcutaneously twice daily for at least 2 weeks. Response to treatment was evaluated according to excess growth delay and specific growth delay. Results: L44 and MLL tumors treated with AMCA only experienced a non-significant growth delay. L44 tumors treated with 4 daily dose fractions of 2.5 Gy had a significant excess and specific growth delay when treated with AMCA, the enhancement ratio was 1.6-1.7. The enhancement ratio based on the calculated excess biologically effective dose of the linear-quadratic concept was 1.4-1.5. MLL tumors treated with a single dose of 20 Gy and AMCA had no significant excess growth delay. Conclusion: the enhancement ratio of 1.4-1.7 for the L44 tumor, but not for the MLL tumor, due to AMCA treatment, indicates that AMCA may potentiate the anti-tumor effect of ionizing radiation in distinct tumor types. (orig.)

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells.

Science.gov (United States)

Zhang, L; Xie, Y H; Lin, B R

2015-08-14

We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used to observe the formation of mineralized nodules after cell mineralization and induction for 10 and 20 days under different culture conditions, and the areas of the mineralized nodules formed 20 days after induction were computed. The addition of 1, 10, and 100 mL/L WPLTs or PRP significantly promoted rat dental pulp cell proliferation (P 0.05). Under the same concentrations, no significant differences on cell proliferation were observed between WPLT and PRP treatments (P > 0.05 in all groups). After 10 days mineralization and culture, the 100 and 500 mL/L WPLT and PRP group positive nodule rates were significantly higher than those of the low concentration and the control groups (P < 0.05). After 20 days, the areas of the mineralized nodules formed in the 100 and 500 mL/L WPLT and PRP groups were significantly larger than those in the control group (P < 0.05). These results demonstrate that both WPLTs and PRP are equally able to significantly promote the proliferation and calcification of rat dental pulp cells under a certain range of concentrations.

Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish.

Science.gov (United States)

Savoldi, Robson; Polari, Daniel; Pinheiro-da-Silva, Jaquelinne; Silva, Priscila F; Lobao-Soares, Bruno; Yonamine, Mauricio; Freire, Fulvio A M; Luchiari, Ana C

2017-01-01

The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich in N , N -dimethyltryptamine (DMT) and monoamine oxidase inhibitors, with properties similar to those of serotonin. Despite substantial progress in the development of new drugs to treat anxiety and depression, current treatments have several limitations. Alternative drugs, such as ayahuasca, may shed light on these disorders. Here, we present time-course behavioral changes induced by ayahuasca in zebrafish, as first step toward establishing an ideal concentration for pre-clinical evaluations. We exposed adult zebrafish to five concentrations of the ayahuasca infusion: 0 (control), 0.1, 0.5, 1, and 3 ml/L ( n = 14 each group), and behavior was recorded for 60 min. We evaluated swimming speed, distance traveled, freezing and bottom dwelling every min for 60 min. Swimming speed and distance traveled decreased with an increase in ayahuasca concentration while freezing increased with 1 and 3 ml/L. Bottom dwelling increased with 1 and 3 ml/L, but declined with 0.1 ml/L. Our data suggest that small amounts of ayahuasca do not affect locomotion and reduce anxiety-like behavior in zebrafish, while increased doses of the drug lead to crescent anxiogenic effects. We conclude that the temporal analysis of zebrafish behavior is a sensitive method for the study of ayahuasca-induced functional changes in the vertebrate brain.

Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish

Directory of Open Access Journals (Sweden)

Robson Savoldi

2017-07-01

Full Text Available The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich in N, N-dimethyltryptamine (DMT and monoamine oxidase inhibitors, with properties similar to those of serotonin. Despite substantial progress in the development of new drugs to treat anxiety and depression, current treatments have several limitations. Alternative drugs, such as ayahuasca, may shed light on these disorders. Here, we present time-course behavioral changes induced by ayahuasca in zebrafish, as first step toward establishing an ideal concentration for pre-clinical evaluations. We exposed adult zebrafish to five concentrations of the ayahuasca infusion: 0 (control, 0.1, 0.5, 1, and 3 ml/L (n = 14 each group, and behavior was recorded for 60 min. We evaluated swimming speed, distance traveled, freezing and bottom dwelling every min for 60 min. Swimming speed and distance traveled decreased with an increase in ayahuasca concentration while freezing increased with 1 and 3 ml/L. Bottom dwelling increased with 1 and 3 ml/L, but declined with 0.1 ml/L. Our data suggest that small amounts of ayahuasca do not affect locomotion and reduce anxiety-like behavior in zebrafish, while increased doses of the drug lead to crescent anxiogenic effects. We conclude that the temporal analysis of zebrafish behavior is a sensitive method for the study of ayahuasca-induced functional changes in the vertebrate brain.

PÖFFil võidutses Aasia / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2005-01-01

Auhinnad IX PÖFFi Euraasia võistlusprogrammi filmidele. Grand prix läks hiina filmile "Shanghai unistus" (režii Wang Xiaoshuai). Žürii liikmed Eva Isaksen, Thomas Mauch, Jaak Allik, Sven Grünberg avaldavad lühiarvamusi. Lisatud nimekiri "9. Pimedate Ööde filmifestival andis välja järgmised auhinnad"

Vratshi i medsestrõ... za bortom peregovorov / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2007-01-01

Eesti Arstide Liit ja Eesti Keskastme Tervishoiutöötajate Kutseliit ei kiida heaks lepingut, mis kehtib vaid Haiglate Liidu liikmetele ja jätab palgatõusust ilma terve rea tervishoiutöötajaid. Tervishoiutöötajad pöörduvad kohtusse. Vt. samas: Kokkuvõtteks; Kommenteerivad: Eesti Arstide Liit, sotsiaalminister Jaak Aab, riiklik lepitaja Henn Pärn

Vaba mõtte filmid / Raimo Jõerand

Index Scriptorium Estoniae

Jõerand, Raimo, 1970-

2009-01-01

Lähima poole aasta jooksul esilinastuvatest Eesti dokumentaalfilmidest : Peeter Brambati "Kosmos'68", Jaan Tootseni-Jaak Kilmi "Uus maailm", Juri Hatšavatski-Marianna Kaati "Ajuoperatsioon", Ilmar Raagi-Kiur Aarma "September", Marianne Kõrveri "7 motiivi", Kristiina Davidjantsi "Palusalu", Liina Triškina-Indrek Treufeldti "1939", Mihkel Kärmase-Rasmus Kagge "Riigireetur", Artur Talviku "Baruto - tõlkes kaduma läinud"

Kalevi kommivabrik läks Luksemburgi investeerimisfondile / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2007-01-01

Kalevi ja Tere omandanud Luksemburgis registreeritud fondi Alta Capital Partners S.C.A. osanikud on 80% ulatuses Indrek Rahumaa, Andres Rätsepp, Jaak Raid ja Marius Binkevicius, 20% osakutest kuulub Briti varahaldusfirmale Bonfield Asset Management. Fondi hakkab haldama Läti firma Alta Capital Partners SIA. Skeemid: Mis Oliver Kruudale alles jäi? Mida Indrek Rahumaa ostis

Dzhässimaal, avalik loomevabadus / Tui Hirv

Index Scriptorium Estoniae

Hirv, Tui, 1984-

2008-01-01

20. aprillil Tallinna Kunstihoones toimunud üritusest Dzhässimaal, kus improviseeris 20.04.2008 Estonian Guitar Octet koosseisus Jaak Sooäär, Paul Daniel, Robert Jürjendal, Tõnis Leemets, Virgo Sillamaa, Mart Soo, Kalle Tikas ja Tarvo Kaspar Toome. Samal ajal maalisid pilte noored kunstnikud Tallinna kunstikoolist, Sally stuudiost ja Pelgulinna kunstigümnaasiumist

Modernismi tõlgendamine jätkub / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2007-01-01

Rahvusvaheline kunstiajalookonverents "Erinevad modernismid, erinevad avangardid. Kesk- ja Ida-Euroopa kunstiprobleemid pärast Teist maailmasõda" Kumu Kunstimuuseumis 27. ja 28. IX. Esinejad: Irena Buzhinska, David Crowley, Branislav Dmitrijevic, Sirje Helme, Henry Meyric Hughes, Jaak Kangilaski, Liljana Kolesnik, Andres Kurg, Vojtech Lahoda, Steven Mansbach, Pjotr Piotrowski, Stefanie Reetz, Susan E. Reid, Skaidra Trilupaite, Borut Vogelnik

Inimesed, kes on armunud filmi / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2001-01-01

UNICA festivali korraldaja Jaak Järvise abiga antud ülevaade Tallinnas 3.-12. augustini toimuvast UNICA 63. ülemaailmsest amatöörfilmide festivalist. Ka nimekiri selle raames toimunud üheminutiliste filmide maailmameistrivõistluste tulemustest, kus ühe kolmanda preemia sai Tõnu Aru ja Eve Esteri "Friendly". Põhiprogrammis võistleb ka Tõnu Aru "Elu on niisugune"

Näidendivõistluse võitis lugu buumijärgsest ängist / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2011-01-01

Eesti teatriagentuuri näidendivõistluse võitis Piret Jaaks näidendiga "Näha roosat elevanti", teise koha said Jan Rahmani "Lell" ja Donald Tombergi "Andmed Liina Pihlapuust" ning kolmanda koha Paavo Piik "Keti lõpp" ja Kadri Noormets "GO NEO UND ROMANTIX". Lühinäidendi eripreemia läks Küllike Veedele "Puudutamata" eest

Sirbi tegijad läbi aegade

Index Scriptorium Estoniae

2004-01-01

Toimetaja asetäitjad: Katrin Kivimaa, Reet Varblane jt. Kunst, arhitektuur: Alo Hoidre, Boris Lukats, Ressi Kaera, Jaak Olep, Ike Volkov, Mirjam Peil, Tiina Käesel, Katrin Kivimaa, Vappu Vabar, Reet Varblane, Mari Laaniste. Kunstnikud (arvutikujundus): Tõnu Soo, Ann Gornischeff, Gädvi Kuklase, Piia Ruber. Fotograafid: Solomon Rosenfeldt, Endel Köster, Kalju Suur, Arno Saar, Teet Malsroos

Radar tegi Moora küla kuulsaks / Aarne Mäe

Index Scriptorium Estoniae

Mäe, Aarne

2003-01-01

Kellavere mäel avati Eesti võimsaim õhuseireradar, USA päritolu Lockhead-Martini radar TPS-117. Laekvere vallavanem Aarne Laasi ja õhuseiredivisjoni ülem jaak Tarien'i kommentaarid. Foto: President Arnold Rüütel ja kaitseväe juhataja viitseadmiral Tarmo Kõuts tulevad koos teiste külalistega radari sisseõnnistamiselt, mis sai endale hellitusnimeks Piret

Betoonkamakas rannamändide vahel / Urmas Oja

Index Scriptorium Estoniae

Oja, Urmas, 1981-2012

2006-01-01

Omapäraselt karm, ent loodusega kontakti otsiv luksuslik betoonist rannavilla Tallinna lähedal asuvas eramurajoonis. Villale lisavad läbipaistvust nurgapostideta nurgaaknad. Projekteerija: OÜ Eensalu & Pihel. Arhitektid Laur Pihel ja Tauno Aadma. Sisearhitekt Jaak Jõevee. Projekt 2004, valmis 2006. Ill.: I ja II korruse plaan, 4 värv. välis- ja 8 sisevaadet

Isiklik puudutus Pärnust / Siram

Index Scriptorium Estoniae

Siram, pseud., 1968-

2004-01-01

Andrus Joonase kureeritud näitus "Kunst on halb, kunst on hea" Pärnu Uue Kunsti Muuseumis 20. X-20. XI. Mila Balti, Toomas Kuusingu, Asta Isaki, Pille Neeve, Remo Randveri, Ville-Karel Viirelaiu, Non Grata, Mark Soosaare, Svea Aaviku, Meeland Sepa, Andrus Joonase, Urmas Martinsoni, Kadri Alesmaa, Jaak Visnapi ja Viljar Kõivu töödest

Elamusi ujuvast linnast / Krister Kivi

Index Scriptorium Estoniae

Kivi, Krister, 1975-

2007-01-01

Reportaaž Eesti presidendi Toomas Hendrik Ilvese külaskäigust maailma pikimale ja maailma esimesele tuumajõul töötavale lennukikandjale USS Enterprise. Delegatsiooni kuulusid veel Riigikogu esimees Ene Ergma, kaitseväe juht Ants Laaneots, kaitseminister Jaak Aaviksoo, Riigikogu liikmed Sven Mikser ja Mati Raidma ning USA suursaadik Eestis Stanley Davis Phillips

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11 leukemia cells.

Directory of Open Access Journals (Sweden)

Carolin Bier

Full Text Available BACKGROUND: The chromosomal translocation t(4;11(q21;q23 is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic transcriptional activation. Hence, Taspase1's proteolytic activity is a critical step in AF4•MLL pathophysiology. The Taspase1 proenzyme is autoproteolytically processed in its subunits and is assumed to assemble into an αββα-heterodimer, the active protease. Therefore, we investigated here whether overexpression of catalytically inactive Taspase1 variants are able to interfere with the proteolytic activity of the wild type enzyme in AF4•MLL model systems. METHODOLOGY/FINDINGS: The consequences of overexpressing the catalytically dead Taspase1 mutant, Taspase1(T234V, or the highly attenuated variant, Taspase1(D233A, on Taspase1's processing of AF4•MLL and of other Taspase1 targets was analyzed in living cancer cells employing an optimized cell-based assay. Notably, even a nine-fold overexpression of the respective Taspase1 mutants neither inhibited Taspase1's cis- nor trans-cleavage activity in vivo. Likewise, enforced expression of the α- or β-subunits showed no trans-dominant effect against the ectopically or endogenously expressed enzyme. Notably, co-expression of the individual α- and β-subunits did not result in their assembly into an enzymatically active protease complex. Probing Taspase1 multimerization in living cells by a translocation-based protein interaction assay as well as by biochemical methods indicated that the inactive Taspase1 failed to assemble into stable heterocomplexes with the wild type enzyme. CONCLUSIONS: Collectively, our results demonstrate that inefficient heterodimerization appears to be the mechanism by which inactive Taspase1 variants fail to inhibit wild type Taspase1's activity in trans. Our work favours strategies targeting Taspase1's catalytic activity

Improvement of Haramay Fiber by Pre-treatment of Retting Process withPhosphoric Acid

International Nuclear Information System (INIS)

Kuntari-Sasas; Neni-Rustini Eriawati

2000-01-01

Haramay as bast fiber contains of cellulose fiber as the main part, mixedwith hemi cellulose, pectin, and lignin as binding material for cellulosefiber to keep it together in the bundle form. For textile material, this bastfiber has to be freed from its binding material, called as retting process,before subjecting to scouring, dyeing and finishing process in textileindustry. In the retting process the dissolve of binding material can be doneeither by using enzyme in bio technology or extraction with strong alkalinecondition in common technology. Using sodium hydroxide for dissolving thebinding material can be carried out easily with good dissolving ability, butcan render the strength retention of the cellulose fiber. Pre-treatment ofthe bast fiber with phosphoric acid (H 3 PO 4 ), is expected to hydrolyze someof the binding materials that can not be dissolved in alkaline condition,including natural pigment that colored the fiber with creamy white. In thisstudy, the pre-treatment process before retting with phosphoric acid wascarried out in various condition, such as concentration of phosphoric acid (5ml/l- 25 ml/l), time and temperature of pre-treatment (1-3 hours at 50 o C or12-24 hours at room temperature), followed by neutralization in dilutealkaline. The retting process was carried out by means of scouring in variousconcentration of sodium hydroxide (NaOH 38 o Be, 10 ml/l-30 m/l), and then wascontinued with bleaching process in hydrogen peroxide solution. Aftercarrying out those experiment, the bast fiber that called haramay wassubjected to testing for weight reduction, strength retention and degree ofwhiteness. From the testing results it is concluded that pre-treatment withphosphoric acid can increase the weight reduction, strength retention ortenacity and degree of whiteness of haramay fiber compared to the oneswithout pre-treatment with phosphoric acid. The best result was obtained bypre-treatment with 5 ml/l H 3 PO 4 at 50 o C for 2 hours, continued by

UNICA festivalilt Hollandis / Jaak Järvine

Index Scriptorium Estoniae

Järvine, Jaak

2000-01-01

Filmiamatööride 62. rahvusvahelisest festivalist Roemondis Hollandis "UNICA 2000", kus žürii avalikule istungile pääses ka tallinlase Karmo Kaasiku "Loot(d)us sureb viimasena" ja UNICA filmiarhiivi valiti Tallinna Kanutiaia Noortemaja stuudio mängufilm "Aleksandra". 63. festival toimub järgmisel aastal Tallinnas

Unenägude isaisad / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2000-01-01

13.-30.augustini linastub Tallinna Linnaarhiivi hoovis, Pärnu Chaplini kunstikeskuse terrassil ja Haapsalu piispopilinnuse siseõuel 1920. aastate 6 saksa tummfilmi üldpealkirjaga "Türannide galerii". Lühidalt filmidest

Kuldne Palmioks Rumeenia realismile / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

60-nda Cannes'i filmifestivalist, auhinnasaajatest, eelkõige Kuldse Palmioksa saanud Christian Mungiu filmist "Neli kuud, kolm nädalat ja kaks päeva" (Rumeenia), Kadri Kõusaare "Magnuse" osalemisest. Lisatud auhinnasaajate nimekiri

Pickwick teatrilaboris / Berk Vaher, Jaak Tomberg

Index Scriptorium Estoniae

Vaher, Berk, 1975-

2000-01-01

Brian D. Barnesi ühemeheteatri etendusest "The Pickwickians at Manor Farm" (Charles Dickensi romaani "Pickwick klubi paberid" ainetel) Tallinna Linnateatris 18. okt. ja Tartu Teatrilabori majas 20. okt

Kunstiteose-essee kunstiteaduslikust aktuaalsusest / Jaak Tomberg

Index Scriptorium Estoniae

Tomberg, Jaak, 1980-

2010-01-01

Walter Benjamini esseest "Kunstiteos oma mehhaanilise reprodutseeritavuse ajastul" (1936), mis näitab kuidas uued reproduktiivsed tehnikad raputavad kunstivalla kõige sisimat tuuma, tühistades kunsti kogu senise "eelloo". Selle aktuaalsusest ka nüüdisajal ja mõjust rahvusvahelistes teoreetilistes aruteludes kunstiteose nüüdisaegse olemuse üle, tema staatuse üle uue meedia keskkonnas

Laste ja kunsti nimel / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2003-01-01

Beliini 53. filmifestivali Kuldkaru sai briti režissööri Michael Winterbottomi "Siin maailmas" ("In this World"), Hõbekaru läks ameerika filmile "Adaptatsioon" ("Adaptation" : režissöör Spike Jonze), parima lavastaja Hõbekaru sai prantslane Patrice Chereau filmi "Tema vend" ("Son frere") eest. Lisatud tähtsamate auhindade saajate nimekiri

Kas surm koos pensioniga? / Jaak Aab

Index Scriptorium Estoniae

Aab, Jaak, 1960-

2007-01-01

Ilmunud ka: Harju Ekspress, 14. sept. 2007, lk. 4; Lääne Elu, 22. sept. 2007, lk. 2; Põhjarannik, 15. sept. 2007, lk. 2; Severnoje Poberezhje, 15. sept. 2007, lk. 2; Võrumaa Teataja, 15. sept. 2007, lk. 2; Vooremaa, 15. sept. 2007, lk. 2; Meie Maa, 14. sept. 2007, lk. 2; Valgamaalane, 18. sept. 2007, lk. 2; Virumaa Teataja, 20. sept. 2007, lk. 15; Koit, 20. sept. 2007, lk. 6. Parlamendiliige, keskerakondlane kritiseerib Reformierakonna ettepanekut tõsta pensioniiga

Arhitekti rolli muutused Rootsis / Jaak Poom

Index Scriptorium Estoniae

Poom, Jaak

1996-01-01

Arhitekt ئ tellija usaldusmees (1945-1950). Elamuehitus saab peamiseks ülesandeks (1950-1960). Miljoniprogramm (1960-1970). Arhitekt ühiskonna põlu all (1970-1980). Postmodernismja turumajandus (1980-1990). Tänapäev ja tulevik (1990-?).

Kunstiorganisatsioonide tasalülitamine / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2013-01-01

Eesti Nõukogude Kunstnike Liidu loomise järel saadeti laiali senised kunstnike vabatahtlikud organisatsioonid ja rühmitused. Institutsionaalsed ümberkorraldused aitasid kunstnikkonda tasalülitada

Saksa okupatsioon [1941-44] / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2013-01-01

Natsionaalsotsialistlik kunstiideoloogia ja -poliitika. Natsionaalsotsialistliku kunsti propaganda. Kunstielu korraldus. Kunstiharidus. Kunstimuuseumid. Näitused ja kunsti rahastamine. Kunstikriitika. Maalikunst

Teel tagasi laste juurde / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2005-01-01

Cannes'i 58. filmifestivalilt : Jean-Pierre ja Luc Dardenne'i "Laps" ("L'Enfant"), Jim Jarmuschi "Murtud lilled" ("Broken Flowers"), Wim Wendersi "Ära tule koputama" ("Don't Come Knocking"), Michael Haneke "Varjatud" ("Cache")

Tuntud tundmatud Ungari filmid / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Sõpruse kinos kestab 25. oktoobrini filmiprogramm "Vabaduse tuuled" Ungari 1956.a. ülestõusule pühendatud mängufilmide programm (6 ungari filmi aastaist 1965-2004) : Ungari Instituudi, kino "Sõprus" ja PÖFFi koostööprojekt. Lähemalt Peter Bacso komöödiafilmist "Tunnistaja" (1969) ja Miklos Jancso filmist "Lootuseta" (1965)

Cannes'i üllatused / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Cannes'i filmifestivali võitjad. Kuldne Palmioks läks Ken Loachi mängufilmile "Kesva heljutab tuul" ("The Wind That Shakes the Barley"), Grand Prix' sai Bruno Dumonti "Flandria sõdalased" ("Flandres"), parim režissöör - Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja - näitlejannad Pedro Almodovari filmist "Naasta" ("Volver"), parim meesnäitleja - grupp näitlejaid filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi psühholoogilisele draamale "Punane tänav" ("Red Road")

Palmovaja vetv - krititsheskomu realizmu / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Cannes'i filmifestivali võitjad. Kuldse Palmioksa võitis Ken Loachi mängufilm "Tuul, mis sasib odrapõldu" ("The Wind That Shakes the Barley"), Grand Prix' sai prantslase Bruno Dumonti film "Flandria" ("Flandres"), parim režissöör oli Alejandro Gonzalez Inarritu filmi eest "Paabel" ("Babel"), parima naisnäitleja auhinna sai grupp näitlejannasid Pedro Almodovari filmist "Tagasipöördumine" ("Volver") ja meesnäitleja auhinna sai samuti grupp näitlejaid prantsuse filmist "Kuulsuse päevad" ("Indigenes"). Žürii eriauhind läks Andrea Arnoldi filmile "Punane tänav" ("Red Road")

Hooaeg New Yorgis / Jaak Rähesoo

Index Scriptorium Estoniae

Rähesoo, Jaak, 1941-

1999-01-01

Joseph Chaikini, Samuel Becketti ja Sam Shepardi näidendite lavastused. Ameerika teatriuuendajate Richard Foremani ja Lee Breueri lavastustest. Järg vt. nr. 3, lk. 33-40, 96; nr. 4, lk. 33-42; nr. 5, lk. 37-45

Menu hind on valu? / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2004-01-01

Mõtisklusi "Mosfilmis" 1984 valminud mängufilmi "Menu" ainetel, mis kujutab teatri köögipoolt. Sellega seoses arutleb autor lavastaja- ja näitejatöö üle, kunstinõukogude koosolekute osast lavastuse vastuvõtul, teatritöö eetikast

Vene teatri eliit Eestisse / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

2009-01-01

Venemaa teatrifestivalist "Kuldne mask", pikemalt sügisel 6.-13. okt. Eestis mängitavatest lavastustest - Alvis Hermanise "Šukšini lood" Jevgeni Mironoviga peaosas, Aleksandr Ostrovski "Äike" Lev Erenburgi lavastuses, "Onukese unenägu" Oleg Basilašviliga peaosas ja William Shakespeare'i "Kaheteistkümnes öö" Declan Donnellani lavastuses

Propaganda rahva raha eest / Jaak Juske

Index Scriptorium Estoniae

Juske, Jaak, 1976-

2006-01-01

Keskerakond on enda ülistamisel maksumaksja raha eest kaotanud igasuguse mõõdutunde, kirjutab autor. Tema sõnul pole Tallinnas ilmuvad 9 ajalehte mõeldud võimuerakonna propagandaks ning Tallinna linna palgal on üle 20 pressi- ja avaliku suhete nõuniku, neist suurem osa on Keskerakonnaga seotud

Loetud tunnid viienda Potterini / Jaak Urmet

Index Scriptorium Estoniae

Urmet, Jaak, 1979-

2003-01-01

J. K. Rowlingi "Harry Potter and the Order of the Phoenix" ("Harry Potter ja Fööniksi ordu") paisatakse müüki 21. juunil; samast päevast saab ka eestikeelset väljaannet tellida, mis ilmub oktoobris, ka reklaaamikampaaniast USAs

Rain Simmul sai mehise näitleja auhinna / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2002-01-01

Bakuu rahvusvaheline filmilmifestival "Ida-Lääs", kus Rain Simmul sai oma rolli eest Arvo Iho filmis "Karu süda" diplomi. Näidati ka Peeter Simmi mängufilmi "Head käed" ja Andres Maimiku - Jaak Kilmi tõsielufilmi "Isamaa ilu". "Karu süda" on saanud ka Jack Londoni nimelise parima stsenaariumiga filmi auhinna California filmifestivalil Wine Country

Tjoplõi dozhd v zale suda / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2006-01-01

Mängufilm "Meeletu" : stsenaristid Jaan Tätte, Elmo Nüganen : režissöör Elmo Nüganen : operaator Mait Mäekivi : produtsent Kristian Taska : helilooja Jaak Jürisson : peaosas Rain Simmul : Taska Film - Eesti Televisioon 2006. Võrreldakse näidendi lavastust ja filmi. Arvustuses on Jüri osatäitjaks ekslikult nimetatud lavastuse osatäitjat Allan Noormetsa ( tegelikult Aivar Tommingas)

Näitused kunstiakadeemias

Index Scriptorium Estoniae

2003-01-01

EKA galeriis näitusel "Kirju pall" esitavad "krutskilist ökokunsti" rühmitus Puhas Rõõm, Mart Viljus, Anu Vahtra, Maris Mändel, Katrin Tees, Reimo Võsa-Tangsoo, Erki Kasemets, Raivo Hool. Aula fuajees näeb Jaak Soansi juhendamisel valminud skulptuuriosakonna õppetöid, valdavalt poliitikute skulptuurportreid. Osalevad Kristiina Järvelaid, Jelena Levtshenkova, Rene Reinumäe, Kaisa Uusoksa, Marju Vaher

Moskvast tuli Eestisse Hõbe-Jüri / Kristiina Davidjants

Index Scriptorium Estoniae

Davidjants, Kristiina, 1974-

2004-01-01

Moskvas lõppes XXVI rahvusvaheline filmifestival. Festivali programmi kuulus ka Renee Reinumäe, Jaak Kilmi noortefilm, mis sai žürii eripreemia, Hõbedase Püha Jüri. Peapreemia sai venelase Dmitri Meshijevi "Omad". Noorte lootustandvate režissööride programmis oli huvitav prantslase Christophe Honoré "Minu ema". Lisatud auhinnatute nimekiri ning nimekiri "Eesti filmide tähtsamaid autasusid"

Omad võõraste hulgas / Viktor Matizen ; tõlk. Tamara Korts

Index Scriptorium Estoniae

Matizen, Viktor

2004-01-01

Moskvas lõppes XXVI rahvusvaheline filmifestival. Peapreemia sai venelase Dmitri Meshijevi "Omad" ("Svoi"), FIPRESCI auhinna Marina Razbezhkina "Lõikuse aeg" ("Vremja zhatvõ"), publiku auhinna Vladimir Mashkovi "Isa" ("Papa!"), vene kriitikute auhinna brasiillase Heitor Dhalia "Nina", konkursi "Perspektiiv" auhinna jaapanlane Hideta Takahata ("Hotell Veenus") ja žürii eriauhinna Hõbedase Püha Jüri eestlaste Jaak Kilmi ja Rene Reinumägi "Sigade revolutsioon"

Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements.

Science.gov (United States)

Biechonski, Shahar; Gourevich, Dana; Rall, Melanie; Aqaqe, Nasma; Yassin, Muhammad; Zipin-Roitman, Adi; Trakhtenbrot, Luba; Olender, Leonid; Raz, Yael; Jaffa, Ariel J; Grisaru, Dan; Wiesmuller, Lisa; Elad, David; Milyavsky, Michael

2017-02-15

Quercetin (Que) is an abundant flavonoid in the human diet and high-concentration food supplement with reported pro- and anti-carcinogenic activities. Topoisomerase II (TopoII) inhibition and subsequent DNA damage induction by Que was implicated in the mixed lineage leukemia gene (MLL) rearrangements that can induce infant and adult leukemias. This notion raised concerns regarding possible genotoxicities of Que in hematopoietic stem and progenitor cells (HSPCs). However, molecular targets mediating Que effects on DNA repair relevant to MLL translocations have not been defined. In this study we describe novel and potentially genotoxic Que activities in suppressing non-homologous end joining and homologous recombination pathways downstream of MLL cleavage. Using pharmacological dissection of DNA-PK, ATM and PI3K signalling we defined PI3K inhibition by Que with a concomitant decrease in the abundance of key DNA repair genes to be responsible for DNA repair inhibition. Evidence for the downstream TopoII-independent mutagenic potential of Que was obtained by documenting further increased frequencies of MLL rearrangements in human HSPCs concomitantly treated with Etoposide and Que versus single treatments. Importantly, by engaging a tissue engineered placental barrier, we have established the extent of Que transplacental transfer and hence provided the evidence for Que reaching fetal HSPCs. Thus, Que exhibits genotoxic effects in human HSPCs via different mechanisms when applied continuously and at high concentrations. In light of the demonstrated Que transfer to the fetal compartment our findings are key to understanding the mechanisms underlying infant leukemia and provide molecular markers for the development of safety values. © 2016 UICC.

Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.

Science.gov (United States)

Gu, De-Leung; Chen, Yen-Hsieh; Shih, Jou-Ho; Lin, Chi-Hung; Jou, Yuh-Shan; Chen, Chian-Feng

2013-12-21

High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, ARID2, MLL, MLL2, MLL3, MLL4, IRF2, ATM, CDKN2A, FGF19, PIK3CA, RPS6KA3, JAK1, KEAP1, NFE2L2, C16orf62, LEPR, RAC2, and IL6ST. Functional classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling, Wnt/β-catenin signaling, JAK/STAT signaling, and oxidative stress play critical roles in HCC tumorigenesis. Nevertheless, because there are few druggable genes used in HCC therapy, the identification of new therapeutic targets through integrated genomic approaches remains an important task. Because a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain, copy number alteration (CNA) analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons, homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC progression. Moreover, integration of CNAs with other high-throughput genomic data, such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models, provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients.

Archaeological investigations on the site of the cistercian nunnery of st. Michael / Mauri Kiudsoo, Irita Kallis

Index Scriptorium Estoniae

Kiudsoo, Mauri

2005-01-01

2004. aasta suvel Tallinnas Suur-Kloostri 2 kinnistul toimunud kaevamistest. Leidis kinnitust hüpotees, mille kohaselt hävitati kloostri rajamisel mingi varasem asustusvorm. Arheoloogilise stratigraafia analüüsil ja fikseerimisel kasutati Edward C. Harrise koostatud stratigraafia teooria ja metoodika põhimõtteid ja nn. Harrise maatriksit

Kolm küsimust esimese leedi kandidaatidele

Index Scriptorium Estoniae

2001-01-01

Tiia Tulviste, Kirsti Savi, Sirje Priimägi, Mari-Ann Kelam ja Mari Tarand vastavad küsimustele, kuidas nad suhtuvad sattumisse presidendikampaaniasse, millisena nad näevad enda rolli presidendivalimiste kampaanias ja mida nad tahaksid teha esimese leedina. Eesti presidendi abikaasa rollist ühiskonnast räägivad Jaak Allik, Enn Eesmaa, Toomas Tiivel, Vilja Savisaar ja Gunnar Paal. Parlamendisaadik (M.-A. Kelam)

Sotsiaalselt pime ja poliitiliselt impotentne teater / Alvar Loog

Index Scriptorium Estoniae

Loog, Alvar

2006-01-01

Poliitilisest ja sotsiaalsest teatrist Eestis 2005. aasta lavastuste põhjal : Pip Upponi "Adolf" Tartu Püssirohukeldris, lavastaja Ervin Õunapuu; Merle Karusoo "Misjonärid" Rakvere Teatris; Alistair Beatoni "Õnnetunne" Ugalas, lavastaja Jaak Allik; Toomas Kalli " Viimane sent" Vana Baskini Teatris, lavastaja Eino Baskin; George Orwelli "Loomade farm" Tallinna Linnateatris, lavastaja Mart Koldits; Kai Henseli "Klammi sõda" VAT Teatris, lavastaja Aare Toikka

Mida tegi peaminister Ansip 20 aastat tagasi? / Tarmo Vahter

Index Scriptorium Estoniae

Vahter, Tarmo, 1970-

2007-01-01

Endine Tartu KEK-i juhataja Jaak Kalm ja Tartu linna täitevkomitee aseesimees Robert Närska 1988. a. 2. veebruari meeleavaldusest ja selle laialiajamisest Tartus. Andrus Ansipi väidetavast kommentaarist meeleavalduse laialiajamisel. Peaminister Andrus Ansipi vastuseid küsimustele, miks EKP Tartu rajoonikomitee ei valinud teda 1988. a. rajoonikomitee II sekretäriks; kus ta viibis 2. veebruaril 1988. Lisa: Mida näitavad dokumendid

Mis see jumal meid on loonud? / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2017-01-01

Eesti teatriuuenduse 1969 aastal lavastas Evald Hermaküla Paul-Eerik Rummo näidendi "Tuhkatriinumäng", Jaan Tooming August Kitzbergi "Laseb käele suud anda". Jaak Alliku arvustus Jaan Toominga lavastusele ilmus ajakirjas Noorus 1970. aasta märtsinumbris pealkirjaga "Mis see jumal meid on loonud?". Sama küsimuse esitab artikli autor. Elumõttest, elu eesmärgist ja tähendusest

Kuressaare staadioni arhitektuurivõistlusest / Hannes Koppel

Index Scriptorium Estoniae

Koppel, Hannes

2011-01-01

2011. a. toimunud arhitektuurivõistlus staadionile parima arhitektuurse lahenduse leidmiseks oma senisel kohal Kuressaare lahe kaldal. Premeeritud töödest. 1. preemia pälvis võistlustöö "Maailmarekord", autorid Ott Kadarik ja Mihkel Tüür, 2. preemia võistlustöö "Victor", autorid Mari Renno ja Emil Urbel, 3. preemia võistlustöö "Saps", autorid Andres Lember, Jaak Huimerind ja Martin Ivask

Seitse raamatut ühtmoodi loodusest, kuid kõik erinevad / Ulvar Käärt, Mari Klein

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2009-01-01

Arvustus: Järva, Jaanus. Looduse aasta. Tallinn : Varrak, 2008; Järva, Jaanus. Raba : vaikuses ja varjus. Tallinn : Pegasus, 2008; Savisaar, Remo. Loodus kutsub. Tallinn : Varrak, 2008; Relve, Hendrik. Eesti looduse vägi. Tallinn : Koolibri, 2008; Tartes, Urmas, Põder, Jaak. Legendiloomad. Tallinn : Varrak, 2008; Eesti maastikud. Tallinn : Tänapäev, 2008; Veedla, Peep. Lindudega sõbraks / pildid joonistanud Triinu Ootsing. Tallinn : Berit Grupp, 2008

PENYELAMATAN EMBRIO Dendrobium anosmum Lindl. MELALUI KULTUR IN VITRO

Directory of Open Access Journals (Sweden)

Putu Yuni Astriani Dewi

2016-09-01

Full Text Available The aim of the research is to analyse germination percentage, effect of coconut water addition in the media to number of last stage embryos and development of final stage D. anosmum Lindl. embryo. Research was conducted at Plant Structure and Development of Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences University of Udayana and UPT. Balai Benih Induk Tanaman Pangan dan Hortikultura Provinsi Bali from February 2015 to July 2015. Three type of media were employed, i.e. PDA, Organic, MS. Three different concentration of coconut was added to media, i.e. 0 ml/L 50 ml/L, 100 ml/L. Results showed that seed D. anosmum Lindl. on PDA, Organic and MS has not germinated yet on all media, only swollen cells observed. Seed dormancy and maturity of seed were the main factors affecting seed germination.  Addition of 100 ml / L coconut water in MS showed that media is capable to increase the formation of final stages embryos (> 32 cells. Embryo development on PDA and Organic largely showed cell stage embryos 1 to 8 cells, while MS media already showed embryo development stages of > 32 cells.

Search for new high-mass particles decaying to Lepton pairs in pp collisions at square root s = 1.96 TeV.

Science.gov (United States)

Abulencia, A; Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben-Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Bourov, S; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Connolly, A; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cruz, A; Cuevas, J; Culbertson, R; Cyr, D; Daronco, S; D'Auria, S; D'onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; Dituro, P; Dörr, C; Dominguez, A; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallinaro, M; Galyardt, J; Garcia, J E; Garcia Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B-Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heijboer, A; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Huston, J; Ikado, K; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, Y K; Kirby, M; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korytov, A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreps, M; Kreymer, A; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecci, C; Lecompte, T; Lee, J; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P; McNamara, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Mulhearn, M; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Papikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K; Plager, C; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitin, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; van Remortel, N; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sanchez, C; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sill, A; Sinervo, P; Sisakyan, A; Sjolin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tönnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobouev, I; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Worm, S; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, Y; Yang, C; Yang, U K; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

2005-12-16

A search for new particles (X) that decay to electron or muon pairs has been performed using approximately 200 pb(-1) of pp collision data at (square root) s = 1.96 TeV collected by the CDF II experiment at the Fermilab Tevatron. Limits on sigma(pp --> X)BR (X --> ll) are presented as a function of dilepton invariant mass m(ll) > 150 GeV/c2, for different spin hypotheses (0, 1, or 2). The limits are approximately 25 fb for m(ll) > GeV/c2. Lower mass bounds for X from representative models beyond the standard model including heavy neutral gauge bosons are presented.

Mõtestatud käsitöölised / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

1999-01-01

Tartu Kunstikoolist väljakasvanud mööblikujundajate ئ Priit Verlin, Rain Pluutus, Priit Videvik, Maarja Inno, Dan Lukas ئ rühmitusest Class X Furniture. Nende loomingu vastandumisest trendiga, praegusest tegevusest jm. Toimetaja Ingo Maurer on valinud P. Verlini tooli 'Allegro' järgmisse Disaini Aastaraamatusse. Jaak Roosi oma põhimõtetest mööblikujundajate õpetamisel Tartu Kunstikoolis. Harry Liivranna arvamus. Kommentaarid: P. Verlin, R. Pluutus

Uued elamupiirkonnad / Lee Taal, Gea Velthut

Index Scriptorium Estoniae

Taal, Lee

1998-01-01

Lühiinfot: projektijuht, valmis elamud, infrastruktuur, arhitektuurne kontseptsioon, ehitajad, arhitektid jm. Maarjamäe elamupiirkond (AB Harmin, AB Urbel ja Peil, Alver Trummal Arhitektid), Vabaõhukooli tee asum (Künnapu & Padrik), Lepiku küla Kloostrimetsas /Lepiku Kinnisvarahooldus), Raudalu asum Viljandi mnt. ääres (R-Konsult, I. Raud), Kodu 2001 (Nordprojekt, Jaak Kruusmägi), Tiskre Haaberstis (Arhitektuuribüroo Alis), Randvere tee (Nordprojekt), Veskimöldre (Koot ja Koot).

NATO "röövib" Eestilt kogu jõueliidi / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2008-01-01

Bukarestis toimuvatel NATO tippkohtumisega seotud üritustel esindavad Eestit president Toomas Hendrik Ilves, peaminister Andrus Ansip, välisminister Urmas Paet, kaitseminister Jaak Aaviksoo ja kaitseväe juhataja kindralmajor Ants Laaneots. Poliitikute päevakavast. President T. H. Ilves esineb NATO temaatikaga tegelevate noorteorganisatsioonide esindajate konverentsil ning mõttekoja German Marshall Fund korraldataval konverentsil "The Bucharest Conference". Vabariigi President töövisiidil Bukarestis 1.-3.04.2008

Kevadfestival oli metsateemaline

Index Scriptorium Estoniae

2006-01-01

Üritustest 29. maist kuni 1. juunini Türi Kevadfestivali raames: Alo Põldmäe loodusfotode näituse "Muusikaline Neeruti" avamisest 30. mail Türi kultuurimajas, pianisti Kadri-Ann Sumera esinemisest festivali avakontserdil "Metsastseenid" 29. mail Türi kultuurimajas, regilaulude laulmisest Jaak Johansoni ja Riina Roose eestvedamisel ürituse "Ööülikool" raames 30. mail, koomilise laulumängu "Lopi ja Lapi" esietendusest 31. mail Oisu rahvamajas

TÜ bakalaureusetöid 2003

Index Scriptorium Estoniae

2004-01-01

Teatriteaduse erialal : Kerle Arula "Naised ja mehed Madis Kõivu näidendites. Feministliku kirjandusanalüüsi võimalusi "; Piret Jaaks "Populaarkultuuri ilminguid eesti teatris" ; Külli Paulus "Gooti romaan ja teater E. T. A. Hoffmanni "Kuradi eliksiiride" näitel" ; Käthe Pihlak "Lavastaja ja näitleja koostöö" ; Sirle Põdersoo "Näitlemine. Kaks vaateviisi" ; Merilin Raud "Mare Tommingase lavastus "Gypsy" ; Triinu Sillaste "Psühhodraama ja teater"

Aaviksoo goes to Washington

Index Scriptorium Estoniae

2010-01-01

Oma USA visiidi ajal kohtus kaitseminister Jaak Aaviksoo USA relvajõudude küberväejuhatuse ülema kindral Keith Alexander'iga ja sai ülevaate USA küberkaitsekorraldusest. Ministri ja USA Esindajatekoja järgmise koosseisu relvajõudude komitee esimehe Howard McKeon'i kohtumisel räägiti Euroopa ja Eesti praegusest julgeolekunägemusest. Kaitseministri plaanis oli ka kohtumine USA kaitseministri Robert Gates'iga

Biostimulant action of a plant-derived protein hydrolysate produced through enzymatic hydrolysis

Directory of Open Access Journals (Sweden)

Giuseppe eColla

2014-09-01

Full Text Available The aim of this study was to evaluate the biostimulant action (hormone like activity, nitrogen uptake, and growth stimulation of a plant-derived protein hydrolysate by means of two laboratory bioassays: a corn (Zea mays L. coleoptile elongation rate test (experiment 1, a rooting test on tomato cuttings (experiment 2; and two greenhouse experiments: a dwarf pea (Pisum sativum L. growth test (experiment 3, and a tomato (Solanum lycopersicum L. nitrogen uptake trial (experiment 4. Protein hydrolysate treatments of corn caused an increase in coleoptile elongation rate when compared to the control, in a dose-dependent fashion, with no significant differences between the four concentrations tested (0.375, 0.75, 1.5, and 3.0 ml/L, and inodole-3-acetic acid (IAA treatment. The auxin-like effect of the protein hydrolysate on corn has been also observed in the rooting experiment of tomato cuttings. The shoot, root dry weight, root length, and root area were significantly higher by 21%, 35%, 24%, and 26%, respectively in tomato treated plants with the protein hydrolysate at 6 ml/L than untreated plants. In experiment 3, the application of the protein hydrolysate at all doses (0.375, 0.75, 1.5, and 3.0 ml/L significantly increased the shoot length of the giberellin (GA-deficient dwarf pea plants by an average value of 33% in comparison with the control treatment. Increasing the concentration of the protein hydrolysate from 0 to 10 ml/L increased the total dry biomass, SPAD index, and leaf nitrogen content by 20.5%, 15% and 21.5%, respectively. Thus the application of plant-derived protein hydrolysate containing amino acids and small peptides elicited a hormone-like activity, enhanced nitrogen uptake and consequently crop performances.

The effect of cutting origin and organic plant growth regulator on the growth of Daun Ungu (Graptophyllum pictum) through stem cutting method

Science.gov (United States)

Pratama, S. P.; Yunus, A.; Purwanto, E.; Widyastuti, Y.

2018-03-01

Graptophyllum pictum is one of medical plants which has important chemical content to treat diseases. Leaf, bark and flower can be used to facilitate menstruation, treat hemorrhoid, constipation, ulcers, ulcers, swelling, and earache. G. pictum is difficult to propagated by seedling due to the long duration of seed formation, thusvegetative propagation is done by stem cutting. The aims of this study are to obtain optimum combination of cutting origin and organic plant growth regulator in various consentration for the growth of Daun Ungu through stem cutting method. This research was conducted at Research center for Medicinal Plant and Traditional DrugTanjungsari, Tegal Gede, Karanganyar in June to August 2016. Origin of cuttings and organic plant growth regulator were used as treatments factor. A completely randomized design (RAL) is used and data were analyzed by F test (ANOVA) with a confidence level of 95%. Any significant differences among treatment followed with Duncan test at a = 5%. The research indicates that longest root was resulted from the treatment of 0,5 ml/l of organic plant growth regulator. The treatment of 1 ml/l is able to increase the fresh and dry weight of root, treatment of 1,5 ml/l of organic plant growth regulator was able to increase the percentage of growing shoots. Treatment of base part as origin of cuttings increases the length, fresh weight and and dry weight of shoot, increase the number of leaves. Interaction treatment between 1 ml/l consentration of organic plant growth regulator and central part origin of cuttings is capable of increasing the leaf area, whereas treatment without organic plant growth regulator and base part as planting material affects the smallest leaf area.

IL-13 regulates human nasal epithelial cell differentiation via H3K4me3 modification

Directory of Open Access Journals (Sweden)

Yu L

2018-01-01

Full Text Available Lei Yu,1 Na Li,1 Jisheng Zhang,2 Yan Jiang1 1Department of Otorhinolaryngology, 2Key Laboratory of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University, Qingdao, China Introduction: Epigenetic regulation has been shown to play an important role in the development of inflammatory diseases, including chronic rhinosinusitis and nasal polyps. The latter are characterized by epithelial mis-differentiation and infiltration of inflammatory cytokines. H3K4me3 has been shown to be involved in regulating lineage commitment. However, the underlying mechanisms, especially in human nasal epithelial cells (HNEpC, remain underexplored. The objective of this study was to investigate the role of H3K4me3 in HNEpC differentiation treated with the Th2 cytokine IL-13. Patients and methods: The expression levels of mRNA and proteins were investigated using reverse transcription-polymerase chain reaction (RT-PCR assays and Western blot in nasal polyp tissues and human nasal epithelial cells respectively. We measured these levels of H3K4me3, MLL1 and targeted genes compared with control subjects.Results: We demonstrate that expression of H3K4me3 and its methyltransferase MLL1 was significantly upregulated in IL-13-treated HNEpC. This elevation was also observed in nasal polyps. Expression of cilia-related transcription factors FOXJ1 and DNAI2 decreased, while goblet cell-derived genes CLCA1 and MUC5a increased upon IL-13 treatment. Mechanistically, knockdown of MLL1 restored expression of these four genes induced by IL-13. Conclusion: These findings suggest that H3K4me3 is a critical regulator in control of nasal epithelial cell differentiation. MLL1 may be a potential therapeutic target for nasal inflammatory diseases. Keywords: IL-13, H3K4me3 modification, nasal epithelial cell, differentiation 

Detection of maximum loadability limits and weak buses using Chaotic PSO considering security constraints

International Nuclear Information System (INIS)

Acharjee, P.; Mallick, S.; Thakur, S.S.; Ghoshal, S.P.

2011-01-01

Highlights: → The unique cost function is derived considering practical Security Constraints. → New innovative formulae of PSO parameters are developed for better performance. → The inclusion and implementation of chaos in PSO technique is original and unique. → Weak buses are identified where FACTS devices can be implemented. → The CPSO technique gives the best performance for all the IEEE standard test systems. - Abstract: In the current research chaotic search is used with the optimization technique for solving non-linear complicated power system problems because Chaos can overcome the local optima problem of optimization technique. Power system problem, more specifically voltage stability, is one of the practical examples of non-linear, complex, convex problems. Smart grid, restructured energy system and socio-economic development fetch various uncertain events in power systems and the level of uncertainty increases to a great extent day by day. In this context, analysis of voltage stability is essential. The efficient method to assess the voltage stability is maximum loadability limit (MLL). MLL problem is formulated as a maximization problem considering practical security constraints (SCs). Detection of weak buses is also important for the analysis of power system stability. Both MLL and weak buses are identified by PSO methods and FACTS devices can be applied to the detected weak buses for the improvement of stability. Three particle swarm optimization (PSO) techniques namely General PSO (GPSO), Adaptive PSO (APSO) and Chaotic PSO (CPSO) are presented for the comparative study with obtaining MLL and weak buses under different SCs. In APSO method, PSO-parameters are made adaptive with the problem and chaos is incorporated in CPSO method to obtain reliable convergence and better performances. All three methods are applied on standard IEEE 14 bus, 30 bus, 57 bus and 118 bus test systems to show their comparative computing effectiveness and

Experimental Evaluation of Fuzzy Logic Control of a Flexible Arm Manipulator

Science.gov (United States)

1993-12-09

linki -diag = [M-jinkld"iagI]; M-tipl.diag = O*ones(n 1); for i=2n-, M-tipl-diag(iji) = mtl*l1**2;... end M....tipl-diag(l,l) = mtl*(ohl+Hl)**2; M...M-jink lofC~diagl 1 = O*ones(nl~nl); for i= 2:nl-1,.... forj = i+1:nl,... M- linki -off-diagll(i,j) =(1I2)*ml1*11**2+(n1-j)*mll*11**2;... end end for...i = 2:nl,... M~ linki -off~diagl 1(1,1) =(1/2)*mll*(ohl+Il)*Il+(nl-i)*inil*(ohl+Il)*ll;... end Mjinkl~off..diagllI = MjIinkl~offjLiagl l+MjIinkl_off

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells

DEFF Research Database (Denmark)

Agger, Karl; Miyagi, Satoru; Pedersen, Marianne Terndrup

2016-01-01

Acute myeloid leukemias (AMLs) with a rearrangement of the mixed-linage leukemia (MLL) gene are aggressive hematopoietic malignancies. Here, we explored the feasibility of using the H3K9- and H3K36-specific demethylases Jmjd2/Kdm4 as putative drug targets in MLL-AF9 translocated leukemia. Using...... a mechanism involving removal of H3K9me3 from the promoter of the Il3ra gene. Importantly, ectopic expression of Il3ra in Jmjd2/Kdm4 knockout cells alleviates the requirement of Jmjd2/Kdm4 for the survival of AML cells, showing that Il3ra is a critical downstream target of Jmjd2/Kdm4 in leukemia...

Uue majanduse lätteil / Jaak Valge

Index Scriptorium Estoniae

Valge, Jaak

2003-01-01

Sisemajanduse kogutoodangu mõistest ja arvutusmetoodikast, rahvamajanduse arvepidamise kujunemisest erinevates riikides, elatusmaksumusindeksist (tarbimishinnaindeks) ja rahvastiku elatusaladest. Lisatud tabelid: rahvamajanduslik sissetulek Eestis aastatel 1928-1930 ; tootmisalade puhastoodang aastatel 1929-1938 ; rahvamajanduse kogutoodangu maht turuhindades (miljonites 1960. a. USA dollarites); rahvamajanduse kogutoodangu maht ühe isiku kohta jooksvates hindades ning tabelid Eesti elatusmaksumusindeksi ja rahvastiku jaotuse kohta elatusalade järgi

Piirid tugevnevad segases maailmas / Kristjan Jaak Kangur

Index Scriptorium Estoniae

Kangur, Kristjan Jaak

2002-01-01

6. Pimedate Ööde Filmifestivalil näidatud filme : Prantsusmaa - Palestiina - Maroko - Saksamaa "Jumalik sekkumine" (režissöör Elia Suleiman), Sloveenia - Saksamaa "Piiri valvur" (režissöör Maja Weiss) ja Austraalia "Eraldustara" (režissöör Phillip Noyce)

Nullist sündinud filmid / Jaak Kilmi

Index Scriptorium Estoniae

Kilmi, Jaak, 1973-

2005-01-01

Sõpruse kinos toimus 1.-6. aprillini "Manifesti filminädal ehk Kuidas nad maailma sündisid", kus näidati TPÜ filmi ja video filmitudengite "Ground Zero" projekti raames valminud lühifilme-kursusetöid. Autor analüüsib eraldi 9 filmi

Vana hea nõukogude kvaliteet / Jaak Kilmi

Index Scriptorium Estoniae

Kilmi, Jaak, 1973-

2002-01-01

SRÜ ja Baltimaade 11. filmifestivalil Anapas programmi "Avatud videoööd" koostaja muleid ja hinnanguid festivalilt. Parima meesnäitleja preemia sai Rain Simmul Nika osa eest Arvo Iho mängufilmis "Karu süda", žürii märkis ära Mark Soosaare 8-minutilise "La Paloma", "Avatud videoööde" peapreemia sai Mikk Ranna "Sääsk ja hobune". Festivali parimaks filmiks kuulutati Igor Minajevi "Kuumaastikud" ("Lunnõje poljanõ"), mille peaosatäitja Alissa Bogart sai parima naisnäitleja preemia

Cannes'is algas viimane vaatus / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Cannes'i filmifestival. Nähtud filmidest : Alejandro Gonzalez Inarritu "Paabel" (peaosas Brad Pitt), belglase Lucas Belvaux' "Nõrgema õigus", prantslase Bruno Dumonti "Flandria sõdalased" ("Flandres"). Filmiturul on Eesti filmidest edukaim "Leiutajateküla Lotte"

Trier ühitab unelmaid reaalsusega / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2000-01-01

Neljanda Pimedate Ööde Filmifestivali avab 3. detsembril Tallinnas Sakala Keskuse suures saalis Lars von Trieri "Pimeduses tantsija" ("Dancer in the Dark"). Filmist räägivad artikli autor ja režissöör ajakirjale Film Comment (5/2000) antud intervjuu kaudu

Cannes'i klassikud - tuntud headuses / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Cannes'i filmifestival. Nähtud filmidest : soomlase Aki Kaurismäki "Agulituled" ("Laitakaupungin valot"), hispaanlase Pedro Almodovari "Volver" ("Naasta"), inglase Ken Loach'i "Kesva heljutab tuul" ("The Wind that Shakes the Barely"), ameeriklase Richard Linklateri "Rämpstoidu rahvas" ("Fast Food Nation")

Kombates elu ja kunsti piire / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2011-01-01

Serbia kunstniku Marina Abramovići loomingu näitus New Yorgi Moodsa Kunsti Muuseumis MoMa 2010. aasta kevadel. Näitus "Art Must Be Beautiful. Marina Abramovići valitud teosed" Tartu Kunstimuuseumis 13. novembrini 2011. Performance-kunsti ajaloost

Kolm debüüti / Jaak Urmet

Index Scriptorium Estoniae

Urmet, Jaak, 1979-

2001-01-01

Arvustus: Afanasjev, Vahur. Kandiline maailm. Tartu : Irboska Teataja Kirjastus, 2000 ; Ehin, Kristiina. Kevad Astrahanis : luuletusi 1992-1999. Tallinn : Huma, 2000 ; Kaldmaa, Jüri. Passioon. Tallinn : Huma, 2000

Ot Kannskogo festivalja kruzhitsja golova / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2008-01-01

Cannes'i 61. filmifestivalist, lähemalt Woody Alleni filmist "Vicky, Cristina, barcelona ja võistlusprogrammi avafilmist "Pimedus" (režissöör Fernando Meirelles). Ka Veiko Õunpuust, kes on saabunud Euroopa talendi auhinda vastu võtma

Norra-Eesti Selts 25 aastat / Jaak Kiviloog

Index Scriptorium Estoniae

Kiviloog, Jaak

2011-01-01

Tutvustatakse Norra-Eesti Seltsi 25. tegevusaasta tähistamiseks välja antud norrakeelset koguteost: Estland og Norge i fortid og nåtid : norsk-estisk forening 25 år. Oslo : Norsk-estisk forening, 2010

Suveprojekt - igalt teatrilt korraga. II / Jaak Allik

Index Scriptorium Estoniae

Allik, Jaak, 1946-

1997-01-01

Anton Hansen Tammsaare - Margus Kasterpalu 'Tõde ja õigus', lavastanud Andres Noormets (Ugala suvelavastus Vargamäel). Charles Dickensi 'Nicholas Nickleby elu ja seiklused', lavastanud Georg Malvius (Eesti Draamateatris)

Paar maitsvat metsamarja eesti filmiajakirjandusloost / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak, 1955-

2009-01-01

Ajalehes Vaba Eesti ilmunud mõningatest filmipublitsistikat ja -kriitikat käsitlevatest artiklitest: Eino Tubin "Abstraktne film" (VE, 1962 nr. 2) ja "Mõte ja meedium" (VE, 1962, nr. 6), Mardi Valgemäe "Cannes'i filmipidustused ja Ingmar Bergman" (VE 1960, nr. 7), Ivo Iliste "Tuhk ja teemant" (VE 1960, nr. 1) ja "Ons armastus võimalik" (VE 1960, nr. 5)

Harri Taliga - sotside uljas luugimees / Jaak Aab

Index Scriptorium Estoniae

Aab, Jaak, 1960-

2006-01-01

Töötajate usaldusisiku seaduse eelnõust ja ametiühingute rollist töötajate huvide kaitsmisel. Kommentaar artiklile: Taliga, Harri. Tankistist minister pistis pea luugist välja // SL Õhtuleht 20. mai 2006, lk. 8. Sama ka Põhjarannik 26. mai 2006, lk. 2 ; Meie Maa 27. mai 2006, lk. 2, pealkiri kujul : Harri Taliga - uljas tankist ; Hiiu Leht 30. mai 2006, lk. 2 ; Nädaline 20. juuni 2006, lk. 3

Ilusad pildid, mis jagavad teadmisi / Jaak Urmet

Index Scriptorium Estoniae

Urmet, Jaak, 1979-

2006-01-01

Rmt.: Koppel, Donald. Ma hoidsin neid sulle: (I saved them for you) : fotosid eestlastest II maailmasõjas 1943-1944. Tartu : Tartu Kõrgem Kunstikool, 2006 ; Tervitusi Haapsalust : postkaarte ja fotosid Rein Meistri ja Läänemaa Muuseumi kogust. Tallinn : Eesti Entsüklopeediakirjastus, 2006 ; Kuldmuna 2004 : Eesti reklaamiauhinnad. Tallinn : ADC Eesti, 2006

Auhindu Eesti noortele filmiautoreile / Jaak Järvine

Index Scriptorium Estoniae

Järvine, Jaak

1999-01-01

Eesti tudengite ja filmiharrastajate edust Varssavis peetud 17. rahvusvahelisel noorte filmifestivalil "Up to 21" ja Venemaal Luugas toimunud 4. rahvusvahelisel lühifilmide festivalil ja 3. noorte filmi-videofoorumil

Söö, joo, vaata filme / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

57. "Berlinale" esimese poole filmidest: Olivier Dahani "Elu on roos" ("La Mome") Edith Piafist, Robert De Niro "Hea karjane" ("The Good Shepherd"), Clint Eastwoodi "Kirjad Iwo Jimalt" ("Letters from Iwo Jima"), Wang Quanani "Tuya abielu", Stefan Ruzowitsky "Võltsijad" ("Die Fälscher")

Stalinismi kolmas laine [1949-55] / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2013-01-01

Pärast märtsiküüditamist. Kodanlike natsionalistide ja formalistide paljastamine. Sotsialistliku teooria venestamine. Kunstnike Liidu "puhastamine". Kunstihariduse tsentraliseerimine. Kunstimuuseumid. Maalikunst.

Kohatu kangelane : Kalevipoeg 1980. aastate eesti maalis = A hero out of place : the figure of Kalevipoeg in Estonian painting of the 1980s / Anu Allas

Index Scriptorium Estoniae

Allas, Anu, 1977-

2010-01-01

Tolle aja eesti kunstis võib täheldada pidevat huvi mütoloogiliste motiivide ja teemade vastu, millest kasvas välja omalaadne rahvusromantiliste sugemetega kunsti laine. Vaadeldakse mõningate Kalevipoja-aineliste, eriti Lembit Sarapuu, Leonhard Lapini ja Jaak Arro maalide näitel ja tolleaegse kunstikriitika toel, kuidas rahvusromantismi esiletõus kajastab oma aja ja koha kultuuri ideoloogilist kriisi, mida iselooustavad erakordsed motiivid, ülepaisutatud tundetoon, eksootika ja kontrastide rohkus

Uued filmid: õiglus, õilsus ja maagiline kiiker / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2011-01-01

Viru keskuse Katusekinos esilinastub 30. juunil Jaak Kilmi ja Kiur Aarma "Mattise martüürium". Lõppesid Eesti-Soome koostööptojekti "Rat King" võtted. Lõpevad Eesti-Läti-Valgevene ühistöö, "Peeter Simmi "Üksiku saare" võtted. Sellel aastal peaksid algama Ain Mäeotsa filmi "Deemonid", Kadri Kõusaare filmi "Euroopa psühho", Hardi Volmeri filmi "Remont" ja Kanadas Tanel Toomi filmi "Black Ice" võtted

Mõtleme veel...

Index Scriptorium Estoniae

2001-01-01

prof. Jaak Leimanni mõtteid TTÜRist. Vastukaja: Zhukova, Alla. Õhku raamatukogus jätkub... // Mente & Manu : Tallinna Tehnikaülikooli ajaleht (2001) 13. märts, lk. 3. Järs, Jüri. Kogudest, teenustest, kvaliteedist, ressurssidest // Mente & Manu : Tallinna Tehnikaülikooli ajaleht (2001) 13. märts, lk. 3. Pikkov, Lui. Kas internet asendab raamatukogu? // Mente & Manu : Tallinna Tehnikaülikooli ajaleht (2001) 20. märts, lk. 4

Ühe suguvõsa kunstnikud Rakvere muuseumis / Odette Kirss

Index Scriptorium Estoniae

Kirss, Odette

1998-01-01

Rakvere muuseumis toimunud Rakvere lähistelt pärit Mölderite-Vommide suguvõsa 13 kunstniku 1932-1998 a. tööde näitusest; lühidalt suguvõsast ja näitusel esindatud kunstnikest: Voldemar Mölder, Helene Mölder, Benita Vomm, August Vomm, Merike Rimm, Ingrid Järve, Indrek Järve, Silja Mölder, Helga-Maiken Hovi, Ants-Erik Vomm, Mai-Reet Järve, Jaak Järve, Toivo Peter Maricq

Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

Index Scriptorium Estoniae

2007-01-01

Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

Matti Haarajoki : ma ei ole likvidaator / Tanel Mazur

Index Scriptorium Estoniae

Mazur, Tanel, 1971-

2007-01-01

Ilmunud ka: Narva Postiljon, 5. apr. 2007, lk. 1,2; Narvskaja Gazeta, 5. apr. 2007, lk. 1,2. Kreenholmi tegevjuht lükkab ümber väite, nagu kavatsetaks Kreenholm sulgeda. Järgmiseks aastaks vähendatakse töötajate arvu ettevõttes umbes 800 inimese võrra. Sotsiaalminister Jaak Aab ja rahvastikuminister Paul-Eerik Rummo vastavad küsimusele, kas Kreenholmi kriis võib ajendada Ida-Virumaal sotsiaalse plahvatuse. Lisa: Ajalugu

Paide gümnaasiumi spordihoone konkurss = Paide Gymnasium Sports Hall Competition / Tiit Trummal

Index Scriptorium Estoniae

Trummal, Tiit, 1954-

2006-01-01

Žürii liige konkursist, võidutöödest. Žürii koosseis. Konkursi tulemused: I preemia - Karli Luik, Ralf Lõoke, Maarja Kask, töö "Täheke"; II - Ott Kadarik, Villem Tomiste, Mihkel Tüür, töö "Unioon"; III - Koit Ojaliiv, Juhan Rohtla, kaasautor Tõnu Laigu, töö "Kivi"; ostupreemia - Lauri Saar, Tõnu Laanemäe, Indrek Järve, Jaak-Adam Looveer (PAIK Arhitektid), töö "Sensei"

Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells

Energy Technology Data Exchange (ETDEWEB)

Thys, Ryan G., E-mail: rthys@wakehealth.edu [Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1016 (United States); Lehman, Christine E., E-mail: clehman@wakehealth.edu [Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1016 (United States); Pierce, Levi C.T., E-mail: Levipierce@gmail.com [Human Longevity, Inc., San Diego, California 92121 (United States); Wang, Yuh-Hwa, E-mail: yw4b@virginia.edu [Department of Biochemistry and Molecular Genetics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908-0733 (United States)

2015-09-15

Highlights: • Environmental/chemotherapeutic agents cause DNA breakage in MLL and CBFB in HSPCs. • Diethylnitrosamine-induced DNA breakage at MLL and CBFB shown for the first time. • Chemical-induced DNA breakage occurs at topoisomerase II cleavage sites. • Chemical-induced DNA breaks display a pattern similar to those in leukemia patients. • Long-term exposures suggested to generate DNA breakage at leukemia-related genes. - Abstract: Hematopoietic stem and progenitor cells (HSPCs) give rise to all of the cells that make up the hematopoietic system in the human body, making their stability and resilience especially important. Damage to these cells can severely impact cell development and has the potential to cause diseases, such as leukemia. Leukemia-causing chromosomal rearrangements have largely been studied in the context of radiation exposure and are formed by a multi-step process, including an initial DNA breakage and fusion of the free DNA ends. However, the mechanism for DNA breakage in patients without previous radiation exposure is unclear. Here, we investigate the role of non-cytotoxic levels of environmental factors, benzene, and diethylnitrosamine (DEN), and chemotherapeutic agents, etoposide, and doxorubicin, in generating DNA breakage at the patient breakpoint hotspots of the MLL and CBFB genes in human HSPCs. These conditions represent exposure to chemicals encountered daily or residual doses from chemotherapeutic drugs. Exposure of HSPCs to non-cytotoxic levels of environmental chemicals or chemotherapeutic agents causes DNA breakage at preferential sites in the human genome, including the leukemia-related genes MLL and CBFB. Though benzene, etoposide, and doxorubicin have previously been linked to leukemia formation, this is the first study to demonstrate a role for DEN in the generation of DNA breakage at leukemia-specific sites. These chemical-induced DNA breakpoints coincide with sites of predicted topoisomerase II cleavage. The

Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells

International Nuclear Information System (INIS)

Thys, Ryan G.; Lehman, Christine E.; Pierce, Levi C.T.; Wang, Yuh-Hwa

2015-01-01

Highlights: • Environmental/chemotherapeutic agents cause DNA breakage in MLL and CBFB in HSPCs. • Diethylnitrosamine-induced DNA breakage at MLL and CBFB shown for the first time. • Chemical-induced DNA breakage occurs at topoisomerase II cleavage sites. • Chemical-induced DNA breaks display a pattern similar to those in leukemia patients. • Long-term exposures suggested to generate DNA breakage at leukemia-related genes. - Abstract: Hematopoietic stem and progenitor cells (HSPCs) give rise to all of the cells that make up the hematopoietic system in the human body, making their stability and resilience especially important. Damage to these cells can severely impact cell development and has the potential to cause diseases, such as leukemia. Leukemia-causing chromosomal rearrangements have largely been studied in the context of radiation exposure and are formed by a multi-step process, including an initial DNA breakage and fusion of the free DNA ends. However, the mechanism for DNA breakage in patients without previous radiation exposure is unclear. Here, we investigate the role of non-cytotoxic levels of environmental factors, benzene, and diethylnitrosamine (DEN), and chemotherapeutic agents, etoposide, and doxorubicin, in generating DNA breakage at the patient breakpoint hotspots of the MLL and CBFB genes in human HSPCs. These conditions represent exposure to chemicals encountered daily or residual doses from chemotherapeutic drugs. Exposure of HSPCs to non-cytotoxic levels of environmental chemicals or chemotherapeutic agents causes DNA breakage at preferential sites in the human genome, including the leukemia-related genes MLL and CBFB. Though benzene, etoposide, and doxorubicin have previously been linked to leukemia formation, this is the first study to demonstrate a role for DEN in the generation of DNA breakage at leukemia-specific sites. These chemical-induced DNA breakpoints coincide with sites of predicted topoisomerase II cleavage. The

Enhancer-associated H3K4 monomethylation by trithorax-related, the drosophila homolog of mammalian MLL3/MLL4

NARCIS (Netherlands)

H.-M. Herz (Hans-Martin); M. Mohan (Man); A.S. Garruss (Alexander); K. Liang (Kaiwei); Y.-H. Takahashi (Yoh-hei); K. Mickey (Kristen); O. Voets (Olaf); C.P. Verrijzer (Peter); A. Shilatifard (Ali)

2012-01-01

textabstractMonomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancers. Although in yeast all H3K4 methylation patterns, including H3K4me1, are

Calidad de agua en la bahía de Huacho 2002

OpenAIRE

Maldonado, Carlos

2012-01-01

En el 2002 cumpliendo con el Programa de Vigilancia en Bahías con Alto Potencial de Contaminación, se realizaron cinco prospecciones en las bahías de Huacho (11°05’S-11°07’S) y Carquín (11°04’S-11°05’S). En las dos bahías, la temperatura promedio anual fue 17,7 °C; el O2 promedio en superficie varió entre 3,5-3,8 mL/L y en fondo entre 1,3-1,7 mL/L. Los fosfatos en Huacho presentaron valores normales, en Carquín excedieron los límites permisibles en la LGA (15,80 μg-at/L, julio), los silicatos...

Kiviõli linnaväljaku avalik arhitektuurivõistlus = Kiviõli town square open architecture competition / Tiit Sild

Index Scriptorium Estoniae

Sild, Tiit, 1977-

2006-01-01

Arhitektuurivõistluse eesmärgist, premeeritud töödest. Tulemused: I preemia - Tiina Skolimowski, Kai Süda, Risto Parve, töö "Figuur", II - Karli Luik, Ralf Lõoke, Maarja Kask (AB Salto), töö "Saarestik", III - Jaak-Adam Looveer, Toomas Paaver, Lauri Saar, Indrek Järve, Tõnu Laanemäe (AB Paik Arhitektid), töö "Mult", ergutuspreemia - Ott Kadarik, Villem Tomiste, Mihkel Tüür, Kaiko Kivi, Krista Saluveer (AB Kosmos), töö "Sammal"

Pöffi lõppedes asume ootama järgmist Pöffi / Kristiina Davidjants

Index Scriptorium Estoniae

Davidjants, Kristiina, 1974-

2007-01-01

Lõppes 11. Pimedate Ööde Filmifestival. EurAsia programmi grand prix läks Türgi filmile "Takva", parim režissöör on Aleksandr Sokurov ("Aleksandra"), parima naisnäitleja auhinna sai Maarja Jakobson ("Sügisball"), parima meesnäitleja auhinna sai Zdenek Sverak ("Tühjad pudelid"), elutööpreemia nukufilmi lavastaja Heino Pars. Parim Eesti film on "Sügisball". Lisaks nimekiri "Pöffi auhinnad" ja Jaak Kilmi kommentaar "Minu lemmik oli "La France"

Siim Nestor soovitab : Wicked Beat. President of Funk. Muuseumiööl. Springz Bashmendil / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2002-01-01

16. mail toimub Emajõe äärses klubis Atlantis Eesti esimene nu-skool breaks õhtu Wicked Beat, kus peaesinejaks on DJ ja produtsent Databass (plaadifirma Freakaboom "juhatuse esimees" Justin Owen). 18. mail house-muusika pidu Tartus muusikagaleriis Damtan Dance. 17. mai ööl Rotermanni soolalaos triod: 1. Riho Sibul, Jaak Sooäär ja Raul Saaremets ning 2. Tõnis Leemets, Robert Jürjendal ja Aivar Tõnso. 17. mail Von Krahlis Dj Dr. Koit

Vikergallup : eesti kirjandus 1999 : [ajakirja Vikerkaar küsitlus

Index Scriptorium Estoniae

2000-01-01

Aut.: Epp Annus, Tõnu Kaalep, Jan Kaus, Vilja Kiisler, Andrus Kivirähk, Valle-Sten Maiste, Hedda Maurer, Anneli Mihkelev, Mihkel Nummert, Aarne Ruben, Olavi Ruitlane, Mihkel Samarüütel, Franȯis Serpent, Karl Martin Sinijärv, Kadri Tüür, Jaak Urmet, Berk Vaher, Andreas Walden, Mart Velsker. 1999. a. parimaks uudisraamatuks tunnistati küsitluse põhjal Jaan Isotamme "Ma olin Johnny B" (Ilmamaa) ja parimaks esikteoseks Kalju Kruusa "Meeleolu" (Erakkond)

Eesti filmid tõid Lätist auhindu

Index Scriptorium Estoniae

2004-01-01

Arsenalsi festivali Balti võistlusprogrammis osalenud Sulev Keeduse "Somnambuul" võitis parima Balti mängufilmi tiitli ja 2000 USA dollarit. Jaak Kilmi-Rene Reinumäe "Sigade revolutsioon" sai Vienna Laboratory eripreemia. Laila Pakalnina kolme Balti riigi ja Soome ühistööna valminud "Buss" võitis nii parima Balti filmi kui ka parima Balti dokumentaalfilmi tiitli. Festivali grand prix' sai Kanada režissööri Guy Maddini film "The Saddest Music in the World"

Ma tean, mida sa näitad end olevat teinud läinud suvel / Laura Kuusk

Index Scriptorium Estoniae

Kuusk, Laura, 1982-

2006-01-01

Kuraator Marco Laimre juhendamisel valminud Eesti Kunstiakadeemia III kursuse fotograafiaüliõpilaste suvepraktika tööde näitus "Ma tean, mida sa tegid läinud suvel / I know what you did last summer" Eesti Kunstiakadeemia galeriis kuni 3. X. Helina Kõrmi, Dmitri Gerassimovi, Kristjan-Jaak Tammiksaare, Anne-Mai Pällo, Tuuli Antsovi, Terje Ugandi, Ivar Veermäe, Riika Tauriaineni, Kätly Kaibaldi, Raul Viitungi ja Andrus Kaursoni töödest

PENGARUH JAMUR Gliocladium sp. DAN BAKTERI Pseudomonas fluorencens DALAM MENEKAN PERKEMBANGAN PENYAKIT LAYU FUSARIUM PADA TANAMAN PISANG MAS (Musa Paradisiaca L. HASIL KULTUR INVITRO

Directory of Open Access Journals (Sweden)

Etti Siti Hikmawati

2015-12-01

Full Text Available The objective of the study is to determine the potence of natural agent, a mmushroom of Gliocladium sp. and bacterium Peudomonas fluorencens in resisting against the withering disease (Fusarium Oxysporum f.sp. Cubense and their effect to the growth of the in-vitro cultured banana plant (Musa paradisiaca L. Thiswas conducted in the experimental farm of Agriculture Faculty, University of Muhammadiyah Purwokerto, in the period of June to December 2013. This research is a single experiment using Randomized Completely Block Design. The treatment was the administration of Gliocladium sp. In three different doses of 10 g/polybag (G1,20 g/ polybag (G2, 30 g/ polybag (G3, and the giving of Pseudomonas fluorencens in three different dosage of10 ml/l water/ polybag (PF1,20 ml/l water/polybag (PF2 and 30 ml/l water/polybag(PF3 and one control group of no treatment (K0. Based on the result of data analysis, it is proved that the treatment of natural agents of Gliocladiumsp and Pseudomonas fluorencenshas induced the plants resistance against the withering disease of FusariumOxysporumf.sp. Cubense in the banana, as it is indicated by the increase of phenol compounds, i.e. glychoseda, saponin, and thanin. However, the treatment has no significant effect on the plant growth either on their leaves or their stalk diameter.

Removal of Nitrate by Zero Valent Iron in the Presence of H2O2

Directory of Open Access Journals (Sweden)

M.R. Samarghandi

2014-01-01

Full Text Available Background & Aims: Nitrate is the oxidation state of nitrogen compounds, which is founded in water resources that contaminated by municipal, industrial and agricultural waste water. If nitrate leek in to ground water resources, it can cause health problems. Material and Methods: Removal of nitrate from ground water by iron powder in the presence of H2O2 was investigated. Experiments have been done by use of 250 ml of water samples containing 100 mg/L nitrate in various condition. Various parameters such as pH (3, 5, 7, 9, iron dosage (10, 15, 20, 30 g/L, initial H2O2 concentration (5, 10, 15, 20 ml/L and contact time (10-120 min. Results: Obtained results shows the removal of nitrate was increased by pH reduction, increment of iron mass and contact time. In addition, nitrate reduction was increased by increment of initial H2O2 concentration up to 15 ml/L. High removal was observed at pH=3, iron mass=30 g/L, contact time equal 120 min and H2O2 concentration=15 ml/L. At above condition, upon 98% of nitrate was removed. Conclusion: In summary, this method is simple, low cost and effective for removal of nitrate from ground water and industrial activity.

Conformational Ensembles of an Intrinsically Disordered Protein pKID with and without a KIX Domain in Explicit Solvent Investigated by All-Atom Multicanonical Molecular Dynamics

Directory of Open Access Journals (Sweden)

Haruki Nakamura

2012-02-01

Full Text Available The phosphorylated kinase-inducible activation domain (pKID adopts a helix–loop–helix structure upon binding to its partner KIX, although it is unstructured in the unbound state. The N-terminal and C-terminal regions of pKID, which adopt helices in the complex, are called, respectively, αA and αB. We performed all-atom multicanonical molecular dynamics simulations of pKID with and without KIX in explicit solvents to generate conformational ensembles. Although the unbound pKID was disordered overall, αA and αB exhibited a nascent helix propensity; the propensity of αA was stronger than that of αB, which agrees with experimental results. In the bound state, the free-energy landscape of αB involved two low free-energy fractions: native-like and non-native fractions. This result suggests that αB folds according to the induced-fit mechanism. The αB-helix direction was well aligned as in the NMR complex structure, although the αA helix exhibited high flexibility. These results also agree quantitatively with experimental observations. We have detected that the αB helix can bind to another site of KIX, to which another protein MLL also binds with the adopting helix. Consequently, MLL can facilitate pKID binding to the pKID-binding site by blocking the MLL-binding site. This also supports experimentally obtained results.

Prevalence of Gene Rearrangements in Mexican Children with Acute Lymphoblastic Leukemia: A Population Study—Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Science.gov (United States)

Bekker-Méndez, Vilma Carolina; Miranda-Peralta, Enrique; Núñez-Enríquez, Juan Carlos; Olarte-Carrillo, Irma; Guerra-Castillo, Francisco Xavier; Pompa-Mera, Ericka Nelly; Ocaña-Mondragón, Alicia; Bernáldez-Ríos, Roberto; Medina-Sanson, Aurora; Jiménez-Hernández, Elva; Amador-Sánchez, Raquel; Peñaloza-González, José Gabriel; de Diego Flores-Chapa, José; Fajardo-Gutiérrez, Arturo; Flores-Lujano, Janet; Rodríguez-Zepeda, María del Carmen; Dorantes-Acosta, Elisa María; Bolea-Murga, Victoria; Núñez-Villegas, Nancy; Velázquez-Aviña, Martha Margarita; Torres-Nava, José Refugio; Reyes-Zepeda, Nancy Carolina; González-Bonilla, Cesar; Mejía-Aranguré, Juan Manuel

2014-01-01

Mexico has one of the highest incidences of childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is the high prevalence of gene rearrangements associated with the etiology or with a poor prognosis of childhood acute lymphoblastic leukemia (ALL). The aims of this multicenter study were to determine the prevalence of the four most common gene rearrangements [ETV6-RUNX1, TCF3-PBX1, BCR-ABL1, and MLL rearrangements] and to explore their relationship with mortality rates during the first year of treatment in ALL children from Mexico City. Patients were recruited from eight public hospitals during 2010–2012. A total of 282 bone marrow samples were obtained at each child's diagnosis for screening by conventional and multiplex reverse transcription polymerase chain reaction to determine the gene rearrangements. Gene rearrangements were detected in 50 (17.7%) patients. ETV6-RUNX1 was detected in 21 (7.4%) patients, TCF3-PBX1 in 20 (7.1%) patients, BCR-ABL1 in 5 (1.8%) patients, and MLL rearrangements in 4 (1.4%) patients. The earliest deaths occurred at months 1, 2, and 3 after diagnosis in patients with MLL, ETV6-RUNX1, and BCR-ABL1 gene rearrangements, respectively. Gene rearrangements could be related to the aggressiveness of leukemia observed in Mexican children. PMID:25692130

Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair.

Science.gov (United States)

Mian, Elisabeth; Wiesmüller, Lisa

2017-01-01

Ataxia telangiectasia mutated (ATM) encodes a serine/threonine protein kinase, which is involved in various regulatory processes in mammalian cells. Its best-known role is apical activation of the DNA damage response following generation of DNA double-strand breaks (DSBs). When DSBs appear, sensor and mediator proteins are recruited, activating transducers such as ATM, which in turn relay a widespread signal to a multitude of downstream effectors. ATM mutation causes Ataxia telangiectasia (AT), whereby the disease phenotype shows differing characteristics depending on the underlying ATM mutation. However, all phenotypes share progressive neurodegeneration and marked predisposition to malignancies at the organismal level and sensitivity to ionizing radiation and chromosome aberrations at the cellular level. Expression and localization of the ATM protein can be determined via western blotting and immunofluorescence microscopy; however, detection of subtle alterations such as resulting from amino acid exchanges rather than truncating mutations requires functional testing. Previous studies on the role of ATM in DSB repair, which connects with radiosensitivity and chromosomal stability, gave at first sight contradictory results. To systematically explore the effects of clinically relevant ATM mutations on DSB repair, we engaged a series of lymphoblastoid cell lines (LCLs) derived from AT patients and controls. To examine DSB repair both in a quantitative and qualitative manners, we used an EGFP-based assay comprising different substrates for distinct DSB repair mechanisms. In this way, we demonstrated that particular signaling defects caused by individual ATM mutations led to specific DSB repair phenotypes. To explore the impact of ATM on carcinogenic chromosomal aberrations, we monitored chromosomal breakage at a breakpoint cluster region hotspot within the MLL gene that has been associated with therapy-related leukemia. PCR-based MLL-breakage analysis of HeLa cells

Influence of initial L-asparagine and glycerol concentrations on the batch growth kinetics of Mycobacterium bovis BCG Influência das concentrações iniciais de asparagina e glicerol sobre a cinética de crescimento submerso de Mycobacterium bovis

Directory of Open Access Journals (Sweden)

Maria Betania Batista Leal

2004-12-01

Full Text Available The influences of the L-asparagine and glycerol initial concentrations in Sauton medium on the productivities of biomass and colony forming units were studied. The submerged batch cultivations of Mycobacterium bovis were carried out in a 20 L bioreactor. The L-asparagine and glycerol initial concentrations of 4.54 g/L and 25 mL/L, respectively, corresponded to the best biomass productivity, namely 2.5 g/L.day. On the other hand, the concentrations of 2.27 g/L and 25 mL/L, respectively, led to the highest productivity in terms of colony forming units, namely 2.7·10(6 colonies/mg.day. In addition, by means of the relative consumption analysis of L-asparagine and glycerol (50 and 26% respectively, it was concluded that the concentrations of such components could be reduced, with respect to the original Sauton medium composition, aiming the obtainment of an optimal BCG vaccine production in the bioreactor.Estudou-se a influência das concentrações iniciais, no meio de Sauton, de asparagina e glicerol sobre as produtividades, expressas em unidades formadoras de colônias e biomassa microbiana, referentes aos cultivos submersos do Mycobacterium bovis, em biorreator de 20 mL. As concentrações iniciais de 2,27 e 25 mL/L de asparagina e glicerol, respectivamente, conduziram à maior produtividade, em unidades formadoras de colônias, a saber 2,7.10(6 colônias/mg.dia. Por outro lado, as concentrações de 4,54 e 25 mL/L dos mesmos componentes, corresponderam à melhor produtividade em biomassa, a saber: 2,5 g/dia. Através das análises dos consumos relativos de asparagina e glicerol (50 e 26% respectivamente, verificou-se também que as concentrações destes componentes podem ser reduzidas na composição original do meio de Sauton, com o objetivo de obter uma produção otimizada de vacina BCG em bioreator.

The NSLS-II Multilayer Laue Lens Deposition System

International Nuclear Information System (INIS)

Conley, R.; Bouet, N.; Biancarosa, J.; Shen, Q.; Boas, L.; Feraca, J.; Rosenbaum, L.

2009-01-01

The NSLS-II(1) program has a requirement for an unprecedented level of x-ray nanofocusing and has selected the wedged multilayer Laue lens(2,3) (MLL) as the optic of choice to meet this goal. In order to fabricate the MLL a deposition system is required that is capable of depositing depth-graded and laterally-graded multilayers with precise thickness control over many thousands of layers, with total film growth in one run up to 100 m thick or greater. This machine design expounds on the positive features of a rotary deposition system(4) constructed previously for MLLs and will contain multiple stationary, horizontally-oriented magnetron sources where a transport will move a substrate back and forth in a linear fashion over shaped apertures at well-defined velocities to affect a multilayer coating.

Controle da antracnose na pós-colheita de bananas-'prata' com produtos alternativos aos agrotóxicos convencionais Postharvest control of antracnose in 'prata' bananas with alternatives products to conventional pesticides

Directory of Open Access Journals (Sweden)

Ricardo José Zimmermann de Negreiros

2013-03-01

Full Text Available Produtos alternativos aos agrotóxicos convencionais foram avaliados no controle da antracnose causada por Colletotrichum musae em pós-colheita de bananas 'Prata' [Musa spp. (AAB]. Foram utilizados buquês com três frutos, com diâmetro médio de 32 mm a 36 mm, no estádio pré-climatérico, com coloração de casca totalmente verde. Os frutos foram pulverizados com uma suspensão de conídios de C. musae, na concentração de 2,5x10(5 conídios/mL e mantidos em câmara úmida a 25 ºC, por 24 horas. Após esse período, foram pulverizados com as caldas dos produtos alternativos extrato cítrico 'Biogermex', óleo de nim 'Organic Neem' e óleo de alho 'Probinatu', na concentração de 10,0 mL/L, óleo de pimenta-longa e óleo de cravo-da-índia na concentração de 5,0 mL/L e quitosana na concentração de 10,0 mg/mL, além do fungicida Tectoï SC (tiabendazol na concentração de 0,65 mL/L. Água destilada foi utilizada como tratamento-testemunha. Os frutos tratados com quitosana, óleo de nim e óleo de alho tiveram a severidade da doença reduzida. O óleo de alho foi o produto mais eficiente, com redução também da incidência da doença. A qualidade dos frutos não foi depreciada por nenhum dos tratamentos alternativos nas concentrações utilizadas.Alternatives products to conventional pesticides in the control of anthracnose caused by Colletotrichum musae after harvest of 'Prata' banana [Musa spp. (AAB] were evaluated. Fruits with an average diameter of 32-36 mm were selected at the pre-climacteric stage, with a peel color index of 1 (totally green peel. Hands were subdivided into clusters of three fruits. The fruits were sprayed with a conidial suspension of C. musae at a concentration of 2.5 x 10(5 conidia/mL and were kept in a moist chamber at 25°C for 24 hours. After this period, fruits were sprayed with the alternative products 'Biogermex' citric extract, 'Organic Neem' oil and 'Probinatu' garlic oil at a concentration of 10.0 mL/L

Short outlines of books by Estonian authors / Leena Kurvet-Käosaar, Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

2011-01-01

Arvustus: Nurklik, Siim. Kas ma olen nüüd elus. Tallinn : S. Nurklik, 2010 ; Lintrop, Aado. Annapurna. Tartu : Ilmamaa, 2010 ; Lintrop, Aado. Õhtud sõidavad õue. Tartu : Ilmamaa, 2011 ; Saar, Anti. Tekste siledast ruumist. Tallinn : Eesti Keele Sihtasutus, 2009 ; Hvostov, Andrei. Sillamäe passioon. Tartu : Petrone Print, 2011 ; Nõu, Helga. Valetaja. Tallinn : Eesti Ajalehed, 2011 ; Malin, Jaan. Alati vahe. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010 ; Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010

Aukonsulid aitavad edendada kontakte Eestiga / interv. Kalev Vilgats

Index Scriptorium Estoniae

2008-01-01

Ülevaade Eesti aukonsulite viiendast konverentsist, millest võttis osa üle 70 aukonsuli rohkem kui 40 riigist. Lisad: Aukonsulid Eestis; Eesti konsulaatide ajalugu. Vt. samas: Kuidas sai teist Eesti aukonsul? Kui palju kulub teie ajast konsulitööle?; Mida arvavad teie tegevusest perekonnaliikmed ja sõbrad? Küsimustele vastavad Eesti aukonsul Moldovas Igor Goncearov, Eesti aukonsul Los Angeleses Jaak Treiman, Eesti aukonsul Tuneesias Abdeljelil Bouraoui, Eesti peaukonsul Sao Paulos Jüri Saukas. Arvamust avaldab ka Eesti välisminister Urmas Paet.

Thin Films for X-ray Optics

Science.gov (United States)

Conley, Raymond

Focusing x-rays with refraction requires an entire array of lens instead of a single element, each contributing a minute amount of focusing to the system. In contrast to their visible light counterparts, diffractive optics require a certain depth along the optical axis in order to provide sufficient phase shift. Mirrors reflect only at very shallow angles. In order to increase the angle of incidence, contribution from constructive interference within many layers needs to be collected. This requires a multilayer coating. Thin films have become a central ingredient for many x-ray optics due to the ease of which material composition and thickness can be controlled. Chapter 1 starts with a short introduction and survey of the field of x-ray optics. This begins with an explanation of reflective multilayers. Focusing optics are presented next, including mirrors, zone plates, refractive lenses, and multilayer Laue lens (MLL). The strengths and weaknesses of each "species" of optic are briefly discussed, alongside fabrication issues and the ultimate performance for each. Practical considerations on the use of thin-films for x-ray optics fabrication span a wide array of topics including material systems selection and instrumentation design. Sputter deposition is utilized exclusively for the work included herein because this method of thin-film deposition allows a wide array of deposition parameters to be controlled. This chapter also includes a short description of two deposition systems I have designed. Chapter 2 covers a small sampling of some of my work on reflective multilayers, and outlines two of the deposition systems I have designed and built at the Advanced Photon Source. A three-stripe double multilayer monochromator is presented as a case study in order to detail specifications, fabrication, and performance of this prolific breed of x-ray optics. The APS Rotary Deposition System was the first deposition system in the world designed specifically for multilayer

Eesti väärib paremat / Jaak Aaviksoo

Index Scriptorium Estoniae

Aaviksoo, Jaak, 1954-

2006-01-01

Ilmunud ka: Virumaa Teataja, Põhjarannik, Severnoje Poberezhje, Meie Maa, Vooremaa 3. okt. lk. 11,2,2,2,2, Sakala, Pärnu Postimees, Sõnumitooja 4. okt. lk. 2,15,2, Lõunaleht 5. okt. lk. 2, Kuulutaja, Vali Uudised 6. okt. lk. 6,2, Järva Teataja 7. okt. lk. 2. Autori sõnul on Eestis tajutav usalduskriis, mille põhjuseks on eetiliste piiride kadumine meie poliitilistest otsustest. Ta toob välja kolm arenguprioriteeti riigi edasiseks arenguks

Keskerakondlik hävitustöö / Jaak Juske

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Juske, Jaak, 1976-

2007-01-01

Ilmunud ka: Põhjarannik, 7. märts 2007, lk. 2; Järva Teataja, 8. märts 2007, lk. 2; Nädaline, 8. märts 2007, lk. 4; Sakala, 8. märts 2007, lk. 2; Virumaa Teataja, 8. märts 2007, lk. 11; SL Õhtuleht, 8. märts 2007, lk. 12; Harjumaa, 9. märts 2007, lk. 2; Vali Uudised, 9. märts 2007, lk. 2; Lääne Elu, 10. märts 2007, lk. 2. Tallinna linnavolikogu SDE juhi sõnul jäävad Sakala keskuse varemed sümboliseerima keskerakondlikku kultuuripoliitikat

Kui nuustakulased Berliinis käisid / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2007-01-01

57. Berliini filmifestivali peaauhinna Kuldkaru sai Hiina režissööri Wang Quanani film "Tuya abielu" ("Tuya de hun shi"). Ka teistest auhinnasaajatest. Kokkuvõte festivalist ja eestlastest festivalil

Jaak Adamson - ainuke Eesti kodanik Slovakkias / Anneli Ammas

Index Scriptorium Estoniae

Ammas, Anneli, 1962-

2003-01-01

Maalikunstnik lahkus Eestist 23 aastat tagasi. Elab Alam-Tatrates väikeses külakeses. Kastellaanimaja galerii näitus "Lahtilagunemine. Lennufragmendid" on inspireeritud Slovakkia eraldumisest Tšehhi küljest

Sügavast kurgust peegeldub terve ajastu / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

Dokumentaalfilm "Sügavas kurgus" ("Inside Deep Throat") : režissöörid Fenton Bailey, Randy Barbato : Ameerika Ühendriigid 2005. Film käsitleb 1972.a. kurikuulsa pornofilmi "Sügav kurk" ("Deep Throat") fenomeni

Füüsikute aasta / Jaan Aarik, Jaak Kikas

Index Scriptorium Estoniae

Aarik, Jaan, 1951-

2014-01-01

2014. aasta Nobeli füüsikapreemia pälvisid Jaapani teadlased efektiivsete sinist valgust kiirgavate valgusdioodide eest, Nobeli keemiapreemia pälvisid ühiselt sakslane ning ameeriklased ülilahutusega fluorestsents mikroskoopia arendamise eest

Iidamast ja Aadamast ehk "Ahvide planeet" / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2001-01-01

Taas on ekraanile jõudnud Pierre Boulle'i raamatu ainetel "Ahvide planeet" ("Planet of the Apes") : režissöör Tim Burton : Ameerika Ühendriigid 2001. Autor võrdleb seda 1968.a. filmiga ning Ain Kaalepi näidendiga "Iidamast ja Aadamast"

Saalomon ja Raul / Jaak Jõerüüt

Index Scriptorium Estoniae

Jõerüüt, Jaak, 1947-

2010-01-01

Raul Meele näitus Genti ülikooli raamatukogus 20.04.- 28.05.2010. Kunstniku kunstnikuraamat üheteistkümnes keeles: Meel, Raul. Salomon's Song of Songs = Saalomoni Ülemlaul / kujundanud Tiit Jürna. Tallinn, 2010