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Sample records for isosorbide dinitrate tc-99m

  1. Comparison of exercise-rest-reinjection Tl-201 imaging and rest sublingual isosorbide dinitrate Tc-99m MIBI imaging for the assessment of myocardial viability.

    Science.gov (United States)

    Günel, Seval Erhamamci; Akgun, Ayşegul

    2009-07-01

    Nitrate administration has been proposed to enhance the detection of myocardial viability when performing myocardial perfusion imaging. In this study, we aimed to compare Tl-201 exercise-rest-reinjection protocol with rest isosorbide dinitrate (ISDN)-Tc99m MIBI study in the same population examined for the myocardial viability. Twenty-six patients with coronary artery disease who had fixed segmental defects on exercise-rest-Tl-201 imaging were studied. All of them underwent Tl-201 reinjection study. Within 1 week of Tl-201 imaging, rest-Tc99m MIBI imaging was performed after sublingual 5 mg ISDN administration (2-day protocol). For each study, tomograms were divided into 20 segments based on three short-axis slices, one vertical long-axis representing the totality of the left ventricle and regional tracer uptake was quantitatively analyzed. Regional tracer uptake was evaluated in 20 myocardial segments for all patients. Viability was defined as presence of tracer uptake >/=50% of peak activity on each study. A total 520 myocardial segments were assessed by semi quantitative analysis. On the baseline rest Tl-201 studies, 211 segments of the 520 segments that were analyzed had Tl-201 imaging and 55 segments (27%) described as viable on the rest ISDN-Tc99m MIBI imaging. There was 89% concordance between the ISDN-Tc99m MIBI study and Tl-201 reinjection study regarding viable myocardial segments. Of the 23 segments with discordant results, 18 were irreversible on Tl-201 reinjection study, but showed >/=50% uptake on ISDN-Tc99m MIBI. Observation of good agreement between Tl-201 reinjection and ISDN-Tc99m MIBI study studies led us to suggest the use of ISDN enhanced imaging in the evaluation of myocardial viability.

  2. Buccoadhesive drug delivery system of isosorbide dinitrate: Formulation and evaluation

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    Doijad R

    2006-01-01

    Full Text Available Buccoadhesive buccal delivery systems for isosorbide dinitrate in the form of unidirectional buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like Carbopol 934P and polyvinyl pyrrolidone by using two different plasticizers propylene glycol and diethyl phthalate. Unidirectional release was achieved by preparing composite films with backing membrane. The films were characterized on the basis of their physical characteristics, bioadhesive performance, and other parameters. In vitro studies revealed that release rate of isosorbide dinitrate was higher from carbopol films containing ratio of Eudragit RL100 and polyvinyl pyrrolidine in proportion of 1:2 and 2:1, respectively by using both plasticizers. Drug diffusion from buccal films showed apparently zero order kinetics and release mechanism was diffusion controlled after considerable swelling. All the films exhibited sufficient in vitro bioadhesion strength. Promising formulations were further studied for temperature dependent stability studies. Results of our preliminary experiments indicate that, therapeutic level of isosorbide dinitrate can be achieved using this buccaladhesive formulation.

  3. Comparative study between the use of isosorbide dinitrate and captopril in hypertensive emergency treatment.

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    Brandy Viera Valdés

    2005-04-01

    Full Text Available Fundament: Oral antihypertensive drugs are lacking in our environment at present in tog hypertensive urgencies, that is why new therapeutic alternatives are necessary to treat this medical problem. Objective: To assess the effect of Isosorbide Dinitrate in the treatment of hypertensive urgencies the system of urgencies. Method: a cuasi experimental study was designed with 60 patients with this diagnosis. The patients were divided into two groups. The patients of one group received treatment for the hypertensive crisis with Isosorbide Dinitrate 10 mg sub lingually and the others had their treatment with Captopril 25 mg p.o. Results: The response of the treatment with Isosorbide Dinitrate with similar to the treatment with Captopril. High Blood Pressure was controlled in 66,6 % with Isosorbide Dinitrate and in 73,3 % with Captopril, with few effects for both medications. Conclusions: Results were similar in this search with the use of Isosorbide Dinitrate and other antihypertensive drugs in the treatment of hypertensive urgencies . In the future, with the appearance of new evidencies Isosorbide Dinitrate could be used as an alternative in the treatment of hypertension at the urgency department when there is no possibility for applying any other medication.

  4. Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.

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    Gomita,Yutaka

    1990-02-01

    Full Text Available The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lower in stressed rats than in non-stressed rats, suggesting that stress may influence the metabolism and/or excretion of the metabolites.

  5. Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

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    Cossu MV

    2014-05-01

    Full Text Available Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco”, Università di Milano, Milan, Italy; 2Unit of Infectious Diseases, University Hospital “Luigi Sacco”, Milan, Italy; 3Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy Abstract: We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs’ efficacy in patients affected by Duchenne muscular dystrophy. For the first trial, ISOFEN1, a single-dose, randomized-sequence, open-label, active control, three-treatment cross-over study, was aimed at comparing the pharmacokinetics of ibuprofen 200 mg and isosorbide dinitrate 20 mg when given alone and concomitantly. The pharmacokinetics of ibuprofen given alone versus ibuprofen given concomitantly with isosorbide dinitrate were similar, as documented by the lack of statistically significant differences in the main drug’s pharmacokinetic parameters (time to maximal concentration [Tmax], maximal concentration [Cmax], area under the curve [AUC]0–t, and AUC0–∞. Similarly, we found that the coadministration of ibuprofen did not significantly affect the pharmacokinetics of isosorbide dinitrate. No issues of safety were detected. The second trial, ISOFEN2, was a single-site, dose titration study that was designed to select the maximum tolerated dose for isosorbide dinitrate when coadministered with ibuprofen. Eighteen out of the 19 enrolled subjects tolerated the treatment well, and

  6. Effects of bisoprolol and isosorbide dinitrate on the circadian distribution of myocardial ischemia

    NARCIS (Netherlands)

    Portegies, MCM; Brouwer, J; Ven, LLMVD; Viersma, JW; Lie, KI

    1995-01-01

    The effects of bisoprolol 10 mg once daily, isosorbide dinitrate (ISDN) 20 mg three times daily, or a combination of these drugs on ischemia during exercise testing and on the occurrence and the circadian variation of ischemia during ambulatory monitoring were evaluated in 23 patients with stable an

  7. Mismatched uptake of Tc-99m-ECD and Tc-99m-HMPAO in subacute cerebral infarction: Tc-99m-ECD for viability and Tc-99m-HMPAO for flow restoration

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    Lee, D. S.; Hyun, I. Y.; Kim, S. K. [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)] [and others

    1997-07-01

    Tc-99m-HMPAO reflects tissue perfusion but Tc-99m-ECD uptake is affected by tissue viability in addition to tissue perfusion which the varied state of cellular retention of Tc-99m-ECD reflects. Luxuriously perfused area on Tc-99m-HMPAO SPECT implies that this cortex was already reperfused either spontaneously or after thrombolysis and that accompanied paralysis of vascular reactivity in those zones warms progressive deterioration. We tried to find out if we can use sequential Tc-99m-ECD/Tc-99m-HMPAO SPECT to reveal cortical perfusion and severity and range of risky areas of cerbral cortex despite reperfusion in sub-acute infarction. In 13 patients (M ; F =7 : 6, mean age 57 (range: 26-84)) with cortical (n=12) and basal ganglia infarction (1), we performed sequential Tc-99m-ECD/Tc-99m-HMPAO SPECT at the same position. At first, 555 MBq of Tc-99m-ECD was injected and imaged and then 1110 MBq of Tc-99m-HMPAO was injected again and imaged with the patients in situ, and the first image (Tc-99m-ECD) and the subtracted image (2nd- 1st : Tc-99m-HMPAO) were compared slice by slice. Study was done from 3 days to 31 days (16{+-}9) after ictus. Tc-99m-ECD uptake was always less than or equal to Tc-99m-HMPAO uptake at the lesion in all cases. Luxury perfusion was prominent in four patients. Mismatched uptake was found in 10 patients. Severity of mismatch showed diverse spectrum and was ranged from total middle cerebral artery territory (1 case) to peripheral thin zones around infarction (2 cases). The other 7 showed intermediate amount of tissues with mismatch , i.e., Tc-99m-ECD defects where Tc-99m-HMPAO uptake is in part increased, normal or decreased. Upon discharge, patients having more uptake with Tc-99m-ECD predicted improvement. Patients having mismatched uptake went dichotomous way. In conclusion, Tc-99m-ECD/Tc-99m-HMPAO sequential SPECT is feasible and reveal both tissue perfusion (Tc-99m-HMPAO ) and discrepant Tc-99m-ECD uptake probably reflecting viability in acute

  8. Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers.

    Science.gov (United States)

    Cossu, Maria Vittoria; Cattaneo, Dario; Fucile, Serena; Pellegrino, Paolo; Baldelli, Sara; Cozzi, Valeria; Capetti, Amedeo; Clementi, Emilio

    2014-01-01

    We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs' efficacy in patients affected by Duchenne muscular dystrophy. For the first trial, ISOFEN1, a single-dose, randomized-sequence, open-label, active control, three-treatment cross-over study, was aimed at comparing the pharmacokinetics of ibuprofen 200 mg and isosorbide dinitrate 20 mg when given alone and concomitantly. The pharmacokinetics of ibuprofen given alone versus ibuprofen given concomitantly with isosorbide dinitrate were similar, as documented by the lack of statistically significant differences in the main drug's pharmacokinetic parameters (time to maximal concentration [Tmax], maximal concentration [Cmax], area under the curve [AUC]0-t, and AUC0-∞). Similarly, we found that the coadministration of ibuprofen did not significantly affect the pharmacokinetics of isosorbide dinitrate. No issues of safety were detected. The second trial, ISOFEN2, was a single-site, dose titration study that was designed to select the maximum tolerated dose for isosorbide dinitrate when coadministered with ibuprofen. Eighteen out of the 19 enrolled subjects tolerated the treatment well, and they completed the study at the highest dose of isosorbide dinitrate applied (80 mg/day). One subject voluntarily decided to reduce the dose of isosorbide dinitrate from 80 mg to 60 mg. The treatment-related adverse events recorded during the study were, for the large majority, episodes of headache that remitted spontaneously in 0.5-1 hour - a known side effect of isosorbide dinitrate. These studies demonstrate that the combination of isosorbide dinitrate and ibuprofen does not lead to pharmacokinetic interactions between the two drugs; they also

  9. Muscle localization of Tc-99m MDP after exertion

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    Valk, P.

    1984-09-01

    Very high muscle uptake of Tc-99m MDP was seen two days after the start of a program of vigorous weight-lifting exercises. Localization of Tc-99m bone tracer in muscle that has been damaged by exertion may be a more common phenomenon than is recognized at present.

  10. Tc-99m Ciprofloxacin SPECT of Pulmonary Tuberculosis

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    Lee, Min Kyung; Hwang, Kyung Hoon [Gachon University Gil Hospital, Incheon (Korea, Republic of); Yoon, Min Ki [Good Samaritan Hospital, Pohang (Korea, Republic of); Choe, Won Sick [Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

    2010-06-15

    Tc-99m ciprofloxacin is available for imaging infection. However, there has been no study on employing single photon emission computed tomography (SPECT) with using Tc-99m ciprofloxacin to image active pulmonary tuberculosis. Therefore, we conducted this study to assess the efficacy of Tc-99m ciprofloxacin SPECT for imaging active pulmonary tuberculosis. Twenty-one participants were enrolled in this prospective study. They were divided into two groups according to the clinical and radiological assessment. Group one (Gr. 1) consisted of five normal volunteers and six patients with inactive pulmonary tuberculosis. Group two (Gr. 2) consisted of ten patients with active pulmonary tuberculosis. SPECT was performed 3 h after injecting 555 MBq (15 mCi) of Tc-99m ciprofloxacin. The findings of Tc-99m ciprofloxacin SPECT were interpreted by a nuclear medicine specialist and then the results were analyzed according to the patients' clinical and radiological classifications. The results of Tc-99m ciprofloxacin SPECT were as follows: eight true-positive cases, ten true-negative cases, one false-positive case and two false-negative cases. The sensitivity and specificity was 80.0% and 90.0%, respectively. The positive predictive value was 88.9% and the negative predictive value was 83.3%. Conclusions Tc-99m ciprofloxacin SPECT is feasible for imaging active pulmonary tuberculosis. It is a useful nuclear-imaging method for discriminating between the active and inactive tuberculosis states in patients with a past medical history of pulmonary tuberculosis.

  11. Asialoglycoprotein receptor targeted imaging using Tc-99m galactosylated chitosan

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    Kim, E. M.; Jeong, H. J.; Kim, B. C.; Kim, C. K [Wonkang University College of Medicine, Iksan (Korea, Republic of)

    2004-07-01

    The asialoglycoprotein receptor (ASGP-R) is expressed on liver hepatocytes. Chitosan conjugates of galactose have shown to be specifically taken up by liver parenchymal cells via ASGP-R. In this study, Tc-99m hydrazino nicotinamide (HYNIC)-galactosylated chitosan (HYNIC-GC) was synthesized and evaluated as a targeted agent for the imaging of hepatocytes. GC was obtained after coupling of lactobionic acid as the galactose moiety and coupled with HYNIC. HYNIC-GC was radiolabeled with Tc-99m using stannous chloride and tricine as reducing agent and coligand respectively. Hepatic uptake property of Tc-99m HYNIC-GC was studied in female Balb/C mouse. Tc-99m HYNIC--GC and Tc-99m HYNIC-Chitosan as a control were intravenously injected into mice. Receptor binding was identified by coinjection with 50 mM and 80mM free galactose respectively. Biodistribution was determined at three different time points. The level of galactose substitution was 7.6%. Labeling efficiency was >90% both in vitro and serum up to 24 h. Tc-99m HYNIC-GC injected via tail vein of mice showed high selectivity of liver. On the other hands, Tc-99m HC without galactose group showed low uptake (Fig. 1A, 1B). Hepatic uptake of Tc-99m HYNIC-GC was dramatically blocked by 50 mM and 80 mM free galactose coinjection (Fig. 1C, 1D). The liver accumulated about 14 percent injected dose per gram (%ID/g) up to 120 min after injection. Tc-99m HYNIC-GC showed specific and rapid targeting to liver. It is a promising specific radiopharmaceutical with potential applications in the imaging of liver parenchymal cells.

  12. Effect of sustained-release isosorbide dinitrate on post-prandial gastric emptying and gastroduodenal motility in healthy humans

    DEFF Research Database (Denmark)

    Madsen, J L; Rasmussen, S L; Linnet, J

    2004-01-01

    and gastroduodenal motility after a meal. Eleven healthy volunteers participated in a double-blind, placebo-controlled, cross-over study. Each subject ingested 40 mg isosorbide dinitrate orally as a sustained-release formulation or oral placebo, in random order. Gastric emptying and gastroduodenal motility were...... measured using scintigraphic and manometric techniques. Isosorbide dinitrate did not change the area under the curve of gastric retention versus time, and did not influence the frequency of antral contractions as assessed at 15-min intervals or the integrated duodenal motility index, as recorded over...... consecutive 15-min periods. A 40 mg single dose of sustained-released isosorbide dinitrate does not seem to alter gastric emptying or gastroduodenal motility after a meal....

  13. Intra-arterial injection of Tc-99m MDP

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    Ebru Salmanoglu

    2016-03-01

    Full Text Available Bone scintigraphy is applied to evaluate abnormalities of axial skeleton and appendicular skeleton including osteomyelitis, prosthesis infection, prosthesis loosening, avascular necrosis, stress fracture, bone metastasis. Technetium-99m methylene diphosphonate (Tc-99m MDP is most common used radiopharmaceutical. Injection of Tc-99m MDP should be done intravenous but it can be done intra-arterial, accidentally. After intra-arterial injection of Tc-99m MDP, it cause prominent soft tissue uptake distal to the injection site. This situation can create confusion in the scintigraphic images. Usually, it imitate reflex sympathetic dystrophy, so differential diagnosis is important. The aim of this report is to present the appearance of inadvertent intra-arterial injection of Tc-99m MDP. [Cukurova Med J 2016; 41(0.100: 79-82

  14. Poor Tc-99m dimercaptosuccinic acid uptake, re-evaluation with Tc-99m MAG3 scintigraphy in Lowe syndrome

    OpenAIRE

    Koca, Gokhan; Atilgan, Hasan Ikbal; Demirel, Koray; Diri, Akif; KORKMAZ, Meliha

    2011-01-01

    Tc-99m dimercaptosuccinic acid (DMSA) is filtered through the glomeruli and reabsorbed by the proximal tubules as low molecular weight proteins. In Lowe syndrome this mechanism is impaired and so poor DMSA uptake is seen. Poor DMSA uptake was shown in very few studies, but none mentioned normal Tc-99m MAG3 uptake. In this case, the patient had poor DMSA uptake, normal MAG3 uptake and a neurogenic bladder in anterior to the left kidney that attenuates left kidney.

  15. Effect of sustained-release isosorbide dinitrate on post-prandial gastric emptying and gastroduodenal motility in healthy humans

    DEFF Research Database (Denmark)

    Madsen, Jan Lysgård; Rasmussen, S L; Linnet, J;

    2004-01-01

    measured using scintigraphic and manometric techniques. Isosorbide dinitrate did not change the area under the curve of gastric retention versus time, and did not influence the frequency of antral contractions as assessed at 15-min intervals or the integrated duodenal motility index, as recorded over...

  16. Influence of endothelium in dose-dependent inhibition and potentiation by isoniazid of isosorbide dinitrate relaxation of rat aorta.

    Science.gov (United States)

    Vidrio, H; Fernández, G

    2001-05-01

    The influence of in vivo administration of isoniazid on the relaxant effect of isosorbide dinitrate was determined by pretreating rats with various doses of isoniazid and obtaining concentration-response curves to isosorbide dinitrate in aortic rings from these animals. In rings with endothelium, isoniazid potentiated responses to isosorbide dinitrate at doses of 10, 30, and 100 mg/kg; 3 and 300 mg/kg were without effect. In endothelium-denuded preparations, potentiation was present only at 10 mg/kg; 3 and 300 mg/kg inhibited relaxation. Other experiments indicated that isoniazid potentiation was prevented by pyridoxine, was reproduced with theophylline, and did not occur with 3-morpholinosydnonimine or papaverine. These results were deemed compatible with the hypothesis that isoniazid inhibits transsulfuration of homocysteine and causes its accumulation in vascular smooth muscle and endothelial cells, where it functions as a thiol intermediate and leads to enhanced bioactivation of isosorbide dinitrate. Potentiation appeared to occur only with moderate increases of homocysteine.

  17. Gastric Reflux on Routine Tc-99m DISIDA hepatobiliary Scintigraphy

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    Lee, Kang Wook; Lee, Heon Young [Chungnam National University College of Medicine, Daejeon (Korea, Republic of)

    1995-06-15

    Reflux of bile and digestive enzymes from the small bowel and duodenum into stomach has been observed in patients with various gastroduodenal diseases. Tc-99m iminodiacetic acid derivatives hepatobiliary scan has been used as a noninvasive method to detect duodenogastric reflux. Sometimes, gastric reflux can be observed incidentally on routine Tc-99m DISA hepatobiliary scintigraphy. To evaluate the clinical meaning of gastric reflux on routine Tc-99m DISIDA hepatobiliary scan, we analyzed 36 patients showed gastric reflux incidentally on the routine Tc-99m-DISIDA hepatobiliary scintigraphy from December 1991 to June 1995 in Chungnam National University Hospital. The results were as follows: 1) The gastric reflux was observed in 2.3% of 1,553 cases of routine Tc-99m DISIDA Hepatobiliary scintigraphy for 43 months. 2) Nineteen percent of patients with gastric reflux had the past medical history of operations on stomach or biliary system. And that history was more prevalent in patients with reflux than those without reflux, significantly (p<0.01). 3) On fiberoptic gastroduodenpscopic examination, 87% of the patients with gastric reflux had the gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer, duodenal cancer and ampullary diverticulosis. We thought that the gastric reflux can be observed considerably in patients without any operation history on stomach or duodenum, although the operation history is more prevalent in patients with gastric reflux than those without reflux, significantly and most of patients with gastric reflux on routine Tc-99m DISIDA scan has various gastroduodenal diseases.

  18. Detection of melanoma metastases with Tc-99m-tetrofosmin; Nachweis von Melanommetastasen mit Tc-99m-Tetrofosmin

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    Rettenbacher, L.; Kaessmann, H.; Galvan, G. [Inst. fuer Nuklearmedizin und Endokrinologie, Landeskrankenanstalten Salzburg (Austria); Koller, J. [Abt. fuer Dermatologie, Landeskrankenanstalten Salzburg (Austria)

    2000-06-01

    Aim: The aim of this study was to evaluate Tc-99m-tetrofosmin whole-body imaging in the detection of metastases in patients with malignant melanoma. Methods: In 30 patients with suspected melanoma metastases we performed whole body imaging. After administration of about 600 MBq Tc-99m-tetrofosmin dynamic images up to 10 min were performed in 7 patients (1 image per 10 sec) to evaluate the optimal tracer uptake in the metastases. In all patients whole-body images were performed 5-10 min p.i. using an acquisition time of 5 min per image. The final diagnosis was confirmed by surgical histology in 30 lesions, by computertomography and clinical course in the remaining lesions. Results: Out of 64 melanoma metastases 49 were detected using Tc-99m-tetrofosmin scintigraphy (49 rp., 15 fn.). The overall sensitivity for the detection of malignant lesions was 77%. Referring only to the lymph node metastases, the sensitivity was 87% (26 rp; 4fn.). The maximal tracer uptake was reached 1 min after injection, with a slow decrease in the following 10 minutes. The size of the lesions ranged between 0.5 and 7.0 cm and the T/B ratios between 1.3 and 3.0 (mean 1.88). Conclusions: Tc-99m-tetrofosmin whole body imaging is a simple and side-effect-less method for the detection of melanoma metastases especially of lymph node metastases. The results are comparable to Tc-99m-sestamibi and Tl-201 scintigraphy. (orig.) [German] Ziel: Ziel dieser Studie war es, festzustellen, wieweit sich die Tc-99m-Tetrofosminszintigraphie zum Nachweis von Melanommetastasen eignet. Methoden: Bei 30 Patienten mit suspekten Melanommetastasen wurde eine Tc-99m-Tetrofosmin Ganzkoerperszintigraphie durchgefuehrt. Nach intravenoeser Injektion von 600 MBq Tc-99m-Tetrofosmin erfolgten bei 7 Patienten Sequenzszintigraphien ueber 10 Min. (1 Bild pro 10 Sek.), um den optimalen Traceruptake im Tumor festzustellen und bei allen Patienten Ganzkoerperaufnahmen (Aufnahmebeginn 5-10 min p.i., Aufnahmezeit 5 Min. pro Bild). 30

  19. Tc-99m ciprofioxacin imaging in acute cholecystitis

    Institute of Scientific and Technical Information of China (English)

    Yun-Mee Choe; Kee-Chun Hong; Seok-Hwan Shin; Kyung-Rae Kim; Ze-Hong Woo; Wonsick Choe; Keon-Young Lee; Seung-Ik Ahn; Kwang Kim; Young Up Cho; Sun Keun Choi; Yoon-Seok Hur; Sei-Joong Kim

    2007-01-01

    AIM: To evaluate the efficacy of a new nuclear imaging Infecton (Tc-99m ciprofioxacin) for the diagnosis of acute cholecystitis.METHODS: Sixteen patients thought to have acute cholecystitis were included in this study. The diagnosis of acute cholecystitis was made based on clinical symptoms and ultrasonographic and pathologic findings.RESULTS: The 16 patients were composed of 12 acute and 4 chronic cholecystitis patients. Twelve patients with acute cholecystitis were image-positive, including one false-positive. Four patients with chronic cholecystitis were image-negative, of whom three were true-negative.This nuclear imaging had a sensitivity of 91.7%, a specificity of 75%, a positive-predictive value of 91.7%,and a negative-predictive value of 75%.CONCLUSION: Tc-99m ciprofloxacin imaging is easy to perform and applicable for the diagnosis of acute cholecystitis.

  20. Influence of systemically given placebo, trapidil and isosorbide dinitrate on norepinephrine-evoked hand vein constriction in healthy subjects.

    Science.gov (United States)

    Sziegoleit, Werner; Dannenberg, Katrin; Konschak, Ariana; Lautenschläger, Christine; Presek, Peter

    2007-01-01

    Since trapidil (CAS 15421-84-8) is able to dilate human hand veins after local intravenous administration, four studies were carried out in healthy male volunteers using the dorsal hand vein compliance technique to test the influence of common systemic single doses of trapidil (200 mg orally, 100 mg intravenously) and isosorbide dinitrate (CAS 87-33-2, 20 mg orally) on norepinephrine (CAS 51-41-2)-evoked hand vein constriction in comparison with oral placebo. Oral placebo and oral trapidil were studied in a randomized double-blind cross-over design in 10 subjects aged 20 to 30 years, and oral isosorbide dinitrate and intravenous trapidil, in a randomized open cross-over design in 8 subjects aged 22 to 29 years. In the three similar studies with oral medications dose-response curves for venoconstriction by locally infused norepinephrine were established before and 1 h, 2 h and 3 h after oral medication and ED50 values of norepinephrine were calculated. The control dose-response curves and ED50 values of norepinephrine did not differ significantly. After oral placebo administration the dose-response curves of norepinephrine did not change significantly, but the ED50 of norepinephrine increased 3 h after placebo (from 12.1 to 31.7 ng/ min), indicating a lessening in norepinephrine effect at this time. After oral trapidil application the dose-response curves of norepinephrine shifted to the left compared with the pre-treatment curve (significantly 2 h after trapidil) and the corresponding curves after placebo with a significant decrease in the ED50 of norepinephrine 3 h after trapidil compared with placebo (from 31.7 to 12.6 ng/ min). After oral isosorbide dinitrate administration the dose-response curves of norepinephrine did not differ significantly from the pre-treatment curve, but they shifted to the left compared with the corresponding curves after placebo (significantly 3 h after isosorbide dinitrate). The ED50 of norephinephrine decreased significantly 2 h after

  1. Sclerosing cholangitis: cholescintigraphy with Tc-99m-labeled DISIDA

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    Ament, A.E.; Bick, R.J.; Miraldi, F.D.; Haaga, J.R.; Wiedenmann, S.D.

    1984-04-01

    Four patients with primary sclerosing cholangitis (PCS) were examined with the hepatobiliary agent Tc-99m-labeled DISIDA (diisopropylphenylcarbamoyl iminodiacetic acid), and the results correlated with those of invasive cholangiography. Cholescintigraphy is superior to cholangiography in cases of suspected PSC where there is nonfilling of biliary radicals due to high-grade stenosis. The finding of delayed hepatic parenchymal clearance can allow estimation of the degree of obstruction of the various branches of the major bile ducts. Cholescintigraphy offers a noninvasive method of investigating patients with suspected sclerosing chloangitis, leading to earlier diagnosis. Confirmation with invasive cholangiographic procedures is recommended.

  2. Hyperfixation of Tc-99m ECD in subacute cortical infarction

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    Kim, Jae Seung; Kweon, Sun Uck; Ryu, Jin Sook; Moon, Dae Hyuk; Lee, Hee Kyung [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    2001-07-01

    It has been known that hyperfixation of Tc-99m ECD (HF) is not shown in subacute cerebral infarction because the brain distribution of Tc-99m ECD reflects not only perfusion but also the metabolic status of brain tissue. However, we observed several cases with HF in the subacute pure cortical infarction. To find out the cause of HF in subacute cortical infarction. We assessed the difference in associated cerebral hemodynamics and clinical findings between the subacute cortical infarctions with and without HF. We reviewed 16 patients (63.8{+-}8.6 yr, M/F: 15/1) with pure cortical infarction not involving adjacent subcortical white matter on MRI. All patients underwent acetazolamide stress brain perfusion SPECT using Tc-99m ECD and MRI at subacute period (7.3{+-}4.4 days from ictus). Uptake of Tc-99m ECD in infarcted cortex was assessed visually comparing the contralateral side. To assess the difference in associate clinical findings between the infarctions with and without HF, rCVR of the cerebral territory including infarcted cortex, extent of Gd-enhancement on MRI. Intervals between SPECT and ictus, and the presence of associated ICA stenosis were evaluated. Infarctions were focal (n=8) or multifocal (n=8) and located in frontoparietal cortices on MRI. Twelve patients were accompanied with ipsilateral ICA stenosis. Resting SPECT showed increased cortical uptake (=HF) in 7 patients and decreased in 9. rCVR of the MCA territory was preserved in all of the 7 patients with HF, compared with 4 of the 9 patients without HF (p=0.03). Gd-enhancement was minimal in all of the 7 patients with HF, compared with of the 0 patients without HF (p=0.03). Presence of ipsilateral ICA stenosis and intervals from ictus were not different (p>0.1) Subacute cerebral cortical infarction with HF was more frequently associated with preserved rCVR and minimal destruction of the blood-brain barrier than that without HF. Our findings suggest that HF may result from luxury perfusion of

  3. Novel Tc-99m radiotracers for brain imaging

    Directory of Open Access Journals (Sweden)

    Alessandra Boschi

    2007-09-01

    Full Text Available A novel class of Tc-99m complexes able to cross the blood brain barrier has been investigated and described here. These compounds are formed by reacting the bis-substituted nitrido precusors [99mTc(N(PS2] (PS = phosphino-thiol ligand with triethylborane (BEt3 under strictly anhydrous conditions and using non-aqueous solvents. The molecular structure of these tracers was not fully established, but preliminary experimental evidence suggests that they result from the interaction of the Lewis base [99mTc(N(PS2] with the Lewis acid BEt3, which leads to the formation of the novel -B-Nº Tc- adduct. After purification and recovery in a physiological solution, the new borane-nitrido Tc-99m derivatives were injected in rats for evaluating their in vivo biological behavior. Results showed a significant accumulation in brain tissue, thus indicating that these complexes are capable of penetrating the intact blood brain barrier. Uptake in the central nervous system was confirmed by imaging the distribution of activity on the integrated living animal using a YAP(SSPECT small animal scanner.Uma nova classe de complexos de Tc-99m capazes de atravessar a barreira hemato-encefálica foi investigada e descrita neste trabalho. Estes compostos são formados reagindo os precursores bissubstituídos do nitrido [99mTc(N(PS2] (PS = phosphino-tiol ligante com trietillborano (BEt3 sob restritas condições anidras e usando solventes não aquosos. A estrutura molecular desses traçadores não foi totalmente estabelecida, mas evidências experimentais preliminares sugerem que eles resultam da interação da base de Lewis [99mTc(N(PS2] com o ácido de Lewis BEt3, levando a formação do novo aducto -B-Nº Tc-. Após purificação e recuperação em uma solução fisiológica, os novos derivados borano-nitrido-Tc-99m foram injetados em ratos para avaliação de seu comportamento biológico in vivo. Os resultados mostraram uma acumulação significativa no tecido cerebral

  4. Comparison of the Efficiency for Tc-99m Tin-colloid and Tc-99m Phytate in Sentinel Node Detection in Breast Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Seok, Ju Won [Chung-Ang University, Seoul (Korea, Republic of); Kim, In Ju [College of Medicine, Pusan National University, Pusan (Korea, Republic of)

    2008-12-15

    Lymphoscintigraphy and sentinel node biopsy has become a standard method for detection of axillary lymph node metastasis in breast cancer patients, but the standard radiopharmaceutical was not prepared. About detection of axillary lymph node metastasis by lymphoscintigraphy and sentinel node biopsy in breast cancer patient, we compared the results of Tc-99m Tin-colloid and Tc-99m Phytate by subareolar injection. This study included 382 breast cancer patients who were performed operation during 2001-2008. Three hundred forty nine patients was injected 0.8 ml of Tc-99m Tin-colloid (37-185 MBq) by subareolar injection. Thirty three patients was injected 0.8 ml of Tc-99m Phytate (37-185 MBq). Lymphoscintigraphy was performed in supine position and sentinel node localization was performed by hand-held gamma probe in operation. Among 349 patients by Tc-99m Tin-colloid, 312 cases (89.4%) localized the sentinel node by lymphoscintigraphy, 304 cases (87.1%) localized by gamma probe. Among 33 patients by Tc-99m Phytate, 32 cases (97.0%) localized by lymphoscintigraphy, 33 cases (100%) localized by gamma probe. Detection rate by lymphoscintigraphy and gamma probe was superior for Tc-99m Phytate compared to that with Tc-99m Tin-colloid, with a statistically significant difference. (p<0.05, p<0.05) Tc-99m Phytate is a better choice for localization of sentinel node than Tc-99m Tin-colloid in breast cancer patients.

  5. Development of Tc-99m Imaging Agents for Abeta Plaques

    Energy Technology Data Exchange (ETDEWEB)

    Zhi-Ping, Zhuang; Mei-Ping Kung; Catherihne Hou; Hank F. Kung

    2008-09-26

    Development of SPECT imaging agents based on Tc-99m targeting Aβ plaques is useful for diagnosis of Alzheimer’s disease (AD). A stilbene derivative, [11C]SB-13, showing promise in detecting senile plaques present in AD patients has been reported previously1,2. Based on the 4’-amino-stilbene core structure we have added substituted groups through which a chelating group, N2S2, was conjugated. We report herein a series of Tc-99m labeled stilbene derivative conjugated with a TcO[N2S2] core. The syntheses of stilbenes containing a N2S2 chelating ligand are achieved by a scheme shown. Lipophilic 99mTc stilbene complexes were successfully prepared and purified through HPLC. Preliminary results of in vitro labeling of brain sections from transgenic mice showed very promising plaque labeling. These 99mTc stilbene derivatives are warranted for further evaluations as potential imaging agents targeting amyloid plaques.

  6. Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

    Directory of Open Access Journals (Sweden)

    Xiaoping Zhan

    2015-06-01

    Full Text Available The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN. The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (p> 0.05. Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.

  7. The effect of Isosorbide Dinitrate on vascular endothelial growth factor production by human leukemic cell lines in vitro

    Directory of Open Access Journals (Sweden)

    Hajighasemi F

    2009-03-01

    Full Text Available "nBackground: Vascular endothelial growth factor (VEGF has mitogenic effect for endothelial cells and is an important mediator of tumor expansion, metastasis and angiogenesis in vivo. Isosorbide dinitrate, as a nitric oxide donor, has been widely used in treatment of many cardiovascular diseases such as congestive heart failure and acute coronary syndromes. Furthermore this drug was found to have inhibitory effect on angiogenesis, tumor growth and metastasis in vivo. In the present study we evaluated the isosorbide effect on the VEGF production using some human leukemic cell lines. "nMethods: Human leukemic MOLT-4, JURKAT and U937 cells were cultured in complete RPMI medium. The cells at the exponential growth phase were then incubated with different concentrations of Isosorbide (4´10-7 -4´10-4 M in the presence or absence of PMA (25ng/ml for 24 hours. The VEGF concentrations in the culture supernatants were measured by enzyme immunoassay kits (R&D systems according to the manufacturer's instructions. "nResults: The level of VEGF produced by the human leukemic cell lines which was treated with different concentrations of isosorbide, did not show any significant difference with untreated control cells. "nConclusions: The results of this study showed that isosorbide had no significant effect on VEGF production. Our findings suggest that anti-angiogenesis effect of isosorbide could be mediated through VEGF-independent mechanism(s. Further studies are warranted to determine definite isosorbide effect on VEGF and other angiogenic factors production in patients as well as animal models.

  8. Lessons from the Tc-99m shortage: implications of substituting Tl-201 for Tc-99m single-photon emission computed tomography.

    Science.gov (United States)

    Small, Gary R; Ruddy, Terrence D; Simion, Oana; Alam, Mohammed; Fuller, Lyanne; Chen, Li; Beanlands, Rob S; Chow, Benjamin J W

    2013-09-01

    In 2009, the Chalk River nuclear reactor closed for repairs that led to a critical shortage of technetium-99m (Tc-99m). Several centers used thallium-201 (Tl-201) as an alternative radiotracer for myocardial perfusion imaging. Because Tl-201 is considered by many as a suboptimal radiotracer, we sought to understand the impact of using Tl-201 (during the Tc-99m shortage) on downstream resource utilization. We performed a retrospective study at the Ottawa Heart Institute of 7402 patients (60% men; mean age, 62.6 ± 11.8 years), patients were referred for myocardial perfusion imaging between May 2008 and January 2011 (PRE_Tc-99m [2938 patients]), during (DURING_Tl-201 [2959 patients]), and after (POST_Tc-99m [1505 patients]) the Tc-99m shortage. Patients were followed for 6 months after their index myocardial perfusion imaging to determine subsequent rates of cardiac catheterization or noninvasive imaging. More downstream testing was seen in the Tl-201 cohort (639 [21.4%] patients) than the Tc-99m cohort (537 [12.1%] patients; PTl-201 cohort compared with the Tc-99m cohort ($90.97; 95% confidence interval, 83.42-98.90; PTl-201 (23.57 mSv; 95% confidence interval, 23.16-23.96) than in Tc-99m (12.92 mSv; 95% confidence interval, 12.55-13.40; PTl-201 during the Tc-99m shortage was associated with an increase in downstream testing, cost, and patient radiation exposure, but these findings may not be generalizable to other centers. Although Tl-201 provided a short-term solution to the unexpected Tc-99m shortage, long-term cost-effective solutions should be areas of future study.

  9. Comparison of efficacy of Tc-99m HIG and Tc-99m nanocolloid on sentinel lymph node mapping in patients with breast cancer.

    Science.gov (United States)

    Yalçin, Hulya; Gençoglu, Esra Arzu; Yagmurdur, Mahmut; Aras, Murat; Ozen, Aynur; Aktas, Ayse

    2010-10-01

    This study compared the effectiveness of Tc-99m human polyclonal immunoglobulin (HIG) and Tc-99m nanocolloid at detecting sentinel lymph nodes (SLNs) with lymphoscintigraphy and an intraoperative gamma-probe (IGP) in patients with early breast cancer. The study group consisted of 50 women; 25 patients each were given Tc-99m HIG or Tc-99m nanocolloid for lymphoscintigraphy. Then, intraoperative SLN localization with IGP was performed. The results of IGP, lymphoscintigraphy, blue dye injected just before surgery, and pathology were compared. In the Tc-99m HIG group, one patient had tumours in both breasts. In two patients, we could not detect SLNs with lymphoscintigraphy, although they were detected with IGP and blue dye. We found SLNs for all tumours with IGP. With the intraoperative blue dye, SLNs were identified for 25 tumours; for one tumour, no SLN was detected with blue dye. In the histopathological examination, 13 tumours showed metastasis in the SLN and in 11 of these 13, there were also metastases in the axilla. One patient had a skip metastasis. In the Tc-99m nanocolloid group, SLNs were identified in 24 patients with lymphoscintigraphy. IGP found SLNs in 24 patients. The blue dye detected SLNs in all patients. On histopathological examination, 10 patients had metastasis in the SLN and there were also metastases in the axilla in all of these patients. Tc-99m HIG can be used in SLN detection with preoperative lymphoscintigraphy and IGP in early-stage breast cancer patients.

  10. Evaluation of residual functional lung volume on Tc-99m DTPA aerosol ventilation and Tc-99m MAA perfusion scintigraphy in primary ciliary dyskinesia (Kartagener syndrome).

    Science.gov (United States)

    Chen, Yu-Wen; Chang, Chin-Chuan; Lai, Yung-Chuang; Lu, Chia-Ying; Dai, Zen-Kong

    2008-12-01

    Kartagener syndrome is diagnosed as sinusitis, bronchitis (bronchiectasis), and situs inversus by the clinical features. It is a subclass of primary ciliary dyskinesia (PCD) disease. A 12-year-old girl who had frequent upper and lower airway infections since birth, which was confirmed as Kartagener syndrome by HRCT imaging. We present the residual functional lung volume and mucociliary clearance findings seen on Tc-99m DTPA aerosol ventilation and Tc-99m MAA perfusion scintigraphy.

  11. In Vitro Evaluation of Tc-99m Radiopharmaceuticals for Gastric Emptying Studies

    Directory of Open Access Journals (Sweden)

    Türkan Ertay

    2014-02-01

    Full Text Available Objective: Gastrointestinal motility and functional motility disorders causing either delayed or accelerated gastric emptying (GE may result in similar symptoms including nausea, vomiting, early satiety, fullness, bloating, and abdominal discomfort or pain. Hence, it is important to evaluate patients for both rapid and delayed GE in the same test. The gold standard technique to measure GE is scintigraphy by radiolabeled test meals. The aim of this study was to test alternative Tc-99m agents to label eggs as the solid meal and compare to Tc-99m sulfur colloid (SC for gastric emptying studies. Methods: In search of alternative agents for gastric emptying studies, we mixed and fried eggs with four different particulate compounds (Tc-99m labeled SC, tin colloid, nanocolloid and MAA, as well as with free pertechnetate and Tc-99m DTPA. We then measured the stability of these compounds in simulated gastric juice. Results: Our experiments demonstrated that in addition to Tc-99m sulfur colloid;Tc-99m MAA, Tc-99m nanocolloid and Tc-99m tin colloid also appear to make stable complexes with eggs in acidic environment. Conclusion: Therefore, these agents may be used for gastric emptying studies which could be more practical in routine conditions.

  12. Sensitivity of [Tc-99m]methoxyisobutylisonitrile scan in patients with metastatic differentiated thyroid cancer

    NARCIS (Netherlands)

    Ronga, G.; Ventroni, G.; Montesano, T.; Filesi, M.; Ciancamerla, M.; Di Nicola, A. D.; Travascio, L.; Viestri, A. R.; Signore, A.

    2007-01-01

    Aim. The aim of the present study was to evaluate the diagnostic sensitivity of [Tc-99m]methoxyisobutylisonitrile ([Tc-99m]MIBI) in a large series of patients with metastatic differentiated thyroid carcinoma (DTC), as compared with I-131-whole body scan (WBS) and other diagnostic imaging techniques.

  13. Tc-99m-HMPAO brain scintigraphy. A comparative study with I-123-IMP

    Energy Technology Data Exchange (ETDEWEB)

    Nishimoto, Hitoshi; Yamamoto, Yoichi; Yoshida, Shoji; Akagi, Naoki; Ohara, Shuichi; Kamiike, Osamu; Maeda, Tomoho

    1989-04-01

    Sixteen single photon emission computed tomography (SPECT) studies with Tc-99m hexamethyl propylene amine oxime (Tc-99m HMPAO) were performed in patients with cerebral infarction (n=10), transient ischemic attack (n=2), or brain tumor (n=3). X-ray computed tomography (CT) scans and SPECT scans with N-isopropyl-p-(I-123)iodoamphetamine (I-123 IMP) were also obtained for comparison with findings of SPECT with Tc-99m HMPAO. Crossed cerebellar diaschisis (CCD) was detected in five patients (33%) on both early and delayed SPECT scans with Tc-99m HMPAO. In 8 patients, early scans with Tc-99m HMPAO tended to depict lesions more extensively when compared with CT. Early scanning with I-123 IMP was superior to that with Tc-99m HMPAO in detecting lesions. In detecting CCD, both methods were comparable to each other. In visualizing the basal ganglion, early scans with Tc-99m HMPAO were superior to scans with I-123 IMP. Tc-99m HMPAO has the advantages of short half-life period, small amounts of exposure doses, simple labeling, and prompt usage in emergency cases, such as cerebral infarction and cerebrovascular disorder. (Namekawa, K).

  14. Comparative study between the use of isosorbide dinitrate and captopril in hypertensive emergency treatment. Estudio comparativo entre el uso del dinitrato de isosorbide y el captopril en el traramiento de la urgencia hipertensiva.

    Directory of Open Access Journals (Sweden)

    Brandy Viera Valdés

    2005-05-01

    Full Text Available Fundament: Oral antihypertensive drugs are lacking in our environment at present in tog hypertensive urgencies, that is why new therapeutic alternatives are necessary to treat this medical problem. Objective: To assess the effect of Isosorbide Dinitrate in the treatment of hypertensive urgencies the system of urgencies. Method: a cuasi experimental study was designed with 60 patients with this diagnosis. The patients were divided into two groups. The patients of one group received treatment for the hypertensive crisis with Isosorbide Dinitrate 10 mg sub lingually and the others had their treatment with Captopril 25 mg p.o. Results: The response of the treatment with Isosorbide Dinitrate with similar to the treatment with Captopril. High Blood Pressure was controlled in 66,6 % with Isosorbide Dinitrate and in 73,3 % with Captopril, with few effects for both medications. Conclusions: Results were similar in this search with the use of Isosorbide Dinitrate and other antihypertensive drugs in the treatment of hypertensive urgencies . In the future, with the appearance of new evidencies Isosorbide Dinitrate could be used as an alternative in the treatment of hypertension at the urgency department when there is no possibility for applying any other medication.

    Fundamentación: En nuestro medio existen grandes dificultades con la disponibilidad de antihipertensivos orales para el tratamiento de la urgencia hipertensiva, por lo que es necesario la búsqueda de nuevas alternativas terapéuticas para este fin. Objetivo: Evaluar el efecto del dinitrato de isosorbide en el tratamiento de la urgencia hipertensiva en los sistema de urgencia. Métodos: Se diseñó un estudio cuasi experimental, donde fueron incluidos 60 pacientes con este diagnóstico, los cuales se

  15. Tc-99m sestamibi parathyroid gland scintigraphy: added value of Tc-99m pertechnetate thyroid imaging for increasing interpretation confidence and avoiding additional testing.

    Science.gov (United States)

    Powell, Daniel K; Nwoke, Franklin; Goldfarb, Richard C; Ongseng, Fukiat

    2013-01-01

    To evaluate the benefit of adding a pertechnetate parathyroid scan (dual-isotope imaging) in the interpretation of sestamibi dual-phase parathyroid scintigraphy. One hundred and sixteen dual Tc-99m sestamibi (MIBI) and Tc-99m pertechnetate subtraction parathyroid studies, performed between January 2000 and February 2006, were retrospectively reviewed. Dual-phase technetium sestamibi examinations were initially interpreted, with blinding to the technetium pertechnetate findings. Subsequently, technetium pertechnetate scan findings were added, and changes in interpretation were recorded. By adding Tc-99m pertechnetate imaging, the interpretation of 17 scans (17/116=14.6%) was substantially altered. This included 5 scans (4%) that changed from negative to positive and 9 scans (8%) that changed from equivocal to positive, excluding ectopic tissue and directing minimally invasive surgery, without the need for further imaging, such as ultrasound, in 12% of cases. One examination changed from positive to negative. In addition, 2 scans changed from equivocal to negative, necessitating further preoperative imaging for the evaluation of additional pathology such as thyroid nodules and lymph nodes and the consideration of hyperplasia. Among the remaining 99 patients, Tc-99m pertechnetate scans may also have contributed to the diagnosis in the 66 positive Tc-99m MIBI scans by increasing confidence in the interpretation and obviating additional imaging. Ten cases remained equivocal. By adding Tc-99m pertechnetate imaging, scan interpretation was changed in 14.6% of cases, and interpretation confidence was enhanced in all but 10 remaining equivocal cases. The addition of a dual-isotope subtraction also eliminated the need for additional testing, such as ultrasound, in 12% of our cases. Increased confidence in interpretation that comes with dual-isotope subtraction may come at the cost of slight lengthening of imaging time but likely simplifies preoperative localization and

  16. Bowel activity caused by free Tc-99m pertechnetate mimicking urine leaks during Tc-99m MAG{sub 3} renal scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Seok Tae; Kim, Min Woo; Sohn, Myung Hee [Chonbuk National University Medical School, Chonju (Korea, Republic of)

    2003-04-01

    A 43-year-old woman with diabetic nephropathy underwent a Tc-99m MAG3 renal scintigraphy for the evaluation of renal function. Posterior images at 60 minutes demonstrated a migration of radiotracer activity beyond the lower pole of the left kidney, which might be incorrectly interpreted as urine leaks. However, the increased activities were moving along the bowel lumens over time. Another ring-like radioactivity was also seen in the suprasplenic region, and increased with time. These radioactivities were in the gastric fundus and gastrointestinal tract and caused by free Tc-99m pertechnetate.

  17. A conveniently prepared Tc-99m resin for semisolid gastric emptying studies

    Energy Technology Data Exchange (ETDEWEB)

    Wirth, N.; Swanson, D.; Shapiro, B.; Nakajo, M.; Coffey, J.L.; Eckhauser, F.; Owyang, C.

    1983-06-01

    A polystyrene resin, suitable for semi-solid gastric emptying studies, was rapidly (less than 20 min) and conveniently prepared using commercially available reagents. Using the outlined procedure, Chelex-100 resin bound Tc-99m with greater than 98% labeling efficiency. The resulting Tc-99m Chelex-100 resin demonstrated excellent in vitro and in vivo stability. The clinical application of Tc-99m Chelex-100 resin, mixed with oatmeal, was tested in normal subjects and in various patient groups, including diabetic autonomic neuropathy, pyloric obstruction, postoperative dumping syndrome, and morbidly obese patients before and after gastroplasty.

  18. Conveniently prepared Tc-99m resin for semisolid gastric emptying studies

    Energy Technology Data Exchange (ETDEWEB)

    Wirth, N. (Univ. of Michigan, Ann Arbor); Shapiro, B.; Nakajo, M.; Coffey, J.L.; Eckhauser, F.; Owyang, C.

    1983-06-01

    A polystyrene resin, suitable for semi-solid gastric emptying studies, was rapidly (<20 min) and coveniently prepared using commercially available reagents. Using the outlined procedure, Chelex-100 resin bound Tc-99m with greater than 98% labeling efficiency. The resulting Tc-99m Chelex-100 resin demonstrated excellent in vitro and in vivo stability. The clinical application of Tc-99m Chelex-100 resin, mixed with oatmeal, was tested in normal subjects and in various patient groups, including diabetic autonomic neuropathy, pyloric obstruction, postoperative dumping syndrome, and morbidly obese patients before and after gastroplasty.

  19. The relationship between the percentage of lung shunting on Tc-99m macroaggregated albumin (Tc-99m MAA scan and the grade of hepatocellular carcinoma vascularity

    Directory of Open Access Journals (Sweden)

    Rania Refaat

    2014-06-01

    Conclusion: Tc-99m MAA scan is fundamental prior to Y-90 microsphere SIRT as it minimizes the risk of post-radioembolization complications, hence, enhancing the safety of Y-90 microsphere subsequent administration. Moreover, the percentage of lung shunting varies considerably among patients with HCC relying on the grade of tumor vascularity.

  20. [Use of a gamma probe for intraoperative localization of parathyroid adenomas with Tc-99m-tetrofosmin and Tc-99m-sestamibi].

    Science.gov (United States)

    Gallowitsch, H J; Fellinger, J; Kresnik, E; Mikosch, P; Pipam, W; Unterweger, O F; Lind, P

    1997-01-01

    Especially ectopic adenomas may be problematic in intraoperative localization despite preoperative imaging resulting in a longer operating time and more extensive surgical preparation. The aim of our study was to evaluate the possibility of intraoperative scintimetric detection of parathyroid adenomas with cationic, Tc-99m labelled tracers for its usefulness in ectopic adenomas. 12 women with biochemically confirmed hyperparathyroidism were included in our study. After injection of 370 MBq Tc-99m Tetrofosmin respectively Sestamibi, preoperative scintigraphy (double phase study and SPECT) was performed and T/NT ratios were evaluated for early, delayed and SPECT images. Surgery was performed using a hand-held gamma probe after preoperative injection of 555-925 MBq Tc-99m Tetrofosmin or Sestamibi. Count rates (cts/10 sec) were measured and used for calculating in situ- and ex situ-T/NT ratios. In 9 out of 12 patients, adenoma could be detected on static images. Three cases could only be detected with SPECT. 11 of 12 parathyroid adenomas could be confirmed intraoperatively. Intraoperative localization of parathyroid adenoma with Tc-99m-labelled cationic complexes and a gamma probe is possible and may be useful in case of ectopic adenoma by influencing surgical approach and operating time.

  1. Incidental detection of gastrointestinal stromal tumor by Tc-99m MDP bone scan.

    Science.gov (United States)

    Shepherd, Timothy M; Idakoji, Ibrahim A; Pampaloni, Miguel H

    2012-02-01

    This case demonstrates extraosseous 99m-technetium methylene diphosphonate (Tc-99m MDP) accumulation from a gastrointestinal stromal tumor. A 75-year-old woman underwent a temporal bone CT for conductive hearing loss that showed sclerosis in the right occipital condyle. Follow-up Tc-99m MDP bone scan for osseous metastases instead showed a mass-like extraosseous accumulation of Tc-99m MDP in the anterior left upper quadrant. Differential diagnoses included gastric cancer, lymphoma, metastatic melanoma, systemic hypercalcemia, or heterotopic mesenteric ossification. Contrast CT showed a well-circumscribed mass arising from the stomach, and subsequent pathology confirmed gastrointestinal stromal tumor. These tumors rarely can contain osteoclast-like giant cells and should be considered for extraosseous Tc-99m MDP accumulation.

  2. Evaluation of breast MIBI-Tc 99 m scintigraphy for the detection of breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Loriaux, C.; Baeyens, L.; Paternot, J.; Martin, P.; Verhas, M. [Hospital Universitaire Brugmann, Bruxelles (Belgium). Service de Medecine Nucleaire et Clinique de Senologie

    1997-12-31

    Full text. The aim of the work was to appreciate the contribution of MIBI-Tc 99 m scintigraphy for the detection of breast cancer and to situate this procedure in comparison with mammography 5 (X-ray M) and echography (E C). 21 patients presenting suspected lesion on clinical evaluation/or mammography were referred to the department for breast MIBI-Tc 99 m scintigraphy. 10 min after IV injection of MIBI-Tc 99 m 3 planar scan were realized with a present time of 10 min. The whole investigation including X-ray and surgical procedures were performed within 15 days. The pathologic findings were: 21 malignant lesion (18 canal cancers, 3 lobular cancers), 4 benign lesions (1 fibroadenoma, 2 granuloma, 1 fibrocystic disease). Lesions were bilateral in 3 cases and there was 1 bifocal lesion. 17 tumours were palpable and 8 not palpable, 10 lesion were <1 cm (40%), 9 were between 1,1 and 2,5 cm (36%) and 7 were >2,5 cm (24%). The overall sensitivity and specificity for MIBI-Tc 99 m were 67% and 75% respectively. For the group of palpable tumours, sensitivity of MIBI-Tc 99 m was 86%. In three cases, the X-ray M was difficult to interpret, the MIBI-Tc 99 m was true positive. In 3 false positive X-ray M procedures, the scintigraphy was true negative but, whatever the size of the tumor the best sensitivity was obtained with X-ray M (71%) and E C (70%) while for MIBI Tc-99 m, sensitivity was less (67%). MIBI-Tc 99 m appears to be a complementary tool in cases of difficulty of interpretation of mammography particularly in case of recurrence of the disease

  3. Tc-99m-EDDA-HYNIC-TOC somatostatin receptor scintigraphy in patients with carcinoids

    Directory of Open Access Journals (Sweden)

    Vlajković Marina

    2014-11-01

    Full Text Available The aim of this paper is to determine the influence of Ki-67 proliferation index on somatostatin receptor scintigraphy (SSRS with Tc-99m-EDDA-HYNIC-TOC (Tc-99m-Tektrotyd somatostatin analogue in patients with carcinoid tumors. Sixty-one patients (31 female, 30 male; age range: 33-76 years were examined: 13 patients highly suspected of having a carcinoid, and 48 patients who had undergone the surgical removal of the tumor. Whole body SSRS at 4 h postinjection, spot scintigrams and SPECT of the selected regions were obtained for all patients. Tc-99m-Tektrotyd scintigraphy was classified as true positive in 26 out of 30 and true negative in 24 out of 28 patients. The sensitivity of Tc-99mTc-Tektrotyd scintigraphy was found to be as high as 94.74% in the group of patients with low mitotic index Ki67 (20%. The likelihood of Tc-99m-Tektrotyd scan being positive when a carcinoid is present was found to be inversely proportional to the value of Ki67 proliferation index. The results showed that Tc-99m-Tektrotyd SSRS is a sensitive method for diagnosing and staging patients with well-differentiated carcinoid tumors. However, in poorly differentiated tumors with high Ki67 proliferation index, additional analyses are necessary for precise staging.

  4. Fraction of Tc99m-incorporations in the workplace activity in nuclear medicine; Anteil von Inkorporationen an der Arbeitsplatzaktivitaet fuer TC-99M in nuklearmedizinischen Einrichtungen

    Energy Technology Data Exchange (ETDEWEB)

    Schoenmuth, T. [VKTA Rossendorf (Germany); Alborzi, H. [LfULG Sachsen (Germany); Andeeff, M. [Uniklinikum Dresden (Germany); Lorenz, J. [SMUL Sachsen (Germany); Petzold, J. [Uniklinikum Leipzig (Germany)

    2009-07-01

    In the nuclear medicine, in particular in the area of the diagnostics, Tc-99m-Pharmaka are most often used. Besides, no regular monitoring occurred in praxi up to now. With use of the factors recommended, the requirement threshold (1 mSv committed dose in the calendar year) can be crossed in many areas. Within the scope of a study employees of different nuclear-medical facilities were examined in the period from March to July 2008. In the result of more than 200 measurements was founded out that a regular incorporation monitoring is not necessary for the examined employees. The estimated dose values (actual committed dose in the calendar year) was by the majority in an area below 0.1 mSv. If single evaluations of dose values are necessary an incorporation factor of 1E-07 is recommended by using connections on the basis of Tc-99m in the area of the nuclear-medical. (orig.)

  5. Tc-99m-tetrofosmin scintimammography: A prospective study in primary breast lesions

    Energy Technology Data Exchange (ETDEWEB)

    Lind, P. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Gallowitsch, H.J. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Kogler, D. [LKH Klagenfurt (Austria). Dept. of Radiology; Kresnik, E. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Mikosch, P. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Gomez, I. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology

    1996-12-01

    The purpose of our study was to evaluate prospectively the sensitivity, specificity, PPV and NPV of scintimammography with a new catonic complex Tc-99m-tetrofosmin. Methods: Fourtyeight patients in whom mammography and/or high resolution ultrasonography (10 MHz) revealed suspicious breast lesions were studied with Tc-99m-tetrofosmin scintimammography. In thirty four of them biopsy and/or surgery was performed for histological evaluation. After intravenous injection of 555 MBq Tc-99m-tetrofosmin dynamic images over three minutes planar images in anterior and lateral projections and SPECT imaging including 3-D-reconstruction (20 min. p.i.) were performed. Scintimammography was evaluated as negative, equivocal (+), probably (++) or definitely (+++) positive. Results: Scintimammography with Tc-99m-tetrofosmin was negative in 18 patients (17 t.n.; 1 f.n.) and positive in 16 patients (10 t.p., 6 f.p.). The false negative scintimammography was observed in a patient with infiltrating ductal carcinoma pT1, the false positive result in a patient with fibrocystic disease; all of the five fibroadenomas were also `false` positive. Sensitivity of Tc-99m-tetrofosmin scintimammography in this prospective study was 91%, specificity 74%, PPV 63% and NPV 94%. Scintimammographic results in patients with suspicious breast lesion show, that Tc-99m-tetrofosmin accumulates in breast cancer as well as in fibroadenoma. However the high NPV of 94% excludes breast cancer in suspicious mammographic lesions in a very high degree and therefore reduces the need of biopsy and/or surgery in most of these patients. Conclusion: Our first results show that scintimammography with Tc-99m-tetrofosmin might play a role as further diagnostic step before surgery for women in whom mammography and/or ultrasonography show suspicious lesions. [Deutsch] Ziel unserer prospektiven Studie war es, die Sensitivitaet, Spezifitaet sowie den positiven (PVW) und negativen Voraussagewert (NVW) der Mammoszintigraphie

  6. In vivo hepatic uptake inhibition study of Tc-99m-labeled hepatobiliary agents

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Meyoung Kon [National Institutes of Health, Bethesda (United States)

    1998-07-01

    We have previously reported that the hepatic uptake of Tc-99m-mercaptoacetyltriglycine (MAG3)-biocytin was not affected by coinjecting bilirubin in mice whereas the uptake of Tc-99m-diisopropyliminodiacetic acid (DISIDA) was inhibited (Kim et al. J Nucl Med, 38 : 50 p, 1997). The aim of this study was to investigate whether the hepatic uptake of Tc-99m-MAG3-biocytin or Tc-99m-DISIDA could be inhibited by biotin and biocytin. The Balb/c mice (female, 20g, n=5-8) were injected i.v. with the hepatobiliary agents alone (15-22 MBq/20-40 {mu}g) or together with inhibitors at two doses (14 and 28 mg/kg). For pharmacokinetic studies, images were acquired at 10-sec intervals for 20 min using a gamma camera equipped with a pin-hole collimator (d= 1 mm), starting immediately after intravenous injection. Pharmacokinetic parameters, peak liver/heart ratio (Rmax) and hepatic half clearance time (HCT), were calculated from liver and heart time-acitivity curves from regions-of-interest. Dynamic images showed rapid hepatic uptake inhibition was characterized by persistent high blood background. These qualitative scintigraphic findings were reflected in the pharmacokinetic parameters. Tc-99m-MAG3-biocytin without inhibitor coinjection showed Rmax of 9.3 and HCT of 383 sec. These parameters did not change significantly when bilirubin or biotin was coinjected, but did change significantly (P<0.05) for biocytin only at the higher dose: 52% decrease in HCT. In contrast, the parameters for Tc-99m-DISIDA (Rmax of 9.2 and HCT of 258 sec) were greatly affected (P<0.01) by biotin (79% decrease in Rman and 2-fold increase in HCT) even at 14 mg/kg concentration. We concluded that Tc-99m-MAG3-biocytin is less sensitive to inhibition by bilirubin, biotin, and biocytin than Tc-99m-DISIDA. Tc-99m-MAG3-biocytin appears to be a promising hepatobiliary imaging agent for hepatic function studies and may also be a useful tool to investigate the hepatic uptake mechanism of biotin derivatives in vivo.

  7. Tc-99m macro aggregated albumin scintigraphy – indications other than pulmonary embolism: A pictorial essay

    Science.gov (United States)

    Gandhi, Sunny J; Babu, Sanjay; Subramanyam, Padma; Shanmuga Sundaram, Palaniswamy

    2013-01-01

    Introduction: Tc-99m macro aggregated albumin (MAA) is synonymous for lung perfusion scintigraphy and is part of the study in the evaluation of pulmonary thromboembolism. We wanted to highlight the utilities of Tc-99m MAA other than pulmonary embolism as a pictorial assay. Materials and Methods: Patients referred for Tc-99m MAA scintigraphy under various indications were included in this pictorial essay. Commercially available TechneScan LyoMAA cold kit from Mallinckrodt Medical B.V., Holland was used. Acquisition protocols for different indications are described in this article. Different clinical indications (e.g., pulmonary artery stenosis, hepatopulmonary syndrome, FEV1 calculation in lung surgery planning, selective internal radiation therapy planning, venography for deep venous thrombosis, left to right cardiac shunts, etc.) where Tc-99m MAA scintigraphy was asked for; how it helped in different clinical scenarios and how it can be used clinically is explained with unique and interesting case examples and images. We also reviewed the literature to look for certain remote indications of MAA imaging for the sake of completion like – (shunt scintigraphy, peritoneopleural communication, etc.) Conclusion: Tc-99m MAA is a very useful radiopharmaceutical, which can be used for many other indications apart from the commonly used indication of lung perfusion scan in pulmonary embolism. It can provide useful clinical information in other indications, which we try to highlight in this article. PMID:24250023

  8. Tc-99m-MIBI Uptake in Active Pulmonary Tuberculosis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Ho; Park, Chan Hee; Hwang, Hee Sung; Bae, Moon Sun [Ajou University College of Medicine, Suwon (Korea, Republic of)

    1996-06-15

    Technetium-99m MIBI was developed as a myocardiac perfusion imagine agent and has been used effectively in the detection and post-therapeutic evaluation of various neoplasm such as thyroid, lung, bone and breast tumors. As an infrequent findings, Tc-99m MIBI agent has shown in non-neoplastic pulmonary conditions including fibroding alveolitis, pulmonary actinomycosis, active pulmonary sarcoidosis, pulmonary interstitial fibrosis in progressive systemic sclerosis and active osteomyelitis. In a recent report conducted by Cetin Oncel, Tc-99m MIBI imaging is an effective method in the detection and follow-up of pulmonary tuberculosis. We have also experienced Tc-99m-MIBI uptake in active pulmonary tuberculosis incidentally found in a patient with suspected proliferative villonodular synovitis of the left ankle.

  9. Tc-99m Dimercaptosuccinic Acid (DMSA) Renal Scintigraphy in Patients with Acute Pyelonephritis

    Science.gov (United States)

    Lee, Kang Wook; Bin, Ki Tae; Jeong, Min Soo; Shong, Min Ho; Shin, Young Tai; Ro, Heung Kyu

    1995-01-01

    Objectives Recently, several authors reported that Tc-99m DMSA renal scan frequently showed cortical defects of the involved kidneys even in the patients with acute pyelonephritis who did not show abnormal findings in the ultrasonography and intravenous pyelography IVP). Methods In order to evaluate the utilities of Tc-99m DMSA renal scan and the clinical meanig of cortical defects in the Tc-99m DMSA renal scan of the patients with acute pyelonephritis, ninety two patients with acute pyelonephritis, from March 1991 to February 1994 in Chungnam National University Hospital(CNUH), were included in this study. Patients were subdivided as Group A:Patients showing normal Tc-99m DMSA renal scan(n=42) and Group B:Patients with definit cortical defects on the Tc-99m DMSA renal scan(n=50). We compared clinical characteristics such as age and sex, recurrency, duration of fever, bacterial culture study, incidence of renal insufficiency and the results of renal ultrasonography and intravenous pyelography between the two groups. Results Fifty four percents of 92 patients with acute pyelonephritis showed a significantly longer febrile period after admission, higher positive rates on the urine and blood culture studies and higher incidence of renal insufficiency than those of the Group A patients. Sixty nine percents of Group B patients showed normal results in ultrasonography or IVP study. Conclusions Tc-99m DMSA renal scan was a more sensitive imaging test than ultrasonography in kidneys and IVP to detect pyelonephritis lesions and may be useful to predict the patient group with a severe disease course. These patients may need more careful management and further studies to evaluate the possibility of complications. PMID:7626556

  10. Homogeneous SLOWPOKE reactors for Mo-99/Tc-99m production in North America

    Energy Technology Data Exchange (ETDEWEB)

    Hilborn, J.W., E-mail: hilbovanw@sympatico.ca [Deep River, Ontario (Canada); Bonin, H.W. [Royal Military College of Canada, Kingston, Ontario (Canada)

    2014-07-01

    The 15 month shutdown of NRU in 2009 - 2010 caused an overall isotope shortage of approximately 30%; and in North America, the annual Tc-99m demand decreased from an estimated 20 million unit doses to about 15 million unit doses. Mo-99/Tc-99m is produced from HEU targets, irradiated in NRU for 11 days, and after chemical removal of uranium it is shipped to Nordion in Kanata, Ontario. Nordion further purifies the material and sends it to Lantheus Medical Imaging in the USA for manufacture of Mo-99 generators, which are then distributed to hundreds of hospital radiopharmacies throughout North America. One other American company, Covidien, manufactures and distributes Mo-99 generators like Lantheus, but they import bulk Mo-99 from Europe or South Africa. At the hospitals, Tc-99m is chemically extracted daily from the Mo-99 generators and loaded into syringes for immediate clinical use. Fortuitously, the 66 hour half-life of Mo-99 allows the replenishment of Tc-99m in the generator over a growth period of about 20 hours; and a generator can be 'milked' daily for up to two weeks. A more efficient model is the direct production and distribution of Tc-99m unit doses to regional hospitals from 10 'industrial' radiopharmacies located at existing licensed reactor sites in North America. A 20 kW homogeneous SLOWPOKE reactor at each site would deliver 15 litres of irradiated uranyl sulphate fuel solution daily to industrial-scale hot cells for extraction of Mo-99, which would be incorporated in large Mo-99/Tc-99m generators for extraction of Tc-99m five days a week; and the Low Enriched Uranium (LEU) would be recycled. Each automated hot-cell facility would be designed to load up to 7,000 Tc-99m syringes daily, for courier delivery to all of the Nuclear Medicine hospitals within a 3 hour average range by road transport. Typically, the delivered doses would be in the range 10 to 30 mCi. Assuming an average unit dose of 25 mCi at the hospital and 5 x 52

  11. Extrarenal abnormalities in Tc-99m-DTPA renal blood flow studies

    Energy Technology Data Exchange (ETDEWEB)

    Shih, W.J.; Domstad, P.A.; DeLand, F.H.

    1985-01-01

    The authors observed extrarenal abnormalities during renal flow scintigraphy and retrospectively reviewed 90 patient studies to determine the types and frequencies of such abnormal findings. For each routine Tc-99m-DTPA renal flow study, they obtained nine 2-second sequential images, which included the heart, abdominal aorta, spleen and kidneys. Eighty abnormalities, observed in 62 patients, were divided into three categories: aortic, 37 cases; splenic, 40 cases; and miscellaneous, 3 cases. Other correlative studies including Tc-99m sulfur colloid-spleen scintigraphy, ultrasonography (US), CT, aortography, and surgical and/or autopsy findings were available for corroboration in 56 of 80 lesions.

  12. Detection of acute cerebral ischaemia with Tc-99m apcitide scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Tepmongkol, S. [Nuclear Medicine Division, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok 10330 (Thailand)

    2002-10-01

    The established indication for Tc99m apcitide scintigraphy is for detecting deep venous thrombosis. However, due to its mechanism of binding to GP IIb/IIIa receptors on activated platelets, it can be used to image acute cerebral thrombosis. I report a patient with an acute ischaemic stroke, with right leg swelling, referred for Tc99m apcitide scintigraphy to show of deep venous thrombosis. There was no abnormal uptake in the legs but there was in the left parieto-occipital region. This correlated with the clinical and CT data, indicating an acute ischaemic stroke in this area. (orig.)

  13. Lung and renal uptake of techneticum Tc 99m sulphur colloid related to disseminated intravascular coagulation

    Energy Technology Data Exchange (ETDEWEB)

    Jelle Teertstra, H.; Verdegaal, W.P.; Ras, G.J.

    1985-01-01

    In addition to a recently published case study, we present another three cases in which we observed both lung and renal uptake of technetium Tc 99m sulphur colloid which was related to a period of disseminated intravascular coagulation. Being familiar with this relationship may influence the diagnosis and course of the illness in certain patients.

  14. Tc-99m pyrophosphate scanning after ischemic exercise in McArdle's disease

    Energy Technology Data Exchange (ETDEWEB)

    Uno, Hideaki; Kawano, Keizo; Yukawa, Susumu; Nomoto, Hiroshi (Wakayama Medical Coll. (Japan))

    1982-03-01

    In order to clarify the mechanism of muscle contracture induced by ischemic exercise in a patient with McArdle's disease, bone scanning with Tc-99m pyrophosphate was performed. The clinical diagnosis was established in the patient based on the biochemical examinations of skeletal muscle biopsy. Ischemic exercise was done initially on the left forearm and then 20 hours later on the right forearm. Two hours later, 15 mCi of Tc-99m pyrophosphate was infused through the left antecubital vein. Exactly 4 hours later, a conventional bone scanning was carried out. In the patient with McArdle's disease, muscle contracture developed in both forearms during the ischemic exercise. Conventional bone scanning showed increased Tc-99m pyrophosphate labeling of the right forearm muscles at 2 hours after ischemic exercise. However, increased labeling of the left forearm muscles was not found at 22 hours after ischemic exercise. In the control, no muscle contracture developed during ischemic exercise and bone scan showed no increase in Tc-99m pyrophosphate labeling in the antebrachial region. These findings suggest that the basis of muscle contracture appears to be an increased concentration of Ca in muscle cells due to a failure of sarcoplasmic reticulum to reaccumulate Ca at ischemic exercise.

  15. Tc-99m erythromycin lactobionate inhalation scintigraphy in parenchymal lung diseases

    Energy Technology Data Exchange (ETDEWEB)

    Durak, Hatice E-mail: hdurak@kordon.deu.edu.tr; Aktogu, Serir; Degirmenci, Berna; Sayit, Elvan; Ertay, Tuerkan; Dereli, Sevket

    1999-08-01

    We have investigated Technetium 99m erythromycin lactobionate (Tc 99m EL) clearance from the lungs after inhalation, in the presence of an alveolitis. Eighteen patients (6 sarcoidosis, 7 idiopathic fibrosis, and 5 miliary tuberculosis) were imaged after the patients inhaled 1,110 MBq of Tc 99m EL. Clearance half time for the first 45 min, for 24 h, and retention at 24 h correlated with percentage of lymphocytes in bronchoalveolar lavage fluid (BAL) (r=.729, r=.883, and r=.826, respectively). There was a positive correlation between peripheral penetration (PP) and forced expiratory volume in 1 s (FEV{sub 1}) (r=.806) and forced vital capacity (FVC) (r=.781). Retention was more marked in sarcoidosis compared with tuberculosis (0.025Tc 99m EL may be related to number of BAL cells or presence of a lymphocytic alveolitis. Long residency time of Tc 99m EL in the lungs implies that erythromycin can also be administered by inhalation for therapeutic purposes.

  16. Incidental detection of a bleeding gastrointestinal stromal tumor on Tc-99m red blood cell scintigraphy.

    Science.gov (United States)

    Santhosh, Sampath; Bhattacharya, Anish; Gupta, Vikas; Singh, Rajinder; Radotra, Bishan Dass; Mittal, Bhagwant Rai

    2012-10-01

    The role of 99m-technetium labeled red blood cell (RBC) scintigraphy in acute gastro-intestinal bleed is well-established. The authors report a case of a bleeding gastrointestinal stromal tumor (GIST) incidentally discovered on Tc-99m RBC scintigraphy.

  17. Investigation of Tc-99m-labelling of recombinant human interleukin-2 via hydrazinonicotinamide

    NARCIS (Netherlands)

    Karczmarczyk, Urszula; Garnuszek, Piot; Maurin, Michal; Di Gialleonardo, Valentina; Galli, Filippo; Signore, Alberto; Mikolajczak, Renata

    2010-01-01

    Introduction: Interleukin-2 (IL-2) when radiolabelled with Tc-99m has been proved useful in imaging the side of lymphocytic infiltration in patients with autoimmune disorders and plays a significant role as a T-cell imaging agent. However, the labelling procedures used so far appeared to be rather c

  18. Tc-99m HM-PAO labelling of leukocytes for detection of inflammatory bowel disease

    Energy Technology Data Exchange (ETDEWEB)

    Schuemichen, C.; Schoelmerich, J.

    1986-10-01

    Labelling of purified leukocytes with the brain imaging agent Tc-99m HM-PAO proved to be a reliable method, yielding a 45% labelling efficiency in phosphate buffer and leaving more than 85% of the leukocytes viable. In fifteen patients with M. Crohn, a positive finding was shown in all cases on the six hour image.

  19. Cerebral infarction mimicking brain tumor on Tc-99m tetrofosmin brain SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Soon [College of Medicine, Dongguk Univ., Gyeongju (Korea, Republic of); Zeon, Seok Kil; Won, Kyoung Sook [School of Medicine, Keimyung Univ., Daegu (Korea, Republic of)

    2004-06-01

    A 43-year-old man was presented with persistent headache for two weeks. T2 weighted MR imaging showed high signal intensity with surrounding edema in the left frontal lobe. These findings were considered with intracranial tumor such as glioma or metastasis. Tc-99m tetrofosmin SPECT showed focal radiotracer accumulation in the left frontal lobe. The operative specimen contained cerebral infarction with organizing leptomeningeal hematoma by pathologist. Another 73-year-old man was hospitalized for chronic headache. Initial CT showed ill-defined hypodensity with mass effect in the right parietal lobe. Tc-99m tetrofosmin SPECT showed focal radiotracer uptake in the right parietal lobe. These findings were considered with low-grade glioma or infarction. Follow-up CT after 5 months showed slightly decreased in size of low density in the right parietal lobe, and cerebral infarction is more likely than others. Tc-99m tetrofosmin has been proposed as a cardiotracer of myocardial perfusion imaging and an oncotropic radiotracer. Tc-99 tetrofosmin SPECT image provides a better attractive alternative agent than TI-201 as a tumor-imaging agent, with characteristics such as high-energy flux, short half-life, favorable biodistribution, dosimetry and lower background radioactivity. We have keep in mind on the analysis of Tc-99m tetrofosmin imaging when cerebral infarction is being differentiated from brain tumor.

  20. Lesion localization in patients with hyperparathyroidism using double-phase Tc-99m MIBI parathyroid scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jung Woo; Ryu, Jin Sook; Kim, Jae Seung; Moon, Dae Hyuk; Hong, Seung Mo; Gong, Gyung Yub; Hong, Suk Joon; Lee, Hee Kyung [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    1999-02-01

    This study was performed to evaluate the diagnostic usefulness of double-phase Tc-99m MIBI parathyroid scintigraphy with single photon emission computed tomography (SPECT) in patients with hyperparathyroidism. We also evaluated the relationship between Tc-99m MIBI uptake and oxyphil cell contents in parathyroid glands. The subjects were 28 parathyroid glands of 10 patients who underwent Tc-99m MIBI parathyroid scintigraphy and parathyroidectomy for clinically suspected hyperparathyroidism. Early and delayed pinhole images were obtained at 15 minutes and 2 hours after injection of Tc-99m MIBI, and SPECT images were followed. The weight and oxyphil cell contents of parathyroid tissue were obtained from pathologic specimen, and the scintigraphic findings were compared with histopathology. In surgical histopathology, 6 parathyroid adenomas and 9 parathyroid hyperplasias were confirmed. The sensitivity, specificity, and positive predictive value of early and delayed images were 46.7% (7/15), 76.9% (10/13), 70% (7/10) and 66.7% (10/15), 92.3% (12/13), 90.9% (10/11), respectively. SPECT image detected an additional small hyperplasia. The sensitivity, specificity, and positive predictive value of combined interpretation of early and delayed images with SPECT were 73.3% (11/15), 100% (13/13), 100% (11/11). The sensitivity was 100% (6/6) for adenoma, whereas that was 55.5% (5/9) for hyperplasia. Both adenomas and hyperplasias showed significantly increased oxyphil cell contents compared with normal parathyroid glands (p<0.0001), but the oxyphil cell content and weight were not significantly different between adenomas and hyperplasias. Double-phase Tc-99m MIBI parathyroid scintigraphy with SPECT is useful for lesion localization in patients with hyperparathyroidism. Although both adenoma and hyperplasia have increased oxyphil cell content, the sensitivity is high in adenoma, but low in hyperplasia.

  1. [Chronic aortic and mitral valve regurgitation. Effects of isosorbide dinitrate on systolic function and passive elastic properties of the left ventricle (author's transl)].

    Science.gov (United States)

    Herreman, F; Cosma, H; Degeorges, M

    1982-06-10

    A haemodynamic and cineangiographic study was conducted in 20 patients with chronic aortic regurgitation alone or associated with mitral regurgitation before and during i.v. administration of isosorbide dinitrate 5 mg/hour. Freedom from coronary disease had been ascertained. The heart rate and aortic pressure (initially normal), cardiac index (initially low), pulmonary pressures and pulmonary and systemic resistances (slightly raised initially) remained unchanged. On the other hand, the left ventricular (LV) filling pressure, distinctly raised before treatment, was reduced by 17% (p less than 0.05). There was also a 10% reduction in LV end-diastolic volume (from 204 +/- 60- cm3.m2 to 184 +/- 56 cm3,m2; p less than 0.001) and a 14% reduction in LV end-systolic volume (from 104 +/- 39 cm3.m2 to 89 +/- 40 cm3.m3; p less than 0.001). LV geometry, stroke volume and regurgitation volume were unmodified. There was a significant improvement in ventricular function indices, globally reduced before treatment: + 8% for the fiber shortening amplitude (p less than 0.025), + 6% for the ejection fraction (p fiber shortening (p less than 0.01), and + 15% for the ESP: ESV ratio (p less than 0.05). The passive elasticity indices, all increased before treatment, also improved. It is concluded that isosorbide dinitrate improves LV systolic and diastolic functions in patients with chronic valve disease.

  2. Tc-99m-labeled red blood cells for the measurement of red cell mass in newborn infants: concise communication

    Energy Technology Data Exchange (ETDEWEB)

    Linderkamp, O.; Betke, K.; Fendel, H.; Klemm, J.; Lorenzen, K.; Riegel, K.P.

    1980-07-01

    In vitro and in vivo investigations were performed to examine the binding of Tc-99m to neonatal red blood cells (RBC). Labeling efficiency was about 90%, and unbound Tc-99m less than 3% after one washing, in premature and full-term newborns and in children. Thus presence of high percentages of fetal hemoglobin (Hb F) did not influence the labeling of RBCs with Tc-99m. RBCs of 11 newborns were hemolysed and the distribution of Tc-99m on RBC components was analyzed. Although Hb F percentage averaged (60.0 +- 8.10)% (s.d.), only (11.9 +- 3.7)% of Tc-99m was bound by Hb F, whereas (45.0 +- 6.1)% was associated with Hb A. RBC membranes bound (13.7 +- 4.3)% and (29.3 +- 4.0)% were found unbound in hemolysates. These results indicate that Tc-99m preferentially binds to beta chains. In vivo equilibration of Tc-99m RBCs and of albumin labeled with Evans blue was investigated in five newborn infants. Tc-99m RBCs were stable in each case during the first hour after injection. Elution of Tc-99m from RBCs was (3.4 +- 1.5)% per h. Body-to-venous hematocrit ratio averaged 0.86 +- 0.03.

  3. Radiation protect during the ventilation scintigraphy of Tc99m DTPA radioaerosol in pediatric application

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yu-Wen; Dai, Zen-Kong; Huang, Ying-Fong; Jong, Shiang-Bing [Chou-Hon Memorial Hospital, Kaohsiung Medical Univ., Kaohsiung, Taiwan (China)

    2000-05-01

    Lung ventilation-perfusion scintigraphy is of great value for the management of patients with both primary lung disease and heart disease, by proving patho- physiological information of importance for the diagnosis, follow-up and functional evaluation of the patients. Krypton 81m radioactive gas is preferable for pediatric application due to its short half-life. However, the rubidium-krypton 81m generator is not popular in hospital of our country. Tc99m DTPA radioaerosol ventilation scintigraphy has its unique convenient for clinical application. But, the most disadvantage of clinical application of Tc99m DTPA radioaerosol is contamination of environment when the poor-cooperative patient can't breathe by mouth. For this reason, we design the certain procedure to reduce the radioaerosol contamination. During May to Aug., 1999, we collect 36 pediatric patients (male to female ratio 2:1, age from 6 months to 20 years old) with clinical history of lung or heart disease, including congenital heart disease, asthma and so on. Before the cases receive 10 to 15 mCi Tc99m DTPA radioaerosol ventilation scan, all of them were trained with breath training. And during the ventilation scintigraphy, the special mouth mask is designed to prevent the radioaerosol leakage into atmosphere. Then Geiger-Muller survey meter was arranged to detect the environmental contamination of radioaerosol in the mask, one and two metes away from the mask every 10 minutes during ventilation scintigraphy procedure and 1 hour after finishing image. Two nuclear medicine physicians evaluated imaging quality of ventilation scintigraphy. Results: Among thirty-six pediatric patients with prior breath training, thirty-two cases are successful to proceed the Tc99m DTPA ventilation scintigraphy. The other four cases that were under three-year-old fail to receive ventilation scintigraphy. There is limited detectable radioactivity in the mouth mask at early 10 minute by Geiger-Muller counter. No significant

  4. Tc-99m-bicisate (ECD)-brain-SPECT in rapidly progressive dementia; Hirn-SPECT mit Tc-99m-Bicisat (ECD) bei rasch progredientem dementiellen Syndrom

    Energy Technology Data Exchange (ETDEWEB)

    Marienhagen, J.; Eilles, C. [Regensburg Univ. (Germany). Abt. fuer Nuklearmedizin; Weingaertner, U.; Blaha, L. [Bezirkskrankenhaus Mainkofen (Germany). Psychiatrische Klinik; Zerr, I.; Poser, S. [Goettingen Univ. (Germany). Klinik und Poliklinik fuer Neurologie

    1999-07-01

    We present a 61-year-old male patient with progressive dementia. A brain SPECT with Tc-99m-bicisate was performed for confirmation of clinically suspected Alzheimer-dementia. At the time of the SPECT-investigation marked apraxia and aphasia besides severe dementia were present. Electrophysiological as well as anatomical neuroimaging findings showed non-diagnostic alterations. SPECT revealed distinct perfusion defects, which made Alzheimer Dementia unlikely. The further course of the patient was determined by rapidly progressive deterioration with development of akinetic mutism. Thereafter, increased levels of neuron-specific enolase as well as 14-3-3 proteins were found in the cerebro-spinal fluid (CSF). The patient finally died with signs of cerebral decortication. Due to the clinical course and the CSF-findings the patient's final diagnosis was Creutzfeld-Jakob-disease, nevertheless no autopsy was performed. The presented case report underscores the clinical utility of perfusion brain SPECT in the differential diagnosis of dementias. (orig.) [German] Wir berichten ueber einen 61jaehrigen Patienten mit progredientem dementiellen Syndrom, der unter der Verdachtsdiagnose einer Demenz vom Alzheimer-Typ (DAT) zur Hirn-SPECT-Untersuchung mit TC-99m-Bicisat (ECD) vorgestellt wurde. Zum Untersuchungszeitpunkt bestanden neben dem Vollbild einer Demenz eine ausgepraegte Apraxie und Aphasie bei unspezifischen Veraenderungen im EEG sowie der neuroradiologischen Bildgebung. In der Hirn-SPECT-Untersuchung fanden sich fuer eine DAT untypische ausgedehnte, vorwiegend rechtshemisphaerische Perfusionsstoerungen. Im weiteren Verlauf rasche Progredienz des Krankheitsbildes mit Entwicklung eines akinetischen Mutismus sowie Nachweis erhoehter Werte der neuronspezifischen Enolase und des 14-3-3-Proteins im Liquor. Der Patient verstarb schliesslich unter dem Bild einer Decortication. Aufgrund des klinischen Verlaufs sowie der Liquorbefunde wurde, da eine autoptische Befundsicherung

  5. Lung mass appearing as a dilated left ventricle on Tc-99m tetrofosmin myocardial perfusion scintigraphy.

    Science.gov (United States)

    Gnanasegaran, Gopinath; Williams, Robert; Mclean, Emma; O' Connell, Rachel; Nunan, Thomas O; O'Doherty, Michael J

    2009-09-01

    Tc-99m tetrofosmin is a common tracer used in myocardial perfusion scintigraphy. Several benign and malignant tumors also take up tetrofosmin. We present a case of a 60-year-old woman with a history of a left lung mass awaiting resection. The patient was referred for a myocardial perfusion scan for preoperative risk assessment. The myocardial perfusion scan revealed a large cavitated lesion mimicking a dilated left ventricle and the CT scan revealed a large mass in the left lung with central necrosis displacing the heart and mediastinum. The patient underwent thoracotomy with resection of the mass and the histology confirmed atypical carcinoid. This case highlights noncardiac uptake of Tc-99m tetrofosmin in an atypical carcinoid.

  6. Synovial visualization during Tc-99m MDP bone scanning in septic arthritis of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Yon, J.W. Jr.; Spicer, K.M.; Gordon, L.

    1983-06-01

    During Tc-99m medronate (MDP) bone scintigraphy, visualization of the synovium during blood flow and blood pool phases was present in a patient with septic arthritis of the left knee. Inflammation with hyperemia of the synovium was the cause for radionuclide localization, which was enhanced by the large photon-deficient effusion distending the suprapatellar bursa. The synovium was not seen on delayed images after redistribution of the radionuclide from blood pool to bone phase.

  7. Comparison of Tc-99m MDP and Sm-153 EDTMP bone scan

    OpenAIRE

    Lele, Ramchandra D

    2011-01-01

    While fluoro-deoxy-glucose (FDG) has emerged as an important radiotracer for imaging tumors, myocardial viability and infection, the role of other glucose analogues should also be explored. Tc-99m Glucoheptonate (GHA) has been used for imaging brain tumors and lung tumors. The uptake mechanism may be linked to GLUT-1 (Glucose transporter) and GLUT-4 expression similar to FDG. GHA is easily available and cheap. With the availability of single photon emission computed tomography/computed tomogr...

  8. Diagnosis of clinically unsuspected gallbladder perforation in an obese patient, by Tc-99m IDA cholescintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Mesgarzadeh, M.; Haines, J.E.; Bobba, V.R.; Von Dollen, L.E.; Jarboe, G.; Krishnamurthy, G.T.

    1983-11-01

    A male Pickwickian syndrome patient was admitted to the hospital with sudden onset of abdominal pain. Physical examination was equivocal. Due to patient's ileus and morbid obesity (weight 450 lb), neither TCT scan nor ultrasound was possible. A Tc-99m PIPIDA hepatobiliary imaging study revealed intraperitoneal leakage of radioactive bile with collection of the activity in both abdominal gutters, indicating gallbladder rupture. Prompt surgery confirmed the diagnosis.

  9. Multifocal peritoneal splenosis in Tc-99m-labeled heat-denatured red blood cell scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Min Ki; Hwang, Kyung Hoon; Choe, Won Sick [Gachon University Gil Medical Center, Incheon (Korea, Republic of)

    2006-06-15

    A 44-year-old man with a past medical history of splenectomy came to hospital because of epigastric pain abdominopelvic computed tomography(CT) showed a soft tissue mass and multifocal variable-sized nodules as well as finding suggestive of cholecystitis. Subsequently, he underwent Tc-99m-labeled heat- denatured red blood cell(RBC) scintigraphy to evaluate the mass and nodules. The scintigraphy confirmed multifocal peritoneal splenosis in the abdominopelvic cavity.

  10. Cost comparison analysis: pentaerythrithyl tetranitrate (PETN) and isosorbide dinitrate (ISDN) prescribed to diabetic patients in primary care practices in Germany.

    Science.gov (United States)

    Icks, A; Haastert, B; Rathmann, W; Schröder-Bernhardi, D; Giani, G

    2007-09-01

    Both pentaerythrithyltetranitrate (Pentalong, PETN) and isosorbide dinitrate (ISDN) are commonly used in the therapy of ischemic heart disease (IHD). However, little is known about the therapeutic patterns in diabetic patients and no comparative data are available regarding the prescription costs of these two substances. Thus, the aim of this investigation was to compare the costs for PETN and ISDN therapy in diabetic patients in primary care. All continuously treated patients aged > or = 40 years with diabetes (anti-diabetic agents) and IHD or angina pectoris (ICD codes) and newly started on PETN or ISDN therapy (index date) in the period 2000-2005 were selected from a database containing data from 400 practices throughout Germany (Disease Analyzer, IMS Health). Prescriptions costs for PETN and ISDN, as well as costs for cardiovascular comedication, were determined for the period 183 days before and after the index date, and that changes in costs after the index date were calculated. Differences in costs between the two groups were evaluated using multivariate regression, adjusting for age, sex and comorbidity. Patients in Eastern (n = 137, age 71 +/- 10 years, 55% male) and Western Germany (n = 212, age 73 +/- 9 years, 50% male) were analyzed separately since there is a longer history of PETN use in Eastern Germany. Significantly more patients were treated with PETN in Eastern Germany (61 vs. 11%, p PETN and ISDN differed with respect to sex and comorbidity. PETN therapy was more expensive than ISDN therapy in both German regions (adjusted cost differences were 10 and 17 Euro). However, when comedication was taken into account, a smaller cost increase after the index date was observed in the PETN group than in the ISDN group (non-significant cost savings of 43 and 52 Euro after adjustment for Western and Eastern Germany, respectively). PETN therapy tends to produce a saving in costs compared to ISDN therapy in diabetic patients when costs for comedication are

  11. Evaluation of splenic autotransplant using Tc-99m-damaged erythrocytes

    Energy Technology Data Exchange (ETDEWEB)

    Mansi, L.; Salvatore, M.; Ariemma, G.; Tricarico, A.; Sicoli, F.; Calise, F.

    1985-05-01

    In order to avoid functional damage due to splenectomy, autologous heterotopic transplant of splenic slices was performed in 24 acutely traumatized patients. These patients were studied at different times ( 10 days to 1 year ) following autotransplant, after i.v. injection of 110 MBq (3 mCi) of Tc-99m labeled erythrocytes (damaged by heating at 49.5/sup 0/C for 15 minutes). Whole body scans were obtained 1 hour after the injection, using a computerized gamma camera. Haemocatheretic function was demonstrated in all patients, at the level of heterotopic tissue, starting one month after surgery, with an increase in tissue volumes and radiotracer uptake in follow up studies. Activity was also seen in liver and, mainly 10 days after transplant, in bone marrow. No significant uptake was seen at thyroid level. No further information was obtained analyzing the angiographic phase and/or 24 hours delayed scans. In 5 patients Tc-99m-erithrocytes proved to be better than Tc-99m-colloids for splenic autotransplant imaging, mainly in early examinations. The authors conclude that radioisotopic studies can give both a functional evaluation and a morphologic demonstration of splenic transplanted tissue, in comparison with the purely morphological analysis allowed for by CT and US.

  12. Tc-99m ciprofloxacin imaging in diagnosis of chronic bacterial prostatitis

    Institute of Scientific and Technical Information of China (English)

    Ji-KanRyu; Seong-MinLee; Do-WhanSeong; Jun-KyuSuh; SungeunKim; WonsickChoe; YeonsookMoon; Soo-HwanPai

    2003-01-01

    Aim:To investigate the value of Tc-99m ciprofloxacin imaging in the differential diagnosis of chronic bacterial prostatitis. Methods: The study included 4 normal subjects as the negative controls, 2 patients with acute prostatitis or cystourethritis as the positive controls and 59 patients diagnosed as chronic bacterial prostatitis or chronic pelvic pain syndrome by traditional laboratory tests. In every subject, the single photon emission computer-ized tomography images were obtained 3 h after intravenous injection of Tc-99m Ciprofloxacin. The results of the imaging were compared with those of laboratory tests. Results: On the images, negative uptake was observed in all normal subjects, while strong hot uptake, in the whole prostate of acute prostatitis patients and in the whole urethra of acute cystourethritis patients. In 13 (68 %) of 19 patients categorized as chronic bacterial prostatitis by standard laboratory tests, hot uptake with less intensity than that of acute prostatitis was observed in the prostate area around the prostatic urethra. Negative uptake in the prostate was observed in 6 of 19 patients (32 %) categorized as chronic bacterial prostatitis. Interestingly, hot uptake in the prostate was exhibited in 28 (70 %) of the 40 patients categorized as chronic pelvic pain syndrome. Conclusion: Tc-99m ciprofloxacin imaging is helpful in the differential diagnosis of prostatitis syndrome. (Asian J Androl 2003 Sep; 5:179-183 )

  13. Development of Tyrosine-Based Radiotracer Tc99m-N4-Tyrosine for Breast Cancer Imaging

    Directory of Open Access Journals (Sweden)

    Fan-Lin Kong

    2012-01-01

    Full Text Available The purpose of this study was to develop an efficient way to synthesize Tc99m-O-[3-(1,4,8,11-tetraazabicyclohexadecane-propyl]-tyrosine (Tc99m-N4-Tyrosine, a novel amino acid-based radiotracer, and evaluate its potential in breast cancer gamma imaging. Precursor N4-Tyrosine was synthesized using a 5-step procedure, and its total synthesis yield was 38%. It was successfully labeled with Tc99m with high radiochemical purity (>95%. Cellular uptake of Tc99m-N4-Tyrosine was much higher than that of Tc99m-N4 and the clinical gold standard 18F-2-deoxy-2-fluoro-glucose (18F-FDG in rat breast tumor cells in vitro. Tissue uptake and dosimetry estimation in normal rats revealed that Tc99m-N4-Tyrosine could be safely administered to humans. Evaluation in breast tumor-bearing rats showed that although Tc99m-N4-Tyrosine appeared to be inferior to 18F-FDG in distinguishing breast tumor tissue from chemical-induced inflammatory tissue, it had high tumor-to-muscle uptake ratios and could detect breast tumors clearly by planar scintigraphic imaging. Tc99m-N4-Tyrosine could thus be a useful radiotracer for use in breast tumor diagnostic imaging.

  14. Left-ventricular dyssynchrony evaluated by Tl-201 gated SPECT myocardial perfusion imaging: a comparison with Tc-99m sestamibi.

    Science.gov (United States)

    Chen, Chien-Cheng; Huang, Wen-Sheng; Hung, Guang-Uei; Chen, Wan-Chen; Kao, Chia-Hung; Chen, Ji

    2013-03-01

    Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has been validated as a reliable tool to assess left-ventricular (LV) mechanical dyssynchrony. The initial results were all confirmed from studies using technetium-99m (Tc-99m) sestamibi or tetrofosmin as the radiotracers. The purpose of this study was to evaluate the feasibility of phase analysis in thallium-201 (Tl-201) gated SPECT MPI. Seventeen patients referred from a cardiology clinic for evaluation of coronary artery disease were studied. All patients underwent both Tl-201 and Tc-99m sestamibi gated SPECT MPI within 1 week. An additional 34 patients with Tl-201 gated SPECT and 22 patients with Tc-99m sestamibi gated SPECT, who had a low likelihood of coronary artery disease, normal LV function, and normal perfusion on MPI, were used as normal controls. LV dyssynchrony parameters, including phase standard deviation (PSD) and phase histogram bandwidth (PHB), were measured using a standard phase analysis tool and compared between Tl-201 and Tc-99m sestamibi images. The LV dyssynchrony parameters correlated well (r=0.93 for PSD and r=0.84 for PHB) between Tl-201 and Tc-99m sestamibi images. The dyssynchrony parameters of Tl-201 were significantly larger than those of Tc-99m sestamibi (PSD: 24.5±12.0 vs. 17.4±9.7, PTl-201 and Tc-99m sestamibi images showed concordant results. LV dyssynchrony parameters correlated well between Tl-201 and Tc-99m sestamibi images, even though the values were significantly larger for Tl-201 than for Tc-99m sestamibi. Tl-201 images showed results similar to those of Tc-99m sestamibi in the diagnosis of LV dyssynchrony.

  15. Comparison of the uptakes of Tc-99m MIBI and Tc-99m tetrofosmin in A549, an MRP-expressing cancer cell, in vitro and in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jeong Ah; Jeong, Shin Young; Seo, Myung Rang; Bae, Jin Ho; Ahn, Byeong Cheol; Lee, Kyu Bo; Lee, Jae Tae [School of Medicine, Kyungpook National Univ., Daegu (Korea, Republic of); Choi, Sang Woon; Lee, Byung Ho [Korea Institute of Chemical Technology, Daejon (Korea, Republic of)

    2003-12-01

    Uptakes of Tc-99m MIBI (MIBI) and Tc-99m tetrofosmin (tetrofosmin) in human non-small cell lung cancer A549, multidrug-resistance associated protein (MRP) expressing cell, were investigated in vitro and in vivo. Western blot analysis and immunohistochemistry were used for detetion of MRP in A549 cells with anti-MRPr1 antibody. Cellular uptakes of two tracers were evaluated at 100 {mu}M of verapamil (Vrp), 50 {mu}M of cyclosporin A (CsA) and 25 {mu}M of butoxysulfoximide (BSO) after incubation with MIBI and tetrofosmin for 30 and 60 min at 37.deg.C, using single cell suspensions at 1x10{sup 6} cells/ml. Radioactivities in supernatants and pellets were measured with gamma well counter. A549 cells were inoculated in each flanks of 24 nude mice. Group 1 (Gr1) and Gr3 mice were treated with only MIBI or tetrofosmin, and Gr2 and Gr4 mice were treated with 70mg/kg of CsA i.p. for 1 hour before injection of 370KBq of MIBI or tetrofosmin. Mice were sacrificed at 10, 60 and 240 min. Radioactivities of organs and tumors were expressed as percentage injected dose per gram of tissue (%ID/gm). Western blot analysis of the A549 cells detected expression of MRPr1 (190 kDa) and immunohistochemical staining of tumor tissue for MRPr1 revealed brownish staining in cell membrane but not P-gp. Upon incubating A549 cells for 60 min with MIBI and tetrofosmin, cellular uptake of MIBI was higher than that of tetrofosmin. Coincubation with modulators resulted in an increase in cellular uptakes of MIBI and tetrofosmin. Coincubation with modulators resulted in an increase in cellular uptakes of MIBI and tetorfosmin. Percentage increase of MIBI was higher than that of tetrofosmin with Vrp by 623% and 427%, CsA by 753% and 629% and BSO by 219% and 140%, respectively. There was no significant difference in tumoral uptakes of MIBI and tetrofosmin between Gr1 and Gr3. Percentage increases in MIBI (114% at 10 min, 257% at 60 min, 396% at 240 min) and tetrofosmin uptake (110% at 10 min, 205% at 60

  16. Optimisation of Simultaneous Tl-201/Tc-99m Dual Isotope Reconstruction with Monte-Carlo-Based Scatter Correction

    Directory of Open Access Journals (Sweden)

    Tuija Kangasmaa

    2012-01-01

    Full Text Available Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM- based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 105 simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 106 simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

  17. Optimisation of simultaneous tl-201/tc-99m dual isotope reconstruction with monte-carlo-based scatter correction.

    Science.gov (United States)

    Kangasmaa, Tuija; Kuikka, Jyrki; Sohlberg, Antti

    2012-01-01

    Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM-) based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC) simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 10(5) simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 10(6) simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

  18. Baseline Tc-99m DTPA renal scintigraphy as a predictor of outcome in children with urinary tract infection

    Energy Technology Data Exchange (ETDEWEB)

    Yun, J. G.; An, Y. S.; Lee, M. H.; Cho, C. W.; Yun, S. N.; Pai, G. S [Ajou University Medical Center, Suwon (Korea, Republic of)

    2004-07-01

    Tc-99m DTPA renal scintigraphy is useful in detecting urinary tract obstruction in patients with urinary tract infection (UTI). We evaluated the prognostic significance of baseline Tc-99m DTPA renal scintigraphy in children with UTI. Among children, who underwent both baseline/follow-up Tc-99m DMSA scintigraphies and baseline Tc-99m DTP A scintigraphy for evaluation of UTI, 32 patients with unilateral cortical defects on baseline Tc-99m DMSA scintigraphy were included in the study. The outcome of cortical defects was evaluated on follow-up Tc-99m DMSA scintigraphy by visual analysis. ROIs were drawn on the Tc-99m DPTA scintigraphy for calculation of ipsilateral to contralateral kidney ratio (ICR) at blood flow phase (< 60s, BFP) and cortical uptake phase (1-5 min, CUP). Median follow-up period of Tc-99m DMSA scintigraphy was 3.2 months (1.4 - 14 months). There were 24 patients with healing cortical defects and 8 with cortical scarring. Average ICRs of patients with healing defects were 1.11 {+-} 0.18 (0.44 - 1.57) at BFP and 0.97 {+-} 0.21 (0.31 - 1.28) at CUP, while those of patients with cortical scarring were 0.97 {+-} 0.47 (0.21 - 0.89) at BFP and 0.75 {+-} 0.49 (0.19 - 1.65) at CUP. ICR more than 0.9 was determined as a good prognostic indicator. The sensitivity, specificity, positive predictive value, and negative predictive value of ICR was 83.3%, 100%, 100% and 66.7% at BFP, and 79.0%, 62.5%, 86.4% and 50.0% at CUP. Ipsilateral to contralateral kidney ratio on baseline Tc-99m DPTA renal scintigraphy, especially at blood flow phase, is helpful in predicting outcome of children with UTI.

  19. Tc-99m-tetrofosmin scintigraphy: an alternative scintigraphic method for following up differentiated thyroid carcinoma--preliminary results.

    Science.gov (United States)

    Gallowitsch, H J; Kresnik, E; Mikosch, P; Pipam, W; Gomez, I; Lind, P

    1996-12-01

    The usefulness of the myocardial perfusion agent, Tc-99m-tetrofosmin (Myoview) in the follow-up of differentiated thyroid carcinoma was evaluated in a clinical study of 15 patients, primary treated with thyroidectomy and high-dose I-131-therapy (2960-3700 MBq). 12 with suspected recurrence and metastases and three patients without any suspicion and compared with other non-specific tracers like TI-201 and Tc-99m-sestamibi. Twelve patients with elevated thyroglobulin (Tg) levels of more than 10 ng/ml (group A), four of these had negative I-131 scans, and three patients with Tg levels less than 10 ng/ml (group B) were examined under TSH suppressive L-Thyroxine treatment. Whole body scans were taken with Tl-201 (74 MBq: 20 mn post injection), Tc-99m-sestamibi (370 MBq: 20-60 min post injection) and Tc-99m-tetrofosmin (370 MBq: 20-60 min post injection). Tumor/background ratios and optional time/activity analyses (up to 150 min post injection) were evaluated using the region of interest approach. Compared with Tl-201 (T/BG: 1.59, +/- 0.396). Tc-99m-tetrofosmin showed slightly but not significant better T/BG ratios and detection rates (T/BG: 1.76, +/- 0.345). Tc-99m-sestamibi (1.51, +/- 0.31 p = 0.05) showed significantly lower values than Tc-99m-tetrofosmin In the light of these results, scintigraphy with Tc-99m-tetrofosmin seems to be a possibly sensitive imaging modality in the follow-up of DTC with possible advantages concerning T/Bg ratio, background clearance, detection rate and dosimetry compared with Tl-201 and Tc-99m-sestamibi, especially in patients with elevated Tg level and no iodine uptake, but further investigations are needed to confirm our preliminary results.

  20. Evaluation of Mo99 and Tc99m Productions Based on a High-Performance Cyclotron

    Directory of Open Access Journals (Sweden)

    J. Esposito

    2013-01-01

    Full Text Available Following preliminary feasibility studies which started at Legnaro National Laboratories (LNL in 2011, the Italian National Institute for Nuclear Physics (INFN research activities are underway aiming at the alternative, accelerator-driven, Mo99/Tc99m production routes. One of the most promising approaches is to use 100Mo-enriched (i.e., >99% molybdenum metallic targets, bombarded with high-beam-current, high-energy proton cyclotrons. In order to get a comprehensive map of radionuclides expected, a detailed theoretical investigation has been carried out using the TALYS-TENDL 2012 excitation functions extended up to (p,6n, (p,p5n, and (p,2p4n levels. A series of quality parameters have thus been calculated both at the end of beam (EOB and at longer times. Results point out that accelerator-99Mo is of limited interest for a possible massive production because of the quite low specific activity with respect to reactor-99Mo. Accelerator-Tc99m quality parameters (i.e., radionuclidic purity (RNP, isotopic purity (IP, and specific activities calculated are instead quite close to the generator-Tc. Calculations at 15, 20, and 25 MeV have thus been performed to assess the best operative irradiation condition for Tc99m production while minimizing both the short-lived and long-lived Tc contaminant radionuclides. Although present in minimum quantities, Tc contaminants may indeed have an impact either on the pharmaceutical labeling procedures or on contributing to patient radiation dose during the diagnostic procedures.

  1. Reappraisal of Tc-99m DMSA scintigraphy for follow up in children with vesicoureteral reflux

    Energy Technology Data Exchange (ETDEWEB)

    Tsukamoto, Eriko; Morita, Koichi; Katoh, Chietsugu; Nakada, Kunihiro; Nonomura, Katsuya; Kakizaki, Hidehiro; Koyanagi, Tomohiko; Tamaki, Nagara [Hokkaido Univ., Sapporo (Japan). School of Medicine; Itoh, Kazuo

    1999-12-01

    We reviewed Tc-99m DMSA scintigraphy in children with vesicoureteral reflux (VUR) in order to assess whether repeated Tc-99m DMSA scans are necessary for the follow up of these patients. Ninety-seven children who were followed up for more than one year (1-7.4 years, average 2.8 years) after the first DMSA scan were included in the study. Fifty-one patients had been diagnosed as primary VUR and 46 as secondary VUR. Age at the first examination ranged from 0 to 14 years (average 5.1 years). Planar images were taken 2 hours after injection. The % renal uptake per injected dose (% RU) was calculated from posterior images. Kidneys in 11 patients (11.3%) changed morphologically during the follow up. Of these, new photon deficient areas (PD) were detected in only 4 patients (4.1%). All of these 4 patients had neurogenic bladder and were managed with self-catheterization. Of the remaining 7 patients, cortical thinning progressed in 5 patients (5.2%) and PDs resolved in 3 patients (3.1%). In one of these 7 patients, PD resolved in one kidney and cortical thinning progressed in the contralateral kidney. Of 97 patients reviewed, % RU decreased more than 20% during the follow up in 6 patients (6.2%). All were diagnosed as secondary VUR due to neurogenic bladder. % RU decreased only in the contracted kidneys at the initial scan. Two of them underwent renal transplantation because of severe renal failure. In conclusion, new PD rarely developed and % RU decreased in only a few patients during the follow up of children with VUR. Repeated Tc-99m DMSA scintigraphy therefore seems to have little benefit in the follow up of children with VUR. It should be performed in selected patients with high risk of urinary tract infection or renal failure. (author)

  2. Evaluation of Renal Function in Children by Tc-99m DTPA Scintigraphy

    Directory of Open Access Journals (Sweden)

    Sevin Ayaz

    2016-09-01

    Full Text Available Aim: Dynamic renal scintigraphy can demonstrate both structural and functional renal pathologies. Our aim was to evaluate renal functions in children by technetium-99m diethylenetriaminepentaacetic acid (Tc-99m DTPA dynamic renal scintigraphy, and todetermine the frequency of scintigraphically detectable atrophic kidneys. Material and Method: Dynamic renal scintigraphy studies of 17 children (12 males, five females with urinary system complaints, having a mean age of 6.15 ± 4.41 years, were included in this retrospective study. Images were obtained with a dual-head gamma camera after intravenous (IV injection of Tc-99m DTPA. Results: The functions of 34 kidneys were evaluated. Decreased perfusion of the left and right kidneys was detected in 35.3% (n=6/17 and 11.8% (n=2/17 of cases, respectively. Prolongation in Tmax of the left and right kidneys was shown in 52.9% (n=9/17 and 29.4% (n=5/17 of the cases, respectively. Glomerular filtration rate of the left and right kidneys was normal in 64.7% (n=11/17 and 88.2% (n=15/17 of cases, respectively. Delayed excretion of the left and right kidneys wasdetected in 29.4% (n=5/17 and 11.8% (n=2/17 of cases, respectively. Stasis of urine in the left and right kidneys which responded to IV diuretics wasdemonstrated in 58.8% (n=10/17 and 70.6% (n=12/17 of cases, respectively. Dynamic renal scintigraphy findings in favour of left and right renal atrophy were obtained in 17.6% (n=3/17 and 5.9% (n=1/17 of cases, respectively. Discussion: Dynamic renal scintigraphy with Tc-99m DTPA was found to be useful in the evaluation of renal functions of children and in determining the frequency of atrophic kidneys.

  3. Initial study with Tc99m antigranulocyte antibody (MAK-47) in detection sources of infection

    Energy Technology Data Exchange (ETDEWEB)

    Cwikla, J.B.; Buscombe, J.R.; Hilson, A.J. [Dept. of Nuclear Medicine and Medical Physics, Royal Free Hospital and School of Medicine, London (United Kingdom); Janoki, G.A. [FJC National Research Inst. for Radiology and Radiohygene, Dept. of Applied Radioisotopes, Budapest (Hungary)

    1997-12-31

    Antigranulocytes antibodies (AGAB) are antibodies directed against glycoprotein on the surface of granulocytes and as such provides in vivo cell labelling. They are easily labelled with Tc99m and comes a one step labelling technique. 20 patients have been studied 1 h and 4-6 hours after administration of 200 MBq of Tc99m AGAB (MAK-47). Less then 0.5 mg of antibody was given to each patients. Sites of uptake and outside of the reticular-endothelial system were reported as showing positive accumulation. Clinical results were confirmed by microbiological, pathological examinations, clinical follow-up and autopsy. There were 8 patients who had sites of infection confirmed by additional examination. All patients were visualized by Tc99m AGAB (MAK-47). There were 4 cases of osteomyelitis and septic arthritis and 4 cases of focal intra-abdominal infection. Two patients had uptake in non-infected/inflammatory arthritis, both in the knee. The remaining patients had true negative studies. The diagnostic accuracy of this study was as follows: sensitivity 100%, specificity 83%, positive predictive value (PPV) was 80% and negative predictive value (NPV) was 100%. Antigranulocyte antibody (MAK-47) seems to by promising tool in detecting focal infection in bone and soft tissue, except physiological accumulation in some parts of the body. It should be considered that antibodies can have non-specific uptake in non-infected, inflammation sites. It is easy to use and no had allergic reaction and HAMA antibody (human antimouse antibody). (author) 18 refs, 4 figs, 2 tabs

  4. Conceptual design of a new homogeneous reactor for medical radioisotope Mo-99/Tc-99m production

    Energy Technology Data Exchange (ETDEWEB)

    Liem, Peng Hong [Nippon Advanced Information Service (NAIS Co., Inc.) Scientific Computational Division, 416 Muramatsu, Tokaimura, Ibaraki (Japan); Tran, Hoai Nam [Chalmers University of Technology, Dept. of Applied Physics, Div. of Nuclear Engineering, SE-412 96 Gothenburg (Sweden); Sembiring, Tagor Malem [National Nuclear Energy Agency (BATAN), Center for Reactor Technology and Nuclear Safety, Kawasan Puspiptek, Serpong, Tangerang Selatan, Banten (Indonesia); Arbie, Bakri [PT MOTAB Technology, Kedoya Elok Plaza Blok DA 12, Jl. Panjang, Kebun Jeruk, Jakarta Barat (Indonesia)

    2014-09-30

    To partly solve the global and regional shortages of Mo-99 supply, a conceptual design of a nitrate-fuel-solution based homogeneous reactor dedicated for Mo-99/Tc-99m medical radioisotope production is proposed. The modified LEU Cintichem process for Mo-99 extraction which has been licensed and demonstrated commercially for decades by BATAN is taken into account as a key design consideration. The design characteristics and main parameters are identified and the advantageous aspects are shown by comparing with the BATAN's existing Mo-99 supply chain which uses a heterogeneous reactor (RSG GAS multipurpose reactor)

  5. Renal allograft accumulation of Tc-99m sulfur colloid: temporal quantitation and scintigraphic assessment

    Energy Technology Data Exchange (ETDEWEB)

    George, E.A.; Meyerovitz, M.; Codd, J.E.; Fletcher, J.W.; Donati, R.M.

    1983-08-01

    Renal allograft accumulation of Tc-99m sulfur colloid (TSC) was studied using visual assessment of scintigraphic displays and a quantitative temporal model in 210 examinations of 56 transplant recipients. The quantitative temporal model related the immediate pool of the radioagent in the transplant to the fixed allograft accumulation of TSC at 20 minutes after administration. Examinations performed less than 3 days after grafting or steroid pulse therapy were excluded. Rejection was established by clinical and biochemical evaluation in all 84 examinations that showed acute or choronic allograft rejection. Rejection was accurately diagnosed by visual scintigraphic assessment in 82% of the established cases.

  6. Discordant results in Tc-99m tetrofosmin and Tc-99m sestamibi parathyroid scintigraphies; Resultados discordantes em cintilografias das paratireoides realizadas com tetrofosmin-99mTc e com sestamibi-99mTc

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, Paulo Schiavom; Domingues, Fernanda C.; Santi Costa, Michele; Brandao, Cynthia; Oliveira, Marco A.C. de; Vieira, Jose G.H. [Fleury - Centro de Medicina Diagnostica, Sao Paulo, SP (Brazil)]. E-mail: paulo.duarte@fleury.com.br

    2007-10-15

    Parathyroid scintigraphies have been used to detect pathological parathyroid glands either before as well as after the parathyroid resection surgery in patients with hyperparathyroidism. One of the most utilized techniques to perform the studies is the double-phase images with Tc-99m sestamibi, which has been shown to be very accurate in the localization of enlarged parathyroid glands. Similar to Tc-99m sestamibi, Tc-99m tetrofosmin is a radiopharmaceutical initially developed to perform myocardial perfusion study that has been used to perform parathyroid scintigraphies. Although most of the papers suggest that the overall sensitivities of both radiopharmaceuticals are similar, there are some papers questioning the accuracy of Tc-99m tetrofosmin to detect abnormal parathyroid glands. In the present article, we report a case with discordant results by both methods. (author)

  7. Tc-99m ECD brain SPECT in MELAS syndrome and mitochondrial myopathy: comparison with MR findings

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Joon; Ryu, Young Hoon; Jeon, Tae Joo; Kim, Jai Keun; Nam, Ji Eun; Yoon, Pyeong Ho; Yoon, Choon Sik; Lee, Jong Doo [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    1998-08-01

    We evaluated brain perfusion SPECT findings of MELAS syndrome and mitochondrial myopathy in correlation with MR imaging in search of specific imaging features. Subjects were five patients (four females and one male; age range, 1 to 25 year) who presented with repeated stroke like episodes, seizures or developmental delay or asymptomatic but had elevated lactic acid in CSF and serum. Conventional non-contrast MR imaging and Tc-99m-ethyl cysteinate dimer (ECD) brain perfusion SPECT were performed and imaging features were analyzed. MRI demonstrated increased T2 signal intensities in the affected areas of gray and white matters mainly in the parietal (4/5) and occipital lobes (4/5) and in the basal ganglia (1/5), which were not restricted to a specific vascular territory. SPECT demonstrated decreased perfusion in the corresponding regions of MRI lesions. In addition, there were perfusion defects in parietal (1 patient), temporal (2), and frontal (1) lobes and basal ganglia (1) and thalami (2). In a patient with mitochondrial myopathy who had normal MRI, decreased perfusion was noted in left parietal area and bilateral thalami. Tc-99m ECD SPECT imaging in patients with MELAS syndrome and mitochondrial myopathy showed hypoperfusion of parieto-occipital cortex, basal ganglia, thalamus and temporal cortex, which were not restricted to a specific vascular territory. There were no specific imaging features on SPECT. The significance of abnormal perfusion on SPECT without corresponding MR abnormalities needs to be evaluated further in larger number of patients.

  8. Evaluation of RI images of hepatic blood flow using Tc-99m PMT

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Hiromichi; Iwasaki, Naoya; Ichikawa, Kesato

    1988-03-01

    To evaluate the clinical significance of RI images of hepatic blood flow using Tc-99m-PMT, analysis of the RI images and estimation of hepatic blood flow were carried out in patients with various liver diseases (37 cases). After intravenous injection of Tc-99m-PMT, hepatic accumulation curve of ROI positioned at whole liver area and time activity curve of ROI positioned at celiac artery were obtained through scintillation camera images with the computer-analysed system. Hepatic blood flow coefficient (K) was calculated from the hepatic accumulation curve. Based on the differential curve calculated from the time activity curve, chronological images of arterial, portal, parenchymal and saturated parenchymal phases were obtained. Results ; 1) K was 0.50 + 0.04, 0.35 + 0.02 and 0.26 + 0.04/min in normal type, CH type and LC type respectively. These coefficients well correlated with clinical severity of hepatic diseases. 2) Perfusional phase images of the liver became poorer in accordance with progression of liver disease, while images of spleen, portal venous system and collateral channels were more clearly obtained in liver cirrhosis. This method was shown to have a potential to understanding of severity of liver disease and hepatic blood flow dynamics.

  9. Changes in renal uptake of Tc-99m methylene diphosphonate (MDP) in stone-forming rats

    Energy Technology Data Exchange (ETDEWEB)

    McAfee, J.G.; Thomas, F.D.; Roskopf, M.; Ritter, K.; Lyons, B.; Lilien, O.M.; Schoonmaker, J.E.

    A pyridoxine (vitamin B6)-deficient diet in rats was used as a model of early renal lithiasis to find out if stone-formers could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in stone-formers. If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the stone-forming animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in stone-formers beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran.

  10. SUV measurement of normal vertebrae using SPECT/CT with Tc-99m methylene diphosphonate

    Science.gov (United States)

    Kaneta, Tomohiro; Ogawa, Matsuyoshi; Daisaki, Hiromitsu; Nawata, Shintaro; Yoshida, Keisuke; Inoue, Tomio

    2016-01-01

    The purpose of this study is to perform quantitative measurement based on the standardized uptake value (SUV) of the uptake of Tc-99m methylene diphosphonate (MDP) in the normal vertebrae using a single photon emission tomography (SPECT)/computed tomography (CT) scanner. A retrospective study of patients with cancer or joint disorders was performed. We acquired data for a group of 29 patients (8 women and 21 men; mean age, 68.2 ± 6.7 years; age range, 44-87 years) undergoing bone SPECT/CT scans with Tc-99m MDP between September and October 2015. Various SUVs were calculated based on body-weight, lean-body-weight (lbw), Japanese lean-body-weight (jlbw) and Japanese bone-mineral-content (jbmc). SUVs of normal vertebrae showed a wide range of values. Among these, the maximum body-weight based SUV showed the lowest coefficient of variation. The SUVs also showed relatively small intra-subject variability. In addition, all SUVs showed moderate and significant correlation with height. Moreover, lbw-, jlbw-, and jbmc-based SUVs of men were significantly higher than those of women. In conclusions, SUVs of normal vertebrae showed a relatively large inter-individual variability and small intra-individual variability. As a quantitative imaging biomarker, SUVs might require standardization with adequate reference data for the same subject to minimize variability. PMID:27766184

  11. Drug-induced modulation of Tc-99m pyrophosphate tissue distribution: what is involved

    Energy Technology Data Exchange (ETDEWEB)

    Wahner, H.W.; Dewanjee, M.K.

    1981-06-01

    More than ten years after their introduction, Tc-99m-labeled phosphates and phosphonates (TcP) continue to be of interest to the investigator and to hold promise for new clinical applications in the future. Initially, TcP compounds were valued because of their bone-seeking properties. Emphasis shifted from bone to soft tissue when Bonte et al. introduced Tc-99m-labeled pyrophosphate (TcPPi) for myocardial infarct scanning. Detailed information about TcPPi uptake in ischemic and necrotic myocardial tissue at the subcellular level has accumulated. Therefore, understanding of the mechanism of TcPPi uptake in infarcted myocardium is more detailed than understanding of uptake by bone. A new, and potentially powerful, approach to the use of TcP is being proposed by Carr et al. The authors attempt to modulate favorably the tissue distribution of TcPPi by prior administration of drugs in pharmacological quantities. The authors demonstrate that uptake of TcPPi can be enhanced in the necrotic myocardium, uptake by bone can be reduced, and the lesion-to-blood ratio can be altered favorably when vitamin D/sub 3/ or desoxycorticosterone acetate (DOCA) is administered in pharmacological doses before the TcPPi injection. A short review is presented of background information helpful for interpreting the drug effects on TcPPi uptake in bone or necrotic myocardial tissue.

  12. Tc-99m DTPA scans in renal allograft rejection and cyclosporine nephrotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Gedroyc, W.; Taube, D.; Fogleman, I.; Neild, G.; Cameron, S.; Maisey, M.

    1986-11-01

    Renal allograft dysfunction arising from rejection or cyclosporine (CsA) nephrotoxicity can currently only be distinguished reliably by allograft biopsy. We have assessed Technetium (Tc)-99m diethylamine pentacetic acid (DTPA) scanning in 30 CsA-treated patients with allograft dysfunction. Scintigrams were performed during 20 biopsy-proved episodes of rejection and during 14 episodes of CsA nephrotoxicity. These results were compared with the scintigrams of 15 allografts showing stable function. Quantitative indices expressing allograft perfusion (flow index) and function (uptake index) derived from the DTPA scintigrams showed no significant differences between the groups of patients with rejection, CsA nephrotoxicity, or stable or improving function. Similarly, the flow and uptake indices of individual allografts obtained during periods of stable or improving function and then during episodes of dysfunction due to rejection or CsA nephrotoxicity did not significantly change. We conclude that Tc-99m DTPA scintigrams are of limited value in the management of allograft dysfunction in patients immunosuppressed with CsA.

  13. Tc-99m-tetrofosmin scintigraphy: An alternative scintigraphic method for following up differentiated thyroid carcinoma - preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Gallowitsch, H.J. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Kresnik, E. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Mikosch, P. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Pipam, W. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Gomez, I. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology; Lind, P. [LKH Klagenfurt (Austria). Dept. of Nuclear Medicine and Special Endocrinology

    1996-12-01

    Aim: The usefulness of the myocardial perfusion agent, Tc-99m-tetrofosmin (Myoview{sup R}) in the follow-up of differentiated thyroid carcinoma was evaluated in a clinical study of 15 patients, primary treated with thyroidectomy and high-dose I-131-therapy (2960-3700 MBq), 12 with suspected recurrence and metastases and three patients without any suspicion and compared with other non-specific tracers like Tl-201 and Tc-99m-sestamibi. Method: Twelve patients with elevated thyroglobulin (Tg) levels of more than 10 ng/ml (group A), four of these had negative I-131 scans, and three patients with Tg levels less than 10 ng/ml (group B) were examined under TSH suppressive L-Thyroxine treatment. Whole body scans were taken with Tl-201 (74 MBq; 20 min post injection), Tc-99m-sestamibi (370 MBq; 20-60 min post injection) and Tc-99m-tetrofosmin (370 MBq; 20-60 min post injection). Tumor/background ratios and optional time/activity analyses (up to 150 min post injection) were evaluated using the region of interest approach. Results: Compared with Tl-201 (T/BG: 1.59{+-}0.396), Tc-99m-tetrofosmin showed slightly but not significant better T/BG ratios and detection rates (T/BG: 1.76, {+-}0.345). Tc-99m-sestamibi (1.51, {+-}0.31 p=0.05) showed significantly lower values than Tc-99m-tetrofosmin. Conclusion: In the light of these results, scintigraphy with Tc-99m-tetrofosmin seems to be a possibly sensitive imaging modality in the follow-up of DTC with possible advantages concerning T/Bg ratio, background clearance, detection rate and dosimetry compared with Tl-201 and Tc-99m-sestamibi, especially in patients with elevated Tg level and no iodine uptake, but further investigations are needed to confirm our preliminary results. (orig.) [Deutsch] Ziel: Die Verwendbarkeit des myokardialen Perfusionstracers Tc-99m-Tetrofosmin (Myoview{sup R}) fuer die Nachsorge des differenzierten Schilddruesenkarzinoms wurde in einer Pilotstudie an primaer operierten und radiojodtherapierten Patienten

  14. Comparison of thallium-201 scan and Tc-99m sestamibi scan in the differential diagnosis of breast mass

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Ihn Ho; Won, Kyu Jang; Lee, Hyung Woo; Lee, Soon Jung [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    1999-02-01

    We performed this study to compare Tl-201 and Tc-99m MIBI scans for the differentiation of malignant from benign breast mass. Thirty-eight female patients underwent Tl-201 breast scan and thirty-two of them also underwent Tc-99m MIBI scan of the breast. After intravenous injection of 74-111 MBq of Tl-201, early (10 minutes) and delayed (3 hours) images were obtained. Then, 555-740 MBq of Tc-99m MIBI was injected and images after 30 minutes were obtained. We compared Tl-201 and Tc-99m MIBI scans with pathologic results. Twenty-three patients were confirmed to have infiltrating duct carcinoma and fifteen patients to have benign breast mass by excisonal biopsy. The sensitivity of early and delayed Tl-201 scan and Tc-99m MIBI scan in the detection of malignant breast lesion were 100% (23/23), 82% (18/22), and 90% (18/20), respectively. The sensitivity of early Tl-201 scan was significantly higher than that of delayed Tl-201 scan, (p<0.05). The specificity of early and delayed Tl-201 scan and Tc-99m MIBI scan were 73% (11/15), 73% (11/15) and 83% (10/12), respectively (p: not significant). Three patients out of nine with fibroadenoma and one patient with atypical duct hyperplasia were false positive in both early and delayed Tl-201 scans. The size of fibroadenoma with false positive in early and delayed Tl-201 scan (4 cases) was larger than that of 11 fibroadenoma with true negative scan (p<0.01). Metastatic axillary lymph node involvement was present in fifteen patients. The sensitivity to detect metastatic nodes was 38% (5/13) for early Tl-201 images, 15% (2/13) for delayed Tl-201 images, 58% (7/12) for Tc-99m MIBI planar images and 67% (4/6) for Tc-99m MIBI SPECT. The sensitivity of Tc-99m MIBI planar or SPECT was significantly higher than that of delayed Tl-201 images (p<0.05). Early Tl-201 and Tc-99m MIBI scan are useful noninvasive methods to differentiate malignant from benign mass of breast. Tc-99m MIBI scan was sensitive in detecting axillary lymph node

  15. Evaluation of lung epithelial permeability in the volatile substance abuse using Tc-99m DTPA aerosol scintigraphy.

    Science.gov (United States)

    Cayir, Derya; Demirel, Koray; Korkmaz, Meliha; Koca, Gokhan

    2011-10-01

    Chronic inhalant use is associated with significant toxic effects, including neurological, renal, hepatic, and pulmonary damage. However, there is a paucity of reports regarding respiratory complications in inhalant abusers. The aim of this study was to evaluate pulmonary epithelial permeability in the volatile substance abuse (VSA) using Tc-99m DTPA aerosol scintigraphy. This study included 18 patients with volatile substance abuse and 18 volunteer controls. All of patients and controls were smokers. Tc-99m DTPA aerosol scintigraphy was performed in all cases. Time-activity curves from each lung were generated and clearance half-time (T(1/2)) of Tc-99m DTPA were calculated. T(1/2) of whole lung was calculated as a mean of the T(1/2) of left and right lung. The T(1/2) values of Tc-99m DTPA clearance in the substance abusers were significantly decreased as compared to the control group with respective mean values of 28.86 ± 8.44, and 62.14 ± 26.12 min (p = 0.001). It was seen Tc-99m DTPA clearance from lung was faster as the duration of substance abuse was increased. Tc-99m DTPA pulmonary clearance is markedly accelerated in the volatile substance abuse. This suggests that inhalant abuse of substance may produce abnormalities in pulmonary alveolo-capillary membrane function.

  16. Estudo experimental de linfonodo sentinela na mama da cadela com azul patente e Tecnécio Tc99m Experimental study of the sentinel lymph node in the dog breast using blue dye and technetium Tc99m

    Directory of Open Access Journals (Sweden)

    Luiz Gonzaga Porto Pinheiro

    2003-12-01

    Full Text Available Pesquisa do Linfonodo Sentinela (LS tem se mostrado efetiva na avaliação axilar nas portadoras de neoplasia mamária. O LS negativo torna desnecessário o esvaziamento axilar. OBJETIVO: Identificar o LS da região subareolar da mama em cadelas utilizando corante azul patente (AP, Tecnécio Tc99m ou a associação de ambas as técnicas e compará-las quanto à sensibilidade na detecção do linfonodo sentinela. MÉTODOS: Foram estudadas dezessete cães fêmeas. Um total de 55 mamas foram analisadas. Utilizou-se AP (2,5%/0,5 ml e/ou Tc99m (1,0 mC/0,8ml para identificação do LS. A aplicação do Tc99m era realizada duas horas antes da realização do experimento. O AP era injetado na região subareolar da mama. Localizado o LS, realizava-se sua exérese. RESULTADOS: Dos 44 linfonodos em que se utilizou AP, pôde-se verificar que 40 estavam corados (90,90%. Dos 48 linfonodos em que se utilizou Tc99m, 47 linfonodos estavam radioativos (97,91% (p=0.18; k= - 0.067. Nas 37 mamas em que se associou AP ao Tc99m, apesar de 02 linfonodos não estarem corados, todos estavam radioativos (AP vs AP+Tc: p=0.12; k=0.083; Tc vs AP+Tc: p=1.0; k=0.018. CONCLUSÃO: O Tc99m e o corante azul patente, isolados ou associados, prestam-se à identificação do LS da mama do animal.The sentinel lymph node research (SLN has been effective in the evaluation of nodal status in patients with breast cancer. A negative SLN makes an axillary lymphadenectomy unnecessary. PURPOSE: To identify the SLN of the subareolar region in female dog breasts using blue dye (BD, Technetium (Tc99m or the association of both techniques and to compare their sensibility in the detection of the SLN. METHODS: Seventeen female dogs were studied. 55 breasts were analyzed. DB and/or Tc99m were used for the identification of SLN. Tc99m was introduced two hours before the experiment. BD was introduced some minutes before the procedure. Once the SLN was localized its dissection was performed. RESULTS

  17. Exanthema after a stress Tc-99m sestamibi study: continue with a rest sestamibi study?

    DEFF Research Database (Denmark)

    Hesse, Birger; Vinberg, Niels; Mosbech, Holger

    2011-01-01

    Purpose:  A mild allergic reaction assumed to be caused by injection of Tc-99m sestamibi for a stress myocardial perfusion imaging (MPI) is presented. We want to discuss the risk involved in completing the MPI with another sestamibi injection, and the precautions and possible treatment in case of......, but anaphylactic reactions have been reported and may be life threatening. If repeated administration of the radio-pharmaceutical must be given, the prophylactic and therapeutic interventions should follow general international guidelines for allergic reactions........ After prophylactic treatment with antihistamine and corticosteroid, an uneventful rest MPI was performed. Discussion and conclusion:  International recommendations or guidelines related to treatment of AEs after nuclear medicine studies do not exist. Serious AEs in nuclear medicine are very rare...

  18. Tc-99m DTPA renal function tests and diuretic renogram in the dilated upper urinary tract

    Energy Technology Data Exchange (ETDEWEB)

    Sakagami, Yoshinari; Yamaguchi, Osamu; Suzuki, Takayuki; Kameoka, Hiroshi; Shiraiwa, Yasuo; Suzuki, Akira (Fukushima Medical Coll. (Japan))

    1992-09-01

    The authors studied patients with dilated upper urinary tracts (16 patients) using radioisotopic split renal function tests and diuretic renogram with [sup 99]mTc-diethylenetriaminepentaacetic acid (Tc-99m DTPA). The etiology was ureteropelvic function stenosis, 11; primary megaureter, 3; ureteral stenosis, 1; and aberrant vessel, 1. Response to diuresis was classified into 3 groups: i.e., obstructive pattern, non-obstructive pattern and partial obstructive pattern. In the non-obstructive group, split renal function was good, and thus an operation was not indicated. In the obstructive group, split renal function was significantly decreased and these patients underwent surgery. In the partial obstructive group, if function of the obstructed kidney was approximately the same as that of the non-obstructed side, then surgery was considered unnecessary. (author).

  19. Dumbbell Gallbladder Cholecystitis on Tc-99m Diisopropyliminodiacetic acid Hepatobiliary Imaging

    Science.gov (United States)

    Fakhri, Asif Ali; Rodrigue, Paul David; Hussain, Aun; Taiyebi, Abbas

    2017-01-01

    We present a case of a 79-year-old immunocompromised female admitted for abdominal pain and sepsis, who had an abdominal computed tomography (CT) showing distal gallbladder fundus wall thickening, pericholecystic edema, and a right posteroinferior hepatic abscess. Subsequent hepatobiliary scintigraphy with Tc-99m diisopropyliminodiacetic acid showed gallbladder filling of the proximal gallbladder fundus, yet no radiotracer filling of the distal gallbladder fundus. Further correlation with the initial CT showed a partial gallbladder stricture and a resultant altered morphology resembling a dumbbell-shaped gallbladder. Percutaneous cholangiogram also confirmed this dumbbell morphology. Nonfilling of radiotracer into the distal end of the dumbbell gallbladder correlating with CT findings of focal gallbladder inflammation indicated that there was a focal inflammation suggesting a distal dumbbell gallbladder cholecystitis. This case demonstrates a unique finding of focal inflammatory pathology involving an anatomic variant - the dumbbell-shaped gallbladder, and the challenges this anatomic variant presents in hepatobiliary scintigraphy image interpretation. PMID:28242983

  20. Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Peng, N.J.; Tsay, D.G. [Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung (Taiwan); Liu, R.S. [Department of Nuclear Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei (Taiwan); Li, J.Y.; Kong, K.W. [Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung (Taiwan); Kwok, C.G.; Strauss, H.W. [Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, CA (United States)

    2000-01-01

    We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a stroke-like episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid. (orig.)

  1. Renal allograft accumulation of Tc-99m sulfur colloid: temporal quantitation and scintigraphic assessment

    Energy Technology Data Exchange (ETDEWEB)

    George, E.A.; Meyerovitz, M.; Codd, J.E.; Fletcher, J.W.; Donati, R.M.

    1983-08-01

    Renal allograft accumulation of Tc-99m sulfur colloid (TSC) was studied using visual assessment of scintigraphic displays and a quantitative temporal model in 210 examinations of 56 transplant recipients. The quantitative temporal model related the immediate pool of the radioagent in the transplant to the fixed allograft accumulation of TSC at 20 minutes after administration. Examinations performed less than 3 days after grafting or steroid pulse therapy were excluded. Rejection was established by clinical and biochemical evaluation in all 84 examinations that showed acute or chronic allograft rejection. Rejection was accurately diagnosed by visual scintigraphic assessment in 82% of the established cases; this improved to 99% with relative temporal quantitation analysis. Sensitivity improved from 78% by visual examination to 95% with temporal quantitation and specificity improved from 83% to 100%.

  2. Tc-99m HIG Scintigraphy in Detection of Active Inflammation in Ankylosing Spondylitis

    Directory of Open Access Journals (Sweden)

    Özhan Özdoğan

    2011-08-01

    Full Text Available Objective: The diagnosis of active inflammation in ankylosing spondylitis (AS is crucial for treatment to delay possible persistent deformities. There are no specific laboratory tests and imaging methods to clarify the active disease. We evaluated the value of Tc-99m human immunoglobulin (HIG scintigraphy in detection of active inflammation. Material and Methods: Twenty-nine patients were included. Tc-99m methylenediphosphonate bone (MDP and HIG scintigraphies were performed within 2-5 day intervals. Two control groups were constituted both for MDP and HIG scintigraphies. Active inflammation was determined clinically and by serologic tests. Both scintigraphies were evaluated visually. Sacroiliac joint index values (SII were calculated. Results: Active inflammation was considered in five (sacroiliitis in 2, sacroiliitis-spinal inflammation in 1, achilles tendinitis in 1, arthritis of coxafemoral joints in 1 patients. HIG scintigraphy demonstrated active disease in all 3 patients with active sacroiliitis. But, it was negative in the rest. The other 2 active cases were HIG negative. Right and left SII obtained from HIG scintigraphy was higher (p<0.05 in clinically active patients than inactive patients. There was not any significant difference between patients with inactive sacroiliitis and normal controls. Right and left SII obtained from bone scintigraphy was higher (p<0.05 in patient group than in control group. Conclusion: Clinically inactive AS patients, behave no differently than normal controls with quantitative sacroiliac joint evaluation on HIG scintigraphy. HIG scintigraphy may be valuable for evaluation of sacroiliac joints in patients with uncertain laboratory and clinical findings. (MIRT 2011;20:52-58

  3. Complicating osteomyelitis imaged with Tc-99m MDP, In-111 granulocytes, and Ga-67 citrate

    Energy Technology Data Exchange (ETDEWEB)

    Schauwecker, D.S.; Park, H.M.; Mock, B.H.; Burt, R.W.; Kernick, C.B.; Ruoff, A.C. III; Sinn, H.J.; Wellman, H.N.; Vamc, R.L.R.

    1984-01-01

    Gallium-67 and 3-phase bone scan (3P) studies, though very sensitive, are not very specific in evaluating suspected osteomyelitis (OM) which is superimposed upon other diseases that cause increased bone turnover (IBT). The authors compared In-111 acetylacetone labeled granulocytes (In-111) GRAN) with 3P in 57 such patients; 29 of these patients had Ga-67 studies as well. In-111 GRAN had a sensitivity of 100% in acute OM, 62% in chronic OM, and a specificity of 96%. Gallium-67 ruled out OM when the study was normal; it diagnosed OM when the relative uptake of Ga-67 exceeded the uptake of Tc-99m MDP, or when the skeletal distribution of Ga-67 was different from that of the TC-99m MDP. Unfortunately, these criteria were met in only 28% of the subjects. The simple approach of increased Ga-67 activity meant OM gave a sensitivity of 100%, but an unacceptable specificity of 38%. Chronic cellulitis or long-standing decubiti were seldom detected by IN-111 GRAN. Clinically obvious soft tissue infections or cellulitis were seen with In-111 GRAN 27% of the time, and 17% of the time with Ga-67. The authors conclude that when added to 3P, In-111 GRAN provided more useful information than did Ga-67. A combination of all 3 studies did not significantly increase the diagnostic yield. Performing In-111 GRAN without 3P in patients with IBT is not recommended since the 3P provides anatomic information that aids in the differentiation of OM from soft tissue infections.

  4. Double-phase Tc-99m tetrofosmin parathyroid scan in hyperparathyroidism: comparison with ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Soo; Kim, Sang Yoon [Daegu Fatima Hospital, Daegu (Korea, Republic of); Zeon, Seok Kil; Won, Kyoung Sook [School of Medicine, Keimyung University, Daegu (Korea, Republic of)

    2004-07-01

    This study was performed to evaluate the utility of double-phase Tc-99m Tetrofosmin(TF) parathyroid scan in the detection of pathologic lesions of primary hyperparathyroidism, and comparison with the ultrasonography(US). The double phase TF parathyroid scan of the anterior neck including upper mediastinum with 800 MBq TF were acquired at ten minutes (early phase) and at two hours (delayed phase) after radiopharmaceutical injection, in 24 consecutive patients under the clinical impression of primary hyperparathyroidism and hypercalcaemia. The images were evaluated for abnormal focal areas of increased tracer localization in the anterior neck and superior mediastinum in early phase, and visualization of parathyroid gland radioactivity after wash-out of the thyroid gland radioactivity in delayed phase. US of the anterior neck including upper mediastinum was performed by a diagnostic radiologist in 24 consecutive patients, within one week before or after the scan. The findings of double phase TF parathyroid scan and US were compared with the pathologic results. Ten of 24 patients were surgically explored and pathologic results showed eight adenomas and two hyperplasia. The double phase TF parathyroid scan showed positive findings in seven patients of eight adenomas and one patient of two hyperplasia patients. US image showed positive findings in six patients of eight adenomas and no positive findings of two hyperplasia. The sensitivity of the double phase TF scan for detection of the causes of the primary hyperparathyroidism was 80% and US was 60%. The double phase Tc-99m Tetrofosmin parathyroid scan showed higher sensitivity in detection of the pathologic lesions of primary hyperparathyroidism than ultrasonography.

  5. Statistical parametric mapping of Tc-99m HMPAO SPECT cerebral perfusion in the normal elderly

    Energy Technology Data Exchange (ETDEWEB)

    Turlakow, A.; Scott, A.M.; Berlangieri, S.U.; Sonkila, C.; Wardill, T.D.; Crowley, K.; Abbott, D.; Egan, G.F.; McKay, W.J.; Hughes, A. [Austin and Repatriation Medical Centre, Heidelberg, VIC (Australia). Departments of Nuclear Medicine and Centre for PET Neurology and Clinical Neuropsychology

    1998-06-01

    Full text: The clinical value of Tc-99m HMPAO SPECT cerebral blood flow studies in cognitive and neuropsychiatric disorders has been well described. Currently, interpretation of these studies relies on qualitative or semi- quantitative techniques. The aim of our study is to generate statistical measures of regional cerebral perfusion in the normal elderly using statistical parametric mapping (Friston et al, Wellcome Department of Cognitive Neurology, London, UK) in order to facilitate the objective analysis of cerebral blood flow studies in patient groups. A cohort of 20 healthy, elderly volunteers, aged 68 to 81 years, was prospectively selected on the basis of normal physical examination and neuropsychological testing. Subjects with risk factors, or a history of cognitive impairment were excluded from our study group. All volunteers underwent SPECT cerebral blood flow imaging, 30 minutes following the administration of 370 MBq Tc-99m HMPAO, on a Trionix Triad XLT triple-headed scanner (Trionix Research Laboratory Twinsburg, OH) using high resolution, fan-beam collimators resulting in a system resolution of 10 mm full width at half-maximum (FWHM). The SPECT cerebral blood flow studies were analysed using statistical parametric mapping (SPM) software specifically developed for the routine statistical analysis of functional neuroimaging data. The SPECT images were coregistered with each individual`s T1-weighted MR volume brain scan and spatially normalized to standardised Talairach space. Using SPM, these data were analyzed for differences in interhemispheric regional cerebral blood flow. Significant asymmetry of cerebral perfusion was detected in the pre-central gyrus at the 95th percentile. In conclusion, the interpretation of cerebral blood flow studies in the elderly should take into account the statistically significant asymmetry in interhemispheric pre-central cortical blood flow. In the future, clinical studies will be compared to statistical data sets in age

  6. Tc-99m ECD brain SPET in the evaluation of dementia for institutionalized elderly patients

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myoung Hoon; Park, Chan H.; Yoon, Seok Na.; Hwang, Kyung Hoon [College of Medicine, Ajou Univ., Suwon (Korea, Republic of)

    2001-07-01

    Dementia is one of the clinically recognized indications of regional cerebral blood flow (rCBF) measurement by Tc-99m ECD brain SPET (Single Photon Emission Tomography). There is only limited number of institutions for elderly demented patients who are institutionalized in Korea and SPET is nor available at these institutions. The aim of the study is to evaluate rCBF SPET findings of the patients from such an institution. Thirty-one patients were reffered for rCBF SPET from Yongin Hyoja Hospital, Yongin. They were screened using NINCDS-ADRDA criteria for probable Alzheimers disease (AD) and dementia severity was assumed by the Mini-Mental State examination. In a quite, dim light room, patients were injected with 740 mBq (20mCi) Tc-99m ethyl cysteinate dimmer (ECD), Neurolite R, Dupont Pharmaceuticals, Billerica, MA, USA). SPET was acquired using fanbeam collimators and triple-head gamma camera (MultiSPECT III, Siemens medical systems. Inc. Hoffman Estates, III.USA). SPET was done one hour after the tracer injection and most of the patients needed sedation 30 minutes before the scan. SPET was evaluated visually by 2 nuclear medicine physicians blinded to clinical information. The SPET scans of 31 patients revealed 3 typical AD, 9 atypical AD patterns. Other dementia patterns were 4 cases of frontotemporal lobe dementia, 5 cases of frontal lobe dementia and 2 multifocal infarctions. Only cerebral atrophy is depicted in 8 patients and normal SPECT findings was noted in one patient. Patients who are institutionalized for dementia have varying SPET patterns as expected and SPET findings are useful in the management of these patients with more clearer clinical insight.

  7. CT of acute pyelonephritis in children : comparison with Tc-99m DMSA scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sun Wha; Baek, Seung Yeon; Lee, Seung Joo [Ewha University, Seoul (Korea, Republic of). Coll. of Medicine

    1998-05-01

    The purpose of the study was to compare CT with scintigraphy in the detection of parenchymal lesions of acute pyeolonephritis in children, and to assess the diagnostic value of CT. This study involved 32 children with acute pyelonephritis; their ages ranged from 1 month to 10 years. Renal Ct, Tc-99m DMSA planar and SPECT images, and medical records were retrospectively reviewed. We evaluated the number, size, shape, density, and location of pyelonephritis lesions, as seen on CT and scintigraphic images. In 43 involved kidneys, 193 parenchymal lesions of acute pyelonephritis were identified. The results of CT were abnormal in 42 kidneys (98%), and those of scintigraphy , in 39 (91%). CT showed single or multiple hypoenhancing parenchymal lesions; these were streaky (n=151), wedge-shaped (n=34), or oval (n=8), and ranged from about 3 - 30 mm in maximum diameter. Abscess (n=5), renal fascial thickening (n=6) and thickening of the bridging septae (n=7) were associated. Scintigraphic findings were more precisely identified on SPECT than on planar images. For the detection of 55 of 193 pyelonephritis lesions, CT was more sensitive than scintigraphy; 29 of the 55 lesions were less than 5 mm in diameter. For the detection of phyelonephritic lesions, particularly smaller ones, and for the evaluation of complications such as abscess formation, CT is more sensitive than Tc-99m DMSA scintigraphy. We conclude that in children with subtle scintigraphic findings who are in serious clinical condition or in whom complications are suspected, CT is a useful tool for assessing a therapeutic plan and the prognosis of acute pyelonephritis. (author). 19 refs., 1 tab., 4 figs.

  8. Reverse redistribution of Tc-99m-tetrofosmin in exercise myocardial SPECT in patients with hypertrophic cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sugihara, Hiroki; Taniguchi, Yoko; Kinoshita, Noriyuki [Kyoto Prefectural Univ. of Medicine (Japan)] [and others

    1998-10-01

    We examined the usefulness of Tc-99m-tetrofosmin in detecting exercise induced perfusion abnormalities in patients with hypertrophic cardiomyopathy (HCM) and to clarify time-related changes in myocardial distribution of Tc-99m-tetrofosmin after a single injection. We studied 44 consecutive patients with HCM by means of exercise/rest Tc-99m-tetrofosmin single photon emission computed tomography (SPECT). After injecting 370 MBq of Tc-99m-tetrofosmin at the peak exercise, the early SPECT imaging was performed at 30 min (EX-30) and the delayed imaging at 180 min (EX-180). Immediately after the delayed imaging, 740 MBq of Tc-99m-tetrofosmin was injected in the resting state, and the rest SPECT imaging was performed 30 min later. Exercise-induced regional perfusion defects and/or apparent reversible left ventricular cavity dilation were identified in 26 (68.2%) of the 44 patients. When EX-30 images and EX-180 images were compared, reverse redistribution was confirmed in 36 patients (81.8%). Reverse redistribution was detected most frequently in the septal portion of the anterior wall, followed by the septal portion of the posterior wall and the septum. Exercise/rest Tc-99m-tetrofosmin myocardial imaging was a useful method for assessing myocardial perfusion abnormalities in patients with HCM. Reverse redistribution was detected very frequently on early and delayed images of exercise. We assumed that reverse redistribution may reflect a retention disorder of Tc-99m-tetrofosmin caused by some metabolic dysfunction of myocytes. (author)

  9. A Case of Habitual Neck Compression Induced Electroencephalogram Abnormalities: Differentiating from Epileptic Seizures Using a Tc-99m HMPAO SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hongyoon; Seo, Minseok; Lee, Hoyoung; Kim, Youngsoo; Yun, Changho; Kim, Sangeun; Park, Sungho [Seoul National Univ. Bundang Hospital, Seongnam (Korea, Republic of)

    2014-06-15

    Self-induced hypoxia has been reported particularly in adolescents, and it can result in neurological injury. Here, we present a case of electroencephalogram (EEG) abnormalities induced by habitual neck compression differentiated from epileptic seizures by Tc-99m HMPAO SPECT. A 19-year-old male was admitted for evaluation of recurrent generalized tonic-clonic seizures. No interictal EEG abnormality was detected; however, abnormal slow delta waves were found immediately after habitual right neck compression. To differentiate EEG abnormalities due to a hemodynamic deficit induced by habitual neck compression from an epileptic seizure, Tc-99m HMPAO SPECT was performed immediately after right carotid artery compression. Abnormal delta waves were triggered, and cerebral hypoperfusion in the right internal carotid artery territory was detected on Tc-99m HMPAO SPECT. The slow delta wave detected on the EEG resulted from the cerebral hypoperfusion because of the habitual neck compression.

  10. The role of Tc-99m sestamibi imaging in predicting clinical response to chemotherapy in lung cancer.

    Science.gov (United States)

    Dirlik, Aysegul; Burak, Zeynep; Goksel, Tuncay; Erinc, Ruya; Karakus, Haydar; Ozcan, Zehra; Veral, Ali; Ozhan, Mustafa

    2002-04-01

    Multidrug resistance (MDR) is a major problem in lung cancer. Tc-99m methoxyisobutyl isonitrile (MIBI) has been demonstrated to be a non-invasive marker to diagnose MDRI related P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) expression in various solid tumors. The aim of this study was to evaluate the relationship between the degree of Tc-99m MIBI uptake and its retention on delayed images and the response to chemotherapy in lung cancer. Twenty-three patients (1 woman and 22 men, age range 40-67 years) with lung cancer (9 small cell and 14 non-small cell) were examined with Tc-99m MIBI imaging before chemotherapy. After i.v. administration of 740 MBq Tc-99m MIBI, planar and SPECT imaging at 30 minutes and 2 hours was performed. Tumor to normal lung uptake ratio (T/N) and percent retention were measured. Response to chemotherapy was evaluated according to follow-up CT and grouped as complete responders (CR), partial responders (PR) and non-responders (NR). Clinical follow-up and CT evaluation revealed that 12 patients had partial remission, 4 patients had complete remission and 7 patients had no-remission after chemotherapy. Statistically, there was no significant correlation between early (30 min), delayed (2 hr) T/N ratios and percent retention of Tc-99m MIBI with chemotherapeutic response of the lung cancer among the three groups (p > 0.05). Results of the current study imply that Tc-99m MIBI uptake and the retention index may not correlate with chemotherapy response in lung cancer, so that the accuracy of this method needs to be verified in a larger series with additional investigation at the molecular level.

  11. Hodnoty akumulace Tc-99m-DMSA v ledvinách u dětí

    OpenAIRE

    HOMOLKOVÁ, Markéta

    2015-01-01

    Scintigraphic examination of the kidneys and urinary tract allow you to get a lot of information about the condition of the urinary tract. The main contribution of nuclear medicine today is the ability to do a precise quantitative assessment of the various functions of the kidneys and urinary tract. Currently for static scintigraphy and renal SPECT uses the nuclear medicine Tc-99m-dimercaptosuccinic acid or DMSA. For children is being used Tc-99m-DMSA activity of at least 20 MBq. Static scint...

  12. Potential use of isosorbide dinitrate As a new drug for tilt table test of young adult subject: A study of haemodynamic effects

    Directory of Open Access Journals (Sweden)

    Yoga Yuniadi

    2006-03-01

    Full Text Available Vasovagal syncope is a common health problem in young adult population. Tilt table test (TTT is the only method to diagnose vasovagal syncope. Since isoprenaline as a standard provocative drug of TTT is hard to be found in Indonesia, we study the haemodynamic effect of isosorbide dinitrate (ISDN which has similar venous pooling effect with isoprenaline. Seventeen young healthy adult subjects (age of 28.6 ± 4.7 year old, and 14 males underwent TTT using 400 μg ISDN spray sublingually as a provocative drug. The haemodynamic changes were observed during baseline and provocative phase. None of 17 subjects experienced of syncope. Although, the systolic, diastolic, and mean arterial blood pressure were significantly decreased and the heart rate significantly increased after ISDN administration, but the changes were not sufficient to cause syncopal event. In conclusion sublingual ISDN spray during TTT of young healthy adult subject changes haemodynamic measures but did not cause syncope. These results give a reasonable basic for ISDN usage as provocative drug of TTT. (Med J Indones 2006; 15:24-9Keywords: Syncope, vasovagal, tilt table test, nitrate

  13. Is Tc-99m Sulfur Colloid Scintigraphy Necessary in Chronic Immune Thrombocytopenic Purpura Before Splenectomy?

    Directory of Open Access Journals (Sweden)

    Ilçe HT et al.

    2011-05-01

    Full Text Available One of the most common reasons for elective splenectomy on adults ischronic immune thrombocytopenic purpura. It is characterized by thrombocyte destruction in spleen, so, management of splenectomy is the gold standard. However if there is remnant spleen tissue postoperatively it cause to going on thrombocytopenia. The principal reason of remnant spleen tissue is accessory spleen. So it is important to detect this tissue pre or postoperatively. Thirty years old, male patient underwent splenectomy four years ago because of chronic immunethrombocytopenic purpura. When thrombocytopenia recurrence occurredabdominal ultrasonography was performed and there was no abnormal sign. Then, Tc–99 m Sulfur Colloid Spleen Scintigraphy was performed and spleen tissue was detected in left hypochondriac region. Tc-99mSulfur Colloid Spleen Scintigraphy is one of the imaging method for accessory spleen. Especially if it is performed preoperatively the surgeon can be careful during the operation and at the same time detected accessory spleen was removed and recurrence can be prevented.

  14. Differential diagnosis of regional cerebral hyperfixation of TC-99m HMPAO on SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Shirazi, P.; Konopka, L.; Crayton, J.W. [Loyola Univ. Medical Center, Maywood, IL (United States)] [and others

    1994-05-01

    Accurate diagnostic evaluation of patients with neurologic and neuropsychiatric disease is important because early treatment may halt disease progression and prevent impairment or disability. Cerebral hyperfixation of HMPAO has been ascribed to luxury perfusion following ischemic infarction. The present study sought to identify other conditions that also display radiotracer hyperfixation in order to develop a differential diagnosis of this finding on SPECT imaging. Two hundred fifty (n=250) successive cerebral SPECT images were reviewed for evidence of HMPAO hyperfixation. Hyperfixation was defined as enhanced focal perfusion surrounded by a zone of diminished or normal cerebral perfusion. All patients were scanned after intravenous injection of 25 mCi Tc-99m HMPAO. Volume-rendered and oblique images were obtained with a Trionix triple-head SPECT system using ultra high resolution fan beam collimators. Thirteen (13/250; 5%) of the patients exhibited regions of HMPAO hyperfixation. CT or MRI abnormalities were detected in 6/13 cases. Clinical diagnoses in these patients included intractable psychosis, post-traumatic stress disorder, alcohol and narcotic dependence, major depression, acute closed-head trauma, hypothyroidism, as well as subacute ischemic infarction. A wide variety of conditions may be associated with cerebral hyperfixation of HMPAO. These conditions include neurologic and psychiatric diagnoses, and extend the consideration of hyperfixation beyond ischemic infarction. Consequently, a differential diagnosis of HMPAO hyperfixation may be broader than originally considered, and this may suggest a fundamental role for local cerebral hyperperfusion. Elucidation of the fundamental mechanism(s) for cerebral hyperperfusion requires further investigation.

  15. Evaluation of dynamic renal function by nuclear medicine using Tc-99m DTPA

    Energy Technology Data Exchange (ETDEWEB)

    Ishibashi, M.

    1987-01-01

    Dynamic renal function was nucleomedically evaluated using Tc-99m DTPA, and its value was assessed in various renal diseases. In addition to RI angiography, sequential image and renogram curve which were traditionally used as routine studies, Renal First Blood Flow (RFBF) by aortic blood flow exactly at the entrance of the renal artery, GFR (DTPA-GFR) by renal uptake and mean transit time (MTT) of the tracer by deconvolution analysis were measured. RFBF was useful to evaluate the stricture at the confluence of the renal artery and renal circulation, particularly cortical circulation. DTPA-GFR enabled the simple and rapid measurement of Total-GFR and Split-GFR. MTT was considered to be valuable in diagnosing obstructive nephropathy. In particular, RFBF was useful for assessment of renovascular hypertension. The measurement of the above-mentioned parameters made it possible to evaluate renal function objectively and quantitatively in addition to imaging and semiquantitative studies obtained by traditional routine examination. The major advantage of this procedure includes its possible performance along with routine renal function tests without any special preparation.

  16. Ophthalmoplegic migraine with reversible thalamic ischemia by Tc-99m ethylcysteinate dimer brain SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Ho; Shin, Dong Jin; Kang, Sung Soo [Gachon Medical School, Gil Medical Center, Inchon (Korea, Republic of)

    1999-07-01

    Two patients presented with ophthalmoplegic migraine (OM) underwent EEG, Brain-MRI, cerebral angiography, and Tc-99m ECD SPECT during an attack. Follow-up SPECT was performed after neurologic symptoms resolved. In both cases, SPECT during an attack of ophthalmoplegia and headache demonstrated a significantly decreased regional cerebral blood flow in the thalamus to the side of ophthalmoplegia, which was normalized on the follow-up SPECT during a symptom free recovery phase (Lesion to Non-lesion thalamic ratio=1.19 to 0.96 and 1.16 to 0.98, respectively). The other roentgenographic and laboratory findings were normal. These findings are suggestive the ischemia in the perforators of PCA results in third nerve palsy because the portion of oculomotor nerve behind the cavernous sinus derives its blood supply from small perforating branches of the basilar and PCA. Matched ictal hypoperfusion of the thalamus to the site of ophthalmoplegic migraine is suggestive of the ischemic neuropathy as an etiology of OM.

  17. Phantom Validation of Tc-99m Absolute Quantification in a SPECT/CT Commercial Device

    Directory of Open Access Journals (Sweden)

    Silvano Gnesin

    2016-01-01

    Full Text Available Aim. Similar to PET, absolute quantitative imaging is becoming available in commercial SPECT/CT devices. This study’s goal was to assess quantitative accuracy of activity recovery as a function of image reconstruction parameters and count statistics in a variety of phantoms. Materials and Methods. We performed quantitative Tc99m-SPECT/CT acquisitions (Siemens Symbia Intevo, Erlangen, Germany of a uniform cylindrical, NEMA/IEC, and an anthropomorphic abdominal phantom. Background activity concentrations tested ranged: 2–80 kBq/mL. SPECT acquisitions used 120 projections (20 s/projection. Reconstructions were performed with the proprietary iterative conjugate gradient algorithm. NEMA phantom reconstructions were obtained as a function of the iteration number (range: 4–48. Recovery coefficients, hot contrast, relative lung error (NEMA phantom, and image noise were assessed. Results. In all cases, absolute activity and activity concentration were measured within 10% of the expected value. Recovery coefficients and hot contrast in hot inserts did not vary appreciably with count statistics. RC converged at 16 iterations for insert size > 22 mm. Relative lung errors were comparable to PET levels indicating the efficient integration of attenuation and scatter corrections with adequate detector modeling. Conclusions. The tested device provided accurate activity recovery within 10% of correct values; these performances are comparable to current generation PET/CT systems.

  18. Gastric emptying time (GET) with Tc-99m-labeled semisolid meal in diabetic patients

    Energy Technology Data Exchange (ETDEWEB)

    Tada, Akira; Koizumi, Kiyoshi; Aburano, Tamio; Bunko, Hisashi; Tonami, Norihisa (Kanazawa Univ. (Japan). School of Medicine)

    1984-01-01

    Measurement of gastric emptying in diabetic gastroenteropathy is of interest because of the gastric atony that may produce signs and symptoms of visceral neuropathy. The purpose of this study is to present the result of GET measurements in diabetic patients. The correlation between GET and complications, fasting blood sugar (FBS), duration of disease, age, sex, and HbAlc was evaluated. Included in this study were 21 diabetic patients. Fourteen patients had diabetic complications such as peripheral neuropathy, autonomic neuropathy, nephropathy and retinopathy. Following an overnight fast, semisolid test meal mixed with 200 uCi of Tc-99m Sn-colloid was ingested by the patients. In nine normal volunteers, the GET range previously established by this method in our institution was from 47 to 78 minutes (mean 62.5 +- 7.7). In the patients with diabetic complication, particulary with triopathy, GET was significantly prolonged compared to those of normal subjects and diabetic patients without complication. On the contrary, four out of seven patients without complications, showed rapid emptying than normal subjects. This rapid emptying may reveal the early stage of pathophysiological change in diabetics. No correlation between GET and FBS, duration of disease, age, sex and HbAlc was seen. This test of radiolabeled semisolid meal was found to provide a convenient, safe and effective diagnostic tool to examine gastric emptying function in diabetic patients.

  19. Comparison of wall thickening and perfusion analysis in cardiomyopathy by gated Tc-99m MIBI

    Energy Technology Data Exchange (ETDEWEB)

    Cho, I.; Chun, K.; Won, K.; Lee, H.; Park, J.; Shin, D.; Kim, Y.; Shim, B [Yeungnam University Hospital, Taegu (Korea, Republic of)

    2002-07-01

    The objective of this study was to clarify the relationship between left ventriculr (LV) function, wall thickening (WT) and perfusion in cardiomyopathy. Twenty-six cases (15 males, 11 females: mean age, 58 y), consisting of 10 healthy control subjects, 10 patients with hypertrophic cardiomyopathy (HCM) and 6 patients with idiopathic dilated cardiomyopathy (DCM) was studied with gated Tc-99m MIBI SPECT. LV WT, LV perfusion and function (LV wall motion, LVEDV, LVESV and LVEF) by using gated SPECT quantification and CEqual software were analysed. In HCM and DCM group, mean WT was significantly decreased. (HCM: 15.2{+-}6.7%, DCM: 4.9%, control: 34.1{+-}4.9% (p<0.01). Adenosine stress test didn't show any reversible or fixed perfusion defects in all HCM patients, controls and five DCM patients except one patient (but, no coronary artery stenosis in coronary angiography). LVEF for HCM, DCM and control was 48.4{+-}13.2%, 28.7{+-}8.8%, 62.7{+-}9.5%, respectively (p<0.05)). LVEDV and LVESV didn't show a significant differences between HCM and control group, not DCM group. In HCM, WT was decreased as like DCM even though LV myocardial perfusion and function was reserved.

  20. The clinical usefulness of Tc-99m ECD brain SPECT in acute measles encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Seok Tae; Sohn, Myung Hee [School of Medicine, Chonbuk National Univ., Chonju (Korea, Republic of)

    2003-08-01

    Since the prognosis of measles encephalitis is poor, early diagnosis and proper management are very important to improve clinical outcomes. We compared Tc-99m ECD brain SPECT (SPECT) with MR imaging (MRI) for the detection of acute measles encephalitis. Eleven patients (M : F=4 : 7, age range 18 months-14 yrs) with acute measles encephalitis were enrolled in this studies. All of them underwent both MRI and SPECT. The results of SPECT were scored from 0 (normal) to 3 (most severe defect) according to perfusion state. We compared two image modalities for the detection of brain abnormality in acute measles encephalitis. Seven of 11 patients (63.6%) revealed high signal intensity in the white matter on T2WI of MRI, on the other hand all patients (100%) showed hypoperfusion on SPECT. Severe perfusion deficits above score 2 were located with decreasing frequencies in the frontal lobe (81.8%), temporal lobe (72.7%), occipital lobe (27.3%), basal ganglia (27.3%), and parietal lobe (9.1%). We conclude that SPECT is more useful than MRI for the detection of brain involvement in patients with acute measles encephalitis.

  1. Delayed reflow of an ischemic infarct after spontaneous thrombolysis studied by CBF tomography using SPECT and Tc-99m HMPAO

    DEFF Research Database (Denmark)

    Companioni, J M; Lassen, N A; Tfelt-Hansen, P

    1991-01-01

    A patient with a large ischemic infarct in the left middle cerebral artery territory was studied six times in the acute/subacute phase by cerebral blood flow (CBF) tomography using Tc-99m-HMPAO. The SPECT instrument used was a brain dedicated highly sensitive four-camera system (TOMOMATIC 232) th...

  2. A structure-activity-relationship (SAR) study of somatostatin receptor-binding peptides radiolabeled with Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Lister-James, J.; McBride, W.J.; Moyer, B.R. [Diatech, Inc, Londonderry, NH (United States)] [and others

    1994-05-01

    Somatostatin receptor (SSTR)-expressing tumors can be detected with high accuracy using In-111-[DTPA]octreotide. We sought a high-affinity SSTR-binding peptide labeled with the preferred radioisotope Tc-99m. We have prepared over 120 SSTR-binding peptides each containing a (N{sub 3}S or N{sub 2}S{sub 2}) chelator for Tc-99m in a SAR study in which peptide structure was systematically altered to optimize SSTR-binding affinity, in vivo rumor uptake and favorable biodistribution and pharmacokinetics. The HPLC-purified (>90% purity), chelator-containing peptides were characterized by FAB/ESMS and assayed in vitro for SSTR binding affinity by a competition assay (I-125 somatostatin-14 tracer and AR42J rat pancreatic tumor cell membranes). The oxo-rhenium complexes of the peptides were prepared by ligand exchange, characterized by FAB or ESMS and assayed for SSTR binding affinity as surrogates for the Tc-99m complexes. The Tc-99m complexes of peptides giving high-affinity oxo-rhenium complexes were also prepared by ligand exchange with specific activities of approx 300 mCi/mmol and examined in vivo for biodistribution and tumor uptake characteristics in CA20948 tumor-bearing rats.

  3. Improved diagnostic accuracy of lung perfusion imaging using Tc-99m MAA SPECT

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, J.K.; Golish, J.A.; Go, R.T.; Risius, B.; Graor, R.A.; MacIntyre, W.J.; Feiglin, D.H.

    1984-01-01

    The addition of emission tomography (SPECT) to pulmonary perfusion imaging should improve diagnostic accuracy by detecting perfusion defects otherwise masked by superimposition of normal lung activity and by reducing problems with interpretation of defects that result from overlying soft tissue or pleural effusions. In order to examine the contribution of SPECT in the scintigraphic evaluation for pulmonary embolus (PE), the authors have obtained both planar and SPECT studies in 94 cases of suspected PE. All studies employed 3-4 mCi of Tc-99m MAA and standard six-view planar image acquisition. SPECT raw data of 64 images were then acquired over a 360 degree transaxial rotation with subsequent computer reconstruction. Xe-133 ventilation studies were performed when clinically indicated and tolerated by the patient. For 19 studies angiographic (AN) correlation was obtained within 24 hours. In 16/19 planar and SPECT both gave a high probability of PE but SPECT gave better segmental localization and showed better agreement with the number of defects seen at AN. In 3 indeterminate planar scans, 2 were low probability with SPECT and had negative AN. The third, a patient with Wegener's vasculitis, remained indeterminate with SPECT and had negative AN. Five patients with PE had repeat planar/SPECT/AN studies to evaluate response to treatment. SPECT correlated better with AN findings in each case. The authors conclude that SPECT perfusion imaging provides better anatomic accuracy for defects representing PE and is the non-invasive technique of choice for documenting response to therapy.

  4. Quantitative Tc-99m myocardial perfusion SPECT with 180[degree] acquisition

    Energy Technology Data Exchange (ETDEWEB)

    Ye, J.

    1992-01-01

    Myocardial perfusion single photon emission computed tomography (SPECT) images using 180[degrees] acquisition are degraded by the effects of scatter, nonuniform attenuation and system geometric resolution variation with source depth. Using a 180[degrees] scan orbit which is closer to the heart may provide higher image resolution, signal-to-noise ratio and defect-to-normal contrast than using a 360[degrees] orbit, however, significant object shape distortion has been observed in the 180[degrees] reconstructed images. A method has been developed that combines filtered back-projection (FBP) with iterative attenuation and three-dimensional (3-D) resolution compensation for Tc-99m myocardial perfusion imaging, data. The non-uniform attenuation coefficient distribution is obtained by a quick transmission scan using a flood source and segmentation of the reconstructed transmission image to define areas of significantly different attenuation. A priori attenuation coefficients are assigned to the areas to form the attenuation distribution map. The 3-D correction is accomplished by including both the non-uniform attenuation and depth-dependent resolution variation in the reprojection procedure of an iterative correction algorithm. The method was evaluated with both simulated and experimental data using clinical protocols with a cardiac phantom. A significant improvement in image resolution was observed with line source images was reduced from approximately 10 mm to 7.l5 mm after 7 iterations of the 3-D correction. The contrast of two perfusion defects to the surrounding normally perfused regions was significantly improved with the correction. Significant improvement in uniformity at different positions in the 100% perfused areas in the myocardium was also observed. The normalized root squared error (NRSE) of one transaxial image from the original source distribution in the simulation study was reduced from 0.8 to 0.2 after 5 iterations of the 3-D correction.

  5. Tc-99m-sestamibi scintigraphy in gaucher disease, type 1

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chan H.; Pai, Moon S.; Ha, Man J.; Yoon, S. N.; Kim, S.; Whang, K. H.; Kim, Hyun J. [College of Medicine, Ajou Univ., Suwon (Korea, Republic of)

    1999-07-01

    Gaucher disease is an autosomal recessive disorder characterized by lysosomal glycolipid storage in reticuloendothelial cells due to the deficiency of lysosomal enzyme, acid-glucosidase. Type 1 is one of the three subtypes of Gaucher disease and is manifested by a chronic and progressive involvement of the spleen, liver, bone marrow and other visceral organs. This study was done to see imaging feasibility of bone marrow involvement of Gaucher cells using sestamibi. Five patients with Gaucher disease, type I (M:F=4:1, age range: 9-25) underwent a simultaneous anterior and posterior whole body scan as well as spot views of the lower extremities as needed in 10-20 min following the IV administration of 0.2 mCi/kg of Tc-99m-sestamibi. Control group consisted of 10 patients with osteosarcoma, simple bone cyst, nonossifying fibroma, osteoid osteoma, exostosis and neuroblastoma ( M: F=9:1, age range: 2-20, mean : 12.1) and sestamibi images of the group were obtained as in Gaucher cases. For in vitro evaluation, Gaucher cells were isolated from the splenectomy specimen. The cells were incubated in media containing sestamibi for 10, 29, 30 min. After washing the cells twice with saline, cell labeling was checked by external counting. Control group depicted no appreciable sestamibi uptake in the lower extremities while 5 patients with Gaucher disease, type I revealed variable degrees of sestamibi uptake. It was difficult to assess vertebral activities due to hepatosplenomegaly. Ioslated Gaucher cells took up sestamibi supported by an increasing external counting in proportion to incubation time. There was sestamibi uptake in the lower extremities involved by Gaucher disease, type I, which was distinctly different from the control group. Also in vitro study revealed sestamibi uptake in Gaucher cells. On the basis of these results, we believe, it may be possible to evaluate enzyme replacement therapy in Gaucher disease, type I, utilizing sestamibi scintiscan.

  6. Comparison of occupational radiation exposure from myocardial perfusion imaging with Rb-82 PET and Tc-99m SPECT.

    Science.gov (United States)

    Tout, Deborah; Davidson, Gillian; Hurley, Caroline; Bartley, Michelle; Arumugam, Parthiban; Bradley, Andy

    2014-10-01

    Rubidium-82 (Rb-82) PET myocardial perfusion imaging (MPI) has superior diagnostic accuracy, at least similar prognostic value, and lower patient radiation exposure when compared with technetium-99m single-photon emission computed tomography (Tc-99m SPECT) MPI. The aim of this study was to compare occupational radiation exposure from the two modalities and show that improvements for the patient do not come at a cost to staff. Electronic personal dosimeters were worn by staff involved in the administration and imaging of routine clinical Tc-99m SPECT and Rb-82 PET MPI, and during tracer production and QC. To estimate dose to the staff in the event of a medical emergency, a survey meter was placed in close contact with the patient during Rb-82 infusion and imaging, and immediately after administration for Tc-99m SPECT. Mean (SD) whole-body effective dose to staff during a single MPI procedure was 0.4 (0.4) μSv for Rb-82 PET (1110 MBq) and 3.3 (1.7) μSv for Tc-99m SPECT (350 MBq). Staff effective dose during tracer production and QC was low (<0.2 μSv/patient) and comparable between tracers. An additional effective dose was measured at close contact to the patient during, and immediately after, tracer administration, although this will not pose a significant radiation risk to staff with either technique as long as this is not routine practice. There is a significant reduction in effective dose during Rb-82 PET when compared with Tc-99m SPECT MPI because of the short half-life of Rb-82 and reduced patient contact.

  7. Case with stenosis of internal carotid artery detected as a region of decreased blood flow by Tc-99m HMPAO cerebral blood flow scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Hayashida, K.; Nishimura, T.; Uehara, T.; Imakita, S.; Yokota, I.; Ogura, H.; Oka, H.; Hayashi, M.; Kikuchi, H.

    1987-04-01

    Tc-99m hexamethylpropyleneamine oxime (= HMPAO) is expected to be an excellent agent as blood flow tracer of brain because it passes through blood brain barrier and is retained in brain parenchyma for several hours. Tc-99m HMPAO scintigraphy was applied to a patient complaining of transient ischemic attack without neurological findings. Left hemispheric hypoperfusion was detected by Tc-99m HMPAO cerebral blood flow scintigraphy. Although it was normal in CT and MRI, it was proved to be a 99 % stenosis of left internal carotid artery by digital subtraction angiography. Tc-99m HMPAO cerebral blood flow scintigraphy is useful for detecting abnormality of cerebral blood flow.

  8. Labeling proteins with Tc-99m via hydrazinonicotinamide (HYNIC): optimization of the conjugation reaction

    Energy Technology Data Exchange (ETDEWEB)

    Rennen, Huub J.J.M. E-mail: H.Rennen@nugen.azn.nl; Boerman, Otto C.; Koenders, Emile B.; Oyen, Wim J.G.; Corstens, Frans H.M

    2000-06-01

    At present there is considerable interest in labeling peptides with Tc-99m for the development of target specific radiopharmaceuticals for imaging purposes. In the present study the conjugation of the bifunctional coupling agent succinimidyl-hydrazinonicotinamide (S-HYNIC) was studied and optimized in a series of peptides [molecular weight (MW) 6.5-14.3 kDa]. Aprotinin (MW 6.5 kDa), cytochrome C (MW 12.4 kDa), {alpha}-lactalbumin (MW 14.2 kDa), and lysozyme (MW 14.3 kDa) were conjugated with S- via the {epsilon} amino groups of their lysine residues. The effects of molar conjugation ratio, reaction temperature, pH, and protein concentration were studied. Reaction products were analyzed both with respect to the HYNIC-substitution ratio (spectrophotometrically) as well as to the labeling efficiency silica gel-instant thin layer chromatography (SG-ITLC) and molecular size fast performance liquid chromatography (FPLC). The effects of conjugation on biological activity were studied in three proteins binding to receptors on leukocytes: interleukin-8 (MW 8.5 kDa), interleukin-1{alpha} (MW 17 kDa), and interleukin-1 receptor antagonist (MW 17 kDa). The labeling efficiency of aprotinin, cytochrome c, {alpha}-lactalbumin, and lysozyme conjugated under optimal conjugation conditions exceeded 90%. Specific activities obtained were up to 7.5 MBq/{mu}g. Conjugation was most efficient at 0 deg. C (as compared to 20 and 40 deg. C), at pH 8.2 (as compared to 6.0, 7.2, and 9.5), and at protein concentrations {>=} 2.5 mg/mL. In general, efficiency increased with increasing molar conjugation ratio (protein-HYNIC-ratio 1:3 < 1:6 < 1:15 < 1:30). For the receptor binding proteins, biological activity was preserved only under the mildest conjugation conditions. For each of these proteins an inverse relation between labeling efficiency and receptor binding capacity was found. Labeling proteins with {sup 99m}Tc using S-HYNIC is easy, rapid, and efficient, and preparations with high specific

  9. Estimation of hepatic functional reserve by asialoglycoprotein receptor-binding, radiolabeled synthetic ligand 'Tc-99m-galactosyl-neoglycoalbumin'. Preclinical and clinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, Masatoshi; Todo, Akio; Ikekubo, Katsuji

    1987-11-01

    Tc-99m-Galactosyl-Neoglycoalbumin (Tc-99m-NGA) is a receptor binding radiolabeled ligand, which binds to the asialoglycoprotein receptor of the plasma membrane of hepatocytes. NGA was prepared by covalently coupling D-galactose to normal human albumin. NGA was labeled with technetium-99m according to the electrolytic method by Benjamin, which produced Tc-99m-NGA with labeling yield in excess of 95%. Tc-99m-NGA was proved to be stable for at least 4 hours as determined by high performance liquid chromatography. Biodistribution studies of Tc-99m-NGA in normal rats demonstrated that liver is a sole target organ of Tc-99m-NGA. The lack of hepatic uptake of Tc-99m-NGA in healthy chicken corresponded to the lack of the asialoglycoprotein receptors in avian species. Tc-99m-NGA study in a normal volunteer showed apparently different images from those of Tc-99m-pyridoxyl-5-methyltryptophan (PMT) or Tc-99m phytate, suggesting that Tc-99m-NGA is a novel liver imaging radiopharmaceutical. The estimation of the time activity curves in the liver corresponded to the hepatic functional reserves which were evaluated by existing method in 9 clinical cases (2: Normal volunteers, 1: Chronic Active Hepatitis, 1: Liver Cirrhosis (Child A), 2: Liver Cirrhosis (Child B), 3: Liver Cirrhosis (Child C)). The NGA is useful as an imaging agent as well as in the estimation of the hepatic functional reserve, as the dynamic curves of the liver correlates to the asialoglycoprotein receptor concentration.

  10. Accumulation of Tc99m-DMSA-3 in the spleen in a case of multiple myeloma with associated amyloidosis

    Directory of Open Access Journals (Sweden)

    Barai Sukanta

    2005-01-01

    Full Text Available We describe a case of a 58-year-old male with longstanding hypertension and Type 2 diabetes mellitus who developed sudden onset renal impairment. The first clue to the possible presence of amyloidosis in this case was provided by the radionuclide renal cortical scan performed with trivalent dimercapto succinic acid (Tc99m-DMSA-3, which revealed intense tracer uptake in the spleen suggesting amyloid deposit. Further workup to ascertain the cause of amyloidosis led to the diagnosis of multiple myeloma. We conclude that in cases of extra-renal or splenic accumulation of Tc99m-DMSA-3, a diagnosis of amyloidosis should be considered, in an appropriate clinical setting.

  11. Bone healing in rabbits after compression osteosynthesis, studied by Tc-99m(Sn)polyphosphate scintimetry and autoradiography

    Energy Technology Data Exchange (ETDEWEB)

    Greiff, J.

    1981-08-01

    The purpose of the present study was to determine the scintimetric time course (STC) for Tc-99m(Sn) polyphosphate in rabbit tibias after various osteosynthetic procedures, and to correlate the findings with those from serial radiographs and with autoradiographic and histologic evaluation of the bone. The STC was similar for all treatment groups, with a peak value within the second week after surgery. Significantly different levels of the STC were found after subperiosteal exploration, plate insertion, osteotomy and compression plating, or osteotomy and medullary nailing. The radiological, autoradiographic, and histological findings revealed that Tc-99m scintimetry monitors callus formation. The STC thus appears to be a valuable tool for the quantitative study of bone healing.

  12. Infarction of renal transplant with extrarenal excretion of Tc-99m MAG{sub 3} demonstrated by renal scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Seok Tae; Kim, Min Woo; Sohn, Myung Hee [Chonbok National University Medical School, Chonju (Korea, Republic of)

    2003-06-01

    A 38-year-old woman with end stage renal disease received a living related donor-renal transplant to the right iliac fossa. She developed anuria a week later. Tc-99m MAG{sub 3} renal scintigraphy demonstrated no perfusion, uptake, or excretion of the radioactive tracer from the renal transplant. The expected area of the renal allograft appeared as a photopenic area with increased rim activity. The gallbladder and bowel activities were observed on delayed images at 24 hours. There was no blood flow within the renal artery on renal doppler examination. This case shows total absence of perfusion and function in the infarcted renal transplant with extrarenal excretion of Tc-99m MAG{sub 3} caused by acute renal artery thrombosis.

  13. Gamma camera energy windows for Tc-99m bone scintigraphy: effect of asymmetry on contrast resolution. Work in progress

    Energy Technology Data Exchange (ETDEWEB)

    Collier, B.D.; Palmer, D.W.; Knobel, J.; Isitman, A.T.; Hellman, R.S.; Zielonka, J.S.

    1984-05-01

    By raising the lower threshold of the Tc-99m energy window, rejection of scattered photons can be made more efficient. Unfortunately, with most gamma cameras significant nonuniformities are produced when the window is changed to an asymmetric setting. Recently introduced designs with gain stabilization of the photomultiplier tubes and improved energy correction maintain field uniformity even for an asymmetric window. To assess the impact of an asymmetric energy window on clinical images, 33 Tc-99m-MDP scintigrams of the lumbar spine were taken with symmetrical (126-154 keV) and asymmetric windows (135-154 keV). Bone:soft tissue ratios improved with the asymmetric window, and the resulting images were preferred by the physicians.

  14. Fibrous dysplasia associated with primary hyperparathyroidism absent of McCune-albright syndrome: Tc-99m MDP findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Jang; Seok, Ju Won; Kim, In Ju; Kim, Yong Ki; Kim, Dong Soo [Pusan National University College of Medicine, Pusan (Korea, Republic of)

    2003-04-01

    Fibrous dysplasia is a chronic disorder of the skeleton that causes expansion of one or more bones due to abnormal development of the fibrous, or connective tissue within the bone. The abnormality will cause uneven growth, brittleness and deformity in affected bones. Some patients have only one bone affected, whereas other patients have numerous bones affected. While any bone can be affected by fibrous dysplasia, the most common sites of the disease are the femur, tibia, ribs, skull, facial bones, humerus, and pelvis. In conclusion, Tc-99m MDP bone scan as well as Tc-99m MIBI scan may be useful for the detection of fibrous dysplasia. Also, factors responsible for the uptake of MIBI by fibrous dysplasia will need to be studied further.

  15. Ga-67 Citrate and Tc-99m MDP Uptake in the Lung and Stomach Associated with Hypercalcemia

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Yim, Chang Yeol [Chonbuk National University Medical School and Hospital, Jeonju (Korea, Republic of)

    2009-08-15

    Ga-67 scintigraphy demonstrated increased uptake in the lungs and stomach in a 26-year-old man with hypercalcemia. A primitive neuroectodermal tumor was confirmed by bone marrow examination. Tc-99m MDP uptake in the same locations as Ga-67 revealed by bone scintigraphy was consistent with metastatic calcification. Although the mechanism of Ga-67 uptake in metastatic calcification is not understood, the presence of an inflammatory process is suggested.

  16. Scintigraphic detection of occult hemorrhage using RBCs labeled in vitro with technetium Tc 99m sodium pertechnetate

    Energy Technology Data Exchange (ETDEWEB)

    Bunker, S.R.; Kolina, J.S.; Kaplan, K.A.; McAuley, R.J.; Lull, R.J.

    1983-05-01

    Scintigraphy with RBCs labeled with technetium Tc 99m sodium pertechnetate effectively located the source of hemorrhage in a patient receiving long-term anticoagulant therapy. (The patient was initially seen with a large hematoma on the flank.) More important, the procedure was used to monitor activity in this otherwise-occult bleeding site. Scintigraphic studies may be useful in the management of these difficult clinical problems.

  17. Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong-il; Ha, Seunggyun [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University Bundang Hospital, Department of Nuclear Medicine, Seongnam-si, Gyeonggi-do (Korea, Republic of); So, Young [Konkuk University School of Medicine, Department of Nuclear Medicine, Chungju (Korea, Republic of); Lee, Won Woo [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University, Institute of Radiation Medicine, Medical Research Center, Seoul (Korea, Republic of); Seoul National University Bundang Hospital, Department of Nuclear Medicine, Seongnam-si, Gyeonggi-do (Korea, Republic of); Byun, Seok-Soo [Seoul National University College of Medicine, Department of Urology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kim, Sang Eun [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University, Institute of Radiation Medicine, Medical Research Center, Seoul (Korea, Republic of)

    2014-02-15

    We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. The revised equation for improved GFR was GFR(mL/min) = (%renal uptake x 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m{sup 2}) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m{sup 2}; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m{sup 2}) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. (orig.)

  18. Quantitative Evaluation of Therapeutic Efficacy of Endovenous Laser Treatment for Distal Varicose Veins by Tc-99m RBC Venography

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Young; Song, Ki Hoon; Sim, Seung Joo; Kim, Ki Ho [College of Medicine, Univ. of Donga, Busan (Korea, Republic of)

    2003-07-01

    Endovenous laser treatment (EVLT) has been shown to be effective for elimination of greater saphenous (GSV) incompetence. While the result of GSV closure has been studied in detail, the effects in distal GSV and its tributaries following EVLT are still not completely understood. In addition, the optimal time for treatment of remaining varicose veins is not established. We evaluated the clinical and radiological changes of distal varicose veins after EVLT and determined the optimal time for additional treatment of distal varicose veins following EVLT by Tc-99m RBC. Forty GSV (30 patients) were treated with 940 nm or 810 nm diode laser at usual energy setting. Clinical and Duplex evaluation were performed at I week, and at various monthly intervals (2-6 months) following the initial treatment. Tc-99m venography was performed as usual protocol at I month and at every 3 months after EVLT. The distal varicose veins were quantified by determining the ratio of mean counts per pixel in the target and background areas and then comparing the pre-EVLT and post-EVLT values. Thirty-eight (95.0%) GSV were closed following EVLT and remained closed at 1-21 months follow-up examination. The reduction rate of distal varicose veins measured by Tc-99m venography was 22.8% at l month, 42.7% at 3 months, 61.5% at 6 months, and 72.4% at 9 months after EVLT. Fifteen legs (37.5%) required additional phlebectomy at 1 to 3 months after EVLT, while the others (62.5%) showed spontaneous regression of distal veins from one month during follow-up period. Therapeutic efficacy of EVLT for distal varicose vein can be well-evaluated quantitatively by Tc-99m RBC venography. Theses results suggest that after EVLT for GSV, the 'wait' policy would be necessary, rather than the 'wasting' of distal veins concurrently with EVLT.

  19. Tc-99m HMPAO white blood cell scintigraphy of an enterovesical fistula complicating Crohn's disease

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Ho; Hyun, In Young; Kim, Young Soo; Choe, Won Sick; Woo, Ze Hong [Chonnam Univ. Hospital, Kwangju (Korea, Republic of)

    2000-02-01

    Computed tomography (CT) seems to be the best imaging modality to diagnose an enterovesical fistula, but is not always able to demonstrate enterovesical fistula itself. In this case report, we present Tc-99m HMPAO white blood cell (WBC) scintigraphic findings of an enterovesical fistula complicating Crohn's disease. A 22 year-old male presented with a one-month history of urinary symptoms such as dysuria, hematuria, and frequency. The patient had intermittent right lower quadrant pain, diarrhea and hematochezia. Enterovesical fistula was highly suggestive in pelvic CT which showed air density in the urinary bladder, but cystoscopy failed to find and opening of the fistula.Tc-99m HMPAO WBC scintigraphy for evaluation of inflammatory bowel disease incidentally demonstrated enterovesical fistular tract. Crohn's disease was later confirmed by histologic examination of the surgical specimen. In our patient, Tc-99m HMPAO WBC imaging was helpful in determining the location of the fistula as well as assessing the disease acivity and extent of the Crohn's disease.

  20. Clinical indications to the use of Tc-99m-EDDA/HYNIC-TOC to detect somatostatin receptor-positive neuroendocrine tumors

    NARCIS (Netherlands)

    Parisella, M. G.; Chianelli, M.; D'Alessandria, C.; Todino, V.; Mikolajczak, R.; Papini, E.; Dierckx, R. A.; Scopinaro, F.; Signore, A.

    The aim of this study was to define, retrospectively, the utility to perform Tc-99m-EDDA/HYNIC-Tyr3-octreotide (Tc-99m-EDDA/HYNIC-TOC) scan in patients with NET. We studied 50 consecutive patients affected by different types of NET and divided in two groups. Group 1: 34 patients with known lesions

  1. Clinical indications to the use of Tc-99m-EDDA/HYNIC-TOC to detect somatostatin receptor-positive neuroendocrine tumors

    NARCIS (Netherlands)

    Parisella, M. G.; Chianelli, M.; D'Alessandria, C.; Todino, V.; Mikolajczak, R.; Papini, E.; Dierckx, R. A.; Scopinaro, F.; Signore, A.

    2012-01-01

    The aim of this study was to define, retrospectively, the utility to perform Tc-99m-EDDA/HYNIC-Tyr3-octreotide (Tc-99m-EDDA/HYNIC-TOC) scan in patients with NET. We studied 50 consecutive patients affected by different types of NET and divided in two groups. Group 1: 34 patients with known lesions i

  2. Asymmetric uptake of Tc-99m HDP on temporomandibular joints may predict prognosis of temporomandibular joint disease

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Mi; Lee, Won Woo; Yun, PiI Young; Kim, Young Kyun; Kim, Sang Eun [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    There is no reliable predictor for therapeutic efficacy for temporomandibular joint (TMJ) disease. The aim of the present study was to evaluate the usefulness of Tc-99m HDP bone scan in the pre-therapeutic assessment of prognosis for TMJ disease. Between January 2005 and July 2007, 94 patients (M: F=18: 76; mean age, 33.4{+-}14.0 y) with TMJ disease who underwent pre-therapeutic bone scan were enrolled. Planar bone scan images were obtained at right and left lateral skull areas 3 hours post Tc-99m HDP injection (dose=1295 MBq). TMJ uptake of Tc-99m HDP was quantitated using 13X13 pixel-square region-of-interest over TMJ and parietal skull area as background. TMJ uptake ratio was calculated as; (TMJ background) / background. Asymmetric indices for involved TMJ uptake (Al{sub invovle}) were defined as; TMJ uptake ratio of involved/non-involved joint. Asymmetric indices for greater TMJ uptake regardless of disease involvement (AI{sub greater}) were defined as; TMJ uptake ratio of greater/smaller TMJ uptake. Splint therapy was applied to all patients with mean duration of 7 months (range; 3-34 months). Therapeutic efficacy was dichotomised as improved or non-improved in consideration of mandibular movement, TMJ noise, pain, and tenderness. Seventy-six patients experienced improvement, whereas 18 patients non-improvement. There was no significant difference between improved versus non-improved patients regarding TMJ uptake ratio of involved joint (2.92{+-}0.82 vs. 2.91{+-}0.66), and AI{sub invovle} (1.16{+-}0.22 vs. 1.10{+-}0.12) (p>0.05, t-test). However, AI{sub greater} was significantly higher in improved patients than non-improved patients (1.20{+-}0.19 vs. 1.13{+-}0.09, p<0.05, t-test). Regardless of disease involvement of TMJ disease, asymmetricities of Tc-99m HDP uptake were more frequently found in improved group after splint therapy. Tc-99m HDP bone scan can predict the efficacy of splint therapy in TMJ disease.

  3. Evaluation of Bone or Soft Tissue Infection with Tc-99m Hmpao White Blood Cell Scintigraphy: Semiquantitative Method

    Directory of Open Access Journals (Sweden)

    Funda Aydın

    2015-02-01

    Full Text Available Objective: Aim the aim of this study was to investigate semiquantitatively the diagnostic performance of Tc-99m hexamethypropylene amine oxime labeled white blood cell (Tc-99m HMPAO-WBC scintigraphy in patients with suspected bone or soft tissue infections. Methods: Material and Method twenty one patients who applied to Nuclear Medicine Departmant (for suspected prosthesis infection, diabetic foot, bone infection, graft infection were evaluated retrospectively. Tc-99m HMPAO WBC scintigraphy imaging were performed to all patients. Planar images were taken 1., 2., and 4. hours after injecting the labeled leukocytes. Evaluation of infection with Tc-99m HMPAO WBC scintigraphy was done semiquantitatively. Relative uptake was determined by setting the region of interest (ROI of lesion area on the anterior view. Rectangular ROI was set on the against limb (nonlesion. The ratio of the average pixel count in the lesion (L to that in the non-lesion (NL (L/NL ratio was calculated at 1., 2., and 4. hours images. Final diagnosis was based on histopathology, microbiologic assays, or clinical and imaging follow-up. Results: 0.55 and 1.55±0.74, 1.42±0.55, 1.40±0.55 in positive and control groups, respectively. Positive group revealed a statistically significant increase L/NL values in the data 3 hours images (p=0.002. However, no statistically significant was found between L/NL values in 3 hours imaging data in control group (p=0.223. All the data in the positive group found a statistically increased steadily. Furthermore, statistically significant difference was found between the positive and control group at 2., and 4. hours images (p=0.015, and p=0.006 .±0.43, 2.05±0.35, 1.90±SD values were found to be 1.74±Results of the 21 patients, 11 were found to have infection (positive group, whereas 10 had normal (control group pathologies on histopathology, microbiologic assays, or clinical and imaging follow-up. First, 2., and 4. hours L/NL (mean Conclusion

  4. Prognostic Value of Tc99m-Pertechnetate Thyroid Scintigraphy in Radioiodine Therapy in a Cohort of Chinese Graves’ Disease Patients: A Pilot Clinical Study

    Directory of Open Access Journals (Sweden)

    Haifeng Hou

    2015-01-01

    Full Text Available Objectives. This study is to assess the prognostic value of Tc99m-pertechnetate thyroid scintigraphy for predicting the outcomes of fixed low dose of radioiodine therapy (RIT in a cohort of Chinese Graves’ disease (GD patients. Materials and Methods. This is a retrospective study of GD patients who received RIT with a single dose of radioiodine (5 mCi. All the patients received Tc99m-pertechnetate thyroid scintigraphy prior to RIT. Thyroid mass, Tc99m-pertechnetate uptake, gender, age at diagnosis, duration of the disease, ophthalmopathy, and serum levels of FT4, FT3, TT4, and TT3 prior to RIT were analyzed as potential interference factors for outcomes of RIT. Results. One hundred and eighteen GD patients who completed RIT were followed up for 12 months. The outcomes (euthyroidism, hypothyroidism, and hyperthyroidism were found to be significantly associated with thyroid mass and Tc99m-pertechnetate uptake. Patients with thyroid mass ≤ 40.1 g or Tc99m-pertechnetate uptake ≤ 15.2% had higher treatment success. Conclusions. A fixed low dose of 5 mCi radioiodine seems to be practical and effective for the treatment of Chinese GD patients with thyroid mass ≤ 40.1 g and Tc99m-pertechnetate uptake ≤ 15.2%. This study demonstrates Tc99m-pertechnetate thyroid scintigraphy is an important prognostic factor for predicting the outcomes of RIT.

  5. Tc-99m-ECD SPECT as the measure for therapeutic response in patients with cobalamin deficiency

    Science.gov (United States)

    Tu, Min-Chien; Lo, Chung-Ping; Chen, Ching-Yuan

    2016-01-01

    Abstract Background: Cobalamin (Cbl) is an essential vitamin for human health. While an increasing body of evidence supports the negative impact of Cbl deficiency on cognition, the causality has yet to be determined, and the reported therapeutic responses after Cbl supplement therapy have been inconsistent. Besides, few reports have described neuroimaging characteristics associated with the therapeutic response. Methods: To describe and compare technetium-99m ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m-ECD SPECT) findings in 2 patients with Cbl deficiency with distinct therapeutic responses. Results: Case 1 scored 12/30 in the mini-mental state examination (MMSE) and 34/100 in the cognitive abilities screening instrument (CASI). Profound deficits in mental manipulation, drawing, short-term/long-term memory, and verbal fluency were noted. Case 2 scored 24/30 in the MMSE and 78/100 in the CASI, mainly due to impaired mental manipulation, abstract thinking, and borderline performance in short-term memory and verbal fluency. While both cases showed widespread hypoperfusion within bilateral frontotemporal regions and thalamus on Tc-99m-ECD SPECT, Case 2 demonstrated relatively preserved radio-uptake in the frontal regions, especially the anterior cingulate cortex (ACC) and prefrontal cortex (PFC), consistent with the better therapeutic response (Case 1: 12/30 to 11/30 in the MMSE; Case 2: 24/30 to 28/30 in the MMSE). Conclusion: Given that the ACC integrates the limbic system and frontosubcortical circuits and the PFC governs executive function, the extent and severity of hypofrontality may be responsible for the worse prognosis. Our Tc-99m-ECD SPECT observations revealed that the negative impact on cerebral metabolic tone is relevant to the severity of Cbl deficiency, and the functional integrity of the ACC and PFC is highly associated with the preservation of global cognitive function in our cases with Cbl deficiency. PMID:27684816

  6. Computer simulation and experimental investigation of Mo-99 yield in thick targets as a Tc-99m generator

    Science.gov (United States)

    Malykhina, T.; Torhovkin, O.

    2017-09-01

    The most important requirement for the production technology of radionuclides is to provide a high specific activity of the target nuclide as well as the full activity of the target. This problem can be solved by using a large volume of photonuclear targets, and then by the target nuclide radiochemical separation. Computer simulation and experimental study of the spatial distribution of the activity is carried out in this work for the molybdenum target. Optimal parameters of irradiation to achieve the maximum yield of isotopes Mo-99 (Tc-99m) from the molybdenum target have been found.

  7. Assessment of lung toxicity caused by bleomycin and amiodarone by Tc-99m HMPAO lung scintigraphy in rats.

    Science.gov (United States)

    Gumuser, G; Vural, K; Varol, T; Parlak, Y; Tuglu, I; Topal, G; Sayit, E

    2013-08-01

    The purpose of the study was to determine the lung toxicity caused by amiodarone (AD) and bleomycin (BLM) in rats, by means of Tc-99m HMPAO lung scintigraphy. Thirty albino rats were randomly divided into five groups. After AD or BLM was dissolved with isotonic saline (SF), a 0.5 ml solution was applied to the right bronchus via a catheter. Group 1 (n = 5 rats) received a single dose of AD, group 2 (n = 5) received two doses of AD, group 3 (n = 9) received BLM, group 4 (n = 3) received hydrochloric acid (HCl), and group 5 (n = 8) received SF. Rats in groups 1, 2, 3 and 5 were given 37 MBq Tc-99m HMPAO from the tail vein on days 7, 14, 21 and 28, and at 4 and 24 h in group 4. Static images of 10 min duration were obtained at 30 and 60 min by a double-headed gamma camera (Infinia, GE, Tirat Hacermel, Israel) on 256 × 256 matrix. Regular regions of interests were drawn over the right lung (RL), left lung (LL) and the liver (Li), and lung/liver (L/Li) ratios were calculated. After the scintigraphic imaging procedures were completed, rats were killed. Lung tissues were evaluated on a scale of (+) to (+++++) for edema, alveolar structural integrity and infiltration by inflammatory cells. Groups 2 and 3 showed statistically significant differences in RL/Li and LL/Li ratios, whereby RL/Li was higher than LL/Li (p  0.05). In histopathological examination, minimal damage or artifacts were observed in group 5. In group 4, almost all pathological findings were present in the right lung. Statistically significant (p lung tissues of the control rats that were given HCl. Increased RL/Li ratios and histopathological findings were consistent. Tc-99m HMPAO lung scan are found to be useful in the identification of patients with lung toxicity. The simplicity of the procedure and lower radiation exposure are the advantages of Tc-99m HMPAO lung scan.

  8. Vascular calcification of the lower extremities demonstrated by Tc-99m MDP bone scintigraphy in a patient with diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Seok Tae; Sohn, Myung Hee [Chonbuk National University Medical School, Chonju, l (Korea, Republic of)

    2001-06-01

    The femoral vessels are sometimes visualized on bone scintigraphy. This is almost always caused by calcification of the femoral artery associated with atherosclerotic changes of the arterial wall. Vascular calcification is frequently seen in the elderly and in diabetics. A 78 year old woman was admitted for non-insulin dependent diabetes mellitus. In this patient with diabetes mellitus, tibial arteries as well as femoral arteries were visualized onTc-99m MDP bone scintigraphy in contrast with visualization of femoral artery alone observed in the elderly.

  9. [Protein losing enteropathy (PLE) detected by Tc99m-labelled human serum albumin abdominal scintigraphy--case report].

    Science.gov (United States)

    Hubalewska-Hoła, Alicja; Sowa-Staszczak, Anna; Szczerbiński, Tomasz; Lis, Grzegorz; Huszno, Bohdan; Szybiński, Zbigniew

    2003-01-01

    Protein losing enteropathy (PLE) is a gastrointestinal disorder that is associated with excessive loss of plasma protein into the gut resulting from abnormal mucosal permeability. The disease is usually caused by inflammation. The loss of protein in PLE is a nonselective process affecting albumin, globulin and transferrin. Abdominal scintigraphy with human serum albumin marked by Tc99m seems to be an easy and sensitive method for diagnosing PLE. An 4-year-old girl was presented to an outside Pediatric Department due to hypoproteinemia and recurrent pneumonia which had caused several prior hospitalizations. The laboratory tests revealed hypoproteinemia, hypoalbuminemia, low level of IgG, sideropenia, and a decreased level of T lymphocytes. The loss of protein into the gut was confirmed by fecal clearance of alfa-1 antitrypsin. Only nonspecific inflammation was detected by biopsy of the small intestine. These clinical and laboratory findings, quickly decreasing IgG and albumin levels in spite of i.v. supplementation and the lack of proteinuria permitted PLE diagnosis. The abdominal scintigraphy was planned to assess and localise protein losing through GIT and for strategy of possible surgical treatment. Abdominal dynamic scintigraphy was performed immediately after the injection of 300 MBq Tc99m human albumin. 90 images were taken within 180 minutes. Delayed abdominal images were obtained 6 and 24 hours after the tracer injection. Anterior abdominal scintigraphy showed pathological activity of Tc99m-albumin in small bowel in the upper left segment of the abdomen in the 40th minute after injection. Extensive accumulation of albumin was seen in the 160th minute. Delayed images, after 3 and 6 hours, revealed translocation of the tracer into the lower right abdominal segment. The further passage and tracer concentration was detected in ascendant and transverse colon. Based on the laboratory tests and scintigraphic images the girl was suspected to have segmental

  10. A predominant pelvic gastrointestinal stromal tumor (GIST) mass observed on Tc-99m red blood cell gastrointestinal bleeding scintigraphy.

    Science.gov (United States)

    Sood, Ravi; Tee, Shang Ian

    2011-08-01

    A 51-year-old woman presented with recurrent bleeding per rectum. Her earlier endoscopies were negative. Tc-99m RBC GI bleeding scintigraphy was performed. It demonstrated an apparent hypervascular pelvic mass, and active small bowel bleeding. Based on scintigraphic finding of a predominant pelvic mass indicating tumor, CT of the abdomen and pelvis was performed for further gastrointestinal bleeding localization work up instead of an invasive angiography or endoscopy, which detected a small bowel tumor in the pelvis. A small bowel gastrointestinal stromal tumor was resected subsequently.

  11. Incidental detection of a pseudoaneurysm at an amputation stump in a Tc-99m HMPAO labeled leukocyte scan

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Jeong, Hwan Jeong; Lim, Seok Tae [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2007-08-15

    A 20-year-old man underwent a Tc-99m HMPAO labeled leukocyte scan for the evaluation of an infection at the stump of an AK amputation, which was conducted due to an open communicated fracture of the left lower leg. Blood-flow and blood-pool images demonstrated a pseudoaneurysm with a focus of intense activity medial to the stump, and centered within a large photopenic defect by surrounding hematoma. Delayed image obtained at 3 hours post-injection showed persistent intense and slight increased activity. Contrast angiography confirmed the presence of a pseudoaneurysm arising from a branch of the left superficial femoral artery.

  12. Vertebral uptake of Tc-99m macroaggregated albumin (MAA) with SPECT/CT occurring in superior vena cava obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Karls, Shawn; Hassoun, Hani; Derbekyan, Vilma [Dept. of Nuclear Madicine, Royal Victoria Hospital, Montreal (Canada)

    2016-09-15

    A 67-year-old male presented with dyspnea for which lung scintigraphy was ordered to rule out pulmonary embolus. Planar images demonstrated abnormal midline uptake of Tc-99m macroaggregated albumin, which SPECT/CT localized to several thoracic vertebrae. Thoracic vertebral uptake on perfusion lung scintigraphy was previously described on planar imaging. Radionuclide venography and contrast-enhanced CT subsequently demonstrated superior vena cava (SVC) obstruction with collateralization through the azygous/hemiazygous system and vertebral venous plexus. SPECT/CT differentiated residual esophageal/tracheal ventilation activity, a clinically insignificant finding, from vertebral uptake indicative of SVC obstruction, a potentially life-threatening condition.

  13. Biologic gastric emptying time in diabetic patients, using Tc-99m-labeled resin-oatmeal with and without metoclopramide

    Energy Technology Data Exchange (ETDEWEB)

    Domstad, P.A.; Kim, E.E.; Coupal, J.J.; Beihn, R.; Yonts, S.; Choy, Y.C.; Mandelstam, P.; DeLand, F.H.

    1980-11-01

    Biologic gastric emptying time (BGET) was measured in 24 patients with severe diabetes mellitus complicated by vascular damage and peripheral or sensory neuropathy. This population had a BGET of 192 +- 32.9 min (mean +- s.e.m. normal 40 to 85 min). Patients with diabetic gastroenteropathy had prolongation of BGET to 295 +- 45 (p < 0.05). Metoclopramide significantly shortened BGET in this subgroup to 101 +- 40 min, with return to normal values in eight of the 12 patients given the drug. The Tc-99m-labeled resin-oatmeal test meal used as described in this study provides a reliable measure of BGET and of the response to metoclopramide.

  14. A Case of Enterocutaneous Fistula Diagnosed with Tc-99m DTPA Fistulography Using Hybrid SPECT/CT.

    Science.gov (United States)

    Choi, Hongyoon; Paeng, Jin Chul; Chun, In Kook; Baik, Kyung Don; Kang, Keon Wook; Chung, June-Key; Lee, Dong Soo

    2012-06-01

    Enterocutaneous fistula (ECF) is a communication between the bowel lumen and the skin, which especially occurs post-operatively and is associated with significant morbidity and mortality. Correct diagnosis and anatomical information of ECF are crucial for a patient's management. Here, we present a case of ECF clearly diagnosed by hybrid single-photon emission computed tomography/computed tomography (SPECT/CT). A 61-year-old man was admitted to our hospital with persistent pus discharge from a surgical wound of previous cystectomy and ileal conduit formation. Initially, he was assessed with fistulography, and ECF was suspected by intraluminal contrast media. As clinical symptom and signs were not definitely matched with ECF, Tc-99m diethylene triamine pentaacetic acid (DTPA) SPECT/CT was performed for the evaluation of fistular tract as an alternative method. On the SPECT/CT after injection of Tc-99m DTPA to the putative fistular opening, fistular as well as intraluminal radioactivity was clearly visualized. SPECT/CT is a sensitive and safe diagnostic imaging tool for ECF.

  15. Comparison of diagnostic performance between interictal F-18-FDG PET and ictal Tc-99m-HMPAO SPECT in occipital lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seok Ki; Lee, Dong Soo; Yeo, Jeong Seok; Lee, Sang Kun; Kim, Joo Yong; Jeong, Jae Min; Chung, June Key; Lee, Myung Chul [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    1999-02-01

    Interictal F-18-fluorodeoxyglucose (FDG) PET and ictal Tc-99m-HMPAO SPECT are found to be useful in localizing epileptogenic zones in neocortical lateral temporal or frontal lobe epilepsy. We investigated whether interictal F-18-FDG PET or ictal Tc-99m-HMPAO SPECT was useful to find epileptogenic zones in occipital lobe epilepsy (OLE). We reviewed patterns of hypometabolism in interictal F-18 FDG PET and of hyperfusion in ictal Tc-99m-HMPAO SPECT in 17 OLE patients (mean age=27{+-}6.8 year, M : F=10:7, injection time =30{+-}17 sec). OLE was diagnosed based on invasive electroencephalography (EEG) study, surgery and post-surgical outcome (Engel class I in all for average 14 months). Epileptogenic zones were correctly localized in 9 (60%) out of 15 patients by interictal F-18-FDG PET. Epiletogenic hemispheres were correctly lateralized in 14 patients (93%) . By ictal Tc-99m-HMPAO SPECT, epileptogenic hemispheres were correctly lateralized in 13 patients (76%), but localization was possible only in 3 patients (18%). Among patients who showed no abnormality with MR imaging and no correct localization with ictal Tc-99m-HMPAO SPECT, interictal F-18-FDG PET was helpful in 2 patients. Ictal Tc-99m-HMPAO SPECT was helpful in lateralization but not in localization in OLE. Interictal F-18-FDG PET was helpful for localization of epileptogenic zones even in patients with ambiguous MR of ictal SPECT findings.

  16. Relation between Tc-99m-PYP and Tl-201 scintigraphic findings and left ventricular function in acute myocardial infarction with early reperfusion

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Takao; Fukuzaki, Hisashi; Igarashi, Yuuichirou; Minamiji, Katsumi; Takarada, Akira; Imai, Naoaki; Fujino, Motohiro; Kurogane, Hiroyuki; Yoshida, Yutaka.

    1988-07-01

    The purpose of this study was to examine the significance of Tc-99m PYP uptake in the evaluation of myocardial salvage and reperfusion injury during early reperfusion in acute myocardial infarction. The subjects were 54 patients with initial myocardial infarction attributable to left anterior descending branch lesion in whom early reperfusion was attained by spontaneous recanalization (SR), intracoronary thrombolysis (ICT), and percutaneous transluminal angioplasty (PTCA). The radionuclide imaging appearances of the myocardium fell into four categories : I) small Tl-201 defect and faint Tc-99m PYP uptake ; II) small Tl-201 defect and intense Tc-99m PYP uptake ; III) large Tl-201 defect and faint Tc-99m PYP uptake ; and IV) large Tl-201 defect and intense Tc-99m PYP uptake. The incidences of I and II were higher in the group of SR patients than the group of ICT and PTCA patients. Features of left ventricular ejection fraction (LVEF) from the acute through the chronic stages were as follows : Category I - favorable LVEF through the stages ; Category II - improvement at chronic stage ; Category III - no consistent tendency for LVEF ; and Category IV - aggravation at chronic stage. In cases of early recanalization of acute myocardial infarction, Tc-99m PYP images combined with Tl-201 images may provide useful information on changes of cardiac function and salvage of the ischemic myocardium. (Namekawa, K.).

  17. L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake

    Directory of Open Access Journals (Sweden)

    Yakup Yürekli

    2011-04-01

    Full Text Available Objective: In this study, we aimed to investigate the cytoprotective effect of L-carnitine against cisplatin-induced nephrotoxicity and to compare its efficacy with that of amifostin by quantitative renal Tc 99m DMSA uptake. Material and Methods: Male Wistar rats were randomly divided into six groups of six animals each. 1 Control (saline; 5 ml/kg intraperitoneally; 2 L-carnitine (CAR; 300 mg/kg intraperitoneally; 3 Amifostine (AMI; 200 mg /kg intraperitoneally; 4 Cisplatin (CIS;7 mg/kg intraperitoneally; 5 Cisplatin plus L-carnitine (CIS + CAR; 6 Cisplatin plus amifostine (CIS + AMI. L-carnitine and amifostine were injected 30 minutes before cisplatin in Group 5 and 6. Tc 99m DMSA, 7.4 MBq/0.2 ml, was injected through the tail vein 72 hours after the drug administration. Rats were killed and kidneys removed by dissection 2 hours after the injection of the radiopharmaceutical. The percentage of the injected dose per gram of kidney tissue (%ID/g was calculated. Renal function was monitored by measuring BUN and plasma levels of creatinine. Lipid peroxidation and glutathione content were determined by measuring malondialdehyde (MDA and reduced glutathione (GSH in kidney tissue homogenates. Results: Tc 99m DMSA uptake per gram tissue of the kidney as %ID/g was 29.54±4.72, 29.86 ± 7.47 and 26.37 ± 4.54 in the control, CAR and AMI groups respectively. %ID/g was the lowest of all the groups, 11.60±3.59 (p<0.01, in the cisplatin group. Carnitine or amifostine administration 30 minutes before cisplatin injection resulted a significant increase in %ID/g, 21.28±7.73 and 18.97±3.24 respectively, compared to those of cisplatin-treated rats (p<0.002. A marked increase in plasma BUN and creatinine indicating nephrotoxicity and acute renal failure was observed in the cisplatin-treated group. MDA and GSH levels were concordant with cisplatin-induced oxidative stress in the kidney tissue. Conclusion: The results showed that L-carnitine significantly

  18. Benign incidental findings of osteopoikilosis on Tc-99m MDP bone SPECT/CT: A case report and literature review.

    Science.gov (United States)

    Tsai, Szu-Ying; Wang, Shan-Ying; Shiau, Yu-Chien; Wu, Yen-Wen

    2016-06-01

    Osteopoikilosis is a benign but rare condition characterized by bone islands throughout the osseous tissue, which could be easily confused with bone metastasis. We present a case of a 37-year-old man presented to orthopedic outpatient clinic with right hip pain for 2 weeks. There were multiple, small punctate lesions scattered throughout the skeleton on radiograph. Subsequent Tc-99m methylene diphosphonate (MDP) bone scan with pelvic single-photon emission computed tomography (SPECT)/computed tomography (CT) showed multiple enostoses without abnormal focal MDP uptake. Therefore, clinical diagnosis was compatible with osteopoikilosis while bone metastasis was unlikely. The symptoms then improved by conservative treatments. Osteopoikilosis is usually an incidental finding on radiograph or CT, and a normal MDP confirmed the diagnosis by excluding bone metastasis. It is important for clinicians to recognize the specific image features to prevent further unnecessary interventions. In addition, bone SPECT/CT could also make the diagnosis in one step.

  19. Splenic sequestration of Tc-99m labeled heat treated red blood cells. [Feasibility of use for spleen imaging

    Energy Technology Data Exchange (ETDEWEB)

    Atkins, H L; Goldman, A G; Fairchild, R G; Oster, Z H; Som, P; Richards, P; Meinken, G E; Srivastava, S C

    1979-01-01

    The rate of blood clearance and spleen uptake as well as the total spleen uptake of heat damaged red blood cells labeled with Tc-99m was determined in eight patients, six of whom had chronic lymphatic leukemia, one had polycythemia vera and one had eosinophilia of unknown origin. Spleen uptake at 2 hrs was 72.0 +- 18.5%. Approximately 82.6% of the initial radioactivity was cleared from the blood by 2 hrs with a rapid T 1/2 component of 6.3 +- 4.7 min. The T 1/2 of splenic uptake was 8.3 +- 4.6 min with a plateauing of splenic radioactivity by 30 min. The preliminary results indicate that the method of preparation is reliable but the usefulness of the method for evaluating spleen function remains to be determined.

  20. Voxel-based analysis of Tc-99 m ECD brain perfusion SPECT in patients with normal pressure hydrocephalus

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Bora [Department of Neurology, College of Medicine, Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Yang, Dong-Won [Department of Neurology, College of Medicine, Catholic University of Korea, Seoul 137-701 (Korea, Republic of)], E-mail: neuroman@catholic.ac.kr; Shim, Yong-Soo; Chung, Sung-Woo [Department of Neurology, College of Medicine, Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Ahn, Kook-Jin; O, Joo-Hyun; Kim, Sung-Hoon; Sohn, Hyung-Sun; Chung, Soo-Kyo [Department of Radiology, College of Medicine, Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Chung, Yong-An [Department of Radiology, College of Medicine, Catholic University of Korea, Seoul 137-701 (Korea, Republic of); East-West Research Institute of Translational Medicine (EWTM), Incheon St. Mary' s Hospital, Incheon 403-720 (Korea, Republic of)], E-mail: nm@catholic.ac.kr

    2009-07-15

    Idiopathic normal pressure hydrocephalus (iNPH) is a reversible dementia characterized by gait disturbance, incontinence and dementia. This study investigates the neuropsychological characteristics and changes of regional cerebral blood flow (rCBF) in patients with iNPH. Ten patients who met the criteria of probable iNPH and 13 normal control subjects were evaluated. The general cognitive function and detailed neuropsychological functions were measured by K-MMSE and comprehensive neuropsychological battery. Tc-99m-ethyl cysteinate dimmer (Tc-99m-ECD) single photon emission computed tomography (SPECT) was performed to measure the rCBF and statistical parametric mapping (SPM) and statistical probabilistic brain anatomic map (SPAM) was applied to the objective analysis of SPECT data. On the neuropsychological examination, all the patients showed abnormality in memory, psychomotor speed and frontal executive function. SPM analysis of SPECT images revealed that rCBF in bilateral thalami, right prefrontal area, bilateral anterior and posterior cingulate gyri, right caudate nucleus, and left parahippocampal gyrus was significantly decreased in patients with iNPH compared to normal controls (uncorrected P<0.005). In SPAM analysis, rCBF reduction was observed in bilateral prefrontal area, anterior, posterior cingulate gyri and caudate nuclei. We have found that rCBF changes occurred predominantly in prefrontal and subcortical areas, the changes were associated with frontal subcortical circuit, and the affected frontal subcortical circuit may contribute to the cognitive decline seen in the iNPH patients. The reduction of rCBF and clinical cognitive impairment are closely connected in patients with iNPH.

  1. Decisive diagnosis of infected mandibular osteoradionecrosis with a Tc-99m-labelled anti-granulocyte Fab'-fragment

    Energy Technology Data Exchange (ETDEWEB)

    Kampen, W.U.; Brenner, W.; Henze, E. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Terheyden, H. [Kiel Univ. (DE). Clinic of Oral and Maxillofacial Surgery (Germany); Bohuslavizki, K.H. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Nuklearmedizin

    1999-07-01

    The accepted golden standard for detection of inflammatory bone disease is conventional three-phase bone scanning. Hyperperfusion, a high blood-pool activity and elevated bone metabolism are typical signs for an acute osteomyelitis. However, in case of subacute, chronic inflammation, neither elevated blood flow nor high blood-pool activity may be seen. This may cause difficulties in differentiating such cases from neoplastic or postoperative changes. This case report verifies the possible advantage of immunoscintigraphy with Tc-99m-labelled antigranulocyte Fab'-fragments (LeukoScan {sup trademark}) in a patient with infected mandibular osteoradionecrosis, who had equivocal clinical symptomes and questionable radiographic results. LeukoScan {sup trademark} is shown to be more sensitive in case of subacute bone inflammation compared with three-phase bone scanning. However, acquisition of delayed images after 24 hours including SPECT is inevitable in case of negative scans during the first hours of investigation. (orig.) [German] Die konventionelle Drei-Phasen-Skelettszintigraphie ist der Goldstandard in der Diagnostik entzuendlicher Knochenprozesse. Hyperperfusion, hohe Blutpool-Aktivitaet und ein erhoehter Knochenstoffwechsel sind typisch fuer eine akute Osteomyelitis. Bei chronisch-subakut verlaufenden Osteomyelitiden koennen Hyperperfusion und Blutpool-Aktivitaet jedoch fehlen, was zu Schwierigkeiten bei der differentialdiagnostischen Abgrenzung von neoplastischen oder postoperativen Veraenderungen fuehrt. Die vorgestellte Kasuistik belegt den potentiellen Vorteil der Entzuendungs-Szintigraphie mit Tc-99m-markierten Antigranulozyten-Antikoerperfragmenten (LeukoScan {sup trademark}) bei einem Patienten mit infizierter Osteoradionekrose der Mandibula bei untypischer klinischer Symptomatik und unklarer Bildgebung. LeukoScan {sup trademark} erwies sich als sensitiver bei der Diagnose der subakuten ossaeren Entzuendung im Vergleich zur Drei

  2. Preoperative scintigraphic and intraoperative scintimetric localization of parathyroid adenoma with cationic Tc-99m complexes and a hand-held gamma-probe.

    Science.gov (United States)

    Gallowitsch, H J; Fellinger, J; Kresnik, E; Mikosch, P; Pipam, W; Lind, P

    1997-01-01

    The aim of our study was to evaluate the possibility of intraoperative scintimetric detection of parathyroid adenomas with Tc-99m labelled tracers for its usefulness in dystropic or ectopic adenomas. 12 women with biochemically confirmed hyperparathyroidism were included in our study. After injection of 370 MBq Tc-99m tetrofosmin e.g. sestamibi, preoperative scintigraphy (double phase study and SPECT) was performed and T/NT ratios were evaluated for early, delayed and SPECT images. Surgery was performed using a hand-held gamma-probe after preoperative injection of 555-925 MBq Tc-99m tetrofosmin e.g. sestamibi. Count rates (cts/10 sec) were measured and used for calculating in situ- and ex situ-T/NT ratios. In 9 out of 12 patients, adenoma could be detected on static images. Mean T/NT ratios for Tc-99m tetrofosmin were 1.29 for early and 1.23 for delayed images, respectively 1.39 and 1.23 for early and delayed Tc-99m sestamibi scan. Three cases could only be detected with SPECT reconstruction, 11 of 12 parathyroid adenomas could be confirmed intra-operatively. SPECT with Tc-99m labelled cationic complexes showed advantages in detection, precise localization and contrast over static scintigraphy and should therefore be performed at least in cases with poor or no uptake on static images to avoid failures in detection of deeply sited, dislocated glands or adenomas with low uptake. Intraoperative localization and confirmation of parathyroid adenoma with Tc-99m labelled cationic complexes and a gamma probe is possible an 1 may be useful in case of dys- or ectopic adenoma by influencing surgical approach and operating time.

  3. 饮热水联合硝酸异山梨醇酯对贲门失弛缓的治疗作用%Efficacy of Hot Water Drinking Combined with Isosorbide Dinitrate Therapy in Achalasia

    Institute of Scientific and Technical Information of China (English)

    臧凤莉; 王智凤; 柯美云; 方秀才; 孙晓红

    2015-01-01

    Objective To evaluate the efficacy of hot water drinking, isosorbide dinitrate and combination of both in achalasia.Methods The patients with untreated achalasia admitted to Peking Union Medical College Hospital in the period of October 2012 to May 2013 were enrolled and randomly divided into group A ( hot water drinking and combined therapy) and group B (isosorbide dinitrate and combined therapy).Patients in group A received hot water drinking only during the first week, then combined with isosorbide dinitrate from the second to the fourth week.Patients in group B received isosorbide dinitrate only during the first week, then combined with hot water drinking from the second to the fourth week.Clinical symptoms were evaluated at baseline ( 2 weeks before treatment) as well as after 1-week and 4-week treatment.High-resolution manometry and X-ray barium esophagram were evaluated at both baseline and after 4-week treatment.Results A total of 41 patients were in-cluded in this study, 19 in group A and 22 in group B.There was no significant difference in gender, age and course of disease between the two groups ( P>0.05) .Compared with baseline, symptoms were significantly alle-viated after 1-week treatment and after 4-week treatment in group A (P0.05).Compared with baseline, there was no significant reduction in lower esophageal sphincter pressure ( LESP) and integrated relaxation pressure ( IRP) after 4-week treatment in both groups (P>0.05).However, at both baseline and after 4-week treatment, LESP and IRP were significantly decreased after hot water drinking or sublingual isosorbide dinitrate compared with pre-intervention levels in both groups ( P0.05) .Conclusions Hot water drinking or sublingual isosorbide dinitrate could alleviate clinical symp-toms by temporarily decreasing LESP and IPR, which could be amplified by the combination of these two treat-ments, but the effect is not sustained.Hot water drinking combined with sublingual isosorbide dinitrate provides

  4. Bone marrow stem cell adherence into old anterior myocardial infarction: a scintigraphic study using Tl-201 and Tc-99m-HMPAO.

    Science.gov (United States)

    Kollaros, Nikolaos; Theodorakos, Athanasios; Manginas, Athanasios; Kitziri, Elpida; Katsikis, Athanasios; Cokkinos, Dennis; Koutelou, Maria

    2012-04-01

    The precise localization of bone marrow stem cells (SCs) into the necrotic tissue after intracoronary infusion (ICI) may be important for the therapeutic outcome. This study aims to examine the correlation between Tl-201 and Tc-99m-hexa-methyl-propylene-amine-oxime (HMPAO) images. Thirteen patients, aged 36-62 years, with an old, nonviable, anterior myocardial infarction (MI) and reduced myocardial contractility (LVEF Tl-201). Furthermore, two fused bull's eye images of Tc-99m-HMPAO and Tl-201 rest reinjection were created in six patients and regions of interest were set on Tl-201 and Tc-99m-HMPAO bull's eye images. The comparison of the two sets of images revealed an intense accumulation of the SCs in the infarcted area with absence of viability as assessed by Tl-201 reinjection images. In the subset of patients in whom fused bull's eye images were produced, the comparison demonstrated that the percentage of the infarcted area with SCs' adherence was 83.2 ± 17%. Tl-201 images are complementary with the respective Tc-99m-HMPAO ones, revealing a precise localization of SCs in the infarcted area. Tc-99m-HMPAO labeling of SCs is a reliable method for cell monitoring after ICI in nonviable myocardium after an anterior MI.

  5. Diffuse Hepatic and Spleen Uptake of Tc-99m MDP on Bone Scintigraphy Resembling Liver-Spleen Scintigraphy in a Patient of Plasma Cell Tumor.

    Science.gov (United States)

    Ravanbod, Mohammad Reza; Nemati, Reza; Javadi, Hamid; Nabipour, Iraj; Assadi, Majid

    2014-01-01

    The present case demonstrates a diffuse intense hepatic and, to a lesser degree, spleen, Tc-99m MDP uptake on a routine bone scintigraphy resembling liver-spleen imaging. A 49-year-old female with a history of anaplastic plasma cell tumor and suffering from bone pain was referred for bone scintigraphy to evaluate possible bone metastases. The bone scintigraphy showed diffuse hepatic and spleen uptake of Tc-99m MDP resembling liver-spleen imaging. Furthermore, bone uptake of Tc-99m MDP was significantly diminished and there were no abnormal foci throughout the skeleton. The bone scintigraphy of the present case of an anaplastic plasma cell tumor suggests the possible presence of amyloidosis.

  6. Phantom study to evaluate quantitative changes in myocardial radioisotope concentration for single photon emission computed tomography; Comparison between Tl-201 and Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Takashi; Kitabata, Yoshiki; Tanaka, Takeshi; Hasegawa, Mitsuo; Kato, Kazuzo (Cardiovascular Inst., Tokyo (Japan)); Okabe, Akifumi

    1990-01-01

    Quantitative changes in Tl-201 and Tc-99m in myocardial single photon emission computed tomography (SPECT) were evaluated using phantom studies. The absorption rate of gamma ray by the tissues surrounding the myocardium was less for Tc-99m (maximum, 61.2%) than Tl-201 (maximum, 70.8%). In studies on quantification of defects with various concentrations of the radioisotopes, Tc-99m was found superior to Tl-201. In comparing a focal defect in the anterior wall near the surface of the thorax (Defect A) with that in the posterior wall deep in the thorax (Defect B), Defect A had a better quantification than Defect B. Absorber, scattering, and background, however, precluded quantification, especially in Defect B. Although scatter subtraction may in part improve quantification, quantification seemed to be dependent on algorithm in image reconstruction, as well as spatial resolution of the equipment. (N.K.).

  7. Using Tc-99m MIBI scintimammography to differentiate nodular lesions in breast and detect axillary lymph node metastases from breast cancer

    Institute of Scientific and Technical Information of China (English)

    王景; 吴华; 周健; 胡健

    2003-01-01

    Objective To test the clinical value of using Tc-99m MIBI scintimammography (Tc-99m MIBI SMM) to differentiate nodular lesions in breasts and detect axillary lymph node metastases of breast cancer. Methods The subjects consisted of sixty female patients exhibiting unilateral palpable breast mass. The early and delay static acquisitions were undertaken in all subjects at 10 and 90 min after injection with Tc-99m MIBI. The acquisition included three positions: anterior supine, left lateral prone and right lateral prone. A special device for SMM which was developed by our laboratory was used. The ratio of [(T-B)/(NT-B)] was calculated as radioactivity of mass to that of opposite corresponding tissue, and [(T-B)/(NT-B)]≥1.21 was used as the cut-off for semi-quantitative discrimination of malignancy from benignity in semi-quantitative analysis. The final diagnosis was obtained from histology examination in all subjects. Results Using Tc-99m MIBI SMM to differentiate between nodular lesions in breasts, the diagnostic sensitivity and specificity were 92.9% and 90.6% respectively, the positive predictive value 89.7%, the negative predictive value 93.5%, and the accuracy 91.7%. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy obtained with Tc-99m MIBI SMM for detecting axillary lymph node metastases were 83.3%, 86.1%, 80%, 88.6% and 85% respectively. Conclusions It is suggested that Tc-99m MIBI SMM may be not only valuable in differentiating malignant lesions from benign nodular masses of breast, but also helpful in detecting axillary lymph node metastases of breast cancer.

  8. Variable uptake feature of focal nodular hyperplasia in Tc-99m phytate hepatic scintigraphy/single-photon emission computed tomography-A parametric analysis.

    Science.gov (United States)

    Hsu, Yu-Ling; Chen, Yu-Wen; Lin, Chia-Yang; Lai, Yun-Chang; Chen, Shinn-Cherng; Lin, Zu-Yau

    2015-12-01

    Tc-99m phytate hepatic scintigraphy remains the standard method for evaluating the functional features of Kupffer cells. In this study, we demonstrate the variable uptake feature of focal nodular hyperplasia (FNH) in Tc-99m phytate scintigraphy. We reviewed all patients who underwent Tc-99m phytate hepatic scintigraphy between 2008 and 2012 in Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Cases with FNH were diagnosed on the basis of pathology or at least one or more prior imaging with a periodic clinical follow-up. All patients received a standard protocol of dynamic flow study and planar and Tc-99m phytate single-photon emission computed tomography (E. CAM; Siemens). The correlation of variable nodular radioactivity with parameters such as tumor size and localization was analyzed. In total, 15 lesions of 14 patients in the clinic were diagnosed as FNH. The tumor size was approximately 2.9-7.4 cm (mean size 4.6 cm). Four lesions were larger than 5 cm. The major anatomic distribution was in the right hepatic lobe (10 lesions), particularly in the superior segments (7 lesions). Tc-99m phytate single-photon emission computed tomography imaging for determining the functional features of Kupffer cells included cool/cold (8 lesions), isoradioactive/warm (6 lesions), and hot (1 lesion) patterns of uptake. We did not observe any statistically significant correlation between variable nodular radioactivity and tumor size (p=0.68) or localization (p=0.04). Herein, we demonstrate the variable uptake feature of FNH in Tc-99m phytate scintigraphy. In small FNH tumors (< 5 cm), increased or equal uptake still provided specificity for the differential diagnosis of hepatic solid tumors.

  9. Diagnostic capabilities of I-131, TI-201, and Tc-99m-MIBI scintigraphy for metastatic differentiated thyroid carcinoma after total thyroidectomy.

    Directory of Open Access Journals (Sweden)

    Fujie,Shunji

    2005-06-01

    Full Text Available

    We investigated the diagnostic capabilities of I-131, Tl-201, and Tc-99m-MIBI (hexakis-2-methoxyisobutyl- isonitrile scintigraphy for thyroid cancer metastases after total thyroidectomy over the entire body and for every locus before and after thyroid bed ablation. After total thyroidectomy of thyroid cancer, 36 cases were subjected to I-131 treatment 64 times. They consisted of 17 men and 19 women with 31 papillary carcinomas and 5 follicular carcinomas. Their ages were 22--75(an average of 60.5+/-12.3 years. I-131 scintigraphy(I-131, Tl-201 scintigraphy(Tl-201, and Tc-99m- MIBI scintigraphy (Tc-99m-MIBI were performed. We defined the metastases as those cases in which serum thyroglobulin (Tgincreased significantly or in which we were able to prove the lesions on CT (computed tomography, MRI (magnetic resonance imaging or bone scintigram. Three radiology medical specialists visually evaluated each scintigram and calculated the sensitivity, specificity, and likelihood ratio. For whole-body sensitivity, both Tl-201 and Tc-99m-MIBI were high before ablation and I-131 was high after ablation. Before ablation, the negative likelihood ratio was less than 0.1 for Tl-201 and Tc-99m-MIBI, while the positive likelihood ratio was more than 10 for Tl-201. After ablation, the positive likelihood ratio for I-131, Tl-201, and Tc-99m-MIBI was more than 10. The sensitivity of the mediastinum was appropriate, except for I-131 before ablation, and the sensitivity of the lung before and after ablation was inferior for either tracer. The specificity of the cervix for I-131 before ablation was markedly deteriorated, but it increased after ablation.

  10. Review of Extraskeletal Activity on Tc-99m Methylene Diphosphonate Bone Scintigraphy and Value of Cross-Sectional and SPECT-CT Imaging Correlation.

    Science.gov (United States)

    Bermo, Mohammed; Behnia, Sanaz; Fair, Joanna; Miyaoka, Robert S; Elojeimy, Saeed

    2017-07-31

    Recognizing the different mechanisms and imaging appearance of extraskeletal Tc-99m methylene diphosphonate uptake enhances the diagnostic value of bone scan interpretation. In this article, we present a pictorial review of the different mechanisms of extraskeletal Tc-99m methylene diphosphonate uptake on bone scintigraphy including neoplastic, inflammatory, ischemic, traumatic, excretory, and iatrogenic. We also illustrate through case examples the added value of correlation with cross-sectional and single photon emission computed tomography and computed tomography imaging in localizing and characterizing challenging cases of extraskeletal uptake. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Splenic hemochromatosis incidentally found on Tc-99m MDP bone scan in a chronic myelogenous leukemia patient who received bone marrow transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol; Seo, Ji Hyoung; Bae, Jin Ho; Jeong, Sin Young; Lee, Jae Tae; Lee, Kyu Bo [School of Medicine, Kyungpook National Univ., Daegu (Korea, Republic of)

    2004-02-01

    Tc-99m MDP bone scan was performed to evaluate a generalized bone pain in a 24-year-old male chronic myelogenous leukemia patient who received bone marrow transplantation at 7 months ago. The patient had received large amounts of blood transfusion for managing symptoms related to anemia. Bone scan revealed substantial splenic tracer uptake. Magnetic resonance image and laboratory evidence of hemochromatosis suggests that the presence of large quantities of iron in the spleen of this patient may have been responsible for the splenic uptake of the bone scanning agent. The authors report a c ase of splenic hemochromatosis incidentally found on Tc-99m MDP bone scan.

  12. Distribution of lung blood on modified bilateral Glenn shunt evaluated by Tc-99m-MAA lung perfusion scintigraphy

    Science.gov (United States)

    Si, Biao; Luan, Zhao-sheng; Wang, Tong-jian; Ning, Yan-song; Li, Na; Zhu, Meng; Liu, Zhong-min; Ding, Guang-hong; Qiao, Bin

    2016-01-01

    Abstract The aim of the present study was to determine the distribution of lung blood in a modified bilateral Glenn procedure designed in our institute with lung perfusion scintigraphy. Sixteen consecutive patients who underwent modified bilateral Glenn operation from 2011 to 2014 were enrolled in the study. The control group consisted of 7 patients who underwent bidirectional Glenn shunt. Radionuclide lung perfusion scintigraphy was performed using Tc-99m-macro aggregated albumin (MAA) in all patients. For the patients in modified bilateral Glenn group, the time at which the radioactivity accumulation peaked did not differ significantly between the right and left lung field (t = 0.608, P = 0.554). The incidence of perfusion abnormality in each lung lobe also did not differ significantly (P = 0.426 by Fisher exact test). The radioactive counts were higher in the right lung than in the left lung, but the difference was not statistically significant (t = 1.502, P = 0.157). Radioactive perfusion in the lower lung field was significantly greater than that in the upper field (t = 4.368, P lung to that in left lung was significantly lower in the modified bilateral Glenn group (t = 3.686, P = 0.002). Lung perfusion scintigraphy confirmed the benefit of the modified bilateral Glenn shunt with regard to more balanced blood perfusion in both lungs. PMID:27661042

  13. Is Tc99m-MIBI scintigraphy a predictor of response to pre-operative neoadjuvant chemotherapy in Osteosarcoma?

    Directory of Open Access Journals (Sweden)

    Vahidreza Dabbagh Kakhki

    2013-10-01

    Full Text Available Objectives: Multidrug resistance (MDR, which may be due to the over expression of P-glycoprotein (Pgp and/or MRP, is a major problem in neoadjuvant chemotherapy of osteosarcoma. The aim of this study was to investigate the role of Tc-99m MIBI scan for predicting the response to pre-operative chemotherapy. Materials and Methods: Twenty-five patients (12 males and 13 females, aged between 8 and 52y with osteosarcoma were studied. Before the chemotherapy, planar 99mTc-MIBI anterior and posterior images were obtained 10-min [tumor-to-background ratio: (T1/B110min] and 3-hr after tracer injection. After completion of chemotherapy, again 99mTc-MIBI scan was performed at 10-min after tracer injection. In addition to calculation of decay corrected tumor to background (T/B ratios ,  using the 10-min and 3-hr images of the pre-chemotherapy scintigraphy , percent wash-out rate (WR% of 99mTc-MIBI was calculated. Using the 10-min images of the pre- and post-chemotherapy scans, the percent reduction in uptake at the tumor site after treatment (Red% was also calculated. Then after surgical resection, tumor response was assessed by percentage of necrosis. Results: All patients showed significant 99mTc-MIBI uptake in early images. Only 9 patients showed good response to chemotherapy (necrosis≥90% while 16 patients were considered as non-responder (necrosis

  14. Tc-99m technegas scintigraphy to evaluate the lung ventilation in patients with oral corticosteroid-dependent bronchial asthma

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, Jiro; Okada, Hiroki; Momoi, Atsuko; Yamadori, Ichiro; Takahara, Jiro; Tanabe, Masatada [Kagawa Medical Univ., Miki (Japan); Takahashi, Kazue; Satoh, Katashi; Ohkawa, Motoomi

    1999-08-01

    Bronchial asthma is a clinical syndrome characterized by the reversibility of airway obstruction. Recently it has been suggested that remodeling of the airway causes irreversible airway obstruction which may be responsible for the patient's symptoms. With this background, the purpose of the present study was to assess patients with corticosteroid-dependent asthma by Tc-99m Technegas scintigraphy (Technegas) in both planar and SPECT images. Twelve patients (7 females and 5 males aged 36-72 years with a median age of 60 years: 4 smokers and 8 non-smokers) with oral corticosteroid-dependent asthma were enrolled in this study. Lung ventilation scanning with Technegas in both planar and SPECT images, high-resolution computed tomography, and pulmonary function tests were performed in all patients. The results of Technegas scanning were graded and correlations with other clinical parameters were evaluated. Significant abnormalities were detected by ventilation scintigraphy with Technegas in patients with corticosteroid-dependent bronchial asthma even during remission. Our data demonstrate that airflow obstruction took place in patients with corticosteroid-dependent asthma even during remission. Technegas scanning appears to be a useful radiopharmaceutical for demonstrating airflow obstruction in patients with bronchial asthma. (author)

  15. [Perfusion myocardial scintigraphy - SPECT with TC-99m MIBI in detection coronary artery desease in diabetic patients].

    Science.gov (United States)

    Heljić, Bećir; Kucukalić-Selimović, Elma; Begić, Alden; Begić, Amela

    2007-01-01

    Diabetes mellitus is very frequent disease. The prevalence of coronary artery disease is higher in diabetic than in non-diabetic patients. Coronary artery disease (CAD) is the main cause of morbidity and mortalitiy in patients with Diabetes mellitus. The aim of this study was to evaluate usfulnes of myocardial perfusion scintigraphy in diabetic patients for detection of coronary artery disease. this study included 15 patients with verified diabetes mellitus. All patients were treated with oral hypoglicemic or insulin. Parameters observed for every patients were level of lipemia (cholesterol, triglycerides), family hystory of CAD, hystory of chest pain. All patients underwent sress/rest Tc-99m MIBI study. We have performed one day protocol. Exercise tolerance test were performing in all patients according to the Bruce protocol. 260MBq was injected intravenously at peak exercise. 740MBg was injected for the rest. Myocardial perfusion scintigraphy was clasified as: 1. normal, 2. reversible defect or 3. irreversible defect. reversible perfusion defect we have found in 8 patients. The same patients had elevated glicemia, high level of lipemia; 1 patient had fixed defect, without any previous known history for myocardial infarction. In 6 patients we could not see any significant defect during stress/rest scintigraphy. The frequency of abnormal myocardial perfusion scintigraphy suggest that this procedure can be very useful in the detection of high-risk diabetic patients.

  16. Preoperative scintigraphic and intraoperative scintimetric localization of parathyroid adenoma with cationic Tc-99m complexes and a hand-held gamma-probe

    Energy Technology Data Exchange (ETDEWEB)

    Gallowitsch, H.J. [Dept. of Nuclear Medicine and Special Endocrinology, Landeskrankenhaus Klagenfurt (Austria); Fellinger, J. [Dept. of Surgery, Landeskrankenhaus Klagenfurt (Austria); Kresnik, E. [Dept. of Nuclear Medicine and Special Endocrinology, Landeskrankenhaus Klagenfurt (Austria); Mikosch, P. [Dept. of Nuclear Medicine and Special Endocrinology, Landeskrankenhaus Klagenfurt (Austria); Pipam, W. [Dept. of Mental Health, Landeskrankenhaus Klagenfurt (Austria); Lind, P. [Dept. of Nuclear Medicine and Special Endocrinology, Landeskrankenhaus Klagenfurt (Austria)

    1997-01-01

    Aim: The aim of our study was to evaluate the possibility of intraoperative scintimetric detection of parathyroid adenomas with Tc-99m labelled tracers for its usefulness in dystopic or ectopic adenomas. Methods: 12 Women with biochemically confirmed hyperparathyroidism were included in our study. After injection of 370 MBq Tc-99m tetrofosmin e.g. sestamibi, preoperative scintigraphy (double phase study and SPECT) was performed and T/NT ratios were evaluated for early, delayed and SPECT images. Surgery was performed using a handheld gamma-probe after preoperative injection of 555-925 MBq Tc-99m tetrofosmin e.g. sestamibi. Count rates (cts/10 sec) were measured and used for calculating in situ - and ex situ - T/NT ratios. Results: In 9 out of 12 patients, adenoma could be detected on static images. Mean T/NT ratios for Tc-99m tetrofosmin were 1.29 for early and 1.23 for delayed images, respectively 1.39 and 1.23 for early and delayed Tc-99m sestamibi scan. Three cases could only be detected with SPECT reconstruction. 11 of 12 parathyroid adenomas could be confirmed intraoperatively. Conclusion: SPECT with Tc-99m labelled cationic complexes showed advantages in detection, precise localization and contrast over static scintigraphy and should therefore be performed at least in cases with poor or no uptake on static images to avoid failures in detection of deeply sited, dislocated glands or adenomas with low uptake. Intraoperative localization and confirmation of parathyroid adenoma with Tc-99m-labelled cationic complexes and a gamma probe is possible and may be useful in case of dys- or ectopic adenoma by influencing surgical approach and operating time. (orig.) [Deutsch] Ziel: Ziel unserer Untersuchung war es, die Moeglichkeit des intraoperativen szintimetrischen Nachweises von NSD-Adenomen mit Tc-99m-markierten Komplexverbindungen fuer den eventuellen Einsatz bei ektopen NSD-Adenomen zu ueberpruefen. Methoden: 12 Frauen mit biochemisch gesichertem

  17. Role of scintigraphy with Tc-99m-infliximab in predicting the response of intraarticular infliximab treatment in patients with refractory monoarthritis

    NARCIS (Netherlands)

    Conti, F.; Malviya, G.; Ceccarelli, F.; Priori, R.; Iagnocco, A.; Valesini, G.; Signore, A.

    2012-01-01

    The rationale for the present study was to evaluate the predictive role of Tc-99m-infliximab scintigraphy in therapy decision-making in patients with refractory monoarthritis and also candidates for intraarticular (IA) infliximab treatment. We studied 12 patients (5 with rheumatoid arthritis and 7 w

  18. P-gp and MRP1 Expression in Parathyroid Tumors Related to Histology, Weight and Tc-99m-Sestamibi Imaging Results

    NARCIS (Netherlands)

    Jorna, F. H.; Hollema, H.; Hendrikse, H. N.; Bart, J.; Brouwers, A. H.; Plukker, J. T. M.

    2009-01-01

    Objective: P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) are membrane efflux pumps that may have a role in the kinetics of Tc-99m-sestamibi (MIBI) in parathyroid tumors. P-gp and MRP1 expression in parathyroid tumors was studied and related to histology, weight and pre- and

  19. Tc-99m DTPA perfusion scintigraphy and color coded duplex sonography in the evaluation of minimal renal allograft perfusion

    Energy Technology Data Exchange (ETDEWEB)

    Bair, H.J.; Platsch, G.; Wolf, F. [Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Nuclear Medicine; Guenter, E.; Becker, D. [Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Internal Medicine 1; Rupprecht, H.; Neumayer, H.H. [Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Internal Medicine 4

    1997-08-01

    Aim: The clinical impact of perfusion scintigraphy versus color coded Duplex sonography was evaluated, with respect to their potential in assessing minimal allograft perfusion in vitally threatened kidney transplants, i.e. oligoanuric allografts suspected to have either severe rejection or thrombosis of the renal vein or artery. Methods: From July 1990 to August 1994 the grafts of 15 out of a total of 315 patients were vitally threatened. Technetium-99m DTPA scintigraphy and color coded Duplex sonography were performed in all patients. For scintigraphic evaluation of transplant perfusion analog scans up to 60 min postinjection, and time-activity curves over the first 60 sec after injection of 370-440 MBq Tc-99m diethylenetriaminepentaacetate acid (DTPA) were used and classified by a perfusion score, the time between renal and iliac artery peaks (TDiff) and the washout of the renogram curve. Additionally, evaluation of excretion function and assessment of vascular or urinary leaks were performed. By color coded Duplex sonography the perfusion in all sections of the graft as well as the vascular anastomoses were examined and the maximal blood flow velocity (Vmax) and the resistive index (RI) in the renal artery were determined by means of the pulsed Doppler device. Pathologic-anatomical diagnosis was achieved by either biopsy or post-explant histology in all grafts. Results: Scintigraphy and color coded Duplex sonography could reliably differentiate minimal (8/15) and not perfused (7/15) renal allografts. The results were confirmed either by angiography in digital subtraction technique (DSA) or the clinical follow up. Conclusion: In summary, perfusion scintigraphy and color coded Duplex sonography are comparable modalities to assess kidney graft perfusion. In clinical practice scintigraphy and colorcoded Doppler sonography can replace digital subtraction angiography in the evaluation of minimal allograft perfusion. (orig.) [Deutsch] Ziel der Studie war es, das

  20. Accumulation of Tc-99m HL91 in Tumor Hypoxia: In Vitro Cell Culture and In Vivo Tumor Model

    Directory of Open Access Journals (Sweden)

    Bi-Fang Lee

    2008-09-01

    Full Text Available Hypoxic cells within a tumor can account, in part, for resistance to radiotherapy and chemotherapy. Indeed, the oxygenation status has been shown to be a prognostic marker for the outcome of therapy. The purpose of this study was to determine whether Tc-99m HL91 (HL91, a noninvasive imaging tracer, detects tumor hypoxia in vitro in cell culture and in vivo in a tumor model. Uptake of HL91 in vitro into human lung cancer cells (A549 and murine Lewis lung cancer cells (LL2 was investigated at oxygen concentrations of 20% O2 (normoxia, and 1% O2 (hypoxia. HL91 biodistribution was studied in four groups: severe combined immune deficiency (SCID mice bearing A549 tumors, C57BL/6NCrj (B6 mice bearing LL2 tumors, SCID controls, and B6 controls. Accumulation of the tracer was compared between tumors treated with hydralazine or phosphate-buffered saline (PBS. Scintigraphic images were obtained for hydralazine-treated mice and PBS-treated mice in each of the four study groups. Autoradiography of tumor slices was also acquired. In vitro studies identified hypoxia-selective uptake of HL91, with significantly increased uptake in the hypoxic state than in the normoxic state. Biodistribution and scintigraphy showed increased HL91 uptake during tumor hypoxia at 0.5 hours, and there was progressively increased activity for up to 4 hours after tracer administration. HL91 accumulation in tumor hypoxia was markedly increased in mice treated with hydralazine compared with those treated with PBS. Autoradiography revealed high HL91 uptake in the peripheral areas around the necrotic regions of the tumor, which were identified by histologic examination. HL91 exhibits selectivity for tumor hypoxia both in vitro and in vivo and provides a successful imaging modality for the detection of tumor hypoxia in vivo.

  1. Activity measurements of the radionuclide 99mTc for the VNIIM, Russian Federation and ENEA-INMRI, Italy, in the ongoing comparison BIPM.RI(II)-K4.Tc-99m and KCRV update in the BIPM.RI(II)-K1.Tc-99m comparison

    Science.gov (United States)

    Michottea, C.; Nonisa, M.; Alekseevb, I. V.; Kharitonovb, I. A.; Tereshchenkob, E. E.; Zanevskiyb, A. V.; Capognic, M.; De Felicec, P.; Fazioc, A.; Carconic, P.

    2016-01-01

    In 2014, comparisons of activity measurements of 99mTc using the Transfer Instrument of the International Reference System (SIRTI) took place at the VNIIM (Russian Federation) and at the ENEA-INMRI (Italy), with comparison identifier BIPM.RI(II)-K4.Tc-99m. Ampoules containing about 32 kBq of 99mTc solutions were measured in the SIRTI for three half-lives. There are now nine results in the BIPM.RI(II)-K4.Tc-99m comparison. This comparison is linked to the BIPM.RI(II)-K1.Tc-99m comparison and the key comparison reference value (KCRV) of the BIPM.RI(II)-K1.Tc-99m has been updated to include eligible results from BIPM.RI(II)-K4.Tc-99m. The degrees of equivalence between each equivalent activity measured in the SIR or the SIRTI and the KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  2. Is Tc99m-MIBI scintigraphy a predictor of response to pre-operative neoadjuvant chemotherapy in Osteosarcoma?

    Directory of Open Access Journals (Sweden)

    Mohammad Gharehdaghi

    2013-10-01

    Full Text Available Introduction: Multidrug resistance (MDR, which may be due to the over expression of P-glycoprotein (Pgp and/or MRP, is a major problem in neoadjuvant chemotherapy of osteosarcoma. The aim of this study was to investigate the role of Tc-99m MIBI scan for predicting the response to pre-operative chemotherapy. Materials and Methods: Twenty-five patients (12 males and 13 females, aged between 8 and 52y with osteosarcoma were studied. Before the chemotherapy, planar 99mTc-MIBI anterior and posterior images were obtained 10-min [tumor-to-background ratio: (T1/B110min] and 3-hr after tracer injection. After completion of chemotherapy, again 99mTc-MIBI scan was performed at 10-min after tracer injection. In addition to calculation of decay corrected tumor to background (T/B ratios , using the 10-min and 3-hr images of the pre-chemotherapy scintigraphy , percent wash-out rate (WR% of 99mTc-MIBI was calculated. Using the 10-min images of the pre- and post-chemotherapy scans, the percent reduction in uptake at the tumor site after treatment (Red% was also calculated. Then after surgical resection, tumor response was assessed by percentage of necrosis. Results: All patients showed significant 99mTc-MIBI uptake in early images. Only 9 patients showed good response to chemotherapy (necrosis≥90% while 16 patients were considered as non-responder (necrosis<90%. There was no statistical significant difference between non-responders and responders in (T1/B110min.There was a significant negative correlation between WR% and percentage of necrosis (P=0.001. On the other hand, there was a significant correlation between Red% and percentage of necrosis (P<0.001.There was also statistical significant difference in WR% and Red% between non-responders and responders (both P< 0.001. Conclusion: Washout rate of 99mTc-MIBI in pre-chemotherapy scintigraphy as well as Red% using pre- and post-chemotherapy MIBI scintigraphy are useful methods for predicting response to

  3. Quantitative Tc-99m DTPA renal transplant scintigraphy predicts graft survival in the very early postoperative period.

    Science.gov (United States)

    Gupta, Sandeep K; Lewis, Guy; Rogers, Kerry; Attia, John

    2012-12-01

    Early evaluation of renal allograft prognosis is important for identification and targeted management of 'at-risk' grafts but is difficult in the absence of established tests. Tc-99m diethylene triamine pentaacetic acid renal transplant scintigraphy is a useful noninvasive method for assessing graft function. We aimed to assess the relative role of quantitative scintigraphic parameters in the immediate postoperative period for the assessment of short-term and long-term prognoses. Data from 290 dynamic renal transplant scintigraphy procedures, performed on 161 recipients on day 1 (D1) or day 4 (D4) after transplantation, were analysed to derive various perfusion parameters [Kirchner's Index, Hilson's Index (HI), kidney-to-aorta ratio and ΔP] as well as nonperfusion parameters (graft washout t (1/2), P : PI ratio, P : U ratio, R20/3, T10 and T20) using regions of interest within the whole renal graft and iliac artery. Information on graft survival up to 1 year (as a measure of short-term prognosis) and serum creatinine at 1 year (regarded as a predictor for longer-term prognosis) was collected. Mann-Whitney tests, receiver-operating characteristic curve analyses and odds ratios were used to assess the utility of each parameter in stratifying the risk for graft failure within 1 year. Correlations between each parameter and 1-year serum creatinine were tested using Spearman's rank correlation. Eleven grafts failed within 1 year. All perfusion parameters on both D1 and D4 showed significant differences between the failure and survival groups (P=0.026-0.0005). No significant between-group differences were observed for nonperfusion parameters except for R20/3 on D1 (P=0.0298). Receiver-operating characteristic analysis showed moderate accuracy for HI and ΔP on both D1 and D4 (area under the curve: 0.73-0.84); ΔP of longer than 6.0 s on D4 was associated with 24.9 times higher relative risk for graft failure within 1 year (sensitivity 88% and specificity 83%). For the

  4. Diagnostic sensitivity of Tc-99m HYNIC PSMA SPECT/CT in prostate carcinoma: A comparative analysis with Ga-68 PSMA PET/CT.

    Science.gov (United States)

    Lawal, Ismaheel O; Ankrah, Alfred O; Mokgoro, Neo P; Vorster, Mariza; Maes, Alex; Sathekge, Mike M

    2017-08-01

    Emerging data from published studies are demonstrating the superiority of Ga-68 PSMA PET/CT imaging in prostate cancer. However, the low yield of the Ge-68/Ga-68 from which Gallium-68 is obtained and fewer installed PET/CT systems compared to the SPECT imaging systems may limit its availability. We, therefore, evaluated in a head-to-head comparison, the diagnostic sensitivity of Ga-68 PSMA PET/CT and Tc-99m PSMA SPECT/CT in patients with prostate cancer. A total of 14 patients with histologically confirmed prostate cancer were prospectively recruited to undergo Ga-68 PSMA PET/CT and Tc-99m HYNIC PSMA SPECT/CT. The mean age of patients was 67.21 ± 8.15 years and the median PSA level was 45.18 ng/mL (range = 1.51-687 ng/mL). SUVmax of all lesions and the size of lymph nodes with PSMA avidity on Ga-68 PSMA PET/CT were determined. Proportions of these lesions detected on Tc-99m HYNIC PSMA SPECT/CT read independent of PET/CT findings were determined. A total of 46 lesions were seen on Ga-68 PSMA PET/CT localized to the prostate (n = 10), lymph nodes (n = 24), and bones (n = 12). Of these, Tc-99m HYNIC PSMA SPECT/CT detected 36 lesions: Prostate = 10/10 (100%), lymph nodes = 15/24 (62.5%), and bones = 11/12 (91.7%) with an overall sensitivity of 78.3%. Lesions detected on Tc-99m HYNIC PSMA SPECT/CT were bigger in size (P PET/CT compared to those lesions that were not detected. All lymph nodes greater than 10 mm in size were detected while only 28% of nodes less than 10 mm were detected by Tc-99m HYNIC PSMA SPECT/CT. In a univariate analysis, Lymph node size (P = 0.033) and the SUVmax of all lesions (P = 0.007) were significant predictors of lesion detection on Tc-99m HYNIC PSMA SPECT/CT. Tc-99m HYNIC PSMA may be a useful in imaging of prostate cancer although with a lower sensitivity for lesion detection compared to Ga-68 PSMA PET/CT. Its use is recommended when Ga-68 PSMA is not readily available, in planning radio

  5. Cumulated activities determined from biodistribution data in pregnant rats ranging from 13 to 21 days gestation. I. Tc-99m pertechnetate.

    Science.gov (United States)

    Wegst, A V; Goin, J E; Robinson, R G

    1983-01-01

    Cumulated activity estimates for Tc-99m pertechnetate were determined using biodistribution data from pregnant and nonpregnant rats. The pregnant rats were studied at 13, 15, 17, 19, and 21 days gestation. The results indicate that maternal organ cumulated activities are not a simple function of gestational age. The organs into which Tc-99m pertechnetate enters through passive diffusion follow the pattern established by the blood, generally resulting in an increase from the 13th through the 17th day with a decrease on the 19th and 21st day. The organs dominated by active transport follow unique and different patterns. The fetal cumulated activity estimates increased exponentially with gestational age and the placental estimates increased linearly.

  6. Evaluation of the phagocitary capacity of the mononuclear system in an experimental model of obstructive jaundice employing Tc- 99m Escherichia coli

    Directory of Open Access Journals (Sweden)

    Simone Odília Fernandes Diniz

    2005-10-01

    Full Text Available Infections and endotoxemia continue to be the principal causes of morbidity and mortality of patients with obstructions of the bile duct. The objective of the present work was the investigation of the phagocitary capacity of the mononuclear system in an experimental model of obstructive jaundice utilizing Tc-99m E.coli. The levels of aspartate aminotransferase (AST, alanine aminotransferase (ALT and alkaline phosphatase (ALP were significantly higher in jaundiced rats than in the control animals (p Nos pacientes com obstrução do ducto biliar, as infecções e a endotoxemia continuam sendo uma das principais causas de morbidade e mortalidade. O objetivo desse trabalho foi investigar a capacidade fagocitária do sistema mononuclear, em um modelo experimental de icterícia obstrutiva, utilizando Tc-99m E.coli. Os níveis de aspartato aminotransferase (AST, alanina aminotransferase (ALT e fosfatase alcalina (PAL nos ratos com ligadura do ducto biliar comum (CBD encontram-se significativamente mais elevados do que nos ratos sham. (p < 0.001. O fígado dos animais ictéricos apresentou uma significativa redução na captação da Tc-99m E.coli quando comparado com o controle. Os dados mostraram também, que houve um aumento significativo na captação da Tc-99m E.coli pelo pulmão dos ratos ictéricos (p < 0.01. O exame histológico dos cortes de fígado dos animais ictéricos apresentou proliferação intensa e difusa dos ductos biliares e uma acentuada poliploidia dos hepatócitos (volume médio: 843 µm³, Não foram observadas alterações significativas nos pulmões de nenhum grupo.

  7. Evaluation of mandibular bone involvement by oral malignant tumors using scintigraphy of Tc-99m MDP and Ga-67 citrate. Intensely invaded cases

    Energy Technology Data Exchange (ETDEWEB)

    Katada, Yoshiaki; Tsuchimochi, Makoto; Kato, Joji

    1987-12-01

    Ten patients with intensely invaded malignant tumors at the mandibles were studied with bone scintigraphy (Tc-99m MDP) and Ga-67 citrate scintigraphy. All patients were classified by type of accumulation of both radionuclide pharmaceuticals. In almost all patients with invaded malignant tumors, bone scintigraphy revealed decreasing uptake in the center of the lesion and increasing uptake in the peripheral region. Ga-67 citrate scintigram showed increasing concentrated accumulation which was smaller than the area of Tc-99m MDP uptake in almost all cases. These types of accumulation were compared with those of other oral and maxillo-facial diseases. The patterns of accumulation of both radionuclide pharmaceuticals in ameloblastoma (3 cases), radicular cyst (3 cases), bone fracture (2 cases), diffuse sclerosing osteomyelitis (2 cases), and one sagittal ramus osteotomy case were different from that of bone involvement of malignant tumor cases. From the types of accumulation, we may be able to differentiate the oral and maxillo-facial diseases to some extent. In addition, the intensity of accumulation of Tc-99m MDP was measured by using bone to soft tissue ratio (4 hrB/St ratio). The mean 4 hrB/St ratio was higher in moth-eaten absorbed type than in permeated type of resorption in roentgenogram. However, we could not obtain a definitive conclusion because of too few cases. The mean 4 hrB/St ratio in the bone involvement by malignant tumor was higher than that in radicular cyst, and lower than that of diffuse sclerosing osteomyelitis. Unfortunately, we could not differentiate each disease of the involved malignant tumor, ameloblastoma, or bone fracture by only the 4 hrB/St ratio. The Tc-99m MDP accumulated beyond the region where the radiolucencies exist in roentgenograms. We consider that both scintigraphies have a great role in planning surgical treatment, especially in selecting osteotomy.

  8. Blood flow and tracer uptake in normal and abnormal canine bone: comparisons with Sr-85 microspheres, Kr-81m, and Tc-99m MDP

    Energy Technology Data Exchange (ETDEWEB)

    Lavender, J.P.; Khan, R.A.A.; Hughes, S.P.F.

    1979-05-01

    The bone scan, showing the 4-hr residue in bone of technetium diphosphonate, is a widely used diagnostic tool. The question arises whether it reflects changes in local blood flow to bone, or avidity, or both. Two experimental approaches have been used in trying to answer this question. The first was to determine immediate single-passage clearance and 4-hr residue in normal and abnormal bone. If flow is the determinant of residue these should be the same since, in this event, extraction will not change. An osteotomy was produced in the dog tibia and retrograde catheterization of the anterior tibial artery allowed measured amounts of technetium-methylene-diphosphonate (Tc-99m MDP), to be infused into the nutrient artery. Similar preparation in normal bone allowed comparison of both clearance and 4-hr residue. Results have shown increased 4-hr residue 10 days after the osteotomy (normal 4.9% ..-->.. 13.4%). The second approach involved use of a gamma camera to record profiles of blood flow in normal and abnormal bone: (a) by injecting Sr-85 microspheres into the nutrient artery, and (b) by infusing the short-lived radioactive gas, krypton-81m, thus producing an image of regional distribution of flow. Comparison of these profiles with the distribution of Tc-99m MDP shows that a moderate increase in flow is associated with a much greater increase in Tc-99m MDP residue. We conclude that, although blood flow is one determinant of the distribution of bone-seeking radionuclides such as Tc-99m MDP, some other determinants of clearance and residue explain their localization.

  9. Metastatic Neuroendocrine Carcinoma of the Breast Identified by Tc-99m-HYNIC-TOC SPECT/CT: A Rare Case Report.

    Science.gov (United States)

    Claimon, Apichaya; Chuthapisith, Suebwong; Samarnthai, Norasate; Pusuwan, Pawana

    2015-08-01

    The authors reported an uncommon presentation of metastatic neuroendocrine carcinoma to the breast detected by Tc-99m-HYNIC-TOC SPECT/CT in a 49 years old woman who, previously, had carcinoid tumor of left main bronchus and invasive ductal carcinoma of the right breast. Later, the patient developed left breast mass. Core needle biopsy of the mass revealed poorly differentiated invasive ductal carcinoma. The disease remained stable for 12 years without any treatment on that left breast (due to patient's rejection). On the later investigation using Tc-99m-HYNIC-TOC scintigraphy examination, rather than invasive ductal carcinoma, metastatic neuroendocrine cancer was suggested. The final diagnosis was confirmed by pathological examination after surgical excision. Multiple metastatic lesions of neuroendocrine carcinoma at lung, liver, ovaries, and bones were also depicted. Due to the good behavior of the disease, patient had been doing well for eight months, without specific treatment. This report confirmed the advantage and the accuracy of Tc-99m-HYNIC-TOC scintigraphy in detection of neuroendocrine carcinoma. Furthermore, metastatic neuroendocrine tumor should be in differential diagnosis for patient with breast mass together with history of neuroendocrine tumor

  10. Influence of the irradiation time on the activity of decay products during the cooling. Case: Mo-98 {yields} Mo-99 {yields} Tc-99m; Influencia del tiempo de irradiacion en la actividad de los productos de decaimiento durante el enfriamiento. Caso: Mo-98 {yields} Mo-99 {yields} Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Reyes J, J.L.; Ruiz C, M.A.; Alanis M, J. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    In this work the behavior of the activity in the cooling time of Mo-99, Tc-99 and Tc-99m obtained by Neutron activation of natural Mo is described. The analytical development is based on the application of the Laplace transform for resolving the balance equations. (Author)

  11. Change of cerebral blood flow distribution and vascular reserver according to age in Koreans measured by Tc-99m HMPAO brain SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ho Cheon; Bom, Hee Seung; Sohn, Hye Kyung; Jeong, Hwan Jeong; Min, Jung Jun; Kim, Ji Yeol [College of Medicine, Chonnam National Univ., Kwangju (Korea, Republic of); Lee Jae Tae [College of Medicine, Kyungpook National Univ., Taegu (Korea, Republic of); Moon, Dae Hyuk; Lee, Hee Kyung [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    1999-02-01

    The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3{+-}24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalamic rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9{+-}12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. Quantitative assessment of CVR was possible by ACZ Tc-99m MHPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference.

  12. Puesta a punto "In Vivo" de un modelo de aclaramiento mucociliar mediante microCT-SPECT-TC99m con nanocoloides de albumina en cobaya

    OpenAIRE

    PÉREZ LEAL, MARTÍN

    2015-01-01

    [ES] Con este trabajo se pretende poner a punto en el laboratorio un modelo "in vivo" de aclaramiento mucociliar mediante tomografía computerizada de emisión monofotónica (SPECT) en cobaya para su uso en ensayos farmacologicos de nuevos tratamientos para enfermedades respiratorias. Para ello, se utilizarán nanocoloides de albumina marcados con Tc99m y tres dosis de amilorida, fámaco que ha demostrado por otras técnicas su efecto en mejorar la actividad mucociliar. Este método podría ser una...

  13. Comparison study of lesion localization in patients with primary and secondary hyperparathyroidism using double-phase Tc-99m sestamibi scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Tae Joo; Lee, Jong Doo; Rhyu, Young Hoon; Park, Jung Soo; Jang, Hang Seok [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    1999-08-01

    The purpose of this study was to evaluate and compare the scintigraphic findings and diagnostic accuracy of double-phase Tc-99m sestamibi scan in primary and secondary hyperparathyroidism (HPT). We retrospectively reviewed 16 cases of primary (18 lesions) and 11 cases of secondary HPT (44 lesions) who underwent Tc-99m-sestamibi scan before the surgical intervention. Scan was performed using LEM camera (Siemens, Germany ) after the injection of 740MBq of Tc-99m sestamibi. Routine image consisted of baseline and 3-hour delayed images and each image was obtained using both parallel and pine hole collimator. The study population was 27 patients (male/ females=5/22, age: 49.1{+-}10.8). Eighteen lesions of primary HPT consisted of 13 adenomas and 5 hyperplasias, while while all lesions of secondary but only 2 lesions of 5 hyperplasias, while all lesions of secondary HPT were hyperplasias. Among the case of primary HPT, we could detect all the lesions of 13 adenomas but only 2 lesions of 5 hyperplasias (40%) could be detected by double phase scintigraphy. Three cases of primary lesion showed decreased uptake in delayed images compared with baseline. The sensitivity, specificity, positive predictive value and accuracy of primary and secondary HPT were 58.5% (10/17), 83.3% (10/12), 83.3%(10/12), 75.9%(22/29), and 37.5%(15/40), 50% (2/4), 88.2% (15/17), 38.6% (17/44), respectively. Overall sensitivity, specificity, positive predictive value and accuracy were 43.9% (25/57), 75%(12/16), 86.2% (25/29), and 53.4% (39/73). There were no statistical difference between the weight of primary and secondary HPT lesion (p>0.05). Tc-99m sestamibi scan is fairly good modality to detect parathyroid lesion in patient with primary HPT before the surgical intervention. However, since some of cases may reveal decreased uptake in delayed image, a careful attention to the findings of baseline images may be helpful. Still the low accuracy of sestamibi scan in diagnosis of secondary HPT prohibits

  14. In vivo prediction of anti-tumor effect of 3-bromopyruvate in hepatocellular carcinoma using Tc-99m labeled annexin-v imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Won; Yoon, Jung Hwan; Kim, Chung Yang [Seoul National University College of Medicine, Seoul (Korea, Republic of); Cheon, Gi Jeoog; Lee, Tae Sup; Woo, Kwang Sun; Chung, Wee Sup [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2005-07-01

    We have recently demonstrated that hypoxia stimulates hepatocellular carcinoma (HCC) cell growth through hexokinase II induction, and its inhibition induces apoptotic cell death through activating mitochondrial apoptotic signaling cascades. In this study, we were apt to evaluate the antitumoral effect of 3-bromopyruvate (3-BP) on in vivo model of HCC by apoptotic imaging using Tc-99m labeled annexin V. In vivo model of HCC was established in C3H mice intradermally implanted with MH134 cells, a mouse HCC cell line, and 3-BP (0, 5, 10 mg/kg) was subsequently administered intraperitoneally. Tc-99m-HYNIC-annexin V (185 KBq) was injected via tail vein at one and three days after the 3-BP treatment, planar scan was acquired at a hour after the injection using gamma camera. The anti-tumor effect was evaluated by measuring tumor volumes and quantification of apoptotic cells using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. Tumor volume was significantly reduced in mice treated with 3-BP in a dose-dependent manner (mean tumor volume 1.07 vs. 0.58 vs. 0.39 cm{sup 3} in 3-BP 0, 5, 10 mg/kg, respectively: p=0.047). The percentage of TUNEL staining-positive cells was significantly increased in 3-BP-treated mice (0.53 vs. 1.40 vs. 1.84% in 3-BP 0, 5, 10 mg/kg, respectively; p=0.018). On Tc-99m-HYNIC annexin V imaging, tumor-to-background uptake ratio (UR) was 1.92 at one day and 4.23 at three days after 3-BP treatment of 5 mg/kg (non-treated tumor showed UR of 2.93). Apoptosis-inducing anti-tumor effect of 3-BP was able to be demonstrated in in vivo model of HCC by apoptotic in vivo imaging using Tc-99m-HYNIC annexin V.

  15. Differential Findings of Tc 99m Sestamibi Dual Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, Miju; Choi, Joon Young; Chung, Jae Hoon; Lee, Ji Young; Cho, Sook Kyung; Yoo, Jang; Park, Soo Bin; Lee, Kyung Han; Kim, Byung Tae [Sungkyunkwan, Univ. School of Medicine, Seoul (Korea, Republic of)

    2011-12-15

    This study aimed to investigate the differential findings in clinical and biochemical features, and Tc 99m sestamibi (MIBI) dual phase parathyroid lesions in patients with primary hyperparathyroidism. Subjects were 102 parathyroid lesions from 91 patients with primary hyperparathyroidism. Scintigraphic findings included radioactivity grade, uptake pattern, uptake contour lesion size on early and delayed images, and degree of washout. Clinical and biochemical features were also evaluated. Histopathology confirmed the final diagnosis for all the patients. Final diagnoses were 94 benign parathyroid lesions and 8 parathyroid carcinomas. The patients with parathyroid carcinoma were significantly older (p=0.002) and had significantly higher serum parathyroid hormone concentrations than those with benign parathyroid lesions (p<0.001). All malignant parathyroid lesions showed intense radioactivity similar to or greater than the submandibular gland activity on delayed images (p=0.007), and little radioactivity difference between early and delayed images (p=0.012). The cancer incidence for parathyroid lesions with both intense radioactivity and no washout was 17.0% (8/47). When parathyroid lesions with all of the above mentioned findings were regarded as malignant, the cancer incidence significantly increased from 17.0% to 33.3% (8/24, p<0.001). For Tc 99m MIBI dual phase parathyroid scintigraphy, uptake grade on delayed images and washout were significantly useful diagnostic criteria for differentiating benign from malignant parathyroid lesions, along with age and parathyroid hormone serum concentration.

  16. Tc-99 m diethylenetriamine-pentaacetic acid (DTPA): is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?

    Science.gov (United States)

    Amin, Amr; Effat, Dina; Goher, Nabila; Ramadan, Basma

    2013-12-01

    Methotrexate (MTX) is commonly employed as the initial DMARD used for the treatment of rheumatoid arthritis (RA). We aimed to contribute to the safety profile of MTX by assessing its cumulative effect on renal filtration. A total of 52 RA adult female patients with normal baseline serum creatinine and GFR at the initial diagnosis of the disease were included. Group 1 (G1) included 30 patients (mean age 40.4 ± 4.4 years) on MTX and NSAIDS, while 22 RA patients (mean age 38.5 ± 8.2 years) who received NSAIDs only served as control group (G2). Renal function was assessed by GFR measurement using technetium diethylenetriamine-pentaacetic acid (Tc-99 m DTPA) at a point of the study time corresponding to disease duration. Twenty-one out of thirty (70 %) in G1 showed reduced GFR compared to 6/22 (27.3 %) in G2 (P = 0.007), with 3.3 ± 0.5 % annual reduction in GFR. Reduced GFR in G1 showed significant negative correlation with age (r = -0.396, P = 0.005), MTX cumulative dose (r = -0.263, P = 0.049), MTX-intake duration (r = -0.293, P = 0.031) and NSAIDs-intake duration (r = -0.344, P = 0.014). Low-dose MTX has a slow cumulative effect on renal filtration manifested by GFR reduction overtime that could be monitored by Tc-99 m DTPA.

  17. Evaluation of ethinylestradiol effect on labelling red blood cells with Tc-99m; Avaliacao do efeito do etinilestradiol sobre a marcacao de hemacias com tecnecio-99m

    Energy Technology Data Exchange (ETDEWEB)

    Braga, A.C.S.; Oliveira, J.F.; Santos, J.S.; Oliveira, M.B.N.; Gutfilen, B.; Bernardo-Filho, Mario [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Inst. de Biologia Roberto Alcantara Gomes. Dept. de Biofisica e Biometria

    1999-11-01

    Significant alterations on the radiopharmaceutical distribution in humans are caused by drug interactions. The labeling red blood cells with technetium-99m is a daily routine procedure in nuclear medicine. Here, we investigated if the ethinylestradiol, an oral contraceptive, could alter the labeling of RBC with Tc-99m. Samples of blood with acid citrate dextrose were incubated with ethynilestradiol. Then, different concentrations of Sn C L{sub 2} were added and, after that, Tc-99m was added. Samples were centrifuged and plasma (P) and cells (C) were separated. the results showed that the drug studied decreased the uptake of radioactivity (%ATI) in the C to the reducing agent in the concentration of 1.2 (from 92.3 to 78.0) and increased in 12.0 (18.8 to 36.0) and in 24.0 (22.8 to 32.0){mu}/ml of Sn C L{sub 2}. The obtained results can be explained by the fact that this drug could alter the membrane permeability to the transport of stannous and/or pertechnetate ions. (author) 18 refs., 2 tabs.

  18. An incidentally found inflamed uterine myoma Causing low abdominal pain, using TC-99m-tektrotyd single photon emission computed tomography-CT hybrid imaging

    Energy Technology Data Exchange (ETDEWEB)

    Zandieh, Shahin; Schuetz, Matthias; Bernt, Reinhard; Zwerina, Jochen; Haller, Joerg [Hanusch-Hospital, Teaching Hospital of Medical University of Vienna, Vienna (Australia)

    2013-10-15

    We report the case of a 50-year-old woman presented with a history of right hemicolectomy due to an ileocecal neuroendocrine tumor and left breast metastasis. Owing to a slightly elevated chromogranin A-level and lower abdominal pain, single photon emission computed tomography-computer tomography (SPECT-CT) was performed. There were no signs of recurrence on the SPECT-CT scan, but the patient was incidentally found to have an inflamed intramural myoma. We believe that the slightly elevated chromogranin A-level was caused by the hypertension that the patient presented. In the clinical context, this is a report of an inflamed uterine myoma seen as a false positive result detected by TC-99m-Tc-EDDA/HYNIC-Tyr3-Octreotide (Tektrotyd) SPECT-CT hybrid imaging.

  19. [Radioisotopic quantification of kidney function using Tc-99m-DMSA. Comparison with creatinine clearance in children with a single kidney].

    Science.gov (United States)

    Baillet, G; Gagnadoux, M F; Mathonnat, F; de Vernejoul, P; Broyer, M

    1986-01-01

    To assess the accuracy of renal function quantification with Tc 99m-DMSA in children, we compared DMSA renal uptake and creatinine clearance in 16 cases of children with single kidney. The age of the patients ranged from two month to fourteen years. DMSA renal uptake was measured 7 hours after injection and was normalized in percent of the injected activity. A significant correlation was found between creatinine clearance and DMSA uptake (Pearson's r = 0.866, p less than 0.01). Normal creatinine clearance in children (80 to 120 ml/min-1 X 1.73 m-2) allowed determination of normal renal uptake (36 to 60%). This study indicates that in cases of asymmetrical renal impairment renal uptake reflects split renal creatinine clearance. Since the former is much easier to measure, DMSA should play an important role in the evaluation of differential renal function.

  20. Detection of platelet deposition in cases of arteriosclerosis obliterans (ASO) using indium-111 platelets and Tc-99m human serum albumin

    Energy Technology Data Exchange (ETDEWEB)

    Kitagawa, Kazuo; Miyai, Motonobu; Etani, Hideki

    1987-02-01

    We evaluated platelet deposition in vivo in 10 patients with arteriosclerosis obliterans (ASO) of the lower limbs and 8 normal subjects with a dual-tracer technique using indium-111 platelets and Tc-99m human serum albumin. Each patient with ASO showed intermittent claudication and angiographically occlusive vascular lesions in either the aorta, common iliac artery, external iliac artery, internal iliac artery or femoral artery. Of the 8 patients who were not under antiplatelet medication, 5 showed positive platelet deposition at angiographically occlusive vascular sites, whereas none of the normal subjects showed in vivo platelet deposition. In three patients who showed platelet deposition without antiplatelet medication and thereafter received aspirin therapy (650 mg/day), platelet deposition at all occlusive vascular sites was resolved after aspirin therapy. This preliminary study indicated that platelet scintigraphy might be useful in evaluating thrombogenicity and the effect of antiplatelet medication in vivo, in patients with ASO.

  1. Acute effect of electroconvulsive therapy on brain perfusion assessed by Tc99m-hexamethylpropyleneamineoxim and single photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Bajc, M.; Basic, M.; Topuzovic, N.; Babic, D.; Ivancevic, D. (Department of Nuclear Medicine, University Hospital Rebro, Zagreb (Yugoslavia)); Medved, V. (Psychiatric Clinic, University Hospital Rebro, Zagreb (Yugoslavia))

    1989-01-01

    Regional cerebral blood flow (rCBF) was measured in relative terms with Tc99m-hexamethylpropyleneamineoxim and single photon emission computed tomography in 11 patients undergoing electroconvulsive therapy (ECT). The patients suffered from major depressive disorder (n=8) or schizoaffective disorders (n=3). rCBF was measured under general anesthesia 3 days prior to the ECT treatment and coinciding with the ECT stimualtion. ECT caused a redistribution of the tracers uptake. The uptake became more pronounced in frontal parts of the brain and in the basal ganglia than in posterior parts of the cortex, and the thalamus. This selective effect of ECT on rCBF may be related to catecholaminergic projections to anterior parts of the brain. (author).

  2. Nude mice multi-drug resistance model of orthotopic transplantation of liver neoplasm and Tc-99m MIBI SPECT on p-glycoprotein

    Institute of Scientific and Technical Information of China (English)

    Yu Han; Xiao-Ping Chen; Zhi-Yong Huang; Hong Zhu

    2005-01-01

    AIM: To establish a model of drug-resistant neoplasms using a nude mice model, orthotopic transplantation of liver neoplasm and sporadic abdominal chemotherapy.METHODS: Hepatocellular carcinoma cells HepG2 were cultured and injected subdermally to form the tumorsupplying mice. The orthotopic drug-resistant tumors were formed by implanting the tumor bits under the envelope of the mice liver and induced by abdominal chemotherapy with Pharmorubicin. Physical examination, ultrasonography, spiral CT and visual inspection were used to examine tumor progression. RT-PCR and immunohistochemistry wereused to detect expression of mdr1 mRNA and its encodedprotein p-glycoprotein (p-gp). Tc-99m sestamibi scintigraphy was performed by obtaining planar abdominal images at 20 min after injection, and the liver/heart ratios werecalculated.RESULTS: Post-implantation mortality was 0% (0/25),tumor implantation success was 90% (22/25), and the rate of implanting successfully for the second time was 100% (3/3). Tumor induction using Pharmorubicin was 80% (16/20). The mdr1 mRNA expression of the induced group was 23 times higher than that of the control group, and p-gp protein expression was 13-fold higher compared to the control group. The liver/heart ratio (as assessed in vivo, using Tc-99m radiography) was decreased significantly in the induced group as compared to the control group. CONCLUSION: We have established an in vivo model of mdr1 in nude mice by orthotopic transplantation of liver neoplasm coupled to chemotherapy. We propose that identification of drug resistance as characterized by decreased 99mTc-ppm radiography due to enhanced clearance by p-gp may be useful in detecting in vivo drug resistance, as well as a useful tool in designing more effective therapies.

  3. Differences of Tc-99m HMPAO SPECT imaging in the early stage of subcortical vascular dementia compared with Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Won; Kang, Do Young; Park, Min Jeong; Cheon, Sang Myung; Cha, Jae Kwan; Kim, Sang Ho; Kim, Jae Woo [College of Medicine, Dong-A University, Busan (Korea, Republic of)

    2007-12-15

    The aim of this study is to assess the specific patterns of regional cerebral blood flow (rCBF) in patients with the early stage of subcortical vascular dementia (SVaD) and Alzheimer's disease (AD) using Tc-99m HMPAO SPECT, and to compare the differences between the two conditions. Sixteen SVaD, 46 AD and 12 control subjects participated in this study. We included the patients with SVaD and AD according to NINCDS-ADRDA and NINDS-AIREN criteria. They were all matched for age, education and clinical dementia rating scores. Three groups were evaluated by Tc-99m HMPAO SPECT using statistical parametric mapping (SPM) for measuring rCBF. The SPECT data of patients with SVaD and AD were compared with those of normal control subjects and then compared with each other. SPM analysis of the SPECT image showed significant perfusion deficits on the right temporal region and thalamus, left insula and superior temporal gyrus, both cingulate gyri and frontal subgyri in patients with SVaD and on the left supramarginal gyrus, superior temporal gyrus, postcentral gyrus and inferior parietal lobule, right fugiform gyrus and both cingulate gyri in AD compared with control subjects (uncorrected {rho} < 0.01). SVaD patients revealed significant hypoperfusion in the right parahippocampal gyrus with cingulated gyrus, left insula and both frontal subgyral regions compared with AD (uncorrected {rho} < 0.01). Our study shows characteristic and different pattern of perfusion deficits in patients with SVaD and AD, and these results may be helpful to discriminate the two conditions in the early stage of illness.

  4. In vivo click reaction between Tc-99m-labeled azadibenzocyclooctyne-MAMA and 2-nitroimidazole-azide for tumor hypoxia targeting.

    Science.gov (United States)

    Sun, Wenjing; Chu, Taiwei

    2015-10-15

    The bioactivity of nitroimidazole in Tc-99m-labeled 2-nitroimidazole, a traditional solid tumor hypoxia-imaging agent for single photon emission computed tomography (SPECT), is reduced by the presence of large ligand and metallic radionuclide, exhibiting lower tumor-to-nontumor ratios. In an effort to solve this general problem, a pretargeting strategy based on click chemistry (strain-promoted cyclooctyne-azide cycloaddition) was applied. The functional click synthons were synthesized as pretargeting components: an azide group linked to 2-nitroimidazole (2NIM-Az) serves for tumor hypoxia-targeting and azadibenzocyclooctyne conjugated with monoamine monoamide dithiol ligand (AM) functions as radiolabeling and binding group to azides in vivo. 2NIM-triazole-MAMA was obtained from in vitro click reaction with a reaction rate constant of 0.98M(-1)s(-1). AM and 2NIM-triazole-MAMA were radiolabeled with Tc-99m. The hypoxia-pretargeting biodistribution was studied in Kunming mice bearing S180 tumor; (99m)Tc-AM and (99m)Tc-triazole-2NIM were used as blank control and conventional control. Compared to the control groups, the pretargeting experiment exhibits the best radio-uptake and retention in tumor, with higher tumor-to-muscle and tumor-to-blood ratios (up to 8.55 and 1.44 at 8h post-(99m)Tc-complex-injection, respectively). To some extent, the pretargeting strategy protects the bioactivity of nitroimidazole and therefore provides an innovative approach for the development of tumor hypoxia-SPECT imaging agents. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Are there any differences in uptake of Tc-99m MIBI and tetrofosmin between cancer cells expressing P-glycoprotein and MDR-related protein?

    Energy Technology Data Exchange (ETDEWEB)

    Seo, J. H.; Yoo, J. A.; Seo, M. R.; Bae, J. H.; Jeong, S. Y.; Ahn, B. C.; Lee, K. B.; Lee, J [Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2004-07-01

    Uptake of Tc-99m MIBI and Tc-99m tetrofosmin(TF) in two multidrug resistance cells, human colon cancer HCT/CLO2 cells expressing P-glycoprotein(Pgp) and non-small cell lung cancer A549 cells showing multidrug-resistance related protein(MRP) in vivo. RT-PCR Western blot analysis and immunohistochemistry(IHC) were used to detect Pgp and MRP. Cellular uptake of MIBI and TF was measured with single cell suspension of HCR/CLO2 and 549 cells. Cells were inoculated in flanks of 24 nude mice. Group 1 (Gr1) and Gr3 mice were injected with only MIBI or TF, and Gr2 and Gr4 mice were treated with cyclosporin A(CsA) before injection of MIBI or TF. Mice were sacrificed at 10, 60 and 240-min after tracer injection. Radioactivities of organs and tumors were measured. 549 cells expressed MRPr1 protein detected by Western blot and IHC staining of tumor tissue at cell membrane but not Pgp, A549/CLO2 was vice versa. Cellular uptake and % increases with CsA were higher for MIBI than TF for both cells in vitro. Animal studies showed that MIBI and TF uptake were progressively increased by time in both Pgp(+) HCT/CLO2 tumor and MRP(+) A549 cells in both Gr1 and Gr3. There were no significant differences in tumoral uptake of MIBI and TF between Grl and Gr3 for both cells except higher MIBI uptake in Pgp cells at 60-min. % increases of MIBI (111% at 10 min, 220% at 60 min, 426% at 240 min) and TF uptake (186% at 10 min 579% at 60 min, 390% at 240 min) were progressively increased with time up to 240-min with CsA % increases of MIBI (114% at 10 min, 257% at 60 min 396% at 240 min) and TF uptake (110% at 10 min, 205% at 60 min, 410% at 240 min) were similar with those in HCT/CLO2 tumor. There were no differences in MIBI and TF uptake between Pgp and MRP tumors. Although MIBI showed better MDR reversal effect of modulator CsA than TF in vitro, there were no differences for both tumors in vivo. MIBI and TF are suitable tracers for imaging Pgp and MRP-mediated drug resistance in cancers.

  6. Evaluation of Serumal Levels of AST, ALT, Total Bilirubin, Glucose, Urea and Creatinin in Mice after Administration of Tc-99m MIBI

    Directory of Open Access Journals (Sweden)

    Bahram Amouoghli Tabrizi

    2012-02-01

    Full Text Available Tc-99m MIBI methoxyisobutylisonitrile (MIBI is a lipophilic cationic agent which is widely used for myocardial perfusion imaging and also for the detection of various tumors. In present study, for evaluation of serum level of AST, ALT, Total bilirubin, FBC, Urea and Creatinin, 25 mice, respectively were selected and they were divided in 5 groups. 0.3 mC/kg of drug was injected to 4 groups via tail vein. In the control group, before beginning of the investigation bleeding was done. Twenty four hours after injection from the 2nd group, 48 h later from the 3rd group, one week later from the 4th group and two weeks later from the 5th group bleeding was done respectively and the levels of Glucose, Urea, creatinin, ALT, AST and T-bilirubin, respectively were measured using spectophotometr (Biowave S2100 made in England and diagnostic kits (made in bio-chemistry company, Iran. In Comparison to control group, results had significant differences in serum level of Urea, Creatinin and total bilirubin after 24 and 48 h of administration(p<0.05. Also there were insignificant differences in serum ALT and AST level and Glucose after 24 h of administration in all groups (p<0.05. Results shows that more care is needed for administration of drug in diabetic, renal and hepatic patients.

  7. Distribution of lung blood on modified bilateral Glenn shunt evaluated by Tc-99m-MAA lung perfusion scintigraphy: A retrospective study.

    Science.gov (United States)

    Si, Biao; Luan, Zhao-Sheng; Wang, Tong-Jian; Ning, Yan-Song; Li, Na; Zhu, Meng; Liu, Zhong-Min; Ding, Guang-Hong; Qiao, Bin

    2016-09-01

    The aim of the present study was to determine the distribution of lung blood in a modified bilateral Glenn procedure designed in our institute with lung perfusion scintigraphy. Sixteen consecutive patients who underwent modified bilateral Glenn operation from 2011 to 2014 were enrolled in the study. The control group consisted of 7 patients who underwent bidirectional Glenn shunt. Radionuclide lung perfusion scintigraphy was performed using Tc-99m-macro aggregated albumin (MAA) in all patients. For the patients in modified bilateral Glenn group, the time at which the radioactivity accumulation peaked did not differ significantly between the right and left lung field (t = 0.608, P = 0.554). The incidence of perfusion abnormality in each lung lobe also did not differ significantly (P = 0.426 by Fisher exact test). The radioactive counts were higher in the right lung than in the left lung, but the difference was not statistically significant (t = 1.502, P = 0.157). Radioactive perfusion in the lower lung field was significantly greater than that in the upper field (t = 4.368, P lung to that in left lung was significantly lower in the modified bilateral Glenn group (t = 3.686, P = 0.002). Lung perfusion scintigraphy confirmed the benefit of the modified bilateral Glenn shunt with regard to more balanced blood perfusion in both lungs.

  8. Additional Value of SPECT/CT to Tc-99m MAG3 Renal Scintigraphy in the Diagnosis of a Patient with Ureteroileal Fistula

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    Nilüfer Yıldırım Poyraz

    2012-08-01

    Full Text Available We performed Tc-99m MAG3 dynamic renal scintigraphy followed by a SPECT/CT imaging to a 38-yr-old woman who had a fistula in the lower urinary tract after a gynecological operation for diagnostic purposes. After scintigraphy, CT and fusion images were evaluated, it was observed that the activity in the right lower quadrant was actually in the ileal lumen. When early and late SPECT/CT images were compared, it was seen that the activity was moving distally with intestinal peristaltism. The reason for diagnostic imaging of the fistulas is not only to show the existence of the fistula but also locate it anatomically before the surgery. SPECT systems integrated with CT scanning provide functional and anatomical imaging at the same session. Dynamic renal scintigraphy and abdominal SPECT/CT, is a safe diagnostic procedure in visualization of urinary tract fistulas with advantages of the low cost, low radiation exposure and easier tolerability compared to double contrast imaging. (MIRT 2012;21:84-87

  9. Motor cortex stimulation(MCS) for intractable complex regional pain syndrome (CRPS) type II: PSM analysis of Tc-99m ECD brain perfusion SPECT

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    Chung, Y. A.; Son, B. C.; Yoo, I. R.; Kim, S. H.; Kim, E. N.; Park, Y. H.; Lee, S. Y.; Sohn, H. S.; Chung, S. K. [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2001-07-01

    We had experienced a patient with intractable CRPS in whom statistical parametric mapping (SPM) analysis of cerebral perfusion explained the mechanism of pain control by MCS. A 43-year-old man presented spontaneous severe burning pain in his left hand and forearm and allodynia over the left arm and left hemibody. After the electrodes for neuromodulation therapy were inserted in the central sulcus, the baseline and stimulation brain perfusion SPECT using Tc-99m ECD were obtained within two days. The differences between the baseline and stimulation SPECT images, estimated at every voxel using t-statistics using SPM-99 software, were considered significant at a threshold of uncorrected P values less than 0.01. Among several areas significantly activated following pain relief with MCS, ipsilateral pyramidal tract in the cerebral peduncle might be related to the mechanism of pain control with MCS through efferent motor pathway. The result suggested that corticospinal neurons themselves or motor cortex efferent pathway maintained by the presence of intact corticospinal neurons could play an important role in producing pain control after MCS. This study would helpful in understanding of neurophysiology.

  10. Assessing Response Using Tc99m-MIBI Early after Interstitial Chemotherapy with Carmustine-Loaded Polymers in Glioblastoma Multiforme: Preliminary Results

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    D. Cecchin

    2014-01-01

    Full Text Available Introduction. Early signs of response after applying wafers of carmustine-loaded polymers (gliadel are difficult to assess with imaging because of time-related imaging changes. Tc99m-sestamibi (MIBI brain single-photon emission tomography (SPET has reportedly been used to reveal areas of cellularity distinguishing recurrent neoplasm from radionecrosis. Our aim was to explore the role of MIBI SPET in assessing response soon after gliadel application in glioblastoma multiforme (GBM. Methods. We retrospectively reviewed the charts on 28 consecutive patients with a radiological diagnosis of GBM who underwent MIBI SPET/CT before surgery (with intracavitary gliadel placement in 17 patients, soon after surgery, and at 4 months. The area of uptake was selected using a volume of interest that was then mirrored contralaterally to obtain a semiquantitative ratio. Results. After adjusting for ratio at the baseline, the effect of treatment (gliadel versus non-gliadel was not statistically significant. Soon after surgery, however, 100% of patients treated with gliadel had a decreased ratio, as opposed to 62.5% of patients in the non-gliadel group P=0.0316. The difference between ratios of patients with radical versus partial resection reached statistical significance by a small margin P=0.0528. Conclusions. These data seem to suggest that the MIBI ratio could be a valuable tool for monitoring the effect of gliadel early after surgery.

  11. Tc-99m-BrIDA hepatobiliary (HIDA) scan has a low sensitivity for detecting biliary complications after orthotopic liver transplantation in patients with hyperbilirubinemia.

    Science.gov (United States)

    Hopkins, L Olivia; Feyssa, Eyob; Parsikia, Afshin; Khanmoradi, Kamran; Zaki, Radi; Campos, Stalin; Araya, Victor; Tran, Huyen; Ortiz, Jorge

    2011-12-01

    Tc-99m-BrIDA hepatobiliary scans are noninvasive tests for detecting biliary leaks and obstructions. However, there is low sensitivity and specificity in patients with hyperbilirubinemia. Biliary complications (BC) are the Achilles heel of orthotopic liver transplantation (OLT). We questioned whether hyperbilirubinemia in liver transplant recipients rendered HIDA scanning less dependable. HIDA findings were compared to endoscopic retrograde cholangiopancreatography, laparotomy, and clinical course. Results were categorized as follows: true positive (TP), true negative (TN), false positive (FP), false negative (FN), or nondiagnostic/inconclusive. We searched for variables associated with erroneous or nondiagnostic tests which we defined as all examinations determined to be FP, FN and/or nondiagnostic/inconclusive. Thirty-four patients underwent a HIDA scan. The sensitivity and specificity were 70 and 100%. The sensitivity of HIDA improved to 100% in patients with a total bilirubin (TB) 5 mg/dl. One FN had a TB <5 mg/dl, but was determined inconclusive due to the roux-en-Y. HIDA scans performed when the total bilirubin was <5 mg/dl had a high sensitivity and specificity for detecting biliary complications after OLT. However, when the total bilirubin exceeded 5 mg/dl, the specificity was still 100% but the numbers of nondiagnostic/inconclusive and FN exams were increased.

  12. The role of Tc-99m HMPAO brain perfusion SPECT in the psychiatric disability evaluation of patients with chronic traumatic brain injury

    Energy Technology Data Exchange (ETDEWEB)

    So, Young [Nuclear Medicne, Seoul National Univ., Seoul (Korea, Republic of); Lee, Kang Wook; Lee, Sun Woo; Ghi, Lek Sung; Song, Chang June [College of Medicine, Chungnam National Univ., Taejon (Korea, Republic of)

    2002-08-01

    We studied whether brain perfusion SPECT is useful in the psychiatric disability evaluation of patients with chronic traumatic brain injury (TBI). Sixty-nine patients (M:F=58:11, age 39 {+-} 14 years) who underwent Tc-99m HMPAO brain SPECT, brain MRI and neuropsychological (NP) tests during hospitalization in psychiatric wards for the psychiatric disability evaluation were included; the severity of injury was mild in 31, moderate in 17 and severe in 21. SPECT, MRI, NP tests were performed 6 {approx} 61 months (mean 23 months) post-injury. Diagnostic accuracy of SPECT and MRI to show hypoperfusion or abnormal signal intensity in patients with cognitive impairment represented by NP test results were compared. Forty-two patients were considered to have cognitive impairment on NP tests and 27 not. Brain SPECT showed 71% sensitivity and 85% specificity, while brain MRI showed 62% sensitivity and 93% specificity (p>0.05, McNemar test). SPECT found more cortical lesions and MRI was superior in detecting white matter lesions. sensitivity and specificity of 31 mild TBI patients were 45%, 90% for SPECT and 27%, 100% for MRI (p>0.05, McNemar test). Among 41 patients with normal brain MRI, SEPCT showed 63% sensitivity (50% for mild TBI) and 88% specificity (85% for malingerers). Brain SPECT has a supplementary role to neuropsychological tests in the psychiatric disability evaluation of chronic TBI patients by detecting more cortical lesions than MRI.

  13. Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using Tc99m-TRODAT-1 SPECT

    Directory of Open Access Journals (Sweden)

    Tang-Kai Yin

    2014-01-01

    Full Text Available This study was to investigate whether various region-of-interest (ROI methods for measuring dopamine transporter (DAT availabilities by single photon emission computed tomography (SPECT are statistically different, whether results of medical research are thereby influenced, and causes of these differences. Eighty-four healthy adults with Tc99m-TRODAT-1 SPECT and magnetic resonance imaging (MRI scans were included. Six major analysis approaches were compared: (1 ROI drawn on the coregistered MRI; (2 ROIs drawn on the SPECT images; (3 standard ROI templates; (4 threshold-ROIs; (5 atlas-based mappings with coregistered MRI; and (6 atlas-based mappings with SPECT images. Using the atlas-based approaches we assessed the influence of striatum ROIs by slice-wise and voxel-wise comparisons. In (5 and (6, three partial-volume correction (PVC methods were also explored. The results showed that DAT availabilities obtained from different methods were closely related but quite different and leaded to significant differences in determining the declines of DAT availability per decade (range: 5.95–11.99%. Use of 3D whole-striatum or more transverse slices could avoid biases in measuring the striatal DAT declines per decade. Atlas-based methods with PVC may be the preferable methods for medical research.

  14. Evaluation of surgical outcome with pre-and post-operative rest/acetazolamide Tc-99m HMPAO SPECT in children with moyamoya disease

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. S.; Wang, K. C.; Cho, B. K.; Chung, J. K.; Lee, M. C. [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of); Hyun, I. Y. [College of Medicine, Inha Univ., Inchon (Korea, Republic of)

    1998-08-01

    This study was performed to evaluate the outcome of encephalo-duro-arterio-synangiosis(EDAS) surgery with rest/acetazolamide Tc-99m HMPAO SPECT in moyamoya disease. Rest/acetazolamide subtraction SPECT with consecutive acquisition were done before and 2 months after 21 EDAS surgeries in 18 patients. Perfusion decrease was graded visually for 14 areas of each hemisphere as 0 (normal) to 3 (defect) using 4 point scoring system. Postopertive rest perfusion or perfusion reserve was compared with preoperative ones. Among 294 areas of 21 hemispheres, rest perfusion abnormality was found in 97 areas of 15 hemispheres. Decrease of perfusion reserve was found in 146 areas of 18 hemispheres. Six hemispheres having normal rest perfusion and 12 of 15 hemispheres having rest perfusion abnormality showed reserve decrease. Three having rest perfusion defect did not change after acetazolamide in preoperative SPECT. After operation, 16 patients (89%) demonstrated clinical improvement. Fifteen among 18 hemispheres (83%) with decreased reserve improved. Rest perfusion abnormality improved in 6 among the 15 hemispheres (40%). The areas having rest perfusion and/or reserve decrease improved in 87 among 146 areas (60%). Decrease of reserve improved in 85% (68/80). However, areas without reserve decrease also improved in 29% (19/66). The better was preoperative rest perfusion in involved areas or the more decreased vascular reserve, the more improved perfusion and reserve after operation. We conclude that assessment of perfusion and perfusion reserve using rest/acetazolamide brain perfusion SPECT predict the surgical outcome in patients with moyamoya disease.

  15. Surgical management of primary hyperparathyroidism guided by double-phase Tc-99m-MIBI scintigraphy%Tc-99m-MIBI双时相显像在原发性甲状旁腺功能亢进症手术治疗中的价值

    Institute of Scientific and Technical Information of China (English)

    Abdel Hamid Hussein Ezzat; Tarek El. Baradie; Amr Attia; Magdy Kotb; Ahmad Zaher; Iman Gouda

    2012-01-01

    Objective: The aim of this work was to study the clinicopathological features of cases with primary hyperparathyroidism (PHPT) referred to National Cancer Institute (NCI), Cairo University in the last six years and to study the role of nuclear medicine techniques in the initial diagnosis and preoperative localization directing surgical management of these cases. Methods: This study included 27 patients with PHPT properly diagnosed and treated in the NCI, Cairo University from January 2005 to December 2010. Preoperative neck U/S and Tc-99m-MIBI scintigraphy were done in all cases. If preoperative localization detected a single lesion, unilateral exploration was done. Bilateral exploration was done if multiple foci of active parathyroid glands or no lesions were detected. Results: This study included 27 patients (8 males and 19 females). The median age was 43 years (range from 19 to 68 years). All cases presented with bone disease in the form of bony pain in 23 patients, bony swellings in 15 patients and pathological fractures in 6 cases. Twenty one patients (77.8%) had single adenoma, 5 cases (18.5%) had parathyroid hyperplasia, and only one case had double adenomas. The sensitivity of neck U/S in detecting single adenoma was 61.9% (13/21), with 81% positive predictive value (PPV) while the sensitivity of Tc-99m- MIBI scintigraphy was 90.5% (19/21) with 100% PPV. Based on preoperative localization tests, unilateral exploration was done in 19 patients with solitary adenomas. All cases in this group were cured with no reported case of persistent or recurrent hypercalcemia. Conclusion: Presentation of PHPT may mimic malignant bone tumors but fortunately these patients were correctly diagnosed with bone scan which confirm the presence of metabolic bone disease rather than bone metastases. This was followed by estimation of serum calcium and parathormone levels for confirmation. Unilateral exploration based on the combination of ultrasound and preoperative localization

  16. Relevance of Tc-99m-HYNIC-tir-octreotide scintigraphy in a patient affected by sarcoidosis with lung and joints involvement and secondary Sjogren's syndrome treated with infliximab : Case report

    NARCIS (Netherlands)

    Migliore, A.; Signore, A.; Capuano, A.; Bizzi, E.; Massafra, U.; Vacca, F.; Todino, V.; Chianello, M.

    2008-01-01

    We report the case of a 59 years old woman affected by lung and joint sarcoidosis, secondary Sjogren's syndrome refractory to common disease-modifying antirheumatic drugs (DMARDs) that regressed with infliximab and methotrexate. Tc-99m-HYNIC- TOC scintigraphy was useful in diagnosis, choice of

  17. Tc-99m ECD brain SPECT in patients with traumatic brain injury: evaluating distribution of hypoperfusion and assessment of cognitive and behavioral impairment in relation to thalamic hypoperfusion

    Energy Technology Data Exchange (ETDEWEB)

    Park, Soon Ah; Lim, Seok Tae; Sohn, Myung Hee [College of Medicine, Chonbuk National Univ., Chonju (Korea, Republic of)

    2000-12-01

    We evaluated the distribution of hypoperfusion in patients with traumatic brain injury (TBI) and the relationship of thalamic hypoperfusion to severity of cognitive and behavioral sequelae. Tc-99m ECD SPECT and MRI were performed in 103 patients (M/F=81/22, mean age 34.7{+-} 15.4 yrs) from 0.5 to 55 months (mean 10.3 months) after TBI. The patients were divided into three groups showing no abnormalities (G1), focal (G2) and diffuse injury (G3) on MRI. Psychometric tests assessed 11 cognitive or behavioral items. In all patients, we evaluated the distribution of hypoperfused areas in SPECT, and in 57/103 patients, neuropsychological (NP) abnormalities in patients with thalamic hypoperfusion were compared with those of patients without thalamic hypoperfusion. The perfusion dificits were most frequently located in the frontal lobe (G1, 42.3%: G2 34.5%: G3 33.3%), temporal lobe (24{approx}26%) thalami (21{approx}22.4%), parietal and occipital lobe ({<=}10%). Numbers of NP abnormalities in the cases of cortical hypoperfusion with or without concomitant thalamic hypoperfusion were following: the former 4.7{+-}1.5 and the latter 3.2{+-}1.4 in G1, 5.0{+-}1.1 and 4.8{+-}1.2 in G2, 6.8{+-}1.8 and 6.3{+-}1.1 in G3, respectively. This difference according to thalamic hypoperfusion was significant in G1 (p=0.002), but was not significant in G2 or G3. SPECT in patients with TBI had demonstrated hypoperfusion mostly involving the frontal, temporal and thalami. In normal group on MRI, frontal hypoperfusion was more prominent than that of any other group, Furthermore in this group, SPECT could predict severity of NP outcome by concomitant thalamic hypoperfusion with cerebral cortical abnormalities.

  18. The Agreement Between Blood Pool - Delayed Bone Scintigraphy and Tc-99m Human Immunoglobulin G (HIG Scintigraphy in the Determination of the Presence and Severity of Inflammatory Arthritis

    Directory of Open Access Journals (Sweden)

    Gulizar Kacar

    2011-08-01

    Full Text Available Objective: In this study, it was aimed to investigate the agreement between early phase of bone scintigraphy – human immunoglobulin scintigraphy (EPBS-HIG and late phase bone scintigraphy – HIG (LPBS-HIG in the determination of the presence and also the severity of inflammatory arthritis. Material and Methods: Twenty-eight patients (23 female, 5 male; between 19 to 80 years of age with inflammatory arthritis were included in the study. Tc-99m HIG and blood pool/late phase bone scintigraphies were performed in all patients. In scintigraphic examinations, the joints were scored with the degree of accumulation of the radiopharmaceutical by the semiquantitative analysis (0=Background activity, 1=Faint uptake, 2=Moderate uptake, 3=Marked uptake which is called as visually active joint score as severity index of the disease. To estimate the agreement between EPBS – HIG and LPBS - HIG in the determination of the presence and severity of inflammatory arthritis, 2x2 kappa coefficients were calculated. Results: Our results showed good agreement between EPBS - HIG for the presence of inflammation (kappa: 0.72 but not for the severity of the disease (kappa: 0.29, poor agreement between LPBS - HIG for both the presence (kappa: 0.51 and severity (kappa: 0.01 of inflammatory arthritis. Conclusion: The blood pool scintigraphy could be used in the investigation of the presence of inflammatory arthritis because the good agreement with HIG and the lower cost but not for the severity of the disease. (MIRT 2011;20:45-51

  19. Effect of acupuncture on regional cerebral blood flow at acupoints GV 20, GV. 26, LI, 4. ST. 36, SP. 6 evaluated by Tc-99m ECD brain SPECT

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    Song, Ho Chun; Bom, Hee Seung; Kang, Hwa Jeong; Kim, Seong Min; Jeong, Hwan Jeong; Kim, Ji Yeul [College of Medicine, Dongshin Univ., Naju (Korea, Republic of); Ahn, Soo Gi [College of Medicine, Wonkwang Univ., Iksan (Korea, Republic of)

    2000-12-01

    To evaluate the effect of acupuncture on regional cerebral blood flow (rCBF) at acupoints suggested by oriental medicine to be related to the treatment of cerebrovascular diseases. Rest/acupuncture-stimulation Tc-99m ECD brain SPECT using a same-dose subtraction method was performed on 54 normal volunteers (34 males, 20 females, age range from 18 to 62 years) using six paradigms: acupuncture at acupoints GV. 20, GV. 26, LI. 4, ST. 36 and SP. 6. In the control study, needle location was chosen on a non-meridian focus 1 cm posterior to the right fibular head. All images were spatially normalized, and the differences between rest and acupuncture stimulation were statistically analyzed using SPM for Windows. Acupuncture applied at acupoint GV. 20 increased rCBF in both the anterior frontal lobes, the right frontotemporal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at GV. 26 increased rCBF in the left prefrontal cortex. Acupuncture at LI. 4 increased rCBF in the left prefrontal and both the inferior frontal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at ST. 36 increased rCBF in the left anterior temporal lobe, the right inferior frontal lobes, and the left cerebellum. Acupuncture at SP 6 increased rCBF in the left inferior frontal and anterior temporal lobes. In the control stimulation, no significant rCBF increase was observed. The results demonstrated a correlation between stimuation at each acupoint with increase in rCBF to the corresponding brain areas.

  20. Effective detection of the tumors causing osteomalacia using [Tc-99m]-HYNIC-octreotide (99mTc-HYNIC-TOC) whole body scan

    Energy Technology Data Exchange (ETDEWEB)

    Jing, Hongli, E-mail: annsmile1976@sina.com [Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Li, Fang, E-mail: lifang@pumch.cn [Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Zhuang, Hongming, E-mail: zhuang@email.chop.edu [Department of Radiology, The Children' s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 34th and Civic Ctr Blvd, Philadelphia, PA 19104 (United States); Wang, Zhenghua, E-mail: ccq1214@yahoo.com.cn [Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Tian, Jian, E-mail: tianjian4809@hotmail.com [Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Xing, Xiaoping, E-mail: xingxp@126.com [Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Jin, Jin, E-mail: jinjin9010@126.com [Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Zhong, Dingrong, E-mail: ZhongDR@pumch.cn [Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China); Zhang, Jingjing, E-mail: zhangjingjingtag@163.com [Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730 (China)

    2013-11-01

    Purpose: Tumor-induced osteomalacia (TIO) is an endocrine disorder caused by tumors producing excessive fibroblast growth factor-23 (FGF-23). The causative tumors are generally small, slow-growing benign mesenchymal tumors. The only cure of the disease depends on resection of the tumors, which are extremely difficult to localize due to their small sizes and rare locations. Since these tumors are known to express somatostatin receptors, this research was undertaken to evaluate efficacy of [Tc-99m]-HYNIC-octreotide (99mTc-HYNIC-TOC) whole body imaging in this clinical setting Methods: Images of 99mTc-HYNIC-TOC scans and clinical chart from 183 patients with hypophosphatemia and clinically suspected TIO were retrospectively reviewed. The scan findings were compared to the results of histopathological examinations and clinical follow-ups. Results: Among 183 patients, 72 were confirmed to have TIO while 103 patients were found to have other causes of hypophosphatemia. The possibility of TIO could not be either diagnosed or excluded in the remaining 8 patients. For analytical purposes, these 8 patients who could neither be diagnosed nor excluded as having TIO were regarded as having the disease, bringing the total of TIO patients to 80. The 99mTc-HYNIC-TOC scan identified 69 tumors in 80 patients with TIO, which rendered a sensitivity of 86.3% (69/80). 99mTc-HYNIC-TOC scintigraphy excluded 102 patients without TIO with a specificity of 99.1% (102/103). The overall accuracy of 99mTc-HYNIC-TOC whole body scan in the localization of tumors responsible for osteomalacia is 93.4% (171/183). Conclusions: Whole body 99mTc-HYNIC-TOC imaging is effective in the localization of occult tumors causing TIO.

  1. A new method to evaluate ischemic heart disease. Combined use of rest thallium-201 myocardial SPECT and Tc-99m exercise tetrofosmin first pass and myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong-ih; Goto, Hideki; Kobayashi, Katsuhiro; Sawada, Yoshihiro; Miyake, Yoshitaka; Fujiwara, Go [Nishiyodo Hospital, Osaka (Japan); Okada, Tomoya; Nishimura, Tsunehiko

    1999-06-01

    We developed a new diagnostic method for simultaneously evaluating myocardial ischemia, myocardial viability and ventricular function in less than 90 minutes by combined use of rest thallium-201 (Tl) SPECT and exercise Tc-99m tetrofosmin (TF) first pass and SPECT. The subjects were 9 healthy controls, 19 angina pectoris patients, and 19 old myocardial infarction patients, in all of whom coronary angiography had been performed. Rest Tl myocardial SPECT was performed first, and was followed by exercise TF myocardial SPECT. We also performed first pass radionuclide angiography by TF during maximum exercise on a bicycle ergometer to assess the left ventricular ejection fraction (LVEF). The total examination time was less than 90 minutes. SPECT diagnosis was performed by semi-quantitative analysis. LVEF below 55% was regarded as abnormal. In the patients with angina pectoris, analysis according to the coronary artery showed that the diagnostic accuracy of SPECT was 85.0% for ischemia in the region of the left anterior descending branch (LAD), 87.5% for the left circumflex branch (LCX) and 77.8% for the right coronary artery (RCA). The accuracy of diagnosis for angina pectoris was 82.1%, as determined by SPECT alone, and rose to 89,3% when the LVEF levels were also taken into consideration. In the patients with old myocardial infarction, the diagnostic accuracy of SPECT was 84.2% for the LAD, 92.3% for the LCX and 85.0% for the RCA. Analysis by patients showed that the accuracy of diagnosis for myocardial infarction was 85.7%, as determined by SPECT alone. The diagnostic accuracy, however, rose to 89.3% when the LVEF levels also were taken into consideration. In conclusion, it was demonstrated that this combined diagnostic method was highly reliable for evaluating ischemic heart disease within a short time. (author)

  2. Studies on focal alveolar bone healing with technetium (Tc)-99m labeled methylene diphosphonate and gold-collimated cadmium telluride probe

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchimochi, M.; Hosain, F.; Engelke, W.; Zeichner, S.J.; Ruttimann, U.E.; Webber, R.L. (National Institute of Dental Research, Bethesda, MD (USA))

    1991-01-01

    The benefit of using a collimator for a miniaturized cadmium telluride probe was evaluated by monitoring the bone-healing processes for 13 weeks after the induction of small iatrogenic alveolar bone lesions in one side of the mandible in beagles. Technetium (Tc)-99m labeled methylene diphosphonate (200 to 300 MBq, 5.1 to 8.1 mCi, in a solution of 0.5 to 1 ml, intravenously) was used as a bone-seeking radiopharmaceutical. The radioactivity over the bone lesion (L) and the contralateral normal site (C) in the mandible were measured between 1.5 and 2 hours after injection of the tracer, and the activity ratio L/C served as an index of relative bone uptake. A study of six dogs revealed that the healing response to a hemispheric bone defect of 2 mm diameter in the cortical bone could not be detected by an uncollimated probe, and in a repeated study in two dogs the use of a gold collimator (5 mm in diameter, 5 mm in length) did not increase the L/C ratio significantly. A second study in six dogs with 5 mm lesions showed that although systematic trends in the time courses of the L/C ratio obtained both with and without the collimator could be demonstrated, the L/C ratio of collimated versus uncollimated measurements was significantly (p less than 0.005) increased. In three of the latter six dogs, abscesses developed after 9 weeks, leading to a second increase (p less than 0.05) of the L/C ratio with collimation compared with the noninflammation group; without collimation no significant (p greater than 0.15) difference between the two groups could be demonstrated.

  3. Natural course of portal hemodynamics in patients with chronic liver diseases, evaluated by per-rectal portal scintigraphy with Tc-99m pertechnetate

    Energy Technology Data Exchange (ETDEWEB)

    Shiomi, Susumu; Sasaki, Nobumitsu; Habu, Daiki; Takeda, Tadashi; Nishiguchi, Shuhei; Kuroki, Tetsuo; Tanaka, Takashi; Ochi, Hironobu [Osaka City Univ. (Japan). Medical School

    1998-08-01

    Portal circulation can be evaluated in a relatively noninvasive way by per-rectal portal scintigraphy. We used this method to evaluate portal hemodynamics in patients with chronic liver diseases and underlying hepatic viral infection; the patients did not need surgery or sclerotherapy, or refused it, so changes in the natural course were identified. A solution of Tc-99m pertechnetate was instilled into the rectum, and serial scintigrams were taken while radioactivity curves for the liver and heart were produced. The per-rectal portal shunt index was calculated from the curves. In a longitudinal study, 70 patients (9 with mild chronic hepatitis, 10 with moderate chronic hepatitis, 7 with severe chronic hepatitis, 22 with cirrhosis but without varices, and 22 with both cirrhosis and varices) were examined at least twice at intervals of 12-102 months (mean, 39 months). The shunt index was higher for more severe disorders, increasing in the order of mild chronic hepatitis, moderate chronic hepatitis, severe chronic hepatitis, cirrhosis without varices, and cirrhosis with varices. The mean annual changes in the mean shunt index were 1.0% in mild chronic hepatitis, 4.4% in moderate chronic hepatitis, 6.1% in severe chronic hepatitis, 10.7% in cirrhosis without varices, and 6.2% in cirrhosis and varices. Cirrhotic patients were arbitrarily divided into two groups of roughly equal size on the basis of the shunt index at the first examination. In those with a shunt index of 30% or more, the mean annual change was 4.7%. The patients with a shunt index of less than 30% had a mean annual change of 11.8%. Changes in the portal hemodynamics were not steady. The shunt index rose gradually as disease advanced from mild to moderate and to severe chronic hepatitis and cirrhosis of the liver, after which the index rose rapidly when varices developed, slowing later. (author)

  4. Metastatic calcifications of hyperparathyroidism detected by M.D.P.- Tc 99 m bone scintigraphy in patients with parathyroid carcinoma: A case report; Les calcifications metastatiques de l'hyperparathyroidie identifiees par scintigraphie osseuse au M.D.P.-Tc 99 m dans le cadre du carcinome parathyroidien: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Doudouh, A.; Biyi, A.; Oufroukhi, Y.; Zekri, A. [Hopital Militaire Mohammed-5, Service de Medecine Nucleaire, Rabat (Morocco); Sekkach, Y. [Hopital Militaire Mohammed-5, Service de Medecine B, Rabat (Morocco)

    2008-02-15

    The authors report a case of gastric, renal, pulmonary, and myocardial uptake of M.D.P.-Tc 99 m in a patient with parathyroid carcinoma. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism which becomes complicated during its evolution by metastatic calcifications. Metastatic calcifications are frequently located in lungs and heart. If an adequate treatment is not undertaken, these calcifications progress and evolve into severe respiratory and cardiac complications. In our patient, quasi-complete disappearance of metastatic calcifications on the follow-up bone scintigraphy, performed four weeks after surgical cure of parathyroid tumour, indicates the great interest of this examination in early identification of metastatic calcifications and monitoring of their disappearance after treatment. (authors)

  5. Labelling, biodistribution and compartmental analysis of N-acetylcysteine labelled with Tc-99m. Comparative investigation with with {sup 99m} Tc-MIBI in an in vivo tumoral model; Estudo de marcacao, biodistribuicao e analise compartimental da N-acetil cisteina marcada com Tc-99m. Investigacao comparativa com MIBI-{sup 99m}Tc em modelo tumoral in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Faintuch, Bluma Linkowski

    1997-07-01

    Labelling and biodistribution studies were done with two different ligands, respectively Methoxy isobutyl isonitrile (MIBI) and N-acetylcysteine (NAC), employing Tc-99m as a tracer. The main objective was to assess the pharmacokinetic properties of the second substance, aiming at its possible application in cancer diagnosis. To this purpose an in vivo investigation was done using healthy and tumor-bearing rats with experimental cancer. Images of tumor-bearing rats registered in a scintillation camera indicated that with {sup 99m} Tc-MIBI none of the two selected times was adequate for visualization of the cancer mass. In contrast, {sup 99m} Tc-NAC permitted clear identification of the humor, four hours after injection. The results have demonstrated that {sup 99m} Tc-NAC is a radiopharmaceutical with affinity for cancer tissue and promising for further investigation concerning imaging diagnosis of tumors. (author)

  6. Diagnosis of pulmonary infections with HIV (+) patients. Brought of aerosol DTPA-Tc99m and of Ga67 citrate. Le diagnostic des infections pulmonaires chez les malades VIH (+). Apport de l'aerosol DTPA-Tc99m et du citrate de Ga67

    Energy Technology Data Exchange (ETDEWEB)

    Banzo, I.; Quirce, R.; Serrano, J.; Jimenez, J.; Tabuenca, O.; Carril, J.M. (Hopital Universitaire Valdecilla, Santander (Spain))

    1993-04-01

    The pulmonary clearance of aerosol DTPA-Tc99m is a technology easy to use, well support by patients with immediate results. With the pneumonia at Pneumocystis Carinii (PPC), the clearance is more sensitive and more specific than the thoracic scintigraphy with Ga67. Used with a thorax radiography, results will lead to three directions: High probability of PPC, di phasic curve and very fast T50, equal inferior to 5,10 mn. Low probability of PPC, monoexponential curve and abnormal thorax radiography or di phasic curve with a value T50 superior to 5,10 mn. With these patients other explorations will be made (Ga67, biopsy) and if possible search pulmonary tuberculosis. Extra pulmonary pathology: monoexponential curve associated with a normal thoracic radiography. 2 figs.

  7. The single-plasma-sample method for determining the glomerular filtration rate with Tc-99m-diethylenetriamine pentaacetic acid in childhood and adolescence. Is it age-dependent?

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Kazuo [JR Sapporo General Hospital (Japan); Matsuyama, Takeshi [Tokyo Metropolitan National Health Insurance Organization Fussa Hospital (Japan)

    2002-12-01

    The aim of this study is to assess the accuracy of the pre-existing single-plasma-sample method (SPSM) to measure the glomerular filtration rate (GFR) with Tc-99m-diethylenetriamine pentaacetic acid (Tc-99m-DTPA) in children and adolescents. In addition, the age-independent SPSM is evaluated with two algorithms (Bubeck and Russell) applied for Tc-99m-mercaptoacetyltriglycine (Tc-99m-MAG3) SPSM. The study was performed on 14 patients (12 men and 2 women; age range 3 to 19 yr) with renal diseases. Tc-99m-DTPA (5 MBq/kg) was injected intravenously and thereafter blood samples were taken at 5, 15, 60, 90, 120, 150 and 180 min via the indwelling tube. Radioactivity in the injection syringe and plasma was measured by means of a double-well single-plastic scintillation counter. The true'' GFR as a reference was determined by two methods: 2-exponential curve fitting 7 samples (GFR{sub 7}) and 1-exponential curve fitting 3 samples between 90 and 150 min (GFR{sub 3}) in a slow clearance phase. The GFR{sub 7} and GFR{sub 3} were searched for to the clearance (GFR{sub 1}) estimated from a plasma concentration at various sample times by means of 3 equations designed for children (Groth and Aasted, Ham-I and -II) and 3 for adults (Christensen and Groth, Jacobsson, Itoh). All the SPSM showed close correlations (r>0.95) with the reference methods. Among them, Jacobsson's equation at sample time=120 min tended to be the most accurate (r=0.9826, root mean squared error (RMSE)=7.8 ml/min). On the other hand, Ham-I's equation at sample time=120 min was the most accurate, when it was referred to GFR{sub 3} in correction for overestimation (r=0.9951, RMSE=4.60 ml/min). The Bubeck and Russells' algorithms showed that the regression equation between the GFR{sub 7} and the estimates was different in 2 groups of adults (49 cases) and children/adolescents. Our study indicates that Jacobsson's and Christensen and Groth's equations designed for adults are

  8. Interpretation of Tc-99m sestamibi parathyroid SPECT-CT scans made easy for better surgical outcomes in patients with primary hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Gayed IW

    2016-12-01

    Full Text Available Isis W Gayed,1 Ron J Karni,2 David Q Wan,1 Jeena M Varghese,3 Kelly L Wirfel,3 Kyoung S Won,4 Usha A Joseph1 1Nuclear Medicine Section, Department of Diagnostic and Interventional Imaging, 2Department of Otorhinolaryngology, Head and Neck Surgery, 3Department of Internal Medicine – Endocrinology, Diabetes and Metabolism, Medical School at Houston Health Science Center, Houston, TX, USA; 4Department of Nuclear Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea Objective: This study aims to evaluate the accuracy of Tc-99m sestamibi parathyroid scan (SPS with single-photon emission computerized tomography/computerized tomography (SPECT/CT in patients with primary hyperparathyroidism after optimizing the interpretation of the scans with a systematic and simple method for localization of the abnormal parathyroid gland.Materials and methods: Consecutive patients, who underwent SPS followed by surgical intervention, were included. Data were collected retrospectively including patients’ demographics, serum calcium and parathyroid hormone (PTH levels, SPS findings, and surgical and pathological findings. Our optimized systematic method of interpretation of SPS starts by reviewing initial and 3 hours delayed planar images; subsequently we reviewed coronal and axial SPECT/CT images. A simple clockwise localization of the abnormal gland in relation to the trachea and its level in relation to the thyroid in a cranio-caudal level facilitates intraoperative localization of parathyroid adenomas.Results: A total of 53 patients were included; 9 males and 44 females with an average age of 58.3±14 years. The average preoperative serum calcium and PTH were 10.5 mg/dL and 165.4 pg/m, respectively. The median interval between the scan and operative resection was 50 days. Our SPS interpretation method correlated perfectly with the surgical finding in 48/53 patients (90.6%; it was on the correct side of the surgical finding but not the exact

  9. The change of cerebral blood flow after heart transplantation in congestive heart failure: a voxel-based and automatic VOl analysis of Tc-99m ECD SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Hong, I. K.; Kim, J. J.; Lee, C. H.; Lim, K. C.; Moon, D. H.; Rhu, J. S.; Kim, J. S. [Asan Medical Center, Seoul (Korea, Republic of)

    2007-07-01

    To investigate the change of global and regional cerebral blood flow after heart transplantation (HT) in congestive heart failure (CHF) patients. Twenty-one patients with CHF who underwent HT (45{+-}12 yrs, M/F=19/2) and 10 healthy volunteers (39{+-}13 yrs, M/F = 7/3) were prospectively included. All patients underwent echocardiography and radionuclide angiography including brain and aorta with brain SPECT which was performed after iv bolus injection of Tc-99m ECD (740MBq) before (175{+-}253 days) and after (129{+-}82 days) HT. Patients were divided into two groups according to the interval between HT and postoperative SPECT [early follow-up (f/u): <6 mo, n=14; late f/u: >6 mo, n=7]. Global CBF (gCBF) of bilateral hemispheres were calculated by Patlak graphical analysis. Absolute rCBF map was obtained from brain SPECT by Lassen's correction algorithm. Age-corrected voxel-based analysis using SPM2 and automatic VOl analysis were performed to assess the rCBF change. Cardiac ejection fraction of all patients improved after HT (20.8%{yields}64.0%). gCBF was reduced compared to normal before HT (35.7{+-}3.9 vs. 49.1{+-}3.0 ml/100g/min; p<0.001) and improved postoperatively (46.6{+-}5.4, p<0.001). The preoperative gCBFs of early and late f/u group were not different (34.6{+-}3.2 vs. 38.0{+-}4.4, p=0.149) but postoperative gCBF (43.9{+-}3.7) of late f/u group was higher than those (52.0{+-}4.0) of early f/u group (p<0.001). On voxel-based analysis, preoperative rCBF was reduced in entire brain but most severely in bilateral superior and inferior frontal cortex, supplementary motor area, precuneus and anterior cingulum, compared to normals (uncorrected p<0.001). After HT, rCBF of these areas improved more significantly in late f/u group than in early f/u group but still lower than normals. Global CBF was significantly reduced in CHF patients and improved after HT. rCBFs of the frontal cortex, precuneus and cingulum were most severely reduced and slowly improved after

  10. Effect of Glyceryl Trinatrate and Isosorbide Dinitrate Against Replication of Coxsackievirus B3 in viva%硝酸甘油和硝酸异山梨酯抗柯萨奇B组3型病毒感染的体内实验研究

    Institute of Scientific and Technical Information of China (English)

    孙艳影; 杜凤霞; 夏美玲; 孙艳; 钟照华

    2009-01-01

    目的 研究硝酸甘油(glyeeryl trinatrate,GTN)和硝酸异山梨酯(isosorbide dinitrate,ISDN)抗柯萨奇B组3型病毒(CVB3)的作用,为GTN和ISDN今后在抗CVB性心肌疾病的临床应用提供实验依据.方法 用HeLa细胞扩增并收获CVB3后,测定CVB3的半数组织培养感染剂量(TCID50),BALB/c小鼠腹腔注射5000 TCID50的CVB3,同时给予GTN和ISDN,14天后处死小鼠,取心脏做常规组织病理学检查.结果 用GTN、ISDN保护的小鼠心肌病理标本每视野(x100)病灶数明显低于病毒 对照组,GTN组为0.89±0.18,ISDN组为1.25±0.22.与病毒对照组差异显著(P<0.05).结论 GTN、ISDN等临床常用于抗心绞痛的硝酸酯类药物具有明确的抗CVB3感染BALB/c小鼠心肌细胞的作用.

  11. Evaluation of the biliary gallbladder emptying in patients with calcificant chronic pancreatitis through a scintilographic study with DISIDA Tc-99m; Avaliacao do esvaziamento da vesicula biliar em portadores de pancreatite cronica calcificante, atraves do estudo cintilografico com Tc-99m DISIDA

    Energy Technology Data Exchange (ETDEWEB)

    Pedroso, Martha Regina Arcon

    1996-07-01

    The eventual relation between biliary lithiasis and chronic pancreatitis (CP) has been studied before but the research on the gallbladder involvement in chronic pancreatitis patients are rare, specially from a functional point of view. In order to study that, gallbladder emptying was evaluated in 11 patients with CP and the results were compared and analyzed statistically with the ones observed in 10 controls. This series exclude patients and controls who presented any kind of prior or current affection, or condition, that could interfere with the gastric or gallbladder emptying and the release of the entero pancreatic hormones. Gallbladder emptying was studied through the scintillographic method, using Tc-99m DISIDA, through the calculation of the ejection (EF) of the gallbladder (GB), at 30, 45 and 60 minutes. In the patients this evaluation was studied in two different periods of time with an interval of two to four weeks between them, without (CPWOP) and with (CPWP) the addition of pancreatic extract. The analyses of the results disclosed that the EF of GB at 60 minutes was significantly higher in the controls when compared tro chronic pancreatopaths. On the other hand, the EF of GB in these patients did not show any statistically significant differences after the administration of pancreatic extract. The results suggest that the delay in the gallbladder emptying does not depend exclusively on the eventual alteration in the intestinal phase of the gallbladder stimulation, but it probably also results from the association with other factors involved, as a mechanic factor, which depends on the compression of the main biliary tract through the chronic pathological process located in the cephalic portion of the pancreas. (author)

  12. Activity measurements of the radionuclides 18F and 99mTc for the NMISA, South Africa in the ongoing comparisons BIPM.RI(II)-K4.F-18 and BIPM.RI(II)-K4.Tc-99m

    Science.gov (United States)

    Michotte, C.; Nonis, M.; Van Rooy, M. W.; Van Staden, M. J.; Lubbe, J.

    2017-01-01

    In 2015, comparisons of activity measurements of 18F and 99mTc using the Transfer Instrument of the International Reference System (SIRTI) took place at the National Metrology Institute of South Africa (NMISA, South Africa). Ampoules containing about 25 kBq of 18F and 99mTc solutions were measured in the SIRTI for more than two half-lives. The NMISA standardized the activity in the ampoules by ionization chamber measurements traceable to 4π(LS)β-γ coincidence measurements. The comparisons, identifiers BIPM.RI(II)-K4.F-18 and BIPM.RI(II)-K4.Tc-99m, are linked to the corresponding BIPM.RI(II)-K1.F-18 and BIPM.RI(II)-K1.Tc-99m comparisons and degrees of equivalence with the respective key comparison reference values have been evaluated. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  13. Reproducibility of area at risk assessment in acute myocardial infarction by T1- and T2-mapping sequences in cardiac magnetic resonance imaging in comparison to Tc99m-sestamibi SPECT.

    Science.gov (United States)

    Langhans, Birgit; Nadjiri, Jonathan; Jähnichen, Christin; Kastrati, Adnan; Martinoff, Stefan; Hadamitzky, Martin

    2014-10-01

    Area at risk (AAR) is an important parameter for the assessment of the salvage area after revascularization in acute myocardial infarction (AMI). By combining AAR assessment by T2-weighted imaging and scar quantification by late gadolinium enhancement imaging cardiovascular magnetic resonance (CMR) offers a promising alternative to the "classical" modality of Tc99m-sestamibi single photon emission tomography (SPECT). Current T2 weighted sequences for edema imaging in CMR are limited by low contrast to noise ratios and motion artifacts. During the last years novel CMR imaging techniques for quantification of acute myocardial injury, particularly the T1-mapping and T2-mapping, have attracted rising attention. But no direct comparison between the different sequences in the setting of AMI or a validation against SPECT has been reported so far. We analyzed 14 patients undergoing primary coronary revascularization in AMI in whom both a pre-intervention Tc99m-sestamibi-SPECT and CMR imaging at a median of 3.4 (interquartile range 3.3-3.6) days after the acute event were performed. Size of AAR was measured by three different non-contrast CMR techniques on corresponding short axis slices: T2-weighted, fat-suppressed turbospin echo sequence (TSE), T2-mapping from T2-prepared balanced steady state free precession sequences (T2-MAP) and T1-mapping from modified look locker inversion recovery (MOLLI) sequences. For each CMR sequence, the AAR was quantified by appropriate methods (absolute values for mapping sequences, comparison with remote myocardium for other sequences) and correlated with Tc99m-sestamibi-SPECT. All measurements were performed on a 1.5 Tesla scanner. The size of the AAR assessed by CMR was 28.7 ± 20.9 % of left ventricular myocardial volume (%LV) for TSE, 45.8 ± 16.6 %LV for T2-MAP, and 40.1 ± 14.4 %LV for MOLLI. AAR assessed by SPECT measured 41.6 ± 20.7 %LV. Correlation analysis revealed best correlation with SPECT for T2-MAP at a T2-threshold of 60 ms

  14. Effect of vitamin D/sub 3/, other drugs altering serum calcium or phosphorus concentrations, and desoxycorticosterone on the distribution of Tc-99m pyrophosphate between target and nontarget tissues. [Rats

    Energy Technology Data Exchange (ETDEWEB)

    Carr, E.A. Jr.; Carroll, M.; Montes, M.

    1981-06-01

    Radioactive imaging agents are chemically designed for selective distribution. Another approach to selectivity is to find stable compounds that favorably influence this distribution. Using a rat model of myocardial necrosis, the effects of various stable compounds on the ratio, uptake of Tc-99m pyrophosphate (PPi) by the target lesion/uptake by the principal nontarget, bone (L/B) were studied. Vitamin D/sub 3/s ability to increase L/B was mediated by the hypercalcemia and hyperphosphatemia that it caused. In contrast, pulse doses of desoxycorticosterone acetate (DOCA) at 7 and 6 h before killing increased uptake by lesion, with no change in serum (Ca) and minimal changes in serum (P), (Na), and (K). DOCA also increased the lesion-to-blood ratio. These results encourage further study of DOCA's effect and investigation of other stable drugs that may influence distribution of other imaging agents.

  15. Labelling, biodistribution and compartmental analysis of N-acetylcysteine labelled with Tc-99m. Comparative investigation with with sup 9 sup 9 sup m Tc-MIBI in an in vivo tumoral model

    CERN Document Server

    Faintuch, B L

    1997-01-01

    Labelling and biodistribution studies were done with two different ligands, respectively Methoxy isobutyl isonitrile (MIBI) and N-acetylcysteine (NAC), employing Tc-99m as a tracer. The main objective was to assess the pharmacokinetic properties of the second substance, aiming at its possible application in cancer diagnosis. To this purpose an in vivo investigation was done using healthy and tumor-bearing rats with experimental cancer. Images of tumor-bearing rats registered in a scintillation camera indicated that with sup 9 sup 9 sup m Tc-MIBI none of the two selected times was adequate for visualization of the cancer mass. In contrast, sup 9 sup 9 sup m Tc-NAC permitted clear identification of the humor, four hours after injection. The results have demonstrated that sup 9 sup 9 sup m Tc-NAC is a radiopharmaceutical with affinity for cancer tissue and promising for further investigation concerning imaging diagnosis of tumors.

  16. Discordant Findings of Skeletal Metastasis Between Tc99m MDP Bone Scans and F18 FDG PET/CT Imaging for Advanced Breast and Lung Cancers—Two Case Reports and Literature Review

    Directory of Open Access Journals (Sweden)

    Yu-Wen Chen

    2007-12-01

    Full Text Available Traditionally, Tc99m methyl diphosphate (MDP bone scintigraphy provides high-sensitivity detection of skeletal metastasis from breast and lung cancers in regular follow-up. Fluorodeoxyglucose (FDG positron emission tomography/computed tomography (PET/CT, based on the glucose metabolism of malignant cells, plays a role in describing rumor growth, proliferation of neoplasm and the extent of metastasis. In general, concordant findings of skeletal metastasis are seen on both types of image, especially in cases of breast and lung cancer. However, there were extremely discordant findings of skeletal metastasis between bone scans and F18 FDG PET/CT imaging in two cases among 300 consecutive F18 FDG PET/CT follow-up exams of patients with malignancies, during the past year, in our center. Both cases, one of breast cancer and one of lung cancer, had negative bone scintigraphic findings, but a diffusely high grade of F18 FDG avid marrow infiltration in the axial spine, leading to the diagnosis of stage IV disease in both cases. Owing to variant genetic aberrance of malignance, F18 FDG PET/CT reveals direct evidence of diffuse, rapid neoplasm metabolism in the bone marrow of the spine, but not of secondary osteoblastic reactions in vivo. F18 FDG PET/CT should always be employed in the follow-up of patients with malignancies.

  17. KEY COMPARISON Update of the BIPM.RI(II)-K1.Tc-99m comparison of activity measurements for the radionuclide 99mTc to include new results for the LNE-LNHB and the NPL

    Science.gov (United States)

    Michotte, C.; Courte, S.; Ratel, G.; Moune, M.; Johansson, L.; Keightley, J.

    2010-01-01

    In 2007 and 2008 respectively, the Laboratoire national de métrologie et d'essais-Laboratoire national Henri Becquerel (LNE-LNHB), France and the National Physical Laboratory (NPL), UK, submitted ampoules with between 10 MBq and 130 MBq activity of 99mTc to the International Reference System (SIR), to update their results in the BIPM.RI(II)-K1.Tc-99m comparison. Together with the four other national metrology institutes (NMI) that are participants, thirteen samples have been submitted since 1983. The key comparison reference value (KCRV) has been recalculated to include the latest primary results of the PTB and the LNE-LNHB as this makes the evaluation more robust. The degrees of equivalence between each equivalent activity measured in the SIR are given in the form of a matrix for all six NMIs. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI Section II, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  18. 核素显像诊断持续性不卧床腹膜透析所致腹腔渗漏%Diagnosis of Peritoneal Leaks in Peritoneal Dialysis Using Tc-99m Pertechnetate Scintigraphy

    Institute of Scientific and Technical Information of China (English)

    张卫方; 韩庆峰; 张燕燕; 黄俊

    2012-01-01

    Purpose To illustrate usefulness of Technetium-99m pertechnetate peritoneal scintigraphy in patients undergoing CAPD with suspected leakage of dialysate fluid from the peritoneal cavity. Materials and Methods Fourteen patients with complaints of genital and/or inguinal edema or pleural effusion during CAPD were referred for peritoneal scintigraphy to look for peritoneal leaks. After mixing Tc-99m Pertechnetate in peritoneal dialysis solution and administering into the peritoneal cavity, dynamic and delayed images were acquired to monitor the distribution of the fluid. Results Patients were divided into two groups. Group 1 included 8 patients with pleural effusion. Abnormal uptake was shown in the chest within 1-2 hours in six patients, confirming the presence of peritoneal diaphragmatic leakage. Two cases were diagnosed with the delayed images and lateral views. In 2 of the eight patients, renal transplantation and diaphragm repair surgery were performed. Pleural effusion decreased or disappeared in another six patients after modifying the dialysis solution or switch to hemodialysis. Group 2 included 6 patients with groin and/or perineal edema. Five patients showed intense activity accumulation extending to the groin or genital area consisting with dialysate leakage. No obvious abnormal accumulation of radiotracer was observed in the genital area in 6-hour images in one patient. After hydrocele repair surgery in two cases and four patients changed to intermittent or hemodialysis treatment, groin and genital edema were significantly reduced or disappeared. Conclusion Nuclear peritoneal scintigraphy using Tc-99m Pertechnetate can be employed successfully to demonstrate the peritoneal leaks, and help clinicians decide therapeutic approaches.%目的 探讨高锝酸盐与透析液混合滴注腹腔核素显像对持续性不卧床腹膜透析(CAPD)患者可疑腹腔渗漏的诊断价值.资料与方法 14例肾功能衰竭患者行持续性不卧床腹膜透析后出

  19. Quantitative Evaluation of the Antiischemic Effect of Isosorbide Dinitrate

    Institute of Scientific and Technical Information of China (English)

    Meng Fanbo; Xu Wengui; Sun Pinghui; Yang Ping; Wang Wenzhi

    2005-01-01

    Objectives To evaluate the anti-ischemic effect of ISDN on the patients with coronary heart disease. The change in the size of the defect area as percentage of the entire myocardium as determined by the unfolded surface mapping between the baseline and after ISDN infusion reflects the anti-ischemic effect of ISDN. Methods and Results 99m Tc-MIBI myocardial perfusion SPECT images were acquired,and reconstruction of the bull's eye map and unfolded surface mapping were performed according to the dates of tomography images. In the group Ⅰ (99mTc-MIBI was injected at 30 minutes after the start of ISDN iv drip):at the 65% threshold value, the percentage of the defect area size in the whole ventricle was 33.01 ±5.35% at baseline, (28.9 ±5.23)% after ISDN was infused (P < 0.05); at the 55% threshold value, the percentage of the defect area size in the whole ventricle was (22.06±5.58)% at baseline, (19.60±4.07)% after ISDN was infused (P < 0.05); the sum of defect blood ST segments is 60 at baseline, 51 after ISDN was infused. In the group Ⅱ (99mTc-MIBI was injected at 60 minutes after the start of ISDN iv drip): at the 65% threshold value, the percentage of the defect area size in the whole ventricle was (29.20±5.08)% at baseline,(20.81±4.16)% after ISDN was infused (P < 0.001 );at the 55% threshold value, the percentage of the defect area size in the whole ventricle was (21.2 ±5.49)% at baseline, (17.52 ±5.59)% after ISDN was infused (P < 0.001); the sum of defect blood ST segments is 58 at baseline, 47 after ISDN was infused.In the group Ⅲ (99mTc-MIBI was injected at 150 minutes after the start of ISDN iv drip): at the 65% threshold value, the percentage of the defect area size in the whole ventricle was (32.87 ±6.46)% at baseline,(20.81±4.16)% after ISDN was infused (P < 0.001);at the 55% threshold value, the percentage of the defect area size in the whole ventricle was (18.42 ±5.17)% at baseline, (14.18±3.61)% after ISDN was infused (P< 0.001); the sum of defect blood ST segments was 64 at baseline, 41 after ISDN was infused.Conclusions The unfolded surface mapping of 99mTc-MIBI myocardial perfusion image can be used as a method of quantitatively evaluating the anti-ischemic effect of drugs and ISDN iv drip can improve the blood flow in myocardium (myocardium perfusion).

  20. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT–CT, ultrasound and first results of {sup 18}F-fluorocholine PET–CT

    Energy Technology Data Exchange (ETDEWEB)

    Kluijfhout, Wouter P., E-mail: WPKluijfhout@gmail.com [Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht (Netherlands); Vorselaars, Wessel M.C.M., E-mail: W.M.Vorselaars@umcutrecht.nl [Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht (Netherlands); Vriens, Menno R., E-mail: mvriens@umcutrecht.nl [Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht (Netherlands); Borel Rinkes, Inne H.M., E-mail: I.H.M.BorelRinkes@umcutrecht.nl [Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht (Netherlands); Valk, Gerlof D., E-mail: G.D.Valk@umcutrecht.nl [Department of Endocrinology, University Medical Center Utrecht, Utrecht (Netherlands); Keizer, Bart de, E-mail: B.deKeizer@umcutrecht.nl [Department of Nuclear Medicine and Radiology, University Medical Center Utrecht, Utrecht (Netherlands)

    2015-09-15

    Highlights: • We examined an optimal pre-operative imaging strategy. • Goal was to perform minimal invasive parathyroidectomy. • Ultrasound significantly decreased the PPV when added to SPECT–CT. • {sup 18}F-fluorocholine was positive in 4/5 cases with negative conventional imaging. - Abstract: Objective: Assessment of the diagnostic value of ultrasound (US), single photon-emission computed tomography–computed tomography (SPECT–CT) and {sup 18}F-fluorocholine (FCH) PET–CT for preoperative localization of hyper-functioning parathyroid(s) in order to create a more efficient diagnostic pathway and enable minimal invasive parathyroidectomy (MIP) in patients with biochemical proven non-familial primary hyperparathyroidism (pHPT). Methods: A single-institution retrospective study of 63 consecutive patients with a biochemical diagnosis of non-familial pHPT who received a Tc-99m-sestamibi SPECT–CT and neck ultrasound. Surgical findings were used in calculating the sensitivity and the positive predictive value (PPV) of both imaging modalities. Furthermore we present 5 cases who received additional FCH PET–CT. Results: A total of 42 (66.7%) patients underwent MIP. The PPV and sensitivity of SPECT–CT, 93.0% and 80.3%, were significantly higher than those of US with 78.3% and 63.2%, respectively. Adding US to SPECT–CT for initial pre-operative localization did not significantly increase sensitivity but did significantly decrease PPV. Performance of US was significantly better when performed after SPECT–CT. {sup 18}F-fluorocholine PET–CT localized the hyper-functioning parathyroid gland in 4/5 cases with discordant conventional imaging, enabling MIP. Conclusion: SPECT–CT is the imaging modality of choice for initial pre-operative localization of hyper-functioning parathyroid gland(s) in patients with biochemical pHPT. Ultrasound should be performed after SPECT–CT for confirmation of positive SPECT–CT findings and for pre-operative marking

  1. Localizacao de glandulas paratireoides ectopicas e supranumerarias em pacientes com hiperparatireoidismo secundario e terciario: descricao cirurgica e correlacao com ultrassonografia e cintilografia Tc99m-Sestamibi pre-operatorios

    Directory of Open Access Journals (Sweden)

    Jose Santos Cruz de Andrade

    2014-01-01

    Full Text Available Introdução: O hiperparatireoidismo é uma consequência metabólica esperada na doença renal crônica (DRC. Paratireoides (PT ectópicas e/ou supranumerárias podem ser causa de falha cirúrgica nos pacientes submetidos à paratireoidectomia total (PTX. Objetivo: Definir cirurgicamente a localização das PT, em pacientes com hiperparatireoidismo associado à DRC, e correlacionar esses achados com os exames pré-operatórios. Materiais e métodos: Foi conduzido um estudo retrospectivo com 166 pacientes submetidos à PTX. A localização das PT no intraoperatório foi registrada, sendo classificada como tópica ou ectópica. A localização pré-operatória, definida pela ultrassonografia (USG e pela cintilografia Tc99m-Sestamibi (MIBI, foi comparada com aos achados cirúrgicos. Resultados: Nos 166 pacientes, foram identificadas 664 PT. Foram classificadas como tópicas e ectópicas 577 (86,4% e 91(13,6% glândulas, respectivamente. Oito PT supranumerárias foram encontradas (7 tópicas e 1 ectópica. As localizações mais comuns de PT ectópicas foram as regiões retroesofágica e tímica. Associadas, a USG e a MIBI não identificaram 56 glândulas (61,5% ectópicas. Entretanto, a MIBI foi positiva para 69,7% daquelas localizadas nas regiões tímicas e mediastinal. Conclusão: A presença de glândulas ectópicas e supranumerárias em pacientes com hiperparatireoidismo associado à DRC é significativa. Os exames de imagem pré-operatórios não localizaram a maioria das glândulas ectópicas. A MIBI pode ter importância na identificação de PT nas regiões tímica e mediastinal.

  2. [An approach for comparative quantification of myocardial blood flow (O-15-H2O-PET), perfusion (Tc-99m-tetrofosmin-SPECT) and metabolism (F-18-FDG-PET)].

    Science.gov (United States)

    Schäfer, W M; Nowak, B; Kaiser, H J; Block, S; Koch, K C; vom Dahl, J; Büll, U

    2001-10-01

    In the present study a new approach has been developed for comparative quantification of absolute myocardial blood flow (MBF), myocardial perfusion, and myocardial metabolism in short-axis slices. 42 patients with severe CAD, referred for myocardial viability diagnostics, were studied consecutively with 0-15-H2O PET (H2O-PET) (twice), Tc-99m-Tetrofosmin SPECT (TT-SPECT) and F-18-FDG PET (FDG-PET). All data sets were reconstructed using attenuation correction and reoriented into short axis slices. Each heart was divided into three representative slices (base, midventricular, apex) and 18 ROIs were defined on the FDG PET images and transferred to the corresponding H2O-PET and TT-SPECT slices. TT-SPECT and FDG-PET data were normalized to the ROI showing maximum perfusion. MBF was calculated for all left-ventricular ROIs using a single-compartment-model fitting the dynamic H2O-PET studies. Microsphere equivalent MBF (MBF_micr) was calculated by multiplying MBF and tissue-fraction, a parameter which was obtained by fitting the dynamic H2O-PET studies. To reduce influence of viability only well perfused areas (> 70% TT-SPECT) were used for comparative quantification. First and second mean global MBF values were 0.85 ml x min-1 x g-1 and 0.84 ml x min-1 x g-1, respectively, with a repeatability coefficient of 0.30 ml x min-1 x g-1. After sectorization mean MBF_micr was between 0.58 ml x min-1 x ml-1 and 0.68 ml x min-1 x ml-1 in well perfused areas. Corresponding TT-SPECT values ranged from 83% to 91%, and FDG-PET values from 91% to 103%. All procedures yielded higher values for the lateral than the septal regions. Comparative quantification of MBF, MBF_micr, TT-SPECT perfusion and FDG-PET metabolism can be done with the introduced method in short axis slices. The obtained values agree well with experimentally validated values of MBF and MBF_micr.

  3. Depiction of Nidi and Fibrovascular Zones of Osteoid Ostemas Using Gamma Correction Tc 99m HDP Pinhole Bone Scan and Conventional Radiograph, and Correlation with CT, MRI, and PVC Phantom Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Youg Whee [Sung Ae Hospital, Seoul (Korea, Republic of); Kim, Sung Hoon; Chung, Yong An; Bahk, Won Jong; Park, Jung Mee; Kang, You Mee; Choi, Woo Hee; Park, Young Ha; Sohn, Hyung Sun; Kim, Byung Ki; Chung, Soo Kyo [The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2011-03-15

    For the precise imaging diagnosis of osteoid osteoma (OO), the identification of the nidus and fibrovascular zone (FVZ) is essential. However, the latter sign has received little attention because it is difficult to demonstrate. We applied the recently introduced gamma correction (GC) to depict the FVZ on pinhole bone scan (PBS), conventional radiography (CR), and computed tomography (CT). Non gamma correction MRI was also analyzed for reference. Ten patients with histologically proven diagnoses of OO were enrolled in this retrospective study. PBS, CR, and CT were processed by GC to demonstrate the nidi and FVZ as distinct yet integrating components of OO. PBS was performed using a 4mm pinhole collimator 3 h after iv injection of 925 to 1, 110 MBq (25 to 30mCi) of Tc 99m HDP, and anteroposterior and mediolateral CR and transverse CT were taken according to the standard technique. MRI sequences included T1 and T2 weighted images. For gamma correction, we utilized the Photo Correction Wizard program of ACD Photo Editor v3. 1. A team of three qualified nuclear physician radiologists, two nuclear physicians, and one MRI specialist read bone scans, radiographs, and MRIs of OO according to each specialty, and orthopaedic aspects and histology were reviewed by one qualified orthopedic surgeon and two qualified pathologists, respectively. Each observer first read the images separately with basic information about the aim of the study given and then in concert. Interpretive disagreement was settled by discussion and consensus. On pinhole scan, nidi were presented as areas of intense tracer uptake in all cases, and, importantly after GC, a thin ring like zone with lower tracer uptake became visible in seven out of ten cases. GCCR also revealed a thin lucent zone that circumscribed the nidi in six out of ten cases and GCCT in two of four cases. MRI, without GC, presented nidi with high signal in the center and a thin ring like zone with low signal in the periphery in five out

  4. Current status of Tc-99m production in Thailand

    Energy Technology Data Exchange (ETDEWEB)

    Charoen, Sakda [Office of Atomic Energy for Peace, Bangkok (Thailand)

    2003-03-01

    Technetium-99m is the workhorse of nuclear medicine and currently accounts for over 80% of all in vivo diagnostic procedures. In Thailand, Office of Atomic Energy for Peace (OAEP) had experiences in production of Technetium-99m by solvent extraction process and alternative technology for Technetium-99m generator based on zirconium molybdate and titanium molybdate gel generators were also studied. The paper describes past experiences and future plan of Technetium-99m production in Thailand. (author)

  5. Evaluation of myocardial revascularization utilizing Tc-99m pyrophosphate.

    Science.gov (United States)

    Liddicoat, J E; Bekassy, S M; Johnson, P C; Ajmani, S K; DeBakey, M E

    1974-01-01

    Early clinical application of technetium 99m labeled pyrophosphate for cardiac imaging has revealed a safe noninvasive method of determining areas of impaired myocardial perfusion in patients with atherosclerotic occlusive coronary artery disease. Using this method, we were able to demonstrate improvement in myocardial blood supply following coronary artery bypass surgery.

  6. Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE

    Directory of Open Access Journals (Sweden)

    NADEZDA VUKICEVIC

    2001-09-01

    Full Text Available The reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9 % NaCl. The conditions of the storage of the inactive kit solutions till labeling were examined. The main problem is the stablity of the reductant stannous ions which is very difficult to predict. To stabilize and ensure a good quality of the labeled radiopharmaceuticals, ascorbic or gentisic acid were added. It was found that the best results were obtained by keeping the samples frozen at –20 ?C. Both stabilizers can be used but for an effective protection much lower concentrations of ascorbic acid are needed. Its concentrations of 12–60 mg/ml of the kit, stabilized dimercaptosuccinate (DMS and pyrophosphate (PyP for about 7–8 days. The solution of 2,3-dicarboxypropane-1,1-diphosphonate (DPD was found to be stable even without the stabilizer. This could be attributed probably to the chemical nature of this complex. However, in routine praxis the applied procedure demands great care and personel very experienced in radiopharmacy.

  7. Bepaling van isosorbide-dinitraat en zijn metabolieten isosorbide-2-mononitraat en isosorbide-5-mononitraat in ratteserum met behulp van capillaire gaschromatografie en elektron-capture detectie

    NARCIS (Netherlands)

    Tepas BCA; Groot G de; Wildt DJ de

    1989-01-01

    In dit rapport wordt een gevoelige methode beschreven voor de kwantitatieve bepaling in ratteserum van het vaatverwijdende middel isosorbide-dinitraat (ISDN) en zijn metabolieten isosorbide-2- mononitraat (2-ISMN) en isosorbide-5-mononitraat (5-ISMN). Deze stoffen worden uit serum geextraheerd m

  8. Isosorbide

    Science.gov (United States)

    ... in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.tell your doctor if you may be dehydrated, ...

  9. Thermoplastic Polyurethanes with Isosorbide Chain Extender

    Energy Technology Data Exchange (ETDEWEB)

    Javni, Ivan; Bilic, Olivera; Bilic, Nikola; Petrovic, Zoran; Eastwood, Eric; Zhang, Fan; Ilavsky, Jan

    2015-12-15

    Isosorbide, a renewable diol derived from starch, was used alone or in combination with butane diol (BD) as the chain extender in two series of thermoplastic polyurethanes (TPU) with 50 and 70% polytetramethylene ether glycol (PTMEG) soft segment concentration (SSC), respectively. In the synthesized TPUs, the hard segment composition was systematically varied in both series following BD/isosorbide molar ratios of 100 : 0; 75 : 25; 50 : 50; 25 : 75, and 0 : 100 to examine in detail the effect of chain extenders on properties of segmented polyurethane elastomers with different morphologies. We found that polyurethanes with 50% SSC were hard elastomers with Shore D hardness of around 50, which is consistent with assumed co-continuous morphology. Polymers with 70% SSC displayed lower Shore A hardness of 74–79 (Shore D around 25) as a result of globular hard domains dispersed in the soft matrix. Insertion of isosorbide increased rigidity, melting point and glass transition temperature of hard segments and tensile strength of elastomers with 50% SSC. These effects were weaker or non-existent in 70% SSC series due to the short hard segments and low content of isosorbide. We also found that the thermal stability was lowered by increasing isosorbide content in both series.

  10. Technetium-99m tetrofosmin imaging in thyroid diseases: comparison with Tc-99m-pertechnetate, thallium-201 and Tc-99m-methoxyisobutylisonitrile scans

    Energy Technology Data Exchange (ETDEWEB)

    Klain, M. [Centro di Studio per la Medicina Nucleare, Consiglio Nazionale delle Ricerche (CNR) Napoli (Italy)]|[Univ. di Napoli (Italy). Medicina Nucleare; Maurea, S. [Medicina Nucleare, Istituto Nazionale dei Tumori, Napoli (Italy); Cuocolo, A. [Centro di Studio per la Medicina Nucleare, Consiglio Nazionale delle Ricerche (CNR) Napoli (Italy)]|[Univ. di Napoli (Italy). Medicina Nucleare; Colao, A. [Endocrinologia, Centro di Studio per la Medicina Nucleare del Consiglio Nazionale delle Ricerche (CNR), Napoli (Italy)]|[Univ. di Napoli (Italy); Marzano, L. [Endocrinologia, Centro di Studio per la Medicina Nucleare del Consiglio Nazionale delle Ricerche (CNR), Napoli (Italy)]|[Univ. di Napoli (Italy); Lombardi, G. [Endocrinologia, Centro di Studio per la Medicina Nucleare del Consiglio Nazionale delle Ricerche (CNR), Napoli (Italy)]|[Univ. di Napoli (Italy); Salvatore, M. [Centro di Studio per la Medicina Nucleare, Consiglio Nazionale delle Ricerche (CNR) Napoli (Italy)]|[Univ. di Napoli (Italy). Medicina Nucleare

    1996-12-01

    In this study, tetrofosmin whole-body scintigraphy was performed in 35 patients with evidence of thyroid diseases. All patients underwent laboratory evaluation of thyroid function as well as {sup 99m}Tc pertechnetate scan, thallium-201 {sup 99m}Tc-methoxyisobutylisonitrile (MIBI) whole-body studies. Thyroid images were semi-quantitatively analysed by a 4-point score: 0=no significant uptake; 1=uptake increased but inferior to normal thyroid tissue; 2=uptake equal to normal thyroid tissue; 3=uptake superior to normal thyroid tissue. A total of 41 thyroid nodules were detected, of which 15 were goitre nodules, 13 adenomas and 13 malignant lesions. In goitre nodules, concordant results of tetrofosmin and pertechnetate uptake (score 1 or 0) were observed in the majority of lesions (87%). In function adenomas both tetrofosmin uptake and pertechnetate uptake were score 3. In non-function adenomas tetrofosmin uptake was score 3, while pertechnetate uptake was score 0. In six malignant lesions, tetrofosmin uptake was score 3, while pertechnetate uptake was score 0; in the other seven lesions, where a prevalence of goitre abnormalities was observed, results of tetrofosmin and pertechnetate uptake were similar (score 0 or 1). In (70%) patients with malignant nodules, whole-body tetrofosmin images showed increased abnormal uptake in a total of 28 extra-thyroid tumour sites, as subsequently confirmed by other techniques. When tetrofosmin images were compared to {sup 201}Tl and {sup 99m}Tc-MIBI scans, concordant results were observed in all cases. In conclusion, tetrofosmin imaging may be particularly useful to characterize and stage patients with malignant thyroid nodules; it shows similar results to thallium but provides better image quality. Comparable findings were observed between tetrofosmin and MIBI studies. Thus, tetrofosmin may be an alternative to thallium and MIBI in the aforementioned patients. (orig.). With 4 figs., 3 tabs.

  11. [Quantification of separate renal function using Tc 99m DTPA and Tc 99m DMSA. Correlations between individual isotopic data and creatinine clearance].

    Science.gov (United States)

    Chevet, D; Moisan, A; Le Pogamp, P; Le Cloirec, J; Wehbe, B; Herry, J Y

    1984-01-01

    The purpose of this prospective study (30 controls and 100 renal patients) is to compare one to each other the values of renal function measured with: 1--the DTPA 99mTc , 2--the DMSA 99mTc , and 3--the creatinine clearance. After the control values being established, correlations are done for the whole group (n = 130) between the creatinine clearance, the DTPA 99mTc clearance and the fixation rate of the DMSA 99mTc . The correlations obtained are:--Clcr Versus Cldtpa = 0,91.--Clcr Versus % Dmsa = 0,90. - Cldtpa Versus % Dmsa = 0,93. and indicate the two isotopic tests performed give similar quantitative results than creatinine clearance. Camera and computer allow to measure the separate renal function one by one, the two isotopic test giving similar values for each kidney. The results of these studies give a good concordance with the observed diseases, except for partial renal artery stenosis. The pyelic retention of DMSA 99mTc product, in condition of ureteral compression, gives a potential overestimation of this test and is a matter to debate. The extreme simplicity and facility of DMSA 99mTc procedures make this investigation accessible to any patient and give excellent morphological and functional tests. DTPA 99mTc clearances--global and separate kidney--give a more sensitive approach than DMSA 99mTc does because vascular captation , elimination rates could be focused. DTPA 99mTc procedure is to be used in patients with transplanted kidney, silent IVP kidney, contrast media contraindication or for exploring glomerular clearance without urine collection.

  12. Comparative uptake of Tc-99m sestamibi and Tc-99m tetrofosmin in cancer cells and tissue expressing P-Glycoprotein or multidrug resistance associated protein

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jung Ah; Lee, Jae Tae; Yoo, Jung Ah [School of Medicine, Kyungpook National University, Daegu (Korea, Republic of)] (and others)

    2005-02-15

    {sup 99m}Tc-sestamibi(MIBI) and {sup 99m}Tc-tetrofosmin have been used as substrates for P-glycoprotein (Pgp) and multidrug resistance associated protein (MRP), which are closely associated with multidrug resistance of the tumors. To understand different handling of radiotracers in cancer cell lines expressing Pgp and MRP, we compared cellular uptakes of {sup 99m}Tc-MIBI and {sup 99m}Tc-tetrofosmin. The effects of cyclosporin A (CsA), well-known multidrug resistant reversing agent, on the uptake of both tracers were also compared. HCT15/CL02 human colorectal cancer cells for Pgp expressing cells, and human non-small cell lung cancer A549 cells for MRP expressing cells, were used for in vitro and in vivo studies. RT-PCR, western blot analysis and immunohistochemistry were used for detection of Pgp and MRP. MDR-reversal effect with CsA was evaluated at different drug concentrations after incubation with MIBI or tetrofosmin. Radioactivities of supernatant and pellet were measured with gamma well counter. Tumoral uptake of the tracers were measured from tumor bearing nude mice treated with or without CsA. RT-PCR, western blot analysis of the cells and immunochemical staining revealed selective expression of Pgp and MRP for HCT15/CL02 and A549 cells, respectively. There were no significant difference in cellular uptakes of both tracers in HCT15/CL02 cells, but MIBI uptake was slightly higher than that of tetrofosmin in A549 cells. Co-incubation with CsA resulted in a increase in cellular uptakes of MIBI and tetrofosmin. Uptake of MIBI or tetrofosmin in HCT15/CL02 cells was increased by 10-and 2.4-fold, and by 7.5 and 6.3-fold in A549 cells, respectively. Percentage increase of MIBI was higher than that of tetrofosmin with CsA for both cells ({rho} < 0.05). In vivo biodistribution study showed that MIBI (114% at 10 min, 257% at 60 min, 396% at 24C min) and tetrofosmin uptake (110% at 10 min, 205% at 60 min, 410% at 240 min) were progressively increased by the time, up to 240 min with CsA. But increases in tumoral uptake were not significantly different between MIBI and tetrofosmin for both tumors. MIBI seems to be a better tracer than tetrofosmin for evaluating MDR reversal effect of the modulators in vitro, but these differences were not evident in vivo tumoral uptake. Both MIBI and tetrofosmin seem to be suitable tracers for imaging Pgp-and MRP=mediated drug resistance in tumors.

  13. Genotoxic effect of radio marked lymphocytes using Tc-99m complexes; Efecto genotoxico del radiomarcado de linfocitos empleando complejos de Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Pedraza L, M.; Ferro F, G.; Mendiola C, M.T.; Morales R, P. [Instituto nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    The genotoxic effect of radio marked lymphocytes was evaluated using {sup 99m}-Tc-HMPAO and {sup 99m}-Tc- gentisic acid complexes. With the results of this work it is pretended to contribute to the knowledge of genetic and structural damages that provokes the radiation in the marked lymphocytes. The d, 1-HMPAO was synthesized in laboratory with a yielding of 30 %. The radiochemical purity of the complexes was greater than 85%. Mouse lymphocytes obtained of sanguineous volumes 2 ml were used. The radio marked efficiency of cells was 19.6 {+-} 6.4% and 25.6 {+-} 5.8% for {sup 99m}Tc-HMPAO and {sup 99m} Tc gentisic acid respectively. The genotoxic effect was evaluated using the technique of Unicellular Electrophoresis in Micro gel (Comet assay). The results showed that both {sup 99m} Tc complexes produce genotoxicity due to their capacity to penetrate cells, therefore the Auger and M internal conversion electrons place all their energy obtaining doses of Gray order. (Author)

  14. Thermal Decomposition Kinetics of Triethylene Glycol Dinitrate

    Institute of Scientific and Technical Information of China (English)

    CHEN,Pei(陈沛); ZHAO,Feng-Qi(赵凤起); LUO,Yang(罗阳); HU,Rong-Zu(胡荣祖); LI,Shang-Wen(李上文); GAO,Yin(高茵)

    2004-01-01

    The thermal behavior and kinetic parameters of the decomposition reaction of triethylene glycol dinitrate (TEGDN) in a temperature-programmed mode at different pressures (0.1, 2, 4 and 6 MPa) have been investigated by means of DSC and TG-DTG. The results show that the properties of the thermal decomposition of TEGDN are affected by the change of pressure, and the kinetic model function, the apparent activation energy Ea and TEGDN obtained by the values Teo and Tpo of the onset temperature Te and the peak temperature TP when the heating rate tends to zero are 191.05,209.86 ℃ at 0.1 MPa, 207.59 and 221.65 ℃ at 2 MPa, respectively.

  15. Soybean oil-isosorbide-based waterborne polyurethane-urea dispersions.

    Science.gov (United States)

    Xia, Ying; Larock, Richard C

    2011-03-21

    A series of soybean oil-based amide diol-isosorbide waterborne polyurethane-urea (PUU) dispersions have been successfully prepared, with amounts of isosorbide ranging from 0 to 20 wt % of the total diol content. The thermal and mechanical properties of the resulting PUU films have been characterized by dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, and mechanical testing. The results reveal that the glass transition temperature is increased with increased amounts of isosorbide, and the mechanical properties are improved significantly with the incorporation of isosorbide. For example, the Young's modulus increases from 2.3 to 63 MPa and the ultimate tensile strength increases from 0.7 to 8.2 MPa when the isosorbide amount is increased from 0 to 20 wt %. The thermal stability decreases slightly with the incorporation of isosorbide. This work provides a new way of utilizing biorenewable materials, such as isosorbide and a soybean oil-based amide diol, for the preparation of high-performance polyurethane-urea coatings.

  16. Intravaginal isosorbide dinitrate or misoprostol for cervical ripening prior to induction of labour: a randomised controlled trial.

    Science.gov (United States)

    Haghighi, L; Homam, H; Raoofi, Z; Najmi, Z

    2013-04-01

    In this randomised double-blind controlled trial, 130 healthy pregnant women with term pregnancy who scheduled for labour induction with Bishop's score misoprostol (25 μg), which were repeated after 4 h as needed. The efficacies of medications were evaluated by predetermined primary and secondary outcome variables for cervical ripening and induction of labour and delivery. There was no significant difference in Bishop's score 8 h after drug administration between the ISDN and misoprostol groups. However, in the ISDN group, labour induction was needed more frequently and the time from start of medication to the beginning of active phase of labour was significantly longer.

  17. Scintigraphic study in peripheral osteomyelitis (diabetic foot) with MDP-Tc99m, gallium 67 and antigranulocytes antibodies Tc99m. Etude scintigraphique de l'osteomyelite peripherique (pied diabetique) avec MDP-Tc99m, gallium 67 et anticorps antigranulocytes Tc99m

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez Gadea, L.; Martin Curto, L.M.; Bas, C.; Rioja, M.E.; Vila, T.; Mitjavila, M.; Crespo, A. (Hopital Ramon y Cajal, Madrid (Spain))

    1993-04-01

    With isotopic technologies, scintigraphy using technetied phosphonates is the basic exploration relating to osseous pathology. With antibodies antigranulocytes, it is a reliable method which can be used in the diagnosis of osteomyelitis of diabetic feet. It gives an anatomic and diagnostic information. 12 refs., 1 tab.

  18. Chronic recurrent multifocal osteomyelitis demonstrated by Tc-99m methylene diphosphonate bone scan

    DEFF Research Database (Denmark)

    Lise, Hobolt; Nemery, Michel; Albrectsen, Jens;

    2008-01-01

    A 12-year-old Middle Eastern girl presented with abdominal pain, weight loss, and intermittent pain in both thighs. She was initially suspected of Crohn disease, but this diagnosis was excluded after extensive gastromedical evaluation. Plain x-rays of the femora were normal, whereas the initial T...... osteomyelitis (CRMO). The patient's symptoms disappeared spontaneously, but reappeared 1.5 years later, which led to a new MDP bone scan that showed normal findings. Udgivelsesdato: 2008-Jan...

  19. Evaluation of Tc-99m leukocyte scan in the diagnosis of acute appendicitis

    Energy Technology Data Exchange (ETDEWEB)

    Butler, J.A.; Marcus, C.S.; Henneman, P.L.; Inkelis, S.H.; Wilson, S.E.

    1987-05-01

    A new /sup 99m/Tc Microlite leukocyte scan was performed in 38 patients to assess its value in the diagnosis of acute appendicitis. Autologous leukocytes are labeled with /sup 99m/Tc by inducing phagocytosis of /sup 99m/Tc albumin microcolloid particles. The advantages of this test over the standard indium-111 scan include superior imaging capability, a marked reduction (greater than 75%) in the radiation dose, and performance of the test including labeling, in less than 3 hr. Imaging is performed at 5-90 min postinjection of labeled cells. There were 19 male and 19 female patients with ages ranging from 10 to 80 years, in whom the diagnosis of appendicitis was indeterminate on clinical examination. Of the 13 of the 38 patients (34%) who came to surgery 12 had acute appendicitis. The WBC scan correctly identified 10 of the 12 cases of appendicitis. There were two false-negative studies. In the nonoperative group of 25 patients admitted for observation, 21 studies were reported as negative and four identified other sites of inflammation. All patients with a negative study have remained asymptomatic on follow-up. With a sensitivity of 83% (10/12) and a specificity of 100% (26/26) the /sup 99m/Tc leukocyte scan provides a rapid and highly accurate method for diagnosis of appendicitis in this preliminary study of patients with equivocal clinical exams.

  20. Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

    Directory of Open Access Journals (Sweden)

    Funda Aydın

    2012-04-01

    Full Text Available Objective: 99mTc labeled hexamethylpropylene amine oxime (HMPAO white blood cell (WBC scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of this retrospective study was to evaluate the value of 99mTc-HMPAO labeled WBC scintigraphy in pediatric patients. Material and Methods: The study was conducted between January 2006 and December 2008 and included 13 patients (5 boys, 8 girls; mean age 6.9±6.2 years. Those patients who had suspicion of bone infection (n=7, fever of unknown origin (n=3, and suspicion of acute appendicitis (n=3 were evaluated retrospectively. 99mTc-HMPAO labeled WBC scintigraphy imaging was performed to all patients. Diagnosis was done according to operation and pathological results or clinical follow-up. Results: 99mTc-HMPAO labeled WBC scintigraphy has been found to be true positive in 6 cases, true negative in 6 cases, and false negative in one patient who had fewer unknown origin. The false negative case has been found to have encephalitis with MRI. Conclusion: Leukocyte scintigraphy has been described as a useful diagnostic tool in the diagnosis of suspicion of bone infection, fever of unknown origin and suspicion of acute appendicitis. 99mTc-HMPAO labeled WBC scintigraphy is a rapid and very accurate method for detecting those pathologies. Our results showed that WBC scintigraphy might be reliably used for diagnosis of suspected bone infection and acute appendicitis, fever of unknown origin, and acute appendicitis, in pediatric patient population. (MIRT 2012;21:13-18

  1. Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

    OpenAIRE

    Funda Aydın3; Arzu Kın Cengiz; Fırat Güngör

    2012-01-01

    Objective: 99mTc labeled hexamethylpropylene amine oxime (HMPAO) white blood cell (WBC) scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of this retrospective study was to evaluate the value of 99mTc-HMPAO labeled WBC scintigraphy in pediatric...

  2. Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients.

    Science.gov (United States)

    Aydın, Funda; Kın Cengiz, Arzu; Güngör, Fırat

    2012-04-01

    (99m)Tc labeled hexamethylpropylene amine oxime (HMPAO) white blood cell (WBC) scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of this retrospective study was to evaluate the value of (99m)Tc-HMPAO labeled WBC scintigraphy in pediatric patients. The study was conducted between January 2006 and December 2008 and included 13 patients (5 boys, 8 girls; mean age 6.9±6.2 years). Those patients who had suspicion of bone infection (n=7), fever of unknown origin (n=3), and suspicion of acute appendicitis (n=3) were evaluated retrospectively. (99m)Tc-HMPAO labeled WBC scintigraphy imaging was performed to all patients. Diagnosis was done according to operation and pathological results or clinical follow-up. (99m)Tc-HMPAO labeled WBC scintigraphy has been found to be true positive in 6 cases, true negative in 6 cases, and false negative in one patient who had fewer unknown origin. The false negative case has been found to have encephalitis with MRI. Leukocyte scintigraphy has been described as a useful diagnostic tool in the diagnosis of suspicion of bone infection, fever of unknown origin and suspicion of acute appendicitis. (99m)Tc-HMPAO labeled WBC scintigraphy is a rapid and very accurate method for detecting those pathologies. Our results showed that WBC scintigraphy might be reliably used for diagnosis of suspected bone infection and acute appendicitis, fever of unknown origin, and acute appendicitis, in pediatric patient population. None declared.

  3. Tc-99m labeled triethelene tetraamine polysterene resin gastric emptying studies in bulimia patients

    Energy Technology Data Exchange (ETDEWEB)

    Shih Weijen; Castellanos, F.X.; Domstad, P.A.; DeLand, F.H.; Humphries, L.; Digenis, G.A.

    1987-07-01

    To evaluate gastric emptying in patients with bulimia, 20 patients (all women, ranging in age from 12 to 49 years) with upper gastrointestinal symptoms ingested 150-200 ..mu..Ci/sup 99m/ Tc-triethelene tetraamine polysterene resin in cereal and had scintigraphy in the supine position. Data were accumulated at 5 min intervals to determine the gastric emptying time (GET). The results showed that the gastric emptying time was prolonged in 12 patients and decreased in 8. All 12 patients with prolonged emptying time were given 10 mg metoclopramide intravenously; 9 of these had a good response and 3 had no response. Although all patients had subjective symptoms of gastric dysfunction, the results indicate that about 60% had delayed and 40% had rapid gastric emptying. The findings of two extremes of gastric emptying time remain to be explained, however, this enables (Albibi and McCullum 1983) objective documentation of gastric emptying as this technique (American Psychiatric Association 1980) can separate those patients with rapid GET from those with prolonged GET, who might benefit from metoclopramide.

  4. Radiographically Occult Latent Radiogenic Osteosarcoma Uncovered on Tc-99m Methylene-diphosphonate Bone Scintigraphy

    Directory of Open Access Journals (Sweden)

    Prashant Jolepalem

    2013-01-01

    Full Text Available We present a case of a 70-year-old male who was referred for a technetium-99m methylene-diphosphonate bone scan for mild left hip pain and an elevated alkaline phosphatase level of 770 units/L. No additional information was provided and the patient′s history was limited due to a language barrier. We were able to ascertain that the patient had a remote history of prostate cancer, which had been treated with radiation. Originally, we felt the bone scan was compatible with Paget′s disease; however, further work-up revealed the presence of osteosarcoma, which was potentially radiation-induced.

  5. Tc-99m Labeled and VIP-Receptor Targeted Liposomes for Effective Imaging of Breast Cancer

    Science.gov (United States)

    2006-09-01

    phospholipid mixed micelles to human breast cancer cells using quantum dots. CRS 2006. 15) Koo, O., Rubinstein, I., Onyuksel, H. Camptothecin in...Real time tracking of actively targeted phospholipid mixed micelles to human breast cancer cells using quantum dots. CRS 2006. 15) Koo, O... Shankar G, Townsend M, Fadeeva J, Betts V, et al. The role of cell derived oligomers of Ab in Alzheimers disease and avenues for therapeutic

  6. Tc-99m-labeled Rituximab for Imaging B Lymphocyte Infiltration in Inflammatory Autoimmune Disease Patients

    NARCIS (Netherlands)

    Malviya, G.; Anzola, K. L.; Podesta, E.; Lagana, B.; Del Mastro, C.; Dierckx, R. A.; Scopinaro, F.; Signore, A.

    2012-01-01

    The rationale of the present study was to radiolabel rituximab with 99m-technetium and to image B lymphocytes infiltration in the affected tissues of patients with chronic inflammatory autoimmune diseases, in particular, the candidates to be treated with unlabelled rituximab, in order to provide a r

  7. Disparate appearance of intrascrotal masses during Tc-99m-pertechnetate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bocobo, G.C.; Turner, J.W.; Spencer, R.P.

    1986-10-01

    Two cases are presented of males with pain and swelling in the left testicular area. In the first, the left side had less perfusion than the right. Static images revealed a large photopenic area in the left testicular sac, with a medial area of hyperactivity. At surgery, there was a left epididymitis (corresponding to the small area of hyperactivity on the image) and a large collection of fluid probably secondary to the inflammation. The distention likely produced a tamponade effect with reduced perfusion. In the second case, there was slightly greater perfusion to the left. There was a semilunar area of activity equal to that of the background, with a surrounding band of intensely increased uptake. The right side showed the same findings on a smaller scale. There was an abscess involving each testis. Intrascrotal masses may distort the expected findings on testicular-scrotal imaging.

  8. A new method for brain functional study using Tc-99m HMPAO SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Momose, Toshimitsu; Kosaka, Noboru; Nishikawa, Junichi; Ohtake, Tohru; Watanabe, Toshiaki; Iio, Masahiro (Tokyo Univ. (Japan). Faculty of Medicine)

    1989-04-01

    The distribution of {sup 99m}Tc-HMPAO in brain is in proportion to regional cerebral blood flow (rCBF) and can be interpreted as functional mapping. To evaluate local changes in CBF during neuropsychological testing, we developed a new subtraction method using HMPAO and SPECT. With patients resting, 15 mCi of HMPAO was injected and the first acquisition was performed, lasting a total of 10 minutes. Soon after the end of the first scan, patients were requested to undergo Buschke's memory test or to repeat words or numbers (repetition test). During the task, an additional 15 mCi of HMPAO was injected using the same position as in the first scan, and a second acquisition was started. A functional image was made by subtracting the image in the first scan from that in the second. In two patients with transient global amnesia and two normal controls, Buschke's memory test was performed in combination with SPECT. A relative increase in activity was seen in the thalamus, subthalamic area, hippocampus, and some cortial areas, apparently reflecting local functional change induced by the memory task. In two patients with moderate Alzheimer's disease with severe memory loss, no increase was detected in these areas. In one patient with aphasia, the repetition test with SPECT was correlated with the WADA test and dichotic listening test, and good agreement was obtained. In conclusion, our new SPECT technique is useful in detecting alterations in rCBF during mental activity and can be applied to neurophysiological studies. (author).

  9. Lung or liver: An imaging dilemma on Tc-99m macroaggregated albumin lung perfusion scintigraphy

    OpenAIRE

    Jain, Tarun Kumar; Phulsunga, Rohit Kumar; Kumar, Sunil; Sood, Ashwani; Bhattacharya, Anish; Mittal, Bhagwant Rai

    2015-01-01

    We present a 10-year-old boy having the bronchiectasis who was subjected to lung perfusion scintigraphy before lung resection surgery to assess the lung parenchymal function. It revealed unusual tracer distribution in right upper body that was mimicking to be liver. It was unusual unless there were some shunts bypassing the lung uptake or faulty radiopharmaceutical preparation. However by bringing down the image window, it became clear that radiopharmaceutical distribution was in thorax only ...

  10. Usefulness of per-rectal portal scintigraphy with Tc-99m pertechnetate for galactosemia in infants

    Energy Technology Data Exchange (ETDEWEB)

    Shiomi, Susumu; Sasaki, Nobumitsu; Ikeoka, Naoko; Kuroki, Tetsuo; Okano, Yoshiyuki; Kawabe, Joji; Ochi, Hironobu [Osaka City Univ. (Japan). Medical School

    1998-12-01

    Galactosemia discovered by newborn screening is rarely caused by enzyme deficiency. It has recently been reported that among patients without enzyme deficiency portosystemic shunting may be a cause of galactosemia in some patients. We did per-rectal portal scintigraphy in patients with such galactosemia detected during screening of newborns to examine the usefulness of this method for the diagnosis of portosystemic shunts via the inferior mesenteric vein. The subjects were eight neonates with galactosemia without enzyme deficiency detected during screening. A solution containing technetium-99m pertechnetate was instilled into the rectum, and serial scintigrams were taken while radioactivity curves for the liver and heart were recorded sequentially. The per-rectal portal shunt index was determined by calculating the ratio for counts of the liver to counts for the heart integrated for 24 seconds immediately after the appearance of the liver time-activity curve. A portosystemic shunt was detected in both of the patients with a shunt index of 30% or more, but not in the six patients with a shunt index less than 30%. The blood galactose levels of these six patients later entered the reference range. This method is noninvasive and there is little exposure to the radionuclide. It seemed to be useful for the diagnosis of portosystemic shunt in newborns with galactosemia without enzyme deficiency. (author)

  11. Myocardial uptake of Tc-99m MDP in chronic renal failure with cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Eun; Sohn, Hyung Sun; Chung, Yong An; Park, Young Ha; Kim, Sung Hoon; Chung, Soo Kyo [The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2000-06-01

    A uremic patient on hemodialysis, who had concurrent cardiomyopathy showed intense myocardial uptake of {sup 99m}Tc-methylene diphosphonate (MDP). The presumed cause of uptake in the myocardium is metastatic calcification due to hypercalcemia secondary to the renal failure. However, supplementary mechanism caused by cardiomyopathy should be considered. We describe a case with bone tracer uptake in the myocardium in the absence of infarction in a patient with chronic renal failure.

  12. Additional extrarenal abnormalities seen in Tc-99m DTPA renal flow study

    Energy Technology Data Exchange (ETDEWEB)

    Shih, Wei-Jen; Riley, C.; Domstad, P.A.; Pulmano, C.

    1988-04-01

    During /sup 99m/Tc-DTPA renal flow studies, extrarenal abnormalities have been found to include aortic abnormalities (aneurysm, ectasia, thrombosis, and abruptly decreased flow), splenic abnormalities (enlarged, small, or absent spleen), hepatic arterialization, and very slow circulation. In addition to the above abnormal findings, we add three more extrarenal pathologies that may be concomitantly found with renal flow study : pleural effusion(s), malignancy of the abdomen, and anemia and/or skeletal metastases.

  13. Diffuse pulmonary ossification detected by bone scanning with Tc-99m hydroxymethylene diphosphate

    Energy Technology Data Exchange (ETDEWEB)

    Saks, D.A.; McClees, E.C.; Fajman, W.A.; Hollinger, W.M.; Gilman, M.J.

    1984-10-01

    Diffuse pulmonary ossification (DPO) is a rare pathologic finding of heterotropic bone formation within the lungs. It has been associated with mitral stenosis, chronic left ventricular failure, interstitial fibrosis, metastatic breast cancer, pulmonary amyloidosis, histoplasmosis, and chronic busulfan therapy. This patient represents a case associated with Placidyl use.

  14. New bone-seeking agent. Animal study of Tc-99m-incadronate

    Energy Technology Data Exchange (ETDEWEB)

    Shigematsu, Makoto; Shiomi, Susumu; Iwao, Hiroshi; Ochi, Hironobu [Osaka City Univ. (Japan). Graduate School of Medicine

    2002-02-01

    Disodium cycloheptylaminomethylenediphosphonate monohydrate (incadronate disodium) is a third-generation bisphosphonate compound which potently inhibits bone resorption, and a highly effective drug in the treatment of metastatic bone disease. We first labeled incadronate disodium with {sup 99m}Tc, and examined its biodistribution and bone uptake after intravenous injection in rats to assess its potential for clinical use as a bone-seeking agent for judgment of the therapeutic effect of incadronate on bone metastases. Bone scan with {sup 99m}Tc-labeled incadronate ({sup 99m}Tc-incadronate) may yield important information prior to the use of incadronate for treatment of bone metastases. Synthesis of {sup 99m}Tc-incadronate was carried out by reduction of {sup 99m}Tc-pertechnetate in the presence of SnCl{sub 2} and N{sub 2} gas. Normal rats were injected with 18.5 MBq (0.5 mCi) {sup 99m}Tc-incadronate in a volume of 0.1 ml intravenously and then sacrificed at 15 min, 30 min, 1 h or 2 h (six rats at each time point) after injection. Samples of muscle, stomach, small intestine, kidney, liver and bone (femur) were taken and weighed. In addition, a 1-ml sample of blood was drawn from the heart, and urine was taken from the urinary bladder immediately after sacrifice. Samples were measured for radioactivity and expressed as percent uptake of injected dose per gram or per milliliter (% ID/g or ml). Bone-to-blood and bone-to-muscle uptake ratios were determined from the % ID/g or ml values for these organs. The greatest accumulation of {sup 99m}Tc-incadronate was found in bone. Radioactivity in bone was as high as 3.22{+-}0.68% ID/g at 2 hours after injection. Scintigraphic images of {sup 99m}Tc-incadronate in normal rats revealed highly selective skeletal uptake. {sup 99m}Tc-incadronate exhibited high uptake in bone, and relatively low uptake in soft tissue, suggesting that it may be useful as a bone-seeking agent for judgment of the therapeutic effect of incadronate on bone metastases, by determining the degree of its accumulation in metastatic bone lesions. (author)

  15. [Indirect articular lymphography using Tc 99m-labeled Dextran in animals].

    Science.gov (United States)

    Albuquerque, M; Pedroso de Lima, J; Cardoso, A; Mendes, F; Pires, J; Canha, N; Branco, R

    1990-01-01

    Looking for a standardization of the articular lymphoscintigraphy, an experimental research was conducted on 14 dogs injected in the ankle, with 2.5 mCi of 99m Tc-labeled dextran (P.M. = 70,000). Good scintigraphic images of the lymphatic system have been obtained. After having collected blood samples during the experimentation as well as aliquots of organs and of tissues, after the necropsy of the animal, it was verified that the 99m Tc-labeled dextran was useful for quantitative studies of the articular lymphatic drainage. The activities attained, in the drainage lymph nodes of injected articulation, are 152 times superior to those obtained in the kidney and one gramma of popliteal ganglion was 8929 times more active than one gramma of blood. The dextran 70,000, widely used in our clinical routine, can be injected to the human being, without any risk, and it may be the tracer which permits studies of the articular lymphatic drainage and the usage of the lymphoscintigraphy, already in expansion in many other Medicine branches, in the articular studies, nowadays.

  16. New method for the selective labeling of erythrocytes in whole blood with Tc-99m

    Science.gov (United States)

    Srivastava, S.C.; Babich, J.W.; Straub, R.; Richards, P.

    1984-01-27

    Method and kit are described for the preparation of /sup 99m/Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for the reduction of technetium.

  17. Cintilografia do miocárdio com tecnécio 99m-MIBI e administração de adenosina em portadores de doença arterial coronária: correlação dos resultados com a angiografia coronária e o ultra-som intracoronário Adenosine myocardial perfusion SPECT with Tc-99m-MIBI in patients with obstructive coronary artery disease: correlation between quantitative coronary angiography and intravascular ultrasound measurements

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Mastrocolla

    2006-01-01

    Full Text Available OBJETIVO: Estabelecer a correlação da cintilografia de perfusão do miocárdio (CPM com Tecnécio 99m-MIBI (MIBI e injeção de adenosina, empregando a angiografia coronária quantitativa (ACQ e o ultra-som intracoronário (UIC como comparação. MÉTODOS: Estudo de 70 pacientes com doença arterial coronária (DAC, encaminhados à CPM com MIBI e adenosina. As manifestações clínicas, do eletrocardiograma (ECG e os resultados das imagens foram correlacionadas às variáveis da análise visual e quantitativa da angiografia, bem como ao UIC. RESULTADOS: A média de idades foi de 60,6 anos, com 39 pacientes do sexo masculino. A angiografia coronária evidenciou estenose do diâmetro da luz (E% de 49,94% em 105 artérias, com reavaliação à ACQ em 83 artérias (79% e média de 44,20%, pOBJECTIVE: To correlate myocardial perfusion scintigraphy (MPS with Tc-99m-MIBI and adenosine infusion using quantitative coronary angiography (QCA and intravascular ultrasound (IVUS. METHODS: Seventy patients with coronary artery disease (CAD referred for myocardial perfusion scintigraphy (MPS with MIBI and adenosine were studied. Clinical, electrocardiographic (ECG, and scintigraphic findings were correlated with variables of visual and quantitative angiographic analysis, as well as to those of IVUS. RESULTS: The mean age of patients was 60.6 years, and 39 were male. Coronary angiography showed percentage of diameter stenosis (% DS of 49.94% in 105 arteries, 83 of which were re-evaluated by QCA (79%, mean of 44.20%, p<0.05. ST-segment depression during adenosine infusion was associated with higher degrees of % DS (55.0% vs. 47.8%, p<0.05. Scintigraphic ischemia was correlated with greater cross-sectional area of lumen obstruction by IVUS (% CSA. Clinical, ECG, and IVUS findings were considered together and expressed as global ischemic versus non-ischemic responses. Ischemia was associated with lower values of minimal lumen diameter (MLD and minimal lumen area

  18. Sorbitol dehydration into isosorbide in a molten salt hydrate medium

    NARCIS (Netherlands)

    Li, J.; Spina, A.; Moulijn, J.A.; Makkee, M.

    2013-01-01

    The sorbitol conversion in a molten salt hydrate medium (ZnCl2; 70 wt% in water) was studied. Dehydration is the main reaction, initially 1,4- and 3,6-anhydrosorbitol are the main products that are subsequently converted into isosorbide; two other anhydrohexitols, (1,5- and 2,5-), formed are in less

  19. Continuous Isosorbide Production From Sorbitol Using Solid Acid Catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Williamson, R.; Holladay,J.; Jaffe, M.; Brunelle, D.

    2006-09-29

    This is a final report for a project funded by the US Department of Agriculture and managed by the US Department of Energy. The Iowa Corn Promotion Board was the principal contracting entity for the grant. The Iowa Corn Promotion Board subcontracted with General Electric, Pacific Northwest National Lab and New Jersey Institute of Technology to conduct research in this project. The Iowa Corn Promotion Board and General Electric provided cost share for the project. The purpose of this diverse collaboration was to integrate both the conversion and the polymer applications into one project and increase the likelihood of success. This project has led to additional collaborations among other polymer companies. The goals of the project were to develop a renewable route to isosorbide for commercialization that is economically competitive with all existing production technologies and to develop new applications for isosorbide in various products such as polymers and materials. Under this program a novel process for the production of isosorbide was developed and evaluated. The novel process converts corn based sorbitol into isosorbide using a solid catalyst with integrated water removal and product recovery. In addition the work under this program has identified several novel products based on isosorbide chemistries. These market applications include: epoxy resins, UV stabilizers, plasticizers and polyesters. These market applications have commercial interest within the current polymer industry. This report contains an overview summary of the accomplishments. Six inventions and four patent applications have been written as a result of this project. Additional data will be published in the patent applications. The data developed at New Jersey Institute of Technology was presented at two technical conferences held in June of 2006. Several companies have made inquiries about using this material in their products.

  20. Bio-Based Polyurethane Containing Isosorbide for Use in Composites and Coatings

    Science.gov (United States)

    2015-04-01

    ARL-TR-7259 ● APR 2015 US Army Research Laboratory Bio-Based Polyurethane Containing Isosorbide for Use in Composites and...copyright notation hereon. ARL-TR-7259 ● APR 2015 US Army Research Laboratory Bio-Based Polyurethane Containing Isosorbide for Use...4. TITLE AND SUBTITLE Bio-Based Polyurethane Containing Isosorbide for Use in Composites and Coatings 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  1. Rapid conversion of sorbitol to isosorbide in hydrophobic ionic liquids under microwave irradiation.

    Science.gov (United States)

    Kamimura, Akio; Murata, Kengo; Tanaka, Yoshiki; Okagawa, Tomoki; Matsumoto, Hiroshi; Kaiso, Kouji; Yoshimoto, Makoto

    2014-12-01

    Sorbitol was effectively converted to isosorbide by treatment with [TMPA][NTf2 ] in the presence of catalytic amounts of TsOH under microwave heating at 180 °C. The reaction completed within 10 min and isosorbide was isolated to about 60%. Ionic liquids were readily recovered by an extraction treatment and reused several times.

  2. FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF ISOSORBIDE MONONITRATE

    Directory of Open Access Journals (Sweden)

    Bhanushali Akash K

    2011-03-01

    Full Text Available The aim of the present study was to formulate and evaluate the mouth dissolving tablets of isosorbide mononitrate. Drug delivery systems are becoming more complex as pharmaceutical scientist acquires better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the last decade, the demand of fast disintegrating tablet has been growing mainly for geriatric and pediatric patients, because of swallowing difficulties, the characteristics of fast disintegrating tablet for potential emergency treatment. The superdisintegrant used in this study was crospovidone. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time and dissolution study. The tablets were prepared by direct compression method.

  3. [The influence of isosorbide mononitrate on skin blood flow in patients with Raynaud's syndrome].

    Science.gov (United States)

    Gross, Robert; Galus, Krzysztof; Zajac, Stanisław; Jedrasik, Maciej

    2002-01-01

    The influence of isosorbide mononitrate on skin blood flow in the pulp of finger by means of laser-Doppler flowmetry was evaluated in 19 women with Raynaud's syndrome. Skin blood flow changes were measured after cooling the hand. Isosorbide mononitrate decreased the influence of cooling on skin blood flow in the pulp of finger. This finding supports the theory that endothelial dysfunction is one of the reasons of Raynaud's syndrome. We suppose that application of isosorbide mononitrate should be useful in prevention and the treatment of Raynaud's phenomenon attacks.

  4. Tc-99m MDP bone clearance - a new technique designed to evaluate bone metabolism on a quantitative basis. Tc-99m-MDP Knochenclearance, ein neues Verfahren zur quantitativen Beurteilung des Knochenstoffwechsels

    Energy Technology Data Exchange (ETDEWEB)

    Fegert, J.

    1984-09-18

    A new technique for the quantitative evaluation of bone metabolism (bone clearance) is described, the diagnostic value of which at the hospital level is rated higher than that of qualitative bone scanning, as it permits metabolic imbalances in the bone to be ascertained at an earlier stage and to reduce the radiation exposure of the patients and hospital staff. Bone clearance was expressed as the ratio between the per minute accumulation of activity in the bone and the plasma activity per ml and calculated on the basis of the measured elimination rate of 99m-Tc MDP from the blood and soft tissues. The latter, in turn, was determined by subtraction of the glomerular filtration rate from the wholebody retention of 113mIn DTPA. The results obtained were corrected for the relative amounts of radioactivity bound to plasma proteins. Considerably increased clearance values were determined for patients showing metabolic or systemic disorders and, in particular, thyrotoxicosis (normal thyroid findings in the scintigrams) as well as in cases of premature ossification of epiphyseal cartilages in a growing organism. Markedly decreased clearance values were seen in patients receiving cortisone. The measured values were easily reproducible and consistent with the relevant hormone levels, while being completely independent of the renal function. (TRV).

  5. Interpretation of distant focal accumulations revealed by bone scintigraphy using Tc-99m HMDP in patients with oral malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Tsuyoshi; Morita, Yasuhiko; Iwashita, Youichirou; Kawabata, Yoshihiro; Noikura, Takenori [Kagoshima Univ. (Japan). Dental School

    2000-06-01

    Focal accumulations in the skeleton were analyzed in order evaluate the usefulness of bone scintigraphy in the detection of distant skeletal metastases originating from malignant oral tumors. Of 350 patients who underwent bone scintigraphy, 62 patients who showed distant focal accumulations in the skeleton were selected. Observations were performed on 12 skeletal regions: the skull, facial bone, clavicle, rib, scapula, sternum, cervical spine, thoracic spine, lumbar spine, pelvis, upper, and lower extremities. Distant focal accumulations were classified into 3 degrees: very hot, moderately hot and warm. A diagnosis of metastatic focal accumulation was made with reference to the CT, MR, X-ray and Ga-67 images, clinical features, and laboratory data. Four of the 350 cases showed skeletal metastases (1.1%). Sixty-two of the 350 patients showed 106 distant focal accumulations, with 10 accumulations proving to be skeletal metastases. The common sites of the skeletal metastases were the lumbar spine, rib, cervical spine, and sternum. Patients with skeletal metastases had a tendency to show distant focal accumulations of very hot images in some skeletal sites, and these focal accumulations were usually accompanied by severe pain. The most common cause of distant focal accumulations except metastasis was traumatic injury. The results in the present study indicate that the distant focal accumulations accompanied by severe pain and simultaneously observed in more than one skeletal site can be interpreted as skeletal metastases. (author)

  6. Tc-99m-HMPAO-Labeled leukocyte SPECT/CT in pediatrics: detecting Candida albicans tricuspid endocarditis

    Energy Technology Data Exchange (ETDEWEB)

    Calais, Jeremie; Edet-Sanson, Agathe; Gaucher, Stephane; Vera, Pierre; Cloirec, Joseph Le [Henri Becquerel Cancer Center and Rouen Univ. Hospital, Rouen (France)

    2015-12-15

    These results led to performing TEE, which showed tricuspid vegetation. Blood cultures were then positive to Candida albicans. Control blood cultures and TEE performed 6 weeks later after adapted antifungal therapy remained negative. In accordance with the results of Erba and al., this case illustrates the usefulness of late thoracic SPECT-CT acquisition of a WBC scan in a patient with high clinical suspicion of endocarditis and identified risk factors but inconclusive echocardiographic findings.

  7. Experimental infections of the musculoskeletal system: evaluation with MR imaging and Tc-99m MDP and Ga-67 scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Beltran, J.; McGhee, R.B.; Shaffer, P.B.; Olsen, J.O.; Bennett, W.F.; Foster, T.R.; McCalla, M.S.; Iskra, L.A.; Blagg, R.L.; Biller, D.S.

    1988-04-01

    Acute osteomyelitis, soft-tissue infection, or both were experimentally produced in 38 New Zealand white rabbits, and three-phase technetium-99m methylene diphosphonate, gallium-67, and magnetic resonance (MR) images were obtained 7 or 14 days after infection. There was no significant difference between radionuclide studies and MR images in the detection of osteomyelitis, but MR imaging was significantly more sensitive (100% vs. 69%; P less than .01) in the detection of soft-tissue infection. In addition, cellulitis could not be distinguished from soft-tissue abscess on radionuclide studies, whereas MR imaging was 92% accurate in depicting soft-tissue abscesses. Further research is necessary to determine how to relate these findings to true human clinical situations.

  8. A rare case of polyostotic fibrous dysplasia assessed by bone scintigraphy with Tc-99m methylene diphosphonate (MDP)

    Energy Technology Data Exchange (ETDEWEB)

    Di Leo, C.; Ardemagni, A.; Bestetti, A.; Tagliabue, L.; Del Sole, A.; Conte, A.; Tarolo, G.L. [Milano Univ. (Italy). Servizio di Medicina Nucleare

    1999-07-01

    A 66-year-old man affected by polyostotic form of fibrous dysplasia in consequence of worsening of lower extremity bone pain aggravated by walking and concomitant increase of serum alkaline phosphatase and osteocalcin, was subjected first to a radionuclide study. Bone scan demonstrated a pathological uptake of the radiotracer in the craniofacial bones, right scapula, left and right posterior ribs, right hemipelvis and lower extremities confirming the diagnosis but establishing especially the extent of bone involvement, greater than expected on the basis of symptoms and X-ray findings, underlying the importance of nuclear medicine imaging in the assessment and follow-up of this rare disease. (orig.) [German] Bei einem 66jaehrigen Mann, der an der polyostotischen Form der fibroesen Dysplasie leidet, wurde aufgrund einer Verschlimmerung der Knochenschmerzen im Bereich der unteren Extremitaeten, die sich beim Gehen verschlechterten, und einer gleichzeitigen Erhoehung der Serumwerte fuer alkalische Phosphatase und Osteocalzin erstmals eine Radionuklid-Untersuchung durchgefuehrt. Das Knochenszintigramm zeigte eine pathologische Aufnahme des Radiotracers in den kraniofazialen Knochen, im rechten Schulterblatt, den linken und rechten posterioren Rippen, im Bereich von rechtem Hemipelvis und unteren Extremitaeten; damit wird die Diagnose bestaetigt, vor allem jedoch das Ausmass der Knochenbeteiligung nachgewiesen, das ueber das ausgehend von den Symptomen und Roentgenbefunden erwartete Ausmass hinausgeht; die Bedeutung des nuklearmedizinischen bildgebenden Verfahrens zur Beurteilung und Verlaufskontrolle dieser seltenen Erkrankung wird dadurch unterstrichen. (orig.)

  9. Tc-99m-Labeled-rhTSH Analogue (TR1401) for Imaging Poorly Differentiated Metastatic Thyroid Cancer

    NARCIS (Netherlands)

    Galli, Filippo; Manni, Isabella; Piaggio, Giulia; Balogh, Lajos; Weintraub, Bruce D.; Szkudlinski, Mariusz W.; Fremont, Valerie; Dierckx, Rudi A. J. O.; Signore, Alberto

    2014-01-01

    Background: Differentiated thyroid carcinomas originating from thyroid follicular cells are frequent tumors of the thyroid with relatively good prognosis due to improved surgical techniques and follow-up procedures. Poorly differentiated thyroid cancers, which lose iodine uptake ability, in most cas

  10. Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema

    DEFF Research Database (Denmark)

    Toyserkani, Navid M; Hvidsten, Svend; Tabatabaeifar, Siavosh

    2017-01-01

    34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m-labeled human serum albumin and sequential 5 min imaging for 5 hours. The mean transit time (MTT) in the arms was calculated...... based on time activity curves generated from injection site and arm regions. Visual lymphedema scoring was performed based on dermal backflow and lymph node presence. Excess arm volume was calculated from circumference measurements. RESULTS: The MTT (mean ± SD) was significantly longer in the lymphedema......, 18.6-68.7 minutes; P lymphedema from...

  11. survey of myocardial perfusion scan findings using Tc99 m in patients referred to Birjand nuclear medicine in 2012

    Directory of Open Access Journals (Sweden)

    Mahmud Reza Tavakolli

    2013-02-01

    Materials and Methods: The present descriptive-analytical study was done on 350 patients who had been referred to Birjand nuclear medicine center during the second half of 2011. The necessary data was collected by the means of a questionnaire addressing demographic information, personal and family history of diseases, cardiac abnormalities, blood pressure, diabetes, and the type of heart lesions. The obtained data,then, was fed into SPSS software (V:19 and statistical analysis was performed. Results: Mean age of the cases was 57.1±11.8 years. Women consisted 58.6% of them,86.6% were citizens,and . 34% had a familial history of. Heart lesions were diagnosed in 40% out of which 85% had ischemic problems and 15% suffered myocardial infarction.Relative frequency of in men was higher compared to women (P<0.001.It was found that there was a significant relationship between and diabetes (P<0.05.But, no significant relationship was found between and their types with age, habitation, and familial ties. Conclusion: The present study showed that myocardial perfusion imaging, as a non-aggressive method in diagnosing heart lesions, can be helpful.

  12. The grade of vesicoureteral reflux in voiding cystourethrography: comparison with ultrasonography and Tc99m-DMSA renal scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    To evaluate the prevalence of abnormalities seen on sonography and renal scintigraphy, according to the grade of vesicoureteral reflux (VUR) on in voiding cystourethrography(VCUG). One hundred and forty-nine patients (age range: 1 months-10 years) with urinary tract infection underwent sonography, VCUG, and renal scans, and 32 showed VUR on VCUG. We retrospectively evaluated the frequency and characteristic findings of sonographic abnormalities according to the grade of VUR, and also the frequency of cortical defects seen on renal scans of 32 patients with VUR. The remaining 117 patients without VUR were also evaluated for the frequency of abnormal findings seen on sonography and renal scans. Among 32 patients (49 kidneys) with VUR, abnormal findings were not detected in 17 (29 kidneys) on sonography; thus, findings were abnormal in 15 (20 kidneys, 41%). Among these 20 kidneys, renal calyceal and/or pelvic dilatation and dilatation of distal ureter were seen in 11, all of which were grade 4-5 VUR. Renal pelvic dilatation only was noted in eight kidneys; two were grade 1-3 and six were grade 4-5 VUR. Nineteen patients (24 kidneys, 49%) showed focal cortical defects on renal scintigraphy. Six kidneys were grade 1-3, and 18 kidneys were grade 4-5 VUR. Of 117 patients without VUR, 34 patients (29%) showed renal pelvic dilatation on sonography and in 14 patients (12%), cortical defects were seen on renal scintigraphy. Among 32 patients with VUR, 41% showed abnormal sonographic findings and in 49%, cortical defects were seen on renal scintigraphy. With a higher grade of VUR, the prevalence of abnormalities increased on both sonography and renal scintigraphy. Sonographic demonstration of renal caliceal and/or pelvic dilatation associated with ipsilateral distal ureteric dilatation was the characteristic finding in high grade VUR.=20.

  13. The role of Tc-99m DTPA aerosol scintigraphy in the differential diagnosis of COPD and asthma.

    Science.gov (United States)

    Karacavus, Seyhan; Intepe, Yavuz S

    2015-04-01

    Chronic obstructive lung disease (COPD) and asthma are characterized as similar to each other in causing airway obstruction and being an inflammatory process. The purpose of this study was to investigate whether technetium-99m diethylenetriaminepentaacetic acid ((99m) Tc-DTPA) aerosol scintigraphy could be used in the differential diagnosis of asthma and COPD. Eighty-four patients (male/female: 32/52; mean age 50.2 ± 12.7 years) with obstructive lung disease and 30 healthy volunteers as the control group were enrolled in the study. The patients were divided into two groups as COPD and asthma and also smoking subgroups. Alveolar clearance study was performed using a radiolabeled aerosol of (99m) Tc-DTPA. Mucociliary clearance was evaluated with T½ , cap value and penetration index parameters. All patient underwent pulmonary function tests and Forced expiratory volume (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC parameters were obtained. The mean of T½ values of (99m) Tc-DTPA aerosol and FEV1 /FVC value among spirometric tests of the nonsmoking COPD patients were significantly lower than nonsmoking asthma patients (46.1 ± 14.3, 62.3 ± 18.7, P = 0.02; 65.2 ± 10.8, 81.4 ± 16.5, P = 0.04, respectively). The cap value was significantly higher in nonsmoking COPD patients (1.21 ± 0.49, 0.76 ± 0.22, P = 0.03). While there were no statistically and significantly different between control and asthmatic groups at the scintigraphic parameters and spirometric parameters, the mean of T½ values, cap value and spirometric parameters were statistically different between control and COPD groups (P scintigraphy was a useful, easy to apply and a noninvasive technique to use in the differential diagnosis of nonsmoker COPD and asthma. © 2014 John Wiley & Sons Ltd.

  14. Diagnosis of splenosis: The advantages of splenic scintiscanning with TC 99m heat-damaged red blood cells. Case report

    Energy Technology Data Exchange (ETDEWEB)

    Bidet, A.C.; Bidet, R.; Mas, J.; Dreyfus-Schmidt, G.; Combe, J.; Milleret, P.

    1986-10-01

    We present one case of peritoneal splenosis, which was not confirmed by the splenic scintiscan with /sup 99m/Tc-sulphur colloid, but whose diagnosis, carried out during a second scintiscan with /sup 99m/Tc-heat-damaged RBC, was confirmed by laparotomy and histology. This case confirms that, for the diagnosis of splenosis, heat-damaged RBC scintigraphy must be used rather than either sulphur colloid scintigraphy or computed-tomography.

  15. Cerebral blood flow SPECT with Tc-99m exametazine correlates in AIDS dementia complex stages. A preliminary report.

    Science.gov (United States)

    Ajmani, A; Habte-Gabr, E; Zarr, M; Jayabalan, V; Dandala, S

    1991-09-01

    Human immunodeficiency virus (HIV) infection is frequently complicated by a variety of disease processes affecting the central nervous system (CNS). One of them is AIDS dementia complex (ADC), which, in the absence of opportunistic infection, is believed to be caused by HIV itself. ADC is characterized by a constellation of cognitive, motor, and behavioral symptoms that progressively get worse. This study was coined to recruit AIDS patients without any opportunistic CNS infection but with signs of CNS abnormality as evidenced by behavioral and subtle motor changes, then to categorize them into five stages, and finally to perform the cerebral blood flow scan using Ceretec. The aim of this study was to correlate the abnormalities of the brain scan with the different stages of ADC. Five patients were analyzed, with dementias ranging from mild to severe according to Price's classification. After confirming the absence of CNS opportunistic infections and AIDS associated malignancies by CT of the brain, the patients underwent psychiatric evaluation and brain scans. The SPECT scans were very sensitive in showing uptake defects in the brain, even in the early stages of ADC. The blood flow defects were more pronounced in the later stages, while the CT scans remained negative except in patients with the most severe dementia.

  16. Thoraco-Abdominal Duplication Cyst- Role Tc-99m Pertechnetate SPECT-CT Scintigraphy in Localising Ectopic Gastric Mucosa

    Science.gov (United States)

    Ravina, Mudalsha; Datta, Deepanksha; Rangan, Kasturi; Suraj, Ajay Singh; Gambhir, Sanjay

    2017-01-01

    Thoraco-abdominal duplication cyst, a congenital malformation of the posterior primitive foregut rarely presents with anaemia. Ectopic gastric mucosa is seen in around 20%-30% of the enteric duplication cysts. We report the scintigraphic findings of one such case which helped in final diagnosis and management of the patient.

  17. Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn-pyrophosphate

    Directory of Open Access Journals (Sweden)

    JURIJ L. VUCINA

    1999-05-01

    Full Text Available The in vitro stability of 99mTc(Sn-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of 99mTc in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of 99mTc-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq 99mTc/ml but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 µg/ml keeps the content of 99mTc-pertechnetate below 1% during six hours after labeling, even in solutions of high readioactive concentrations (740-814 MBq/ml. Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of 99mTc-pertechnetate below 5% during six hours.

  18. Tc-99m labeled leukocyte scintigraphy and CT for the evaluation of patients with inflammatory bowel disease

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, Chihoko; Kubo, Kohzoh; Aoyama, Hidefumi; Endoh, Hideho; Odashima, Yae; Saitoh, Eri [Sapporo City General Hospital (Japan)

    1997-06-01

    Seventeen cases of inflammatory bowel disease (IBD) were studied to define the intensity and extent of disease by {sup 99m}Tc-HMPAO-labeled leukocytes scintigraphy (TLLS), and 10 cases underwent CT examination to evaluate the bowel wall, lymph-nodes, and mesenteric surroundings. Serial TLLS were obtained up to 4 hours and CT was carried out within one week before or after TLLS. The sensitivities to early and delayed TLLS were 91% and 100%, respectively. The respective specificities were 100% and 33%. However, it appeared that mild IBD may yield false negative results in early TLLS while nonspecific bowel activity and migration of white cells may cause false positive results in delayed imaging. By setting the diagnostic criteria for labeled leukocyte accumulation on visualization of the small bowel regardless of uptake or activity of the large bowel similar to or greater than lumbar bone marrow, the sensitivity and specificity of delayed TLLS changed to 91% and 83%, respectively. On CT examination, mesenteric lymph-node swelling, periintestinal blurring and dilatation of mesenteric vasa recta were observed in all five patients with active Crohn`s disease, while wall thickening and enhancement were seen in four of them. None of the other three cases of inflammatory disease showed positive findings of dilatation of the mesenteric vasa recta, and they revealed relatively low uptake of labeled leukocytes in TLLS. A `scintigram score` was calculated by comparing uptake of tracer in five bowel segments with lumbar bone marrow activity, and a `CT score` was calculated by adding abnormalities of the intestine and mesenteric surroundings. The scintigram score correlated closely with CT score and clinical disease activity. (K.H.)

  19. The findings of Tc-99m ECD brain perfusion SPECT in the patients with left anterior thalamic infarction

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Y. A.; Kim, S. H.; Sohn, H. S.; Jeong, S. G. [The Catholic University of Korea, Seoul (Korea, Republic of)

    2005-07-01

    The thalamus has multiple connections with areas of the cerebral cortex involved in arousal and cognition. Thalamic damage has been reported to be associated with variable neuropsychological dysfunctions and dementia. This study evaluates the changes of regional cerebral blood flow (rCBF) by using SPM analysis of brain perfusion SPECT and examining the neuropsychological abnormalities of 4 patients with anterior thalamic infarctions. Four patients with left anterior thalamic infarctions and eleven normal controls were evaluated. K-MMSE and the Seoul Neuropsychological Screening Battery were performed within 2 days after stroke. The normalized SPECT data of 4 patients were compared to those of 11 controls for the detection of areas with decreased rCBF by SPM analysis. All 4 patients showed anterograde amnesia in their verbal memory, which was not improved by recognition. Dysexecutive features were occasionally present, such as decreased word fluency and impaired Stroop test results. SPM analysis revealed decreased rCBF in the left supra marginal gyrus, the superior temporal gyrus, the middle and inferior frontal gyrus, the medial dorsal and anterior nucleus of the left thalamus. The changes of rCBF in patients with left anterior thalamic infarctions may be due to the remote suppression on metabolism by the interruption of the cortico-subcortical circuit, which connects the anterior thalamic nucleus and various cortical areas. The executive dysfunction and dysnomia may be caused by the left dorsolateral frontal dysfunction of the thalamo-cortical circuit. Anterograde amnesia with storage deficit may be caused by the disruption of mamillothalamic tract.

  20. Prediction of response to revascularization in patients with renal artery stenosis by Tc-99m-ethylene dicysteine captopril scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Ugur, O.; Ergun, E.L.; Peksoy, I.; Cekirge, S. [Hacettepe Univ., Ankara (Turkey). Medical School; Serdengecti, M.; Karacalioglu, O.

    1999-04-01

    The aim of the present study was to assess the predictive value of captopril scintigraphy with the new renal agent {sup 99m}Tc-ethylene dicysteine ({sup 99m}Tc-EC) for post-interventional improvement in blood pressure. Twelve patients who had persistently high blood pressure with previous demonstration of various degrees of renal artery lesion on angiography were included into the study. Baseline and captopril scintigraphies were performed on the same day at 4 hour intervals after the injection of 74 and 296 MBq of {sup 99m}Tc-EC, respectively. All patients had percutaneous transluminal angioplasty (PTA), and improvement in blood pressure was evaluated 3-6 months after the intervention. {sup 99m}Tc-EC captopril scintigraphy successfully predicted a positive or negative outcome in 11 of 12 patients. In one patient with captopril induced renal function deterioration, scintigraphy failed to predict post-interventional response. Our preliminary findings showed that {sup 99m}Tc-EC captopril scintigraphy can be used to determine patients who will benefit from revascularization. (author)

  1. Biologic gastric emptying time in diabetic patients, using Tc-99m-labeled resin-oatmeal with and without metoclopramide.

    Science.gov (United States)

    Domstad, P A; Kim, E E; Coupal, J J; Beihn, R; Yonts, S; Choy, Y C; Mandelstam, P; DeLand, F H

    1980-11-01

    Biologic gastric emptying time (BGET) was measured in 24 patients with severe diabetes mellitus complicated by vascular damage and peripheral or sensory neuropathy. This population had a BGET of 192 +/- 32.9 min (mean +/- s.e.m. normal 40-85 min). Patients with diabetic gastroenteropathy had prolongation of BGET to 295 +/- 45 (p oatmeal test meal used as described in this study provides a reliable measure of BGET and of the response to metoclopramide.

  2. Synthesis and optical activity of isosorbide chiral derivative containing fluorocarbon group as chiral dopant in liquid crystal materials

    Institute of Scientific and Technical Information of China (English)

    Kong Liang Xie; Yin He Su; Chun Xiang Zhang

    2011-01-01

    Novel isosorbide derivative containing perfluorocarbon group, bi(perfluorooctanesulfonyl)isosorbide ester as chiral dopant in liquid crystal, was synthesized. Chemical structure was characterized by elemental analysis, FT-IR, 1H NMR and 19F NMR. The optical texture of the mixture was observed by polarized optical microscopy (POM). Novel chiral dopant containing perfluorocarbon group had excellent optical activity. Its specific rotation and molar rotation were noticeable higher than those of bi(4-chloromethylbenzenecarbonic)isosorbide ester. The fluorocarbon group improved the molar rotation of chiral compound and did not affect optical rotation direction. The texture of the mixture added isosorbide derivative with fluorocarbon group showed the oily streak texture.

  3. Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices

    DEFF Research Database (Denmark)

    Gluud, Lise Lotte; Langholz, Ebbe; Krag, Aleksander Ahm

    2010-01-01

    The evidence concerning the use of isosorbide-mononitrate (IsMn) for oesophageal varices is equivocal.......The evidence concerning the use of isosorbide-mononitrate (IsMn) for oesophageal varices is equivocal....

  4. Selective Dehydration of Sorbitol to Isosorbide over Sulfonated Activated Carbon Catalyst

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyo Yoon; Hwang, Dong Won; Hwang, Young Kyu; Hwang, Jin-Soo; Chang, Jong-San [Korea Research Institute of Chemical Technology (KRICT), Daejeon (Korea, Republic of)

    2013-04-15

    A sulfonated activated carbon (AC-SO{sub 3}H) was used as a solid acid catalyst for dehydration of sorbitol to isosorbide and its catalytic performance was compared with the commercial solid acid such as acidic ion exchange resin, Amberlyst-36, and sulfated copper oxide. The catalytic performance with 100% sorbitol conversion and 52% isosorbide selectivity was obtained over AC-SO{sub 3}H at 423.15 K. Although AC-SO{sub 3}H possessed only 0.5 mmol/g of sulfur content, it showed the similar dehydration activity of sorbitol to isosorbide with Amberlyst-36 (5.4 mmol/g) at 423.15 K. Based on the high thermal and chemical stability of AC-SO{sub 3}H, one-step reactive distillation, where isosorbide separation can be carried out simultaneously with sorbitol dehydration, was tried to increase the recovery yield of isosorbide from sorbitol. The reactive distillation process using AC-SO{sub 3}H, the turnover number of AC-SO{sub 3}H was 4 times higher than the conventional two-step process using sulfuric acid.

  5. Thermal and mechanical properties of polylactic acid (PLA) and bagasse carboxymethyl cellulose (CMCB) composite by adding isosorbide diesters

    Science.gov (United States)

    Kamthai, Suthaphat; Magaraphan, Rathanawan

    2015-05-01

    An isosorbide diesters is one of isororbide types used as a plasticizer. The influence of this plasticizer on thermal and mechanical properties of polylactic acid and bagasse carboxymethyl cellulose (PLA/CMCB) composites was studied. PLA was blended with CMCB at 1%wt using various contents of isosorbide diesters (5, 10, 15 and 20%wt of PLA). The differential scanning calorimetric (DSC) and thermogravimetric (TGA) analyses indicated that the increment of isosorbide diesters concentration resulted in decreasing glass transition, melting and decomposition temperatures, as well as the reduction of storage modulus of PLA/CMCB composites. Moreover, the elongation of PLA/CMCB composites was significantly improved with increasing plasticizer content.

  6. Co- and Terpolyesters based on isosorbide and succinic acid for coating applications : synthesis and characterization

    NARCIS (Netherlands)

    Noordover, B.A.J.; Staalduinen, van V.G.; Duchateau, R.; Koning, C.E.; Benthem, van R.A.T.M.; Mak, M.; Heise, A.; Frissen, A.E.; Haveren, van J.

    2006-01-01

    Co- and terpolyesters based on succinic acid and isosorbide in combination with other renewable monomers such as 2,3-butanediol, 1,3-propanediol, and citric acid were synthesized and characterized. Linear polyesters were obtained via melt polycondensation of nonactivated dicarboxylic acids with OH f

  7. The neighboring effect of isosorbide and its epimers in their reactions with dimethyl carbonate

    Directory of Open Access Journals (Sweden)

    Fabio Aricò

    2014-10-01

    Full Text Available The reactions of isosorbide and its epimers, isomannide and isoidide, with dimethyl carbonate have been herein investigated as easy access to bio-based products by a free-halogen chemistry approach. Isosorbide and its epimers show a different reactivity in bimolecular nucleophilic substitution with dimethyl carbonate (DMC. Carboxymethylation reaction was carried out in the presence of DMC and a weak base resulting in the high-yielding synthesis of dicarboxymethyl derivatives. Isomannide was the most reactive anydro sugar due to the less sterically hindered exo position of the OH groups. On the other hand, methylation of isosorbide and its epimers, conducted in the presence of a strong base and DMC, showed the higher reactivity of the endo hydroxyl group, isoidide being the most reactive epimer. This result has been ascribed to the neighboring effect due to the combination of the oxygen in β-position and the intramolecular hydrogen bond within the anhydro sugar structure. Methylation reactions were also conducted in autoclave at high temperature with the amphoteric catalyst hydrotalcite using DMC as reagent and solvent. In this case, the reactivity of the epimers resulted quite differently with isosorbide being the most reactive reagent possibly as a result of the structure of hydrotalcite comprising of both acidic and basic sites. The neighboring effect was observed with good evidence in these methylation reactions.

  8. Isosorbide, a green plasticizer for thermoplastic starch that does not retrogradate.

    Science.gov (United States)

    Battegazzore, Daniele; Bocchini, Sergio; Nicola, Gabriele; Martini, Eligio; Frache, Alberto

    2015-03-30

    Isosorbide is a non-toxic biodegradable diol derived from bio-based feedstock. It can be used for preparing thermoplastic starch through a semi-industrial process of extrusion. Isosorbide allows some technological advantages with respect to classical plasticizers: namely, direct mixing with starch, energy savings for the low processing temperature required and lower water uptake. Indeed, maize starch was directly mixed with the solid plasticizer and direct fed in the main hopper of a co-rotating twin screw extruder. Starch plasticization was assessed by X-ray diffraction (XRD) and dynamic-mechanical analysis (DMTA). Oxygen permeability, water uptake and mechanical properties were measured at different relative humidity (R.H.) values. These three properties turned out to be highly depending on the R.H. No retrogradation and changing of the material properties were occurred from XRD and DMTA after 9 months.

  9. Conversion of cellulose into isosorbide over bifunctional ruthenium nanoparticles supported on niobium phosphate.

    Science.gov (United States)

    Sun, Peng; Long, Xiangdong; He, Hao; Xia, Chungu; Li, Fuwei

    2013-11-01

    Considerable effort has been applied to the development of new processes and catalysts for cellulose conversion to valuable platform chemicals. Isosorbide is among the most interesting products as it can be applied as a monomer and building block for the future replacement of fossil resource-based products. A sustainable method of isosorbide production from cellulose is presented in this work. The strategy relies on a bifunctional Ru catalyst supported on mesoporous niobium phosphate in a H2 atmosphere under pressure without further addition of any soluble acid. Over 50 % yield of isosorbide with almost 100 % cellulose conversion can be obtained in 1 h. The large surface area, pore size, and strong acidity of mesoporous niobium phosphate promote the hydrolysis of cellulose and dehydration of sorbitol; additionally, the appropriate size of the supported Ru nanoparticles avoids unnecessary hydrogenolysis of sorbitol. Under a cellulose/catalyst mass ratio of 43.3, the present bifunctional catalyst could be stably used up to six times, with its mesoporous structure well preserved and without detectable Ru leaching into the reaction solution.

  10. Fatal Intoxications Due to Administration of Isosorbide Tablets Contaminated with Pyrimethamine.

    Science.gov (United States)

    Imran, Muhammad; Shafi, Humera; Mahmood, Zahid; Sarwar, Mohammad; Usman, Hafiz Faisal; Tahir, Mohammad Ashraf; Ashiq, Muhammad Zar

    2016-09-01

    In January 2012, 664 cases of pyrimethamine toxicity and 151 deaths were reported among cardiac patients that had recently received free medicines from pharmacy of Punjab Institute of Cardiology, Lahore, Pakistan. These patients, ages ranged from 58 to 75 years, were prescribed simvastatin, clopidogrel, aspirin soluble, isosorbide mononitrate, and amlodipine. On examination of medications being given to them, it was found that a particular batch of isosorbide mononitrate tablets was contaminated with 50 mg pyrimethamine. Cardiac patients were taking isosorbide contaminated with pyrimethamine twice daily (100 mg pyrimethamine/day), whereas therapeutic dose of pyrimethamine for malaria is 25 mg/week. Postmortem urine, cardiac blood, and femoral blood specimens of three deceased males were submitted to author's laboratory for analysis. Postmortem toxicological analysis revealed that pyrimethamine concentration fell within the range of 1-10 μg/mL by liquid chromatography. Clinical, autopsy, histopathological, and toxicological findings strongly suggested toxicity due to pyrimethamine accumulation that resulted in deaths of these cardiac patients.

  11. Is Imaging Time Between two Tc 99m DMSA Scans Sufficient for Reporting as Renal Parenchymal Scarring? Healed Parenchymal Renal Defect After 6 Years

    Directory of Open Access Journals (Sweden)

    Erdem Sürücü

    2013-04-01

    Full Text Available We aimed to report a healed renal parenchymal defect after 6 years in a 9-year-old girl who was being followed for recurrent urinary tract infection (UTI. The first UTI was at the age of two. She was being followed with ultrasonography, urine analysis and urine culture since the first UTI. Technetium-99m dimercaptosuccinic acid (DMSA scintigraphy was repeated four times up to the present day. She had a renal parenchymal defect reported as parenchymal scarring, which healed 6 years after the first DMSA scintigraphy.

  12. Tc-99m-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours

    NARCIS (Netherlands)

    Bakker, M; Van der Graaf, WTA; Piers, DA; Franssen, EJF; Groen, HJM; Smit, EF; Kool, W; Hollema, H; Muller, EA; de Vries, EGE

    1999-01-01

    Background: Our aim was to determine the value of 99mTc-Sestamibi scanning as functional detection method of P-glycoprotein (Pgp) blockade by PSC 833 in solid tumour patients. Patients and methods: Day 1 and day 4 after 2,200 mg orally administered PSC 833 the tumour area was scanned after intraveno

  13. Value of I-123-subtraction and single-photon emission computed tomography in addition to planar Tc-99m-MIBI scintigraphy before parathyroid surgery

    NARCIS (Netherlands)

    Jorna, Francisca H.; Jager, Pieter L.; Que, Tjin H.; Lemstra, Clara; Plukker, John T. M.

    2007-01-01

    Purpose. To find out if single-photon emission computed tomography (SPECT) and I-123-subtraction can enhance the findings of Tc-99-methoxyisobutylisonitrile (MIBI) scintigraphy for the preoperative localization of parathyroid (PT) tumors. Methods. Among the 111 consecutive patients who underwent pre

  14. [Diagnostic possibilities of static gamma-scintigraphy using 99mTc pyrophosphate and Tc 99m phosphate in children with glomerulo nephritis].

    Science.gov (United States)

    Mil'ko, V I; Bagdasarova, I V; Moskalenko, N I; Ivanov, D D

    1989-01-01

    Children with nephrotic glomerulonephritis were examined for incorporation of 99mTc-pyrophosphate and 99mTc-phosphone. The relationship was discovered between the accumulation of the radiopharmaceutical drug and the sensitivity to glucocorticoids used in the pathogenetic treatment. Accumulation of the drug in the course of the treatment documents the presence of complete, partial remission or the disease activity. It is recommended that static gammascintigraphy should be carried out for early assessment of the efficacy of the treatment and its correction.

  15. Is femoral uptake of Tc99m-methylene diphosphonate on bone scintigraphy in bronchogenic carcinoma an alarming sign: A case report and brief review of literature?

    Directory of Open Access Journals (Sweden)

    Rayamajhi Sampanna Jung

    2014-01-01

    Full Text Available Detection of skeletal metastasis in patients with lung cancer is important from management point of view. We report the bone scan finding in a patient with non-small cell lung carcinoma showing isolated abnormal tracer in femur and having a characteristic appearance in computed tomography, highlighting the importance of bone scan in patients with bronchogenic carcinoma.

  16. [Anarthria, progressive apraxia and extrapyramidal syndrome: an uncommon clinical form of corticobasal degeneration? A case studied by HMPAO Tc99m single-photon emission tomography].

    Science.gov (United States)

    Fayet, G; Vercelletto, M; Bertout, C; De Kersaint-Gilly, A; Fève, J R

    1995-04-01

    A 48-year-old man presented with impaired joint movement and buccofacial apraxia. The disease progressed for six years associating an akineto-hypertonic syndrome, marked anarthria, saliva incontinence, bi-opercular syndrome, bucco-facial apraxia, severe global gestual apraxia and a frontal syndrom. Oculo-motricity and gait were normal. Magnetic resonance imaging of the brain demonstrated fronto-parietal atrophy and HMPAO Tc99 tomography revealed hypoperfusion of the cortex clearly predominating in the left parietal region. These particular findings with predominantly intense joint involvement is similar to the clinical picture in corticobasal degeneration--subcortical signs (progressively uncontrollable hypertonia) together with cortical signs (severe gestual apraxia). The neuroradiological imaging and functional results also suggest a degenerative process.

  17. Photopenia of the femoral head on 3 phase bone scan using Tc-99m MDP with acute irritable hip in the preschool children: comparison with MR findings

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Young Hoon; Lee, Jong Doo; Yoon, Choon Sik; Suh, Jin Suck; Jeon, Tae Joo [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    1998-07-01

    The child with acute irritable hip is always a diagnostic challenge. Photopenia of femur head is described in Legg-Calve-Perthes disease (LCP). However, it can be seen in cases of septic arthritis (SA) with interruption of vascular supply. Despites being uncommon, recognition of SA as a cause of photopenia is important and requires urgent referral to decompression and drainage. This study was to evaluate causes and scintigraphic features of photopenia of femur head in patients with acute irritable hip and to correlate them with MR findings. 15 patients with acute irritable hip showed photopenia of femur head on bone scan were included. Mean age was 5.3 yrs ( 9 months to 8 yrs). There were 9 patients with LCP and 3 with septic arthritis combined with osteomyelitis. All parents underwent 3 phase bone scan and hip MRI within 2 days interval. Patterns of photopenia of femur head was divided into partial, complete and extending to the metaphysis. All patients with LCP showed partial photopenia confined to femur epiphysis. Whereas, 1 with septic arthritis demonstrated complete photopenia of femur head and in 2 with septic arthritis and 3 with septic arthritis combined with osteomyelitis revealed complete photopenia of femur head extending to the metaphyseal area. In cases with septic arthritis, increased uptake affecting both sides of hip joint except for photopenic area is also noted. On MRI, all patients with LCP showed abnormalities confined to the epiphysis. In cases with septic arthritis, abnormalities are not confined to the epiphysis and marrow edema and joint effusion were also noted. In evaluating photopenia of the femur head, it would be helpful to distinguish between the photopenia localized to the femoral epiphysis as seen in cases of LCP and complete photopenia of femur head with extension to the metaphysis as seen in cases of septic arthritis. Recognition of complete with extension to the metaphysis help guide urgent proper management of septic arthritis.

  18. Prognostic value of Tc-99m tetrofosmin myocardial perfusion gated SPECT in patients with diabetes mellitus and suspected coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Marcia Maria Sales dos; Pantoja, Mauricio da Rocha; Cwajg, Eduardo [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil); CINTILAB, Rio de Janeiro, RJ (Brazil); E-mail: mmsales@oi.com.br

    2008-01-15

    Background: The cardiovascular disease is the main cause of death among diabetic patients, which makes it crucial to identify the individuals at higher risk of cardiovascular events. Objective: To evaluate the prognostic value of scintigraphy with gated single photon emission computed tomography (SPECT) in patients with diabetes mellitus (DM) and suspected coronary artery disease. Methods: Retrospective study with 232 diabetic patients submitted to scintigraphy with gated SPECT. Perfusion Gated SPECT (scores and number of altered segments) as well as ventricular function parameters (ejection fraction, left ventricle volume and contractility) were evaluated. Cardiac death, acute ischemic coronary syndrome, revascularization procedures or encephalic vascular accident were considered future cardiovascular events. The uni- and multivariate analyses were carried out by the multiple logistic regression model (p< 0.05). Results: At the univariate analysis, age (p=0.02), chest angina (p=0.01), insulin therapy (p=0.02), myocardial perfusion abnormalities (p<0.0001), the number of segments involved (p=0.0001), the perfusion scores (p=0.0001), the ejection fraction (p=0.004), the final systolic volume (p=0.03) and the finding of segmental alteration at the LV contractility (p<0.0001) were associated with future events at the univariate analysis. At the multivariate analysis, the male sex (p=0.007), age (p=0.03), angina (p=0.001), insulin therapy (p=0.007) and the SDS {>=} 3 (p=0.0001), and the number of altered segments {>=} 3 (p=0.0001) were predictors of cardiovascular events. Conclusion: The myocardial scintigraphy with gated SPECT adds independent information to the stratification of the risk of future cardiovascular events in patients with DM and suspected coronary artery disease. (author)

  19. 用99mTc-MIBI进行鼻咽癌显像的临床研究%Detection of nasopharyngeal carcinoma with Tc-99m MIBI

    Institute of Scientific and Technical Information of China (English)

    杜建强; 裴庆华; 岳殿超; 曾世荃

    2004-01-01

    Objective It is difficult to differentiate primary and recurrent nasopharyngeal carcinoma (NPC). Using 99mTc MIBI scintigraphy, we study patients with NPC in order to determine the efticacy of 99mTc MIBI scintigraphy in detecting the primary, recurrent and metastatic tumors. Method NPC patients were divided into two groups, primary (n= 43) and recurrent (n= 17). 99mTc MIBI SPECT study of head and neck and whole body scan to detect the primary, recurrent and metastases foci were performed on both groups as well as on volunteers (n = 21). Comparing with the scalp, the uptakes on the nasopharynx were divided into 5 grades, assessed by 3 physicians independently without any clinical information. Results In the primary NPC group, 36 patients were positive and 5 were negative. 13 patients had metastases in neck lymph nodes and 2 had lungs metastases. The specificity was 90.5 % ( 19 of 21) and the sensitivity was 82.7 % (36 of 43 ). In the recurrent group, 13 patients were positive, and 4 were negative. The sensitivity was 76.5 % ( 13 of 17 ). Conclusion This study suggests that 99mTc MIBI SPECT is a useful method for detecting NPC with particular potential value in diagnosis of recurrent NPC.%目的在临床上,鼻咽癌复发的诊断是非常困难的,我们用99mTc-MIBI来探索鼻咽癌的原发灶、复发灶和转移灶的诊断.方法用99mTc-MIBI断层显像检测21例对照组和41例治疗前鼻咽癌病例,病灶的放射性摄取与头皮比较,由3名以上的医师在不知道任何临床情况下分别阅片.结果41例治疗前鼻咽癌病例中共有36例阳性,特异性为90.5%,灵敏度为83.7%.结论99mTc-MIBI显像对鼻咽癌原发灶和转移灶的诊断,是一种灵敏的方法,值得进一步探讨.

  20. Effect of the reverse redistribution pattern on the left ventricular ejection fraction in the Tc- 99m MIBI SPECT myocardial perfusion scintigraphy

    Directory of Open Access Journals (Sweden)

    Bekir Taşdemir

    2015-09-01

    Full Text Available Objective: The causes and prognostic significance of the reverse redistribution pattern (RRP is not clear yet. In this study, we aimed to evaluate the RRP effect on the left ventricular ejection fraction (EF. Methods: Imaging of the patients whose technetium-99m sestamibi myocardial perfusion scintigraphy was carried out and reported as normal were retrospectively examined. One-day protocol and/or pharmacologic stress testing applied patients were excluded. 21 patients with RRP met the inclusion criteria. All of these patients were included in the study as RRP group. Randomly selected 21 patients with non-RRP were included in the study as control group. Transient ischemic dilation (TID scores and EF values were automatically calculated with the Quantitative Gated SPECT (QGS program. Results: While a statistically significant difference was not found between the RRP and control groups in terms of age, sex, hypertension, family history, hyperlipidemia, and diabetes (p>0.05, there was a statistically significant difference in terms of smoking (p=0.019. TID scores in the RRP group were significantly lower compared to the control group (p<0.001. In addition, a statistically significant decrease was determined in the EF values in the rest images compared to the stress images in the RRP group (p=0.002. Furthermore, this decrease was significantly higher than in the control group (p= 0.034. Conclusion: The results related to the TID scores and EF values are suggesting the existence of an ischemic cause in the background of the RRP. Additionally, the relationship found between smoking and RRP may be associated with the tachycardia and / or coronary spasm-inducing effect of smoking. J Clin Exp Invest 2015; 6 (3: 286-290

  1. Synthesis and initial biological evaluation of a novel Tc-99m radioligand as a potential agent for 5-HT1A receptor imaging

    Energy Technology Data Exchange (ETDEWEB)

    Abdelounis, Najoua Mejri; Saied, Nadia Malek; Essouissi, Imen; Guizani, Sihem; Saidi, Mouldi [CNSTN, Sidi Thabet (Tunisia). Research Unit of Medical, Agricultural and Environmental Use of Nuclear Applications

    2014-09-01

    The synthesis, characterization and biological evaluation of N-Tolueneferrocenecarboxamide labeled with technetium-99m ({sup 99m}Tc-TTCC) is reported. Biological studies in Wistar rats showed the ability of {sup 99m}Tc-TPCC to cross the intact blood-brain barrier. In vivo biodistribution indicated that this complex had good brain uptake (1.32%ID/g at 5 min and 0.64%ID/g at 60 min) and good retention (about 50% of the activity was retained in the brain at 60 min post-injection). Regional brain distribution study showed that hippocampus, where the 5-HT1A receptor density is high, had the highest uptake (0.73%ID/g at 5 min p.i.) and the cerebellum, where the 5-HT1A receptor density is low, had the lowest uptake (0.12%ID/gID/g at 5 min p.i.). After blocking with 8-hydroxy-2-(dipropylamino) tetralin, the uptake of hippocampus was decreased significantly from 0.73%ID/g to 0.20%ID/g at 5 min p.i., while the cerebellum had no significant decrease. This result indicates that 99mTc complex has specific binding to 5-HT1A receptor. (orig.)

  2. Bone Scan "Hot Spot" at the Superior Lateral Orbital Margin Fronto-zygomatic Suture Uptake Characterized with Tc-99m MDP SPECT/CT.

    Science.gov (United States)

    Thang, S P; Tan, A E H; Goh, A S W

    2011-07-01

    Findings of a solitary "hot spot" at the superior lateral orbital margin on bone scan scintigraphy is not uncommonly seen, and is often dismissed as a benign lesion. However, the exact etiology is indeterminate. We present two cases in which hybrid single photon emission computed tomography/computed tomography imaging was able to characterize and localize this uptake, demonstrating correlation to the right fronto-zygomatic suture.

  3. Simultaneous Tc-99m/I-123 dual-radionuclide myocardial perfusion/innervation imaging using Siemens IQ-SPECT with SMARTZOOM collimator

    Science.gov (United States)

    Du, Yong; Bhattacharya, Manojeet; Frey, Eric C.

    2014-06-01

    Simultaneous dual-radionuclide myocardial perfusion/innervation SPECT imaging can provide important information about the mismatch between scar tissue and denervated regions. The Siemens IQ-SPECT system developed for cardiac imaging uses a multifocal SMARTZOOM collimator to achieve a four-fold sensitivity for the cardiac region, compared to a typical parallel-hole low-energy high-resolution collimator, but without the data truncation that can result with conventional converging-beam collimators. The increased sensitivity allows shorter image acquisition times or reduced patient dose, making IQ-SPECT ideal for simultaneous dual-radionuclide SPECT, where reduced administrated activity is desirable in order to reduce patient radiation exposure. However, crosstalk is a major factor affecting the image quality in dual-radionuclide imaging. In this work we developed a model-based method that can estimate and compensate for the crosstalk in IQ-SPECT data. The crosstalk model takes into account interactions in the object and collimator-detector system. Scatter in the object was modeled using the effective source scatter estimation technique (ESSE), previously developed to model scatter with parallel-hole collimators. The geometric collimator-detector response was analytically modeled in the IQ-SPECT projector. The estimated crosstalk was then compensated for in an iterative reconstruction process. The new method was validated with data from both Monte Carlo simulations and physical phantom experiments. The results showed that the estimated crosstalk was in good agreement with simulated and measured results. After model-based compensation the images from simultaneous dual-radionuclide acquisitions were similar in quality to those from single-radionuclide acquisitions that did not have crosstalk contamination. The proposed model-based method can be used to improve simultaneous dual-radionuclide images acquired using IQ-SPECT. This work also demonstrates that ESSE scatter modeling can be applied to non-parallel-beam projection geometries.

  4. Simultaneous Tc-99m/I-123 Dual Radionuclide Myocardial Perfusion/Innervation Imaging Using Siemens IQ-SPECT with SMARTZOOM Collimator

    Science.gov (United States)

    Du, Yong; Bhattacharya, Manojeet; Frey, Eric. C.

    2014-01-01

    Simultaneous dual-radionuclide myocardial perfusion/innervation SPECT imaging can provide important information about mismatch between scar tissue and denervated regions. The Siemens IQ-SPECT system developed for cardiac imaging uses a multifocal SMARTZOOM collimator to achieve a four-fold sensitivity for the cardiac region compared to a typical parallel-hole low-energy high-resolution collimator but without the data truncation that can result with conventional converging-beam collimators. The increased sensitivity allows shorter image acquisition times or reduced patient dose, making IQ-SPECT ideal for simultaneous dual-radionuclide SPECT, where reduced administrated activity is desirable in order to reduce patient radiation exposure. However, crosstalk is a major factor affecting the image quality in dual-radionuclide imaging. In this work we developed a model-based method that can estimate and compensate for the crosstalk in IQ-SPECT data. The crosstalk model takes into account interactions in the object and collimator-detector system. Scatter in the object was modeled using the effective source scatter estimation technique (ESSE), previously developed to model scatter with parallel-hole collimators. The geometric collimator detector response was analytically modeled in the IQ-SPECT projector. The estimated crosstalk was then compensated for in an iterative reconstruction process. The new method was validated with data from both Monte Carlo simulation and physical phantom experiments. The results showed that the estimated crosstalk was in good agreement with simulated and measured results. After model-based compensation the images from simultaneous dual-radionuclide acquisitions were similar in quality to those from single radionuclide acquisitions that did not have crosstalk contamination. The proposed model-based method can be used to improve simultaneous dual-radionuclide images acquired using IQ-SPECT. This work also demonstrates that ESSE scatter modeling can be applied to non-parallel-beam projection geometries. PMID:24819280

  5. Simultaneous Tc-99m/I-123 Dual Radionuclide Myocardial Perfusion/Innervation Imaging Using Siemens IQ-SPECT with SMARTZOOM Collimator

    OpenAIRE

    Du, Yong; Bhattacharya, Manojeet; Frey, Eric C.

    2014-01-01

    Simultaneous dual-radionuclide myocardial perfusion/innervation SPECT imaging can provide important information about mismatch between scar tissue and denervated regions. The Siemens IQ-SPECT system developed for cardiac imaging uses a multifocal SMARTZOOM collimator to achieve a four-fold sensitivity for the cardiac region compared to a typical parallel-hole low-energy high-resolution collimator but without the data truncation that can result with conventional converging-beam collimators. Th...

  6. Evaluation of the effects of methylprednisolone pulse therapy in patients with systemic lupus erythematosus with brain involvement by Tc-99m HMPAO brain SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Sun, S.S.; Kao, C.H. [Department of Nuclear Medicine, China Medical University Hospital, Taichung (Taiwan); Huang, W.S. [Department of Nuclear Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei (Taiwan); Chen, J.J.H. [Section of Rheumatology, Department of Internal Medicine, China Medicine University Hospital, Taichung (Taiwan); Chang, C.P. [Division of Allergy, Immunology and Rheumatology, Changhua Christian Hospital, Changhua (Taiwan); Wang, J.J. [Department of Medical Research, Chi-Mei Medical Center, Tainan (Taiwan)

    2004-07-01

    Methylprednisolone pulse therapy (MPT) was introduced to avoid life-threatening complications in patients with systemic lupus erythematosus (SLE) with brain manifestations; however, the efficacy of MPT in SLE patients with brain involvement is still uncertain and needs to be objectively evaluated. We enrolled 15 female SLE patients with neuropsychiatric manifestations in this study. All patients had normal brain MRI and abnormal brain HMPAO-SPECT findings. Follow-up HMPAO-SPECT studies were conducted 2 weeks after MPT. Serum levels of anticardiolipin antibodies (ACA) and anti-ribosomal P antibodies (anti-P) were measured before and after MPT. Before MPT, 7 patients were positive for ACA and 7 patients were positive for anti-P. After MPT, none of the 15 patients demonstrated positive serologic findings or neuropsychiatric manifestations. Based on the follow up brain HMPAO-SPECT images following MPT, 13 patients showed disappearance of the perfusion defects and 2 patients showed partial recovery of rCBF. Brain HMPAO-SPECT imaging is a logical and objective tool for measuring the effects of MPT in SLE patients with brain involvement by determining of changes in rCBF. (orig.)

  7. Tc-99m-PEG-liposomes target both adhesions and abscesses and their reduction by hyaluronate in rats with fecal peritonitis.

    NARCIS (Netherlands)

    Sikkink, C.J.J.M.; Reijnen, M.M.P.J.; Laverman, P.; Oyen, W.J.G.; Goor, H. van

    2009-01-01

    BACKGROUND: Abdominal adhesions and abscesses are a major source of morbidity and mortality after abdominal surgery and peritonitis. Adhesions are hard to detect with standard imaging techniques. Liposomes, coated with polyethylene glycol (PEG), represent an agent developed for infection imaging. Th

  8. Comparison of renal allograft (AG) biopsy diagnosis and temporal quantitation of Tc-99m sulfur colloid (SC) in clinically suspected AG rejection

    Energy Technology Data Exchange (ETDEWEB)

    George, E.A.; Brown, W.N.; Carney, K.; Naidu, R.G.; Palmer, D.C.

    1984-01-01

    The purpose of this study was to evaluate the diagnostic efficacy of temporal quantitation of SC compared to tissue diagnosis of AG needle biopsy (Bx). The principal clinical criteria for patient selection were sequential or persistent reduction (at least 40-50%) of AG function as determined by serial serum creatinine levels. Thirty-four AG recipients were examined with SC and subsequent AG Bx in 37 instances. %SC AG accumulation and bone marrow extraction were interpreted in view of the significant sequential of persistent reduction of Ag function. Each AG Bx was collected from multiple needle aspirates and processed for light microscopy and immunoflorescent staining. Bx and SC exam were evaluated for acute rejection (AR), chronic rejection (CR) or other, non-rejection pathology. Acute tissue changes superimposed on chronic were regarded as AR. Acute tissue changes and % SC AG accumulation in the rejection range were graded as mild, moderate and marked. In AR there was 28/28 agreement of Bx and SC diagnosis; of which 7/28 were superimposed on CR. In Cr Bx and SC agreed in 3/7 instances, in 3/7 SC Dx was AR and in 1/7 SC exam was normal. Sensitivity and specificity of the SC diagnosis in this series was 100% and 63% for AR, 43% and 100% for CR and 97% and 100% in all instances of rejection. Bx and SC grading of AR agreed in 64%. In conclusion, temporal quantitation of SC demonstrated overall good correlation with AG Bx diagnosis in this series. The poor sensitivity of 43% of SC in Cr and only 64% correlation in grading AR may be due to inherent Bx sampling and SC data analysis error.

  9. Low frequency spin dynamics in the quantum magnet copper pyrazine dinitrate

    Energy Technology Data Exchange (ETDEWEB)

    Kuehne, H.; Klauss, H.H. [Institut fuer Festkoerperphysik, TU Dresden Dresden (Germany); Institut fuer Physik der Kondensierten Materie, TU Braunschweig (Germany); Guenther, M. [Institut fuer Festkoerperphysik, TU Dresden Dresden (Germany); Grossjohann, S.; Brenig, W. [Institut fuer Theoretische Physik, TU Braunschweig (Germany); Litterst, F.J. [Institut fuer Physik der Kondensierten Materie, TU Braunschweig (Germany); Reyes, A.P.; Kuhns, P.L. [National High Magnetic Field Laboratory, Tallahassee, FL (United States); Turnbull, M.M.; Landee, C.P. [Carlson School of Chemistry and Department of Physics, Clark University, Worcester, MA (United States)

    2010-03-15

    The S = 1/2 antiferromagnetic Heisenberg chain exhibits a magnetic field driven quantum critical point. We study the low frequency spin dynamics in copper pyrazine dinitrate (CuPzN), a realization of this model system of quantum magnetism, by means of {sup 13}C-NMR spectroscopy. Measurements of the nuclear spin-lattice relaxation rate T{sub 1}{sup -} {sup 1} in the vicinity of the saturation field are compared with quantum Monte Carlo calculations of the dynamic structure factor. Both show a strong divergence of low energy excitations at temperatures in the quantum regime. The analysis of the anisotropic T{sub 1}{sup -} {sup 1}-rates and frequency shifts allows one to disentangle the contributions from transverse and longitudinal spin fluctuations for a selective study and to determine the transfer of delocalized spin moments from copper to the neighboring nitrogen atoms. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  10. Crystal structure of N,N-diethylbenzene-1,4-diaminium dinitrate

    Directory of Open Access Journals (Sweden)

    Yasmina Bouaoud

    2014-11-01

    Full Text Available In the structure of the title molecular salt, C10H18N22+·2NO3−, the dinitrate salt of 4-(N,N-diethylaminoaniline, the two ethyl groups lie almost perpendicular to the plane of the benzene ring [the ring-to-ethyl C—C—N—C torsion angles are −59.5 (2 and 67.5 (3°]. The aminium groups of the cation form inter-species N—H...O hydrogen bonds with the nitro O-atom acceptors of both anions, giving rise to chain substructures lying along c. The chains are linked via further N—H...O hydrogen bonds, forming two-dimensional networks lying parallel to (010. These sheets are linked by C—H...O hydrogen bonds, forming a three-dimensional structure.

  11. Incorporation of isosorbide into poly(butylene terephthalate) via solid-state polymerization.

    Science.gov (United States)

    Sablong, Rafaël; Duchateau, Robbert; Koning, Cor E; de Wit, Gert; va Es, Daan; Koelewijn, Roelof; van Haveren, Jacco

    2008-11-01

    The biomass-based monomer isosorbide was incorporated into poly(butylene terephthalate) (PBT) by solid-state polymerization (SSP) using the macrodiol monomer BTITB-(OH) 2, which consists of isosorbide (I), terephthalic acid (T), and 1,4-butandiol (B) residues. This macromonomer can be synthesized by a simple one-pot, two-step reaction. Polymers with number-average molecular weights up to 100,000 g x mol (-1) were readily synthesized from various ratios of PBT/BTITB-(OH) 2. Their molecular weights, thermal properties, and colors were compared with corresponding copolyesters that were obtained by melt polycondensation. We found that T m, T c, and especially T g were superior for materials that were obtained by SSP. This is ascribed to differences in the microstructures of both types of copolyesters; the SSP products exhibit a more blocky structure than do the more random melt-polymerized counterparts. The SSP method resulted in much higher molecular weights and much less colored polymers, and it seems to be the preferred route for incorporating biobased monomers that exhibit limited thermal stability into engineering plastics.

  12. New poly(p-phenylenevinylene derivatives containing isosorbide unit in the side-chain

    Directory of Open Access Journals (Sweden)

    H. Zrida

    2014-10-01

    Full Text Available New conjugated PPV derivatives containing the chiral isosorbide group (P1-3 have been synthesized via the Gilch reaction. The polymers are optically active, soluble in common organic solvents and show good film-forming abilities. High number-average molecular weights were determined by size exclusion chromatography (SEC (16•103–21•103 g•mol–1. The molecular structures of the polymers were confirmed by nuclear magnetic resonance (NMR and Fourier transform infrared (FTIR spectroscopies. Thermogravimetric analysis of the polymers showed good thermal stability up to 320°C. The optical properties of these π-conjugated materials were investigated by UV-vis absorption and photoluminescence (PL spectroscopies. The polymers show a yellow fluorescence in dilute solution, and an orange emission is observed in thin films. The introduction of the polar isosorbide groups improved the PL intensity, and quantum yields between 50 and 73% were obtained. The HOMO-LUMO energy levels were estimated by cyclic voltammetry, and the electrochemical gaps were 1.81, 1.83 and 2.48 eV for P1, P2 and P3, respectively. Single-layer diode devices were fabricated and show relatively low turn-on voltages between 3.1 and 3.4 V.

  13. Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate

    DEFF Research Database (Denmark)

    Christiansen, Ingelise; Iversen, Helle Klingenberg; Olesen, Jes

    2008-01-01

    in different cranial arteries over more than 24 h are lacking. We compared the vascular changes of the middle cerebral, superficial temporal and radial arteries during oral administration of isosorbide-5-mononitrate (5-ISMN) 30 mg three times daily for 7 days in 11 healthy subjects in a double...

  14. Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate3

    DEFF Research Database (Denmark)

    Christiansen, I.; Iversen, H.K.; Olesen, Jes

    2008-01-01

    in different cranial arteries over more than 24 h are lacking. We compared the vascular changes of the middle cerebral, superficial temporal and radial arteries during oral administration of isosorbide-5-mononitrate (5-ISMN) 30 mg three times daily for 7 days in 11 healthy subjects in a double...

  15. Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate

    DEFF Research Database (Denmark)

    Iversen, Helle Klingenberg; Nielsen, T H; Garre, K

    1992-01-01

    The aim of the present study was to compare the ability of different doses of isosorbide-5-mononitrate (5-ISMN) to cause dilatation of medium sized and small arteries, and to examine the intensity and duration of any headache produced. Ten healthy volunteers each received 3 doses of 5-ISMN...

  16. Advances in production and application of isosorbide%异山梨醇的制备及应用研究进展

    Institute of Scientific and Technical Information of China (English)

    朱虹; 李春虎; 牟新东

    2011-01-01

    The source, application and preparation method of isosorbide are introduced. Catalysts used for dehydration of sorbitol to prepare isosorbide are described and the current situation of research on the field of isosorbide is reviewed. Isosorbide is widely used in food, cosmetics, medicine, plastic and polymer domains. Isosorbide is considered to be a kind of important bio-based industrial chemical in the coming future. Therefore, it can be seen that dehydration of sorbitol for isosorbide preparation will be studied extensively.%介绍了异山梨醇的来源、用途和制备方法,阐述了由山梨醇脱水制备异山梨醇的催化剂及研究进展.异山梨醇在食品、化妆品、医药、塑料及聚合物等领域有广泛的应用,被誉为未来重要的生物基化工原料,因此深入开展以山梨醇为原料脱水制备异山梨醇的研究具有重要意义.

  17. Evaluation of Isosorbide Mononitrate for Preinduction of Cervical Ripening: A Randomized Placebo-Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Ramya Krishnamurthy

    2015-06-01

    Full Text Available To evaluate the safety and efficacy of Isosorbide mononitrate (IMN as a cervical ripening agent prior to induction of labour in term pregnant women.A randomized placebo-controlled study was conducted on 100 term singleton pregnancies planned for induction of labour. The participants were randomly assigned to two groups. One group received 40 mg IMN and the other group received 40mg of placebo kept vaginally. The main outcome of this study was to evaluate the efficacy of IMN in cervical ripening based on the change in modified Bishop score and the effect on time duration between the drug insertion and delivery. Safety of isosorbide mononitrate was assessed by measuring variables related to maternal and neonatal outcomes.Baseline demographic characteristics were similar in both groups. The mean change in modified Bishop score after 2 doses of 40mg IMN was insignificant when compared to placebo. Though IMN shortened the time duration between the drug insertion to delivery when compared to placebo, it was statistically insignificant. The need for oxytocin and 2(nd ripening agent was less in IMN group when compared to placebo group but statistically this also proved to be insignificant. It was noted that there was an increase in caesarean deliveries in IMN than in placebo group. IMN did not cause any significant change in maternal hemodynamics and adverse side effects. Though NICU admission and stay was less in IMN than in placebo group, it was statistically insignificant.Though IMN did not cause any maternal and neonatal adverse effects, it was found to be inefficient in comparison to placebo as a cervical ripening agent.

  18. Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid

    Energy Technology Data Exchange (ETDEWEB)

    Śmiga-Matuszowicz, Monika, E-mail: monika.smiga-matuszowicz@polsl.pl [Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice (Poland); Janicki, Bartosz; Jaszcz, Katarzyna; Łukaszczyk, Jan [Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice (Poland); Kaczmarek, Marcin [Silesian University of Technology, Department of Biomaterials and Medical Devices Engineering, de Gaulle' a Street 66, 41-800 Zabrze (Poland); Lesiak, Marta; Sieroń, Aleksander L. [Medical University of Silesia, Department of General and Molecular Biology and Genetics, Medyków Street 18, 40-752 Katowice (Poland); Simka, Wojciech [Silesian University of Technology, Department of Chemistry, Inorganic Technology and Fuels, B. Krzywoustego Street 6, 44-100 Gliwice (Poland); Mierzwiński, Maciej; Kusz, Damian [Medical University of Silesia, Department of Orthopedics and Traumatology, Ziołowa Street 45, 40-635 Katowice (Poland)

    2014-12-01

    In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3 h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers. - Highlights: • Isosorbide-based resin was used as a component of biodegradable scaffolds. • CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds. • Porous scaffolds displayed the formation of hydroxyapatite at their surfaces.

  19. Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic Acid Hydrogel for the Delivery of Isosorbide Mononitrate

    Directory of Open Access Journals (Sweden)

    Talib Hussain

    2013-01-01

    Full Text Available We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA and benzyl peroxide (BPO as cross-linker and initiator, respectively. Effect of acrylic acid (AA, polyvinylsulfonic acid (PVSA, and EGDMA on prepared hydrogels was investigated. All formulations showed higher swelling at high pHs and vice versa. Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling. Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate. FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network. All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents. Drug release data were fitted to various kinetics models. Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA hydrogels was non-Fickian and that the mechanism was diffusion-controlled.

  20. Formulation and In Vitro Characterization of Xanthan Gum-Based Sustained Release Matrix Tables of Isosorbide-5- Mononitrate

    Science.gov (United States)

    Kar, Rajat; Mohapatra, Snehamayee; Bhanja, Satyabrata; Das, Debjyoti; Barik, Bhaktibhusan

    2010-01-01

    In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r2 =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus. PMID:24363701

  1. N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules

    Science.gov (United States)

    Chen, Rui; Chen, Suming; Xiong, Caiqiao; Ding, Xunlei; Wu, Chih-Che; Chang, Huan-Cheng; Xiong, Shaoxiang; Nie, Zongxiu

    2012-09-01

    An organic salt, N-(1-naphthyl) ethylenediamine dinitrate (NEDN), with rationally designed properties of a strong UV absorbing chromophore, hydrogen binding and nitrate anion donors, has been employed as a matrix to analyze small molecules ( m/z interfering with MS analysis. For low-molecular-weight saccharides, the lowest detection limit achieved ranges from 500 amol to 5 pmol, depending on the molecular weight and the structure of the analytes. Additionally, the mass spectra in the lower mass range ( m/z analysis of small molecules with nitrate anion attachment.

  2. N-acetylcysteine modifies the acute effects of isosorbide-5-mononitrate in angina pectoris patients evaluated by exercise testing

    DEFF Research Database (Denmark)

    Svendsen, Jesper Hastrup; Klarlund, K; Aldershvile, J

    1989-01-01

    , given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG). Ten patients with angina pectoris and angiographically proven...... significant coronary artery disease were included. All patients received a baseline therapy with beta blockers. None of the patients had developed nitrate tolerance at inclusion. NAC/5-ISMN treatment significantly prolonged the total exercise time as compared with placebo/5-ISMN (7.7 +/- 2.1 min vs. 6.8 +/- 1...

  3. COMPARISON OF MISOPROSTOL AND MISOPROSTOL WITH ISOSORBIDE MONONITRATE IN SECOND TRIMESTER TERMINATION OF PREGNANCY

    Directory of Open Access Journals (Sweden)

    Shanthi Sivakumar

    2016-08-01

    Full Text Available BACKGROUND To compare the efficacy and side effect profile of vaginal misoprostol versus misoprostol and isosorbide mononitrate in enhancing cervical ripening in second trimester pregnancy termination. METHODS It is a random clinical trial done in 100 patients for mid trimester termination of pregnancy (between 12 and 24 weeks of gestational age. They were divided into two groups: Group A Combination of 400 mcg of misoprostol and 40 mg of ISMN placed intravaginally. Repeat doses included combination of 400 mcg of misoprostol and 20 mg of ISMN every 4 hours for maximum 4 doses. Group B 400 mcg of misoprostol placed intravaginally every 4 hours for maximum 4 doses for termination. In both the above-mentioned groups, T. mifepristone 600 mg was given orally 36-48 hrs. prior to termination. RESULTS The mean induction abortion interval was significantly less (7 hrs. 36 mins in Group A compared with group B (9 hrs. 55 min. There was no statistical significant difference in the amount of mean dose used in both groups. The complete abortion rate within 48 hrs. in Group A was 94%, which shows no statistical significance when compared with Group B complete abortion rates (80%. However, it is interpreted that on adding ISMN, the number of complete abortion rates are higher. There was no failure of abortion in both the groups. The side effects such as pain abdomen and fever were less in Group A (38% when compared to Group B (78%. CONCLUSION Vaginally administered ISMN seems to be safe and effective method in second trimester pregnancy termination. There is a reduction in hospital stay, manpower, economy spent on patient, and a sense of wellbeing from the patient also.

  4. Synthesis and Crystal Structure of [Cis-1,10- phenanthroline-palladium(Ⅱ)(THF)2]-dinitrate (THF = Tetrahydrofuran)

    Institute of Scientific and Technical Information of China (English)

    HUANG Hui; YU Shu-Yan

    2003-01-01

    A mononuclear complex, cis-1,10-phenanthroline-palladium(Ⅱ)(THF)2]dinitrate (THF = tetrahydrofuran) [Pd(C10H8N2)(C4H8O)2](NO3)2 1, has been prepared and structurally characterized by single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 7.881(1), b = 27.371(3), c = 10.178(1) A, β = 103.313(3)°, V = 2136.5(4) A3, Mr = 554.83, Dc = 1.725 g/cm3, Z = 4, F(000) = 1128 and μ(MoKα) = 0.926 mm-1. The structure was refined to R = 0.0678 and Wr = 0.1651 for 1687 observed reflections with I > 2σ(I). It is revealed that the central Pd(Ⅱ) ion in the title complex is bonded to two THF and two phenanthroline molecules in a cis-configuration to form the coordination geometry, deviating slightly from the square plane.

  5. Comparative study between vaginal isosorbide mononitrate and misoprostol for induction of cervical ripening prior to surgical evacuation of first trimester embryonic demise

    Directory of Open Access Journals (Sweden)

    Amrit Pal Kaur Dhillon

    2015-04-01

    Methods: This is a prospective, randomized, double blind controlled trial conducted at tertiary level teaching hospital. 50 women with first trimester embryonic demise with closed cervix requiring suction evacuation were divided randomly into two groups of 25 women each. In group A, tab. isosorbide mononitrate 80 mg and in group B, tab. misoprostol 400 and micro;g was applied vaginally. Both the drugs were repeated every three hourly up to a maximum of four doses or until reaching cervical dilation of 8 mm. Cervical dilatation was assessed at baseline and every three hours after each dose. A set of questionnaire was used for the appearance of side effects. Once 8 mm cervical dilatation achieved, suction evacuation was done. Total volume of blood lost at suction evacuation was measured. Results: Frequency of doses, induction to ripening interval and intra operative blood loss was significantly higher with isosorbide mononitrate as compared to misoprostol. Headache and palpitation were main side effects of isosorbide mononitrate. The percentages of successful and failed inductions were comparable in both the groups. Conclusions: Misoprostol is better cervical dilator prior to suction evacuation in first trimester embryonic demise with minimal side effects which are acceptable to the patient. [Int J Reprod Contracept Obstet Gynecol 2015; 4(2.000: 398-401

  6. Pharmacokinetic profile of a new controlled-release isosorbide-5-mononitrate 60 mg scored tablet (Monoket Multitab).

    Science.gov (United States)

    Stockis, Armel; De Bruyn, Steven; Deroubaix, Xavier; Jeanbaptiste, Bernard; Lebacq, Edouard; Nollevaux, Fabrice; Poli, Gianluigi; Acerbi, Daniela

    2002-01-01

    The influences of food, tablet splitting, and fractional dosing on the pharmacokinetics of a new controlled-release double-scored tablet containing 60 mg isosorbide-5-mononitrate (Monoket Multitab) were investigated in healthy male volunteers. Food interaction was evaluated after single dose administration under fasted conditions and after a standard high-fat breakfast. The effect of tablet splitting was assessed at steady-state, after 5 days of once daily dosing with the tablet taken intact or trisected. The influence of fractional dosing was assessed after 1 and 6 days of daily regimen of 40 mg in the morning (2/3 of a tablet) and 20 mg in the evening (1/3 of a tablet). The pharmacokinetics of isosorbide-5-mononitrate after taking the tablet intact or in three fragments were very similar with a mere 10% increase of maximum plasma concentration (C(max)) for the latter, while the time to peak (T(max)) decreased from 5 to 4 h and areas under the concentration vs. time curves (AUCs) were virtually unchanged. Morning trough concentration reached 53 and 46 ng/ml, respectively. Administration of the intact tablet after a high-fat breakfast increased C(max) by 18% and AUC by 21%, and slightly delayed T(max) from 5 to 6h. During fractional dosing, morning and evening C(max) reached 364 and 315 ng/ml on the first day, and 373 and 300 ng/ml on the 6th day, respectively. The ratio of AUC(0-24 h) on the last day to AUC(infinity) on the first day, was 82.1% (confidence limits 71.7-94.1%) possibly resulting from peripheral volume expansion. The release characteristics of Monoket Multitab are thus moderately influenced by concomitant intake of food and to a very minor extent by tablet breaking. Fractional dosing allows to achieve lower peak and higher morning trough levels, while total exposure is comparable to that during once daily dosing (AUC(0-24 h, s.s.) of 5.55+/-1.78 and 5.71+/-1.08 microg h/ml).

  7. Crystal and molecular structure of 2,2'-(quinoxaline-2,3-diyl)dipyridinium dinitrate (H2 L)(NO3)2

    Science.gov (United States)

    Egorova, O. A.; Polyakova, I. N.; Sergienko, V. S.; Davydov, V. V.

    2016-07-01

    The crystal structure of 2,2'-(quinoxaline-2,3-diyl)dipyridinium dinitrate (H2 L)(NO3)2 is studied by X-ray diffraction ( T = 150 K, R1 = 0.0467). The H2 L 2+ cation is located on the twofold rotation axis and connected with two NO3 - anions by strong N-H···O hydrogen bonds. Planar quinoxaline fragments of cations form stacks with the interplanar spacing of 3.308 Å. The structure of the diprotonated H2 L 2+ cation is compared with those of the monoprotonated H2 L 2+ cation and neutral L molecule.

  8. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of F-18-fluorocholine PET-CT

    NARCIS (Netherlands)

    Kluijfhout, Wouter P.; Vorselaars, WM; Vriens, Menno R.; Borel Rinkes, IHM; Valk, GD; de Keizer, B

    Objective: Assessment of the diagnostic value of ultrasound (US), single photon-emission computed tomography-computed tomography (SPECT-CT) and F-18-fluorocholine (FCH) PET-CT for preoperative localization of hyper-functioning parathyroid(s) in order to create a more efficient diagnostic pathway and

  9. Muscular fixing of the H.M.D.P. {sup 99m}Tc induced by a statin, rosuvastatin or crestor: clinical case; Fixation musculaire du HMDP Tc99m induite par une statine, la rosuvastatine ou Crestor: cas clinique

    Energy Technology Data Exchange (ETDEWEB)

    Bourahla, K.; Hassler, S.; Schneegans, O.; Gyen, L.N. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

    2010-07-01

    Myositis induced by statins in treatment for hypercholesterolemia is a special clinical entity that may be encountered during an exploration by bone scintigraphy. We present the case of a muscle fixing observed in bone scan in a patient treated with rosuvastatin (Crestor). Muscular extra bone fixing of hydroxy-methane diphosphonate (H.M.D.P.) {sup 99m}T in patients referred for staging of prostate carcinoma, patients sometimes also treated for high cholesterol may be iatrogenic due to taking statins. A simple history may then allow its identification, although it remains asymptomatic. (N.C.)

  10. Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures. Progress report, May 1, 1981-April 30, 1982

    Energy Technology Data Exchange (ETDEWEB)

    Heineman, W.R.; Deutsch, E.A.

    1981-12-01

    The objectives of this year's research were to develop a method for rapidly determining TcO/sub 4//sup -/ in /sup 99/Mo//sup 99m/Tc generator eluates, to improve the ability to chromatographically determine individual Tc-HEDP complexes in radiopharmaceuticals, and to investigate the effects of TcO/sub 4//sup -/ concentration and electrochemical reduction on the types and relative amounts of Tc-HEDP complexes present in a radiopharmaceutical formulation. A rapid and sensitive high performance liquid chromatographic (HPLC) method for the quantitative determination of pertechnetate (TcO/sub 4//sup -/) was developed. This HPLC-based analysis may be of considerable utility in assessing the history and function of /sup 99/MO/sup 99m/Tc generators as well as in the routine analysis of reduced technetium radiopharmaceuticals for the presence of undesired TcO/sub 4//sup -/. Encouraging results were obtained on a dimethyl amine column using aqueous (NH/sub 4/)/sub 2/SO/sub 4/ as the mobile phase. The preparation of Tc(NaBH/sub 4/) HEDP radiopharmaceutical analogues using varying concentrations of total TcO/sub 4//sup -/ shows a dramatic effect in the number and distribution of Tc-HEDP complexes over a TcO/sub 4//sup -/ concentration range of 10/sup -2/ to 10/sup -8/M. These results suggest that total TcO/sub 4//sup -/ concentration is an important parameter to be considered in the preparation of a specific Tc-HEDP complex to improve skeletal imaging. The preparation of Tc(electrode) HEDP radiopharmaceutical analogues by using electrochemical reduction was explored. The resulting solutions contain Tc-HEDP complexes that are tentatively identified as being the same complexes formed by NaBH/sub 4/ reduction, although the relative concentrations of these complexes are quite different with the two modes of reduction. Thus, electrochemical reduction shows promise as a viable route to the preparation of specific Tc-HEDP complexes for improved skeletal imaging.

  11. Observer variability in the evaluation of dual-isotope Tl-201/Tc-99m sestamibi rest/stress myocardial perfusion SPECT in men and women with known or suspected stable angina pectoris

    DEFF Research Database (Denmark)

    Johansen, Allan; Høilund-Carlsen, Poul Flemming; Christensen, Henrik Wulff

    2004-01-01

    BACKGROUND: Observer variability of dual-isotope myocardial perfusion imaging (MPI) with single photon emission computed tomography has rarely been investigated. The aim of our study was to evaluate the interpretive reproducibility with this technique. METHODS AND RESULTS: We report on 507 patients...... with known or suspected stable angina who were studied before coronary angiography. A 1-day thallium 201/technetium 99m sestamibi rest/stress MPI protocol was used. MPI was interpreted by 2 independent observers without knowledge of clinical data, using a 20-segment scoring model. By consensus, the overall...... rate of abnormal MPI was 49% (59% in men and 34% in women). The interobserver agreement for the whole group (kappa = 0.85) and for men and women separately (kappa = 0.86 and 0.82, respectively) was excellent with regard to the overall diagnosis (normal, reversible, or fixed defects) as well as left...

  12. Quantification of Tc-99m-ethyl cysteinate dimer brain single photon emission computed tomography images using statistical probabilistic brain atlas in depressive end-stage renal disease patients Correlation with disease severity and symptom factors

    Institute of Scientific and Technical Information of China (English)

    Heeyoung Kim; In Joo Kim; Seong-Jang Kim; Sang Heon Song; Kyoungjune Pak; Keunyoung Kim

    2012-01-01

    This study adapted a statistical probabilistic anatomical map of the brain for single photon emission computed tomography images of depressive end-stage renal disease patients. This research aimed to investigate the relationship between symptom clusters, disease severity, and cerebral blood flow. Twenty-seven patients (16 males, 11 females) with stages 4 and 5 end-stage renal disease were enrolled, along with 25 healthy controls. All patients underwent depressive mood assessment and brain single photon emission computed tomography. The statistical probabilistic anatomical map images were used to calculate the brain single photon emission computed tomography counts. Asymmetric index was acquired and Pearson correlation analysis was performed to analyze the correlation between symptom factors, severity, and regional cerebral blood flow. The depression factors of the Hamilton Depression Rating Scale showed a negative correlation with cerebral blood flow in the left amygdale. The insomnia factor showed negative correlations with cerebral blood flow in the left amygdala, right superior frontal gyrus, right middle frontal gyrus, and left middle frontal gyrus. The anxiety factor showed a positive correlation with cerebral glucose metabolism in the cerebellar vermis and a negative correlation with cerebral glucose metabolism in the left globus pallidus, right inferior frontal gyrus, both temporal poles, and left parahippocampus. The overall depression severity (total scores of Hamilton Depression Rating Scale) was negatively correlated with the statistical probabilistic anatomical map results in the left amygdala and right inferior frontal gyrus. In conclusion, our results demonstrated that the disease severity and extent of cerebral blood flow quantified by a probabilistic brain atlas was related to various brain areas in terms of the overall severity and symptom factors in end-stage renal disease patients.

  13. Clinical use of regional Tc-99m-HMPAO uptake in dementia of the Alzheimer type (DAT). Klinische Wertigkeit des regionalen [sup 99m]Tc-HMPAO Uptake bei der Demenz vom Alzheimer-Typ (DAT)

    Energy Technology Data Exchange (ETDEWEB)

    Gebhardt, U. (Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany)); Schmauss, F. (Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany)); Wagner-Manslau, C. (Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany)); Buttermann, G. (Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany)); Zimmer, R. (Psychiatrische Klinik, TU Muenchen (Germany))

    1993-12-01

    In 46 patients with dementia of the Alzheimer type (DAT) regional cerebral blood flow (rCBF) was compared with cognitive performance (MMSE, CAMCOG). The cortico-cerebellar ratio (CCR), determined by [sup 99m]Tc-HMPAO-SPECT was used as a rCBF-equivalent. In the mild demented group we found a bilateral CCR-reduction parietal posterior, in moderate DAT bilateral temporoparietal and leftsided frontolateral defects were seen. Severe DAT showed an additional perfusion decrease mid frontal. With increasing severity of DAT an asymmetric perfusion occurred in 17/46 patients with accentuated CCR-reduction on the left side (temporal>parietal). High correlations between CCR and MMSE (r[>=]0.70) existed frontolateral, temporal and parietal in the left hemisphere. Significant associations between CCR and CAMCOG were obtained for language in the left temporal posterior region (r=0.64), for memory task left temporal anterior (r=0.59) and for praxis left parietal posterior (r=0.55). In detecting rCBF abnormalities the sensitivity for all 46 DAT patients was 91% and 70% in the mild cases. (orig.)

  14. Observer variability in the evaluation of dual-isotope Tl-201/Tc-99m sestamibi rest/stress myocardial perfusion SPECT in men and women with known or suspected stable angina pectoris

    DEFF Research Database (Denmark)

    Johansen, Allan; Høilund-Carlsen, Poul Flemming; Christensen, Henrik Wulff

    2004-01-01

    with known or suspected stable angina who were studied before coronary angiography. A 1-day thallium 201/technetium 99m sestamibi rest/stress MPI protocol was used. MPI was interpreted by 2 independent observers without knowledge of clinical data, using a 20-segment scoring model. By consensus, the overall...

  15. Development of a formulation lyophilized for the obtention of a antimicrobial peptide Ubiquicidine labelled with {sup 99m} Tc; Desarrollo de una formulacion liofilizada para la obtencion del peptido antimicrobiano Ubiquicidina marcado con Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Palomares R, P.; Hernandez B, C.A.; Contreras N, G.; Garcia P, M.L.; Pantoja H, I.E. [UAEM, Toluca (Mexico); Ferro F, G. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)]. E-mail: patodish@hotmail.com

    2004-07-01

    The {sup 99m} Tc-UBI 29-41 are a labelled fragment of the antimicrobial human peptide Ubiquicidine proposed as a new radiopharmaceutical able to differentiate an infectious process of an inflammatory one through the gamma graphic image. It has been demonstrated that the {sup 99m} Tc-UBI 29-41 unite to bacteria in vitro and that accumulates in infection sites in human with minimum captivation in inflammation sites. In this work the development of a pharmaceutical lyophilized formulation is presented for the instantaneous marked one of the UBI 29-41 with {sup 99m} Tc. The selection of the components of the formulation settled down by means of the employment of an experimental design of 3 factors with mixed levels, evaluating the effect of the diluent type, concentration of tinny chloride and the reaction volume. The obtained formulations showed to be stable until for 6 months, being obtained complexes of the radiolabelled peptide with radiochemical purity > 95 % in sterile form and apirogen. The developed pharmaceutical form, will facilitate the routinary use of this new radiopharmaceutical in the diverse hospital departments of nuclear medicine. (Author)

  16. 单硝酸异山梨醇酯致老年低血压的临床分析%Senile hypotension induced by isosorbide-5-mononitrate

    Institute of Scientific and Technical Information of China (English)

    罗继征; 王荃; 郝从均

    2014-01-01

    目的:对单硝酸异山梨醇酯缓释片导致老年低血压进行分析,以便更好的进行防治。方法对8例因鼻饲单硝酸异山梨醇酯缓释片后,导致低血压状态的老年患者的临床特点、救治情况进行分析,并与同期相同方式用药未出现低血压的9例患者进行对比分析。结果8例患者均为60 mg/日,用药后出现低血压,6例患者使用多巴胺升压、扩容等综合治疗后好转,严重1例并发急性心肌梗死及急性肾功能衰竭,经机械通气等抢救好转。与非低血压组比较,病情不稳定、单硝酸异山梨醇酯用药剂量大、时间长、并用降压药物、近期鼻饲给药比例较高,差异有统计学意义(P<0.05)。结论高龄老年患者尤其是病情不稳定、并用降压药物、近期鼻饲使用高剂量单硝酸异山梨醇酯缓释片容易出现低血压,甚至可导致严重并发症。%Objective To analyze the occurrence of senile hypotension induced by isosorbide-5-mononitrate in order to prevent and cure well hypotension. Methods The clinical characteristics and remedy were analyzed in 8 elderly patients with hypotension after nasal feeding of isosorbide-5-mononitrate, who were compared with other 9 patients without hypotension after nasal feeding of isosorbide-5-mononitrate at the same time. Results The patients (n=8) suffered from hypotension after nasal feeding of isosorbide-5-mononitrate (60 mg/d), among them, 6 were relieved after blood pressure-elevating and volume-expansion treatment with dopamine, 1 had acute myocardial infarction and acute renal failure and relieved after rescue of mechanical ventilation. The clinical characteristics included unstable condition, higher dose and longer time of taking isosorbide-5-mononitrate, administration of anti-hypertension drugs, and higher proportion of recent nasal feeding in hypotension group, and the difference was statistical significant between hypotension group and non

  17. Synthesis and X-Ray Structure of [N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl-1-hydroxy-2-aminoethane](3,5-dimethylpyrazole copper(II dinitrate

    Directory of Open Access Journals (Sweden)

    Driss Eddike

    2003-11-01

    Full Text Available The tridentate ligand N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl-1-hydroxy-2-aminoethane (L has been prepared in one step by condensation of two equivalents of 1-hydroxymethyl-3,5-dimethylpyrazole with one equivalent of 2-aminoethanol. This reaction is carried out under microwave irradiation (60 W in the absence of solvent for 20 min [1]. Using this ligand L a new Cu(II dinitrate complex has been prepared. The singlecrystal X-ray structure of the title compound, [N,N-bis(3,5-dimethylpyrazol-1-ylmethyl-1-hydroxy-2-aminoethane] (3,5-dimethylpyrazolecopper(II dinitrate, revels that the copper (II ion is coordinated to two pyrazole nitrogens, one tertiary amine nitrogen of the ligand L and 3,5-dimethylpyrazole, and in the apical position by an alcohol O atom.

  18. A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum.

    Science.gov (United States)

    Li, Ning; Li, Chun-lan; Lu, Ning-wei; Dong, Yu-ming

    2014-09-15

    A novel micellar per aqueous liquid chromatographic method was investigated to simultaneously determine diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum. Separation and determination of the analytes were performed on a Pinnacle II Cyano column as the stationary phase using the mobile phase consisted of aqueous solution (4.15×10(-2) mol/L sodium dodecyl sulfate and 0.02 mol/L sodium dihydrogen phosphate) with 10% (v/v) of 1-propanol at pH 7.0. This method was validated by linearity, lower limit of quantification, extraction recovery, stability, precision, and accuracy. The main analytical parameters were linearity (r>0.9950), intra- and inter-day precisions (intra-day RSD 2.2-3.5%, and inter-day RSD 3.7-9.5%), lower limit of quantification (20 ng mL(-1) for isosorbide mononitrate, metoprolol tartrate and diltiazem hydrochloride). The extraction recovery was 63.3% (0.1 μg/mL), 65.6% (1.0 μg/mL), and 69.5% (25 μg/mL) for isosorbide mononitrate; 65.1% (0.1 μg/mL), 69.5% (1.0 μg mL) and 73.5% (2.5 μg/mL) for metoprolol tartrate; 67.1% (0.1 μg/mL), 68.8% (1.0 μg/mL) and 73.8 % (2.5 μg/mL) for diltiazem hydrochloride. The relative error of stability was <6.4% at the room temperature for 24h, <3.8% at 4 °C for 1 week, <4.6% at -20 °C for 1 month, and <6.7% for freeze/thaw cycles (n=3). The results indicated that the proposed method was rapid, sensitive, and accurate for determination of the three antianginal drugs in human serum. The possible separation mechanism of the method was also discussed, and a model of separation mechanism for the analytes was established.

  19. Dehydration of sorbitol to isosorbide on solid acid catalyst%催化山梨醇脱水制备异山梨醇的固体酸催化剂

    Institute of Scientific and Technical Information of China (English)

    孙鹏; 耿红冉; 李正文; 张小伟; 余定华

    2011-01-01

    为提高目标产物异山梨醇的产率,考察多种固体酸催化剂催化山梨醇脱水的反应性能.结果表明:催化剂酸性与其催化性能之间有密切联系,酸性较强的H3PO4/Nb2O5催化剂显示出比其他催化剂更优异的催化性能.对磷酸负载量进行优化后,在n(P)/n(Nb)为0.8的H3 PO4/Nb2O5催化剂上得到了100%的山梨醇转化率和63%的异山梨醇选择性.%Dehydration of sorbitol to isosorbide on various solid acids was investigated to improve isosor-bide yield. The results showed that the catalytic performances of solid acids were closely related to their acidities. H3PO4/Nb2O5 catalyst with stronger acidity showed better catalytic performance than other solid acids. The 100% sorbitol conversion and 63% isosorbide selectivity was obtained on H3PO4/Nb2O5 catalyst with n(P)/n(Nb) =0.8.

  20. Synthesis and X-Ray Structure of [N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane](3,5-dimethylpyrazole) copper(II) dinitrate

    OpenAIRE

    Driss Eddike; Sghir El Kadiri; Abdelkrim Ramdani; Rachid Touzani; Fouad Malek; Mohamed El Kodadi

    2003-01-01

    The tridentate ligand N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (L) has been prepared in one step by condensation of two equivalents of 1-hydroxymethyl-3,5-dimethylpyrazole with one equivalent of 2-aminoethanol. This reaction is carried out under microwave irradiation (60 W) in the absence of solvent for 20 min [1]. Using this ligand L a new Cu(II) dinitrate complex has been prepared. The singlecrystal X-ray structure of the title compound, [N,N-bis(3,5-dimethylpyrazol-1...

  1. Isosorbide-5-mononitrate (5-ISMN) sustained-release pellets prepared by double layer coating for reducing 5-ISMN migration and sublimation.

    Science.gov (United States)

    Li, Guofei; Han, Dandan; Guan, Tingting; Zhao, Xingna; He, Haibing; Tang, Xing

    2010-11-15

    The major aim of this study was to prepare isosorbide-5-mononitrate (5-ISMN) sustained-release pellets and evaluate their stability. The pellets were prepared by extrusion/spheronization, and then the core pellets were coated with ethylcellulose (EC 10cp) and Eudragit(®)NE30D. Here, EC was used as the subcoating agent while Eudragit(®)NE30D acted as the outer-coating agent. 5-ISMN sustained-release pellets as a novel drug delivery system contained the immediate-release portion in the outer-coating layer. Unexpectedly, 5-ISMN was found to migrate from the interior of the pellets to the surface forming needle crystals and exhibited the phenomenon of sublimation, which resulted in a tremendous increase in the release rate. Our research showed that the migration and sublimation of the active ingredient was related to the temperature and humidity. Polyvinylpyrrolidone (PVP K30) can affect the precipitation of 5-ISMN by forming a charge transfer complex between the drug and PVP, while hydroxypropyl methyl cellulose (HPMC E5) had no effect, and confirmed the correctness of this view through photographs and IR spectra. In the investigation of the stability, the results showed that there was no sublimation and migration while the pellets stored at 25°C/60%RH (ambient conditions) and 40°C/75% RH (stress conditions) during a 6-month period.

  2. Efficacy of β-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Shi-Hua Ding; Jun Liu; Jian-Ping Wang

    2009-01-01

    AIM: To systematically assess the efficacy and safety of β-adrenergic blocker plus 5-isosorbide mononitrate (BB + ISMN) and endoscopic band ligation (EBL) on prophylaxis of esophageal variceal rebleeding. METHODS: Randomized controlled trials (RCTs) comparing the efficacy and safety of BB + ISMN and EBL on prophylaxis of esophageal variceal rebleeding were gathered from Medline, Embase, Cochrane Controlled Trial Registry and China Biological Medicine database between January 1980 and August 2007. Data from five trials were extracted and pooled. The analyses of the available data using the Revman 4.2 software were based on the intention-to-treat principle. RESULTS: Four RCTs met the inclusion criteria. In comparison with BB + ISMN with EBL in prophylaxis of esophageal variceal rebleeding, there was no significant difference in the rate of rebleeding [relative risk (RR), 0.79; 95% CI: 0.62-1.00; P = 0.05], bleedingrelated mortality (RR, 0.76; 95% CI: 0.31-1.42; P = 0.40), overall mortality (RR, 0.81; 95% CI: 0.61-1.08; P = 0.15) and complications (RR, 1.26; 95% CI: 0.93-1.70; P = 0.13). CONCLUSION:In the prevention of esophageal variceal rebleeding, BB + ISMN are as effective as EBL. There are few complications with the two treatment modalities. Both BB + ISMN and EBL would be considered as the first-line therapy in the prevention of esophageal variceal rebleeding.

  3. Heart failure

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920647 Comparative effects of commonvasodilators on experimental cardiac fai-lure. LI Zhijian (李志坚), et al. Dept Cardiol,2nd Hosp, Tianjin Med Coll. Tianjin Med J1992; 20(8): 456-458. A 9×9 latin square design was employed forcomparing the effects of (1) placebo, (2) nitr-oprusside, (3) phentolamine, (4) isosorbide dini-trate. (5) captopril, (6) captopril-isosorbide

  4. Bicyclooctane derivatives as plasticisers

    NARCIS (Netherlands)

    Jansen, J.C.; Luitjes, H.

    1999-01-01

    The use of isosorbide esters, isosorbide polyesters, isosorbide ethers, isosorbide carbonates, isosorbide thioethers, isosorbide thioesters, isosorbide amides, isosorbide (thio)urethanes, isosorbide urea, isosorbide phosphates and isosorbide phosphonates as a plasticizer is described. Instead of iso

  5. Synthsis of Methane Boronic Acid Adduct of 99mTc-Cyclohexanedione Dioxime Coordination Compound and Study of Oxidation State of 99Tc Coordination Surronding of 99Tc%99 mTc-环己二酮肟配合物甲硼酸加合物的合成与99Tc的价态及其配位环境研究

    Institute of Scientific and Technical Information of China (English)

    宋纯义; 董纪昌; 杨一峰; 蒋长英; 林海; 汪芳

    2001-01-01

    目的制备一种99mTc标记的心肌显像剂--99mTc-环己二酮肟配合物甲硼酸加合物,并对该显像剂99Tc的价态、99Tc的配位环境、放射化学纯度以及γ-CD在药盒中的作用进行了研究.方法使用X射线光电子能谱(XPS)、纸层析法和循环伏安法(CV).结果99Tc-Teboroxime(由环己二酮肟、甲硼酸与SnCl2还原了的99Tc形成的配合物)是99Tc(Ⅲ),且存在:N→99Tc和CL→99Tc配位键.该配合物放置6 h,XPS信号无明显变化.放置8 h,99Tc3d5/2的EB值向高位能偏移,生成99Tc(Ⅳ).其放化纯度较高且稳定[平均放化纯度(95.19±3.13)%].此外,用循环伏安法显示,γ-CD在药盒中有稳定的作用.结论制备的心肌显像剂--99Tc-环己二酮肟配合物甲硼酸加合物是一种配位化合物,其稳定性良好,可供临床应用.

  6. Diagnosis of leg osseous infection in diabetics: place of scintigraphy of the polynuclear hydrocarbons labelled by HMPAO-{sup 99m}Tc (HMPAO-LS); Diagnostic de l`infection osseuse du pied chez le diabetique: place de la scintigraphie aux polynucleaires marques a l`HMPAO-Tc 99m (HMPAO-LS)

    Energy Technology Data Exchange (ETDEWEB)

    Devillers, A.; Moisan, A.; Hennion, F.; Poirier, J.Y.; Bourguet, P. [CRLCC Eugene Marquis, Medecine Nucleaire, CHRU Endocrinologie, Rennes (France)

    1997-12-31

    In case of leg infection in diabetics it is difficult to differentiate between a chronic osteopathy, an infection of the soft tissues and an osteomyelitis (OM). We considered of interest to evaluate by a HMPAO-LS prospective study the diagnosis of osteitis in diabetic legs. Twenty seven diabetic (DID type 1 = 11, DNID type 2 = 16) patients (19 M and 8 F, average age 64 years), clinically suspected with a leg osteo-articular infection (malum perforans or cellulitis, uni- or bi-lateral, unique or multiple lesions) were included in the study. For all of them a standard radiographic examination centered on the legs, a (3 phases) osseous scintigraphy and a HMPAO-LS were achieved over 3 days. The HMPAO-LS was considered as in favour of a OM when there was an abnormal accumulation of granulocytes concordant with a hyper-fixation by osseous scintigraphy. In case of 37 retained lesions 20 OM were proved: - 8 sites, on radiological arguments and histological and/or microbiological criteria after osseous biopsy; - 8, by the radiological examination only; - 4, on biopsy arguments, only. Seventeen lesions were not OM, of which 7 were cellulitis. The sensitivity of the HMPAO-LS was 90% with a specificity of 94%. 8/20 OM had initial normal radiographs confirming the precocity of OM diagnosis by HMPAO-LS. Twelve HMPAO-LS were effected in OM evolutive surveillance. All of them became negative on the control initial site of the healing of OM. In conclusion, the HMPAO-LS appears to be an alternative to choose in the diagnosis and in the evolution surveillance of leg OM in diabetics, particularly when the healing of the perforans softs is incomplete and the question of the osteitis healing or sequel of an anti-biotherapy is posed

  7. Cerebral scintigraphy by {sup 99m}Tc-HMPAO in sleep apnea syndromes (SAS) during the wakeful state; Scintigraphie cerebrale au Tc99m-HMPAO dans les syndromes d`apnees du sommeil (SAS) pendant l`etat de veille

    Energy Technology Data Exchange (ETDEWEB)

    Tainturier, C.; Benamor, M.; Hausser-Hauw, C.; Rakotonanahary, D.; Fleury, B. [CMC FOCH 92150 SURESNES (France)

    1997-12-31

    The SAS is associated to cerebral hemodynamic modifications and to a high frequency of cerebro-vascular accidents. The aim of this study was to verify, during wakeful state, the cerebral hemodynamic in 14 patients afflicted with SAS of various intensity (Apnea Index = 5-120/h). 555 MBq of {sup 99m}Tc-HMPAO were injected in patients maintained awake. The images were obtained 20 minutes after injection by mean of a double-head chamber equipped with fan-beam collimators. They were interpreted visually by two independent readers. Anomalies of cerebral fixation were observed in 12/14 patients. They were small sores of diffuse hypo-fixations, with a `riddly` aspect (4 cases), sores of bi-temporal hypo-fixation with a right- or left- hemispheric predominance (6 cases), or right fronto-temporal hypo-fixations (2 cases). The cerebral fixation anomalies were reported in the SASs. Ficker et al (1997) have shown in-sleep frontal hypo-perfusions in 5/14 apneic patients, reversible under continuous positive airing pressure (CPAP). In conclusion, anomalies of cerebral fixation exist in SAS-carrying patients, even in the wakeful state. Questions about hypoperfusion, pre-lacunar syndrome, atrophy still remain. A check of this study is planned after the CPAP treatment to determine the hemodynamic or anatomic origin and the anomaly reversibility

  8. Contribution of perfusion scintigraphy with {sup 99m}Tc macro aggregates of albumin in the intrapulmonary shunt: about one case; Apport de la scintigraphie de perfusion au Tc-99m macro-agregats d'albumine dans les shunts intrapulmonaires: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Bourdon, A.; Sibille, L.; Mariano-Goulart, D.; Rossi, M. [CHU Lapeyronie, Service de medecine nucleaire, 34 - Montpellier (France); Renoux, M.C. [CHU Arnaud-de-Villeneuve, service de pediatrie, 34 - Montpellier (France)

    2010-07-01

    Purpose: report the contribution of scintigraphy in the research of a right-left intrapulmonary shunt after injection of technetium labelled albumin aggregates ({sup 99m}Tc M.A.A.). Results: Scintigraphy highlights a right inferior lobe perfusion default as well as an important extra pulmonary uptake, especially at the brain, thyroid, salivary glands, kidneys and digestive tract level. A chromatography is realised in order to get rid of any problem of labelling. The intrapulmonary shunt is evaluated to 20%. Angio scanner allowed to confirm the presence of an right inferior lobe arteriovenous voluminous malformation, corresponding to the perfusion default visualized during scintigraphy. In the present case, scintigraphy helped to the diagnosis, but it allows above all the evaluation of therapy efficiency (embolization or surgery) during the patients follow-up.This examination of simple realisation is equally used in the follow-up of hepato-renal syndromes. (N.C.)

  9. [Effectiveness of nifedipine on exercise tolerance in patients with angina pectoris. Comparison with a nitroderivative and a beta-blocking agent].

    Science.gov (United States)

    De Ponti, C; Mauri, F; Fiorista, F; Ciliberto, G R; Carù, B; Rovelli, F

    1977-01-01

    The effect of nifedipine on effort angina was investigated by means of exercise tests with bycicle ergometer and compared, in the same patients, with the effects of a nitroderivative and a betablocking agent. Five patients with stable effort angina entered the study, after an hemodynamic and contrasto-graphic control. According to the protocol of a latin square 5 X 5, all the patients received in a random sequence the following treatments: placebo, 1 c. orally; isosorbide dinitrate, 5 mg sublingually; propranolol, 40 mg orally; nifedipine, 10 mg sublingually; nifedipine, 10 mg orally. No significant change of any of the considered parameters was observed after the placebo. Isosorbide dinitrate and nifedipine produced significant increases of the duration of work before appearance of pain and EKG positivity, and of total work performed before anginal pain. Only the duration of work before EKG positivity was improved by propranolol. The comparisons between treatments showed no significant difference of the effects of the administered doses of isosorbide dinitrate and nifedipine. The improvements observed after propranolol were significantly lower than that observed after isosorbide dinitrate and oral nifedipine. On the basis of the observed changes of cardiac rate, maximal arterial pressure, ejection time index and triple product, the authors evaluate the possible mechanism of action of nifedipine.

  10. Synthesis and Phase Behavior of Branched-Arm Liquid Crystalline-Containing Isosorbide with Chiral Core%以手性核为中心的枝臂液晶的合成与相行为

    Institute of Scientific and Technical Information of China (English)

    何晓智; 韩丽; 姚丹姝; 田梅

    2013-01-01

    In this paper, three branched-arm liquid crystalline:bi-10-(4(4-(4-ethoxyl)benzoxy)biphenyl) decylic acid isosorbide ester(MA1) , bi-4-[10-(4(4-(4-ethoxyl)biphenyl)biphenyl)oxycarbonyl capryloxy] benzoic isosorbide ester(MA2), bi-3,4,5-三-[l0-(4(4-(4-ethoxyl)benzoxy)biphenyl)oxycarbonyl capryloxy] benzoic isosorbide ester (MA3), were synthesized. The structures, optical and thermodynamic properties of the liquid crystalline were investigated by FT-IR spectroscopy, 1H-NMR, differential scanning calorimetry (DSC) and polarizing optical microscopy (POM). MA1 ~ MA3 all show the cholesteric phase. MA3 which has six-arms owns more liquid crystalline texture and wide scopes of liquid crystalline phase. MA1 and MA2 have the right-hand rotation, but MA3 owns the left-hand rotation, which is opposite to the rotation of the chiral core. These branched-arm molecules turn out good fluidity and clear characteristic texture.%设计与合成了3种以异山梨醇为手性核中心的枝臂液晶分子——双-10-(4-(4-(4-乙氧基)苯甲酰氧基)联苯)氧羰基癸酸异山梨醇酯(MA1)、双-4-[10-(4-(4-(4-乙氧基)苯甲酰氧基)联苯)氧羰基癸酰氧基]苯甲(酸)异山梨醇酯(MA2)、双-3,4,5-三-[10-(4-(4-(4-乙氧基)苯甲酰氧基)联苯)氧羰基癸酰氧基]苯甲酸异山梨醇酯(MA3).通过红外光谱、核磁共振、偏光显微镜、差示扫描量热和X射线衍射等手段研究了枝臂液晶分子的结构和性能.MA1~MA3均为胆甾相液晶,且具有6个臂的MA3织构较丰富且液晶相范围也较宽.手性分子MA1、MA2为右旋,而MA3为左旋,与手性核的旋光度方向相反,具有很好的流动性及清晰的特征织构.

  11. Preparation of Isosorbide Mononitrate Controlled Release Tablets and Evaluation of Their Bioavailability in Beagle Dogs%单硝酸异山梨酯控释片的制备及在Beagle犬体内生物利用度研究

    Institute of Scientific and Technical Information of China (English)

    李欣; 姜庆伟; 杜丽娜

    2011-01-01

    目的 制备单硝酸异山梨酯控释片,考察其在Beagle犬体内的药动学及相对生物利用度.方法 采用单室渗透泵技术制备控释片,采用两制剂、双周期交叉试验设计,气相色谱-电子捕获法对犬体内血药浓度进行分析;DAS 2.0软件计算药动学参数.结果 受试犬服用自制控释片和市售缓释片(参比制剂)后药时曲线相似,主要药动学参数分别为:t1/2(5.083±1.524)和(4.866±1.361)h,Cmax(0.617±0.213)和(0.753±0.228)μg/ml,Tmax(2.250±0.880)和(2.722±0.935)h,AUC0-t)(5.086±0.832)和(4.997±0.916)μg·h/ml,AUC(0-∞)(5.254±0.754)和(5.258±1.032)μg·h/ml,相对生物利用度为(101.0±17.7)%.结论 单硝酸异山梨酯控释片与市售缓释片主要药动学参数无显著性差异,两制剂具有生物等效性.%Objective To prepare isosorbide mononitrate controlled release tablets and study their pharmacokinetics and relative bioavailability in Beagle dogs. Methods Isosorbide mononitrate controlled release tablets were prepared by monolithic osmotic pump technique. These tablets and isosorbide mononitrate sustained release tablets (reference formulation) were given orally to Beagle dogs by a two-crossover design. Drug concentrations in plasma were determined by gas chromatography-electron capture detector and the pharmacokinetic parameters of isosorbide mononitrate were analyzed by DAS 2.0. Results The main pharmacokinetic parameters of the self-made controlled release tablets and reference formulation were as follows: t 1/2 was ( 5. 083 ± 1. 524 ) and (4.866 ± 1.361 )h, Cmaxwas(0.617 ±0.213)and(0.753 ±0.228)μg/ml, Tmaxwas(2.250 ±0.880) and (2.722 ±0.935) h;AUC(0-t) was (5. 086 ± 0. 832 ) and ( 4. 997 ± 0. 916 ) μg · h/ml, AUC(0-∞ ) was ( 5. 254 ± 0. 754 ) and ( 5. 258 ±1. 032 )μg ·h/ml. The relative bioavailability was ( 101.0 ± 17.7 ) %. Conclusion Compared with the sustained release tablets, isosorbide mononitrate controlled release tablets have a

  12. 复方丹参滴丸与单硝酸异山梨脂缓释片联用治疗不稳定性心绞痛56例效果观察%The Clinical Effect Observation on Compound Danshen Dropping Pill Combined With Single Nitrate Isosorbide Sustained-releaseTablets for the Treatment of 56 Cases of Unstable Angina

    Institute of Scientific and Technical Information of China (English)

    朱宏涛

    2015-01-01

    目的:观察复方丹参滴丸与单硝酸异山梨脂缓释片联用治疗不稳定性心绞痛的临床效果。方法选取2011年6月~2012年2月到本院治疗的120例不稳定性心绞痛的患者为研究对象,将120例患者随机分两组,一组56例为实验组;一组64例为对照组。实验组给予复方丹参滴丸与单硝酸异山梨脂缓释片联用,对照组单纯给予单硝酸异山梨脂缓释片治疗。治疗结束后,统计实验组及对照组患者的心电图好转情况。结果治疗结束后,实验组心电图改善率(64.3%)明显高于对照组43.8%,P<0.05,差异有统计学意义。结论复方丹参滴丸与单硝酸异山梨脂缓释片联用治疗不稳定性心绞痛的临床效果较单纯应用单硝酸异山梨脂缓释片好。%ObjectiveTo observe the clinical effect of compound danshen dropping pill combined with single nitrate isosorbide sustained-release tablets for the treatment of unstable angina.Methods From June 2011 to February 2012, 120 patients with unstable angina in our hospital were randomly divided into two groups, the experimental group (56 cases) and control group (64 cases). The compound danshen dropping pill combined with single nitrate isosorbide sustained-release tablets was given in experimental group, single nitrate isosorbide sustained-release tablets was given in control group. After the treatment, the electrocardiogram situations were analyzed between the two groups.Results After the treatment, in experimental group, the electrocardiogram improvement rate was (64.3%). It was significantly higher than the control group (43.8%), P<0.05, there was difference.Conclusions The clinical effect of compound danshen dropping pill combined with single nitrate isosorbide sustained-release tablets for the treatment of unstable angina was better than simple application of single nitrate isosorbide sustained-release tablets.

  13. IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN prior to induction of labour – clinical trial with analyses of efficacy, cost effectiveness and acceptability

    Directory of Open Access Journals (Sweden)

    Greer Ian

    2006-07-01

    Full Text Available Abstract Background There is increasing interest in carrying out pre-induction cervical ripening on an outpatient basis. However, there are concerns about the use of prostaglandins, the agents commonly used in hospital settings for this indication, because prostaglandins induce uterine contractions that may lead to fetal hypoxia. Indeed, in a recent study we demonstrated abnormalities in 9% of fetal heart rate tracings performed following prostaglandin induced cervical ripening at term. In contrast, we confirmed in the same study that isosorbide mononitrate (IMN (administered on an inpatient basis was both effective in inducing cervical ripening at term, and was associated with no associated fetal heart rate abnormalities. Methods/design The aim of this study is to determine whether IMN self administered by women on an outpatient basis improves the process of induction of labour. Specifically, we hypothesise that the use of outpatient IMN will result in a shorter inpatient stay before delivery, decreased costs to the health service and greater maternal satisfaction with ripening and induction of labour, compared with placebo treatment. In the study described here (the "IMOP" study, women scheduled for induction of labour at term, and who require pre-induction cervical ripening will be randomised to self-administer at home either IMN 40 mg, or a placebo, each vaginally, at 48 hours, 32 hours and 16 hours before scheduled hospital admission. After admission to hospital, treatment will revert to the usual induction of labour protocol. We will compare the primary outcomes of the elapsed time interval from hospital admission to vaginal delivery, the costs to the health service of induction of labour, and women's experience of induction of labour in the two groups. Discussion This trial will provide evidence on the efficacy of outpatient IMN for pre-induction cervical ripening at term. We will study a formulation of IMN which is cheap and widely

  14. Tetraaquabis(pyridine-κNnickel(II dinitrate

    Directory of Open Access Journals (Sweden)

    Mario Wriedt

    2010-07-01

    Full Text Available In the title compound, [Ni(C5H5N2(H2O4](NO32, the NiII ion is coordinated by two N-bonded pyridine ligands and four water molecules in an octahedral coordination mode. The asymmetric unit consists of one NiII ion located on an inversion center, as well as one pyridine ligand, one nitrate anion and two water molecules in general positions. In the crystal structure, the discrete complex cations and nitrate anions are connected by O—H...O and C—H...O hydrogen bonds.

  15. 1,1-Dimethylbiguanidium(2+ dinitrate

    Directory of Open Access Journals (Sweden)

    Michaela Fridrichová

    2012-01-01

    Full Text Available In the crystal structure of the title compound, C4H13N52+·2NO3−, the main intermolecular interactions are the N—H...O hydrogen bonds between the cationic amino groups and the O atoms of the nitrate ions. All amino H atoms and nitrate O atoms are involved in the three-dimensional hydrogen-bond network. There are two graph-set motifs R22(8, which include the amino groups connected to the N atoms in the biguanide 3-, 4- and 5-positions, and the O atoms of a nitrate ion. They are extended along the a axis. An O atom of the second nitrate ion is involved in a graph-set motif C(4 that is a part of a helix-like N—H...O...H—N—H...O... chain oriented along the b axis. There are also two weak C—H...O interactions in the crystal structure.

  16. Study on the Clinical Efficacy of Isosorbide Mononitrate Sustained Release Tablets and Compound Danshen Dripping Pills on Unstable Angina in Elder Patients%单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定型心绞痛临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    曾盛芝

    2014-01-01

    Objective: To investigate the clinical efficacy of isosorbide mononitrate sustained release tablets and compound danshen dripping pills on unstable angina in elder patients .Method: A total of 100 elder patients with unstable angina were enrolled in this study .All the 100 cases were divided into two groups:isosorbide mononitrate sustained release tablets control group ( n=50 ) and isosorbide mononitrate sustained release tablets combined with compound danshen dripping pills treatment group ( n=50) .The clini-cal effects and side effects were compared between the two groups .Result:The clinical effective rate in con-trol group and treatment group was 68.0%and 92.0%, respectively.The clinical effective rate in treatment group was higher than that in control group ( P<0.05) .The rate of clinical adverse reactions in control group and treatment group was 30.0%and 12.0%, respectively .The clinical effective rate in treatment group was lower than that in control group ( P<0.05 ) .Conclusion: Isosorbide mononitrate sustained release tablets combined with compound danshen dripping pills showed more effectively clinical efficacy on treating unstable angina elder patients with lower adverse reactions , worthy to promote the clinical application .%目的:观察单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定型心绞痛的临床治疗效果,为老年不稳定型心绞痛的临床治疗提供更多的科学理论依据。方法:收集2011年12月至2012年12月我院心内科收治的老年不稳定型心绞痛患者100例,随机分成2组:单硝酸异山梨酯缓释片治疗对照组(n=50)和单硝酸异山梨酯缓释片联合复方丹参滴丸治疗观察组(n=50)。对照两组的临床疗效、不良反应发生率。结果:对照组和观察组的临床疗效有效率分别为68.0%和92.0%,观察组的临床疗效显著优于对照组( P<0.05)。对照组和观察组的临床不

  17. The Effects of Acupuncture in Treatment of Coronary Heart Diseases

    Institute of Scientific and Technical Information of China (English)

    孟竞壁

    2004-01-01

    A clinical study on acupuncture at point Neiguan (PC 6) was conducted on the basis of successful treatment of patients with angina pectoris and acute myocardial infarct. The effective rate (91.3%) was found to be far superior to isosorbide dinitrate and nifedipine (P<0.01). The experimental studies in animal models demonstrated that electro-acupuncture could decrease the elevated ST segments in ECGs and reduce the infarct areas induced by coronary ligation.

  18. Evaluation on Therapeutic Effect of Compound Danshen Dripping Pills Combined with Isosorbide Mononitrate Tablets Treating Angina Pectoris%复方丹参滴丸联合单硝酸异山梨酯缓释片治疗冠心病心绞痛的综合评价

    Institute of Scientific and Technical Information of China (English)

    梁晓玲

    2013-01-01

    目的:观察复方丹参滴丸联合单硝酸异山梨酯缓释片治疗冠心病心绞痛的临床疗效。方法:选择107例冠心病心绞痛患者分为观察组(53例)与对照组(54例),观察组应用复方丹参滴丸联合单硝酸异山梨酯缓释片的中西医结合治疗方法,对照组单纯应用单硝酸异山梨酯缓释片治疗,4周后对2组患者临床症状、心电图及血液流变学变化情况进行对比分析。结果:观察组心绞痛症状有效率为83.02%,对照组为53.70%,2组差异有统计学意义(P<0.05)。观察组心电图有效率为77.36%,对照组为48.15%,2组差异有统计学意义( P<0.05)。观察组治疗后血流变各项指标均较治疗前下降,其差异均有统计学意义( P<0.05)。对照组治疗后各项指标较治疗前也有一定程度下降,但差异无统计学意义(P>0.05)。结论:复方丹参滴丸联合单硝酸异山梨酯缓释片治疗冠心病心绞痛,对改善心绞痛症状、心电图表现及降低血液黏稠度方面疗效肯定。%Objective:To study the therapeutic effect of compound danshen dripping pills combined with isosorbide mononitrate tablets treating patients with angina pectoris .Methods:One hundred and seven patients with angina pectoris were randomly divided into obser -vation group ( n=53) and control group ( n=54) .Patients in observation group were given compound danshen dripping pills and isosor -bide mononitrate tablets .The control group gave patients isosorbide mononitrate tablets only .After 4 weeks, the clinical symptoms , e-lectrocardiogram and blood rheology changes of the patients were comparatively analyzed between two groups .Results:The effective rate of relieving angina pectoris in the observation group and the control group were respectively 83.02%and 53.70%, which showed signifi-cant differences between the two groups ( P0.05 ) .Conclusion: Com-pound danshen dripping pills combined

  19. Synthesis and protective effect of isosorbide mononitrate acetyl ferulate amide on ischemic myocardium in rats%单硝酸异山梨醇乙酰阿魏酰胺的设计合成及对大鼠缺血心脏保护作用的研究

    Institute of Scientific and Technical Information of China (English)

    冯力; 唐秀玲; 王平安; 王剑波; 孙晓莉

    2012-01-01

    AIM: To design and synthesize isosorbide mononitrate acetyl ferulate amide ( AcFA-201 ) and to study the protective effect of AcFA-201 on myocardial ischemia/reperfusion ( MI/R ) injury in rats. We compared its effect with that of sodium ferulate (SF) , isosorbide mononitrate ( ISMN) and isosorbide mononitrate acetyl ferulic acid ester (AFI) and compared the stability of AFI and AcFA-201 in simulated gastric fluid. METHODS: We first translated the hydroxyl of ISMN into ammo, caused it to react with acetylated ferulic oxychloride and then obtained AcFA-201 with chemical yield of 81. 8%. Male Sprague Dawley rats were subjected to 30 min of myocardial ischemia and 3 h of reperfusion and then randomly received one of the following treatments separately; SF, ISMN, AFI or AcFA-201. The recovery of cardiac function was recorded and serum creatine kinase (CK) activity, lactate dehydrogenase ( LDH ) activity, superoxide dismutase ( SOD) activity, hydrogen peroxide ( H2 O2 ) level, malondialdehyde (MDA) and nitric oxide (NO) content were determined at the end of reperfusion. RESULTS: Synthetic route was feasible and the chemical yield of AcFA-201 was 81. 8%. Studies of the stability in simulated gastric fluid showed that little AFI remained after 10 min and disappeared in 30 min. Meanwhile, AcFA-201 retained the initial drug concentration even 180 min after dosing. Compared with SF and ISMN treatment groups, AcFA-201 treatment group significantly improved cardiac functions as evidenced by increasing left ventricular development pressure ( LVDP) and ± dp/dtmax ( n = 8 , P <0. 05 ), reducing serum CK and LDH activities as well as H2O2 and MDA levels and obviously increasing NO content. However, no significant differences were observed between AcFA-201 group and AFI group. CONCLUSION: AcFA-201 showed a stronger cardioprotective effect against MI/R injury than SF and ISMN and there was no significant difference between AcFA-201 and AFI. AcFA-201 is more stable than AFI in

  20. 普萘洛尔联合5-单硝酸异山梨酯对肝硬化门静脉高压血流动力学参数的影响%The effect of a combined treatment with propranolol and isosorbide-5-mononitrate on hemodynamics parameters in patients with cirrhosis and portal hypertension

    Institute of Scientific and Technical Information of China (English)

    肖华鑫; 王敏; 李健; 田川

    2012-01-01

    目的 探讨普萘洛尔联合5-单硝酸异山梨酯治疗对肝硬化门静脉高压患者血流动力学参数的影响. 方法 30例肝功能Child-Pugh分级A、B级的肝硬化门静脉高压患者随机分为两组,其中普萘洛尔治疗组15例,普萘洛尔联合5-单硝酸异山梨酯治疗组15例,疗程均为48周.所有患者治疗前后均通过超声多普勒显像仪观察门 静脉血流速度( VFP)和门静脉内径(PVD),并计算门静脉充血指数(PCI). 结果 普萘洛尔组治疗前后VFP分别为(12.01±1.75)cm/s和(10.80±1.32)cm/s,PVD分别为(20.73±1.58)mm和(19.53±1.41)mm,差异均有统计学意义(P<0.05),PCI未显著下降(P>0.05);联合组治疗前VFP、PVD和PCI分别为(11.40±1.55)cm/s、(20.87±1.50)mm和(0.2940±0.4561),治疗后分别为(9.60±1.30)cm/s、(15.87±1.19)mm和(0.2107±0.4220),差异均有统计学意义(P均<0.05);两组比较治疗后的VFP、PVD和PCI差异均有统计学意义(P均<0.05). 结论 普萘洛尔联合5-单硝酸异山梨酯较单用普萘洛尔能更有效地降低肝硬化门静脉高压血流动力学参数,具有预防上消化道出血的作用.%Objective To investigate the effect of a combined treatment with propranolol and isosorbide-5-mononitrate on hemodynamics parameters in patients with cirrhosis and portal hypertension. Methods Thirty patients with cirrhosis and portal hypertension, Child-Pugh A B, were randomly divided into two groups. For 48 weeks, one was given propranolol and the other received combined treatment with propranolol and isosorbide-5-mononitrate. In all patients, the velocity of blood flow in the portal vein (VFP) and the cross sectional area of the portal vein (PVD) were determined with Doppler ultrasonography and the portal vein congestion index (PCI) was calculated. Results The group that received propranolol alone had a VFP of (12. 01 + 1. 75)cm/s before treatment and (10. 80±1.32)cm/s afterwards and a PVD of (20. 73±1.58)mm before treatment and (19

  1. Meta-analysis: Nitroglycerin for prevention of post-ERCP pancreatitis

    DEFF Research Database (Denmark)

    Bang, Ulrich Christian; Nøjgaard, C; Andersen, P K

    2009-01-01

    BACKGROUND: Acute pancreatitis after ERCP is a severe side effect. AIM: To evaluate the preventive effect of nitroglycerin on post-ERCP pancreatitis by a meta-analysis of randomized clinical studies. METHODS: We searched on Pubmed, Embase, Cochrane Library and all abstracts presented at Digestive...... Disease Week and United European Gastrointestinal Week from 2004 to 2008. We used the MeSH terms 'pancreatitis' together (AND) with the terms: 'glyceryl trinitrate', 'glyceryl dinitrate', 'isosorbide dinitrate' or 'nitroglycerin'. RESULTS: Five clinical studies evaluating the incidence of post......-ERCP pancreatitis after administration of nitroglycerin were identified. Meta-analysis including all five studies showed a relative risk (RR) of 0.61 (95% CI; 0.44, 0.86) with the number needed to treat (NNT) of 26 (95% CI: 16, 82). Three studies evaluated nitroglycerin administered by a dermal patch reaching...

  2. Bis(pyridine-2-carbaldehyde thiosemicarbazonezinc(II dinitrate dihydrate

    Directory of Open Access Journals (Sweden)

    Jian-Quan Wang

    2010-10-01

    Full Text Available The asymmetric unit of the title compound, [Zn(C7H8N4S2](NO32·2H2O, contains two Zn(pht2 cations (pht is pyridine-2-carbaldehyde thiosemicarbazone, four nitrate anions and four water molecules. In the cations, each ZnII ion adopts a distorted octahedral coordination geometry, being chelated by two tridentate pht ligands. In the crystal, the cations, anions and water molecules are connected via O—H...O and N—H...O hydrogen bonds into a three-dimensional network.

  3. Diaqua(1,10-phenanthrolin-2-olnickel(II dinitrate

    Directory of Open Access Journals (Sweden)

    Qi Sheng Liu

    2009-08-01

    Full Text Available In the mononuclear title complex, [Ni(C12H8N2O2(H2O2](NO32, the NiII ion is coordinated in a distorted octahedral geometry. The dihedral angle between the two mean planes defined by the phenanthroline ligands is 88.26 (6°. Intra- and intermolecular O—H...O hydrogen bonds between the cation and the anions lead to the formation of a layered arrangement parallel to (010.

  4. Nanocapsular forms of preparations in preclinical studies

    Directory of Open Access Journals (Sweden)

    Ekaterina Grinevich

    2010-07-01

    Full Text Available The paper examines preclinical study of nanocapsule deliverysystem, particularly the influence of nanocapsule with a vasodilatorin the process of programmed myocardial cells death. Isosorbidedinitrate was loaded in nanocapsules. To investigate the effectnanocapsule isosorbide dinitrate on the process of apoptosis incardiomyocytes, a series of experimental works wereperformed. For this purpose, a model of coronary insufficiency in 4groups of animals were elaborated. The experimental works onlaboratory animals were conducted in accordance withrequirements of the European Convention for the protection ofvertebrate animals. The first preclinical trials showed the presenceof specific activity of obtained drugs. The basis of nanocapsularsystem was phosphatidylinositol, and the active loading substanceswere alprostadil, interferon alpha.

  5. 单硝酸异山梨酯盐酸伊伐布雷定复方对Beagle犬的长期毒性研究%Experimental Study on the Long-term Toxicity of Isosorbide Mononitrate and Ivabradine Hydrochloride Compound in Beagle Dogs

    Institute of Scientific and Technical Information of China (English)

    胡晓乐; 李会恩; 李斌; 王恩力; 冯中; 赵涛

    2015-01-01

    目的:观察Beagle犬连续30天口服单硝酸异山梨酯盐酸伊伐布雷定复方(ISMN-I)所产生的毒性反应,为临床剂量的拟定提供依据。方法Beagle犬32只,雌雄各半,分为4组:空白对照组,复方低、中、高(30、75、180 mg·kg-1)剂量组,每组8只动物。每日给药1次,连续给药30天,停药观察14天。实验期间,每日进行一般状态观察,每周测定1次体质量及摄食量,于给药前、给药末期及停药恢复期末,各组动物分别进行眼科、体温、尿液、血压、心电图(Ⅱ导联)、血液学指标、血液生化学检测,给药期及恢复期结束剖检并进行病理组织学检查。结果ISMN-I复方高剂量组、中剂量组给药末期可使舒张压(DBP)出现降低,且高剂量组、中剂量组均可导致Beagle犬在给药期间出现呕吐、振颤、抽搐、无力等反应,低剂量组个别犬偶尔出现一次性的呕吐反应。结论本试验条件下,单硝酸异山梨酯盐酸伊伐布雷定复方对Beagle犬无不良反应剂量(NOAEL)为30 mg·kg-1。%Objective To observe the toxicity of isosorbide mononitrate and ivabradine hydrochloride compound (ISMN-I) in beagle dogs, and to provide safety evidences for clinical experiment. Methods 32 healthy beagle dogs, half male and half female, were randomly disvided into control, low-, mid-, and high-dose (30, 75, and 180 mg·kg-1) groups, 8 dogs in each group. The beagle dogs were administered for 30 days, and observed for 14 days after the last administration. During the experiment, the general conditions of animals were observed daily. Body weight and food consumption were weighed weekly. The related indexes including ophthalmology, body temperature, urinary routine, blood pressure, electrocardiogram, hematological and blood biochemical indexes were detected at different time points such as before administration, the end of administration and the end of recovery period

  6. Comparison of four technetium-99m radiopharmaceuticals for detection and localization of gastrointestinal bleeding in a sheep model

    Energy Technology Data Exchange (ETDEWEB)

    Owunwanne, A.; Al-Wafai, I.; Vallgren, S.; Sadek, S.; Abdel-Dayem, H.M.; Yacoub, T.

    1988-01-01

    Four Tc-99 radiopharmaceuticals, Tc-99m sulphur colloid, Tc-99m red blood cells (RBCs), Tc-99m mercaptoacetyltriglycine (MAG3), and Tc-99m DTPA, were studied in an experimental animal model for detection and localization of gastrointestinal (GI) bleeding site in both the upper and lower abdomen. With Tc-99m sulphur colloid and Tc-99m RBCs, it was possible to detect and localize the GI bleeding site in the lower abdomen. With Tc-99m MAG3, it was possible to visualize the bleeding site in both the upper and lower abdomen. However, Tc-99m MAG3 is partially excreted by the liver into the bile, hence it will be difficult to use Tc-99m MAG3 to localize the GI bleeding site in the lower abdomen. With Tc-99m DTPA, it was possible to detect and localize the GI bleeding site simultaneously in both upper and lower abdomen. The overall background radioactivity was reduced considerably by diuresis with frusemide and catheterization of the urinary bladder.

  7. Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease

    Institute of Scientific and Technical Information of China (English)

    JI Hong; GUO Wei-zao; YAN Zhi-hong; LI Di; LU Cui-lian

    2010-01-01

    Background Glucocorticoid signaling exerts major roles in inflammation, metabolism and depression, which are three crucial factors accompanying or underlying coronary heart disease. Although accumulating evidence indicates the influence of glucocorticoids on the pathology and treatment of coronary heart disease, there is still a dearth of pharmaceutical mechanisms for this relationship. This study aimed to investigate the influence of drug treatment on glucocorticoid receptor levels in coronary heart disease.Methods Eighty hospitalized patients (average age (59.0 7.5) years, 46 male and 34 female) with coronary heart disease were categorized into four groups with 20 members in each according to one of the four drugs they were treated with. The four drugs were: nitrated derivative isosorbide dinitrate, the beta-adrenergic receptor blocker metoprolol, the calcium antagonist nifedipine, and the HMG-CoA reductase inhibitor lovastatin. Glucocorticoid receptor protein levels of peripheral blood lymphocytes were tested using immunoblotting analysis before and after one month of treatment. Results Immunoblotting analysis showed increased glucocorticoid receptor levels after treatment with metoprolol and nifedipine. There were no statistically significant changes of glucocorticoid receptor levels after treatment with isosorbide dinitrate or lovastatin, although there were trends of up-regulation of glucocorticoid receptor expression after both treatments.Conclusions Both the beta-blocker and the calcium blocker can increase glucocorticoid receptor levels after chronic administration. This effect suggests a mechanism for their anti-inflammatory and other therapeutic roles for coronary heart disease and comorbid disorders.

  8. Pharmacokinetics of domestic and imported isosorbide mononitrate sustained- release capsule following a single and multiple dose in healthy volunteers%国产和进口单硝酸异山梨酯缓释胶囊单次和多次给药的人体药动学

    Institute of Scientific and Technical Information of China (English)

    黄霞; 陈钧; 荣征星; 蒋新国; 姜昌斌; 陈红专

    2002-01-01

    To compare the pharmacokinetics and relative bioavailability of the domestic and imported sustained-release capsules of isosorbide mononit rate (ISMN) in healthy volunteers. METHODS : The study was performed by an open-label, single-dose and multiple-dose, f our -period crossover design. The plasma-drug concentrations of twenty-two male h ealthy volunteers were determined by gas chromatography with electron-captured detector method(GC-ECD). RESULTS: The ph ar macokinetic parameters after a single oral dose of the domestic and imported ISMN capsules were (5.7±s 0.5) h and (5.8±1.0) h for Tmax, (236 ±62) μg*L-1 and (242±62) μg*L-1 for Cmax , (8.3±1.6 ) h and (8.4±2.1) h for T1/2, (3.7±0.9) mg*h*L-1 and ( 3.6±0.9) mg*h*L-1 for AUC0-36, (4.0±0.9) mg*h*L-1 a nd (3.8± 0.8) mg*h*L-1 for AUC0-∞, (11.5±0.8) h and (11.4±0.7) h for me an residence time (MRT), respectively. The steady-state pharmacokinetic paramet ers after multiple dos e s of the domestic and imported ISMN capsules were (5.2±0.7) h and (5.4±0.9) h for Tmax,(314±67) μg*L-1 and (310±58) μg*L-1 for Cmax,(63±14) μg*L-1 and (65±16) μg*L-1 for C min, (187±38) μg*L-1 and (183±38) μg*L-1 for mean value of steady plasma-drug concentration (Cav),(5.0±1.0) mg*h*L-1 and (4.9±1.0) mg*h*L-1 for AUC0-36, (134±20) % and (134±18 ) % for degree of fluctuation (DF), respectively. The relative bioavailability o f the domestic ISMN capsule to the imported ISMN capsule following a single and multiple dose was (103±11) % a nd (102±9) %, respectively. Main pharmacokinetic parameters between the two form u lations in both single and multiple dose studies showed no statistical differenc e (P>0.05). CONCLUSION: The result of two one side t-test shows that t he two formulations are bioequivalent.%目的: 比较国产和进口单硝酸异山梨酯缓释胶囊的人体药动学和相对生物利用度. 方法: 采用单次和多次给药的4周期双交叉设计,气相色

  9. UPLC - MS/MS法测定比格犬血浆中阿司匹林、水杨酸和单硝酸异山梨酯的浓度%UPLC-MS/MS determination of acetylsalicylic acid, salicylic acid and isosorbide-5-mononitrate in dog plasma

    Institute of Scientific and Technical Information of China (English)

    向志雄; 刘海燕; 孙星; 徐佳珺; 刘文丽

    2012-01-01

    目的:建立灵敏的超高效液相色谱-质谱联用法测定比格犬血浆中的阿司匹林、水杨酸和单硝酸异山梨酯的浓度.方法:选用Waters BEH C18(100 mm ×2.1 mm,1.7 μm)色谱柱,分别以0.5%甲酸/5 mmol· L-1醋酸铵-乙腈和2 mmol·L-1醋酸铵-乙腈为流动相,采用梯度洗脱进行分离,样品采用乙酸乙酯提取后进样,通过电喷雾电离源,以多重反应监测(MRM)方式进行负离子检测,用于定量分析的离子对分别为m/z 178.9→136.9(阿司匹林)、m/z 136.9→64.9(水杨酸)和m/z 293.7→250.0(内标,双氯酚酸钠)测定阿司匹林和水杨酸;m/z 249.6→58.9(单硝酸异山梨酯)和m/z 293.7→250.0(内标,双氯酚酸钠)测定单硝酸异山梨酯.结果:阿司匹林、水杨酸和单硝酸异山梨酯的线性范围分别为2.0 ~ 2000.0,20.0 ~ 16000.0,9.6 ~9557.0 ng·mL-1;定量下限分别可达2.0,20.0,9.6 ng·mL-1;日内、日间精密度(RSD)均小于15%.结论:本方法灵敏度较高,血浆用量少,适用于比格犬血浆样品中阿司匹林、水杨酸和单硝酸异山梨酯的测定和药物动力学研究.%Objective:To develop an UPLC - MS/MS method for determination of acetylsalicylic acid( ASA) and its metabolite(salicylic acid,SA) ,isosorbide -5 - mononitrate(5 -ISMN) in dog plasma. Methods; The dog plasma was extracted by ethyl acetate,and separated on a BEH C18(100 mm × 2. 1 mm,l. 7μm) column by gradient elu-tion using acetonitrile -0. 5% formic acid -5 mmol · L-1 ammonium acetate and acetonitrile -2 mmol · L-1 ammonium acetate as mobile phases respectively. A tandem mass spectrometer equipped with electrospray ionization source was adopted as the detector. Multiple reaction monitoring ( MRM ) transitions of m/z 178. 9→-136. 9, m/z 136. 9→64. 9,m/z 249. 6→58. 9 and m/z 293. 7→250. 0 were measured in negative mode for ASA,SA,5 - ISMN and internal standard,respectively. Results;The linear concentration ranges of the calibration curve for ASA,SA, 5

  10. Use of 99mTc from a commercial 99Mo/9mTc generator as yield tracer for the determination of 99Tc at low levels

    DEFF Research Database (Denmark)

    Hou, Xiaolin; Jensen, Mikael; Nielsen, Sven Poul

    2007-01-01

    cartridges was investigated to purify the eluate to obtain a suitable Tc-99m tracer with low Tc-99 concentration. The activity ratio of Tc-99/Tc-99m in the prepared Tc-99m solution is lower than 15 x 10(-9), which is higher than the theoretical ratio of less than 10 x 10(-9). The possible reason is discussed......) 2007 Elsevier Ltd. All rights reserved....

  11. TECHNETIUM-99M-MAG3 CLEARANCE AS A PARAMETER OF EFFECTIVE RENAL PLASMA-FLOW IN PATIENTS WITH PROTEINURIA AND LOWERED SERUM-ALBUMIN LEVELS

    NARCIS (Netherlands)

    KENGEN, RA; MEIJER, S; BEEKHUIS, H; PIERS, DA

    1991-01-01

    Although the renal clearance of Tc-99m-MAG3 is about 60% of the I-131-hippurate clearance, Tc-99m-MAG3 clearance may be useful to estimate ERPF. In one study, however, proteinuria seemed to influence the MAG3/hippurate clearance ratio. In order to establish whether proteinuria or serum albumin level

  12. Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection

    NARCIS (Netherlands)

    de Graaf, W.; van Lienden, K.P.; Dinant, S.; Roelofs, J.J.T.H.; Busch, O.R.C.; Gouma, D.J.; Bennink, R.J.; van Gulik, T.M.

    2010-01-01

    Tc-99m-mebrofenin hepatobiliary scintigraphy (HBS) was used as a quantitative method to evaluate liver function. The aim of this study was to compare future remnant liver function assessed by Tc-99m-mebrofenin hepatobiliary scintigraphy with future remnant liver volume in the prediction of liver

  13. Drug: D06035 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06035 Drug Technetium Tc 99m gluceptate (USP) Radioactive agent ATC code: V09CA04 ...V09 DIAGNOSTIC RADIOPHARMACEUTICALS V09C RENAL SYSTEM V09CA Technetium (99mTc) compounds V09CA04 Technetium (99mTc) gluce...ptate D06035 Technetium Tc 99m gluceptate (USP) PubChem: 47207693 ...

  14. Department of Defense Report on Search for Human Radiation Experiment Records, 1944 - 1994, Volume 2

    Science.gov (United States)

    1997-06-01

    radioisotope lymphography. A comparison of stannous phytate and antimony sulfide Addendum to Volume I, Appendix I—Records Search 27 IARMY 1944-1,074...of supraclavicular nodes. Although previously published animal data suggested utility of Tc-99m stannous phytate for lymph-node imaging, Tc99m

  15. In vitro properties and in vivo behavior of technetium-99m labeled fibrinogens

    Energy Technology Data Exchange (ETDEWEB)

    Karube, Yoshiharu; Ito, Sanae; Katsuno, Kentaro; Takata, Jiro [Fukuoka Univ. (Japan). Faculty of Pharmaceutical Sciences

    1996-02-01

    Fibrinogen was labeled with Tc-99m by two methods and the in vitro stability and in vivo behavior in mice were studied. The Tc-99m labeling was performed by mixing an unreduced fibrinogen (UnFib) or a reduced fibrinogen (ReFib) with Tc-99m pertechnetate in the presence of stannous chloride. In both of them, chelation with Tc-99m resulted in a single radiochemical product. For the in vitro stability studies, Tc-99m labeled fibrinogen (Tc-99m UnFib) was prepared with UnFib, and transchelation with cysteine solution was easy to produce compared to Tc-99m labeled fibrinogen (Tc-99m ReFib) prepared with ReFib. The radioactivity bound to clottable protein for Tc-99m UnFib and Tc-99m ReFib was about 70% and about 69%, respectively. The in vivo behavior of these labeled fibrinogens was studied, and their efficiencies for imaging an abscess and Ehrlich tumor in mice were determined with a gamma camera. Technetium-99m UnFib underwent a rapid partial exchange of the Tc-99m with compounds of the blood buffer system in vivo, resulting in early urinary excretion. On the other hand, the fraction of Tc-99m ReFib that remained intact in vivo was biologically active and would be incorporated into the abscess and tumor. The uptake in the abscess increased slightly over time with Tc-99m ReFib, but the abscess to blood and abscess to muscle ratios were 0.09 and 2.6 at 5 hr, respectively. Clearly delineated images of the abscess were obtained beginning at about 5 hr after injection. The tumor to blood and tumor to muscle ratios were 0.05 and 1.4 at 5 hr, respectively. The Ehrlich tumor image in mice was slightly visible at 10 hr. The short half-life of Tc-99m was inappropriate for fibrinogen with a low pharmacokinetic value, because it was necessary for imaging of the abscess and tumor to take a long time. (author).

  16. NEW HORIZONS IN THE MANAGEMENT OF HEART FAILURE

    Directory of Open Access Journals (Sweden)

    Puneeta

    2016-04-01

    Full Text Available INTRODUCTION Heart failure (HF is a global problem with an estimated prevalence of 38 million people worldwide; a number that is increasing with the ageing of the population. The heart failure is associated with high health expenditure, mostly because of cost of hospitalisations. The five year survival for individuals with heart failure is about 50%, and in advanced heart failure, the one year survival is as low as 22%, regardless of therapy. The modern history of therapy for heart failure with reduced ejection fraction began with the introduction of vasodilatation with hydralazine plus isosorbide dinitrate. Research about heart failure is now quite active worldwide and many areas are being explored e.g. gene therapy, modification of function of micro RNAs by antagomirs, stem cell therapy besides development of new pharmacological therapeutic agents.

  17. Formation of nitrate and ammonium ions in titanium dioxide mediated photocatalytic degradation of organic compounds containing nitrogen atoms

    Energy Technology Data Exchange (ETDEWEB)

    Low, G.K.-C.; McEvoy, S.R.; Matthews, R.W. (CSIRO Division of Coal and Energy Technology, Menai (Australia))

    1991-03-01

    The photocatalytic oxidation of a related series of primary, secondary, and tertiary amines and other nitrogen- and sulfur-containing organic compounds over a UV-illuminated film of TiO{sub 2} has been studied. The compounds were as follows: n-pentylamine, piperidine, pyridine, phenylalanine, desipramine, thioridazine, penicillamine, isosorbide dinitrate, 4-nitrocatechol, 2,4-dinitrophenol, cyclophosphamide, 5-fluorouracil, atrazine, ethylenediaminetetracetic acid, and tetrabutylammonium phosphate. Both ammonium and nitrate ions were formed. The relative concentration of the two ions depended on the nature of the nitrogen in a compound, but was also influenced by the illumination time and concentration of the solute. It was found that for n-pentylamine, piperidine and pyridine, the rate of formation of ammonium ions was n-pentylamine {much gt} pyridine > piperidine. The order of rates of nitrate formation was pyridine = piperidine {much gt} pentylamine. For n-pentylamine the rate of formation of ammonium ions was {approximately}100 times that of nitrate.

  18. Trial Study on DENG Tie-tao's Coronary Heart Disease Capsules in Improving Patients' Quality of Life

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective: To assess the efficacy of the Coronary Heart Disease (CHD) Capsules worked out by Prof. Deng--in improving quality of life of CHD patients of qi deficiency with phlegm and blood stasis syndrome. Method: According to the WHO's diagnosis criteria of CHD, a total of 93 stable angina patients were divided into 3 groups using the single blinded method. The groups were evenly distributed into CHD Capsule treated group (CHDC), isosorbide dinitrate control group (ID), and Compound Prescription Danshen Droplet Pills control group (CPDDP). Two courses of treatment lasting for 6 months were given. During the courses of treatment, the following parameters were observed: clinical symptoms of angina pectoris, ECG change, treadmill exercise test, 36 items in short form of health survey (SF-36) and Seattle Angina Questionnaire (SAQ) scale. Results: After 6 months of treatment, all the three groups showed good curative effect in angina pectoris, ECG and treadmill exercise test, differences between them had no statistical significance.The CHDC group showed a better result in nitro-glycerine stopping or alleviation rate and in improving symptoms than the other groups (P<0.05). The general health, vitality, role-emotional, mental health and reported health transition in the CHDC group were significantly better than those in the control groups (P<0.05). The scores in physiological functioningrole, physiological function and pain alleviation were not different among the three groups. Conclusion: Prof. DENG Tie-tao's CHDC is effective in treating CHD with qi deficiency, phlegm and blood stasis and also in improving the quality of life. CHDC is more suitable to be used in long-term treatment than isosorbide dinitrate. The SF-36 and SAQ can be used to appraise the curative effect of traditional Chinese medicine agents for CHD angina pectoris.

  19. Improvement of alveolar-capillary membrane diffusing capacity with enalapril in chronic heart failure and counteracting effect of aspirin.

    Science.gov (United States)

    Guazzi, M; Marenzi, G; Alimento, M; Contini, M; Agostoni, P

    1997-04-01

    KII ACE, the enzyme that converts angiotensin I and inactivates bradykinin, is highly concentrated in the lungs; its blockade reduces exposure to angiotensin II and enhances exposure to prostaglandins generated by local kinin hyperconcentration. Our hypothesis is that ACE inhibitors improve pulmonary function in chronic heart failure (CHF) by readjusting lung vessel tone and permeability or alveolar-capillary membrane diffusion. In 16 CHF patients and 16 normal volunteers or mild untreated hypertensives, pulmonary function and exercise tests with respiratory gas analysis were assessed on placebo, enalapril (10 mg BID), enalapril plus aspirin (325 mg/d), or aspirin, in random order and double blind, for 15 days each. In CHF, enalapril increased pulmonary carbon monoxide diffusion (DLCO), oxygen consumption (VO2), and exercise tolerance and reduced the ratio of dead space to tidal volume (VD/VT) and the ventilatory equivalent for carbon dioxide production (VE/VCO2). On enalapril, VO2 (r = .80, P < .0001) and VD/VT (r = -.69, P = .003) changes from placebo correlated with those in DLCO. These effects were inhibited by aspirin and were absent in control subjects. In 8 additional patients, hydralazine-isosorbide dinitrate, as an alternative treatment for reducing pulmonary capillary wedge pressure (PCWP) and increasing exercise capacity, were more effective than enalapril for the PCWP but did not affect DLCO and VE/VCO2; amelioration in VO2 and VD/VT was unrelated to DLCO and was not modified by aspirin. ACE inhibition improved pulmonary diffusion in CHF. Hydralazine-isosorbide dinitrate failed to provide this result. Counteraction by aspirin, a prostaglandin inhibitor, bespeaks prostaglandin participation while on enalapril that might readjust capillary permeability or alveolar-capillary membrane diffusion.

  20. Effects of nitric oxide on gastric ulceration induced by nicotine and cold-restraint stress

    Institute of Scientific and Technical Information of China (English)

    Bo-Sheng Qui; Qi-Bing Mei; Li Liu; Kam-Meng Tchou-Wong

    2004-01-01

    AIM: Stress induces gastric ulceration in human and experimental animals. People tend to smoke more cigarettes when under stress. Nitric oxide (NO) and nicotine have opposing effects on gastric integrity. The present study examined the possible therapeutic benefit of NO in nicotinetreated rats with stress-induced gastric ulceration.METHODS: Rats drank a nicotine solution while control rats drank tap water for 20 days. The alkoloid was then replaced by water with or without supplementation of isosorbide dinitrate (NO donor) for an additional 10 days. Isosorbide dinitrate was given twice shortly before experiments (acute)or three times daily by oral gavages for 10 days after the rats stopped drinking nicotine solution. At the end of experiments,ulcer index, gastric adhesion mucus content and MPO activity were measured and analysed.RESULTS: Nicotine treatment decreased gastric mucus content and intensified stress-induced gastric ulcer. A higher ulcer index persisted even after the rats stopped drinking nicotine solution for 10 days. Acute NO donor showed no benefit on both mucus and ulcer index in nicotine treatment or/and stress condition. Chronic NO donor treatment reversed the worsening action of nicotine in stomach. Stress increased gastric mucosal myeloperoxidase (MPO) activity, which was antagonized by chronic NO treatment. However, nicotine was unlikely to change mucosal MPO activity.CONCLUSION: The intensifying action of nicotine on stressinduced gastric ulceration persists for 10 days after cessation.Nicotine treatment significantly decreases gastric mucus content that can be restored by chronic NO donor treatment.The present study suggests that NO antagonizes the ulcerogenic action of nicotine through a cytoprotective way.

  1. Technetium-99m hexamethylpropylene amine oxime lung scintigraphy findings in low-dose amiodarone therapy.

    Science.gov (United States)

    Kaya, G Capa; Ertay, T; Tuna, B; Bekis, R; Tasci, C; Sayit, E; Yilmaz, O; Kargi, A; Durak, H

    2006-01-01

    Amiodarone (AD)-induced pulmonary toxicity is one of the major complications of long-term AD therapy. Technetium-99m-labeled D: ,L: -hexamethylpropylene amine oxime (Tc-99m HMPAO) scintigraphy has been used to assess lung injury. We designed this study to clarify lung uptake changes of Tc-99m HMPAO using low doses of AD (5 mg/kg/day) during long-term therapy in a rabbit model. Group 1 consisted of 7 rabbits fed with AD by gavage for 6 months. To investigate the effect of ketamine on Tc-99m HMPAO uptake, 5 rabbits were included in Group 2 as a control group. Tc-99m HMPAO scintigraphy was performed in both Group 1 and Group 2 at baseline and after 2, 4, 6, 8, and 12 weeks of AD intake. After 16, 20, and 24 weeks of drug intake, Tc-99m HMPAO scintigraphy was repeated only in group 1. One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. For semiquantitative evaluation, the mean count values were obtained and lung/background and liver/background ratios were calculated. Histopathologic evaluation was performed. No increase in lung and liver uptake of Tc-99m HMPAO was found 2, 4, 6, 8, and 12 weeks after drug intake. There was no significant increase in L/B and H/B ratios of Tc-99m HMPAO in Group 1 compared with Group 2. Both scintigraphic studies and histopathologic examinations showed nonspecific changes. Longitudinal studies investigating Tc-99m HMPAO lung uptake may be planned in patients carrying risk factors for AD-induced lung toxicity.

  2. Characterization of the asynergic myocardium in acute coronary syndrome using simultaneous dual radionuclide emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Sone, Takahito; Tsuboi, Hideyuki; Sassa, Hiromi; Okumura, Yasuki (Ogaki Municipal Hospital, Gifu (Japan))

    1991-01-01

    Phantom and clinical studies were undertaken to determine the value of dual SPECT with Tl-201 and Tc-99m pyrophosphate using a simultaneous collection method in evaluating tissue characterization of ischemic myocardium. Phantom experiments revealed that the residual myocardium was detected from the severity of Tl-201 defect images; the influence of cross talk between two radionuclides was negligible; when the Tc-99m layer was located within 50% inside the phantom wall and the other space was filled with Tl-201 solution, the Tc-99m layer was visualized inwardly more clearly than the Tl-201 layer; and transmural infarction 2 to 2.5 cm in diameter was visualized as the total defect of Tl-201. Taking these results into account, scintigraphic characteristics in 84 patients with acute coronary syndrome were evaluated. Seventeen patients in whom asynergy had nearly resolved in the chronic phase were defined as the group of reversible ischemic myocardial damage. Tl-201 uptake in ischemic lesions was improved in the chronic phase when reinfarction was not seen. Both reduced uptake of Tl-201 and Tc-99m uptake in the subendocardial segment were seen in 43% for nontransmural infarction. Total defect of Tl-201 along with transmural uptake of Tc-99m was the most common for transmural infarction. For unstabler angina pectoris, there was no evidence of Tc-99m PYP uptake. Reduced or normal uptake of Tl-201 combined with negative Tc-99m uptake were dominant for reversible ischemic myocardial damage. Patients having relatively good recovery had a significantly higher prevalence of reduced Tl-201 uptake and subendocardial uptake of Tc-99m and a significantly lower prevalence of the total defect of Tl-201 and transmural uptake of Tc-99m. In conclusion, dual SPECT is useful for predicting reversibility in the early stage of acute coronary syndrome. (N.K.).

  3. Characterization of the antioxidant properties of pentaerithrityl tetranitrate (PETN)-induction of the intrinsic antioxidative system heme oxygenase-1 (HO-1).

    Science.gov (United States)

    Daiber, Andreas; Münzel, Thomas

    2010-01-01

    Organic nitrates are among the oldest and yet most commonly employed drugs in the chronic therapy of coronary artery disease and congestive heart failure. While they have long been used in clinical practise, our understanding of their mechanism of action and of their side effects remains incomplete. To date, the most commonly employed nitrates are isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), and nitroglycerin (GTN). Another nitrate, pentaerithrityl tetranitrate (PETN), has long been employed in eastern European countries and is currently being reintroduced also in western countries. So far, PETN is the only organic nitrate in clinical use, which is devoid of induction of oxidative stress and related side-effects such as endothelial dysfunction and nitrate tolerance. Some of these effects are related to special pharmacokinetics of PETN, but upon chronic administration, PETN also induces antioxidative pathways at the genomic level, resulting in increased expression of heme oxygenase-1 (HO-1) and ferritin, both possessing highly protective properties. There is good experimental evidence that at least part of the beneficial profile of long-term PETN treatment is based on activation of the heme oxygenase-1/ferritin system.

  4. Challenges with nitrate therapy and nitrate tolerance: prevalence, prevention, and clinical relevance.

    Science.gov (United States)

    Thadani, Udho

    2014-08-01

    Nitrate therapy has been an effective treatment for ischemic heart disease for over 100 years. The anti-ischemic and exercise-promoting benefits of sublingually administered nitrates are well established. Nitroglycerin is indicated for the relief of an established attack of angina and for prophylactic use, but its effects are short lived. In an effort to increase the duration of beneficial effects, long-acting orally administered and topical applications of nitrates have been developed; however, following their continued or frequent daily use, patients soon develop tolerance to these long-acting nitrate preparations. Once tolerance develops, patients begin losing the protective effects of the long-acting nitrate therapy. By providing a nitrate-free interval, or declining nitrate levels at night, one can overcome or reduce the development of tolerance, but cannot provide 24-h anti-anginal and anti-ischemic protection. In addition, patients may be vulnerable to occurrence of rebound angina and myocardial ischemia during periods of absent nitrate levels at night and early hours of the morning, and worsening of exercise capacity prior to the morning dose of the medication. This has been a concern with nitroglycerin patches but not with oral formulations of isosorbide-5 mononitrates, and has not been adequately studied with isosorbide dinitrate. This paper describes problems associated with nitrate tolerance, reviews mechanisms by which nitrate tolerance and loss of efficacy develop, and presents strategies to avoid nitrate tolerance and maintain efficacy when using long-acting nitrate formulations.

  5. {4-[(7-Chloro-4-quinolylamino]-N,N-diethylpentanaminium}(triphenylphosphinegold(I dinitrate

    Directory of Open Access Journals (Sweden)

    Marina Hitosugi-Levesque

    2010-09-01

    Full Text Available The title compound, [Au(C18H27ClN3(C18H15P](NO32, is a coordination complex of gold(I triphenylphosphine with the N atom in the quinoline ring of the common antimalarial compound chloroquine (CQ. The pendant diethylamino group of the CQ ligand was found to be protonated. The complex exhibits a nearly linear coordination geometry around the AuI atom [N—Au—P = 176.94 (6°], with Au—N and Au—P bond lengths of 2.070 (2 and 2.2338 (7 Å, respectively. The diethylammonium group and one of the two nitrate counter-ions are disordered with occupancy ratios of 0.519 (4:0.481 (4. The nitrate anions are hydrogen bound to both the amino and ammonium groups of the N,N-diethylpentanaminium fragment of the CQ.

  6. Evaluation of the Toxicokinetic Study of 1,2-Propanediol Dinitrate (PGDN) in the Dog.

    Science.gov (United States)

    1982-05-01

    in light of the assertion that certain MAO inhibitors exert a therapeutic (vasodilation) effect on angina pectoris (Kalin and Kylin, 1969). It was...found that PGDN. EG)N and GTN were competitive inhibitors of MAO activity, while their metabolites showed no such effect. The conclusion was drawn that...the Jaffe kinetic reaction (Larsen, 1972). The serum urea nitrogen technique employed a urease /glutamate dehydrogenase coupled enzyme (Talke and

  7. Tris(1,10-phenanthroline-κ2N,N′nickel(II dinitrate tetrahydrate

    Directory of Open Access Journals (Sweden)

    Masoumeh Tabatabaee

    2011-12-01

    Full Text Available In the title complex, [Ni(C12H8N23](NO32·4H2O, the NiII ion is octahedrally coordinated by three bidentate 1,10-phenanthroline ligands, each forming a five-membered chelate ring. In the crystal, O—H...O and C—H...O hydrogen bonds are present between the complex cations, nitrate anions and water molecules. O—H...O hydrogen bonds between the uncoordinated water molecules lead to the formation of a four-membered ring water cluster, with a planar configuration. There were an additional five grossly disordered water molecules in the asymmetric unit, which were removed by the subroutine SQUEEZE; these were were excluded in the calculation of the molecular weight, etc. π–π stacking interactions between the aromatic rings are also observed [centroid–centroid distances = 3.697 (2, 3.728 (2 and 3.761 (2 Å].

  8. 4-Azaniumyl-2,2,6,6-tetramethylpiperidin-1-ium dinitrate

    Directory of Open Access Journals (Sweden)

    Hammouda Chebbi

    2014-06-01

    Full Text Available In the crystal structure of the title salt, C9H22N22+·2NO3−, the piperidine ring of the dication adopts a chair conformation and the orientation of the C—NH3 bond is equatorial. The ions are linked by normal and bifurcated N—H...O hydrogen bonds in R22(6, two R42(8 and R34(14 graf-set motifs, generating a three-dimensional network.

  9. Tris(phenyl 2-pyridyl ketone oxime-κ2N,N′cadmium(II dinitrate

    Directory of Open Access Journals (Sweden)

    Juan Yan

    2009-06-01

    Full Text Available The Cd atom in the title compound, [Cd(C12H10N2O3](NO32, adopts a distorted octahedral geometry, being ligated by six N atoms from three different phenyl-2-pyridyl ketone oxime ligands. In the crystal structure, intermolecular O—H...O and C—H...O hydrogen bonds link the molecules into a chain structure propagating along [100]. The chains are further linked into a three-dimensional supramolecular structure via van der Waals forces.

  10. Bis{1-[3-(diethylammoniopropyliminomethyl]naphthalen-2-olato}nickel(II dinitrate

    Directory of Open Access Journals (Sweden)

    Xiao-Hui Ji

    2010-08-01

    Full Text Available The asymmetric unit of the title compound, [Ni(C18H24N2O2](NO32, consists of one half of the centrosymmetric nickel(II complex cation and a nitrate anion. The NiII atom, lying on an inversion center, is four-coordinated by the phenolate O atoms and imine N atoms of two Schiff base ligands, forming a square-planar geometry. The O- and N-donor atoms are mutually trans. In the crystal structure, the nitrate anions are linked to the complex cations by intermolecular N—H...O hydrogen bonds.

  11. Diaquabis(pyrazine-2-carboxamide-κ2N1,Ocobalt(II dinitrate

    Directory of Open Access Journals (Sweden)

    Ajay Pal Singh Pannu

    2012-04-01

    Full Text Available The asymmetric unit of the title complex, [Co(C5H5N3O2(H2O2](NO32, contains one half of a CoII cationic unit and a nitrate anion. The entire [Co(C5H5N3O2(H2O2]2+ cationic unit is completed by the application of inversion symmetry at the CoII site, generating a six-coordinate distorted octahedral environment for the metal ion. The chelating pyrazine-2-carboxamide molecules are bound to cobalt via N and O atoms, forming a square plane, while the remaining two trans positions in the octahedron are occupied by two coordinated water molecules.

  12. Poly[[diaquabis(μ2-4,4′-bipyridylcobalt(II] dinitrate tetrahydrate

    Directory of Open Access Journals (Sweden)

    Asma Lehleh

    2013-04-01

    Full Text Available The title compound, {[Co(C10H8N22(H2O2](NO32·4H2O}n, (C10H8N2 = 4,4′-bipyridine = 4,4′-bpy is a layered coordination polymer built up from a cationic square grid extending in (101 enclosing uncoordinating nitrate ions and water molecules. The CoII ion has site symmetry 2 and one of the 4,4′-bpy ligands is generated by twofold symmetry [two N atoms and two C atoms lie on the rotation axis and the dihedral angle between the pyridine rings is 45.66 (5°]. The other 4,4′-bpy ligand is generated by a crystallographic inversion center. The CoII ion exhibits a slightly distorted octahedral coordination geometry defined by two O atoms of two coordinating water molecules and four N atoms from four bridging 4,4′-bpy ligands. The structure is consolidated by O—H...O, C—H...O and C—H...N hydrogen bonds.

  13. Tetraaqua(4,5-diazafluoren-9-one-κ2N,N′nickel(II dinitrate

    Directory of Open Access Journals (Sweden)

    Meng Guo

    2009-11-01

    Full Text Available The title compound, [Ni(C11H6N2O(H2O4](NO32, was prepared by the reaction of Ni(NO32 and 4,5-diazafluoren-9-one (dafo. The crystal packing consists of a three-dimensional network via O—H...O hydrogen bonds between the coordinated water molecules and the nitrate anions. The Ni atom lies on a special position (Wyckoff position 4e, site symmetry 2, as does the carbonyl O atom.

  14. N,N′-Bis(2-aminobenzylethane-1,2-diaminium dinitrate

    Directory of Open Access Journals (Sweden)

    Luis Ángel Garza Rodríguez

    2013-11-01

    Full Text Available In the title salt, C16H24N42+·2NO3−, both the cation and anion are placed in general positions, although the cation displays non-crystallographic inversion symmetry, with the aliphatic chain extended in an all-trans conformation. The benzene rings are almost parallel, with a dihedral angle between their mean planes of 3.3 (6°. The nitrate ions are placed in the vicinity of the protonated amine groups, forming efficient N—H...O inter-ion hydrogen bonds. Each nitrate ion in the asymmetric unit bridges two symmetry-related cations, forming an R44(18 ring, a common motif in organic ammonium nitrate salts. This results in the formation of chains along [010] with alternating cations and anions. The neutral amine groups are involved in slightly weaker N—H...O hydrogen bonds with the nitrate O atoms, and there are also a number of C—H...O hydrogen bonds present. The resulting supramolecular structure is based on a two-dimensional network extending in the ab plane.

  15. Production of radionuclide molybdenum 99 in a distributed and in situ fashion

    Science.gov (United States)

    Gentile, Charles A.; Cohen, Adam B.; Ascione, George

    2016-04-19

    A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator.

  16. Intrasplenic masses of ``preserved`` functioning splenic tissue in sickle cell disease: correlation of imaging findings (CT, ultrasound, MRI, and nuclear scintigraphy)

    Energy Technology Data Exchange (ETDEWEB)

    Levin, T.L. [Department of Radiology, Columbia-Presbyterian Medical Center, Babies and Children`s Hospital of New York, 3959 Broadway, BHN 3-318, New York, NY 10032 (United States); Berdon, W.E. [Department of Radiology, Columbia-Presbyterian Medical Center, Babies and Children`s Hospital of New York, 3959 Broadway, BHN 3-318, New York, NY 10032 (United States); Haller, J.O. [Department of Radiology, SUNY Downstate Medical Center, Brooklyn, New York (United States); Ruzal-Shapiro, C. [Department of Radiology, Columbia-Presbyterian Medical Center, Babies and Children`s Hospital of New York, 3959 Broadway, BHN 3-318, New York, NY 10032 (United States); Hurlet-Jenson, A. [Department of Pediatrics, Columbia-Presbyterian Medical Center, Babies and Children`s Hospital of New York, New York (United States)

    1996-09-01

    Purpose. We studied six patients with sickle cell disease (SSD), five homozygous for sickle cell anemia and one with sickle beta-thalassemia, in whom rounded intrasplenic masses proved to be preserved functioning splenic tissue. Materials and methods. Available images including computed tomography, ultrasonography, bone scans (Tc-99m MDP), liver spleen scans (Tc-99m sulfur colloid), and MRI were evaluated. Results. The masses were low density on CT (in an otherwise calcified spleen), hypoechoic relative to the echogenic spleen on US, and had the imaging characteristics of normal spleen on MRI. They failed to accumulate Tc-99m MDP but did demonstrate uptake of Tc-99m sulfur colloid. Conclusion. In a patient with SSD and intrasplenic masses, proper correlation of multiple imaging modalities will establish the diagnosis of functioning splenic tissue and avoid mistaken diagnosis of splenic abscess or infarction. (orig.). With 2 figs., 1 tab.

  17. Drug: D06031 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06031 Drug Technetium Tc 99m disofenin (USP) Diagnostic aid [hepatobiliary function determination]; Radioac...tive agent ATC code: V09DA01 Component of Hepatolite kit (TN) Anatomical Therapeuti

  18. Single photon emission computed tomography of technetium-99m tetrofosmin myocardial perfusion imaging in patients with systemic lupus erythematosus-A preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Jen-Jhy; Hsu, Hsiu-Bao; Sun, Shung-Shung; Kao, Chia-Hung [China Medical Coll., Taichung, Taiwan (China). Hospital; Wang, Jhi-Joung [Chi-Mei Medical Center, Tainan, Taiwan (China); Ho, Shung-Tai [National Defense Medical Center, Taipei, Taiwan (China). School of Medicine

    2003-01-01

    The purpose of this study was to evaluate the utility of single-photon emission computed tomography (SPECT) of technetium-99m tetrofosmin (Tc-99m TF) myocardial perfusion imaging to detect myocardial involvement in patients with systemic lupus erythematosus (SLE). Three groups of subjects-group 1: 25 SLE female patients with non-specific cardiac symptoms and signs, group 2: 25 female SLE patients without any cardiac symptoms and signs, and group 3: 25 female healthy controls-were evaluated by comparing rest and dipyridamole-stress Tc-99m TF myocardial perfusion SPECT. Tc-99m TF myocardial perfusion SPECT revealed perfusion defects in 88% and 40% of the cases in groups 1 and 2, respectively. However, no cases in group 3 demonstrated myocardial perfusion defects. Tc-99m TF myocardial perfusion SPECT is a useful noninvasive imaging modality to detect cardiac involvement in SLE patients with or without cardiac symptoms and signs. (author)

  19. The cost-effectiveness of sestamibi scanning compared to bilateral neck exploration for the treatment of primary hyperparathyroidism.

    Science.gov (United States)

    Ruda, James; Stack, Brendan C; Hollenbeak, Christopher S

    2004-08-01

    This article presents a cost-effectiveness analysis to determine whether preoperative imaging with Tc99m-sestamibi for detection and treatment of solitary adenomas associated with primary hyperparathyroidism is cost-effective compared with routine bilateral neck exploration.

  20. Incidental Visualization of Thyroid Gland on Bone Scan Caused by Graves' Hyperthyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Jeong, Hwan Jeong; Kim, Dong Wook; Lim, Seok Tae [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2009-04-15

    A 45-year-old man presented with fatigue and weight loss underwent a Tc-99m MDP bone scan because of increased serum alkaline phosphatase. Delayed images at 4 hours demonstrated diffuse increased activity throughout both lobes of the thyroid in the absence of activity of the stomach and salivary glands. Thyroid laboratory indices and a Tc-99m pertechnetate thyroid scan suggested Graves' hyperthyroidism

  1. The Renal Parenchyma Evaluation: MAG3 vs. DMSA

    OpenAIRE

    Smokvina, Aleksandar; Grbac-Ivanković, Svjetlana; Girotto, Neva; Subat Dežulović, Mirna; Saina, Giordano; Miletić Barković, Marina

    2005-01-01

    Scintigraphy with Tc-99m dimercaptosuccinic acid (DMSA) is considered a reference method for assessment of parenchymal lesions and estimation of differential kidney function. The aim of study was to evaluate Tc-99m mercaptoacetyltriglycine (MAG3) dynamic renal scintigraphy for the same purpose. 188 patients, submitted to both studies within three months, were divided in two groups. In the first, 83 DMSA images were compared to parenchymal phase of MAG3 scintigraphy. Kidney morphology was i...

  2. Cintigrama renal DMSA en niños con primera pielonefritis aguda: correlación con exámenes de laboratorio, ecografía y la presencia de reflujo vésico ureteral

    OpenAIRE

    Donoso R,Gilda; Lobo S,Gabriel; Arnello V,Francisca; Arteaga V,María Paz; Hevia J,Pilar; Rosati M,Pía; Lagos R,Elizabeth; Wolff F,Carlos; Pérez R,Andrés; Jiménez J,César

    2004-01-01

    Tc99m DMSA (dimercaptosuccinic acid) scintigraphy has a high sensitivity for the detection of cortical kidney damage. Aim: To evaluate the Tc99m DMSA renal scintigraphy in children with a first episode of acute pyelonephritis and its association with laboratory parameters, kidney ultrasound and vesicoureteral reflux. Patients and methods: We studied 143 children (age range 8 days, 12 years, 66% female) hospitalized with the clinical diagnosis of acute pyelonephritis (first episode) with a pos...

  3. Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression

    Energy Technology Data Exchange (ETDEWEB)

    Buchbender, Christian, E-mail: christian.buchbender@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Sewerin, Philipp, E-mail: philipp.sewerin@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Rheumatology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Mattes-György, Katalin, E-mail: katalin.mattes@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Nuclear Medicine, Moorenstr. 5, D-40225 Dusseldorf (Germany); Miese, Falk, E-mail: falk.miese@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Wittsack, Hans-Joerg, E-mail: hans-joerg.wittsack@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Specker, Christof, E-mail: c.specker@kliniken-essen-sued.de [Department of Rheumatology and Clinical Immunology, Kliniken Essen-Sud, Propsteistrasse 2, D-45239 Essen (Germany); Antoch, Gerald, E-mail: antoch@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Müller, Hans-Wilhelm, E-mail: HansW.Mueller@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Nuclear Medicine, Moorenstr. 5, D-40225 Dusseldorf (Germany); Schneider, Matthias, E-mail: matthias.schneider@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Rheumatology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Scherer, Axel, E-mail: scherer@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf (Germany); Ostendorf, Benedikt, E-mail: ostendorf@med.uni-duesseldorf.de [Univ Dusseldorf, Medical Faculty, Department of Rheumatology, Moorenstr. 5, D-40225 Dusseldorf (Germany)

    2013-02-15

    Objectives: To evaluate the utility of sequentially acquired, post hoc fused, magnetic resonance imaging (MRI) and multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labeled disphosphonates (Tc99m-DPD) for the identification of finger joints with later erosive progression in early rheumatoid arthritis (ERA) patients. Methods: Ten consecutive ERA patients prospectively underwent MPH-SPECT and MRI of metacarpophalangeal (MCP) joints prior to and after 6 months methotrexate therapy. Tc99m-DPD uptake was measured at proximal and distal MCP sites using regional analysis. The course of joint pathologies was scored according to the Rheumatoid Arthritis MRI Score (RAMRIS) criteria. Results: The frequency of increased Tc99m-DPD uptake, synovitis and bone marrow edemadecreased under MTX therapy; but the number of bone erosions increased. Joints with progressive and new erosions on follow-up had a higher baseline Tc99m-DPD uptake (2.64 ± 1.23 vs. 1.43 ± 0.91) (p = 0.02). Conclusions: Joints with erosive progression are characterized by an early increased Tc99m-DPD uptake, even in absence of MRI bone pathologies. Tc99m-DPD MPH-SPECT might thus be of additional value to morphological MRI for the identification of RA patients with a high risk for erosive progression.

  4. Pitfalls and Limitations of Radionuclide Renal Imaging in Adults.

    Science.gov (United States)

    Keramida, Georgia; James, Jacqueline M; Prescott, Mary C; Peters, Adrien Michael

    2015-09-01

    To understand pitfalls and limitations in adult renography, it is necessary to understand firstly the physiology of the kidney, especially the magnitude and control of renal blood flow, glomerular filtration rate and tubular fluid flow rate, and secondly the pharmacokinetics and renal handling of the three most often used tracers, Tc-99m-mercaptoacetyltriglycine (MAG3), Tc-99m-diethylene triamine pentaacetic acid (DTPA) and Tc-99m-dimercaptosuccinic acid (DMSA). The kidneys may be imaged dynamically with Tc-99m-MAG3 or Tc-99m-DTPA, with or without diuretic challenge, or by static imaging with Tc-99m-DMSA. Protocols are different according to whether the kidney is native or transplanted. Quantitative analysis of dynamic data includes measurement of renal vascularity (important for the transplanted kidney), absolute tracer clearance rates, differential renal function (DRF) and response to diuretic challenge. Static image reveals functional renal parenchymal damage, both focal and global, is useful in the clinical management of obstructive uropathy, renal stone disease and hypertension (under angiotensin converting enzyme inhibition), and is the preferred technique for determining DRF. Diagnosis based on morphological appearances is important in transplant management. Even though nuclear medicine is now in the era of hybrid imaging, renal imaging remains an important subspecialty in nuclear medicine and requires a sound basing in applied physiology, the classical supporting discipline of nuclear medicine.

  5. Radionuclide evaluation of kidney allografts in the postoperative follow-up after transplantation; Radionuklidnephrographie zur Verlaufskontrolle nach Nierentransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Bair, H.J. [Erlangen-Nuernberg Univ., Erlangen (Germany). Nuklearmedizinische Klinik mit Poliklinik; Wolf, F. [Erlangen-Nuernberg Univ., Erlangen (Germany). Nuklearmedizinische Klinik mit Poliklinik

    1996-12-01

    The quality of the initial postoperative kidney allograft perfusion is of fundamental importance for the choice of the optimal therapy protocol. Both, perfusion scintigraphy with Tc-99m DTPa and Tc-99m MAG3 and color coded Duplex sonography are comparable and well established modalities to assess kidney transplant perfusion. There is a good correlation between scintigraphic scores and the maximal blood flow velocity in the renal artery. In minimally perfused renal allografts, scintigraphy and color coded Duplex sonography replace angiography for evaluation of very slow blood flow motion. However, color-coded Doppler sonography is much more dependent on the investigator than perfusion scintigraphy. Whereas color-coded Doppler sonography can only evaluate renal transplant perfusion, Tc-99m DTPA or Tc-99m MAG3 scintigraphy is able to evaluate transplant perfusion and function, respectively glomerular filtration or tubular extraction rate. This will be an advantage of scintigraphy. (orig.) [Deutsch] Die Qualitaet der initalen postoperativen Nierentransplantatperfusion ist von fundamentaler Bedeutung fuer die Festlegung eines geeigneten Therapieprotokolls. Die Nierentransplantatperfusionsszintigraphie mittels Tc-99m DTPA und Tc-99m MAG3 und die Farbdopplersonographie sind vergleichbare Untersuchungsmodalitaeten, um die Nierentransplantatperfusion zu erfassen. Es besteht eine gute Korrelation zwischen szintigraphischen Indexmarkern und der dopplersonographisch ermittelten maximalen Blutflussgeschwindigkeit in der A. renalis. Beim minimal durchbluteten Nierentransplantat ersetzen beide Techniken die Angiographie. Im Vergleich zur Perfusionsszintigraphie ist die farbkodierte Dopplersonographie viel mehr untersucherabhaengig. Ueber funktionelle Veraenderungen kann der Farbdoppler nichts oder nur indirekt etwas aussagen. Hier liegt die Staerke der nuklearmedizinischen Perfusions-/Funktionszintigraphie. (orig.)

  6. Clinical evaluation of renal functional dynamic study with [sup 99m]Tc-MAG3; Comparative study with [sup 123]I-OIH using deconvolution analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Shigeki; Kawaguchi, Tatsuya; Takano, Katsuhiro; Tanaka, Naoshi; Nishide, Yoshiya; Takeda, Kan; Hioki, Takuichi; Kawamura, Hisaichi; Nakagawa, Tsuyoshi (Mie Univ., Tsu (Japan). School of Medicine)

    1994-02-01

    A Phase III clinical study compared Tc-99m mercaptoacetylglycylglycylglycine (Tc-99m MAG3) with I-123 orthoiodohippurate (I-123 OIH) in functional radionuclide renal study using deconvolution analysis. The subjects were six patients with diabetic nephropathy, four with renal transplants and seven healthy volunteers. Tc-99m MAG3 tended to give a prolonger transit time than I-123 OIH, although there was no significant correlation between the two radiopharmaceuticals. The shape of the transfer function showed the same distribution pattern of the transit time in Tc-99m MAG3 and I-123 OIH, revealing that both radiopharmaceuticals had the analogous renal dynamics. Regarding effective renal plasma flow, there was a good correlation between the two drug, especially for those with renal transplants. In all patients with renal transplants, defects were seen on functional images when using I-123 OIH, but not seen when using Tc-99m MAG3. This may be attributable to artifacts caused by insufficient dosage of I-123 OIH. Thus Tc-99m MAG3 is considered more useful for evaluating renal function in functional radionuclide imaging because its dosage can be adjusted voluntarily. (N.K.).

  7. Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Karube, Yoshiharu; Katsuno, Kentaro; Ito, Sanae; Matsunaga, Kazuhisa; Takata, Jiro [Fukuoka Univ. (Japan). Faculty of Pharmaceutical Sciences; Kuroki, Masahide; Murakami, Masaaki; Matsuoka, Yuji

    1999-12-01

    The method for subtracting the initial image from the localization image was evaluated for radioimmunoscintigraphy of tumors with technetium-99m (Tc-99m) labeled antibodies. Monoclonal antibodies were parental mouse and mouse-human chimeric antibodies to carcinoembryonic antigen (CEA), designated F11-39 and ChF11-39, respectively, both of which have been found to discriminate CEA in tumor tissues from the CEA-related antigens. After reduction of the intrinsic disulfide bonds, these antibodies were labeled with Tc-99m. In vivo studies were performed on athymic nude mice bearing the human CEA-producing gastric carcinoma xenografts. Though biodistribution results showed selective and progressive accumulation of Tc-99m labeled antibodies at the tumor site, high radioactivity in blood was inappropriate for scintigraphic visualization of the tumors within a few hours. We examined the subtraction of the initial Tc-99m image from the Tc-99m localization image after a few hours. Subtracted images of the same count reflected the in vivo behavior of the Tc-99m radioactivity. The subtracted scintigrams revealed excellent tumor images with no significant extrarenal background. Visualization of the tumor site was dependent on antigen-specific binding and nonspecific exudation. These results demonstrate that a method of subtraction of the initial image may serve as a potentially useful diagnostic method for an abnormal site for agents with a low pharmacokinetic value. (author)

  8. Study of factors that interfere in the labelling process of erythrocytes and plasma proteins with Technetium-99m; Estudo de fatores que interferem no processo de marcacao de hemacias e proteinas plasmaticas com tecnecio-99m

    Energy Technology Data Exchange (ETDEWEB)

    Gutfilen, Bianca

    1989-12-31

    The labelling of red blood cells (RBC) with technetium-99m (Tc-99m) depends on several factors, as the stannous ion (Sn++) concentration, time, temperature, the presence of plasma proteins (PP) and others. However the Sn++ concentration seems to be the most important factor; probably because the uptake of this reducing agent by RBC is limited. The excess of Sn++ in extracellular medium can determine the labelling of PP. the modifications of RBC at 50 deg C described in the literature, the possibility of labelling RBC with Tc-99m at this temperature and experimental results obtained made it possible to perform spleen selective scintigraphy through a simple technique with few manipulations. The effect of gentamicin, nifedipine and verapamil in the labelling of RBC and plasma proteins with Tc-99m was studied because of similarities between Ca++ and Sn++. The results show that, under some conditions, these drugs are capable to alter this Tc-99m incorporation. The modification of the ionic distribution determined by these drugs or the blockage of Sn++ and/or Tc-99m or the fact that they bind theirselves to plasma proteins, or the possibility of the labelling of these drugs, are factors that can interfere in the labelling process of red blood cells and plasma proteins with Tc-99m. (author) 55 refs., 12 figs., 5 tabs.

  9. Effects of nicorandil on cardiac sympathetic nerve activity after reperfusion therapy in patients with first anterior acute myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Kasama, Shu; Toyama, Takuji; Suzuki, Tadashi; Kurabayashi, Masahiko [Gunma University School of Medicine, Department of Cardiovascular Medicine, Maebashi (Japan); Kumakura, Hisao; Takayama, Yoshiaki; Ichikawa, Shuichi [Cardiovascular Hospital of Central Japan, Gunma (Japan)

    2005-03-01

    Ischaemic preconditioning (PC) is a cardioprotective phenomenon in which short periods of myocardial ischaemia result in resistance to decreased contractile dysfunction during a subsequent period of sustained ischaemia. Nicorandil, an ATP-sensitive potassium channel opener, can induce PC effects on sympathetic nerves during myocardial ischaemia. However, its effects on cardiac sympathetic nerve activity (CSNA) and left ventricular remodelling have not been determined. In this study, we sought to determine whether nicorandil administration improves CSNA in patients with acute myocardial infarction (AMI). We studied 58 patients with first anterior AMI, who were randomly assigned to receive nicorandil (group A) or isosorbide dinitrate (group B) after primary coronary angioplasty. The nicorandil or isosorbide dinitrate was continuously infused for >48 h. The extent score (ES) was determined from {sup 99m}Tc-pyrophosphate scintigraphy, and the total defect score (TDS) was determined from {sup 201}Tl scintigraphy 3-5 days after primary angioplasty. The left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) were determined by left ventriculography 2 weeks later. The delayed heart/mediastinum count (H/M) ratio, delayed TDS and washout rate (WR) were determined from {sup 123}I-meta-iodobenzylguanidine (MIBG) images 3 weeks later. The left ventriculography results were re-examined 6 months after treatment. Fifty patients originally enrolled in the trial completed the entire protocol. After treatment, no significant differences were observed in ES or left ventricular parameters between the two groups. However, in group A (n=25), the TDSs determined from {sup 201}Tl and {sup 123}I-MIBG were significantly lower (26{+-}6 vs 30{+-}5, P<0.01, and 32{+-}8 vs 40{+-}6, P<0.0001, respectively), the H/M ratio significantly higher (1.99{+-}0.16 vs 1.77{+-}0.30, P<0.005) and the WR significantly lower (36%{+-}8% vs 44%{+-}12%, P<0.005) than in group B

  10. Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis

    Directory of Open Access Journals (Sweden)

    Murata N

    2015-11-01

    Full Text Available Naotaka Murata,1 Hideaki Aihara,2 Yoshimitsu Soga,1 Yusuke Tomoi,1 Seiichi Hiramori,1 Yohei Kobayashi,1 Kei Ichihashi,1 Nobuhiro Tanaka3 1Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, 2Department of Cardiology, Tsukuba Medical Center Hospital, Ibaraki, 3Department of Cardiology, Tokyo Medical University, Tokyo, Japan Objective: To examine the pressure gradient and peripheral fractional flow reserve (pFFR measured by a pressure wire as indicators of hemodynamic significance in iliofemoral angiographic intermediate stenosis. Background: The utility of pressure measurements using a pressure wire with vasodilators is unclear in cases with intermediate iliofemoral stenosis. Methods: The mean pressure gradient (MPG and mean pressure ratio (MPR were measured at baseline and after injection of isosorbide dinitrate in 23 lesions with angiographically intermediate iliofemoral stenosis. Patients with complex lesions, infrapopliteal artery lesions, chronic total occlusion, and surgical bypass grafts were excluded. Hyperemic MPR was considered equivalent to pFFR. Changes in parameters in response to vasodilators were assessed and correlations of peak systolic velocity ratio (PSVR with hyperemic MPG and pFFR were examined using duplex ultrasound. Results: After injection of isosorbide dinitrate, hyperemic MPG increased significantly (from 9.0±5.7 to 16.3±6.2 mmHg; P<0.05 and hyperemic MPR (pFFR decreased significantly (from 0.92±0.06 to 0.81±0.07; P<0.05. PSVR was significantly correlated with hyperemic MPG (R=0.52; P<0.05 and pFFR (R=–0.50; P<0.05. The optimal cut-off value of pFFR as an indicator of significant hemodynamic stenosis (PSVR >2.5 was 0.85 (area under the curve 0.72; sensitivity 94%; specificity 50%, P<0.05. Conclusion: pFFR measured using a pressure wire is reliable for prediction of hemodynamic significance in iliofemoral intermediate stenosis. Keywords: endovascular therapy, peripheral artery disease, pressure

  11. catena-Poly[[tetraaqua[trans-1,2-bis(4-pyridylethene-κ2N:N′]nickel(II] dinitrate

    Directory of Open Access Journals (Sweden)

    Min Young Hyun

    2011-04-01

    Full Text Available In the title compound, {[Ni(C12H10N2(H2O4](NO32}n, the NiII ion, lying on a crystallographic inversion center, has a distorted octahedral coordination sphere comprising four water ligands and two N-atom donors from the trans-related 1,2-bis(4-pyridylethene ligands, which also have crystallographic inversion symmetry. These ligands bridge the NiII complex units, forming chains extending along the [110] and [overline110] directions. The nitrate counter-anions stabilize the crystal structure through water–nitrate O—H...O hydrogen bonds.

  12. In Vivo Test for Chemical Induction of Micronucleated Polychromatic Erythrocytes in Mouse Bone Marrow Cells, Test Article: Ethylenediamine Dinitrate (EDDN)

    Science.gov (United States)

    2009-08-05

    Testing Guidelines, Subpart F, Section 798.5395, In Vivo mammalian bone marrow cytogenetics tests : Micronucleus Assay. Revised July 1, 2002, (l). OECD...Guideline for Testing of Chemicals, No. 474. Mammalian Erythrocyte Micronucleus Test . Adopted July 21, 1997, (2). International Conference on...mice per dose group per harvest time were used in the Micronucleus Assay. The Range Finding Test was performed at 10, 50, 100, 500, 1000 and 2000

  13. A new polymorph of aquabis(1,10-phenanthroline-κ2N,N′copper(II dinitrate

    Directory of Open Access Journals (Sweden)

    Mehdi Boutebdja

    2014-05-01

    Full Text Available The title molecule, [Cu(C12H8N22(H2O](NO32, is a new polymorph of a compound which up to now has been reported to crystallize space groups in C2/c and Cc. The crystal studied was twinned by non-merohedry (final BASF factor of 0.40043 with the structure being solved and refined in P-1. The CuII atom is coordinated by four N atoms from two 1,10-phenanthroline ligands and an O atom from a water molecule in an approximate trigonal–bipyramidal geometry. Discrete entities of one cation and two nitrate anions are formed by water–nitrate O—H...O hydrogen bonds. The components are further assembled into a three-dimensional network by C—H...O hydrogen bonds.

  14. Bis(2,2′,2′′-nitrilotriacetamide-κ3O,N,O′cobalt(II dinitrate tetrahydrate

    Directory of Open Access Journals (Sweden)

    Jing-Wen Ran

    2013-06-01

    Full Text Available In the centrosymmetric title compound, [Co(C6H12N4O32](NO32·4H2O, the CoII ion, lying on an inversion center, is O,N,O′-chelated by two nitrilotriacetamide molecules, forming a distorted octahedral geometry. In the crystal, extensive O—H...O and N—H...O hydrogen bonds link the complex cations, nitrate anions and lattice water molecules into a three-dimensional network.

  15. Tetraaqua(1,10-phenanthroline-5,6-dione-κ2N,N′cobalt(II dinitrate

    Directory of Open Access Journals (Sweden)

    Wen-Juan Shi

    2009-06-01

    Full Text Available The asymmetric unit of the title compound, [Co(C12H6N2O2(H2O4](NO32, consists of a CoII complex cation with twofold rotational symmetry and two nitrate anions. The CoII atom has a distorted octahedral geometry with the basal plane occupied by two 1,10-phenanthroline-5,6-dione N atoms and two aqua O atoms, with the other two aqua ligands in axial positions. The aqua ligands are involved in extensive hydrogen bonding to nitrate and 1,10-phenanthroline-5,6-dione O atoms.

  16. Synthesis and Crystal Structure of Bis[2-[2-(diethylamino)ethyliminomethyl]-4-nitrophenolato]dimethanolcobalt(Ⅱ) Dinitrate

    Institute of Scientific and Technical Information of China (English)

    WEI Yi-Jun; WANG Feng-Wu; ZHU Qi-Yong

    2006-01-01

    The title mononuclear cobalt(Ⅱ) complex [Co(DENP)2(MeOH)2]·2NO3 (DENP =2-[2-(diethylamino)ethyliminomethyl]-4-nitrophenolate) was prepared and characterized by elemental analysis, IR and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group Pī with a = 8.297(1), b = 11.075(2), c = 11.134(2) (A), α = 69.69(1),β = 70.97(2), γ =84.02(2)°, Z = 1, V = 907.0(4) (A)3, Dc = 1.424 g/cm3, Mr = 777.66, λ(MoKα) = 0.71073 (A), μ = 0.548mm-1, F(000) = 409, R = 0.0628 and wR = 0.1734. The complex consists of a [Co(DENP)2-(MeOH)2]2+ cation and two disordered nitrate anions. The Co atom, lying at the inversion centre, is six-coordinated by two DENP ligands and two MeOH molecules in an octahedral geometry. The molecules in the crystal are linked through intermolecular O-H…O, O-H…N and N-H…O hydrogen bonds, forming chains parallel to the b axis.

  17. Crystal structure of catena-poly[[[trans-bis(acetonitrile-κNdiaquacobalt(II]-μ-pyrazine-κ2N:N′] dinitrate

    Directory of Open Access Journals (Sweden)

    Chen Liu

    2016-02-01

    Full Text Available The central structural motif of the title coordination polymer, [Co(NO32(C4H4N2(CH3CN2(H2O2]n, is a chain composed of CoII ions linked by bis-monodentate bridging pyrazine ligands through their N atoms. The CoII ion is located on an inversion center and is additionally coordinated by two O atoms of water molecules and two N atoms of acetonitrile molecules. The resultant N4O2 coordination sphere is distorted octahedral. The linear cationic chains extend parallel to the a axis and are aligned into layers parallel to the ac plane. Nitrate anions are situated in the space between the CoII chains and form O—H...O hydrogen bonds with the coordinating water molecules, leading to a three-dimensional network structure. Weak C—H...O hydrogen bonds are also present between pyrazine or acetonitrile molecules and the nitrate anions.

  18. Non-visualized Thyroid Gland by Tc-{sup 99m} MIBI Scan with Normal Thyroid Scan

    Energy Technology Data Exchange (ETDEWEB)

    Koca, Gokhan; Atilgan, Hasan Ikbal; Baskin, Aylin; Demirel, Koray; Korkmaz, Meliha [Ankara Training and Research Hospital, Ankara (Turkmenistan)

    2013-09-15

    We present the case of a 21-year-old man who was referred to us for parathyroid scintigraphy with high blood levels of intact parathormone and osteoporosis. Several methods and radiopharmaceuticals, e.g., Tc-99m MIBI and Tl-201 chloride/Tc-99m pertechnetate (Tl-201/TcPO{sup -4}) subtraction, are commonly used for this purpose. We present the case of a thyroid gland that demonstrates quite normal Tc-99m pertechnetate uptake, no accumulation of Tc-99m MIBI, and very low grade Tl-201 uptake. To the best of our knowledge, no similar case has been reported previously. A 21-year-old male with osteoporosis and growth-development retardation was referred for MIBI parathyroid scan because of high blood levels of intact parathormone and bone-specific alkaline-phosphatase, which were 219.4 (15-88 pg/ml) and 355 (21-58 U/L), respectively. In his Tc-99m pertechnetate (TcPO{sup -4}) pinhole scintigraphy, bilateral clearly visualized radioactivity accumulation in the thyroid gland was seen. In both early or late images of the Tc-99m MIBI parathyroid scan, the thyroid gland was not visualized. Therefore, a Tl-201/TcPO{sub -4} subtraction scan method was used. However, the Tl-201 accumulation level in the thyroid gland was not sufficient for the subtraction method. In his thyroid ultrasonography, the thyroid gland echo was homogenous, and there was neither any solid nor cystic lesion. The physical examination of his neck was normal. Other laboratory findings were all normal as follows. TSH: 3.03 (0.35-5.6 IU/mL), free T3: 3.66 (2.5-3.9 pg/mL), free T4: 0.90 (0.59-1.3 ng/dL), Anti-TPO:0.3 (0.40 IU/mL), Anti-TG-Ab: <2.2 (0-+u/L), TSH receptor Ab: 1.0 (0.14 U/L), osteocalcine: 9.13 (1.5-15 ng/dL), growth hormone: 1.3 (0.014-5.21), calcitonin:17 (0.150 ng/mL), sedimentation:6 (0.15 mm/h). There were no significant symptoms of acute or chronic thyroiditis. The cause for discordant uptake in the thyroid gland with T1-201 and Tc-99m MIBI scan could not be provided through clinical or

  19. Regional cerebral hemodynamics during re-build up phenomenon. Analysis by using {sup 99m}Tc-HMPAO SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kazumata, Ken; Kuroda, Satoshi; Houkin, Kiyohiro; Abe, Hiroshi [Hokkaido Univ., Sapporo (Japan). School of Medicine; Mitsumori, Kenji

    1994-12-01

    The re-build up phenomenon is the characteristic EEG finding following hyperventilation in childhood moyamoya disease. This study evaluated the role of cerebral blood flow (CBF) associated with this phenomenon using single photon emission CT (SPECT) with Tc-99m hexamethyl propylene amine oxime (Tc-99m HMPAO). The subjects were each two adult and pediatric patients. Tc-99m HMPAO (10 mCi) was injected immediately after 4-min hyperventilation. After the initial scanning, an additional 20 mCi of Tc-99m HMPAO was iv injected for the second scanning. Xe-133 SPECT was also performed for the evaluation of resting CBF. The re-build up phenomenon was observed preoperatively in one patient, which originated from the bilateral parieto-occipital area one min after hyperventilation and extended to the entire hemisphere 30 sec later. SPECT did not reveal severe ischemia in the entire hemisphere after hyperventilation, but revealed a marked CBF decrease in the bilateral parieto-occipital lobe. The patient underwent bilateral STA-MCA anastomosis combined with encephalo-duro-arterio-myo-synangiosis. Postoperative examination revealed no evidence of build-up phenomenon on EEG or abnormal perfusion reserve on Xe-133 SPECT. Nor was marked CBF decrease observed after hyperventilation on Tc-99m SPECT. These findings suggest that regional CBF decrease may play a critical role in the appearance of the re-build up phenomenon on EEG, as well as hypoxic hypoxia after hyperventilation. (N.K.).

  20. Detection of the involvement of salivary glands in autoimmune diseases of thyroid gland by using Ttc-99m MIBI

    Directory of Open Access Journals (Sweden)

    Deniz Söylemez ¹

    2017-03-01

    Full Text Available Aim: The aim of this study was to determine the involvement in the salivary glands of the patients with Graves’ Disease, Hashimoto Thyroiditis and controls by detecting the changes of Tc-99m Methoxyisobutylisonitrile (Tc-99m MIBI uptake. Material and Methods: The study was conducted between January 2008 and December 2009. 19 patients with Graves’ disease (6 men, 13 women, 28 Hashimoto Thyroiditis patients (5 men, 23 women and 11 euthyroid controls (4 men, 7 women were evaluated retrospectively. Uptake values of parotid and submandibular glands were calculated by drawing elliptical ROIs (region of interest and using the formula for uptake calculation. Result: In all three groups, in parotis glands, a statistical significant difference between Tc-99m MIBI uptake was not detected. The Tc-99m MIBI upateke values in submandibular glands were statistically different among patients with Graves’Disease, Hashimoto Thyroiditis, as well as in Control group (p<0.05. Conclusion: We concluded that the different uptake values of Tc-99m-MIBI in submandibular glands in Graves disease and Hashimoto thyroiditis as compared to the control group patient would be results of the histopathological features, such as autoimmunity, high mitochondria number and inflammatory reaction. [J Contemp Med 2017; 7(1.000: 67-73

  1. A review on the process technology for Mo-99 production

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Hoh; Yoo, Jae Hyung; Jung, Won Myung; Lee, Kyoo Il; Woo, Moon Sik; Hwang, Doo Sung; Kim, Yun Koo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-07-01

    Tc-99m is most frequently used in nuclear medical diagnostics because of its favourable nuclear properties and reasonable prices, and the demand of Tc-99m, is on the increase recently. Mo-99, the parent radionuclide of Tc-99m, is the only source of Tc-99m. This review described overall aspects of process technologies for Mo-99 production. Firstly, the chemical, physical and radioactive properties of Tc-99m, Mo-99 were examined to understand Mo-99 separation process. Also, the technology for Mo-99 production with both the neutron capture and nuclear fission method were examined. But the neutron capture method was scarcely used for large production of Mo-99 because of its low specific activity and high production cost. This review also described mainly process technologies in the nuclear fission method, fabrication and condition for irradiation of targets, transport and dissolution of targets irradiated, separation and purification of Mo-99, etc. Especially, for Mo-99 separation and purification process, the characteristics, merits and demerits of various processes, which have been developed in a few countries, were examined and analyzed. 30 figs., 16 tabs., 60 refs. (Author).

  2. Labeling cellular elements of blood with Technetium-99m

    Energy Technology Data Exchange (ETDEWEB)

    Dewanjee, M.K.

    1990-08-01

    The purpose of this proposal is to develop new technique of labeling platelets and white cells with Tc-99m radionuclide. The conditions of labeling canine platelets and white cells with the lipid-soluble Tc-99m HMPAO have been optimized. The function of labeled platelets were evaluated by the determination of platelet survival time and recovery and these values were compared with that of In-111 tropolone labeled platelets. We developed the bilateral femoral catheterization model for the evaluation of platelet-thrombosis on control and heparin-bonded catheters in dogs. We are evaluating platelet thrombosis in the hollow-fiber hemodialyzer with Tc-99m and In-111 labeled platelets. We have developed the flow-loop for in vitro studies and are using a pig model for quantitation of platelet-consumption during hemodialysis. We are currently evaluating the new technique of platelet and white cell-labeling with Tc-99m and testing them in animal models of thrombosis and infection (osteo-myelitis). We are also using the Tc-99m HMPAO labeled mixed white cells in the early diagnosis (3-hour post-injection) of acute and chronic infection in patients and comparing the results with that of IN-111 oxine labeled white cells.

  3. Production of Medical isotope Technecium-99 from DT Fusion neutrons

    Science.gov (United States)

    Boguski, John; Gentile, Charles; Ascione, George

    2011-10-01

    High energy neutrons produced in DT fusion reactors have a secondary application for use in the synthesis of valuable man-made isotopes utilized in industry today. One such isotope is metastable Technecium-99 (Tc99m), a low energy gamma emitter used in ~ 85% of all medical imaging diagnostics. Tc99m is created through beta decay of Molybdenum-99 (Mo99), which itself has only a 66 hour half-life and must be created from a neutron capture by the widely available and stable isotope Molydenum-98. Current worldwide production of Tc99m occurs in just five locations and relies on obtaining the fission byproduct Mo99 from highly enriched Uranium reactors. A Tc99m generator using DT fusion neutrons, however, could potentially be operated at individual hospitals and medical facilities without the use of any fissile material. The neutron interaction of the DT neutrons with Molybdenum in a potential device geometry was modeled using Monte Carlo neutron transport code MCNP. Trial experiments were also performed to test the viability of using DT neutrons to create ample quantities of Tc99m. Modeling and test results will follow.

  4. Evaluation of isosorbide mononitrate for cervical ripening prior to induction of labor at term pregnancy in an outpatient setting

    Directory of Open Access Journals (Sweden)

    Neelam Meena

    2016-03-01

    Conclusions: IMN self-administered at home is safe and effective for cervical ripening prior to induction of labor in women with term pregnancies. It is the very effective method for cervical ripening in outpatient setup. [Int J Reprod Contracept Obstet Gynecol 2016; 5(3.000: 793-797

  5. Radioisotope production in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Wan Anuar Wan Awang [Medical Technology Div., Malaysian Inst. for Nuclear Technology Research (MINT) (Malaysia)

    1998-10-01

    Production of Mo-99 by neutron activation of Mo-99 in Malaysia began as early as 1984. Regular supply of the Tc-99m extracted from it to the hospitals began in early 1988 after going through formal registration with the Malaysian Ministry of Health. Initially, the weekly demand was about 1.2 Ci of Mo-99 which catered the needs of 3 nuclear medicine centres. Sensitive to the increasing demand of Tc-99m, we have producing our own Tc-99m generator from imported TeO{sub 2} because irradiation TeO{sub 2} with our reactor give low yield of I-131. We have established the production of radioisotope for industrial use. By next year, Sm-153 EDTMP will be produce after we have license from our competent authority. (author)

  6. The prognosis of a normal Tl-201 stress-only SPECT MPI study.

    Science.gov (United States)

    Duvall, W Lane; Hiensch, Robert J; Levine, Elliot J; Croft, Lori B; Henzlova, Milena J

    2012-10-01

    Stress-only Tc-99m SPECT myocardial perfusion imaging (MPI) decreases test time and patient radiation exposure with a proven benign prognosis of a normal study. The imaging sequence of Tl-201 MPI always starts with the stress portion; therefore, no pre-test decisions are needed regarding the imaging sequence. The recent intermittent Tc-99m shortage afforded the unique opportunity to study an unselected group of patients undergoing Tl-201 imaging. We retrospectively reviewed all the patients who had SPECT MPI with Tc-99m or Tl-201 over a 1-year period. When Tc-99m was not available, patients received Tl-201. All stress Tl-201 images were routinely processed, and if normal, rest imaging was not done. When Tc-99m was used, patients with lower pre-test probability were selected for a stress-first protocol. We compared the all-cause mortality of patients with normal Tl-201 studies to those with normal stress-only and rest-stress Tc-99m studies using the Social Security Death Index. Unadjusted and risk-adjusted survival analysis was performed. Specific causes of death (cardiac or non-cardiac) were determined by medical record review and contact with treating physicians. A total of 3,658 patients underwent stress MPI during this time period. Of the 1,215 patients who had Tl-201 MPI, 716 (67%) had a normal stress-only study. Out of 2,443 patients who underwent Tc-99m MPI, 70% had normal perfusion with 1,098 normal stress-only studies and 493 normal rest-stress studies. The average follow-up was 23.3 ± 5.3 months. Unadjusted all-cause mortality at the end of follow-up was 7.1% in the Tl-201 stress-only group, 6.3% for Tc-99m stress-only patients, and 4.3% in the Tc-99m rest-stress cohort. After controlling for confounding variables, survival was similar in the three groups (HR 1.07, 95% CI 0.62-1.82, P = .82 for normal Tl-201 stress-only compared to normal Tc-99m rest-stress). The risk-adjusted 1-year survival was between 98.5 and 98.8% in the three groups. Normal stress

  7. Guarana (Paullinia cupana) effect on radiolabelling of erythrocytes with Technetium-99m; Efeito do guarana (Paulinnia cupana) na marcacao de hemaceas com tecnecio-99m

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Joelma F.; Braga, Ana Cristina S.; Avila, Antonio Sergio R.; Gutfilen, Bianca [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Inst. de Biologia; Bernardo-Filho, Mario [Instituto Nacional do Cancer, Rio de Janeiro, RJ (Brazil)

    1996-07-01

    The labelling of red blood cells (RBC) with technetium-99m (Tc-99m) have been used for many studies in nuclear medicine. This labeling procedure depends on a reducing agent and stannous chloride is normally used for this purpose. Many factors, including drug therapy, can affect the biodistribution of radiopharmaceuticals, such factors many lead to poor organ visualization, requirement to repeat the examination procedure or even misdiagnosis. Guarana (Paullinia cupana) is commonly used in popular medicine. Here, we investigate if guarana is capable to alter the labeling of RBC with Tc-99m and to modify the radioactivity binding to plasma proteins and cellular constituents from insoluble and soluble fractions. The results were obtained with blood samples from Wistar rats with heparine and incubated with different guarana solutions. The percentage of radioactivity (% rad) from BC and P were calculated. The distribution of radioactivity in P and BC showed that the uptake of Tc-99m decreased significantly in all concentrations. (author)

  8. Effect of technetium-99m on iodine-131 thyroid uptake measurements

    Energy Technology Data Exchange (ETDEWEB)

    Wasserman, H.J.; Klopper, J.F.; Erlank, P.

    1985-06-01

    Following administration of 2.5-5.0 mCi(/sup 99m/Tc)pertechnetate, several hundred microcuries may be present in the necks of hyperthyroid patients after 6 hr. Coincidence summing of Tc-99m photons may disturb I-131 uptake measurements in such patients if an oral diagnostic dose of I-131 is administered immediately after completion of a (/sup 99m/Tc)pertechnetate scintigram. Using a lower discriminator level of 300 keV, false increases of 10%-50% may occur at 6 hr. The 24-hr uptake is also affected if an I-131 predose measurement is performed after administration of the Tc-99m dose. The authors have shown that these errors may be prevented by using a 1-mm lead filter in front of the scintillation detector. The attenuation of Tc-99m photons by the filter effectively eliminates summation pulses while it reduces the I-131 count rate by approximately 28%.

  9. Effect of cardiac drugs on imaging studies with thallous chloride Tl 201

    Energy Technology Data Exchange (ETDEWEB)

    Waschek, J.; Hinkle, G.; Basmadjian, G.; Allen, E.W.; Ice, R.

    1981-11-01

    The effects of commonly used cardiac drugs on cardiac imaging with thallium-201-labeled thallous chloride were studied. This retrospective study included 62 men ranging in age from 37 to 70 years who had cardiac imaging attempted with thallium during an eight-month period. Seven drugs were being used by at least eight patients each--propranolol, nitroglycerin ointment, isosorbide dinitrate, digoxin, hydrochlorothiazide, potassium chloride, and quinidine. Myocardial-to-background (M/Bk) ratios were calculated for each patient. No drug consistently affected the M/Bk ratios. The lowest M/Bk ratio was found in patients receiving digoxin, but there was no significant difference between the M/Bk ratios for patients taking digoxin (1.38 +/- 0.16) and those not taking digoxin (1.45 +/- 0.10) (0.05 less than p less than 0.10, Student's t test). It is concluded that the drugs studied do not affect cardiac imaging with thallous chloride Tl 201.

  10. Worsening of coronary spasm during the perioperative period:A case report

    Institute of Scientific and Technical Information of China (English)

    Hiroki; Teragawa; Kenji; Nishioka; Yuichi; Fujii; Naomi; Idei; Takaki; Hata; Shuji; Kurushima; Tomoki; Shokawa; Yasuki; Kihara

    2014-01-01

    We present the case of a 65-year-old male with vasospastic angina(VSA)whose condition worsened during the perioperative period.He had been diagnosed with VSA 10 years prior.He was treated with two types of vasodilators and had not experienced any chest symptoms for 5 years.At this juncture,he underwent surgery for relapsed maxillary sublingual carcinoma.He had taken two vasodilators one day prior to surgery.Intravenous infusion of nitroglycerin(NTG)was initiated immediately before the surgery and continued the following day.Instead of stopping NTG,a dermal isosorbide dinitrate tape was applied on post-operative day 1.Two days later,a complete atrioventricular block with pulseless electrical activity appeared.After cardiopulmonary resuscitation,emergent coronary angiography showed severe coronary spasm in both the left and right coronary arteries.Intracoronary infusion of nitroglycerin and epinephrine with percutaneous cardiopulmonary support relieved the coronary spasm.During the perioperative period,several factors can trigger coronary vasospasm,including the discontinuation of vasodilators.Thus,surgeons,anesthetists,and cardiologists should watch for coronary vasospasm during this period and for worsening coronary spasm when discontinuing vasodilators in patients at risk for VSA.

  11. A novel application of electrospinning technique in sublingual membrane: characterization, permeation and in vivo study.

    Science.gov (United States)

    Chen, Jianting; Wang, Xiaoyu; Zhang, Wenji; Yu, Shihui; Fan, Jinwu; Cheng, Bingchao; Yang, Xinggang; Pan, Weisan

    2016-08-01

    Isosorbide dinitrate-polyvinylpyrrolidone (ISDN-PVP) electrospinning fibers were formulated and explored as potentially sublingual membrane. The addition of polyethylene glycol (PEG) to the formulation improved flexibility and reduced fluffiness of the fiber mat. The scanning electron microscopy (SEM) demonstrated that the fibers tended to be cross-linking, and the crosslinking degree increased with the increase of PEG amount. The differential scanning calorimetry (DSC) indicated that ISDN existed in non-crystalline state in the fibers (except at the highest drug content). The infrared spectroscopy suggested that ISDN had better compatibility with the ingredients owing to the hydrogen bonding (or hydrophobic interactions). The fibers were highly favorable for the fabrication of sublingual membrane due to neutral pH, large folding endurance and rapid drug release (complete dissolution within 120 s). The permeation study of ISDN through both dialysis membrane (DM) and porcine sublingual mucosa (SM) were carried out. A significant relationship of drug permeation rate through DM and SM was built up, which indicated that DM could be used to partly simulate SM and assess formulation. The pharmacokinetic study in rats demonstrated that the electrospinning fiber membrane had a higher Cmax and lower Tmax compared to the reference preparation, and the relative bioavailability of the fiber membrane was 151.6%.

  12. Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice.

    Science.gov (United States)

    Leiter, Jeff R S; Upadhaya, Ritika; Anderson, Judy E

    2012-05-01

    Age-related sarcopenia reduces the size, strength, and function of muscle, and the diameter of muscle fibers. It also disrupts the dystrophin-glycoprotein complex, dislocating nitric oxide synthase 1 (NOS-1) and reducing sarcolemmal integrity. This study of quadriceps muscle in 18-mo-old mice showed that NO-donor treatment with isosorbide dinitrate (I) for 6 wk, in combination with voluntary exercise for 3 wk, increased muscle mass by 25% and stimulated cell proliferation. The resulting fiber hypertrophy was accompanied by a lower ratio of protein:DNA, consistent with myogenic-cell hyperplasia. Treatment enhanced the ratio of NOS-1:β-dystroglycan in correlation with fiber diameter, improved sarcolemmal integrity, and increased vascular density after an increase in vascular endothelial growth factor protein at 3 wk. Results demonstrate that age-related muscle refractoriness to exercise can be overcome with NO-donor treatment. Since activation of muscle stem cells and vascular perfusion are limiting factors in the maintenance, regeneration, and growth of aged muscle, results suggest the feasibility of using NO-donor drugs to combat atrophy and muscle ischemia. Improved function and quality of life from the NO-amplified effects of exercise may be useful in aging and other conditions such as disuse, insulin resistance, or microgravity.

  13. Acute hemodynamic response to vasodilators in primary pulmonary hypertension.

    Directory of Open Access Journals (Sweden)

    Kulkarni H

    1996-01-01

    Full Text Available Acute hemodynamic effects of high flow oxygen (O2 inhalation, sublingual isosorbide dinitrate (ISDN, intravenous aminophylline (AMN and sublingual nifedipine (NIF were studied in 32 patients with primary pulmonary hypertension (PPH. In 30 out of 32 patients the basal ratio of pulmonary to systemic vascular resistance (Rp/Rs was > 0.5 (mean = 0.77 +/- 0.20. Oxygen caused significant decrease in the mean resistance ratio to 0.68 +/- 0.20 (p = 0.005. ISDN, AMN and NIF caused increase in the resistance ratio to 0.79 +/- 0.26; 0.78 +/- 0.26; and 0.80 +/- 0.23 respectively. O2, ISDN, AMN and NIF caused a fall of Rp/Rs in 21 (65.6%, 10 (31.2%, 10(31.2% and 9(28.1% patients respectively. Thus, of the four drugs tested high flow O2 inhalation resulted in fall of Rp/Rs in two thirds of patients whereas ISDN, AMN and NIF caused a mean rise in Rp/Rs. One third of patients did respond acutely to the latter three drugs. Acute hemodynamic studies are useful before prescribing vasodilators in patients with PPH since more of the commonly used drugs like ISDN, AMN, NIF could have detrimental hemodynamic responses in some patients. However, great caution should be exercised before performing hemodynamic study as the procedure has definite mortality and morbidity.

  14. Shexiang Baoxin Pill treatment of elderly patients with chronic stable angina pectoris%麝香保心丸治疗老年慢性稳定性冠心病心绞痛

    Institute of Scientific and Technical Information of China (English)

    刘锋

    2013-01-01

    Objective: To observe the curative ef ect of Shexiang Baoxin Pil in the treatment of elderly patients with chronic coronary heart disease and angina pectoris. Methods:68 patients with coronary heart disease in our hospital, were randomly divided into two groups, the control group oral isosorbide dinitrate, Baoxin Pil containing musk treatment group under the tongue. Results: the treatment group total ef ectiveness 97.1%, the control group the total ef ective 83.8%. Conclusion: the method has obvious curative ef ect, improve the life quality of the patients.%目的:观察麝香保心丸治疗老年慢性冠心病心绞痛的疗效。方法选择本院门诊68例冠心病患者,随机分两组,对照组口服消心痛,治疗组舌下含化麝香保心丸。结果治疗组总有效97.1%,对照组总有效83.8%。结论此法疗效显著,提高患者生活质量。

  15. Evaluation of esophageal intramural pseudo-diverticulosis using high-resolution manometry.

    Science.gov (United States)

    Aimi, Masahito; Mikami, Hironobu; Izumi, Daisuke; Okimoto, Eiko; Tada, Yasumasa; Mishiro, Tsuyoshi; Ishimura, Norihisa; Ishihara, Shunji; Kinoshita, Yoshikazu

    2016-10-01

    Esophageal intramural pseudo-diverticulosis (EIPD) is a rare disease characterized by multiple small flask-shaped pouches in the esophageal wall, with the predominant symptom of chronic progressive or intermittent dysphagia. However, its etiology and pathogenesis remain unknown. We present a case of EIPD evaluated with high-resolution manometry in a 75-year-old man with food impaction after eating beef, who came to our emergency department. The patient experienced similar episodes three times previously, though the cause was unknown. Computed tomography (CT) findings revealed diffuse wall thickness in the upper intrathoracic esophagus, while esophagogastroduodenoscopy showed multiple small depressions and several white plaque patches, and a barium meal esophagogram showed characteristic multiple small outpouching areas. From these findings, we diagnosed the patient with EIPD. In addition, high-resolution manometry revealed strong contractions in the distal esophagus. We started an administration of isosorbide dinitrate, because abnormal esophageal motility may have been causative of the condition and development of pseudo-diverticulosis. Thereafter, the patient had a good clinical course without food impaction. Elevated intra-esophageal luminal pressure caused by abnormal esophageal motility seems to be an important factor in the pathogenesis of EIPD in some cases.

  16. Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

    Science.gov (United States)

    2012-01-01

    Background Radix Salvia miltiorrhiza (Danshen) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI. Methods Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line. Results The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca2+ and inhibiting protein kinase A (PKA). Conclusion SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism. PMID:22409910

  17. Potentiation by isoniazid of relaxation induced by nitrovasodilators in rat aorta.

    Science.gov (United States)

    Vidrio, H; Fernández, G

    1998-09-01

    The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their median effective concentration (EC50) values. Potentiation was minimal with sodium nitrite and increased progressively with sodium nitroprusside, nitroglycerin (NTG), and isosorbide dinitrate. The phenomenon occurred in rings with and without endothelium and was not seen with the nitric oxide-releasing agent acetylcholine or with the nonspecific vasodilator hydralazine. These results confirm previous observations of potentiation of NTG vasorelaxation by ISO and extend them to other nitrovasodilators. Potentiation is attributed to the previously postulated inhibition by ISO of pyridoxal-requiring enzymes involved in the breakdown of homocysteine, leading to its intracellular accumulation. Increased availability of this sulfhydryl donor would lead in turn to enhanced bioactivation and vasorelaxant effects of nitrovasodilators. The different degrees of potentiation observed would be related to the sulfhydryl requirement of each compound for bioactivation. Alternatively, enhanced bioactivation of the nitrovasodilators could be due to induction by ISO of P-450 enzymes involved in this process.

  18. Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity

    Institute of Scientific and Technical Information of China (English)

    LI Guo-feng; Kamiyama Fumio; LIU Li-jie; Yamamoto Akira; CHEN Jian-hai

    2002-01-01

    Objectives: To evaluate the barrier function of different skin layers in the process of percutaneous drug absorption. Methods: In vitro permeability via intact or stripped skin of 6 drugs (5-fluorouracil, theophylline, hydroquinone, barbital, isosorbide dinitrate and ketoprofen) with a wide span of lipophilicity were investigated in the patch dosage forms. Results: Characteristic parabolic relations was observed between the permeability (Kp, cm/h) of the drugs with different lipophilicity and their LogPc via either intact or stripped skin. However, due to the absence of the stratum corneum, increased Kp ratio for the tested drugs was proportional to their solubility in water other than their LogKp. When isopropyl myristate was used as absorption promoter of the drugs, the parabolic relationship no longer existed. For the intact skin, increase of Kp ratio of the drugs was enhanced resulting from IPM as drug's LogPc decreased. On the other hand, in the case of stripped skin, this enhancement was positively related to the solubility of the drugs in IPM. Conclusion: These data and methods present a novel approach to describe percutaneous drug absorption via damaged or diseased skin.

  19. Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

    Directory of Open Access Journals (Sweden)

    Lu Yonghai

    2012-03-01

    Full Text Available Abstract Background Radix Salvia miltiorrhiza (Danshen has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B, a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI effect. This study aims to investigate mechanisms of SA-B on MI. Methods Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line. Results The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP and Ca2+ and inhibiting protein kinase A (PKA. Conclusion SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism.

  20. Stimulant effect of nitric oxide generator and roxatidine on mucin biosynthesis of rat gastric oxyntic mucosa.

    Science.gov (United States)

    Ichikawa, T; Ishihara, K; Kusakabe, T; Kawakami, T; Hotta, K

    1999-01-01

    Although the involvement of nitric oxide (NO) in an increasing gastric mucus metabolism has been reported, information on whether or not its activation is limited to the specific mucus-producing cells is lacking. In this paper, we report the effect of the exogenous NO-donor, isosorbide dinitrate (ISDN), and second-generation histamine H2 receptor antagonist roxatidin