WorldWideScience

Sample records for iso vg polyolesters

  1. Compatibility of manufacturing process fluids with R-134a and polyolester lubricant. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cavestri, R.C.; Schooley, D.L. [Imagination Resources, Inc., Dublin, OH (United States)

    1996-07-01

    This report includes a broad list of processing fluids that are known to be used to manufacture air conditioning and refrigeration products. Sixty-four process fluids from this list were selected for compatibility studies with R-134a and ICI EMKARATE RL32H (32 ISO) polyolester lubricant. Solutions or suspensions of the process fluid residues in polyolester lubricant were heated for 14 days at 175{degrees}C (347{degrees}F) in evacuated sealed glass tubes containing only valve steel coupons. Miscibility tests were performed at 90 wt.% R-134a, 10 wt.% polyolester lubricant with process fluid residue contaminate and were scanned in 10{degrees}C (18{degrees}F) increments over a temperature range of ambient to -40{degrees}C (-40{degrees}F). Any sign of turbidity, haze formation or oil separation was considered the immiscibility point.

  2. Compatibility of manufacturing process fluids with HFC refrigerants and ester lubricants. First draft of final report of part one and quarterly report of part two, January 3, 1994--November 30, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Cavestri, R.C. [Imagination Resources, Inc., Dublin, OH (United States)

    1994-11-01

    Included in this report is a compiled partial list of presently used processing materials in the air-conditioning and refrigeration industry and the manufacturers, intended uses, and applications of each. Also listed are the processing materials that have received final acceptance for this contracted study. An analytical methodology discussion is presented, including the final decision and the limitations of said methodology, as well as how to establish a level of confidence in observed immiscible material components in two 32 ISO VG polyolesters: (1) Mobil EAL Arctic 32; and (2) ICI Emkarate RL32H; both with HFC 134a refrigerant solutions.

  3. ISO 9001 laatujärjestelmän liittäminen osaksi ISM manuaalia

    OpenAIRE

    Koskinen, Ville

    2016-01-01

    Lopputyön aiheena on Turkulaisen varustamon VG-Shipping Oy toimeksiantona selvittää ISO 9001 standardin vaatimusten mukaisten ohjeistuksien liittäminen yrityksen voimassa olevaan turvallisuusjohtamisjärjestelmään (ISM) ja yhdistetyn manuaalin rakentaminen vastaamaan molempien standardien (ISM koodi ja ISO 9001 standardi) vaatimuksia, siten että varustamon alukset eivät ole ISO 9001 luokiteltuja vaan ainoastaan ISM koodin mukaan auditoituja. Lopullisena toimenpiteenä on hyväksyttää ja audit...

  4. Computational study of the vortex path variation with the VG height

    Science.gov (United States)

    Fernández-Gámiz, U.; Zamorano, G.; Zulueta, E.

    2014-06-01

    An extensive range of conventional, vane-type, passive vortex generators (VGs) are in use for successful applications of flow separation control. In most cases, the VG height is designed with the same thickness as the local boundary layer at the VG position. However, in some applications, these conventional VGs may produce excess residual drag. The so-called low-profile VGs can reduce the parasitic drag associated to this kind of passive control devices. As suggested by many authors, low-profile VGs can provide enough momentum transfer over a region several times their own height for effective flow-separation control with much lower drag. The main objective of this work is to study the variation of the path and the development of the primary vortex generated by a rectangular VG mounted on a flat plate with five different device heights h = δ, h1 = 0.8δ, h2 = 0.6δ, h3 = 0.4δ and h4 = 0.25m, where 5 is the local boundary layer thickness. For this purpose, computational simulations have been carried out at Reynolds number Re = 1350 based on the height of the conventional VG h = 0.25m with the angle of attack of the vane to the oncoming flow β = 18.5°. The results show that the VG scaling significantly affects the vortex trajectory and the peak vorticity generated by the primary vortex.

  5. Computational study of the vortex path variation with the VG height

    International Nuclear Information System (INIS)

    Fernández-Gámiz, U; Zamorano, G; Zulueta, E

    2014-01-01

    An extensive range of conventional, vane-type, passive vortex generators (VGs) are in use for successful applications of flow separation control. In most cases, the VG height is designed with the same thickness as the local boundary layer at the VG position. However, in some applications, these conventional VGs may produce excess residual drag. The so-called low-profile VGs can reduce the parasitic drag associated to this kind of passive control devices. As suggested by many authors, low-profile VGs can provide enough momentum transfer over a region several times their own height for effective flow-separation control with much lower drag. The main objective of this work is to study the variation of the path and the development of the primary vortex generated by a rectangular VG mounted on a flat plate with five different device heights h = δ, h 1 = 0.8δ, h 2 = 0.6δ, h 3 = 0.4δ and h 4 = 0.25m, where 5 is the local boundary layer thickness. For this purpose, computational simulations have been carried out at Reynolds number Re = 1350 based on the height of the conventional VG h = 0.25m with the angle of attack of the vane to the oncoming flow β = 18.5°. The results show that the VG scaling significantly affects the vortex trajectory and the peak vorticity generated by the primary vortex

  6. Stk1-mediated phosphorylation stimulates the DNA-binding properties of the Staphylococcus aureus SpoVG transcriptional factor.

    Science.gov (United States)

    Bischoff, Markus; Brelle, Solène; Minatelli, Sabrina; Molle, Virginie

    2016-05-13

    The stage V sporulation protein G (SpoVG) homolog of Staphylococcus aureus is a modulator of virulence factor synthesis and antibiotic resistance in this clinically important gram-positive pathogen. Here we demonstrate that SpoVG can be phosphorylated by the staphylococcal Ser/Thr protein kinase Stk1 and that phosphorylation positively affects its DNA-binding properties. Mass spectrometric analyses and site directed mutagenesis identified Thr4, Thr13, Thr24 and Ser41 as phospho-acceptors. Stk1-mediated phosphorylation markedly enhanced the DNA binding activity of SpoVG towards the promoter regions of target genes such as capA, lip, and nuc1. Similarly, trans-complementation of the S. aureus ΔyabJ-spoVG mutant SM148 with a SpoVG derivative that mimics constitutive phosphorylation, SpoVG_Asp, exhibited capA, lip, and nuc1 transcript levels that were comparable to the levels seen with the wild-type, whereas trans-complementation with a phosphoablative variant of SpoVG (SpoVG_Ala) produced transcript levels similar to the ones seen in SM148. Our data suggest that the expression/activity of this transcription factor is tightly controlled in S. aureus by transcriptional, post-transcriptional and post-translational mechanisms. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Main gas circulator for VG-400 reactor plant

    International Nuclear Information System (INIS)

    Mitenkov, F.M.; Kostin, V.I.; Novinskij, E.G.; Kuropatov, A.I.; Protsenko, A.N.; Smirnov, V.P.; Stolyarevskij, A.Ya.

    1988-01-01

    Principle parameters and operating conditions of the main gas circulator (MGC) in VG-400 reactor plant are presented. Brief MGC design description and experimental work scope are given. (author). 4 refs, 4 figs, 1 tab

  8. The importance of V.G. Levich’s research in the development of modern electrochemistry

    DEFF Research Database (Denmark)

    Ulstrup, J.; Vorotyntsev, M. A.; Davydov, A. D.

    2017-01-01

    The fundamental scientific areas founded and developed by V.G. Levich and his school, and their importance in contemporary theoretical electrochemistry have been overviewed.......The fundamental scientific areas founded and developed by V.G. Levich and his school, and their importance in contemporary theoretical electrochemistry have been overviewed....

  9. VG-400 atomic power and technological installation. Possible core design

    International Nuclear Information System (INIS)

    Komarov, E.V.; Laptev, F.V.; Lyubivyj, A.G.; Mitenkov, F.M.; Samojlov, O.B.; Sukhachevskij, Yu.B.

    1979-01-01

    The main characteristics, basic circuit and configuration of equipment of the VG-400 atomic power and technological installation are considered. This installation is intended for supplying with highly-potential heat of thermal electrochemical hydrogen production and for power generation in the steam-turbine cycle. The main installation characteristics: HTGR reactor heat power 1100 MW, electric power 300 MW, helium coolant pressure 50 atm, output temperature 950 deg C, steam pressure in the second contour 175 atm, temperature 535 deg C, core diameter and height 6.4 m and 4 m, respectively, number of spherical fuel elements 8.5x10 5 . The installation can ensure hydrogen production of 10 5 Nxm 3 /h. For the VG-400 reactor block the integral arrangement of the first circuit equipment in the reinforced concrete is chosen. Two versions of the reactor core with prismatic and spherical fuel elements are compared. It is shown that taking into account great potentialities of the spherical zone in a case of further temperature increase and its positive qualities with respect to construction and processing of fuel elements and graphite blocks, the utilization of simplier units and mechanisms in the overloading system and in the process of profiling of energy distribution the choice of the spherical configuration for the VG-400 pilot plant installation seems to be valid

  10. Hygienic assessment of risk caused by application of graminis ke and rinkor vg herbicides

    Directory of Open Access Journals (Sweden)

    M.M. Vasileva

    2017-12-01

    Full Text Available Our research goal was to perform hygienic assessment of risks caused by Graminis KE and Rinkor VG herbicides for people working with them. We applied sanitary-hygienic and toxicological research techniques in our work in full conformity with valid technical regulatory documents and guidelines. We set the following research tasks: to analyze literature and information sources; to perform primary toxicological assessment of preparatory herbicides and study their acute toxicity together with sensitizing effects at intragastric introduction, cutaneous application, and inhalation exposure on laboratory animals; to examine herbicides cumulative effects and calculation their cumulation coefficient; to examine working conditions during a natural experiment when Graminis KE and Rinkor VG herbicides were applied and calculate risks for workers; to work out scientifically grounded recommendations on their safety application in agriculture. The examined herbicides, Graminis KE and Rinkor VG, are classified as substances with the 3rd hazard degree as per their toxicometric parameters (moderately hazardous substances. Calculated risks of complex (inhalant and dermal exposure to Gramins KE and Rinkor VG herbicides for workers (operators who refills them and those who spray plants with them when they are applied in agriculture don't exceed acceptable levels (are less than 1. Our work results allow to enrich a set of plant protectors which are applied in the country and to use such preparations in agriculture which are the least harmful for health and the environment. Application of Graminis KE and Rinkor VG herbicides will help to increase crops productivity.

  11. Vg mRNA induction in an endangered fish species (Anguilla anguilla) from the Loire estuary (France).

    Science.gov (United States)

    Blanchet-Letrouvé, Isabelle; Lafont, Anne-Gaëlle; Poirier, Laurence; Baloche, Sylvie; Zalouk-Vergnoux, Aurore; Dufour, Sylvie; Mouneyrac, Catherine

    2013-11-01

    Estuarine zones are extremely fragile due to increasing stress from anthropogenic activities. Among those, the Loire estuary (France) is potentially exposed to various contaminants including Endocrine Disruptors Compounds (EDCs) able to impact the reproduction physiology of fish. The European eel (Anguilla anguilla), endangered fish species, is apparently not relevant, in its yellow stage, to monitor the effects of endocrine disruption. Despite this weakly responsiveness, this study aimed to investigate whether European eel from the Loire estuary may still be the subject of estrogenic disruption quantifying the hepatic Vg gene expression according to gender and sexual stage. Vitellogenin (Vg) appears as a valuable biomarker of EDCs, as well as for exposure and effects. Quantitative real-time Reverse Transcription Polymerase Chain Reaction (q RT PCR) was used in this study to amplify responses of hepatic Vg transcripts. European eels were sampled in May 2009 (N=57) and November 2010 (during the downstream migration, N=10) in two sites of the Loire estuary with different ecological conditions and contamination pressures (upstream: Varades; downstream: Nantes). Reproductive (gender, sexual maturity stage) and biometric parameters of collected eels were determined. A laboratory exposure of silver male to steroid hormones (Testosterone (T), 11-KetoTestosterone (11-KT), Estradiol (E2)) was conducted in parallel to validate the q RT PCR approach on hepatic Vg mRNA. Results demonstrated the responsiveness of exposed silver male eels, since hepatic mRNA Vg induction was observed in E2 treated males compared to control specimens. In the field, results of female silver eels reflected large inter-individual differences in the activation of hepatic Vg at silvering. However, while only female silver eels should express hepatic Vg mRNA, quantifiable levels were also detected in a proportion of 38% of the other individuals sampled, normally not inclined to express it, those being

  12. EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1

    Science.gov (United States)

    Cheng, Simon K.; Olale, Felix; Bennett, James T.; Brivanlou, Ali H.; Schier, Alexander F.

    2003-01-01

    The TGF-β signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-β signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-β signaling than anticipated previously. PMID:12514096

  13. Assessment of the CFD capabilities to predict aerodynamic flows in presence of VG arrays

    International Nuclear Information System (INIS)

    Manolesos, Marinos; Papadakis, Giorgos; Voutsinas, Spyros G

    2014-01-01

    Modelling of aerodynamic flows in the presence of vortex generators constitutes a big challenge for CFD due to the different scales involved. The present paper addresses this issue in terms of accuracy and cost. In the simple case of a VG pair placed on a flat plate with no streamwise pressure gradient, the option of fully resolving the VG and that of using the jBAY model are compared with measurements and other CFD simulations. Then the case of 3D separation control on a rectangular wing is considered and comparisons to measurements are performed. Although full resolution of the VGs improves accuracy, the vorticity production is still significantly underestimated, a fact linked with the incapacity of eddy viscosity models to predict vortex flows. It is found that the simulation of one VG pair with periodic side conditions gives fair predictions as long as the VGs keep the flow attached. At angles of attack where 3D separation occurs, this cost effective modelling approach is no longer valid and simulations should include the complete array of VGs. Stereo PIV data showed that close to the VGs (up to 37.2 VG heights downstream of the VGs) turbulent transport between the vortices is strong while further downstream (up to 47.2 heights) diffusion becomes dominant. The normal Reynolds stress distributions also indicate significant vortex wandering in both the normal and spanwise directions

  14. Main characteristics and design features of steam generators for VG-400 plant

    International Nuclear Information System (INIS)

    Golovko, V.F.; Grebennik, V.N.; Gol'tsev, A.O.; Ivanov, S.M.; Sergeev, A.I.; Pospelov, V.N.

    1988-01-01

    The description of a steam generator for the VG-400 plant performed in two variants depending on a heat-exchange surface arrangement (one-bundle coil and module-cassette construction) is given. (author)

  15. Successive carbon- and boron saturation of KhVG steel in powder mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Alimov, Yu A; Gordienko, S I

    1975-01-01

    Method of successive saturation of KhVG steel with carbon and boron in powder mixtures is described. After carbonization of steel in a charcoal carburator at 930 deg C during 3 hrs a domain of equiaxial large grains is formed there the latter representing carbides of Fe/sub 3/C and (Fe, M)/sub 3/C. The increase of duration of carbonization up to 5 hrs and above results in formation of a cement grid greatly impairing the mechanical properties of the metal. Carbonization is followed by borating in powdered technical boron carbide at 900 deg C for 4 hrs which ensures formation on the sample surface of a borated layer with depth up to 65 mkm covering the carbonized zone. As followed from metallographic and x-ray structural analysis, the borated layer consists of boride needles with complex composition (Fe, Cr, Mn)B. Oil hardening of carbonized KhVG steel from 850 deg C and low-temperature tempering at 180 deg C for 1 hr results in formation in the main metal of martensite-carbide structure and, respectively, in the decrease of the microhardness gradient between the diffusion layers, as compared with borated KhVG steel. Operation tests of strengthened matrices of preforming machines under the conditions of application of dynamic pressing forces up to 1500 kg Fce/cm/sup 2/ demonstrated that the cyclical strength of carboborated coverings is 2.0-3.0 times higher than that of borated ones. The method of carboborating is recommended for strengthening the details of stamp and press tools.

  16. Delivery of chitosan/dsRNA nanoparticles for silencing of wing development vestigial (vg) gene in Aedes aegypti mosquitoes.

    Science.gov (United States)

    Ramesh Kumar, D; Saravana Kumar, P; Gandhi, M Rajiv; Al-Dhabi, Naif Abdullah; Paulraj, M Gabriel; Ignacimuthu, S

    2016-05-01

    RNA interference (RNAi) has been used as a gene silencing strategy by the introduction of long double stranded RNA (dsRNA) for the control of pest insects. The aim of the present study was to examine whether the expression of vg gene which is responsible for wing development, can be repressed by chitosan/dsRNA based nanoparticles in Aedes aegypti. The vestigial gene (vg) was amplified from adult mosquito and cloned in pLitmus28i vector. Genetically engineered recombinant plasmid was transformed into RNase III deficient strain for synthesis of bacterially expressed dsRNA. Nanoparticles were prepared via electrostatic interaction between cationic polymer chitosan and anionic nucleic acids (dsRNA). The formation of chitosan/dsRNAnanoparticles and their size were confirmed by Atomic force microscopy (AFM). Chitosan/dsRNA mediated knockdown of Enhanced Green Fluorescence Protein (EGFP) was demonstrated in Sf21 cells. Further, we tested whether such an approach could be used to target vg gene in Ae. aegypti. The results showed that chitosan/dsRNA caused significant mortality, delayed growth development and caused adult wing-malformation. A qRT-PCR analysis confirmed that the chitosan/dsRNA mediated transcriptional level was downregulated. Our findings suggest that vg gene intervention strategies through RNAi can emerge as viable option for pest control. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. ETHNOCULTURAL CONTEXT IN “SIBERIAN TALES” OF V.G. KOROLENKO

    Directory of Open Access Journals (Sweden)

    Oxana Ivanova

    2012-05-01

    Full Text Available The special features of ethnocultural context in the “Siberian Tales” of V.G. Korolenko based on the stories “Makar’s Dream”, “Sokolinets”,“Marusya’s wood house” are analyzed in this paper. The representatives of such nationalities as Yakuts, Russians and Tatars are regarded. The specific peculiarities of the representatives of these nationalities are pointed out. The dependence of the main national character features from the environment, severe climate and Yakut conditions is underlined.

  18. Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens

    Science.gov (United States)

    This study was performed to compare four Clostridium perfringens recombinant proteins as vaccine candidates using the Montanide™ ISA 71 VG adjuvant in an experimental model of necrotic enteritis. Broiler chickens were immunized with clostridial recombinant proteins with ISA 71 VG, and intestinal le...

  19. The international ISOE programme. ISOE European technical centre activities

    International Nuclear Information System (INIS)

    Ascenzo, L. d'; Crouail, P.; Levy, F.; Livolsi, P.; Schieber, C.; Lefaure, C.

    1996-01-01

    The CEPN has been involved from the beginning in the NEA Information System on Occupational Exposure (ISOE). As ISOE European Technical Centre, the CEPN is responsible for the collection and distribution of European data to the various ISOE partners, the collection of data from the other regional technical centres, and the custodianship of the full ISOE data base. This full data base is updated annually and distributed to all the European participating utilities and to other Regional Technical Centres. The European data are also sent to the European Commission (EC) as a contribution to their own occupational exposure data base. In addition to these activities, the CEPN has developed two computer programmes under Windows to facilitate the management of ISOE data bases. The first software, called ASPIC, allows participating utilities to electronically complete NEA1 and NEA3 questionnaires, as well as to consult the NEA3 data base using key words search routine. This software is available in six different languages. The second programme is a relational data base for the performance of statistical analyses using data from NEA1. The CEPN also contributes significantly to the efficient flow of information through the ISOE Network. This includes participation in the preparation and distribution of the ISOE Annual Report (which presents and analyses NEAI data), ISOE Information Sheets (providing short synthesis using NEA1 and NEA3 data), and Technical Reports. Participating Authorities and Utilities have each made information requests to the CEPN concerning dosimetric data, radiation protection experiences, policies and practices. Some examples of these requests, and of the types of data provided, will be presented. (author)

  20. Integrated management system: The integration of ISO 9001, ISO 14001, OHSAS 18001 and ISO 31000

    Science.gov (United States)

    Muzaimi, Hafizzudin; Chew, Boon Cheong; Hamid, Syaiful Rizal

    2017-03-01

    The implementation of integrated management system (IMS) for better quality management has become a preference for many organizations. This can be seen as many organizations used the combination of quality ISO 9001, an environment ISO 14001 and occupational health and safety management system OHSAS 18001 as a core for the IMS that largely implemented. Besides, the linked between quality management with risk management system need to be identified as the management system that enhance the effectiveness of IMS. Therefore, the risk management system ISO 31000 also presented as a part of integration. In nowadays competitive environment, the increasing pressure and needs from customer or stakeholders make it compulsory for the organization to propose the new system and standards. This paper presents and discusses about the benefit of integration, the management system components that can be converged and the implementation approach. A series of interview was conducted through in-depth interviews with 8 experts in this field, while data collected were analyzed qualitatively. The results consist of 16 factors of IMS implementation that have been identified and the use of PDCA approach for an effective implementation of IMS. As a conclusion, the paper proposes the integration of four management systems (ISO 9001, ISO 14001, OHSAS 18001 and ISO 31000) and on how the IMS can be used to structure the process of management for quality management towards sustainability practices in the organization.

  1. ISO27001 / ISO27002 a pocket guide

    CERN Document Server

    Calder, Alan

    2013-01-01

    Information is one of your organisation's most important resources. Keeping it secure is therefore vital to your business. This handy pocket guide is an essential overview of two key information security standards that cover the formal requirements (ISO27001:2013) for creating an Information Security Management System (ISMS), and the best-practice recommendations (ISO27002:2013) for those responsible for initiating, implementing or maintaining it.

  2. IsoBank workshop held at IsoEcol10 - University of Tokyo 2016

    OpenAIRE

    Hayden, Brian

    2016-01-01

    IsoBank is a repository for stable isotope values and relevant metadata. These slides were presented at a workshop held during IsoEcol10 to refine and design the IsoBank for the needs of a diverse group of researchers.

  3. ISO radiation protection standards

    International Nuclear Information System (INIS)

    Becker, K.; West, N.

    1981-01-01

    After a brief description of the International Organization for Standardization (ISO) and its Technical Committee (TC) 85 ''Nuclear Energy'', the work of its Sub-Committee (SC) 2 ''Radiation Protection'' is described in some detail. Several international standards on subjects closely related to radiation protection have already been published, for example ISO-361 (Basic radiation protection symbol), ISO-1757 (Photographic dosimeters), ISO-1758 and 1759 (Direct and indirect-reading pocket exposure meters), ISO-2889 (Sampling of airborne radioactive materials), ISO-4037 (X and gamma reference radiations for calibration) and ISO-4071 (Testing of exposure meters and dosimeters). TC 85/SC 2 has currently eight active Working Groups (WG) dealing with 14 standards projects, mostly in advanced stages, in such fields as neutron and beta reference radiations, and X and gamma radiations of high and low dose-rates and high energies for calibration purposes, reference radiations for surface contamination apparatus, ejection systems for gamma radiography apparatus, industrial and laboratory irradiators, lead shielding units, protective clothing, thermoluminescence dosemeters, radioelement gauges, and surface contamination and decontamination. (author)

  4. ISO radiation sterilization standards

    International Nuclear Information System (INIS)

    Lambert, Byron J.; Hansen, Joyce M.

    1998-01-01

    This presentation provides an overview of the current status of the ISO radiation sterilization standards. The ISO standards are voluntary standards which detail both the validation and routine control of the sterilization process. ISO 11137 was approved in 1994 and published in 1995. When reviewing the standard you will note that less than 20% of the standard is devoted to requirements and the remainder is guidance on how to comply with the requirements. Future standards developments in radiation sterilization are being focused on providing additional guidance. The guidance that is currently provided in informative annexes of ISO 11137 includes: device/packaging materials, dose setting methods, and dosimeters and dose measurement, currently, there are four Technical Reports being developed to provide additional guidance: 1. AAMI Draft TIR, 'Radiation Sterilization Material Qualification' 2. ISO TR 13409-1996, 'Sterilization of health care products - Radiation sterilization - Substantiation of 25 kGy as a sterilization dose for small or infrequent production batches' 3. ISO Draft TR, 'Sterilization of health care products - Radiation sterilization Selection of a sterilization dose for a single production batch' 4. ISO Draft TR, 'Sterilization of health care products - Radiation sterilization-Product Families, Plans for Sampling and Frequency of Dose Audits'

  5. Accreditation - ISO/IEC 17025

    Science.gov (United States)

    Kaus, Rüdiger

    This chapter gives the background on the accreditation of testing and calibration laboratories according to ISO/IEC 17025 and sets out the requirements of this international standard. ISO 15189 describes similar requirements especially tailored for medical laboratories. Because of these similarities ISO 15189 is not separately mentioned throughout this lecture.

  6. Internal Audit Status For ISO 9001 And ISO/ IEC 17025 In Malaysian Nuclear Agency

    International Nuclear Information System (INIS)

    Fazila Said; Nurul Huda Mudri; Nik Arlina Ali

    2012-01-01

    The development of MS ISO 9001 and MS ISO/ IEC 17025 in Malaysian Nuclear Agency is the basic step to enhance and improve the Quality Management System (QMS) for processes and laboratories that involve customers and suppliers in delivering products and services. The effectiveness of QMS is monitored by Research and Innovation Management Centre (RIMC) to ensure that all activities related to audit such as Internal Audit are well organized and implemented as documented in quality manual and procedure. This paper will discuss the status of internal audit for processes that implement MS ISO 9001 and laboratories that accredited with MS/ ISO IEC 17025 in year 2008, 2009 and 2010. The total of non-conformance (nc) and opportunity for improvement (ofi) for processes and laboratories and their numbers as per clause in MS ISO 9001 and MS ISO/ IEC 17025 are the indicators that reflects the effectiveness of QMS. Then, the total effectiveness of QMS for MS 9001 and MS ISO/ IEC 17025 is also determined via the number of conformance clause versus non-conformance clause for those three years. (author)

  7. Food service compliance with ISO 14001 and ISO 22000

    Directory of Open Access Journals (Sweden)

    Laura Lyra Santos

    2012-06-01

    Full Text Available OBJECTIVE: The objective of this study was to assess food service environmental and food safety management systems according to two checklists based on ABNT ISO 22000 and 14001. METHODS: This exploratory and descriptive study investigated a-la-carte food services of the Federal District, Brazil. Two checklists were developed to investigate ISO 14001 and 22000 compliance. A total of 37 food services were selected from the list of the Brazilian Association of Bars and Restaurants by simple random sampling. Checklist results were analyzed according to ANVISA resolution nº 275/2002. RESULTS: Only five food services employed dietitians to supervise meal production. These establishments achieved the highest ISO compliance. However, no establishment had more than 50% ISO 14001 or 22000 compliance. Restaurants showed little concern for the environment and disobeyed waste disposal laws by not separating recyclables from non-recyclables. CONCLUSION: The study food services do not have safe meal production systems, evidenced by non-conformity with the reference standards. Additionally, they do not attempt to reduce the environmental impact of their wastes. Food services supervised by dietitians are better prepared to produce safe foods.

  8. ISO 9000

    International Nuclear Information System (INIS)

    Graham, J.F.

    1992-01-01

    The European Community has adopted the Single European Act. The act states that in order to do business in Europe after 1992, a supplied is expected to be ISO 9000 registered. This paper reports on ISO 9000, which is a systematic approach to implementing a quality system. It is not in the category of technical or product standards, but a standard relating to management of quality in that sector of a company seeking registration. If a company is already systematically practicing quality improvement, these efforts will be applicable to the ISO 9000 certification process. A company will need to refine and update procedures and develop a quality manual. An internal auditing and a corrective action system will also have to be established. The latter addresses audit results, customer complaints, quality system problems, and internal quality improvement suggestions

  9. Tinjauan Kritis Terhadap Implementasi Iso 9000

    OpenAIRE

    Purnama, Nursya’bani

    2005-01-01

    ISO 9000 telah diterima secara luas sebagai acuan sistem manajemen kualitas dan penjaminan kualitas. Perusahaan-Perusahaan yang memperoleh sertifikasi ISO dari tahun ke ke tahun mengalami pertumbu¬han yang pesat. Dengan implementasi dan memperoleh sertifikasi ISO 9000, banyak Perusahaan di dunia mem¬peroleh peningkatan kinerja. Meskipun demikian, implementasi ISO 9000 juga dihadapkan pada sejumlah ham¬batan. Implementasi ISO 9000 seringkali dikaitkan dengan Total Quality Management (TQM). Ban...

  10. The stability of iso-α-acids and reduced iso-α-acids in stored blood specimens.

    Science.gov (United States)

    Rodda, Luke N; Gerostamoulos, Dimitri; Drummer, Olaf H

    2014-06-01

    The long-term stability of the iso-α-acids, and three structurally similar but chemically altered iso-α-acids (known as 'reduced iso-α-acids' and consisting of the rho-, tetrahydro- and hexahydro-iso-α-acid groups) were investigated in whole blood. Pools of blank blood spiked with the four beer-specific ingredient congener groups at two different concentration levels were stored at 20°C, 4°C and -20°C; and extracted in duplicate in weeks 1, 3, 5 and 8, using a previously published method. A loss of 15% of the initial concentration was considered to indicate possible instability and losses greater than 30% demonstrated significant losses. The individual analytes within the four iso-α-acid groups were also measured to determine which iso-α-acids were subject to greater degradation and were responsible for the overall group instability. All four iso-α-acid groups showed significant losses after 8 weeks of storage under room temperature conditions in particularly the natural iso-α-acid group where major losses were observed (96% and 85% losses for low and high concentrations, respectively). Some degradation in all iso-α-acid groups were seen at 4°C samples predominantly due to the 'n' analogs of the groups showing an increased instability in blood. The -20°C storage conditions resulted in minimal changes in concentrations of all analytes. Higher than frozen storage temperatures can result in substantial changes on the stability of the iso-α-acid type groups in blood. The aim of this study was to highlight the stabilities of the IAA analytes in order to assist in the interpretation of IAA in stored blood specimens. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. ISO 14000 : environmental management systems

    International Nuclear Information System (INIS)

    Boutin, C.; Emard, C.; Lalonde, G.; Levesque, A.; Robitaille, R.; Rollin, A.L.; Thibeault, I.

    1996-01-01

    This book is addressed to the managers, professionals, and government agents which wish to know the philosophy of the step as well as the stages to be followed for the establishment of a system of environmental management in conformity with the standards of the series ISO 14000. This work locates ISO 14000 in the historical context of its development by describing the bonds with other standards in place of which those of the series ISO 9000. This book answers questions that arise regarding a companies step toward accreditation to ISO 14000

  12. NDT technical assessment for ISO 17025 and ISO 17020 certification

    International Nuclear Information System (INIS)

    Mohamad Pauzi Ismail

    2011-01-01

    ISO 17025 is an international standard that states the requirement criteria for testing and calibration laboratory, while ISO 17020 is for inspection body. Standard Malaysia is the accreditation body for both standards. The author involved in the technical assessment for both standards both in Nuclear Malaysia and outside. The experience in performing NDT assessment activity is explained and discussed. The comparison between both standards is also discussed. (author)

  13. Explanation and practice on ISO 9000

    International Nuclear Information System (INIS)

    Kwon, Dong Myeong

    2001-01-01

    This book reveals introduction on revision of ISO 9000:2000 with full account and contents of revision and change method change into ISO 9001:2000, the basic principle on ISO 9000:2000 and improvement and aim, definition on explanation, method for detail term, demand for ISO/KS A 9001:2000, quality management system development and transition way, standardization for quality management, manual of quality and making procedure and guide, case of quality manual and procedure and guide and ISO 9001:2000 / KS A 9001:2001 an English-Korean translation.

  14. Laadun- ja riskienhallinta johtamisjärjestelmässä ISO 9001:2015 ja ISO 31000:2009 mukaisesti

    OpenAIRE

    Reinvall, Niko; Karhunen, Joonas

    2015-01-01

    Tämän opinnäytetyön tarkoituksena on tarkastella riskienhallinnan ja laadunhallintajärjestelmien suhdetta ISO 9001:2015 ja ISO 31000:2009-standardien viitekehyksessä, tutkimuskysymyksen ollessa ”miten ja miksi integroida ISO 9001 mukaista laadunhallintaa ja ISO 31000 mukaista riskienhallintaa organisaation johtamisjärjestelmään”. Lisäksi työssä tarkastellaan standardien välisiä yhtymäkohtia ja riskienhallinnan merkitystä ISO 9001:2015 mukaisessa laadunhallintajärjestelmässä. Työn tilaaja...

  15. 75 FR 7581 - RTO/ISO Performance Metrics; Notice Requesting Comments on RTO/ISO Performance Metrics

    Science.gov (United States)

    2010-02-22

    ... performance communicate about the benefits of RTOs and, where appropriate, (2) changes that need to be made to... of staff from all the jurisdictional ISOs/RTOs to develop a set of performance metrics that the ISOs/RTOs will use to report annually to the Commission. Commission staff and representatives from the ISOs...

  16. ISO 639-1 and ISO 639-2: International Standards for Language Codes. ISO 15924: International Standard for Names of Scripts.

    Science.gov (United States)

    Byrum, John D.

    This paper describes two international standards for the representation of the names of languages. The first (ISO 639-1), published in 1988, provides two-letter codes for 136 languages and was produced primarily to meet terminological needs. The second (ISO 639-2) appeared in late 1998 and includes three-letter codes for 460 languages. This list…

  17. Assessment of intraoperative oxygenation function and trauma degree of PCV-VG and VCV mode for elderly patients with laparoscopic abdominal surgery

    Directory of Open Access Journals (Sweden)

    Jun Pu

    2017-03-01

    Full Text Available Objective: To study the intraoperative oxygenation function and trauma degree of pressurecontrolled ventilation-volume guaranteed (PCV-VG and volume-controlled ventilation (VCV mode for elderly patients with laparoscopic abdominal surgery. Methods: 60 elderly patients with laparoscopic abdominal surgery were selected for study and randomly divided into two groups (n=30, group A received ventilation in accordance with sequential VCV-PCV-VG mode, group B received ventilation in accordance with the sequential PCV-VG-VCV mode, and the respiratory function parameters and arterial blood gas parameters and serum damage indexes were determined before the start of pneumoperitoneum (T0, 1 h after the start of the first ventilation mode after the start of pneumoperitoneum (T1, 1 h after the switch of ventilation mode (T2 and after the end of pneumoperitoneum (T3. Results: At T1, Ppeak, mean airway pressure (Pmean and plateau airway pressure (Pplant of group A were significantly higher than those of group B (P<0.05, partial pressure of oxygen (PaO2 was significantly lower than that of group B (P<0.05, and pulse oxygen saturation (SpO2 and partial pressure of carbon dioxide (PaCO2 were not significantly different from those of group B; at T2 and T3, Ppeak, Pmean and Pplant of group A were significantly lower than those of group B (P<0.05, PaO2 were significantly lower than those of group B (P<0.05, and SpO2 and PaCO2 were not significantly different from those of group B. At T1, serum soluble receptor for advanced glycation endproduct (sRAGE, KL-6 (krebs. von den Iungen-6, tumor necrosis factor-α (TNF-α and malondialdehyde (MDA content of group A were significantly higher than those of group B (P<0.05; at T3, serum sRAGE, KL-6, TNF-α and MDA content of group A were significantly lower than those of group B (P<0.05. Conclusions: PCV-VG mode for elderly patients with laparoscopic abdominal surgery can reduce airway pressure, improve lung compliance and

  18. Evaluation of Montanide™ ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis.

    Directory of Open Access Journals (Sweden)

    Seung I Jang

    Full Text Available Chickens were immunized subcutaneously with an Eimeria recombinant profilin protein plus Montanide™ ISA 70 VG (ISA 70 or Montanide™ ISA 71 VG (ISA 71 water-in-oil adjuvants, or with profilin alone, and comparative RNA microarray hybridizations were performed to ascertain global transcriptome changes induced by profilin/ISA 70 vs. profilin alone and by profilin/ISA 71 vs. profilin alone. While immunization with profilin/ISA 70 vs. profilin alone altered the levels of more total transcripts compared with profilin/ISA 71 vs. profilin alone (509 vs. 296, the latter was associated with a greater number of unique biological functions, and a larger number of genes within these functions, compared with the former. Further, canonical pathway analysis identified 10 pathways that were associated with genes encoding the altered transcripts in animals immunized with profilin/ISA 71 vs. profilin alone, compared with only 2 pathways in profilin/ISA 70 vs. profilin alone. Therefore, ISA 71 was selected as a candidate adjuvant in conjunction with profilin vaccination for in vivo disease protection studies. Vaccination with profilin/ISA 71 was associated with greater body weight gain following E. acervulina infection, and decreased parasite fecal shedding after E. maxima infection, compared with profilin alone. Anti-profilin antibody levels were higher in sera of E. maxima- and E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone. Finally, the levels of transcripts encoding interferon-γ, interleukin (IL-2, IL-10, and IL-17A were increased in intestinal lymphocytes from E. acervulina-, E. maxima-, and/or E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone. None of these effects were seen in chickens injected with ISA 71 alone indicating that the adjuvant was not conferring non-specific immune stimulation. These results suggest that profilin plus ISA 71 augments protective immunity

  19. Evaluation of Montanide™ ISA 71 VG Adjuvant during Profilin Vaccination against Experimental Coccidiosis

    Science.gov (United States)

    Lillehoj, Hyun S.; Lee, Sung Hyen; Lee, Kyung Woo; Bertrand, François; Dupuis, Laurent; Deville, Sébastien; Ben Arous, Juliette; Lillehoj, Erik P.

    2013-01-01

    Chickens were immunized subcutaneously with an Eimeria recombinant profilin protein plus Montanide™ ISA 70 VG (ISA 70) or Montanide™ ISA 71 VG (ISA 71) water-in-oil adjuvants, or with profilin alone, and comparative RNA microarray hybridizations were performed to ascertain global transcriptome changes induced by profilin/ISA 70 vs. profilin alone and by profilin/ISA 71 vs. profilin alone. While immunization with profilin/ISA 70 vs. profilin alone altered the levels of more total transcripts compared with profilin/ISA 71 vs. profilin alone (509 vs. 296), the latter was associated with a greater number of unique biological functions, and a larger number of genes within these functions, compared with the former. Further, canonical pathway analysis identified 10 pathways that were associated with genes encoding the altered transcripts in animals immunized with profilin/ISA 71 vs. profilin alone, compared with only 2 pathways in profilin/ISA 70 vs. profilin alone. Therefore, ISA 71 was selected as a candidate adjuvant in conjunction with profilin vaccination for in vivo disease protection studies. Vaccination with profilin/ISA 71 was associated with greater body weight gain following E. acervulina infection, and decreased parasite fecal shedding after E. maxima infection, compared with profilin alone. Anti-profilin antibody levels were higher in sera of E. maxima- and E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone. Finally, the levels of transcripts encoding interferon-γ, interleukin (IL)-2, IL-10, and IL-17A were increased in intestinal lymphocytes from E. acervulina-, E. maxima-, and/or E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone. None of these effects were seen in chickens injected with ISA 71 alone indicating that the adjuvant was not conferring non-specific immune stimulation. These results suggest that profilin plus ISA 71 augments protective immunity against selective

  20. Control: the effects of ISO

    NARCIS (Netherlands)

    Laura Ilzarbe; PhD Everard van Kemenade; Maria-Jezus Alvarez

    2007-01-01

    De effecten van ISO-certificering zoals gerapporteerd in wetenschappelijk onderzoek. Met speciale aandacht voor de resultaten in het onderwijs. ISO 9000:2000 doet het nadrukkelijk beter dan haar vorige versies.

  1. International Organization for Standardization (ISO) 15189.

    Science.gov (United States)

    Schneider, Frank; Maurer, Caroline; Friedberg, Richard C

    2017-09-01

    The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international organization for standardization (ISO) 15189 standard for quality management specific to medical laboratories. CAP leaders offer an overview of ISO 15189 including its components, internal audits, occurrence management, document control, and risk management. The authors provide a comparison of its own ISO 15189 program, CAP 15189, to the CAP Laboratory Accreditation Program. The authors conclude with why laboratories should use ISO 15189. © The Korean Society for Laboratory Medicine.

  2. A practical synthesis of long-chain iso-fatty acids (iso-C12–C19 and related natural products

    Directory of Open Access Journals (Sweden)

    Mark B. Richardson

    2013-09-01

    Full Text Available A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C12–C19 was developed commencing with methyl undec-10-enoate (methyl undecylenate (for iso-C12–C14 or the C15 and C16 lactones pentadecanolide (for iso-C15–C17 and hexadecanolide (for iso-C18–C19. Central to the approaches outlined is the two-step construction of the terminal isopropyl group through addition of methylmagnesium bromide to the ester/lactones and selective reduction of the resulting tertiary alcohols. Thus, the C12, C17 and C18 iso-fatty acids were obtained in three steps from commercially-available starting materials, and the remaining C13–C16 and C19 iso-fatty acids were prepared by homologation or recursive dehomologations of these fatty acids or through intercepting appropriate intermediates. Highlighting the synthetic potential of the iso-fatty acids and various intermediates prepared herein, we describe the synthesis of the natural products (S-2,15-dimethylpalmitic acid, (S-2-hydroxy-15-methylpalmitic acid, and 2-oxo-14-methylpentadecane.

  3. ISO 9000 Quality Management System

    Science.gov (United States)

    Hadjicostas, Evsevios

    The ISO 9000 series describes a quality management system applicable to any organization. In this chapter we present the requirements of the standard in a way that is as close as possible to the needs of analytical laboratories. The sequence of the requirements follows that in the ISO 9001:2008 standard. In addition, the guidelines for performance improvement set out in the ISO 9004 are reviewed. Both standards should be used as a reference as well as the basis for further elaboration.

  4. The European Large Area ISO Survey

    DEFF Research Database (Denmark)

    Oliver, S.; Rowan-Robinson, M.; Alexander, D.M.

    2000-01-01

    We describe the European Large Area ISO Survey (ELAIS). ELAIS was the largest single Open Time project conducted by ISO, mapping an area of 12 deg(2) at 15 mu m with ISOCAM and at 90 mu m with ISOPHOT. Secondary surveys in other ISO bands were undertaken by the ELAIS team within the fields of the...

  5. Mednarodni standardi - veličine in enote (ISO 31-0 do 31-13): International standards - quantities and units (ISO 31-0 to 31-13):

    OpenAIRE

    Glavič, Peter

    2002-01-01

    In this paper the international standards ISO 31 (Quantities and units) are presented with the following parts: ISO 31-0 (General principles), ISO 31-1 (Space and time), ISO 31-2 (Periodic and related phenomena), ISO 31-3 (Mechanics), ISO 31-4 (Heat), ISO 31-5 (Electricity and magnetism), ISO 31-8 (Physical chemistry and molecular physics), ISO 31-12 (Characteristic numbers)and others. The emphasis is given on the basic principles, which is important for writing of reports, presentations, art...

  6. ISO27001 in a Windows Environment

    CERN Document Server

    Honan, Brian

    2010-01-01

    Ideal for project managers, IT and security staff, this book plugs the gap in current guidance literature for ISO27001. ISO27001, the information security management standard (ISMS), is providing a significant challenge for many organisations. One of the key areas of confusion is the relationship between the ISO27001 ISMS project manager and those responsible for implementing the technical controls.

  7. Certification of ISO 9001: SSDL experiences

    International Nuclear Information System (INIS)

    Noriah Mod Ali

    2005-01-01

    Efforts given to maintain the quality management based on the ISO 9000 requirement able to improved the existing system, strengthen the customer confidence and to satisfied the worker needs. It gives direct impact on the harmonization of the Radiation Protection Program in the country. SSDL experiences towards obtaining the the ISO 9002/ISO 9001 certification and its maintenance are discussed in details. (Author)

  8. From ISO 9001:2008 to ISO 9001:2015: Significant changes and their impacts to aspiring organizations

    Science.gov (United States)

    Sari, Y.; Wibisono, E.; Wahyudi, R. D.; Lio, Y.

    2017-11-01

    ISO 9001:2015 is the latest version of ISO Quality Management System standard that has been updated recently from ISO 9001:2008. It is necessary for all organizations that have implemented and been certified with ISO 9001:2008 to prepare the transition and upgrade their Quality Management System because the certification will expire by September 2018. This paper attempts to provide knowledge on the significant changes from ISO 9001:2008 to ISO 9001:2015, what new requirements are added, and how they would impact the organizations. An exploratory and applied research was chosen as the research approach and aimed to explore what transition designs are needed to anticipate the changes as well as their impacts. The research applied a methodology of Plan-Do-Check-Action (PDCA) cycle into four organizations and their results were compared and discussed to explain the transition designs. Some qualitative methods such as observation and interview were used to collect the data. By addressing the new requirements, three transition designs that should be prepared are: (i) identifying needs from interested parties, (ii) analyzing internal and external factors of the organizations to formulate relevant strategies and quality objectives, and (iii) registering risks associated to business processes as well as organizational strategies.

  9. ISO specifications and unclear energy quality certification

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Tae Hun

    2011-12-15

    This book indicates necessity of quality management and change of company environment, basic conception of quality management and thinking way, role of each class for quality management, necessity and purpose of introduction of ISO9000 family, authentication process and construct method of ISO9000 family, authentication effect of ISO9000 family, present condition of ISO9000 family, standard of quality certification and quality management and explanation of 2001 requirement of KSA9000.

  10. ISO specifications and unclear energy quality certification

    International Nuclear Information System (INIS)

    Lee, Tae Hun

    2011-12-01

    This book indicates necessity of quality management and change of company environment, basic conception of quality management and thinking way, role of each class for quality management, necessity and purpose of introduction of ISO9000 family, authentication process and construct method of ISO9000 family, authentication effect of ISO9000 family, present condition of ISO9000 family, standard of quality certification and quality management and explanation of 2001 requirement of KSA9000.

  11. Adopting ISO 9712:2005 and ISO/IEC 17024:2003 as Philippine national standard for NDT for global competitiveness

    International Nuclear Information System (INIS)

    Banaga, Renato T.; Mateo, Alejandro J.

    2005-01-01

    This paper describes and promotes the adoption of ISO 9712: 2005 edition and the ISO/IEC 17024: 2003 edition by the Philippines to be globally competitive. ISO 9712 is a standard for qualifications and certification of nondestructive testing (NDT) personnel while ISO/IEC 17024 is conformity assessment-general requirements for bodies operating certification of persons. ISO 9712 defies that the effectiveness of an application of nondestructive testing depends on the capabilities and qualifications of personnel performing the NDT test. The Philippines through the national certifying body (NCB) implements the certification of proficiency of NDT personnel in accordance with the Philippine National Standards (PNS-146: 1998) This standard (formerly PNS-146: 1987) was originally based from the draft ISO/TC-135/SC7N35.3 and was later revised to conform to the latest ISO FDIS 9712: 1997 and rename PNS-146: 1998. Now with the issuance of the latest ISO 9712:2005 edition and to keep abreast with the current trends of NDT technology, present time and conditions dictates for us to revise our NDT personnel certification to the latest edition of ISO 9712. The International Atomic Energy Agency (IAEA) supports the establishment of a common NDT standard. The IAEA is promoting af financially supporting the establishment in developing countries of only one NDT standard. The IAEA through the Regional Cooperative Agreement (RCA) has initiated the harmonization of the NDT qualification and certification of personnel in the RCA member states. In October 2001, the IAEA sponsored the Dhaka meeting where the International Committee for Nondestructive Testing (ICNDT), Asia-Pacific Committee (APCNDT) and RCA member states representatives drafted a Mutual Recognition Agreement (MRA) for the Asia-Pacific NDT (APCNDT) personnel certification schemes acording to ISO 9712. Last August 2005, IAEA/RCA sponsored the Colombo meeting for the harmonization of regional NDT applying ISO 9712 and ISO

  12. Promoting Strong ISO 50001 Outcomes with Supportive National Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    McKane, Aimee, T.; Siciliano, Graziella; de los Reyes, Pamela

    2015-08-04

    The ISO 50001 standard is a key mechanism for reducing greenhouse gas emissions and improving energy efficiency globally. An increasing number of companies are seeking certification, creating the need for personnel that are competent to conduct ISO 50001 certification audits. The growth of ISO 50001 is expected to accelerate as more companies integrate ISO 50001 into their corporate sustainability strategies and supplier requirements. Robust implementation of ISO 50001 represents an important tool for countries with climate change mitigation goals. Because of its dual focus on continual improvement of an organization’s energy management system (EnMS) and its energy performance improvement, ISO 50001 requires skills of both implementers and certification auditors that are not well-supported by current credentials and training. This paper describes an effort to address skill gaps of certification auditors, a critical factor to ensure that ISO 50001 implementations are robust and result in continued energy performance improvement. A collaboration of governments through the Energy Management Working Group (EMWG), formerly under Global Superior Energy Performance (GSEP), has formed to build workforce capacity for ISO 50001 certification audits. The EMWG is leading the development of an internationally-relevant certification scheme for ISO 50001 Lead Auditor that meets requirements for ISO/IEC 17024 accreditation and ISO 50003 for defining ISO 50001 Lead Auditor competency. Wider availability of competent ISO 50001 Lead Auditors will ultimately increase the impact and market value of ISO 50001 certification and improve consistency of ISO 50001 certification outcomes by establishing a standardized and high level of knowledge and skills globally.

  13. Improving Earth Science Metadata: Modernizing ncISO

    Science.gov (United States)

    O'Brien, K.; Schweitzer, R.; Neufeld, D.; Burger, E. F.; Signell, R. P.; Arms, S. C.; Wilcox, K.

    2016-12-01

    ncISO is a package of tools developed at NOAA's National Center for Environmental Information (NCEI) that facilitates the generation of ISO 19115-2 metadata from NetCDF data sources. The tool currently exists in two iterations: a command line utility and a web-accessible service within the THREDDS Data Server (TDS). Several projects, including NOAA's Unified Access Framework (UAF), depend upon ncISO to generate the ISO-compliant metadata from their data holdings and use the resulting information to populate discovery tools such as NCEI's ESRI Geoportal and NOAA's data.noaa.gov CKAN system. In addition to generating ISO 19115-2 metadata, the tool calculates a rubric score based on how well the dataset follows the Attribute Conventions for Dataset Discovery (ACDD). The result of this rubric calculation, along with information about what has been included and what is missing is displayed in an HTML document generated by the ncISO software package. Recently ncISO has fallen behind in terms of supporting updates to conventions such updates to the ACDD. With the blessing of the original programmer, NOAA's UAF has been working to modernize the ncISO software base. In addition to upgrading ncISO to utilize version1.3 of the ACDD, we have been working with partners at Unidata and IOOS to unify the tool's code base. In essence, we are merging the command line capabilities into the same software that will now be used by the TDS service, allowing easier updates when conventions such as ACDD are updated in the future. In this presentation, we will discuss the work the UAF project has done to support updated conventions within ncISO, as well as describe how the updated tool is helping to improve metadata throughout the earth and ocean sciences.

  14. Complexing properties of α-iso-saccharinate: thorium

    International Nuclear Information System (INIS)

    Allard, S.; Ekberg, C.

    2005-01-01

    Full text of publication follows: In the alkaline conditions of the intended Swedish repository for long-lived, low to intermediate level waste, SFL3-5, cellulose based items will degrade with iso-saccharinate being the dominant end-product. Iso-saccharinate is a strong complexing agent for tetravalent actinides, as well as for trivalent lanthanides, and its complexation properties are of interest for the long-term repository assessment. In the presented study, the complexation of 234 Th-α-iso-saccharinate is examined using liquid-liquid- extraction and radioanalytical techniques. An organic phase consisting of 0.1 M acetylacetone in toluene was used with a 1.0 M NaClO 4 aqueous phase kept at pH 8 in a thermostated AKUFVE unit. Since the α-iso-saccharinic system consists of three species - the carboxylic α-iso-saccharinic acid, α-iso-saccharinate and α-D-iso-saccharino-1,4-lactone - care must be taken when choosing the operational pH. Keeping the aqueous phase at pH 8 results in negligible concentrations of all but the α-iso-saccharinate form while at the same time being an excellent pH for the 234 Th-acetylacetone complexation with very limited hydrolysis effect. The α- iso-saccharinate concentration was incrementally increased, and samples of equal volumes were taken from the two phases and analyzed in a liquid scintillation detector once the radioactive equilibrium between 234 Th and 234 Pa had been reached. Two complexation constants were used to fit a distribution equation to the experimental data. (authors)

  15. ISO standards on the evaluation of contamination

    International Nuclear Information System (INIS)

    Swinth, K.L.; Tamberg, T.A.

    1993-01-01

    The International Organization for Standardization (ISO) develops radiation calibration standards through Subcommittee 2 (titled ''Radiation Protection'') of Technical Committee 85 (ISO/TC85/SC2). The subcommittee has also developed standards providing guidance on the performance of measurements. ISO/TC85/SC2 consists of international technical experts who represent their countries through the international consensus process in providing guidance in several radiation protection areas. The purpose of this paper is to summarize ISO's is guidance provided in the area of contamination measurements

  16. Usability evaluation of mobile applications using ISO 9241 and ISO 25062 standards.

    Science.gov (United States)

    Moumane, Karima; Idri, Ali; Abran, Alain

    2016-01-01

    This paper presents an empirical study based on a set of measures to evaluate the usability of mobile applications running on different mobile operating systems, including Android, iOS and Symbian. The aim is to evaluate empirically a framework that we have developed on the use of the Software Quality Standard ISO 9126 in mobile environments, especially the usability characteristic. To do that, 32 users had participated in the experiment and we have used ISO 25062 and ISO 9241 standards for objective measures by working with two widely used mobile applications: Google Apps and Google Maps. The QUIS 7.0 questionnaire have been used to collect measures assessing the users' level of satisfaction when using these two mobile applications. By analyzing the results we highlighted a set of mobile usability issues that are related to the hardware as well as to the software and that need to be taken into account by designers and developers in order to improve the usability of mobile applications.

  17. [ISO 15189 medical laboratory accreditation].

    Science.gov (United States)

    Aoyagi, Tsutomu

    2004-10-01

    This International Standard, based upon ISO/IEC 17025 and ISO 9001, provides requirements for competence and quality that are particular to medical laboratories. While this International Standard is intended for use throughout the currently recognized disciplines of medical laboratory services, those working in other services and disciplines will also find it useful and appropriate. In addition, bodies engaged in the recognition of the competence of medical laboratories will be able to use this International Standard as the basis for their activities. The Japan Accreditation Board for Conformity Assessment (AB) and the Japanese Committee for Clinical Laboratory Standards (CCLS) are jointly developing the program of accreditation of medical laboratories. ISO 15189 requirements consist of two parts, one is management requirements and the other is technical requirements. The former includes the requirements of all parts of ISO 9001, moreover it includes the requirement of conformity assessment body, for example, impartiality and independence from any other party. The latter includes the requirements of laboratory competence (e.g. personnel, facility, instrument, and examination methods), moreover it requires that laboratories shall participate proficiency testing(s) and laboratories' examination results shall have traceability of measurements and implement uncertainty of measurement. Implementation of ISO 15189 will result in a significant improvement in medical laboratories management system and their technical competence. The accreditation of medical laboratory will improve medical laboratory service and be useful for patients.

  18. Intermediate species measurement during iso-butanol auto-ignition

    KAUST Repository

    Ji, Weiqi

    2015-10-01

    © 2015 The Combustion Institute.Published by Elsevier Inc. All rights reserved. This work presents the time histories of intermediate species during the auto-ignition of iso-butanol at high pressure and intermediate temperature conditions obtained using a rapid compression machine and recently developed fast sampling system. Iso-butanol ignition delays were acquired for iso-butanol/O2 mixture with an inert/O2 ratio of 7.26, equivalence ratio of 0.4, in the temperature range of 840-950 K and at pressure of 25 bar. Fast sampling and gas chromatography were used to acquire and quantify the intermediate species during the ignition delay of the same mixture at P = 25.3 bar and T = 905 K. The ignition delay times and quantitative measurements of the mole fraction time histories of methane, ethene, propene, iso-butene, iso-butyraldehyde, iso-butanol, and carbon monoxide were compared with predictions from the detailed mechanisms developed by Sarathy et al., Merchant et al., and Cai et al. It is shown that while the Sarathy mechanism well predicts the overall ignition delay time, it overpredicts ethene by a factor of 6-10, underpredicts iso-butene by a factor of 2, and overpredicts iso-butyraldehyde by a factor of 2. Reaction path and sensitivity analyses were carried out to identify the reactions responsible for the observed inadequacy. The rates of iso-butanol hydrogen atom abstraction by OH radical and the beta-scission reactions of hydroxybutyl radicals were updated based on recently published quantum calculation results. Significant improvements were achieved in predicting ignition delay at high pressures (25 and 30 bar) and the species concentrations of ethene and iso-butene. However, the updated mechanism still overpredicts iso-butyraldehyde concentrations. Also, the updated mechanism degrades the prediction in ignition delay at lower pressure (15 bar) compared to the original mechanism developed by Sarathy et al.

  19. Intermediate species measurement during iso-butanol auto-ignition

    KAUST Repository

    Ji, Weiqi; Zhang, Peng; He, Tanjin; Wang, Zhi; Tao, Ling; He, Xin; Law, Chung K.

    2015-01-01

    © 2015 The Combustion Institute.Published by Elsevier Inc. All rights reserved. This work presents the time histories of intermediate species during the auto-ignition of iso-butanol at high pressure and intermediate temperature conditions obtained using a rapid compression machine and recently developed fast sampling system. Iso-butanol ignition delays were acquired for iso-butanol/O2 mixture with an inert/O2 ratio of 7.26, equivalence ratio of 0.4, in the temperature range of 840-950 K and at pressure of 25 bar. Fast sampling and gas chromatography were used to acquire and quantify the intermediate species during the ignition delay of the same mixture at P = 25.3 bar and T = 905 K. The ignition delay times and quantitative measurements of the mole fraction time histories of methane, ethene, propene, iso-butene, iso-butyraldehyde, iso-butanol, and carbon monoxide were compared with predictions from the detailed mechanisms developed by Sarathy et al., Merchant et al., and Cai et al. It is shown that while the Sarathy mechanism well predicts the overall ignition delay time, it overpredicts ethene by a factor of 6-10, underpredicts iso-butene by a factor of 2, and overpredicts iso-butyraldehyde by a factor of 2. Reaction path and sensitivity analyses were carried out to identify the reactions responsible for the observed inadequacy. The rates of iso-butanol hydrogen atom abstraction by OH radical and the beta-scission reactions of hydroxybutyl radicals were updated based on recently published quantum calculation results. Significant improvements were achieved in predicting ignition delay at high pressures (25 and 30 bar) and the species concentrations of ethene and iso-butene. However, the updated mechanism still overpredicts iso-butyraldehyde concentrations. Also, the updated mechanism degrades the prediction in ignition delay at lower pressure (15 bar) compared to the original mechanism developed by Sarathy et al.

  20. Aplikace ISO norem v oblasti vývoje softwaru

    OpenAIRE

    Ullrich, Jan

    2007-01-01

    Thesis evaluates ISO standars used for software developement and their relationship to methodologies. It also describes processes according to international standard ISO/IEC 12207 and quality management systems according to ISO 9000. It evaluates also mothodlogy RUP and agile methodollogies. The goal of the thesis to tailor processes related to ISO 9001 to be compliant to the ISO/IEC 12207 in a small company.

  1. Peningkatan Mutu Proses Perguruan Tinggi Melalui Sistem Mutu Iso 9000

    Directory of Open Access Journals (Sweden)

    Th. Widia Soerjaningsih

    2004-09-01

    Full Text Available Article was made to answer these several questions;  what is acreditation and the application in the college; what is ISO 9000 quality system; why is ISO 9000 needed by the college; how ISO 9000 can support the achievement of the defined quality level; how ISO  9000 guarantee the achievement of BAN target including quality, efficiency, and relevance; what is the difference between BAN Acreditation and ISO 9000 Certification; ISO 9000 Consultant: why it is necessary, how to choose it, the line of the contract; ISO 9000 Assessor and the achieve certification: SGS and etc.; and ISO 9000 Certification Proccess Cost Aspect.   

  2. ISO science - observations of dusty discs.

    Science.gov (United States)

    Heske, A.

    1992-12-01

    ISO, the Infrared Space Observatory, will be an infrared observing facility in space. Via submission of observing proposals, use of this facility will be open to the astronomical community. The scientific payload consists of two spectrometers, a camera and a photo-polarimeter. Following an overview of the ISO mission, this paper describes the highlights of the Central Programme - proposals which are being prepared by the instrument groups, the mission scientists and the astronomers of the ISO Science Operations Team - with special emphasis on the proposals concerned with dusty discs.

  3. Launching the chaotic realm of iso-fractals: A short remark

    Energy Technology Data Exchange (ETDEWEB)

    O' Schmidt, Nathan [Department of Mathematics, Boise State University, 1910 University Drive, Boise, ID 83725 (United States); Katebi, Reza [Department of Physics, California State University in Fullerton, 800 North State College Boulevard, Fullerton, CA 92831 (United States); Corda, Christian [Institute for Theoretical Physics and Advanced Mathematics Einstein-Galilei (IFM), Via Santa Gonda 14, 59100 Prato (Italy)

    2015-03-10

    In this brief note, we introduce the new, emerging sub-discipline of iso-fractals by highlighting and discussing the preliminary results of recent works. First, we note the abundance of fractal, chaotic, non-linear, and self-similar structures in nature while emphasizing the importance of studying such systems because fractal geometry is the language of chaos. Second, we outline the iso-fractal generalization of the Mandelbrot set to exemplify the newly generated Mandelbrot iso-sets. Third, we present the cutting-edge notion of dynamic iso-spaces and explain how a mathematical space can be iso-topically lifted with iso-unit functions that (continuously or discretely) change; in the discrete case examples, we mention that iteratively generated sequences like Fibonacci’s numbers and (the complex moduli of) Mandelbrot’s numbers can supply a deterministic chain of iso-units to construct an ordered series of (magnified and/or de-magnified) iso-spaces that are locally iso-morphic. Fourth, we consider the initiation of iso-fractals with Inopin’s holographic ring (IHR) topology and fractional statistics for 2D and 3D iso-spaces. In total, the reviewed iso-fractal results are a significant improvement over traditional fractals because the application of Santilli’s iso-mathematics arms us an extra degree of freedom for attacking problems in chaos. Finally, we conclude by proposing some questions and ideas for future research work.

  4. Lessons learned with ISO 14001 at DOE sites

    Energy Technology Data Exchange (ETDEWEB)

    Wilkinson, C. H., LLNL

    1998-03-01

    ISO 14001 is the international standard for environmental management systems (EMS). The standard applies the `plan, do, check, act` management system model to assure that the environmental impacts of operations are fully considered in planning and facility operations. ISO 14001 has grown in popularity in both the public and the private sector and has seen increasing utility within the U.S. Department of Energy (DOE). While there is no final DOE policy or requirement for ISO 14001 EMS implementation, ISO 14001 commands an active presence at many DOE sites. In general, the impetus for ISO 14001 in the DOE complex has been either an initiative by site management contractors to improve performance, or an actual requirement in the new management contracts for the sites. Several DOE sites now are committed to implement EMS`s in conformance with ISO 14001: Brookhaven National Laboratory (BNL), Hanford, Idaho National Engineering and Environmental Laboratory (INEEL), Kansas City Plant, Nevada Test Site, Savannah River Site (SRS), Waste Isolation Pilot Project (WIPP), West Valley. Several other DOE sites are expected to proceed in the near future with an EMS consistent with ISO 14001. However, not all sites are proceeding with an ISO 14001 EMS based on individual site business considerations. This paper describes the status of EMS implementation at these sites and identifies lessons learned that may be of use to other DOE sites.

  5. The international ISOE programme. ISOE IAEA technical centre activities

    International Nuclear Information System (INIS)

    Gustafsson, M.

    1996-01-01

    The objective of the sub-programme on Occupational Radiation Protection in the International Atomic Energy Agency, IAEA, is to promote a harmonized approach to optimizing occupational radiation protection by developing guidelines for controlling radiation doses in the workplace and on current occupational radiation protection techniques. A significant part of this programme is the provision of assistance to developing member states to bring their radiation safety infrastructure to an appropriate level for the usage of radiation in the state. In consistence with these objectives the IAEA has been involved with the ISOE programme from its inception and has contributed actively to its growth. In 1993 an arrangement was agreed between the IAEA and the Nuclear Energy Agency, NEA, by which the IAEA co-sponsors ISOE inviting those IAEA member states which are not members of the NEA to participate cost-free in the programme. (author)

  6. A graded approach to ISO 9000 implementation for records managers

    Energy Technology Data Exchange (ETDEWEB)

    Pasterczyk, C.E.

    1994-08-01

    ISO 9000 is a series of quality system standards developed by Technical Committee 176 of the International Standards Organization. The series includes three standards, ISO 9001 `Quality systems--Model for quality assurance in design/development, production, installation and serving,` ISO 9002 `Quality systems--Model for quality assurance in production and installation,` ISO 9003 `Quality systems--Model for quality assurance in final inspection and test,` and two guidelines, ISO 9000 `Quality management and quality assurance standards` and ISO 9004 `Quality management and quality system elements--Guidelines.` In companies with quality programs already in place, the structure of the ISO series lends itself to augmenting those policies, procedures, and instructions where problems exist or where the risks of failure are greater. The objectives of this paper are to provide a basic familiarity to ISO 9000 and quality assurance concepts; provide a higher level of familiarity to the records management and document control portions of the ISO 9000 series; and to discuss a graded approach to meeting the intent of ISO 9000.

  7. ISO 14001

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg

    2004-01-01

    The aim of this paper is to discuss a number of issues related to ISO 14001, the international standard for environmental management systems (EMS). The standard is a process standard that leaves room for interpretation at company level as well as among lead auditors from certifying bodies...

  8. Risk in Management Systems according to ISO standard

    Directory of Open Access Journals (Sweden)

    P. Królas

    2010-07-01

    Full Text Available The purpose of this article was to present selected management standards in context of risk management. It presents main ISOmanagement standards (ISO 9001, ISO 14001, OHSAS 18001, ISO 27001, BS 25999, ISO 31000 that apply to polish enterprises. In thefirst part of this article there are analyzed management standards regarding quality, environment, occupational health and safety,information security, as well as business continuity management and risk management. The second part of the article discusses the processof dealing with risk based on chosen management standard.

  9. Implementation and Impact of ISO 9001

    NARCIS (Netherlands)

    B. Manders (Basak)

    2015-01-01

    markdownabstract__Abstract __ The ISO 9001 quality management standard has been implemented by more than one million organizations in 187 countries since its introduction in 1987. A newer version of ISO 9001 is planned to be introduced in 2015. Even though it is widely used by organizations to

  10. The new international standard ISO 14001: 2004 environmental management system

    International Nuclear Information System (INIS)

    Oheba, Jamal Basher

    2006-01-01

    ISO 14001 is one standard in the ISO 14000 series of standards developed by International Organization of Standardization (ISO). Since it was published in 19096, it has rapidly become the most important environmental standard in the world. ISO 14001 is an environmental management system (EMS) that can be classified into environmental technologies provides a systematic procedure to all kind of organizations to prevent pollutions, protect environment and to improve their overall environmental performance. This new standard ISO 14001 2004 was published on November 15, 2004. It cancels and replaced the old ISO 14001-1996. Because the important of the previous standard for our local industries, firms, ...etc, this paper presents ISO 14001 concepts, issues, benefits and focuses on the stages of implementation to achieve ISO 14001-2004 certification which includes general requirements environmental policy, planning (objectives, targets ..), implementation and operations, checking and management review ...etc and presents how to apply isotop time saver software to design records, and to save time to implement ISO 14001 2004 and finally a conclusion is provided.(Author)

  11. Application Security in the ISO27001 Environment

    CERN Document Server

    Vinod, Vasudevan; Firosh, Ummer

    2008-01-01

    Application Security in the ISO27001 Environment demonstrates how to secure software applications within a best practice ISO/IEC 27001 environment and supports implementation of the PCI DSS Payment Application Security Standard.

  12. Tietoturvallisuusauditointi ISO 27000-viitekehyksessä

    OpenAIRE

    Luoma, Ilmari

    2015-01-01

    Tiedon olemassaolo eri olomuodoissa muodostaa vaikeasti hallittavan uhkakentän, jonka käsittelyyn kansainvälisesti hyväksytty ISO 27000 -standardi on hyvä väline. Työn tarkoitus on perehtyä ISO/IEC 27000 -standardisarjaan, soveltaa standardin vaatimuksia laatimalla tietoturvallisuuden auditointiaineisto ja -menetelmä, sekä toteuttaa tietoturvallisuusauditointi käytännössä. Työssä esitellään tietoturvallisuuden kytkeytyminen yritysturvallisuuteen, tietoturvallisuuden osa-alueittainen ...

  13. PENGGABUNGAN PENERAPAN SISTEM JAMINAN MUTU ISO 9001:2008 DAN SISTEM HACCP KE DALAM SISTEM MANAJEMEN KEAMANAN PANGAN ISO 22000:2009 (STUDI KASUS DI PT INDOKOM SAMUDRA PERSADA [The Merger of Quality Assurance System ISO 9001:2008 and HACCP system into Food

    Directory of Open Access Journals (Sweden)

    Novri Ilmiawan

    2014-10-01

    Full Text Available The object of this research was to merge the application of HACCP system and ISO 9001:2008 in ISP company into ISO 22000:2009. The  research method used was case study method. The study was conducted on three stages. The first was the arrangement gap analysis conducted by comparing the conditions of the company with ISO 22000:2009 standards. The second was by observing sanitation and pre requisite programs. The third was by observing traceability system. The data in this research were reported descriptively, consisted of ISO 9001:2008 and HACCP application in the company and the gaps of principles in ISO 22000:2009 toward ISO 9001:2008 and HACCP. The result showed that ISP company has applied 12 steps which covered in HACCP system, and also the ISO 9001 system were appropriate with ISO 9001:2008 standards in every clauses. Pre requisite program (GMP and SSOP have been effectively applied. GMP in ISP company is categorized on the first spot (excellent. The eight keys of SSOP have been fulfilled. ISP company has been fulfilling 54 from 57 (94.74% criteria in ISO 22000:2009 standards, yet there still several things needed to be improved, which are the quality manual content  and HACCP table plan and its monitoring. The  traceability system has been applied well in ISP. Keywords : HACCP, ISO 9001, ISO 22000, GMP, SSOP.

  14. ADOPTION OF ISO 9001 QUALITY MANAGEMENT STANDARD IN AFRICA

    Directory of Open Access Journals (Sweden)

    Erlantz Allur

    2014-03-01

    Full Text Available This article analyzes the dissemination of ISO 9001, the main global management standards, within Africa. The work refers to the diffusion of ISO 9001 standard in terms of its certification intensity. In this article, the dissemination of ISO 9001 in Africa has been analyzed. The findings reveal that the diffusion of the standard in this continent is not very relevant, what might be seen as an indicator of the process of Africa's trade marginalization in the age of globalization. The general certification intensity of the continet is of 0.18; in other words, the proportion of the contribution of Africa to the global GDP of the world is more than five times superior to the proportion of ISO 9001 certificates located in Africa. By means of the logistic model the dissemination of ISO 9001 is forecasted, and it has been observed that the diffusion of ISO 9001 in Africa is in an 85% of its saturation point. Taking into account this model, it's expected that the dissemination of ISO 9001 will be growing until 2020.

  15. Verification the 25-kgy dose using the iso standard iso/tr 13409 for the production of bone grafts

    International Nuclear Information System (INIS)

    Otero, I.; Barrera, L.; Diaz, A.; Napoles, D.; Sanchez, E

    2001-01-01

    The purpose of this work was to verify the 25 Gy dose using the ISO standard ISO/TR 13409 for the production of bone grafts from the Tissue Bank ORTOP of the Complejo Cientifico Ortopedico Internacional Frank Pais. We performed two principal microbiological activities: bioburden estimate, pre-sterilization count plus a compensation for the efficiency of the recovery method, by ISO 11737-1 and test of sterility by ISO 11737-2. The techniques for Bioburden estimation could be direct or indirect. Choice of direct vs. indirect depends on number of contaminating micro-organisms, product configuration, ability to remove microbial contamination, effect of removal method on microbial viability, types and location of micro-organisms, nature of product and culture conditions. For a test of sterility, he product unit or SIP putted direct immersion in educated culture medium and incubate. Keep precaution to minimize level to the false positives is necessary

  16. ISO 9001 quality management systems

    CERN Document Server

    Natarajan, Dhanasekharan

    2017-01-01

    This book explains the requirements of ISO 9001 for establishing quality management system (QMS) for an organization. The requirements are illustrated with examples from industries for understanding the requirements and preparing the documents of QMS with high clarity. Methods of integrating ISO 9001 requirements with enterprise resource planning (ERP) software are presented. The software integrated approach enables process owners to focus on their core tasks of achieving the planned outputs of processes and the software generates quality records automatically.

  17. Lean principles adoption in environmental management system (EMS - ISO 14001

    Directory of Open Access Journals (Sweden)

    Perumal Puvanasvaran

    2012-12-01

    Full Text Available Purpose: The purpose of this study is to examine the characteristic of the lean principles into ISO 14001 and to propose linkage of the lean principles and ISO 14001.Design/methodology/approach: To achieve the objective of the study, literature survey and quantitative research method using questionnaires survey are used.Findings and Originality/value: The findings of this study confirm that ISO 14001 certified company adopted lean production practices.  The study also proves that lean principles have positive and significant relationship with ISO 14001 EMS and the linkage can be made between lean principles and ISO 14001 to achieve Continual Improvement.Research limitations/implications: The small sizes of the sample of the participating companies are the main limitations of this study and this research mainly focuses on the manufacturing environment and services industry.Practical implications: This research show that all ISO 14001 companies do adopt at least one lean production practices and the main findings are lean principles has positive and highly significant relationship with ISO 14001 requirements.  This is because the integration of lean principles into ISO 14001 will serve practical methods for ISO14001 EMS to achieve the continual improvement.Originality/value: This research is amongst the first to study the combined lean principles with ISO 1400.  Based on the current situation, there is no integration within this two management system. 

  18. Standardization of Image Quality Analysis – ISO 19264

    DEFF Research Database (Denmark)

    Wüller, Dietmar; Kejser, Ulla Bøgvad

    2016-01-01

    There are a variety of image quality analysis tools available for the archiving world, which are based on different test charts and analysis algorithms. ISO has formed a working group in 2012 to harmonize these approaches and create a standard way of analyzing the image quality for archiving...... systems. This has resulted in three documents that have been or are going to be published soon. ISO 19262 defines the terms used in the area of image capture to unify the language. ISO 19263 describes the workflow issues and provides detailed information on how the measurements are done. Last...... but not least ISO 19264 describes the measurements in detail and provides aims and tolerance levels for the different aspects. This paper will present the new ISO 19264 technical specification to analyze image quality based on a single capture of a multi-pattern test chart, and discuss the reasoning behind its...

  19. Twenty new ISO standards on dosimetry for radiation processing

    International Nuclear Information System (INIS)

    Farrar IV, H.

    2000-01-01

    Twenty standards on essentially all aspects of dosimetry for radiation processing were published as new ISO standards in December 1998. The standards are based on 20 standard practices and guides developed over the past 14 years by Subcommittee E10.01 of the American Society for Testing and Materials (ASTM). The transformation to ISO standards using the 'fast track' process under ISO Technical Committee 85 (ISO/TC85) commenced in 1995 and resulted in some overlap of technical information between three of the new standards and the existing ISO Standard 11137 Sterilization of health care products - Requirements for validation and routine control - Radiation sterilization. Although the technical information in these four standards was consistent, compromise wording in the scopes of the three new ISO standards to establish precedence for use were adopted. Two of the new ISO standards are specifically for food irradiation applications, but the majority apply to all forms of gamma, X-ray, and electron beam radiation processing, including dosimetry for sterilization of health care products and the radiation processing of fruit, vegetables, meats, spices, processed foods, plastics, inks, medical wastes, and paper. Most of the standards provide exact procedures for using individual dosimetry systems or for characterizing various types of irradiation facilities, but one covers the selection and calibration of dosimetry systems, and another covers the treatment of uncertainties using the new ISO Type A and Type B evaluations. Unfortunately, nine of the 20 standards just adopted by the ISO are not the most recent versions of these standards and are therefore already out of date. To help solve this problem, efforts are being made to develop procedures to coordinate the ASTM and ISO development and revision processes for these and future ASTM-originating dosimetry standards. In the meantime, an additional four dosimetry standards have recently been published by the ASTM but have

  20. A Stepwise ISO-Based TQM Implementation Approach Using ISO 9001:2015

    Directory of Open Access Journals (Sweden)

    Chen Chi-kuang

    2016-12-01

    Full Text Available The lack of an implementation roadmap always deters enterprises from choosing Total Quality Management (TQM as its major management approach. This paper proposes a stepwise ISO-based TQM implementation approach which is based on the notion of the new three-dimensional overall business excellence framework developed by Dahlgaard et al. [1]. The proposed approach consists of nine steps comprising three categories: “TQM faith building”, “TQM tools and techniques learning”, and “system development”. The steps in each of the three categories are arranged to span across the proposed nine-step approach. The ISO 9001:2015 standard is used as a case study to demonstrate the proposed approach. The ideas and benefits of the proposed approach are further discussed in relation to this illustration.

  1. New ISO standard - personnel photographic film dosemeters

    International Nuclear Information System (INIS)

    Brabec, D.

    1980-01-01

    The ISO Standard 1757 ''Personnel Photographic Film Dosemeters'', issued in June 1980, is briefly described. UVVVR's own dosemeter developed for use in the national film dosimetry service in Czechoslovakia is evaluated in relation to this ISO Standard. (author)

  2. SINERGI ISO 9001:2000 - CMMI PADA INDUSTRI PENGEMBANG PERANGKAT LUNAK

    Directory of Open Access Journals (Sweden)

    Leo Willyanto Santoso

    2005-01-01

    Full Text Available All sectors of society including softwere industry, have a big concern about quality, both of product quality and service quality. The need to manage risk, has a strong relation with quality and increases system complexity. Standarization in determining quality, ISO is a must for all software developer. If we study further, ISO 9001:2000 still has some weakness especially for implementation in software product. This paper presents a comparative analysis of quality approaches to risk management. This paper also provide a general overview of all the risks aspects treated in ISO 9001:2000 standards and CMMI model version 1.1. In this research, we obtain a strategy to implement ISO 9001:2000 and CMMI together when we make a planing to increase software process. Besides it produces analysis how to change position from ISO 9001:2000 to CMMI. In the implementation on software industry PT 'X', obtain get various benefits that has never been obtained before. Abstract in Bahasa Indonesia : Semua hal dalam hidup ini selalu memperhatikan masalah kualitas, baik itu berupa kualitas produk ataupun kualitas layanan. Pada industri perangkat lunak, hal ini tidak dibedakan, kebutuhan untuk menghasilkan produk yang berkualitas akan meningkatkan kekompleksan dari sebuah sistem. Standarisasi dalam penentuan kualitas, ISO sudah menjadi keharusan bagi para pengembang perangkat lunak. Apabila diteliti lebih lanjut, ISO 9001:2000 masih mempunyai banyak kekurangan, khususnya untuk diaplikasikan dalam produk perangkat lunak.Pada penelitian ini, akan dibahas analisis perbandingan dengan melakukan pendekatan kualitas untuk meningkatkan proses perangkat lunak dengan melakukan mapping antara ISO 9001:2000 dengan CMMI. Hal-hal yang dibahas berupa aspek-aspek dari standard ISO dan CMMI versi 1.1. Pada penelitian ini, dapat diperoleh strategi untuk menerapkan ISO 9001:2000 dan CMMI secara sinergi ketika merencanakan untuk melakukan peningkatan proses perangkat lunak. Selain itu

  3. Preliminary phytochemical screening and alpha-glucosidase inhibitory activity of Philippine taro (Colocasia esculenta (L.) Schott var. PSB-VG #9)

    Science.gov (United States)

    Lebosada, Richemae Grace R.; Librando, Ivy L.

    2017-01-01

    The study was conducted to determine the anti-hyperglycemic property in terms of α-glucosidase inhibitory activity of the various parts (corm, leaf and petiole) of Colocasia esculenta (L.) Schott var. PSB-VG #9. Each of the plant parts were extracted with 95% ethanol and concentrated using a rotary evaporator at 40 °C. The crude extracts were screened for the presence of alkaloids, flavonoids, glycosides and saponins using Thin Layer Chromatography. The α-glucosidase inhibitory activity of the crude extracts (50 mg/L) were assayed spectrophotometrically using a microplate reader. The results of the phytochemical screening revealed the presence of alkaloids, flavonoids, and saponins in the leaf part while flavonoids and saponins were detected in the petiole and only saponins were present in the corm. The assay showed that the percentage α-glucosidase inhibition of the 50 mg/L ethanolic crude extract of the corm, leaves and petiole of C. esculenta are 68.03, 71.64 and 71.39%, respectively. Statistical analysis shows significant differences in the α-glucosidase inhibition among the various plant parts. It can be concluded that the ethanolic crude extracts of the different parts of C. esculenta (L.) Schott var. PSB-VG #9 exhibited inhibitory activity against α-glucosidase and the presence of phytochemicals like alkaloids, flavonoids and saponins may have contributed greatly to the inhibitory activity of the plant extract and can be further subjected for isolation of the therapeutically active compounds with antidiabetes potency.

  4. An introduction to information security and ISO27001:2013

    CERN Document Server

    Watkins, Steve

    2013-01-01

    Up to date with the latest version of the Standard (ISO27001:2013), An Introduction to information security and ISO27001:2013 is the perfect solution for anyone wanting an accurate, fast, easy-to-read primer on information security from an acknowledged expert on ISO27001.

  5. Information security risk management for ISO27001/ISO27002

    CERN Document Server

    Calder, A; Watkins, S

    2010-01-01

    Drawing on international best practice, including ISO/IEC 27005, NIST SP800-30 and BS7799-3, the book explains in practical detail how to carry out an information security risk assessment. It covers key topics, such as risk scales, threats and vulnerabilities, selection of controls, and roles and responsibilities, and includes advice on choosing risk assessment software.

  6. ISO 9001 2000 : the quality management process

    CERN Document Server

    Tricker, Ray

    2006-01-01

    With the publication of ISO 9001:2000, there is now a single quality management ?requirements? standard that is applicable to all organisations, products and services. ISO 9001:2000 is the only standard that can be used for the certification of a QMS and its generic requirements can be used by any organisation.ISO 9001:2000 applies to all types or organisations. It is the quality standard which specifies the requirements of quality management systems for use where organisations need to demonstrate their capability to provide products and services which meet both customer needs and relevant reg

  7. [ISO 9001:2015 Certification in Quality Management].

    Science.gov (United States)

    Enders, Christian; Lang, Gabriele E; Lang, Gerhard K; Werner, Jens Ulrich

    2017-07-01

    Quality management improves the structures, processes and results of organizations of all kinds. Many practices and clinics have their existing quality management system certified according to ISO 9001, (e.g., to check their own quality management system or to obtain a testimonial against third parties). The latest version ISO 9001:2015 contains some changes, both structurally and in terms of content. These changes can be met with reasonable efforts. An ISO 9001:2015 certification represents a value for your organization, but these advantages are often not directly measurable. Georg Thieme Verlag KG Stuttgart · New York.

  8. ISO 9001 and ISO 14001: An Integrated Quality Management System for an MTR Facility SAFARI-1 Research Reactor

    International Nuclear Information System (INIS)

    Du Bruyn, J.F.; Piani, C.S.B.

    2005-01-01

    The SAFARI-1 research reactor, owned and operated by the South African Nuclear Energy Corporation (Necsa), initially obtained ISO 9001 accreditation of its Quality, Health, Safety and Environmental (QHSE) management system via international affiliation from the South African Bureau of Standards (SABS) during 1998 and re-certification according to ISO 9001 (2000) in 2003. With ever-increasing demands on nuclear facilities to demonstrate conformance to environmental policies, SAFARI-1 has now developed an Environmental Management System (EMS) that is compliant with ISO 14001 (1996) and is fully integrated with the SAFARI-1 Quality Management System (QMS). The dynamic involvement of SAFARI-1 in commercial applications demanded that any transition of the original QMS to a fully incorporated QHSE system had to be done in a way that would ensure sustained delivery of a safe and reliable service with continuous quality. At the same time, the primary vision of operating a facility under an efficient financial management programme was essential. The criteria established by the original ISO 9001 compliant QMS were appraised against the additional requirements of ISO 14001 and a suitable superstructure derived for generation and implementation of an inclusive EMS. The transitional integration of this system was planned so as to produce a QMS suitable to quality, environmental and other management related issues for application to the unique function of a nuclear research reactor. (author)

  9. Sertifikatõ ISO - mafioznaja struktura so znakom pljuss / Olesja Bõkova

    Index Scriptorium Estoniae

    Bõkova, Olesja

    2005-01-01

    Esimesed ISO sertifikaadid, mille aluseks on briti kvaliteedi standardite süsteem, anti Euroopa Liidus välja 1987. a. ISO sertifikaadid Eestis. Diagramm: Välja antud ISO 9000 sertifikaadid 1994-2004

  10. Metrological management evaluation based on ISO10012: an empirical study in ISO-14001-certified Spanish companies

    International Nuclear Information System (INIS)

    Beltran, Jaime; Rivas, Miguel; Munuzuri, Jesus; Gonzalez, Cristina

    2010-01-01

    Environmental management systems based on the ISO 14001 standard rely strongly on metrological measurement and confirmation processes to certify the extent to which organizations monitor and improve their environmental behavior. Nevertheless, the literature lacks in studies that assess the influence of these metrological processes on the performance of environmental management in organizations, even now that the international standard ISO 10012 is already available to establish requisites and guidelines for the development of a metrological management system that is compatible with any other standardized management system. This work seeks to assess that influence through the development of an evaluation model for metrological management, which is then validated through an experimental analysis of the results obtained from the application of an audit process in 11 Spanish companies, all ISO-14001-certified and operating in different industrial sectors. (author)

  11. Significance of ISO 9000 Quality Management System for ...

    African Journals Online (AJOL)

    Significance of ISO 9000 Quality Management System for Performance ... of ISO 9000 Quality Management System implementation for performance improvement. ... to find out the relationship between certification and process variability.

  12. Neuroprotective effects of α-iso-cubebenol on glutamate-induced neurotoxicity.

    Science.gov (United States)

    Park, Sun Young; Choi, Yung Hyun; Park, Geuntae; Choi, Young-Whan

    2015-09-01

    α-Iso-cubebenol is a natural compound isolated from Schisandra chinensis, and is reported to have beneficial bioactivity including anti-inflammatory and anti-tumor activities. Glutamate-induced oxidative neuronal damage has been implicated in a variety of neurodegenerative disorders. Here we investigated the mechanisms of α-iso-cubebenol protection of mouse hippocampus-derived neuronal cells (HT22 cells) from apoptotic cell death induced by the major excitatory neurotransmitter, glutamate. Pretreatment with α-iso-cubebenol markedly attenuated glutamate-induced loss of cell viability and release of lactate dehydrogenase), in a dose-dependent manner. α-Iso-cubebenol significantly reduced glutamate-induced intracellular reactive oxygen species and calcium accumulation. Strikingly, α-iso-cubebenol inhibited glutamate-induced mitochondrial depolarization, which releases apoptosis-inducing factor from mitochondria. α-Iso-cubebenol also suppressed glutamate-induced phosphorylation of extracellular-signal-regulated kinases. Furthermore, α-iso-cubebenol induced CREB phosphorylation and Nrf-2 nuclear accumulation and increased the promoter activity of ARE and CREB in HT22 cells. α-Iso-cubebenol also upregulated the expression of phase-II detoxifying/antioxidant enzymes such as HO-1 and NQO1. Subsequent studies revealed that the inhibitory effects of α-iso-cubebenol on glutamate-induced apoptosis were abolished by small interfering RNA-mediated knockdown of CREB and Nrf-2. These findings suggest that α-iso-cubebenol prevents excitotoxin-induced oxidative damage to neurons by inhibiting apoptotic cell death, and might be a potential preventive or therapeutic agent for neurodegenerative disorders. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. SISTEM HACCP KE DALAM SISTEM MANAJEMEN KEAMANAN PANGAN ISO 22000:2009 (STUDI KASUS DI PT INDOKOM SAMUDRA PERSADA [The Merger of Quality Assurance System ISO 9001:2008 and HACCP system into Food Safety Management SystemISO 22000:2009 (Case Study at Indoko

    Directory of Open Access Journals (Sweden)

    Novri Ilmiawan

    2014-12-01

    Full Text Available The object of this research was to merge the application of HACCP system and ISO 9001:2008 in ISP company into ISO 22000:2009. The  research method used was case study method. The study was conducted on three stages. The first was the arrangement gap analysis conducted by comparing the conditions of the company with ISO 22000:2009 standards. The second was by observing sanitation and pre requisite programs. The third was by observing traceability system. The data in this research were reported descriptively, consisted of ISO 9001:2008 and HACCP application in the company and the gaps of principles in ISO 22000:2009 toward ISO 9001:2008 and HACCP. The result showed that ISP company has applied 12 steps which covered in HACCP system, and also the ISO 9001 system were appropriate with ISO 9001:2008 standards in every clauses. Pre requisite program (GMP and SSOP have been effectively applied. GMP in ISP company is categorized on the first spot (excellent. The eight keys of SSOP have been fulfilled. ISP company has been fulfilling 54 from 57 (94.74% criteria in ISO 22000:2009 standards, yet there still several things needed to be improved, which are the quality manual content  and HACCP table plan and its monitoring. The  traceability system has been applied well in ISP .   Key words : HACCP, ISO 9001, ISO 22000, GMP, SSOP.

  14. [Accreditation of clinical laboratories based on ISO standards].

    Science.gov (United States)

    Kawai, Tadashi

    2004-11-01

    International Organization for Standardization (ISO) have published two international standards (IS) to be used for accreditation of clinical laboratories; ISO/IEC 17025:1999 and ISO 15189:2003. Any laboratory accreditation body must satisfy the requirements stated in ISO/IEC Guide 58. In order to maintain the quality of the laboratory accreditation bodies worldwide, the International Laboratory Accreditation Cooperation (ILAC) has established the mutual recognition arrangement (MRA). In Japan, the International Accreditation Japan (IAJapan) and the Japan Accreditation Board for Conformity Assessment (JAB) are the members of the ILAC/MRA group. In 2003, the Japanese Committee for Clinical Laboratory Standards (JCCLS) and the JAB have established the Development Committee of Clinical Laboratory Accreditation Program (CLAP), in order to establish the CLAP, probably starting in 2005.

  15. Environmental Management System ISO 14001

    CERN Document Server

    Haider, Syed

    2010-01-01

    This is a must-have tool for any company in the process of adopting and incorporating the ISO 14001:2004 requirements, this book and accompanying CD-ROM provides the latest updates and amendments and translates the ISO language into actionable strategy. Offering administrative solutions to managers of all sorts, it includes practical examples of policies with objectives, targets, and action plans applicable to any process related industry or an ordinary organization. With template formats and hands-on flow charts to describe step-by-step system development, documentation, and implementation ph

  16. Synthesis and Biological Activity of 2',3'-iso-Aryl-abscisic Acid Analogs.

    Science.gov (United States)

    Wan, Chuan; Wang, Mingan; Yang, Dongyan; Han, Xiaoqiang; Che, Chuanliang; Ding, Shanshan; Xiao, Yumei; Qin, Zhaohai

    2017-12-15

    2',3'- iso -Benzoabscisic acid ( iso -PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and replacing the ring with heterocycles. Thus, 16 novel analogs of iso -PhABA were synthesized and screened with three bioassays, Arabidopsis and lettuce seed germination and rice seedling elongation. Some of them, i.e., 2',3'- iso -pyridoabscisic acid ( iso -PyABA) and 2',3'- iso -franoabscisic acid ( iso -FrABA), displayed good bioactivities that closed to iso -PhABA and natural (+)-ABA. Some others, for instance, substituted- iso -PhABA, exhibited certain selectivity to different physiological process when compared to iso -PhABA or (+)-ABA. These analogs not only provided new candidates of ABA-like synthetic plant growth regulators (PGRs) for practical application, but also new potential selective agonist/antagonist for probing the specific function of ABA receptors.

  17. Information security in accordance with ISO/IEC 27000

    OpenAIRE

    Košćak , Damjan

    2011-01-01

    The diploma assignment discusses Information Technology Security according to standards ISO/IEC 27001 and ISO/IEC 27002. Diploma consists of two parts. In the first part of the diploma a theoretical bases of information security are presented. The second part presents the introduction of ISO/IEC 27001 security standard in the company »X« in wich I performed a practical training. In the closure my diploma work is upgraded with results of my research work and their analysis as well as wit...

  18. ISO sertifikaat kuulutab tootja mainet üle maailma / Ain Alvela

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti 12. apr. lk. 24-25. ISO standardi rakendamine tagab toodangu kvaliteedi ja annab firmale usaldusväärsuse. Kommenteerib Ain Noormägi. Vt. samas: ISO 9001; ISO 14 001; Universaalne standard kohandub ettevõtte vajadustega

  19. Manufacturing of environment friendly biolubricants from vegetable oils

    Directory of Open Access Journals (Sweden)

    Ebtisam K. Heikal

    2017-03-01

    Full Text Available Environment friendly products such as fuels and lubricants are among the candidates which are studied in several countries including Egypt. The purpose of this work was to utilize commercially available palm oil and Jatropha oil for the production of biolubricants, through two stages of Transesterification. The first stage is the process of using methanol in the presence of potassium hydroxide to produce biodiesel. The second stage is the reaction of biodiesel with trimethylolpropane using sodium methoxide as catalyst to yield palm or Jatropha oil base trimethylolpropane esters (biolubricants. Palm oil based trimethylolpropane esters with yield of 97.8% was obtained after 4 h of reaction at 130 °C. Under similar reaction conditions, Jatropha oil based trimethylolpropane esters with a yield of 98.2% was obtained. The resulting products were confirmed by FTIR and evaluated by ASTM analyses. The obtained Jatropha oil based trimethylolpropane esters exhibited high viscosity indices (140, low pour point temperature (−3 °C, and moderate thermal stabilities and met the requirement of commercial industrial oil ISO VG46 grade. In spite of the high pour point of Palm oil based trimethylolpropane esters (5 °C, which needs pour point depressant to reduce the pour point, other lubrication properties such as viscosity, viscosity indices and flash point are comparable to commercial industrial oil ISO VG32 and VG46.

  20. Antioxidant mechanisms of iso-6-cassine in suppressing seizures induced by pilocarpine

    Directory of Open Access Journals (Sweden)

    Rivelilson Mendes de Freitas

    2011-06-01

    Full Text Available The aim of this study was to evaluate the in vitro antioxidant effects of 12-[(2R,5R,6R-5-hydroxy-6-methylpiperidin-2-yl]dodecan-2-one (iso-6-cassine; ISO and the anticonvulsant effects of ISO on pilocarpine-induced seizures in rats. Wistar rats were treated with 0.9% saline (i.p., control group, pilocarpine (400 mg/kg, i.p., pilocarpine group, and the association of ISO (1.0 mg/kg, i.p. plus pilocarpine (400 mg/kg, i.p., 30 min after administration of ISO (ISO plus pilocarpine group. After the treatments all groups were observed for 1h. The antioxidant effect of ISO on the pilocarpine model was assessed by determining the activity of glutathione peroxidase (GPx, glutathione-S-transferase (GST and catalase (CAT as well as the levels of reactive species (RS and lipid peroxidation (LP. In vitro, ISO (5 μM reduced RS and LP. ISO (1.0 mg/kg and abolished seizures and death induced by pilocarpine in rats. ISO protected against the increase in the RS and LP levels, GST activity as well as the inhibition of GPx activity caused by pilocarpine. In addition, ISO increased the catalase activity in hippocampus of seized rats. In conclusion, the dta suggest that ISO can present anticonvulsant and antioxidant properties in the pilocarpine model of seizures in rats.

  1. ISO developments in the United States

    International Nuclear Information System (INIS)

    Hogan, William W.

    1998-01-01

    An important feature of the restructuring process in the United States is the creation of independent system operators (ISOs) to coordinate dispatch and access to transmission grids. A number of ISOs have been proposed and are summarized here. Perhaps the greatest challenge is the pricing of transmission to give proper economic signals to market participants, and the locational pricing scheme now operating in the PJM system offers the best hope for efficient pricing. (author)

  2. ISO 9001 in a neonatal intensive care unit (NICU).

    Science.gov (United States)

    Vitner, Gad; Nadir, Erez; Feldman, Michael; Yurman, Shmuel

    2011-01-01

    The aim of this paper is to present the process for approving and certifying a neonatal intensive care unit to ISO 9001 standards. The process started with the department head's decision to improve services quality before deciding to achieve ISO 9001 certification. Department processes were mapped and quality management mechanisms were developed. Process control and performance measurements were defined and implemented to monitor the daily work. A service satisfaction review was conducted to get feedback from families. In total, 28 processes and related work instructions were defined. Process yields showed service improvements. Family satisfaction improved. The paper is based on preparing only one neonatal intensive care unit to the ISO 9001 standard. The case study should act as an incentive for hospital managers aiming to improve service quality based on the ISO 9001 standard. ISO 9001 is becoming a recommended tool to improve clinical service quality.

  3. Exploratory Research of ISO 14001:2015 Transition among Portuguese Organizations

    Directory of Open Access Journals (Sweden)

    Luis Miguel Fonseca

    2018-03-01

    Full Text Available The purpose of this paper is the assessment of the ISO 14001:2015 transition process among Portuguese ISO 14001 certified organizations, including those that successfully have already achieved ISO 14001:2015 certification. A considerable number of the surveyed companies proceeded with the transition to the ISO 14001:2015 by introducing slight adjustments and were supported by external consultants. Nearly all of the respondent companies (97% intend to transition until 15th September 2018. The highest ranked reported benefit is the “integrated approach with other management sub-systems” with a well-consolidated perception from the surveyed companies. This is aligned with the ISO 14001:2015 goal of improving the compatibility of management standards supported on the Annex SL. “Alignment with business strategy”, “improved top management commitment” and “improved internal and external communication” are also perceived to obtain significant benefits from ISO 14001:2015. The statistical tests carried out (Kruskal–Wallis confirmed that the perception of some achieved ISO 14001:2015 certification benefits is dependent on the size of the organization. Concerning the motivations to proceed with certification, results suggest that there is not a particular company profile that is compelled to certify their EMS based on a specific type of motivation (Internal or External. Due to ISO 14001:2015 novelty, these exploratory results should be subjected to additional research confirmation.

  4. Boiling Patterns of Iso-asymmetric Nuclear Matter

    International Nuclear Information System (INIS)

    Tõke, Jan

    2013-01-01

    Limits of thermodynamic metastability of self-bound neutron-rich nuclear matter are explored within the framework of microcanonical thermodynamics of interacting Fermi Gas model in Thomas-Fermi approximation. It is found that as the excitation energy per nucleon of the system is increased beyond a certain limiting value, the system loses metastability and becomes unstable with respect to joint fluctuations in excitation energy per nucleon and in isospin per nucleon. As a result, part of the system is forced to boil off in a form of iso-rich non-equilibrated vapors. Left behind in such a process, identifiable with distillation, is a more iso-symmetric metastable residue at a temperature characteristic of its residual isospin content. With a progressing increase in the initial excitation energy per nucleon, more neutron-rich matter is boiled off and a more iso-symmetric residue is left behind with progressively increasing characteristic temperature. Eventually, when all excess neutrons are shed, the system boils uniformly with a further supply of excitation energy, leaving behind a smaller and smaller residue at a characteristic boiling-point temperature of iso-symmetric matter.

  5. PRAPI: post-transcriptional regulation analysis pipeline for Iso-Seq.

    Science.gov (United States)

    Gao, Yubang; Wang, Huiyuan; Zhang, Hangxiao; Wang, Yongsheng; Chen, Jinfeng; Gu, Lianfeng

    2018-05-01

    The single-molecule real-time (SMRT) isoform sequencing (Iso-Seq) based on Pacific Bioscience (PacBio) platform has received increasing attention for its ability to explore full-length isoforms. Thus, comprehensive tools for Iso-Seq bioinformatics analysis are extremely useful. Here, we present a one-stop solution for Iso-Seq analysis, called PRAPI to analyze alternative transcription initiation (ATI), alternative splicing (AS), alternative cleavage and polyadenylation (APA), natural antisense transcripts (NAT), and circular RNAs (circRNAs) comprehensively. PRAPI is capable of combining Iso-Seq full-length isoforms with short read data, such as RNA-Seq or polyadenylation site sequencing (PAS-seq) for differential expression analysis of NAT, AS, APA and circRNAs. Furthermore, PRAPI can annotate new genes and correct mis-annotated genes when gene annotation is available. Finally, PRAPI generates high-quality vector graphics to visualize and highlight the Iso-Seq results. The Dockerfile of PRAPI is available at http://www.bioinfor.org/tool/PRAPI. lfgu@fafu.edu.cn.

  6. ISO's analysis of Comet Hale-Bopp

    Science.gov (United States)

    1997-03-01

    The European Space Agency's Infrared Space Observatory ISO inspected Comet Hall-Bopp during the spring and autumn of 1996. The need to keep ISO's telescope extremely cold restricts the spacecraft's pointing in relation to the Sun and the Earth and it ruled out observations at other times. The analyses of the 1996 observations are not yet complete, but already they give new insight into the nature of comets. Comet Hale-Bopp is believed to be a large comet with a nucleus up to 40 kilometres wide. It was discovered in July 1995 by two American astronomers working independently, Alan Hale and Thomas Bopp. At that time, the comet was a billion kilometres away from the Sun, but 200 times brighter than Halley's Comet was, when at a comparable distance. Comet Hale-Bopp will make its closest approach to the Earth on 22 March, and its closest approach to the Sun (perihelion) on 1 April 1997. Some scientific results from ISO The discovery of Comet Hale-Bopp occurred before ISO's launch in November 1995. When first observed by ISO in March and April 1996, the comet was still 700 million kilometres from the Sun, and almost as far from the Earth and ISO. With its privileged view of infrared wavebands inaccessible from the Earth's surface, ISO's photometer ISOPHOT discovered that carbon dioxide was an important constituent of the comet's emissions of vapour.ISOPHOT measured the temperature of the dust cloud around Comet Hale-Bopp. In March 1996, when the comet was still more than 700 million kilometres from the Sun, the dust cloud was at minus 120 degrees C. When ISOPHOT made similar observations in October 1996, the comet was 420 million kilometres from the Sun, and the dust cloud had warmed to about minus 50 degrees C. Intensive observations of Comet Hale-Bopp were also made by ISO's Short-Wave Spectrometer SWS, the Long-Wave Spectrometer LWS, and the ISOPHOT spectrometer PHOT-S. Results are due for publication at the end of March. They will give details about the composition

  7. CNEN, IAEA and ISO normative requirements for measurement management

    International Nuclear Information System (INIS)

    Kibrit, Eduardo

    2009-01-01

    International standard ISO 10012:2003 establishes requirements for measurement management systems, including requirements for measurement processes and measuring equipment. ISO 9001:2008 presents requirements for quality management systems, including requirements for the control of monitoring and measuring equipment. ISO 17025:2005 presents general requirements for the competence of testing and calibration laboratories. In the nuclear field the requirements for measurement management are established by standards published by the International Atomic Energy Agency (IAEA), and in Brazil, by the National Nuclear Energy Commission (CNEN). The present paper presents and discusses the normative requirements for measurement management, considering requirements established by National Nuclear Energy Commission (CNEN), International Atomic Energy Agency (IAEA), and International Organisation for Standardisation (ISO). (author)

  8. Die bestuur en opleiding van SABS ISO 9000 reeks

    OpenAIRE

    2014-01-01

    With the lifting of sanctions, South African businesses are faced with a new challenge to compete against their international counterparts on the international and domestic markets. Competing on the international markets is dependant on conforming to a recognised quality management system standard such as ISO 9000 (ISO International Standards Organisation). The South African equivalent for this standard is SABS ISO 9000. (SABS - South African Bureau of Standards). It is thus important for Sou...

  9. Application of ISO 9001:2000 in a Nuclear Medicine Department

    International Nuclear Information System (INIS)

    Rayo, J.I.; Serrano, J.; Martin, R.; Corral, C.

    2002-01-01

    Since 1947 ISO has been developing voluntary technical standards over almost all sectors of business, industry, and technology. The ISO 9000 standards were published in 1987, and new versions of the standards saw daylight in 1994 and 2000. The highlights of ISO 9001:2000 are: quality management system, management responsibility, resource management, product realization and measurement, analysis and improvement. Aim: Application of ISO 9001:2000 to a Nuclear Medicine Department for provides the organization with a model to follow, customer focus, people will understand the goals of the organization and are motivated to work for objectives and lower costs and shorter cycle times through effective use of resources. Conclusion: ISO 9001:2000 focuses on continual improvement of business processes that should be a permanent objective of the Nuclear Medicine Department

  10. Gloss uniformity measurement update for ISO/IEC 19751

    Science.gov (United States)

    Ng, Yee S.; Cui, Chengwu; Kuo, Chunghui; Maggard, Eric; Mashtare, Dale; Morris, Peter

    2005-01-01

    To address the standardization issues of perceptually based image quality for printing systems, ISO/IEC JTC1/SC28, the standardization committee for office equipment chartered the W1.1 project with the responsibility of drafting a proposal for an international standard for the evaluation of printed image quality1. An ISO draft Standard2, ISO/WD 19751-1, Office Equipment - Appearance-based image quality standards for printers - Part 1: Overview, Procedure and Common Methods, 2004 describes the overview of this multi-part appearance-based image quality standard. One of the ISO 19751 multi-part Standard"s tasks is to address the appearance-based gloss and gloss uniformity issues (in ISO 19751-2). This paper summarizes the current status and technical progress since the last two updates3, 4. In particular, we will be discussion our attempt to include 75 degree gloss (G75) objective measurement5 in differential gloss and within-page gloss uniformity. The result for a round-robin experiment involving objective measurement of differential gloss using G60 and G75 gloss measurement geometry is described. The results for two perceptual-based round-robin experiments relating to haze effect on the perception of gloss, and gloss artifacts (gloss streaks/bands, gloss graininess/mottle) are discussed.

  11. The Relationship between the Training Function and ISO-9000 Registration.

    Science.gov (United States)

    Maxwell, Randy C.; Jost, Karen L.

    ISO 9000 is one of a series of international standards providing guidelines and governing quality of products and services. The ISO 9000 certification demonstrates the capability of a supplier to control the processes that determine the acceptability of the product or service being supplied. This paper focuses on the training aspects of ISO 9000…

  12. API and ISO standards can be combined

    International Nuclear Information System (INIS)

    Weightman, R.T.; Warnack, M.F.

    1992-01-01

    This paper reports that oil field equipment and product manufacturers can maintain a competitive advantage and minimize costs by integrating American Petroleum Institute (API) licensing programs with International Standards Organization (ISO) 9001 standards under one quality system. A combined quality system approach can position a company for quality system certification under ISO 9001 while maintaining API specifications. Furthermore, only one quality system manual is needed for API licensing and ISO certification, avoiding duplication of effort. The benefits of a documented quality program include the flowing: Job descriptions and personnel qualification requirements are documented; The improved documentation allows direct tracing of specific production activities; Laboratory test methods and calibration of test equipment follow accepted standards for more reliable and reproducible test data; Quality control becomes proactive, not reactive, through internal process controls previously not implemented; Employee attitudes improve through appreciation for the overall goals of the company; Ambiguous quality issues, such as documenting special customer requirements, are easily resolved; and The company image improves with customers, particularly for those that require API Specification Q1 or ISO 9001 compliance or those having their own quality performance standards

  13. Experience with ISO quality control in assisted reproductive technology.

    Science.gov (United States)

    Alper, Michael M

    2013-12-01

    Assisted reproductive technology (ART) programs are complex organizations requiring the integration of multiple disciplines. ISO 9001:2008 is a quality management system that is readily adaptable to an ART program. The value that ISO brings to the entire organization includes control of documents, clear delineation of responsibilities of staff members, documentation of the numerous processes and procedures, improvement in tracking and reducing errors, and overall better control of systems. A quality ART program sets quality objectives and monitors their progress. ISO provides a sense of transparency within the organization and clearer understanding of how service is provided to patients. Most importantly, ISO provides the framework to allow for continual improvement. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  14. Effect of titanium and stainless steel posts in detection of vertical root fractures using NEWTOM VG cone beam computed tomography system

    International Nuclear Information System (INIS)

    Mohammadpour, Mahdis; Bakhshalian, Neema; Shahab, Shahriar; Sadeghi, Shaya; Ataee, Mona; Sarikhani, Soodeh

    2014-01-01

    Vertical root fracture (VRF) is a common complication in endodontically treated teeth. Considering the poor prognosis of VRF, a reliable and valid detection method is necessary. Cone beam computed tomography (CBCT) has been reported to be a reliable tool for the detection of VRF; however, the presence of metallic intracanal posts can decrease the diagnostic values of CBCT systems. This study evaluated and compared the effects of intracanal stainless steel or titanium posts on the sensitivity, specificity, and accuracy of VRF detection using a NewTom VG CBCT system. Eighty extracted single-rooted teeth were selected and sectioned at the cemento-enamel junction. The roots were divided into two groups of 40. Root fracture was induced in the test group by using an Instron machine, while the control group was kept intact. Roots were randomly embedded in acrylic blocks and radiographed with the NewTom VG, both with titanium and stainless steel posts and also without posts. Sensitivity, specificity, and accuracy values were calculated as compared to the gold standard. The sensitivity, specificity, and accuracy of VRF diagnosis were significantly lower in teeth with stainless steel and titanium posts than in those without posts. Interobserver agreement was the highest in teeth without posts, followed by stainless steel posts, and then titanium posts. Intracanal posts significantly decreased the VRF diagnostic values of CBCT. The stainless steel posts decreased the diagnostic values more than the titanium posts.

  15. Effect of titanium and stainless steel posts in detection of vertical root fractures using NEWTOM VG cone beam computed tomography system

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadpour, Mahdis [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Qazvin University of Medical Sciences, Qazvin (Iran, Islamic Republic of); Bakhshalian, Neema [Dept. of Advanced Periodontology, Ostrow School of Dentistry, University of Southern California, Los Angeles (United States); Shahab, Shahriar [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Shahed University, Tehran (Iran, Islamic Republic of); Sadeghi, Shaya; Ataee, Mona [Radmehr Oral and Maxillofacial Radiology Clinic, Ghazvin (Iran, Islamic Republic of); Sarikhani, Soodeh [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, University of Golestan, Gorgan (Iran, Islamic Republic of)

    2014-06-15

    Vertical root fracture (VRF) is a common complication in endodontically treated teeth. Considering the poor prognosis of VRF, a reliable and valid detection method is necessary. Cone beam computed tomography (CBCT) has been reported to be a reliable tool for the detection of VRF; however, the presence of metallic intracanal posts can decrease the diagnostic values of CBCT systems. This study evaluated and compared the effects of intracanal stainless steel or titanium posts on the sensitivity, specificity, and accuracy of VRF detection using a NewTom VG CBCT system. Eighty extracted single-rooted teeth were selected and sectioned at the cemento-enamel junction. The roots were divided into two groups of 40. Root fracture was induced in the test group by using an Instron machine, while the control group was kept intact. Roots were randomly embedded in acrylic blocks and radiographed with the NewTom VG, both with titanium and stainless steel posts and also without posts. Sensitivity, specificity, and accuracy values were calculated as compared to the gold standard. The sensitivity, specificity, and accuracy of VRF diagnosis were significantly lower in teeth with stainless steel and titanium posts than in those without posts. Interobserver agreement was the highest in teeth without posts, followed by stainless steel posts, and then titanium posts. Intracanal posts significantly decreased the VRF diagnostic values of CBCT. The stainless steel posts decreased the diagnostic values more than the titanium posts.

  16. Third statutory ordinance for assignment of competence for environmental radioactivity measuring and evaluation under the German Preventive Radiation Protection Act (StrSchVG). As of 16 October 1997

    International Nuclear Information System (INIS)

    1997-01-01

    The German Bundesamt fuer Strahlenschutz (Radiation Protection Office) is assigned the competence to perform the necessary activities for measurement and large-area monitoring of ambient gamma dose rates on behalf of the Federal Government in compliance with the German Preventive Radiation Protection Act (StrSchVG). (orig./CB) [de

  17. On the composition of ISO 25964 hierarchical relations (BTG, BTP, BTI)

    NARCIS (Netherlands)

    Alexiev, A; Isaac, A.H.J.C.A.; Lindenthal, J

    2015-01-01

    Knowledge organization systems (KOS) can use different types of hierarchical relations: broader generic (BTG), broader partitive (BTP), and broader instantial (BTI). The latest ISO standard on thesauri (ISO 25964) has formalized these relations in a corresponding OWL ontology (De Smedt et al., ISO

  18. ISO 14000 information platform. Quarterly report, January 1--March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    GETE, through its ISO 14000 Information Platform, globeNet{trademark} (www.iso14000.net), seeks to provide FETC and the US Department of Energy (DOE) with a timely, accurate, and reliable information resource on the issue of environmental management standards. This resource allows FETC to keep track of the latest developments in the ISO 14000 arena, in DOE as well as throughout the federal complex and industry. Utilizing this information, FETC and DOE can make critical decisions on their own use and implementation of the ISO 14000 standards. The information platform also provides FETC with a forum to present information on its activities, such as the DOE ISO 14000 Pilot Projects, and as an information gathering and dissemination resource for its publications. GETE works with an array of national and international contacts and content sources to gather information and provide daily updates on ISO 14000 and related environmental management issues.

  19. ISO 9001 certification for hospitals in Bulgaria: does it help service?

    Science.gov (United States)

    Stoimenova, Assena; Stoilova, Ani; Petrova, Guenka

    2014-03-04

    The aim of our study is to review the published literature on establishment and implementation of ISO 9001 QMS in European hospitals, to study the availability of International Organization for Standardization (ISO) quality management systems (QMS) in Bulgarian hospitals and to outline the main advantages of ISO implementation in the hospitals in Bulgaria. The information on availability of ISO QMS in the hospitals in Bulgaria was gathered via Bulgarian certification register, the registries of various quality associations, websites of hospitals and certification companies presented in Bulgaria. A total number of 312 hospitals in Bulgaria were screened for the availability of QMS certified against the ISO 9001 requirements. The experience of European hospitals that implemented QMS is positive and the used approaches to improve the processes and the demonstrated effects from ISO implementation are analysed by the researchers. Unlike other European Union member states, the establishment of quality management systems in Bulgaria is not compulsory. However, our study revealed that 14.42% of the hospitals in Bulgaria have implemented and have certified quality systems against the requirements of ISO 9001. Our study confirmed that a quality management system using the ISO 9001 standard is useful for the hospitals as it can help to increase the operational efficiencies, to reduce errors, improve patient safety and produce a more preventive approach instead of a reactive environment.

  20. Inter ISO Market Coordination by Calculating Border Locational Marginal Prices

    Directory of Open Access Journals (Sweden)

    BABIC, A. B.

    2013-05-01

    Full Text Available In this paper the methodology for solving Locational Marginal Price (LMP differences (inconsistency of LMPs that arise at the boundary buses between separate power markets is proposed. The algorithm developed enables us to obtain consistent LMP values at the boundary buses between interconnected ISOs. A Primal-Dual Interior Point based optimal power flow (OPF is applied, with complete set of power system physical limit constraints, to solve a regional spot market. The OPF is implemented such that producer and consumer behaviors are modeled simultaneously, while the welfare is maximized. In this paper a generalized methodology for multiple ISOs case is proposed and later it is practically applied on two interconnected independent entities. The algorithm for approximation of cost coefficients of generators and dispatchable loads for neighboring ISOs is proposed. The developed algorithm enables participating ISOs to obtain LMPs at the boundary buses with other interconnected ISOs. By controlling interchange of electric power at the scheduled level, regional spot markets are resolved eliminating possible exercise of market power by individual interconnected ISOs. Results of proposed methodology are tested on the IEEE 118-bus power system.

  1. The dark side of ISO 14001: The symbolic environmental behavior

    Directory of Open Access Journals (Sweden)

    Vera Ferrón Vílchez

    2017-01-01

    Full Text Available Some of the academic research on ISO 14001 has focused on analyzing the benefits of its adoption. However, this international standard has also received some criticism, particularly in respect of the adoption of ISO 14001 when not accompanied by significant improvements in environmental performance. This study analyzes the relationship between the symbolic environmental behavior and the adoption of ISO 14001. In so doing, it uses binary logistic regression to analyze an international sample of 1961 manufacturing facilities that each employs more than 50 people. The results indicate that the higher the symbolic environmental performance of the firm, the greater the probability of adopting ISO 14001.

  2. ISO certification pays off in quality improvement

    International Nuclear Information System (INIS)

    Vermeer, F.J.G.

    1992-01-01

    This paper reports that by obtaining and maintaining International Standards Organization (ISO) 9001 certification, a company can improve its quality control system, cut waste, and motivate its employees. In so doing it improves its competitive position in both international and domestic markets. The success of a number of countries (notably Japan) in the world markets has focused the attention of the industrialized countries on improving quality levels and striving for a unified, worldwide quality standard. This has been particularly true in Europe; with several countries competing in a single market, a common quality standard has been a highly desirable goal for decades. One of the first multinational quality standards evolved in the European Community, which is estimated to become a single market with a gross national product of $4.5 trillion by 1992. As a consequence, in 1987 the International Standards Organization created ISO 9000, a single standard to ensure uniform quality in products and services offered with this growing market. U.S. petroleum and natural gas companies must recognize and implement the ISO 9000 standards or possibly lose international markets. If the present worldwide trend towards ISO 9000 continues (and there is no reason to believe that it will not), the standards will be just as important in the domestic market

  3. The impact of ISO 14000 on developing world businesses

    International Nuclear Information System (INIS)

    Mohamed, S.T.

    2001-01-01

    ISO 14000 has attracted interest from industry, international organizations and governments around the globe. Policy-makers and industry both appear to be looking to the standards as a key component of a new paradigm for cooperation between regulators and industry. This realization seems to have resulted from a growing awareness that the fragmented, reactive approach to environmental management in the past has not produced optimal results. Businesses are realizing the value of integrating their compliance procedures for each regulation into a broader system. Compliance problems can often be linked to system problems such as inadequate training, lack of responsibility at the right level, inadequate data, and other related causes. An effective Environmental Management System (EMS) eliminates these pitfalls. The evolution of the EMS is being shaped by market forces, ISO 9000, regulatory shifts, public awareness, and cost implications for ISO certifications. The transformation of these management practices is not limited to industrialized countries. In anticipation of the non-tariff trade barriers that could be erected as a result of these standards, many developing countries are seeking avenues of compliance with ISO 14000's requirements. Egypt should be concerned with the implementation of this system, for firms in countries of the European Community (EC) have been given explicit instructions by the three prevalent European standard-setting organizations to ''familiarize'' themselves with the requirements of ISO 14000. This paper will focus primarily on the expected effects of ISO 14001. (author)

  4. Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline.

    Science.gov (United States)

    Ayabe, Tatsuhiro; Ohya, Rena; Kondo, Keiji; Ano, Yasuhisa

    2018-03-19

    Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor γ. In this report, we demonstrated that daily intake of iso-α-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD). Body weight, epididymal fat weight, and plasma triglyceride levels were increased in HFD-fed mice, and significantly decreased in iso-α-acids supplemented HFD-fed mice. HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-α, which was significantly suppressed by iso-α-acids administration. HFD-induced neuroinflammation caused lipid peroxidation, neuronal loss, and atrophy in hippocampus, and those were not observed in iso-α-acids-treated mice. Furthermore, iso-α-acids intake significantly improved cognitive decline induced by HFD-feeding. Iso-α-acids are food derived components that suppressing both lipid accumulation and brain inflammation, thus iso-α-acids might be beneficial for the risk of dementia increased by obesity and lifestyle-related diseases.

  5. New water and remote galaxies complete ISO's observations

    Science.gov (United States)

    ISO's operational teams at ESA's ground station at Villafranca near Madrid have been hurrying to provide the world's astronomers with as many observations as possible. They have long anticipated the exhaustion of ISO's vital supply of liquid helium, which cooled the infrared telescope and its instruments to their operating temperatures, close to absolute zero. Two weeks after ISO was put into orbit on 17 November 1995 by an Ariane 44P launcher, the external parts of the cooling system had settled to the operating temperature. The specification required that ISO should then operate for at least 18 months -- implying that operations might have to end in May 1997. Thanks to superb engineering by European industry, which built the spacecraft and its super-cool telescope, ISO has given astronomers almost a year longer than that. During the extra time the count of ISO's observations of cosmic objects has risen from 16,000 to about 26,000. Among the benefits of ISO's longevity has been the chance to examine an important region of the sky, in and around the constellation of Orion. This was not accessible in the nominal mission but has now been observed in two periods. Four inter national teams, supported by national funding agencies, supplied the instruments to analyse the infrared rays received by ISO's telescope. The principal investigators leading the teams are Dietrich Lemke (Heidelberg, Germany) for the versatile photometer ISOPHOT, Catherine Cesarsky (Saclay, France) for the camera ISOCAM, Thijs de Graauw (Groningen, the Netherlands) for the Short Wavelength Spectrometer SWS, and Peter Clegg (London, UK) for the Long Wavelength Spectrometer LWS. Water vapour on Titan A big difference between ISO and the only previous infrared astronomy satellite (IRAS 1983) has been its ability to examine individual objects across a wide range of accurately defined infrared wavelengths. Many spectra showing patterns of intensities at the different wavelengths have enabled astronomers

  6. The ISO 50001 Impact Estimator Tool (IET 50001 V1.1.4) - User Guide and Introduction to the ISO 50001 Impacts Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Therkelsen, Peter L. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rao, Prakash [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Aghajanzadeh, Arian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McKane, Aimee T. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-08-01

    ISO 50001-Energy management systems – Requirements with guidance for use, is an internationally developed standard that provides organizations with a flexible framework for implementing an energy management system (EnMS) with the goal of continual energy performance improvement. The ISO 50001 standard was first published in 2011 and has since seen growth in the number of certificates issued around the world, primarily in the industrial (agriculture, manufacturing, and mining) and service (commercial) sectors. Policy makers in many regions and countries are looking to or are already using ISO 50001 as a basis for energy efficiency, carbon reduction, and other energy performance improvement schemes. The Impact Estimator Tool 50001 (IET 50001 Tool) is a computational model developed to assist researchers and policy makers determine the potential impact of ISO 50001 implementation in the industrial and service (commercial) sectors for a given region or country. The IET 50001 Tool is based upon a methodology initially developed by the Lawrence Berkeley National Laboratory that has been improved upon and vetted by a group of international researchers. By using a commonly accepted and transparent methodology, users of the IET 50001 Tool can easily and clearly communicate the potential impact of ISO 50001 for a region or country.

  7. ISO 50001 and SEP Faster and Cheaper - Exploring the Enterprise-Wide Approach

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jingjing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rao, Prakash [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Therkelsen, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sheaffer, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Scheihing, Paul [USDOE, Washington, DC (United States); Tamm, Yannick [Energetics, Inc. (United States)

    2017-06-01

    ISO 50001 and other management systems (e.g., ISO 9001 and ISO 14001) allow for implementation and certification at the enterprise level. The "Central Office" concept, which allows a small group of employees to manage and facilitate the organization’s energy management system (EnMS) at the enterprise level, was introduced within the ISO 50003 standard to provide guidance to ISO 50001 certification bodies. Four industrial companies have partnered with the United States Department of Energy to pilot the enterprise-wide ISO 50001/SEP concept under the Better Buildings Superior Energy Performance (SEP) Enterprise-wide Accelerator. Each organization developed a Central Office to host their EnMS while implementing ISO 50001/SEP at multiple physically separated sites. The four corporate partners tailored their Central Office implementation model to meet their own specific circumstances and needs. This paper reviews the commonalities, differences, and benefits of each of these enterprise-wide implementation models, including organizational structures, Central Office staff responsibilities, and key strategies. The cost savings and benefits of using the enterprise-wide approach were assessed, including the cost per site compared with that of a conventional, single-site ISO 50001/SEP implementation approach. This paper also discusses the drivers for the cost reductions realized through these enterprise-wide approaches. The four partner companies worked with 30 total sites. On average, these 30 sites improved energy performance by 5% annually over their SEP achievement periods, saved more than $600,000 annually in energy costs and reduced implementation cost for ISO 50001 and SEP by $19,000 and 0.8 Full Time Equivalent × years (FTE-yr) of staff time per site. The results can inform other organizations seeking to implement enterprise-wide ISO 50001/SEP, as well as energy efficiency organizations seeking to promote wider adoption of ISO 50001 implementation.

  8. Implementation of ISO guide 25 in a medical dosimetry secondary standards calibration laboratory

    International Nuclear Information System (INIS)

    DeWerd, L.A.

    1995-01-01

    Currently, there is a great deal of discussion among industry and government agencies about ISO 9000 accreditation. U.S. manufacturers with ISO 9000 accreditation are regarded more favorably by European countries. The principles behind the ISO 9000 accreditation are based on the Total Quality Management (TQM) principles that are being implemented in many U.S. industries. This paper will deal only with the calibration issue. There is a difference in the areas covered by ISO 9000 and ISO Guide 25 documents. ISO 9000, in particular ISO 9001 - ISO 9003, cover the open-quotes calibrationclose quotes of inspection, measuring and test equipment. This equipment is basically used for open-quotes factory calibrationsclose quotes to determine that equipment is performing within manufacturer specifications. ISO Guide 25 is specifically for open-quotes calibration and testing laboratories,close quotes generally laboratories that have painstaking procedures to reduce uncertainties and establish high accuracy of the transfer of calibration. The experience of the University of Wisconsin Accredited Dosimetry Calibration Laboratory in conforming to ISO Guide 25 will be outlined. The entire laboratory staff must become familiar with the process and an individual with direct authority must become the one to maintain the quality of equipment and calibrations in the role of open-quotes quality-assurance manager.close quotes

  9. Perancangan SMKI Berdasarkan SNI ISO/IEC27001:2013 dan SNI ISO/IEC27005:2013 (Studi Kasus DPTSI-ITS

    Directory of Open Access Journals (Sweden)

    Furqon Mauladani

    2018-03-01

    Full Text Available Institut Teknologi Sepuluh Nopember (ITS adalah salah satu universitas di Surabaya. ITS telah menggunakan TIK untuk keperluan operasional bisnisnya (contohnya isi kartu program studi, proses absensi, pembaharuan informasi, dan lainnya. Penggunaan TIK tidak dapat dipisahkan dari ancaman yang dapat mengganggu operasional TIK. Ancaman terdiri dari ancaman yang berasal dari luar (penyebaran malware, aktifitas social engineering, orang dalam (sengaja, tidak sengaja, kegagalan teknis (kesalahan penggunaan, kegagalan perangkat keras/lunak ataupun bencana alam (kebakaran, gempa, banjir. Metode yang digunakan pada penelitian ini adalah melakukan manajemen resiko keamanan informasi berdasarkan SNI ISO/IEC 27005 dan perancangan dokumen SMKI berdasarkan SNI ISO/IEC 27001. Hasil penelitian ini adalah 60 resiko yang tidak diterima dari total 228 resiko yang telah teridentifikasi. Dari 60 resiko tersebut, terdapat 58 risk modification, 1 risk avoidance, dan 1 risk sharing. Tata kelola keamanan informasi yang dirancang berdasarkan SNI ISO/IEC 27001 adalah ruang lingkup SMKI, kebijakan SMKI, proses penilaian resiko, proses penanganan resiko, statement of applicability, dan sasaran keamanan informasi.

  10. Standardization by ISO to Ensure the Sustainability of Space Activities

    Science.gov (United States)

    Kato, A.; Lazare, B.; Oltrogge, D.; Stokes, H.

    2013-08-01

    The ISO / Technical Committee 20 / Sub-committee 14 develops debris-related standards and technical reports to mitigate debris and help ensure mission and space sustainability. While UN Guidelines and the IADC Guidelines encourage national governments and agencies to promote debris mitigation design and operation, the ISO standards will help the global space industry promote and sustain its space-related business. In this paper the scope and status of each ISO standard is discussed within an overall framework. A comparison with international guidelines is also provided to demonstrate the level of consistency. Finally, as a case study, the ISO standards are applied to a CubeSat mission, thus demonstrating their usability on a relatively recent and popular class of satellite.

  11. Isoe - information system on occupational exposure. Ten years of experience

    International Nuclear Information System (INIS)

    2002-01-01

    The information System on Occupational Exposure (ISOE) was created in 1992 to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and co-ordinate international co-operative undertakings in the area of worker protection at nuclear power plants. The ISOE System is jointly managed by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). This report provides an overview of the experience gained from, and benefits provided by, the ISOE System over the past ten years. Active participation of a large number of utilities in ISOE has contributed to a reduction in occupational exposure at nuclear power plants worldwide. (authors)

  12. [Efforts to achieve and effects of acquiring ISO 15189 in Tokushima University Hospital].

    Science.gov (United States)

    Shono, Kazuko; Kishi, Misako; Satou, Mituyo; Nagamine, Yasunori; Doi, Tosio

    2009-12-01

    The medical laboratory of Tokushima University Hospital acquired ISO 15189, an international standard for medical laboratories, on July 6th, 2007, resulting in it achieving the 24th place in Japan and 5th place among national university hospitals. The first surveillance was just performed on October 6th, 2008. Tokushima University Hospital, in which our medical laboratory is included as one section, already succeeded in acquiring ISO 9001, PrivacyMark System, and Quality Health Care ver. 5 before accomplishing ISO 15189. To achieve ISO 15189, we prepared documents based on ISO 9001 without any consultation, resulting in a review of the difference between ISO 9001 and ISO 15189 after the preliminary survey. Although achieving ISO 15189 resulted in an improvement in the reliability of laboratory results and accuracy, leading to the development of our technical skills and awareness, and sharing of knowledge, we consider that the considerable investment of time to prepare the requirements remains to be overcome.

  13. 77 FR 11532 - Notice of Attendance at ISO New England and NEPOOL Meetings

    Science.gov (United States)

    2012-02-27

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Attendance at ISO New England... members of the Commission and Commission staff may attend upcoming ISO New England Inc. (ISO-NE) and New..., the Commission and Commission staff may monitor the various meetings posted on the ISO-NE Web site...

  14. ISO 14001 ENVIRONMENTL MANAGEMENT SYSTEMS IN GOVERNMENT AND INDUSTRY

    Science.gov (United States)

    Two new USEPA documents address environmental management systems (EMS) from the perspectives of government and industry and are offered as tools for understanding the process of the ISO 14000 Standards development and usefulness of an EMS approach. The first document, ISO 14001 -...

  15. IS ISO 9000 CERTIFICATION LOSING ITS CREDIBILITY?

    Directory of Open Access Journals (Sweden)

    P.R. Ramesh

    2013-03-01

    Full Text Available ISO certification was a great hope for many stakeholders in India for making the country strong in terms of quality practices. It was a blessing in disguise when in early nineties; buyers were imposing conditions that you should be ISO compliant to do business with them. ISO was a great system to bring in improvements in the way an organization functions. But unfortunately some have adopted a short cut approach in getting the certification done. It is only just before the audit team comes for re-inspection that firms start removing dust from the quality manual files so that they can pretend that that they follow those systems. But a real commitment to adhering to these systems is missing. The paper describes such scenario existing in some quarters in India and warns against such practices for the overall good of the system.

  16. ISO Results Presented at International Astronomical Union

    Science.gov (United States)

    1997-08-01

    Some of the work being presented is collected in the attached ESA Information Note N 25-97, ISO illuminates our cosmic ancestry. A set of six colour images illustrating various aspects have also been released and are available at http://www.estec.esa.nl/spdwww/iso1808.htm or in hard copy from ESA Public Relations Paris (fax:+33.1.5369.7690). These pictures cover: 1. Distant but powerful infrared galaxies 2. A scan across the milky way 3. Helix nebula: the shroud of a dead star 4. Supernova remnant Cassiopeia A 5. Trifid nebula: a dusty birthplace of stars 6. Precursors of stars and planets The International Astronomical Union provides a forum where astronomers from all over the world can develop astronomy in all its aspects through international co-operation. General Assemblies are held every three years. It is expected that over 1600 astronomers will attend this year's meeting, which is being held in Kyoto, Japan from 18-30 August. Further information on the meeting can be found at: www.tenmon.or.jp/iau97/ . ISO illuminates our cosmic ancestry The European Space Agency's Infrared Space Observatory, ISO, is unmatched in its ability to explore and analyse many of the universal processes that made our existence possible. We are children of the stars. Every atom in our bodies was created in cosmic space and delivered to the Sun's vicinity in time for the Earth's formation, during a ceaseless cycle of birth, death and rebirth among the stars. The most creative places in the sky are cool and dusty, and opaque even to the Hubble Space Telescope. Infrared rays penetrating the dust reveal to ISO hidden objects, and the atoms and molecules of cosmic chemistry. "ISO is reading Nature's recipe book," says Roger Bonnet, ESA's director of science. "As the world's only telescope capable of observing the Universe over a wide range of infrared wavelengths, ISO plays an indispensable part in astronomical discoveries that help to explain how we came to exist." This Information Note

  17. Revision of the ISO and EN radiation sterilization standards

    DEFF Research Database (Denmark)

    Miller, A.; Hansen, J.

    2002-01-01

    The radiation sterilization standards, ISO 11137 and EN 552, are now being revised under "ISO lead", with the aim of producing only one international standard, although in four parts: (1) requirements. (2) dose-setting methods, (3) dose-substantiation methods and (4) dosimetry. Several aspects...

  18. Measuring the Software Product Quality during the Software Development Life-Cycle: An ISO Standards Perspective

    OpenAIRE

    Rafa E. Al-Qutaish

    2009-01-01

    Problem statement: The International Organization for Standardization (ISO) published a set of international standards related to the software engineering, such as ISO 12207 and ISO 9126. However, there is a set of cross-references between the two standards. Approach: The ISO 9126 on software product quality and ISO 12207 on software life cycle processes had been analyzed to invistigate the relationships between them and to make a mapping from the ISO 9126 quality characteristics to the ISO 1...

  19. USGIN ISO metadata profile

    Science.gov (United States)

    Richard, S. M.

    2011-12-01

    The USGIN project has drafted and is using a specification for use of ISO 19115/19/39 metadata, recommendations for simple metadata content, and a proposal for a URI scheme to identify resources using resolvable http URI's(see http://lab.usgin.org/usgin-profiles). The principal target use case is a catalog in which resources can be registered and described by data providers for discovery by users. We are currently using the ESRI Geoportal (Open Source), with configuration files for the USGIN profile. The metadata offered by the catalog must provide sufficient content to guide search engines to locate requested resources, to describe the resource content, provenance, and quality so users can determine if the resource will serve for intended usage, and finally to enable human users and sofware clients to obtain or access the resource. In order to achieve an operational federated catalog system, provisions in the ISO specification must be restricted and usage clarified to reduce the heterogeneity of 'standard' metadata and service implementations such that a single client can search against different catalogs, and the metadata returned by catalogs can be parsed reliably to locate required information. Usage of the complex ISO 19139 XML schema allows for a great deal of structured metadata content, but the heterogenity in approaches to content encoding has hampered development of sophisticated client software that can take advantage of the rich metadata; the lack of such clients in turn reduces motivation for metadata producers to produce content-rich metadata. If the only significant use of the detailed, structured metadata is to format into text for people to read, then the detailed information could be put in free text elements and be just as useful. In order for complex metadata encoding and content to be useful, there must be clear and unambiguous conventions on the encoding that are utilized by the community that wishes to take advantage of advanced metadata

  20. ISO CD 14492

    DEFF Research Database (Denmark)

    Martins, Bo; Kossentini, F.; Arps, R.

    1998-01-01

    This Recommendation | International Standard, informally called JBIG2, defines a coding method for bilevel images, that is, images consisting of a single rectangular bit plane, with each pixel taking on one of just two possible colors. Itis being drafted by the Joint Bi-level Image Experts Group ...... (JBIG), a "Collaborative team" that reports both to ISO/IEC JTC1/SC29/WG1 and to ITU-T/SG8....

  1. Implications of ISO 9000 for personnel dosimetry

    International Nuclear Information System (INIS)

    Yoder, R.C.

    1995-01-01

    Landauer, Inc. has gained approval to provide personnel dosimetry services in several countries. Each experiene reflects the different concerns adopted by national approval agencies. None have adopted ISO 9000 registration as evidence of a suitable quality system of management. Instead, each organization has prepared its own set of requirements with no provisions for recognizing the results of performance tests or audits conducted by other approval organizations. As ISO 9000 has become a communication symbol for commercial organizations dealing with each other, it has not been similarly viewed by radiation regulation bodies. A key reason arises from a tradition to regulate bodies. A key reason arises from a tradition to regulate, not promote, international trade, not encourage innovation, nor foster economic competition. A second reason is the inability to separate the technical requirements from quality assurance. ISO 9000 may become useful once the national technical organizations learn to trust those of other countries

  2. IMPLEMENTASI SISTEM MANAJEMEN MUTU BERBASIS ISO 9001:2000 PADA SEKOLAH MENENGAH KEJURUAN

    Directory of Open Access Journals (Sweden)

    Mardi Wiyono

    2012-09-01

    Full Text Available Abstract: The implementation of ISO 9001:2000 quality management system in vocational school. The needs of quality products and services is largerly expanded in various organizations including education. Recently, the vocational schools also realize how important the quality product and service is. For achieving the quality product or service, some organizations implement the concept of ISO 9001:2000 quality management system. In 2006/2007 it is reported that there are some vocational schools have been certified with ISO 9001:2000. ISO 9001 is a serial document consists of Quality Management System Standard which has been refised from its previous standard. ISO 9001:2000 gives a number of prerequisites for organizations having business initialized by design and development, production, installations, and services. The vocational schools which have been certified with ISO 9001:2000, have to be re-accredited after three years of implementation.

  3. Modelovanje georeferenciranih podataka u katastru nepokretnosti primenom ISO 19100 serije standarda / Spatial data modeling in the real estate cadastre using ISO 19100 series of standards

    Directory of Open Access Journals (Sweden)

    Mirko N. Petrović

    2010-01-01

    Full Text Available Potreba za standardizacijom u oblasti geografskih informacionih sistema odavno postoji. Međunarodne aktivnosti na ovom polju rezultirale su uspostavljanjem ISO 19100 serije standarda, kojima se regulišu različiti aspekti na polju geoinformatike. U članku su opisane mogućnosti primene relevantnih standarda iz serije ISO 19100 u modelovanju georeferenciranih podataka za katastar nepokretnosti. / Introduction Standardization in geo-information technologies contributes to the establishment of efficient information functions, their greater stability and easier transition. Application of international, national and internal standards in the process of developing software products in the field of geo-information technology creates conditions for the development of efficient, low cost, reliable and secure software products. Spatial data modeling basics for real estate cadastre In terms of modeling, the spatial information of real estate cadastre is based on the vector data model which is suitable for modeling objects with a smaller number of properties with emphasis on the position. The vector spatial data model consists of two components: spatial and descriptive. The basis of the spatial one is geometry that contains metric data usually given in coordinates of a reference system. Geometry and Topology uniquely determine the shape, size and position of the object model in space, i.e. they represent its spatial component. Merging the spatial component with the descriptive one results in a completely defined object from the real world. Elements of spatial data quality Spatial data quality can be reviewed through a set of the following elements: origin, positional accuracy, attribute accuracy, completeness, logical consistency, semantic accuracy and the time information. The elements of spatial data quality listed above are provided using ISO 19100 series of standards. Application of ISO19100 series of standards in spatial data modeling for real

  4. Reasons to Adopt ISO 50001 Energy Management System

    Directory of Open Access Journals (Sweden)

    Frederic Marimon

    2017-09-01

    Full Text Available Purpose: The main aim of this paper is to analyze the relationships between the corporate motivations that lead organizations to establish the ISO 50001 Energy Management System (EnMS standard, and the difficulties and benefits derived from its adoption. Design/methodology/approach: Three independent exploratory factor analyses (EFA were conducted in order to identify (i sources of motivation: social requirements, ecology drivers, and competitive advantage; (ii the difficulties of an ISO 50001 adoption: operational difficulties and organizational difficulty; and (iii types of benefits: ecological benefits and operational benefits. In a second step, an exploratory path analysis, performed through Structural Equation Modeling (SEM, was used to analyze the relations among motivation, difficulties, and benefits related to the adoption of the ISO 50001 standard. Findings: Social requirements explain operational difficulties, which in turn impacts on operational benefits. Ecology drivers are directly related to ecological benefits. Organizational difficulties have an inverse relationship with operational and ecological benefits. Operational difficulties are related to operational benefits and ecological benefits. Research limitations/implications: The questionnaire was disseminated to 87 Spanish companies with ISO 50001 certification. Managers and other practitioners such as consultants, auditing companies, and official organizations in charge of developing standards might find useful implications. Originality/value: The standard was published in 2011 by the International Organization for Standardization (ISO. This paper contributes to assessment of the benefits of the standard by collecting information directly from the pioneer organizations that have adopted it, and provides clues on how to implement the standard and improve it in future.

  5. Energy care in relation to your management system. Linking lists between the Reference Energy Care and ISO 14001, ISO 9001 and HACCP; Energiezorg in relatie tot uw zorgsysteem. Linking lists tussen de Referentie Energiezorg en ISO 14001, ISO 9001 en HACCP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Several so-called care systems are in use at institutes and companies. For efficiency reasons it makes sense to integrate an energy care system to the existing care system. For the so-called Reference Energy Care, developed by the Netherlands Agency for Energy and the Environment (Novem) links to three of the most important care systems have been elaborated: environmental care according to ISO 14001, the quality care system ISO 9001:2000 and the food safety system Hazard Analysis Critical Control Points (HACCP). The elaboration resulted in three tables, indicating the connections ('linking lists') between each of those care systems and the Reference Energy Care system and how energy care can be integrated into those systems. [Dutch] Bij instellingen en bedrijven zijn diverse zorgsystemen in gebruik. Het is zinvol om energiezorg - waar mogelijk - in een dergelijk bestaand systeem op te nemen. Meerdere zorgsystemen naast elkaar in stand houden is minder efficient dan de systemen integreren tot een systeem. Novem heeft daarom voor haar Referentie Energiezorg de link laten uitwerken naar drie van de meest voorkomende systemen: milieuzorg volgens ISO 14001, het kwaliteitszorgsysteem ISO 9001:2000 en het voedselveiligheidssysteem HACCP (Hazard Analysis Critical Control Points). Hieruit zijn drie tabellen voortgekomen, die aangeven welke verbanden er zijn tussen elk van deze zorgsystemen en de Referentie Energiezorg en hoe u energiezorg kunt integreren in elk van deze systemen. Deze tabellen worden aangeduid als 'linking lists' en u kunt ze gebruiken als hulpmiddel bij het integreren van energiezorg in uw eigen zorgsysteem. U vindt ze in deze brochure.

  6. Energy care in relation to your management system. Linking lists between the Reference Energy Care and ISO 14001, ISO 9001 and HACCP; Energiezorg in relatie tot uw zorgsysteem. Linking lists tussen de Referentie Energiezorg en ISO 14001, ISO 9001 en HACCP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Several so-called care systems are in use at institutes and companies. For efficiency reasons it makes sense to integrate an energy care system to the existing care system. For the so-called Reference Energy Care, developed by the Netherlands Agency for Energy and the Environment (Novem) links to three of the most important care systems have been elaborated: environmental care according to ISO 14001, the quality care system ISO 9001:2000 and the food safety system Hazard Analysis Critical Control Points (HACCP). The elaboration resulted in three tables, indicating the connections ('linking lists') between each of those care systems and the Reference Energy Care system and how energy care can be integrated into those systems. [Dutch] Bij instellingen en bedrijven zijn diverse zorgsystemen in gebruik. Het is zinvol om energiezorg - waar mogelijk - in een dergelijk bestaand systeem op te nemen. Meerdere zorgsystemen naast elkaar in stand houden is minder efficient dan de systemen integreren tot een systeem. Novem heeft daarom voor haar Referentie Energiezorg de link laten uitwerken naar drie van de meest voorkomende systemen: milieuzorg volgens ISO 14001, het kwaliteitszorgsysteem ISO 9001:2000 en het voedselveiligheidssysteem HACCP (Hazard Analysis Critical Control Points). Hieruit zijn drie tabellen voortgekomen, die aangeven welke verbanden er zijn tussen elk van deze zorgsystemen en de Referentie Energiezorg en hoe u energiezorg kunt integreren in elk van deze systemen. Deze tabellen worden aangeduid als 'linking lists' en u kunt ze gebruiken als hulpmiddel bij het integreren van energiezorg in uw eigen zorgsysteem. U vindt ze in deze brochure.

  7. 21 CFR 184.1165 - n-Butane and iso-butane.

    Science.gov (United States)

    2010-04-01

    ... FOR HUMAN CONSUMPTION (CONTINUED) DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE Listing of Specific Substances Affirmed as GRAS § 184.1165 n-Butane and iso-butane. (a) n-Butane and iso..., odorless, flammable gases at normal temperatures and pressures. They are easily liquefied under pressure at...

  8. Juhtimissüsteemide selgroog. Lean ning ISO - terviklahendused tootmise haldamiseks / Anton Ovsjankin

    Index Scriptorium Estoniae

    Ovsjankin, Anton

    2011-01-01

    Kasvanud on juurutatavate Lean ja ISO süsteemide arv, kuid on kasvanud ka nende juurutamise ja arendamisega seotud ebaõnnestumiste arv. Põhjustest, miks jäävad paljud Leani ja ISO juurutanud ettevõtted ilma lubatud tulemusteta. Leani ja ISO haldamiseks vajalikest teguritest

  9. ISO 14000: Review and guidelines for the photovoltaic industry

    Energy Technology Data Exchange (ETDEWEB)

    DePhillips, M.P.

    1997-08-01

    The International Organization for Standardization (ISO) has released and is in the process of ratifying a new set of environmental management system standards, ISO 14000. These voluntary international standards will have a significant impact on how companies throughout the international community manage their environmental programs. Initially this impact will result in increased international trade opportunities due to the anticipated customer requirement for suppliers to demonstrate certification. Other potential impacts will benefit both companies engaged in international commerce and companies with a domestic focus. These would include installing a cohesive system to manage environmental matters, participation within a new regulatory paradigm, and adhering to a potentially new set of legal standards. The wide range of potential environmental, commercial, legal and regulatory benefits offered by ISO 14000 offer most companies significant reason to explore the possibilities of implementing an environmental management system. Organizations will be able to anticipate and meet growing environmental expectations and to ensure ongoing compliance with national and international requirements as well as satisfy the growing demands of customers, stakeholders and the interested public. As an emerging industry with significant international ties, the photovoltaic (PV) community will be effected from these standards if they do become globally adopted. In fact some major players in the PV industry have recently received certification to ISO 9000. This again demonstrates a trend within the industry to move toward a uniform system approach to management. This paper will expose interested parties within the PV industry to the details of ISO 14000 and will assist decision makers assess the various possibilities for implementation certification of ISO 14000 for an individual facility.

  10. ISO 9000. Guidelines to increased costs and reduced product quality

    International Nuclear Information System (INIS)

    Reedy, R.F.

    1994-01-01

    Many US companies are considering being registered to the provisions of ISO 9000, International Standards for Quality Management. One important problem with the document is that ISO 9000 is not focused on control of product quality. The quality assurance rules established in ISO 9000 have been used in the US for more than 25 years with disastrous financial consequences and little, if any, improvement in quality and safety. These rules are so reliant on documentation and strict compliance that ensuring products comply with specifications has become a secondary issues. That is not what was intended, but it is the result. ISO 9000 program can work effectively only when the top executive responsible for engineering or production takes full responsibility for interpretation and implementation of the quality assurance program. 3 refs., 1 tab

  11. OntoCR: A CEN/ISO-13606 clinical repository based on ontologies.

    Science.gov (United States)

    Lozano-Rubí, Raimundo; Muñoz Carrero, Adolfo; Serrano Balazote, Pablo; Pastor, Xavier

    2016-04-01

    To design a new semantically interoperable clinical repository, based on ontologies, conforming to CEN/ISO 13606 standard. The approach followed is to extend OntoCRF, a framework for the development of clinical repositories based on ontologies. The meta-model of OntoCRF has been extended by incorporating an OWL model integrating CEN/ISO 13606, ISO 21090 and SNOMED CT structure. This approach has demonstrated a complete evaluation cycle involving the creation of the meta-model in OWL format, the creation of a simple test application, and the communication of standardized extracts to another organization. Using a CEN/ISO 13606 based system, an indefinite number of archetypes can be merged (and reused) to build new applications. Our approach, based on the use of ontologies, maintains data storage independent of content specification. With this approach, relational technology can be used for storage, maintaining extensibility capabilities. The present work demonstrates that it is possible to build a native CEN/ISO 13606 repository for the storage of clinical data. We have demonstrated semantic interoperability of clinical information using CEN/ISO 13606 extracts. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. 75 FR 51996 - Notice of Commission Staff Attendance at Midwest ISO Meetings

    Science.gov (United States)

    2010-08-24

    ... Midwest ISO Meetings August 16, 2010. The Federal Energy Regulatory Commission hereby gives notice that members of the Commission and Commission staff may attend the following Midwest ISO-related meetings...., St. Paul, MN) [cir] September 15 [cir] October 20 [cir] November 17 [cir] December 1 Midwest ISO...

  13. ISO celebrates its prolonged life with a video of Jupiter

    Science.gov (United States)

    1997-07-01

    This is excellent news for astronomers and especially for the multinational teams, with leaders in France, Germany, the Netherlands and the United Kingdom, who spent many years devising the four instruments served by ISO's telescope. The camera ISOCAM, the photometer ISOPHOT, the Short Wavelength Spectrometer and the Long Wavelength Spectrometer span between them an unprecedented range of infrared wavelengths from 2 to 200 microns. The atmosphere of Jupiter is one of the cool and cloudy places attracting ISO's attention, and ESA today releases a video of unprecedented images of Jupiter. The planet changes its appearance drastically as the camera ISOCAM scans a range of 90 different infrared wavelengths. Picture by picture, ISOCAM picks out different features of the atmosphere's composition and behaviour. These and other results from ISO will enable scientists to sharpen their ideas about how Jupiter's weather works. "ISO is giving us a new impression of the giant planets of the Solar System," comments Roger Bonnet, ESA's director of science. "Not just Jupiter, but Saturn, Uranus and Neptune too. By observing the planets across its very wide range of infrared wavelengths, ISO can see features overlooked even by spacecraft visiting the planets. The remarkable movie of Jupiter released today represents only a few per cent of ISO's wavelength range, yet every image tells its own story." More information about the Jupiter video appears later in this Information Note. How ISO's cold telescope beat the calendar The need to keep ISO's telescope and instruments chilled to a very low temperature sets a limit to their useful operating life. ISO was supplied with more than 2000 litres of superfluid helium to cool it. Slow evaporation maintains key parts of the spacecraft at temperatures close to absolute zero, below minus 271 degrees C. The rate of loss of helium was expected to be about 3 litres a day, but the cryogenic system could not be tested in exactly the conditions

  14. ISO standardization in nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Brabec, D [Ustav pro Vyzkum, Vyrobu a Vyuziti Radioisotopu, Prague (Czechoslovakia); Cermak, O [Urad pro Normalizaci a Mereni, Prague (Czechoslovakia)

    1984-10-01

    The activity is described of the technical commission ISO/TC 85 which is currently divided into 4 subcommissions (SC) and 24 working groups. SC 1 ''Terminology, definitions, units, abbreviations'' has one working group. The most important document of this SC is ISO 921-1972 (Dictionary of nuclear technology). SC 2 ''Radiation protection'' has 9 working groups and has processed standards in dosimetry. SC 3 ''Technology of power reactors'' has 6 working groups and its work is related to IAEA activities within the NUSS program. SC 4 ''Technology of nuclear fuels'' has 8 working groups. SC 4 has compiled the basic standards for sealed sources and methods of testing their tightness. The results of the work of this group have been reflected into the standardization work of CMEA. A list is given of published international standards within TC 85.

  15. Pressure-dependent kinetics of initial reactions in iso-octane pyrolysis.

    Science.gov (United States)

    Ning, HongBo; Gong, ChunMing; Li, ZeRong; Li, XiangYuan

    2015-05-07

    This study focuses on the studies of the main pressure-dependent reaction types of iso-octane (iso-C8H18) pyrolysis, including initial C-C bond fission of iso-octane, isomerization, and β-scission reactions of the alkyl radicals produced by the C-C bond fission of iso-octane. For the C-C bond fission of iso-octane, the minimum energy potentials are calculated at the CASPT2(2e,2o)/6-31+G(d,p)//CAS(2e,2o)/6-31+G(d,p) level of theory. For the isomerization and the β-scission reactions of the alkyl radicals, the optimization of the geometries and the vibrational frequencies of the reactants, transition states, and products are performed at the B3LYP/CBSB7 level, and their single point energies are calculated by using the composite CBS-QB3 method. Variable reaction coordinate transition state theory (VRC-TST) is used for the high-pressure limit rate constant calculation and Rice-Ramsperger-Kassel-Marcus/master equation (RRKM/ME) is used to calculate the pressure-dependent rate constants of these channels with pressure varying from 0.01-100 atm. The rate constants obtained in this work are in good agreement with those available from literatures. We have updated the rate constants and thermodynamic parameters for species involved in these reactions into a current chemical kinetic mechanism and also have improved the concentration profiles of main products such as C3H6 and C4H6 in the shock tube pyrolysis of iso-octane. The results of this study provide insight into the pyrolysis of iso-octane and will be helpful in the future development of branched paraffin kinetic mechanisms.

  16. Energy management systems in the practice. ISO 50001. A guideline for companies and institutions; Energiemanagementsysteme in der Praxis. ISO 50001. Leitfaden fuer Unternehmen und Organisationen

    Energy Technology Data Exchange (ETDEWEB)

    Kohlenborn, Walter; Kabisch, Sibylle; Klein, Johanna; Richter, Ina; Schuermann, Silas

    2012-06-15

    The guideline under consideration is an updated version of the guideline to the regulation EN 16001 and amended to ISO 50001. This contribution supports institutes in the implementation of an energy management system according to ISO 50001. The differences and commonalities to the European environment management system EMAS as well as to the regulation ISO 14001 are described. EMAS certified companies fulfil regularly all conditions of an energy management system. A practised energy management system is an excellent platform for the implementation of EMAS.

  17. 76 FR 4104 - Notice of Commission Staff Attendance at Midwest ISO Meetings

    Science.gov (United States)

    2011-01-24

    ... Midwest ISO Meetings January 13, 2011. The Federal Energy Regulatory Commission hereby gives notice that members of the Commission and Commission staff may attend the following Midwest ISO-related meetings...] September 14 [cir] October 19 [cir] November 16 [cir] December 6 Midwest ISO Informational Forum (3 p.m.-5 p...

  18. 75 FR 3228 - Notice of Commission Staff Attendance at Midwest ISO Meetings

    Science.gov (United States)

    2010-01-20

    ... Midwest ISO Meetings January 12, 2010. The Federal Energy Regulatory Commission hereby gives notice that members of the Commission and Commission staff may attend the following Midwest ISO-related meetings...] November 17 [cir] December 1 Midwest ISO Informational Forum (3 p.m.-5 p.m., ET) [cir] January 19 [cir...

  19. KSC Center Director Bridges accepts an ISO 9001 certificate from DNV

    Science.gov (United States)

    1998-01-01

    Center Director Roy Bridges displays the ISO 9001 certificate he was awarded by Det Norske Veritas (DNV), Inc., an international ISO certification organization, at a ceremony at KSC. Dalton Lyon of DNV made the presentation, which included a 2000th ISO Certificate Plaque. ISO 9001 comprises the most detailed, comprehensive set of standard requirements for quality programs established by the International Standards Organization. The presentation followed a successful independent audit by DNV of the KSC Management System in May of this year. The third-party auditors examined about 20 elements of KSC's system, including management responsibility, design control, documentation, test and inspection, and corrective action procedures. DNV found that KSC met or exceeded the stringent quality standards in all areas. KSC will use this certification as a tool to improve an already world-class team. All NASA centers are required by NASA Administrator Daniel S. Goldin to be ISO 9001 registered by September 1999. NASA is the first federal agency to seek the quality certification.

  20. Competence Requirements of ISO/IEC Standards for Information Security Professionals

    Directory of Open Access Journals (Sweden)

    Natalia G. Miloslavskaya

    2017-11-01

    Full Text Available The rapid progress in the filed of information security (IS puts one in a need of periodic revision of professional competencies (formulated in the federal state educational standards –FSESs and working functions (formulated in the professional standards – PSs. Under these conditions, a timely reaction to everything new that emerges or will appear in modern regulatory documents (primarily in standards is extremely important. We make a forecast for the content of the ISO/IEC 27021 and ISO/IEC 19896 standards drafted by the International Organization for Standardization (ISO, which should contain the requirements for the competencies of IS management system professionals and the competence of IS testers and evaluators. Our forecast takes into account the requirements of the ISO/IEC 27000 standard group and the recommendations of the European e-Competence Framework e-CF 3.0.

  1. Migración de un SGSI basado en ISO/IEC 27001:2005 a la versión ISO/IEC 27001:2013

    OpenAIRE

    Espol; Rendón Freire, María José

    2015-01-01

    Este proyecto tiene como objetivo identificar los cambios en los requisitos de la norma ISO/IEC 27001:2013 respecto a la versión 2005, para lograr la actualización de un sistema de gestión de seguridad de la información basado en ISO/IEC 27001:2005 acorde a lo establecido en el nuevo estándar. Guayaquil Magíster en Seguridad Informática Aplicada

  2. Sifting through the ISO 9000 maze

    International Nuclear Information System (INIS)

    Abraham, K.S.

    1993-01-01

    Various forces in the global upstream market are more frequently pressuring equipment and services firms to be certified according to the latest international standards in order to do business. However, understanding and completing the registration process can appear confusing and intimidating at first glance. This paper reviews the ISO's 9000 series of generic standards that provide quality assurance requirements and management guidance. It describes its applicability to the oil and gas industry which often found itself cut out of international markets because they were not recognized as registered ISO participants. It then describes the registration process, evaluation process, and time tables involved. It also describes the difference performance standards of the 9000 series

  3. IMPLEMENTING AN ISO 10001-BASED PROMISE IN INPATIENTS CARE

    Directory of Open Access Journals (Sweden)

    Mohammad Ashiqur Rahman Khan

    2013-09-01

    Full Text Available This paper presents the implementation of a Customer Satisfaction Promise (CSP that requires nurses to introduce themselves and explain the care plan to the patients of a hospital unit in Canada. The CSP implementation, maintenance and improvement activities were based on ISO 10001:2007. Qualitative and quantitative performance data were collected from nurses, the unit manager and patients, and improvement suggestions were made. During the implementation, nurses introduced themselves 95% of the time and explained the care plan 86% of the time. When interviewed, some nurses stated that the CSP was a good reinforcement of a practice already expected of them, which made patients happy, satisfied and more comfortable. Data from a small sample of patients was not adequate in clearly indicating the CSP's performance or improvement, but was useful in validating the survey and the feedback form. To our knowledge, applications of ISO 10001:2007 in health care have not been studied. Furthermore, this paper may be the first example of the integrated use of ISO 10001 and ISO 10002 in health care.

  4. Towards better GHG emissions savings with use of ISO GHG standards

    International Nuclear Information System (INIS)

    Chan Kook Weng

    2010-01-01

    The 15th Conference of Parties (COP 15) at Copenhagen, Denmark in December 2009 highlighted the need to combat climate change by facing the challenge of committing to reducing our emissions at all three levels with locally appropriate mitigation actions (LAMAs) at the local level to be linked to the nationally appropriate mitigation actions (NAMAs) and then contribute onwards to globally appropriate mitigation actions (GAMAs). The aim is to find solutions for both adaptation and mitigation by ensuring sufficient means are made available to support such efforts. This is because the world in entering a new phase that will be characterised by green growth in business. Thus be it agriculture that uses local knowledge of specific crop and livestock varieties to help in secure food supply, bio-energy, transport, industries, there must be policies to understand ecosystem-based to link people, biodiversity, energy, water and carbon so as to be more resilient and adaptable to the need for a low carbon economy in todays society.Climate change therefore affects organisations in many areas and they include legal compliance, carbon market, corporate social responsibility and sustainable development. Promoting sustainability requires making efficient use of energy, water and natural resources, decrease in waste load through recycling and streamlining the processes leading to everything that decreases their CO 2 and water footprints. Currently there are many GHG schemes and programmes and the issues centres around compatibility, costs and most importantly credibility. Achieving real GHG emissions reduction requires controlled and verified emissions reductions and quantification that are sound and verifiable. Thanks to the development of the ISO suite of standards on GHG and related matters, the use of these harmonised standards has given the assurance that a tonne of carbon is a tonne of carbon be it in Malaysia, Mali or Mongolia.The use of these standards like ISO 14064 Part 1

  5. On results of tests of thermal insulation structural fragments for in-vessel equipment and pipelines of the VG-400 plant on vibrational and acoustic loads

    International Nuclear Information System (INIS)

    Ledenko, S.A.; Andreev, V.A.; Mirenkov, A.F.; Zakharov, V.A.; Suvorov, V.E.; Prokimnov, V.V.

    1990-01-01

    Results of vibrostrength and acoustic fatigue tests of the fragments of thermal insulation for in-vessel equipment and pipelines of the VG-400 reactor are presented. The insulation structure is based on the insulation layer made of steel foil and carbon materials. Weak points in the insulation structure, namely - the welded joints of stiffening ribs - are detected in the course of testing. A conclusion is made on the possibility of vibrational test substitution for the acoustic ones

  6. Evaluating Education Quality in Terms of ISO9000 Standards

    Science.gov (United States)

    Fengchun, Cheng; Vogel, Linda R.; Zhaoyu, Zheng

    2014-01-01

    While nations measure the quality of educational systems by different standards, many nations, such as China, have adopted the ISO9000 quality standards to assess the quality of schools. This article explores the various elements of the the ISO9000 standards and how each element relates to the various groups that are consumers or stakeholders in…

  7. Establishing an ISO 10001-based promise in inpatients care.

    Science.gov (United States)

    Khan, Mohammad Ashiqur Rahman; Karapetrovic, Stanislav

    2015-01-01

    The purpose of this paper is to explore ISO 10001:2007 in planning, designing and developing a customer satisfaction promise (CSP) intended for inpatients care. Through meetings and interviews with research participants, who included a program manager, unit managers and registered nurses, information about potential promises and their implementation was obtained and analyzed. A number of promises were drafted and one was finally selected to be developed as a CSP. Applying the standard required adaptation and novel interpretation. Additionally, ISO 10002:2004 (Clause 7) was used to design the feedback handling activities. A promise initially chosen for development turned out to be difficult to implement, experience that helped in selecting and developing the final promise. Research participants found the ISO 10001-based method useful and comprehensible. This paper presents a specific health care example of how to adapt a standard's guideline in establishing customer promises. The authors show how a promise can be used in alleviating an existing issue (i.e. communication between carers and patients). The learning can be beneficial in various health care settings. To the knowledge, this paper shows the first example of applying ISO 10001:2007 in a health care case. A few activities suggested by the standard are further detailed, and a new activity is introduced. The integrated use of ISO 10001:2007 and 10002:2004 is presented and how one can be "augmented" by the other is demonstrated.

  8. Correspondence of ISO 9001:2008 with IAEA GS-R-3

    International Nuclear Information System (INIS)

    Kibrit, Eduardo

    2009-01-01

    This article identifies, characterises and analyses International Organisation for Standardisation (ISO) and International Atomic Energy Agency (IAEA) normative requirements for the development and implementation of quality management systems in nuclear organisations. The structures of the applicable standards, ISO 9001:2008 and IAEA GS-R-3, are characterised. The differences and similarities of objective, focus, scope, level of application, structure, vocabulary, management system, management responsibility, resource management, process implementation, measurement, assessment and improvement verified in the applicable standards are deeply reviewed. A correspondence of the applicable standards' requirements is presented topic by topic. A correlation of the applicable standards' requirements is made, showing IAEA GS-R-3 topics that have no correlation with ISO 9001:2008 and ISO 9001:2008 topics that have no correlation with IAEA GS-R-3. Conclusive remarks advise the pros and cons of using one of the applicable standards or the other. (author)

  9. [Approval of ISO/IEC 17025 and quality control of laboratory testing].

    Science.gov (United States)

    Yamamoto, Shigeki; Asakura, Hiroshi; Machii, Kenji; Igimi, Shizunobu

    2010-01-01

    First section of Division of Biomedical Food Research, National Institute of Health Sciences (NIHS) was approved by ISO/IEC 17025 as a laboratory having an appropriate laboratory testing technique. NIHS is the first national laboratory approved by ISO/IEC 17025. NIHS has also been accepted the appropriate technique and facility for the BSL3 level pathogens by ISO/IEC 17025. NIHS is necessary to take an external audit almost every year. This approval is renewed every 4 years.

  10. ISO 9000 IMPLEMENTATION AND PERCEIVED ORGANISATIONAL OUTCOME: THE CASE OF A SERVICE ORGANISATION

    Directory of Open Access Journals (Sweden)

    Jasni Abdul Latif

    2003-01-01

    Full Text Available The study examines the relationship between the perceptions of the employees about ISO 9000 implementation and perceived organisational outcomes. A conceptual framework linking the level of employee influence and involvement, their perception of ISO 9000 and the perceived impact on their work and the organisational outcomes is posited. Data was collected from a random sample of 64 employees of a service organisation. Contrary to expectations, the work impact of ISO 9000 was not correlated with the efficiency and market outcomes of ISO 9000 certification but the employee involvement, influence and perception of ISO 9000 were. The conceptualization of the influence path of ISO 9000 implementation on the organisational outcomes may require rethinking as perception may have a direct effect on the outcomes without the mediation of the impact on work. In short, employees may report benefits or positive outcomes even though no change is reported in their work.

  11. ISO 14000 and the nuclear licensing

    International Nuclear Information System (INIS)

    Martins, Nadia Soido Falcao

    1999-01-01

    As concern grows for maintaining and improving the quality of the environment and protecting human health, all the world is turning its attention to the potential environmental in pact of their industrial activities. One of the most important contribution in that way is the International Standard ISO 14000 series. In the utilization of nuclear energy, right from the inception, the safety of personnel, environment and the population has been the basic consideration. Over the years well established licenses criteria have been proposed to limit and control the environmental impact of the plant operation and emergencies situation. In this paper are discussed some specific requirements for implementation of the environmental management system specified by ISO 14000 compared to the environmental requirements for nuclear licensing. (author)

  12. Definition of a CDI metadata profile and its ISO 19139 based encoding

    Science.gov (United States)

    Boldrini, Enrico; de Korte, Arjen; Santoro, Mattia; Schaap, Dick M. A.; Nativi, Stefano; Manzella, Giuseppe

    2010-05-01

    The Common Data Index (CDI) is the middleware service adopted by SeaDataNet for discovery and query. The primary goal of the EU funded project SeaDataNet is to develop a system which provides transparent access to marine data sets and data products from 36 countries in and around Europe. The European context of SeaDataNet requires that the developed system complies with European Directive INSPIRE. In order to assure the required conformity a GI-cat based solution is proposed. GI-cat is a broker service able to mediate from different metadata sources and publish them through a consistent and unified interface. In this case GI-cat is used as a front end to the SeaDataNet portal publishing the original data, based on CDI v.1 XML schema, through an ISO 19139 application profile catalog interface (OGC CSW AP ISO). The choice of ISO 19139 is supported and driven by INSPIRE Implementing Rules, that have been used as a reference through the whole development process. A mapping from the CDI data model to the ISO 19139 was hence to be implemented in GI-cat and a first draft quickly developed, as both CDI v.1 and ISO 19139 happen to be XML implementations based on the same abstract data model (standard ISO 19115 - metadata about geographic information). This first draft mapping pointed out the CDI metadata model differences with respect to ISO 19115, as it was not possible to accommodate all the information contained in CDI v.1 into ISO 19139. Moreover some modifications were needed in order to reach INSPIRE compliance. The consequent work consisted in the definition of the CDI metadata model as a profile of ISO 19115. This included checking of all the metadata elements present in CDI and their cardinality. A comparison was made with respect to ISO 19115 and possible extensions were individuated. ISO 19139 was then chosen as a natural XML implementation of this new CDI metadata profile. The mapping and the profile definition processes were iteratively refined leading up to a

  13. BiBTeX styl pro ČSN ISO 690 a ČSN ISO 690-2

    OpenAIRE

    Pyšný, Radek

    2009-01-01

    Tato práce popisuje průběh vytváření bibliografického stylu pro nástroj BibTeX, pomocí něhož lze v LaTeXu sázet bibliografické citace v souladu s normou ČSN ISO 690. V úvodu práce je proveden rozbor ČSN ISO 690. Následuje popis spolupráce mezi systémem LaTeX a nástrojem BibTeX. Podstatná část práce je věnována popisu struktury souborů, které BibTeX potřebuje pro svou funkci, tj. bibliografická databáze a bibliografický styl. Závěr této práce je věnovaný popisu vlastností vytvořeného bibliogra...

  14. [ISO 9001-2000 certification for refractive laser treatment].

    Science.gov (United States)

    Lebuisson, D A; Arson, B; Abenhaïm, A; Albou-Ganem, C; Assouline, M; Chong Sit, D; Danan, A; Montefiore, G; Montin, J-F; Nguyen-Khoa, J-L; Pietrini, D; Saragoussi, J-J; Trong, Th; Amar, R

    2005-05-01

    To obtain ISO 9001-2000 certification for laser corneal refractive treatment, never before sought in Europe. The consulting firm Veritas led the certification process with the clinic's staff manager. This ISO norm is dedicated to the implementation of a quality management system. We assessed and optimized all necessary resources, evaluating customer satisfaction using patient and referring-physician surveys. We started quality rounds including surgeons, nurses, and technicians. Based on this preparation, we redefined and explained all processes including staff responsibilities and necessary resources in the quality manual. The procedure lasted 14 months with substantial involvement on the part of the management. Unconditional ISO 9001-2000 certification was granted by the independent audit firm, BVQI, in december 2003 for refractive laser treatment. The 2000 version of the new ISO 9001-2000 seeks to meet the demand for improving health care delivery in this field, most particularly by establishing a clear procedural orientation. Such certification enhances team work, stabilizes methodologies, and reinforces cohesion and self-audit. Patients notice that the center follows a consistent quality policy and are assured that the clinic respects rules and regulations. Certification is an advantageous alternative when accreditation cannot be considered. Our article discusses the steps taken in upper management, quality management, procedural guidance, as well as customer and staff counselling. It also discusses the project's cost/benefit ratio for the organization.

  15. English translations of German standards. Catalogue 1988. 24. ed.

    International Nuclear Information System (INIS)

    1988-01-01

    The catalogue contains a list of all currently available English translations of DIN standards, and of English translations of DIN handbooks, a numerical index, an alphabetical index, and an index of DIN EN, DIN IEC, DIN ISO standards, LN and VG standards. Some useful information on standards work in Germany and on the activities of DIN Deutsches Institut fuer Normung e.V. is given. (orig./HP)

  16. Framework for establishing records control in hospitals as an ISO 9001 requirement.

    Science.gov (United States)

    Al-Qatawneh, Lina

    2017-02-13

    Purpose The purpose of this paper is to present the process followed to control records in a Jordanian private community hospital as an ISO 9001:2008 standard requirement. Design/methodology/approach Under the hospital quality council's supervision, the quality management and development office staff were responsible for designing, planning and implementing the quality management system (QMS) using the ISO 9001:2008 standard. A policy for records control was established. An action plan for establishing the records control was developed and implemented. On completion, a coding system for records was specified to be used by hospital staff. Finally, an internal audit was performed to verify conformity to the ISO 9001:2008 standard requirements. Findings Successful certification by a neutral body ascertained that the hospital's QMS conformed to the ISO 9001:2008 requirements. A framework was developed that describes the records controlling process, which can be used by staff in any healthcare organization wanting to achieve ISO 9001:2008 accreditation. Originality/value Given the increased interest among healthcare organizations to achieve the ISO 9001 certification, the proposed framework for establishing records control is developed and is expected to be a valuable management tool to improve and sustain healthcare quality.

  17. Vocational High School Effectiveness Standard ISO 9001: 2008 for Achievement Content Standards, Standard Process and Competency Standards Graduates

    Directory of Open Access Journals (Sweden)

    Yeni Ratih Pratiwi

    2014-06-01

    Full Text Available Efektivitas Sekolah Menengah Kejuruan Berstandar ISO 9001:2008 terhadap Pencapaian Standar Isi, Standar Proses dan Standar Kompetensi Lulusan Abstract: The purpose of this study was to determine differences in the effectiveness of the achievement of the content standards, process standards, and competency standards in vocational already standard ISO 9001: 2008 with CMS that has not been standardized ISO 9001: 2008 both in public schools and private schools. Data collection using the questionnaire enclosed Likert scale models. Analysis of data using one-way ANOVA using SPSS. The results showed: (1 there is no difference in effectiveness between public SMK ISO standard ISO standards with private SMK (P = 0.001; (2 there are differences in the effectiveness of public SMK SMK ISO standards with ISO standards have not (P = 0.000; (3 there are differences in the effectiveness of public SMK ISO standards with private vocational yet ISO standards (P = 0.000; (4 there are differences in the effectiveness of the private vocational school with vocational standard ISO standard ISO country has not (P = 0.015; (5 there are differences in the effectiveness of the private vocational bertandar ISO with private vocational yet standardized ISO (P = 0.000; (6 there was no difference in the effectiveness of public SMK has not been standardized by the ISO standard ISO private SMK yet. Key Words: vocational high school standards ISO 9001: 2008, the standard content, process standards, competency standards Abstrak: Tujuan penelitian ini untuk mengetahui perbedaan efektivitas pencapaian standar isi, standar proses, dan standar kompetensi lulusan pada SMK yang sudah berstandar ISO 9001:2008 dengan SMK yang belum berstandar ISO 9001:2008 baik pada sekolah negeri maupun sekolah swasta. Pengumpulan data menggunakan kuisioner tertutup model skala likert. Analisis data menggunakan ANOVA one way menggunakan program SPSS. Hasil penelitian menunjukkan: (1 ada perbedaan

  18. Analysis of ISO 26262 Compliant Techniques for the Automotive Domain

    NARCIS (Netherlands)

    M. S. Kannan; Y. Dajsuren (Yanjindulam); Y. Luo; I. Barosan

    2015-01-01

    htmlabstractThe ISO 26262 standard denes functional safety for automotive E/E systems. Since the publication of the rst edition of this standard in 2011, many dierent safety techniques complying to the ISO 26262 have been developed. However, it is not clear which parts and (sub-) phases of the

  19. Analysis of ISO 26262 compliant techniques for the automotive domain

    NARCIS (Netherlands)

    S., Manoj Kannan; Dajsuren, Y.; Luo, Y.; Barosan, I.; Antkiewicz, M.; Atlee, J.; Dingel, J.; S, R.

    2015-01-01

    The ISO 26262 standard defines functional safety for automotive E/E systems. Since the publication of the first edition of this standard in 2011, many different safety techniques complying to the ISO 26262 have been developed. However, it is not clear which parts and (sub-) phases of the standard

  20. Diagnóstico da integração dos sistemas de gestão ISO 9001, ISO 14001 e OHSAS 18001

    Directory of Open Access Journals (Sweden)

    Samuel Vinícius Bonato

    2015-09-01

    Full Text Available Este artigo apresenta os resultados de uma pesquisa que teve por finalidade o diagnóstico do nível de integração de sistemas de gestão baseados nas normas ISO 9001, ISO 14001 e OHSAS 18001 em empresas do ramo metal-mecânico. Inicialmente foi descrito o método de diagnóstico e posteriormente realizada a sua aplicação em uma empresa já certificada nas três normas, mas que possui dois sistemas de gestão distintos: o Sistema de Gestão da Qualidade (SGQ baseado na norma ISO 9001 e o Sistema de Gestão de Saúde, Segurança e Meio Ambiente (SSM baseado nas normas ISO 14001 e OHSAS 18001. Entre os principais resultados, destaca-se a aceitação favorável do diagnóstico da integração na empresa estudada. Com a realização do diagnóstico, verificou-se que a organização não atende totalmente a integração de nenhum dos requisitos avaliados. Foram sugeridas oportunidades de melhoria para integração dos requisitos normativos comuns, reduzindo custos e recursos para manutenção do sistema de gestão da empresa.

  1. Discussion on the compilation of document of iso quality management system for radiation sterilization enterprises

    International Nuclear Information System (INIS)

    Li Chunhong; Ha Yiming; Zhou Hongjie; Feng Zhiguo; Wang Feng

    2006-01-01

    According to the character of cooperation of radiation sterilization, and association with request of ISO9001, ISO13485 and ISO11137, compilation of document in quality manual, procedure document and technological document during certification of ISO quality management system of cooperation of radiation sterilization was discussed. (authors)

  2. Interim Report on ISO TC 163 Working Group 3. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Fairey, Philip [Florida Solar Energy Center, Cocoa, FL (United States)

    2009-04-02

    This reports cover the initial year efforts of the International Standards Organization (ISO) to develop international standards for rating the energy performance of buildings. The author of this report is a participant in this effort. This report summarizes the activities of the ISO Working Group charged with development of these standards and makes recommendations to the sponsors for future U.S. involvement in this ISO effort.

  3. Progress report on the management of the NEA ISOE system

    Energy Technology Data Exchange (ETDEWEB)

    Lazo, E. [OECD Nuclear Energy Agency, Issy-les-Moulineaux (France)

    1995-03-01

    The Information System on Occupational Exposure (ISOE) was launched by the Organization for Economic Cooperation and Development (OECD), Nuclear Energy Agency (NEA) on 1 January, 1992, to facilitate the communication of dosimetric and ALARA implementation data among nuclear utilities around the world. After two years of operation the System has become a mature interactive network for transfer of data and experience. Currently, 37 utilities from 12 countries, representing 289 power plants, and 12 national regulatory authorities participate in ISOE. Agreements for cooperation also exist between the NEA and the Commission of the European Communities (CEC), and the Paris Center of the WOrld Association of Nuclear Operators (WANO-PC). In addition, the International Atomic Energy Agency (IAEA) is acting as a co-sponsor of ISOE for the participation of non-NEA member countries. Three Regional Technical Centres, Europe, Asia, and Non-NEA member countries, serve to administer the system. The ISOE Network is comprised of three data bases and a communications network at several levels. The three ISOE data bases include the following types of information: NEA1 - annual plant dosimetric information; NEA2 - plant operational characteristics for dose and dose rate reduction; and NEA3 - job specific ALARA practices and experiences. The ISOE communications network has matured greatly during 1992 and 1993. In addition to having access to the above mentioned data bases, participants may now solicit information on new subjects, through the Technical Centres, from all other participants on a real-time basis. Information Sheets on these studies are produced for distribution to all participants. In addition, Topical Reports on areas of interest are produced, and Topical Meetings are held annually.

  4. Progress report on the management of the NEA ISOE system

    International Nuclear Information System (INIS)

    Lazo, E.

    1995-01-01

    The Information System on Occupational Exposure (ISOE) was launched by the Organization for Economic Cooperation and Development (OECD), Nuclear Energy Agency (NEA) on 1 January, 1992, to facilitate the communication of dosimetric and ALARA implementation data among nuclear utilities around the world. After two years of operation the System has become a mature interactive network for transfer of data and experience. Currently, 37 utilities from 12 countries, representing 289 power plants, and 12 national regulatory authorities participate in ISOE. Agreements for cooperation also exist between the NEA and the Commission of the European Communities (CEC), and the Paris Center of the WOrld Association of Nuclear Operators (WANO-PC). In addition, the International Atomic Energy Agency (IAEA) is acting as a co-sponsor of ISOE for the participation of non-NEA member countries. Three Regional Technical Centres, Europe, Asia, and Non-NEA member countries, serve to administer the system. The ISOE Network is comprised of three data bases and a communications network at several levels. The three ISOE data bases include the following types of information: NEA1 - annual plant dosimetric information; NEA2 - plant operational characteristics for dose and dose rate reduction; and NEA3 - job specific ALARA practices and experiences. The ISOE communications network has matured greatly during 1992 and 1993. In addition to having access to the above mentioned data bases, participants may now solicit information on new subjects, through the Technical Centres, from all other participants on a real-time basis. Information Sheets on these studies are produced for distribution to all participants. In addition, Topical Reports on areas of interest are produced, and Topical Meetings are held annually

  5. ISO standardization in nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Brabec, D. (Ustav pro Vyzkum, Vyrobu a Vyuziti Radioisotopu, Prague (Czechoslovakia)); Cermak, O. (Urad pro Normalizaci a Mereni, Prague (Czechoslovakia))

    1984-10-01

    The activity is described of the technical commission ISO/TC 85 which is currently divided into 4 subcommissions (SC) and 24 working groups. SC 1 ''Terminology, definitions, units, abbreviations'' has one working group. The most important document of this SC is ISO 921-1972 (Dictionary of nuclear technology). SC 2 ''Radiation protection'' has 9 working groups and has processed standards in dosimetry. SC 3 ''Technology of power reactors'' has 6 working groups and its work is related to IAEA activities within the NUSS program. SC 4 ''Technology of nuclear fuels'' has 8 working groups. SC 4 has compiled the basic standards for sealed sources and methods of testing their tightness. The results of the work of this group have been reflected into the standardization work of CMEA. A list is given of published international standards within TC 85.

  6. IMPLEMENTASI ISO 9001: 2000 PADA PEMBELAJARAN PRODUKTIF BIDANG KEAHLIAN BANGUNAN DI SEKOLAH MENENGAH KEJURUAN

    Directory of Open Access Journals (Sweden)

    Riban Riban

    2012-08-01

    Full Text Available The implementation of ISO 9001: 2000 in productive learning of building engineering sector in vocational education. The objtective of this study was to uncover the barriers to implementation of ISO 9001:2000 in productive learning. The study was designed using multisite study design. Tecniques of collecting the data were interview, observation to partici­pants, and documentation test. The result of the study are: (1 Implementation of the ISO 9001: 2000 in productive learning of  building engineering sector relates to the implementation of the concept of P-D-C-A in the ISO quality management system; (2 the barriers in implementation of ISO 9001:2000 in pro­ductive learning include low awareness level, inconsistencies, and disobedience; and (3 efforts to overcome the barriers to implementation of ISO 9001:2000 in produc­tive learning involve building the shared commitment, socialization in order to create together awareness, supervising, and doing the preventive action. Implementasi ISO 9001: 2000 pada Pembelajaran Produktif Bidang Keahlian Bangunan di Sekolah Menengah Kejuruan. Penelitian ini bermaksud meng­ungkap lebih mendalam tentang, imple­men­­­tasi, hambatan-hambatan, dan upaya-upaya dalam mengatasi ham­batan penerap­an ISO 9001: 2000 pada pembelajaran produktif. Penelitian ini diran­cang dengan menggunakan rancangan studi multisitus. Teknik pengum­pulan data meliputi wawan­cara, observasi partisipan, dan studi dokumentasi. Temuan penelitian adalah: (1 Penerapan ISO 9001: 2000 pada pem­belajaran pro­duktif teknik bangunan mengacu pada konsep P-D-C-A ke dalam sistem manajemen mutu ISO; (2 hambatan implementasi ISO 9001: 2000 pada pem­bel­ajaran produktif meliputi tingkat kesadaran rendah, inkonsistensi, dan ketidak­taatasasan; dan (3 upaya mengatasi hambatan dalam implementasi ISO 9001: 2000 pada pembelajar­an produk­tif meliputi membangun komitmen bersama, sosialisasi dalam rangka me­num­buhkan kesadaran bersama

  7. ISO 26000 – An Integrative Approach of Corporate Social Responsibility

    Directory of Open Access Journals (Sweden)

    Herciu Mihaela

    2016-04-01

    Full Text Available ISO 26000 represents a guidance on corporate social responsibility and it is, at the present time, one of the most important document on CSR in the world. Without being mandatory or regulated, ISO 26000 is focus on seven core subjects that have to be approached synergistic – governance, human right, labor, environment, business practices, consumer, and community – in order to achieve its goal. The present paper intends to present and analyze the seven core subjects of ISO 26000 from tow perspectives: by emphasizing the benefits of implementing the standard into the business strategy and by revealing the correlation between corporate social responsibility and sustainable development.

  8. Age, colors and ISO standards

    NARCIS (Netherlands)

    Nes, van F.L.; Eschbach, R; Marcu, G.G.; Tominaga, S.; Rizzi, A.

    2010-01-01

    Age influences all bodily functions, also vision. Therefore, the effects of age on vision should be mirrored in ergonomic requirements laid down in display standards such as ISO 9241-300/307, 'Electronic visual display requirements'. However, this is only true to a limited extent - just as is the

  9. ISO 14001: time for improvements?

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg

    2007-01-01

    The aim of this paper is to discuss a number of issues related to ISO 14001:2004, the international standard for Environmental Management Systems (EMS) with the purpose of improving the next edition in order to recognise and reflect new recognitions in approaches to pollution prevention. A case...

  10. Specification of Energy Assessment Methodologies to Satisfy ISO 50001 Energy Management Standard

    Science.gov (United States)

    Kanneganti, Harish

    Energy management has become more crucial for industrial sector as a way to lower their cost of production and in reducing their carbon footprint. Environmental regulations also force the industrial sector to increase the efficiency of their energy usage. Hence industrial sector started relying on energy management consultancies for improvements in energy efficiency. With the development of ISO 50001 standard, the entire energy management took a new dimension involving top level management and getting their commitment on energy efficiency. One of the key requirements of ISO 50001 is to demonstrate continual improvement in their (industry) energy efficiency. The major aim of this work is to develop an energy assessment methodology and reporting format to tailor the needs of ISO 50001. The developed methodology integrates the energy reduction aspect of an energy assessment with the requirements of sections 4.4.3 (Energy Review) to 4.4.6 (Objectives, Targets and Action Plans) in ISO 50001 and thus helping the facilities in easy implementation of ISO 50001.

  11. Implementation of ISO 10110 optics drawing standards for the National Ignition Facility

    International Nuclear Information System (INIS)

    Aikens, D. M.; English, R. E.; Wang, D. Y.

    1999-01-01

    The National Ignition Facility (NIF) project elected to implement ISO 10110 standard for the specifications of NIF optics drawings in 1996. More than 7,000 NIF large optics and 20,000 NIF small optics will be manufactured based on ISO 10110 indications. ISO 10110 standard meets many of the needs of the NIF optics specifications. It allows the optical engineer to quantify and clearly communicate the desired optical specifications. While no single drawing standard specifies all the requirements of high energy laser system, a combination of ISO 10110 standard with detailed notes make it possible to apply international drawing standards to the NIF laser system. This paper will briefly describe LLNL's interpretation and implementation of the ISO 10110 drawing standard, present some examples of NIF optics drawings, and discuss pros and cons of the indications from the perspective of this application. Emphasis will be given to the surface imperfection specifications, known as 5/, for the NIF optics

  12. Implementation of ISO 10110 optics drawing standards for the National Ignition Facility

    Science.gov (United States)

    Wang, David Y.; English, R. Edward, Jr.; Aikens, David M.

    1999-11-01

    The National Ignition Facility (NIF) project elected to implement ISO 10110 standard for the specifications of NIF optics drawings in 1996. More than 7,000 NIF large optics and 20,000 NIF small optics will be manufactured based on ISO 10110 indications. ISO 10110 standard meets many of the needs of the NIF optics specifications. It allows the optical engineer to quantify and clearly communicate the desired optical specifications. While no single drawing standard specifies all the requirements of high energy laser system, a combination of ISO 10110 standard with detailed notes make it possible to apply international drawing standards to the NIF laser system. This paper will briefly describe LLNL's interpretation and implementation of the ISO 10110 drawing standard, present some examples of NIF optics drawings, and discuss pros and cons of the indications from the perspective of this application. Emphasis will be given to the surface imperfection specifications, known as 5/, for the NIF optics.

  13. Plasma 8-iso-Prostaglandin F2α, a possible prognostic marker in aneurysmal subarachnoid hemorrhage.

    Science.gov (United States)

    Pan, De-Sheng; Yan, Min; Hassan, Muhammad; Fang, Ze-Bin; Chen, Man-Tao

    2017-06-01

    8-iso-Prostaglandin F2α (8-iso-PGF2α) is a potential biomarker of oxidative stress. This study clarified whether plasma 8-iso-PGF2α concentrations were affected and its underlying relevance to prognosis in aneurysmal subarachnoid hemorrhage (aSAH). In this prospective, observational study, a total of 170 controls and 170 aSAH patients were enrolled. Plasma 8-iso-PGF2α concentrations were detected using an ELISA. Severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale. Clinical outcomes included 6-month mortality and poor outcome referred to as Glasgow outcome scale score of 1-3. As compared to controls, admission plasma 8-iso-PGF2α concentrations were significantly enhanced. Increased concentrations of plasma 8-iso-PGF2α correlated with WFNS scores and modified Fisher scores. 8-iso-PGF2α in plasma was an independent predictor for clinical outcomes. Under ROC curve, the predictive values of 8-iso-PGF2α concentrations resembled those of WFNS scores and modified Fisher scores for clinical outcomes. An elevation in plasma 8-iso-PGF2α concentrations is associated with the severity and poor outcome after aSAH, substantializing 8-iso-PGF2α as a potential prognostic biomarker of aSAH. Copyright © 2017. Published by Elsevier B.V.

  14. 75 FR 5779 - Notice Providing Agenda for Technical Conference on RTO/ISO Responsiveness

    Science.gov (United States)

    2010-02-04

    ... Conference on RTO/ISO Responsiveness January 27, 2010. California Independent System Operator Docket No. ER09.... Southwest Power Pool, Inc Docket Nos. ER09-1050-000, ER09- 1192-000. ISO New England, Inc. and New England.... Agenda--Technical Conference on RTO/ISO Responsiveness February 4, 2010 12:30 Panel 1--Stakeholder...

  15. ISO 9000 Series Certification Over Time: what have we learnt?

    NARCIS (Netherlands)

    A. van der Wiele (Ton); A.M. Brown (Alan)

    2002-01-01

    textabstractThe ISO 9000 experiences of the same sample of organisations over a five year time period is examined in this paper. The responses to a questionnaire sent out at the end of 1999 to companies which had a reasonably long term experience with the ISO 9000 series quality system are analysed.

  16. Quality standards: Comparison between IAEA 50-C/SG-Q and ISO 9001:2000

    International Nuclear Information System (INIS)

    2002-01-01

    The International Atomic Energy Agency (IAEA) has the statutory mandate to seek to accelerate and enlarge the contribution of atomic energy to peace, health and prosperity throughout the world. As part of the activities to achieve its objectives, the IAEA is authorized to establish standards of safety for the protection of health and the minimization of danger to life and property. The standards of safety developed by the IAEA are recommendations for use by its Member States in the framework of national regulations for the safe utilization of nuclear energy. Such standards should be considered as nuclear safety regulatory documents. The standards developed by the International Organization for Standardization (ISO) are complementary technical documents emphasizing industrial application and contractual aspects. Regarding the quality assurance topic, the IAEA developed the publication Safety Series No. 50-C/SG-Q, Quality Assurance for Safety in Nuclear Power Plants and other Nuclear Installations, which is mostly used directly or indirectly to establish the nuclear safety requirements at the nuclear utility-regulator interface. The ISO 9001:2000 standard, Quality Management Systems Requirements, is often used to define the quality management system requirements at the utility-supplier interface. The relationship between the IAEA and ISO quality standards is growing in significance owing to their increasing impact upon utilities (owners/operators of nuclear facilities) and their contractors/suppliers. The relationship between the IAEA and ISO standards is considered critical in particular with respect to contractors/suppliers with a small range of nuclear supplies. These contractors-suppliers are not always willing to prepare special quality assurance programmes based on nuclear safety standards. On the other hand, these contractors/suppliers may be qualified on the basis of the ISO quality standard. In any case, for delivering nuclear items and services the

  17. ISO 14001: implementar ou não? Uma proposta para a tomada de decisão ISO 14001: adopt it or not? A proposal for the decision making process

    Directory of Open Access Journals (Sweden)

    Giuliano Nacarato Moretti

    2008-12-01

    Full Text Available Entre as vantagens e desvantagens oferecidas pela implementação da norma ISO 14001, o empresário, muitas vezes, não encontra subsídios suficientes para a tomada de decisão pela adoção ou não da referida norma. Este trabalho apresenta uma ferramenta de auxílio à tomada de decisão empresarial, promovendo um estudo sobre a real necessidade e viabilidade da implementação da norma ISO 14001 e a respectiva certificação. Trata-se de uma análise multicriterial, em que se verifica a compatibilidade entre o perfil organizacional e a norma ISO 14001. Busca-se facilitar a decisão das organizações em adotar ou não a ISO 14001, por meio de uma recomendação que aumente sua probabilidade de atingir os objetivos almejados. A ferramenta demonstrou sua forte aplicabilidade quando implementada em duas empresas.One of the difficulties of the decision making process, is that many entrepreneurs may find themselves incapable of finding enough subsidies for the decision of adopting or not the ISO 14001 standard. This work presents a tool that facilitates corporate decision making, providing a thorough analysis of the real necessity and feasibility of the implementation of the ISO 14001 standard and its certification. This tool consists of a multicriterial analysis, in which is possible to verify the compatibility between the organizational profile and the ISO 14001 standard. This recommendation of adopting or not the ISO 14001 standard seeks to facilitate the organization decision making; and, as a result, it also enhances the probability of the organization attaining its objectives. This tool presented a strong applicability when implemented in two companies.

  18. PERBANDINGAN IMPLEMENTASI ISO DAN PELUNCURAN ENTERPRISE RESOURCES PLANNING TERHADAP INDEKS KINERJA KEUANGAN

    Directory of Open Access Journals (Sweden)

    Sautma Ronni Basana

    2017-03-01

    Full Text Available Recently, companies implemented projects which applied on companies’ overall system. These recent bestpractices of pursuing companies’ effectiveness and efficiency would be implementation of ISO 9000 and ERP.Previous research showed that these two projects could bring benefits for these companies which implementedit. However, it had not been compared which project would bring more benefits to these companies. Thisresearch observed 35 companies which consisted of 15 companies in food and beverages industry, 9 companiesin pharmaceutical industry, 4 companies in cigarettes industry, 4 companies in cosmetics industry, and 3companies in household appliances industry. The data were taken by observing and recording the valueswhich related to COGS (cost of goods sold, total inventory, net income, gross income, operating income, pretaxincome, cash flow operation, total liabilities, and total asset after ISO and ERP implementation. The resultsshowed that there was no significant difference of the ISO and ERP implementation on the factors of inventoryturnover, and weeks of supply. While the other factors showed significant differences between the implementationof ERP and ISO. Net profit margin, gross profit margin, and operating profit margin showed better resulton ERP launching. On the other hand, pretax margin showed better than ISO 9000 implementation. Overall,ERP implementation showed better results compared with ISO 9000.

  19. Iso-vector form factors of the delta and nucleon in QCD sum rules

    International Nuclear Information System (INIS)

    Ozpineci, A.

    2012-01-01

    Form factors are important non-perturbative properties of hadrons. They give information about the internal structure of the hadrons. In this work, iso-vector axial-vector and iso-vector tensor form factors of the nucleon and the iso-vector axial-vector Δ→N transition form factor calculations in QCD Sum Rules are presented.

  20. A search for PAHs in the ISO spectra of comet Hale-Bopp

    Science.gov (United States)

    Crovisier, J.; Bockelée-Morvan, D.

    2007-12-01

    From a new analysis of a spectrum of comet C/1995 O1 (Hale-Bopp) obtained with the Infrared Space Observatory (ISO), Lisse et al. (2007) claimed the identification of many new dust species. Among them are PAHs, which were not found in our first analysis of the ISO spectra. We present a re-examination of the ISO observations of comet Hale-Bopp, which does not confirm the conclusion of Lisse et al.

  1. U-value measurements on ISO round Robin window

    DEFF Research Database (Denmark)

    Duer, Karsten

    1997-01-01

    9 laboratories in 6 european and 2 north american countries have participated in a round robin U-value test of a standard facade window. The objective of the round robin test was to verify that the ISO/CEN proposals for U-value measurement standard is robust.......9 laboratories in 6 european and 2 north american countries have participated in a round robin U-value test of a standard facade window. The objective of the round robin test was to verify that the ISO/CEN proposals for U-value measurement standard is robust....

  2. The new ISO 6579-1: A real horizontal standard for detection of Salmonella, at last!

    Science.gov (United States)

    Mooijman, Kirsten A

    2018-05-01

    Up to 2016, three international standard methods existed for the detection of Salmonella spp. in food, animal feed and samples from the primary production stage: ISO 6785:2001 for milk and milk products, ISO 6579:2002 for (other) food and animal feed and Annex D of ISO 6579:2007 for samples from the primary production stage. In 2009, an ISO/CEN working group started with the revision of ISO 6579:2002 with two main aims: combining the three aforementioned standards in one document and improving the information in ISO 6579:2002. Additionally it was decided to split ISO 6579 into three parts, where part 1 describes the detection, part 2 the enumeration by mini-MPN (published in 2012) and part 3 the serotyping of Salmonella (published in 2014). This paper describes the experiments and choices made for improving the part on detection of Salmonella (ISO 6579-1). The final voting stage on (draft) ISO 6579-1 was finished by the end of December 2016, with a positive outcome. Finally, a real horizontal standard became available for detection of Salmonella in food, animal feed, environmental samples in the area of food production and food handling and in samples from the primary production stage in 2017. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation.

    Science.gov (United States)

    Park, Sun Young; Park, Se Jin; Park, Nan Jeong; Joo, Woo Hong; Lee, Sang-Joon; Choi, Young-Whan

    2013-10-25

    Schisandra chinensis is commonly used for food and as a traditional remedy for the treatment of neuronal disorders. However, it is unclear which component of S. chinensis is responsible for its neuropharmacological effects. To answer this question, we isolated α-iso-cubebene, a dibenzocyclooctadiene lignin, from S. chinensis and determined if it has any anti-neuroinflammatory and neuroprotective properties against amyloid β-induced neuroinflammation in microglia. Microglia that are stimulated by amyloid β increased their production of pro-inflammatory cytokines and chemokines, prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS) and the enzymatic activity of matrix metalloproteinase 9 (MMP-9). We found this was all inhibited by α-iso-cubebene. Consistent with these results, α-iso-cubebene inhibited the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2) and MMP-9 in amyloid β-stimulated microglia. Subsequent mechanistic studies revealed that α-iso-cubebene inhibited the phosphorylation and degradation of IκB-α, the phosphorylation and transactivity of NF-κB, and the phosphorylation of MAPK in amyloid β-stimulated microglia. These results suggest that α-iso-cubebene impairs the amyloid β-induced neuroinflammatory response of microglia by inhibiting the NF-κB and MAPK signaling pathways. Importantly, α-iso-cubebene can provide critical neuroprotection for primary cortical neurons against amyloid β-stimulated microglia-mediated neurotoxicity. To the best of our knowledge, this is the first report showing that α-iso-cubebene can provide neuroprotection against, and influence neuroinflammation triggered by, amyloid β activation of microglia. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  4. ISO sertifikaat aitab otsustada / Toomas Udu

    Index Scriptorium Estoniae

    Udu, Toomas

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti : Transport i logistika 25. mai lk. 8. Teenuse kvaliteedi näitajad logistikafirmas ISO standardi alusel. Vt. samas: Eestis kasutatakse kolme kvaliteedistandardit; Kuidas mõjutada kvaliteeti läbi juhtimissüsteemi

  5. Gaining competitive advantage in personal dosimetry services through ISO 9001 certification

    International Nuclear Information System (INIS)

    Noriah, M.A.

    2005-01-01

    Full text: In Malaysia, the harmonization of dose monitoring for almost 12,000 radiation workers is assigned to the Secondary Standard Dosimetry Laboratory of Malaysian Institute for Nuclear Technology Research, SSDL-MINT. Established in 1980, SSDL-MINT is responsible for improving personal and workplace safety by providing high quality personal dosimetry services. It is important to demonstrate that the performance of personal dosimetry meets recognized standards, to ensure radiation doses to individual workers are within the safe limits and to verify compliance with dose limits. Concern on the quality of personal dosimetry service began to be expressed in 2000. The concern led to the ISO certification, which brought an unprecedented effort characterized by high degree coordination, proper documentation and well trained of personal dosimetry operators. These huge efforts resulted with certification ISO 9002:1994 by the SIRIM International QAS Sdn. Bhd. in January 2002. The adoption of these requirements for the ISO 9002 standard makes routine handling of the process easier, and increases the reliability and effectiveness of the services. This helps to increase the quality and uniformity of personal dosimetry. The revision of the ISO 9002:1994 to ISO 9001:2000 necessitated SSDL-MINT revising its quality management system. The work began in middle 2002, and by May 2003, SSDL-MINT has been upgraded to ISO 9001:2000. Certification to the ISO 9001:2000 demonstrates our ability to consistency provide service that meets the requirements of the customer and the regulatory authority. These includes: improved consistency of service / product performance and therefore higher customer satisfaction levels; uniformity in work processes across organizations; simplified and more uniform structure for quality documents; improved customer perception of the organizations image, culture and performance; reduced number of product and process non-conformances; greater employee

  6. PYME y cooperativas ante el reto de la RSE: la nueva ISO 26000 (SMEs and cooperatives confront the challenge of CSR: the new ISO 26000

    Directory of Open Access Journals (Sweden)

    Juan Pablo Landa

    2012-05-01

    Full Text Available Corporate Social Responsibility is a central issue in modern business and a main factor of companies strategies for competitiveness in a global economy . The recent approval of ISO26000 shows this general tendency to introduce social and environmental principles in global governance and organizational behaviour in all kinds of firms, organizations and multinational corporations. This paper offers a critical approach to the effects of ISO 26000 in the small and medium companies, and cooperatives, too. This norm is not focussed on the particularities of this kind of companies and shows some problems when implementing it in SME & social economy organizations. The question which comes up is if there is a necessity to adapt the implementation of ISO 26000 to these particular firms: in which cases and to what limits. La Responsabilidad Social Corporativa es una cuestión central en la economía moderna, y un factor fundamental en las estrategias competitivas de las empresas, en el marco de una economía globalizada. La reciente aprobación de la norma ISO 26000 recoge la tendencia general de introducir principios sociales y medioambientales en el gobierno global y en la organización de todo tipo de empresas, organizaciones y corporaciones multinacionales. Este artículo ofrece un acercamiento crítico a los efectos de la norma ISO 26000 en las PYMEs y cooperativas. Esta norma no contempla las particularidades de este tipo de compañías, y muestra algunos problemas al implantarlas en PYMEs y organizaciones de la economía social. Se cuestiona la necesidad de adaptar la implementación de la norma ISO 26000 a este tipo de organizaciones, en qué casos, y con qué limites.DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2049865

  7. Occupational exposures at nuclear power plants. Twelfth annual report of the Isoe programme, 2002

    International Nuclear Information System (INIS)

    2004-01-01

    The Information System on Occupational Exposure (ISOE) was created by the OECD Nuclear Energy Agency in 1992 to promote and co-ordinate international co-operative undertakings in the area of worker protection at nuclear power plants. The ISOE Programme provides experts in occupational radiation protection with a forum for communication and exchange of experience. The ISOE databases enable the analysis of occupational exposure data from the 465 commercial nuclear power plants participating in the Programme (representing some 90 per cent of the world's total operating commercial reactors). The Twelfth Annual Report of the ISOE Programme summarises achievements made during 2002 and compares annual occupational exposure data. Principal developments in ISOE participating countries are also described. (author)

  8. ISO 50001 for US Commercial Buildings - Current Status and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jingjing; Sheaffer, Paul

    2017-12-01

    ''ISO 50001: 2011 Energy management systems – Requirements with guidance for use'' is a voluntary International Standard which provides organizations a proven framework to manage energy and continuously improve their energy performance. Implementing ISO 50001 in the commercial building sector has its unique opportunities and challenges in comparison with the industrial sector. The energy footprint of a portfolio of commercial buildings can be just as significant as a large industrial facility in comparison. There are many energy-saving opportunities in commercial buildings that can be addressed without capital investments, and the perceived risks for making energy improvements can be lower than in the industrial sector. In addition, the energy-consuming systems in commercial buildings are limited in types and have many similarities across buildings, which makes it much easier to standardize many ISO 50001 required processes, 5 procedures and documents to simplify implementation. There are also some sector-unique challenges, such as less familiar with ISO systems and the certification process. Another challenge arises from the complexity in some buildings’ ownership, tenancy, and O&M responsibilities. This whitepaper discusses these opportunities and issues in detail. The paper also recommends the characteristics of organizations in the commercial building sector that can benefit the most from adopting the ISO 50001 standard – namely the “suitable market”. Eight segments (education, food sales, retail, inpatient health care, hospitality, office buildings, laboratories and data centers) within the commercial building sector are highlighted.

  9. The ISO9000 standard in electrical research

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez-Ortiz, G.; Davila-Nunez, G.; Gonzalez-Sustaeta, J. [Inst. de Investigaciones Electricas, Cuernavaca (Mexico). Unidad de Sistemas Informaticos

    1999-11-01

    In this article, the main aspects that are considered important upon applying the ISO9000 standard [ISO 94] in a research institution, company, or group, are described. The 20 sections of the standard are discussed emphasizing the concepts and definitions that can be differently interpreted in the process of elaboration of a quality manual for a group devoted to research, than when they are applied in the elaboration of a manual for a factory that produces material goods. The exposed reasoning was used in the elaboration of the quality manual in the Information Systems Unit of the Electrical Research Institute in Mexico, and it is being used in the installation and operation of the quality system.

  10. Sustainable development induction in organizations: a convergence analysis of ISO standards management tools' parameters.

    Science.gov (United States)

    Merlin, Fabrício Kurman; Pereira, Vera Lúciaduarte do Valle; Pacheco, Waldemar

    2012-01-01

    Organizations are part of an environment in which they are pressured to meet society's demands and acting in a sustainable way. In an attempt to meet such demands, organizations make use of various management tools, among which, ISO standards are used. Although there are evidences of contributions provided by these standards, it is questionable whether its parameters converge for a possible induction for sustainable development in organizations. This work presents a theoretical study, designed on structuralism world view, descriptive and deductive method, which aims to analyze the convergence of management tools' parameters in ISO standards. In order to support the analysis, a generic framework for possible convergence was developed, based on systems approach, linking five ISO standards (ISO 9001, ISO 14001, OHSAS 18001, ISO 31000 and ISO 26000) with sustainable development and positioning them according to organization levels (strategic, tactical and operational). The structure was designed based on Brundtland report concept. The analysis was performed exploring the generic framework for possible convergence based on Nadler and Tushman model. The results found the standards can contribute to a possible sustainable development induction in organizations, as long as they meet certain minimum conditions related to its strategic alignment.

  11. KSC Center Director Bridges accepts an ISO 9001 certification plaque from DNV

    Science.gov (United States)

    1998-01-01

    Center Director Roy Bridges (right) displays the 2000th ISO Certificate Plaque he was given by Dalton Lyon (left) of Det Norske Veritas (DNV), Inc., an international ISO certification organization, at a ceremony at KSC. The plaque is a representation of the ISO 9001 certification awarded to KSC by DNV. ISO 9001 comprises the most detailed, comprehensive set of standard requirements for quality programs established by the International Standards Organization. The presentation followed a successful independent audit by DNV of the KSC Management System in May of this year. The third-party auditors examined about 20 elements of KSC's system, including management responsibility, design control, documentation, test and inspection, and corrective action procedures. DNV found that KSC met or exceeded the stringent quality standards in all areas. KSC will use this certification as a tool to improve an already world- class team. All NASA centers are required by NASA Administrator Daniel S. Goldin to be ISO 9001 registered by September 1999. NASA is the first federal agency to seek the quality certification.

  12. Step of quality assurance preparation on ISO 9001:2000 toward certification

    International Nuclear Information System (INIS)

    Agustiar

    2007-01-01

    ISO 9001:2000 is the International Standard for the quality management system that stipulate requirement and recommendation provided for design until product. The standard is also regulated the implementation and evaluation from management system point of view the objective to assure organization will meet specified requirement product. To propose ISO 9001:2000 certification, many steps of action should be carried out. There are 5 primary sections of the quality management system requirements of ISO 9001:2000. Quality Management system, Management responsibility, Resource management, Product realization and Measurement, Analysis and improvement, in which all will be begun with training until evaluation (author)

  13. Predicting the quantifiable impacts of ISO 50001 on climate change mitigation

    Energy Technology Data Exchange (ETDEWEB)

    McKane, Aimee; Therkelsen, Peter; Scodel, Anna; Rao, Prakash; Aghajanzadeh, Arian; Hirzel, Simon; Zhang, Ruiqin; Prem, Richard; Fossa, Alberto; Lazarevska, Ana M.; Matteini, Marco; Schreck, Bettina; Allard, Fabian; Villegal Alcántar, Noé; Steyn, Karel; Hürdoğan, Ertaç; Björkman, Thomas; O' Sullivan, John

    2017-08-01

    The ISO 50001-Energy management standard provides a continual improvement framework for organizations to reduce their energy consumption, which in the industrial and commercial (service) sectors, accounts for nearly 40% of global greenhouse gas emissions. Reducing this energy consumption will be critical for countries to achieve their national greenhouse gas reduction commitments. Several national policies already support ISO 50001; however, there is no transparent, consistent process to estimate the potential impacts of its implementation. This paper presents the ISO 50001 Impacts Methodology, an internationally-developed methodology to calculate these impacts at a national, regional, or global scale suitable for use by policymakers. The recently-formed ISO 50001 Global Impacts Research Network provides a forum for policymakers to refine and encourage use of the methodology. Using this methodology, a scenario with 50% of projected global industrial and service sector energy consumption under ISO 50001 management by 2030 would generate cumulative primary energy savings of approximately 105 EJ, cost savings of nearly US $700 billion (discounted to 2016 net present value), and 6500 million metric tons (Mt) of avoided CO2 emissions. The avoided annual CO2 emissions in 2030 alone are equivalent to removing 210 million passenger vehicles from the road.

  14. The Role of ISO 9000 Certification on Waste Management of Leather Industry

    International Nuclear Information System (INIS)

    Susetyo Hario Putero; Dhani Astuti

    2008-01-01

    State of industry in an area could increase economy of this area. On the other hand, industry may be produce the waste. There are many factor influencing the success of industrial waste management. At present, ISO 14000 is known as an international environmental management standard. Practically, several matter required for ISO 14000 are similar with ISO 9000. So, the role of ISO 9000 certification on supporting waste management program of leather industry has been studied. Study has been pursued by comparing the environmental management systems of 2 leather industries in Sitimulyo, Piyungan, Bantul. Staff working way has been observed to know the suitability with working procedures and implementation of safety aspect on daily working. Observation of waste treatment facility and measurement of Chrome concentration also has been done. Samples were analysed using AAS method in Department of Chemistry, Faculty of Mathematics and Natural Science, Gadjah Mada University. Decontamination Factor (DF) was calculated by comparing the Chrome concentrations on outside plant and in waste treatment facility. Commitment of management and orderliness of system as required on ISO 9000 certification could push the industry to well execute waste management program as a part of environmental management system. ISO 9000 certification is convinced to make awareness of industry grow for continually improving their capability, including their capacity of waste treatment facility. (author)

  15. Nanotechnology Standardization Activities – Support of U.S. Representation on ISO/TC 229 Nanotechnologies

    Energy Technology Data Exchange (ETDEWEB)

    Benko, Heather [American National Standards Inst. (ANSI), Washington, DC (United States)

    2017-03-14

    In carrying out its responsibilities on behalf of the United States, ANSI provides comprehensive, administrative support and expertise on international protocols and procedures to: (1) the U.S. Technical Advisory Group (TAG) to the International Organization for Standardization’s (ISO) Technical Committee (TC) 229 Nanotechnologies, and (2) the corresponding U.S. TAG Working Groups tasked with formulating U.S. positions on topics relevant to nanotechnology standardization. Additionally, secretariat and procedural support is provided for the ISO/TC 229 WG 3 on health, safety and environment, for which the United States was assigned leadership by the participating national body members of ISO/TC 229. As the official entity that serves as the U.S. representative to ISO, ANSI provides not only expert coordination of U.S. positions and representation at ISO but also strategic direction, advice and procedural expertise to facilitate navigation of international issues to promote U.S. positions for incorporation into the ISO/TC 229 program of work necessary to support U.S. objectives.

  16. Blood and urine 8-iso-PGF2α levels in babies of different gestational ages.

    Science.gov (United States)

    Li, Sitao; Hao, Hu; Zhou, Ping; Gao, Ping Ming; Xiao, Xin

    2014-01-01

    We measured cord blood and urine 8-iso-prostaglandin F2α (8-iso-PGF2α) levels in babies of different gestational ages to determine lipid peroxidation status. Babies at gestational ages of 28-43 weeks were divided into group A (28-32 weeks), group B (33-36 weeks), group C (37-41 weeks), and group D (42-43 weeks). 8-iso-PGF2α in umbilical cord blood (UCB) at birth and urine at 6 hours after birth was and tested by ELISA. UCB and urine 8-iso-PGF2α levels in group C were 130.09 ± 31.73 pg/ml and 27.14 ± 6.73 pg/ml, respectively. UCB 8-iso-PGF2α levels in group A and B were 188.42 ± 59.34 pg/ml and 189.37 ± 68.46 pg/ml, and urine 8-iso-PGF2α were 32.14 ± 7.32 pg/ml and 30.46 ± 8.83 pg/ml, respectively. Blood and urine 8-iso-PGF2α levels in group D (post-term) were 252.01 ± 46.42 pg/ml and 44.00 ± 8.50 pg/ml. For all babies, UCB and urine iso-PGF2α levels were significantly correlated (r = 0.65, P iso-PGF2α levels in normal full-term babies. Urine 8-iso-PGF2α levels may reflect the extent of lipid peroxidation in babies. In pre-term and post-term babies, there was evidence for increased lipid peroxidation.

  17. Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows.

    Science.gov (United States)

    Schwartz-Zimmermann, Heidi E; Hametner, Christian; Nagl, Veronika; Fiby, Iris; Macheiner, Lukas; Winkler, Janine; Dänicke, Sven; Clark, Erica; Pestka, James J; Berthiller, Franz

    2017-12-01

    The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent. So far, only DON-3-glucuronide (DON-3-GlcAc) and DON-15-GlcAc have been unequivocally identified as mammalian DON glucuronides, and DON-7-GlcAc has been proposed as further DON metabolite. In the present work, qualitative HPLC-MS/MS analysis of urine samples of animals treated with DON (rats: 2 mg/kg bw, single bolus, gavage; mice: 1 mg/kg bw, single i.p. injection; pigs: 74 µg/kg bw, single bolus, gavage; cows: 5.2 mg DON/kg dry mass, oral for 13 weeks) revealed additional DON and deepoxy-DON (DOM) glucuronides. To elucidate their structures, DON and DOM were incubated with human (HLM) and rat liver microsomes (RLM). Besides the expected DON/DOM-3- and 15-GlcAc, minor amounts of four DON- and four DOM glucuronides were formed. Isolation and enzymatic hydrolysis of four of these compounds yielded iso-DON and iso-DOM, the identities of which were eventually confirmed by NMR. Incubation of iso-DON and iso-DOM with RLM and HLM yielded two main glucuronides for each parent compound, which were isolated and identified as iso-DON/DOM-3-GlcAc and iso-DON/DOM-8-GlcAc by NMR. Iso-DON-3-GlcAc, most likely misidentified as DON-7-GlcAc in the literature, proved to be a major DON metabolite in rats and a minor metabolite in pigs. In addition, iso-DON-8-GlcAc turned out to be one of the major DON metabolites in mice. DOM-3-GlcAc was the dominant DON metabolite in urine of cows and an important DON metabolite in rat urine. Iso-DOM-3-GlcAc was detected in urine of DON-treated rats and cows. Finally, DON-8,15-hemiketal-8-glucuronide, a previously described by-product of DON-3-GlcAc production by RLM, was identified in urine of DON-exposed mice and rats. The discovery of several novel DON-derived glucuronides in animal urine requires adaptation of

  18. Beneficios de la aplicación de normas internacionales ISO en procesos electorales

    Directory of Open Access Journals (Sweden)

    Jeffrey Badí Quinteros Basantes

    2017-01-01

    Full Text Available En este artículo se presentarán los beneficios de la aplicabilidad de las normas internacionales ISO en los procesos electorales, con el fin de poder elevar los niveles de percepción positiva de los ciudadanos. Se verificará la aplicación de normas ISO/TS 17582:2014, Sistemas de Gestión de la Calidad y la norma ISO/IEC 27001:2013, para todas las fases de un proceso electoral. Se expondrán los dominios que forman parte de la norma ISO/TS 17582:2014 , los cuales permiten un proceso de mejoramiento continuo a fin de garantizar la calidad de las metodologías que soportan la organización, administración, gestión, seguimiento y auditorías de un proceso electoral. La norma ISO/IEC 27001:2013 se alinea con la norma ISO9001:2008 para la gestión de seguridad de la información. La aplicación de esta normativa permitirá asegurar la integridad, confidencialidad y disponibilidad de la información durante los procesos electorales.

  19. An iso-erodent map Imo state of Nigeria | Madubuike | International ...

    African Journals Online (AJOL)

    Among inputs/resources often needed for erosion risk assessment of a region is the iso-erodent map of the region. This is a map showing areas of equal erosion potentials in the region. As Imo and Abia states of Nigeria lie in a high erosion region of the country, it was decided in this work to produce an iso-erodent map of ...

  20. Programación de las normas ISO 12217-1 (2011) e ISO 12217-3 (2011) para el estudio de la estabilidad y flotabilidad de embarcaciones de recreo

    OpenAIRE

    Gallardo Martínez, Antonio

    2013-01-01

    Las embarcaciones de recreo para operar dentro de la Comunidad Europea deben de obtener el marcado CE. Para ello se evalúa y clasifica su estabilidad y flotabilidad según la normativa ISO 12217 y se asigna una categoría de diseño (A, B, C o D) adecuada a su diseño y a su carga total máxima. El presente proyecto tiene como objetivo la programación de las normas ISO 12217-1 referente a embarcaciones no propulsadas a vela de eslora igual o superior a 6 m y la norma ISO 12217-3 ...

  1. EPA STANDARDS NETWORK FACT SHEET: ISO 14000: INTERNATIONAL ENVIRONMENTAL MANAGEMENT STANDARDS

    Science.gov (United States)

    This flyer provides an overview of the ISO 14000 series of International standards, supplying a brief history, structure of the Technical Committee (TC) 207, structure of the U.S. Technical Advisory Group (TAG) to ISO TC-207, status of the Standards development as of June 1997, w...

  2. PENGARUH CSR BERDASAR ISO 26000 TERHADAP NILAI PERUSAHAAN DENGAN KARAKTERSITIK PERUSAHAAN SEBAGAI VARIABEL MODERATING

    Directory of Open Access Journals (Sweden)

    Sri Wahjuni Latifah

    2015-01-01

    Full Text Available Research of the influence of ISO 26000 CSR toward the company’s value as a moderating variable which is done on companies listed in Indonesia Stock Exchange. The Company’s characteristics are measured by firm age, size, leverage and profitability. The data analysis was done by using double linear regression models, the first is to see the effect based on the ISO 26000 CSR and firm characteristics on value, and the second is to see the effect of interaction with the ISO 26000 corporate characteristics. The results of the study showed that there was no influence of ISO 26000, the characteristics of the company toward the value of the company. However, moderated ISO 26000 by firm characteristics affect the value of the company.

  3. Providing for transmission in times of scarcity: an ISO cannot do it all

    International Nuclear Information System (INIS)

    Allen, E.; Ilic, M.; Younes, Z.

    1999-01-01

    The main purpose of this paper is to point out issues critical for establishing a good transmission strategy in an energy market. First, it is suggested that a transmission strategy must be discussed in the context of a specific market structure. Responsibilities of a transmission system provider differ fundamentally, depending on the type of energy market it is supposed to serve. To show this, a summary of information assumed to be known to an Independent System Operator (ISO) in three energy market structures is given, i.e., (1) a mandatory ISO, (2) an entirely multilateral market and (3) a voluntary ISO. The differences between these three proposals concerning an ISO's responsibility for achieving systemwide efficiency and fair charges for transmission service, particularly at times of scarcity, are analyzed. It is shown that an ISO equipped with the present types of optimization tools for both reliability and efficiency is generally 'blind' to questions of fairness with respect to the individual market participants when providing transmission system support. In order to get around this problem, much more work will have to he done by the technical and regulatory communities. The only tools at an ISO's disposal at present are used for systemwide objectives, such as systemwide reliability. While some of this work is under way, it will take some time to develop the actual ISO tools necessary for implementing the fairness criterion metrics ('standards'), whichever ones the community arrives at. (Developing metrics of fair reliability contributions for the individual market participants is a nonunique process, and it may be very difficult to actually agree upon). Meanwhile, in order to have an ISO actively help energy markets in a fair and efficient way in realistic markets, which are likely to be voluntary ISOs, a system user must become an active part of decision making, indicating how much it wishes to use the system at times of scarcity and at which price. One

  4. ISO-PC Version 1.98: User`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Rittmann, P.D.

    1995-05-02

    This document describes how to use Version 1.98 of the shielding program named ISO-PC. Version 1.98 corrects all known errors in ISOSHLD-II. In addition, a few numeric problems have been eliminated. There are three new namelist variables, 25 additional shielding materials, and 5 more energy groups. The two major differences with the original ISOSHLD-II are the removal of RIBD(radioisotope buildup and decay) source generator, and the removal of the non-uniform source distribution parameter, SSV1. This version of ISO-PC works with photon energies from 10 KeV to 10 MeV using 30 energy groups.

  5. Comparative advantage: the impact of ISO 14001 environmental certification on exports.

    Science.gov (United States)

    Bellesi, Florencia; Lehrer, David; Tal, Alon

    2005-04-01

    Relative to the enormous acceptance of the ISO 9000 quality standard, the ISO 14001 environmental management certification has been met with only moderate enthusiasm among industrial facilities. The literature on corporate motivation for ISO 14001 participation is relatively modest considering the enormous number of publications reviewing other aspects of its adoption and implementation. It would seem that the present "marketing" package supporting ISO environmental commitments does not seem to offer sufficiently persuasive incentives for increased sales, either domestically or internationally. While researchers assume that a higher export rate of companies is positively associated with higher ISO participation rates, there have been very few empirical studies that support this inference, and conclusions have not been based on data taken from importing countries orfrom a systematic evaluation of expressed corporate preference for products sold by ISO 14001 certified companies. The present study reports the results of a survey to firms in six countries that are Israel's leading trade partners, importing chemicals, textiles, and produce. The survey results confirm that while the international market still considers price and quality as the paramount factors in selection of suppliers, environmental management systems (EMS) are an important feature that is frequently taken into consideration. EMS certification appears to signify a supplier who is managing the business well and exhibiting ethical responsibility. The European market proved to be more environmentally conscious than those in other industrialized parts of the world. EMS offer a particularly valuable advantage for producers wishing to reach European markets. As policy-makers seek to expand the voluntary adoption of EMS, a clear advantage for exporters should be highlighted among national industries.

  6. IMPLEMENTASI QUALITY MANAGEMENT SYSTEM ISO 9001:2008 DALAM PEMBELAJARAN PRODUKTIF KEAHLIAN TEKNIK MESIN DAN OTOMOTIF SMK

    Directory of Open Access Journals (Sweden)

    Mochammad Ariful Ulfi

    2013-07-01

    Full Text Available The implementation of ISO 9001:2008 quality management system in the productive learning on the mechanical engineering and automotive in vocational high school. This research uses qualitative approach in term of a case study. The research is conducted at SMKN I Purwosari. The results of this research show that (1 the reason of the ISO imple­mentation is to obtain community trust, to improve compe­titiveness, and to increase the quality of the graduates; (2 the implementation of the quality management system in the learning process refers to the concept of PDCA of the ISO system; (3 the obstacles occured during the implementation of ISO is due to the lack of teachers’ awareness on the ISO system; and (4 some efforts to overcome those obstacles include developing commitment among all elements, socialization, supervision, and doing some preventive efforts. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus. Penelitian dilaksanakan di SMK Negeri 1 Purwosari. Adapun fokus penelitian adalah alasan penerapan ISO, implementasi dalam pembelajaran, hambatan, dan upaya mengatasi hambatan pelaksanaan ISO 9001:2008. Hasil penelitian menunjukkan   (1 alasan penerapan ISO adalah agar sekolah dipercaya masyarakat, meningkatkan daya saing, dan mening­kat­kan mutu lulusan; (2 implementasi dalam pembelajaran mengacu  pada konsep PDCA ke dalam sistem manajemen mutu ISO; (3 hambat­an implementasi ISO adalah tingkat kesadaran guru terhadap ISO yang rendah; (4 upaya mengatasi hambatan adalah membangun komitmen bersama, sosiali­sasi, supervisi, dan melakukan usaha pencegahan.

  7. Organizational leadership: A study on the affects of certification to International Organization for Standardization (ISO)

    Science.gov (United States)

    Cowart, Jewel S.

    Compliance to requirements of ISO is an important leadership problem for the International Aerospace Quality Group (IAQG) and the Aviation, Space and Defense (AS&D) companies. Furthermore, the IAQG seeks to understand the valuation of ISO/AS9100 requirements (2009), audit practices, management functions, business performance, customer satisfaction, and potential future concepts for the standard to assure quality. Since the release of the AS9100C total certification growth surpassed 1,100,000 organizations in 2010 with ISO 9001 series adoption and implementation governing business operations (ASQ, 2012b; ISO, 2011; Bernardo, Llach, & Marimon, 2011). Historians such as Crosby, Juran, Deming, and others established the foundation for quality assurance. Several researchers explored the issues which complicate overall benefits of ISO certification (Iwaro & Mwasha, 2012; Karthi et al., 2012; Sampaio et al., 2009). This study examined the effects on AS&D industries from ISO compliance to identify the implications (of ever-changing requirements) through an online survey of 15,000 practitioners. The research illuminated how ISO affects AS&D industries with current and future requirements for certification. The data showed that 75% of survey respondents report implementation of the AS9100C requirements still has benefits that outweigh the cost. Findings suggest that AS&D industries perceive significant value in the AS9100C document as part of the overall ISO 9000 series. In general, the comments from the survey can provide insight into the affects of ISO certification. The study concludes by recommending continued research to learn of further impacts from ISO certification within AS&D industries to improve the AS9100 document requirements for quality management systems.

  8. ISO 15189 Accreditation: Navigation Between Quality Management and Patient Safety

    Directory of Open Access Journals (Sweden)

    Plebani Mario

    2017-09-01

    Full Text Available Accreditation is a valuable resource for clinical laboratories and the development of an International Standard for their accreditation represented a milestone on the path towards improved quality and safety in laboratory medicine. The recent revision of the International Standard, ISO 15189, has further strengthened its value not only for improving the quality system of a clinical laboratory but also for better answering the request for competence, focus on customers’ needs and ultimate value of laboratory services. Although in some countries more general standards such as ISO 9001 for quality systems or ISO 17025 for testing laboratories are still used, there is increasing recognition of the value of ISO 15189 as the most appropriate and useful standard for the accreditation of medical laboratories. In fact, only this International Standard recognizes the importance of all steps of the total testing process, namely extra-analytical phases, the need to focus on technical competence in addition to quality systems, and the focus on customers’ needs. However, the number of accredited laboratories largely varies between European countries and also major differences affect the approaches to accreditation promoted by the national bodies. In particular, some national accreditation bodies perpetuate the use of fixed scopes, while the European co-operation for accreditation (EA and the European Federation of Laboratory Medicine (EFLM Working Group promote the use of flexible scopes. Major issues in clinical laboratory accreditation are the verification of examination procedures for imprecision, trueness and diagnostic accuracy and for estimating measurement uncertainty. In addition, quality indicators (QIs are a fundamental requirement of the ISO 15189 International Standard.

  9. Incorporating an ISO 8583-Service into an Unreliable Application

    OpenAIRE

    Funcke, Alexander

    2008-01-01

    If an existing service is to be made available to a broader audience, via for instance the Internet. The implementation of the service may thereby get many new requirements, such as support for a different access method or stricter authorisation and security policies. This thesis discusses the implementation of an ISO 8583 to XML proxy. ISO 8583 is a widely used financial protocol, and was in this project used to communicate with the backing financial server in order to implement a complete w...

  10. Evaluation of ISO EN 13606 as a result of its implementation in XML.

    Science.gov (United States)

    Austin, Tony; Sun, Shanghua; Hassan, Taher; Kalra, Dipak

    2013-12-01

    The five parts of the ISO EN 13606 standard define a means by which health-care records can be exchanged between computer systems. Starting within the European standardisation process, it has now become internationally ratified in ISO. However, ISO standards do not require that a reference implementation be provided, and in order for ISO EN 13606 to deliver the expected benefits, it must be provided not as a document, but as an operational system that is not vendor specific. This article describes the evolution of an Extensible Markup Language (XML) Schema through three iterations, each of which emphasised one particular approach to delivering an executable equivalent to the printed standard. Developing these operational versions and incorporating feedback from users of these demonstrated where implementation compromises were needed and exposed defects in the standard. These are discussed herein. They may require a future technical revision to ISO EN 13606 to resolve the issues identified.

  11. Approaches to the ISO/IEC 17025 accreditation for Pu and U accountancy analysis

    International Nuclear Information System (INIS)

    Okazaki, Hiro; Sumi, Mika; Abe, Katsuo; Sato, Mitsuhiro; Kageyama, Tomio

    2013-01-01

    The quality control section of Plutonium Fuel Development Center (PFDC) of Japan Atomic Energy Agency has been analyzing isotopic compositions by Mass Spectrometry as well as content by Isotope Dilution Mass Spectrometry (IDMS) of plutonium and uranium in nuclear materials. Along with establishing and managing the quality assurance system, ensuring the reliability of the analysis data is important. PFDC has been establishing the quality management system with ISO9001. ISO9001 consists of management requirements for quality system of organizations. While ISO/IEC 17025 consists of technical requirements for the competence of testing and calibration laboratories in addition to the management requirements. The quality control section addressed technical improvement to improve further reliability of analysis quality and we have accredited for ISO/IEC 17025 of isotopic compositions and content of plutonium and uranium in nuclear materials in March 2010. In this presentation, we report our approaches to the ISO/IEC 17025 accreditation and operation status. (author)

  12. Evaluation of ISO EN 13606 as a result of its implementation in XML

    Science.gov (United States)

    Sun, Shanghua; Hassan, Taher; Kalra, Dipak

    2013-01-01

    The five parts of the ISO EN 13606 standard define a means by which health-care records can be exchanged between computer systems. Starting within the European standardisation process, it has now become internationally ratified in ISO. However, ISO standards do not require that a reference implementation be provided, and in order for ISO EN 13606 to deliver the expected benefits, it must be provided not as a document, but as an operational system that is not vendor specific. This article describes the evolution of an Extensible Markup Language (XML) Schema through three iterations, each of which emphasised one particular approach to delivering an executable equivalent to the printed standard. Developing these operational versions and incorporating feedback from users of these demonstrated where implementation compromises were needed and exposed defects in the standard. These are discussed herein. They may require a future technical revision to ISO EN 13606 to resolve the issues identified. PMID:23995217

  13. Iso-scaling in a microcanonical multifragmentation model

    International Nuclear Information System (INIS)

    Raduta, R.; Raduta, H.

    2003-01-01

    A microcanonical multifragmentation model is used to investigate iso-scaling over a broad range of excitation energies, for several values of freeze-out volume and equilibrated sources with masses between 40 and 200 in both primary and asymptotic stages of the decay. It was found that the values of the slope parameters α and β depend on the size and excitation energy of the source and are affected by the secondary decay of primary fragments. It was evidenced that iso-scaling is affected by finite size effects. The evolution of the differences of neutron and proton chemical potentials corresponding to two equilibrated nuclear sources having the same size and different isospin values with temperature and freeze-out volume is presented. (authors)

  14. Incorporating ISO Metadata Using HDF Product Designer

    Science.gov (United States)

    Jelenak, Aleksandar; Kozimor, John; Habermann, Ted

    2016-01-01

    The need to store in HDF5 files increasing amounts of metadata of various complexity is greatly overcoming the capabilities of the Earth science metadata conventions currently in use. Data producers until now did not have much choice but to come up with ad hoc solutions to this challenge. Such solutions, in turn, pose a wide range of issues for data managers, distributors, and, ultimately, data users. The HDF Group is experimenting on a novel approach of using ISO 19115 metadata objects as a catch-all container for all the metadata that cannot be fitted into the current Earth science data conventions. This presentation will showcase how the HDF Product Designer software can be utilized to help data producers include various ISO metadata objects in their products.

  15. Integration of distributed plant lifecycle data using ISO 15926 and Web services

    International Nuclear Information System (INIS)

    Kim, Byung Chul; Teijgeler, Hans; Mun, Duhwan; Han, Soonhung

    2011-01-01

    Highlights: → The ISO 15926 parts that provide implementation methods are under development. → A prototype of an ISO 15926-based data repository called a facade was implemented. → The prototype facade has the advantages of data interoperability and integration. → These are obtained through the features of ISO 15926 and Web services. - Abstract: Considering the financial, safety, and environmental risks related to industrial installations, it is of paramount importance that all relevant lifecycle information is readily available. Parts of this lifecycle information are stored in a plethora of computer systems, often scattered around the world and in many native formats and languages. These parts can create a complete, holistic set of lifecycle data only when they are integrated together. At present, no software is available that can integrate these parts into one coherent, distributed, and up-to-date set. The ISO 15926 standard has been developed, and in part is still under development, to overcome this problem. In this paper, the authors discuss a prototype of an ISO 15926-based data repository called a facade, and its Web services are implemented for storing the equipment data of a nuclear power plant and servicing the data to interested organizations. This prototype is for a proof-of-concept study regarding the ISO 15926 parts that are currently under development and that are expected to provide implementation methods for the integration of distributed plant systems.

  16. ISOE: an international occupational exposure database and communications network for dose optimisation

    International Nuclear Information System (INIS)

    Robinson, I.F.; Lazo, E.

    1995-01-01

    The Information System on Occupational Exposure (ISOE) was launched by the Nuclear Energy Agency (NEA) of the Organisation for Economic Co-operation and Development (OECD) on 1 January 1992 to facilitate the communication of dosimetry and ALARA implementation data among nuclear facilities around the world. Members of ISOE include 51 utilities from 17 countries and regulators from 11 countries, with four regional technical centres administering the system and a Steering Group which manages the work. ISOE includes three databases and a communications network at several levels. The three databases NEA1, NEA2 and NEA3 include varying levels of details, with NEA3 being the most detailed giving task and site specific ALARA practices and experiences. Utility membership of ISOE gives full access to the databases whereas regulators have more limited access. This paper reviews the current status of participation, describes the three databases and the communications network. Some dose data showing trends in particular countries are presented as well as dose data relating to operation cycle length and outage length. The advantages of membership are described, and it is concluded that ISOE holds the potential for both dose and cost savings. (author)

  17. ISO: international standards development for nuclear technology

    International Nuclear Information System (INIS)

    Becker, K.

    1981-01-01

    The importance of internationally recognized standards for nuclear technology and safety is rapidly increasing for technical as well as economical and political reasons such as public acceptance and nuclear technology transfer to developing countries. The need for such standards is also evident because of the large number of nuclear installations sited close to international borders, and the export of nuclear installations from relatively few supplier countries to a large number of user countries. It is the purpose of this report to describe briefly the history, organizational structures and procedures, goals, accomplishments, problems, and future needs of the relevant activities of the International Organization for Standardization (ISO). ISO is composed of the partly governmental, partly non-governmental national standards bodies of 86 countries including China. The work of its Technical Committee (TC) 85 'Nuclear Energy' is mostly concerned with industrial applications, contractual aspects and international communication, for the benefit of both developed and developing countries. It works in close liaison with IAEA, which develops Codes and Guides addressed mainly to the regulatory aspects of nuclear power plants in developing countries. ISO/TC 85 has four sub-committees dealing with: (a) Terminology, Definitions, Units and Symbols (Secretariat USA, four working groups (WGs)); (b) Radiation Protection (Secretariat France, ten WGs); (c) Power Reactor Technology (Secretariat Sweden, nine WGs); (d) Nuclear Fuel Technology (Secretariat F.R. Germany, seven WGs). (author)

  18. ISO training program mixes lectures, hands-on exercises

    International Nuclear Information System (INIS)

    Sakofsky, S.; Vitale, D.

    1994-01-01

    Early in 1990, the Dresser-Rand Co., made the decision to upgrade its purchased material quality program and pursue ISO 9000 registration for all product divisions. A joint quality-purchasing council from all US based divisions met and developed a new strategy that included: developing and maintaining a common external audit schedule eliminating duplicate audits; development of a formal training program for auditors; implementing a rule for all divisions that called for internal and external audits to be conducted by certified auditors; implementing an aggressive internal audit program for each division preparing for ISO 9001 or 9002 registration. Development of a formal training program began with educating and training future instructors. Two people were selected who had previous audit and quality system experience. Both were sent to various seminars on ISO 9000, attended a lead assessor course, passed the examination, and became registered with the Institute of Quality Assurance (IQA) in the United Kingdom. The original course was developed by a consultant along with one future instructor. Course content used traditional auditing methodology, but included many team exercises including an actual factory audit. The paper describes the methods and contents of this training course

  19. [ISO 9001 conformity in research, teaching and rehabilitation].

    Science.gov (United States)

    Howorka, K; Kletschka, G; Pumprla, J; Thoma, H

    1998-01-01

    Quality assurance, in particular in the areas of development and production of medical devices, is one of the tasks of biomedical engineering. The interdisciplinary working group "Functional Rehabilitation and Group Education, Vienna" is committed to the development and implementation of group education models on three levels: (1) direct education/instruction of patients with chronic diseases, (2) university research and teaching, and (3) development of technical aids for rehabilitation and the means for disseminating group education models in rehabilitation and therapy. Major aims were, by generating conformity with ISO 9001 standards, to achieve greater transparency and process optimization with very small resources in university (teaching, research, technical aids) and extra-university (rehabilitation) areas. A secondary aim was the establishment of interdisciplinary (clinical and biomedical) cooperation at university level. In all main areas (research, teaching and group education/instruction), ISO 9001-conformity was achieved by our activities on three methodological levels: (1) description and analysis of processes, (2) use of ISO 9001 standards for evaluating internal processes, and (3) optimization measures. The following article contains relevant elements of the quality manual and quality assurance system, and offers a typical example of innovative cooperation between medicine and medical engineering.

  20. Global Impact Estimation of ISO 50001 Energy Management System for Industrial and Service Sectors

    Energy Technology Data Exchange (ETDEWEB)

    Aghajanzadeh, Arian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Therkelsen, Peter L. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rao, Prakash [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McKane, Aimee T. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-08-01

    A methodology has been developed to determine the impacts of ISO 50001 Energy Management System (EnMS) at a region or country level. The impacts of ISO 50001 EnMS include energy, CO2 emissions, and cost savings. This internationally recognized and transparent methodology has been embodied in a user friendly Microsoft Excel® based tool called ISO 50001 Impact Estimator Tool (IET 50001). However, the tool inputs are critical in order to get accurate and defensible results. This report is intended to document the data sources used and assumptions made to calculate the global impact of ISO 50001 EnMS.

  1. The neuroprotective effects of α-iso-cubebene on dopaminergic cell death: involvement of CREB/Nrf2 signaling.

    Science.gov (United States)

    Park, Sun Young; Son, Beung Gu; Park, Young Hoon; Kim, Cheol-Min; Park, Geuntae; Choi, Young-Whan

    2014-09-01

    As a part of ongoing studies to elucidate pharmacologically active components of Schisandra chinensis, we isolated and studied α-iso-cubebene. The neuroprotective mechanisms of α-iso-cubebene in human neuroblastoma SH-SY5Y cells were investigated. α-Iso-cubebene significantly inhibited cytotoxicity and apoptosis due to 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in dopaminergic SH-SY5Y cells. Pretreatment of cells with α-iso-cubebene reduced intracellular accumulation of ROS and calcium in response to 6-OHDA. The neuroprotective effects of α-iso-cubebene were found to result from protecting the mitochondrial membrane potential. Notably, α-iso-cubebene inhibited the release of apoptosis-inducing factor from the mitochondria into the cytosol and nucleus after 6-OHDA treatment. α-Iso-cubebene also induced the activation of PKA/PKB/CREB/Nrf2 and suppressed 6-OHDA-induced neurotoxicity. α-Iso-cubebene was found to induce phosphorylation of PKA and PKB and activate Nrf2 and CREB signaling pathways in a dose-dependent manner. Additionally, α-iso-cubebene stimulated the expression of the antioxidant response genes NQO1 and HO-1. Finally, α-iso-cubebene-mediated neuroprotective effects were found to be reversible after transfection with CREB and Nrf2 small interfering RNAs.

  2. Interpretation of MS ISO/ IEC 17020

    International Nuclear Information System (INIS)

    Mohamad Pauzi Ismail

    2012-01-01

    MS ISO/ IEC 17020 is an international standard which adopted by Malaysian Standard states the requirement criteria for inspection bodies. The author involved in the NDT technical assessment to several NDT companies in Malaysia. The experience in performing NDT assessment activity is explained and discussed. (author)

  3. A Cross-Country Empirical Study Towards the Impact of Following ISO Management System Standards on Euro-Area Economic Confidence

    Directory of Open Access Journals (Sweden)

    Ştefan Daniel Armeanu

    2017-02-01

    Full Text Available This study aims to examine the impact of following ISO management system standards on economic sentiment indicator (ESI as proxy of economic agents’ general view concerning economic activity, for 21 European Union member states over 2005-2014. The empirical research comprises ISO standards with reference to management systems towards quality (ISO 9001, ISO 13485, ISO 16949, food safety (ISO 22000, environment (ISO 14001, and information security (ISO 27001. Panel data fixed effects regression models provide support for a positive impact of the quality management systems related to automotive industry, as well as information security management systems, on the ESI. Further, dynamic panel data approach by way of two-step system generalized method of moments emphasizes a positive influence of quality management systems standard for the medical device industry on Euro-area economic confidence, but a negative effect of food safety management systems. Also, ISO 9001, ISO 22000, and ISO 14001 Granger cause ESI.

  4. Plasma 8-iso-Prostaglandin F2α concentrations and outcomes after acute intracerebral hemorrhage.

    Science.gov (United States)

    Du, Quan; Yu, Wen-Hua; Dong, Xiao-Qiao; Yang, Ding-Bo; Shen, Yong-Feng; Wang, Hao; Jiang, Li; Du, Yuan-Feng; Zhang, Zu-Yong; Zhu, Qiang; Che, Zhi-Hao; Liu, Qun-Jie

    2014-11-01

    Higher plasma 8-iso-Prostaglandin F2α concentrations have been associated with poor outcome of severe traumatic brain injury. We further investigated the relationships between plasma 8-iso-Prostaglandin F2α concentrations and clinical outcomes in patients with acute intracerebral hemorrhage. Plasma 8-iso-Prostaglandin F2α concentrations of 128 consecutive patients and 128 sex- and gender-matched healthy subjects were measured by enzyme-linked immunosorbent assay. We assessed their relationships with disease severity and clinical outcomes including 1-week mortality, 6-month mortality and unfavorable outcome (modified Rankin Scale score>2). Plasma 8-iso-Prostaglandin F2α concentrations were substantially higher in patients than in healthy controls. Plasma 8-iso-Prostaglandin F2α concentrations were positively associated with National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volume using a multivariate linear regression. It emerged as an independent predictor for clinical outcomes of patients using a forward stepwise logistic regression. ROC curves identified the predictive values of plasma 8-iso-Prostaglandin F2α concentrations, and found its predictive value was similar to NIHSS scores and hematoma volumes. However, it just numerically added the predictive values of NIHSS score and hematoma volume. Increased plasma 8-iso-Prostaglandin F2α concentrations are associated with disease severity and clinical outcome after acute intracerebral hemorrhage. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. A study of ISO Solenoid Valve with static and dynamic characteristics

    International Nuclear Information System (INIS)

    Jeon, Y. S.; Ju, M. J.; Oh, Y. C.; Kim, D. S.

    2009-01-01

    The technology of ISO Solenoid Valves is now considered as a core technology in the fields of the production line of semi-conductor chips and the ISO fluid chips for medical applications. And ISO Solenoid Valves, which operate by compressed air, are characterized by high speed response, great repeatability and that the pressure on the cross sectional area of poppet is kept constant regardless of the fluctuation of the pressure exerted on the ports. The primary objective of this study is to compare the optimally designed Solenoid Valve with the actually produced one and to design a power saving circuit which can highly improve the efficiency by providing optimal current according to mechanical load.

  6. ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.

    Science.gov (United States)

    Ioannou, Kyriaki; Cheng, Kai Fan; Crichlow, Gregg V; Birmpilis, Anastasios I; Lolis, Elias J; Tsitsilonis, Ourania E; Al-Abed, Yousef

    2014-10-01

    Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory cytokine, which possesses a contributing role in cancer progression and metastasis and, thus, is now considered a promising anticancer drug target. Many MIF-inactivating strategies have proven successful in delaying cancer growth. Here, we report on the synthesis of ISO-66, a novel, highly stable, small-molecule MIF inhibitor, an analog of ISO-1 with improved characteristics. The MIF:ISO-66 co-crystal structure demonstrated that ISO-66 ligates the tautomerase active site of MIF, which has previously been shown to play an important role in its biological functions. In vitro, ISO-66 enhanced specific and non-specific anticancer immune responses, whereas prolonged administration of ISO-66 in mice with established syngeneic melanoma or colon cancer was non-toxic and resulted in a significant decrease in tumor burden. Subsequent ex vivo analysis of mouse splenocytes revealed that the observed decrease in tumor growth rates was likely mediated by the selective in vivo expansion of antitumor-reactive effector cells induced by ISO-66. Compared to other MIF-inactivating strategies employed in vivo, the anticancer activity of ISO-66 is demonstrated to be of equal or better efficacy. Our findings suggest that targeting MIF, via highly specific and stable compounds, such as ISO-66, may be effective for cancer treatment and stimulation of anticancer immune responses.

  7. ISO 9000 and 10CFR50, appendix B-one, both, or neither?

    International Nuclear Information System (INIS)

    Nau, D.C.; Hunt, G.L.

    1993-01-01

    The evolution of quality system requirements has led to the development of standards that either have been tailored for use in specific industries (as in the case of 10CFR50, Appendix B) or have been made generic for use in commercial operations (as in the case of the ISO 9000 series of standards). The elements of many quality systems are shared to a large degree, and the requirements of the standards only generally differ in certification, training, and documentation requirements. The proof of conformance to the requirements of 10CFR50, Appendix B, and ISO 9001 is in large part identical. Table I provides an example of the quality elements common between 10CFR50, Appendix B, and ISO 9001. Substantive proof that a supplier's qualification system meets the requirements of 10CFR50, Appendix B, can substantially be used as proof of conformance to ISO 9001

  8. [Effects of the ISO 15189 accreditation on Nagoya University Hospital].

    Science.gov (United States)

    Yoshiko, Kenichi

    2012-07-01

    The Department of Clinical Laboratory, Nagoya University Hospital acquired ISO 15189 accreditation in November, 2009. The operation of our Quality Management System (QMS) was first surveyed in October, 2010. In this paper, we reported the activity for the preparation and operation of our QMS and the effects of ISO 15189 accreditation. We investigated the changes in the number and content on nonconformities, incident reports and complaints before and after accreditation as indicators to evaluate the effect of ISO 15189 accreditation. Post accreditation, the number of nonconformities and incident reports decreased, seeming to show an improvement of quality of the laboratory activity; however, the number of complaints increased. We identified the increase of complaints at the phlebotomy station. There had been some problems with blood sampling in the past, but it seemed that staff had a high level of concern regarding these problems at the phlebotomy station and took appropriate measures to resolve the complaints. We confirmed that the ISO 15189 accreditation was instrumental in the improvements of the safety and efficiency on laboratory works. However there was a problem that increase of overtime works to operate the QMS. We deal with development of a laboratory management system using IT recourses to solve the problem.

  9. The role of the IEC and ISO in radiological protection

    International Nuclear Information System (INIS)

    White, D.F.

    1976-01-01

    The history, objectives, structures and functions of the International Electrotechnical Commission (IEC) and the International Organisation for Standardisation (ISO) are summarized. The IEC is affiliated to the ISO as its electrical division, but has technical and financial autonomy. Member countries of the EEC may be committed to the adoption of their formal agreements ('Standards') if these become incorporated as Directives. The national standardisation organisations, such as BSI in the U.K., form national committees and are responsible for submitting to the IEC the co-ordinated national viewpoints on particular subjects. The overall links between the technical committees and sub-committees of the ISO, IEC and BSI in the field of radiological protection are tabulated, and the relevant International Standards produced, or in the course of preparation, by the appropriate committees of the ISO and the IEC are listed. The bulk of the effort of the BSI committees is now aimed at the production of acceptable international standards. Compatible national standards then follow. This policy is in contrast to the earlier initial emphasis on national standards, and the improved international collaboration has had two welcome effects. The selection of proposals for standards is more critical, and compatibility with the relevant ICRP and ICRU publications is almost a prerequisite for any international standard. (U.K.)

  10. DIFFERENCES IN MANAGER ASSESSMENTS OF ISO 14000 STANDARD IMPLEMENTATION IN TURKEY

    Directory of Open Access Journals (Sweden)

    Sıtkı Gözlü

    2005-12-01

    Full Text Available This study reports the results of a survey about the improvements achieved as result of ISO 14000 Environmental Management System (EMS standard implementation and the differences of improvements with respect to firm characteristics. A survey has been conducted in order to explain the improvements related to environmental management process and overall firm performance. The survey involved sixty-six enterprises implementing ISO 14000 EMS standard in Turkey. In order to assess improvements obtained from ISO 14000 EMS implementation, statements related to environmental management process and overall firm performance indicators have been prepared. The statements in this study are relevant to previous research. A factor analysis was employed to determine the factors of the variables explaining improvements. Nine factors have been identified related to achieved improvements, such as establishment of pro-active environmental management system, effectiveness in resource utilization, effectiveness of process control, relationships with industry and government, meeting expectations of stakeholders, demonstration of social responsibility, profitability, productivity, and competitiveness. Then, a T- test was conducted to determine the differences of managers’ assessments with respect to certain firm characteristics. The findings have shown that there are differences in the assessments of improvements achieved as a result of ISO 14000 EMS standard implementation with respect to sales volume, foreign-capital possession, and ISO 14000 EMS standard implementation. On the other hand, industrial sector, age of establishment, and export orientation are not statistically significant for the differences in the assessments of improvements.

  11. Laboratory accreditation complying with ISO 25 Guide (IRAM 301): Industrial radiography method

    International Nuclear Information System (INIS)

    Schneebeli, Jorge E.; Zampini, Juan J.; Naucevich, Alfredo

    2000-01-01

    The ISO 25 Guide (IRAM 301) replaced by ISO 17025 is the standard applied for the implementation of a quality system in a test or calibration laboratory. This document is not known as ISO 9000, but it is the proper standard for this kind of laboratory. This document establishes requirements no just for the quality system in general, but on technical competence, that means the laboratory technical aptitude to carry out the tests. The aim of this paper is to comment the criteria used in the Radiographic Laboratory of CEMEC, that have been assessed by the United King dome Accreditation Service (UKAS). (author)

  12. Occupational exposures at nuclear power plants. Fourteenth annual report of the ISOE programme, 2004

    International Nuclear Information System (INIS)

    2006-01-01

    The ISOE Programme was created by the OECD Nuclear Energy Agency in 1992 to promote and co-ordinate international co-operative undertakings in the area of worker protection at nuclear power plants. The programme provides experts in occupational radiation protection with a forum for communication and exchange of experience. The ISOE databases enable the analysis of occupational exposure data from 478 operating and shutdown commercial nuclear power plants participating in the programme (representing some 90% of the world's total operating commercial reactors). The Fourteenth Annual Report of the ISOE Programme summarises achievements made during 2004 and compares annual occupational exposure data. Principal developments in ISOE participating countries are also described. (author)

  13. Occupational exposures at nuclear power plants. Eleventh annual report of the Isoe programme, 2001

    International Nuclear Information System (INIS)

    2002-01-01

    The ISOE Programme was created by the OECD Nuclear Energy Agency in 1992 to promote and co-ordinate international co-operative undertakings in the area of worker protection at nuclear power plants. The programme provides experts in occupational radiation protection with a forum for communication and exchange of experience. The ISOE databases enable the analysis of occupational exposure data from the 452 commercial nuclear power plants participating in the programme (representing some 90 per cent of the world's total operating commercial reactors). The Eleventh Annual Report of the ISOE Programme summarises achievements made during 2001 and compares annual occupational exposure data. Principal developments in ISOE participating countries are also described. (author)

  14. Estimating ecosystem iso/anisohydry using microwave satellite data and its applications in ecohydrology

    Science.gov (United States)

    Li, Y.; Guan, K.; Gentine, P.; Konings, A. G.; Bhattacharya, A.; Meinzer, F. C.; Kimball, J. S.; Xu, X.; Anderegg, W.; McDowell, N. G.; Martínez-Vilalta, J.; Long, D. G.; Good, S. P.

    2017-12-01

    The concept of iso/anisohydry describes the degree to which plants regulate their water status, operating from isohydric with strict stomatal closure to anisohydric with greater stomatal conductance under drying conditions. Though some species-level measures of iso/anisohydry exist at limited locations, ecosystem scale information is still largely unavailable. In this study, we use diurnal observations from active (Ku-Band backscatter from QuikSCAT) and passive (X-band Vegetation Optical Depth [VOD] from AMSR-E) microwave satellite data to estimate global ecosystem iso/anisohydry. The two independent estimates from radar backscatter and VOD show good agreement at low and mid-latitudes but diverge at high latitudes. Grasslands, croplands, wetlands, and open shrublands are more anisohydric, whereas evergreen broadleaf and deciduous broadleaf forests are more isohydric. The direct validation with upscaled in-situ species iso/anisohydry estimates indicates that the VOD estimates have much better agreement than the backscatter in terms of their iso/anisohydry metrics. The indirect validation suggests that both estimates are consistent with prior knowledge that vegetation water status of anisohydric ecosystems more closely tracks environmental fluctuations of water availability and demand than their isohydric counterparts. The ecosystem level iso/anisohydry can be applied to reveal new insights into spatio-temporal ecosystem response to droughts. We conducted a case study to demonstrate the potential application of iso/anisohydry. We find that during the 2011 drought in US, over the drought affected region in the southern US, isohydric ecosystems experienced larger decline in productivity (NDVI and GPP) than anisohydric ones. However, during the 2012 drought in central US, both isohydric and anisohydric ecosystems exhibited similar decline in productivity.

  15. Listen to ISO 9001:2015 for organizational competitiveness: Correlation between change management and improvement

    OpenAIRE

    Fonseca Luis Miguel; Domingues José Pedro

    2017-01-01

    In their quest to achieve superior performance and business results, organizations have extensively adopted models such as ISO 9001 Quality Managements Standards. Research supports that Quality Management System brings significant benefits for organizations competitiveness and success and more than 1 million organizations of all activity sectors worldwide have implemented ISO 9001. In a world of increasingly complexity and interconnection, the revised ISO 9001:2015 International Standard aims...

  16. Corporate environmental policy statements in mainland China: to what extent do they conform to ISO 14000 documentation?

    Science.gov (United States)

    Chung, Shan Shan; Fryxell, Gerald E; Lo, Carlos W H

    2005-04-01

    For decades, industry has been the main source of pollution in China. Determined to make changes, the mainland Chinese authorities have decided to promote mechanisms that incorporate environmental concerns into the internal management of enterprises. This is manifested in the rapid adoption of the ISO14000 standards, including a significant increase in ISO14001 registrations in China. Thus, this study examined the environmental policy statements of 106 certified facilities in mainland China against a strict interpretation of the mandatory requirements of the ISO 14001:1996 standard and the nonmandatory ISO14004 requirements in order to shed some light on the implementation of environmental management systems in an emerging economic giant. It was decided to analyze the environmental policy statement because such a statement is a core element in the ISO system of environmental management of each facility and there are relatively clear and specific requirements on what an environmental policy statement shall include. An analysis of the contents of the environmental policy statements shows that conformance to the relevant requirements of both the mandatory ISO14001 standard and the nonmandatory ISO14004 standard is far from impressive and that the facilities in our sample seldom went beyond the minimum requirements. By using ISO14001 and ISO14004 conformance scores as the dependent variables, we found that conformity to ISO14001 and overall conformance to ISO14000 series can be explained to some extent by the degree of top management commitment, the experience with informal environmental management systems, and the form of ownership of the facilities.

  17. Listen to ISO 9001:2015 for organizational competitiveness: Correlation between change management and improvement

    Directory of Open Access Journals (Sweden)

    Fonseca Luis Miguel

    2017-07-01

    Full Text Available In their quest to achieve superior performance and business results, organizations have extensively adopted models such as ISO 9001 Quality Managements Standards. Research supports that Quality Management System brings significant benefits for organizations competitiveness and success and more than 1 million organizations of all activity sectors worldwide have implemented ISO 9001. In a world of increasingly complexity and interconnection, the revised ISO 9001:2015 International Standard aims to ensure that Quality Management Systems are flexible while remaining reliable. The concept of Change Management was introduced in the standard and Improvement can be achieved both in a continual/incremental mode (already present in the ISO 9001:2008 edition and in a breakthrough change/disruptive mode (new in ISO 9001:2015. ISO 9001:2015 is now closer to Business Excellence Models, such as the EFQM, that highlight the need for agility and flexibility for enduring success. To access if organizations that have already implemented ISO 9001:2015 are indeed managing change and achieving improvement, and if there is a relationship between these two variables, a survey was held with IRCA ISO 9001 Registered Auditors on a worldwide basis. Sample normality was confirmed trough Kolmogorov-Smirnov Test and the hypothesis was tested by using Pearson Correlation coefficient. The findings show that the auditee organizations have positively implemented ISO 9001:2015 requirements on change management and improvement. There is also a strong positive correlation between change management and improvement, suggesting that the organizations that properly manage change by planning, designing, implementing, and controlling change in an effective and efficient way, demonstrate a higher level of performance and results improvement. These conclusions have significant implications for the Quality/Organizational Excellence Management Body of Knowledge, requiring a new way of

  18. Vergelijking van een tijd besparende analysemethode voor hydroxyproline met ISO 3496-1978

    NARCIS (Netherlands)

    Cazemier, G.; Tuinstra, L.G.M.Th.; Werdmuller, G.A.

    1988-01-01

    De bepaling van hydroxyproline volgens de referentiemethode ISO 3496 is zeer tijdrovend. In een door het Nordisk Metodikkomitti för Livsmedel voorgestelde methode is een aantal wijzigingen ten opzichte van ISO 3496 aangebracht die de analysetijd per monster sterk verkorten. Om na te gaan of deze

  19. Analysis of the Air Force ISO 14001 Pilot Study Conducted by DoD

    National Research Council Canada - National Science Library

    Harris, Rodney

    2000-01-01

    The Department of Defense (DoD) conducted an ISO 14001 pilot study with the primary goal of determining how ISO 14001 could help DoD organizations reduce risks, improve compliance with environmental regulations, enhance stewardship...

  20. Sensorless adaptive optics for isoSTED nanoscopy

    Science.gov (United States)

    Antonello, Jacopo; Hao, Xiang; Allgeyer, Edward S.; Bewersdorf, Joerg; Rittscher, Jens; Booth, Martin J.

    2018-02-01

    The presence of aberrations is a major concern when using fluorescence microscopy to image deep inside tissue. Aberrations due to refractive index mismatch and heterogeneity of the specimen under investigation cause severe reduction in the amount of fluorescence emission that is collected by the microscope. Furthermore, aberrations adversely affect the resolution, leading to loss of fine detail in the acquired images. These phenomena are particularly troublesome for super-resolution microscopy techniques such as isotropic stimulated-emission-depletion microscopy (isoSTED), which relies on accurate control of the shape and co-alignment of multiple excitation and depletion foci to operate as expected and to achieve the super-resolution effect. Aberrations can be suppressed by implementing sensorless adaptive optics techniques, whereby aberration correction is achieved by maximising a certain image quality metric. In confocal microscopy for example, one can employ the total image brightness as an image quality metric. Aberration correction is subsequently achieved by iteratively changing the settings of a wavefront corrector device until the metric is maximised. This simplistic approach has limited applicability to isoSTED microscopy where, due to the complex interplay between the excitation and depletion foci, maximising the total image brightness can lead to introducing aberrations in the depletion foci. In this work we first consider the effects that different aberration modes have on isoSTED microscopes. We then propose an iterative, wavelet-based aberration correction algorithm and evaluate its benefits.

  1. ISO 9001 benefits and pitfalls: the path to successful certification.

    Science.gov (United States)

    Krause, M S

    1996-09-01

    The lifeblood of a business is developing and commercializing new products with minimum cost and time and maximum quality. Implementation of a quality management system is often used to achieve these goals, and the ISO 9001 standard for a business quality system is rapidly becoming the model of choice. The existence of an ISO-compliant system is a key to meeting the forthcoming regulatory requirements in the European Union and the US Food and Drug Administrations's proposed good management practices. DuPont has demonstrated leadership in the achievement of ISO registration. I describe the path to these successful registrations along with key lessons from the experience. Elements of success are management commitment, adequate resources, education, communication, total organizational involvement, and auditing of system performance. For the system to flourish and provide benefits to the users, sufficient time must be allocated for the organization to change.

  2. Formation of iso-ursodeoxycholic acid during administration of ursodeoxycholic acid in man

    NARCIS (Netherlands)

    Beuers, U.; Fischer, S.; Spengler, U.; Paumgartner, G.

    1991-01-01

    The appearance of iso-ursodeoxycholic acid (isoUDCA; 3 beta,7 beta-dihydroxy-5 beta-cholan-24-oic acid) in serum of patients with chronic cholestatic liver disease and of healthy subjects during administration of ursodeoxycholic acid (UDCA) is reported. Comparison of the mass spectrum of the newly

  3. Handbook on Life Cycle Assessment. Operational Guide to the ISO Standards

    Energy Technology Data Exchange (ETDEWEB)

    Guinee, J.B. [Centre of Environmental Studies, Leiden University, Leiden (Netherlands)

    2002-04-01

    In 1992 the Centre of Environmental Science (CML) at Leiden University, The Netherlands, published a Guide on Environmental Life Cycle Assessment (LCA) methodology, setting the standard for a long time. Since then LCA methodology has progressed enormously and the International Organization for Standardization (ISO) has published a series of Standards on LCA. These developments have now been incorporated into a new Handbook on LCA authored by CML in cooperation with a number of other important institutes in the area of LCA. The general aim of this Handbook on LCA is to provide a stepwise 'cookbook' with operational guidelines for conducting an LCA study step-by-step, justified by a scientific background document, based on the ISO Standards for LCA. The different ISO elements and requirements are made operational to the 'best available practice' for each step. CML is strongly involved in the development of a standard methodology to determine environmental impacts of products, i.e., LCA. This is done within international fora such as the Society for Environmental Toxicology and Chemistry (SETAC), the International Organization for Standardization (ISO), and the United Nations Environmental Programme (UNEP)

  4. PENGUKURAN KUALITAS PERANGKAT LUNAK SISTEM INFORMASI HOTEL BERBASIS STANDARD ISO 9126

    Directory of Open Access Journals (Sweden)

    Asih Sutanti

    2016-02-01

    Full Text Available Penelitian ini bertujuan bagaimana mengukur perangkat lunak yang dilihat dari sudut pandang produk, mengukur kualitas perangkat  lunak Sistem Informasi Hotel yang memerlukan  alat bantu untuk mempermudah melakukan pengukuran kualitas software tersebut berdasarkan ISO 9126 yang sesuai dengan enam karakteristik dari model kualitas software/perangkat lunak yaitu Functionability, Reliability, usability, efesiency, maintainability dan portability. Faktor kualitas umum yang paling penting diurutkan dan ditambahkan ke sub-faktor dari ISO 9126. Sehingga pihak manajemen dalam pengukurannya lebih akurat dalam memperoleh informasi untuk menentukan keputusan strategis. Melalui pemrosesan data dari masukan pengguna terhadap tingkat preferensi faktor dan sub-faktor kualitas akan diperoleh bobot faktor kualitas dan bobot relatif sub-faktor kualitas. Perkalian kedua nilai tersebut akan menghasilkan bobot absolut yang kemudian dikalikan dengan penilaian kriteria aplikasi hotel dari pengguna. Hasil akhirnya berupa nilai kualitas total dari aplikasi perangkat lunak Sistem Informasi Hotel. Setelah dilakukan pengukuran dengan enam karakteristik Standart ISO 9126, diperoleh nilai  Sistem Informasi Hotel 13.25 yang merupakan hasil pengukuran kualitas sehingga aplikasi ini tidak masuk kategori standar ISO 9126 karena ada Karakteristik Portability yait u unsur Adaptability, dan Installability tidak terpenuhi.

  5. Environmental Management Systems (EMS ISO 14001 Implementation in Construction Industry: A Malaysian Case Study

    Directory of Open Access Journals (Sweden)

    Sumiani Yusoff

    2015-03-01

    Full Text Available This study seeks to explore the crucial part in EMS implementation; i.e. environmental aspects and impacts, Good Environmental Practice to be developed in construction site, as well as the level of awareness or understanding amongst site staffs on ISO 14001 EMS implementation in their organizations. Data were collected via interviews, surveys and site visits. A number of environmental aspects and impacts, and Good Environmental Practices based on ISO 14001:2004 have been identified. The level of understanding of the site staffs on ISO 14001 EMS requirements has been found to be good except for matters concerning Schedule Waste Management. In conclusion, the successful implementation of ISO 14001 EMS mainly depends on staffs‘ understanding.

  6. ISO 14001 ENVIRONMENTAL MANAGEMENT SYSTEMS FOR GOVERNMENT

    Science.gov (United States)

    This presentation provides an overview of the document, ISO 14001 - A Tool for Supporting Government Environmental Programs and Policies, recently published by USEPA/s Office of Research and Development. It is an informational document, explaining the backjground and development ...

  7. Performance improvement with ISO 9001:2000: a case of PKOC-II project

    Energy Technology Data Exchange (ETDEWEB)

    Behera, U.K.; Prasad, K.S.N. [Singareni Collieries Co. Ltd. (India)

    2006-07-01

    The present study is limited to the study of main step towards ISO 9001:2000 (QMS) development, implementation and improvements of PKOC-II project and the same are discussed. In line with increasing global concern for quality, environmental protection and occupational health and safety, Singareni Collieries Co. Ltd (SCCL) has taken the strategic decision to implement ISO 9001:2000 (QMS), ISO 14001:2004 EMS (environmental management system) and occupational health and safety assessment series 18001:1999 (OHSAS) at the PK OC-II project. This is the first project to implement all three management systems QMS, OHSAS, and EMS, in the Indian coal industry. 25 refs., 12 figs., 2 tabs.

  8. Molecular mechanisms behind the antimicrobial activity of hop iso-α-acids in Lactobacillus brevis.

    Science.gov (United States)

    Schurr, Benjamin C; Hahne, Hannes; Kuster, Bernhard; Behr, Jürgen; Vogel, Rudi F

    2015-04-01

    The main bittering component in beer, hop iso-α-acids, have been characterised as weak acids, which act as ionophores impairing microbial cells' function under acidic conditions as present in beer. Besides medium pH, divalent cations play a central role regarding the efficacy of the antimicrobial effect. The iso-α-acids' non-bitter derivatives humulinic acids can be found in isomerised hop extracts and can be generated during hop storage. Therefore, they have been under investigation concerning their influence on beer sensory properties. This study sketches the molecular mechanism behind iso-α-acids' antimicrobial activity in Lactobacillus (L.) brevis regarding their ionophore activity versus the dependence of the inhibitory potential on manganese binding, and suggests humulinic acids as novel tasteless food preservatives. We designed and synthesised chemically modified iso-α-acids to enhance the basic understanding of the molecular mechanism of antimicrobial iso-α-acids. It could be observed that a manganese-binding dependent transmembrane redox reaction (oxidative stress) plays a crucial role in inhibition. Privation of an acidic hydroxyl group neither erased ionophore activity, nor did it entirely abolish antimicrobial activity. Humulinic acids proved to be highly inhibitory, even outperforming iso-α-acids. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. An ISO 9001 quality management system in a hospital: bureaucracy or just benefits?

    Science.gov (United States)

    van den Heuvel, Jaap; Koning, Lida; Bogers, Ad J J C; Berg, Marc; van Dijen, Monique E M

    2005-01-01

    To describe how The Red Cross Hospital in Beverwijk, The Netherlands implemented an ISO 9000 quality management system throughout the entire organisation, obtained an ISO 9002:1994 and subsequently an ISO 9001:2000 certificate. First, a global implementation plan was written concerning the process obtaining in each department. Once improved, each process was subjected to a procedure, and specific protocols effected. On completion the Quality Manual was put together. Quality management was completed by implementing an internal audit system involving 50 co-workers. A number of advantages are found from using ISO. The focus on patients has been re-established. All processes are identified and subject to continuous improvement. Performance measurements were introduced and give an integrated picture of results. Measurements subsequently lead to improvement of quality of care and to quality system improvements. The documentation system serves the organization's needs without leading to bureaucracy. Positive effects on patient safety could be demonstrated compared with ten other hospitals. Given the need for adequate quality management tools in health care and the need for demonstrating quality, the positive effects reported in this article show how ISO is expected to become more prevalent in health-care organisations.

  10. KSC Center Director Bridges addresses the audience at an ISO 9001 certification ceremony

    Science.gov (United States)

    1998-01-01

    Center Director Roy Bridges speaks to KSC employees at the ISO certification ceremony held at the Training Auditorium. Bridges was presented an ISO 9001 certificate and plaque awarded to KSC by Det Norske Veritas (DNV), Inc., an international ISO certification organization. ISO 9001 comprises the most detailed, comprehensive set of standard requirements for quality programs established by the International Standards Organization. The presentation followed a successful independent audit by DNV of the KSC Management System in May of this year. The third-party auditors examined about 20 elements of KSC's system, including management responsibility, design control, documentation, test and inspection, and corrective action procedures. DNV found that KSC met or exceeded the stringent quality standards in all areas. KSC will use this certification as a tool to improve an already world- class team. All NASA centers are required by NASA Administrator Daniel S. Goldin to be ISO 9001 registered by September 1999. NASA is the first federal agency to seek the quality certification. Next to Bridges is Heidi Hollingsworth, with the Center for Independent Living, who uses American Sign Language for any hearing-impaired employees in the audience.

  11. Complementing network security to the ISO/IEC 27000 standard

    OpenAIRE

    Alila, Patrick

    2007-01-01

    I syfte att öppna upp nya affärsmöjligheter för informationssäkerhetsföretaget Secure State AB, har detta arbete bedrivits för att komplettera företagets nuvarande standard för informationssäkerhetsarbete med ytterligare nätverkssäkerhet. Krav på slutresultatet var att dokumentet eller standarden skulle kunna komplettera ISO 27000, samt vara kostnadseffektivt. Efter en undersökning av den nämnda standarden konstaterades att enbart ISO 27000 i sig inte är ett fullgott verktyg för nätverkssäker...

  12. Implementation of ISO 22000 in Romanian Companies: Motivations, Difficulties and Key Benefits

    Directory of Open Access Journals (Sweden)

    Carmen Păunescu

    2018-02-01

    Full Text Available The development of well-designed food safety management systems that take into consideration the potential risks and threats to an organization and their associated impacts to business operations should be a key goal for each organization operating in the food supply chain. This study provides quantitative empirical evidence about the motivations for implementing a food safety management system based on ISO 22000. By employing factor analysis and multiple linear regression, it analyses the benefits that the ISO 22000 certified companies gained through certification, as well as the main constraints that may prevent the adoption of the standard in the food industry. The survey is based on a sample of Romanian companies distributed at all levels of the food chain, but mainly at the production level. While there exist external pressures that lead companies to adopt a food safety management system based on ISO 22000, the motivations that are most relevant in this decision are generally internal in nature. The results of our study identify three major benefits of ISO 22000 certification: food safety improvement and provision of safer products, reduction of illness and other risks arising from food and improvement of consumers’ confidence. Also, it points out three constraints limiting the dissemination and use of ISO 22000: employees’ qualification, costs associated with food safety management system implementation and legal requirements.

  13. Adsorption and separation of n/iso-pentane on zeolites: A GCMC study.

    Science.gov (United States)

    Fu, Hui; Qin, Hansong; Wang, Yajun; Liu, Yibin; Yang, Chaohe; Shan, Honghong

    2018-03-01

    Separation of branched chain hydrocarbons and straight chain hydrocarbons is very important in the isomerization process. Grand canonical ensemble Monte Carlo simulations were used to investigate the adsorption and separation of iso-pentane and n-pentane in four types of zeolites: MWW, BOG, MFI, and LTA. The computation of the pure components indicates that the adsorption capacity is affected by physical properties of zeolite, like pore size and structures, and isosteric heat. In BOG, MFI and LTA, the amount of adsorption of n-pentane is higher than iso-pentane, while the phenomenon is contrary in MWW. For a given zeolite, a stronger adsorption heat corresponds to a higher loading. In the binary mixture simulations, the separation capacity of n-and iso-pentane increases with the elevated pressure and the increasing iso-pentane composition. The adsorption mechanism and competition process have been examined. Preferential adsorption contributions prevail at low pressure, however, the size effect becomes important with the increasing pressure, and the relatively smaller n-pentane gradually competes successfully in binary adsorption. Among these zeolites, MFI has the best separation performance due to its high shape selectivity. This work helps to better understand the adsorption and separation performance of n- and iso-pentane in different zeolites and explain the relationship between zeolite structures and adsorption performance. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. ISO 13485 a complete guide to quality management in the medical device industry

    CERN Document Server

    Abuhav, Itay

    2011-01-01

    Although complex and lengthy, the process of certification for the ISO 13485 can be easily mastered using the simple method outlined in ISO 13485: A Complete Guide to Quality Management in the Medical Device Industry. Written by an experienced industry professional, this practical book provides a complete guide to the ISO 13485 Standard certification for medical device manufacturing. Filled with examples drawn from the author's experience and spanning different sectors and fields of the medical device industry, the book translates the extra ordinary requirements and objectives of the standard

  15. WHAT IS THE PURPOSE OF ISO 9000 CERTIFICATION? EMPIRICAL EVIDENCE FROM FRENCH MICRO-DATA

    Directory of Open Access Journals (Sweden)

    Sanja Pekovic

    2008-03-01

    Full Text Available The ISO 9000 certification is often associated with quality approach, and activities that are by now widely diffused throughout business. The statistical research shows that quality management practice is one of the most utilized tools because in 1997, more than a third of industrial firms have received the quality certification. Regarded like an investment in a diploma, investment in quality norms can at the same time be a function of improvement of the company's competence and can also make a signal on the market. In our research, we want to understand those two functions of the ISO 9000 certification and to see how they act in the company and on the market. The paper will explore two possible functions of the certification and will analysis the consequences for the firms. The research will use national statistics sources and case research for the empirical investigation to identify the internal characteristics of ISO 9000 adoption. Also, it will use C.O.I database (Organizational Changes and Computerization of 1997 and E.A.E. database (Annual Survey of Industry. In this research, the empirical results show that ISO certification has a part of increase the level of firm's export. Moreover, the firms that have recently adopted the ISO certification invest more in quality than those that have adopted ISO certification more ago. The results show that the firms from same sector of activity "are pushed" to adopt certification. At the end, the results show that, the probability that the firm adopt ISO certification increase with firm's size.

  16. Diseño e implantación de un sistema integrado de calidad y medio ambiente (ISO 9001: 2008 e ISO14001:2004) en una empresa de obra civil

    OpenAIRE

    Campano Calleja, Juan Manuel

    2012-01-01

    El Proyecto Fin de Carrera tiene como objetivos el diseño, desarrollo e implantación de un Sistema de Gestión Integrado de Calidad y de Medio Ambiente según las normas ISO 9001:2008 e ISO 14001:2004 para una empresa ficticia llamada MID EXCAVACIONES S.L.

  17. Iso-acoustic focusing of cells for size-insensitive acousto-mechanical phenotyping

    DEFF Research Database (Denmark)

    Augustsson, Per; Karlsen, Jonas Tobias; Su, Hao-Wei

    2016-01-01

    Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling assessment of effective parameters relating to cells' interior molecular content and structure. Here, we present iso-acoustic focusing, an equilibrium method to analyze the effective acoustic impedance...... of single cells in continuous flow. While flowing through a microchannel, cells migrate sideways, influenced by an acoustic field, into streams of increasing acoustic impedance, until reaching their cell-type specific point of zero acoustic contrast. We establish an experimental procedure and provide...... theoretical justifications and models for iso-acoustic focusing. We describe a method for providing a suitable acoustic contrast gradient in a cell-friendly medium, and use acoustic forces to maintain that gradient in the presence of destabilizing forces. Applying this method we demonstrate iso-acoustic...

  18. Study on the Evolution of the Current ISO Certifications in Romania

    Directory of Open Access Journals (Sweden)

    Teodor Socaciu

    2013-06-01

    Full Text Available To increase the efficiency and effectiveness of processes within an organization, ISO standards can help both large enterprises and small companies (SMEs, both in industrialized and in developing countries offering solutions and bringing considerable advantages in almost all existing fields. ISO certification brings a set of measures in the areas of an organization, be it about quality, environmental safety, food or protection and safety of personnel, this certification brings benefits both in the current processes and more importantly, the future development plans. In this paper, graphs showing the distributions of increasing certification, demonstrate that more and more companies in Romania have realized that, only implementing and certifying ISO standards, they will be successful in domestic and international market in terms of competition, in particular against European companies.

  19. 75 FR 16096 - New England Power Generators Association Inc., Complainant v. ISO New England Inc., Respondent...

    Science.gov (United States)

    2010-03-31

    ...-787-000] New England Power Generators Association Inc., Complainant v. ISO New England Inc., Respondent; ISO New England Inc. and New England Power Pool; Notice of Complaint March 24, 2010. Take notice... Inc. (Complainant) filed a formal complaint against ISO New England Inc. (Respondent) alleging that...

  20. ISO19770-1:2012 SAM process guidance

    CERN Document Server

    Canavan, Rory

    2012-01-01

    The pocket guide offers a concise summary of the principles of software asset management as conveyed by ISO 19770-1: 2012, and provides advice and guidance on how to kick-start your own SAM programme - something the Standard alone doesn't offer.

  1. Infra-slow oscillation (ISO of the pupil size of urethane-anaesthetised rats.

    Directory of Open Access Journals (Sweden)

    Tomasz Blasiak

    Full Text Available Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈ 29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈ 2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.

  2. ITIL and ISO/IEC 20000 a practical handbook

    CERN Document Server

    Hernandez, Alex

    2012-01-01

    The purpose of this publication is to provide your organization with a pragmatic approach to effectively implementing service management, incorporating practices from the ITIL framework and the ISO/IEC 20000 standard.

  3. [Quality management according to DIN EN ISO 9001 at a university eye hospital].

    Science.gov (United States)

    Schönherr, U; Händel, A; Naumann, G O

    2001-02-01

    Quality assurance is an integral part of modern microsurgical ophthalmology. Health care laws also mandate overall quality management. In recent years we have standardized the preexisting features of quality management according DIN EN ISO 9001 and have integrated previously missing features. Establishing quality management according to ISO 9001 is possible even at a university eye hospital and department of ophthalmology. Certification according to ISO 9001 specifications was granted in April 1999. The major difficulty was in translating industrial norms to the context of an eye hospital. It was also difficult to overcome skepticism towards quality-assurance measures that lie beyond ophthalmological quality control. It is useful and feasible to establish a quality management system at German university eye hospitals and departments of ophthalmology. Certification according to ISO 9001 is one possibility to make a quality management system transparent and evaluable both inside and outside the hospital.

  4. Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.

    Science.gov (United States)

    Mastalerz, Lucyna; Januszek, Rafał; Kaszuba, Marek; Wójcik, Krzysztof; Celejewska-Wójcik, Natalia; Gielicz, Anna; Plutecka, Hanna; Oleś, Krzysztof; Stręk, Paweł; Sanak, Marek

    2015-09-01

    Isoprostanes are bioactive compounds formed by non-enzymatic oxidation of polyunsaturated fatty acids, mostly arachidonic, and markers of free radical generation during inflammation. In aspirin exacerbated respiratory disease (AERD), asthmatic symptoms are precipitated by ingestion of non-steroid anti-inflammatory drugs capable for pharmacologic inhibition of cyclooxygenase-1 isoenzyme. We investigated whether aspirin-provoked bronchoconstriction is accompanied by changes of isoprostanes in exhaled breath condensate (EBC). EBC was collected from 28 AERD subjects and 25 aspirin-tolerant asthmatics before and after inhalatory aspirin challenge. Concentrations of 8-iso-PGF2α, 8-iso-PGE2, and prostaglandin E2 were measured using gas chromatography/mass spectrometry. Leukotriene E4 was measured by immunoassay in urine samples collected before and after the challenge. Before the challenge, exhaled 8-iso-PGF2α, 8-iso-PGE2, and PGE2 levels did not differ between the study groups. 8-iso-PGE2 level increased in AERD group only (p=0.014) as a result of the aspirin challenge. Urinary LTE4 was elevated in AERD, both in baseline and post-challenge samples. Post-challenge airways 8-iso-PGE2 correlated positively with urinary LTE4 level (p=0.046), whereas it correlated negatively with the provocative dose of aspirin (p=0.027). A significant increase of exhaled 8-iso-PGE2 after inhalatory challenge with aspirin was selective and not present for the other isoprostane measured. This is a novel finding in AERD, suggesting that inhibition of cyclooxygenase may elicit 8-iso-PGE2 production in a specific mechanism, contributing to bronchoconstriction and systemic overproduction of cysteinyl leukotrienes. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Lean environmental management integration system for sustainability of ISO 14001:2004 standard implementation

    Directory of Open Access Journals (Sweden)

    Perumal Puvanasvaran

    2014-10-01

    Full Text Available Purpose: The purpose of this study is to present a model for integrating Lean Principles with ISO 14001 Environmental Management System.Design/methodology/approach: To achieve the objective of the study, the methodology used in this study is based on preliminary literature review of ISO 14001 standards and Lean Principles as well as certain case reports from various proponents and authors of ISO 14001 and Lean as noted in various articles and journals and some books.Findings and Originality/value: The findings of this study are a new model called Lean Environmental Management Integration System (LEMIS has been developed and leads to the creation of these measurement standards for evaluating the organization, making its environmental efforts more realistic, focused and attainable.Research limitations/implications: Future research should be conducted case studies in this direction are required to be conducted for examining the feasibility of amalgamation and implementing ISO 14001:2004 standards with the philosophy of Lean Principles to enable the achievement of world class standards.Practical implications: This model helps to eliminate any wasteful processes in the organization’s implementation of the ISO 14001 standard thus leading to higher environmental performance.  Integrating the standard with Lean principles through LEMIS model helps to specify these performance measures making the standard achieve sustainability and continual improvement.Originality/value: This study presents a unique approach of integrating the two main models, namely Lean Principles and ISO 14001 Environmental Management System, as a single framework benefiting contemporary organizations.

  6. Diseño e implantación de una oficina técnica según normativa ISO 9001:2000 e ISO 14001:2004, en una empresa del sector aeronautico

    OpenAIRE

    Hucha Sierra, Antonio

    2006-01-01

    El proyecto describirá dos procesos fundamentalmente, el diseño de la empresa de SITA enfocada hacia los Estudios de Ingeniería, y la implantación y certificación de un Sistema de Gestión de Calidad y Medioambiente, según las normativas ISO 9001:2000 e ISO 14001:2004.

  7. Implementation Of ISO 9000 Quality Management System Within The Manufacturing And Service Industry Of Ivory Coast

    Directory of Open Access Journals (Sweden)

    Borget Alfred Anoye

    2015-08-01

    Full Text Available Abstract The objective of this paper was to present the factors that impede the implementation of ISO 9000 QMS within the manufacturing and service Industry of Ivory Coast. It wasnt the intention of the author to provide detailed strategies for the readers to implement ISO 9000. It was an effort to present the relationship if any between the lack of ISO 9000 adoption and the perception of Ivoirians business organization leaders. For that purpose five research questions were associated with this study. The population for this study was all non-ISO certified business organizations in both public and private sector and was physically located in Ivory Coast. The population sample for this study was the 5044 members of the Chambre de Commerce et dIndustrie de Cote dIvoire CCI from which the author utilized the sample size of 60 business organizations randomly selected. This study utilized a survey questionnaire of face to face interview as data collection method. The survey questionnaire contained thirty three 33 questions organized in six parts and was proposed to 60 business organizations leaders. The result showed that business organization leaders in Ivory Coast were aware of the ISO 900 QMS but do not have enough knowledge on the ISO 9000 QMS implementation and certification. This could be due to the poor job done by CODIMORM the local national bureau of standards as a source of information. However it was found that business organization leaders in Ivory Coast intended to pursue and obtain ISO 9000 QMS certification. With respect to perceived benefits they indicated customer satisfaction improvement as the most important benefit that ISO 9000 QMS certification could bring to their general management activities. With respect to perceived improvements they selected quality of productsservices as the most important improvement that ISO 9000 QMS implementation and certification could help to achieve. Overall business organization leaders in Ivory

  8. On the new ISO guide on risk management terminology

    International Nuclear Information System (INIS)

    Aven, Terje

    2011-01-01

    A new ISO guide on risk management terminology has recently been issued. The guide provides basic vocabulary for developing a common understanding of risk assessment and risk management concepts and terms among organisations and functions, and across different application areas. It provides the foundation of, for example, the ISO 31000 standard on risk management. The guide strongly influences the risk assessment and risk management field, and its quality is thus of utmost importance. In this paper a critical review of the guide is conducted. We argue that the guide fails in several ways in producing consistent and meaningful definitions of many of the key concepts covered. A main focus is placed on the risk concept, which is defined as the effect of uncertainty on objectives, but also many other definitions are looked into, including probability, vulnerability, hazard, risk identification and risk description. Examples are used to illustrate the problems and show how they can be rectified. Although the focus is on the ISO guide, the discussion is to a large extent general. The overall aim of the paper is to contribute to the further development of the area of risk assessment and risk management by strengthening its conceptual basis.

  9. Relationship between platelet and urinary 8-Iso-PGF2α levels in subjects with different degrees of NOX2 regulation.

    Science.gov (United States)

    Carnevale, Roberto; Iuliano, Luigi; Nocella, Cristina; Bartimoccia, Simona; Trapè, Stefano; Russo, Roberta; Gentile, Maria Cristina; Cangemi, Roberto; Loffredo, Lorenzo; Pignatelli, Pasquale; Violi, Francesco

    2013-06-14

    Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NOX2. It is unclear if platelets 8-iso-PGF2α contribute to urinary 8-iso-PGF2α. In a cross-sectional study, platelet, urinary, and serum 8-iso-PGF2α were determined in subjects with downregulation (X-linked chronic granulomatous disease [X-CGD], n=25) and upregulation (type II diabetic patients [T2D], n=121) of NOX2 and 153 controls matched for sex and age. In diabetic patients (n=18), the above variables were repeated before and after 7 days treatment with 100 mg/day aspirin or 100 mg/day aspirin plus 40 mg/day atorvastatin. In vitro study was performed to see the contribution of blood cells to serum 8-iso-PGF2α. Compared with controls, X-CGD patients had lower platelet, serum, and urinary 8-iso-PGF2α values; conversely, diabetic patients had higher values of 8-iso-PGF2α compared with controls. Urinary 8-iso-PGF2α significantly correlated with both platelet and serum 8-iso-PGF2α in the 2 cohorts. A parallel increase of platelet, serum, and urinary 8-iso-PGF2α by aspirin and a parallel decrease by aspirin plus atorvastatin were detected in the interventional study. In vitro study demonstrated that platelets contribute to 37% of serum 8-iso-PGF2α and that only 13% of it is of extravascular origin. The study suggests that NOX2 contributes to the formation of 8-iso-PGF2α in both platelets and urine. The direct correlation between platelet and urinary 8-iso-PGF2α suggests that, at least partly, urinary 8-iso-PGF2α reflects platelet 8-iso-PGF2α production. Analysis of serum 8-iso-PGF2α may represent a novel tool to investigate the production of 8-iso-PGF2α by blood cells including platelets. URL: ClinicalTrials.gov. Unique Identifier: NCT01250340.

  10. ISO/IEC 38500 the IT governance standard

    CERN Document Server

    Calder, Alan

    2008-01-01

    The emergence of ISO/IEC 38500 - the international standard for the corporate governance of information and communication technology - puts boards around the world in a position from which they can take effective action to apply core governance principles to their information and communication technology.

  11. X(3872) and Its Iso-Triplet Partners

    OpenAIRE

    Kunihiko, TERASAKI; Yukawa Institute for Theoretical Physics, Kyoto University:Institute for Theoretical Physics, Kanazawa University

    2012-01-01

    Decays of X(3872) and its partners as hidden-charm axial-vector tetra-quark mesons are studied. As the result, it is seen that the iso-triplet partners of X(3872) can be broad, and therefore, higher statistics will be needed to find them.

  12. New ISO standards for hearing protectors (A)

    DEFF Research Database (Denmark)

    Poulsen, Torben

    2000-01-01

    Working Group 17 under ISO/TC43/SC1 deals with measurement of hearing protector attenuation. WG17 is presently involved in revision of the present 4869-1 standard (especially sound field requirements and reproducibility estimations) and formulation of a new standard where inexperienced hearing...

  13. Conformance on Quality Management System of One State College in the Philippines as Basis for ISO Certification

    Directory of Open Access Journals (Sweden)

    Romulo T. Sisno

    2017-11-01

    Full Text Available This study sought to determine the quality management system of the Northern Negros State College of Science and Technology (NONESCOST as basis for International Organization for Standardization (ISO Certification. The descriptive method of research was used in this study. It utilized the ISO 9001:2008 Quality Management System Requirements Checklist and the Questionnaires on the Attitudes towards ISO 9001. The study utilized a descriptive research design.. Findings revealed that the attitude of administrators, teaching personnel and administrative staff’ towards ISO 9001 in terms of benefits, challenges, recommendations and standards did not differ significantly. Findings further revealed that the employees have mostly positive perceptions of ISO 9001, resulting in positive attitudes in the workplace. Findings also revealed that the extent of conformance to the ISO 9001:2008 (QMS Requirements in the areas of Quality Management System, Management Responsibility, Resource Management, Product Realization and Measurement, Analysis and Improvement was perceived by the respondents to be minor non-conformance. It implies that fulfillment to the ISO 9001:2008 Requirements was only satisfactory

  14. Why did ISO 9001:2008 system fail to deliver?

    Science.gov (United States)

    Langford, Melvyn

    2014-02-01

    This article is based on an actual investigation undertaken, and summarises the subsequent report's findings and observations. It has been anonymised for obvious reasons. In May 2013 an analysis was undertaken by a multidisciplinary team that compared an NHS Trust estates department's managerial systems against the NHS national recommendations. The conclusions stated that: 'There was a systemic failure across a large number of topics generating intolerable/substantial risks to the organisation, its staff, and patients; this despite the department's managerial systems being accredited to the International Standard ISO 9001:2008'. The natural question raised when presented with this demonstrable and auditable evidence was: 'Why did the ISO 9001:2008 system fail?'

  15. Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress.

    Science.gov (United States)

    Yang, Jun; Wang, Zhao; Chen, Dong-Lin

    2017-09-01

    Shikonin, isolated from the roots of herbal plant Lithospermum erythrorhizon, is a naphthoquinone. It has been reported to exert beneficial anti-inflammatory effects and anti-oxidant properties in various diseases. Isoproterenol (ISO) has been widely used to establish cardiac injury in vivo and in vitro. However, shikonin function in ISO-induced cardiac injury remains uncertain. In our study, we attempted to investigate the efficiency and possible molecular mechanism of shikonin in cardiac injury treatment induced by ISO. In vivo, C57BL6 mice were subcutaneously injected with 5mg/kg ISO to induce heart failure. And mice were given a gavage of shikonin (2 or 4mg/kg/d, for four weeks). Cardiac function, fibrosis indices, inflammation response, apoptosis and endoplasmic reticulum (ER) stress were calculated. Pathological alterations, fibrosis-, inflammation-, apoptosis- and ER stress-related molecules were examined. In ISO-induced cardiac injury, shikonin significantly ameliorated heart function, decreased myocardial fibrosis, suppressed inflammation, attenuated apoptosis and ER stress through impeding collagen accumulation, Toll like receptor 4/nuclear transcription factor κB (TLR4/NF-κB), Caspase-3 and glucose-regulated protein 78 (GRP78) signaling pathways activity, relieving heart failure in vivo. Also, in vitro, shikonin attenuated ISO-induced cardiac muscle cells by reducing fibrosis, inflammation, apoptosis and ER stress. Our findings indicated that shikonin treatment attenuated ISO-induced heart injury, providing an effective therapeutic strategy for heart failure treatment for future. Copyright © 2017. Published by Elsevier Masson SAS.

  16. [Nine-Year Experience after ISO 15189 Acquisition, How Successful was It? Focusing on the Results of Interviews and Questionnaires].

    Science.gov (United States)

    Fujimoto, Kazumitsu; Asai, Noriaki; Nakajima, Yoshinaga; Inoue, Kaoru

    2015-11-01

    Our laboratory, for the purpose of Quality Management System (QMS) improvement, acquired ISO 15189:2003 accreditation 9 years ago and completed the renewal to ISO 15189:2012 last year. In this study, we reviewed the efficacy of ISO 15189 based on an analysis of laboratory director's and managers' opinions. We could realize QMS improvement through the proactive implementation of preventive and corrective actions, and also the continuous implementation of education and delivery by means of reviewing the interview records of ISO 15189:2012 renewal with the laboratory director. All answers to the questionnaire obtained from managers with regard to the advantages of ISO 15189 acquisition agreed with the purpose of ISO 15189. From these results, we concluded that ISO 15189 acquisition was successful for QMS improvement. [Review].

  17. Management system quality of service radio physics and RR. ISO 9001

    International Nuclear Information System (INIS)

    Gil Agudo, A.; Torres Donaire, J.; Jimenez, J. C.; Carrascosa Fernandez, C.; Arjona Gutierrez, J.

    2011-01-01

    One of the tool increasingly deployed for the optimization of the procedures is the process management system according to a Quality Management. Likewise, for specific areas, such as central services within large institutions such as the General Hospitals of the systems of quality management is the most widely used ISO 9001. We describe in this paper our experience in implementing the system ISO 9001 in our Department of Radio physics and Radiation Protection (SRFPR).

  18. ncISO Facilitating Metadata and Scientific Data Discovery

    Science.gov (United States)

    Neufeld, D.; Habermann, T.

    2011-12-01

    Increasing the usability and availability climate and oceanographic datasets for environmental research requires improved metadata and tools to rapidly locate and access relevant information for an area of interest. Because of the distributed nature of most environmental geospatial data, a common approach is to use catalog services that support queries on metadata harvested from remote map and data services. A key component to effectively using these catalog services is the availability of high quality metadata associated with the underlying data sets. In this presentation, we examine the use of ncISO, and Geoportal as open source tools that can be used to document and facilitate access to ocean and climate data available from Thematic Realtime Environmental Distributed Data Services (THREDDS) data services. Many atmospheric and oceanographic spatial data sets are stored in the Network Common Data Format (netCDF) and served through the Unidata THREDDS Data Server (TDS). NetCDF and THREDDS are becoming increasingly accepted in both the scientific and geographic research communities as demonstrated by the recent adoption of netCDF as an Open Geospatial Consortium (OGC) standard. One important source for ocean and atmospheric based data sets is NOAA's Unified Access Framework (UAF) which serves over 3000 gridded data sets from across NOAA and NOAA-affiliated partners. Due to the large number of datasets, browsing the data holdings to locate data is impractical. Working with Unidata, we have created a new service for the TDS called "ncISO", which allows automatic generation of ISO 19115-2 metadata from attributes and variables in TDS datasets. The ncISO metadata records can be harvested by catalog services such as ESSI-labs GI-Cat catalog service, and ESRI's Geoportal which supports query through a number of services, including OpenSearch and Catalog Services for the Web (CSW). ESRI's Geoportal Server provides a number of user friendly search capabilities for end users

  19. Development of international standards for surface analysis by ISO technical committee 201 on surface chemical analysis

    International Nuclear Information System (INIS)

    Powell, C.J.

    1999-01-01

    Full text: The International Organization for Standardization (ISO) established Technical Committee 201 on Surface Chemical Analysis in 1991 to develop documentary standards for surface analysis. ISO/TC 201 met first in 1992 and has met annually since. This committee now has eight subcommittees (Terminology, General Procedures, Data Management and Treatment, Depth Profiling, AES, SIMS, XPS, and Glow Discharge Spectroscopy (GDS)) and one working group (Total X-Ray Fluorescence Spectroscopy). Each subcommittee has one or more working groups to develop standards on particular topics. Australia has observer-member status on ISO/TC 201 and on all ISO/TC 201 subcommittees except GDS where it has participator-member status. I will outline the organization of ISO/TC 201 and summarize the standards that have been or are being developed. Copyright (1999) Australian X-ray Analytical Association Inc

  20. PENGEMBANGAN DAN ANALISIS KUALITAS APLIKASI PENILAIAN E-LEARNING SMK BERBASIS ISO 19796-1 DI YOGYAKARTA

    Directory of Open Access Journals (Sweden)

    Ahmad Faiq Abror

    2016-03-01

    Full Text Available Penelitian ini bertujuan untuk: (1 menghasilkan aplikasi penilaian e-learning Sekolah Menengah Kejuruan (SMK berbasis ISO 19796-1 yang dapat digunakan untuk mengevaluasi e-learning SMK di Yogyakarta menggunakan teknik Analitycal Hierarchy Process (AHP dengan metode agregasi arithmetric mean dan geometric mean, (2 menguji kualitas aplikasi dengan menggunakan strandar ISO 9126. Penelitian ini merupakan penelitian Research and Development (R&D. Proses pengembangan aplikasi menggunakan metode  Software Development Life Cycle (SDLC dengan model Waterfall. Selanjutnya pada proses pengujian kualitas aplikasi menggunakan standar ISO 9126 yang terdiri atas aspek functionality, reliability, efficiency, maintainability, usability, dan portability. Hasil penelitian menunjukkan bahwa aplikasi penilaian e-learning SMK berdasarkan ISO 19796-1 telah berhasil dikembangkan menggunakan metode Software Development Life Cycle (SDLC dengan model waterfall. Selanjutnya hasil dari analisis kualitas aplikasi menggunakan standar ISO 9126 menunjukkan bahwa aplikasi mempunyai hasil rata-rata sangat baik dan layak digunakan untuk penilaian kualitas e-learning SMK.

  1. 78 FR 38027 - ISO New England Inc.; Notice of Initiation of Proceeding and Refund Effective Date

    Science.gov (United States)

    2013-06-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL13-72-000] ISO New England... III.A.15 of Appendix A of ISO New England Inc.'s existing tariff. Dominion Energy Marketing, Inc. and ISO New England Inc., 143 FERC ] 61,233 (2013). The refund effective date in Docket No. EL13-72-000...

  2. Quality control with R an ISO standards approach

    CERN Document Server

    Cano, Emilio L; Prieto Corcoba, Mariano

    2015-01-01

    Presenting a practitioner's guide to capabilities and best practices of quality control systems using the R programming language, this volume emphasizes accessibility and ease-of-use through detailed explanations of R code as well as standard statistical methodologies. In the interest of reaching the widest possible audience of quality-control professionals and statisticians, examples throughout are structured to simplify complex equations and data structures, and to demonstrate their applications to quality control processes, such as ISO standards. The volume balances its treatment of key aspects of quality control, statistics, and programming in R, making the text accessible to beginners and expert quality control professionals alike. Several appendices serve as useful references for ISO standards and common tasks performed while applying quality control with R.

  3. Integración de las normas ISO 9001 e ISO INEN 22716 en la metodología apropiada con la industria de cosméticos de Quito

    OpenAIRE

    Mora Quishpe, Juan Carlos

    2015-01-01

    The following research the integration of ISO 9001: 2008 "Quality Management Systems" INEN and ISO 22716: 2013 "Cosmetics Good Manufacturing Practices" in an appropriate methodological guide to the cosmetics industry Quito, in order for organizations that manufacture cosmetics in the city, improve the quality of their products. Initially the diagnosis of the cosmetic was held in Quito, with regard to the number of manufacturers of these industries registered by the National Health Authorit...

  4. Mapping ‘hydroscapes’ along the iso- to anisohydric continuum of stomatal regulation of plant water status

    Science.gov (United States)

    Frederick C. Meinzer; David R. Woodruff; Danielle E. Marias; Duncan D. Smith; Katherine A. McCulloh; Ava R. Howard; Alicia L. Magedman; Josep Penuelas

    2016-01-01

    The concept of iso- vs. anisohydry has been used to describe the stringency of stomatal regulation of plant water potential (ψ). However, metrics that accurately and consistently quantify species’ operating ranges along a continuum of iso- to anisohydry have been elusive. Additionally, most approaches to quantifying iso/anisohydry require labour-intensive measurements...

  5. [ISO 15189 accreditation in clinical microbiology laboratory: general concepts and the status in our laboratory].

    Science.gov (United States)

    Akyar, Işin

    2009-10-01

    One important trend in the laboratory profession and quality management is the global convergence of laboratory operations. The goal of an accredited medical laboratory is to continue "offering useful laboratory service for diagnosis and treatment of the patients and also aid to the health of the nation". An accredited clinical laboratory is managed by a quality control system, it is competent technically and the laboratory service meets the needs of all its patients and physicians by taking the responsibility of all the medical tests and therapies. For this purpose, ISO 15189 international standard has been prepared by 2003. ISO 15189 standard is originated from the arrangement of ISO 17025 and ISO 9001:2000 standards. Many countries such as England, Germany, France, Canada and Australia have preferred ISO 15189 as their own laboratory accreditation programme, meeting all the requirements of their medical laboratories. The accreditation performance of a clinical microbiology laboratory is mainly based on five essential points; preanalytical, analytical, postanalytical, quality control programmes (internal, external, interlaboratory) and audits (internal, external). In this review article, general concepts on ISO 15189 accreditation standards for the clinical microbiology laboratories have been summarized and the status of a private laboratory (Acibadem LabMed, Istanbul) in Turkey has been discussed.

  6. EFEKTIVITAS PENGOPERASIAN INSTALASI PENGOLAH AIR LIMBAH (IPAL PERUSAHAAN PERAIH SERTIFIKASI ISO 14001 DI KAWASAN SIMONGAN KOTA SEMARANG (The Effectivity of Waste Water Treatment Plan Operated by Industrial Companies Holding ISO 14001 Certificate

    Directory of Open Access Journals (Sweden)

    Zaenuri Zaenuri

    2012-07-01

    Full Text Available ABSTRAK Penelitian ini bertujuan untuk menganalisis efektivitas pengoperasian instalasi pengolah air limbah (IPAL perusahaan peraih sel1ifikasi ISO 14001 di Kawasan Simongan Kota Semarang. Data yang diperoleh dianalisis secara deskriptif-komparatif dan inferensial dengan menggunakan uji-t. Hasil penelitian menunjukkan, pada perusahaan farmasi, rata-rata konsentrasi TSS, BOD, dan COD periode 1989-1998 (sebelum memperoleh ISO 14001 masing-masing sebesar 92,3229 mg/I, 45,5022 mg/I, dan 87,3691 mg/I, sedangkan rata-rata pH sebesar 7,2388. Parameter BOD dan COD memenuhi baku mutu, pH dalam interval baku mutu yang ditetapkan, sedangkan TSS berada di atas baku mutu. ABSTRACT This research was intended to analyze the effectivity of  waste water treatment plan operated by industrial companies holding ISO 14001 certificates in Simongan Area of SemarangCity. The data were analyzed descriptively, comparatively and inferentially using t-tests. The analyses showed that prior to obtaining ISO 14001 certificate (1989-1998, the pharmaeutical company had its average concentrations of TSS, BOD, and COD of 92.3229, 45.5022 and 87.3691 mg/l respectively, with an average pH of 7.2388. These parameters of BOD and COD had already met the prevailing standard qualities, the TSS parameter was above the standard quality, and the pH was within the prevailing standard quality interval. After obtaining the ISO 14001 certificate (2005-2008, this pharmaeutical company was able to maintain all of the key parameters to meet the prevailing stadard qualities. In case of the galvanizing company prior to obtaining ISO 14001 certificate (1989-1998, its average concentrations of TSS and CN were 256.3469 and 0.25575 mg/l respectively (above the prevailing standard qualities, those for total Cr, C+6, Cu, Zn, Ni, and Pb were 0.0510, 0.0036, 0.236060, 0.7242, 0.01790 and 0.0286 mg/l respectively (still under the prevailing standard qualities, while the an average pH was within the

  7. Analysis of the Environmental Management System based on ISO 14001 on the American continent.

    Science.gov (United States)

    Neves, Fábio de Oliveira; Salgado, Eduardo G; Beijo, Luiz A

    2017-09-01

    The American continent is in broad economic and industrial development. Consequently, a more detailed discussion of the impacts generated by such development is needed. Moreover, there is an increase in the number of ISO 14001 certificates issued to this continent. Given the above, no studies were found that bridge the gap to identify the influence of different factors on ISO 14001 in the Americas. Thus, this article has as its main aim to check which economic, environmental and cultural factors have influence on ISO 14001 Certification in the American Continent. The data were collected in the ISO Survey, World Bank, United Nations Development Programme and International Energy Agency. Among the countries of that continent, thirteen were analyzed and only two did not show the economic factors as the influence factor in the multiple regression models fitted with Brazil and the United State. In these models, all presented environmental factors as influencing factors. Only in Brazil the index HDI presented as cultural factor in multiple regression model fitted. The economic factors: Gross Domestic Product and exports of goods and services and environmental: Carbon Dioxide (CO 2 ) and fossil fuel consumption were the most influential in ISO 14001 certification. Venezuela, Uruguay, Colombia and the United States were countries that had factors dependent on each other, featuring the environmental marketing. Briefly, this study brings up several implications: to the academy, with the proposal of new concepts and guidance on the factors that assist in ISO 14001 certification in the American Continent. Additionally, taking into account the industry, the factors serve as efficiency parameters for the implementation of ISO 14001 standard, and for the Government to improve through factors that do not fit in multiple regression models. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Plan de implementación de la ISO/IEC 27001:2013

    OpenAIRE

    Gorriti Aranguren, Iñaki

    2015-01-01

    En el desarrollo del proyecto se analizaron las directrices establecidas en la norma ISO/IEC 27001:2013, que especifica los requisitos necesarios para establecer, implantar, mantener y mejorar un SGSI mediante un proceso de mejora continua. In the development there were analyzed the directives established in the norm ISO/IEC27001:2013, which specifies the necessary requirements to establish, to implement, to support and to improve a SGSI by means of a process of constant improvement. En...

  9. Iso-acoustic focusing of cells for size-insensitive acousto-mechanical phenotyping.

    Science.gov (United States)

    Augustsson, Per; Karlsen, Jonas T; Su, Hao-Wei; Bruus, Henrik; Voldman, Joel

    2016-05-16

    Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling assessment of effective parameters relating to cells' interior molecular content and structure. Here, we present iso-acoustic focusing, an equilibrium method to analyze the effective acoustic impedance of single cells in continuous flow. While flowing through a microchannel, cells migrate sideways, influenced by an acoustic field, into streams of increasing acoustic impedance, until reaching their cell-type specific point of zero acoustic contrast. We establish an experimental procedure and provide theoretical justifications and models for iso-acoustic focusing. We describe a method for providing a suitable acoustic contrast gradient in a cell-friendly medium, and use acoustic forces to maintain that gradient in the presence of destabilizing forces. Applying this method we demonstrate iso-acoustic focusing of cell lines and leukocytes, showing that acoustic properties provide phenotypic information independent of size.

  10. Effective energy management system using ISO 9000/14000 concept industries

    International Nuclear Information System (INIS)

    Asfaazam Kasbani; Kamaruzzaman Sopian

    2006-01-01

    Energy management is a system of managing energy utilization wisely and it includes issues such as energy efficiency (conservation), use of renewable energy, use of technology and development of energy policy. Its benefits has been well known for cost reduction and increase competitiveness and also other indirect impact such as preserving the natural resources and reduction of green-house gases. Although various strategies have been formulated by the government for the industries to adopt energy management, the result seems to be minimal and stagnant in some ways due to the various barriers which exists. Industries on the other hand, have successfully welcomed two famous management system namely the Environmental Management System ISO 14000 and the Quality Management System ISO 9000 to be implemented at their premises. This paper shows how energy management system can be effectively implemented by comparing similar generic management elements of energy management to ISO 9000/14000 standards. The seven (7) elements of energy management system discussed are top management commitment, policy establishment, energy management team, energy audit, energy efficiency projects, monitoring and training

  11. ISOS: A job evaluation system to implement comparable worth

    Directory of Open Access Journals (Sweden)

    Albert Corominas

    2008-01-01

    Full Text Available A fair pay structure is an essential element of the personnel policy of a firm. If the pay structure is perceived as arbitrary by the members of the staff, it becomes a cause of disturbance of the labor relations. Particularly, a pay structure is unfair if it discriminates against women. Job evaluation is a traditional tool used by companies to assist in the process of determining pay structures that can be also useful to detect and combat wage discrimination, since allow determining whether two jobs are of comparable worth or not. Although there are many kinds of systems, authors agree when defining point factor methods as the most appropriate and fair job evaluation systems. However, even being well defined from a technical point of view, most existing systems give discriminatory results regarding to gender. ISOS, a new job evaluation system which is described in this paper, has been designed, with the aim to define a neutral system with regard to gender, based on present jobs characteristics, existing job evaluation systems and job description questionnaires, international experts’ knowledge and a wide body of literature on gender discrimination and its relation with job evaluation. Using ISOS can contribute to detect, combat and eliminate part of the existing wage discrimination in general and, in particular, against women. ISOS includes all aspects of the work so no characteristics are omitted. The system can be applied in any company and to evaluate any job, and offers flexibility to be adapted to the specific characteristics of an organization. ISOS can also be used to detect and combat wage discrimination. Furthermore, characteristics of present jobs, such as cross-training or flexible working time, are also included so the system can be considered innovative in a very traditional field of industrial engineering.

  12. Can the ISO-standards on quality management be useful to libraries and how?

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav

    1994-01-01

    The aim of this paper is to discuss whether the ISO 9000 concept of quality assurance is useful in a library context or not. First, the basics of the ISO 9000 series are explained. Then, the nature of the concept is discussed and the critical views raised by quality management experts are reviewed...... concluded that the whole discussion on ISO 9000 seems a little futile because the real critical success factor for libraries aiming at Total Quality does not seem to lie in the choice of a specific quality model or guru but more is a question of commitment project on quality assurance in special libraries...

  13. Correlating the content and context of PAS 55 with the ISO 55000 series

    Directory of Open Access Journals (Sweden)

    Van den Honert, A. F.

    2013-08-01

    Full Text Available The ISO 55000 series is soon to supersede PAS 55 as the most recognised international standard for asset management. A correlation of the content and context of PAS 55 with the ISO 55000 series is required to assist organisations with the transition. After analysis of the structures, similarities, differences, and omissions of the two standards, a map was created to correlate the summarised content and context. The map established that, although both sets of standards have a similar structural framework, the ISO 55000 series is a more comprehensive and detailed standard, creating a clearer way to implement an asset management system within an organisation.

  14. ISO Key Project: Exploring the Full Range of Quasar/Agn Properties

    Science.gov (United States)

    Wilkes, Belinda; Oliversen, Ronald J. (Technical Monitor)

    2003-01-01

    While most of the work on this program has been completed, as previously reported, the portion of the program dealing with the subtopic of ISO LWS data analysis and reduction for the LWS Extragalactic Science Team and its leader, Dr. Howard Smith, is still active. This program in fact continues to generate results, and newly available computer modeling has extended the value of the datasets. As a result the team requests a one-year no-cost extension to this program, through 31 December 2004. The essence of the proposal is to perform ISO spectroscopic studies, including data analysis and modeling, of star-formation regions using an ensemble of archival space-based data from the Infrared Space Observatory's Long Wavelength Spectrometer and Short Wavelength Spectrometer, but including as well some other spectroscopic databases. Four kinds of regions are considered in the studies: (1) disks around more evolved objects; (2) young, low or high mass pre-main sequence stars in star-formation regions; (3) star formation in external, bright IR galaxies; and (4) the galactic center. One prime focus of the program is the OH lines in the far infrared. The program has the following goals: 1) Refine the data analysis of ISO observations to obtain deeper and better SNR results on selected sources. The ISO data itself underwent 'pipeline 10' reductions in early 2001, and additional 'hands-on data reduction packages' were supplied by the ISO teams in 2001. The Fabry-Perot database is particularly sensitive to noise and slight calibration errors; 2) Model the atomic and molecular line shapes, in particular the OH lines, using revised Monte-Carlo techniques developed by the SWAS team at the Center for Astrophysics; 3) Attend scientific meetings and workshops; 4) Perform E&PO activities related to infrared astrophysics and/or spectroscopy.

  15. EFFICIENCY OF ISO 9001 IN PORTUGAL: A QUALITATIVE STUDY FROM A HOLISTIC THEORETICAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Alcina Dias

    2013-03-01

    Full Text Available The purpose of this paper is to analy se the efficiency of ISO 9001 from a holistic theoretical approach where the Contingency theory, the Institutional theory and the Resources-Based View are integrated. The study was carried out in companies of different sectors of activity in Portugal, based on a qualitative methodology (interviews. The fact of the interviews having been undertaken under an ISO 9001 structure made it easier for companies to grasp the issues under investigation. An ISO 9001 characterisation was carried out on a theoretical framework approach and findings point out efficiency gains and revealed that the absence of ISO 9001 would work as a competitive disadvantage. The contribution of this research aims to reinforce the state of art as concerns the theoretical scope of analysis of these issues enriched by the case study achievement.

  16. Partial replacement of fish meal by T-Iso in gilthead sea bream (Sparus aurata juveniles diets

    Directory of Open Access Journals (Sweden)

    Ivo Zoccarato

    2010-01-01

    Full Text Available The aim of this study was the evaluation of microalga Isochrysis sp. T-Iso in partial substitution of fish meal and the study of the effects on gilthead sea bream (Sparus aurata perform- ances and chemical composition of fillets. The results show that the microalga T-Iso nutrients support growth better than control diets, and the chemical composition of sea bream fillets also meets the needs of consumers for healthy diets. T-Iso resulted highly digestible, and support the best perform- ances of fish fed on 70% alga diet probably due to its high protein efficiency in comparison to other diets. The presence of a high quantity of cyclic isoprenoid could explain this high efficiency of T-Iso. Gilthead sea bream fed on 70% T-Iso showed fillets with a low level of protein and a high level of fat; moreover, their somatic indexes were higher than those of fish fed other diets. Highest percentage T- Iso diet showed the highest amount of the sum of saturated fatty acids, mainly due to myristate and palmitate. On the contrary, the sum of polyunsaturated decreases, mainly because of the reduction of EPA and DHA amounts. If the mass production economical problems are solved, T-Iso will represent a good solution in partial substitution of fish meal.

  17. Essence of demands of standard ISO 22000:2005 in aspect of assurances of milk health safety Istota wymagań standardu ISO 22000:2005 w aspekcie zapewnienia bezpieczeństwa zdrowotnego mleka

    Directory of Open Access Journals (Sweden)

    Justyna Górna

    2008-09-01

    Full Text Available The article presents the essence of demands of ISO 22000 as a standard which allows of control milk health safety in a more effective way. The implementation of system HACCP in the dairy companies undoubtedly make for more safety health products, however microbiological research of pasterized milk shows that it is scarce. The elementary advantage for organization which comes from food quality management system meeting demands included in standard ISO 22000 is undoubtedly assurance of legal demands concerning production of food safety and more effective control of risk of food safety. The dairy companies should aspire for implementation of more rigorous standard ISO 22000:2005.

  18. ISO in the Construction and Manufacturing Companies: A Case Study from the Construction Industry of Hyderabad and Karachi, Pakistan

    Directory of Open Access Journals (Sweden)

    Nafees Ahmed Memon

    2011-04-01

    Full Text Available Construction industry plays very important role in development of any country. The development of construction industry depends to a larger extent on quality of construction productions and projects. Quality of construction productions and projects is linked with the implementation of QMS (Quality Management System in construction organizations. ISO certification is one of the QMS which has been adopted in manufacturing and construction industry at the global level. The construction companies of developing countries have reaped many advantages from the effective implementation of ISO standards. The rate of adoption of ISO standards has remained slow in the construction sector of some developing countries like Pakistan. This paper presents the literature review of ISO in global construction industry. It highlights the advantages, disadvantages and barriers faced by construction companies in the implementation of ISO standards. This study also investigates the level of adoption of ISO standards in construction and manufacturing companies of Pakistan through a questionnaire survey. It presents the comparison of ISO standards\\\\\\' adoption in both construction and manufacturing sectors. The paper puts forward some suggestions and recommendation for the better adoption and improvement of ISO implementation in the construction sector of Pakistan. This study emphasizes that construction companies of Pakistan should learn from the benefits reaped by the construction companies of developed countries and take appropriate measures for implementing ISO standards. It also suggests that public sector clients should make it obligatory for the contractors and consultants to have ISO certification before awarding the works in order to enhance the the adoption of ISO standards in construction sector.

  19. Impact of 50% Synthesized Iso-Paraffins (SIP) on F-76 Fuel Coalescence

    Science.gov (United States)

    2013-12-16

    petroleum JP-5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic...manufactured scaled down filter/coalescer and separator to simulate the performance of a full-scale filter separator system. This test is designed to predict...5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic hydrocarbons

  20. Quality assurance standards: comparison between IAEA 50-C/SG-Q and ISO 9001:1994

    International Nuclear Information System (INIS)

    2000-11-01

    The International Atomic Energy Agency (IAEA) and the International Organization for Standardization (ISO) agreement regarding the scope and coverage of documents published by both organizations points out that the standards of safety developed by the IAEA are recommendations for use by its Member States in the framework of national regulations for the safe utilization of nuclear energy. Such standards should be considered as nuclear safety regulatory documents. The standards developed by the ISO are complementary technical documents emphasizing industrial application and contractual aspects. Regarding the quality assurance topic, the IAEA standards 50-C/SG-Q are mostly used directly or indirectly to establish the nuclear safety requirements at the utility-regulatory interface. The industrial ISO 9001 standards have progressively been used to implement the quality assurance requirements at the interface utility-supplier. The relationship between both standards is growing in significance owing to the impact upon the owners/operators of nuclear facilities and their contractors/suppliers. The relationship between the IAEA and ISO standards is considered critical, in particular regarding suppliers with a small range of nuclear supplies. These organizations are not always willing to prepare special quality assurance programmes based on nuclear safety standards. On the other hand, these organizations may be qualified on the basis of the ISO quality assurance standards. In any case, for delivering nuclear items and services the quality assurance programme must comply with the requirements established in the nuclear safety regulatory standards. This implies that the utility-supplier will have to demonstrate that the acceptable degree of quality assurance in relation to nuclear safety is accomplished. This may be achieved by imposing additional requirements on the supplier over and above those contained within the ISO. In order to provide a description of the differences

  1. Bahan pemutih gigi dengan sertifikat ADA/ISO (Tooth bleaching material with ADA/ISO certificate

    Directory of Open Access Journals (Sweden)

    Asti Meizarini

    2005-06-01

    Full Text Available Bleaching of teeth for cosmetic reasons is a popular aspect of cosmetic dentistry because patients realize the aesthetical benefits of these products. The dentist as a clinician's practitioner must be knowledgeable of the products and their application techniques. Bleaching materials which are safe and effective are the ADA accepted or manufactured by those which have already haved ISO certificate. Dentist must have enough knowledge about in-office bleaching prescribed for home-use bleaching including their contra indication and side effects, to advise the patients and provide effective bleaching services.

  2. 76 FR 7839 - Notice of Commission and Commission Staff Attendance at ISO/RTO Council and Regional State...

    Science.gov (United States)

    2011-02-11

    ... Staff Attendance at ISO/RTO Council and Regional State Committees Meeting The Federal Energy Regulatory... ISO/RTO Council and Regional State Committees meeting: Saturday, February 12, 2011, 1 p.m.-4 p.m... following proceeding: Docket No. AD10-5-000, RTO/ISO Performance Metrics. For more information, contact...

  3. A primer on the Petri Net Markup Language and ISO/IEC 15909-2

    DEFF Research Database (Denmark)

    Hillah, L. M.; Kindler, Ekkart; Kordon, F.

    2009-01-01

    Standard, defines a transfer format for high-level nets. The transfer format defined in Part 2 of ISO/IEC 15909 is (or is based on) the \\emph{Petri Net Markup Language} (PNML), which was originally introduced as an interchange format for different kinds of Petri nets. In ISO/IEC 15909-2, however...

  4. Strategy for infrared photometry of comets with ISO

    Science.gov (United States)

    Solc, M.; Vanysek, V.; Gruen, E.

    1994-07-01

    The launch of the ISO (Infrared Satellite Observatory) by the European Space Agency is scheduled for autumn 1995. Photometry and spectrophotometry observing programs of comets in the wavelength range 2.5-200 microns for the onboard spectrophotometer ISOPHOT is now under final preparation. Technical details for preparing propasals are given. Phenomena in comets to be studied are surface properties of bare cometary nuclei at large heliocentric distances, onset of coma activity, and coma dust and gas emission (in inner solar system). Dust production, dust/gas mass ratio, dust distribution in coma, and their temporal variability are important for understanding the physical processes on nuclei, and spectrophotometry in the range of 2.5-12 microns could provide us with data of the chemical composition of cometary dust. Several active comets expected for the 18-month lifetime of ISO in 1995-1997 were selected for the ISO Central Program according to their orbital and physical parameters: P/Schwassman-Wachmann 1, P/Encke, P/d'Arrest, P/Honda-Mrkos-Pajdusakova, P/Churyumov-Gerasimenko, P/Kopff, P/IRAS, P/Wirtanen, P/Wild 2, P/Grigg-Skjellerup, P/Schwassman-Wachmann 3, P/Machholz, and (2060) Chiron. Four of them match well various constraints put on the observations by the technical arrangement of the satellite and instrument. A simple four-parameter model (size, albedo, rotation, optical thickness)was developed to estimate the temperatures and thermal fluxes of both solid nuclei and dust coma.

  5. Some considerations on the trunk Simulator ISO: experience in manufacturing, use and maintenance; Algumas consideracoes sobre o simulador de tronco da ISO: experiencia em fabricacao, uso e manutencao

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Marcelo M.; Mauricio, Claudia L.P., E-mail: marcelo@ird.gov.br, E-mail: claudia@ird.gov.br [Instituto de Radioprotecao e Dosimetria (lRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    To standardize the operational quantity H{sub p}(10), ISO defined a water slab phantom. The conversion factors from air kerma to individual dose equivalent, H{sub p}(10), for photon radiation are tabulated in ISO 4037-3, and from neutron fluence 10 H{sub p}(10) in ISO 8529-3. This paper presents some considerations concerning the manufacture, use and maintenance of seven ISO water slab phantoms. The experience of the IRD in manufacturing (in its own Mechanical Workshop) and keeping these phantoms and the main advantages and problems encountered during more than 10 years of heavy use, especially for neutron dosimetry, are fully described. An important consideration regarding the interior of the phantom relates to internal cleanliness and quality of the water used to fill it. Another is about the positioning of multiple monitors on a single simulator, including irradiation angles, and the possibility of using multi pie phantoms for isotropic irradiation fields. Finally, it is presented the problems occurred in some phantoms, such as leaks and how to fix them. The two older phantoms, employed exclusively in neutron irradiation, have visible trails of damage in polymethylmethacrylate (PMMA), converging towards its centre, along its front wall, making it more fragile. This is caused by the interaction of radiation with the PMMA. (author)

  6. Managing your library and its quality the ISO 9001 way

    CERN Document Server

    Balagué, Núria

    2011-01-01

    This book, divided into two parts, provides an introduction to the quality management issues and gives a general overview to the use of ISO 9001 in the library environment. The second part presents the main features of ISO 9001:2008 with practical comments and examples on how to implement its clauses in libraries. Whether in the public or in the private sector, libraries can be seen as service organisations: they act in very dynamic environments where users are increasingly demanding new types of services. Thus the adoption of a quality management system helps each library in meeting the needs

  7. Uvedba standarda ISO 9000 ter zadovoljstvo udeležencev nabavne verige = The ISO 9000 Implementation and Satisfaction of the Participants in the Supply Chain

    Directory of Open Access Journals (Sweden)

    Armand Faganel

    2007-06-01

    Full Text Available There have been written many articles about business performance, regarding the influence of ISO 9000 standards, proving the beneficial effects. However, there has been very little research made on the influence of ISO standards an the entire supply chain management. Standards have been mostly introduced into companies due to the demands of customers. But once the company has implemented the ISO philosophy, it produces a chain reaction up and down the supply chain. The customer-supplier relationship becomes more solid, trust and transparency are proliferating across the supply chain. One of the important supply chain management influences is the cooperation of companies, with the common goal of increasing the channel sales and profitability, rather than competing for a larger slice of fixed profit. We made a research with 212 certificated Slovenian companies. The standard improved the performance of supply function and the process of choosing the suppliers. If the companies can make good use of the standard, there are many opportunities in the field of approach improvement to the suppliers. Companies with longer use of the standard have achieved greater impact with the quality of supplies, suppliers responsiveness, punctuality and affidability.

  8. Experimental investigation on SI engine using gasoline and a hybrid iso-butanol/gasoline fuel

    International Nuclear Information System (INIS)

    Elfasakhany, Ashraf

    2015-01-01

    Highlights: • iso-Butanol–gasoline blends (iB) using up to 10 vol.% butanol were examined in SIE. • iB extensively decrease the greenhouse effect of SI engine. • iB without engine tuning led to a drop in engine performance at all speeds. • iB provide higher performance and lower CO and CO 2 emissions than n-butanol blends. • iB grant lower CO and UHC than gasoline at <2900 r/min, but overturn at >2900 r/min. - Abstract: Experimental investigation on pollutant emissions and performance of SI engine fueled with gasoline and iso-butanol–gasoline blends is carried out. Engine was operated at speed range of 2600–3400 r/min for each blend (3, 7 and 10 vol.% iso-butanol) and neat gasoline. Results declare that the CO and UHC emissions of neat gasoline are higher than those of the blended fuels for speeds less than or equal to 2900 r/min; however, for speeds higher than 2900 r/min, we have an opposite impact where the blended fuels produce higher level of CO and UHC emissions than the gasoline fuel. The CO 2 emission at using iso-butanol–gasoline blends is always lower than the neat gasoline at all speeds by up to 43%. The engine performance results demonstrate that using iso-butanol–gasoline blends in SI engine without any engine tuning lead to a drop in engine performance within all speed range. Without modifying the engine system, overall fuel combustion of iso-butanol–gasoline blends was quasi-complete. However, when engine system is optimized for blended fuels, iso-butanol has significant oxygen content and that can lead to a leaner combustion, which improves the completeness of combustion and therefore high performance and less emissions would be obtained. Finally, the performance and emissions of iso-butanol–gasoline blends are compared with those of n-butanol–gasoline blends at similar blended rates and engine working conditions. Such comparison is directed to evaluate the combustion dissimilarity of the two butanol isomers and also to

  9. Contrasting predictability of summer monsoon rainfall ISOs over the northeastern and western Himalayan region: an application of Hurst exponent

    Science.gov (United States)

    Mukherjee, Sandipan

    2017-09-01

    Due to heterogeneous nonlinear forcing of complex geomorphological features, predictability of monsoon rainfall 10-90-day intra-seasonal oscillations (ISO) over the complex terrain of northeastern and western Himalayan region (NEH and WH) remained poorly quantified. Using 72 and 61 number of station observations of monsoon rainfall ISOs of NEH and WH, respectively, this study attempts to investigate variation in the regional scale predictability of monsoon rainfall ISOs with respect to changing geomorphological features and monsoon rainfall characteristics. In view of the bimodal nonlinear dynamical structure of monsoon rainfall ISO, the fractal dynamical Hurst exponent-based predictability indices are estimated as an indicator of predictability for station observations of NEH and WH, and relationships with elevations, slopes, aspects, and average numbers of occurrences of long (short) spell of active (break) phases are investigated. Results show 10-90-day ISOs are anti-persistent throughout the IHR, although, predictability of 10-90-day ISOs is higher over the NEH region than WH. Predictabilities of ISOs are found to decrease with increasing elevation and slope for both NEH and WH regions. Predictabilities of ISOs over both regions are also found to increase linearly as the number of occurrences of monsoon rainfall ISO phases (active/break) increases.

  10. A formal analysis of ISO/IEEE P11073-20601 standard of medical device communication

    NARCIS (Netherlands)

    Goga, Nicolae; Costache, Stefania; Moldoveanu, Florica

    2009-01-01

    This article presents the formal work done for the ISO/IEEE P11073-20601 Draft Standard for Health informatics - Personal health device communication - Application profile Optimized exchange protocol. ISO/IEEE 11073 family defines standards for device communication between agents (e.g. blood

  11. 75 FR 3225 - Notice of Commission Staff Attendance at Organization of MISO States and Midwest ISO Meetings

    Science.gov (United States)

    2010-01-20

    ... Organization of MISO States and Midwest ISO Meetings January 12, 2010. The Federal Energy Regulatory Commission...: Midwest ISO Headquarters, 720 City Center Drive, Carmel, IN 46032. Except as otherwise noted above, the... Operator, Inc. Docket No. ER08-15, Midwest ISO Transmission Owners Docket No. ER08-55, Midwest Independent...

  12. Analysis of ISO/IEC 17025 for establishment of KOLAS (Korea Laboratory Accreditation Scheme) quality assurance system

    International Nuclear Information System (INIS)

    Nam, Ji Hee

    2000-12-01

    Besides one existent accredited lab, radioactive material chemical analysis lab, five test laboratories and two calibration labs are under plan to acquire the accreditation from KOLAS. But the current Quality Manual was developed according to ISO Guide 25 that was superceded by ISO/IEC 17025. Since it is tailored to the radioactive material chemical analysis lab, a number of requirements of the Manual are not applicable to the labs other than radioactive material chemical analysis lab. Through the analysis of ISO/IEC 17025, a model of quality system was established which is not only consistent with ISO/IEC 17025 but reflective of the KAERI's situation

  13. Characterization of Slosh Damping for Ortho-Grid and Iso-Grid Internal Tank Structures

    Science.gov (United States)

    Westra, Douglas G.; Sansone, Marco D.; Eberhart, Chad J.; West, Jeffrey S.

    2016-01-01

    Grid stiffened tank structures such as Ortho-Grid and Iso-Grid are widely used in cryogenic tanks for providing stiffening to the tank while reducing mass, compared to tank walls of constant cross-section. If the structure is internal to the tank, it will positively affect the fluid dynamic behavior of the liquid propellant, in regard to fluid slosh damping. As NASA and commercial companies endeavor to explore the solar system, vehicles will by necessity become more mass efficient, and design margin will be reduced where possible. Therefore, if the damping characteristics of the Ortho-Grid and Iso-Grid structure is understood, their positive damping effect can be taken into account in the systems design process. Historically, damping by internal structures has been characterized by rules of thumb and for Ortho-Grid, empirical design tools intended for slosh baffles of much larger cross-section have been used. There is little or no information available to characterize the slosh behavior of Iso-Grid internal structure. Therefore, to take advantage of these structures for their positive damping effects, there is much need for obtaining additional data and tools to characterize them. Recently, the NASA Marshall Space Flight Center conducted both sub-scale testing and computational fluid dynamics (CFD) simulations of slosh damping for Ortho-Grid and Iso-Grid tanks for cylindrical tanks containing water. Enhanced grid meshing techniques were applied to the geometrically detailed and complex Ortho-Grid and Iso-Grid structures. The Loci-STREAM CFD program with the Volume of Fluid Method module for tracking and locating the water-air fluid interface was used to conduct the simulations. The CFD simulations were validated with the test data and new empirical models for predicting damping and frequency of Ortho-Grid and Iso-Grid structures were generated.

  14. Management system quality of service radio physics and RR. ISO 9001; Sistema de gestion de la calidad de un servicio de radiofisica y P. R. segun ISO 9001

    Energy Technology Data Exchange (ETDEWEB)

    Gil Agudo, A.; Torres Donaire, J.; Jimenez, J. C.; Carrascosa Fernandez, C.; Arjona Gutierrez, J.

    2011-07-01

    One of the tool increasingly deployed for the optimization of the procedures is the process management system according to a Quality Management. Likewise, for specific areas, such as central services within large institutions such as the General Hospitals of the systems of quality management is the most widely used ISO 9001. We describe in this paper our experience in implementing the system ISO 9001 in our Department of Radio physics and Radiation Protection (SRFPR).

  15. Exploring the Impact of ISO 9001, ISO 14001 and OHSAS 18001 Certification on Financial Performance: The Case of Companies listed on the Bucharest Stock Exchange

    Directory of Open Access Journals (Sweden)

    Mihaela Ionașcu

    2017-02-01

    Full Text Available The purpose of this paper is to investigate the impact of ISO 9001, ISO 14001 and OHSAS 18001 certification on the financial performance of Romanian companies listed on the Bucharest Stock Exchange (BSE. Based on audited financial statements of a population of 67 non-financial companies listed during 2013-2015 and using regression models, this paper shows, for the first time in Romania, that companies listed on BSE, implementing complex management systems (quality – environmental and/or occupational health and safety perform better, and that their performance is directly linked to the complexity of the management systems implemented.

  16. The costs and benefits of getting the ISO 9000 certification in the manufacturing sector in Saudi Arabia.

    Science.gov (United States)

    Mezher, T; Ramadan, H

    1998-01-01

    Many Saudi companies, in their journey to improve quality, efficiency and competitiveness, are pursuing and obtaining the ISO 9000 certificate. Many studies have evaluated how to implement ISO 9000 in different sectors, but none have analyzed the effectiveness of ISO 9000 certification (costs and benefits) on improving the overall quality and on meeting expectations. This study addressed these issues by investigating manufacturing organizations in Saudi Arabia that have the ISO 9000 certification. A survey questionnaire was distributed to firms throughout the kingdom. Thirty-two firms participated in the study. Results indicate that increased consistency of operations, improved service, and product quality are among the top motivators for pursuing the ISO certificate. The benefits most often experienced were improved awareness of procedural problems, better management control, keeping existing customers, increased customer satisfaction, and improved customer service. Difficulties experienced during the certification process involved time and cost, but these were not considered to be major problems. A high volume of paperwork was the main problem experienced following initial certification. Respondents in general said that the ISO 9000 certification met their expectations and that their level of satisfaction regarding the impact of ISO 9000 was high. Most recommended that other organizations pursue the certificate.

  17. ISO 9000 and the total quality management models

    OpenAIRE

    Pacios Lozano, Ana Reyes

    1997-01-01

    Establishes the most outstanding differences between the ISO 9000 norms and total quality management as forms or manners of managing quality used in some information services. Compares two models of total quality: European Foundation far Quality Management and Malcolm Baldrige Awards.

  18. Systems Engineering and Management Applications of ISO 9001:2015 for Government

    Science.gov (United States)

    Shepherd, Christena C.

    2016-01-01

    The manufacturing segment of the business world is busy assessing the impact of ISO 9001:2015, and updating their management systems to meet the required compliance date. What does the new revision mean for government agencies that deliver large engineering projects rather than mass production? In fact, the standard, especially the new revision, can be used quite readily for government agencies, or applied to specific projects, once it is understood in terms of the similarities with systems engineering and project management. From there it can be extrapolated to "mission realization" systems, and a Quality Management System (QMS) is a logical result that can bring order to processes and systems that likely already exist in some fashion. ISO 9001:2015 is less product-oriented than previous versions. It can be more broadly applied to public organizations as well as private; and to services (missions) as well as products. The emphasis on risk management in the revised standard provides the needed balance for weighing decisions with respect to cost, schedule, technical, safety, and regulatory compliance; so if this is not part of agency governance already, this is a good place to start, especially for large engineering projects. The Systems Engineering standard used for this analysis is from NASA's NPR 7123.1 NASA Systems Engineering Processes and Requirements; however, those who are more familiar with ISO/IEC 26702 Systems Engineering-application and management of the systems engineering process, or SAE/EIA 632 Processes for Engineering a System will also recognize the similarities. In reality, the QMS outlined by ISO 9001 reinforces the systems engineering processes, and serves to ensure that they are adequately implemented, although most of the ISO 9001 literature emphasizes the production and process aspects of the standard. Rather than beginning with ISO 9001and getting lost in the vocabulary, it is useful to begin with the systems engineering lifecycle

  19. The impact of ISO/TS 16949 on automotive industries and created organizational capabilities from its implementation

    Directory of Open Access Journals (Sweden)

    Bakhtiar Ostadi

    2010-12-01

    Full Text Available ISO/TS 16949 is an ISO Technical Specification. ISO/TS 16949 achieves the objectives which are continually to improve the production of automobile parts and related services, and to strengthen the international competition for the automotive industry and its suppliers. By applying this quality system standard, automotive manufacturers could offer superior products and good services to customers. The more the companies know about the benefits if quality management systems such as ISO/TS 16949, better they can seek interest and determine indices of these systems. So, this standard has been implemented in companies considering a number of benefits. In this paper, we carry out an empirical study in order to verify the importance these benefits and ranking them based on the value of importance. Finally, the study tends to provide a reference guide considering benefits assessment and created organizational capabilities from this standard for the automotive industry in pursuing ISO/TS 16949 and procuring maximum benefit from the results.

  20. A comprehensive iso-octane combustion model with improved thermochemistry and chemical kinetics

    KAUST Repository

    Atef, Nour

    2017-02-05

    Iso-Octane (2,2,4-trimethylpentane) is a primary reference fuel and an important component of gasoline fuels. Moreover, it is a key component used in surrogates to study the ignition and burning characteristics of gasoline fuels. This paper presents an updated chemical kinetic model for iso-octane combustion. Specifically, the thermodynamic data and reaction kinetics of iso-octane have been re-assessed based on new thermodynamic group values and recently evaluated rate coefficients from the literature. The adopted rate coefficients were either experimentally measured or determined by analogy to theoretically calculated values. Furthermore, new alternative isomerization pathways for peroxy-alkyl hydroperoxide (ȮOQOOH) radicals were added to the reaction mechanism. The updated kinetic model was compared against new ignition delay data measured in rapid compression machines (RCM) and a high-pressure shock tube. These experiments were conducted at pressures of 20 and 40 atm, at equivalence ratios of 0.4 and 1.0, and at temperatures in the range of 632–1060 K. The updated model was further compared against shock tube ignition delay times, jet-stirred reactor oxidation speciation data, premixed laminar flame speeds, counterflow diffusion flame ignition, and shock tube pyrolysis speciation data available in the literature. Finally, the updated model was used to investigate the importance of alternative isomerization pathways in the low temperature oxidation of highly branched alkanes. When compared to available models in the literature, the present model represents the current state-of-the-art in fundamental thermochemistry and reaction kinetics of iso-octane; and thus provides the best prediction of wide ranging experimental data and fundamental insights into iso-octane combustion chemistry.

  1. Neuroprotective effects of α-iso-cubebene against glutamate-induced damage in the HT22 hippocampal neuronal cell line.

    Science.gov (United States)

    Park, Sun Young; Jung, Won Jung; Kang, Jum Soon; Kim, Cheol-Min; Park, Geuntae; Choi, Young-Whan

    2015-02-01

    Since oxidative stress is critically involved in excitotoxic damage, we sought to determine whether the activation of the transcription factors, cAMP-responsive element binding protein (CREB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), by α-iso-cubebene is involved in its protective effects against glutamate-induced neuronal cell death. Pre-treatment with α-iso-cubebene significantly attenuated glutamate-induced cytotoxicity in mouse hippocampus-derived neuronal cells. α-iso-cubebene also reduced the glutamate-induced generation of reactive oxygen species and calcium influx, thus preventing apoptotic cell death. α-iso-cubebene inhibited glutamate-induced mitochondrial membrane depolarization and, consequently, inhibited the release of the apoptosis-inducing factor from the mitochondria. Immunoblot anlaysis revealed that the phosphorylation of extracellular signal-regulated kinase (ERK) by glutamate was reduced in the presence of α-iso-cubebene. α-iso-cubebene activated protein kinase A (PKA), CREB and Nrf2, which mediate the expression of the antioxidant enzymes, heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase [quinone] 1 (NQO1), involved in neuroprotection. In addition, α-iso-cubebene induced the expression of antioxidant responsive element and CRE transcriptional activity, thus conferring neuroprotection against glutamate-induced oxidative injury. α-iso-cubebene also induced the expression of Nrf2-dependent genes encoding HO-1 and NQO1. Furthermore, the knockdown of CREB and Nrf2 by small interfering RNA attenuated the neuroprotective effects of α-iso-cubebene. Taken together, our results indicate that α-iso-cubebene protects HT22 cells from glutamate-induced oxidative damage through the activation of Nrf2/HO-1/NQO-1, as well as through the PKA and CREB signaling pathways.

  2. ENVIRONMENTAL RESPONSIBILITY MODEL BASED ON ISO 14000 MANAGEMENT SYSTEMS

    Directory of Open Access Journals (Sweden)

    Catalina SITNIKOV

    2012-01-01

    Full Text Available Worldwide corporations, as well as their stakeholders, are more conscious of the need for environmental management, SR behaviour, and sustainable growth and development. International Standards are becoming more significant for corporations to work towards common environmental management practices. ISO 14001 is the first and the broadest standard intended at a more responsible approach of corporations and the world’s most acknowledged framework for environmental management systems that assists corporations to better manage the effect of their activities on the environment. This article aims to study ISO 14001 implementation and its effects on the environmental responsibility. A model will be built, which covers the environmental management system, the components of organizational culture, being able to influence environmental standards implementation.

  3. Motivational factors for the adoption of ISO 9001 standards in Eastern Europe: the case of Bulgaria

    Directory of Open Access Journals (Sweden)

    Svetoslav Georgiev

    2015-05-01

    Full Text Available Purpose: This study analyzes the motivational factors for ISO 9001 certification in Bulgaria from the internal/external motivations perspective, or the so-called dual model.Design/methodology/approach: This study is based on a mixed method research approach, which employed two interviews with experts in the field of quality management at the exploratory stage, and a survey involving 127 companies at the descriptive stage.Findings: This study claims that enhanced company image and competitiveness – an external motivation - is the leading motivational factor for ISO 9001 certification in Bulgaria. At the same time, our primary investigation reveals that Bulgarian firms are not predominantly externally driven, for internal motivations including process improvement and product quality improvement seem to be an important driver for ISO 9001 certification. Last but not least, this research asserts that enhanced company image and competitiveness has a stronger impact on the motivations for ISO 9001 certification than customer and supplier pressure, which is in line with previous research works on developing economy economies such as Bulgaria. Finally, our study indicates a moderate, yet positive correlation between motivations for and benefits of ISO 9001 certification.Social implications: This research work casts some light on the evolution of quality management in Bulgaria since the end of communism, which can serve as an important foundation for the better understanding of quality management in former communist economies in general and Eastern European states in particular.Originality/value: Derived from the acute gap between ISO studies in Western and former communist economies, this research work presents one of the first official, international studies in the field of ISO certification in Bulgaria, and more precisely, a paper describing the motives for ISO 9001 certification among Bulgarian businesses.

  4. Diseño e implantación de un sistema de gestión de la calidad y el medio ambiente certificables según ISO 9001:2000 e ISO 14001:2004

    OpenAIRE

    Boullón Cortés, Francisco Manuel

    2006-01-01

    El siguiente proyecto consiste en el diseño de un sistema integrado de gestión de calidad y medioambiente certificable por las normas ISO 9001 e ISO 14001. Dicho sistema está diseñado para una lavandería/tintorería industrial situada en la provincia de Cádiz llamada lavandería HISPANIA.

  5. A fully customizable MATLAB Framework for MSA based on ISO 5725 Standard

    International Nuclear Information System (INIS)

    D’Aucelli, Giuseppe Maria; Giaquinto, Nicola; Mannatrizio, Sabino; Savino, Mario

    2017-01-01

    In this paper, a full featured MATLAB framework for Measurement System Analysis, fully compliant with the ISO 5725 Repeatability and Reproducibility (R and R) assessment is presented. While preserving the operations prescribed in the ISO standard, the software presents distinct improvements. First of all, all computations are made using exact closed-form formulae (instead of statistical tables) allowing a consistent analysis without limitations on the number of participating laboratories and measurements, and using custom significance levels of statistical tests. Second, a double threshold decision system for each test step has been implemented, helping the statistician to decide on the elimination of outliers/stragglers. Third, ANOVA analysis has been included. The software therefore, besides producing quickly and efficiently all the graphical and numerical results required in an inter-laboratory experiment, provide guidelines for properly updating the ISO 5725 standard. (paper)

  6. Enhanced definition and required examples of common datum imposed by ISO standard

    Science.gov (United States)

    Yan, Yiqing; Bohn, Martin

    2017-12-01

    According to the ISO Geometrical Product Specifications (GPS), the establishment and definition of common datum for geometrical components are not fully defined. There are two main limitations of this standard. Firstly: the explications of ISO examples of common datums are not matched with their corresponding definitions, and secondly: a full definition of common datum is missing. This paper suggests a new approach for an enhanced definition and concrete examples of common datum and proposes a holistic methodology for establishment of common datum for each geometrical component. This research is based on the analysis of physical behaviour of geometrical components, orientation constraints and invariance classes of datums. This approach fills the definition gaps of common datum based on ISO GPS, thereby eliminating those deficits. As a result, an improved methodology for a fully functional defined definition of common datum was formulated.

  7. Stability of Kinesthetic Perception in Efferent-Afferent Spaces: The Concept of Iso-perceptual Manifold.

    Science.gov (United States)

    Latash, Mark L

    2018-02-21

    The main goal of this paper is to introduce the concept of iso-perceptual manifold for perception of body configuration and related variables (kinesthetic perception) and to discuss its relation to the equilibrium-point hypothesis and the concepts of reference coordinate and uncontrolled manifold. Hierarchical control of action is postulated with abundant transformations between sets of spatial reference coordinates for salient effectors at different levels. Iso-perceptual manifold is defined in the combined space of afferent and efferent variables as the subspace corresponding to a stable percept. Examples of motion along an iso-perceptual manifold (perceptually equivalent motion) are considered during various natural actions. Some combinations of afferent and efferent signals, in particular those implying a violation of body's integrity, give rise to variable percepts by artificial projection onto iso-perceptual manifolds. This framework is used to interpret unusual features of vibration-induced kinesthetic illusions and to predict new illusions not yet reported in the literature. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  8. Behavior of the aggregate wind resource in the ISO regions in the United States

    KAUST Repository

    Gunturu, Udaya

    2015-04-01

    The collective behavior of wind farms in seven Independent System Operator (ISO) areas has been studied. The generation duration curves for each ISO show that there is no aggregated power for some fraction of time. Aggregation of wind turbines mitigates intermittency to some extent, but in each ISO there is considerable fraction of time when there is less than 5% capacity. The hourly wind power time series show benefit of aggregation but the high and low wind events are lumped in time, thus indicating that intermittency is synchronized in each region. The timeseries show that there are instances when there is no wind power in most ISOs because of large-scale high pressure systems. An analytical consideration of the collective behavior of aggregated wind turbines shows that the benefit of aggregation saturates beyond a certain number of generating units asymptotically. Also, the benefit of aggregation falls rapidly with temporal correlation between the generating units.

  9. Behavior of the aggregate wind resource in the ISO regions in the United States

    KAUST Repository

    Gunturu, Udaya; Schlosser, Clemens Adam

    2015-01-01

    The collective behavior of wind farms in seven Independent System Operator (ISO) areas has been studied. The generation duration curves for each ISO show that there is no aggregated power for some fraction of time. Aggregation of wind turbines mitigates intermittency to some extent, but in each ISO there is considerable fraction of time when there is less than 5% capacity. The hourly wind power time series show benefit of aggregation but the high and low wind events are lumped in time, thus indicating that intermittency is synchronized in each region. The timeseries show that there are instances when there is no wind power in most ISOs because of large-scale high pressure systems. An analytical consideration of the collective behavior of aggregated wind turbines shows that the benefit of aggregation saturates beyond a certain number of generating units asymptotically. Also, the benefit of aggregation falls rapidly with temporal correlation between the generating units.

  10. DuPont IsoTherming clean fuel technology

    Energy Technology Data Exchange (ETDEWEB)

    Levinski, E. [E.I. DuPont Co., Wilmington, DE (United States)

    2009-07-01

    This poster described a hydroprocessing technology that DuPont has acquired from Process Dynamics, Inc. The IsoTherming clean fuel technology significantly reduces sulphur in motor fuels. The technology provides petroleum refiners the solution for meeting ultra low sulphur diesel requirements, at much lower costs than conventional technologies. IsoTherming hydroprocessing operates in a kinetically limited mode, with no mass transfer limitation. Hydrogen is delivered to the reactor in the liquid phase as soluble hydrogen, allowing for much higher space velocities than conventional hydrotreating reactors. Treated diesel is recycled back to the inlet of the reactor, generating less heat and more hydrogen into the reactor. The process results in a more isothermal reactor operation that allows for better yields, fewer light ends and greater catalyst life. The technology reduces coking, because the process provides enough hydrogen in the solution when cracking reactions take place. As a result, the process yields longer catalyst life. Other advantages for refiners include lower total investment; reduced equipment delivery lead times; reduced maintenance and operating costs; and configuration flexibility. tabs., figs.

  11. An Introduction to Information Security and ISO 27001

    CERN Document Server

    Watkins, Steve G

    2008-01-01

    This new pocket guide will suit both individuals who need an introduction to a topic that they know little about, and also organizations implementing, or considering implementing, some sort of information security management regime, particularly if using ISO/IEC 27001:2005

  12. Transcriptional and post-transcriptional upregulation of p27 mediates growth inhibition of isorhapontigenin (ISO) on human bladder cancer cells.

    Science.gov (United States)

    Jiang, Guosong; Huang, Chao; Li, Jingxia; Huang, Haishan; Wang, Jingjing; Li, Yawei; Xie, Fei; Jin, Honglei; Zhu, Junlan; Huang, Chuanshu

    2018-03-08

    There are few approved drugs available for the treatment of muscle-invasive bladder cancer (MIBC). Recently, we have demonstrated that isorhapontigenin (ISO), a new derivative isolated from the Chinese herb Gnetum cleistostachyum, effectively induces cell-cycle arrest at the G0/G1 phase and inhibits anchorage-independent cell growth through the miR-137/Sp1/cyclin D1 axis in human MIBC cells. Herein, we found that treatment of bladder cancer (BC) cells with ISO resulted in a significant upregulation of p27, which was also observed in ISO-treated mouse BCs that were induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Importantly, knockdown of p27 caused a decline in the ISO-induced G0-G1 growth arrest and reversed ISO suppression of anchorage-independent growth in BC cells. Mechanistic studies revealed that ISO promoted p27 expression at mRNA transcription level through increasing direct binding of forkhead box class O1 (FOXO1) to its promoter, while knockdown of FOXO1 attenuated ISO inhibition of BC cell growth. On the other hand, ISO upregulated the 3'-untranslated region (3'-UTR) activity of p27, which was accompanied by a reduction of miR-182 expression. In line with these observations, ectopic expression of miR-182 significantly blocked p27 3'-UTR activity, whereas mutation of the miR-182-binding site at p27 mRNA 3'-UTR effectively reversed this inhibition. Accordingly, ectopic expression of miR-182 also attenuated ISO upregulation of p27 expression and impaired ISO inhibition of BC cell growth. Our results not only provide novel insight into understanding of the underlying mechanism related to regulation of MIBC cell growth but also identify new roles and mechanisms underlying ISO inhibition of BC cell growth.

  13. Image-based Exploration of Iso-surfaces for Large Multi- Variable Datasets using Parameter Space.

    KAUST Repository

    Binyahib, Roba S.

    2013-05-13

    With an increase in processing power, more complex simulations have resulted in larger data size, with higher resolution and more variables. Many techniques have been developed to help the user to visualize and analyze data from such simulations. However, dealing with a large amount of multivariate data is challenging, time- consuming and often requires high-end clusters. Consequently, novel visualization techniques are needed to explore such data. Many users would like to visually explore their data and change certain visual aspects without the need to use special clusters or having to load a large amount of data. This is the idea behind explorable images (EI). Explorable images are a novel approach that provides limited interactive visualization without the need to re-render from the original data [40]. In this work, the concept of EI has been used to create a workflow that deals with explorable iso-surfaces for scalar fields in a multivariate, time-varying dataset. As a pre-processing step, a set of iso-values for each scalar field is inferred and extracted from a user-assisted sampling technique in time-parameter space. These iso-values are then used to generate iso- surfaces that are then pre-rendered (from a fixed viewpoint) along with additional buffers (i.e. normals, depth, values of other fields, etc.) to provide a compressed representation of iso-surfaces in the dataset. We present a tool that at run-time allows the user to interactively browse and calculate a combination of iso-surfaces superimposed on each other. The result is the same as calculating multiple iso- surfaces from the original data but without the memory and processing overhead. Our tool also allows the user to change the (scalar) values superimposed on each of the surfaces, modify their color map, and interactively re-light the surfaces. We demonstrate the effectiveness of our approach over a multi-terabyte combustion dataset. We also illustrate the efficiency and accuracy of our

  14. Análise da relação entre normas de sistema de gestão (ISO 9001, ISO 14001, NBR 16001 e OHSAS 18001 e a sustentabilidade empresarial

    Directory of Open Access Journals (Sweden)

    Camila dos Santos Ferreira

    Full Text Available Resumo A sustentabilidade pode ser inserida no contexto empresarial como uma forma de minimizar impactos causados pelos processos produtivos. Organizações utilizam as normas dos sistemas de gestão para satisfazer os anseios das partes interessadas. Sendo assim, o objetivo do estudo foi analisar a relação entre normas de sistemas de gestão (ISO 14001, ISO 9001, OHSAS 18001 e NBR 16001 e a sustentabilidade empresarial. O objetivo foi alcançado seguindo as seguintes etapas: Primeiramente, os requisitos da sustentabilidade empresarial foram identificados, baseados em Índice de Sustentabilidade Empresarial, Indicadores Ethos e Global Reporting Initiative. Posteriormente, a matriz que relaciona os requisitos da sustentabilidade e os das normas foi construída. A matriz foi preenchida pela pesquisadora e por mais seis especialistas. As respostas foram consolidadas, gerando-se a Matriz de Relação Consolidada, a qual foi analisada e interpretada. As relações foram classificadas como forte, moderada, fraca ou nula. Os resultados da pesquisa apontam que ISO 9001 e OHSAS 18001 possuem relação fraca com a sustentabilidade empresarial. A ISO 14001 apresenta relação moderada e a NBR 16001, relação forte. A pesquisa concluiu que os padrões normativos podem auxiliar as empresas a introduzirem a sustentabilidade em seu contexto, no entanto, ISO 9001 e OHSAS 18001 são normas que abordam apenas alguns elementos da sustentabilidade empresarial. A NBR 16001 é a norma que mais apresenta elementos da sustentabilidade em seu escopo. Sendo assim, empresas que objetivam introduzir a sustentabilidade no ambiente corporativo poderiam focar na implementação da NBR 16001.

  15. Composite repairs qualification according to ISO/TS 24817

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A. [Petroleo Brasileiro S.A. (PETROBRAS/CENPES), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

    2009-07-01

    Composite repairs for metallic pipes from three different suppliers were evaluated according to ISO Technical Specification TS 24817. The intended application scenarios are offshore production plants, but the design methodology is also applicable to onshore pipelines and pipework. The evaluation covered all the relevant mechanical properties and established the maximum application temperatures for each repair system. The tests also considered the application of composite repair sleeves to metallic pipes with through thickness defects, by measuring the strain energy release rates of the composite-metal interfaces. The test campaigns aimed to verify the applicability of the recently published ISO document, and to implement it as the routine procedure for composite repairs evaluation within PETROBRAS. The tests also addressed the influence of metallic pipe surface preparation on the final properties of the repair sleeves, especially in relation to the long term behavior of leaking pipes repaired by means of composite materials. (author)

  16. Deductions about survival-curve parameters from iso-effect radiation regimes

    International Nuclear Information System (INIS)

    Mole, R.H.

    1975-01-01

    Criteria which permit iso-effect radiation regimes to be regarded as equivalent in terms of cell depletion are briefly discussed. Observations on whole-body irradiation of mice by split and multiple exposures suggest that Dsub(Q) for haematopoietic stem cells in the non-cycling state is approximately 100 rad but about zero when they are cycling. Corresponding changes in radiobiological properties of cells are to be expected during the course of fractionated and protracted exposures in vivo when the iso-effect of interest is relatively gross tissue damage. Responses to ionizing radiation in vivo are dependent on aspects of cellular organisation which are missing from in vitro experimentation. (author)

  17. Impacts of the ISO 14000 management system on sustainable forest management in South Africa

    CSIR Research Space (South Africa)

    Von Maltitz, Graham P

    2000-01-01

    Full Text Available are all issues that will lead to a unique ISO implementation within the country. ISO 14000 is not a product certification. As such it does not help companies market their products where ‘green labelling’ is becoming the norm. It is probably for this reason...

  18. International standard (ISO) of radiation sterilization and issues in the sterilization dose setting

    International Nuclear Information System (INIS)

    Takehisa, Masaaki

    1995-01-01

    The ISO dose setting method 1 uses bioburden and verification by sublethal sterility test. Current devices produced in clean environmental have low bioburden, however, sensitivity of verification test declines at low bioburden. Validation of verification in this region should be further studied. A dose setting using D 10 of bioburden isolates should be reevaluated and included in the ISO. (author)

  19. Akreditacija medicinskog laboratorija prema ISO 15189:2003. Meksičko iskustvo

    OpenAIRE

    Sierra-Amor, Rosa I.; Lopez-Martinez, Maribel

    2007-01-01

    Međunarodna norma ISO15189:2003 iziskuje od laboratorija da udovolje zahtjevima za upravljanje kvalitetom kao i tehničkim uvjetima, uključujući prije- i poslije-analitičke faze te sam analitički proces. Norma obuhvaća i teme kao što su sigurnost i etika u medicinskom laboratoriju. S obzirom da se primjenjuju lokalni, nacionalni i regionalni propisi, ISO 15189:2003 traži da medicinski laboratoriji dokažu svoju kompetentnost neovisnom procjenitelju, a to je obično nacionalno akreditacijsko t...

  20. Management system - PNS ISO/IEC 17025:2005

    International Nuclear Information System (INIS)

    Baje, Perla F.

    2009-01-01

    Management system is a set of policies, processes and procedures needed for planning and execution in the core business area of the organization. It is a set of policies and objectives to direct and control an organization with regard to quality. ISO 17025:2005 is the administrative and technical systems that govern the operations of the laboratory

  1. The Effect of ISO 9001 and the EFQM Model on Improving Hospital Performance: A Systematic Review.

    Science.gov (United States)

    Yousefinezhadi, Taraneh; Mohamadi, Efat; Safari Palangi, Hossein; Akbari Sari, Ali

    2015-12-01

    This study aimed to explore the effect of the International Organization for Standardization (ISO) ISO 9001 standard and the European foundation for quality management (EFQM) model on improving hospital performance. PubMed, Embase and the Cochrane Library databases were searched. In addition, Elsevier and Springer were searched as main publishers in the field of health sciences. We included empirical studies with any design that had used ISO 9001 or the EFQM model to improve the quality of healthcare. Data were collected and tabulated into a data extraction sheet that was specifically designed for this study. The collected data included authors' names, country, year of publication, intervention, improvement aims, setting, length of program, study design, and outcomes. Seven out of the 121 studies that were retrieved met the inclusion criteria. Three studies assessed the EFQM model and four studies assessed the ISO 9001 standard. Use of the EFQM model increased the degree of patient satisfaction and the number of hospital admissions and reduced the average length of stay, the delay on the surgical waiting list, and the number of emergency re-admissions. ISO 9001 also increased the degree of patient satisfaction and patient safety, increased cost-effectiveness, improved the hospital admissions process, and reduced the percentage of unscheduled returns to the hospital. Generally, there is a lack of robust and high quality empirical evidence regarding the effects of ISO 9001 and the EFQM model on the quality care provided by and the performance of hospitals. However, the limited evidence shows that ISO 9001 and the EFQM model might improve hospital performance.

  2. Relationship of responsible Care and Environmental Management Systems Standard ISO 14001. Example of Sumitomo Chemical; Resuponshiburu{center_dot}kea to kankyo manejimento sisutemu kikaku ISO14001. Sumitomo kagaku no jirei

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Kazuo. [Sumitomo Chemical Corp., Tokyo (Japan)

    1999-01-15

    In the chemical sector, Responsible Care is propelled by the International Council of Chemical Associations (ICCA). The objective of Responsible Care is to improve the performance and reputation of the Chemical Industry in areas that impact on people and environment. Sumitomo Chemical is committed to supporting a continuing effort to improve the chemical industry`s responsible management of chemicals through the Japan Responsible Vare Vouncil program. One the other hand, ISO 14001 had been published on Aug.1996 and have adopted the ISO 14001 as national standards on Oct. 1996. Already 973 companies in Japan, 74 of them in the chemical sector, have been certified to ISO 14001. In this paper, I provides concise commentaries on how Responsible Care and Environmental management systems work in the chemical sector. (author)

  3. Relationship of responsible Care and Environmental Management Systems Standard ISO 14001. Example of Sumitomo Chemical. Resuponshiburu[center dot]kea to kankyo manejimento sisutemu kikaku ISO14001. Sumitomo kagaku no jirei

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Kazuo. (Sumitomo Chemical Corp., Tokyo (Japan))

    1999-01-15

    In the chemical sector, Responsible Care is propelled by the International Council of Chemical Associations (ICCA). The objective of Responsible Care is to improve the performance and reputation of the Chemical Industry in areas that impact on people and environment. Sumitomo Chemical is committed to supporting a continuing effort to improve the chemical industry's responsible management of chemicals through the Japan Responsible Vare Vouncil program. One the other hand, ISO 14001 had been published on Aug.1996 and have adopted the ISO 14001 as national standards on Oct. 1996. Already 973 companies in Japan, 74 of them in the chemical sector, have been certified to ISO 14001. In this paper, I provides concise commentaries on how Responsible Care and Environmental management systems work in the chemical sector. (author)

  4. ISO 9001 aspects related to performance and their level of implementation

    Directory of Open Access Journals (Sweden)

    Jordi Castello Dalmau

    2016-12-01

    Full Text Available Purpose: In the last three decades, thousands of companies around the world have embraced the ISO 9001 standard in their quest to improve company performance and customer satisfaction. In recent literature, a number of authors have identified different “levels” of ISO 9001 implementation. This study aims to analyse these implementation levels in companies from the point of view of the customer, and provide guidelines for future improvement. Design/methodology/approach: Research was conducted based on the results of the second-party audits (SPAs of 90 suppliers, (including component suppliers, assemblers, and wind farm operation and maintenance services, to one of the wind power industry’s largest wind turbine manufacturers. The audits were carried out within the ISO 9001:2008 framework and conducted by one of this study’s authors in his role as the wind turbine company’s Director of Global Quality. Findings: Auditing suppliers plays a unique role in helping to isolate system weaknesses, identify opportunities and suggest areas for improvement. This study shows that, in terms of management commitment and culture and the good practices of an organization, ISO 9001 certified companies implement differing degrees of the standard. From the results of this research, a "road map" towards improvement can be established; one that allows companies in the sector to go beyond simply being accredited with the standard and instead to take advantage of ISO 9001 certification as a catalyst for change. Research limitations/implications: This article focuses only on the wind power sector, although its findings could be extrapolated to similar sectors of high technology and high levels of customization. Originality/value: While quality audits are a customary topic for academics and researchers, few contributions are related to SPAs and their impact on the quality control process of company suppliers. Primary data from the SPAs of suppliers (objective

  5. ISO 9001 aspects related to performance and their level of implementation

    Energy Technology Data Exchange (ETDEWEB)

    Castello Dalmau, J.; Gimenez, G.; Castro, R. de

    2016-07-01

    Purpose: In the last three decades, thousands of companies around the world have embraced the ISO 9001 standard in their quest to improve company performance and customer satisfaction. In recent literature, a number of authors have identified different “levels” of ISO 9001 implementation. This study aims to analyse these implementation levels in companies from the point of view of the customer, and provide guidelines for future improvement. Design/methodology/approach: Research was conducted based on the results of the second-party audits (SPAs) of 90 suppliers, (including component suppliers, assemblers, and wind farm operation and maintenance services), to one of the wind power industry’s largest wind turbine manufacturers. The audits were carried out within the ISO 9001:2008 framework and conducted by one of this study’s authors in his role as the wind turbine company’s Director of Global Quality. Findings: Auditing suppliers plays a unique role in helping to isolate system weaknesses, identify opportunities and suggest areas for improvement. This study shows that, in terms of management commitment and culture and the good practices of an organization, ISO 9001 certified companies implement differing degrees of the standard. From the results of this research, a road map towards improvement can be established; one that allows companies in the sector to go beyond simply being accredited with the standard and instead to take advantage of ISO 9001 certification as a catalyst for change. Research limitations/implications: This article focuses only on the wind power sector, although its findings could be extrapolated to similar sectors of high technology and high levels of customization. Originality/value: While quality audits are a customary topic for academics and researchers, few contributions are related to SPAs and their impact on the quality control process of company suppliers. Primary data from the SPAs of suppliers (objective data collected by one

  6. ISO 9001 aspects related to performance and their level of implementation

    International Nuclear Information System (INIS)

    Castello Dalmau, J.; Gimenez, G.; Castro, R. de

    2016-01-01

    Purpose: In the last three decades, thousands of companies around the world have embraced the ISO 9001 standard in their quest to improve company performance and customer satisfaction. In recent literature, a number of authors have identified different “levels” of ISO 9001 implementation. This study aims to analyse these implementation levels in companies from the point of view of the customer, and provide guidelines for future improvement. Design/methodology/approach: Research was conducted based on the results of the second-party audits (SPAs) of 90 suppliers, (including component suppliers, assemblers, and wind farm operation and maintenance services), to one of the wind power industry’s largest wind turbine manufacturers. The audits were carried out within the ISO 9001:2008 framework and conducted by one of this study’s authors in his role as the wind turbine company’s Director of Global Quality. Findings: Auditing suppliers plays a unique role in helping to isolate system weaknesses, identify opportunities and suggest areas for improvement. This study shows that, in terms of management commitment and culture and the good practices of an organization, ISO 9001 certified companies implement differing degrees of the standard. From the results of this research, a road map towards improvement can be established; one that allows companies in the sector to go beyond simply being accredited with the standard and instead to take advantage of ISO 9001 certification as a catalyst for change. Research limitations/implications: This article focuses only on the wind power sector, although its findings could be extrapolated to similar sectors of high technology and high levels of customization. Originality/value: While quality audits are a customary topic for academics and researchers, few contributions are related to SPAs and their impact on the quality control process of company suppliers. Primary data from the SPAs of suppliers (objective data collected by one

  7. The ISO 5-pass authentication in χ-Spaces

    DEFF Research Database (Denmark)

    Cáccamo, Mario J.; Crazzolara, Federico; Milicia, Giuseppe

    2002-01-01

    We implement the ISO 5-pass authentication protocol and study its correctness using the χ-Space framework. χ-Spaces is a novel domain specific programming language designed for developing protocols and in particular security protocols. χ-Spaces programming language is an implementation of SPL...

  8. EVALUASI EFEKTIVITAS PENERAPAN SISTEM MANAJEMEN LINGKUNGAN ISO 14001 DI PABRIK BAN XYZ-JAWA BARAT (Evaluation on The Effectiveness of Implementation ISO 14001 Environmental Management System in XYZ Tyre Factory-West Java

    Directory of Open Access Journals (Sweden)

    Muhammad Ryan Natasaputra

    2015-11-01

    Full Text Available ABSTRAK Pabrik ban XYZ yang berlokasi di Jawa Barat merupakan salah satu industri ban yang telah memiliki komitmen untuk meningkatkan kinerja lingkungan dengan menerapkan Sistem Manajemen Lingkungan (SML ISO 14001. Tujuan dari penelitian ini adalah untuk mengevaluasi efektivitas penerapan SML ISO 14001 berdasarkan kinerja manajemen, kinerja lingkungan, dan kesesuaian dengan sertifikasi Occupational Health and Safety Assessment Series (OHSAS 18001. Penelitian ini dilakukan dengan dua metode, yaitu pengumpulan data primer melalui pemantauan lapang dan data sekunder melalui dokumen-dokumen yang berhubungan dengan SML serta data hasil pengukuran Aspek Lingkungan Penting (ALP. Data tersebut dievaluasi dan dibandingkan dengan SNI 19-14001-2005, program lingkungan perusahaan, serta peraturan perundangan yang berlaku agar diketahui efektivitas penerapan SML ISO 14001. Hasil penelitian menunjukkan bahwa kebijakan lingkungan telah sesuai dengan tiga komitmen utama dalam SNI 19-14001-2005. Prosedur identifikasi dan klasifikasi ALP telah dilaksanakan dengan metode penilaian terhadap empat kriteria yang dibuat oleh pihak manajemen pabrik ban. Data hasil pengukuran ALP yang dievaluasi meliputi kebisingan, debu, limbah cair industri, dan penggunaan air. Efektivitas penerapan SML ISO 14001 di pabrik ban melalui hasil penilaian kinerja manajemen sebesar 80% dan kinerja lingkungan dari data hasil pengukuran ALP sebesar 81,3%, secara umum membuktikan bahwa penerapan SML ISO 14001 dengan nilai pencapaian sebesar 80,7% telah efektif dalam memenuhi tujuan dari komitmen pencegahan pencemaran, penerapan program lingkungan, dan peraturan perundangan yang berlaku. Ketidaksesuaian disebabkan oleh masalah komunikasi, kesadaran karyawan, dan kelayakan teknis. Dalam hal keselamatan dan kesehatan kerja terdapat integrasi dengan OHSAS 18001 melalui penggunaan Alat Pelindung Diri (APD dan prosedur tanggap darurat.   ABSTRACT XYZ tyre factory in West Java is one of the tyre

  9. Quality control in the waste water treatment: ISO 9000 in an EDAR; Control de calidad en la depuracion de aguas residuales: ISO 9000 en una EDAR

    Energy Technology Data Exchange (ETDEWEB)

    Marcote Lago, J. M.; Laino Lopez, H.; Moreira Vilar, M. T.; Feijoo Costal, G.

    2002-07-01

    The Quality has been converted into an indispensable tool into the managerial world, considering the high degree of competitiveness of products and associated processes, as well as the increase of the needs and requirements of the consumers. In this article the action are analyzed directed to obtain the quality degree, according to the norm ISO 9000, on the stations of waste water treatment (EDAR). for it, there are established the guidelines of planning of the maintenance in an EDAR, which will redound to an improvement of its management as step before the certification of the norm ISO 9000. (Author) 5 refs.

  10. IT内部統制に関する考察 : ISO27001 ISO9001の活用

    OpenAIRE

    赤林, 隆仁; Takahito, AKABAYASHI

    2007-01-01

    日本の上場企業はIT化が進展しており、内部統制においてもIT を前提としたものが要求される。そのための安価で適用し易いフレームワークとして多くの企業で経験のあるISO 27001(情報セキュリティシステム)、ISO 9001(品質システム)を活用できないかを検討した。その結果この2 つを併用するとIT を前提とする内部統制の要求事項を網羅できることが判明した。内部統制を意識して2 つの基準を適用すれば内部統制に係わる費用の削減につながることが推測された。...

  11. [Quality assurance in oncology: experiences of an ISO certification].

    Science.gov (United States)

    Szentirmay, Zoltán; Cseh, Lujza; Ottó, Szabolcs; Kásler, Miklós

    2002-01-01

    The ISO 9001 quality assurance of the National Institute of Oncology has been achieved successfully. We give an account of the brief history and the structure of the assurance system of the Institute, the process of setting our goals, and also the experience gained from drafting ISO 9001 handbook and flowcharts. Apart from the bureaucratic nature of quality assurance, it is a good opportunity for us to investigate our everyday work, put it into orderly manner and work more reliably. Experience has shown that the introduction of a quality assurance system increases the level of patient care, the documentation helps the Institute or some of its departments, or even individuals prevent law suits, and serves as a sound basis for proposing promotion, salary increases and bonuses, or even honors.

  12. ISO Science Legacy A Compact Review of ISO Major Achievements

    CERN Document Server

    Cesarsky, Catherine J

    2006-01-01

    Stars are born and die in clouds of gas and dust, opaque to most types of radiation, but transparent in the infrared. Requiring complex detectors, space missions and cooled telescopes, infrared astronomy is the last branch of this discipline to come of age. After a very successful sky survey performed in the eighties by the IRAS satellite, the Infrared Space Observatory, in the nineties, brought spectacular advances in the understanding of the processes giving rise to powerful infrared emission by a great variety of celestial sources. Outstanding results have been obtained on the bright comet Hale-Bopp, and in particular of its water spectrum, as well as on the formation, chemistry and dynamics of planetary objects in the solar system. Ideas on the early stages of stellar formation and on the stellar initial mass function have been clarified. ISO is the first facility in space able to provide a systematic diagnosis of the physical phenomena and the chemistry in the close environment of pre-main sequence stars...

  13. From waste minimization to ISO 14000: Taiwan`s experience and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Wen-Huei Chen; Wain-Sun Hou [China Technical Consultants, Inc., Taipei (Taiwan, Province of China)

    1996-12-31

    Taiwan has completed a very successful five-year industrial waste minimization (IWM) demonstration and promotion project sponsored by the government. From 1990 to 1995, the project successfully disseminated the IWM concept of pollution prevention (P2) to industries. It effectively reduced industrial waste while significantly benefitting the economy by assisting industries in implementing in-plant IWM programs. In July 1995, the second stage of the five-year IWM and ISO 14000 promotion project was initiated for further promoting the IWM, P2, and cleaner production and, in particular, coping with the upcoming international environmental management standards (ISO 14000). To assist industries in establishing an environmental management system (EMS) and accumulating related experience, an EMS pilot demonstration project of five model industries and an ISO 14001 EMS demonstration and promotion project for 22 factories in 13 industries were initiated in October 1995 and August 1996, respectively. These projects can assist Taiwan`s industries in changing the constitution of their enterprises, enhancing competition in the international market, and helping our nation achieve the forerunner`s profits in sustainable development. 9 refs., 3 figs.

  14. A comprehensive experimental and modeling study of iso-pentanol combustion

    KAUST Repository

    Sarathy, Mani

    2013-12-01

    Biofuels are considered as potentially attractive alternative fuels that can reduce greenhouse gas and pollutant emissions. iso-Pentanol is one of several next-generation biofuels that can be used as an alternative fuel in combustion engines. In the present study, new experimental data for iso-pentanol in shock tube, rapid compression machine, jet stirred reactor, and counterflow diffusion flame are presented. Shock tube ignition delay times were measured for iso-pentanol/air mixtures at three equivalence ratios, temperatures ranging from 819 to 1252. K, and at nominal pressures near 40 and 60. bar. Jet stirred reactor experiments are reported at 5. atm and five equivalence ratios. Rapid compression machine ignition delay data was obtained near 40. bar, for three equivalence ratios, and temperatures below 800. K. Laminar flame speed data and non-premixed extinction strain rates were obtained using the counterflow configuration. A detailed chemical kinetic model for iso-pentanol oxidation was developed including high- and low-temperature chemistry for a better understanding of the combustion characteristics of higher alcohols. First, bond dissociation energies were calculated using ab initio methods, and the proposed rate constants were based on a previously presented model for butanol isomers and n-pentanol. The model was validated against new and existing experimental data at pressures of 1-60. atm, temperatures of 650-1500. K, equivalence ratios of 0.25-4.0, and covering both premixed and non-premixed environments. The method of direct relation graph (DRG) with expert knowledge (DRGX) was employed to eliminate unimportant species and reactions in the detailed mechanism, and the resulting skeletal mechanism was used to predict non-premixed flames. In addition, reaction path and temperature A-factor sensitivity analyses were conducted for identifying key reactions at various combustion conditions. © 2013 The Combustion Institute.

  15. A comprehensive experimental and modeling study of iso-pentanol combustion

    KAUST Repository

    Sarathy, Mani; Park, Sungwoo; Weber, Bryan W.; Wang, Weijing; Veloo, Peter S.; Davis, Alexander C.; Togbé , Casimir; Westbrook, Charles K.; Park, Okjoo; Dayma, Guillaume; Luo, Zhaoyu; Oehlschlaeger, Matthew A.; Egolfopoulos, Fokion N.; Lu, Tianfeng; Pitz, William J.; Sung, Chihjen; Dagaut, P.

    2013-01-01

    Biofuels are considered as potentially attractive alternative fuels that can reduce greenhouse gas and pollutant emissions. iso-Pentanol is one of several next-generation biofuels that can be used as an alternative fuel in combustion engines. In the present study, new experimental data for iso-pentanol in shock tube, rapid compression machine, jet stirred reactor, and counterflow diffusion flame are presented. Shock tube ignition delay times were measured for iso-pentanol/air mixtures at three equivalence ratios, temperatures ranging from 819 to 1252. K, and at nominal pressures near 40 and 60. bar. Jet stirred reactor experiments are reported at 5. atm and five equivalence ratios. Rapid compression machine ignition delay data was obtained near 40. bar, for three equivalence ratios, and temperatures below 800. K. Laminar flame speed data and non-premixed extinction strain rates were obtained using the counterflow configuration. A detailed chemical kinetic model for iso-pentanol oxidation was developed including high- and low-temperature chemistry for a better understanding of the combustion characteristics of higher alcohols. First, bond dissociation energies were calculated using ab initio methods, and the proposed rate constants were based on a previously presented model for butanol isomers and n-pentanol. The model was validated against new and existing experimental data at pressures of 1-60. atm, temperatures of 650-1500. K, equivalence ratios of 0.25-4.0, and covering both premixed and non-premixed environments. The method of direct relation graph (DRG) with expert knowledge (DRGX) was employed to eliminate unimportant species and reactions in the detailed mechanism, and the resulting skeletal mechanism was used to predict non-premixed flames. In addition, reaction path and temperature A-factor sensitivity analyses were conducted for identifying key reactions at various combustion conditions. © 2013 The Combustion Institute.

  16. An Utilization Method Cooperating ISO drawings and Bookmarks for NDE

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Hyun-Ju; Cho, Chan-Hee; Lee, Tae-Hun [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    The inspection of weld parts are performed with various non-destructive test methods such as AUT, VT, PT, ECT, etc. The results have been published in the report booklets. Moreover, huge amount of non-destructive inspection data and reports, which are produced from the '78 Kori 1 to newly constructed power plant, are stored in the management department and DDCC of each power plant. Because the data are not classified, it takes much time to find the corresponding non-destructive test results report of a specific unit of a power plant for a particular year. In addition, it is possibility to make human error because the report is written and submitted after finding manually the non-destructive test results for the concerning weld. When there is a dispute of the results of non-destructive inspection of a particular weld, analyzes the control center, a result of the power plant and the corresponding non-destructive inspection of a particular weld of ISO drawing in many places such as control center, corresponding power plant and CRI was discussed together will be to derive the final conclusion. For discussion, the person in charge of each site, looking for ISO drawings there is a result of the weld, in the past results history report of non-destructive testing for this, by searching the results of the welding site, telephone and E-mail disadvantage of complicated procedures if necessary to the discussion together in -mail is performed I have. In this paper, we describe the contents introduced the ISO drawings and Bookmark function is trying to complement these drawbacks. By applying the present invention utilization, find the ISO drawings manually when querying the results of the non-destructive inspection of past weld, which reduces the time to grasp the content of the non-destructive test results report.

  17. Simple method for calculation of heat loss through floor/beam-wall intersections according to ISO 9164

    International Nuclear Information System (INIS)

    Dilmac, Sukran; Guner, Abdurrahman; Senkal, Filiz; Kartal, Semiha

    2007-01-01

    The international standards for calculation of energy consumption for heating are ISO 9164 and EN 832. Although they are based on similar principles, there are significant differences in the calculation procedure of transmission heat loss coefficient, H T , especially in the evaluation of thermal bridges. The calculation of H T and the way thermal bridges are to be taken into consideration are explained in detail in EN 832 and in a series of other linked standards. In ISO 9164, the parameters used in the relevant equations are cited, but there is a lack of explanation about how they will be determined or calculated. Although in ISO 6946-2, the earlier version of the same standard, the calculation methods of these quantities were explained for column-wall intersections; in the revised ISO 6946, these explanations have been removed. On the other hand, these parameters had never been defined for floor/beam-wall intersections. In this paper, a new method is proposed for calculation of the parameters cited in ISO 9164 for floor/beam-wall intersections. The results obtained by the proposed method for typical floor with beam sections are compared with the results obtained by the methods stated in EN 832/EN 13789/EN ISO 14683 and the results obtained from 2D analysis. Different methods are evaluated as to their simplicity and agreement

  18. Revision of ISO 15859 Aerospace Fluid Standards

    Science.gov (United States)

    Greene, Benjamin; McClure, Mark B.

    2012-01-01

    A detailed review of ISO 15859 "Space Systems - Fluid Characteristics, Sampling and Test Methods" was performed An approach to revising Parts 1-9 and 11-13 was developed and concurred by the NASA Technical Standards Program Office. The approach was to align them with the highest level source documents, and not to program-specific requirements. The updated documents were prepared and presented.

  19. ISO and EIGA standards for cryogenic vessels and accessories

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The EIGA/WG 6’s scope is cryogenic vessels and accessories, including their design, material compatibility, operational requirements and periodical inspection. The specific responsibilities include monitoring international standardization (ISO, CEN) and regulations (UN, TPED, PED...

  20. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice

    Science.gov (United States)

    Sadraei, H.; Ghanadian, M.; Asghari, G.; Azali, N.

    2014-01-01

    Isovanillin and iso-acetovanillon are two phenolic components isolated from a number of plants including Pycnocycla spinosa. P. spinosa extract has antispasmodic and antidiarrheal activities. However, no comparative study has been done on antidiarrheal action of isovanillin and iso- acetovanillon, so far. The aim of this study was to investigate antidiarrheal action of isovanillin and iso-acetovanillon and their effects on small intestinal transit, for comparison with propantheline. Male mice (25-30 g), fasted over night with free access to water, were treated with test compounds or control (p.o.). Thirty min later castor oil (0.5 ml) was given orally to the animals. In another groups of animals MgSO4 (0.5 ml of 10% solution) was given first and half an hour later the test drugs were administered. Onset and number of wet defecations were recorded for each animal over 3.5 h after treatment with diarrhoea inducing agents. In another groups, intestinal transit of charcoal meal was determined following administration of the compounds. Isovanillin (2 mg/kg & 5 mg/kg), iso-acetovanillon (2 mg/kg & 5 mg/kg) and P. spinosa extract (5 mg/kg) delayed onset of diarrhoea and significantly reduced wet defecation induced by castor oil and MgSO4. They all had antidiarrheal effect similar to propantheline (5 mg/kg). Isovanillin, iso-acetovanillon and P. spinosa extract compared to control groups, significantly reduced small intestinal transit of charcoal meal. This study shows that antidiarrheal effect of P. spinosa extract is at least partially due to presence of two active compounds isovanillin and iso-acetovanillon. PMID:25657776

  1. ISO, unique explorer of the invisible cool universe

    Science.gov (United States)

    1995-10-01

    As Roger Bonnet, director of ESA's science programme, explains: "The ISO launch will be the culmination of twelve years of intensive effort to build tile mast powerful and precise infrared space telescope to dote, We fully expect astronomers in Europe. and all over the wand, to be rewarded with unprecedented insights into the particularly rich and fertile sources of the universe hidden in the infrared." For the mission looks set to mark a new step forward for astronomy. To date, infrared astronomy has always been hampered by two major difficulties. The first is that infrared radiation is thermal, calorific. This means that any body which is not absolutely cold naturally emits this type of "heat" or "hidden" radiation, Consequently, at the corresponding wavelengths, all telescopes, detectors and the Earth's atmosphere appear to shine spontaneously, Infrared observation is therefore tantamount to attempting to observe the stars in broad daylight using a telescope a million times more luminous than the stars themselves. Moreover, the atmosphere is partly or totally opaque to infrared light. Hence the great attraction of conducting such observations from space, above the Earth's atmospheric layers. using a very low-temperature telescope. The first - and, so far, truly - Satellite actually to have done so is the Infrared Astronomical Satellite (IRAS) - a joint UK/Dutch/US mission - which surveyed and catalogued the sky far ten months in 1983. A corner of the curtain was thus lifted, The scene was set. Now, the task is to observe each character, each object. And here, infrared astronomy is hampered by a second major difficulty: the very detection of light. For while infrared radiation was discovered back in 1800 (in the solar spectrum). infrared-sensitive photoelectric detectors did not materialise until the Second World War, IRAS itself had to make do without the multi-dimensional set-ups that would have allowed it to record true images. It had to build up its images

  2. Which competitive advantages can firms really obtain from ISO14001 certification?

    Directory of Open Access Journals (Sweden)

    Josefina Lucia Murillo-Luna

    2008-12-01

    Full Text Available Ten years after the introduction of ISO14001, in this paper we present empirical evidence about the competitive advantages that managers associate to this environmental practice, from a sample of industrial firms located in Spain. The results indicate that the potential competitive advantages are: improvement of the internal efficiency, differentiation advantages, attention to the stakeholders’ requirements, enhancement of the competitive position in the sector and financial savings. Nevertheless managers’ expectations of improving internal efficiency might be the real reason that encourages firms to make the voluntary decision of investing in ISO14001 certification.

  3. The hidden networks of knowledge in ISO 14001

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik

    2003-01-01

    The ISO 14001 standard is defined as a management standard based on an assumed existing knowledge base of what is to be considered being environmental problems. In the implementation of the standard is become evident, that its use and impact is entirely dependent of the existence of networks...

  4. Avaliação de programas de qualidade mediante implantação da ISO 9000 Assessment of quality programns by the implantation of ISO 9000

    Directory of Open Access Journals (Sweden)

    Guilherme Guedes Xavier

    1995-08-01

    Full Text Available Interessado na disseminação de processos de implantação de Programas de Qualidade em empresas Brasileiras, o Grupo Nacional de Organização da Produção - GNOP realizou uma pesquisa sobre a avaliação desses programas, em empresas certificadas pela ISO 9000. Em uma primeira etapa, a pesquisa compreendeu o envio de um questionário aberto para empresas já certificadas, no Brasil, pela ISO 9000 (9001, ou 9002, ou 9003 e que tiveram a obtenção desse certificado divulgada por meio de publicações técnicas. A partir dos primeiros resultados, um segundo questionário, desta vez fechado, foi novamente enviado às empresas. Finalmente, as informações coletadas foram avaliadas por meio de visitas a doze empresas, escolhidas na região de atuação de cada uma das instituições que integram o GNOP. Neste trabalho são apresentados os principais resultados da pesquisa.The Grupo Nacional de Organização da Produção - GNOP - has completed research concerning the implementation of Quality Programs in Brazilian enterprizes, based on the ISO 9000 certification process. As a first step, questionnaires were sent to those companies already certified by the ISO 9000. Based on the first results, a second questionnaire was prepared and sent out again to those companies. Finally, the information gathered was evaluated and analysed by means of technical visits to twelve companies, regionally distributed among the groups that take part in the GNOP. This paper presents the main results.

  5. The relevance of the ISO26000 social responsibility issues to the Hong Kong construction industry

    Directory of Open Access Journals (Sweden)

    Lisa Robyn Barnes

    2013-09-01

    Full Text Available CorporateSocial Responsibility (CSR, the responsibility of a corporation for theimpacts of its decisions on society and the environment, originated as a termin the 1950’s (Carroll 1999. However, ISO 26000 (ISO 2010“Guidance on Social Responsibility” published in November 2010, redefines “SocialResponsibility” (“SR” broadly, by reference to SR principles, core subjectsand issues. The Hong Kong Construction Industry (“HKCI” sector is critical to Hong Kong’s economy, accounting for5.6% of the GDP and 9.2% of employment in 1999 (Tang 2001. In 2011, the gross value of constructionwork by main contractors amounted to HK$128.53 billion and contributed HK$65.4 billion (HKGov 2013to the total GDP of HK$1,823.2 billion (3.6% (HKTDC 2013.The aim of this research is toinvestigate which ISO 26000 CSR issues are relevantto HKCI firms. Theprinciple findings are that: the reported level of HKCI CSR activity relativeto the 7 core subject of ISO 26000 is a function of company size; many SME’sconsider that many of the ISO 26000 SR issues are irrelevant to them; but forthe large construction contractors, reputation, legislation and or regulation andcorporate culture are drivers of improvements in CSR in the HKCI.

  6. Iso-precision scaling of digitized mammograms to facilitate image analysis

    International Nuclear Information System (INIS)

    Karssmeijer, N.; van Erning, L.

    1991-01-01

    This paper reports on a 12 bit CCD camera equipped with a linear sensor of 4096 photodiodes which is used to digitize conventional mammographic films. An iso-precision conversion of the pixel values is preformed to transform the image data to a scale on which the image noise is equal at each level. For this purpose film noise and digitization noise have been determined as a function of optical density and pixel size. It appears that only at high optical densities digitization noise is comparable to or larger than film noise. The quantization error caused by compression of images recorded with 12 bits per pixel to 8 bit images by an iso-precision conversion has been calculated as a function of the number of quantization levels. For mammograms digitized in a 4096 2 matrix the additional error caused by such a scale transform is only about 1.5 percent. An iso-precision scale transform can be advantageous when automated procedures for quantitative image analysis are developed. Especially when detection of signals in noise is aimed at, a constant noise level over the whole pixel value range is very convenient. This is demonstrated by applying local thresholding to detect small microcalcifications. Results are compared to those obtained by using logarithmic or linearized scales

  7. [Reform of the Law DIN EN ISO 9001:2000. Commentary on the new requirements on quality management systems].

    Science.gov (United States)

    Eckert, H; Böhmer, K

    2000-09-01

    Since January this year the German translation of the third draft to the reform of the DIN EN ISO 9000 is available. The draft reveals an approximation to the models of Business Excellence. Most important changes are a far stronger customer orientation, orientation on the processes and resource management. The norms DIN EN ISO 9002 and 9003 have been removed, ISO 8402 has been integrated in the reformed DIN EN ISO 9000. Apart from that the compatibility with other management systems has been improved. It was the aim of the reform to improve the applicability for all types of business, products and services.

  8. Iso-suillin isolated from Suillus luteus, induces G1 phase arrest and apoptosis in human hepatoma SMMC-7721 cells.

    Science.gov (United States)

    Jia, Zhi-Qiang; Chen, Ying; Yan, Yong-Xin; Zhao, Jun-Xia

    2014-01-01

    Iso-suillin, a natural product isolated from Suillus luteus, has been shown to inhibit the growth of some cancer cell lines. However, the molecular mechanisms of action of this compound are poorly understood. The purpose of this study was to investigate how iso-suillin inhibits proliferation and induces apoptosis in a human hepatoma cell line (SMMC-7721). We demonstrated the effects of iso-suillin on cell proliferation and apoptosis in SMMC-7721 cells, with no apparent toxicity in normal human lymphocytes, using colony formation assays and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis. Western blotting was used to examine the expression of G1 phase-regulated and apoptosis-associated protein levels in iso-suillin treated SMMC-7721 cells. The results indicated that iso-suillin significantly decreased viability, induced G1 phase arrest and triggered apoptosis in SMMC-7721cells. Taken together, these results suggest the potential of iso-suillin as a candidate for liver cancer treatment.

  9. FROM QUALITY GURUS AND TQM TO ISO 9001:2015: A REVIEW OF SEVERAL QUALITY PATHS

    Directory of Open Access Journals (Sweden)

    Luís Miguel Fonseca

    2015-03-01

    Full Text Available A revision of several paths for the Quality journey is presented: from Quality Gurus and Total Quality Management (TQM models to the ISO 9000 International Standards Series. Since ISO 9001:2008 is now in the revision process to the expected ISO 9001:2015 version, an analysis is made of he proposed changes and the underlying reasons and the impacts foreseen on the more than 1.3 Million certified organizations. This revision should be a step towards TQM and reflect the changes of an increasingly complex, demanding and dynamic environment, while assuring that complying organizations are able to provide conformity products and services that satisfy their customers. Major benefits are expected such as less emphasis on documentation and new/reinforced approaches: consideration of Organizational Context and (relevant Stakeholders, Risk Based thinking and Knowledge Management. Comments and recommendations are presented for organizations wishing to implement or update their Quality Systems accordingly to ISO 9001:2015.

  10. Comparison between ASHRAE and ISO thermal transmittance calculation methods

    DEFF Research Database (Denmark)

    Blanusa, Petar; Goss, William P.; Roth, Hartwig

    2007-01-01

    is proportional to the glazing/frame sightline distance that is also proportional to the total glazing spacer length. An example calculation of the overall heat transfer and thermal transmittance (U-value or U-factor) using the two methods for a thermally broken, aluminum framed slider window is presented....... The fenestration thermal transmittance calculations analyses presented in this paper show that small differences exist between the calculated thermal transmittance values produced by the ISO and ASHRAE methods. The results also show that the overall thermal transmittance difference between the two methodologies...... decreases as the total window area (glazing plus frame) increases. Thus, the resulting difference in thermal transmittance values for the two methods is negligible for larger windows. This paper also shows algebraically that the differences between the ISO and ASHRAE methods turn out to be due to the way...

  11. Study on an ISO 15926 based data modeling methodology for nuclear power industry

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, Yang Ho; Park, Byeong Ho; Park, Seong Chan; Kim, Eun Kee [KEPCO E-C, Yongin (Korea, Republic of)

    2014-10-15

    The scope is therefore data integration and data to support the whole life of a plant. This representation is specified by a generic, conceptual Data Model (DM) that is independent of any particular application, but that is able to record data from the applications used in plant design, fabrication and operation. The data model is designed to be used in conjunction with Reference Data (RD): standard instances of the DM that represent information common to a number of users, plants, or both. This paper introduces a high level description of the structure of ISO 15926 and how this can be adapted to the nuclear power plant industry in particular. This paper introduces ISO 15926 methodology and how to extend the existing RDL for nuclear power industry. As the ISO 15926 representation is independent of applications, interfaces to existing or future applications have to be developed. Such interfaces are provided by Templates that takes input from external sources and 'lifts' it into an ISO 15926 repository, and/or 'lowers' the data into other applications. This is a similar process to the process defined by W3C. Data exchange can be done using e.g. XML messages, but the modelling is independent of technology used for the exchange.

  12. Some considerations on the trunk Simulator ISO: experience in manufacturing, use and maintenance

    International Nuclear Information System (INIS)

    Martins, Marcelo M.; Mauricio, Claudia L.P.

    2013-01-01

    To standardize the operational quantity H p (10), ISO defined a water slab phantom. The conversion factors from air kerma to individual dose equivalent, H p (10), for photon radiation are tabulated in ISO 4037-3, and from neutron fluence 10 H p (10) in ISO 8529-3. This paper presents some considerations concerning the manufacture, use and maintenance of seven ISO water slab phantoms. The experience of the IRD in manufacturing (in its own Mechanical Workshop) and keeping these phantoms and the main advantages and problems encountered during more than 10 years of heavy use, especially for neutron dosimetry, are fully described. An important consideration regarding the interior of the phantom relates to internal cleanliness and quality of the water used to fill it. Another is about the positioning of multiple monitors on a single simulator, including irradiation angles, and the possibility of using multi pie phantoms for isotropic irradiation fields. Finally, it is presented the problems occurred in some phantoms, such as leaks and how to fix them. The two older phantoms, employed exclusively in neutron irradiation, have visible trails of damage in polymethylmethacrylate (PMMA), converging towards its centre, along its front wall, making it more fragile. This is caused by the interaction of radiation with the PMMA. (author)

  13. Novel acyloxy derivatives of branched mono- and polyol esters of sal fat: multiviscosity grade lubricant base stocks.

    Science.gov (United States)

    Kamalakar, Kotte; Sai Manoj, Gorantla N V T; Prasad, Rachapudi B N; Karuna, Mallampalli S L

    2014-12-10

    Sal fat, a nontraditional seed oil, was chemically modified to obtain base stocks with a wide range of specifications that can replace mineral oil base stocks. Sal fatty acids were enriched to 72.6% unsaturation using urea adduct method and reacted with branched mono alcohol, 2-ethylhexanol (2-EtH), and polyols namely neopentyl glycol (NPG) and trimethylolpropane (TMP) to obtain corresponding esters. The esters were hydroxylated and then acylated using propionic, butyric, and hexanoic anhydrides to obtain corresponding acylated derivatives. The acylated TMP esters exhibited very high viscosities (427.35-471.93 cSt at 40 °C) similar to those of BS 150 mineral oil base stock range, ISO VG 460, while the acylated NPG esters (268.81-318.84 cSt at 40 °C) and 2-EtH esters viscosities (20.94-24.44 cSt at 40 °C) exhibited viscosities in the range of ISO VG 320 and 22 respectively with good viscosity indices. Acylated NPG esters were found suitable for high temperature and acylated 2-ethylhexyl esters for low viscosity grade industrial applications. It was observed that the thermo-oxidative stabilities of all acylated products were found better compared to other vegetable oil based base stocks. Overall, all the sal fat based lubricant base stocks are promising candidates with a wide range of properties, which can replace most of the mineral oil base stocks with appropriate formulations.

  14. Is ISO 14001 a Gateway to More Advanced Voluntary Action? A Case for Green Supply Chain Management

    OpenAIRE

    Arimura, Toshi H.; Darnall, Nicole; Katayama, Hajime

    2009-01-01

    Using Japanese facility-level data, we estimate the effects of ISO 14001 certification on the promotion of more advanced practices, namely green supply chain management (GSCM). Our results show that ISO 14001 promotes GSCM practices, in that facilities with environmental management systems (EMS) certified to ISO 14001 are 40 percent more likely to assess their suppliers’ environmental performance and 50 percent more likely to require that their suppliers undertake specific environmental pract...

  15. α-Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid beta 1-42 fibril-induced microglial activation.

    Science.gov (United States)

    Park, Sun Young; Park, Tae Gyeong; Lee, Sang-Joon; Bae, Yoe-Sik; Ko, Min J; Choi, Young-Whan

    2014-01-01

    To examine the antineuroinflammatory and neuroprotective activity of α-iso-cubebenol and its molecular mechanism of action in amyloid β (Aβ) 1-42 fibril-stimulated microglia. Aβ 1-42 fibrils were used to induce a neuroinflammatory response in murine primary microglia and BV-2 murine microglia cell lines. Cell viability was monitored by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, protein expression and phosphorylation were determined by Western blot analysis, and matrix metalloproteinase-9 (MMP-9) activity was determined by gelatin zymography assay. In addition, prostaglandin E2 (PGE2), pro-inflammatory cytokines and chemokines were measured by ELISA, and the transactivity of nuclear factor (NF)-κB was determined by a reporter assay. α-Iso-cubebenol significantly inhibited Aβ 1-42 fibril-induced MMP-9, inducible nitric oxide synthase and cyclooxygenase-2 expressions and activity, without affecting cell viability. α-Iso-cubebenol also suppressed the production of tumour necrosis factor-α, IL-1β, IL-6, monocyte chemoattractant protein-1 and reactive oxygen species in a dose-dependent manner, while decreasing the nuclear translocation and transactivity of NF-κB by inhibiting the phosphorylation and degradation of the inhibitor of κB (IκB)α. α-Iso-cubebenol suppressed the phosphorylation of mitogen-activated protein kinase (MAPK) in Aβ 1-42 fibril-stimulated microglia. Primary cortical neurons were protected by the inhibitory effect of α-iso-cubebenol on Aβ 1-42 fibril-induced neuroinflammatory response. α-Iso-cubebenol suppresses Aβ 1-42 fibril-induced neuroinflammatory molecules in primary microglia via the suppression of NF-κB/inhibitor of κBα and MAPK. Importantly, the antineuroinflammatory potential of α-iso-cubebenol is critical for neuroprotection. © 2013 Royal Pharmaceutical Society.

  16. Iso-suillin from Suillus flavus Induces Apoptosis in Human Small Cell Lung Cancer H446 Cell Line.

    Science.gov (United States)

    Zhao, Jun-Xia; Zhang, Qing-Shuang; Chen, Ying; Yao, Sheng-Jie; Yan, Yong-Xin; Wang, Ying; Zhang, Jin-Xiu; Wang, Li-An

    2016-05-20

    The suillin isoform iso-suillin is a natural substance isolated from a petroleum ether extract of the fruiting bodies of the mushroom Suillus flavus. Previous studies have found its inhibition effect on some cancer cells, and we aimed to study its effects on human small cell lung cancer H446 cell line. Cell viability was measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Cellular morphological changes (apoptosis and necrosis) were evaluated using an electron microscope and Hoechst 33258 staining detected by the inverted microscope. Flow cytometry was used to detect cell apoptosis, cell cycle distribution, and mitochondrial membrane potential. Protein expression was determined by Western blotting analysis. Here, we describe the ability of iso-suillin to inhibit the growth of H446 cells in time- and dose-dependent way. Iso-suillin had no obvious impact on normal human lymphocyte proliferation at low concentrations (9.09, 18.17, or 36.35 μmol/L) but promoted lymphocyte proliferation at a high concentration (72.70 μmol/L). After treatment of different concentrations of iso-suillin (6.82, 13.63, or 20.45 μmol/L), the apoptosis rate of H446 cells increased with increasing concentrations of iso-suillin (16.70%, 35.54%, and 49.20%, respectively, all P iso-suillin could induce H446 cell apoptosis through the mitochondrial pathway and the death-receptor pathway. Therefore, iso-suillin might have a potential application as a novel drug for lung cancer treatment.

  17. Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability.

    Science.gov (United States)

    Gao, Guangxun; Chen, Liang; Li, Jingxia; Zhang, Dongyun; Fang, Yong; Huang, Haishan; Chen, Xiequn; Huang, Chuanshu

    2014-05-15

    The cancer chemopreventive property of Chinese herb new isolate isorhapontigenin (ISO) and mechanisms underlying its activity have never been explored. Here we demonstrated that ISO treatment with various concentrations for 3 weeks could dramatically inhibit TPA/EGF-induced cell transformation of Cl41 cells in Soft Agar assay, whereas co-incubation of cells with ISO at the same concentrations could elicit G0/G1 cell-cycle arrest without redundant cytotoxic effects on non-transformed cells. Further studies showed that ISO treatment resulted in cyclin D1 downregulation in dose- and time-dependent manner. Our results indicated that ISO regulated cyclin D1 at transcription level via targeting JNK/C-Jun/AP-1 activation. Moreover, we found that ISO-inhibited JNK/C-Jun/AP-1 activation was mediated by both upregulation of MKP-1 expression through increasing its mRNA stability and deactivating MKK7. Most importantly, MKP-1 knockdown could attenuate ISO-mediated suppression of JNK/C-Jun activation and cyclin D1 expression, as well as G0/G1 cell cycle arrest and cell transformation inhibition, while ectopic expression of FLAG-cyclin D1 T286A mutant also reversed ISO-induced G0/G1 cell-cycle arrest and inhibition of cell transformation. Our results demonstrated that ISO is a promising chemopreventive agent via upregulating mkp-1 mRNA stability, which is distinct from its cancer therapeutic effect with downregulation of XIAP and cyclin D1 expression.

  18. The Influence of Academic Culture on Quality Management System ISO 9001 Maintenance within Malaysian Universities

    Science.gov (United States)

    Basir, Siti Arni; Davies, John; Douglas, Jacqueline; Douglas, Alexander

    2017-01-01

    This study investigates the influence of the elements of academic culture on quality management system ISO 9001 maintenance within Malaysian universities. There is a dearth of empirical studies on maintaining ISO 9001, particularly in the higher education context. From the literature review, academic culture was classified according to four…

  19. Meta-audit of laboratory ISO accreditation inspections: measuring the old emperor's clothes.

    Science.gov (United States)

    Wilson, Ian G; Smye, Michael; Wallace, Ian J C

    2016-02-01

    Accreditation to ISO/IEC 17025 is required for EC official food control and veterinary laboratories by Regulation (EC) No. 882/2004. Measurements in hospital laboratories and clinics are increasingly accredited to ISO/IEC 15189. Both of these management standards arose from command and control military standards for factory inspection during World War II. They rely on auditing of compliance and have not been validated internally as assessment bodies require of those they accredit. Neither have they been validated to criteria outside their own ideology such as the Cochrane principles of evidence-based medicine which might establish whether any benefit exceeds their cost. We undertook a retrospective meta-audit over 14 years of internal and external laboratory audits that checked compliance with ISO 17025 in a public health laboratory. Most noncompliances arose solely from clauses in the standard and would not affect users. No effect was likely from 91% of these. Fewer than 1% of noncompliances were likely to have consequences for the validity of results or quality of service. The ISO system of compliance auditing has the performance characteristics of a poor screening test. It adds substantially to costs and generates more noise (false positives) than informative signal. Ethical use of resources indicates that management standards should not be used unless proven to deliver the efficacy, effectiveness, and value required of modern healthcare interventions. © 2015 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  20. Safety Signs Perception and Adoption with the ISO and ANSI Standards

    Directory of Open Access Journals (Sweden)

    Amir Hossein Davoudian Talab

    2017-10-01

    Full Text Available Background One way of controlling hazards in the work environment is a use of safety signs. Safety signs are among the safe information group; hence, if these signs are not understood properly it could cause an injury or even death. Objectives The aim of this study is surveying perception of safety signs and adoption with ISO and ANSI standards. Methods This cross-sectional study was conducted during 2013 to 2014 in the 3 provinces of Khuzestan, Fars, and Tehran. The study population included 370 non-monochromatic employees working in the industries. For collecting information, the standard questionnaire of the international organization for standard (ISO 9186-1 and demographic information was used. A total of 13 safety signs were utilized for determination of perception. Stratified - Random sampling method was used, then, the obtained data were utilized using SPSS-16 software and applying descriptive statistics. Results In this study, the overall rate of perception of safety signs was 78.4% with a standard deviation of 15.1%. The lowest percentage of perception was related to the sign “face shield must be worn” (53.5%. In the assessment of safety signs based on ANSI Z5353 and ISO 9186-1 standard, 62.5% and 69.2% of signs can be reached to limit of acceptable perception. Conclusions The perception patterns of safety signs are different. Assessing perception of signs show a moderate level of perception in accordance with ISO standard; however, to reach ANSI standard, implementation of intervention programs (Judgment test is suggested due to perceptual adaptation with target population and redesign of sign with low perception.

  1. Iso-effect tables for tolerance of irradiated normal human tissues

    International Nuclear Information System (INIS)

    Cohen, L.; Creditor, M.

    1983-01-01

    Available literature on a radiation injury to human tissues (lung, brain, kidney and intestine) was surveyed. A parameter search program (RAD3) was used to derive best-fitting cell kinetic parameters, on the assumption that radiation injury arises from depletion of parenchymal cells in the irradiated organs. From these parameters iso-effect tables were constructed for a wide range of treatment schedules, including daily treatment as well as fractionation at longer intervals, for each tissue. The tables provide a set of limiting doses, above which the risk of radiation injury becomes substantial. Tolerance limits and dose-time-factors were substantially different in the four tissues. It is concluded that computed iso-effect tables provide a more reliable guide to treatment than conventional time-dose equations

  2. First results of ISO-SWS observations of Jupiter

    NARCIS (Netherlands)

    Encrenaz, T.; de Graauw, T.; Schaeidt, S.; Lellouch, E.; Feuchtgruber, H.; Beintema, D. A.; Bezard, B.; Drossart, P.; Griffin, M.; Heras, A.; Kessler, M.; Leech, K.; Morris, P.; Roelfsema, P. R.; Roos-Serote, M.; Salama, A.; Vandenbussche, B.; Valentijn, E. A.; Davis, G. R.; Naylor, D. A.

    The spectrum of Jupiter has been recorded between 2.75 and 14.5 mu m with the grating mode of the Short-Wavelength Spectrometer (SWS) of ISO. The resolving power is 1500. The main preliminary results of this observation are (1) at 3 mu m, the first spectroscopic signature, probably associated with

  3. Influencia de la corrupción en la implantación de la ISO 9001

    OpenAIRE

    Olga Rodriguez Arnaldo; Angel R. Martinez Lorente

    2014-01-01

    En las últimas dos décadas, el número de empresas certificadas por ISO 9001 ha ido creciendo constantemente llegando a finales de 2011 a más de 1,1 millones en todo el mundo (ISO, 2012). Sin embargo, la distribución de certificados entre los países no coincide con el peso que cada uno tiene en la economía global. Este artículo comienza con una breve revisión de la literatura sobre las razones por las que las empresas implantan un sistema de gestión que se ajusta a la norma ISO 9001. Esta revi...

  4. 77 FR 71585 - Brookfield Energy Marketing LP v. ISO New England Inc.; Notice of Complaint

    Science.gov (United States)

    2012-12-03

    ... Energy Marketing LP v. ISO New England Inc.; Notice of Complaint Take notice that on November 21, 2012...), Brookfield Energy Marketing LP (Complainant) filed a formal complaint against ISO New England Inc... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

  5. Perceptions About The ISO 9000 Quality System Standard Revision And Its Value: The Dutch Experience

    NARCIS (Netherlands)

    A. van der Wiele (Ton); J.D. van Iwaarden (Jos); A.R.T. Williams (Roger); B.G. Dale (Barry)

    2004-01-01

    textabstractThe aim of the research reported in this paper is to assess the relative value of the 2000 version of the ISO 9000 series of quality management system standards in comparison to the 1994 version. 773 organisations in the Netherlands which have all been certified to the ISO 9000 standard

  6. Elevated plasma 8-iso-prostaglandin F2α levels in human smokers originate primarily from enzymatic instead of non-enzymatic lipid peroxidation.

    Science.gov (United States)

    van 't Erve, Thomas J; Lih, Fred B; Kadiiska, Maria B; Deterding, Leesa J; Mason, Ronald P

    2018-02-01

    It is widely accepted that free radicals in tobacco smoke lead to oxidative stress and generate the popular lipid peroxidation biomarker 8-iso-prostaglandin F 2α (8-iso-PGF 2α ). However, 8-iso-PGF 2α can simultaneously be produced in vivo by the prostaglandin-endoperoxide synthases (PGHS) induced by inflammation. This inflammation-dependent mechanism has never been considered as a source of elevated 8-iso-PGF 2α in tobacco smokers. The goal of this study is to quantify the distribution of chemical- and PGHS-dependent 8-iso-PGF 2α formation in the plasma of tobacco smokers and non-smokers. The influences of gender and hormonal contraceptive use were accounted for. The distribution was determined by measuring the 8-iso-PGF 2α /prostaglandin F 2α (PGF 2α ) ratio. When comparing smokers (n = 28) against non-smokers (n = 30), there was a statistically significant increase in the 8-iso-PGF 2α concentration. The source of this increased 8-iso-PGF 2α was primarily from PGHS. When stratifying for gender, the increase in 8-iso-PGF 2α in male smokers (n = 9) was primarily from PGHS. Interestingly, female smokers on hormonal contraceptives had increased 8-iso-PGF 2α in both pathways, whereas those not on hormonal contraceptives did not have increased 8-iso-PGF 2α . In conclusion, increased plasma 8-iso-PGF 2α in tobacco smokers has complex origins, with PGHS-dependent formation as the primary source. Accounting for both pathways provides a definitive measurement of both oxidative stress and inflammation. Published by Elsevier Inc.

  7. Contribution to Energy Management of the Main Standards for Environmental Management Systems: The Case of ISO 14001 and EMAS

    Directory of Open Access Journals (Sweden)

    Iker Laskurain

    2017-11-01

    Full Text Available The adoption of Energy Management Systems (EnMSs based on international standards has gained momentum since the ISO 50001 standard was launched in 2011. Before that, the potential to improve the energy management with Environmental Management Systems (EMSs based on ISO 14001 and EMAS was identified in the literature. However, no in-depth analysis reported in the literature has explored this claim. The need for research is now even more evident with the development of new versions of the standards for environmental management―ISO 14001:2015 and EMAS III. Since many companies that already have a certified EMSs might be uncertain whether to adopt an ISO 50001 based EnMSs, the present work aims to shed light on the contribution of ISO 14001:2015 and EMAS III to energy management. Furthermore, the work summarizes the results of an empirical exploratory study carried out in eight Spanish organizations, four with an EMS implemented and certified based on ISO 14001:2015 and four more with an EMS registered to EMAS III. The findings show that both ISO14001 and EMAS certified organizations carry out energy management practices, even though they have no formal EnMSs implemented. Implications for managers and policy makers are discussed, together with avenues for further research.

  8. Coeficiente de corrección en engranajes cilíndricos como factor de conversión entre sistemas AGMA e ISO. // Addendum modification coefficient as conversion factor of cylindrical gears in AGMA system to ISO standards.

    Directory of Open Access Journals (Sweden)

    G. González Rey

    2007-09-01

    Full Text Available A partir de la experiencia de los autores, en trabajos asociados con el análisis para la reconversión de engranajes ensistemas AGMA a partir de herramientas con referencia a normas ISO, en el artículo se pretende exponer las principalesdefiniciones y recomendaciones asociadas al coeficiente de corrección relativo al módulo en engranajes cilíndricos de ejesparalelos con dientes de flanco de evolvente que permitan un racional cálculo de la geometría del engranaje y apreciarmediante ejemplos la ventaja del coeficiente de corrección en la solución de problemas prácticos de conversión deengranajes en sistemas AGMA a ISO.Palabras claves: geometría de engranaje cilíndrico, coeficiente de corrección, conversión AGMA a ISO________________________________________________________________________________AbstractDefinitions and recommendations associated to the addendum modification coefficient are presented. Examples, based onauthor’s experiences in the analysis, recovery and conversion of helical and spur gears in AGMA system to ISO standards showthe advantage of application of the addendum modification coefficient in the solution of practical problems and rationalcalculation of gears.Key words: external parallel-axis cylindrical involute gears, gear geometry, , ISO gear standards, rack shift coefficient x

  9. Communication - An Effective Tool for Implementing ISO 14001/EMS

    Energy Technology Data Exchange (ETDEWEB)

    Rachel Damewood; Bowen Huntsman

    2004-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) received ISO 14001/EMS certification in June 2002. Communication played an effective role in implementing ISO 14001/EMS at the INEEL. This paper describes communication strategies used during the implementation and certification processes. The INEEL achieved Integrated Safety Management System (ISMS) and Voluntary Protection Program (VPP) Star status in 2001. ISMS implemented a formal process to plan and execute work. VPP facilitated worker involvement by establishing geographic units at various facilities with employee points of contact and management champions. The INEEL Environmental Management System (EMS) was developed to integrate the environmental functional area into its ISMS and VPP. Since the core functions of ISMS, VPP, and EMS are interchangeable, they were easy to integrate. Communication is essential to successfully implement an EMS. (According to ISO 14001 requirements, communication interacts with 12 other elements of the requirements.) We developed communication strategies that integrated ISMS, VPP, and EMS. For example, the ISMS, VPP, and EMS Web sites communicated messages to the work force, such as “VPP emphasizes the people side of doing business, ISMS emphasizes the system side of doing business, and EMS emphasizes the systems to protect the environment; but they all define work, identify and analyze hazards, and mitigate the hazards.” As a result of this integration, the work force supported and implemented the EMS. In addition, the INEEL established a cross-functional communication team to assist with implementing the EMS. The team included members from the Training and Communication organizations, VPP office, Pollution Prevention, Employee and Media Relations, a union representative, facility environmental support, and EMS staff. This crossfunctional team used various communication strategies to promote our EMS to all organization levels and successfully implemented EMS

  10. Introduction to ISO 15189: a blueprint for quality systems in veterinary laboratories.

    Science.gov (United States)

    Freeman, Kathleen P; Bauer, Natali; Jensen, Asger L; Thoresen, Stein

    2006-06-01

    A trend in human and veterinary medical laboratory management is to achieve accreditation based on international standards. The International Organization for Standardization (ISO) 15189 standard is the first developed especially for accreditation of medical laboratories, and emphasizes the laboratory-client interface. European veterinary laboratories seeking to train candidates for the certification examination of the European College of Veterinary Clinical Pathology (ECVCP) require approval by the ECVCP Laboratory Standards Committee, which bases its evaluation in part on adherence to quality systems described in the ISO 15189 standards. The purpose of this article was to introduce the latest ISO quality standard and describe its application to veterinary laboratories in Europe, specifically as pertains to accreditation of laboratories involved in training veterinary clinical pathologists. Between 2003 and 2006, the Laboratory Standards Committee reviewed 12 applications from laboratories (3 commercial and 9 university) involved in training veterinary clinical pathologists. Applicants were asked to provide a description of the facilities for training and testing, current methodology and technology, health and safety policy, quality assurance policy (including internal quality control and participation in an external quality assurance program), written standard operating procedures (SOPs) and policies, a description of the laboratory information system, and personnel and training. Also during this time period multiple informal and formal discussions among ECVCP diplomates took place as to current practices and perceived areas of concern with regard to laboratory accreditation requirements. Areas in which improvement most often was needed in veterinary laboratories applying for ECVCP accreditation were the written quality plan, defined quality requirements for the tests performed, written SOPs and policies, training records, ongoing audits and competency

  11. ISO 9001:2000--setting the standard for quality management.

    Science.gov (United States)

    Edelstein, M E

    2001-04-01

    How will you approach the next quality management initiative? This article offers an introduction to the ISO 9001:2000 quality management system standards that can be applied to the HIM industry and how these standards can improve your department's policies and procedures.

  12. Manufacturing Bms/Iso System Review

    Science.gov (United States)

    Gomez, Yazmin

    2004-01-01

    The Quality Management System (QMS) is one that recognizes the need to continuously change and improve an organization s products and services as determined by system feedback, and corresponding management decisions. The purpose of a Quality Management System is to minimize quality variability of an organization's products and services. The optimal Quality Management System balances the need for an organization to maintain flexibility in the products and services it provides with the need for providing the appropriate level of discipline and control over the processes used to provide them. The goal of a Quality Management System is to ensure the quality of the products and services while consistently (through minimizing quality variability) meeting or exceeding customer expectations. The GRC Business Management System (BMS) is the foundation of the Center's ISO 9001:2000 registered quality system. ISO 9001 is a quality system model developed by the International Organization for Standardization. BMS supports and promote the Glenn Research Center Quality Policy and wants to ensure the customer satisfaction while also meeting quality standards. My assignment during this summer is to examine the manufacturing processes used to develop research hardware, which in most cases are one of a kind hardware, made with non conventional equipment and materials. During this process of observation I will make a determination, based on my observations of the hardware development processes the best way to meet customer requirements and at the same time achieve the GRC quality standards. The purpose of my task is to review the manufacturing processes identifying opportunities in which to optimize the efficiency of the processes and establish a plan for implementation and continuous improvement.

  13. Pengaruh Sistem Manajemen Iso 9001:2008 Terhadap Pelayanan Kefarmasian Di Puskesmas Kabupaten Sleman

    OpenAIRE

    Aji Wibowo, Much Ilham Novalisa; Munawaroh, Siti; Purnama, Cahya

    2015-01-01

    The vision of health development organized by the district health center is achieving district healthy. The need for improving the quality of health services in health centers contained in the WHO Annual Report 2008 under the title "Primary Health Care, Now More Than Ever". The efforts to improve the quality of services in health centers is ISO 9001:2008 certification at the International level. ISO 9001 certification is expected to improve the quality of pharmacy services at health centers. ...

  14. The Purpose of ISO 14001 Certification: Independent Assurance or Improved Environmental Management System?

    Directory of Open Access Journals (Sweden)

    Janet Morrill

    2012-12-01

    Full Text Available This study provides evidence of the value of third party certification of environmental management systems. We examine the relative importance of improving an environmental management system as a result of certification, versus being able to communicate the quality of that system credibly to outsiders through third party certification. We use survey data where one half of the respondents had indicated that they had an environmental management (EMS in place before seeking ISO 14001 certification, while the other half of respondents did not. Our analyses comparing the two groups find that the group already having an EMS report similar motivations for ISO 14001 certification and perceive to have received similar levels of benefits as firms having no pre-certification EMS. We conclude that even for organizations that already have an EMS, the ability to communicate credibly the quality of that system is a compelling reason to obtain ISO certification.

  15. Impact of Supplier Management Strategies on the Organizational Performance of ISO 9001 Certified Organizations

    OpenAIRE

    Fonseca, Luis Miguel; Lima, Vanda Marlene

    2015-01-01

    Purpose: The purpose of this article is to discuss the impact of Supplier orientation and the resulting Supply Chain Management (SCM) approach, on the organizational performance of ISO 9001 Quality Management Systems certified organizations. Methodology/Approach: Following a literature review, a full structural conceptual model was proposed. An online survey was administered to managers of Portuguese organizations with certified ISO 9001 Quality Management Systems. Descriptive Statistics a...

  16. Thirty years of international nuclear standards in ISO and IEC

    International Nuclear Information System (INIS)

    Becker, K.

    1991-01-01

    Of over 4700 nuclear and radiation protection standards, laws, regulations, recommendations, etc., which have been issued by 52 countries and several governmental international organizations such as IAEA, or non-government organizations such as ICRP, ICRU, ISO and IEC, more than 90% are national, and more than half of those of a non-regulatory nature. Both number and importance of international standards are, however, increasing. The two most important non-governmental international standards organizations are the International Organization for Standardization (ISO), which founded a Technical Committee (TC) 85 'Nuclear Energy' with several Sub-Committees in 1957, and the closely associated International Electrotechnical Commission (IEC) with its TC 45 'Nuclear Instrumentation' formed in 1960. There are over 20 member countries actively participating in the work in each of them, with additional observer countries and liaison to the relevant other international organizations. A brief review is given on some of the experience which has been gained by ISO/TC 85 and IEC/TC 45, and its work program and accomplishments, considering in particular recent developments. It covers nuclear safety and instrumentation, radiation protection, and the nuclear fuel cycle, as well as interface issues including definitions and terminology, interaction of the activities with the work of other national and international bodies, etc. Some problem areas are also briefly discussed. (orig.)

  17. Implementation of ISO 17025 in the Eletronuclear Environmental Monitoring Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Baliza, Ana Rosa; Caetano, Carla de Brito, E-mail: baliza@eletronuclear.gov.br [Eletrobrás Termonuclear S.A. (ELETRONUCLEAR), Angra dos Reis, RJ (Brazil)

    2017-07-01

    In order to grant Angra 3 power plant operation license, the Brazilian Institute for the Environment and Renewable Natural Resources (IBAMA), in the IBAMA Installation License 591/2009 condition 2.24, required that Eletronuclear has to obtain the Environmental Monitoring Laboratory accreditation, in accordance with the requirements of NBR ISO / IEC 17025 standard. The accreditation is the formal recognition that a laboratory has a quality assurance system and technical competence to perform specific tests, evaluated according to the criteria based on NBR ISO/IEC 17025 (General requirements for testing and calibration laboratories competence) standard. In Brazil, the General Accreditation Coordination (CGCRE), according to the guidelines already explained by the Brazilian System of Conformity Assessment (INMETRO), does accreditation. The INMETRO is the only official accrediting body in Brazil and internationally recognized by the International Accreditation Forum (IAF). The Environmental Monitoring Laboratory at Eletronuclear is an analytical laboratory of chemical, radiochemical and biological tests, which analyzes several matrices, such as seawater, river water, marine sediment, beach sand, soil, pasture, banana, milk, besides marine sea life, around the Central Almirante Álvaro Alberto power plant station. It is licensed by CNEN, INEA, IBAMA and it follows national and international standards in the performance of the tests as well as in the collection and preparation of samples. This article describes the main steps that the Eletronuclear Environmental Monitoring Laboratory followed to implement ISO 17025. (author)

  18. Implementation of ISO 17025 in the Eletronuclear Environmental Monitoring Laboratory

    International Nuclear Information System (INIS)

    Baliza, Ana Rosa; Caetano, Carla de Brito

    2017-01-01

    In order to grant Angra 3 power plant operation license, the Brazilian Institute for the Environment and Renewable Natural Resources (IBAMA), in the IBAMA Installation License 591/2009 condition 2.24, required that Eletronuclear has to obtain the Environmental Monitoring Laboratory accreditation, in accordance with the requirements of NBR ISO / IEC 17025 standard. The accreditation is the formal recognition that a laboratory has a quality assurance system and technical competence to perform specific tests, evaluated according to the criteria based on NBR ISO/IEC 17025 (General requirements for testing and calibration laboratories competence) standard. In Brazil, the General Accreditation Coordination (CGCRE), according to the guidelines already explained by the Brazilian System of Conformity Assessment (INMETRO), does accreditation. The INMETRO is the only official accrediting body in Brazil and internationally recognized by the International Accreditation Forum (IAF). The Environmental Monitoring Laboratory at Eletronuclear is an analytical laboratory of chemical, radiochemical and biological tests, which analyzes several matrices, such as seawater, river water, marine sediment, beach sand, soil, pasture, banana, milk, besides marine sea life, around the Central Almirante Álvaro Alberto power plant station. It is licensed by CNEN, INEA, IBAMA and it follows national and international standards in the performance of the tests as well as in the collection and preparation of samples. This article describes the main steps that the Eletronuclear Environmental Monitoring Laboratory followed to implement ISO 17025. (author)

  19. Performance of two updated blood glucose monitoring systems: an evaluation following ISO 15197:2013.

    Science.gov (United States)

    Pleus, Stefan; Baumstark, Annette; Rittmeyer, Delia; Jendrike, Nina; Haug, Cornelia; Freckmann, Guido

    2016-05-01

    Objective For patients with diabetes, regular self-monitoring of blood glucose (SMBG) is essential to ensure adequate glycemic control. Therefore, accurate and reliable blood glucose measurements with SMBG systems are necessary. The international standard ISO 15197 describes requirements for SMBG systems, such as limits within which 95% of glucose results have to fall to reach acceptable system accuracy. The 2013 version of this standard sets higher demands, especially regarding system accuracy, than the currently still valid edition. ISO 15197 can be applied by manufacturers to receive a CE mark for their system. Research design and methods This study was an accuracy evaluation following ISO 15197:2013 section 6.3 of two recently updated SMBG systems (Contour * and Contour TS; Bayer Consumer Care AG, Basel, Switzerland) with an improved algorithm to investigate whether the systems fulfill the requirements of the new standard. For this purpose, capillary blood samples of approximately 100 participants were measured with three test strip lots of both systems and deviations from glucose values obtained with a hexokinase-based comparison method (Cobas Integra † 400 plus; Roche Instrument Center, Rotkreuz, Switzerland) were determined. Percentages of values within the acceptance criteria of ISO 15197:2013 were calculated. This study was registered at clinicaltrials.gov (NCT02358408). Main outcome Both updated systems fulfilled the system accuracy requirements of ISO 15197:2013 as 98.5% to 100% of the results were within the stipulated limits. Furthermore, all results were within the clinically non-critical zones A and B of the consensus error grid for type 1 diabetes. Conclusions The technical improvement of the systems ensured compliance with ISO 15197 in the hands of healthcare professionals even in its more stringent 2013 version. Alternative presentation of system accuracy results in radar plots provides additional information with certain advantages. In addition

  20. Zhodnocení připravenosti podniku na zavedení ISO 27001 pomocí GAP analýzy

    OpenAIRE

    Zrcek, Tomáš

    2016-01-01

    The aim of the thesis is to evaluate the preparedness of an information security management system (ISMS) in a logistic company JASA s.r.o. for a certification by standard ISO/IEC 27001:2013. This enterprise oscillates between small and medium enterprise. It has already implemented the certificate on quality management ISO 9001:2008. For this reason, in the thesis there are presented advantages for a company that already has implemented one of ISO standards and decides to implement another. F...

  1. ÜRETİM SEKTÖRÜNDE FAALİYET GÖSTEREN KOBİLERDE ISO 9000’NİN ETKİLİ UYGULAMASI İÇİN KRİTİK BAŞARI FAKTÖRLERİ (CRITICAL SUCCESS FACTORS FOR EFFECTIVE IMPLEMENTATION OF ISO 9000 IN SME’S OPERATING IN MANUFACTURING SECTOR

    Directory of Open Access Journals (Sweden)

    Adnan KALKAN

    2012-07-01

    Full Text Available ISO 9000 for quality is one of the most applicable strategies by businesses all over the world. ISO 9000 has been one of important issues in many developing countries including Turkey. Up to now less study is published on the successful use of ISO 9000 Quality Management System, critical success factors and application problems in SME’s. The purpose of this study is to investigate the critical success factors for the effective implementation of ISO 9000 standard in small and medium-sized enterprises (SME’s operating in the manufacturing sector in Turkey.This empirical study has been carried out with a sample of 246 ISO 9000-certified SME’s selected from enterprises operating in manufacturing sector in Turkey. Data were obtained by a questionnaire survey of the managers responsible for quality in each of the sample SME’s. Critical success factors for the effective implementation of ISO 9000 were assessed for importance by simple descriptive statistics.This study provides practical guidance for SME’s operating in manufacturing sector and seeking to implement the ISO 9000 standard effectively.

  2. Present Situation and Activities of ISO 14000 series in Heavy Machinery Industries; Jukikai meka no taiou jokyo

    Energy Technology Data Exchange (ETDEWEB)

    Tomisawa, Yukio. [Ishikawajima-Harima Heavy Industries Corp., Tokyo (Japan). Research Institute

    1999-01-15

    This paper shows the outline of the present situation and activities of ISO14000 series, environmental management system in heavy machinery industries. Today, main heavy machinery industries have already certified to ISO 14001 until this summer. The aim of the introduction of ISO 14001 are to establish the system improvement continuously by PDCA, to have essential elements in international trade and to keep up with the risk management. Some example of conducted ISO 14001 in heavy machinery industries are shown. The trend of heavy machinery industries will be able to predict to three key words, internationalization, network and opening information. The new role expected to environmental material engineer are indicated to research and develop ecomaterial by using LCA and to support the recycling, waste treatment and other technical basis of the environmental management system. (author)

  3. The Post-polyketide Synthase Steps in iso-Migrastatin Biosynthesis Featuring Tailoring Enzymes with Broad Substrate Specificity

    Science.gov (United States)

    Ma, Ming; Kwong, Thomas; Lim, Si-Kyu; Ju, Jianhua; Lohman, Jeremy R.; Shen, Ben

    2013-01-01

    The iso-migrastatin (iso-MGS) biosynthetic gene cluster from Streptomyces platensis NRRL 18993 consists of 11 genes, featuring an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes MgsIJK. Systematic inactivation of mgsIJK in S. platensis enabled us to (i) identify two nascent products (10 and 13) of the iso-MGS AT-less type I PKS, establishing an unprecedented novel feature for AT-less type I PKSs, and (ii) account for the formation of all known post-PKS biosynthetic intermediates (10-17) generated by the three tailoring enzymes MgsIJK, which possessed significant substrate promiscuities. PMID:23394593

  4. Applicability of ISO 16697 Data to Spacecraft Fire Fighting Strategies

    Science.gov (United States)

    Hirsch, David B.; Beeson, Harold D.

    2012-01-01

    Presentation Agenda: (1) Selected variables affecting oxygen consumption during spacecraft fires, (2) General overview of ISO 16697, (3) Estimated amounts of material consumed during combustion in typical ISS enclosures, (4) Discussion on potential applications.

  5. The development of ISO freight containers as IP-2 packagings

    International Nuclear Information System (INIS)

    Janicki, M.C.; Vaughan, R.A.

    1993-01-01

    Design specifications were developed for ISO freight containers to meet the requirements of the transport regulations in the 1985 Edition of IAEA SS6, and to maximize the technical and commercial benefits offered to consignors by this type of container for the transport and handling of bulk LSA/SCO materials. A range of IP-2 ISO freight containers have been designed and built to these specifications and are in use in the UK. This paper discusses the regulatory considerations which had to be reviewed and interpreted in developing freight containers as Industrial Package Type 2 (IP-2) packagings and the development of performance standards to meet the regulatory requirements. Outline details of the packages developed are indicated together with examples of handling equipment developed to facilitate loading and unloading. (J.P.N.)

  6. Cotation de fabrication avec les normes ISO

    CERN Document Server

    Anselmetti, Bernard

    2010-01-01

    La cotation ISO en production impose de nouvelles méthodologies pour élaborer les documents de maîtrise de la qualité géométrique des produits : les dessins de phase, du brut et d'états intermédiaires pour la conformité des pièces et les fiches de production, de réglage, de contrôle et de surveillance pour la conformité des moyens de production. Une méthode de transfert unidirectionnelle simple permet d'établir des dessins de phase en normes ISO et d'optimiser la répartition des tolérances à isocapabilité. Cette cotation est déclinée en cotation d'état intermédiaire, de production et de réglage. Une méthode tridimensionnelle est proposée pour prendre en compte les effets des défauts angulaires. Une maquette montre les fonctionnalités envisageables pour les futurs outils d'aides au tolérancement de fabrication au sein de la CFAO. De nombreux exercices illustrent les différentes démarches. Ce Manuel de tolérancement est principalement destiné aux préparateurs méthodes et aux c...

  7. Department of Defense Quality Management Systems and ISO 9000:2000

    National Research Council Canada - National Science Library

    Lucius, Tommie

    2002-01-01

    The purpose of the research is to examine and evaluate the emergence of the International Organization for Standardization, commonly referred to as ISO, quality standard for the year 2000 as it applies (past and present...

  8. Norma ISO 690:2010 [Doctorado. 2015

    OpenAIRE

    Biblioteca Universitaria

    2015-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  9. Norma ISO 690:2010 [Doctorado. 2017

    OpenAIRE

    Biblioteca Universitaria

    2017-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  10. Norma ISO 690:2010 [Doctorado. 2014

    OpenAIRE

    Biblioteca Universitaria

    2014-01-01

    Mediante el estudio de este tema aprenderás a gestionar adecuadamente tu bibliografía adquiriendo una serie de competencias que te permitirán: - Actuar de manera responsable, ética y legal en el uso de la información empleada para realizar un trabajo académico. - Identificar el estilo de cita más adecuado para cada disciplina científica. - Identificar correctamente y elaborar las referencias bibliográficas correspondientes a distintos tipos de documentos, de acuerdo con la norma ISO 690:2010....

  11. The Effect of n vs. iso Isomerization on the Thermophysical Properties of Aromatic and Non-aromatic Ionic Liquids.

    Science.gov (United States)

    Rodrigues, Ana S M C; Almeida, Hugo F D; Freire, Mara G; Lopes-da-Silva, José A; Coutinho, João A P; Santos, Luís M N B F

    2016-09-15

    This work explores the n vs. iso isomerization effects on the physicochemical properties of different families of ionic liquids (ILs) with variable aromaticity and ring size. This study comprises the experimental measurements, in a wide temperature range, of the ILs' thermal behavior, heat capacities, densities, refractive indices, surface tensions, and viscosities. The results here reported show that the presence of the iso -alkyl group leads to an increase of the temperature of the glass transition, T g . The iso- pyrrolidinium (5 atoms ring cation core) and iso -piperidinium (6 atoms ring cation core) ILs present a strong differentiation in the enthalpy and entropy of melting. Non-aromatic ILs have higher molar heat capacities due to the increase of the atomic contribution, whereas it was not found any significant differentiation between the n and iso -alkyl isomers. A small increase of the surface tension was observed for the non-aromatic ILs, which could be related to their higher cohesive energy of the bulk, while the lower surface entropy observed for the iso isomers indicates a structural resemblance between the IL bulk and surface. The significant differentiation between ILs with a 5 and 6 atoms ring cation in the n -alkyl series (where 5 atoms ring cations have higher surface entropy) is an indication of a more efficient arrangement of the non-polar region at the surface in ILs with smaller cation cores. The ILs constituted by non-aromatic piperidinium cation, and iso -alkyl isomers were found to be the most viscous among the studied ILs due to their higher energy barriers for shear stress.

  12. Audit Capability EAM menggunakan COBIT 5 dan ISO 55002 pada Perusahaan Kelistrikan Negara

    Directory of Open Access Journals (Sweden)

    Ni Kadek Rahayu Widya Utami

    2016-12-01

    Full Text Available Manajemen aset distribusi merupakan sistem komputerisasi terpadu yang dapat membantu optimalisasi kegiatan maintenance dengan mengatur, menjadwalkan, merencanakan kegiatan pemeliharaan sumber daya sesuai dengan tujuan perusahaan. PT.X sebagai perusahaan pengelola kelistrikan di Bali, saat ini melakukan penggabungan antara pengelolaan aset distribusi perusahaan dengan teknologi informasi yang menghasilkan EAM. Penerapan audit capability manajemen aset distribusi yang belum pernah dilakukan PT.X menjadi alasan dilakukannya penelitian ini. Audit capability dilakukan untuk mengetahui tingkat kematangan sistem serta melakukan analisis kondisi eksisting dari manajemen aset distribusi dalam perannya memenuhi tujuan perusahaan. COBIT 5 dan ISO 55002 digunakan sebagai panduan untuk melakukan analisa terhadap kelayakan sebuah investasi teknologi informasi yang sudah dilakukan oleh sebuah perusahaan. Hasil dari audit terpilih 3 domain yakni EDM 02, EDM 05 dan APO 11 yang menjadi domain evaluasi capability level dengan analisis GAP pada setiap domainnya. Penyusunan rekomendasi menggunakan 7 klausul ISO 55002 untuk penerapan manajemen aset distribusi yang lebih baik. Kata Kunci: Manajemen Aset Distribusi, Capability Level COBIT 5, GAP, ISO 55002

  13. Implementace novelizované normy ISO 10006 ve spolecnosti UNICORN a.s.

    OpenAIRE

    Havlín, Jan

    2008-01-01

    Diplomová práce zpracovává analýzu současného stavu řízení projektů ve společnosti UNICORN a.s. a navrhuje doporučení ke zlepšení v této oblasti na základě ČSN ISO 10 006 Systému managementu jakosti - Směrnice pro management jakosti projektů. This Thesis looks at the current situation in the UNICORN a.s. company and analyses how the projects are managed in the company. The Thesis suggests recommendation for improvements in this field according to ČSN ISO 10 006 Quality Management Systems -...

  14. Is ISO 14001 Certification Effective? An Experimental Analysis of Firm Profitability

    Directory of Open Access Journals (Sweden)

    Aridelmo José Campanharo Teixeira

    2012-05-01

    Full Text Available This paper examines the effect environmental management certification (ISO 14001 has on publicly tradedBrazilian companies profitability. Signaling theory predicts that the certification serves to signal to society goodenvironmental behavior; allowing people to screen the different types of firms, improving the financialeconomicperformance of those firms that engage in this behavior. We performed difference-in-difference fixedeffect design comparing the financial performance of companies with and without certification of theirenvironmental management systems, using data on 552 companies over the period from 1996 to 2008. Theresults indicate that firms with an environmental management system certified according to the NBR ISO14001:2004 standard tended to be more profitable, on average, than firms without certification.

  15. 78 FR 32384 - New England Power Generators Association v. ISO New England Inc.; Notice of Complaint

    Science.gov (United States)

    2013-05-30

    ... Power Generators Association v. ISO New England Inc.; Notice of Complaint Take notice that on May 17... New England Power Generators Association (Complainant) filed a formal complaint against ISO New...., Washington, DC 20426. This filing is accessible on-line at http://www.ferc.gov , using the ``eLibrary'' link...

  16. Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut

    DEFF Research Database (Denmark)

    Pipek, Orsolya; Ribli, Dezső; Molnar, Janos

    2017-01-01

    for testing purposes. Optimal values of the filtering parameters of IsoMut were determined in a thorough and strict optimization procedure based on these test sets. We show that IsoMut, when tuned correctly, decreases the false positive rate compared to conventional tools in a 30 sample experimental setup...

  17. What’s Next: The Status of ISO Global KM Standards and the Importance of Managing Knowledge Assets

    International Nuclear Information System (INIS)

    Young, R.

    2016-01-01

    Full text: Ron Young, CEO of Knowledge Associates International, based in Cambridge UK, is Chair of the BSI KM Standards Committee KMS/1, member of the BSI Asset Management Committee AMS/1 working with ISO 55000, and member of the ISO 30401 workgroup developing a global KM Standard. He will present the benefits, challenges and implications of a global KM standard, from his perspective, and give an update on the ISO/BSI standard development. He will also provide insights into the latest developments with knowledge asset management. (author

  18. The Social Shaping of Environmental Mangement based on ISO 14001 in Danish and Thai Textile and Garment Sectors

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Chandrachai, A.; Bunbongkarn, C.

    2003-01-01

    The social shaping of ISO 14001 in Danish and Thai textile and garment sectors is discussed based on Danish case studies and evaluations and a Thai focus group interview. The precentage of ISO 14001 certified companies in the sectors are five times higher in Denmark, but covers only around 5...... about the interpretation of the regulation. In Denmark problems with the balance between consultant support and company-internal competence development are seen. The focus of ISO 14001 is more life cycle oriented in Denmark due to international policy and the manufacturing of textile and garment outside...... Denmark. A combined focus on ISO 14001 covering the interests of the companies in industrialised, developing and newly industrialised countries might be found through negotiations....

  19. ISO-9001: An approach to accreditation for an MTR facility: SAFARI-1 research reactor

    International Nuclear Information System (INIS)

    Piani, C.S.B.; Du Bruyn, J.F.B.

    2000-01-01

    The SAFARI-1 Research Reactor obtained ISO-9001 accreditation via the South African Bureau of Standards in September 1998. In view of the commercial applications of the reactor, the value of acquisition of the accreditation was considered against the cost of implementation of the Quality System. The criteria identified in the ISO-9001 standard were appraised and a superstructure derived for management of the generation and implementation of a suitable Quality Management System (QMS) for the fairly unique application of a nuclear research reactor. A Quality Policy was established, which formed the basis of the QMS against which the various requirements and/or standards were identified. In addition, since it was considered advantageous to incorporate the management controls of Conventional and Radiological Safety as well as Plant Maintenance and Environmental Management (ISO 14001), these aspects were included in the QMS. (author)

  20. Applying and extending ISO/TC42 digital camera resolution standards to mobile imaging products

    Science.gov (United States)

    Williams, Don; Burns, Peter D.

    2007-01-01

    There are no fundamental differences between today's mobile telephone cameras and consumer digital still cameras that suggest many existing ISO imaging performance standards do not apply. To the extent that they have lenses, color filter arrays, detectors, apertures, image processing, and are hand held, there really are no operational or architectural differences. Despite this, there are currently differences in the levels of imaging performance. These are driven by physical and economic constraints, and image-capture conditions. Several ISO standards for resolution, well established for digital consumer digital cameras, require care when applied to the current generation of cell phone cameras. In particular, accommodation of optical flare, shading non-uniformity and distortion are recommended. We offer proposals for the application of existing ISO imaging resolution performance standards to mobile imaging products, and suggestions for extending performance standards to the characteristic behavior of camera phones.

  1. From an equilibrium based MOF adsorbent to a kinetic selective carbon molecular sieve for paraffin/iso-paraffin separation

    KAUST Repository

    Li, Baiyan

    2016-11-04

    We unveil a unique kinetic driven separation material for selectively removing linear paraffins from iso-paraffins via a molecular sieving mechanism. Subsequent carbonization and thermal treatment of CD-MOF-2, the cyclodextrin metal-organic framework, afforded a carbon molecular sieve with a uniform and reduced pore size of ca. 5.0 Å, and it exhibited highly selective kinetic separation of n-butane and n-pentane from iso-butane and iso-pentane, respectively. © The Royal Society of Chemistry.

  2. Application of the user-centred design process according ISO 9241-210 in air traffic control.

    Science.gov (United States)

    König, Christina; Hofmann, Thomas; Bruder, Ralph

    2012-01-01

    Designing a usable human machine interface for air traffic control is challenging and should follow approved methods. The ISO 9241-210 standard promises high usability of products by integrating future users and following an iterative process. This contribution describes the proceeding and first results of the analysis and application of ISO 9241-210 to develop a planning tool for air traffic controllers.

  3. Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation.

    Science.gov (United States)

    van 't Erve, Thomas J; Lih, Fred B; Kadiiska, Maria B; Deterding, Leesa J; Eling, Thomas E; Mason, Ronald P

    2015-06-01

    The biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) is regarded as the gold standard for detection of excessive chemical lipid peroxidation in humans. However, biosynthesis of 8-iso-PGF2α via enzymatic lipid peroxidation by prostaglandin-endoperoxide synthases (PGHSs), which are significantly induced in inflammation, could lead to incorrect biomarker interpretation. To resolve the ambiguity with this biomarker, the ratio of 8-iso-PGF2α to prostaglandin F2α (PGF2α) is established as a quantitative measure to distinguish enzymatic from chemical lipid peroxidation in vitro, in animal models, and in humans. Using this method, we find that chemical lipid peroxidation contributes only 3% to the total 8-iso-PGF2α in the plasma of rats. In contrast, the 8-iso-PGF2α levels in plasma of human males are generated >99% by chemical lipid peroxidation. This establishes the potential for an alternate pathway of biomarker synthesis, and draws into question the source of increases in 8-iso-PGF2α seen in many human diseases. In conclusion, increases in 8-iso-PGF2α do not necessarily reflect increases in oxidative stress; therefore, past studies using 8-iso-PGF2α as a marker of oxidative stress may have been misinterpreted. The 8-iso-PGF2α/PGF2α ratio can be used to distinguish biomarker synthesis pathways and thus confirm the potential change in oxidative stress in the myriad of disease and chemical exposures known to induce 8-iso-PGF2α. Published by Elsevier Inc.

  4. ISO 9000 and quality standards improvement in the maintenance ...

    African Journals Online (AJOL)

    This study investigated ISO 9000 as a tool for improving quality standards in ... The study used cross-sectional descriptive research design, using quantitative research ... enhance business performance and competiveness of manufacturing firms. ... By Country · List All Titles · Free To Read Titles This Journal is Open Access.

  5. The ISO 14001 Environmental Management Systems as a Motivation

    African Journals Online (AJOL)

    user1

    Two case studies were selected namely Plant A (a dairy plant) ... ISO 14001 certified and it is making use these indicators for its energy and .... community, public health, skills and education, social justice, workplace safety ..... Plant A holds good relations with its neighbourhood community. ... The plant sponsors its nearby.

  6. Direct synthesis of iso-butane from synthesis gas or CO2 over CuZnZrAl/Pd-β hybrid catalyst

    Directory of Open Access Journals (Sweden)

    Congming Li

    2017-12-01

    Full Text Available The effect of various factors on the catalytic performance of iso-butane formation over CuZnZrAl/Pd-β hybrid catalyst via synthesis gas or CO2 hydrogenation has been deeply investigated in this work. It was interesting to note that the iso-butane/n-butane ratio value was much higher than that of thermodynamic equilibrium (about 1/1, whose value was directly related to the reaction condition using this hybrid catalyst. In order to further clearly clarify this finding, various experimental reaction factors were selected to investigate the formation of iso-butane. The results revealed that increasing temperature, H2/COx, CO2/COx, and/or Pd loading possessed an inhibiting effect on the iso-butane yield. High selectivity of iso-butane could be achieved by increasing the reaction pressure, W/F and the weight ratio of CuZnZrAl methanol catalyst to Pd-β catalyst. It is also noted that the addition of water seriously suppressed the reaction activity, resulting in the low ratio of iso-butane/n-butane. A possible reaction route was elucidated based on the latest results. This might shed light on the development of a high efficient catalyst for iso-butane production from synthesis gas or CO2 hydrogenation. Keywords: Iso-butane, Synthesis gas, CO2, CuZnZrAl/Pd-β hybrid catalyst

  7. Department of Defense Quality Management Systems and ISO 9000:2000

    National Research Council Canada - National Science Library

    Lucius, Tommie

    2002-01-01

    ...) to the Department of Defense (DoD) quality management system (QMS) in procurement. In particular, the researcher will examine the new standard and its utility for DoD procurement, focusing on changes from the previous ISO 9000 series...

  8. Evaluation of the Effectiveness of ISO14001 on Hospital Wastes Management Using AHP in Tehran Hospitals

    Directory of Open Access Journals (Sweden)

    Mohammad Noorisepehr

    2014-06-01

    Full Text Available Background: Lack of enough supervision, wrong and partial planning in the part of hospital residuals management cause high volume of production from variety of residuals which controlling them impose high costs to every society. In order to improve hospital wastes management, implementing a system of environmental management like ISO14001 can improve the environmental performance of organization and introduce the ways of solving problems to managers. The main objective of this study was to identify and prioritize the effective factors in the implementation of ISO 14001 and the benefits of its implementation in hospitals of Tehran. Methods: In this study, after the identification of success factors and benefits of ISO 14001 implementation in hospitals of Tehran, the method of analytical hierarchy process is used in order to understand the importance and relative priority of these successful important factors and their benefits. Results: Results show that the most important successful factors, based on the importance, are management commitment, education and training, communications and community relations and documentation and control.  Also, the most important benefits, of ISO 14001 implementation, are cost reduction in waste management, increasing the awareness and commitment of staff, risk management practices improvement and work process and procedures improvement. Conclusion: Findings of the study indicate that which success factors of ISO 14001 requires more attention by managers and are in priority while implementing them.

  9. Manufacturing of the ISO 25178-70 material measures with direct laser writing: a feasibility study

    Science.gov (United States)

    Eifler, M.; Hering, J.; von Freymann, G.; Seewig, J.

    2018-06-01

    The standard ISO 25178-70 defines material measures for the calibration of 2D- and 3D-topography measurement devices. Some of the suggested material measures are established within the industrial application for a long time while others have not yet been extensively researched regarding their practical abilities. This paper describes a holistic and systematic investigation of the ISO 25178-70 material measures. The manufacturing of the suggested geometries is executed with two-photon laser lithography, alias direct laser writing (DLW). Since this manufacturing process is not yet frequently used in a material measures context, it is examined regarding its suitability for the fabrication of the ISO 25178-70 material measures. With DLW, it is possible to manufacture multiple material measures on one sample in order to enable a comprehensive calibration of optical topography measurement devices. The manufactured ISO 25178-70 geometries are examined using different 3D-topography measuring devices. In doing so, their abilities regarding the calibration of the devices can be evaluated and the practical feasibility of their industrial application is assessed. For the review of this practical usefulness, varying calibration and evaluation strategies are taken into account.

  10. Electrochemical and stress corrosion cracking behaviour of titanium in n-propanol and iso-propanol solutions

    International Nuclear Information System (INIS)

    Trasatti, S.P.; Sivieri, E.

    2004-01-01

    Titanium shows severe localised corrosion in non-aqueous media in the presence of applied stress and crevice. The present work brings a contribution to the behaviour of Ti in non-aqueous media by studying the role of water on the electrochemical properties and stress corrosion cracking (SCC) sensitivity of Ti in n-propanol and iso-propanol solutions. The anodic behaviour of titanium in n-propanol-H 2 O and iso-propanol-H 2 O systems is quite similar to that observed in methanol-H 2 O and ethanol-H 2 O systems. The minimum water content needed for the passive film to be stable is 2% for n-propanol and 0.1% for iso-propanol. In methanol and ethanol it is 20 and 8%, respectively. The minimum water content decreases as the number of carbon atoms increases and the lowest water content in iso-propanol is strictly related to the capability of the alcohol to dehydrate. The possibility of predicting by means of polarisation curves the conditions of occurrence of SCC of titanium has been confirmed by simply analysing when corrosion potential is higher than breakdown potential

  11. ISO 55000: Creating an asset management system.

    Science.gov (United States)

    Bradley, Chris; Main, Kevin

    2015-02-01

    In the October 2014 issue of HEJ, Keith Hamer, group vice-president, Asset Management & Engineering at Sodexo, and marketing director at Asset Wisdom, Kevin Main, argued that the new ISO 55000 standards present facilities managers with an opportunity to create 'a joined-up, whole lifecycle approach' to managing and delivering value from assets. In this article, Kevin Main and Chris Bradley, who runs various asset management projects, examine the process of creating an asset management system.

  12. Plan de implementación de un SGSI acorde a la norma ISO/IEC 27001:2005

    OpenAIRE

    Álvarez Verdugo, Joaquín

    2014-01-01

    Plan de implementación de un SGSI acorde a la norma ISO/IEC 27001:2005 en un organismo público municipal. Pla d'implementació d'un SGSI d'acord amb la norma ISO/IEC 27001:2005 en un organisme públic municipal. Master thesis for the ICT Security management program.

  13. Development of Quality Management System Under ISO 9001:2015 and Joint Inspection Group (JIG for Aviation Fuelling Service

    Directory of Open Access Journals (Sweden)

    Ruamchat Kanon

    2017-09-01

    Full Text Available The Joint Inspection Group (JIG standard for aviation fuel quality management assists in the operational process and maintenance of aviation fuel from its point of origin and through distribution systems to airports. Currently, problems arise as the JIG standard and quality management in aviation fuel are isolated and have independent procedures. Merging the JIG standards with ISO 9001:2015 can override original JIG’s philosophy by connecting all quality assessment, and management parties involved, throughout the supply chain. This integration can harmonize auditing tasks, focusing on risk/opportunity, and continue quality improvement focus. This paper proposes a development of quality management system (QMS under ISO 9001:2015 for aviation fuelling service in a systematic way. The content and critical success factors of ISO 9001:2015 and JIG standards were studied. The beneficial synergies, similarities, and logical linkages between both standards are identified. This QMS was developed in the largest petroleum company in Thailand and 60 selected experts were surveyed, with a response rate of 88.3%, for their agreement on integrated criteria. Two external quality auditors, who have ISO 9001 and JIG expertise, were interviewed to modify our initial proposed QMS. The final QMS was implemented in the into-plane fuelling services as the first phase of this implementation. Results of framework implementation are discussed in a case study. There are mutual benefits resulting from the integration of JIG and ISO 9001:2015 standards. This QMS provides a unified process for quality management practices, and enhances the effectiveness of risk evaluation as well as the opportunity for continued quality improvement. It facilitates the identification of ISO 9001:2015 requirements and establishes relationships between the roles of JIG standard and the clauses of ISO 9001:2015. The first experience from five airports as the pilot study of proposed QMS

  14. Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis.

    Science.gov (United States)

    Miraloglu, Meral; Kurutas, Ergul Belge; Ozturk, Perihan; Arican, Ozer

    2016-01-01

    Tinea pedis (TP) is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. Up to the now, the local 8-iso-prostaglandin F2α (8-iso-PGF2α), concentration as oxidative stress biomarker and trace elements status have not been published in patients with TP. The aim of this study is to evaluate the relationship between oxidative stress and trace elements (Cu, Zn, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder. Forty-three consecutive patients with a diagnosis of unilateral interdigital TP were enrolled in this study. The samples were obtained by scraping the skin surface. 8-iso-PGF2α concentrations in scraping samples were determined by ELISA. In addition, the levels of Se, Zn and Cu in scraping samples were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction. Oxidative stress was confirmed by the significant elevation in 8-iso-PGF2α concentrations (p iso-PGF2α parameters, but negative correlations between Se-Cu; Se-8-iso-PGF2α parameters in lesional area. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher on the lesional area than the non-lesional area (p iso-PGF2α and trace elements in patients with TP (p > 0.05). Our results showed that there is a possible link between oxidative stress (increased 8-iso-PGF2α concentrations) and imbalanced of trace elements status in lesional area of TP patients. The use of antifungal agents together with both Zn and Se drugs could be helpful in the both regression of disease and in shortening the duration of disease.

  15. Implementing the Environmental Management System ISO 14001 at the Cernavoda NPP Unit 1

    International Nuclear Information System (INIS)

    Jelev, Adrian

    2003-01-01

    An environmental management plan (EMP) has been developed for the Cernavoda NPP Unit 1. It contains the necessary components for identification and management of the environmental aspects of NPP. The environmental policy of the 'Nuclearelectrica' National Society and the associated EMP are the basis for the Environment Management System that will be implemented at Cernavoda NPP. The final step of this process will be the ISO 14001 certification. This paper points out to the main aspects concerning the implementation of the ISO 14001 system at Cernavoda NPP Unit 1. (author)

  16. The European large area ISO survey - III. 90-mu m extragalactic source counts

    DEFF Research Database (Denmark)

    Efstathiou, A.; Oliver, S.; Rowan-Robinson, M.

    2000-01-01

    We present results and source counts at 90 mum extracted from the preliminary analysis of the European Large Area ISO Survey (ELAIS). The survey covered about 12 deg(2) of the sky in four main areas and was carried out with the ISOPHOT instrument onboard the Infrared Space Observatory (ISO...... or small groups of galaxies, suggesting that the sample may include a significant fraction of luminous infrared galaxies. The source counts extracted from a reliable subset of the detected sources are in agreement with strongly evolving models of the starburst galaxy population....

  17. Utilidad de los arquetipos ISO 13606 para representar modelos clínicos detallados

    OpenAIRE

    Serrano, Pablo; Moner Cano, David; Sebastian, Tomás; Maldonado Segura, José Alberto; Navalón, Rafael; Robles Viejo, Montserrat; Gómez, Ángel

    2009-01-01

    Objetivo: Evaluar la utilidad de los Arquetipos ISO/CEN 13606 y openEHR en la representación de modelos clínicos detallados. Metodología: como editores de arquetipos se utilizaron LinkERH para ISO/CEN 13606 y los editores de Ocean Informatics y LiU para openEHR. Como caso de uso se representaron los conjuntos de datos identificados en los modelos locales de tres sistemas (hospital, UCI y atención primaria) en el dominio de la úlcera por decúbito, abarcando la observación, evalu...

  18. Would ISO 9000 have prevented the two major radiotherapy accidents in the UK?

    International Nuclear Information System (INIS)

    McKenzie, A.L.

    1997-01-01

    There have been two major accidents in the UK. In Exeter, 207 patients were overdosed by 25%, and, in Stoke-on-Trent, just under 1000 patients were underdoses by about the same amount. The ISO 9000 quality assurance system should create an environment and a culture where the risk of such an accident is minimized. In this presentation, the background to the two accidents is analysed in the light of the question - would these accidents have occurred if ISO 9000 had been in place in the two centres?

  19. Implantación del Sistema de Calidad ISO 9001 en VECOPOL S.L.

    OpenAIRE

    González, Berta

    2012-01-01

    En este trabajo trataré de desarrollar e implantar el Sistema de Calidad ISO 9001 en la empresa VECOPOL S.L. El objetivo que me planteo es desarrollar parte de la documentación del Sistema de Calidad ISO 9001 e iniciar su implantación de forma que se empiece a trabajar en un entorno de calidad, con el propósito fundamental de satisfacer al cliente. En un futuro, si la empresa lo considera conveniente, se podrá certificar el Sistema de Gestión de Calidad.

  20. A comparison of ISO 14001 to other related environmental management systems and tools

    International Nuclear Information System (INIS)

    White, S.E.; Byron, D.F.; Livingston, B.L.

    1995-08-01

    Efficient environmental management is of increasing priority for the industrial sector. The achievement of ISO 14001 certification will demonstrate that the environmental management system meets or exceeds industry standards since this standard will be the accepted international measure of environmental management. A review of published environmental management systems and tools was conducted to ensure all aspects of environmental management are covered in the establishment or formalization of an environmental management system. The objective of this effort is to compare the ISO 14001 standard with other environmental management systems and tools

  1. Elaboración de un plan de implementación de la ISO/IEC 27001:2005 en le empresa Ahorraya

    OpenAIRE

    Castillo Tibaná, Armando Augusto

    2014-01-01

    Implementación de un sistema de gestión de seguridad de la información (SGSI), basado en las normas ISO 27001:2005 e ISO 27002:2005, en la empresa financiera Ahorraya, el cual pretende administrar el modelo de seguridad y gestionar los riesgos presentados en la organización llevándolos a su mínima expresión. Implementació d'un sistema de gestió de seguretat de la informació (SGSI), basat en les normes ISO 27001:2005 i ISO 27002:2005, a l'empresa financera Ahorraya, el qual pretén administr...

  2. Evaluation of ISO CRS Envelopes Relative to U.S. Vehicles and Child Restraint Systems.

    Science.gov (United States)

    Hu, Jingwen; Manary, Miriam A; Klinich, Kathleen D; Reed, Matthew P

    2015-01-01

    The objectives of this study are to use computer simulation to evaluate the International Organization for Standardization (ISO) 13216-3:2006(E) child restraint system (CRS) envelopes relative to rear seat compartments from vehicles and CRSs in the U.S. market, investigate the potential compatibility issues of U.S. vehicles and CRSs, and demonstrate whether necessary modifications can be made to introduce such a system into compatibility evaluations between U.S. vehicles and CRSs. Three-dimensional geometry models for 26 vehicles and 16 convertible CRS designs developed previously were used. Geometry models of 3 forward-facing and 3 rear-facing CRS envelopes provided by the ISO were built in the current study. The virtual fit process closely followed the physical procedures described in the ISO standards. The results showed that the current ISO rear-facing envelopes can provide reasonable classifications for CRSs and vehicles, but the forward-facing envelopes do not represent products currently in the U.S. market. In particular, all of the selected vehicles could accommodate the largest forward-facing CRS envelope at the second-row seat location behind the driver seat. In contrast, half of the selected CRSs could not fit within any of the forward-facing ISO CRS envelopes, mainly due to protrusion at the rear-top corner of the envelope. The results also indicate that the rear seat compartment in U.S. vehicles often cannot accommodate a large portion of convertible CRSs in the rear-facing position. The increased demand for vehicle fuel economy and the recommendation to keep children rear-facing longer may lead to smaller cars and larger CRSs, which may increase the potential for fit problems. The virtual classifications indicated that contact between the forward-facing CRSs and the head restraints in the rear seats as well as that between the rear-facing CRSs and the back of the front seats is a main concern regarding the compatibility between the vehicles and the

  3. Quality assurance and management in microelectronics companies: ISO 9000 versus Six Sigma

    Science.gov (United States)

    Lupan, Razvan; Kobi, Abdessamad; Robledo, Christian; Bacivarov, Ioan; Bacivarov, Angelica

    2009-01-01

    A strategy for the implementation of the Six Sigma method as an improvement solution for the ISO 9000:2000 Quality Standard is proposed. Our approach is focused on integrating the DMAIC cycle of the Six Sigma method with the PDCA process approach, highly recommended by the standard ISO 9000:2000. The Six Sigma steps applied to each part of the PDCA cycle are presented in detail, giving some tools and training examples. Based on this analysis the authors conclude that applying Six Sigma philosophy to the Quality Standard implementation process is the best way to achieve the optimal results in quality progress and therefore in customers satisfaction.

  4. MANAJEMEN RISIKO KEAMANAN SISTEM INFORMASI MENGGUNAKAN METODE FMEA DAN ISO 27001 PADA ORGANISASI XYZ

    Directory of Open Access Journals (Sweden)

    Raden Budiarto

    2017-07-01

    Full Text Available Sekalipun sudah populer di bidang teknik industri, metode Failure Mode & Effect Analysis FMEA masih sangat jarang dilaporkan penelitiannya terhadap objek sistem informasi. Hal ini menarik untuk dieksplorasi lebih lanjut pemanfaatannya pada sistem informasi. Variabel yang diukur pada penelitian ini adalah occurrence (frekuensi kejadian, severity (dampak dan detection (pencegahan. Data penelitian diambil terutama berdasarkan dari hasil pengamatan langsung. Penelitian ini mencakup perlindungan terhadap aset informasi di lingkungan Organisasi XYZ dengan melakukan penilaian risiko keamanan informasi. Penilaian tersebut dilakukan dengan menggunakan metode (FMEA. Pada penelitian ini juga menggunakan kerangka kerja ISO 27001 untuk melengkapi daftar rekomendasi aksi penanggulangan mode kegagalan. Hasil dari penelitian ini yaitu berupa laporan hasil pengelolaan manajemen risiko yang berisikan daftar prioritas analisis risiko yang disertai akar sebab permasalahan dan pengendalian risiko sesuai dengan standar ISO 27001. Hasil dari studi kasus telah membuktikan penerapan standar ISO 27001 berimbas terhadap penurunan tingkat kerawanan sebesar 30%.

  5. 75 FR 18828 - PSEG Power Connecticut LLC, Complainant v. ISO New England Inc., Respondent; Notice of Complaint

    Science.gov (United States)

    2010-04-13

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL10-58-000] PSEG Power Connecticut LLC, Complainant v. ISO New England Inc., Respondent; Notice of Complaint April 6, 2010. Take... ISO New England Inc. (Respondent) challenging the justness and reasonableness of the Respondent's...

  6. DAMPAK PENERAPAN SMM ISO 9001:2000 TERHADAP KUALITAS LAYANAN AKADEMIK DAN LULUSAN FT UNY

    Directory of Open Access Journals (Sweden)

    Sugiyono Sugiyono

    2015-02-01

    Full Text Available ABSTRACT This research aims at revealing the impact of the implimentation of ISO 9001:2000 towards the academic service quality (the service quality of lecturers, staffs, technicians, and department orginizer and the graduates’ quality (GPA and period of study. This evaluation was conducted by using descriptive research method and document analysis to reveal the fact of academic service beforeand after the implementation of ISO 9001:2000. The sample technique was using cluster sampling technique as PTM and PTTB departments were chosen. The target sample was 83 students in the seventh semestser and the dacuments in ISO secretariat from those two deperatments. Data collection techniques were using questionnaire and documentation (syallabus and lesson plan, yusisum data, learning evaluation, attandence list and assessement document. Data analysis method was using quatitive descriptive analysis. The findings showed the mean scores of acedemic sevice quality in PTBB Department had been fulfilling the expectation (3,12 while for PTM can be categorized as moderate level (2.97. The lowest score was found in the area of academic administration service, i.e. 3,02 for PTBB and 2,83 for PTM. Furthermore, it was found that The quality of PTBB graduates improved 0,02 and the period of study for (S1/ Bachelor degree fluctuated in 5,16 while the GPA of PTM was not stable yet but the students had shorter period of study. By seeing the findings, it can concluded that the implementation of ISO 9001-2000 was able to improve the administration service of academic but it did not guarantee to create qualified acadmic service to support the fulfilment of high GPA and short period of study. Keywords: graduates’ quality, SMM-ISO 9001-2000, quality of academic service

  7. ISO 15189 accreditation: Requirements for quality and competence of medical laboratories, experience of a laboratory I.

    Science.gov (United States)

    Guzel, Omer; Guner, Ebru Ilhan

    2009-03-01

    Medical laboratories are the key partners in patient safety. Laboratory results influence 70% of medical diagnoses. Quality of laboratory service is the major factor which directly affects the quality of health care. The clinical laboratory as a whole has to provide the best patient care promoting excellence. International Standard ISO 15189, based upon ISO 17025 and ISO 9001 standards, provides requirements for competence and quality of medical laboratories. Accredited medical laboratories enhance credibility and competency of their testing services. Our group of laboratories, one of the leading institutions in the area, had previous experience with ISO 9001 and ISO 17025 Accreditation at non-medical sections. We started to prepared for ISO 15189 Accreditation at the beginning of 2006 and were certified in March, 2007. We spent more than a year to prepare for accreditation. Accreditation scopes of our laboratory were as follows: clinical chemistry, hematology, immunology, allergology, microbiology, parasitology, molecular biology of infection serology and transfusion medicine. The total number of accredited tests is 531. We participate in five different PT programs. Inter Laboratory Comparison (ILC) protocols are performed with reputable laboratories. 82 different PT Program modules, 277 cycles per year for 451 tests and 72 ILC program organizations for remaining tests have been performed. Our laboratory also organizes a PT program for flow cytometry. 22 laboratories participate in this program, 2 cycles per year. Our laboratory has had its own custom made WEB based LIS system since 2001. We serve more than 500 customers on a real time basis. Our quality management system is also documented and processed electronically, Document Management System (DMS), via our intranet. Preparatory phase for accreditation, data management, external quality control programs, personnel related issues before, during and after accreditation process are presented. Every laboratory has

  8. Transforming an EPA QA/R-2 quality management plan into an ISO 9002 quality management system.

    Science.gov (United States)

    Kell, R A; Hedin, C M; Kassakhian, G H; Reynolds, E S

    2001-01-01

    The Environmental Protection Agency's (EPA) Office of Emergency and Remedial Response (OERR) requires environmental data of known quality to support Superfund hazardous waste site projects. The Quality Assurance Technical Support (QATS) Program is operated by Shaw Environmental and Infrastructure, Inc. to provide EPA's Analytical Operations Center (AOC) with performance evaluation samples, reference materials, on-site laboratory auditing capabilities, data audits (including electronic media data audits), methods development, and other support services. The new QATS contract awarded in November 2000 required that the QATS Program become ISO 9000 certified. In a first for an EPA contractor, the QATS staff and management successfully transformed EPA's QA/R-2 type Quality Management Plan into a Quality Management System (QMS) that complies with the requirements of the internationally recognized ISO 9002 standard and achieved certification in the United States, Canada, and throughout Europe. The presentation describes how quality system elements of ISO 9002 were implemented on an already existing quality system. The psychological and organizational challenges of the culture change in QATS' day-to-day operations will be discussed for the benefit of other ISO 9000 aspirants.

  9. Design of an Electronic Healthcare Record Server Based on Part 1 of ISO EN 13606

    Directory of Open Access Journals (Sweden)

    Tony Austin

    2011-01-01

    Full Text Available ISO EN 13606 is a newly approved standard at European and ISO levels for the meaningful exchange of clinical information between systems. Although conceived as an inter-operability standard to which existing electronic health record (EHR systems will transform legacy data, the requirements met and architectural approach reflected in this standard also make it a good candidate for the internal architecture of an EHR server. The authors have built such a server for the storage of healthcare records and demonstrated that it is possible to use ISO EN 13606 part 1 as the basis of an internal system architecture. The development of the system and some of the applications of the server are described in this paper. It is the first known operational implementation of the standard as an EHR system.

  10. Updated API document 6A will close API-ISO 9000 gap. [Oil and gas wellhead standards

    Energy Technology Data Exchange (ETDEWEB)

    Bell, S.

    1993-10-01

    The 17th edition of the American Petroleum Institute's (API) document 6A, covering wellheads and their components, is due early next year. As the API vs. International Standards Organization (ISO) 9000 struggle continues, this edition of 6A eliminates some unnecessary specifications, clarifies others, and includes metric specifications accepted by the ISO. The 17th edition will clarify some of the interpretations from earlier editions and further advise users how to acquire the API monogram. The goal of this edition is to make 6A acceptable to ISO as an international document so API can maintain control over petroleum equipment specifications and provide input and guidance in future regulations.

  11. The current status of radiopharmacy laboratories in Turkey, conveniences to good radiopharmacy practice (GRP) and quality management systems (ISO)

    International Nuclear Information System (INIS)

    Atak, I.E.

    2004-01-01

    This study ha been conducted in the Radiopharmacy Laboratories of Nuclear Medicine departments of various hospitals and private nuclear medicine laboratories. A total of 35 laboratories from 7 regions of Turkey have been selected by layered sampling method from 131 Radiopharmacy Laboratories located in 30 different cities. During the study, a GRP investigation list with 67 questions and direct communication technique have been used. The aim was determine the current status of the Radiopharmacy Laboratories in general and the administration of radiopharmaceuticals on patients, and good practices in radiopharmacy and conformance with quality assurance systems. In this respect, questions have been asked to determine a) General status, b) Information level of lab workers regarding to the GRP and ISO concepts (i-Status of lab managers, ii- Responsibilities and knowledge of lab workers and iii- regarding to GRP and ISO-9000), c) Conditions of infrastructure, and lab services and its quality, d) Status of organizations. Results showed that only two of the 35 managers of laboratories were radiopharmacists, the rest were Nuclear Medicine specialists. There were less knowledge on GRP than ISO, the labs holding ISO certificate were in minority even though ISO is known concept, radiopharmacist were more knowledgeable in GRP while nuclear medicine specialists were in ISO, the labs with better GRP knowledge have better infrastructure, the GRP knowledge were better in the university and armed forces hospitals while ISO knowledge and certificates were more in private labs and hospitals, the armed forces hospitals better paraphernalia, practically almost all radiopharmaceutical kits were imported goods and there were important problems in quality control

  12. 78 FR 1851 - New England States Committee on Electricity v. ISO New England Inc.; Notice of Complaint

    Science.gov (United States)

    2013-01-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL13-34-000] New England States Committee on Electricity v. ISO New England Inc.; Notice of Complaint Take notice that on December... (Complainant) filed a formal complaint against ISO New England Inc. (Respondent) alleging that the Respondent's...

  13. Verification of the ISO calibration method for field pyranometers under tropical sky conditions

    Science.gov (United States)

    Janjai, Serm; Tohsing, Korntip; Pattarapanitchai, Somjet; Detkhon, Pasakorn

    2017-02-01

    Field pyranomters need to be annually calibrated and the International Organization for Standardization (ISO) has defined a standard method (ISO 9847) for calibrating these pyranometers. According to this standard method for outdoor calibration, the field pyranometers have to be compared to a reference pyranometer for the period of 2 to 14 days, depending on sky conditions. In this work, the ISO 9847 standard method was verified under tropical sky conditions. To verify the standard method, calibration of field pyranometers was conducted at a tropical site located in Nakhon Pathom (13.82o N, 100.04o E), Thailand under various sky conditions. The conditions of the sky were monitored by using a sky camera. The calibration results for different time periods used for the calibration under various sky conditions were analyzed. It was found that the calibration periods given by this standard method could be reduced without significant change in the final calibration result. In addition, recommendation and discussion on the use of this standard method in the tropics were also presented.

  14. Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery.

    Science.gov (United States)

    Zheng, Yuan-Bo; Ruan, Guo-Mo; Fu, Jia-Xing; Su, Zhong-Liang; Cheng, Peng; Lu, Jian-Zuo

    2016-04-01

    Oxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present study aimed to investigate the ability of postoperative plasma 8-iso-PGF2α levels to predict POD and POCD in elderly patients undergoing hip fracture surgery. Postoperative plasma 8-iso-PGF2α levels of 182 patients were measured by an enzyme-linked immunosorbent assay. We assessed the relationships between plasma 8-iso-PGF2α levels and the risk of POD and POCD using a multivariate analysis. Plasma 8-iso-PGF2α levels and age were identified as the independent predictors for POD and POCD. Based on areas under receiver operating characteristic curve, the predictive values of 8-iso-PGF2α were obviously higher than those of age for POD and POCD. In a combined logistic-regression model, 8-iso-PGF2α significantly enhanced the areas under curve of age for prediction of POD and POCD. Postoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. REASONS FOR TECHNOLOGY-BASED COMPANIES CONTEMPLATED BY THE FIRST COMPANY PROGRAM TO SEEK ISO 9001:2008 CERTIFICATION

    Directory of Open Access Journals (Sweden)

    Eduardo Gomes Salgado

    2016-03-01

    Full Text Available The search for implementation of Quality Management Systems aims to continuously improve their results. Thus, for the services and/or products offered to convey trust and credibility, they must be designed within appropriate norms and standards. In this sense, this study seeks to assess the reasons that induce incubated technology-based companies to seek adequacy of their quality management system to the NBR ISO 9001:2008 standard. Through an exploratory survey in twenty-six incubated technology-based companies, a twelve-question questionnaire proposed by Bhuiyan and Alam (2005 was applied. After analyzing the data, it is concluded that the reasons for adequacy of QMS to the NBR ISO 9001:2008 standard are: competitive advantage over competitors; consultant´s approach for implementation; improvement in product quality; and government funding for ISO 9001 certification.  It is found that the consultant´s approach stands out as a strong reason for seeking the adequacy of QMS to the NBR ISO 9001 standard.

  16. THE TRANSITIONAL CHANGE ON THE IMPLEMENTATION OF ISO 14001:2015 IN COPPER ORE MILL – CASE STUDY

    Directory of Open Access Journals (Sweden)

    Arif Susanto

    2017-09-01

    Full Text Available The transition process of implementation standard for environmental management system (EMS ISO 14001 :2015 lasts for three years, requiring every organization to adopt the latest version by September 2018. The objectives of this research is to describe and analyze the stages done by copper ore mill. This research used concept analysis method, which focused and could be basically defined to examine the basic elements of widely used concept to clarify ISO 14001 :2015 standards characteristics and relations. The result of this research provided a conceptual framework based on the standard of ISO 14001:2015 – EMS : Requirements with Guidance for Use, where this framework consists to steps to design the transition change from EMS ISO 14001 :2004 to its 2015 new version. The description of every step is expected to give understanding and model for organizations that must conduct transition and for the ones that will start implementing the EMS.

  17. Aplicació de normes ISO 9001:2000

    OpenAIRE

    Etminani Moslehi-Tehrani, Houman

    2009-01-01

    Este documento se trata de la implantacion y aplicacion de la norma UNE-EN-ISO 9001:2000 a partir de la politica de la empresa LBS respecto a la calidad, proporcionando elementos para lograr la calidad de los productos y servicios de acuerdo con los requisitos y necesidades del cliente, con el compromiso de asegurar y garantizar permanentemente la calidad de dichos productos y servicios consiguiendo la satisfaccion del cliente. Esta norma define un sistema de gestion de la cali...

  18. An iso-α-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice.

    Science.gov (United States)

    Hege, Marianne; Jung, Finn; Sellmann, Cathrin; Jin, Chengjun; Ziegenhardt, Doreen; Hellerbrand, Claus; Bergheim, Ina

    2018-01-01

    Results of in vitro and in vivo studies suggest that consumption of beer is less harmful for the liver than consumption of spirits. It also has been suggested that secondary plant compounds derived from hops such as xanthohumol or iso-α-acids may have beneficial effects on the development of liver diseases of various etiologies. The aim of this study was to determine whether iso-α-acids consumed in doses achieved by "normal" beer consumption have beneficial effects on health. Female C57 Bl/6 J mice, pretreated for 4 d with an iso-α-acid-rich extract (∼30% iso-α-acids from hops, 0.75 mg/kg body weight), were fed one bolus of ethanol (6 g/kg body weight intragastric) or an iso-caloric maltodextrin solution. Markers of liver damage, toll-like receptor-4 signaling, and lipid peroxidation were determined. Furthermore, the effect of isohumulone on the lipopolysaccharide-dependent activation of J774 A.1 macrophages, used as a model of Kupffer cells, was determined. In the liver, acute ethanol administration led to a significant accumulation of fat (∼10-fold), which was accompanied by significantly higher inducible nitric oxide synthase protein level, elevated nitric oxide production, and increased plasminogen activator inhibitor 1 protein concentration when compared to controls. In mice pretreated with iso-α-acids, these effects of alcohol were markedly attenuated. Pretreatment of J774 A.1 macrophages with isohumulone significantly attenuated lipopolysaccharide-induced mRNA expression of inducible nitric oxide synthase and interleukin-6 as well as the release of nitric oxide. Taken together, iso-α-acids markedly attenuated the development of acute alcohol-induced damage in mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. EXPLORING THE POTENTIAL OF INTEGRATION QUALITY ASSESSMENT SYSTEM IN CONSTRUCTION (QLASSIC WITH ISO 9001 QUALITY MANAGEMENT SYSTEM (QMS

    Directory of Open Access Journals (Sweden)

    Mukhtar Che Ali

    2014-03-01

    Full Text Available Quality has been identified as one of the fundamental needs of clients. As such construction projects that are able to be completed with distinctive quality will definitely enable to delight their customers. In this regard, Construction Industry Development Board (CIDB has introduced two quality related programs namely ISO 9001 DIY Scheme and QLASSIC. The later is essentially a quality performance assessment tool to evaluate the level of quality of a building construction work based on quality standards stipulated in CIS 7:2006. One of the key deliverables of QLASSIC is QLASSIC Score which denotes the level of quality of the assessed construction project. Potentially there is a strong correlation between QLASSIC and ISO 9001 QMS. However there is lack of knowledge in the industry in am algamating QLASSIC with ISO 9001QMS towards attaining high quality performance. Indeed it is noticed that not many studies have been undertaken in this area. Thus it warrants to undertake a study that deliberates on the relationship of practicing ISO 9001Q MS with the achievement of QLASSIC Score. Therefore among the key objectives of this research are generally to investigate the relationship between practicing ISO 9001 QMS principles with QLASSIC performance and to examine the expected business outcomes for ISO 9001 certified contractors that are able to sustain relatively high QLASSIC Score. Eventually it is postulated that the output of this research would enable to elevate the level of quality performance in the Malaysian construction industry.

  20. Malaysian qualification and certification scheme for NDT personnel: achievements and steps toward harmonization in accordance with ISO 9712

    International Nuclear Information System (INIS)

    Abd Nassir Ibrahim

    2001-01-01

    Development of skilled manpower in the field of NDT is one the most important component that must be given priority in order to ensure the sustainability of the technology in any country. In this respect ISO 9712 provides a guideline on the implementation of HRD program in the field of NDT that involved training, qualification and certification processes. ISO 9712 was developed with the hope that it provided a guideline for the establishment of qualification and certification scheme acceptable to the whole NDT community throughout the world. With this guideline, the process of qualification and certification of NDT personnel of different countries throughout the world will be harmonized. In Malaysia, such a scheme was established in 1985 with the National Vocational Training Council was appointed as the Certification Body. Although the scheme was developed based on ISO 97121 some local requirement were included which made the scheme somewhat deviated from the ISO practices. Twenty years after it was first implemented, the scheme was revised and amended to ensure that requirements of ISO 9712 are complied. The new scheme was revised and approved in April 2000 and was implemented for the first time in November radiography level 1 examination. (Author)

  1. [Quality assurance in student training. Prerequisites for DIN EN ISO 9001:2000 in teaching].

    Science.gov (United States)

    Ochsner, W; Kaiser, C; Schirmer, U

    2007-07-01

    Standards of quality assurance according to DIN EN ISO 9001:2000 have been implemented in many university hospital departments, but often teaching activities are not included. This work presents a method that allows, after having defined the various teaching activities as sub-processes of one single core process, to include the manifold teaching activities of university hospital departments into the certification process. The stepwise description of the prerequisites for including teaching activities into ISO 9001 certification is illustrated by a concrete implementation example.

  2. Comparison of Hospital standards with ISO principles and presentation appropriate model of Hospital standard development

    Directory of Open Access Journals (Sweden)

    bahram Delgoshai

    2005-02-01

    Conclusion: Writing method of evaluation items in »B hand out« has significant difference with what is done in ISO audit. Research findings showed that in spite of leaping that »B hand out« developing had in national. There are serious lacks in hospital compelete evaluaton so that consider a hospitals system, means and content beacause of lack of enough experiment in standard development based on ISO principles.

  3. First Results of ISO-SWS Grating Observations of Jupiter

    NARCIS (Netherlands)

    Encrenaz, Th.; de Graauw, Th.; Schaeidt, S.; Lellouch, E.; Feuchtgruber, H.; Beintema, D. A.; Bezard, B.; Drossart, P.; Griffin, M.; Heras, A.; Kessler, M.; Leech, K.; Morris, A.; Roelfsema, P. R.; Roos-Serote, M.; Salama, A.; Vandenbussche, B.; Valentijn, E. A.; Davies, G. R.; Naylor, D. A.

    1996-01-01

    The spectrum of Jupiter has been recorded on April 12, 1996, between 2.75 and 14.5 mu m, with the grating mode of the Short-Wavelength Spectrometer of ISO (Infrared Space Observatory). The resolving power is 1500 and the sensitivity limit is better than 1 Jy. The corresponding S/N ratio is better

  4. Transgenic Brassica rapa plants over-expressing eIF(iso)4E variants show broad-spectrum Turnip mosaic virus (TuMV) resistance.

    Science.gov (United States)

    Kim, Jinhee; Kang, Won-Hee; Hwang, Jeena; Yang, Hee-Bum; Dosun, Kim; Oh, Chang-Sik; Kang, Byoung-Cheorl

    2014-08-01

    The protein-protein interaction between VPg (viral protein genome-linked) of potyviruses and eIF4E (eukaryotic initiation factor 4E) or eIF(iso)4E of their host plants is a critical step in determining viral virulence. In this study, we evaluated the approach of engineering broad-spectrum resistance in Chinese cabbage (Brassica rapa) to Turnip mosaic virus (TuMV), which is one of the most important potyviruses, by a systematic knowledge-based approach to interrupt the interaction between TuMV VPg and B. rapa eIF(iso)4E. The seven amino acids in the cap-binding pocket of eIF(iso)4E were selected on the basis of other previous results and comparison of protein models of cap-binding pockets, and mutated. Yeast two-hybrid assay and co-immunoprecipitation analysis demonstrated that W95L, K150L and W95L/K150E amino acid mutations of B. rapa eIF(iso)4E interrupted its interaction with TuMV VPg. All eIF(iso)4E mutants were able to complement an eIF4E-knockout yeast strain, indicating that the mutated eIF(iso)4E proteins retained their function as a translational initiation factor. To determine whether these mutations could confer resistance, eIF(iso)4E W95L, W95L/K150E and eIF(iso)4E wild-type were over-expressed in a susceptible Chinese cabbage cultivar. Evaluation of the TuMV resistance of T1 and T2 transformants demonstrated that the over-expression of the eIF(iso)4E mutant forms can confer resistance to multiple TuMV strains. These data demonstrate the utility of knowledge-based approaches for the engineering of broad-spectrum resistance in Chinese cabbage. © 2014 BSPP AND JOHN WILEY & SONS LTD.

  5. The assurance as a result of blood chemical analysis by ISO-GUM and QE

    Energy Technology Data Exchange (ETDEWEB)

    Iwaki, Y., E-mail: yasuo.iwaki@nifty.ne.j

    2010-07-01

    The Quality Assurance (QA) of measurand has been discussed over many years by Quality Engineering (QE). It is need to more discuss about ISO standard. It is mining to find out root fault element for improvement of measured accuracy, and it remove. The accuracy assurance needs to investigate the Reference Material (RM) for calibration and an improvement accuracy of data processing. This research follows the accuracy improvement in field of data processing by how to improve of accuracy. As for the fault element relevant to measurement accuracy, in many cases, two or more element is buried exist. The QE is to assume the generating frequency of fault state, and it is solving from higher ranks for fault factor first by 'Failure Mode and Effects Analysis' (FMEA). Then QE investigate the root cause over the fault element by 'Root Cause Analysis (RCA)' and 'Fault Tree Analysis (FTA)' and calculate order to the generating element of assume specific fault. These days comes, the accuracy assurance of measurement result became duty in the Professional Test (PT). ISO standard was legislated by ISO-GUM (Guide of express Uncertainty in Measurement) as guidance of an accuracy assurance in 1993 [1] for QA. Analysis method of ISO-GUM is changed into Exploratory Data Analysis (EDA) from Analysis of Valiance (ANOVA). EDA calculate one by one until an assurance performance is obtained according to 'Law of the propagation of uncertainty'. If the truth value was unknown, ISO-GUM is changed into reference value. A reference value set up by the EDA and it does check with a Key Comparison (KC) method. KC is comparing between null hypothesis and frequency hypothesis. It performs operation of assurance by ISO-GUM in order of standard uncertainty, the combined uncertainty of many fault elements and an expansion uncertain for assurance. An assurance value is authorized by multiplying the final expansion uncertainty [2] by K of coverage factor. K-value is

  6. Nonparametric decision tree: The impact of ISO 9000 on certified and non certified companies Nonparametric decision tree: The impact of ISO 9000 on certified and non certified companies Nonparametric decision tree: The impact of ISO 9000 on certified and non certified companies

    Directory of Open Access Journals (Sweden)

    Joaquín Texeira Quirós

    2013-09-01

    Full Text Available Purpose: This empirical study analyzes a questionnaire answered by a sample of ISO 9000 certified companies and a control sample of companies which have not been certified, using a multivariate predictive model. With this approach, we assess which quality practices are associated to the likelihood of the firm being certified. Design/methodology/approach: We implemented nonparametric decision trees, in order to see which variables influence more the fact that the company be certified or not, i.e., the motivations that lead companies to make sure. Findings: The results show that only four questionnaire items are sufficient to predict if a firm is certified or not. It is shown that companies in which the respondent manifests greater concern with respect to customers relations; motivations of the employees and strategic planning have higher likelihood of being certified. Research implications: the reader should note that this study is based on data from a single country and, of course, these results capture many idiosyncrasies if its economic and corporate environment. It would be of interest to understand if this type of analysis reveals some regularities across different countries. Practical implications: companies should look for a set of practices congruent with total quality management and ISO 9000 certified. Originality/value: This study contributes to the literature on the internal motivation of companies to achieve certification under the ISO 9000 standard, by performing a comparative analysis of questionnaires answered by a sample of certified companies and a control sample of companies which have not been certified. In particular, we assess how the manager’s perception on the intensity in which quality practices are deployed in their firms is associated to the likelihood of the firm being certified.Purpose: This empirical study analyzes a questionnaire answered by a sample of ISO 9000 certified companies and a control sample of companies

  7. Covenants with Weak Swords: ISO 14001 and Facilities' Environmental Performance

    Science.gov (United States)

    Potoski, Matthew; Prakash, Aseem

    2005-01-01

    Voluntary environmental programs are codes of progressive environmental conduct that firms pledge to adopt. This paper investigates whether ISO 14001, a voluntary program with a weak sword--a weak monitoring and sanctioning mechanism--can mitigate shirking and improve participants' environmental performance. Sponsored by the International…

  8. Information Asymmetries as Trade Barriers: ISO 9000 Increases International Commerce

    Science.gov (United States)

    Potoski, Matthew; Prakash, Aseem

    2009-01-01

    Spatial, cultural, and linguistic barriers create information asymmetries between buyers and sellers that impede international trade. The International Organization for Standardization's ISO 9000 program is designed to reduce these information asymmetries by providing assurance about the product quality of firms that receive its certification.…

  9. Implementation of the ISO 9001 quality management system - process, impact and benefits

    Directory of Open Access Journals (Sweden)

    Aleksandar Ž. Drenovac

    2013-10-01

    Full Text Available Modern business is characterized by greater and greater market competition through all business areas and all activities. Establishment of market positions is a very important element of business activities in every organization. Quality of products and/or services provides recognizability at market and raising of ratings. Implementation of the ISO 9001 quality management system opens positions for secure national and international markets; it is also an identifier of an efficiently and effectively process-wise organized system in an organization. Introduction An increase of impact of quality and demands for ensuring quality before contract approvals has been visible lately. All vendors at the multinational market must ensure confidence in the quality of their products or services in order to satisfy customer demands which is an ultimate goal. Organizations which have the certificated ISO 9001 standard are known for their persistence and reliability, so they reach high reputation by applying  the standard. Implementation of a quality management system Implementation of a quality management system is done by system engineering, as a process based on a top management decision. It can be applied through the engagement of professionals from within the organization, as well as through outsourced consultants. The process is based on the PDCA cycle and the eight principles of quality management in an ISO 9001 organization. Defining assignments in accordance with the standard The Quality Manual, as a document which contains quality aims and through which a complete model of the quality management system is described, should be an initial element for the process of implementing a quality management system. It contains an overview of all procedures and directions used for achieving quality policy, i.e. for the implementation of a quality management system in every part of a business system. Implementation of procedures When the Quality manual is created

  10. The thermal degradation of poly(iso-butyl methacrylate and poly(sec-butyl methacrylate

    Directory of Open Access Journals (Sweden)

    IVANKA G. POPOVIC

    2000-12-01

    Full Text Available The non-oxidative thermal degradation of poly(iso-butyl methacrylate and poly(sec-butyl methacrylate was investigated by studying changes in the polymer residue. Due to the different number of b-hydrogens in their ester substituents, these two polymeric isomers behave differently when subjected to elevated temperatures. Poly(iso-butyl methacrylate degrades quantitatively by depolymerisation with zip lengths of the same order of magnitude as those of poly(methyl methacrylate. Poly(sec-butyl methacrylate degrades by a combined degradation mechanism of depolymerisation and de-esterification. De-esterification becomes a significant thermolysis route at temperatures higher than 240°C.

  11. IsoDesign: a software for optimizing the design of 13C-metabolic flux analysis experiments.

    Science.gov (United States)

    Millard, Pierre; Sokol, Serguei; Letisse, Fabien; Portais, Jean-Charles

    2014-01-01

    The growing demand for (13) C-metabolic flux analysis ((13) C-MFA) in the field of metabolic engineering and systems biology is driving the need to rationalize expensive and time-consuming (13) C-labeling experiments. Experimental design is a key step in improving both the number of fluxes that can be calculated from a set of isotopic data and the precision of flux values. We present IsoDesign, a software that enables these parameters to be maximized by optimizing the isotopic composition of the label input. It can be applied to (13) C-MFA investigations using a broad panel of analytical tools (MS, MS/MS, (1) H NMR, (13) C NMR, etc.) individually or in combination. It includes a visualization module to intuitively select the optimal label input depending on the biological question to be addressed. Applications of IsoDesign are described, with an example of the entire (13) C-MFA workflow from the experimental design to the flux map including important practical considerations. IsoDesign makes the experimental design of (13) C-MFA experiments more accessible to a wider biological community. IsoDesign is distributed under an open source license at http://metasys.insa-toulouse.fr/software/isodes/ © 2013 Wiley Periodicals, Inc.

  12. Urinary 8-iso-prostaglandin F2α as a marker of metabolic risks in the general Japanese population: The ROAD study.

    Science.gov (United States)

    Mure, Kanae; Yoshimura, Noriko; Hashimoto, Marowa; Muraki, Shigeyuki; Oka, Hiroyuki; Tanaka, Sakae; Kawaguchi, Hiroshi; Nakamura, Kozo; Akune, Toru; Takeshita, Tatsuya

    2015-07-01

    To determine whether 8-iso-prostaglandin F2α (8-iso-PGF2α) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. This was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2α levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis. 8-iso-PGF2α was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2α level in participants aged ≤50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2α level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged ≥71 years, 8-iso-PGF2α was significantly associated with a greater number of MetS risks with higher IGT cut-offs. Urinary 8-iso-PGF2α can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people. © 2015 The Obesity Society.

  13. Characterization of a two-component thermoluminescent albedo dosemeter according to ISO 21909

    Energy Technology Data Exchange (ETDEWEB)

    Martins, M.M., E-mail: marcelo@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN), Av. Salvador Allende s/n, CEP 22780-160, Rio de Janeiro, RJ (Brazil); Mauricio, C.L.P., E-mail: claudia@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN), Av. Salvador Allende s/n, CEP 22780-160, Rio de Janeiro, RJ (Brazil); Pereira, W.W., E-mail: walsan@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN), Av. Salvador Allende s/n, CEP 22780-160, Rio de Janeiro, RJ (Brazil); Silva, A.X. da, E-mail: ademir@con.ufrj.b [Coordenacao dos Programas de Pos-Graduacao em Engenharia, COPPE/PEN Caixa Postal 68509, CEP 21941-972, Rio de Janeiro, RJ (Brazil)

    2011-05-15

    A two-component thermoluminescent albedo neutron monitoring system was developed at Instituto de Radioprotecao e Dosimetria, Brazil. As there is no Brazilian regulation for neutron individual monitoring service, the system was tested according to the ISO 21909 standard. This standard provides performance and test requirements for determining the acceptability of personal neutron dosemeters to be used for the measurement of personal dose equivalent, H{sub p}(10), in neutron fields with energies ranging from thermal to 20 MeV. Up to 40 dosemeters were used in order to accomplish satisfactorily the requirements of some tests. Despite operational difficulties, this albedo system passed all ISO 21909 performance requirements. The results and problems throughout this characterization are discussed in this paper.

  14. IsoDAR@KamLAND: A Conceptual Design Report for the Technical Facility

    CERN Document Server

    Abs, M; Alonso, J R; Axani, S; Barletta, W A; Barlow, R; Bartoszek, L; Bungau, A; Calabretta, L; Calanna, A; Campo, D; Castro, G; Celona, L; Collin, G H; Conrad, J M; Gammino, S; Johnson, R; Karagiorgi, G; Kayser, S; Kleeven, W; Kolano, A; Labrecque, F; Loinaz, W A; Minervini, J; Moulai, M H; Okuno, H; Owen, H; Papavassiliou, V; Shaevitz, M H; Shimizu, I; Shokair, T M; Sorensen, K F; Spitz, J; Toups, M; Vagins, M; Van Bibber, K; Wascko, M O; Winklehner, D; Winslow, L A; Yang, J J

    2015-01-01

    This conceptual design report describes the technical facility for the IsoDAR electron-antineutrino source at KamLAND. The IsoDAR source will allow an impressive program of neutrino oscillation and electroweak physics to be performed at KamLAND. This report provides information on the physics case, the conceptual design for the subsystems, alternative designs considered, specifics of installation at KamLAND, and identified needs for future development. We discuss the risks we have identified and our approach to mitigating those risks with this design. A substantial portion of the conceptual design is based on three years of experimental efforts and on industry experience. This report also includes information on the conventional facilities.

  15. Development of tire road noise chassis-dynamometer simulator. Effect of ISO surface replica model pad on tire road noise; Shisakushita tire romen soon shiken`yo jissha daijo simulator ni tsuite. ISO romen mogi pad wo sochakushita koka ni kansuru kisoteki kento

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, T; Murakami, T; Ogata, S; Sakamoto, I [Traffic Safety and Nuisance Research Inst., Tokyo (Japan)

    1997-10-01

    As a new test facility to clarify noise reduction method of tire road noise, Tire Road Noise Chassis-Dynamometer Simulator was developed. ISO surface replica pads made by copying the texture of ISO surface were attached on the roller surface of this system to simulate tire road noise. This paper described the specifications and characteristics of this system, and the effects of ISO surface replica pads on tire noise measurement by comparing the sound intensity in horizontal plane of tire noise measured in this system with that measured in a single drum tester with safety walk surface. 4 refs., 10 figs., 1 tab.

  16. The process of implementing an ISO 9001 quality management system in a school of nursing.

    Science.gov (United States)

    Lett, M

    2000-01-01

    This paper documents the process undertaken during the establishment of an ISO 9000 series quality management system by a School of Nursing. Further discussion centres around the reasons why an ISO quality management system was implemented, the lessons learnt during the process and the benefits that accreditation has brought to the School of Nursing. The lessons learnt during the process could be of help to other organisations wishing to achieve a similar accreditation status.

  17. Translation initiation factor AteIF(iso4E is involved in selective mRNA translation in Arabidopsis thaliana seedlings.

    Directory of Open Access Journals (Sweden)

    Ana Valeria Martínez-Silva

    Full Text Available One of the most regulated steps of translation initiation is the recruitment of mRNA by the translation machinery. In eukaryotes, this step is mediated by the 5'end cap-binding factor eIF4E bound to the bridge protein eIF4G and forming the eIF4F complex. In plants, different isoforms of eIF4E and eIF4G form the antigenically distinct eIF4F and eIF(iso4F complexes proposed to mediate selective translation. Using a microarray analysis of polyribosome- and non-polyribosome-purified mRNAs from 15 day-old Arabidopsis thaliana wild type [WT] and eIF(iso4E knockout mutant [(iso4E-1] seedlings we found 79 transcripts shifted from polyribosomes toward non-polyribosomes, and 47 mRNAs with the opposite behavior in the knockout mutant. The translationally decreased mRNAs were overrepresented in root-preferentially expressed genes and proteins from the endomembrane system, including several transporters such as the phosphate transporter PHOSPHATE1 (PHO1, Sucrose transporter 3 (SUC3, ABC transporter-like with ATPase activity (MRP11 and five electron transporters, as well as signal transduction-, protein modification- and transcription-related proteins. Under normal growth conditions, eIF(iso4E expression under the constitutive promoter 35 S enhanced the polyribosomal recruitment of PHO1 supporting its translational preference for eIF(iso4E. Furthermore, under phosphate deficiency, the PHO1 protein increased in the eIF(iso4E overexpressing plants and decreased in the knockout mutant as compared to wild type. In addition, the knockout mutant had larger root, whereas the 35 S directed expression of eIF(iso4E caused shorter root under normal growth conditions, but not under phosphate deficiency. These results indicate that selective translation mediated by eIF(iso4E is relevant for Arabidopsis root development under normal growth conditions.

  18. 6-Iso-chlortetracycline or keto form of chlortetracycline? Need for clarification for relevant monitoring of chlortetracycline residues in food.

    Science.gov (United States)

    Gaugain, Murielle; Gautier, Sophie; Bourcier, Sophie; Jacques, Anne-Marie; Laurentie, Michel; Abjean, Jean-Pierre; Hurtaud-Pessel, Dominique; Verdon, Eric

    2015-01-01

    Chlortetracycline (CTC) is a broad-spectrum antibiotic used in veterinary medicine for pulmonary or digestive infections and having a regulatory maximum residue limit (MRL) necessitating an official analytical control method. The purpose of this study was to clarify the identification of different forms of CTC observed in standard solution, in spiked muscle samples and in naturally incurred muscle samples of pigs analysed by LC-MS/MS and to demonstrate the in vivo formation of 6-iso-chlortetracycline and 4-epi-6-iso-CTC as a metabolite of CTC and 4-epi-CTC in muscle. The six following forms were identified, all being isobaric with a protonated molecule at m/z 479 (precursor ion): the keto-enol forms of CTC and the keto-enol forms of 4-epi-chlortetracycline (4-epi-CTC), 6-iso-chlortetracycline (6-iso-CTC) and 4-epi-6-iso-chlortetracycline (4-epi-6-iso-CTC). The 6-iso-CTC and 4-epi-6-iso-CTC were observed only in incurred pig samples so were identified for the first time as metabolites of CTC and 4-epi-CTC. Identification of the different forms was obtained by comparing incurred muscle samples with standard solutions and with spiked samples. Then the differences between the features of the chromatograms obtained by LC-TQ-MS and the fragmentation study of the different forms of CTC obtained by LC-Q-TOF-MS helped us to support this identification. The extraction steps and the LC-MS/MS conditions developed to analyse muscle tissue samples are described. This clarification concerning the rigorous identification of chromatographic peaks allowed us to evaluate the relevance of our monitoring method with regard to the regulations in place in the European Union and could be of help to laboratories involved in official control of antibiotic residues in food of animal origin. Additional results are also presented highlighting the transformation of the CTC when prepared in a mixture with other antibiotics.

  19. Conversion of n-Butane to iso-Butene on Gallium/HZSM-5 Catalysts

    Directory of Open Access Journals (Sweden)

    S.M. Gheno

    2002-07-01

    Full Text Available The conversion of n-butane to iso-butene on gallium/HZSM-5 catalysts at 350ºC and WHSV=2.5h8-1 was studied. The catalysts were prepared by ion exchange from a Ga(NO32 solution and further submitted to calcination in air at 530ºC. TEM analysis with an EDAX detector and TPR-H2 data showed that after calcination the Ga species were present mainly as Ga2O3, which are reduced to Ga2O at temperatures near 610ºC. The specific acid activity (SAA of the catalysts increased with the increase in aluminum content in the zeolite, and for a fixed Si/Al ratio, the SAA increased with Ga content. Values for specific hydro/dehydrogenation activity (SH/DHA were significantly higher than those for SAA, indicating that the catalytic process is controlled by the kinetics on acid sites. Moreover, the production of iso-butene with a selectivity higher than 25% was a evidence that in gallium/HZSM-5-based catalysts the rate of the hydrogenation reaction is lower than that of the dehydrogenation reaction; this behavior confirmed the dehydrogenation nature of gallium species, thereby showing great promise for iso-butene production.

  20. The soul of the machine: continual improvement in ISO 14001

    NARCIS (Netherlands)

    Brouwer, M.A.C.; van Koppen, C.S.A.

    2008-01-01

    Continual improvement is a key component of ISO 14001, but in contrast to most other specifications in the standard, it is difficult to assess. Based on interviews with 19 certified companies in the chemical, food, and environmental services sectors, this article explores the dynamics of continual