WorldWideScience

Sample records for irradiador js-6500 despues

  1. Dosimetry of the JS-6500 industrial irradiator for the irradiation of the PVC graduated flasks; Dosimetria del irradiador industrial JS-6500 para la irradiacion de probetas de PVC

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda F, A.; Carrasco A, H.; Martinez P, M.E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The dosimetry of the JS-6500 AECL irradiator was realized, outside of the industrial transportation rails to know the dose distribution, as well as its dose speed. This one with the intention of exposing to gamma radiation; plastified PVC graduated flasks and evaluating their interweavement or degradation or both. This study of dosimetry was carried out by means of a theoretical and experimental evaluation in air atmosphere. The results allow to know the irradiation conditions of the PVC graduated flasks as well as those results prove that has not a significant difference among the obtained result as theoretical as experimentally due to that the obtained result in the theoretical evaluation is 2.62 KGy/h and the result for the case of the experimental evaluation is 2.74 KGy/h. (Author)

  2. Reload of cobalt 60 for the J S-6500 irradiator; Recarga de cobalto 60 para el irradiador JS-6500

    Energy Technology Data Exchange (ETDEWEB)

    Torres C, G; Mayoral G, V M

    1991-01-15

    The present work has the purpose to describe the activities of the reloads program of the industrial irradiator J S-6500, elaborated for satisfying part of the demand of services and as a first step, to guide the decision making by the part of the ININ authorities in front of a wide market of this service. (Author)

  3. Dose distribution, using homogeneous material before the reload of the JS-6500 irradiator

    International Nuclear Information System (INIS)

    Carrasco A, H.

    1991-10-01

    The objective of this report is to determine the dose distribution inside the aluminum containers used for the industrial irradiation, as well as to locate the positions of maximum and minimum doses, before the reloading of the JS-6500 Irradiator. (Author)

  4. Dosimetry of the JS-6500 industrial irradiator for the irradiation of the PVC graduated flasks

    International Nuclear Information System (INIS)

    Castaneda F, A.; Carrasco A, H.; Martinez P, M.E.

    2002-01-01

    The dosimetry of the JS-6500 AECL irradiator was realized, outside of the industrial transportation rails to know the dose distribution, as well as its dose speed. This one with the intention of exposing to gamma radiation; plastified PVC graduated flasks and evaluating their interweavement or degradation or both. This study of dosimetry was carried out by means of a theoretical and experimental evaluation in air atmosphere. The results allow to know the irradiation conditions of the PVC graduated flasks as well as those results prove that has not a significant difference among the obtained result as theoretical as experimentally due to that the obtained result in the theoretical evaluation is 2.62 KGy/h and the result for the case of the experimental evaluation is 2.74 KGy/h. (Author)

  5. Statistical analysis of the irradiation process of various products in the industrial irradiator JS-6500; Analisis estadistico del proceso de irradiacion de productos varios en el irradiador industrial JS-6500

    Energy Technology Data Exchange (ETDEWEB)

    Naquid G, C [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    In this work the methodology for the control of the irradiation service applied to disposable products of medical use, foods, medications, cosmetics and several to different dose in the Gamma Irradiation Plant, with radiation of Cobalt 60, by means of the Graphs of Quality Control by Variables. These they are used to check if the irradiation process has been carried out appropriately, or well, if the variations surpass the established limits in the one that influences some another factor. (Author)

  6. Design of device for testing in the gamma irradiator; Diseno de dispositivo para pruebas en el irradiador gamma

    Energy Technology Data Exchange (ETDEWEB)

    Mariano H, E

    1991-02-15

    In eves of the recharge of the Gamma Irradiator, JS-6500 it was detected, that there was contamination in the container that housed the pencils of Co-60, coming from Argentina, country to which the ININ buys it recharges. It was determined that the contamination in the container was it interns and after discussing several solution options it was determined to manufacture a device to make a washing of the pencils. It was touch to the Management of Radiological Safety to determine the conceptual design of the device to make the washing and the way of operation of the same one. The Management of Prototypes and Models was responsibility of the mechanical design and its production. (Author)

  7. RootJS: Node.js Bindings for ROOT 6

    Science.gov (United States)

    Beffart, Theo; Früh, Maximilian; Haas, Christoph; Rajgopal, Sachin; Schwabe, Jonas; Wolff, Christoph; Szuba, Marek

    2017-10-01

    We present rootJS, an interface making it possible to seamlessly integrate ROOT 6 into applications written for Node.js, the JavaScript runtime platform increasingly commonly used to create high-performance Web applications. ROOT features can be called both directly from Node.js code and by JIT-compiling C++ macros. All rootJS methods are invoked asynchronously and support callback functions, allowing non-blocking operation of Node.js applications using them. Last but not least, our bindings have been designed to platform-independent and should therefore work on all systems supporting both ROOT 6 and Node.js. Thanks to rootJS it is now possible to create ROOT-aware Web applications taking full advantage of the high performance and extensive capabilities of Node.js. Examples include platforms for the quality assurance of acquired, reconstructed or simulated data, book-keeping and e-log systems, and even Web browser-based data visualisation and analysis.

  8. 21 CFR 880.6500 - Medical ultraviolet air purifier.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical ultraviolet air purifier. 880.6500 Section 880.6500 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... to ultraviolet radiation. (b) Classification. Class II (performance standards). ...

  9. jsGraph and jsNMR—Advanced Scientific Charting

    Directory of Open Access Journals (Sweden)

    Norman Pellet

    2014-09-01

    Full Text Available The jsGraph library is a versatile javascript library that allows advanced charting to be rendered interactively in web browsers without relying on server-side image processing. jsGraph is released under the MIT license and is free of charge. While being highly customizable through an intuitive javascript API, jsGraph is optimized to render a large quantity of data in a short amount of time. jsGraphs can display line, scatter, contour or zone series. Examples can be consulted on the project home page [1]. Customization of the chart, its axis and its series is achieved through simple but comprehensive JSON configurations.

  10. Professional AngularJS

    CERN Document Server

    Karpov, Valeri

    2015-01-01

    A comprehensive guide to AngularJS, Google's open-source client-side framework for app development. Most of the existing guides to AngularJS struggle to provide simple and understandable explanations for more advanced concepts. As a result, some developers who understand all the basic concepts of AngularJS struggle when it comes to building more complex real-world applications. Professional AngularJS provides a thorough understanding of AngularJS, covering everything from basic concepts, such as directives and data binding, to more advanced concepts like transclusion, build systems, and auto

  11. Cytoscape tools for the web age: D3.js and Cytoscape.js exporters

    OpenAIRE

    Ono, Keiichiro; Demchak, Barry; Ideker, Trey

    2014-01-01

    In this paper we present new data export modules for Cytoscape 3 that can generate network files for Cytoscape.js and D3.js. Cytoscape.js exporter is implemented as a core feature of Cytoscape 3, and D3.js exporter is available as a Cytoscape 3 app. These modules enable users to seamlessly export network and table data sets generated in Cytoscape to popular JavaScript library readable formats. In addition, we implemented template web applications for browser-based interactive network visualiz...

  12. Express.js blueprints

    CERN Document Server

    Augarten, Ben; Lin, Eric; Shaikh, Aidha; Soriani, Fabiano Pereira; Tisserand, Geoffrey; Zhang, Chiqing; Zhang, Kan

    2015-01-01

    This book is for beginners to Node.js and also for those who are technically advanced. By the end of this book, every competent developer will have achieved expertise in building web applications with Express.js.

  13. Vue.js 2 cookbook build modern, interactive web applications with Vue.js

    CERN Document Server

    Passaglia, Andrea

    2017-01-01

    Vue.js is an open source JavaScript library for building modern, interactive web applications. With a rapidly growing community and a strong ecosystem, Vue.js makes developing complex single page applications a breeze. Its component-based approach, intuitive API, blazing fast core, and compact size make Vue.js a great solution to craft your next front-end application. From basic to advanced recipes, this book arms you with practical solutions to common tasks when building an application using Vue. We start off by exploring the fundamentals of Vue.js: its reactivity system, data-binding syntax, and component-based architecture through practical examples. After that, we delve into integrating Webpack and Babel to enhance your development workflow using single file components. Finally, we take an in-depth look at Vuex for state management and Vue Router to route in your single page applications, and integrate a variety of technologies ranging from Node.js to Electron, and Socket.io to Firebase and HorizonDB. ...

  14. SymJS

    DEFF Research Database (Denmark)

    Andreasen, Esben; Li, Guodong; Ghosh, Indradeep

    2014-01-01

    We present SymJS, a comprehensive framework for automatic testing of client-side JavaScript Web applications. The tool contains a symbolic execution engine for JavaScript, and an automatic event explorer for Web pages. Without any user intervention, SymJS can automatically discover and explore Web...... events, symbolically execute the associated JavaScript code, refine the execution based on dynamic feedbacks, and produce test cases with high coverage. The symbolic engine contains a symbolic virtual machine, a string-numeric solver, and a symbolic executable DOM model. SymJS’s innovations include...... a novel symbolic virtual machine for JavaScript Web, symbolic+dynamic feedback directed event space exploration, and dynamic taint analysis for enhancing event sequence construction. We illustrate the effectiveness of SymJS on standard JavaScript benchmarks and various real-life Web applications...

  15. Ext JS 4 First Look

    CERN Document Server

    Groner, Loiane

    2012-01-01

    This book is a practical step-by-step tutorial which guides you to migrate from Ext JS 3 to Ext JS 4. There are examples backed with explanations and plenty of code and illustrations to look forward to. This book is written for web developers who are familiar with Ext JS 3 and want to have detailed insights into the new features of Ext JS 4.

  16. Mastering Ext JS

    CERN Document Server

    Groner, Loiane

    2013-01-01

    Designed to be a structured guide, Mastering Ext JS is full of engaging examples to help you learn in a practical context.This book is for developers who are familiar with using Ext JS who want to augment their skills to create even better web applications.

  17. Instant typeahead.js

    CERN Document Server

    Osbourn, Toby

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Instant Typeahead.js is a concise guide with 14 recipes which deals with everything you need to know to become proficient in using this tool and teaches you how to integrate it with other popular projects such as WordPress, Bootstrap, and Ruby on Rails.Instant Typeahead.js is for any web developer who would like to learn more about Typeahead.js in terms of what it can offer and the best ways to achieve common tasks. This book assumes no prior knowledge, but an understanding of JavaS

  18. Data-oriented development with AngularJS

    CERN Document Server

    Waikar, Manoj

    2015-01-01

    This book helps beginner-level AngularJS developers organize AngularJS applications by discussing important AngularJS concepts and best practices. If you are an experienced AngularJS developer but haven't written directives or haven't created custom HTML controls before, then this book is ideal for you.

  19. Instant Zepto.js

    CERN Document Server

    Pointer, Ian

    2013-01-01

    A simple starter guide that will walk you through Zepto.js from installation to more advanced topics using a step-by-step approach with useful examples included along the way.Instant Zepto.js is designed for web developers with some jQuery experience who are interested in speeding up and enhancing their web applications, especially on mobile devices.

  20. Learning Ext JS

    CERN Document Server

    Méndez, Carlos A; Gonzalez, Armando

    2015-01-01

    If you are a JavaScript developer who now wants to use the Ext JS framework, this is the book for you. This guide is useful to you whether you're new to Ext JS 5 or are a seasoned expert. Experience in HTML, CSS, and JavaScript is required in order to understand and get the most out of this book.

  1. Beginning Amazon Web Services with Node.js

    CERN Document Server

    Shackelford, Adam

    2015-01-01

    Beginning Amazon Web Services with Node.js teaches any novice Node.js developer to configure, deploy, and maintain scalable small to large scale Node.js applications in Amazon Web Services. Hosting a Node.js application in a production environment usually means turning to PaaS hosting, but this approach brings problems. Deploying Node.js directly to AWS solves the problems you encounter in these situations, enabling you to cut out the middle man. You will begin with a basic RESTful web service in Node.js, using the popular Express.js framework, pre-built and ready to run in your local env

  2. AngularJS : yksisivuisen web-sovelluksen käyttöliittymän toteutus AngularJS:llä

    OpenAIRE

    Suomijoki, Juha

    2015-01-01

    Opinnäytetyössä tutkittiin mikä on AngularJS-JavaScript-ohjelmistokehys ja miten se soveltuu yksisivuisen web-sovelluksen käyttöliittymän toteutukseen. AngularJS on vuonna 2012 julkaistu Googlen ylläpitämä JavaScript-ohjelmistokehys, joka on tarkoitettu ensisijaisesti yksisivuisten web-sovellusten kehittämiseen. Opinnäytetyön teoriaosuudessa tutkittiin mikä AngularJS on ja mitkä ovat AngularJS:n keskeiset konseptit ja sovelluskomponentit. Tarkastelu pohjautui AngularJS:stä kirjoitettu...

  3. Cytoscape tools for the web age: D3.js and Cytoscape.js exporters.

    Science.gov (United States)

    Ono, Keiichiro; Demchak, Barry; Ideker, Trey

    2014-01-01

    In this paper we present new data export modules for Cytoscape 3 that can generate network files for Cytoscape.js and D3.js. Cytoscape.js exporter is implemented as a core feature of Cytoscape 3, and D3.js exporter is available as a Cytoscape 3 app. These modules enable users to seamlessly export network and table data sets generated in Cytoscape to popular JavaScript library readable formats. In addition, we implemented template web applications for browser-based interactive network visualization that can be used as basis for complex data visualization applications for bioinformatics research. Example web applications created with these tools demonstrate how Cytoscape works in modern data visualization workflows built with traditional desktop tools and emerging web-based technologies. This interactivity enables researchers more flexibility than with static images, thereby greatly improving the quality of insights researchers can gain from them.

  4. Learning Vue.js 2 learn how to build amazing and complex reactive web applications easily with Vue.js

    CERN Document Server

    Filipova, Olga

    2016-01-01

    About This Book Learn how to propagate DOM changes across the website without writing extensive jQuery callbacks code. Learn how to achieve reactivity and easily compose views with Vue.js and understand what it does behind the scenes. Explore the core features of Vue.js with small examples, learn how to build dynamic content into preexisting web applications, and build Vue.js applications from scratch. Who This Book Is For This book is perfect for novice web developer seeking to learn new technologies or frameworks and also for webdev gurus eager to enrich their experience. Whatever your level of expertise, this book is a great introduction to the wonderful world of reactive web apps. What You Will Learn Build a fully functioning reactive web application in Vue.js from scratch. The importance of the MVVM architecture and how Vue.js compares with other frameworks such as Angular.js and React.js. How to bring reactivity to an existing static application using Vue.js. How to use p...

  5. AngularJS Performance: A Survey Study

    OpenAIRE

    Ramos, Miguel; Valente, Marco Tulio; Terra, Ricardo

    2017-01-01

    AngularJS is a popular JavaScript MVC-based framework to construct single-page web applications. In this paper, we report the results of a survey with 95 professional developers about performance issues of AngularJS applications. We report common practices followed by developers to avoid performance problems (e.g., use of third-party or custom components), the general causes of performance problems in AngularJS applications (e.g., inadequate architecture decisions taken by AngularJS users), a...

  6. Instant AngularJS starter

    CERN Document Server

    Menard, Dan

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is written in an easytoread style, with a strong emphasis on realworld, practical examples. Stepbystep explanations are provided for performing important tasks.This book is for web developers familiar with JavascriptIt doesn't cover the history of AngularJS, and it's not a pitch to convince you that AngularJS is the best framework on the entire web. It's a guide to help you learn everything you need to know about AngularJS in as few pa

  7. AngularJS testing cookbook

    CERN Document Server

    Bailey, Simon

    2015-01-01

    This book is intended for developers who have an understanding of the basic principles behind both AngularJS and test-driven development. You, as a developer, are interested in eliminating the fear related to either introducing tests to an existing codebase or starting out testing on a fresh AngularJS application. If you're a team leader or part of a QA team with the responsibility of ensuring full test coverage of an application, then this book is ideal for you to comprehend the full testing scope required by your developers. Whether you're new to or are well versed with AngularJS, this book

  8. Learning Less.js

    CERN Document Server

    Libby, Alex

    2014-01-01

    If you are a designer or developer who wants to quickly learn how to harness the power of Less.js to write more efficient CSS styles that can be applied to a website of any size, then this book is for you. This book will help you master both the basic functions and advanced features of Less.js. It would be helpful to have some familiarity of writing CSS styles, although no prior experience of using CSS preprocessors is required.

  9. AngularJS test-driven development

    CERN Document Server

    Chaplin, Tim

    2015-01-01

    This book is for developers who want to learn about AngularJS development by applying testing techniques. You are assumed to have a basic knowledge and understanding of HTML, JavaScript, and AngularJS.

  10. 20 CFR 653.106 - JS day-haul responsibilities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false JS day-haul responsibilities. 653.106 Section... THE EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.106 JS day... Regional Administrator is obtained. (b) No JS applicants shall be referred to non-JS operated day-haul...

  11. Ember.js web development with Ember CLI

    CERN Document Server

    Puri, Suchit

    2015-01-01

    If you are a JavaScript developer who is starting out to build ambitious Ember.js application, or a developer who has prior Ember.js experience and want to transition your application to the latest Ember.js version with Ember CLI, then this book is for you.

  12. AngularJS web application development

    CERN Document Server

    Darwin, Peter Bacon

    2013-01-01

    The book will be a step-by-step guide showing the readers how to build a complete web app with AngularJSJavaScript developers who want to learn AngularJS for developing web apps. Knowledge of JavaScript and HTML is expected. No knowledge of AngularJS is required.

  13. Should we be screening for anti-Js(a)?

    Science.gov (United States)

    Nikolis, Nancy M; Boctor, Fouad; Heaton, William Andrew; Martone, James

    2011-01-01

    We analyzed our historic patient database at North Shore University Hospital and determined both the overall frequency of anti-Js(a) and the frequency at which it was detected in combination with other alloantibodies to red blood cell (RBC) antigens. Screening cells used currently are negative for Js(a). Our data suggest that anti-Js(a) would not be detected in 30 to 40 percent of patients in which it is the sole antibody present. Since 1996 the antibody was only detected when other antibodies were found in the screening process. We are exposing 1.7 percent of our patients (90 patients/year) to Js(a). The clinical significance of anti-Js(a) is apparent with previous literature, and our conclusion is that additional studies should be performed to determine whether Js(a) should be included in current antibody screening cells.

  14. 20 CFR 658.421 - Handling of JS-related complaints.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Handling of JS-related complaints. 658.421... ADMINISTRATIVE PROVISIONS GOVERNING THE JOB SERVICE SYSTEM Job Service Complaint System Federal Js Complaint System § 658.421 Handling of JS-related complaints. (a) No JS-related complaint shall be handled at the...

  15. 20 CFR 658.415 - Transferring complaints to proper JS office.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Transferring complaints to proper JS office... Agency Js Complaint System § 658.415 Transferring complaints to proper JS office. (a) Where a JS-related... local office serving the area in which the employer is located. Where a JS-related complaint deals with...

  16. Data visualization with D3 and AngularJS

    CERN Document Server

    Körner, Christoph

    2015-01-01

    If you are a web developer with experience in AngularJS and want to implement interactive visualizations using D3.js, this book is for you. Knowledge of SVG or D3.js will give you an edge to get the most out of this book.

  17. Responsive web design with AngularJS

    CERN Document Server

    Patel, Sandeep Kumar

    2014-01-01

    If you are an AngularJS developer who wants to learn about responsive web application development, this book is ideal for you. Responsive Web Design with AngularJS is intended for web developers or designers with a basic knowledge of HTML, CSS, and JavaScript.

  18. Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma.

    Science.gov (United States)

    Fatima, Sarwat; Chui, Chung H; Tang, Wing K; Hui, Kin S; Au, Ho W; Li, Wing Y; Wong, Mei M; Cheung, Filly; Tsao, S W; Lam, King Y; Beh, Philip S L; Wong, John; Law, Simon; Srivastava, Gopesh; Ho, Kwok P; Chan, Albert S C; Tang, Johnny C O

    2006-01-01

    Esophageal squamous cell carcinoma (ESCC) has a high mortality rate and geographic differences in incidence. Previous studies of comparative genomic hybridization (CGH) showed that chromosomal 5p is frequently amplified in cell lines and primary ESCC of Hong Kong Chinese origin. In this report, attempt was made to study two novel genes, named as JS-1 and JS-2, which are located in chromosome 5p15.2 and are 5' upstream to delta catenin for their roles in molecular pathogenesis of ESCC. Eleven cell lines, 27 primary ESCC cases and multiple human tissue cDNA panels (MTC) of digestive system were studied for the expression level of JS-1 and JS-2 by RT-PCR. The full-length cDNA sequences of JS-1 and JS-2 were determined from a non-tumor esophageal epithelial cell line by 3' and 5' rapid amplification of cDNA ends (RACE). The transforming capacity of JS-1 and JS-2 was also investigated by transfecting NIH 3T3 cells with the expression vector pcDNA3.1(-) cloned with the full coding sequences and it was followed by the study of foci formation of the transfected cells under confluence growth and the anchorage-independent growth in soft agar. Forty-five percent (5/11) and 18% (2/11) of the ESCC cell lines showed overexpression of JS-1 and JS-2 respectively, while 55% (15/27) and 14% (3/22) primary ESCC cases showed overexpression of JS-1 and JS-2 respectively. JS-1 overexpression was most common in patients with stage II ESCC (6/27; 22%) whereas JS-2 was only overexpressed in a dysplastic lesion (1/22; 4%) and stage III tumors (2/22; 9%). The expression levels of JS-1 and JS-2 are both low in normal esophageal tissues. Overexpression of JS-1 in NIH 3T3 cells caused foci formation in confluence growth and colony formation in soft agar but not for JS-2. A high grade sarcoma was formed in the athymic nude mice when NIH 3T3 cells overexpressing JS-1 were injected subcutaneously. Our results thus indicate that the frequent overexpression of JS-1 in ESCC and its transforming

  19. Practical Ext JS Projects with Gears

    CERN Document Server

    Zammetti, Frank

    2009-01-01

    Discover Ext JS, one of today's most powerful and highly regarded JavaScript frameworks, with perhaps the best set of GUI widgets around, and a whole host of components that make developing client--side applications a breeze. Using a pragmatic approach, you'll dissect seven full--fledged applications, covering *How Ext JS allows you to create these applications with a slick user interface with a minimum of effort*How the other parts of Ext JS aside from the GUI widgets provide many of the capabilities modern applications need, such as Ajax and data mechanisms *How other technologies such as Ge

  20. Connecting YARP to the Web with Yarp.js

    Directory of Open Access Journals (Sweden)

    Carlo Ciliberto

    2017-12-01

    Full Text Available We present yarp.js, a JavaScript framework enabling robotics networks to interface and interact with external devices by exploiting modern Web communication protocols. By connecting a YARP server module with a browser client on any external device, yarp.js allows to access on board sensors using standard Web APIs and stream the acquired data through the yarp.js network without the need for any installation. Communication between YARP modules and yarp.js clients is bi-directional, opening also the possibility for robotics applications to exploit the capabilities of modern browsers to process external data, such as speech synthesis, 3D data visualization, or video streaming to name a few. Yarp.js requires only a browser installed on the client device, allowing for fast and easy deployment of novel applications. The code and sample applications to get started with the proposed framework are available for the community at the yarp.js GitHub repository.

  1. Reload of cobalt 60 for the J S-6500 irradiator

    International Nuclear Information System (INIS)

    Torres C, G.; Mayoral G, V.M.

    1991-01-01

    The present work has the purpose to describe the activities of the reloads program of the industrial irradiator J S-6500, elaborated for satisfying part of the demand of services and as a first step, to guide the decision making by the part of the ININ authorities in front of a wide market of this service. (Author)

  2. パラオ海溝の深海6500mに存在する石灰岩体の溶解

    OpenAIRE

    坪井, 辰哉; 和田, 秀樹; 中村, 俊夫; 松崎, 浩之; 大辻, 菜穂; 藤岡, 換太郎; 小栗, 一将; 北里, 洋; Tsuboi, Tatsuya; Wada, Hideki; Nakamura, Toshio; Matsuzaki, Hiroyuki; Otsuji, Naho; Fujioka, Kantaro; Oguri, Kazumasa

    2013-01-01

    The large limestone block was found at 6500m depth of Palau Trench in 1993. The Sr isotopic age of this limestone shows the accumulation age of late Miocene. Using the submersible Shinkai 6500, we report the 14C density of seawater collected around the large limestone block on the landward slope of the Palau Trench, at around 6500m depth, which is significantly deeper than the carbonate compensation depth (CCD). AMS-14C measurements of dissolved inorganic carbon (DIC) extracted revealed value...

  3. blastjs: a BLAST+ wrapper for Node.js.

    Science.gov (United States)

    Page, Martin; MacLean, Dan; Schudoma, Christian

    2016-02-27

    To cope with the ever-increasing amount of sequence data generated in the field of genomics, the demand for efficient and fast database searches that drive functional and structural annotation in both large- and small-scale genome projects is on the rise. The tools of the BLAST+ suite are the most widely employed bioinformatic method for these database searches. Recent trends in bioinformatics application development show an increasing number of JavaScript apps that are based on modern frameworks such as Node.js. Until now, there is no way of using database searches with the BLAST+ suite from a Node.js codebase. We developed blastjs, a Node.js library that wraps the search tools of the BLAST+ suite and thus allows to easily add significant functionality to any Node.js-based application. blastjs is a library that allows the incorporation of BLAST+ functionality into bioinformatics applications based on JavaScript and Node.js. The library was designed to be as user-friendly as possible and therefore requires only a minimal amount of code in the client application. The library is freely available under the MIT license at https://github.com/teammaclean/blastjs.

  4. 20 CFR 658.411 - Filing and assignment of JS-related complaints.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Filing and assignment of JS-related... Agency Js Complaint System § 658.411 Filing and assignment of JS-related complaints. (a) JS-related... office personnel shall be as follows: (1) All JS-related complaints filed with a local office, and...

  5. Exposing Library Services with AngularJS

    OpenAIRE

    Jakob Voß; Moritz Horn

    2014-01-01

    This article provides an introduction to the JavaScript framework AngularJS and specific AngularJS modules for accessing library services. It shows how information such as search suggestions, additional links, and availability can be embedded in any website. The ease of reuse may encourage more libraries to expose their services via standard APIs to allow usage in different contexts.

  6. A Quantitative Measure of JS's Memory

    Science.gov (United States)

    Ben Shalom, Dorit; Faran, Yifat; Boucher, Jill

    2010-01-01

    JS is a highly able, well-educated 37 year old man with Asperger syndrome. A recent qualitative paper (Boucher, 2007) described his self-report of verbal and visual memory difficulties. The present paper used the WMS-III to compare the memory profile of JS to that of the adults with HFA in the Williams et al. (2005) WMS-III paper. Results show…

  7. 20 CFR 658.416 - Action on JS-related complaints.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Action on JS-related complaints. 658.416... ADMINISTRATIVE PROVISIONS GOVERNING THE JOB SERVICE SYSTEM Job Service Complaint System State Agency Js Complaint System § 658.416 Action on JS-related complaints. (a) The appropriate State agency official handling an...

  8. 32 CFR 311.7 - OSD/JS Privacy Office Processes.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false OSD/JS Privacy Office Processes. 311.7 Section...) PRIVACY PROGRAM OFFICE OF THE SECRETARY OF DEFENSE AND JOINT STAFF PRIVACY PROGRAM § 311.7 OSD/JS Privacy Office Processes. The OSD/JS Privacy Office shall: (a) Exercise oversight and administrative control of...

  9. Deploying Node.js

    CERN Document Server

    Pasquali, Sandro

    2015-01-01

    If you are an intermediate or advanced developer deploying your Node.js applications, then this book is for you. If you have already built a Node application or module and want to take your knowledge to the next level, this book will help you find your way.

  10. Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.

    Science.gov (United States)

    Wang, Chun-Mei; Guan, Wei; Fang, Shu; Chen, Hao; Li, You-Qin; Cai, Chun; Fan, Yong-Jian; Shi, Zhi-Qi

    2010-08-01

    JS-B (C(12)H(10)O(3)) is a derivative compound of osthol. The antifungal properties of JS-B were tested against 10 economically important plant pathogens. JS-B was effective in inhibiting the mycelial growth of Phytophthora capsici, and its inhibition on different stages of the life cycle of P. capsici was observed. The 50% effective concentration (EC(50)) of JS-B on mycelial dry weight and zoospore germination of P. capsici was 43.74 and 86.03 microg/ml, respectively. The rupture of released zoospores induced by JS-B was reduced by the addition of 100 mM glucose. The ultrastructural study showed that JS-B caused destruction of most of the mitochondrions, the concentration of cell nuclear, and the existing vesicles. When compared with dimethomorph, the activity of JS-B on P. capsici was determined under pot conditions. The result showed that JS-B has a curative effect on pepper blight.

  11. 20 CFR 658.410 - Establishment of State agency JS complaint system.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Establishment of State agency JS complaint... Agency Js Complaint System § 658.410 Establishment of State agency JS complaint system. (a) Each State... State Administrator shall have overall responsibility for the operation of the State agency JS complaint...

  12. Mastering Ext JS

    CERN Document Server

    Groner, Loiane

    2015-01-01

    If you are a developer who is familiar with Ext JS and want to augment your skills to create even better web applications, this is the book for you. Basic knowledge of JavaScript/HTML/CSS and any server-side language (PHP, Java, C#, Ruby, or Python) is required.

  13. KnockoutJS blueprints

    CERN Document Server

    Russo, Carlo

    2015-01-01

    If you are a JavaScript developer and already know the basics of KnockoutJS and you want to get the most out of it, then this book is for you. This book will help in your transition from a small site to a large web application that is easily maintainable.

  14. Altered JS-2 expression in colorectal cancers and its clinical pathological relevance.

    Science.gov (United States)

    Lam, Alfred King-Yin; Gopalan, Vinod; Nassiri, Mohammad Reza; Kasim, Kais; Dissanayake, Jayampathy; Tang, Johnny Chuek-On; Smith, Robert Anthony

    2011-10-01

    JS-2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS-2 in colorectal cancer. The aim of this study is to determine the gene copy number and expression of JS-2 in a large cohort of patients with colorectal tumours and correlate these to the clinicopathological features of the cancer patients. We evaluated the DNA copy number and mRNA expression of JS-2 in 176 colorectal tissues (116 adenocarcinomas, 30 adenomas and 30 non-neoplastic tissues) using real-time polymerase chain reaction. JS-2 expression was also evaluated in two colorectal cancer cell lines and a benign colorectal cell line. JS-2 amplification was noted in 35% of the colorectal adenocarcinomas. Significant differences in relative expression levels for JS-2 mRNA between different colorectal tissues were noted (p = 0.05). Distal colorectal adenocarcinoma had significantly higher copy number than proximal adenocarcinoma (p = 0.005). The relative expression level of JS-2 was different between colonic and rectal adenocarcinoma (p = 0.007). Mucinous adenocarcinoma showed higher JS-2 expression than non-mucinous adenocarcinoma (p = 0.02). Early T-stage cancers appear to have higher JS-2 copy number and lower expression of JS-2 mRNA than later stage cancers (p = 0.001 and 0.03 respectively). Colorectal cancer cell lines showed lower expression of JS-2 than the benign colorectal cell line. JS-2 copy number change and expression were shown for the first time to be altered in the carcinogenesis of colorectal cancer. In addition, genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer. Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  15. Cytoscape.js: a graph theory library for visualisation and analysis.

    Science.gov (United States)

    Franz, Max; Lopes, Christian T; Huck, Gerardo; Dong, Yue; Sumer, Onur; Bader, Gary D

    2016-01-15

    Cytoscape.js is an open-source JavaScript-based graph library. Its most common use case is as a visualization software component, so it can be used to render interactive graphs in a web browser. It also can be used in a headless manner, useful for graph operations on a server, such as Node.js. Cytoscape.js is implemented in JavaScript. Documentation, downloads and source code are available at http://js.cytoscape.org. gary.bader@utoronto.ca. © The Author 2015. Published by Oxford University Press.

  16. 20 CFR 658.414 - Referral of non-JS-related complaints.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Referral of non-JS-related complaints. 658... ADMINISTRATIVE PROVISIONS GOVERNING THE JOB SERVICE SYSTEM Job Service Complaint System State Agency Js Complaint System § 658.414 Referral of non-JS-related complaints. (a) To facilitate the operation of the...

  17. HTML5 game programming with enchant.js

    CERN Document Server

    Shimizu, Ryo; Fushimi, Ryohei; Tanaka, Ryo; Kratzer, Kevin; McInnis, Brandon; Inc, enchantjs

    2013-01-01

    Official book from the developers of enchant.js. Enchant.js is open source, so there is no barrier for entry. Provides aspiring game developers with a tool to program fully-fledged games quickly and easily. Teaches the basics of HTML5 and JavaScript, invaluable tools for budding programmers. Shares invaluable tips from professional game developers for creating compelling game design and content.

  18. 3Dmol.js: molecular visualization with WebGL.

    Science.gov (United States)

    Rego, Nicholas; Koes, David

    2015-04-15

    3Dmol.js is a modern, object-oriented JavaScript library that uses the latest web technologies to provide interactive, hardware-accelerated three-dimensional representations of molecular data without the need to install browser plugins or Java. 3Dmol.js provides a full featured API for developers as well as a straightforward declarative interface that lets users easily share and embed molecular data in websites. 3Dmol.js is distributed under the permissive BSD open source license. Source code and documentation can be found at http://3Dmol.csb.pitt.edu dkoes@pitt.edu. © The Author 2014. Published by Oxford University Press.

  19. KnockoutJS web development

    CERN Document Server

    Farrar, John

    2015-01-01

    This book is for web developers and designers who work with HTML and JavaScript to help them manage data and interactivity with data using KnockoutJS. Knowledge about jQuery will be useful but is not necessary.

  20. AngularJS yksisivuisen web-applikaation kehitysalustana

    OpenAIRE

    Karhu, Tuomo

    2015-01-01

    Yksisivuiset web-applikaatiot (SPA-sovellukset) ovat yleistyneet viimeisten kymmenen vuoden aikana, ja näiden avulla on ollut mahdollista tuoda verkkosivuston käyttökokemus lähemmäksi aitojen ohjelmasovellusten vastaavaa. Yksisivuisten web-applikaatioitten kehitystyöhön tarkoitetuista sovelluskehyksistä AngularJS on yksi käytetyimmistä ja suosituimmista. Työn tavoitteena on selvittää miten AngularJS-sovelluskehys soveltuu SPA-sivustojen kehitykseen sovelluskehittäjän näkökulmasta, sekä mi...

  1. Learning Three.js the JavaScript 3D library for WebGL

    CERN Document Server

    Dirksen, Jos

    2013-01-01

    ""Learning Three.js is a hands-on guide which provides everything you need to start working with the powerful JavaScript library, and start creating awesome in-browser visualizations"".Learning Three.js is written for anyone looking to get started with Three.js, or looking to improve their skills with the popular js library. The book assumes some knowledge of javascript, but you don't need any knowledge of Three.js itself to follow the book.

  2. Learning web development with Bootstrap and AngularJS

    CERN Document Server

    Radford, Stephen

    2015-01-01

    Whether you know a little about Bootstrap or AngularJS, or you're a complete beginner, this book will enhance your capabilities in both frameworks and you'll build a fully functional web app. A working knowledge of HTML, CSS, and JavaScript is required to fully get to grips with Bootstrap and AngularJS.

  3. Building scalable apps with Redis and Node.js

    CERN Document Server

    Johanan, Joshua

    2014-01-01

    If the phrase scalability sounds alien to you, then this is an ideal book for you. You will not need much Node.js experience as each framework is demonstrated in a way that requires no previous knowledge of the framework. You will be building scalable Node.js applications in no time! Knowledge of JavaScript is required.

  4. Node.js by example

    CERN Document Server

    Tsonev, Krasimir

    2015-01-01

    If you are a JavaScript developer with no experience with Node.js or server-side web development, this book is for you. It will lead you through creating a fairly complex social network. You will learn how to work with a database and create real-time communication channels.

  5. EFFECT OF A PLURONIC® P123 FORMULATION ON THE NITRIC OXIDE-GENERATING DRUG JS-K

    Science.gov (United States)

    Kaur, Imit; Kosak, Ken M.; Terrazas, Moises; Herron, James N.; Kern, Steven E.; Boucher, Kenneth M.; Shami, Paul J.

    2014-01-01

    Purpose O2-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] or JS-K is a nitric oxide-producing prodrug of the arylated diazeniumdiolate class with promising anti-tumor activity. JS-K has challenging solubility and stability properties. We aimed to characterize and compare Pluronic® P123-formulated JS-K (P123/JS-K) with free JS-K. Methods We determined micelle size, shape, and critical micelle concentration of Pluronic® P123. Efficacy was evaluated in vitro using HL-60 and U937 cells and in vivo in a xenog raft in NOD/SCID IL2Rγnull mice using HL-60 cells. We compared JS-K and P123/JS-K stability in different media. We also compared plasma protein binding of JS-K and P123/JS-K. We determined the binding and Stern Volmer constants, and thermodynamic parameters. Results Spherical P123/JS-K micelles were smaller than blank P123. P123/JS-K formulation was more stable in buffered saline, whole blood, plasma and RPMI media as compared to free JS-K. P123 affected the protein binding properties of JS-K. In vitro it was as efficacious as JS-K alone when tested in HL-60 and U937 cells and in vivo greater tumor regression was observed for P123/JS-K treated NOD/SCID IL2Rγnull mice when compared to free JS-K-treated NOD/SCID IL2Rγnull mice. Conclusions Pluronic® P123 solubilizes, stabilizes and affects the protein binding characteristics of JS-K. P123/JS-K showed more in vivo anti-tumor activity than free JS-K. PMID:25330743

  6. 20 CFR 658.401 - Types of complaints handled by the JS complaint system.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Types of complaints handled by the JS... § 658.401 Types of complaints handled by the JS complaint system. (a)(1) The types of complaints (JS related complaints) which shall be handled to resolution by the JS complaint system are as follows: (i...

  7. AngularJS in the Wild: A Survey with 460 Developers

    OpenAIRE

    Ramos, Miguel; Valente, Marco Tulio; Terra, Ricardo; Santos, Gustavo

    2016-01-01

    To implement modern web applications, a new family of JavaScript frameworks has emerged, using the MVC pattern. Among these frameworks, the most popular one is AngularJS, which is supported by Google. In spite of its popularity, there is not a clear knowledge on how AngularJS design and features affect the development experience of Web applications. Therefore, this paper reports the results of a survey about AngularJS, including answers from 460 developers. Our contributions include the ident...

  8. Effect of a Pluronic(®) P123 formulation on the nitric oxide-generating drug JS-K.

    Science.gov (United States)

    Kaur, Imit; Kosak, Ken M; Terrazas, Moises; Herron, James N; Kern, Steven E; Boucher, Kenneth M; Shami, Paul J

    2015-04-01

    O(2)-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] or JS-K is a nitric oxide-producing prodrug of the arylated diazeniumdiolate class with promising anti-tumor activity. JS-K has challenging solubility and stability properties. We aimed to characterize and compare Pluronic(®) P123-formulated JS-K (P123/JS-K) with free JS-K. We determined micelle size, shape, and critical micelle concentration of Pluronic(®) P123. Efficacy was evaluated in vitro using HL-60 and U937 cells and in vivo in a xenograft in NOD/SCID IL2Rγ (null) mice using HL-60 cells. We compared JS-K and P123/JS-K stability in different media. We also compared plasma protein binding of JS-K and P123/JS-K. We determined the binding and Stern Volmer constants, and thermodynamic parameters. Spherical P123/JS-K micelles were smaller than blank P123. P123/JS-K formulation was more stable in buffered saline, whole blood, plasma and RPMI media as compared to free JS-K. P123 affected the protein binding properties of JS-K. In vitro it was as efficacious as JS-K alone when tested in HL-60 and U937 cells and in vivo greater tumor regression was observed for P123/JS-K treated NOD/SCID IL2Rγ (null) mice when compared to free JS-K-treated NOD/SCID IL2Rγ (null) mice. Pluronic(®) P123 solubilizes, stabilizes and affects the protein binding characteristics of JS-K. P123/JS-K showed more in vivo anti-tumor activity than free JS-K.

  9. Quality assurance systems at SKODA JS

    International Nuclear Information System (INIS)

    Janecek, P.

    2000-01-01

    In addition to technical requirements put upon the design, manufacture, installation and commissioning of equipment for nuclear power plants, emphasis is laid upon quality assurance of such activities so as to secure nuclear safety of installations over the world. As the technical level of nuclear safety assurance is being enhanced continuously, the requirements are becoming more and more stringent, which is mirrored by the relevant standards and legislation. SKODA JS has always been pursuing the quality goal and has been contributing to this aspect markedly. The quality assurance system at SKODA JS helps the company to satisfy all the appropriate requirements of its customers as well as the applicable standards and regulations. (author)

  10. Leucocytes DNA damage in mice exposed to JS-118 by the comet assay.

    Science.gov (United States)

    Zhang, Tao; Hu, Jiye; Zhang, Yuchao; Zhao, Qianfei; Ning, Jun

    2011-09-01

    JS-118 is an extensively used insecticide in China. The present study investigated the genotoxic effect of JS-118 on whole blood at 24, 48, 72 and 96 h by using alkaline comet assay. Male Kunming mice were given 6.25, 12.5, 25, 50 and 100 mg/kg BW of JS-118 intraperitoneally. A statistically significant increase in all comet parameters indicating DNA damage was observed at 24 h post-treatment (p JS-118 and the period of treatment. The present study provided further information of the potential risk of the genetic damage caused by JS-118.

  11. 20 CFR 658.420 - Establishment of JS complaint system at the ETA regional office.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Establishment of JS complaint system at the... Complaint System Federal Js Complaint System § 658.420 Establishment of JS complaint system at the ETA regional office. (a) Each Regional Administrator shall establish and maintain a JS complaint system at the...

  12. High performance geospatial and climate data visualization using GeoJS

    Science.gov (United States)

    Chaudhary, A.; Beezley, J. D.

    2015-12-01

    GeoJS (https://github.com/OpenGeoscience/geojs) is an open-source library developed to support interactive scientific and geospatial visualization of climate and earth science datasets in a web environment. GeoJS has a convenient application programming interface (API) that enables users to harness the fast performance of WebGL and Canvas 2D APIs with sophisticated Scalable Vector Graphics (SVG) features in a consistent and convenient manner. We started the project in response to the need for an open-source JavaScript library that can combine traditional geographic information systems (GIS) and scientific visualization on the web. Many libraries, some of which are open source, support mapping or other GIS capabilities, but lack the features required to visualize scientific and other geospatial datasets. For instance, such libraries are not be capable of rendering climate plots from NetCDF files, and some libraries are limited in regards to geoinformatics (infovis in a geospatial environment). While libraries such as d3.js are extremely powerful for these kinds of plots, in order to integrate them into other GIS libraries, the construction of geoinformatics visualizations must be completed manually and separately, or the code must somehow be mixed in an unintuitive way.We developed GeoJS with the following motivations:• To create an open-source geovisualization and GIS library that combines scientific visualization with GIS and informatics• To develop an extensible library that can combine data from multiple sources and render them using multiple backends• To build a library that works well with existing scientific visualizations tools such as VTKWe have successfully deployed GeoJS-based applications for multiple domains across various projects. The ClimatePipes project funded by the Department of Energy, for example, used GeoJS to visualize NetCDF datasets from climate data archives. Other projects built visualizations using GeoJS for interactively exploring

  13. 20 CFR 658.422 - Handling of non-JS-related complaints by the Regional Administrator.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Handling of non-JS-related complaints by the... Federal Js Complaint System § 658.422 Handling of non-JS-related complaints by the Regional Administrator. (a) Each non-JS-related complaint filed by an MSFW alleging violations of employment related laws...

  14. Observation of channeling for 6500 GeV/c protons in the crystal assisted collimation setup for LHC

    International Nuclear Information System (INIS)

    Scandale, W.; Arduini, G.; Butcher, M.; Cerutti, F.; Garattini, M.; Gilardoni, S.; Lechner, A.; Losito, R.; Masi, A.; Mirarchi, D.; Montesano, S.; Redaelli, S.; Rossi, R.; Schoofs, P.; Smirnov, G.; Valentino, G.; Breton, D.; Burmistrov, L.; Chaumat, V.; Dubos, S.

    2016-01-01

    Two high-accuracy goniometers equipped with two bent silicon crystals were installed in the betatron cleaning insertion of the CERN Large Hadron Collider (LHC) during its long shutdown. First beam tests were recently performed at the LHC with 450 GeV/c and 6500 GeV/c stored proton beams to investigate the feasibility of beam halo collimation assisted by bent crystals. For the first time channeling of 6500 GeV/c protons was observed in a particle accelerator. A strong reduction of beam losses due to nuclear inelastic interactions in the aligned crystal in comparison with its amorphous orientation was detected. The loss reduction value was about 24. Thus, the results show that deflection of particles by a bent crystal due to channeling is effective for this record particle energy.

  15. Observation of channeling for 6500 GeV/c protons in the crystal assisted collimation setup for LHC

    Energy Technology Data Exchange (ETDEWEB)

    Scandale, W. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); Laboratoire de l' Accelerateur Lineaire (LAL), Universite Paris Sud Orsay, Orsay (France); INFN Sezione di Roma, Piazzale Aldo Moro 2, 00185 Rome (Italy); Arduini, G.; Butcher, M.; Cerutti, F.; Garattini, M.; Gilardoni, S.; Lechner, A.; Losito, R.; Masi, A.; Mirarchi, D.; Montesano, S.; Redaelli, S. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); Rossi, R. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); INFN Sezione di Roma, Piazzale Aldo Moro 2, 00185 Rome (Italy); Schoofs, P. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); Smirnov, G. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); INFN Sezione di Roma, Piazzale Aldo Moro 2, 00185 Rome (Italy); Valentino, G. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); Breton, D.; Burmistrov, L.; Chaumat, V.; Dubos, S. [Laboratoire de l' Accelerateur Lineaire (LAL), Universite Paris Sud Orsay, Orsay (France); and others

    2016-07-10

    Two high-accuracy goniometers equipped with two bent silicon crystals were installed in the betatron cleaning insertion of the CERN Large Hadron Collider (LHC) during its long shutdown. First beam tests were recently performed at the LHC with 450 GeV/c and 6500 GeV/c stored proton beams to investigate the feasibility of beam halo collimation assisted by bent crystals. For the first time channeling of 6500 GeV/c protons was observed in a particle accelerator. A strong reduction of beam losses due to nuclear inelastic interactions in the aligned crystal in comparison with its amorphous orientation was detected. The loss reduction value was about 24. Thus, the results show that deflection of particles by a bent crystal due to channeling is effective for this record particle energy.

  16. Anatomy of BioJS, an open source community for the life sciences.

    Science.gov (United States)

    Yachdav, Guy; Goldberg, Tatyana; Wilzbach, Sebastian; Dao, David; Shih, Iris; Choudhary, Saket; Crouch, Steve; Franz, Max; García, Alexander; García, Leyla J; Grüning, Björn A; Inupakutika, Devasena; Sillitoe, Ian; Thanki, Anil S; Vieira, Bruno; Villaveces, José M; Schneider, Maria V; Lewis, Suzanna; Pettifer, Steve; Rost, Burkhard; Corpas, Manuel

    2015-07-08

    BioJS is an open source software project that develops visualization tools for different types of biological data. Here we report on the factors that influenced the growth of the BioJS user and developer community, and outline our strategy for building on this growth. The lessons we have learned on BioJS may also be relevant to other open source software projects.

  17. JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells.

    Science.gov (United States)

    Qiu, Mingning; Chen, Lieqian; Tan, Guobin; Ke, Longzhi; Zhang, Sai; Chen, Hege; Liu, Jianjun

    2017-03-01

    Reactive oxygen species (ROS) are chemical species that alter redox status, and are responsible for inducing carcinogenesis. The purpose of the present study was to assess the effects of the glutathione S transferase-activated nitric oxide donor prodrug, JS-K, on ROS accumulation and on proliferation and apoptosis in human prostate cancer cells. Cell proliferation and apoptosis, ROS accumulation and the activation of the mitochondrial signaling pathway were measured. The results demonstrated that JS-K may inhibit prostate cancer cell growth in a dose- and time-dependent manner, and induce ROS accumulation and apoptosis in a dose-dependent manner. With increasing concentrations of JS-K, expression of pro-apoptotic proteins increased, but Bcl-2 expression decreased. Additionally, the antioxidant N-acetylcysteine reversed JS-K-induced cell apoptosis; conversely, the pro-oxidant glutathione disulfide exacerbated JS-K-induced apoptosis. In conclusion, the data suggest that JS-K induces prostate cancer cell apoptosis by increasing ROS levels.

  18. Cytoscape tools for the web age: D3.js and Cytoscape.js exporters [v2; ref status: indexed, http://f1000r.es/4k7

    Directory of Open Access Journals (Sweden)

    Keiichiro Ono

    2014-10-01

    Full Text Available In this paper we present new data export modules for Cytoscape 3 that can generate network files for Cytoscape.js and D3.js. Cytoscape.js exporter is implemented as a core feature of Cytoscape 3, and D3.js exporter is available as a Cytoscape 3 app. These modules enable users to seamlessly export network and table data sets generated in Cytoscape to popular JavaScript library readable formats. In addition, we implemented template web applications for browser-based interactive network visualization that can be used as basis for complex data visualization applications for bioinformatics research. Example web applications created with these tools demonstrate how Cytoscape works in modern data visualization workflows built with traditional desktop tools and emerging web-based technologies. This interactivity enables researchers more flexibility than with static images, thereby greatly improving the quality of insights researchers can gain from them.

  19. AngularJS directives

    CERN Document Server

    Vanston, Alex

    2013-01-01

    This book uses a practical, step-by-step approach, starting with how to build directives from the ground up before moving on to creating web applications comprised of multiple modules all working together to provide the best user experience possible.This book is intended for intermediate JavaScript developers who are looking to enhance their understanding of single-page web application development with a focus on AngularJS and the JavaScript MVC frameworks.It is expected that readers will understand basic JavaScript patterns and idioms and can recognize JSON formatted data.

  20. CELLULAR DISTRIBUTION STUDIES OF THE NITRIC OXIDE-GENERATING ANTINEOPLASTIC PRODRUG JS-K, FORMULATED IN PLURONIC P123 MICELLES

    Science.gov (United States)

    Kaur, Imit; Terrazas, Moises; Kosak, Ken M.; Kern, Steven E.; Boucher, Kenneth M.; Shami, Paul J.

    2014-01-01

    Objective Nitric oxide (NO) possesses anti-tumor activity. It induces differentiation and apoptosis in acute myeloid leukemia (AML) cells. The NO prodrug O2-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate, or JS-K, has potent antileukemic activity. JS-K is also active in vitro and in vivo against multiple myeloma, prostate cancer, non-small cell lung cancer, glioma and liver cancer. Using the Pluronic® P123 polymer, we have developed a micelle formulation for JS-K in order to increase its solubility and stability. The goal of the current study was to investigate the cellular distribution of JS-K in AML cells. Methods We investigated the intracellular distribution of JS-K (free drug) and JS-K formulated in P123 micelles (P123/JS-K) using HL-60 AML cells. We also studied the S-glutathionylating effects of JS-K on proteins in the cytoplasmic and nuclear cellular fractions. Key findings Both free JS-K and P123/JS-K accumulate primarily in the nucleus. Both free JS-K and P123/JS-K induced S-glutathionylation of nuclear proteins, although the effect produced was more pronounced with P123/JS-K. Minimal S-glutathionylation of cytoplasmic proteins was observed. Conclusions We conclude that a micelle formulation of JS-K increases its accumulation in the nucleus. Post-translational protein modification through S-glutathionylation may contribute to JS-K’s anti-leukemic properties. PMID:23927471

  1. Research on TCP/IP network communication based on Node.js

    Science.gov (United States)

    Huang, Jing; Cai, Lixiong

    2018-04-01

    In the face of big data, long connection and high synchronization, TCP/IP network communication will cause performance bottlenecks due to its blocking multi-threading service model. This paper presents a method of TCP/IP network communication protocol based on Node.js. On the basis of analyzing the characteristics of Node.js architecture and asynchronous non-blocking I/O model, the principle of its efficiency is discussed, and then compare and analyze the network communication model of TCP/IP protocol to expound the reasons why TCP/IP protocol stack is widely used in network communication. Finally, according to the large data and high concurrency in the large-scale grape growing environment monitoring process, a TCP server design based on Node.js is completed. The results show that the example runs stably and efficiently.

  2. SATCHMO-JS: a webserver for simultaneous protein multiple sequence alignment and phylogenetic tree construction.

    Science.gov (United States)

    Hagopian, Raffi; Davidson, John R; Datta, Ruchira S; Samad, Bushra; Jarvis, Glen R; Sjölander, Kimmen

    2010-07-01

    We present the jump-start simultaneous alignment and tree construction using hidden Markov models (SATCHMO-JS) web server for simultaneous estimation of protein multiple sequence alignments (MSAs) and phylogenetic trees. The server takes as input a set of sequences in FASTA format, and outputs a phylogenetic tree and MSA; these can be viewed online or downloaded from the website. SATCHMO-JS is an extension of the SATCHMO algorithm, and employs a divide-and-conquer strategy to jump-start SATCHMO at a higher point in the phylogenetic tree, reducing the computational complexity of the progressive all-versus-all HMM-HMM scoring and alignment. Results on a benchmark dataset of 983 structurally aligned pairs from the PREFAB benchmark dataset show that SATCHMO-JS provides a statistically significant improvement in alignment accuracy over MUSCLE, Multiple Alignment using Fast Fourier Transform (MAFFT), ClustalW and the original SATCHMO algorithm. The SATCHMO-JS webserver is available at http://phylogenomics.berkeley.edu/satchmo-js. The datasets used in these experiments are available for download at http://phylogenomics.berkeley.edu/satchmo-js/supplementary/.

  3. BioJS: an open source JavaScript framework for biological data visualization.

    Science.gov (United States)

    Gómez, John; García, Leyla J; Salazar, Gustavo A; Villaveces, Jose; Gore, Swanand; García, Alexander; Martín, Maria J; Launay, Guillaume; Alcántara, Rafael; Del-Toro, Noemi; Dumousseau, Marine; Orchard, Sandra; Velankar, Sameer; Hermjakob, Henning; Zong, Chenggong; Ping, Peipei; Corpas, Manuel; Jiménez, Rafael C

    2013-04-15

    BioJS is an open-source project whose main objective is the visualization of biological data in JavaScript. BioJS provides an easy-to-use consistent framework for bioinformatics application programmers. It follows a community-driven standard specification that includes a collection of components purposely designed to require a very simple configuration and installation. In addition to the programming framework, BioJS provides a centralized repository of components available for reutilization by the bioinformatics community. http://code.google.com/p/biojs/. Supplementary data are available at Bioinformatics online.

  4. Instant IntroJs

    CERN Document Server

    Arasteh, Ehsan

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A simple starter that will guide you through IntroJs from scratch to advanced topics using a simple step by step approach with useful examples along the way.This book is for web designers who want to create an interactive step-by-step introduction for showing specific or all parts of an application or website to users. Basic JavaScript programming and knowledge of HTML and CSS is required. No knowledge of any other JavaScript libraries is needed

  5. Web-Based Geospatial Visualization of GPM Data with CesiumJS

    Science.gov (United States)

    Lammers, Matt

    2018-01-01

    Advancements in the capabilities of JavaScript frameworks and web browsing technology have made online visualization of large geospatial datasets such as those coming from precipitation satellites viable. These data benefit from being visualized on and above a three-dimensional surface. The open-source JavaScript framework CesiumJS (http://cesiumjs.org), developed by Analytical Graphics, Inc., leverages the WebGL protocol to do just that. This presentation will describe how CesiumJS has been used in three-dimensional visualization products developed as part of the NASA Precipitation Processing System (PPS) STORM data-order website. Existing methods of interacting with Global Precipitation Measurement (GPM) Mission data primarily focus on two-dimensional static images, whether displaying vertical slices or horizontal surface/height-level maps. These methods limit interactivity with the robust three-dimensional data coming from the GPM core satellite. Integrating the data with CesiumJS in a web-based user interface has allowed us to create the following products. We have linked with the data-order interface an on-the-fly visualization tool for any GPM/partner satellite orbit. A version of this tool also focuses on high-impact weather events. It enables viewing of combined radar and microwave-derived precipitation data on mobile devices and in a way that can be embedded into other websites. We also have used CesiumJS to visualize a method of integrating gridded precipitation data with modeled wind speeds that animates over time. Emphasis in the presentation will be placed on how a variety of technical methods were used to create these tools, and how the flexibility of the CesiumJS framework facilitates creative approaches to interact with the data.

  6. Genome Sequences of the Oxytetracycline Production Strain Streptomyces rimosus R6-500 and Two Mutants with Chromosomal Rearrangements

    KAUST Repository

    Baranasic, Damir

    2014-07-17

    The genome sequence of Streptomyces rimosus R6-500, an industrially improved strain which produces high titers of the important antibiotic oxytetracycline, is reported, as well as the genome sequences of two derivatives arising due to the genetic instability of the strain.

  7. Genome Sequences of the Oxytetracycline Production Strain Streptomyces rimosus R6-500 and Two Mutants with Chromosomal Rearrangements

    KAUST Repository

    Baranasic, Damir; Zucko, Jurica; Nair, Mridul; Pain, Arnab; Long, Paul F.; Hranueli, Daslav; Cullum, John; Starcevic, Antonio

    2014-01-01

    The genome sequence of Streptomyces rimosus R6-500, an industrially improved strain which produces high titers of the important antibiotic oxytetracycline, is reported, as well as the genome sequences of two derivatives arising due to the genetic instability of the strain.

  8. JS3P: junior staff programme pilot project

    International Nuclear Information System (INIS)

    Pretrel, H.; Tregoures, N.; Bessiron, V.; Dehoyos, A.; Delvallee, I.; Brisson, N.; Debayle, C.; Dubreuil, M.; Nicaise, G.; Perignon, J.P.; Richard, J.; Reinke, N.; Kaulard, J.; Burgener, M.; Keesmann, S.; Schramm, B.; Seubert, A.; Sternkopf, J.; Thuma, G.; Weber, S.; Smidts, O.; Maillet, E.; Bucalossi, A.; Van haesendonck, M.; Uyttenhove, W.; Mertens, J.

    2006-01-01

    Concept: The objective of the project is to allow junior staff members from the European Technical Safety Organisations (TSOs), IRSN, GRS and AVN, to work together with the final goal of creating a junior staff network, based on technical, cultural and personal interests. These projects are to show junior staff members at a very early stage during their career the need for European collaborations. They are also a tool to explore new subjects of co-operation. It is an initiative that should strengthen the links between the organisations and contribute to establishing the future of nuclear safety in Europe. A JS3P (Junior Staff Programme Pilot Project) is a project done jointly by 'junior' staff members from the three TSOs, where experience of 'seniors' is also integrated when needed. Compared to other collaborative activities, it has certain specific features. The JS3P favours staff exchanges, and technical meetings of several days should be planned during a project in order to encourage people to work together. Technical objectives are shared and the work is done jointly (reports, articles). The team involved in the JS3P should be as small as possible to favour its efficiency. The JS3P is short and easy to realize. Its duration is fixed to a maximum of about 12 months with the option to be prolonged. Typical topics are bibliographic work, comparison issues, scientific surveys, benchmark exercises and prospective investigations on innovative ideas. They can be linked to existing joint projects and then form a smaller module integrated into the large project. Topics may concern prospective issues, tentatively investigating new topics that can be seen as exploratory co-operation projects. Subjects may also concern research issues that are not a priority but that deserve to be investigated as new attractive topics. The JS3P is defined and managed by junior staff members. It is approved by a management board committee and supervised by a technical steering committee

  9. Juicebox.js Provides a Cloud-Based Visualization System for Hi-C Data.

    Science.gov (United States)

    Robinson, James T; Turner, Douglass; Durand, Neva C; Thorvaldsdóttir, Helga; Mesirov, Jill P; Aiden, Erez Lieberman

    2018-02-28

    Contact mapping experiments such as Hi-C explore how genomes fold in 3D. Here, we introduce Juicebox.js, a cloud-based web application for exploring the resulting datasets. Like the original Juicebox application, Juicebox.js allows users to zoom in and out of such datasets using an interface similar to Google Earth. Juicebox.js also has many features designed to facilitate data reproducibility and sharing. Furthermore, Juicebox.js encodes the exact state of the browser in a shareable URL. Creating a public browser for a new Hi-C dataset does not require coding and can be accomplished in under a minute. The web app also makes it possible to create interactive figures online that can complement or replace ordinary journal figures. When combined with Juicer, this makes the entire process of data analysis transparent, insofar as every step from raw reads to published figure is publicly available as open source code. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  10. JS-MS: a cross-platform, modular javascript viewer for mass spectrometry signals.

    Science.gov (United States)

    Rosen, Jebediah; Handy, Kyle; Gillan, André; Smith, Rob

    2017-11-06

    Despite the ubiquity of mass spectrometry (MS), data processing tools can be surprisingly limited. To date, there is no stand-alone, cross-platform 3-D visualizer for MS data. Available visualization toolkits require large libraries with multiple dependencies and are not well suited for custom MS data processing modules, such as MS storage systems or data processing algorithms. We present JS-MS, a 3-D, modular JavaScript client application for viewing MS data. JS-MS provides several advantages over existing MS viewers, such as a dependency-free, browser-based, one click, cross-platform install and better navigation interfaces. The client includes a modular Java backend with a novel streaming.mzML parser to demonstrate the API-based serving of MS data to the viewer. JS-MS enables custom MS data processing and evaluation by providing fast, 3-D visualization using improved navigation without dependencies. JS-MS is publicly available with a GPLv2 license at github.com/optimusmoose/jsms.

  11. JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells.

    Science.gov (United States)

    McMurtry, Vanity; Saavedra, Joseph E; Nieves-Alicea, René; Simeone, Ann-Marie; Keefer, Larry K; Tari, Ana M

    2011-04-01

    Targeted therapy with reduced side effects is a major goal in cancer research. We investigated the effects of JS-K, a nitric oxide (NO) prodrug designed to release high levels of NO when suitably activated, on human breast cancer cell lines, on non-transformed human MCF-10A mammary cells, and on normal human mammary epithelial cells (HMECs). Cell viability assay, flow cytometry, electron microscopy, and Western blot analysis were used to study the effects of JS-K on breast cancer and on mammary epithelial cells. After a 3-day incubation, the IC50s of JS-K against the breast cancer cells ranged from 0.8 to 3 µM. However, JS-K decreased the viability of the MCF-10A cells by only 20% at 10-µM concentration, and HMECs were unaffected by 10 µM JS-K. Flow cytometry indicated that JS-K increased the percentages of breast cancer cells under-going apoptosis. Interestingly, flow cytometry indicated that JS-K increased acidic vesicle organelle formation in breast cancer cells, suggesting that JS-K induced autophagy in breast cancer cells. Electron microscopy confirmed that JS-K-treated breast cancer cells underwent autophagic cell death. Western blot analysis showed that JS-K induced the expression of microtubule light chain 3-II, another autophagy marker, in breast cancer cells. However, JS-K did not induce apoptosis or autophagy in normal human mammary epithelial cells. These data indicate that JS-K selectively induces programmed cell death in breast cancer cells while sparing normal mammary epithelial cells under the same conditions. The selective anti-tumor activity of JS-K warrants its further investigation in breast tumors.

  12. Vcs.js - Visualization Control System for the Web

    Science.gov (United States)

    Chaudhary, A.; Lipsa, D.; Doutriaux, C.; Beezley, J. D.; Williams, D. N.; Fries, S.; Harris, M. B.

    2016-12-01

    VCS is a general purpose visualization library, optimized for climate data, which is part of the UV-CDAT system. It provides a Python API for drawing 2D plots such as lineplots, scatter plots, Taylor diagrams, data colored by scalar values, vector glyphs, isocontours and map projections. VCS is based on the VTK library. Vcs.js is the corresponding JavaScript API, designed to be as close as possible to the original VCS Python API and to provide similar functionality for the Web. Vcs.js includes additional functionality when compared with VCS. This additional API is used to introspect data files available on the server and variables available in a data file. Vcs.js can display plots in the browser window. It always works with a server that reads a data file, extracts variables from the file and subsets the data. From this point, two alternate paths are possible. First the system can render the data on the server using VCS producing an image which is send to the browser to be displayed. This path works for for all plot types and produces a reference image identical with the images produced by VCS. This path uses the VTK-Web library. As an optimization, usable in certain conditions, a second path is possible. Data is packed, and sent to the browser which uses a JavaScript plotting library, such as plotly, to display the data. Plots that work well in the browser are line-plots, scatter-plots for any data and many other plot types for small data and supported grid types. As web technology matures, more plots could be supported for rendering in the browser. Rendering can be done either on the client or on the server and we expect that the best place to render will change depending on the available web technology, data transfer costs, server management costs and value provided to users. We intend to provide a flexible solution that allows for both client and server side rendering and a meaningful way to choose between the two. We provide a web-based user interface called v

  13. JS-K, an arylating nitric oxide (NO) donor, has synergistic anti-leukemic activity with cytarabine (ARA-C).

    Science.gov (United States)

    Shami, Paul J; Maciag, Anna E; Eddington, Jordan K; Udupi, Vidya; Kosak, Ken M; Saavedra, Joseph E; Keefer, Larry K

    2009-11-01

    We have designed prodrugs that release nitric oxide (NO) on metabolism by glutathione S-transferases (GST). This design exploits the upregulation of GST in acute myeloid leukemia (AML) cells. O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K, a member of this class) has potent anti-leukemic activity. HL-60 myeloid leukemia cells were used for in vitro studies of the combination of JS-K with daunorubicin (DAUNO), cytarabine (ARA-C) or etoposide (ETOP) using the median effect method to determine synergistic, antagonistic, or additive effects. Combinations of JS-K added simultaneously, 2h before or 2h after the other compounds were used. JS-K and DAUNO were antagonistic in all three drug sequences. JS-K and ETOP were also antagonistic but to a lesser degree. JS-K and ARA-C showed strong synergy. The combination index at the 50% fraction affected was 0.37+/-0.23, 0.24+/-0.27, and 0.15+/-0.11 for simultaneous, JS-K first and ARA-C first additions, respectively. JS-K by itself induced DNA strand breaks at relatively high concentrations. However, at submicromolar concentrations, it significantly augmented ARA-C-induced DNA strand breaks. NMR spectroscopy revealed no evidence of chemical interaction between JS-K and the other chemotherapeutic agents. We conclude that ARA-C and JS-K have synergistic anti-leukemic activity and warrant further exploration in combination.

  14. Contrasting growth properties of Nocardioides JS614 on threedifferent vinyl halides.

    Science.gov (United States)

    Taylor, Anne E; Bottomley, Peter J; Semprini, Lewis

    2018-02-01

    Ethene (ETH)-grown inocula of Nocardioides JS614 grow on vinyl chloride (VC), vinyl fluoride (VF), or vinyl bromide (VB) as the sole carbon and energy source, with faster growth rates and higher cell yields on VC and VF than on VB. However, whereas acetate-grown inocula of JS614 grow on VC and VF after a lag period, growth on VB did not occur unless supplemental ethene oxide (EtO) was present in the medium. Despite inferior growth on VB, the maximum rate of VB consumption by ETH-grown cells was ~ 50% greater than the rates of VC and VF consumption, but Br - release during VB consumption was non-stoichiometric with VB consumption (~ 66%) compared to 100% release of Cl - and F - during VC and VF consumption. Evidence was obtained for VB turnover-dependent toxicity of cell metabolism in JS614 with both acetate-dependent respiration and growth being significantly reduced by VB turnover, but no VC or VF turnover-dependent toxicity of growth was detected. Reduced growth rate and cell yield of JS614 on VB probably resulted from a combination of inefficient metabolic processing of the highly unstable VB epoxide (t 0.5  = 45 s), accompanied by growth inhibitory effects of VB metabolites on acetate-dependent metabolism. The exact role(s) of EtO in promoting growth of alkene repressed JS614 on VB remains unresolved, with evidence of EtO inducing epoxide consuming activity prior to an increase in alkene oxidizing activity and supplementing reductant supply when VB is the growth substrate.

  15. Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells.

    Science.gov (United States)

    Liu, Jie; Malavya, Swati; Wang, Xueqian; Saavedra, Joseph E; Keefer, Larry K; Tokar, Erik; Qu, Wei; Waalkes, Michael P; Shami, Paul J

    2009-07-01

    The nitric oxide (NO) prodrug JS-K is shown to have anticancer activity. To profile the molecular events associated with the anticancer effects of JS-K, HL-60 leukemia cells were treated with JS-K and subjected to microarray and real-time RT-PCR analysis. JS-K induced concentration- and time-dependent gene expression changes in HL-60 cells corresponding to the cytolethality effects. The apoptotic genes (caspases, Bax, and TNF-alpha) were induced, and differentiation-related genes (CD14, ITGAM, and VIM) were increased. For acute phase protein genes, some were increased (TP53, JUN) while others were suppressed (c-myc, cyclin E). The expression of anti-angiogenesis genes THBS1 and CD36 and genes involved in tumor cell migration such as tissue inhibitors of metalloproteinases, were also increased by JS-K. Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug.

  16. Skoda JS's proposal for Slovak nuclear power industry

    International Nuclear Information System (INIS)

    Borovec, J.

    2004-01-01

    In this presentation author deals with the structure and revenues of the Skoda JS, a.s., as well as productions of the company for nuclear power industry in the Czech Republic, Ukraine and the Slovak Republic

  17. jsPsych: a JavaScript library for creating behavioral experiments in a Web browser.

    Science.gov (United States)

    de Leeuw, Joshua R

    2015-03-01

    Online experiments are growing in popularity, and the increasing sophistication of Web technology has made it possible to run complex behavioral experiments online using only a Web browser. Unlike with offline laboratory experiments, however, few tools exist to aid in the development of browser-based experiments. This makes the process of creating an experiment slow and challenging, particularly for researchers who lack a Web development background. This article introduces jsPsych, a JavaScript library for the development of Web-based experiments. jsPsych formalizes a way of describing experiments that is much simpler than writing the entire experiment from scratch. jsPsych then executes these descriptions automatically, handling the flow from one task to another. The jsPsych library is open-source and designed to be expanded by the research community. The project is available online at www.jspsych.org .

  18. phylo-node: A molecular phylogenetic toolkit using Node.js.

    Science.gov (United States)

    O'Halloran, Damien M

    2017-01-01

    Node.js is an open-source and cross-platform environment that provides a JavaScript codebase for back-end server-side applications. JavaScript has been used to develop very fast and user-friendly front-end tools for bioinformatic and phylogenetic analyses. However, no such toolkits are available using Node.js to conduct comprehensive molecular phylogenetic analysis. To address this problem, I have developed, phylo-node, which was developed using Node.js and provides a stable and scalable toolkit that allows the user to perform diverse molecular and phylogenetic tasks. phylo-node can execute the analysis and process the resulting outputs from a suite of software options that provides tools for read processing and genome alignment, sequence retrieval, multiple sequence alignment, primer design, evolutionary modeling, and phylogeny reconstruction. Furthermore, phylo-node enables the user to deploy server dependent applications, and also provides simple integration and interoperation with other Node modules and languages using Node inheritance patterns, and a customized piping module to support the production of diverse pipelines. phylo-node is open-source and freely available to all users without sign-up or login requirements. All source code and user guidelines are openly available at the GitHub repository: https://github.com/dohalloran/phylo-node.

  19. JS-K, a glutathione S-transferase-activated nitric oxide donor with antineoplastic activity in malignant gliomas.

    Science.gov (United States)

    Weyerbrock, Astrid; Osterberg, Nadja; Psarras, Nikolaos; Baumer, Brunhilde; Kogias, Evangelos; Werres, Anna; Bette, Stefanie; Saavedra, Joseph E; Keefer, Larry K; Papazoglou, Anna

    2012-02-01

    Glutathione S-transferases (GSTs) control multidrug resistance and are upregulated in many cancers, including malignant gliomas. The diazeniumdiolate JS-K generates nitric oxide (NO) on enzymatic activation by glutathione and GST, showing promising NO-based anticancer efficacy. To evaluate the role of NO-based antitumor therapy with JS-K in U87 gliomas in vitro and in vivo. U87 glioma cells and primary glioblastoma cell lines were exposed to JS-K and a variety of inhibitors to study cell death by necrosis, apoptosis, and other mechanisms. GST expression was evaluated by immunocytochemistry, polymerase chain reaction, and Western blot, and NO release from JS-K was studied with a NO assay. The growth-inhibitory effect of JS-K was studied in a U87 xenograft model in vivo. Dose-dependent inhibition of cell proliferation was observed in human U87 glioma cells and primary glioblastoma cells in vitro. Cell death was partially induced by caspase-dependent apoptosis, which could be blocked by Z-VAD-FMK and Q-VD-OPH. Inhibition of GST by sulfasalazine, cGMP inhibition by ODQ, and MEK1/2 inhibition by UO126 attenuated the antiproliferative effect of JS-K, suggesting the involvement of various intracellular death signaling pathways. Response to JS-K correlated with mRNA and protein expression of GST and the amount of NO released by the glioma cells. Growth of U87 xenografts was reduced significantly, with immunohistochemical evidence for increased necrosis and apoptosis and reduced proliferation. Our data show for the first time the potent antiproliferative effect of JS-K in gliomas in vitro and in vivo. These findings warrant further investigation of this novel NO-releasing prodrug in gliomas.

  20. A reactive oxygen species activation mechanism contributes to JS-K-induced apoptosis in human bladder cancer cells.

    Science.gov (United States)

    Qiu, Mingning; Chen, Lieqian; Tan, Guobin; Ke, Longzhi; Zhang, Sai; Chen, Hege; Liu, Jianjun

    2015-10-13

    Reactive oxygen species (ROS) and cellular oxidant stress are regulators of cancer cells. The alteration of redox status, which is induced by increased generation of ROS, results in increased vulnerability to oxidative stress. The aim of this study is to investigate the influence of O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K, C13H16N6O8) on proliferation and apoptosis in bladder cancer cells and explored possible ROS-related mechanisms. Our results indicated that JS-K could suppress bladder cancer cell proliferation in a concentration- and time-dependent manner and induce apoptosis and ROS accumulation in a concentration-dependent manner. With increasing concentrations of JS-K, expression of proteins that are involved in cell apoptosis increased in a concentration-dependent manner. Additionally, the antioxidant N-acetylcysteine (NAC) reversed JS-K-induced cell apoptosis; conversely, the prooxidant oxidized glutathione (GSSG) exacerbated JS-K-induced cell apoptosis. Furthermore, we found that nitrites, which were generated from the oxidation of JS-K-released NO, induced apoptosis in bladder cancer cells to a lower extent through the ROS-related pathway. In addition, JS-K was shown to enhance the chemo-sensitivity of doxorubicin in bladder cancer cells. Taken together, the data suggest that JS-K-released NO induces bladder cancer cell apoptosis by increasing ROS levels, and nitrites resulting from oxidation of NO have a continuous apoptosis-inducing effect.

  1. pileup.js: a JavaScript library for interactive and in-browser visualization of genomic data.

    Science.gov (United States)

    Vanderkam, Dan; Aksoy, B Arman; Hodes, Isaac; Perrone, Jaclyn; Hammerbacher, Jeff

    2016-08-01

    P: ileup.js is a new browser-based genome viewer. It is designed to facilitate the investigation of evidence for genomic variants within larger web applications. It takes advantage of recent developments in the JavaScript ecosystem to provide a modular, reliable and easily embedded library. The code and documentation for pileup.js is publicly available at https://github.com/hammerlab/pileup.js under the Apache 2.0 license. correspondence@hammerlab.org. © The Author 2016. Published by Oxford University Press.

  2. JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells.

    Science.gov (United States)

    Udupi, Vidya; Yu, Margaret; Malaviya, Swati; Saavedra, Joseph E; Shami, Paul J

    2006-10-01

    Nitric oxide (NO) induces differentiation and apoptosis in acute myelogenous leukemia (AML) cells. The NO prodrug O2-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate, or JS-K, has potent antileukemic activity. JS-K induces apoptosis in HL-60 cells by a caspase-dependent mechanism. The purpose of this study was to determine the pathway through which JS-K induces apoptosis. We show that JS-K alters mitochondrial membrane potential (DeltaPsim) and induces cytochrome c release from mitochondria into the cytoplasm. Treatment with JS-K resulted in activation of Caspase (Casp) 9, Casp 3 and Casp 8. JS-K constitutes a promising lead for a new class of anti-leukemic agents.

  3. The nitric oxide prodrug JS-K and its structural analogues as cancer therapeutic agents.

    Science.gov (United States)

    Maciag, Anna E; Saavedra, Joseph E; Chakrapani, Harinath

    2009-09-01

    Nitric oxide (NO) prodrugs of the diazeniumdiolate class are routinely used as reliable sources of nitric oxide in chemical and biological laboratory settings. O(2)-(2,4-dinitrophenyl) diazeniumdiolates, which are derivatized forms of ionic diazeniumdiolates, have been found to show potent anti-proliferative activity in a variety of cancer cells, presumably through the effects of NO. One important member of this class of diazeniumdiolates, O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), has shown promise as a novel cancer therapeutic agent in a number of animal models. This review describes the developments in chemical and biochemical characterization and structure-activity relationship of JS-K and its analogues. In addition, some molecular mechanistic insights into the observed anti-proliferative activity of JS-K are discussed. Finally, a structural motif is presented for O(2)-(aryl) diazeniumdiolate nitric oxide prodrugs that show potency comparable with that of JS-K.

  4. JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells.

    Science.gov (United States)

    Tan, Guobin; Qiu, Mingning; Chen, Lieqian; Zhang, Sai; Ke, Longzhi; Liu, Jianjun

    2017-05-26

    In view of the fact that JS-K might regulate ubiquitin E3 ligase and that ubiquitin E3 ligase plays an important role in the mechanism of CRPC formation, the goal was to investigate the probable mechanism by which JS-K regulates prostate cancer cells. Proliferation inhibition by JS-K on prostate cancer cells was examined usingCCK-8 assays. Caspase 3/7 activity assays and flow cytometry were performed to examine whether JS-K induced apoptosis in prostate cancer cells. Western blotting and co-immunoprecipitation analyses investigated JS-K's effects on the associated apoptosis mechanism. Real time-PCR and Western blotting were performed to assess JS-K's effect on transcription of specific AR target genes. Western blotting was also performed to detect Siah2 and AR protein concentrations and co-immunoprecipitation to detect interactions of Siah2 and AR, NCoR1 and AR, and p300 and AR. JS-K inhibited proliferation and induced apoptosis in prostate cancer cells. JS-K increased p53 and Mdm2 concentrations and regulated the caspase cascade reaction-associated protein concentrations. JS-K inhibited transcription of AR target genes and down-regulated PSA protein concentrations. JS-K inhibited Siah2 interactions and also inhibited the ubiquitination of AR. With further investigation, JS-K was found to stabilize AR and NCoR1 interactions and diminish AR and p300 interactions. The present results suggested that JS-K might have been able to inhibit proliferation and induce apoptosis via regulation of the ubiquitin-proteasome degradation pathway, which represented a promising platform for the development of new compounds for PCa treatments.

  5. Web development with MongoDB and Node.js

    CERN Document Server

    Krol, Jason

    2014-01-01

    This book is designed for developers of any skill level that want to get up and running using Node.js and MongoDB to build full featured web applications. A basic understanding of JavaScript and HTML is the only requirement for this book.

  6. Effects of JS-K, a novel anti-cancer nitric oxide prodrug, on gene expression in human hepatoma Hep3B cells.

    Science.gov (United States)

    Dong, Ray; Wang, Xueqian; Wang, Huan; Liu, Zhengyun; Liu, Jie; Saavedra, Joseph E

    2017-04-01

    JS-K is a novel anticancer nitric oxide (NO) prodrug effective against a variety of cancer cells, including the inhibition of AM-1 hepatoma cell growth in rats. To further evaluate anticancer effects of JS-K, human hepatoma Hep3B cells were treated with JS-K and the compound control JS-43-126 at various concentrations (0-100μM) for 24h, and cytotoxicity was determined by the MTS assay. The compound control JS-43-126 was not cytotoxic to Hep3B cells at concentrations up to 100μM, while the LC 50 for JS-K was about 10μM. To examine the molecular mechanisms of antitumor effects of JS-K, Hep3B cells were treated with 1-10μM of JS-K for 24h, and then subjected to gene expression analysis via real time RT-PCR and protein immunostain via confocal images. JS-K is a GST-α targeting NO prodrug, and decreased immunostaining for GST-α was associated with JS-K treatment. JS-K activated apoptosis pathways in Hep3B cells, including induction of caspase-3, caspase-9, Bax, TNF-α, and IL-1β, and immunostaining for caspase-3 was intensified. The expressions of thrombospondin-1 (TSP-1) and the tissue inhibitors of metalloproteinase-1 (TIMP-1) were increased by JS-K at both transcript and protein levels. JS-K treatment also increased the expression of differentiation-related genes CD14 and CD11b, and depressed the expression of c-myc in Hep3B cells. Thus, multiple molecular events appear to be associated with anticancer effects of JS-K in human hepatoma Hep3B cells, including activation of genes related to apoptosis and induction of genes involved in antiangiogenesis and tumor cell migration. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  7. The nitric oxide donor JS-K sensitizes U87 glioma cells to repetitive irradiation.

    Science.gov (United States)

    Heckler, Max; Osterberg, Nadja; Guenzle, Jessica; Thiede-Stan, Nina Kristin; Reichardt, Wilfried; Weidensteiner, Claudia; Saavedra, Joseph E; Weyerbrock, Astrid

    2017-06-01

    As a potent radiosensitizer nitric oxide (NO) may be a putative adjuvant in the treatment of malignant gliomas which are known for their radio- and chemoresistance. The NO donor prodrug JS-K (O2-(2.4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1,2-diolate) allows cell-type specific intracellular NO release via enzymatic activation by glutathione-S-transferases overexpressed in glioblastoma multiforme. The cytotoxic and radiosensitizing efficacy of JS-K was assessed in U87 glioma cells in vitro focusing on cell proliferation, induction of DNA damage, and cell death. In vivo efficacy of JS-K and repetitive irradiation were investigated in an orthotopic U87 xenograft model in mice. For the first time, we could show that JS-K acts as a potent cytotoxic and radiosensitizing agent in U87 cells in vitro. This dose- and time-dependent effect is due to an enhanced induction of DNA double-strand breaks leading to mitotic catastrophe as the dominant form of cell death. However, this potent cytotoxic and radiosensitizing effect could not be confirmed in an intracranial U87 xenograft model, possibly due to insufficient delivery into the brain. Although NO donor treatment was well tolerated, neither a retardation of tumor growth nor an extended survival could be observed after JS-K and/or radiotherapy.

  8. RESTful web API design with Node.js

    CERN Document Server

    Bojinov, Valentin

    2015-01-01

    If you are a web developer wanting to enrich your development skills to create scalable, server-side, RESTful applications based on the Node.js platform, this book is for you. You also need to be aware of HTTP communication concepts and should have a working knowledge of JavaScript. Knowledge of REST would be an added advantage but is definitely not a necessity.

  9. Hydrolysis and photolysis of diacylhydrazines-type insect growth regulator JS-118 in aqueous solutions under abiotic conditions.

    Science.gov (United States)

    Hu, J-Y; Liu, C; Zhang, Y-C; Zheng, Z-X

    2009-05-01

    JS-118 is a diacylhydrazines-type insect growth regulator which is now used extensively in China. The hydrolysis and photolysis of the pesticide JS-118 in aqueous solutions have been assessed under natural and controlled conditions in this project. Hydrolysis experimental results show that JS-118 is quite stable in aqueous solutions in dark, with no significant variations be observed in degradation under various conditions. Abiotic hydrolysis is relatively unimportant compared to photolysis. The rate of photodecomposition of JS-118 in aqueous solutions follows first-order kinetics both in UV radiation and natural sunlight. The degradation rates are faster under UV light than sunlight, with the half-lives (t (1/2) = ln2/k) of 6.00-10.85 min and 6.63-10.16 day, respectively. Under UV light, two major photoproducts are detected, and tentatively identified according to HPLC-MS spectral information as N-t-butyl-N-(3,5-dimethylbenzoyl) and 3,7-dimethyl-benzoatedihydrofuran. The corresponding photolysis pathways of JS-118 are also proposed. The results obtained indicate that direct photoreaction is an important dissipation pathway of JS-118 in natural water systems.

  10. Getting started with PhantomJS

    CERN Document Server

    Beltran, Aries

    2013-01-01

    The book will follow aA standard tutorial approach, and will beas a complete guide detailing the major aspects of PhantomJS with particular focus on Website website Testingtesting.This book is written forIf you are a JavaScript developers who are is interested in developing applications that interact with various web services, and doing that using a headless browser, then this book is ideal for you. This book iswill also be good for you if you are planning to create a headless browser testing for your web application. Basic understanding of JavaScript is assumed.

  11. Instant Backbone.js application development

    CERN Document Server

    Hunter, Thomas

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is a practical, step-by-step tutorial that will teach you to build Backbone.js applications quickly and efficiently.This book is targeted towards developers. It is assumed that you have at least a basic understanding of JavaScript and jQuery selectors. If you are interested in building dynamic Single Page Applications that interact heavily with a backend server, then this is the book for you.

  12. The Nitric Oxide Prodrug JS-K Induces Ca(2+)-Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.

    Science.gov (United States)

    Liu, Ling; Wang, Dongmei; Wang, Jiangang; Wang, Shuying

    2016-04-01

    Hepatocellular carcinoma is one of the most common and deadly forms of human malignancies. JS-K, O(2)-(2, 4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1, 2-diolate, has the ability to induce apoptosis of tumor cell lines. In the present study, JS-K inhibited the proliferation of HepG2 cells in a time- and concentration-dependent manner and significantly induced apoptosis. JS-K enhanced the ratio of Bax-to-Bcl-2, released of cytochrome c (Cyt c) from mitochondria and the activated caspase-9/3. JS-K caused an increasing cytosolic Ca(2+) and the loss of mitochondrial membrane potential. Carboxy-PTIO (a NO scavenger) and BAPTA-AM (an intracellular Ca(2+) chelator) significantly blocked an increasing cytosolic Ca(2+) in JS-K-induced HepG2 cells apoptosis, especially Carboxy-PTIO. Meanwhile, Carboxy-PTIO and BAPTA-AM treatment both attenuate JS-K-induced apoptosis through upregulation of Bcl-2, downregulation of Bax, reduction of Cyt c release from mitochondria to cytoplasm and inactivation of caspase-9/3. In summary, JS-K induced HepG2 cells apoptosis via Ca(2+)/caspase-3-mediated mitochondrial pathway. © 2015 Wiley Periodicals, Inc.

  13. Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells.

    Science.gov (United States)

    Kaczmarek, Monika Z; Holland, Ryan J; Lavanier, Stephen A; Troxler, Jami A; Fesenkova, Valentyna I; Hanson, Charlotte A; Cmarik, Joan L; Saavedra, Joseph E; Keefer, Larry K; Ruscetti, Sandra K

    2014-03-01

    The nitric oxide (NO) prodrug JS-K, a promising anti-cancer agent, consists of a diazeniumdiolate group necessary for the release of NO as well as an arylating ring. In this study, we research the mechanism by which JS-K kills a murine erythroleukemia cell line and determine the roles of NO and arylation in the process. Our studies indicate that JS-K inhibits the PI 3-kinase/Akt and MAP kinase pathways. This correlates with the activation of the tumor suppressor FoxO3a and increased expression of various caspases, leading to apoptosis. The arylating capability of JS-K appears to be sufficient for inducing these biological effects. Overall, these data suggest that JS-K kills tumor cells by arylating and inactivating signaling molecules that block the activation of a tumor suppressor. Published by Elsevier Ltd.

  14. Instant dependency management with RequireJS how-to

    CERN Document Server

    Franko, Greg

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks.A concise guide that delivers immediate results with practical recipes on customizing your projects.This book is for intermediate to advanced JavaScript developers who are interested in learning more about AMD specification and RequireJS.

  15. Unit testing of AngularJS : A look into writing tests for web application

    OpenAIRE

    Karttunen, Joel

    2016-01-01

    This task was assigned by Protacon Solutions Oy with the objective set to study and implement unit testing in AngularJS JavaScript framework as part of the development process of the customer’s application. The thesis focuses on studying the AngularJS framework and if and how its design philosophy complements the unit testing principles. The focus was on studying unit testing via developing unit tests iteratively onto the application created beforehand. The tests were created with Jas...

  16. Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53.

    Science.gov (United States)

    Kitagaki, J; Yang, Y; Saavedra, J E; Colburn, N H; Keefer, L K; Perantoni, A O

    2009-01-29

    Nitric oxide (NO) is a major effector molecule in cancer prevention. A number of studies have shown that NO prodrug JS-K (O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) induces apoptotic cell death in vitro and in vivo, indicating that it is a promising new therapeutic for cancer. However, the mechanism of its tumor-killing activity remains unclear. Ubiquitin plays an important role in the regulation of tumorigenesis and cell apoptosis. Our earlier report has shown that inactivation of the ubiquitin system through blocking E1 (ubiquitin-activating enzyme) activity preferentially induces apoptosis in p53-expressing transformed cells. As E1 has an active cysteine residue that could potentially interact with NO, we hypothesized that JS-K could inactivate E1 activity. E1 activity was evaluated by detecting ubiquitin-E1 conjugates through immunoblotting. JS-K strikingly inhibits the ubiquitin-E1 thioester formation in cells in a dose-dependent manner with an IC(50) of approximately 2 microM, whereas a JS-K analog that cannot release NO did not affect these levels in cells. Moreover, JS-K decreases total ubiquitylated proteins and increases p53 levels, which is mainly regulated by ubiquitin and proteasomal degradation. Furthermore, JS-K preferentially induces cell apoptosis in p53-expressing transformed cells. These findings indicate that JS-K inhibits E1 activity and kills transformed cells harboring wild-type p53.

  17. JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38.

    Science.gov (United States)

    Yi, Young-Su; Kim, Mi-Yeon; Cho, Jae Youl

    2017-05-01

    Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophage-mediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) and down-regulated the mRNA expression of the inflammatory enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as the expression of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-1b without cytotoxicity in LPS-stimulated RAW264.7 cells. JS-III-49 inhibited nuclear translocation of the NF-kB transcription factors p65 and p50 by directly targeting Akt, an upstream kinase of the NF-kB pathway, in LPS-stimulated RAW264.7 cells. However, JS-III-49 did not directly inhibit the kinase activities of Src and Syk, which are upstream kinases of Akt, in LPS-stimulated RAW264.7 cells. Moreover, JS-III-49 suppressed the nuclear translocation of c-Fos, one of the components of AP-1, by specifically targeting p38, an upstream mitogen-activated protein kinase (MAPK) in the AP-1 pathway in LPS-stimulated RAW264.7 cells. These results suggest that JS-III-49 plays an anti-inflammatory role in LPS-stimulated macrophages by targeting Akt and p38 in the NF-kB and AP-1 pathways, respectively.

  18. BioCircos.js: an interactive Circos JavaScript library for biological data visualization on web applications.

    Science.gov (United States)

    Cui, Ya; Chen, Xiaowei; Luo, Huaxia; Fan, Zhen; Luo, Jianjun; He, Shunmin; Yue, Haiyan; Zhang, Peng; Chen, Runsheng

    2016-06-01

    We here present BioCircos.js, an interactive and lightweight JavaScript library especially for biological data interactive visualization. BioCircos.js facilitates the development of web-based applications for circular visualization of various biological data, such as genomic features, genetic variations, gene expression and biomolecular interactions. BioCircos.js and its manual are freely available online at http://bioinfo.ibp.ac.cn/biocircos/ rschen@ibp.ac.cn Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Summary of Skoda JS rod drop measurements analysis

    International Nuclear Information System (INIS)

    Svarny, J.; Krysl, V.

    1999-01-01

    A summary is presented of the Skoda JS rod drop reactivity measurements analysis provided during last two years based on control rod worth measurements by the outer ion chambers. Standard analysis based on comparisons of dynamics macrocode MOBY-DICK-SK and experimental data is extended to the 8-th group delayed neutron structure and new features of rod drop process are investigated. (author)

  20. JS-K has Potent Anti-Angiogenic Activity in vitro and Inhibits Tumor Angiogenesis in a Multiple Myeloma Model in vivo

    Science.gov (United States)

    Kaur, Gurmeet; Kiziltepe, Tanyel; Anderson, Kenneth C.; Kutok, Jeffery L.; Jia, Lee; Boucher, Kenneth M.; Saavedra, Joseph E.; Keefer, Larry K.; Shami, Paul J.

    2009-01-01

    Glutathione S-Transferases (GST) play an important role in multidrug resistance and are upregulated in multiple cancers. We have designed a prodrug class that releases NO on metabolism by GST. O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K, a member of this class) has potent anti-neoplastic activity. We studied the effect of JS-K on angiogenesis. JS-K inhibited the proliferation of HUVEC’s with a 50% inhibitory concentration (IC50) of 0.432, 0.466, and 0.505 µM at 24, 48, and 72 hours, respectively. In the cord formation assay, JS-K led to a decrease in the number of cord junctions and cord length with an IC50 of 0.637 and 0.696 µM, respectively. JS-K inhibited cell migration at 5 hours using VEGF as a chemoattractant. Migration inhibition occurred with an IC50 of 0.493 µM. In the chick aortic ring assay using VEGF or FGF-b for vessel growth stimulation, 0.5 µM JS-K completely inhibited vessel growth. JS-K inhibited tumor angiogenesis in vivo in NIH III mice implanted subcutaneously with OPM1 multiple myeloma cells. JS-K is a potent inhibitor of angiogenesis in vitro and tumor vessel growth in vivo. As such, it establishes a new class of anti-neoplastic agents that target the malignant cells directly as well as their microenvironment. PMID:20723011

  1. Studies on Nitrobenzene Metabolism by a Comamonas sp. Strain JS7651

    National Research Council Canada - National Science Library

    Gibson, David

    2000-01-01

    .... The nitrobenzene dioxygenase enzyme system shares high amino acid homology with other identified nitroarene dioxygenase enzymes, in particular the 2-nitrotoluene dioxygenase system from Pseudomonas sp. strain JS42...

  2. Activation of Pathogenesis-related Genes by the Rhizobacterium, Bacillus sp. JS, Which Induces Systemic Resistance in Tobacco Plants.

    Science.gov (United States)

    Kim, Ji-Seong; Lee, Jeongeun; Lee, Chan-Hui; Woo, Su Young; Kang, Hoduck; Seo, Sang-Gyu; Kim, Sun-Hyung

    2015-06-01

    Plant growth promoting rhizobacteria (PGPR) are known to confer disease resistance to plants. Bacillus sp. JS demonstrated antifungal activities against five fungal pathogens in in vitro assays. To verify whether the volatiles of Bacillus sp. JS confer disease resistance, tobacco leaves pre-treated with the volatiles were damaged by the fungal pathogen, Rhizoctonia solani and oomycete Phytophthora nicotianae. Pre-treated tobacco leaves had smaller lesion than the control plant leaves. In pathogenesis-related (PR) gene expression analysis, volatiles of Bacillus sp. JS caused the up-regulation of PR-2 encoding β-1,3-glucanase and acidic PR-3 encoding chitinase. Expression of acidic PR-4 encoding chitinase and acidic PR-9 encoding peroxidase increased gradually after exposure of the volatiles to Bacillus sp. JS. Basic PR-14 encoding lipid transfer protein was also increased. However, PR-1 genes, as markers of salicylic acid (SA) induced resistance, were not expressed. These results suggested that the volatiles of Bacillus sp. JS confer disease resistance against fungal and oomycete pathogens through PR genes expression.

  3. PhoneGap and AngularJS for cross-platform development

    CERN Document Server

    Liang, Yuxian Eugene

    2014-01-01

    This book is intended for people who are not familiar with AngularJS and who want to take their PhoneGap development skills further by developing apps using different JavaScript libraries. People with some knowledge of PhoneGap, HTML, CSS, and JavaScript will find this book immediately useful.

  4. JS-K has potent anti-angiogenic activity in vitro and inhibits tumour angiogenesis in a multiple myeloma model in vivo.

    Science.gov (United States)

    Kiziltepe, Tanyel; Anderson, Kenneth C; Kutok, Jeffery L; Jia, Lee; Boucher, Kenneth M; Saavedra, Joseph E; Keefer, Larry K; Shami, Paul J

    2010-01-01

    Glutathione S-transferases (GSTs) play an important role in multidrug resistance and are upregulated in multiple cancers. We have designed a prodrug class that releases nitric oxide on metabolism by GST. O(2)-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K, a member of this class) has potent antineoplastic activity. We studied the effect of JS-K on angiogenesis in human umbilical vein endothelial cells (HUVECs), OPM1 multiple myeloma cells, chick aortic rings and in mice. JS-K inhibited the proliferation of HUVECs with a 50% inhibitory concentration (IC50) of 0.432, 0.466 and 0.505 microm at 24, 48 and 72 h, respectively. In the cord formation assay, JS-K led to a decrease in the number of cord junctions and cord length with an IC50 of 0.637 and 0.696 microm, respectively. JS-K inhibited cell migration at 5 h using VEGF as a chemoattractant. Migration inhibition occurred with an IC50 of 0.493 microm. In the chick aortic ring assay using VEGF or FGF-2 for vessel growth stimulation, 0.5 microm JS-K completely inhibited vessel growth. JS-K inhibited tumour angiogenesis in vivo in NIH III mice implanted subcutaneously with OPM1 multiple myeloma cells. JS-K is a potent inhibitor of angiogenesis in vitro and tumour vessel growth in vivo. As such, it establishes a new class of antineoplastic agent that targets the malignant cells directly as well as their microenvironment.

  5. Physiological and proteomic analysis of plant growth enhancement by the rhizobacteria Bacillus sp. JS.

    Science.gov (United States)

    Kim, Ji Seong; Lee, Jeong Eun; Nie, Hualin; Lee, Yong Jae; Kim, Sun Tae; Kim, Sun-Hyung

    2018-02-01

    In this study, the effects of the plant growth-promoting rhizobacterium (PGPR), Bacillus sp. JS on the growth of tobacco (Nicotiana tabacum 'Xanthi') and lettuce (Lactuca sativa 'Crispa'), were evaluated by comparing various growth parameters between plants treated with the bacterium and those exposed to water or nutrient broth as control. In both tobacco and lettuce, fresh weight and length of shoots were increased upon exposure to Bacillus sp. JS. To explain the overall de novo expression of plant proteins by bacterial volatiles, two-dimensional gel electrophoresis was performed on samples from PGPR-treated tobacco plants. Our results showed that chlorophyll a/b binding proteins were significantly up-regulated, and total chlorophyll content was also increased. Our findings indicate the potential benefits of using Bacillus sp. JS as a growth-promoting factor in agricultural practice, and highlight the need for further research to explore these benefits.

  6. Introduktion til programmering (P5/JS) light version 1.0

    DEFF Research Database (Denmark)

    Bjerre, Anne

    2015-01-01

    Undervisningsmateriale til begynderprogrammering. Materialet er baseret på P5, som er et grafisk baseret Javascript-bibliotek. Applikationen er en "light"-udgave af Introduktion til programmering (P5/JS) version 1.0. Afsnittet om transformationer er udeladt, og resten af applikationen modificeret...

  7. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils.

    Science.gov (United States)

    Liu, Min-Yu; Xiao, Lin; Chen, Geng-Hui; Wang, Yong-Xiang; Xiong, Wei-Xia; Li, Fei; Liu, Ying; Huang, Xiao-Ling; Deng, Yi-Fang; Zhang, Zhen; Sun, Hai-Yan; Liu, Quan-Hai; Yin, Ming

    2014-10-01

    JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY human hepatoma in nude mice. The anti-tumor interactions of JS-38 and cyclophosphamide (CTX) or 5-fluorouracil (5-Fu) were studied in a S180 sarcoma model in ICR mice. Specific stimulatory effects were determined on peripheral neutrophils in normal and CTX- and 5-Fu-induced neutropenic mice. The IC50 values ranged from 0.1 to 2.0 μmol·L(-1). JS-38 (1 μmol·L(-1)) caused an increase in A549 tumor cell apoptosis. Multi-daily gavage of JS-38 (15, 30, and 60 mg·kg(-1)·d(-1)) inhibited in vivo tumor progression without a significant effect on body weight. JS-38 additively enhanced the in vivo anti-tumor effects of CTX or 5-Fu. JS-38 increased peripheral neutrophil counts and neutrophil rates in normal BALB/c mice almost as effectively as granulocyte colony-stimulating factor (G-CSF). In mice with neutropenia induced by CTX or 5-Fu, JS-38 rapidly restored neutrophil counts. These results suggest that JS-38 has anti-tumor activity, and also has the ability to increase peripheral blood neutrophils. Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  8. Variations in glycoprotein B contribute to immunogenic difference between PRV variant JS-2012 and Bartha-K61.

    Science.gov (United States)

    Yu, Zhi-Qing; Tong, Wu; Zheng, Hao; Li, Li-Wei; Li, Guo-Xin; Gao, Fei; Wang, Tao; Liang, Chao; Ye, Chao; Wu, Ji-Qiang; Huang, Qinfeng; Tong, Guang-Zhi

    2017-09-01

    A newly emerged pseudorabies virus (PRV) variant has been identified in many Bartha-K61-vaccinated pig farms. This variant has caused great economic losses to the swine industry in China since 2011. Sequence analysis demonstrated that the gB gene of the emerging PRV variant JS-2012 had multiple variations compared with the vaccine strain Bartha-K61. In the study, a specific CRISPR/Cas9 system combined with homologous recombination was used to construct two recombinant viruses, BJB (Bartha-K61+JS-2012gB) and JBJ (JS-2012-ΔgE/gI+Bartha-K61gB), by interchanging the full-length gB genes between Bartha-K61 and JS-2012-ΔgE/gI. The two recombinant viruses showed similar characteristics in growth kinetics in vitro and similar pathogenicity in mice, as compared to their parental strains. Immunization of mice with inactivated BJB or JBJ followed by challenge of JS-2012 showed that BJB could increase protective efficacy to 80%, compared to only 40% protection by the parental Bartha-K61 strain. JBJ had a decreased protective efficacy of 65%, as compared to 90% protection by its parental JS-2012-ΔgE/gI strain. Exchange of the gB gene markedly altered the immunogenicity of the recombinant PRV. These data suggest that variations in gB might play an important role in the virulence of the reemergent PRV variant in China. Our results demonstrate the importance of gB in protective immunity and suggest that the recombinant virus BJB could be a promising vaccine candidate for eradication of the PRV variant. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. A live, attenuated pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains.

    Science.gov (United States)

    Tong, Wu; Li, Guoxin; Liang, Chao; Liu, Fei; Tian, Qing; Cao, Yanyun; Li, Lin; Zheng, Xuchen; Zheng, Hao; Tong, Guangzhi

    2016-06-01

    Emerging pseudorabies virus (PRV) variant have led to pseudorabies outbreaks in Chinese pig farms. The commercially available PRV vaccine provides poor protection against the PRV variant. In this study, a gE/gI deleted PRV strain JS-2012-△gE/gI was generated from a PRV variant strain using homologous DNA recombination. Compared to the parental strain JS-2012, JS-2012-△gE/gI grew slowly and showed small plaque morphology on Vero cells. The safety and immunological efficacy of JS-2012-△gE/gI was evaluated as a vaccine candidate. JS-2012-△gE/gI was avirulent to suckling piglets, but was able to provide full protection for young piglets against challenge with both the classical virulent PRV and the emerging PRV variant. After sows were vaccinated with the gE/gI-deleted strain, their suckling offspring were resistant to an otherwise lethal challenge with the classical and the variant PRVs. Piglets inoculated with JS-2012-△gE/gI did not develop PRV-specific gE-ELISA antibodies. Thus, JS-2012-△gE/gI appears to be a promising marker vaccine candidate to control PRV variant circulating in pig farms in China. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Tumor metastatizado después de la radiación

    OpenAIRE

    Iglesias Rozas, José Rafael, 1942-

    1986-01-01

    Dos imágenes de un tumor metastatizado después de someterse a radiación en un paciente de 49 años. Two pictures of an metastasized tumor after it has gone through irradiation in a 49-year-old male patient.

  11. Isolation and characterization of butachlor-catabolizing bacterial strain Stenotrophomonas acidaminiphila JS-1 from soil and assessment of its biodegradation potential.

    Science.gov (United States)

    Dwivedi, S; Singh, B R; Al-Khedhairy, A A; Alarifi, S; Musarrat, J

    2010-07-01

    Isolation, characterization and assessment of butachlor-degrading potential of bacterial strain JS-1 in soil. Butachlor-degrading bacteria were isolated using enrichment culture technique. The morphological, biochemical and genetic characteristics based on 16S rDNA sequence homology and phylogenetic analysis confirmed the isolate as Stenotrophomonas acidaminiphila strain JS-1. The strain JS-1 exhibited substantial growth in M9 mineral salt medium supplemented with 3.2 mmol l(-1) butachlor, as a sole source of carbon and energy. The HPLC analysis revealed almost complete disappearance of butachlor within 20 days in soil at a rate constant of 0.17 day(-1) and half-life (t((1/2))) of 4.0 days, following the first-order rate kinetics. The strain JS-1 in stationary phase of culture also produced 21.0 microg ml(-1) of growth hormone indole acetic acid (IAA) in the presence of 500 microg ml(-1) of tryptophan. The IAA production was stimulated at lower concentrations of butachlor, whereas higher concentrations above 0.8 mmol l(-1) were found inhibitory. The isolate JS-1 characterized as Stenotrophomonas acidaminiphila was capable of utilizing butachlor as sole source of carbon and energy. Besides being an efficient butachlor degrader, it substantially produces IAA. The bacterial strain JS-1 has a potential for butachlor remediation with a distinctive auxiliary attribute of plant growth stimulation.

  12. Instant Ember.js application development how-to

    CERN Document Server

    Bodmer, Marc

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Get the job done and learn as you go. A how-To book with practical recipes accompanied with rich screenshots for easy comprehension.This book follows a recipe-based approach that can be used both for problem solving or getting started with Ember.JS. Regardless of your skill level you should find this book useful and beneficial to any of your application development projects.Are you a frontend developer whose code has gotten out of control? This book will also show you how you can us

  13. Protein phosphatase 2A mediates JS-K-induced apoptosis by affecting Bcl-2 family proteins in human hepatocellular carcinoma HepG2 cells.

    Science.gov (United States)

    Liu, Ling; Huang, Zile; Chen, Jingjing; Wang, Jiangang; Wang, Shuying

    2018-04-25

    Protein phosphatase 2A (PP2A) is an important enzyme within various signal transduction pathways. The present study was investigated PP2A mediates JS-K-induced apoptosis by affecting Bcl-2 family protein. JS-K showed diverse inhibitory effects in five HCC cell lines, especially HepG2 cells. JS-K caused a dose- and time-dependent reduction in cell viability and increased in levels of LDH release. Meanwhile, JS-K- induced apoptosis was characterized by mitochondrial membrane potential reduction, Hoechst 33342 + /PI + dual staining, release of cytochrome c (Cyt c), and activation of cleaved caspase-9/3. Moreover, JS-K-treatment could lead to the activation of protein phosphatase 2A-C (PP2A-C), decrease of anti-apoptotic Bcl-2 family-protein expression including p-Bcl-2 (Ser70), Bcl-2, Bcl-xL, and Mcl-1 as well as the increase of pro-apoptosis Bcl-2 family-protein including Bim, Bad, Bax, and Bak. Furthermore, JS-K caused a marked increase of intracellular NO levels while pre-treatment with Carboxy-PTIO (a NO scavenger) reduced the cytotoxicity effects and the apoptosis rate. Meanwhile, pre-treatment with Carboxy-PTIO attenuated the JS-K-induced up-regulation of PP2A, Cyt c, and cleaved-caspase-9/3 activation. The silencing PP2A-C by siRNA could abolish the activation of PP2A-C, down-regulation of anti-apoptotic Bcl-2 family-protein (p-Bcl-2, Bcl-2, Bcl-xL, and Mcl-1), increase of pro-apoptosis Bcl-2 family-protein (Bim, Bad, Bax, and Bak) and apoptotic-related protein (Cyt c, cleaved caspase-9/3) that were caused by JS-K in HepG2 cells. In addition, pre-treatment with OA (a PP2A inhibitor) also attenuated the above effects induced by JS-K. In summary, NO release from JS-K induces apoptosis through PP2A activation, which contributed to the regulation of Bcl-2 family proteins. © 2018 Wiley Periodicals, Inc.

  14. Molecular characterization of two sweepoviruses from China and evaluation of the infectivity of cloned SPLCV-JS in Nicotiana benthamiana.

    Science.gov (United States)

    Bi, Huiping; Zhang, Peng

    2012-03-01

    Sweepoviruses are important begomoviruses that infect Ipomoea plants worldwide and cause sweet potato yield losses and cultivar decline. Two sweepoviruses, sweet potato leaf curl virus-Jiangsu (SPLCV-JS) and sweet potato leaf curl China virus-Zhejiang (SPLCCNV-ZJ), were cloned from diseased sweet potato plants collected in the Jiangsu and Zhejiang provinces of China. Sequence characterization and phylogenetic analysis demonstrated that both are typical monopartite begomoviruses and have close relationships to several reported SPLCV and SPLCCNV isolates, respectively, from Asian countries. Analysis of the protein alignments and subcellular localizations of the six SPLCV-JS proteins was also conducted to verify their putative functions. In Nicotiana benthamiana, an infectivity assay of the infectious SPLCV-JS clone resulted in mild symptoms and weak viral DNA accumulation. Interestingly, SPLCV-JS, together with a heterologous betasatellite DNA (tomato yellow leaf curl China virus isolate Y10 [TYLCCNV-Y10] DNA-β), showed a synergistic effect on enhanced symptom severity and viral DNA accumulation. This is the first reported infectious SPLCV clone.

  15. Statistical analysis of the irradiation process of various products in the industrial irradiator JS-6500

    International Nuclear Information System (INIS)

    Naquid G, C.

    2003-01-01

    In this work the methodology for the control of the irradiation service applied to disposable products of medical use, foods, medications, cosmetics and several to different dose in the Gamma Irradiation Plant, with radiation of Cobalt 60, by means of the Graphs of Quality Control by Variables. These they are used to check if the irradiation process has been carried out appropriately, or well, if the variations surpass the established limits in the one that influences some another factor. (Author)

  16. JS-K, a GST-activated nitric oxide donor prodrug, enhances chemo-sensitivity in renal carcinoma cells and prevents cardiac myocytes toxicity induced by Doxorubicin.

    Science.gov (United States)

    Qiu, Mingning; Ke, Longzhi; Zhang, Sai; Zeng, Xin; Fang, Zesong; Liu, Jianjun

    2017-08-01

    Doxorubicin, a highly effective and widely used anthracycline antibiotic in multiple chemotherapy regimens, has been limited by its cardiotoxicity. The aim of this study is to investigate the effect of nitric oxide donor prodrug JS-K on proliferation and apoptosis in renal carcinoma cells and cardiac myocytes toxicity induced by Doxorubicin and to explore possible p53-related mechanism in renal carcinoma cells. The effect of JS-K on anti-cancer activity of Doxorubicin was investigated in renal carcinoma cells via detecting cell proliferation, cytotoxicity, cell death and apoptosis and expressions of apoptotic-related proteins. Effect of p53 on the combination of JS-K and Doxorubicin was determined using p53 inhibitor Pifithrin-α and p53 activator III. Furthermore, the effect of JS-K on cardiac myocytes toxicity of Doxorubicin was investigated in H9c2 (2-1) cardiac myocytes via measuring cell growth, cell death and apoptosis, expressions of proteins involved in apoptosis and intracellular reactive oxygen species. We demonstrated that JS-K could increase Doxorubicin-induced renal carcinoma cell growth suppression and apoptosis and could increase expressions of proteins that are involved in apoptosis. Additionally, Pifithrin-α reversed the promoting effect of JS-K on Doxorubicin-induced renal carcinoma cell apoptosis; conversely, the p53 activator III exacerbated the promoting effect of JS-K on Doxorubicin-induced renal carcinoma cell apoptosis. Furthermore, JS-K protected H9c2 (2-1) cardiac myocytes against Doxorubicin-induced toxicity and decreased Doxorubicin-induced reactive oxygen species production. JS-K enhances the anti-cancer activity of Doxorubicin in renal carcinoma cells by upregulating p53 expression and prevents cardiac myocytes toxicity of Doxorubicin by decreasing oxidative stress.

  17. BioJS DAGViewer: A reusable JavaScript component for displaying directed graphs.

    Science.gov (United States)

    Kalderimis, Alexis; Stepan, Radek; Sullivan, Julie; Lyne, Rachel; Lyne, Michael; Micklem, Gos

    2014-01-01

    The DAGViewer BioJS component is a reusable JavaScript component made available as part of the BioJS project and intended to be used to display graphs of structured data, with a particular emphasis on Directed Acyclic Graphs (DAGs). It enables users to embed representations of graphs of data, such as ontologies or phylogenetic trees, in hyper-text documents (HTML). This component is generic, since it is capable (given the appropriate configuration) of displaying any kind of data that is organised as a graph. The features of this component which are useful for examining and filtering large and complex graphs are described. http://github.com/alexkalderimis/dag-viewer-biojs; http://github.com/biojs/biojs; http://dx.doi.org/10.5281/zenodo.8303.

  18. Participation of SKODA JS in the construction of the Temelin and Mochovce nuclear power plants

    International Nuclear Information System (INIS)

    Svec, A.; Zach, J.; Ruzicka, P.

    2000-01-01

    SKODA JS is the traditional manufacturer of WWER type reactor equipment and also supplier of the primary circuits and of equipment for the transport, refuelling and storage of fuel for Ver type nuclear power plants built in the Czech and Slovak Republics. The paper deals with activities of the company SKODA JS at two power plants whose reactor units are close to completion, viz. the Mochovce NPP in the Slovak Republic (4 x Ver 440 MW; unit 1 was put in operation in 1998, unit 2 is in the stage of commissioning, units 3 and 4 are not to be completed) and the Temelin NPP in the Czech Republic (2 x Ver 1000 MW, commissioning of units 1 and 2 is expected in 2001 and 2002, respectively). The scope of supplies to the two nuclear power plants (detailed design, delivery of equipment, installation, commissioning) and the course of construction from SKODA JS's viewpoint are described. The most important design changes and improvements made during the construction are highlighted. (author)

  19. From flipchart to glossy visualisation through collaboration and d3.js

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Representing complex data visually is an important tool for communication, and the CERN Knowledge Transfer Annual Report is no exception to this. I want to share with the audience our experience with data visualization through the strength of collaboration, and the power and simplicity of the d3.js javascript framework.

  20. Preclinical evaluation of the efficacy, pharmacokinetics and immunogenicity of JS-001, a programmed cell death protein-1 (PD-1) monoclonal antibody.

    Science.gov (United States)

    Fu, Jie; Wang, Fang; Dong, Li-Hou; Zhang, Jing; Deng, Cheng-Lian; Wang, Xue-Li; Xie, Xin-Yao; Zhang, Jing; Deng, Ruo-Xian; Zhang, Li-Bo; Wu, Hai; Feng, Hui; Chen, Bo; Song, Hai-Feng

    2017-05-01

    JS-001 is the first monoclonal antibody (mAb) against programmed cell death protein-1 (PD-1) approved by the China Food and Drug Administration (CFDA) into the clinical trails. To date, however, no pre-clinical pharmacological and pharmacokinetic (PK) data are available. In this study, we investigated the efficacy of JS-001 and conducted a preclinical PK study, including the monitoring of anti-drug antibodies (ADAs). We found that JS-001 specifically bound to PD-1 antigen with an EC 50 of 21 nmol/L, and competently blocked the binding of PD-1 antigen to PD-L1 and PD-L2 with IC 50 of 3.0 and 3.1 nmol/L, respectively. Furthermore, JS-001 displayed distinct species cross-reactivity: it could bind to the PD-1 antigen on the peripheral blood mononuclear cells (PBMCs) of humans and cynomolgus monkeys, but not to those of mice and woodchucks; the K d values for the interaction between JS-001 and PD-1 antigens on CD8 + T cells of human and cynomolgus monkey were 2.1 nmol/L and 1.2 nmol/L, respectively. In vitro, treatment with JS-001 (0.01-10 μg/mL) dose-dependently stimulated human T cell proliferation, as well as IFN-γ and TNF-α secretion. In HBsAg-vaccinated cynomolgus monkeys, the expression of PD-1 + /CD4 + and PD-1 + /CD8 + was significantly elevated, intramuscular injection of JS-001 (1 and 10 mg/kg) resulted in dramatic decreases in PD-1 + /CD4 + and PD-1 + /CD8 + expression in a dose-dependent manner, which was supported by PD-1 receptor occupancy (RO) results. In the PK study, 18 cynomolgus monkeys treated with single, ascending doses of 1, 10, and 75 mg/kg, and another 6 cynomolgus monkeys received 10 mg/kg successive administration. The plasma clearance of JS-001 followed a linear PK profile with single administration in the 1 and 10 mg/kg groups and a non-linear PK profile in the 75 mg/kg group. In the successive 10 mg/kg administration group, no drug accumulation was observed. But the AUC from the last exposure was lower than that of the first

  1. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells.

    Science.gov (United States)

    Laschak, Martin; Spindler, Klaus-Dieter; Schrader, Andres J; Hessenauer, Andrea; Streicher, Wolfgang; Schrader, Mark; Cronauer, Marcus V

    2012-03-30

    Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen receptor(AR)-signaling in castration resistant prostate cancer (CRPC). Prostate cancer (PCa) cells were treated with JS-K, a diazeniumdiolate derivate capable of generating large amounts of intracellular NO following activation by glutathione S-transferase. Generation of NO was determined indirectly by the detection of nitrate in tissue culture medium or by immunodetection of nitrotyrosine in the cytoplasm. Effects of JS-K on intracellular AR-levels were determined by western blotting. AR-dimerization was analyzed by mammalian two hybrid assay, nuclear translocation of the AR was visualized in PCa cells transfected with a green fluorescent AR-Eos fusion protein using fluorescence microscopy. Modulation of AR- and WNT-signalling by JS-K was investigated using reporter gene assays. Tumor cell proliferation following JS-K treatment was measured by MTT-Assay. The NO-releasing compound JS-K was shown to inhibit AR-mediated reporter gene activity in 22Rv1 CRPC cells. Inhibition of AR signaling was neither due to an inhibition of nuclear import nor to a reduction in AR-dimerization. In contrast to previously tested NO-donors, JS-K was able to reduce the intracellular concentration of functional AR. This could be attributed to the generation of extremely high intracellular levels of the free radical NO as demonstrated indirectly by high levels of nitrotyrosine in JS-K treated cells. Moreover, JS-K diminished WNT-signaling in AR-positive 22Rv1 cells. In line with these observations, castration resistant 22Rv1 cells were found to be more susceptible to the growth inhibitory effects of JS-K than the androgen dependent LNCaP which do not exhibit an active WNT-signaling pathway. Our results

  2. JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell.

    Science.gov (United States)

    Liu, Zhengyun; Li, Guangmin; Gou, Ying; Xiao, Dongyan; Luo, Guo; Saavedra, Joseph E; Liu, Jie; Wang, Huan

    2017-08-01

    Hepatocellular carcinoma (HCC) is the most important cause of cancer-related death, and 85% of HCC is caused by chronic HBV infection, the prognosis of patients and the reduction of HBV DNA levels remain unsatisfactory. JS-K, a nitric oxide-releasing diazeniumdiolates, is effective against various tumors, but little is known on its effects on HBV positive HCC. We found that JS-K reduced the expression of HBsAg and HBeAg in HBV-positive HepG2.2.15 cells. This study aimed to further examine anti-tumor effects of JS-K on HepG2.2.15 cells. The MTT assay and colony forming assay were used to study the cell growth inhibition of JS-K; scratch assay and transwell assay were performed to detect cell migration. The cell cycle was detected by flow cytometry. The immunofluorescence, flow cytometry analysis, and western blot were used to study DNA damage and cell apoptosis. JS-K inhibited HepG2.2.15 cell growth in a dose-dependent manner, suppressed cell colony formation and migration, arrested cells gather in the G2 phase. JS-K (1-20μM) increased the expression of DNA damage-associated protein phosphorylation H 2 AX (γH 2 AX), phosphorylation of checkpoint kinase 1 (p-Chk1), phosphorylation of checkpoint kinase 2 (p-Chk2), ataxia-telangiectasia mutated (ATM), phosphorylation of ataxia-telangiectasia mutated rad3-related (p-ATR) and apoptotic-associated proteins cleaved caspase-3, cleaved caspase-7, cleaved poly ADP-ribose polymerase (cleaved PARP). The study demonstrated JS-K is effective against HBV-positive HepG2.2.15 cells, the mechanisms are not only related to inhibition of HBsAg and HBeAg secretion, but also related with induction of DNA damage and apoptosis. JS-K is a promising anti-cancer candidate against HBV-positive HCC. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  3. JS-K, a nitric oxide-releasing prodrug, modulates ß-catenin/TCF signaling in leukemic Jurkat cells: evidence of an S-nitrosylated mechanism.

    Science.gov (United States)

    Nath, Niharika; Chattopadhyay, Mitali; Pospishil, Liliya; Cieciura, Lucyna Z; Goswami, Satindra; Kodela, Ravinder; Saavedra, Joseph E; Keefer, Larry K; Kashfi, Khosrow

    2010-12-01

    β-Catenin is a central player of the Wnt signaling pathway that regulates cell-cell adhesion and may promote leukemia cell proliferation. We examined whether JS-K, an NO-donating prodrug, modulates the Wnt/β-catenin/TCF-4 signaling pathway in Jurkat T-Acute Lymphoblastic Leukemia cells. JS-K inhibited Jurkat T cell growth in a concentration and time-dependent manner. The IC(50)s for cell growth inhibition were 14±0.7 and 9±1.2μM at 24 and 48h, respectively. Treatment of the cells with JS-K for 24h, caused a dose-dependent increase in apoptosis from 16±3.3% at 10μM to 74.8±2% at 100μM and a decrease in proliferation. This growth inhibition was also due, in part, to alterations in the different phases of the cell cycle. JS-K exhibited a dose-dependent cytotoxicity as measured by LDH release at 24h. However, between 2 and 8h, LDH release was less than 20% for any indicated JS-K concentration. The β-catenin/TCF-4 transcriptional inhibitory activity was reduced by 32±8, 63±5, and 93±2% at 2, 10, and 25μM JS-K, respectively, based on luciferase reporter assays. JS-K reduced nuclear β-catenin and cyclin D1 protein levels, but cytosolic β-catenin expression did not change. Based on a time-course assay of S-nitrosylation of proteins by a biotin switch assay, S-nitrsolyation of nuclear β-catenin was determined to precede its degradation. A comparison of the S-nitrosylated nuclear β-catenin to the total nuclear β-catenin showed that β-catenin protein levels were degraded at 24h, while S-nitrosylation of β-catenin occurred earlier at 0-6h. The NO scavenger PTIO abrogated the JS-K mediated degradation of β-catenin demonstrating the need for NO. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Shore displacement in northern Uppland during the last 6500 calender years

    Energy Technology Data Exchange (ETDEWEB)

    Hedenstroem, Anna; Risberg, Jan [Stockholm Univ. (Sweden). Dept. of Physical Geography and Quaternary Geology

    2003-10-01

    This report describes the shore displacement in northern Uppland, Sweden. Four lake basins were investigated regarding elevation and age of their isolation events. The methods applied were diatom stratigraphy and AMS radiocarbon datings of terrestrial macrofossils, together with analysis of water, organic carbon and calcium carbonate in the sediment. Lake Barsjoe (22.5 masl -meters above sea level) was isolated 3,200 cal yrs BP, Lake Landholmssjoen (16.0 masl) 2,200 cal yrs BP, Lake Soedra Aassjoen (10.8 masl) 1,400 cal yrs BP and Lake Eckarfjaerden (5.5 masl) 850 cal yrs BP. Combined with six basins located at approximately the 70 m Litorina Limit isobase it was concluded that the shore displacement during the last 6500 calendar years was regressive in nature. The isolation processes, however, seem to have been prolonged at 4750-4150 cal yrs BP, 2500-2200 cal yrs Bp and 1100-850 cal yrs BP. These events can be correlated with eustatic sea level rises recorded in the Stockholm area. The diatom succession during the formation of the oligotrophic hardwater Lakes Barsjoe, Landholmssjoen and Eckarfjaerden differs from the brownwater Lake Soedra Aasjoen. Short pre-isolation sequences indicate that erosion has affected the four basins investigated. Accumulation rates in the lake basins vary between 0.5 mm/year in Lake Barsjoe and 1.5 mm/year in Lake Soedra Aasjoen.

  5. Shore displacement in northern Uppland during the last 6500 calender years

    International Nuclear Information System (INIS)

    Hedenstroem, Anna; Risberg, Jan

    2003-10-01

    This report describes the shore displacement in northern Uppland, Sweden. Four lake basins were investigated regarding elevation and age of their isolation events. The methods applied were diatom stratigraphy and AMS radiocarbon datings of terrestrial macrofossils, together with analysis of water, organic carbon and calcium carbonate in the sediment. Lake Barsjoe (22.5 masl -meters above sea level) was isolated 3,200 cal yrs BP, Lake Landholmssjoen (16.0 masl) 2,200 cal yrs BP, Lake Soedra Aassjoen (10.8 masl) 1,400 cal yrs BP and Lake Eckarfjaerden (5.5 masl) 850 cal yrs BP. Combined with six basins located at approximately the 70 m Litorina Limit isobase it was concluded that the shore displacement during the last 6500 calendar years was regressive in nature. The isolation processes, however, seem to have been prolonged at 4750-4150 cal yrs BP, 2500-2200 cal yrs Bp and 1100-850 cal yrs BP. These events can be correlated with eustatic sea level rises recorded in the Stockholm area. The diatom succession during the formation of the oligotrophic hardwater Lakes Barsjoe, Landholmssjoen and Eckarfjaerden differs from the brownwater Lake Soedra Aasjoen. Short pre-isolation sequences indicate that erosion has affected the four basins investigated. Accumulation rates in the lake basins vary between 0.5 mm/year in Lake Barsjoe and 1.5 mm/year in Lake Soedra Aasjoen

  6. SKODA JS in Central and Eastern European markets

    International Nuclear Information System (INIS)

    Luptacik, P.

    2006-01-01

    During the past decade, SKODA JS a.s. gained a leading position in the manufacture of equipment for the nuclear power sector in Central and Eastern Europe. The company benefited from its experience accumulated during the construction of VVER 440 and VVER 1000 NPPs at a time that saw a global decrease in popularity of the nuclear power sector. The company is building its success on a comprehensive understanding of the function of the primary coolant circuit and efforts to upgrade the equipment and processes so as to reflect new requirements in terms of safety and reactor unit service life. (orig.)

  7. A Low-mass Exoplanet Candidate Detected by K2 Transiting the Praesepe M Dwarf JS 183

    Science.gov (United States)

    Pepper, Joshua; Gillen, Ed; Parviainen, Hannu; Hillenbrand, Lynne A.; Cody, Ann Marie; Aigrain, Suzanne; Stauffer, John; Vrba, Frederick J.; David, Trevor; Lillo-Box, Jorge; Stassun, Keivan G.; Conroy, Kyle E.; Pope, Benjamin J. S.; Barrado, David

    2017-04-01

    We report the discovery of a repeating photometric signal from a low-mass member of the Praesepe open cluster that we interpret as a Neptune-sized transiting planet. The star is JS 183 (HSHJ 163, EPIC 211916756), with T eff = 3325 ± 100 K, M * = 0.44 ± 0.04 M ⊙, R * = 0.44 ± 0.03 R ⊙, and {log}{g}* = 4.82+/- 0.06. The planet has an orbital period of 10.134588 days and a radius of R P = 0.32 ± 0.02 R J. Since the star is faint at V = 16.5 and J = 13.3, we are unable to obtain a measured radial velocity orbit, but we can constrain the companion mass to below about 1.7 M J, and thus well below the planetary boundary. JS 183b (since designated as K2-95b) is the second transiting planet found with K2 that resides in a several-hundred-megayear open cluster; both planets orbit mid-M dwarf stars and are approximately Neptune sized. With a well-determined stellar density from the planetary transit, and with an independently known metallicity from its cluster membership, JS 183 provides a particularly valuable test of stellar models at the fully convective boundary. We find that JS 183 is the lowest-density transit host known at the fully convective boundary, and that its very low density is consistent with current models of stars just above the fully convective boundary but in tension with the models just below the fully convective boundary.

  8. JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells.

    Science.gov (United States)

    Kiziltepe, Tanyel; Hideshima, Teru; Ishitsuka, Kenji; Ocio, Enrique M; Raje, Noopur; Catley, Laurence; Li, Chun-Qi; Trudel, Laura J; Yasui, Hiroshi; Vallet, Sonia; Kutok, Jeffery L; Chauhan, Dharminder; Mitsiades, Constantine S; Saavedra, Joseph E; Wogan, Gerald N; Keefer, Larry K; Shami, Paul J; Anderson, Kenneth C

    2007-07-15

    Here we investigated the cytotoxicity of JS-K, a prodrug designed to release nitric oxide (NO(*)) following reaction with glutathione S-transferases, in multiple myeloma (MM). JS-K showed significant cytotoxicity in both conventional therapy-sensitive and -resistant MM cell lines, as well as patient-derived MM cells. JS-K induced apoptosis in MM cells, which was associated with PARP, caspase-8, and caspase-9 cleavage; increased Fas/CD95 expression; Mcl-1 cleavage; and Bcl-2 phosphorylation, as well as cytochrome c, apoptosis-inducing factor (AIF), and endonuclease G (EndoG) release. Moreover, JS-K overcame the survival advantages conferred by interleukin-6 (IL-6) and insulin-like growth factor 1 (IGF-1), or by adherence of MM cells to bone marrow stromal cells. Mechanistic studies revealed that JS-K-induced cytotoxicity was mediated via NO(*) in MM cells. Furthermore, JS-K induced DNA double-strand breaks (DSBs) and activated DNA damage responses, as evidenced by neutral comet assay, as well as H2AX, Chk2 and p53 phosphorylation. JS-K also activated c-Jun NH(2)-terminal kinase (JNK) in MM cells; conversely, inhibition of JNK markedly decreased JS-K-induced cytotoxicity. Importantly, bortezomib significantly enhanced JS-K-induced cytotoxicity. Finally, JS-K is well tolerated, inhibits tumor growth, and prolongs survival in a human MM xenograft mouse model. Taken together, these data provide the preclinical rationale for the clinical evaluation of JS-K to improve patient outcome in MM.

  9. Phosphate-binding protein from Polaromonas JS666: purification, characterization, crystallization and sulfur SAD phasing

    Energy Technology Data Exchange (ETDEWEB)

    Pegos, Vanessa R.; Hey, Louis; LaMirande, Jacob; Pfeffer, Rachel; Lipsh, Rosalie; Amitay, Moshe; Gonzalez, Daniel; Elias, Mikael (JCT-Israel); (UMM); (CNRS-UMR)

    2017-05-25

    Phosphate-binding proteins (PBPs) are key proteins that belong to the bacterial ABC-type phosphate transporters. PBPs are periplasmic (or membrane-anchored) proteins that capture phosphate anions from the environment and release them to the transmembrane transporter. Recent work has suggested that PBPs have evolved for high affinity as well as high selectivity. In particular, a short, unique hydrogen bond between the phosphate anion and an aspartate residue has been shown to be critical for selectivity, yet is not strictly conserved in PBPs. Here, the PBP fromPolaromonasJS666 is focused on. Interestingly, this PBP is predicted to harbor different phosphate-binding residues to currently known PBPs. Here, it is shown that the PBP fromPolaromonasJS666 is capable of binding phosphate, with a maximal binding activity at pH 8. Its structure is expected to reveal its binding-cleft configuration as well as its phosphate-binding mode. Here, the expression, purification, characterization, crystallization and X-ray diffraction data collection to 1.35 Å resolution of the PBP fromPolaromonasJS666 are reported.

  10. Biodegradation of isoproturon using a novel Pseudomonas aeruginosa strain JS-11 as a multi-functional bioinoculant of environmental significance.

    Science.gov (United States)

    Dwivedi, Sourabh; Singh, Braj Raj; Al-Khedhairy, Abdulaziz A; Musarrat, Javed

    2011-01-30

    Biodegradation of phenylurea herbicide isoproturon was studied in soil microcosm bioaugmented with a novel bacterial strain JS-11 isolated from wheat rhizosphere. The molecular characterization based on 16SrDNA sequence homology confirmed its identity as Pseudomonas aeruginosa strain JS-11. The herbicide was completely degraded within 20 days at ambient temperature with the rate constant of 0.08 day(-1), following the first-order rate kinetics. In stationary phase, at a cell density of 6.5 × 10(9) CFU mL(-1), the bacteria produced substantially increased amounts of indole acetic acid (IAA) in the presence of tryptophan as compared with the control. Also, the bacteria exhibited a time-dependent increase in the amount of tri-calcium phosphate solubilization in Pikovskaya's medium. Further screening of the strain JS-11 for auxiliary activities revealed its remarkable capability of producing the siderophores and hydrogen cyanide (HCN), besides antifungal activity against a common phytopathogen Fusarium oxysporum. Thus, the versatile P. aeruginosa strain JS-11 with innate potential for multifarious biological activities is envisaged as a super-bioinoculant for exploitation in the integrated bioremediation, plant growth and disease management (IBPDM) in contaminated agricultural soils. Copyright © 2010 Elsevier B.V. All rights reserved.

  11. Tīmekļa lietotņu veiktspējas optimizācija AngularJS lietotnēs

    OpenAIRE

    Niedrītis, Andris

    2016-01-01

    Darbā Tīmekļa lietotņu veiktspējas optimizācija AngularJS lietotnēs tiek pētīts klienta puses lietotņu izstrādes ietvars AngularJS un tā tipiskākie veiktspējas trūkumi un izstrādātāju kļūdas, kā arī veidi kā risināt šīs kļūdas un uzlabot lietotņu veiktspēju. Pētījums balstās uz informāciju, kas atrodama paša ietvara oficiālajā dokumentācijā un pieredzējušu AngularJS lietotāju viedokļiem par šī ietvara potenciālajām problēmām un to risinājumiem. Pārsvarā tiek aplūkoti veidi kā veidot lietotne...

  12. Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.

    Science.gov (United States)

    Weidensteiner, Claudia; Reichardt, Wilfried; Shami, Paul J; Saavedra, Joseph E; Keefer, Larry K; Baumer, Brunhilde; Werres, Anna; Jasinski, Robert; Osterberg, Nadja; Weyerbrock, Astrid

    2013-04-01

    Nitric oxide (NO) released from NO donors can be cytotoxic in tumor cells and can enhance the transport of drugs into brain tumors by altering blood-tumor barrier permeability. The NO donor JS-K [O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] releases NO upon enzymatic activation selectively in cells overexpressing glutathione-S-transferases (GSTs) such as gliomas. Thus, JS-K-dependent NO effects - especially on cell viability and vascular permeability - were investigated in U87 glioma cells in vitro and in an orthotopic U87 xenograft model in vivo by magnetic resonance imaging (MRI). In vitro experiments showed dose-dependent antiproliferative and cytotoxic effects in U87 cells. In addition, treatment of U87 cells with JS-K resulted in a dose-dependent activation of soluble guanylate cyclase and intracellular accumulation of cyclic guanosine monophosphate (cGMP) which was irreversibly inhibited by the selective inhibitor of soluble guanylate cyclase ODQ (1H-[1,2,4]oxadiazolo(4,3a)quinoxaline-1-one). Using dynamic contrast enhanced MRI (DCE-MRI) as a minimally invasive technique, we demonstrated for the first time a significant increase in the DCE-MRI read-out initial area under the concentration curve (iAUC60) indicating an acute increase in blood-tumor barrier permeability after i.v. treatment with JS-K. Repeated MR imaging of animals with intracranial U87 gliomas under treatment with JS-K (3.5 μmol/kg JS-K 3×/week) and of untreated controls on day 12 and 19 after tumor inoculation revealed no significant changes in tumor growth, edema formation or tumor perfusion. Immunohistochemical workup of the brains showed a significant antiproliferative effect of JS-K in the gliomas. Taken together, in vitro and in vivo data suggest that JS-K has antiproliferative effects in U87 gliomas and opens the blood-tumor barrier by activation of the NO/cGMP signaling pathway. This might be a novel approach to facilitate entry of therapeutic

  13. Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium.

    Science.gov (United States)

    Wollenberg, Rasmus D; Donau, Søren S; Nielsen, Thorbjørn T; Sørensen, Jens L; Giese, Henriette; Wimmer, Reinhard; Søndergaard, Teis E

    2016-11-01

    Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported. The fungicide causes the hypha to become entangled and unable to extend vertically. This implies that type I myosin in Fusarium is essential for hyphal and mycelia propagation. The K216Q substitution correlates with reduced susceptibility in F. avenaceum. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Determination of diacylhydrazines-type insect growth regulator JS-118 residues in cabbage and soil by high performance liquid chromatography with DAD detection.

    Science.gov (United States)

    Hu, J-Y; Deng, Z-B; Qin, D-M

    2009-12-01

    JS-118 is a diacylhydrazines-type insect growth regulator used extensively in China now. An analytical method for residues determination of JS-118 in cabbage and soil samples by high performance liquid chromatography with DAD detection was established and optimized. Primary secondary amine solid phase extraction cartridge was used for sample preparation. Mean recoveries for the analyte ranged from 96.6% to 107.0% with CV value less than 4.7%. The limit of quantification is 0.01 mg/kg. Direct confirmation of JS-118 residues in samples was realized by high performance liquid chromatography-mass spectrometry. The proposed method is simple, rapid and reliable to perform and could be utilized for monitoring of pesticides residues.

  15. Control of selected VVER components life time SKODA JS a.s. experience

    International Nuclear Information System (INIS)

    Zdebor, J.; Pribulla, E.

    2005-01-01

    Experience from the operation of nuclear power plants with type VVER reactors has shown that the life time management of a number of nuclear reactor components is technically as well as with respect to safety substantiated even at the time which exceeds their originally designed life time. To accept such solution it was necessary to develop and implement a number of programs based on which it was possible to evaluate the actual condition of monitored equipment. It is a condition allowing to adopt solution concerning the possibility of their further operation. Experience from the manufacture of 21 sets of reactor equipment for VVER 440 and 3 sets VVER 1000 has been gathered in SKODA JS a.s. which have been completed by experience from service activities performed at operated nuclear power plants. Analyses of manufacturing data and in-service inspection results completed by a lot of laboratory tests have become the basis for the development of selected VVER components life time management programs. The paper focuses on the life time management of those VVER components which SKODA JS a.s. has most experience with. (authors)

  16. Functional genomics provides insights into the role of Propionibacterium freudenreichii ssp. shermanii JS in cheese ripening.

    Science.gov (United States)

    Ojala, Teija; Laine, Pia K S; Ahlroos, Terhi; Tanskanen, Jarna; Pitkänen, Saara; Salusjärvi, Tuomas; Kankainen, Matti; Tynkkynen, Soile; Paulin, Lars; Auvinen, Petri

    2017-01-16

    Propionibacterium freudenreichii is a commercially important bacterium that is essential for the development of the characteristic eyes and flavor of Swiss-type cheeses. These bacteria grow actively and produce large quantities of flavor compounds during cheese ripening at warm temperatures but also appear to contribute to the aroma development during the subsequent cold storage of cheese. Here, we advance our understanding of the role of P. freudenreichii in cheese ripening by presenting the 2.68-Mbp annotated genome sequence of P. freudenreichii ssp. shermanii JS and determining its global transcriptional profiles during industrial cheese-making using transcriptome sequencing. The annotation of the genome identified a total of 2377 protein-coding genes and revealed the presence of enzymes and pathways for formation of several flavor compounds. Based on transcriptome profiling, the expression of 348 protein-coding genes was altered between the warm and cold room ripening of cheese. Several propionate, acetate, and diacetyl/acetoin production related genes had higher expression levels in the warm room, whereas a general slowing down of the metabolism and an activation of mobile genetic elements was seen in the cold room. A few ripening-related and amino acid catabolism involved genes were induced or remained active in cold room, indicating that strain JS contributes to the aroma development also during cold room ripening. In addition, we performed a comparative genomic analysis of strain JS and 29 other Propionibacterium strains of 10 different species, including an isolate of both P. freudenreichii subspecies freudenreichii and shermanii. Ortholog grouping of the predicted protein sequences revealed that close to 86% of the ortholog groups of strain JS, including a variety of ripening-related ortholog groups, were conserved across the P. freudenreichii isolates. Taken together, this study contributes to the understanding of the genomic basis of P. freudenreichii

  17. Uptake and incorporation of labeled tryptophan isomers into IAA in the jsR1 mutant of Lemna gibba

    International Nuclear Information System (INIS)

    Baldi, B.G.; Maher, B.R.; Cohen, J.D.

    1989-01-01

    Analyses of the IAA-overproducing mutant of Lemna have been initiated in order to study in vivo biosynthesis of IAA. Using radiolabelled tryptophan isomers prepared from commercial sources of 14 C-D,L tryptophan by chiral separation kinetics of uptake of L and D tryptophan were determined for sterile cultures of individual jsR 1 four-frond colonies. Over a 24 h period, about 50% of the radioactivity from 14 C-L-TRP in media, or about 25% from 14 C-D-TRP, was found in the plant tissue. Maximal rates of uptake were seen in the first six hors for both isomers. Endogenous levels of tryptophan determined in jsR 1 as measures of pool sizes in vivo show 5 to 10 ug/g FW total tryptophan with less than 1% in the D isomer form. Information on uptake and endogenous pool sizes of tryptophan isomers is being used for feeding of stable isotope labeled tryptophan ( 13 C, 14 N) to jsR 1 at physiological levels. Analyses of incorporation of label into IAA using GC-MS and high resolution mass spectrometry are currently underway

  18. Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme.

    Science.gov (United States)

    Günzle, Jessica; Osterberg, Nadja; Saavedra, Joseph E; Weyerbrock, Astrid

    2016-09-01

    The nitric oxide (NO) donor JS-K is specifically activated by glutathione S-transferases (GSTs) in GST-overexpressing cells. We have shown the induction of cell death in glioblastoma multiforme (GBM) cells at high JS-K doses but the mechanism remains unclear. The aim of this study was to determine whether NO-induced cell death is triggered by induction of apoptotic or necrotic pathways. For the first time, we demonstrate that NO induces cell death via mitotic catastrophe (MC) with non-apoptotic mechanisms in GBM cells. Moreover, the level of morphological changes indicating MC correlates with increased necrosis. Therefore, we conclude that MC is the main mechanism by which GBM cells undergo cell death after treatment with JS-K associated with necrosis rather than apoptosis. In addition, we show that PARP1 is not an exclusive marker for late apoptosis but is also involved in MC. Activating an alternative way of cell death can be useful for the multimodal cancer therapy of GBM known for its strong anti-apoptotic mechanisms and drug resistance.

  19. Criticality safety analyses in SKODA JS a.s

    International Nuclear Information System (INIS)

    Mikolas, P.; Svarny, J.

    1999-01-01

    This paper describes criticality safety analyses of spent fuel systems for storage and transport of spent fuel performed in SKODA JS s.r.o.. Analyses were performed for different systems both at NPP site including originally designed spent fuel pool with a large pitch between assemblies without any special absorbing material, high density spent fuel pool with an additional absorption by boron steel, depository rack for fresh fuel assemblies with a very large pitch between fuel assemblies, a container for transport of fresh fuel into the reactor pool and a cask for transport and storage of spent fuel and container for final storage depository. required subcriticality has been proven taking into account all possible unfavourable conditions, uncertainties etc. In two cases, burnup credit methodology is expected to be used. (Authors)

  20. Implementation of CMS Central DAQ monitoring services in Node.js

    CERN Document Server

    Vougioukas, Michail

    2015-01-01

    This report summarizes my contribution to the CMS Central DAQ monitoring system, in my capacity as a CERN Summer Students Programme participant, from June to September 2015. Specifically, my work was focused on rewriting – from Apache/PHP to Node.js/Javascript - and optimizing real-time monitoring web services (mostly Elasticsearch-based but also some Oracle-based) for the CMS Data Acquisition (Run II Filterfarm). Moreover, it included an implementation of web server caching, for better scalability when simultaneous web clients use the services. Measurements confirmed that the software developed during this project has indeed a potential to provide scalable services.

  1. High abundance of JS-1- and Chloroflexi-related Bacteria in deeply buried marine sediments revealed by quantitative, real-time PCR.

    Science.gov (United States)

    Blazejak, Anna; Schippers, Axel

    2010-05-01

    Sequences of members of the bacterial candidate division JS-1 and the classes Anaerolineae and Caldilineae of the phylum Chloroflexi are frequently found in 16S rRNA gene clone libraries obtained from marine sediments. Using a newly designed quantitative, real-time PCR assay, these bacterial groups were jointly quantified in samples from near-surface and deeply buried marine sediments from the Peru margin, the Black Sea, and a forearc basin off the island of Sumatra. In near-surface sediments, sequences of the JS-1 as well as Anaerolineae- and Caldilineae-related Bacteria were quantified with significantly lower 16S rRNA gene copy numbers than the sequences of total Bacteria. In contrast, in deeply buried sediments below approximately 1 m depth, similar quantities of the 16S rRNA gene copies of these specific groups and Bacteria were found. This finding indicates that JS-1 and Anaerolineae- and Caldilineae-related Bacteria might dominate the bacterial community in deeply buried marine sediments and thus seem to play an important ecological role in the deep biosphere.

  2. Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

    Directory of Open Access Journals (Sweden)

    RACHMAT FAJRIN

    2017-09-01

    Full Text Available PT IBM memiliki banyak klien di Indonesia, ini membuat persebaran produk (dalam hal ini mesin atm yang semakin meluas di wilayah Indonesia. Hal ini memicu PT IBM untuk menempatkan engineer dibanyak wilayah untuk memenuhi kebutuhan services dan maintenance. Untuk itu dalam penelitian ini dikembangkan sebuah sistem informasi geografis untuk pemetaan mesin dan tracking engineer dengan pemanfaatan geolocation yang bertujuan untuk menampilkan peta digital beserta lokasi mesin dan engineer di seluruh Indonesia, yang akan memudahkan PT IBM dalam pemberian tugas kepada engineer untuk services dan maintenance ke lokasi mesin terdekat. Sistem ini dibangun menggunakan beberapa software open source yaitu, Node.JS dan Express.JS yang merupakan server-side javascript web platform, Handlebars untuk template engine, MySQL sebagai database storage, Postman yang berfungsi sebagai API (Application Program Interface testing, Google Maps API untuk implementasi peta digital dan juga Firebase Cloud Messaging (FCM untuk platform mengirim notifikasi dari web ke device engineer.Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

  3. Kekule.js: An Open Source JavaScript Chemoinformatics Toolkit.

    Science.gov (United States)

    Jiang, Chen; Jin, Xi; Dong, Ying; Chen, Ming

    2016-06-27

    Kekule.js is an open-source, object-oriented JavaScript toolkit for chemoinformatics. It provides methods for many common tasks in molecular informatics, including chemical data input/output (I/O), two- and three-dimensional (2D/3D) rendering of chemical structure, stereo identification, ring perception, structure comparison, and substructure search. Encapsulated widgets to display and edit chemical structures directly in web context are also supplied. Developed with web standards, the toolkit is ideal for building chemoinformatics applications over the Internet. Moreover, it is highly platform-independent and can also be used in desktop or mobile environments. Some initial applications, such as plugins for inputting chemical structures on the web and uses in chemistry education, have been developed based on the toolkit.

  4. Application of standard softWare of the CDC-6500 interactive graphic therminal for representation of spiral scanning data and event saving

    International Nuclear Information System (INIS)

    Nehrguj, B.; Ososkov, G.A.

    1978-01-01

    A system of programs, based on a standard graphic display software, is developed which enables the user to display the results of spiral scanning using a terminal keyboard and a FILTR program. Quality assessment of filtering is also available. The use of a cursor which provides a certain feedback between the display and the CDC-6500 computer provides good capabilities for the investigation of the filtering program failures and saves the most interesting events. To speed up scanning of events, a special program is written which performs pre-filtration and reduces 4 to 5 fold the amount of source numerical data of track projections. Its flowchart is based on the well-known method of cords, which allows to save 10-12 events/hour

  5. Honda WT20K1C 2 inch electric driven trash pump and Honda ES6500c generator

    International Nuclear Information System (INIS)

    1992-01-01

    Recovery of highly volatile hydrocarbon spills has always presented safety problems due to the explosive, flammable nature of the product being recovered. In an effort to increase safety, decrease spill response time, and improve recovery and/or pumping of hydrocarbons, an electric driven trash pump has been designed, developed, and tested. This pump has the capacity to recover and/or pump volatile and flammable substances such as condensate, gasoline, diesel fuel, and light gravity crude oil products in a safe manner. The pumping unit consists of an electric motor rated for use in hazardous locations, a trash pump with a Duraprene impeller and pump body, a motor/pump frame, and a Honda ES6500c generator that powers the pump motor through up to 100 feet of cable. A remote control switch is used to operate the unit so that workers can stay at least 30 m away while it is running. 5 figs

  6. [Construction and rescue of infectious cDNA clone of pigeon-origin Newcastle disease virus strain JS/07/04/Pi].

    Science.gov (United States)

    Zhu, Yan-Mei; Hu, Zeng-Lei; Song, Qing-Qing; Duan, Zhi-Qiang; Gu, Min; Hu, Shun-Lin; Wang, Xiao-Quan; Liu, Xiu-Fan

    2012-01-01

    Based on the complete genome sequence of pigeon-origin Newcastle disease virus strain JS/07/04/ Pi(genotype VIb), nine overlapped fragments covering its full-length genome were amplified by RT-PCR. The fragments were connected sequentially and then inserted into the transcription vector TVT7/R resulting in the TVT/071204 which contained the full genome of strain JS/07/04/Pi. The TVT/071204 was co-transfected with three helper plasmids pCI-NP, pCI-P and pCI-L into the BSR cells, and the transfected cells and culture supernatant were inoculated into 9-day-old SPF embryonated eggs 60 h post-transfection. The HA and HI tests were conducted following the death of embryonated eggs. The results showed that the allantoic fluids obtained were HA positive and the HA could be inhibited by anti-NDV serum which indicated that the strain JS/07/04/Pi was rescued successfully. The rescued virus rNDV/071204 showed similar growth kinetics to its parental virus in CEF. The successful recovery of this strain would contribute to the understanding of the host-specificity of pigeon-origin NDV and to the development of the novel vaccines against the NDV infection in pigeons.

  7. Genome Sequence of an Endophytic Fungus, Fusarium solani JS-169, Which Has Antifungal Activity.

    Science.gov (United States)

    Kim, Jung A; Jeon, Jongbum; Park, Sook-Young; Kim, Ki-Tae; Choi, Gobong; Lee, Hyun-Jung; Kim, Yangsun; Yang, Hee-Sun; Yeo, Joo-Hong; Lee, Yong-Hwan; Kim, Soonok

    2017-10-19

    An endophytic fungus, Fusarium solani strain JS-169, isolated from a mulberry twig, showed considerable antifungal activity. Here, we report the draft genome sequence of this strain. The assembly comprises 17 scaffolds, with an N 50 value of 4.93 Mb. The assembled genome was 45,813,297 bp in length, with a G+C content of 49.91%. Copyright © 2017 Kim et al.

  8. Induced absorption spectra of the infrared fundamental band of molecular deuterium at 77 K: S1( J)+S0( J) transitions

    International Nuclear Information System (INIS)

    Gillard, P.G.; Prasad, R.D.G.; Reddy, S.P.

    1984-01-01

    The collision-induced spectra of the fundamental band of normal D 2 in the high frequency region 3200--3700 cm -1 were recorded for gas densities in the range 80--140 amagat at 77 K with a 2 m absorption cell. The contribution to the intensity of the band in this region comes from the high frequency wings of quadrupolar transitions S 1 ( J) and Q 1 ( J)+S 0 ( J) with J = 0 and 1, and from the group of transitions S 1 (2) and Q 1 ( J)+S 0 (2) with J = 0, 1, and 2 as well as from the relatively weaker double rotational transitions of the type S 1 ( J)+S 0 ( J); the latter transitions arise from the intermolecular interaction between the anisotropic component of the polarizability of one of the colliding pairs of molecules and the quadrupole field of the other. The experimental profiles were analyzed by assuming appropriate line shape functions and using the theoretical matrix elements of the quadrupole moment, isotropic polarizability, and anisotropy of polarizability of the D 2 molecule. From this analysis the characteristic half-width parameters delta/sub q/2 and delta/sub q/4 of the quadrupolar transitions and the binary and ternary absorption coefficients of the S 1 ( J)+S 0 ( J) transitions have been obtained. The experimental value of the binary absorption coefficient of S 1 (0)+S 0 (0) is (2.2 +- 0.1) x 10 -9 cm -1 amagat -2 and the corresponding theoretical value is 1.53 x 10 -9 cm -1 amagat -2

  9. Características fisicoquímicas y microbiológicas de la saliva durante y después del embarazo

    OpenAIRE

    Martínez-Pabón, María C.; Martínez Delgado, Cecilia M.; López-Palacio, Ana M.; Patiño-Gómez, Lina M.; Arango-Pérez, Eduin A.

    2014-01-01

    Objetivo Identificar las variaciones producidas en algunos parámetros fisicoquímicos y microbiológicos de la saliva en un grupo de mujeres durante y después de la gestación. Materiales y Métodos Se recolectó saliva total estimulada en una cohorte de 35 mujeres embarazadas y después del parto. A cada muestra le fueron determinadas características fisicoquímicas (tasa de secreción, pH y capacidad amortiguadora) y microbiológicas (recuentos de bacterias acidogénicas). Resultados El pH y la capac...

  10. Karl Popper: antes y después de Kyoto

    Directory of Open Access Journals (Sweden)

    Zanotti, Gabriel

    1999-06-01

    Full Text Available Not available.En su último libro sobre Karl Popper, Mariano Artigas plantea una hermenéutica revolucionaria: muestra que la ética de Popper es el fundamento de su epistemología, y que el fundamento de esa ética está lejos del «conjeturalismo» que suele atribuirse a Popper. Artigas analiza qué significa en Popper la «fe irracional en la razón» y utiliza, como fuente inédita, el dramático relato que hace Popper de su relación con W. W. Bartley, por primera vez, en Kyoto, en 1992. Sea cual fuere la opinión del lector, el libro de Artigas divide la hermenéutica de Popper en un antes y un después.

  11. La hipnosis despierta setenta y cuatro años después

    OpenAIRE

    Capafons, Antonio

    1999-01-01

    La evidencia experimental obtenida de las investigaciones sobre hipnosis permite afirmar que no es necesario el que una persona esté relajada, aletargada o con los ojos cerrados para sentirse hipnotizada o para cumplir con las sugestiones hipnóticas. La hipnosis despierta surgió en un contexto en el que difícilmente podía florecer. Setenta y cuatro años después, no obstante, parece que existen fuertes indicios de que la hipnosis despierta es una de las líneas c...

  12. La narrativa colombiana después de García Márquez; Visión a vuelo de pájaro

    Directory of Open Access Journals (Sweden)

    Juan Gustavo Cobo Borda

    1988-01-01

    Full Text Available La publicación en 1967 de Cien años de soledad por la Editorial Sudamericana de Buenos Aires cambió el curso de la literatura colombiana. Hay una cronología que dice:" Antes de Cien años..., después de Cien años...". Hoy nos referiremos a ese "después de Cien años... ", utilizando una idea de Jorge Luis Borges en "Kafka y sus precursores", que es a su vez una idea de T. S. Eliot, que es a su vez... La idea es simple pero fecunda: el presente no sólo incide en el futuro. También modifica el pasado. La aparición de Cien años de soledad marcó a quienes escribirían ficción después. También alteró a quienes ya lo hacían antes. A los que en el momento de su aparición eran escritores con obra conocida. ¿De quiénes se trataba?

  13. Regeneración miocárdica en Ambystoma mexicanum después de lesión quirúrgica

    OpenAIRE

    Vargas-González, Alvaro; Prado-Zayago, Esteban; León-Olea, Martha; Guarner-Lans, Verónica; Cano-Martínez, Agustina

    2005-01-01

    Se realizó resección ventricular en el corazón de Ambystoma mexicanum, se evaluó si la restitución del tejido resulta de hipertrofia o de hiperplasia. Por medio de una tinción tricrómica se encontró que 5 días después del daño en el espacio de la resección se encontró un coágulo rodeado de fibras de colágena (83 ± 6%), músculo (10 ± 3%) y zonas sin tejido (7 ± 2%). Una proporción de 50 ± 4 y 90 ± 2% correspondió a tejido muscular 10 y 30 días después de la lesión. La tinción con bis-Benzimida...

  14. A Comparative biochemical study on two marine endophytes, Bacterium SRCnm and Bacillus sp. JS, Isolated from red sea algae.

    Science.gov (United States)

    Ahmed, Eman Fadl; Hassan, Hossam Mokhtar; Rateb, Mostafa Ezzat; Abdel-Wahab, Noha; Sameer, Somayah; Aly Taie, Hanan Anwar; Abdel-Hameed, Mohammed Sayed; Hammouda, Ola

    2016-01-01

    Two marine endophytic bacteria were isolated from the Red Sea algae; a red alga; Acanthophora dendroides and the brown alga Sargassum sabrepandum. The isolates were identified based on their 16SrRNA sequences as Bacterium SRCnm and Bacillus sp. JS. The objective of this study was to investigate the potential anti-microbial and antioxidant activities of the extracts of the isolated bacteria grown in different nutrient conditions. Compared to amoxicillin (25μg/disk) and erythromycin (15μg/disk), the extracts of Bacterium SRCn min media II, III, IV and V were potent inhibitors of the gram-positive bacterium Sarcina maxima even at low concentrations. Also, the multidrug resistant Staphylococcus aureus(MRSA) was more sensitive to the metabolites produced in medium (II) of the same endophyte than erythromycin (15μg/disk). A moderate activity of the Bacillus sp. JS extracts of media I and II was obtained against the same pathogen. The total compounds (500ug/ml) of both isolated endophytes showed moderate antioxidant activities (48.9% and 46.1%, respectively). LC/MS analysis of the bacterial extracts was carried out to investigate the likely natural products produced. Cyclo(D-cis-Hyp-L-Leu), dihydrosphingosine and 2-Amino-1,3-hexadecanediol were identified in the fermentation medium of Bacterium SRCnm, whereas cyclo (D-Pro-L-Tyr) and cyclo (L-Leu-L-Pro) were the suggested compounds of Bacillus sp. JS.

  15. Diseño de una crema regeneradora con quitina para después del bronceado

    Directory of Open Access Journals (Sweden)

    Patricia Pérez Ramos

    Full Text Available Introducción: después de tomar el sol resulta indispensable reparar la piel agredida por los rayos nocivos. Los cosmecéuticos para después del sol contienen elementos antinflamatorios, calmantes, hidratantes, suavizantes y regeneradores del epitelio, los cuales evitan o mitigan la sensación de dolor, tirantez, ardor y prurito. Objetivo: desarrollar una crema regeneradora con quitina para después del bronceado con la calidad requerida para reparar e hidratar la piel. Métodos: se realizaron dos diseños experimentales 2² (F1 y F2, en los que se utilizaron humectantes diferentes, glicerina y propilenglicol respectivamente. Se midieron como variables respuestas: el pH y la extensibilidad; además se analizaron las propiedades psicofisiológicas, la tensión de cizalla y las pruebas de centrifugación e influencia de la temperatura durante 60 días. Resultados: no existieron diferencias significativas entre el uso del propilenglicol o la glicerina, mientras que si fue notable la incidencia del alcohol cetílico en los valores de extensibilidad y pH. Se obtuvo como la mejor variante la I del diseño F2, en la que el alcohol cetílico se encontraba al 4 % y el propilenglicol al 3 %; el pH resultó 7,05 ± 0,00; la extensibilidad igual a 68,15 ± 1,51 y la tensión de cizalla de 1,93 ± 0,01; las propiedades psicofisiológicas resultaron satisfactorias y no hubo cremado ni coalescencia. Conclusiones: se puede considerar, atendiendo a las mediciones realizadas en el tiempo evaluado, características satisfactorias para las cremas elaboradas siendo la de menor costo, la variante I del diseño F2. La estabilidad física de las formulaciones, sometidas incluso las bases a pruebas de centrifugación e influencia de la temperatura, es indicativo de una buena compatibilidad entre el biopolímero estudiado y los excipientes de la formulación.

  16. Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

    Science.gov (United States)

    Shami, Paul J; Saavedra, Joseph E; Bonifant, Challice L; Chu, Jingxi; Udupi, Vidya; Malaviya, Swati; Carr, Brian I; Kar, Siddhartha; Wang, Meifeng; Jia, Lee; Ji, Xinhua; Keefer, Larry K

    2006-07-13

    The literature provides evidence that metabolic nitric oxide (NO) release mediates the cytotoxic activities (against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of structure R(2)N-N(O)=NO-Ar for which R(2)N is 4-(ethoxycarbonyl)piperazin-1-yl and Ar is 2,4-dinitrophenyl. Here we present comparative data on the potencies of JS-K and 41 other O(2)-arylated diazeniumdiolates as inhibitors of HL-60 human leukemia cell proliferation, as well as in the NCI 51-cell-line screen for six of them. The data show JS-K to be the most potent of the 42 in both screens and suggest that other features of its structure and metabolism besides NO release may contribute importantly to its activity. Results with control compounds implicate JS-K's arylating ability, and the surprisingly low IC(50) value of the N-(ethoxycarbonyl)piperazine byproduct of NO release suggests a role for the R(2)N moiety. In addition to the above-mentioned in vivo activities, JS-K is shown here to be carcinostatic in a rat liver cancer model.

  17. Inspection of the coupling part material degradation. Some experiences and results from SKODA JS related to internals

    International Nuclear Information System (INIS)

    Brynda, J.

    1998-01-01

    In this presentation some experiences and results from SKODA JS, related to internals, are reported. Sketches of the construction of WWER 440 RPV and internal's materials, including chemical composition are given. The results of hardness tests on internal parts are reported as well as some changes in the construction of internal parts which were made to improve their crack and fracture properties

  18. Neuroprotective Compound from an Endophytic Fungus, Colletotrichum sp. JS-0367.

    Science.gov (United States)

    Song, Ji Hoon; Lee, Changyeol; Lee, Dahae; Kim, Soonok; Bang, Sunghee; Shin, Myoung-Sook; Lee, Jun; Kang, Ki Sung; Shim, Sang Hee

    2018-05-23

    Colletotrichum sp. JS-0367 was isolated from Morus alba (mulberry), identified, and cultured on a large scale for chemical investigation. One new anthraquinone (1) and three known anthraquinones (2-4) were isolated and identified using spectroscopic methods including 1D/2D-NMR and HRESIMS. Although the neuroprotective effects of some anthraquinones have been reported, the biological activities of the four anthraquinones isolated in this study have not been reported. Therefore, the neuroprotective effects of these compounds were determined against murine hippocampal HT22 cell death induced by glutamate. Compound 4, evariquinone, showed strong protective effects against HT22 cell death induced by glutamate by the inhibition of intracellular ROS accumulation and Ca 2+ influx triggered by glutamate. Immunoblot analysis revealed that compound 4 reduced the phosphorylation of MAPKs (JNK, ERK1/2, and p38) induced by glutamate. Furthermore, compound 4 strongly attenuated glutamate-mediated apoptotic cell death.

  19. Mobilā lietotne: "Instagram bilžu plānotājs"

    OpenAIRE

    Cibuļskis, Aigars

    2016-01-01

    Šajā dokumentā ir iekļauta Latvijas Universitātes Datorikas fakultātes kursa “Kvalifikācijas darbs II” (DatZ2049) praktiskā darba ietvaros izstrādātā lietotne “Mobila lietotne “Instagram bilžu plānotājs”” tehniskā dokumentācija, kas ietver programmatūras prasību specifikāciju, datu bāzes un ekrānformu projektējumus. Instagram bilžu plānotājs - ir lietotne Android platformai, kura domāta atvieglot bilžu izlikšanu sociālajā tīklā Instagram, modes blogeriem un mā...

  20. La literatura cubana del 98: paisaje después de la batalla

    OpenAIRE

    Fornet, Jorge; Pontificia Universidad Javeriana, Bogotá

    2014-01-01

    En 1882, con la aparición del poemario que cambió de forma radical la poesía en nuestra lengua, daba los primeros pasos aquel movimiento que, nacido en América, llegaba al clímax con la obra de Rubén Darío. Años después, el venezolano Manuel Díaz Rodríguez se refería a la labor fecundante de España como"retorno de las carabelas". "Por él", agregaba Rodó en 1916, "la ruta de los conquistadores se tornaría del ocaso al naciente". Lo cierto es que, con "Ismaelillo", José Martí inicia el modernis...

  1. Después de… A History of the Transition

    Directory of Open Access Journals (Sweden)

    Elena Blázquez Carretero

    2014-10-01

    Full Text Available Después de… fulfilled an urgent need in its day, being one of the earliest attempts to reflect the reality of the Transition. This double documentary by the Bartolomé siblings was shot in 1979 and 1980, and approaches various sectors of Spanish society, allowing them to express their points of view, and to discuss and explain how they were affected by the changes that took place following the death of Franco. After 23-F, the attempted coup d’état, the documentary was left stranded by the Administration, falling victim to a covert censorship and to a system of unofficial releases. Perhaps because it brought to light the changes affecting the lives of ordinary people and the stories that had been neglected by the media, the distribution of the documentary was hampered by a great deal of delay and uncertainty. Despite all the difficulties involved in its screening, the testimonies contained in this documentary now provide very useful insight into the problems of the era and those that remain to this day.

  2. Visualization of protein sequence features using JavaScript and SVG with pViz.js.

    Science.gov (United States)

    Mukhyala, Kiran; Masselot, Alexandre

    2014-12-01

    pViz.js is a visualization library for displaying protein sequence features in a Web browser. By simply providing a sequence and the locations of its features, this lightweight, yet versatile, JavaScript library renders an interactive view of the protein features. Interactive exploration of protein sequence features over the Web is a common need in Bioinformatics. Although many Web sites have developed viewers to display these features, their implementations are usually focused on data from a specific source or use case. Some of these viewers can be adapted to fit other use cases but are not designed to be reusable. pViz makes it easy to display features as boxes aligned to a protein sequence with zooming functionality but also includes predefined renderings for secondary structure and post-translational modifications. The library is designed to further customize this view. We demonstrate such applications of pViz using two examples: a proteomic data visualization tool with an embedded viewer for displaying features on protein structure, and a tool to visualize the results of the variant_effect_predictor tool from Ensembl. pViz.js is a JavaScript library, available on github at https://github.com/Genentech/pviz. This site includes examples and functional applications, installation instructions and usage documentation. A Readme file, which explains how to use pViz with examples, is available as Supplementary Material A. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Blood group genotyping for Jk(a)/Jk(b), Fy(a)/Fy(b), S/s, K/k, Kp(a)/Kp(b), Js(a)/Js(b), Co(a)/Co(b), and Lu(a)/Lu(b) with microarray beads.

    Science.gov (United States)

    Karpasitou, Katerina; Drago, Francesca; Crespiatico, Loretta; Paccapelo, Cinzia; Truglio, Francesca; Frison, Sara; Scalamogna, Mario; Poli, Francesca

    2008-03-01

    Traditionally, blood group typing has been performed with serologic techniques, the classical method being the hemagglutination test. Serotyping, however, may present important limitations such as scarce availability of rare antisera, typing of recently transfused patients, and those with a positive direct antiglobulin test. Consequently, serologic tests are being complemented with molecular methods. The aim of this study was to develop a low-cost, high-throughput method for large-scale genotyping of red blood cells (RBCs). Single-nucleotide polymorphisms associated with some clinically important blood group antigens, as well as with certain rare blood antigens, were evaluated: Jk(a)/Jk(b), Fy(a)/Fy(b), S/s, K/k, Kp(a)/Kp(b), Js(a)/Js(b), Co(a)/Co(b), and Lu(a)/Lu(b). Polymerase chain reaction (PCR)-amplified targets were detected by direct hybridization to microspheres coupled to allele-specific oligonucleotides. Cutoff values for each genotype were established with phenotyped and/or genotyped samples. The method was validated with a blind panel of 92 blood donor samples. The results were fully concordant with those provided by hemagglutination assays and/or sequence-specific primer (SSP)-PCR. The method was subsequently evaluated with approximately 800 blood donor and patient samples. This study presents a flexible, quick, and economical method for complete genotyping of large donor cohorts for RBC alleles.

  4. Hipotermia para la neuroprotección en adultos después de la reanimación cardiopulmonar

    Directory of Open Access Journals (Sweden)

    Jasmin Arrich

    2011-05-01

    Conclusiones de los autores: Los métodos de enfriamiento convencional para inducir la hipotermia terapéutica leve parecen mejorar la supervivencia y el estado neurológico después de un paro cardíaco. Esta revisión apoya la mejor práctica médica actual recomendada por las International Resuscitation Guidelines (Guías internacionales de reanimación.

  5. ImageJS: Personalized, participated, pervasive, and reproducible image bioinformatics in the web browser

    Directory of Open Access Journals (Sweden)

    Jonas S Almeida

    2012-01-01

    Full Text Available Background: Image bioinformatics infrastructure typically relies on a combination of server-side high-performance computing and client desktop applications tailored for graphic rendering. On the server side, matrix manipulation environments are often used as the back-end where deployment of specialized analytical workflows takes place. However, neither the server-side nor the client-side desktop solution, by themselves or combined, is conducive to the emergence of open, collaborative, computational ecosystems for image analysis that are both self-sustained and user driven. Materials and Methods: ImageJS was developed as a browser-based webApp, untethered from a server-side backend, by making use of recent advances in the modern web browser such as a very efficient compiler, high-end graphical rendering capabilities, and I/O tailored for code migration. Results : Multiple versioned code hosting services were used to develop distinct ImageJS modules to illustrate its amenability to collaborative deployment without compromise of reproducibility or provenance. The illustrative examples include modules for image segmentation, feature extraction, and filtering. The deployment of image analysis by code migration is in sharp contrast with the more conventional, heavier, and less safe reliance on data transfer. Accordingly, code and data are loaded into the browser by exactly the same script tag loading mechanism, which offers a number of interesting applications that would be hard to attain with more conventional platforms, such as NIH′s popular ImageJ application. Conclusions : The modern web browser was found to be advantageous for image bioinformatics in both the research and clinical environments. This conclusion reflects advantages in deployment scalability and analysis reproducibility, as well as the critical ability to deliver advanced computational statistical procedures machines where access to sensitive data is controlled, that is, without

  6. ImageJS: Personalized, participated, pervasive, and reproducible image bioinformatics in the web browser.

    Science.gov (United States)

    Almeida, Jonas S; Iriabho, Egiebade E; Gorrepati, Vijaya L; Wilkinson, Sean R; Grüneberg, Alexander; Robbins, David E; Hackney, James R

    2012-01-01

    Image bioinformatics infrastructure typically relies on a combination of server-side high-performance computing and client desktop applications tailored for graphic rendering. On the server side, matrix manipulation environments are often used as the back-end where deployment of specialized analytical workflows takes place. However, neither the server-side nor the client-side desktop solution, by themselves or combined, is conducive to the emergence of open, collaborative, computational ecosystems for image analysis that are both self-sustained and user driven. ImageJS was developed as a browser-based webApp, untethered from a server-side backend, by making use of recent advances in the modern web browser such as a very efficient compiler, high-end graphical rendering capabilities, and I/O tailored for code migration. Multiple versioned code hosting services were used to develop distinct ImageJS modules to illustrate its amenability to collaborative deployment without compromise of reproducibility or provenance. The illustrative examples include modules for image segmentation, feature extraction, and filtering. The deployment of image analysis by code migration is in sharp contrast with the more conventional, heavier, and less safe reliance on data transfer. Accordingly, code and data are loaded into the browser by exactly the same script tag loading mechanism, which offers a number of interesting applications that would be hard to attain with more conventional platforms, such as NIH's popular ImageJ application. The modern web browser was found to be advantageous for image bioinformatics in both the research and clinical environments. This conclusion reflects advantages in deployment scalability and analysis reproducibility, as well as the critical ability to deliver advanced computational statistical procedures machines where access to sensitive data is controlled, that is, without local "download and installation".

  7. Cartagena veintiún años después de ser declarada patrimonio mundial

    Directory of Open Access Journals (Sweden)

    Alberto Samudio Trallero

    2007-01-01

    Full Text Available Esta ponencia reconstruye, en primer lugar, un breve recuento de la evolución urbana del centro histórico de Cartagena de Indias, a partir de las primeras décadas del siglo XX, cuando se inicia su recuperación después de un largo período de decadencia ocasionado por el sitio de Pablo Morillo, la guerra de independencia, los conflictos civiles y la incomunicación con el interior del país por el cierre del Canal del Dique. Se producen las primeras manifestaciones de que la ciudad y sus autoridades han tomado conciencia de la importancia de la conservación de su patrimonio monumental. En segundo lugar, en retrospectiva, realiza una mirada a la legislación que respaldó y promovió la labor de conservación del patrimonio urbano y arquitectónico de Cartagena. Posteriormente, en tercer lugar, cuenta cómo comenzó la labor de recuperación de las viejas casonas de los períodos colonial y republicano y su acondicionamiento para nuevos usos. Después, en cuarto lugar, analiza la inclusión de Cartagena en la Lista del Patrimonio Mundial y las consecuencias de esta acción. En último lugar, el autor muestra el panorama de la situación actual, bajo una fuerte presión provocada por la demanda inmobiliaria y las posibles repercusiones de orden socioeconómico, urbanístico y ambiental.

  8. The maintenance and the radiological safety in gamma irradiation facilities; El mantenimiento y la seguridad radiologica en instalaciones de irradiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Torres C, G [Gerencia de Servicios Tecnicos Nucleares ININ (Mexico)

    1991-07-01

    Presently work the outstanding aspects of the operation and maintenance of the Industrial Irradiator JS 6500 are described that the ININ operates, in the Nuclear Center of Salazar, Estado de Mexico and its relationship with the radiological security for the occupationally exposed personnel. The signal devices are described and of control of the associate teams, as the system of cooling of the source; the plant of treatment of water of the pool and the system of extraction of ozone. On the other hand the procedures are mentioned for the sure operation and the application of the annual programs of maintenance, in their aspects of more interest, to reduce to the maximum the correction of faults, during the routine operation.

  9. Design of device for testing in the gamma irradiator

    International Nuclear Information System (INIS)

    Mariano H, E.

    1991-02-01

    In eves of the recharge of the Gamma Irradiator, JS-6500 it was detected, that there was contamination in the container that housed the pencils of Co-60, coming from Argentina, country to which the ININ buys it recharges. It was determined that the contamination in the container was it interns and after discussing several solution options it was determined to manufacture a device to make a washing of the pencils. It was touch to the Management of Radiological Safety to determine the conceptual design of the device to make the washing and the way of operation of the same one. The Management of Prototypes and Models was responsibility of the mechanical design and its production. (Author)

  10. The maintenance and the radiological safety in gamma irradiation facilities

    International Nuclear Information System (INIS)

    Torres C, G.

    1991-01-01

    Presently work the outstanding aspects of the operation and maintenance of the Industrial Irradiator JS 6500 are described that the ININ operates, in the Nuclear Center of Salazar, Estado de Mexico and its relationship with the radiological security for the occupationally exposed personnel. The signal devices are described and of control of the associate teams, as the system of cooling of the source; the plant of treatment of water of the pool and the system of extraction of ozone. On the other hand the procedures are mentioned for the sure operation and the application of the annual programs of maintenance, in their aspects of more interest, to reduce to the maximum the correction of faults, during the routine operation

  11. The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species.

    Science.gov (United States)

    Maciag, Anna E; Chakrapani, Harinath; Saavedra, Joseph E; Morris, Nicole L; Holland, Ryan J; Kosak, Ken M; Shami, Paul J; Anderson, Lucy M; Keefer, Larry K

    2011-02-01

    Non-small-cell lung cancer is among the most common and deadly forms of human malignancies. Early detection is unusual, and there are no curative therapies in most cases. Diazeniumdiolate-based nitric oxide (NO)-releasing prodrugs are a growing class of promising NO-based therapeutics. Here, we show that O(2)-(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) is a potent cytotoxic agent against a subset of human non-small-cell lung cancer cell lines both in vitro and as xenografts in mice. JS-K treatment led to 75% reduction in the growth of H1703 lung adenocarcinoma cells in vivo. Differences in sensitivity to JS-K in different lung cancer cell lines seem to be related to their endogenous levels of reactive oxygen species (ROS)/reactive nitrogen species (RNS). Other related factors, levels of peroxiredoxin 1 (PRX1) and 8-oxo-deoxyguanosine glycosylase (OGG1), also correlated with drug sensitivity. Treatment of the lung adenocarcinoma cells with JS-K resulted in oxidative/nitrosative stress in cells with high basal levels of ROS/RNS, which, combined with the arylating properties of the compound, was reflected in glutathione depletion and alteration in cellular redox potential, mitochondrial membrane permeabilization, and cytochrome c release. Inactivation of manganese superoxide dismutase by nitration was associated with increased superoxide and significant DNA damage. Apoptosis followed these events. Taken together, the data suggest that diazeniumdiolate-based NO-releasing prodrugs may have application as a personalized therapy for lung cancers characterized by high levels of ROS/RNS. PRX1 and OGG1 proteins, which can be easily measured, could function as biomarkers for identifying tumors sensitive to the therapy.

  12. [Application of multiplex PCR for the screening of genotyping system for the rare blood groups Fy(a-), s-,k-,Di(b-) and Js(b-)].

    Science.gov (United States)

    Jiao, Wei; Xie, Li; Li, Hailan; Lan, Jiao; Mo, Zhuning; Yang, Ziji; Liu, Fei; Xiao, Ruiping; He, Yunlei; Ye, Luyi; Zhu, Ziyan

    2014-04-01

    To screen rare blood groups Fy(a-), s-, k-, Di(b-) and Js(b-) in an ethnic Zhuang population. Sequence-specific primers were designed based on single nucleotide polymorphism (SNP) sites of blood group antigens Fy(b) and s. A specific multiplex PCR system I was established. Multiplex PCR system II was applied to detect alleles antigens Di(b), k, Js(b)1910 and Js(b) 2019 at the same time. The two systems was were used to screen for rare blood group antigens in 4490 randomly selected healthy donors of Guangxi Zhuang ethnic origin. We successfully made the multiplex PCR system I. We detected the rare blood group antigens using the two PCR system. There are five Fy(a-), three s(-), two Di(b-) in 4490 Guangxi zhuang random samples. The multiplex PCR system I has achieved good accuracy and stability. With multiplex PCR systems I and II, 4490 samples were screened. Five Fy(a-), three s(-) and two Di(b-) samples were discovered. Multiplex PCR is an effective methods, which can be used for high throughput screening of rare blood groups. The rare blood types of Guangxi Zhuang ethnic origin obtained through the screening can provide valuable information for compatible blood transfusion. Through screening we obtained precious rare blood type materials which can be used to improve the capability of compatible infusion and reduce the transfusion reactions.

  13. Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.

    Science.gov (United States)

    Kumar, Varun; Hong, Sam Y; Maciag, Anna E; Saavedra, Joseph E; Adamson, Douglas H; Prud'homme, Robert K; Keefer, Larry K; Chakrapani, Harinath

    2010-02-01

    We report the stabilization of the nitric oxide (NO) prodrugs and anticancer lead compounds, PABA/NO (O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate) and "Double JS-K" 1,5-bis-{1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diol-2-ato}-2,4-dinitrobenzene, through their incorporation into polymer-protected nanoparticles. The prodrugs were formulated in block copolymer-stabilized nanoparticles with sizes from 220 to 450 nm by a novel rapid precipitation process. The block copolymers, with polyethylene glycol (PEG) soluble blocks, provide a steric barrier against NO prodrug activation by glutathione. Too rapid activation and NO release has been a major barrier to effective administration of this class of compounds. The nanoparticle stabilized PABA/NO are protected from attack by glutathione as evidenced by a significant increase in time taken for 50% decomposition from 15 min (unformulated) to 5 h (formulated); in the case of Double JS-K, the 50% decomposition time was extended from 4.5 min (unformulated) to 40 min (formulated). The more hydrophobic PABA/NO produced more stable nanoparticles and correspondingly more extended release times in comparison with Double JS-K. The hydrophobic blocks of the polymer were either polystyrene or polylactide. Both blocks produced nanoparticles of approximately the same size and release kinetics. This combination of PEG-protected nanoparticles with sizes appropriate for cancer targeting by enhanced permeation and retention (EPR) and delayed release of NO may afford enhanced therapeutic benefit.

  14. Sobre la píldora del día después: aspectos a tener en cuenta

    OpenAIRE

    De la Rubia Comos JM.

    2012-01-01

    En el número anterior de nuestra revista, apareció un completo e interesante artículo de nuestra compañera Mª Jesús Rodríguez Martínez1 sobre la anticoncepción desde la farmacia comunitaria. Por este motivo me ha pare cido interesante hacer hincapié en la conocida como Píldora Postcoital, Píldora del Día Siguiente o Píldora del Día Después (PDD).

  15. The Nitric Oxide Prodrug JS-K Is Effective against Non–Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen SpeciesS⃞

    Science.gov (United States)

    Chakrapani, Harinath; Saavedra, Joseph E.; Morris, Nicole L.; Holland, Ryan J.; Kosak, Ken M.; Shami, Paul J.; Anderson, Lucy M.; Keefer, Larry K.

    2011-01-01

    Non–small-cell lung cancer is among the most common and deadly forms of human malignancies. Early detection is unusual, and there are no curative therapies in most cases. Diazeniumdiolate-based nitric oxide (NO)-releasing prodrugs are a growing class of promising NO-based therapeutics. Here, we show that O2-(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) is a potent cytotoxic agent against a subset of human non–small-cell lung cancer cell lines both in vitro and as xenografts in mice. JS-K treatment led to 75% reduction in the growth of H1703 lung adenocarcinoma cells in vivo. Differences in sensitivity to JS-K in different lung cancer cell lines seem to be related to their endogenous levels of reactive oxygen species (ROS)/reactive nitrogen species (RNS). Other related factors, levels of peroxiredoxin 1 (PRX1) and 8-oxo-deoxyguanosine glycosylase (OGG1), also correlated with drug sensitivity. Treatment of the lung adenocarcinoma cells with JS-K resulted in oxidative/nitrosative stress in cells with high basal levels of ROS/RNS, which, combined with the arylating properties of the compound, was reflected in glutathione depletion and alteration in cellular redox potential, mitochondrial membrane permeabilization, and cytochrome c release. Inactivation of manganese superoxide dismutase by nitration was associated with increased superoxide and significant DNA damage. Apoptosis followed these events. Taken together, the data suggest that diazeniumdiolate-based NO-releasing prodrugs may have application as a personalized therapy for lung cancers characterized by high levels of ROS/RNS. PRX1 and OGG1 proteins, which can be easily measured, could function as biomarkers for identifying tumors sensitive to the therapy. PMID:20962031

  16. Solution strengthened ferritic ductile iron ISO 1083/JS/500-10 provides superior consistent properties in hydraulic rotators

    Directory of Open Access Journals (Sweden)

    Dr. Richard Larker

    2009-11-01

    Full Text Available Consistent mechanical and machining properties are essential in many applications where ductile irons offer the most cost-effective way to produce structural parts. In the production of hydraulic rotators, dimensional tolerances are typically 20 μm to obtain designated performance. For castings where intermediate strength and ductility is required, it is common knowledge that conventional ferritic-pearlitic ductile irons such as ISO 1083/500-7 show large hardness variations. These are mainly caused by the notoriously varying pearlite content, both at different locations within a part and between parts in the same or different batches. Cooling rate variations due to different wall thickness and position in the molding box, as well as varying amounts of pearlite-stabilizing elements, all contribute to detrimental hardness variations. The obvious remedy is to avoid pearlite formation, and instead obtain the necessary mechanical properties by solution strengthening of the ferritic matrix by increasing silicon content to 3.7wt% –3.8wt%. The Swedish development in this fi eld 1998 resulted in a national standardization as SS 140725, followed in 2004 by ISO 1083/JS/500-10. Indexator AB decided 2005 to specify JS/500-10 for all new ductile iron parts and to convert all existing parts. Improvements include reduction by 75% in hardness variations and increase by 30% in cutting tool life, combined with consistently better mechanical properties.

  17. jsPhyloSVG: a javascript library for visualizing interactive and vector-based phylogenetic trees on the web.

    Science.gov (United States)

    Smits, Samuel A; Ouverney, Cleber C

    2010-08-18

    Many software packages have been developed to address the need for generating phylogenetic trees intended for print. With an increased use of the web to disseminate scientific literature, there is a need for phylogenetic trees to be viewable across many types of devices and feature some of the interactive elements that are integral to the browsing experience. We propose a novel approach for publishing interactive phylogenetic trees. We present a javascript library, jsPhyloSVG, which facilitates constructing interactive phylogenetic trees from raw Newick or phyloXML formats directly within the browser in Scalable Vector Graphics (SVG) format. It is designed to work across all major browsers and renders an alternative format for those browsers that do not support SVG. The library provides tools for building rectangular and circular phylograms with integrated charting. Interactive features may be integrated and made to respond to events such as clicks on any element of the tree, including labels. jsPhyloSVG is an open-source solution for rendering dynamic phylogenetic trees. It is capable of generating complex and interactive phylogenetic trees across all major browsers without the need for plugins. It is novel in supporting the ability to interpret the tree inference formats directly, exposing the underlying markup to data-mining services. The library source code, extensive documentation and live examples are freely accessible at www.jsphylosvg.com.

  18. Complete Genome Sequences of Porcine Epidemic Diarrhea Virus Strains JSLS-1/2015 and JS-2/2015 Isolated from China.

    Science.gov (United States)

    Tao, Jie; Li, Benqiang; Zhang, Chunling; Liu, Huili

    2016-11-10

    Two porcine epidemic diarrhea virus (PEDV) strains, JSLS-1/2015 and JS-2/2015, were isolated from piglets with watery diarrhea in South China. Two genomic sequences were highly homologous to the attenuated DR13 strain. Furthermore, JSLS-1/2015 contains a 24-amino-acid deletion in open reading frame 1b, which was first reported in PEDV isolates. Copyright © 2016 Tao et al.

  19. Draft Genome Sequence of an Endophytic Fungus, Gaeumannomyces sp. Strain JS-464, Isolated from a Reed Plant, Phragmites communis.

    Science.gov (United States)

    Kim, Jung A; Jeon, Jongbum; Kim, Ki-Tae; Choi, Gobong; Park, Sook-Young; Lee, Hyun-Jung; Shim, Sang-Hee; Lee, Yong-Hwan; Kim, Soonok

    2017-08-03

    An endophytic fungus, Gaeumannomyces sp. strain JS-464, is capable of producing a number of secondary metabolites which showed significant nitric oxide reduction activity. The draft genome assembly has a size of 53,151,282 bp, with a G+C content of 53.11% consisting of 80 scaffolds with an N 50 of 7.46 Mbp. Copyright © 2017 Kim et al.

  20. Characterization Problem (Troubleshooting) for IR219 Irradiator, JS10000 in Mintec-SINAGAMA: The Partnership

    International Nuclear Information System (INIS)

    Shahidan Yob; Nor Ishadi Ismail; Kamarudin Buyong

    2015-01-01

    Control of the fuel-efficient plant operations are key to gamma irradiation service in MINTec-Sinagama. Without an efficient operation, irradiation services will be disrupted and lead to customer product failed to be completed in a set time. Additionally, downtime each time operation is also important to monitor to ensure that the fuel-efficient plant exceeded 85% in each month. In this paper MINTec plant operations data collection-Sinagama made during the year 2011-2015. Analysis carried out against downtime, the extent of damage and the action according to the classification of plant problems. This data collection is important for pattern characterization solution that can be made to the irradiator IR219, JS10000 in MINTec-Sinagama. (author)

  1. Sobre la píldora del día después: aspectos a tener en cuenta

    Directory of Open Access Journals (Sweden)

    De la Rubia Comos JM.

    2012-06-01

    Full Text Available En el número anterior de nuestra revista, apareció un completo e interesante artículo de nuestra compañera Mª Jesús Rodríguez Martínez1 sobre la anticoncepción desde la farmacia comunitaria. Por este motivo me ha pare cido interesante hacer hincapié en la conocida como Píldora Postcoital, Píldora del Día Siguiente o Píldora del Día Después (PDD.

  2. La ingesta de hidratos de carbono, antes, durante y después de una competencia deportiva

    OpenAIRE

    Abrines, María de la Candelaria

    2015-01-01

    Las competencias del running se realizan a lo largo del año y requieren de un cuidadoso plan nutricional que permita disponer de los nutrientes necesarios y recuperarlos al finalizarla. Objetivo: Determinar la ingesta de hidratos de carbono, antes, durante y después de una competencia deportiva, su adecuación a las recomendaciones y la recuperación de la fatiga post-competencia en corredores amateurs de 20 a 65 años de ambos sexos de la ciudad de Mar del Plata que participan de ...

  3. Modificaciones en la composición corporal después de realizar una prueba de ultrarresistencia de 1.700 km en bicicleta de montaña

    OpenAIRE

    Vicente Clemente Suárez; José María González-Ravé

    2010-01-01

    El estudio de los cambios en la composición corporal en pruebas de resistencia se ha limitado en la mayoría de los casos al estudio de las pérdidas de peso corporal. El presente estudio pretende analizar los cambios producidos en la composición corporal (agua, proteínas, minerales, grasa, y músculo) producidos después de realizar una prueba de 1.700 Km en bicicleta de montaña cruzando África de este a oeste. Se analizaron 5 sujetos (73,3±10,2 kg, 170±0,1 cm, 51,2±6,9 años) antes y después de ...

  4. Ataxia cerebelosa persistente despues de la administracion toxica de difenilhidantoina

    Directory of Open Access Journals (Sweden)

    Andrés M. Villa

    1994-12-01

    Full Text Available La intoxicacion cronica con difenilhidantoina (DFH es bien conocida como causa de ataxia irreversible en pacientes epilépticos debida a atrofia cerebelosa con perdida de células de Purkinje. No es asi con la intoxicación aguda, puesto que sus signos y síntomas son reversibles. Presentamos un paciente con convulsiones parciales complejas, secundarias a un quiste temporal, que habia sido tratado irregularmente con DFH durante dos años con dosis variables que oscilaban en los 100 mg/dia. Dada la refractariedad de su cuadro convulsivo en una entrevista previa a su ingreso se le indico un aumento brusco de la dosis del fármaco que alcanzo a los 400 mg/dia. Ello ocasiono un sindrome pancerebeloso severo que motivo su internación. Posteriormente a la suspension de la DFH y la exeresis del quiste temporal mejoro su cuadro convulsivo, aunque quedo con ataxia de miembros inferiores y asinergia de tronco, cuadro con el que fue dado de alta. Un año despues, el paciente se encontraba libre de convulsiones, pero su sindrome cerebeloso no se habia modificado. El estudio por imágenes no evidencio atrofia cerebelosa.

  5. FeatureViewer, a BioJS component for visualization of position-based annotations in protein sequences [v1; ref status: indexed, http://f1000r.es/2u2

    Directory of Open Access Journals (Sweden)

    Leyla Garcia

    2014-02-01

    Full Text Available Summary: FeatureViewer is a BioJS component that lays out, maps, orients, and renders position-based annotations for protein sequences. This component is highly flexible and customizable, allowing the presentation of annotations by rows, all centered, or distributed in non-overlapping tracks. It uses either lines or shapes for sites and rectangles for regions. The result is a powerful visualization tool that can be easily integrated into web applications as well as documents as it provides an export-to-image functionality. Availability: https://github.com/biojs/biojs/blob/master/src/main/javascript/Biojs.FeatureViewer.js; http://dx.doi.org/10.5281/zenodo.7719

  6. Ivona Březinová y sus Locos quijotes tras las huellas literarias del Quijote y su autor 404 años después

    Directory of Open Access Journals (Sweden)

    Cristina Simón Alegre

    2012-12-01

    Full Text Available En 2009 la escritora checa Ivona Březinová decidió traer de vuelta a un personaje literario que ha penetrado en todos los rincones del planeta: el valeroso y entraňable don Quijote de la Mancha. Su propósito continúa en su empeño por resucitar décadas o siglos después obras inmortales que a pesar de haber pasado a formar parte del cánon literario hace mucho tiempo y de forma indiscutible, siguen siendo una fuente inagotable para los lectores de todos los tiempos. Con su novela Blázniví donkichoti (Los locos donquijotes, la autora reaviva al personaje más célebre de los surgidos de la pluma de Cervantes. En esta obra literaria juega con el paso del tiempo y cómo éste no cambia el carácter inagotable de autor y su obra. Esta novela es una excursión literaria actual a la España del Quijote que la autora nos propone muchos siglos después de que saliese a la luz todo un universo literario que un grupo de cinco jóvenes de la República Checa se atreve a descubrir sumergiéndose hasta tal punto en las huellas vivas de Cervantes y su Quijote, que consigue 404 años después identificarse y mimetizarse con las vivencias del autor y el protagonista de su obra.

  7. Letter regarding Li JS et al. entitled "ERCC polymorphisms and prognosis of patients with osteosarcoma".

    Science.gov (United States)

    Jian, Yuekui; Tian, Xiaobin; Li, Bo; Zhou, Zhuojia; Wu, Xinglin

    2015-05-01

    With great interest, we read the article "ERCC polymorphisms and prognosis of patients with osteosarcoma" (by Li JS et al.), which has reached important conclusions about the relationship between ERCC polymorphisms and osteosarcoma prognosis. Through quantitative analysis, the meta-analysis showed that ERCC2 Lys751Gln (ORGG vs. AA = 0.40 (95%CI = 0.1-0.86), P heterogeneity = 0.502; I (2) = 0 %) and ERCC5 His46His (ORCC vs. TT = 0.37 (95%CI = 0.15-0.93), P heterogeneity = 0.569; I (2) = 0 %) polymorphisms might influence the prognosis of patients with osteosarcoma [1]. The meta-analysis results are encouraging. Nevertheless, some deficiencies still existed that we would like to raise.

  8. CerebralWeb: a Cytoscape.js plug-in to visualize networks stratified by subcellular localization.

    Science.gov (United States)

    Frias, Silvia; Bryan, Kenneth; Brinkman, Fiona S L; Lynn, David J

    2015-01-01

    CerebralWeb is a light-weight JavaScript plug-in that extends Cytoscape.js to enable fast and interactive visualization of molecular interaction networks stratified based on subcellular localization or other user-supplied annotation. The application is designed to be easily integrated into any website and is configurable to support customized network visualization. CerebralWeb also supports the automatic retrieval of Cerebral-compatible localizations for human, mouse and bovine genes via a web service and enables the automated parsing of Cytoscape compatible XGMML network files. CerebralWeb currently supports embedded network visualization on the InnateDB (www.innatedb.com) and Allergy and Asthma Portal (allergen.innatedb.com) database and analysis resources. Database tool URL: http://www.innatedb.com/CerebralWeb © The Author(s) 2015. Published by Oxford University Press.

  9. Microdureza de caries incipientes artificiales infiltradas con resinas de baja viscosidad antes y después del termociclado

    OpenAIRE

    X. Zamorano Pino; V. Valenzuela Aránguiz; C. Vial Prado; M. Vidal Tardón

    2015-01-01

    Introducción: En Odontología Mínimamente Invasiva, el procedimiento denominado Infiltración de caries, pretende detener la progresión de las caries incipientes mediante el sellado de las microporosidades del esmalte afectado. Este tratamiento se realiza con la aplicación de resinas de baja viscosidad. El objetivo de este trabajo fue evaluar la microdureza superficial de caries incipientes artificiales infiltradas con resinas de baja viscosidad antes y después del proceso de termociclado. Meto...

  10. Evaluación del estrés y el impacto de la fibromialgia después de autoaplicar técnicas cognitivo-conductuales

    Directory of Open Access Journals (Sweden)

    Mónica Teresa González-Ramírez

    2010-01-01

    Full Text Available Se diseñaron dos cursos virtuales auto-aplicados para personas con fibromialgia, basados en técnicas cognitivo-conductuales. Los objetivos fueron, (1 Evaluar los resultados del primer curso sobre estrés percibido e impacto de la fibromialgia. (2 Evaluar los resultados del segundo curso, en la disminución de, fallos cotidianos de memoria, pensamientos negativos, catastrofización, e impacto de la fibromialgia. Y (3 comparar niveles de estrés e impacto en las cuatro mediciones (pre-post, ambos cursos. Participaron 22 mujeres en el primero y 8 en el segundo. Se encontró mejoría en estrés percibido e impacto de la fibromialgia después del primer curso. Después del segundo disminuyeron: pensamientos negativos, catastrofización e impacto. Hubo una recaída en el estrés y el impacto entre ambos cursos disminuyendo nuevamente al concluir el segundo.

  11. 3D Planetary Data Visualization with CesiumJS

    Science.gov (United States)

    Larsen, K. W.; DeWolfe, A. W.; Nguyen, D.; Sanchez, F.; Lindholm, D. M.

    2017-12-01

    Complex spacecraft orbits and multi-instrument observations can be challenging to visualize with traditional 2D plots. To facilitate the exploration of planetary science data, we have developed a set of web-based interactive 3D visualizations for the MAVEN and MMS missions using the free CesiumJS library. The Mars Atmospheric and Volatile Evolution (MAVEN) mission has been collecting data at Mars since September 2014. The MAVEN3D project allows playback of one day's orbit at a time, displaying the spacecraft's position and orientation. Selected science data sets can be overplotted on the orbit track, including vectors for magnetic field and ion flow velocities. We also provide an overlay the M-GITM model on the planet itself. MAVEN3D is available at the MAVEN public website at: https://lasp.colorado.edu/maven/sdc/public/pages/maven3d/ The Magnetospheric MultiScale Mission (MMS) consists of one hundred instruments on four spacecraft flying in formation around Earth, investigating the interactions between the solar wind and Earth's magnetic field. While the highest temporal resolution data isn't received and processed until later, continuous daily observations of the particle and field environments are made available as soon as they are received. Traditional `quick-look' static plots have long been the first interaction with data from a mission of this nature. Our new 3D Quicklook viewer allows data from all four spacecraft to be viewed in an interactive web application as soon as the data is ingested into the MMS Science Data Center, less than one day after collection, in order to better help identify scientifically interesting data.

  12. Los Derechos Humanos Después del 11 de Septiembre

    Directory of Open Access Journals (Sweden)

    Jean Paul Marthoz

    2003-01-01

    Full Text Available La guerra con tra el terrorismo marca un cambio de paradigma y la afirmación de otra cosmovisión. Ciertos vaticinan que la democracia, tal como se vivía o se soñaba después del derrumbe del comunismo soviético, ha llegado a un peak y que el 11 de septiembre ha detenido el avance que se creía ir re vers ible del imperio de la ley y del derecho en el concierto de las naciones. La proliferación de medidas restrictivas o represivas, el recurso a la fraseología y la lógica de la guerra, el endurecimiento de una opinión pública angustiada e insegura, el re torno al discurso de la re al po li tik, han debilitado el movimiento de los derechos humanos, fragilizado sus argumentaciones y marginado sus acciones. Las ONG’s de derechos humanos tienen que acordarse que la batalla por los derechos no se hace únicamente sobre el terreno le gal y con las armas del derecho internacional. La lucha por los derechos humanos es también una batalla política, es decir, intelectual, que implica desarrollar cuadros interpretativos del mundo.

  13. Biomimetic synthesis of selenium nanospheres by bacterial strain JS-11 and its role as a biosensor for nanotoxicity assessment: a novel se-bioassay.

    Science.gov (United States)

    Dwivedi, Sourabh; Alkhedhairy, Abdulaziz A; Ahamed, Maqusood; Musarrat, Javed

    2013-01-01

    Selenium nanoparticles (Se-NPs) were synthesized by green technology using the bacterial isolate Pseudomonas aeruginosa strain JS-11. The bacteria exhibited significant tolerance to selenite (SeO3(2-)) up to 100 mM concentration with an EC50 value of 140 mM. The spent medium (culture supernatant) contains the potential of reducing soluble and colorless SeO3(2-) to insoluble red elemental selenium (Se(0)) at 37°C. Characterization of red Se° product by use of UV-Vis spectroscopy, X-ray diffraction (XRD), atomic force microscopy (AFM) and transmission electron microscopy (TEM) with energy dispersive X-ray spectrum (EDX) analysis revealed the presence of stable, predominantly monodispersed and spherical selenium nanoparticles (Se-NPs) of an average size of 21 nm. Most likely, the metabolite phenazine-1-carboxylic acid (PCA) released by strain JS-11 in culture supernatant along with the known redox agents like NADH and NADH dependent reductases are responsible for biomimetic reduction of SeO3(2-) to Se° nanospheres. Based on the bioreduction of a colorless solution of SeO3(2-) to elemental red Se(0), a high throughput colorimetric bioassay (Se-Assay) was developed for parallel detection and quantification of nanoparticles (NPs) cytotoxicity in a 96 well format. Thus, it has been concluded that the reducing power of the culture supernatant of strain JS-11 could be effectively exploited for developing a simple and environmental friendly method of Se-NPs synthesis. The results elucidated that the red colored Se° nanospheres may serve as a biosensor for nanotoxicity assessment, contemplating the inhibition of SeO3(2-) bioreduction process in NPs treated bacterial cell culture supernatant, as a toxicity end point.

  14. Nota sobre la semántica de la expresión «Iglesia católica» antes y después del ‘Edicto’ de Constantino del 313

    OpenAIRE

    Grossi, V. (Vittorino)

    2013-01-01

    En la presente investigación intentamos llegar al núcleo de la comprensión del concepto «Iglesia católica » antes y después del llamado ‘edicto de Constantino’ que, en la historia de la religión ristiana, marcó un antes y un después del 313. Antes de esa fecha el significado de Iglesia ‘católica’ se utilizaba sólo en el ámbito religioso cristiano; a partir del ‘edicto’ del 313 en adelante, se desarrollaron, mezclándose, dos significados del término «católica», uno –podríamos llamar ha...

  15. Antes y después de El Suicidio: Presentación de dos textos de Durkheim

    OpenAIRE

    Ramos Torre, Ramón

    1998-01-01

    Publicado en 1897, El Suicidio (SU) tiene un antes y un después en la obra de Durkheim. Los dos pequeños trabajos que aquí se presentan permiten abocetar esa historia. El primero es como un prólogo inmaduro a SU. Su lectura permite calibrar más adecuadamente el carácter ruptural e innovador de la monografía de 1897 no sólo en el panorama general de la indagación sociológica, sino también en la propia biografía intelectual de Durkheim. El segundo texto, más circunscrito, centrado en el proble...

  16. Using Paleoecology to Inform Land Management as Climates Change: An Example from an Oak Savanna Ecosystem

    Science.gov (United States)

    Spencer, Jessica D.; Brunelle, Andrea; Hepola, Tim

    2017-12-01

    Oak savanna, a transitional ecosystem between open prairie and dense oak forest, was once widespread in Minnesota. Upon European settlement much of the oak savanna was destroyed. Recently, efforts to restore this ecosystem have increased and often include the reintroduction of fire. Though fire is known to serve an important role within oak savannas, there are currently few studies which address fire regimes on timescales longer than the last century. This research presents a paleoecological history of Sherburne National Wildlife Refuge (SNWR) in MN, USA, spanning the last 8000 years. The objectives of this study were to use charcoal, pollen, and magnetic susceptibility of lake sediments collected from Johnson Slough (JS) within the refuge to evaluate the natural range of variability and disturbance history of the oak savanna within the refuge, assess the success of current restoration strategies, and add to the regional paleoecological history. The mid/late Holocene period of the JS record shows a period of high fire activity from ca. 6500 to 2600 cal year BP, with a shift from prairie to oak savanna occurring over this same period. A (possibly agricultural) disturbance to JS sediments affected the period from ca. 2600 cal year BP to 1963 AD, which includes the time of Euro-American settlement. However, the destruction and subsequent restoration of the oak savanna is evident in a pollen ratio of Quercus:Poaceae, indicating that current restoration efforts have been successful at restoring the oak savanna to within the natural range of variability seen just prior to destruction.

  17. Antes, durante y después de un incendio forestal (Before, During, and After a Wildfire)

    Centers for Disease Control (CDC) Podcasts

    Cada vez más personas construyen sus hogares en lugares boscosos, ya sea dentro o cerca de bosques, áreas rurales o sitios remotos en las montañas. Estas áreas son más propensas a los incendios forestales. Los incendios forestales a menudo comienzan en forma inadvertida, pero se extienden rápidamente, y prenden a su paso maleza, árboles y casas. Los CDC recomiendan tomar una serie de medidas antes, durante y después de un incendio forestal local, a fin contrarrestar sus efectos negativos.

  18. Iron-Dependent Enzyme Catalyzes the Initial Step in Biodegradation of N-Nitroglycine by Variovorax sp. Strain JS1663.

    Science.gov (United States)

    Mahan, Kristina M; Zheng, Hangping; Fida, Tekle T; Parry, Ronald J; Graham, David E; Spain, Jim C

    2017-08-01

    Nitramines are key constituents of most of the explosives currently in use and consequently contaminate soil and groundwater at many military facilities around the world. Toxicity from nitramine contamination poses a health risk to plants and animals. Thus, understanding how nitramines are biodegraded is critical to environmental remediation. The biodegradation of synthetic nitramine compounds such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been studied for decades, but little is known about the catabolism of naturally produced nitramine compounds. In this study, we report the isolation of a soil bacterium, Variovorax sp. strain JS1663, that degrades N -nitroglycine (NNG), a naturally produced nitramine, and the key enzyme involved in its catabolism. Variovorax sp. JS1663 is a Gram-negative, non-spore-forming motile bacterium isolated from activated sludge based on its ability to use NNG as a sole growth substrate under aerobic conditions. A single gene ( nnlA ) encodes an iron-dependent enzyme that releases nitrite from NNG through a proposed β-elimination reaction. Bioinformatics analysis of the amino acid sequence of NNG lyase identified a PAS (Per-Arnt-Sim) domain. PAS domains can be associated with heme cofactors and function as signal sensors in signaling proteins. This is the first instance of a PAS domain present in a denitration enzyme. The NNG biodegradation pathway should provide the basis for the identification of other enzymes that cleave the N-N bond and facilitate the development of enzymes to cleave similar bonds in RDX, nitroguanidine, and other nitramine explosives. IMPORTANCE The production of antibiotics and other allelopathic chemicals is a major aspect of chemical ecology. The biodegradation of such chemicals can play an important ecological role in mitigating or eliminating the effects of such compounds. N -Nitroglycine (NNG) is produced by the Gram-positive filamentous soil bacterium Streptomyces noursei This study reports the

  19. Evaluation of ductile tearing in a cracked component with a simple method (Js)

    International Nuclear Information System (INIS)

    Moulin, D.; Drubay, B.; Clement, G.; Nedelec, M.

    1995-01-01

    In the nuclear industry, it is more and more usual to perform fracture assessment on detective structures made of ductile material with the help of elastoplastic' fracture mechanics relying on the parameter J. Several engineering methods have been developed in the past to calculate this parameter. These results were used to develop a practical procedure noted Js method which simply gives J as function of elastically calculated Je and a plastic correction factor. This method has been introduced in the A16 rule developed jointly by CEA-EdF and Novatome for fast breeder reactors in particular in order to evaluate the loading at crack instability taking into a account ductile tearing. The determination of initiation has already been presented. This determination of the loading at crack instability is examined through two simple but representative examples using the simplified estimation of J. Predicted loadings at crack instability are compared with experimental results. This study was carried out a part of cooperative program with the Institut de Protection et de Surete Nucleaire of the CEA. (author) 12 refs., 10 figs

  20. Antes, durante y después de un incendio forestal (Before, During, and After a Wildfire)

    Centers for Disease Control (CDC) Podcasts

    2007-11-01

    Cada vez más personas construyen sus hogares en lugares boscosos, ya sea dentro o cerca de bosques, áreas rurales o sitios remotos en las montañas. Estas áreas son más propensas a los incendios forestales. Los incendios forestales a menudo comienzan en forma inadvertida, pero se extienden rápidamente, y prenden a su paso maleza, árboles y casas. Los CDC recomiendan tomar una serie de medidas antes, durante y después de un incendio forestal local, a fin contrarrestar sus efectos negativos.  Created: 11/1/2007 by Emergency Communications System.   Date Released: 4/13/2009.

  1. [113] Discapacidad y construcciones de género en Después del invierno de Guadalupe Nettel

    Directory of Open Access Journals (Sweden)

    Etna Ávalos

    2018-04-01

    Full Text Available In Guadalupe Nettel’s narratives, the representation of disability deconstructs various Latin American paradigms of 'normalcy', within a global context. Drawing primarily from her novel, Después del invierno (2014, this study focuses on the processes that confront the restrictive and oppressive notions of 'the feminine' and 'the masculine'. Following theoretical postulates that define disability as a social construction, as well as contemporary theories on gender and masculinities, this essay seeks to uncover the ways in which the normalization of otherness reveals the elastic and malleable identity of the protagonists. Consequently, the study also traces the reciprocal connection between gender and disability as portrayed in the novel, as well as the social perception of disability.

  2. Building HTML5 games with ImpactJS an introduction on HTML5 game development

    CERN Document Server

    Freeman, Jesse

    2012-01-01

    Create a real 2D game from start to finish with ImpactJS, the JavaScript game framework that works with the HTML5's Canvas element. Making video games is hard work that requires technical skills, a lot of planning, and-most critically-a commitment to completing the project. With this hands-on guide, you'll learn how to use Impact with other technologies step-by-step. You'll pick up important tips about game design, and discover how to publish Impact games to the Web, desktop, and mobile-including a method to package your game as a native iOS app. Packed with screen shots and sample code, this book is ideal for game developers of all levels. Set up your development environment and discover Impact's advantagesBuild a complete game with core logic, collision detection, and player and monster behaviorLearn why a game design document is critical before you start buildingDisplay and animate game artwork with sprite sheetsAdd sound effects, background music, and textCreate screens to display stats and in-game statu...

  3. Crosslinking Protein Glutathionylation Mediated by O2-Arylated Bis-Diazeniumdiolate “Double JS-K”

    Science.gov (United States)

    Holland, Ryan J.; Maciag, Anna E.; Kumar, Varun; Shi, Lei; Saavedra, Joseph E.; Prud’homme, Robert K.; Chakrapani, Harinath; Keefer, Larry K.

    2012-01-01

    Attachment of glutathione (GSH) to cysteine residues in proteins (S-glutathionylation) is a reversible post-translational modification that can profoundly alter protein structure and function. Often serving in a protective role, e.g., by temporarily saving protein thiols from irreversible oxidation and inactivation, glutathionylation can be identified and semi-quantitatively assessed using anti-GSH antibodies, thought to be specific for recognition of the S-glutathionylation modification. Here we describe an alternate mechanism of protein glutathionylation in which the sulfur atoms of the GSH and the protein’s thiol group are covalently bound via a crosslinking agent, rather than through a disulfide bond. This form of thiol crosslinking has been shown to occur and confirmed by mass spectrometry at the solution chemistry level, as well as in experiments documenting the potent antiproliferative activity of the bis-diazeniumdiolate Double JS-K in H1703 cells in vitro and in vivo. The modification is recognized by the anti-GSH antibody as if it were authentic S-glutathionylation, requiring mass spectrometry to distinguish between them. PMID:23106594

  4. Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl)) in rats.

    Science.gov (United States)

    Zhang, Hong; Liu, Quanhai; Fan, Tingting; Fang, Yu; Li, Ying; Wang, Guoping

    2012-03-01

    The metabolism and catabolism of a novel antineoplastic (ID code JS-38),Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl), were investigated in Wistar rats (3 female, 3 male). LC/UV, LC/MS, LC/MS/MS, NMR and acid hydrolysis methods showed that the metabolic process of JS-38 consists of a series of acetylation and glucoronation that form a metabolic product with a unique pharmacologic property of accelerating bone-marrow cell formation, and also showed a novel metabolic pathway of being acetylated and glucuronated in series.

  5. El imaginario de los adultos mayores sobre la vida después de la muerte

    Directory of Open Access Journals (Sweden)

    Felipe R. Vázquez Palacios

    2013-10-01

    Full Text Available El trabajo analiza el imaginario de los adultos mayores sobre la vida después de la muerte, en una muestra de creyentes mayores de 60 años, todos ellos creyentes católicos, metodistas, adventistas y pentecostales, que viven en la capital del estado de Veracruz, México. La información se llevó a cabo a través de entrevistas a profundidad y prácticas guiadas sobre el tema. La investigación muestra que el imaginario de la vida en el más allá, tiene que ver con acciones y prácticas, con contextos culturales, históricos, económicos, religiosos, costumbres que la sociedad y/o los individuos han acumulado en su vida cotidiana. La pregunta central que esta presente en todo el trabajo es: ¿Qué papel juegan estos imaginarios en la vida terrenal? ¿Cómo dotan de sentido la vida humana cómo la transforman?

  6. Optimization of Bacillus aerius strain JS-786 cell dry mass and its antifungal activity against Botrytis cinerea using response surface methodology

    Directory of Open Access Journals (Sweden)

    Shafi Jamil

    2017-01-01

    Full Text Available The optimization of fermentation conditions is necessary for field application of biological control agents. The present study was designed to optimize the fermentation conditions for the Bacillus aerius strain, JS-786 in terms of cell dry mass and its antifungal activity against Botrytis cinerea with response surface methodology. A strain of bacteria with strong antifungal activity was isolated from the phyllosphere of tomato plant and identified as B. aerius JS-786 based on the sequence homology of its 16S rRNA gene. After the success of preliminary antifungal activity tests, response surface methodology was used to optimize the fermentation conditions (medium pH, gelatin percentage, incubation period, rotatory speed and incubation temperature to maximize the cell dry mass and antifungal activity against B. cinerea. A 25 factorial central composite design was employed and multiple response optimization was used to determine the desirability of the operation. The results of regression analysis showed that at the individual level, all of the experimental parameters were significant for cell dry mass; significant results were obtained for antifungal activity pH, incubation period, rotatory speed and incubation temperature. The interactive effect of the incubation period, rotatory speed and incubation temperature was significant. Maximum cell dry mass (8.7 g/L and inhibition zone (30.4 mm were obtained at pH 6.4, gelatin 3.2%, incubation period 36.92 h, rotatory speed 163 rpm, and temperature 33.5°C. This study should help to formulate a more rational and cost-effective biological product both in terms of bacterial growth and antifungal activity.

  7. Absolute Magnetization Distribution on Back-arc Spreading Axis Hosting Hydrothermal Vents; Insight from Shinkai 6500 Magnetic Survey

    Science.gov (United States)

    Fujii, M.; Okino, K.; Honsho, C.; Mochizuki, N.; Szitkar, F.; Dyment, J.

    2013-12-01

    Near-bottom magnetic profiling using submersible, deep-tow, Remotely Operated Vehicle (ROV) and Autonomous Underwater Vehicle (AUV) make possible to conduct high-resolution surveys and depict detailed magnetic features reflecting, for instance, the presence of fresh lavas or hydrothermal alteration, or geomagnetic paleo-intensity variations. We conducted near-bottom three component magnetic measurements onboard submersible Shinkai 6500 in the Southern Mariana Trough, where five active hydrothermal vent fields (Snail, Yamanaka, Archean, Pica, and Urashima sites) have been found in both on- and off-axis areas of the active back-arc spreading center, to detect signals from hydrothermally altered rock and to distinguish old and new submarine lava flows. Fourteen dives were carried out at an altitude of 1-40 m during the R/V Yokosuka YK10-10 and YK10-11 cruises in 2010. We carefully corrected the effect of the induced and permanent magnetizations of the submersible by applying the correction method for the shipboard three-component magnetometer measurement modified for deep-sea measurement, and subtracted the IGRF values from the corrected data to obtain geomagnetic vector anomalies along the dive tracks. We then calculated the synthetic magnetic vector field produced by seafloor, assumed to be uniformly magnetized, using three dimensional forward modeling. Finally, values of the absolute magnetizations were estimated by using a linear transfer function in the Fourier domain from the observed and synthetic magnetic anomalies. The distribution of estimated absolute magnetization generally shows low values around the five hydrothermal vent sites. This result is consistent with the equivalent magnetization distribution obtained from previous AUV survey data. The areas of low magnetization are also consistent with hydrothermal deposits identified in video records. These results suggest that low magnetic signals are due to hydrothermal alteration zones where host rocks are

  8. Analgesia epidural para el alivio del dolor después del reemplazo de cadera o de rodilla

    Directory of Open Access Journals (Sweden)

    2014-07-01

    Conclusiones de los autores: La analgesia epidural puede ser útil para el alivio del dolor postoperatorio después de reemplazos importantes de articulaciones de los miembros inferiores. Sin embargo, los efectos beneficiosos pueden estar limitados al período postoperatorio temprano (cuatro a seis horas. Una infusión epidural de anestésico local o una mezcla de anestésico-narcótico local puede ser mejor que un narcótico epidural solo. La magnitud del alivio del dolor se debe sopesar contra la frecuencia de eventos adversos. Las pruebas actuales no son suficientes para establecer conclusiones sobre la frecuencia de complicaciones poco frecuentes de la analgesia epidural, la morbilidad o mortalidad postoperatorias, los resultados funcionales o la duración de la estancia hospitalaria.

  9. Confiabilidad y reproducibilidad de la escala de fototipos de Fitzpatrick antes y después de un ejercicio de estandarización clínica

    Directory of Open Access Journals (Sweden)

    Guillermo Sánchez

    2008-12-01

    Full Text Available Introducción. La escala de fototipos de Fitzpatrick permite conocer la sensibilidad de la piel frente a la luz ultravioleta; una estimación confiable del fototipo permite establecer el verdadero riesgo de cáncer de piel de acuerdo con esta característica. Objetivo. Establecer si existen diferencias en la concordancia intraobservador e interobservador de dos dermatólogos que evalúan el fototipo utilizando la escala de Fitzpatrick, antes y después de un proceso de estandarización clínica. Materiales y métodos. Se realizó un estudio analítico de concordancia intraobservador e interobservador. La escala de fototipos de Fitzpatrick se estandarizó mediante la metodología de grupos focales. Para conocer el acuerdo intra e interobservador se utilizó el estadístico kappa ponderado. El efecto de la estandarización se midió mediante un contraste de hipótesis de igualdad de coeficientes kappa utilizando el estadístico de Wald, a través de la metodología de mínimos cuadrados ponderados. Resultados. Se incluyeron 155 pacientes mayores de 15 años evaluados en cuatro oportunidades, por dos observadores independientes. En la fase de pre-estandarización, el kappa ponderado interobservador basal fue de 0,31 y de 0,40 a las seis semanas. El kappa intraobservador A fue de 0,47 y el intraobservador B fue de 0,51. Después del proceso de estandarización, se obtuvo un kappa ponderado interobservador basal de 0,77, y de 0,82 a las seis semanas. Los coeficientes kappa intraobservador A y B fueron 0,78 y 0,82, respectivamente. Se establecieron diferencias estadísticamente significativas entre los coeficientes antes y después de la estandarización (p=0,000 en todas las comparaciones. Conclusiones. La escala de fototipos de Fitzpatrick posterior a un ejercicio de estandarización arroja resultados confiables, reproducibles y estables en el tiempo.

  10. β(1,3 GLUCANASAS DE LOS ESPACIOS INTERCELULARES DE HOJAS DE TOMATE LYCOPERSICON ESCULENTUM CERACIFORME DESPUES DE INFECCIÓN CON PHYTOPHTHORA INFESTANS.

    Directory of Open Access Journals (Sweden)

    Humberto M. Zamora

    2009-06-01

    Full Text Available Análisis en líquido de lavado intercelular de Lycopersicon esculentum ceraciforme L1568 perteneciente al germoplasma nacional con resistencia en campo a P. infestans mostró la presencia de cuatro   β (1,3 glucanasas después de infección con el patógeno. Las plantas se inocularon con el patógeno para inducir aumento en la concentración de las proteínas PR. Después de 15 días de inoculadas, se extrajo el líquido de lavado intercelular de los foliolos de la planta utilizando agua destilada. Las proteínas extraídas se liofilizaron, se  resuspendieron en buffer, se purificaron utilizando cromatografía de intercambio iónico y electroforesis preparativa,  esto permitió la  caracterización parcial de una β (1,3  glucanasa básica con peso molecular  de 36,8 kDa y PI  9,2 y tres ácidas de  35.4, 30.1 y 7.2 kDa  con puntos isoeléctricos de 3.8; 3.6 y 5.0 respectivamente. Además se determinaron las propiedades cinéticas de cada enzima, KM, Vmax, Eo y K3 encontrando que la proteína básica no ha sido reportada en la literatura hasta ahora.

  11. MAGI: a Node.js web service for fast microRNA-Seq analysis in a GPU infrastructure.

    Science.gov (United States)

    Kim, Jihoon; Levy, Eric; Ferbrache, Alex; Stepanowsky, Petra; Farcas, Claudiu; Wang, Shuang; Brunner, Stefan; Bath, Tyler; Wu, Yuan; Ohno-Machado, Lucila

    2014-10-01

    MAGI is a web service for fast MicroRNA-Seq data analysis in a graphics processing unit (GPU) infrastructure. Using just a browser, users have access to results as web reports in just a few hours->600% end-to-end performance improvement over state of the art. MAGI's salient features are (i) transfer of large input files in native FASTA with Qualities (FASTQ) format through drag-and-drop operations, (ii) rapid prediction of microRNA target genes leveraging parallel computing with GPU devices, (iii) all-in-one analytics with novel feature extraction, statistical test for differential expression and diagnostic plot generation for quality control and (iv) interactive visualization and exploration of results in web reports that are readily available for publication. MAGI relies on the Node.js JavaScript framework, along with NVIDIA CUDA C, PHP: Hypertext Preprocessor (PHP), Perl and R. It is freely available at http://magi.ucsd.edu. © The Author 2014. Published by Oxford University Press.

  12. Después de Auschwitz: la persistencia de la barbarie

    Directory of Open Access Journals (Sweden)

    Foster, Ricardo

    2000-12-01

    Full Text Available The article broaches the specificity of Auschwitz tracking down the origins of antijudaism in the matricial structures of the first Christianity. The first aim is to bring into question the relationship between Western Christendom and Judaism. From then on, the plot of exclusion, first, then that of extermination, will be configured. Afterwards, the equivocal stand of Enlightment, the insurmountable conflict between Jewish particularity and assimilation will be discussed, reaching as far as Heidegger, his commitment to nazism and the final solution. In the last section, the concentrationary issue is tackled following some outlines elaborated by Giorgio Agamben, where the narrow relationship between sovereign power, state of exception, biopolitics and logic of the extermination are discussed highlighting their terrible continuity in the present age.

    En el artículo se intenta abordar la especificidad de Auschwitz persiguiendo los orígenes del antijudaísmo en las estructuras matriciales del primer cristianismo. El primer señalamiento a punta a una puesta en cuestión de la relación entre el Occidente cristiano y el judaísmo. A partir de allí se irá configurando la trama de la exclusión, primero, y del exterminio después. Luego se discute la equívoca posición de la ilustración, el conflicto insalvable entre la particularidad judía y la asimilación. Se llega hasta Heidegger, su compromiso con el nazismo y la solución final. En el último tramo se aborda la cuestión concentracionaria siguiendo algunos lineamientos elaborados por Giorgio Agamben donde se discuten las estrechas relaciones entre poder soberano, estado de excepción, biopolítica y lógica del exterminio destacando su terrible continuidad en la época actual.

  13. Evaluación del efecto de un bloqueador de canales de calcio sobre el aprendizaje después de la inducción a hipoxia neonatal en ratas

    Directory of Open Access Journals (Sweden)

    Nohora Ardila

    2000-07-01

    Full Text Available Se evaluó el aprendizaje de ratas sometidas a hipoxia perinatal y el efecto sobre el mismo de la nimodipina, edemas de las alteraciones producidas sobre algunos signos de maduración. Para la inducción a hipoxia se utiliza nitrógeno 100% en ratas de 24 horas de nacidas, el aprendizaje fue evaluado con un test de evitación pasivo y el medicamento fue inyectado por vía intraperitoneal (IP. En los 4 grupos experimentales, se observaron deficiencias de aprendizaje, especialmente en los grupos de hipoxia e hipoxia  con medicamento 5 minutes después de la exposici6n a nitrógeno. Estos resultados muestran que los efectos de la hipoxia sobre el aprendizaje no  fueron disminuidos por el medicamento, principal mente administrándolo 5 minutes después y que los dan os producidos par la hipoxia perinatal no pudieron ser evidenciados en el desarrollo físico de las ratas debido a que los signos de maduración no se vieron afectados.

  14. Micro-grid platform based on NODE.JS architecture, implemented in electrical network instrumentation

    Science.gov (United States)

    Duque, M.; Cando, E.; Aguinaga, A.; Llulluna, F.; Jara, N.; Moreno, T.

    2016-05-01

    In this document, I propose a theory about the impact of systems based on microgrids in non-industrialized countries that have the goal to improve energy exploitation through alternatives methods of a clean and renewable energy generation and the creation of the app to manage the behavior of the micro-grids based on the NodeJS, Django and IOJS technologies. The micro-grids allow the optimal way to manage energy flow by electric injection directly in electric network small urban's cells in a low cost and available way. In difference from conventional systems, micro-grids can communicate between them to carry energy to places that have higher demand in accurate moments. This system does not require energy storage, so, costs are lower than conventional systems like fuel cells, solar panels or else; even though micro-grids are independent systems, they are not isolated. The impact that this analysis will generate, is the improvement of the electrical network without having greater control than an intelligent network (SMART-GRID); this leads to move to a 20% increase in energy use in a specified network; that suggest there are others sources of energy generation; but for today's needs, we need to standardize methods and remain in place to support all future technologies and the best option are the Smart Grids and Micro-Grids.

  15. El mártir armenio: La construcción política de una figura ejemplar después del genocidio (1915-1918)

    OpenAIRE

    Antaramián Salas, Carlos

    2008-01-01

    La figura ejemplar del mártir ha tenido un papel fundamental en la política de memoria estructurada por las comunidades armenias después del genocidio (1915-1918); funge como imagen de honra nacional que ayuda al mantenimiento de la identidad armenia en espacios de asimilación (países anfitriones de la diáspora). En este artículo presento las transformaciones por las cuales ha transitado esta figura a partir de su puesta en escena cada 24 de abril, fecha de conmemoración del genocidio que se ...

  16. El mártir armenio: la construcción política de una figura ejemplar después del genocidio (1915-1918

    Directory of Open Access Journals (Sweden)

    Carlos Antaramián Salas

    2008-06-01

    Full Text Available La figura del mártir ha tenido un papel fundamental en la política de memoria estructurada por las comunidades armenias después del genocidio (1915-1918; funge como imagen de honra nacional que ayuda al mantenimiento de la identidad armenia en espacios de asimilación (países anfitriones de la diáspora. En este artículo presento las transformaciones por las cuales ha transitado esta figura a partir de su puesta en escena cada 24 de abril, fecha de conmemoración del genocidio.

  17. Prenatal Diagnosis and Molecular Analysis of a Large Novel Deletion (- -JS) Causing α0-Thalassemia.

    Science.gov (United States)

    Cao, Jinru; He, Shuzhen; Pu, Yudong; Liu, Jingjing; Liu, Fuping; Feng, Jun

    α-Thalassemia (α-thal) is a very common single gene hereditary disease caused by large deletions or point mutations of the α-globin gene cluster in tropical and subtropical regions of the world. Here, we report for the first time, a novel large α-thal deletion in a Chinese family from Jiangsu Province, People's Republic of China (PRC), which removes almost the entire α2 and α1 genes from the α-globin gene cluster. Thus, it was named the Jiangsu deletion (- - JS ) on the α-globin gene cluster causing α 0 -thal. Heterozygotes for this deletion showed an α-thal trait phenotype with reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (Hb) (MCH) levels. The sequencing results showed that a 2538 bp deletion (NG_000006.1: g.35801_38338) existed in this novel genotype on the basis of -α 4.2 (leftward), indicating a deletion of about 6.8 kb from the α-globin cluster. In addition, a 29 bp sequence was inserted into the deletion during the recombination events that led to this deletion. Through pedigree analysis, we knew that the proband inherited the novel allele from his mother.

  18. Vigilancia de la salud pública después de una erupción volcánica: lecciones aprendidas en Cerro Negro, Nicaragua, 1992

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    Malilay Josephine

    1997-01-01

    Full Text Available La erupción del volcán Cerro Negro cerca de León, Nicaragua, el 9 de abril de 1992 lanzó alrededor de 1,7 millones de toneladas de ceniza en una zona de 200 km². Se efectuó una evaluación inicial de los efectos en la salud de cerca de 300 000 residentes, con los datos normalmente obtenidos mediante el sistema nacional de vigilancia epidemiológica. Se determinó que el número de consultas a los establecimientos de atención de salud por diarrea e infecciones respiratorias agudas (IRA aumentó en las dos comunidades estudiadas, una dentro de la zona del desastre y otra en sus cercanías. En particular, las consultas por diarrea aguda fueron casi 6,0 veces más numerosas que antes de la erupción en ambas comunidades y las consultas por IRA, 3,6 veces más frecuentes en Malpaisillo (la comunidad cercana a la zona del desastre y 6,0 veces más frecuentes en Telica (la comunidad situada dentro de esa zona. Casi todas fueron consultas por enfermedad en lactantes y niños menores de 5 años. El aumento de la tasa de morbilidad por diarrea, que frecuentemente se produce después de las erupciones volcánicas, exige que se investiguen detalladamente el tipo y la calidad del abastecimiento de agua después de una acumulación cuantiosa de ceniza. Es preciso examinar con mayor detenimiento los problemas respiratorios asociados con la ceniza para determinar el espectro de esas enfermedades y el momento en que se presentan en lactantes y otros subgrupos especiales de la población. Los datos acopiados por medio de la vigilancia pasiva sobre las condiciones de salud antes y después de una erupción pueden emplearse para detectar la morbilidad relacionada con la erupción. Los sistemas que ya están establecidos, como el sistema nacional de vigilancia epidemiológica de Nicaragua, se pueden modificar o ampliar para mejorar su sensibilidad a nuevos casos y, por ende, su capacidad de ofrecer servicios de notificación apropiados a los organismos de

  19. La situación precaria de los derechos humanos en Estados Unidos en tiempos normales y después del 11 de septiembre de 2001

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    Stephen C. Thaman

    2009-12-01

    Full Text Available Esta ponencia critica el impacto del derecho penal y procesal penal de los Estados Unidos sobre los derechos humanos de ciudadanos estadounidenses en tiempos normales y los cambios que ocurrieron después de los atentados del 11 de septiembre 2001. Se concentra en las prácticas de racial profiling, pena de muerte, penas privativas de libertad draconianas en tiempos normales y el uso de detención ilimitada, tortura y escuchas secretas desde el 11-S.

  20. Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria.

    Directory of Open Access Journals (Sweden)

    Pedro Aguilar

    2012-03-01

    Full Text Available Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, observacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7% tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5% seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%. La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja.

  1. Comportamiento de las lesiones por quemaduras atendidas antes de las 72 horas y después de dicho período

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    Mario Lozada Chinea

    Full Text Available Introducción: las quemaduras representan uno de los accidentes más graves e incapacitantes, son una de las condiciones más devastadoras encontradas en la medicina. Objetivo: comparar el comportamiento de las lesiones por quemaduras en pacientes que recibieron atención especializada en las primeras 72 horas y después de dicho período, en la consulta externa de quemados del Hospital Universitario "General Calixto García". Métodos: se realizó un estudio longitudinal prospectivo de serie de casos. El universo estuvo constituido por los pacientes atendidos ambulatoriamente y con pronóstico de vida leve y menos grave. Las series se dividieron en pacientes que recibieron tratamiento tardíamente: grupo I y pacientes que recibieron atención antes de las primeras 72 horas: grupo II. Resultados: el 43,88 % de los pacientes del grupo 1 recibieron la atención al cuarto día y el 42,77 % presentaron signos de infección local. El 53,88 % de los pacientes del mismo grupo 1 fueron remitidos por sus médicos de familia y el 37,22 % presentó profundización en las lesiones. En ambos grupos predominó el tratamiento antibiótico local de las lesiones. Los pacientes del grupo 1 tuvieron un promedio de 16,59 días para la epitelización total de las lesiones, superior al grupo 2, lo que conllevó a un mayor número de sesiones de cura. Conclusiones: la atención especializada de las lesiones por quemaduras después de las primeras 72 horas, aumenta las probabilidades de infección y profundización como principales complicaciones, lo que contribuye a un retardo en el proceso de cicatrización y de rehabilitación.

  2. Como un cierre. Igualdad, honor y amistad entre contendientes directos, después de Malvinas

    Directory of Open Access Journals (Sweden)

    Rosana Guber

    2013-01-01

    Full Text Available Diez años después de concluido el conflicto anglo-argentino de 1982 conocido como la Guerra de Malvinas (Falklands en el mundo anglo-parlante comenzaron a salir a la luz pública los encuentros entre militares que habían sido contendientes directos. Estos encuentros, que fueron deseados, buscados y premeditados, y que se prolongaron luego en relaciones de amistad, incluyeron a tres pilotos argentinos del sistema de armas A-4B Skyhawk del Grupo 5 de Caza de la Fuerza Aérea, y personal aeronáutico o embarcado de Gran Bretaña. Este artículo busca comprender cómo significaron estos ex combatientes argentinos y británicos a sus encuentros, cómo se posicionaron recíprocamente y con respecto a sus roles en el combate y sus reflexiones en la postguerra. El artículo sostiene que en esos (reencuentros sus protagonistas actualizaron en la amistad una relación honorífica de igualdad que habían actuado en la contienda y que finalizó con la derrota argentina.

  3. Después del 11-S. Al-Qaeda vista por el análisis del discurso

    Directory of Open Access Journals (Sweden)

    Evelyn Norma Castro Méndez

    2010-01-01

    Full Text Available Después de los ataques del 11 de septiembre de 2001, se han publicado diversos estudios sobre el tema del terrorismo y la actuación de Al-Qaeda. Esta organización se ha caracterizado por emitir constantemente comunicados, cuyo estudio constituye una importante veta de investigación para las ciencias de la comunicación, el discurso político y las relaciones internacionales. En este contexto, el presente artículo examina algunos de los resultados del análisis semántico-pragmático aplicado al comunicado emitido por esta organización tras los atentados contra las Torres Gemelas y el Pentágono estadounidense, el cual fue uno de los más difundidos por la prensa nacional e internacional, comunicado que evidencia que la religión no es el eje argumentativo sustancial, sino la problemática política del Medio Oriente así como sus implicaciones en la relación Occidente-mundo islámico.

  4. El primer día de la niñez después de la guerra

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    María Paz Gómez-Gaviria

    2017-01-01

    Full Text Available El pasado mes de abril se celebró en Colombia el día de la niñez, una festividad que se realiza desde el año 2001, por medio de la Ley 724 del 27 de diciembre, con la cual el Congreso de la República de Colombia institucionalizó la Celebración del Día de la Niñez para el último sábado del mes de abril de cada año. Pero este día del niño del año 2017 tuvo una particularidad, porque es el primero que se celebra en el país después del cese al fuego que puso fin al conflicto entre el Estado y la guerrilla más antigua de América Latina, las Farc. La pregunta se abre para interpelar a todo un país, ¿qué celebramos en el pasado día de los niños y niñas?

  5. Un siglo aún por descubrir en la Historia de España: el siglo V después de Cristo

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    Francisco Javier Guzmán Armario

    2016-06-01

    Full Text Available El siglo V después de Cristo es, sin duda, el más desconocido de la Historia de España. Ello se debe a que, desde fines del siglo XIX, los historiadores han cultivado una imagen de esa centuria marcada por los vicios de la historiografía tradicional que incluso ha llegado a nuestro tiempo. En la actualidad, es necesario recurrir a nuevos planteamientos metodológicos (en este artículo el autor propone cuatro argumentos al respecto y a nuevas perspectivas en Arqueología si se quiere corregir esa deficiencia en un siglo tan importante para la Historia de España.

  6. Fast/Major and Slow/Minor pairings in J.S. Bach's Well Tempered Clavier Books 1 and 2

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    Katelyn Horn

    2012-07-01

    Full Text Available Some studies have found that subjects give higher preference ratings and clearer emotional descriptions to pieces with the tempo/mode pairs fast/major and slow/minor. If these findings are true, one might expect to find a predominance of fast/major and slow/minor pairings in musical literature. This study looks for just such a trend in the canonical work of J.S. Bach’s Well Tempered Clavier. Books 1 and 2 together contain 24 Major Preludes, 24 Minor Preludes, 24 Major Fugues and 24 Minor Fugues. We use four different measurements of fast/slow tempo based both on elements within the musical notation as well as the interpretive markings of four different music editors: 1. Attacks Per Beat (APB – measures the number of subdivisions of each piece 2. Attacks Per Minute (APM – is the APB of a piece multiplied by the editor’s metronome marking 3. Time Signature Distribution and 4. Editor’s Tempo Distribution. We find a significant amount of fast/major and slow/minor pairings in Book 1 but not in Book 2.

  7. An integrated program to train local health care providers to meet post-disaster mental health needs Programa integrado para entrenar a proveedores de servicios sanitarios locales a satisfacer las necesidades de salud mental después de un desastre

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    Stan Kutcher

    2005-11-01

    Full Text Available This paper describes a post-disaster mental health training program developed by the International Section of the Department of Psychiatry at Dalhousie University (Halifax, Canada and delivered in Grenada after Hurricane Ivan struck the country in September 2004. This train-the-trainer program used an integrated community health model to help local health care providers develop the necessary skills for the identification and evidenced-based treatment of mental disorders occurring after a natural disaster. The approach also provided for ongoing, sustainable mental health care delivered in the community setting, as advocated by the World Health Organization and the Pan American Health Organization. This approach is in contrast to the largely ineffective and costly vertical whole-population psychosocial counseling activities that have often been used in the Caribbean following natural disasters.En el presente trabajo se describe un programa de entrenamiento para la atención de la salud mental después de desastres, desarrollado por la Sección Internacional del Departamento de Psiquiatría de la Universidad de Dalhousie (Halifax, Canadá y llevado a cabo en la isla de Granada después de que el huracán Iván azotó ese país en septiembre de 2004. Este programa de entrenamiento para entrenadores utilizó un modelo integrado de salud comunitaria para ayudar a los proveedores de los servicios sanitarios locales a desarrollar las habilidades necesarias para identificar los trastornos mentales frecuentes después de un desastre natural y aplicar tratamientos basados en pruebas científicas. Este programa también favorece el enfoque actual de atención sostenible de salud mental en la comunidad, promovido por la Organización Mundial de la Salud y la Organización Panamericana de la Salud. Además, se contrapone a las actividades verticales de consejería psicosocial dirigidas a toda la población, en su mayoría ineficaces y costosas, que se han

  8. Cohort Profile: The JS High School study (JSHS): a cohort study of Korean adolescents.

    Science.gov (United States)

    Choi, Dong Phil; Lee, Joo Young; Kim, Hyeon Chang

    2017-04-01

    Major aetiologies of atherosclerotic cardiovascular diseases begin in childhood and atherosclerotic vascular abnormalities can be observed among children and adolescents. Adolescent cohort studies have important advantages because they can observe earlier changes in vascular structure and function. The purpose of the JS High School study (JSHS) is to identify biomarkers predicting or indicating early structural and functional vascular change in adolescents. The JSHS is a prospective cohort study of a Korean adolescent population. The target population of the JSHS was first-graders (aged 14 to17 years) at a high school of South Korea. Enrolment and baseline examinations were conducted in years 2007, 2010, 2011 and 2012. Among the total eligible population of 1115 students, 1071 (96.1%) participated in the study and completed all baseline examinations. Informed consent forms were obtained from each participant and his/her parent or guardian. Baseline examinations include: questionnaires on demographics, health behaviours, medical history, and depression symptoms; fasting blood analysis; anthropometric measurement; body impedance analysis; blood pressure measurement; radial artery tonometry; bone densitometry; pulmonary function tests; and carotid ultrasonography. Participants enrolled from 2007 through 2012 were re-examined after 30 months of follow-up, and those who enrolled in 2012 were re-examined after 24 months of follow-up. The corresponding author may be contacted for potential collaboration and data access. © The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  9. Infecciones pulmonares en pacientes con VIH 20 años después de la terapia antirretroviral combinada. ¿Qué ha cambiado?

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    Johanna Osorio

    Full Text Available Introducción: Antes del año 1996, la infección por el virus de la inmunodeficiencia humana (VIH era considerada una condición fatal; sin embargo, con la introducción de la terapia antirretroviral combinada, se transformó en una enfermedad crónica con gran incremento en su expectativa de vida. A pesar de esta terapia, existen una serie de complicaciones a las que los individuos con VIH están expuestos. El pulmón es el órgano más comúnmente afectado. Las infecciones oportunistas como la neumonía por Pneumocystis jirovecii , el compromiso pulmonar asociado a histoplasmosis, tuberculosis y micobacterias no tuberculosas, entre otras, aún son condiciones que amenazan a esta población. Objetivo: Esta revisión pretende abordar los cambios en el diagnóstico, pronóstico y epidemiología de los pacientes con VIH e infecciones pulmonares, luego de la introducción de la terapia antirretroviral combinada. Metodología: Se revisaron las bases de datos electrónicas MEDLINE (pubmed, EMBASE, SciELOy LILACS. Se incluyeron revisiones sistemáticas, ensayos clínicos aleatorizados, estudios controlados, series de tiempo, « antes y después » , estudios observacionales desde el año 1995 hastadiciembre de 2014, así como datos epidemiológicos de la OMS. Conclusiones: Después de casi 20 años de su introducción, la terapia antirretroviral combinadaha modificado la historia natural de la infección por VIH, con disminución en la frecuencia depresentación y mortalidad relacionada con la mayoría de los patógenos que comprometen eltracto respiratorio

  10. Cambios cualitativos en la familia afectada por acné conglobata después de una intervención médica integral. Hospital Vladimir Ilich Lenin. 2009

    Directory of Open Access Journals (Sweden)

    Raquel Rojas-Bruzón

    2012-01-01

    Full Text Available Se presentaron los cambios cualicuantitativos en los integrantes de una familia afectada por el acné conglobata después de hacerles un diagnóstico del conocimiento acerca de su enfermedad y otras variables respecto a su tratamiento. Se les realizó un proceso de orientación sobre su padecimiento, además de un tratamiento intensivo farmacológico, quirúrgico y de asesoramiento genético que provocó cambios importantes en la evolución de estos pacientes.

  11. Estado oxidante-antioxidante en pacientes obesas antes y después de una dieta y ejercicio : cambios estructurales de la insulina expuesta a sangre de pacientes obesas

    OpenAIRE

    Gutiérrez López, Liliana

    2012-01-01

    Programa de Doctorado en Alto Rendimiento Deportivo Introducción: Varios estudios han mostrado que la dieta y el ejercicio son importantes en el tratamiento de la obesidad. De hecho, el estado de estrés oxidativo del paciente obeso mejora después del ejercicio de moderada intensidad; lo cual pone de manifiesto la importancia de ambos para disminuir los efectos adversos del estrés oxidativo durante el tratamiento de la obesidad. El objetivo de este trabajo fue determinar si el tratamiento c...

  12. Respuesta de anticuerpos inducidos por la vacuna antimeningocócica cubana VA-MENGOC-BC® frente a la cepa de Neisseria meningitidis B:4:P1.19,15 en adolescentes después de 12 años de inmunizados

    Directory of Open Access Journals (Sweden)

    María A. Camaraza

    2006-12-01

    Full Text Available Se estudió la respuesta de anticuerpos inducida por la vacuna antimeningocócica cubana VA-MENGOC-BC® contra la cepa de Neisseria meningitidis B:4:P1.19,15 mediante el Ensayo Bactericida del Suero (EBS y ELISA de tipo indirecto, para medir anticuerpos contra vesículas de membrana externa (VME de N. meningitidis B a 184 adolescentes de un politécnico de Ciego de Ávila que fueron inmunizados en campañas masivas 12 años antes. Se realizaron extracciones de sangre antes de aplicar la primera dosis (T0, 4 semanas después de ésta (T1 y 4 semanas después de la segunda dosis (T2. Transcurridos 12 años de esta vacunación el 42% de los adolescentes presentó títulos bactericidas ≥ 1:4 frente a la cepa homóloga (B:4:P1.19,15 y el 98% mostró anticuerpos detectables contra las VME. En el EBS; el porcentaje de seroconversión T1/T0 fue del 57% y T2/T0 del 60%. Mediante ELISA la seroconversión fue del 59% y 54%, respectivamente, por lo que se demostró que la aplicación de una sola dosis después de 12 años indujo una respuesta inmune importante que puede sugerir una respuesta anamnésica.

  13. Secondhand Smoke Exposure and Depressive Symptoms among Korean Adolescents: JS High School Study.

    Directory of Open Access Journals (Sweden)

    Na Hyun Kim

    Full Text Available Increasing evidence suggests that secondhand smoke exposure (SHSE may affect not only physical health, but also mental health. Therefore, we evaluated the association between SHSE and depressive symptoms among Korean adolescents.The JS High School Study enrolled 1071 high school freshmen from a rural community of South Korea. The current analysis was limited to 989 adolescents (495 male and 494 female adolescents, after excluding 48 ever-smokers, 3 students with physician-diagnosed depression, and 31 students who did not complete the depression questionnaire. SHSE was assessed using a self-reported questionnaire and was classified into three groups: none, occasional exposure, and regular exposure. Depressive symptoms were assessed according to the Beck Depression Inventory (BDI score, ranging from 0 to 63, and the presence of depressive symptoms was defined as a BDI score ≥10.Overall, adolescents with SHSE were more likely to have depressive symptoms than those without SHSE (p = 0.042.In a sex-specific analysis treating the BDI score as a continuous variable, regular SHSE was independently associated with higher BDI scores in male adolescents (β = 2.25, p = 0.026, but not in female adolescents (β = 1.11, p = 0.253. Compared to no SHSE, the odds ratio for having depressive symptoms among male adolescents with regular SHSE was 2.17 (95% confidence interval, 1.11 to 4.25 after adjusting for age, body mass index, and study year, and 3.65 (95% confidence interval, 1.52 to 8.73 after adjusting for age, body mass index, study year, exercise, and household income.Regular exposure to secondhand smoke was associated with having depressive symptoms among Korean male adolescents.

  14. Secondhand Smoke Exposure and Depressive Symptoms among Korean Adolescents: JS High School Study.

    Science.gov (United States)

    Kim, Na Hyun; Park, Ji Hye; Choi, Dong Phil; Lee, Joo Young; Kim, Hyeon Chang

    2016-01-01

    Increasing evidence suggests that secondhand smoke exposure (SHSE) may affect not only physical health, but also mental health. Therefore, we evaluated the association between SHSE and depressive symptoms among Korean adolescents. The JS High School Study enrolled 1071 high school freshmen from a rural community of South Korea. The current analysis was limited to 989 adolescents (495 male and 494 female adolescents), after excluding 48 ever-smokers, 3 students with physician-diagnosed depression, and 31 students who did not complete the depression questionnaire. SHSE was assessed using a self-reported questionnaire and was classified into three groups: none, occasional exposure, and regular exposure. Depressive symptoms were assessed according to the Beck Depression Inventory (BDI) score, ranging from 0 to 63, and the presence of depressive symptoms was defined as a BDI score ≥10. Overall, adolescents with SHSE were more likely to have depressive symptoms than those without SHSE (p = 0.042).In a sex-specific analysis treating the BDI score as a continuous variable, regular SHSE was independently associated with higher BDI scores in male adolescents (β = 2.25, p = 0.026), but not in female adolescents (β = 1.11, p = 0.253). Compared to no SHSE, the odds ratio for having depressive symptoms among male adolescents with regular SHSE was 2.17 (95% confidence interval, 1.11 to 4.25) after adjusting for age, body mass index, and study year, and 3.65 (95% confidence interval, 1.52 to 8.73) after adjusting for age, body mass index, study year, exercise, and household income. Regular exposure to secondhand smoke was associated with having depressive symptoms among Korean male adolescents.

  15. Exposition index calculation from different points in a gamma sterilization plant radiation room

    International Nuclear Information System (INIS)

    Carrasco, A.H.

    1983-01-01

    Radiation fields produced by a JS-6500 rectangular irradiator source were evaluated. Knowledge of the values of these fields is necessary in irradiation and health physics processes. Techniques for evaluating the dose rates from puntual, linear and plane sources were applied and computer programs for the three sources designed. Fricke, cupric-ferrous and red acrilic dosimetric systems were used, to verify the eight points located along the interior walls of the irradiation room, around the source with 936, 987 Ci of Co-60 (1st-March 1980). When considering the distance between the source and each point of interest the calculated exposition indexes obtained were practically the same for the three source types and were up to 35% greater than the experimental values; in contrast when absorption and buildup of the source were taken in to account, the experimental values were higher than the calculated ones by up to 16%, this in estimating the produced exposition index for a rectangular source at least there two parameters should be included. (author)

  16. Uso de la crema Vimang® en la cicatrización alveolar después de la extracción dentaria en un paciente con diabetes mellitus

    OpenAIRE

    Alemán Miranda, Otto; Corona Carpio, Marcia Hortensia; Domínguez Rodríguez, Yamila

    2017-01-01

    Se presenta el caso clínico de un anciano de 75 años de edad, con antecedentes de hipertensión arterial y diabetes mellitus, quien acudió a consulta estomatológica para que le extrajeran el segundo molar inferior izquierdo por presentar gran destrucción debido a caries dental. Después de concluir el proceder se le aplicó la crema Vimang® directamente en el alveolo para acelerar los procesos de cicatrización y evitar cualquier complicación inmediata o mediata; luego se indicó 4 veces al día de...

  17. Los efectos jurídicos del fallo del Excelentísimo Tribunal Constitucional sobre la llamada “píldora del día después”

    OpenAIRE

    Ángela Vivanco M.

    2008-01-01

    El tema de la llamada “píldora del día después” o “píldora del día siguiente” se inició en Chile con una serie de acciones ante los tribunales ordinarios con resultados muy contradictorios, tras lo cual el fallo del Tribunal Constitucional de abril de 2008 resultó una importante definición acerca del estatuto del embrión humano, la protección de la vida y el principio precautorio aplicado a ella, aunque no pudo extenderse a todas las materias relacionadas con la PDD por ser la competencia del...

  18. Modificaciones en la composición corporal después de realizar una prueba de ultrarresistencia de 1.700 km en bicicleta de montaña

    Directory of Open Access Journals (Sweden)

    Vicente Clemente Suárez

    2010-01-01

    Full Text Available El estudio de los cambios en la composición corporal en pruebas de resistencia se ha limitado en la mayoría de los casos al estudio de las pérdidas de peso corporal. El presente estudio pretende analizar los cambios producidos en la composición corporal (agua, proteínas, minerales, grasa, y músculo producidos después de realizar una prueba de 1.700 Km en bicicleta de montaña cruzando África de este a oeste. Se analizaron 5 sujetos (73,3±10,2 kg, 170±0,1 cm, 51,2±6,9 años antes y después de realizar una prueba de ultrarresistencia en bicicleta de montaña de 1.700 km durante 17 días (100-110 km por etapa. Se analizaron los siguientes parámetros: Masa Agua Intracelular, Masa Agua Extracelular, Proteínas, Masa Mineral, Masa Grasa Corporal, Agua Corporal Total, Masa Músculo Esquelético, Masa Libre de Grasa, Peso y Área Grasa Visceral mediante bioimpedancia eléctrica (BIA con el analizador INBODY 720. Los resultados muestran una disminución no significativa de los parámetros de peso corporal y masa grasa, una disminución significativa en el área de grasa visceral (p>0,05. El resto de parámetros se mantuvieron en valores cercanos a la toma inicial. En conclusión este tipo de pruebas de ultrarresistencia únicamente afecta a los parámetros de grasa visceral, manteniendo el resto de variables de composición corporal sin cambios significativos.

  19. Modificaciones en la composición corporal después de realizar una prueba de ultrarresistencia de 1.700 km en bicicleta de montaña

    OpenAIRE

    Clemente Suárez, Vicente J.; González-Ravé, José María

    2010-01-01

    El estudio de los cambios en la composición corporal en pruebas de resistencia se ha limitado en la mayoría de los casos al estudio de las pérdidas de peso corporal. El presente estudio pretende analizar los cambios producidos en la composición corporal (agua, proteínas, minerales, grasa, y músculo) producidos después de realizar una prueba de 1.700 Km en bicicleta de montaña cruzando África de este a oeste. Se analizaron 5 sujetos (73,3±10,2 kg, 170±0,1 cm, 51,2±6,9 a...

  20. Foliar application of pyraclostrobin fungicide enhances the growth, rhizobial-nodule formation and nitrogenase activity in soybean (var. JS-335).

    Science.gov (United States)

    Joshi, Juhie; Sharma, Sonika; Guruprasad, K N

    2014-09-01

    A field study was conducted to investigate the impact of the fungicide pyraclostrobin (F500 - Headline®; a.i. 20%) on the activity of nitrogenase in soybean (var. JS-335). Pyraclostrobin (F500) was applied on the leaves of soybean plants at 10 and 20 days after emergence (DAE) of seedlings at concentrations ranging from 0.05% to 1%. Leghemoglobin (Lb) content and nitrogenase activity in root nodules were analyzed at 45(th)day after emergence of seedlings indicated a remarkable increase in Lb content and enhanced activity of nitrogenase in the root nodules of pyraclostrobin treated plants. The fungicide also enhanced the number of nodules along with weight of nodules, root biomass and growth of shoot and leaves. Enhanced nitrogen fixation in the root nodules by pyraclostrobin improves the growth of the plant in soybean before flowering and pod formation which ultimately resulted in yield and yield attributes. These results suggest that pyraclostrobin (F500) can be successfully employed as a foliar spray under field conditions to enhance the growth, nitrogen assimilation and hence yield of soybean. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. La relación euro-dólar: seis años después que el euro presentase su mínimo nivel

    Directory of Open Access Journals (Sweden)

    John Jairo García Rendón

    2007-10-01

    Full Text Available Este artículo muestra la relación del tipo de cambio euro-dólar desde que el euro empezó a circular. Específicamente, después de considerar algunos elementos teóricos que determinan el tipo de cambio, explica los principales hechos que llevaron a que el euro a partir de octubre de 2000 revertiera su tendencia decreciente frente al dólar y qué aspectos están influyendo en la actualidad sobre su desempeño, llegando a la conclusión que no es posible establecer un modelo que pondere las variables de forma racional y significativa, haciendo que el comportamiento del tipo de cambio no pueda ser explicado en su totalidad por la teoría económica existente.

  2. biojs-io-biom, a BioJS component for handling data in Biological Observation Matrix (BIOM format [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Markus J. Ankenbrand

    2017-01-01

    Full Text Available The Biological Observation Matrix (BIOM format is widely used to store data from high-throughput studies. It aims at increasing interoperability of bioinformatic tools that process this data. However, due to multiple versions and implementation details, working with this format can be tricky. Currently, libraries in Python, R and Perl are available, whilst such for JavaScript are lacking. Here, we present a BioJS component for parsing BIOM data in all format versions. It supports import, modification, and export via a unified interface. This module aims to facilitate the development of web applications that use BIOM data. Finally, we demonstrate its usefulness by two applications that already use this component. Availability: https://github.com/molbiodiv/biojs-io-biom, https://dx.doi.org/10.5281/zenodo.218277

  3. Mar adentro (2004. Una visión diferente seis años después del Óscar

    Directory of Open Access Journals (Sweden)

    Antonio-León AGUADO DÍAZ

    2016-11-01

    Full Text Available En este trabajo se exponen diversos aspectos sobre la premiada película “Mar adentro”, de Alejandro Amenábar, analizados seis años después de la obtención del Óscar. Es de sobra conocido que el largometraje narra la historia real de un tetrapléjico, Ramón Sampedro, recalcando las vicisitudes del protagonista hasta conseguir poner fin a su vida. Se hace un análisis de los personajes de la cinta, se recogen las críticas tanto las populares como las cinematográficas y se analiza la visión que se ofrece de la discapacidad. Respetando la opción personal del protagonista, y conscientes de que el tema principal no es la discapacidad sino la eutanasia, se presenta una visión crítica del enfoque ofrecido de la tetraplejia y, en última instancia, de la lesión medular, por considerar que indirectamente resalta aspectos negativos en detrimento de un enfoque positivo de la vivencia con dicha discapacidad. En definitiva, por mostrar una imagen contraria a lo que se viene defendiendo desde este equipo, a saber, que la discapacidad, incluida la lesión medular, es compatible con ser feliz.

  4. Mortalidad por enfermedad diarreica en menores, antes y después de la introducción de la vacuna contra el rotavirus Analysis of the mortality due to diarrhea in younger children, before and after the introduction of rotavirus vaccine

    Directory of Open Access Journals (Sweden)

    Marcelino Esparza-Aguilar

    2009-08-01

    Full Text Available OBJETIVO: Analizar la mortalidad por diarrea en menores de cinco años en México, antes y después de la vacunación contra el rotavirus. MATERIAL Y MÉTODOS: Se compararon defunciones y mortalidad por diarrea mediante diferencias porcentuales anuales por grupo etario, antes (2000-2005 y después (2006-2007 de la vacunación. RESULTADOS: Entre 2000 y 2007 la mortalidad por diarrea disminuyó 42%. En los estados con vacunación, la mortalidad se redujo 15.8 y 27.7% en menores de uno y de uno a cuatro años, respectivamente, en el periodo de 2006 a 2007. DISCUSIÓN: La reducción observada en la mortalidad por diarrea en menores de cinco años después de 2005 puede atribuirse en parte a la vacunación contra el rotavirus.OBJECTIVE: To analyze the mortality due to acute diarrhea in children younger than five years old, before and after the introduction of rotavirus vaccine in Mexico. MATERIAL AND METHODS: Number of deaths and mortality rates due to acute diarrhea were compared by children's age and states' vaccine status using annual percentage differences before (2000-2005 and after (2006-2007 the introduction of the HRV. RESULTS: From 2000-2007, deaths due to acute diarrhea in children under five years of age dropped 42%. In those states that received the HRV early in 2006, diarrhea mortality decreased between 2006-2007 15.8% in children younger than one year old and 22.7% in children 1-4 years old. DISCUSSION: The observed reduction in mortality due to acute diarrhea in children under five years of age after 2005 can be, in part, attributed to the HRV.

  5. Fertilización nitrogenada después de la poda del cafeto robusta en Cambisoles

    Directory of Open Access Journals (Sweden)

    Alberto Pérez Díaz

    2011-08-01

    Full Text Available El objetivo de este trabajo fue evaluar la influencia de la fertilización mineral nitrogenada, después de la poda del cafeto robusta, sobre la productividad del cultivo y algunos indicadores químicos (pH, materia orgánica y microbiológicos (respiración biológica y nitrificación de dos Cambisoles en Tercer Frente, Santiago de Cuba y La Alcarraza, Holguín, durante los años 2003-2007. Se estudió la respuesta a dosis crecientes de nitrógeno (0 hasta 400 kg ha-1, en presencia de un fondo fijo de P (50 kg ha-1 y K (160 kg ha-1, en un diseño experimental de bloques al azar, con cuatro réplicas. Para productividades entre 0,50 y 0,84 Mg ha-1 de café, son suficientes 75 kg ha-1 de N. Aplicaciones de 100 kg ha-1 de N permitieron productividades de 1,22 a 1,25 Mg ha-1de café. Con dosis de 153 kg ha-1 de N, se logran producciones de 1,80 Mg ha-1 de café, mientras que para productividades superiores a 2 Mg ha-1 se necesita aplicar 200 kg ha-1 en ambos suelos. Se encontró un incremento importante en las productividades del cafeto por cada quilogramo de N aplicado, que osciló entre 2,13 y 7,80. Las dosis propuestas por sitio no afectaron la actividad microbiana y la materia orgánica de los suelos. Se encontró disminución del pH del suelo respecto a su estado inicial.

  6. Aislamiento de genes diferencialmente expresados en amastigotes de Leishmania (Viannia panamensis

    Directory of Open Access Journals (Sweden)

    Róbinson Ramírez

    2001-04-01

    Full Text Available

    En Colombia cada año se diagnostican 6.500 casos nuevos de
    leishmaniasis cutánea y Leishmania (Viannia panamensis es la responsable del 95% de los casos. Durante su ciclo de vida, el parásito reside en el insecto vector como promastigote y se diferencia a amastigote después de ser inoculado en el hospedero mamífero. La transformación de promastigote a amastigote implica cambios morfológicos y bioquímicos que tienen lugar en el fagolisosoma del macrófago, y se caracterizan, entre otros, por la expresión de enzimas con actividad óptima a pH ácido además del cambio de los glicoconjugados de membrana. La supervivencia del parásito está asociada con su capacidad para inhibir funciones efectoras en el macrófago infectado permitiéndole al amastigote
    su replicación; sin embargo, poco se conoce acerca de los productos génicos expresados diferencialmente en este estadio por lo que nos propusimos con este trabajo aislar genes diferencialmente expresados en amastigotes de Leishmania (Viannia panamensis.

     

     

  7. Design Experience on a Multi-Mecacurie Radiation Facility; Etudes et experiences concernant un emetteur de rayonnements de plusieurs megacuries; Opytnoe proektirovani e ustanovki, obladayushchej sverkhmoshchnym izlucheniem; Estudios sobre el proyecto de un dispositivo de irradiacion de varios megacuries

    Energy Technology Data Exchange (ETDEWEB)

    Brunton, D C; Donovan, J; Voyvodic, L [Curtiss-Wright Corporation, Princeton, NJ (United States); Armour Research Foundation, 10 W. 35th Street, Chicago 10, IL (United States)

    1960-07-15

    securite et les organes de commande de l'installation sont egalement etudies. Enfin, le memoire decrit la preparation du produit qui emet les rayonnements, y compris sa mesure, sa mise en capsule et la verification pour prevenir les fuites. (author) [Spanish] Los autores describen los trabajos de investigacion y perfeccionamiento realizados con miras a la construccion de fuentes adecuadas para el ''Irradiador de elevada intensidad para alimentos''. Los problemas que estudian son los comunes a todos los irradiadores transportables de gran tamano. La primera fase de los trabajos consistio en adquirir conocimientos mas exactos sobre las fuentes de placa y de los efectos que las variaciones de los parametros constructivos ejercen sobre el rendimiento de esas instalaciones. En primer lugar, se llevo a cabo un estudio teorico, experimental y mediante maquinas de calcular del rendimiento de los irradiadores de placa unica. Los parametros considerados han sido el tamano y la actividad especifica de la fuente, su espesor y revestimiento, la densidad del blanco y factores geometricos tales como la altura, longitud y anchura de la fuente y del blanco, asi como las dimensiones del volumen de aire que separa la fuente del blanco. Se ha estudiado el rendimiento en funcion de la capacidad del irradiador, del tiempo de exposicion, de la uniformidad de la dosis, de la eficacia de la instalacion y de los costes totales. Se han propuesto formulas simplificadas para calcular el rendimiento de los irradiadores; la validez de esas formulas se ha comprobado experimentalmente. Se ha establecido un codigo tridimensional que permite aplicar el metodo denominado de ''Monte Carlo'' al calculo del rendimiento de los irradiadores; los resultados obtenidos estan en armonia con los datos determinados por via experimental. El programa de estudio se ha extendido a los dispositivos de varias placas y de varios pasos, y abarca por consiguiente tanto las fuentes de tres dimensiones como los irradiadores de

  8. Estudio topoaberrométrico en Lasik después de queratotomía radial Topoaberrometric study in Lasik after radial keratotomy

    Directory of Open Access Journals (Sweden)

    Yamila Díaz Parra

    2007-12-01

    Full Text Available La cirugía refractiva personalizada consiste en adecuar el tratamiento de cada paciente según las características de la córnea y corregir defectos que afectan la calidad de la visión; por ejemplo, las aberraciones ópticas. Se seleccionaron 21 ojos de 13 pacientes con miopía residual después de queratotomía radial. Se realizó agudeza visual sin corrección y con ella, queratometría, refracción dinámica, refracción ciclopléjica; topografía corneal, taquimetría, tonometría, biomicroscopia, estudio de la lágrima y fondoscopia. A todos se les aplicó el software de análisis de frente de onda corneal y se realizó Lasik (Queratomileusis in situ con láser y queratectomía refractiva optimizada. La agudeza visual sin corrección varió de 0,17 a 0,75. El equivalente esférico promedio se modificó de -4,81 D a -0,67 D. Las aberraciones de alto orden (HORMS prequirúrgicas y posquirúrgicas variaron de 0,970 um hasta 1,130 um. La agudeza visual sin corrección fue superior a 0,8 en todos los casos después de la cirugía de Lasik. Disminuyó el equivalente esférico y el componente cilíndrico en todos los ojos. Las aberraciones totales disminuyeron también en todos los casos.Customized refractive surgery means adapting treatment to the patient according to the corneal characteristics and correcting defects that affect the quality of vision, for example, optical aberrations. Twenty one eyes from 13 patients with residual myopia after undergoing radial keratotomy were selected. Visual acuity without correction and also, keratometry, dynamic refraction, cycloplegic refraction, corneal topography, tachymetry, tonometry, biomicroscopy, study of the tear and funduscopy were performed. All the eyes were applied the sofware for analysis of corneal wavefront and Lasik (Queratomileusis in situ with laser and optimized refractive keratectomy were performed. Visual acuity without correction changed from 0.17 to 0.75. Average sphere equivalent

  9. A novel marine bacterium Isoptericola sp. JS-C42 with the ability to saccharifying the plant biomasses for the aid in cellulosic ethanol production

    Directory of Open Access Journals (Sweden)

    Velayudhan Satheeja Santhi

    2014-06-01

    Full Text Available The ever growing demands for food products such as starch and sugar produces; there is a need to find the sources for saccharification for cellulosic bioethanol production. This study provides the first evidence of the lignocellulolytic and saccharifying ability of a marine bacterium namely Isoptericola sp. JS-C42, a Gram positive actinobacterium with the cocci cells embedded on mycelia isolated from the Arabian Sea, India. It exhibited highest filter paper unit effect, endoglucanase, exoglucanase, cellobiohydrolase, β-glucosidase, xylanase and ligninase effect. The hydrolytic potential of the enzymes displayed the efficient saccharification capability of steam pretreated biomass. It was also found to degrade the paddy, sorghum, Acacia mangium and Ficus religiosa into simple reducing sugars by its efficient lignocellulose enzyme complex with limited consumption of sugars. Production of ethanol was also achieved with the Saccharomyces cerevisiae. Overall, it offers a great potential for the cellulosic ethanol production in an economically reliable and eco-friendly point-of-care.

  10. A novel marine bacterium Isoptericola sp. JS-C42 with the ability to saccharifying the plant biomasses for the aid in cellulosic ethanol production.

    Science.gov (United States)

    Santhi, Velayudhan Satheeja; Gupta, Ashutosh; Saranya, Somasundaram; Jebakumar, Solomon Robinson David

    2014-06-01

    The ever growing demands for food products such as starch and sugar produces; there is a need to find the sources for saccharification for cellulosic bioethanol production. This study provides the first evidence of the lignocellulolytic and saccharifying ability of a marine bacterium namely Isoptericola sp. JS-C42, a Gram positive actinobacterium with the cocci cells embedded on mycelia isolated from the Arabian Sea, India. It exhibited highest filter paper unit effect, endoglucanase, exoglucanase, cellobiohydrolase, β-glucosidase, xylanase and ligninase effect. The hydrolytic potential of the enzymes displayed the efficient saccharification capability of steam pretreated biomass. It was also found to degrade the paddy, sorghum, Acacia mangium and Ficus religiosa into simple reducing sugars by its efficient lignocellulose enzyme complex with limited consumption of sugars. Production of ethanol was also achieved with the Saccharomyces cerevisiae . Overall, it offers a great potential for the cellulosic ethanol production in an economically reliable and eco-friendly point-of-care.

  11. Análisis de la capacidad de salto antes, durante y después de la competición en jugadores internacionales junior de baloncesto. (Analysis of jumping capacity before, during and after competition in international junior basketball players.

    Directory of Open Access Journals (Sweden)

    Jaime San Román Quintana

    2010-10-01

    Full Text Available Resumen El objetivo de este estudio fue valorar la disminución de la altura de salto en el test CMJ antes, durante y después de la competición en nueve jóvenes jugadores internacionales de baloncesto. Del mismo modo, se analizó la relación entre los minutos que cada jugador permanecía en cancha y la disminución de la capacidad de salto. Para ello, se evaluó la altura de salto mediante el CMJ en 8 momentos diferentes (antes y después del calentamiento, durante el descanso, inmediatamente después del partido y en los minutos 1’, 3’, 5’ y 7’ tras la finalización del encuentro utilizando una plataforma de contacto. Para estimar la presencia de diferencias significativas entre los momentos se utilizó el análisis de la varianza (ANOVA de una cola. Los resultados demuestran que la capacidad de salto empeoró progresivamente durante la competición (F = 89.29, p = 0, descendiendo durante el descanso de 52.7 cm a 50.2 cm (p abstract The main aim of this study was to assess the decrease in jump height in CMJ test before, during and after competition in international youth basketball. Equally, we examined the relationship between minutes played and the decline in jump capacity during the course of the match. To do this, we evaluated the jump height in CMJ by eight different times (before and after warm up, at rest, immediately after the game and within minutes 1', 3', 5 'and 7' after completion of the competition using a contact platform. To estimate the presence of significant differences between the times we used a one – way analysis of variance (ANOVA. The results showed, that the jumping capacity decreased during competition (F = 89.29, p = 0, decrease during the rest of 52.7 cm to 50.2 cm (p

  12. Concentraciones séricas de interleucina 2 y su receptor soluble, antes y después de una cirugía Serum concentrations of interleukin 2 and its soluble receptor, before and after surgery

    Directory of Open Access Journals (Sweden)

    Maczy González Rincón

    2006-12-01

    Full Text Available Con el objetivo de determinar las concentraciones séricas de interleucina 2 (IL-2 y su receptor soluble (RsIL-2 antes y después de una cirugía y su relación en cada período de estudio, se determinó, mediante inmunoensayo enzimático, los niveles de IL-2 y RsIL-2 antes y 24 horas después de la cirugía en 40 pacientes sometidos a cirugía menor y cirugía mayor. En cirugía menor se obtuvieron niveles promedio para IL-2 de 0,938 y 0,139 U/mL, para RsIL-2 de 364,8 y 497 pg/mL; mientras que en cirugía mayor los valores fueron: para IL-2 de 2,03 y 0,114 U/mL y RsIL-2 de 319,7 y 600 pg/mL, en cada período respectivamente. La disminución observada de los niveles de IL-2 y el incremento del RsIL-2 en cirugía mayor y menor podría sugerir una alteración de la respuesta inmunitaria celular, generada no sólo por el estrés quirúrgico, sino posiblemente por el efecto reconocido de los anestésicos en la depresión de la función óptima del sistema inmunitario

  13. Niveles del factor de crecimiento derivado de plaquetas en el plasma rico en plaquetas antes y despues de antiagregantes plaquetarios

    Directory of Open Access Journals (Sweden)

    Maczy González

    2013-09-01

    Full Text Available El PDGF es uno de los mitógenos más potentes para el tejido conectivo, su secreción parece ser particularmente importante cuando la fuente es el Plasma Rico en Plaquetas (PRP, de allí el rol protagónico de este último en la regeneración tisular. Se determinó mediante ELISA los niveles de PDGFBB en el PRP, Plasma Pobre en Plaquetas (PPP y Exudado de 32 sujetos sanos antes y 24 horas después de ingerir AAS (Aspirina y Clopidogrel. Los niveles basales de PDGFBB ueron de 10, 6 ± 1, 9 ng/ml (PPP, 12, 12 ± 2, 5 ng/ml (PRP y 10, 84 ± 1, 68 ng/ml (Exudado. Mientras que después del tratamiento con AAS las concentraciones de PDGFBB estuvieron en 8, 96 ± 1, 4 ng/ml (PPP, 11, 36 ± 1, 48ng/ml (PRP, 11, 11 ± 1, 14ng/ml (Exudado y para el Clopidogrel fueron de 8, 53 ± 0, 59 ng/ml (PPP, 9, 65 ± 1, 17 ng/ml (PRP y 8, 51 ± 0, 75 ng/ml (Exudado. Se notó que luego de la administración de AAS y Clopidogrel los valores de PDGFBB disminuyeron de manera estadísticamente significativa, en especial para el grupo del Clopidogrel. El AAS pareció afectar en menor grado las concentraciones de PDGFBB, lo cual puede ser atribuible al mecanismo de acción farmacológica diferencial existente entre la AAS y Clopidogrel. No se encontró correlación entre el recuento plaquetario y los niveles basales de PDGFBB del PRP. PDGF levels in platelet-rich plasma before and after anti platelets drugs Abstract PDGF is one of the most potent mitogen for connective tissue, its secretion appears to be particularly important when the source is Platelet Rich Plasma (PRP, hence the latter leading role in tissue regeneration. ELISA PDGFBB levels in PRP, Platelet Poor Plasma (PPP and exudates, were determined in 32 healthy subjects before and 24 hours after ingestion of Aspirin (ASA and Clopidogrel (CLO. PDGFBB baseline levels were 10.6 ± 1.9 ng / ml (PPP, 12.12 ± 2.5 ng / ml (PRP and 10.84 ± 1.68 ng / ml (exudate. After treatment with ASA concentrations were PDGFBB in 8

  14. Queratitis lamelar difusa después del Lasik Diffuse lamellar keratitis after LASIK

    Directory of Open Access Journals (Sweden)

    Lorelei Ortega Díaz

    2010-12-01

    Full Text Available OBJETIVO: Describir el comportamiento de la queratitis lamelar difusa como complicación después de emplear la técnica quirúrgica queratomileusis in situ con láser. MÉTODOS: Se realizó un estudio descriptivo, de corte transversal en el Servicio de Cirugía Refractiva Corneal del Instituto Cubano de Oftalmología "Ramón Pando Ferrer" en el último trimestre del año 2008. La muestra quedó conformada por 16 ojos a los que se les realizó la queratomileusis in situ con láser como técnica quirúrgica para corregir ametropía y que presentaron complicaciones con esta cirugía. Se analizaron variables como la agudeza visual sin corrección; los ojos con esta complicación fueron analizados según la clasificación de Linebarger. RESULTADOS: La frecuencia de queratitis lamelar difusa fue de 3,0 por cada 100. La agudeza visual no corregida se comportó entre 0,8 y 1,0 en 12 ojos de 16 afectados, el estadio 1 se presentó en 12 ojos. CONCLUSIONES: La queratitis lamelar difusa es una complicación poco frecuente, los casos que la padecieron alcanzaron una buena agudeza visual final sin corrección. Predominó la forma leve de este cuadro.OBJECTIVE: To describe the situation of Diffuse lamellar keratitis as a complication after in situ keratomileusis with laser. METHODS: A descriptive cross-sectional study was carried out in the Refractive Corneal Service of "Ramón Pando Ferrer" Cuban Institute of Ophthalmology during the last quarter of 2008. The sample embraced 16 eyes that underwent in situ keratomileusis plus laser as the refractive procedure to correct ametropy and presented with some complications. Visual acuity without correction was one the analyzed variables and the eyes with this type of complication were classified according to Linebarger´s classification. RESULTS: The diffuse lamellar keratitis frequency was 3.0 per one hundred cases, the visual acuity without correction was 0.8 to 1.0 in 12 out of 16 eyes whereas stage 1 was

  15. jfewr ©2017 - jfewr Publications

    African Journals Online (AJOL)

    OMERJI

    stomachs while 65.00% samples had different food items in their stomachs. Out of the 65.00% stomachs ... http://www.ajol.info/index.php/jrfwe jfewr ©2017 - jfewr ..... organisms at different trophic levels (food chain) could be the possible ...

  16. Los Juegos Olímpicos de Barcelona, 25 años después (2

    Directory of Open Access Journals (Sweden)

    Francesc Solanellas

    2017-06-01

    Full Text Available En el artículo inicial de la serie se realizó una primera aproximación al legado y al impacto de los Juegos Olímpicos de Barcelona realizados hace 25 años; en este segundo trabajo de revisión tratamos de profundizar en el impacto que estos tuvieron para la ciudad y el país. En el anterior, se llevó a cabo un análisis económico, social y deportivo de lo que se ha considerado el modelo Barcelona; ahora intentamos profundizar y sobre todo realizar análisis comparados con otros países para evaluar si ese impacto fue tan relevante como creíamos. Este análisis económico se basa en el estudio de variables tales como el número de turistas (incremento entre 1992 y 2015, el número de visitantes internacionales durante este periodo, el número de hoteles o el número de pasajeros recibidos. En el análisis deportivo se hace un exhaustivo análisis comparado de los resultados olímpicos obtenidos en diferentes sedes valorando la participación, el número y tipo de medallas, y la clasificación conseguida según el caso. Desde el punto de vista social, se profundiza en el deporte escolar valorando algunas de las variables de prácticas deportivas en las escuelas. De acuerdo con los resultados del anterior artículo, y después de un análisis en profundidad y comparado, se puede afirmar que el incremento del número de visitantes en los últimos 25 años en Barcelona es superior al de la mayoría de ciudades de referencia. A nivel deportivo también se aprecia que el número de medallas fue, proporcionalmente, mayor en España que en otros países organizadores

  17. Characterization and disposal of ion exchange resins used in nuclear installations

    International Nuclear Information System (INIS)

    Flores E, R.M.; Ortiz O, H.B.; Olguin G, M.T.; Emeterio H, M.; Garcia M, H.

    2006-01-01

    To dispose of an appropriate way the used ion exchange resins so much in the pool water purification systems of the TRIGA Mark III reactor like in the JS6500 gamma irradiator, of the National Institute of Nuclear Research, were carried out a series of analytic nuclear techniques and complementary conventional to those recommended by the ASTM, with the object of to control and to manage 14 lots of worn out resins appropriately. For its were identified the radioactive isotopes, the resins type, the grade of chemical pollution and the physicochemical degradation of the same ones. The lots of resins that didn't contain radioactive isotopes its were regenerated in an usual way, as long as those that if they controlled them they selected options for its final disposition. The first selected option was the extraction method of ion radioactive isotopes, concentrating the elution product by evaporation. As second option it was carried out the resins stabilization damaged by micro-encapsulation by forged to ambient temperature, using an organic polymer. Previous to the immobilization the resins were pretreated by vacuum drying, pulverization and thermal drying, however before carrying out this last, it was carried out a thermal gravimetric analysis to determine the drying conditions of the resins avoiding its chemical decomposition. (Author)

  18. Characterization and disposal of ion exchange resins used in nuclear installations; Caracterizacion y disposicion de resinas de intercambio ionico utilizadas en instalaciones nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Flores E, R.M.; Ortiz O, H.B.; Olguin G, M.T.; Emeterio H, M.; Garcia M, H. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    To dispose of an appropriate way the used ion exchange resins so much in the pool water purification systems of the TRIGA Mark III reactor like in the JS6500 gamma irradiator, of the National Institute of Nuclear Research, were carried out a series of analytic nuclear techniques and complementary conventional to those recommended by the ASTM, with the object of to control and to manage 14 lots of worn out resins appropriately. For its were identified the radioactive isotopes, the resins type, the grade of chemical pollution and the physicochemical degradation of the same ones. The lots of resins that didn't contain radioactive isotopes its were regenerated in an usual way, as long as those that if they controlled them they selected options for its final disposition. The first selected option was the extraction method of ion radioactive isotopes, concentrating the elution product by evaporation. As second option it was carried out the resins stabilization damaged by micro-encapsulation by forged to ambient temperature, using an organic polymer. Previous to the immobilization the resins were pretreated by vacuum drying, pulverization and thermal drying, however before carrying out this last, it was carried out a thermal gravimetric analysis to determine the drying conditions of the resins avoiding its chemical decomposition. (Author)

  19. Progress in food irradiation: South Africa

    International Nuclear Information System (INIS)

    Linde, H.J. van der

    1978-01-01

    The most significant development to date is the commissioning of a pilot plant for the treatment of subtropical fruits at Tzaneen (N. Transvaal) in January 1977. The purpose of this facility is to generate commercial quantities of treated produce for process and product evaluation. The irradiator consists of a six-metre-deep pool filled with water. The product is lowered in two large, watertight containers which surround the plaque source. To provide for dose homogeneity, the containers are rotated at half the exposure time. With the present loading of cobalt-60, the treatment time for one batch of approximately 350 kg of fruit is approximately one hour. The pilot plant has been successfully used this year to treat approximately 6.5 t of mangoes in the commercial sea-shipment trial, as well as several small consignments of avocados and papayas sent to local markets for evaluation. The existing facilities are the same as described in the previous report. The commercial sterilization plant (AECL JS6500) has been up-graded to 400 kCi of cobalt-60. The research loop in this plant has been utilized to treat 10.5 t of potatoes which were supplied to local supermarkets for trial sale purposes. (orig.) [de

  20. Variaciones hematológicas y de presión sanguínea en perros después de una picadura de abejas

    Directory of Open Access Journals (Sweden)

    Jorge Muñoz G.

    2013-03-01

    Full Text Available Objetivo. El objetivo de este estudio fue determinar los cambios hematológicos y de presión arterial en perros después de una picadura cutánea de abejas. Material y métodos. Se utilizaron 10 perros adultos, a los cuales se les inoculó veneno de abeja mediante una picadura cutánea controlada. De cada animal se extrajo una muestra de sangre previa y los 15 y 300 minutos post inoculación. Se registró la presión arterial sistólica (PAS, diastólica (PAD, media (PAM y de pulso (PP desde 15 minutos previos hasta 45 minutos posteriores a la inoculación. Resultados. El recuento de eritrocitos, el hematocrito y la concentración de hemoglobina se redujeron a los 15 minutos post-inoculación (p0.05. Conclusiones. La picadura cutánea de abejas produce un descenso transitorio del recuento de eritrocitos, hematocrito y concentración de hemoglobina, junto con una disminución en el recuento de reticulocitos y del recuento relativo de eosinófilos, sin alterar mayormente la presión sanguínea.

  1. Fatores de risco cardiovascular em pacientes pediátricos após um ano de transplante renal Factores de riesgo cardiovascular en pacientes pediátricos después de un año de trasplante renal Cardiovascular risk factors in pediatric patients after one year of renal transplant

    Directory of Open Access Journals (Sweden)

    Líndia Kalliana da Costa Araújo Alves Carvalho

    2010-01-01

    Full Text Available OBJETIVO: Identificar a frequência de diabetes mellitus e a presença de fatores de risco cardiovascular em pacientes pediátricos após um ano de transplante renal. MÉTODOS: Estudo retrospectivo, de cunho documental e exploratório, realizado de janeiro de 2000 a janeiro de 2006, abrangendo 111 prontuários de pacientes pediátricos (0 a 18 anos incompletos submetidos a transplante renal no Hospital do Rim e Hipertensão e no Hospital São Paulo da Universidade Federal de São Paulo. RESULTADOS: Foram analisados 111 pacientes, 50,5% utilizavam anti-hipertensivos antes do transplante renal. Um ano após este número caiu para 28%. No pré-transplante 13,5% pacientes apresentaram sobrepeso e após um ano não houve alteração importante (12,6%. O número de pacientes obesos aumentou 50% após um ano de transplante renal. Aproximadamente 1% das crianças desenvolveram diabetes mellitus pós-tranplante renal. CONCLUSÃO: A presença de excesso de peso (sobrepeso e obesidade, hipertensão arterial e diabetes mellitus são freqüentes em pacientes pediátricos pós-tranplante renal.OBJETIVO: Identificar la frecuencia de diabetes mellitus y la presencia de factores de riesgo cardiovascular en pacientes pediátricos después de un año de trasplante renal. MÉTODOS: Estudio retrospectivo, de orden documental y exploratorio, realizado de enero de 2000 a enero de 2006, abarcando 111 fichas de pacientes pediátricos (0 a 18 años incompletos sometidos a trasplante renal en el Hospital del Riñón e Hipertensión y en el Hospital Sao Paulo de la Universidad Federal de Sao Paulo. RESULTADOS: Fueron analizados 111 pacientes, 50,5% utilizaban anti-hipertensores antes del trasplante renal. Un año después este número cayó para 28%. En el pre-trasplante, 13,5% pacientes presentaron sobrepeso y después de un año no hubo alteración importante (12,6%. El número de pacientes obesos aumentó 50% después de un año de trasplante renal. Aproximadamente 1

  2. Queratitis lamelar difusa después de un corte incompleto Diffuse lamellar keratitis after incomplete corneal flap cut

    Directory of Open Access Journals (Sweden)

    Yanaisa Riverón Ruiz

    2012-12-01

    Full Text Available La queratitis lamelar difusa es una inflamación estéril de la interfase lamelar que suele presentarse 24 horas después de la realización de la queratomileusis in situ asistida con láser y potencialmente puede comprometer la agudeza visual final. Se presenta un paciente de 25 años de edad con antecedentes de cirugía refractiva corneal mediante queratomileusis in situ con láser en el ojo derecho, que tuvo como complicación durante el acto quirúrgico un corte incompleto. En el posoperatorio inmediato se le diagnosticó una queratitis lamelar difusa. Se aplicó tratamiento local y se obtuvo la recuperación visual total del paciente con estabilidad del defecto refractivo. Esto permite posteriormente realizarle la corrección mediante cirugía refractiva de superficie.The diffuse lamellar keratitis is a sterile swelling of the lamellar interface which arises generally 24 hours after laser in situ keratomileusis and might affect the final visual acuity. A 25 years- old patient with history of corneal refractive surgery by laser in situ keratomileusis on his right eye was reported. He suffered from an incomplete corneal flap cut as complication during the surgical procedure, and a diffuse lamellar keratitis was detected at the immediate postsurgical visit. Total visual recovery and the refractive defect stability were attained through local treatment. This allows further correcting the defect by means of a surface refractive surgery in the future.

  3. Los medios y la privatización del ENTEL. El tratamiento noticioso del servicio telefónico argentino antes y después de su transferencia (agosto de 1990 – enero de 1991). Un estudio exploratorio

    OpenAIRE

    Aruguete, Natalia

    2009-01-01

    Aruguete, N. (2015). Los medios y la privatización del ENTEL. El tratamiento noticioso del servicio telefónico argentino antes y después de su transferencia (agosto de 1990 – enero de 1991). Un estudio exploratorio (Tesis de Doctorado). Universidad Nacional de Quilmes, Bernal, Argentina. El objetivo de esta Tesis es analizar el tratamiento y la percepción mediáticos de la última etapa de gestión estatal del servicio telefónico argentino (agosto – octubre de 1990) vis a vis la primera de ad...

  4. Efecto agudo del entrenamiento muscular excéntrico sobre la estabilidad del miembro inferior durante el aterrizaje después de caida desde diferentes alturas en jóvenes futbolistas de élite

    OpenAIRE

    Mateo Cortés, Jesús

    2013-01-01

    El objetivo principal de la presente investigación fue analizar el efecto agudo de una sesión de entrenamiento de fuerza con sobrecarga excéntrica sobre la estabilidad del miembro inferior tras aterrizaje después de caída desde altura de 30 cm y 50 cm. La muestra estuvo constituida por un total de dieciocho jugadores de fútbol (edad = 17 ± 1.2 años; altura = 178 ± 2,34 cm; peso = 71 ± 4.56 kg; IMC = 19.12 ± 2.45) pertenecientes a la cantera de un equipo profesional de fútbol de la liga españo...

  5. Afectividad inducida e impacto en la creatividad, crecimiento personal después del cambio y ajuste percibido al narrar una experiencia emocional intensa

    Directory of Open Access Journals (Sweden)

    Silvia da Costa

    2015-05-01

    Full Text Available Se examinan en un estudio experimental los efectos de la inducción de afectividad positiva en la creatividad y la importancia de las emociones como variables mediadoras. Se indujo alta y baja afectividad positiva pidiendo a las personas participantes que redactaran tres poemas haikus sobre dos estímulos de connotación positiva, alta (N = 28 y baja (N = 28. Las personas escribieron sobre su experiencia de enamoramiento más intenso y contestaron una escala sobre las emociones sentidas al redactar el texto, una medida de crecimiento personal y una tercera referida a la obtención de metas adaptativas después del episodio. En la condición de alta afectividad positiva se informó de más emociones positivas y menos negativas al narrar la experiencia, un mayor crecimiento personal y un mayor ajuste. Jueces independientes evaluaron como más originales el último poema y la narración de la experiencia en la condición de alta afectividad positiva. Un análisis mediacional mostró que las emociones positivas explicaban la influencia de la manipulación sobre el crecimiento personal y el ajuste percibido.

  6. Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study.

    Science.gov (United States)

    Park, Ji Hye; Mun, Seyeon; Choi, Dong Phil; Lee, Joo Young; Kim, Hyeon Chang

    2017-12-11

    Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL cholesterol and pulmonary function in healthy adolescents. This cross-sectional study was based on data collected for the JS High School study. The analysis included 644 adolescents (318 male and 326 female) aged 15-16 years old and free from asthma or chronic obstructive pulmonary disease. Fasting blood samples were collected for hematologic and biochemical assessment. Forced vital capacity volume (FVC) and forced expiratory volume in the 1 s (FEV1) were measured using dry-rolling-seal spirometry. The associations between HDL cholesterol and pulmonary function were analyzed using multiple linear regression models. Among male adolescents, an increase of 1.0 mg/dL in HDL cholesterol was associated with 10 mL decrease in FVC (p = 0.013) and FEV1 (p = 0.013) after adjusting for age, height, weight, alcohol drinking, smoking, physical activity, systolic blood pressure, total cholesterol, triglyceride, and monthly household income. Percent predicted values of FVC (p = 0.036) and FEV1 (p = 0.017) were also inversely associated with HDL cholesterol. However, among female adolescents, HDL cholesterol level was not significantly associated with absolute or percent predictive value of FVC and FEV1. Higher HDL cholesterol level may be associated with decreased pulmonary function among healthy male adolescents. The sex differences observed in the association between HDL cholesterol and pulmonary function need further investigation.

  7. Cambios en la vegetacion de un campo abandonado despues de un cultivo de trigo Vegetation changes in a field abandoned after a wheat crop

    Directory of Open Access Journals (Sweden)

    Silvia Irene Boccanelli

    1999-02-01

    Full Text Available La vegetación prístina de los campos altos del sur de Santa Fe (Argentina son distintos tipos de flechillares caracterizados por la abundancia de varias especies del género Stipa. Cuando un campo agrícola se abandona suele revertir a las comunidades prístinas. El objeto de este trabajo es analizar los diez primeros años de la sucesión secundaria de un campo sometido a agricultura durante largo tiempo que se abandonó después de un cultivo de trigo (Triticum aestivum. En el primer año aparece trigo acompañado de malezas anuales (Chenopodium album y Portulaca oleracea; después del primer año una parcela fue colonizada por Baccharis salicifolia y las otras por Carduus acanthoides, Cerastium glomeratum, Ammi majus, etc. Los últimos años constituyen una etapa en la que disminuye la diversidad y se establece una fuerte dominancia de Baccharis salicifolia o Carduus acanthoides. El Sorgo de Alepo (Sorghum halepense aparece en las etapas tempranas y perdura durante todo el período con valores altos de abundancia. Aún, prácticamente no han aparecido especies de los flechillares, por lo tanto se concluye que no ha transcurrido suficiente tiempo para que se regenere el flechillar, o porque sus especies no se encuentran en los bancos de semillas o en las proximidades.The natural vegetation of well drained fields of Southern Santa Fe (Argentina are a different kind of communities characterized by the abundance of several species of Stipa. When agricultural lands are abandoned, they are often recolonized by the original vegetation. The object of this paper is to analize the first ten years of secondary succession on a field under a long time of agriculture abandoned after a wheat crop. On the first year, wheat with annual weeds (Chenopodium album and Portulaca oleracea appeared. After the first year, one plot was colonized by Baccharis salicifolia and the others by Carduus acanthoides, Cerastium glomeratum, Ammi majus, etc. The last years

  8. Las comunidades meiobentónicas en playas arenosas expuestas de la costa gallega (NO España), seis meses después del vertido de fuel del Prestige: importancia de los hidrocarburos aromáticos policíclicos (HAPs)

    OpenAIRE

    Veiga, Puri; Besteiro, Celia; Rubal, Marcos

    2010-01-01

    Este trabajo tiene como objetivo evaluar el efecto de los hidrocarburos aromáticos policíclicos (HAPs) en playas arenosas gallegas, seis meses después del vertido de fuel producido por el Prestige, utilizando el meiobentos a nivel de los grandes grupos zoológicos. Para llevar a cabo esta evaluación la comunidad meiobentónica, variables ambientales y el contenido en HAPs del sedimento fueron estudiados en seis playas intermareales afectadas y comparados con tres localidades de referencia. Tamb...

  9. Cambios en las expectativas y las actitudes de los trabajadores de la hostelería después de la ley de medidas sanitarias frente al tabaquismo Changes in hospitality workers' expectations and attitudes after the implementation of the Spanish smoking law

    Directory of Open Access Journals (Sweden)

    Jose M. Martínez-Sánchez

    2010-06-01

    Full Text Available Objetivo: Evaluar los cambios en las expectativas y las actitudes sobre la Ley 28/2005 de medidas sanitarias frente al tabaquismo de los trabajadores de la hostelería tras 2 años de su entrada en vigor. Métodos: Estudio longitudinal de una cohorte de trabajadores del sector de la hostelería de cinco comunidades autónomas (n=431 antes de la entrada en vigor de la ley y 24 meses después. Se comparararon el conocimiento de la ley, las expectativas de cumplimiento y los conocimientos sobre los efectos adversos del tabaquismo pasivo antes y después de la ley. Resultados: De los 431 trabajadores participantes iniciales se obtuvo respuesta de 219 a los 2 años (tasa de seguimiento del 50,8%. El 79,0% de los trabajadores conocía el proyecto de ley antes de su entrada en vigor, frente al 94,1% que afirmó conocerla después (pObjective: To assess changes in hospitality workers' expectations and attitudes towards the Spanish smoking law before and 2 years after the smoking ban. Methods: We performed a longitudinal study of a cohort (n=431 of hospitality workers in five regions in Spain before the law came into effect and 24 months later. Expectations and attitudes towards the ban and knowledge about the effect of second-hand smoke on health were compared before and after the ban. Results: We recruited 431 hospitality workers in the baseline survey and 219 were followed-up 24 months later (overall follow-up rate of 50.8%. The percentage of hospitality workers who knew the law was 79.0% before it was passed and was 94.1% 24 months later (p<0.05. We observed an increase in support to the smoke-free ban in all public places, including bars and restaurants (54.1% to 65.8%; p<0.05. The percentages of support for the current ban, perception of compliance with the ban by employees and customers, and knowledge of the effect of second-hand smoke on health also increased. Conclusions: Knowledge and support to the Spanish smoking law among hospitality workers

  10. Análisis de la imagen china en la prensa española a través de las noticias antes, durante y después de los Juegos Olímpicos de Beijing 2008

    OpenAIRE

    Wang, Xiyue

    2014-01-01

    El objetivo general de este trabajo es discutir la imagen de China en los diarios españoles a través del análisis de las noticias sobre China de los dos diarios representantes,La Vanguardia y ABC,especialmente en el período en que se celebran los Juegos Olímpicos de Beijing 2008. La imagen de China en la prensa española es "comunismo","el desarrollo de la economía","falta de derechos humanos","falta la libertad","una técnica avanzada" y "un país con mucha historia y cultura". Y después de la ...

  11. Immediate effect on vertical jumping ability after the completion of trampoline jumping Efecto inmediato sobre la capacidad de salto vertical después de la realización de saltos en cama elástica

    Directory of Open Access Journals (Sweden)

    M. Fernández del Olmo

    2010-09-01

    salto vertical con contramovimiento (CMJ, realizaron una serie de saltos verticales continuos sobre una cama elástica durante 60 segundos, valorándose la capacidad de salto en plataforma de contactos antes y después de ésta actividad. Se registró la actividad electromiográfica (EMG de cinco músculos de la pierna derecha (glúteo, bíceps femoral, vasto externo, gemelo interno y sóleo los saltos de CMJ. La altura de salto disminuyó significativamente (p< 0.01 después de la realización de los saltos en la cama elástica, recuperándose en un breve periodo de tiempo. No se observaron diferencias en la EMG para la raíz media cuadrática (RMS ni la amplitud en ninguno de los músculos, ni en la fase de impulso, ni en los 50 ms previos al inicio del salto. En el patrón neuromuscular, a pesar de la gran variabilidad existente inter e intraindividuos, se identificó un retraso significativo (p<0.05 en la activación del bíceps femoral inmediatamente después de la cama elástica. Teniendo en cuenta estos resultados, parece probable que la menor altura del salto vertical alcanzada después de la cama elástica sea más atribuible a una modificación en las características temporales y secuencia de activación de los músculos que a una disminución en la activación de los mismos.
    PALABRAS CLAVE: Salto vertical, Patrón neuromuscular, Superficie elástica, Electromiografía .

  12. Los Migrantes Mexicanos: Acercamiento a un Análisis del Fenómeno Después de los Atentados Terroristas del 11 de Septiembre de 2001 en Estados Unidos

    Directory of Open Access Journals (Sweden)

    Oscar Hugo Pedraza Rendón

    2008-12-01

    Full Text Available En el presente documento se analizan los rasgos que asumió el flujo migratorio de mexicanos hacia los Estados Unidos después de los atentados terroristas del 11 de septiembre de 2001. Con este ataque el tema migratorio en la agenda binacional ha pasado a segundo plano, es más la unión americana decide reforzar sus fronteras invirtiendo capital y recursos humanos para custodiarla. De esta forma, el cruce de la frontera se hace más costoso y peligroso al grado de cobrar gran cantidad de vidas humanas. Por otro lado, dichas medidas antimigratorias han convertido al migrante en delincuente, situación que no favorece en lo absoluto a la salud mental de nuestros connacionales. Dado lo anterior es pertinente establecer mecanismos que aseguren el bienestar físico y mental de los migrantes tanto en Estados Unidos como en México.

  13. La judicialización del caso de la píldora del día después en Chile: las tensiones sobre el rol de la mujer y la cuestión técnica

    OpenAIRE

    Miranda Pérez , Fabiola

    2012-01-01

    Este articulo trata sobre el debate en torno a la introducción de la píldora del día después en Chile. Esta discusión se posicionó en la agenda pública a finales de los años '90, planteándose como problemática durante una década. Los objetivos de esta investigación son, en primer lugar, mostrar cómo esta temática que concierne a los derechos sexuales y reproductivos de las mujeres fue tratada por el poder judicial, principalmente de la parte del órgano encargado de controlar la constitucional...

  14. Encefalopatía de Wernicke y polineuropatía asociada a déficit de complejo B después de una cirugía bariátrica

    Directory of Open Access Journals (Sweden)

    Tomas Carvajal

    2012-12-01

    Full Text Available La cirugía bariátrica es un tratamiento que garantiza una pérdida de peso sustancial y duradera, y beneficios tangibles respecto a condiciones médicas asociadas a la obesidad. El aumento del número de cirugías bariátricas ha llevado también a un aumento de las complicaciones relacionadas con ella, incluyendo la encefalopatía de Wernicke y la polineuropatía por deficiencia de vitaminas del complejo B. En este artículo se reporta un caso de encefalopatía de Wernicke siete semanas después de la cirugía, enfatizando en la importancia de reconocer el espectro de la sintomatología para hacer un diagnóstico temprano, que permita intervenir en la fase reversible de esta enfermedad potencialmente letal.   doi: http://dx.doi.org/10.7705/biomedica.v32i4.765

  15. Estudio de parámetros metabólicos en sujetos jóvenes sometidos a ejercicio sub-máximo después de la administración de mate de coca, en la exposición aguda de altura

    OpenAIRE

    Mujica, Elydia; Ronceros, Gerardo; Torres, Javier; Pinto, Rogelio; Ponciano, Walter; Bravo, Yelitz; López, Milena; Gallardo, Duber; Salinas, César; Calderón, Segundo; Villareal, Carmen; Yampufé, Manuel

    2013-01-01

    Objetivos: Determinar los parámetros metabólicos glucosa, colesterol, triglicéridos, HDL, en sujetos jóvenes sometidos a ejercicio sub-máximo después de la administración de mate de coca, en exposición aguda de altura. Diseño: Estudio experimental. Institución: Instituto Nacional de Biología Andina. Instituto de Investigaciones Clínicas y Sección Fisiología de la Facultad de Medicina, UNMSM. Participantes: Estudiantes universitarios varones nativos del nivel del mar. Intervenciones: Se estudi...

  16. Efecto del número de aplicaciones de cloprostenol sobre la regresión de cuerpos lúteos, el retorno al celo y la ovulación, después de un tratamiento superovulatorio en donantes de embriones bovinos

    OpenAIRE

    Cabra, C.; Garzón, J. V.; Tribulo, A.; Mapletoft, R.; Jiménez, C.; Bo, G.

    2011-01-01

    El objetivo del presente trabajo fue evaluar la respuesta de la aplicación doble o triple de prostaglandina sobre la regresión de CL, ovulación y retorno al celo después de un tratamiento superovulatorio en vacas donantes de embriones. Para este experimento se tomaron 44 vacas asignadas al azar a dos grupos de tratamiento. Al primero (n = 23; CLO 0 & 7) se le aplicó una dosis de 500 μg de cloprostenol los días 0 (denominado día de la colecta) y 7; al segundo grupo (n = 21; ...

  17. Reintervenciones por complicaciones después de realizada colecistectomía laparoscópica Reinterventions in complications of the laparoscopic cholecystectomy

    Directory of Open Access Journals (Sweden)

    Rosalba Roque González

    2011-09-01

    Full Text Available Durante estos años varios centros con experiencia en colecistectomía laparoscópica han publicado sus complicaciones y tratamiento a estas. El objetivo de este estudio es describir la experiencia en 23 pacientes reintervenidos por complicaciones posoperatorias de la colecistectomía laparoscópica realizadas en el Centro Nacional de Cirugía de Mínimo Acceso, según el reporte de los resultados obtenidos. Se realizó un estudio descriptivo, retrospectivo y longitudinal, en el que se revisaron las historias clínicas de los pacientes reintervenidos por sospecha de complicaciones después de la colecistectomía laparoscópica, en el período comprendido de enero de 1998 a junio de 2010. Durante el período de la investigación se realizaron 10 039 colecistectomías laparoscópicas. Fueron reintervenidos 23 pacientes (0,2 %, con una edad media de 49 años (rango 22 a 73 años, DE ± 10. La relaparoscopia fue la vía para la reintervención (70 % y solo 3 (13 % requirieron cirugía abierta. Fue la colangiopancreatografía retrógrada endoscópica un procedimiento útil para complementar la solución de algunas de estas complicaciones. El tiempo quirúrgico medio en las reintervenciones fue de 67 min (rango 30-120 min, la estadía hospitalaria tuvo una media de 4 y 5 días respectivamente. Hubo 2 pacientes (9 % que se reintervinieron tardíamente, a las 72 h de la colecistectomía, que fallecieron con cuadros de shock séptico. La laparoscopia es un procedimiento adecuado para las reintervenciones en pacientes con sospecha de complicaciones después de colecistectomía laparoscópica, con menor morbilidad y mortalidad sobre otros procederes, y su eficacia para el tratamiento de estas complicaciones está demostrada.Over past years some centers with experience in laparoscopic cholecystectomy have published the complications and treatment of this procedure. The aim of present paper is to describe the experience in 23 patients re-operated on due to

  18. Mastering Node.js

    CERN Document Server

    Pasquali, Sandro

    2013-01-01

    This book contains an extensive set of practical examples and an easy-to-follow approach to creating 3D objects.This book is great for anyone who already knows JavaScript and who wants to start creating 3D graphics that run in any browser. You don't need to know anything about advanced math or WebGL; all that is needed is a general knowledge of JavaScript and HTML. The required materials and examples can be freely downloaded and all tools used in this book are open source.

  19. Testing Backbone.js

    CERN Document Server

    Roemer, Ryan

    2013-01-01

    This book is packed with the step by step tutorial and instructions in recipe format helping you setup test infrastructure and gradually advance your skills to plan, develop, and test your backbone applications.If you are a JavaScript developer looking for recipes to create and implement test support for your backbone application, then this book is ideal for you.

  20. KnockoutJS essentials

    CERN Document Server

    Ferrando, Jorge

    2015-01-01

    If you are a JavaScript developer who has been using DOM manipulation libraries such as Mootools or Scriptaculous, and you want go further in modern JavaScript development with a simple and well-documented library, then this book is for you. Learning how to use Knockout will be perfect as your next step towards building JavaScript applications that respond to user interaction.

  1. Backbone.js cookbook

    CERN Document Server

    Mirgorod, Vadim

    2013-01-01

    Written in a friendly, example driven Beginner's Guide format, there are plenty of step-by-step instructions to get you started fast!Pentaho 4.0 By Example: Beginner's Guide is the ideal companion for a wide-variety of developers. Whether you are new to the world of Business Intelligence reporting, or an experienced BI analyst, this book will guide you through the creation of your first reports in Pentaho. We assume some knowledge of the SQL language and database systems.

  2. Backbone.js essentials

    CERN Document Server

    Walker, Jeremy

    2015-01-01

    If you are a developer with baseline JavaScript proficiency and are familiar with the jQuery library, then this book is ideal for you. Whether you've tried building complex web applications before and been frustrated by the challenge of doing so without the proper tools, or whether you've only built simple websites and are now looking to create full-featured web applications, this book has everything you need to get ahead of the curve.

  3. Efecto del número de aplicaciones de cloprostenol sobre la regresión de cuerpos lúteos, el retorno al celo y la ovulación, después de un tratamiento superovulatorio en donantes de embriones bovinos

    OpenAIRE

    C. Jiménez; R. Mapletoft; A. Tribulo; J. V. Garzón; Cabra C.; G. Bo

    2011-01-01

    El objetivo del presente trabajo fue evaluar la respuesta de la aplicación doble o triple de prostaglandina sobre la regresión de CL, ovulación y retorno al celo después de un tratamiento superovulatorio en vacas donantes de embriones. Para este experimento se tomaron 44 vacas asignadas al azar a dos grupos de tratamiento. Al primero (n = 23; CLO 0 & 7) se le aplicó una dosis de 500 μg de cloprostenol los días 0 (denominado día de la colecta) y 7; al segundo grupo (n = 21; CLO 0, 1 & 7) se le...

  4. 40 CFR 798.6500 - Schedule-controlled operant behavior.

    Science.gov (United States)

    2010-07-01

    ..., such as food or water (Ferster and Skinner, 1957 under paragraph (f)(2) of this section). For example....B. Skinner, B.F. Schedules of Reinforcement. (New York: Appleton-Century-Crofts, 1957). (3) Laties...

  5. Gamma radiation effects on chemical composition and color of raspberries (Rubus Idaeus L.) and blueberries (Vaccinium Corymbosum) cultivated in South of Chile

    International Nuclear Information System (INIS)

    Urbina P, M.C.; Manquian T, N.

    1988-01-01

    Raspberries and blueberries grown in the X th Region, Valdivia, were irradiated in a 137 Cs irradiador BPCDI (Brookhaven Portable Cesium Development irradiator) with dosis of 1,5 KGy and 2,5 KGy in order to measure the effect on the chemical composition and the changes of color due to pigments damage using a colorimetric method. Analysis of pH, soluble solids, titratable acidity, dry matter, total sugar and vitamin C were made. Color was analized comparing the pink color of the diluted fruit juice with a color scale of different concentrations of a cobalt scale of different concentrations of cobalt chloride. Results demonstrated that the radurization treatment does not affect chemical composition with dosis up to 2,5 KGy. It was possible to detect differences of color in raspberries and not in blueberries because of the less sensitivity of color pigments to radiation. (author)

  6. Possible Regulatory Improvements of the American Housing Finance System

    DEFF Research Database (Denmark)

    Lunde, Jens

    2018-01-01

    Book review of: Susan M. Wachter and Joseph Tracy (eds.): Principles of Housing Finance Reform. PENN—University of Pennsylvania Press, Philadelphia, 282 pp, $65.00s, ISBN: 978-0-8122-4862-3......Book review of: Susan M. Wachter and Joseph Tracy (eds.): Principles of Housing Finance Reform. PENN—University of Pennsylvania Press, Philadelphia, 282 pp, $65.00s, ISBN: 978-0-8122-4862-3...

  7. Cuentas y cultura material: La reconstrucción del Real Palacio de Lima después del terremoto de 1746

    Directory of Open Access Journals (Sweden)

    Walker, Charles

    2002-12-01

    Full Text Available This article is an analysis and transcription of an account book on the rebuilding of the Royal Palace of Lima, after the devastating earthquake of 1746. The document contains detailed information about the origin and costs of the work force and the products used in the rebuilding, information rarely found in documentation from the period. It thus offers a rich entryway into a number of important themes regarding eighteenth-century Peru. These include material culture, the life and death of slaves, and construction techniques. It contributes to the understanding of social and economic history of colonial Peru and more specifically to late colonial architecture and accounting, as well as the history of the Palace itself.

    Este artículo es un análisis y transcripción de un libro de cuentas referente a la reconstrucción del Palacio Real en Lima, después del devastador terremoto de 1746. El documento contiene detallada información sobre la procedencia y el costo de la mano de obra y los productos utilizados en dicha obra, información poco común en la documentación de la época. Ofrece así una entrada a una serie de temas importantes para el Perú del XVIII. Estos incluyen la cultura material, la vida y muerte de los esclavos, y las formas de construcción. Contribuye al conocimiento de la historia social y económica del Perú colonial y más específicamente a la arquitectura y la contaduría de la colonia tardía, y a la historia del mismo Palacio.

  8. Petrochemical Results for Volcanic Rocks recovered from SHINKAI 6500 diving on the Bonin Ridge (27°15'N-28°25'N): submarine extension of Ogasawara forearc volcanism

    Science.gov (United States)

    Bloomer, S. H.; Kimura, J.; Stern, R. J.; Ohara, Y.; Ishii, T.; Ishizuka, O.; Haraguchi, S.; Machida, S.; Reagan, M.; Kelley, K.; Hargrove, U.; Wortel, M.; Li, Y. B.

    2004-12-01

    Four SHINKAI 6500 submersible dives (dive #823 to #826) were performed along the Bonin Ridge escarpment west of Ogasawara (Bonin) Islands in the West Pacific during May 2004, in the hopes of finding exposures of lower crust of the IBM forearc. The Ogasawara Islands are located on the Bonin ridge, exposing 48-40 Ma boninites on Chichi-jima and depleted arc tholeiite lavas of the same age on Haha-jima. These extremely depleted lavas are believed to have been generated when subduction began beneath the Izu-Bonin-Mariana oceanic arc system. Subsequent rifting (35-30 Ma) formed the Bonin Trough and a 350 km long N-S trending eastern escarpment (Bonin Ridge), where we concentrated our dives. We observed lavas and volcaniclastic sequences by the four SHINKAI dives along the escarpment, and 16 fresh basaltic to andesitic lava samples have been recovered. The first three dives appear to have sampled volcanic constructs, of presumed Oligocene age, along the escarpment, whereas the last dive sampled exposures similar to Eocene rocks of the Bonin islands, including nummulitic limestone. The lava samples were analyzed by ICP-MS at Shimane University for 30 incompatible trace elements. All samples show arc-like chemical signatures, including elevated concentrations of LIL elements, depletions in Ta and Nb, and spikes in Pb, Sr, and Li. All samples show modest enrichments in LREE. A lava sample from the northernmost dive #824 is identical with the depleted tholeiite from Haha-jima Islands at the southernmost end of the Bonin Ridge in terms of trace element characteristics. Other lava samples from northern three dives (#823, #824, #825) have tholeiitic affinities with more elevated highly incompatible elements. This suggests derivation of the series of lavas by different degree of partial melting of a similar source mantle. Samples from southernmost dive site #826, immediately northwest of Chichi-jima Islands, are boninites with U-shaped REE patterns and relatively enriched Zr and

  9. La normalización de la descripción archivística en Gran Bretaña, EE.UU., Canadá, Portugal, Brasil y España después de ISAD(g: procesos y modelos de trabajo

    Directory of Open Access Journals (Sweden)

    Dunia LLanes Padrón

    2015-01-01

    Full Text Available Se estudian y contextualizan los procesos normativos desarrollados en los países que han publicado estándares después de la edición de ISAD(G: Gran Bretaña, EE.UU, Canadá, Portugal, Brasil y España (tanto a nivel nacional como en las comunidades de Castilla y León, Cataluña, Galicia y Aragón. En este sentido, se realiza una reflexión sobre la perspectiva histórica de la descripción en estas naciones y comunidades autonómicas, sistematizando las actividades realizadas hasta la publicación oficial de los estándares.

  10. Evaluación del eje hipotálamo hipófisis adrenal después de la quimioterapia de inducción en niños con Leucemia Linfoide Aguda (LLA) / Evaluation of the hypothalamo - pituitary- adrenal axis after induction chemotherapy in children with acute lymphoid leukemia (ALL)

    OpenAIRE

    Acevedo Sedano, Gizeth Lorena

    2011-01-01

    Antecedentes: La insuficiencia suprarrenal no ha sido en cuenta en los niños que reciben dosis altas de esteroides, como los de la quimioterapia de inducción para Leucemia Linfoide Aguda (LLA). Algunos autores han reportado una incidencia de disfuncion suprarrenal entre 46% a 81,5% en este grupo de pacientes. Objetivos: Evaluar la frecuencia de insuficiencia suprarrenal en pacientes pediátricos con LLA después de recibir quimioterapia de inducción que incluye esteroides a...

  11. IoT E-business applications

    Directory of Open Access Journals (Sweden)

    Radu BUCEA-MANEA-TONIS

    2017-09-01

    Modern E-business web applications are now developed using new technologies such as NodeJS, AngularJS and Bootstrap. The article identifies and solves practical issues regarding the JSON exchanged messages between NodeJS and AngularJS within SMEs E-business environment.

  12. Asociación entre el crecimiento bacteriano de la flora intestinal y la presión arterial de hombres adultos mayores hipertensos después de cinco semanas de consumo de soya (Glicine máx

    Directory of Open Access Journals (Sweden)

    Celia Rossi Trespalacios

    2014-01-01

    Full Text Available Objetivo: Objetivo: Determinar la asociación entre el crecimiento bacteriano de la flora intestinal y la presión arterial de hombres adultos mayores hipertensos después de cinco semanas de consumo de soya (Glicine máx. Materiales y métodos: Estudio cuasiexperimental para evaluar la asociación entre cambios en la presión arterial y el crecimiento bacteriano en 24 hombres hipertensos con edades entre 61 y 82 años residentes en el barrio Las Malvinas (suroccidente de Barranquilla, quienes adicionaron a su dieta habitual “leche de soya” de grano entero sin lactosa (18 gramos de proteína de soya por día durante 6 semanas. En el análisis microbiológico de las heces se determinaron los géneros y la cantidad de bacterias mediante técnicas tradicionales. Se midió la presión arterial al inicio y final del tratamiento. Resultados: Los recuentos de bacterias aeróbicas al inicio fueron 10 5 a 10 9 y al final 10 6 a 10 9 UFC/gramo de muestra; en bacterias anaeróbicas se encontraron los recuentos más altos: 10 5 a 10 9 antes y 10 6 a 1010 UFC/g al final. Después del tratamiento con soya la presión sistólica disminuyó en 37.5 % de los participantes, la diastólica en 16.67 %, la media en 45.83 % y la de pulso en 45.83 %; sin embargo, no hubo significancia estadística en ningún caso. El coeficiente de correlación de Pearson entre presión arterial y crecimiento bacteriano fue 0.14. Conclusiones: Se observó una asociación débil e inversa entre el incremento de la microbiota intestinal y la disminución de la presión arterial.

  13. Job Security as an Endogenous Job Characteristic

    DEFF Research Database (Denmark)

    Jahn, Elke; Wagner, Thomas

    This paper develops a hedonic model of job security (JS). Workers with hetero-geneous JS-preferences pay the hedonic price for JS to employers, who incur labor-hoarding costs from supplying JS. In contrast to the Wage-Bill Argument, equilibrium unemployment is strictly positive, as workers with w...

  14. La Convención de los Derechos del Niño veinte años después

    Directory of Open Access Journals (Sweden)

    Ligia Galvis Ortiz

    2009-01-01

    Full Text Available Este ensayo es una reflexión sobre la Convención los Derechos del Niño, con ocasión de sus veinte años de vigencia. El recorrido con el desarrollo de los antecedentes del reconocimiento de los derechos de los niños y niñas en el siglo XIX luego de que autores de la literatura universal como Charles Dickens y Jules Vallès presentaran en sus obras la situación de autoritarismo y maltrato, narrada a partir de sus experiencias. Estas narraciones abrieron el debate en Europa y en América Latina sobre los derechos, y es así como aparecen varios proyectos de Declaración anteriores a la Declaración de Ginebra aprobada por la Sociedad de las Naciones en1924. Estos proyectos se apoyan en el desarrollo conceptual de la nueva pedagogía que también abre sus telones en las últimas décadas del siglo XIX, y acompañan todo el devenir del debate hasta llegar a la aprobación de la Convención, que hoy consagra los derechos de las niñas, niños y adolescentes del planeta. Hago después el análisis de la influencia de ese legado libertario de la pedagogía nueva en el contenido de la Convención, a través de dos entidades centrales que son la titularidad de los derechos y la protección integral con los avances conceptuales que aportan elementos para una interpretación holística, dinámica y actual de la Convención, como son la perspectiva de género, la titularidad activa de los derechos de los niños y niñas, el reconocimiento del mundo de los niños y las niñas y las nuevas miradas sobre la discapacidad, elementos que le aportan un nuevo dinamismo y le imprimen actualidad a los postulados de la Convención.

  15. Comparing Non-Medical Sex Selection and Saviour Sibling Selection in the Case of JS and LS v Patient Review Panel: Beyond the Welfare of the Child?

    Science.gov (United States)

    Smith, Malcolm K; Taylor-Sands, Michelle

    2018-03-01

    The national ethical guidelines relevant to assisted reproductive technology (ART) have recently been reviewed by the National Health and Medical Research Council (NHMRC). The review process paid particular attention to the issue of non-medical sex selection, although ultimately, the updated ethical guidelines maintain the pre-consultation position of a prohibition on non-medical sex selection. Whilst this recent review process provided a public forum for debate and discussion of this ethically contentious issue, the Victorian case of JS and LS v Patient Review Panel (Health and Privacy) [2011] VCAT 856 provides a rare instance where the prohibition on non-medical sex selection has been explored by a court or tribunal in Australia. This paper analyses the reasoning in that decision, focusing specifically on how the Victorian Civil and Administrative Tribunal applied the statutory framework relevant to ART and its comparison to other uses of embryo selection technologies. The Tribunal relied heavily upon the welfare-of-the-child principle under the Assisted Reproductive Treatment Act 2008 (Vic). The Tribunal also compared non-medical sex selection with saviour sibling selection (that is, where a child is purposely conceived as a matched tissue donor for an existing child of the family). Our analysis leads us to conclude that the Tribunal's reasoning fails to adequately justify the denial of the applicants' request to utilize ART services to select the sex of their prospective child.

  16. La reputación de Chile, país minero: cinco años después del fenómeno mediático de los 33

    Directory of Open Access Journals (Sweden)

    Suescún, Verónica

    2017-07-01

    Full Text Available La minería en Chile tiene una historia ancestral, forma parte de su identidad como nación y es clave para su desarrollo. El sector tiene un rol primordial en la economía mundial, el país es proveedor líder de muchas materias primas especialmente asociadas al cobre, el litio y el potasio. En el 2010 la historia de 33 mineros que quedaron atrapados 700 metros bajo tierra generó un fenómeno mediático global, que registró una audiencia televisiva, radiofónica, en prensa digital y redes sociales de millones de personas en los cinco continentes. Sin duda, esta fue una experiencia de reputación que puso a la minería chilena en la agenda pública internacional. Cinco años después, ¿qué dicen los medios de comunicación del sector? Este documento presenta los resultados de la evaluación a la reputación mediática de la minería en Chile en el año 2014, a partir de los datos obtenidos mediante el análisis de contenido cuantitativo y cualitativo en diarios nacionales.

  17. Osteoradionecrosis related to mastication and parafunction

    Energy Technology Data Exchange (ETDEWEB)

    Marunick, M.T.; Leveque, F. (Wayne State Univ., Detroit, MI (USA))

    1989-11-01

    This article discusses mastication and parafunctional habits as possible etiologic factors in the development of osteoradionecrosis. From the three case reports presented it was noted that bone necrosis can occur after extended periods after radiation therapy, is seen most frequently in the mandible, and occurs most often at dosage levels exceeding 6500 rad. Recommendations after treatment to patients receiving 6500 rad or more should include caution regarding consistency of diet, use of existing prostheses, and the potential harmful effects of parafunctional habits.

  18. Osteoradionecrosis related to mastication and parafunction

    International Nuclear Information System (INIS)

    Marunick, M.T.; Leveque, F.

    1989-01-01

    This article discusses mastication and parafunctional habits as possible etiologic factors in the development of osteoradionecrosis. From the three case reports presented it was noted that bone necrosis can occur after extended periods after radiation therapy, is seen most frequently in the mandible, and occurs most often at dosage levels exceeding 6500 rad. Recommendations after treatment to patients receiving 6500 rad or more should include caution regarding consistency of diet, use of existing prostheses, and the potential harmful effects of parafunctional habits

  19. Abiquiu Dam and Reservoir, Rio Grande Basin, Rio Chama, New Mexico. Embankment Criteria and Performance Report.

    Science.gov (United States)

    1987-04-01

    EMBANKMENT CRITERIA AND PERFORMANCE REPORT PERTINENT DATA 1. General Data. LOCATION: Rio Arriba County, New Mexico, on the Rio Chama at river mile 33. PURPOSE...is located across the Rio Chama, approximately 30 miles upstream from its confluence with the Rio Grande, in Rio Arriba County, New Mexico. The dam is...6600- 4 i ’. 6600 65060- -60 6600- a + v6500s-go FA**v~w -6500 6300- 60 - ~ ~ ~ wo Ala filll------------------ EMBNKEN SECTION62 *LDN WOR SAFEL VAIE

  20. Enfisema subcutâneo pós-amigdalectomia: relato de caso Enfisema subcutáneo después de amigdalectomia: relato del caso Subcutaneous emphysema after tonsillectomy: case report

    Directory of Open Access Journals (Sweden)

    Walter Luiz Ferreira Lima

    2005-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A amigdalectomia é considerada um procedimento relativamente seguro. O objetivo deste relato foi mostrar uma complicação rara desta cirurgia, o enfisema subcutâneo. RELATO DO CASO: Paciente do sexo masculino, 25 anos, com amigdalite recorrente e hipertrofia de cornetos. Foi submetido a amigdalectomia e turbinectomia sob anestesia geral com intubação orotraqueal. A operação transcorreu sem intercorrências. Na sala de recuperação pós-anestésica (SRPA o paciente agitou-se, apresentando grande esforço físico. Quatro horas após a cirurgia, notou-se edema crepitante e depressível no pescoço e na região parotídea esquerda, característico de enfisema subcutâneo. A tomografia computadorizada mostrou a existência de ar nas regiões malar e cervical (principalmente à esquerda, atingindo até o mediastino superior. Não houve obstrução das vias aéreas e o estado geral do paciente permaneceu estável. Teve alta hospitalar no dia seguinte e foi acompanhado no ambulatório. O enfisema regrediu totalmente após 10 dias. CONCLUSÕES: O enfisema subcutâneo é uma complicação rara da amigdalectomia, ocorrendo quase sempre após dissecções profundas da mucosa faríngea, quando se cria interface porosa que proporciona a entrada do ar. O aumento da pressão nas vias aéreas superiores pode contribuir para o problema.JUSTIFICATIVA Y OBJETIVOS: La amigdalectomia se considera como un procedimiento relativamente seguro. El objetivo de este relato fue mostrar una complicación rara de esta cirugía, el enfisema subcutáneo. RELATO DEL CASO: Paciente del sexo masculino, 25 años, con amigdalitis recurrente e hipertrofia de cornetes. Fue sometido a amigdalectomia y turbinectomia bajo anestesia general con intubación orotraqueal. La operación transcurrió sin intercurrencias. En la sala de recuperación pos-anestésica (SRPA el paciente se agitó, presentando grande esfuerzo físico. Cuatro horas después de la

  1. Variable reluctance displacement transducer temperature compensated to 6500F

    International Nuclear Information System (INIS)

    1975-01-01

    In pressurized water reactor tests, compact instruments for accurate measurement of small displacements in a 650 0 F environment are often required. In the case of blowdown tests such as the Loss of Fluid Test (LOFT) or Semiscale computer code development tests, not only is the initial environment water at 650 0 F and 2200 psi but it undergoes a severe transient due to depressurization. Since the LOFT and Semiscale tests are run just for the purpose of obtaining data during the depressurization, instruments used to obtain the data must not give false outputs induced by the change in environment. A LOFT rho v 2 probe and a Semiscale drag disk are described. Each utilizes a variable reluctance transducer (VRT) for indication of the drag-disk location and a torsion bar for drag-disk restoring force. The VRT, in addition to being thermally gain and null offset stable, is fabricated from materials known to be resistant to large nuclear radiation levels and has successfully passed a fast neutron radiation test of 2.7 x 10 17 nvt without failure

  2. High levels of virus replication and an intense inflammatory response contribute to the severe pathology in lymphoid tissues caused by Newcastle disease virus genotype VIId.

    Science.gov (United States)

    Hu, Zenglei; Hu, Jiao; Hu, Shunlin; Song, Qingqing; Ding, Pingyun; Zhu, Jie; Liu, Xiaowen; Wang, Xiaoquan; Liu, Xiufan

    2015-03-01

    Some strains of Newcastle disease virus (NDV) genotype VIId cause more-severe tissue damage in lymphoid organs compared to other virulent strains. In this study, we aim to define the mechanism of this distinct pathological manifestation of genotype VII viruses. Pathology, virus replication, and the innate immune response in lymphoid tissues of chickens infected with two genotype VIId NDV strains (JS5/05 and JS3/05), genotype IX NDV F48E8 and genotype IV NDV Herts/33, were compared. Histopathologic examination showed that JS5/05 and JS3/05 produced more-severe lesions in the spleen and thymus, but these four virulent strains caused comparable mild lesions in the bursa. In addition, JS3/05 and JS5/05 replicated at significantly higher levels in the lymphatic organs than F48E8 and Herts/33. A microarray assay performed on the spleens of chickens infected with JS5/05 or Herts/33 revealed that JS5/05 elicited a more potent inflammatory response by increasing the number and expression levels of activated genes. Moreover, cytokine gene expression profiling showed that JS5/05 and JS3/05 induced a stronger cytokine response in lymphoid tissues compared to F48E8 and Herts/33. Taken together, our results indicate that the severe pathology in immune organs caused by genotype VIId NDV strains is associated with high levels of virus replication and an intense inflammatory response.

  3. Optimización de la estadificación clínico-patológica mediante la utilización del aclaramiento anglionar después del estudio de patología convencional en piezas quirúrgicas de pacientes con cáncer de colon y recto

    OpenAIRE

    Lombana Amaya, Luis Jorge

    2010-01-01

    Objetivo: Establecer las ventajas de la técnica de aclaramiento ganglionar como método complementario para la detección de ganglios linfáticos en el estudio anatomopatológico de especímenes quirúrgicos de pacientes con cáncer colo-rectal. Diseño: Estudio observacional descriptivo prospectivo. Lugar y población: Pacientes llevados a cirugía por cáncer colo-rectal en el Hospital Universitario San Ignacio y la Clínica Nueva entre Julio de 2009 y Diciembre de 2009. Intervención y medición: despué...

  4. Skoda JS in 2016

    International Nuclear Information System (INIS)

    Perlik, Josef

    2016-01-01

    The presentation describes the main areas of activities of the company, which are: Engineering: Construction of WWER rectors; Modernization and reconstruction of units with WWER (including replacement of control systems); spent fuel storage facilities; Construction of research and training reactors; Production: Equipment for nuclear power plants with WWER and RBMK reactors; Equipment for nuclear power plants with reactor type PWR and BWR; The equipment for storage of spent nuclear fuel; Equipment for the petrochemical industry projects Service: Planned maintenance management; Maintenance and repair of the reactor equipment; Upgrading reactor components; life management for equipment

  5. Número de ganglios linfáticos metastásicos como determinante de los resultados después de prostatectomía radical de rescate para el cáncer de próstata de radiación recurrente

    Science.gov (United States)

    Gugliemetti, G; Sukhu, R; Conca Baenas, M A.; Meeks, J; Sjoberg, D D.; Eastham, J A.; Scardino, P T.; Touijer, K

    2017-01-01

    Resumen Antecedentes La presencia de metástasis en los ganglios linfáticos (MGL) en la prostatectomía radical de rescate (PRs) se asocia con un mal pronóstico. Los factores predictivos de resultados en este contexto siguen siendo indeterminados. El objetivo fue evaluar el papel de número de ganglios linfáticos positivos sobre el resultado de los pacientes con MGL después de PRs y para el cáncer de próstata de radio-recurrente. Material y métodos Se analizaron los datos de una cohorte consecutiva de 215 hombres tratados con PRr en una sola institución. Se utilizaron los modelos de regresión de riesgos proporcionales de Cox univariante para la recurrencia bioquímica (RBQ) y los resultados metastásicos, con el antígeno prostático específico, la puntuación de Gleason, la extensión extraprostática, la invasión de vesículas seminales, el tiempo entre la terapia de radiación y PRr y el número de ganglios positivos como factores predictivos. Resultados De los 47 pacientes con MGL, 37 desarrollaron RBQ, 11 desarrollaron metástasis a distancia y 4 fallecieron con una mediana de seguimiento de 2,3 años para los supervivientes. El riesgo de metástasis aumentó con mayores niveles preoperatorios de PSA (HR 1,19 por 1 ng/ml; IC del 95%: 1,06, 1,34; p = 0,003). Los factores predictivos restantes no alcanzaron niveles convencionales de significación. Sin embargo, la eliminación de 3 o más ganglios linfáticos positivos demostró una asociación positiva, como se esperaba, con enfermedad metastásica (HR 3,44, IC: 0,91, 13,05; p = 0,069) en comparación con uno o dos ganglios positivos. Del mismo modo, la presencia de extensión extraprostática, invasión de vesículas seminales y grado de Gleason superior a 7 también demostraron una asociación positiva con un mayor riesgo de metástasis, con índices de riesgo de 3,97 (IC del 95% 0,50; 31,4; p = 0,2), 3,72 (IC 95% 0,80, 17,26; p = 0,1) y 1,45 (IC del 95% 0,44, 4,76; p = 0,5), respectivamente

  6. La neutralidad como problema y como solución. La política gremial del Partido Socialista después de la ruptura sindicalista

    Directory of Open Access Journals (Sweden)

    Ricardo Martínez Mazzola

    2011-12-01

    Full Text Available En este artículo nos preguntamos por el modo en que el Partido Socialista argentino planteó el vínculo entre acción gremial y acción política. Nuestro recorrido se abre reconstruyendo las polémicas sobre la cuestión que tuvieron lugar en los primeros grupos socialistas, que alcanzaron un punto de gran visibilidad en la “ruptura sindicalista”. Pasamos luego a señalar que, aunque la expulsión de los sindicalistas no cerró el debate, el triunfo de la postura de Juan B. Justo, favorable a la “autonomía” entre partido y organización gremial, hizo posible la permanencia de los socialistas en una organización sindical que no controlaban. A continuación mostramos que esa convivencia se mantuvo durante los primeros años del gobierno de Hipólito Yrigoyen, momento en que la postura de “autonomía” adquirió su fórmula canónica. Sin embargo, como mostramos luego, los problemas implícitos en el postulado neutralista se hicieron visibles poco tiempo después, cuando los “socios” sindicalistas comenzaron a establecer un vinculo privilegiado con los radicales, adversarios del Partido Socialista en el terreno político. En las reflexiones finales proponemos pensar la fórmula neutralista como una respuesta a lo que Juan Carlos Torre ha definido como una situación de disociación entre los terrenos de lucha gremial y lucha política.

  7. Desenvolupament d'aplicació web amb integració contínua

    OpenAIRE

    Comas Torres, Diego

    2015-01-01

    Desenvolupament d'una aplicació web d'enquestes amb integració contínua amb tecnologies Jenkins, TDD i JavaScript com Node JS, Angular JS i MongoDB. Desarrollo de una aplicación web de encuestas con integración continua con tecnologías Jenkins, TDD y JavaScript como Node JS, Angular JS y MongoDB. Bachelor thesis for the Computer Science program.

  8. Non-visual effects of light on melatonin, alertness and cognitive performance: can blue-enriched light keep us alert?

    Directory of Open Access Journals (Sweden)

    Sarah Laxhmi Chellappa

    Full Text Available BACKGROUND: Light exposure can cascade numerous effects on the human circadian process via the non-imaging forming system, whose spectral relevance is highest in the short-wavelength range. Here we investigated if commercially available compact fluorescent lamps with different colour temperatures can impact on alertness and cognitive performance. METHODS: Sixteen healthy young men were studied in a balanced cross-over design with light exposure of 3 different light settings (compact fluorescent lamps with light of 40 lux at 6500K and at 2500K and incandescent lamps of 40 lux at 3000K during 2 h in the evening. RESULTS: Exposure to light at 6500K induced greater melatonin suppression, together with enhanced subjective alertness, well-being and visual comfort. With respect to cognitive performance, light at 6500K led to significantly faster reaction times in tasks associated with sustained attention (Psychomotor Vigilance and GO/NOGO Task, but not in tasks associated with executive function (Paced Visual Serial Addition Task. This cognitive improvement was strongly related with attenuated salivary melatonin levels, particularly for the light condition at 6500K. CONCLUSIONS: Our findings suggest that the sensitivity of the human alerting and cognitive response to polychromatic light at levels as low as 40 lux, is blue-shifted relative to the three-cone visual photopic system. Thus, the selection of commercially available compact fluorescent lights with different colour temperatures significantly impacts on circadian physiology and cognitive performance at home and in the workplace.

  9. Job Security as an Endogenous Job Characteristic

    DEFF Research Database (Denmark)

    Jahn, Elke; Wagner, Thomas

    JS-preferences trade JS for higher wages. The relation between optimal job insecurity and the perceived dismissal probability is hump-shaped. If firms observe demand, but workers do not, separation is not contractible and firms dismiss workers at-will. Although the workers are risk-averse......, they respond to the one-sided private information by trading wage-risk for a higher JS. With two-sided private information, even JS-neutral workers pay the price for a JS guarantee, if their risk premium associated with the wage-replacement risk is larger than the social net loss from production....

  10. Los nuevos canales de Televisión Digital Terrestre en España. Reconfiguración de la oferta televisiva en abierto dos años después del encendido digital

    Directory of Open Access Journals (Sweden)

    Costa Sánchez, Carmen

    2012-12-01

    Full Text Available En español: La evolución del medio televisivo en nuestro país ha tenido como última etapa el apagón analógico y el consecuente nacimiento de múltiples programas que nutren la oferta de la Televisión Digital. En el presente artículo se analiza la reconfiguración de la oferta de Televisión Digital Terrestre (TDT en España después de la aprobación del Real-Decreto 365/2010 para asignar los múltiples de la TDT una vez finalizadas las emisiones analógicas In english: The evolution of television in our country has had like last stage the analogue switch off and the birth of multiple programs that nourish the offer of the Digital Television. In the present article we analyze the reconfiguration of the offer of Terrestrial Digital Television (TDT in our country, after the approval of the Real-Decree 365/2010 to assign the multiple of the TDT once finalized the analog broadcasts.

  11. Decommissioning of an Irradiator MPX-{gamma} - 25M and a neutron Irradiator; Desmantelamiento de un irradiador tipo MPX-{gamma}-25M y de un irradiador de neutrones

    Energy Technology Data Exchange (ETDEWEB)

    Soguero, Dania; Guerra, Mercedes; Prieto, Enrique; Desdin, Luis, E-mail: sdania@ceaden.edu.cu [Centro de Aplicaciones Tecnologica y Desarrollo Nuclear (CEADEN), La Habana (Cuba)

    2013-07-01

    In this paper a technology is developed with its procedures in radiation protection to ensure the safety of the process of decommissioning of two irradiators. Both processes are described, the process of decommissioning of a neutron Irradiator 4. 44{center_dot}10{sup 11}Bq, employed in the vegetal radio mutagenesis, and disassembling of an installation of gamma irradiation of 3.33 * 10{sup 12} Bq, self-shielded of category I, model MPX - {gamma} - 25 M. The specific objectives are: a) identify aspects of the contractual assurance, of human and technical resources, b) to evaluate the radiological situation of the process and c) analyze the potential radiological extraordinary events in each of the steps of the process, ensuring the right answers. Evaluation of radiological successful events described can be considered as reference to address the process of disassembling of other similar irradiators.

  12. ¿Creen haber cambiado los docentes un año después de un curso de docencia clínica?

    Directory of Open Access Journals (Sweden)

    Pedro Herskovic

    Full Text Available Introducción. Los cursos de formación pedagógica pueden mejorar el desempeño de los docentes clínicos. Diseñamos un curso de diez sesiones para mejorar las competencias docentes de profesionales que tienen responsabilidades como tutores clínicos. En el año 2008 se realizaron tres cursos. Las actividades se programaron una vez a la semana, de 08:30 a 10:00 h de la mañana, para facilitar la asistencia. El curso se componía de tres módulos -currículo, metodología y evaluación- y se diseñó para centrarse en los alumnos. Fueron facilitadores de los cursos docentes clínicos con formación en docencia en ciencias de la salud (con diploma o maestría. Objetivo. Evaluar si los asistentes percibían haber realizado cambios en sus prácticas docentes a un año de haber finalizado el curso. Sujetos y métodos. Se administró de modo anónimo, mediante una plataforma informática, un cuestionario con 13 preguntas cerradas y espacio para comentarios. Se envió por correo electrónico una invitación a responder el cuestionario a los 55 tutores clínicos que fueron alumnos de los tres cursos realizados durante el año 2008. El cuestionario se remitió un año después de haber finalizado el curso respectivo. Resultados. El cuestionario fue respondido por 41 tutores clínicos (74,5%. Las respuestas apuntaron a cambios realizados en todos los aspectos consultados: programas (34%, metodología (83% y evaluación (71%. Conclusiones. La mayoría de los participantes en estos cursos de formación docente perciben haber hecho cambios positivos en sus prácticas docentes. Actualmente se está dictando el noveno curso de estas características.

  13. Proposed efficient method for ticket booking (PEMTB) | Ahmed ...

    African Journals Online (AJOL)

    Journal of Fundamental and Applied Sciences. Journal Home ... We used angular JS, ionic for a front end and node.js, express.js for a back end and mongo DB for a database. ... Our proposed system is totally softcopy and in digitalized.

  14. The CERN's year

    International Nuclear Information System (INIS)

    Chadli, M.; Coppier, H.; Pezzeti, M.

    2007-01-01

    CERN, the European organization for nuclear research, has just celebrated its fifty years of existence. Its first goal was to counterbalance the migration of physics scientists towards the USA by the creation of a physics laboratory gathering scientists from the different European countries. Today, the CERN's mission has changed and has overcome all the expectations of its founders. In 2008, it will become, with the LHC (Large Hadron Collider), the biggest particle accelerator in the world. The CERN employs about 3000 physicists, engineers, technicians and workers. There is also 6500 people from 80 different countries who use the CERN's facilities during the year. The CERN is controlled by 20 European member states and 6 observer countries, and 20 non-member countries participate to the programs in progress. The CERN's power comes from its international and cosmopolitan spirit. The whole most famous physicists of the world can work together for the progress of science and for a better understanding of matter, of its interactions and of our universe. Two Nobel prices of physics come from the CERN: C. Rubbia and S. Van der Meer in 1983 for the discovery of W + , W - and Z 0 bosons, and G. Charpak for the development of particle detectors. One can foresee that the LHC will allow new scientific achievements, like for instance, during experiments for the quest of the famous Higgs boson. It is important also to mention that the CERN has been at the origin of several technological innovations in all technical and engineering domains in the framework of its fundamental physics researches. (J.S.)

  15. Susceptibilidad canina a rabia después de una campaña de vacunación en zonas endémicas del Perú

    Directory of Open Access Journals (Sweden)

    Ricardo López I

    2007-01-01

    Full Text Available Objetivo: Determinar el nivel de la respuesta inmune posterior a una campaña de vacunación antirrábica canina en dos zonas que han presentado en los últimos años casos de rabia canina. Materiales y métodos: Se realizó una encuesta serológica, en 101 y 199 canes localizados en los distritos de Tambo Grande (Piura y Juliaca (Puno respectivamente y se efectuó la prueba del seroneutralización en ratón para determinar la proporción de canes con anticuerpos protectores (¡Ý 0,5 UI/mL según zona de estudio, antecedentes de vacunación, edad del perro y sexo. Resultados: Después de tres meses de la campaña antirrábica 32% del total de canes estuvieron protegidos adecuadamente, 66% tuvieron antecedentes de vacunación y 44% de los canes vacunados tenían anticuerpos ( 0,1 UI/mL. En Juliaca se encontró mayor protección, contra la rabia, que en Tambo Grande en los perros vacunados (51% frente a 34%, p<0,05. Los canes mayores de un año estaban más protegidos que los menores de un año (p<0,01, sin embargo el sexo del perro no tuvo relación con la protección (p0,05. Conclusiones: Existe una deficiente protección inmune contra la rabia en los distritos de Tambo Grande y Juliaca, lo cual hace estas zonas muy susceptibles a desarrollar brotes de rabia canina.

  16. Обзор графических javascript-библиотек для создания интерактивных электронных изданий

    OpenAIRE

    ЛАЗАРЕВА ОЛЬГА ЮРЬЕВНА; ЛОЖКИНА ДАРЬЯ ДМИТРИЕВНА

    2016-01-01

    В работе рассматриваются графические библиотеки JavaScript, такие как Two.js, SVG.js, Snap.svg, D3.js, Jim Knopf, Walkway.js, Vivus.js, Interact.js, и возможности их использования в Adobe Digital Publishing Solution для добавления интерактивности электронным изданиям.

  17. Escribir después del desastre: Violencia y testimonio en dos novelas de Álvaro Bisama

    Directory of Open Access Journals (Sweden)

    Natalia Alejandra Anabalon

    2016-08-01

    Full Text Available La escritura del escritor y académico chileno Álvaro Bisama Mayné empieza después del desastre, puede ser un huracán que está por venir, un incendio gigantesco en algún cerro de Valparaíso o lo que queda fuera de una fotografía.   El autor ha incursionado desde crítica literaria, el ensayo, la novela y la crónica buscando evidenciar la cultura moderna como desecho, el vacío de las personas, las relaciones humanas, la degradación y la violencia. En el siguiente ensayo me propongo analizar las distintas manifestaciones de la violencia y el testimonio, para ello se escogí las novelas Estrellas Muertas (2010 y Ruido (2012 siendo la primera un espejo de los hijos de la transición política de Chile post dictadura. Mientras que en  Ruido el autor vuelve al Chile convulsionado en el horror político y social de la Dictadura Militar de Augusto Pinochet cuando entre los años de 1983 y 1988 un joven huérfano dijo comunicarse con la Virgen María, posteriormente se lo conocería a él como Karol Romanov. Aquí deseo postular que son las mujeres quienes pueden contar la historia, quienes vuelven de lugares insospechados mientras que los hombres pasan deambulando en el relato, ambas novelas entregan una particular, para ello se harán dialogar las posturas de dos investigadoras argentinas, la primera es Pilar Calveiro (“Poder y Desaparición. Los campos de concentración en Argentina”. 1998 quien permite entender esta novela como un ejercicio de memoria estableciendo que tanto mujeres como hombres tienen distintas maneras de testimoniar sosteniendo que el hombre es más preciso para dar datos como nombres y lugares y pese a lo cruento de la experiencia logra ser objetivo; por el contrario, la mujer que da información entra en vivencia iniciado el acto del recuerdo. A continuación seguirá el planteamiento de Nora Strejilevich, (“El arte de no olvidar: literatura testimonial en Chile, Argentina y Uruguay, entre los 80 y los 90

  18. The relationship between emotional intelligence and job stress in the faculty of medicine in Isfahan University of Medical Sciences

    Directory of Open Access Journals (Sweden)

    NIKOO YAMANI

    2014-01-01

    Full Text Available Introduction: health care professionals especially clinicians, undergo lots of job stress (JS. Emotional intelligence (EI is among the variables that appear to be associated with stress. It is also included among the ways adopted by the individuals in order to resist JS in the workplace. Thus, this study aims to investigate the relationship between EI and JS in the faculty members of Isfahan University of Medical Sciences (IUMS. Methods: This was a correlational study performed on 202 faculty members of IUMS. The data was gathered through two valid and reliable questionnaires (Bradberry EI questionnaire and JS questionnaire, being analyzed by SPSS software using descriptive statistics, Pearson correlation coefficient, t-test, analysis of variance (ANOVA and linear regression analysis (α=0.05. Results: 142 individuals (70.30% filled out the questionnaires. 75% of the respondents were male and 98% were married. There was an inverse correlation between the total score of EI and the level of JS (r=-0.235, p=0.005. Moreover, among the factors of EI, self-awareness and self-management scores had significant inverse relationship with the level of JS. Linear regression analysis showed that the EI factors explained approximately 7% of the variance of JS levels of the teachers. Conclusions: Individuals with high EI have less JS. Since the EI can be taught, it can be expected that the JS of faculty members can be reduced through training them on emotional intelligence. Therefore, it is recommended that short-term training courses be scheduled and designed based on the concepts of EI for teachers, particularly clinicians.

  19. Capacidad de recuperación de 23 accesiones de Leucaena spp. después de la poda Recovery capacity of 23 Leucaena spp. accessions after pruning

    Directory of Open Access Journals (Sweden)

    Hilda B Wencomo

    2011-03-01

    Full Text Available Se evaluaron 23 accesiones de Leucaena spp. durante dos años, con el objetivo de conocer la variabilidad existente en la población en cuanto a la capacidad de recuperación después de la poda. Cuando las plantas sobrepasaban los 2 m, se realizó la poda de uniformidad a un 1 m de altura sobre el nivel del suelo. Las mediciones fueron: el grosor del tallo, el número de rebrotes y su longitud con una frecuencia semanal, a partir de lo cual se calculó la velocidad de crecimiento de cada accesión; además se determinó el rendimiento. El análisis de componentes principales, el de conglomerados y el de regresión lineal simple se realizaron a través del programa estadístico SPSS versión 11.5 para Microsoft Windows®. Se observó variabilidad en los indicadores evaluados (86,11% acumulado en la componente y todos contribuyeron a su explicación. A su vez, el análisis de conglomerados permitió la formación de tres grupos. Se concluye que todas las accesiones presentaron capacidad de recuperación después de la poda, con diferencias entre ellas. Las accesiones Leucaena leucocephala cv. Cunningham, cv. Perú, CIAT-9119, CIAT-9438, CIAT-751, CIAT-7988, CIAT-7384, CIAT-7929, CIAT-17480, cv. Ipil-Ipil y cv. CNIA-250; L. lanceolata CIAT-17255 y CIAT-17501 y L. diversifolia CIAT-17270 fueron las de mayor capacidad de recuperación. Por ello se recomienda, en futuras investigaciones relacionadas con la caracterización, evaluación y selección de estas especies, realizar estudios que incluyan su persistencia en el tiempo bajo condiciones de poda, así como su empleo en el fomento de nuevos sistemas silvopastoriles.Twenty three Leucaena spp. accessions were evaluated for two years, in order to know the variability existing in the population regarding the recovery capacity after pruning. When the plants were higher than 2 m, the uniformity pruning was made at 1 m above the soil level. The measurements were: stem diameter, number of regrowths and

  20. Isolation and characterization of bacteria capable of degrading polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides from PAH-contaminated soil in Hilo, Hawaii.

    Science.gov (United States)

    Seo, Jong-Su; Keum, Young-Soo; Harada, Renee M; Li, Qing X

    2007-07-11

    Nineteen bacterial strains were isolated from petroleum-contaminated soil in Hilo, HI, and characterized by two different spray-plated methods, turbidity test in liquid medium, and 16S rRNA gene sequence analysis. Analysis of the soil showed 13 polycyclic aromatic hydrocarbons (PAHs) in a range from 0.6 to 30 mg/kg of dry weight each and 12 PAH metabolites. Five distinct bacterial strains (C3, C4, P1-1, JS14, and JS19b1) selected from preliminary plating and turbidity tests were further tested for PAH degradation through single PAH degradation assay. Strains C3, C4, and P1-1 degraded phenanthrene (40 mg/L) completely during 7 days of incubation. Strain JS14 degraded fluoranthene (40 mg/L) completely during 10 days of incubation. Strain JS19b1 degraded 100% of phenanthrene (40 mg/L) in 7 days, 77% of fluorene (40 mg/L) in 14 days, 97% of fluoranthene (40 mg/L) in 10 days, and 100% of pyrene (40 mg/L) in 14 days. Turbidity tests showed that strains P1-1, JS14, and JS19b1 utilized several organophosphorus pesticides as growth substrate. P1-1 can degrade carbofenothion, chlorfenvinphos, diazinon, fonofos, and pirimiphos-methyl. JS14 can transform chlorfenvinphos and diazinon. JS19b1 can break down diazinon, pirimiphos-methyl, and temephos.

  1. Validation of general job satisfaction in the Korean Labor and Income Panel Study.

    Science.gov (United States)

    Park, Shin Goo; Hwang, Sang Hee

    2017-01-01

    The purpose of this study is to assess the validity and reliability of general job satisfaction (JS) in the Korean Labor and Income Panel Study (KLIPS). We used the data from the 17th wave (2014) of the nationwide KLIPS, which selected a representative panel sample of Korean households and individuals aged 15 or older residing in urban areas. We included in this study 7679 employed subjects (4529 males and 3150 females). The general JS instrument consisted of five items rated on a scale from 1 (strongly disagree) to 5 (strongly agree). The general JS reliability was assessed using the corrected item-total correlation and Cronbach's alpha coefficient. The validity of general JS was assessed using confirmatory factor analysis (CFA) and Pearson's correlation. The corrected item-total correlations ranged from 0.736 to 0.837. Therefore, no items were removed. Cronbach's alpha for general JS was 0.925, indicating excellent internal consistency. The CFA of the general JS model showed a good fit. Pearson's correlation coefficients for convergent validity showed moderate or strong correlations. The results obtained in our study confirm the validity and reliability of general JS.

  2. Una evaluación crítica sobre la calidad de la democracia en Costa Rica después de 1980: crisis económica, desintegración social y cambio político

    Directory of Open Access Journals (Sweden)

    Kjersti Sirevaag

    2011-07-01

    Full Text Available : Los estudios sobre calidad democrática son importantes por múltiples razones. En primer lugar, porque más sistemas políticos en el mundo han consolidado sus democracias. En segundo lugar, los estudios de calidad democrática pueden complementar los estudios de cambios políticos etiquetados como “transición” y “consolidación”. En tercer lugar, si la conceptualización y aplicación de calidad democrática se mejora, el concepto puede ser utilizado para optimizar las nuevas, y en algunos casos frágiles, democracias y así evitar que se desarrollen en una dirección no-democrática. El objetivo de este ensayo es construir un marco teórico que permita un estudio del desarrollo de la calidad democrática en Costa Rica después de 1980, analizando en qué grado las variables independientes concernientes a aspectos económicos, sociales, judiciales y políticos de Costa Rica pueden explicar los cambios en las dimensiones de calidad democrática

  3. Desarrollo de una red social para el aprendizaje

    OpenAIRE

    Cumbreras Tirado, Edgar

    2015-01-01

    En este trabajo de fin de grado se ha desarrollado una plataforma online que promociona y promueve el aprendizaje de nuevas tecnologías. La plataforma ha sido enteramente creada haciendo uso de JavaScript, con tecnologías como Node.js y Angular.js. En aquest treball de fi de grau s'ha desenvolupat una plataforma online que promociona i promou l'aprenentatge de noves tecnologies. La plataforma ha estat enterament creada fent ús de JavaScript, amb tecnologies com Node.js i Angular.js. Bac...

  4. El sistema de partidos colombiano hoy. Partidos y representación en el Congreso después de la reforma de 2003

    Directory of Open Access Journals (Sweden)

    Nadia Jimena Pérez Guevara

    2011-11-01

    Full Text Available La reforma política del año 2003 es la primera y más importante que en materia electoral se ha hecho después de la Constitución de 1991. Con el fenómeno de las microempresas electorales, la operación avispa y la profundización de la personalización política, se planteó la necesidad de hacer una reforma encaminada a reorganizar el sistema y los partidos políticos con dos cambios fundamentales: la fórmula electoral y el umbral (barrera electoral. Desde que se aprobó la reforma se han realizado cuatro elecciones en Colombia, dos del ámbito regional (Asambleas y Consejos en 2003 y 2007 y dos nacionales (Senado y Cámara de Representantes en 2006 y 2010, las cuales han vislumbrado efectos mecánicos sobre el sistema de partidos, tanto en el nivel nacional como subnacional, y han reorganizado las fuerzas políticas que compiten en cada legislatura. A la luz de la reforma el objetivo del artículo es observar los efectos de las reformas sobre el sistema de partidos del ámbito nacional, específicamente sobre la representatividad del sistema. Se analizan las elecciones a Congreso de los años 2006 y 2010 teniendo en cuenta su contexto y coyuntura política. Se concluye que el cambio de la fórmula electoral y la imposición de la barrera electoral lograron reorganizar a los partidos y, por ende, la competencia política sin afectar la representación del sistema, tal y como lo llegaron a plantear sus detractores. Pese a que este aspecto no tuvo una variación importante, factores como la densidad electoral llevan a plantear otro tipo de interrogantes frente al sistema electoral colombiano, como la necesidad, o no, de pensar una nueva reforma que apunte hacia un cambio en las circunscripciones electorales y, por tanto, en los niveles de representación del sistema.

  5. Deformidad facial postraumática asociada a complicación por silastic orbitario 35 años después de implantado

    Directory of Open Access Journals (Sweden)

    Denia Morales Navarro

    Full Text Available Las alteraciones esqueléticas del macizo facial sin tratamiento quirúrgico o con un manejo inadecuado, pueden resultar en deformidad secundaria importante con implicaciones estéticas y funcionales que deben ser consideradas para su tratamiento. El objetivo de esta presentación fue caracterizar el caso de deformidad facial postraumática asociada a complicación por silastic orbitario, 35 años después de implantado este. Se trata de un paciente masculino de 67 años que refirió haber sido tratado al presentar enrojecimiento de un ojo y secreciones. Refiere que hace 35 años fue intervenido quirúrgicamente por fractura “en la zona del ojo izquierdo”, que le colocaron silastic, y que no había tenido problemas hasta el momento en esa área. En el examen físico facial se detectó asimetría facial: ligero enoftalmo del ojo izquierdo, con desnivel pupilar, disminución de la apertura palpebral, rasgo antimongoloide, con eritema de la conjuntiva, quémosis, y abundantes secreciones. Se comprobó limitación del movimiento súpero-externo. Se corrobora la presencia de una fístula en el fondo de saco del párpado inferior. Se diagnostica como deformidad facial postraumática complicada por reacción a cuerpo extraño (al silastic. Fue intervenido quirúrgicamente y se realizó la exéresis del material, y la reconstrucción de la antomía ausente en la zona con malla de titanio. Se obtuvo excelentes resultados. Las lesiones postraumáticas de la cara se asocian generalmente con grandes secuelas funcionales y estéticas. Si se añaden las complicaciones por el empleo de implantes de biomateriales, la determinación de la conducta terapéutica puede ser un reto.

  6. Indução anestésica após o tratamento do choque hemorrágico: estudo experimental comparando a cetamina e o etomidato Inducción anestésica después del tratamiento del choque hemorrágico: estudio experimental eomparando la cetamina y el etomidato Anesthetic induction after treated hemorrhagic shock: experimental study comparing ketamine and etomidate

    Directory of Open Access Journals (Sweden)

    Adilson O. Fraga

    2006-08-01

    áveis em todos os grupos. CONCLUSÕES: O etomidato ou a cetamina foram capazes de manter a estabilidade hemodinâmica nos cães que sofreram choque hemorrágico intenso e que foram tratados com NaCl a 0,9% ou NaCl a 7,5%.JUSTIFICATIVA Y OBJETIVOS: El sangramiento que conlleva al choque hemorrágico generalmente necesita un tratamiento quirúrgico bajo anestesia general. A su vez, los anestésicos pueden comprometer más las condiciones hemodinámicas. El objetivo de este estudio fue el de comparar los efectos hemodinámicos de la cetamina y del etomidato durante la inducción anestésica en perros sometidos a un modelo experimental de choque hemorrágico y reanimación. MÉTODO: Treinta y dos perros mestizos fueron sometidos al choque hemorrágico presión-controlada, reanimación e inducción anestésica. Después de alcanzar la presión objeto de 40 mmHg ellos fueron divididos aleatoriamente en dos grupos de acuerdo con el líquido usado en la resucitación: NaCl a 0.9% (32 mL.kg-1 y NaCl a 7,5% (4 mL.kg-1. Después de la infusión de volumen, esos grupos fueron divididos nuevamente de acuerdo con el anestésico utilizado: GI NaCl a 0.9% y cetamina; GII NaCl a 7.5% y cetamina; GIII NaCl a 0.9% y etomidato; y GIV NaCl a 7.5% y etomidato. Mediciones hemodinámicas fueron obtenidas en cinco momentos: (M0 inicial; (M1 después del desarrollo del choque hemorrágico; (M2 después de la administración de soluciones; (M3 5 minutos después de la inducción anestésica; (M4 15 minutos después de la inducción anestésica. Se hizo el análisis estadístico usando el Student t test y two-way ANOVA. Fueron considerados significativos valores de p menores que 0,05. RESULTADOS: Después de la instalación del choque, los dos sueros reestablecieron los estándares hemodinámicos a los valores iniciales. Independiente del anestésico o del solución utilizada, después de la inducción anestésica la presión arterial media permaneció inalterada en todos los grupos. La presi

  7. Effects of treatment of periparturient dairy cows with recombinant bovine somatotropin on health and productive and reproductive parameters.

    Science.gov (United States)

    Silva, P R B; Soares, H F; Braz, W D; Bombardelli, G D; Clapper, J A; Keisler, D H; Chebel, R C

    2017-04-01

    The objectives of the current experiment were to evaluate the effects of treating periparturient dairy cows with recombinant bovine somatotropin (rbST) on incidence of postpartum diseases and performance. Holstein (HO) and Jersey (JS) cows from 2 herds were enrolled in the experiment at 253 ± 3 d of gestation and assigned to the control (n = 432) and rbST125 (n = 437) treatments. Cows in the rbST125 treatment received 125 mg of rbST, weekly, from -21 to 21 d relative to calving. Blood sampled weekly, from -21 to 21 d relative to calving, from a subsample of cows was used to determine the concentrations of growth hormone (GH, HO = 106) and insulin-like growth factor 1 (IGF-1, HO = 147 and JS = 49). Cows were scored for body condition (BCS) at enrollment and at 1 ± 3, 30 ± 3, and 60 ± 3 d in milk (DIM). Cows were milked thrice daily and energy-corrected milk (ECM) yield was recorded for the first 30 DIM. Treatment of cows with rbST resulted in greater concentrations of GH during the prepartum (log 10 back-transformed concentrations of GH: HO-control = 7.83 and HO-rbST125 = 10.36 ng/mL) and postpartum (log 10 back-transformed concentrations of GH: HO-control = 10.45 and HO-rbST125 = 18.47 ng/mL) periods. Similarly, IGF-1 concentrations were higher during the prepartum (HO-control = 115.1 ± 4.9, HO-rbST125 = 137.7 ± 4.7, JS-control = 120.2 ± 8.3, JS-rbST125 = 167.1 ± 8.1 ng/mL) and postpartum (HO-control = 61.3 ± 4.0, HO-rbST125 = 75.2 ± 3.8, JS-control = 35.5 ± 6.9, JS-rbST125 = 54.6 ± 6.9 ng/mL) periods for rbST-treated cows. During the prepartum period, BCS was not affected by treatment, but during the postpartum period, BCS was reduced for rbST-treated cows (HO-control = 3.00 ± 0.03, HO-rbST125 = 2.90 ± 0.03, JS-control = 2.64 ± 0.02, JS-rbST125 = 2.61 ± 0.02). Cows from the rbST125 treatment tended to have lower incidence of retained fetal membranes (HO-control = 14.3, HO-rbST125 = 6.1, JS-control = 1.5, JS-rbST125 = 1.2%) and had reduced incidence

  8. Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis.

    Science.gov (United States)

    Lei, Zhixin; Fu, Shulin; Yang, Bing; Liu, Qianying; Ahmed, Saeed; Xu, Lei; Xiong, Jincheng; Cao, Jiyue; Qiu, Yinsheng

    2017-08-08

    Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves showed that JS32 had a higher growth rate but fewer bacteria than JS0135. The cell membranes of JS32 and a resistant clinical isolate (HB32) were observed to be smoother than those of JS0135. From the comparative gene expression profile 349 up- and 113 downregulated genes were observed, covering 37 GO and 63 KEGG pathways which are involved in biological processes (11), cellular components (17), molecular function (9), cellular processes (1), environmental information processing (4), genetic information processing (9) and metabolism (49) affected in JS32. In addition, the relative overexpression of genes of the metabolism pathway (HAPS_RS09315, HAPS_RS09320), ribosomes (HAPS_RS07815) and ABC transporters (HAPS_RS10945) was detected, particularly the metabolism pathway, and verified with RT-qPCR. Collectively, the gene expression profile in connection with tildipirosin resistance factors revealed unique and highly resistant determinants of H. parasuis to macrolides that warrant further attention due to the significant threat of bacterial resistance.

  9. Industrial irradiators and its radioprotection. 1. ed.; Irradiadores industriais e sua radioprotecao

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues Junior, Ary de Araujo

    2014-06-01

    The book contains 9 chapters and an appendix section related to: 1) A little bit of radiation physics and radiation protection. 2) Radiators. 3) Safety. 4) Maintenance. 5) Training. 6) Accidents. 7) Transport and load of radioactive material. 8) Final thinking about safety. 9) Issues specific tests of the Brazilian Nuclear Energy Commission - CNEN.

  10. The Sap Flow Dynamics and Response of Hedysarum scoparium to Environmental Factors in Semiarid Northwestern China.

    Directory of Open Access Journals (Sweden)

    Jifeng Deng

    Full Text Available Hedysarum scoparium is an important, fast-growing and drought-resistant shrub that has been extensively used for grassland restoration and preventing desertification in semiarid regions of northwestern China. The primary objective of this study was to investigate the diurnal and seasonal variations in stem sap flow (Js and its relation to environmental factors. The stem heat balance method was applied to plants that were approximately 17 years old (with diameters of 25, 16, 13, and 9 mm at ground level and heights of 3.1, 1.8, 1.7 and 1.4 m and growing under natural conditions. The vertical soil temperature profile (ST, soil surface heat flux (SoilG, volumetric soil moisture content (SWC and meteorological variables such as solar radiation (Rn, air temperature (Ta, vapour pressure deficit (VPD, wind speed (Ws relative humidity (RH and precipitation (P were simultaneously measured at a meteorological station on site. Results indicated that Js varied regularly during the diurnal and seasonal term. The nocturnal Js was substantial, with a seasonal variation similar to the patterns of daytime Js. The magnitude of Js changed considerably between sunny and rainy days. Redundancy (RDA and Kendall's tau analysis suggested that daily Js in large plants was more sensitive to environmental factors, and the variation in daily Js during the growing season could be described by a multiple linear regression against environmental variables including Ta, VPD, Ws, RH, ST, and SoilG. While the nocturnal Js in smaller plants was more sensitive to meteorological factors. Ta, VPD, and Ws were significantly correlated with nighttime Js. The hourly nighttime sap flow rate of H. scoparium corresponded closely to Ta and VPD following a non-linear pattern. The results of this study can be used to estimate the transpiration of H. scoparium.

  11. Sencha Architect app development

    CERN Document Server

    Groner, Loiane

    2013-01-01

    A standard tutorial-based approach for using Sencha Architect to develop applications in Ext JS and Sencha Touch.Sencha Architect App Development is for Ext JS and Sencha Touch developers that are looking to improve their productivity by using Sencha Architect for app development. Basic knowledge of Ext JS and Sencha Touch is required.

  12. Definitive Radiotherapy of Non-Small Cell Lung Cancer

    International Nuclear Information System (INIS)

    Lee, Jong Young; Park, Kyung Ran

    1995-01-01

    Purpose : The effect of dose escalation of up to 6500 cGy on local control and survival was investigated in locally advanced non-small cell lung cancer. Materials and Methods : Ninety eight patients with biopsy-proven unresectable non-small cell lung cancer without distant metastases or medically inoperable patients with lower-stage were treated with definitive radiotherapy alone. Group A were treated by thoracic irradiation, 6000 cGy or less in total tumor dose with daily fractions of 180 to 200 cGy: and group B was treated with 6500 cGy of same daily fractions. Results : The actuarial overall survival rate for the entire group was 54% at 1 year, 26.6% at 2 years and 16.4% at 3 years with a median survival time of 13 months. Statistically significant prognostic factors that affect survival rate were stage and N-stage. However, no improvement in local control and survival has been seen with higher dose radiotherapy(group B). Conclusion : Dose escalation of up to 6500 cGy was no effect on local control and survival rate. To increase the survival rate of non-small cell lung cancer hyperfractionated radiotherapy or concurrent chemoradiotherapy should be considered

  13. Northern star J.S. Plaskett

    CERN Document Server

    Broughton, R Peter

    2018-01-01

    Northern Star explores Plaskett's unorthodox and fascinating life from his rural roots near Woodstock through his days as a technician at the University of Toronto to his initiation in astronomy at the Dominion Observatory in Ottawa.

  14. Optimising JS visualisation for notebooks

    CERN Document Server

    She, Harry

    2017-01-01

    In a large number of notebooks that are created and used by users of CERN, many important components are those related to graphical visualization. These include, but are not limited to graphs and histograms of data and events from physical detectors. However, the information used to display the ROOT graphical primitives is too comprehensive and hence cause the physical space requirements of the notebooks to grow drastically as the number of graphs and plots increases. Analysis has been performed to trim out redundant information from the notebooks, as well as providing insight into browsing ROOT objects within a notebook.

  15. IMORO, ZA; COBBINA, JS DOI

    African Journals Online (AJOL)

    ADOWIE PERE

    2018-03-21

    Mar 21, 2018 ... Synthesis of Insecticides from Selected Plant Materials ... Penny royal ('D') and Garlic extract + Orange oil + Penny royal ('E'). Mosquitoes (Culex spp. ... in compounds and about 1% at undisclosed locations ... Protection Agency before they are marketed ... oils were stored in sterilized, inert plastic bottles.

  16. IMORO, ZA; COBBINA, JS DOI

    African Journals Online (AJOL)

    ADOWIE PERE

    2018-03-21

    Mar 21, 2018 ... This is an open access article distributed under the. Creative ... several interventions have been put in place to arrest ... products but the challenge is, these interventions are ... importation, marketing and use of chemicals and.

  17. Quality of Life of Severe Sepsis Survivors After Hospital Discharge Calidad de vida de sobrevivientes de sepsis grave después del alta hospitalar Qualidade de vida de sobreviventes de sepse grave após alta hospitalar

    Directory of Open Access Journals (Sweden)

    Ligia Marcia Contrin

    2013-06-01

    Full Text Available AIMS: to evaluate the quality of life in severe sepsis survivors, using specific QoL questionnaires: the EuroQol-5 Dimensions and the Visual Analogue Scale (EQ-VAS. METHOD: This case-control study was performed in patients discharged from a teaching hospital after being admitted to the ICU with severe sepsis. Medical records from 349 patients were retrieved from the hospital sepsis registry. Each patient with sepsis was considered as a case. Patients who were admitted immediately after the sepsis episode were considered as controls, provided that they did not have sepsis and survived the ICU admission. This specific study population included 100 patients. RESULTS: The sepsis group showed higher mortality at 1 year compared with critically ill patients. However, the control group showed no sepsis. Older patients (>60 years in the sepsis group had a significantly higher prevalence of problems. There were no differences in EQ-VAS between respondents from both groups. CONCLUSIONS: After discharge from ICU, sepsis survivors of sepsis had a higher mortality rate than critically ill patients without sepsis. Older patients with sepsis had more moderate and severe problems in all five quality of life dimensions evaluated. OBJETIVO: Evaluación de la calidad de vida de los sobrevivientes de sepsis grave con los instrumentos EuroQol-5D y la Escala Analógica Visual (EQ-VAS. MÉTODO: Estudio caso-control anidado en pacientes que recibieron alta de la unidad de cuidados intensivos (UCI de un hospital de enseñanza después de la admisión con sepsis grave. La selección fue realizada a partir del registro de sepsis conteniendo 349 pacientes y cada paciente con sepsis fue considerado como un caso y el que fue hospitalizado inmediatamente después fue seleccionado como control, desde que no tuviera sepsis y hubiera sobrevivido a la hospitalización en la UCI y la sepsis, totalizando 100 sujetos. RESULTADOS: El grupo de sepsis mostró una mayor mortalidad a 1 a

  18. Dispareunia en mujeres después del parto: estudio de casos y controles en un hospital de Acapulco, México Women’s dyspareunia after childbirth: a case study in a hospital in Acapulco, Mexico

    Directory of Open Access Journals (Sweden)

    Elvia Solana-Arellano

    2008-01-01

    Full Text Available OBJETIVO: Identificar los factores asociados con la dispareunia entre 60 y 180 días después del parto en mujeres con antecedentes de uno o dos partos. MÉTODOS: Estudio de casos y controles, pareados por la edad y la paridad en 304 mujeres que acudieron al servicio de planificación familiar de un hospital de Acapulco, Guerrero, México, entre los 60 y 180 días después del parto. Se aplicó un cuestionario con preguntas sobre su situación socioeconómica (edad, escolaridad propia y de su pareja, estado civil, situación laboral, de seguridad social y de tenencia de su casa y sus antecedentes obstétricos (características del parto, paridad, lugar de atención, desgarros, episiotomía y complicaciones y ginecológicos (sensación de estrechez del introito, presencia de cicatriz queloide de la episiorrafia, síntomas de vaginitis, resequedad vaginal, métodos anticonceptivos empleados y tipo y duración de la lactancia. Se consideraron como casos a las mujeres que refirieron dolor, ardor o sangrado al tener relaciones sexuales con penetración vaginal después del parto. Se aplicó un modelo de regresión logística no condicionada y se calcularon las razones de posibilidades (odds ratios, OR y los intervalos de confianza de 95% (IC95%. RESULTADOS: De 368 mujeres que habían reiniciado relaciones sexuales, 152 (41,3% refirieron dispareunia. Los factores asociados con dispareunia fueron haber tenido infección con o sin dehiscencia de la episiorrafia (OR = 34,09; IC95%: 10,59 a 109,78, presentar síntomas de vaginitis (OR = 7,43; IC95%: 3,68 a 14,99, tener sensación de estrechez del introito vaginal (OR = 6,38; IC95%: 2,92 a 13,94 y practicar la lactancia exclusiva (OR = 4,86; IC95%: 2,44 a 9,69. CONCLUSIONES: La dispareunia estuvo relacionada con las complicaciones de la episiotomía y sus posibles secuelas, como la infección, la dehiscencia de la episiorrafia y la estrechez del introito vaginal. Se debe realizar una mejor vigilancia de la

  19. Después de los 90: agenda de cuestiones educativas After the 90's: an agenda on educational matters

    Directory of Open Access Journals (Sweden)

    Guillermina Tiramonti

    2003-01-01

    Full Text Available El art��culo propone una agenda de "cuestiones educativas" orientada a la reconstitución del lazo entre educación y democracia después de las reformas implementadas en los años 90. Construye previamente un estado de situación caracterizado por la presencia de tres procesos: a. un proceso de des-institucionalización escolar que se expresa tanto en la dificultad de la escuela para sostener un marco normativo sancionado socialmente, como en la crisis de identidad por la que atraviesan las instituciones; b. un proceso de fragmentación del sistema educativo que se diferencia de la tradicional segmentación de los sistemas; c. el agotamiento del instrumental teórico-conceptual con el que tradicionalmente nos hemos propuesto organizar y dar sentido a los fenómenos de la realidad. En este marco el artículo propone: 1. discutir los limites de la modernidad educativa en países periféricos como el nuestro y, en este marco, los de la pedagogía moderna para superar las problemáticas de discriminación y exclusión educativa; 2. rediscutir el concepto de ciudadanía y el papel de la escuela en la formación ciudadana; 3. repensar y discutir el papel del conocimiento y la investigación en la modificación de las practicas políticas y pedagógicas.This article proposes an agenda on "educational matters" which is meant for binding afair education to democracy after the reforms carried out in the 90's. First it describes the current state which is characterized by three processes: a. a school deinstitutionalization process which is expressed both in terms of the difficulty to keep a socially-sanctioned normative framework, and the identity crisis the institutions currently go through; b. a fragmentation process of the educational system which is different from the traditional segmentation of the systems; c. the wearing out of the theoretical and conceptual instruments on which we have been traditionally supposed to rely for organizing and

  20. The JOSHUA (J80) system programmer`s manual

    Energy Technology Data Exchange (ETDEWEB)

    Smetana, A.O.; McCort, J.T.; Westmoreland, B.W.

    1993-08-01

    The JOSHUA system routines (JS routines) can be used to manage a JOSHUA data base and execute JOSHUA modules on VAX/VMS and IBM/MVS computer systems. This manual provides instructions for using the JS routines and information about the internal data structures and logic used by the routines. It is intended for use primarily by JOSHUA systems programmers, however, advanced applications programmers may also find it useful. The JS routines are, as far as possible, written in ANSI FORTRAN 77 so that they are easily maintainable and easily portable to different computer systems. Nevertheless, the JOSHUA system provides features that are not available in ANSI FORTRAN 77, notably dynamic module execution and a data base of named, variable length, unformatted records, so some parts of the routines are coded in nonstandard FORTRAN or assembler (as a last resort). In most cases, the nonstandard sections of code are different for each computer system. To make it easy for programmers using the JS routines to avoid naming conflicts, the JS routines and common block all have six character names that begin with the characters {open_quotes}JS.{close_quotes} Before using this manual, one should be familiar with the JOSHUA system as described in {open_quotes}The JOSHUA Users` Manual,{close_quotes} ANSI FORTRAN 77, and at least one of the computer systems for which the JS routines have been implemented.

  1. Mensuração e características de dor após cesárea e sua relação com limitação de atividades Medida y características del dolor después de una cesárea y su relación con la limitación de actividades Measurement and characteristics of post-cesarean section pain and the relationship to limitation of physical activities

    Directory of Open Access Journals (Sweden)

    Lígia de Sousa

    2009-12-01

    Full Text Available Objetivo: Mensurar ecaracterizar a dor após cesárea e verificar sua relação com a limitação de atividades. Métodos: pesquisa descritiva com 60 puérperas após cesárea. Para avaliação da dor foram usadas a Escala Numérica e o Questionário de Dor McGill. As limitações de atividades foram avaliadas por instrumento elaborado pelas pesquisadoras. Resultados: a dor após a cesárea apresenta maiores escores no movimento de sentar e levantar. A dor é caracterizada como "incômoda", "que prende" e "que repuxa". Todas as participantes relataram que a dor limitava o movimento de sentar e levantar. Conclusão: foi possível observar que a dor após a cesárea é caracterizada como moderada. A dor promove limitação principalmente nas atividades de sentar e levantar e caminhar.Objetivo: Medir y caracterizar el dolor después de una cesárea y verificar su relación con la limitación de actividades cotidianas. Métodos: Investigación descriptiva con 60 puérperas después de una cesárea. Para evaluar el dolor fueron usadas la Escala Numérica y el Cuestionario del Dolor McGill. Las limitaciones de actividades fueron evaluadas por un instrumento elaborado por las investigadoras. Resultados: El dolor después de la cesárea presenta mayores puntajes en los movimientos de sentarse y levantarse. El dolor es caracterizado como "incomodo", "que sujeta" y "que se estira". Todas las participantes relataron que el dolor limitaba los movimientos de sentarse y levantarse. Conclusión: Fueposible observar que el dolor después de la cesárea es caracterizado como moderado. El dolor promueve limitaciones principalmente en las actividades de sentarse, levantarse y caminar.Objectives: To measure and characterize post cesarean section pain and to verify its relationship with limitations of physical activities. Methods: Descriptive study with 60 women in the post-operative period of cesarean section. Pain was measured with both the Numeric Scale and the

  2. [Investigation on sleep status of college and high school students].

    Science.gov (United States)

    Chen, Wei; Shen, Yue-di; Chen, Rong; Ding, Guo-xian

    2005-01-01

    To investigate the sleep status of college and high schools students. Pittsburgh sleep quality index (PSQI) and self-manufactured questionnaires about siesta habits were used as tools. Three groups of students from medical college (MC), senior high school (SS) and junior high school (JS) were surveyed. In the group MC, SS and JS, the occurrence rates of sleep disorders were 27%, 62% and 54%, respectively, and in which the appearance rates of insomnia were 17%, 19% and 19%, longing for sleep were 10%, 43% and 35% respectively. And there were no significant difference between schoolboy and schoolgirl. The occurrence rates of slack breathing were different (5/155, 1/154) significantly between group SS and JS. The distinct differences also were found in group JS and MC, in which students felt hot (10/155, 1/122) and in all the three groups, in which students felt sleepy (55/155, 62/154, 13/122) whereas the difference of sleepy between group SS and JS was comparatively distinct (55/155, 62/154). Significant differences were also found between group JS and SS, MC in average sleep time of (7.65 +/- 0.87) hours, (7.16 +/- 0.83) hours, and (7.10 +/- 0.57) hours. The time of falling asleep (median 15 min, 10 min, 20 min) and siesta habit (8/155, 19/154, 75/122) among group MC and SS, JS were different respectively and markedly, whereas siesta habit differences between group SS and JS were comparatively distinct (8/155, 19/154). Students in high school showed higher rate of longing for sleep, and this implicated they fall short of sleep time greatly and siesta could improve their sleepy signs.

  3. Surface magnetization of the Ising ferromagnet in semi-infinite cubic lattice: renormalization group approach

    International Nuclear Information System (INIS)

    Chame, A.M.N.; Tsallis, C.

    1988-01-01

    The behaviour of the spontaneous surface and bulk magnetizations as function of the temperature for the Ising ferromagnet in a semi-infinitre cubic lattice for various ratios JS/JB (JS and JB are the surface and bulk coupling constants, respectively), is studied. The extraordinary transition where the surface maintains its magnetization as the bulk disorders, was study, in particular; a discontinuity on the first derivative of the surface magnetization at the bulk transition temperature was found. The criticality of the system (universality classes, critical exponents and amplitudes) is discussed. An unexpected slight lack of monotonicity of the surface magnetization as a function of JS/JB for JS/JB [pt

  4. The CERN's year; L'annee du CERN

    Energy Technology Data Exchange (ETDEWEB)

    Chadli, M. [Universite de Picardie Jules Verne, CREA, 80 - Amiens (France); Coppier, H. [Ecole Superieure d' Ingenieurs en Electrotechnique et Electronique d' Amiens - ESIEE Amiens, 80 - Amiens (France); Pezzeti, M. [Conseil Europeen pour la Recherche Nucleaire (CERN), Geneve (Switzerland)

    2007-12-15

    CERN, the European organization for nuclear research, has just celebrated its fifty years of existence. Its first goal was to counterbalance the migration of physics scientists towards the USA by the creation of a physics laboratory gathering scientists from the different European countries. Today, the CERN's mission has changed and has overcome all the expectations of its founders. In 2008, it will become, with the LHC (Large Hadron Collider), the biggest particle accelerator in the world. The CERN employs about 3000 physicists, engineers, technicians and workers. There is also 6500 people from 80 different countries who use the CERN's facilities during the year. The CERN is controlled by 20 European member states and 6 observer countries, and 20 non-member countries participate to the programs in progress. The CERN's power comes from its international and cosmopolitan spirit. The whole most famous physicists of the world can work together for the progress of science and for a better understanding of matter, of its interactions and of our universe. Two Nobel prices of physics come from the CERN: C. Rubbia and S. Van der Meer in 1983 for the discovery of W{sup +}, W{sup -} and Z{sub 0} bosons, and G. Charpak for the development of particle detectors. One can foresee that the LHC will allow new scientific achievements, like for instance, during experiments for the quest of the famous Higgs boson. It is important also to mention that the CERN has been at the origin of several technological innovations in all technical and engineering domains in the framework of its fundamental physics researches. (J.S.)

  5. Radiation induced mutagenesis in soybean (Glycine Max L. Merrill)

    International Nuclear Information System (INIS)

    Wakode, M.M.; Nandanwar, R.S.; Patil, G.P.

    2000-01-01

    The mutagenic effects of gamma rays (10, 20 and 30 kR) on some biological parameter in M1 generation and frequency and spectrum of chlorophyll and morphological mutations in five cultivars of soybean viz. JS-8021, JS-335, JS- 7105, Monetta and PKV -1 have been studied. A dose dependant decrease was noticed in most of the characters like root length, shoot length, germination, plant height, plant survival and pollen sterility. While seedling height, number of seeds per pod and number of branches per plant were not affected significantly. The highest frequency and spectrum of chlorophyll and morphological mutations was noticed in variety JS-8021 in which 20 different gene loci for various characters were mutated. However variety JS- 7105 showed less radio sensitive response for different traits in which only 12 different loci were mutated. While JS-335, monetta and PKV-I showed moderate response to frequency and spectrum of various mutations. These varieties showed differential response to radio sensitivity, some useful mutations included, high yielding mutant in 20 kR, non shattering mutant in 30 kR and vine type mutant in 10 kR in variety monetta. Extra early type, erect and high branched type mutant were recorded with high frequency in 10 and 20 kR respectively in variety JS-8021. In general, 20 kR dose was found more effective in all the varieties studied. (author)

  6. Evaluación de la retinopatía diabética proliferativa después del tratamiento con láser Evaluation of proliferative diabetic retinopathy after laser treatment

    Directory of Open Access Journals (Sweden)

    Juana Elvira Maciques Rodríguez

    2007-12-01

    Full Text Available La fotocoagulación láser (panfotocoagulación es indicación absoluta en la retinopatía diabética proliferativa (RDP sin y con características de alto riesgo de pérdida visual severa. Con el objetivo de evaluar este tratamiento en la RDP, se realizó este estudio desde enero de 2004 a diciembre de 2005 en el Centro de Atención al Diabético del Instituto de Endocrinología. Se estudiaron 120 pacientes con RDP, que se fotocoagularon. Las variables estudiadas fueron: edad, sexo, tiempo de evolución de la diabetes y presencia de hipertensión arterial y/o neuropatía. Se realizó examen oftalmológico y se comparó la agudeza visual y el estadio de la retinopatía antes y después del tratamiento. Para el análisis estadístico se utilizó la prueba de chi cuadrado. La forma avanzada de RDP se encontró en pacientes con más de 20 años de evolución de la enfermedad. Después del tratamiento en las mujeres predominó la RDP sin características de alto riesgo (CAR (38,1 % y en los hombres la RDP con CAR (38,9 %; 11 pacientes pasaron a la forma de retinopatía diabética (RD no proliferativa. La hipertensión arterial y la nefropatía diabética predominaron en la RDP con CAR y avanzada. Se concluye que la forma más grave de RD se asoció a mayor tiempo de evolución. La hipertensión arterial y la nefropatía son factores de riesgo asociados a las formas más severas de RD. La fotocoagulación no mejoró la visión de forma significativa, pero sí detiene la progresión de la retinopatía, e incluso, es capaz de modificar la severidad pasando a formas no proliferativas.Laser photocoagulation (panphotocoagulation is an absolute indication in the proliferative diabetic retinopathy (PDR without or with characteristics of high risk for severe visual loss. This study was undertaken at the Diabetic Care Center of the Institute of Endocrinology from January 2004 to December 2005 in order to evaluate this treatment in PDR. 120 patients with PDR

  7. Correlated colour temperature of morning light influences alertness and body temperature.

    Science.gov (United States)

    Te Kulve, Marije; Schlangen, Luc; Schellen, Lisje; Souman, Jan L; van Marken Lichtenbelt, Wouter

    2018-03-01

    Though several studies have reported human alertness to be affected by the intensity and spectral composition of ambient light, the mechanism behind this effect is still largely unclear, especially for daytime exposure. Alerting effects of nocturnal light exposure are correlated with melatonin suppression, but melatonin levels are generally low during the day. The aim of this study was to explore the alerting effect of light in the morning for different correlated colour temperature (CCT) values, as well as its interaction with ambient temperature. Body temperature and perceived comfort were included in the study as possible mediating factors. In a randomized crossover design, 16 healthy females participated in two sessions, once under 2700K and once under 6500K light (both 55lx). Each session consisted of a baseline, a cool, a neutral and a warm thermal environment. Alertness as measured in a reaction time task was lower for the 6500K exposure, while subjective sleepiness was not affected by CCT. Also, core body temperature was higher under 6500K. Skin temperature parameters and perceived comfort were positively correlated with subjective sleepiness. Reaction time correlated with heat loss, but this association did not explain why the reaction time was improved for 2700K. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Plexopatia lombar após histerectomia abdominal: relato de caso Plexopatía lumbar después de la histerectomía abdominal: relato de caso Lumbar plexopathy after abdominal hysterectomy: case report

    Directory of Open Access Journals (Sweden)

    Elizabeth Vaz da Silva

    2006-12-01

    íodo postoperatorio muchas veces se atribuyen al acto anestésico, aunque puedan también decorrer del acto quirúrgico. El objetivo de este relato fue presentar el caso de una paciente sometida a la intervención quirúrgica pélvica que evolucionó con un cuadro de plexopatía lumbar y discutir las posibles causas. RELATO DEL CASO: Paciente del sexo femenino, 38 años, 58 kg, 1,63 m de altura, estado físico ASA I, internada para tratamiento de leiomiomatosis uterina, con indicación de histerectomía total abdominal. La monitorización inicial incluyó oxímetro de pulso, presión arterial no invasiva, electrocardioscopio y diuresis. Después de la punción venosa en el miembro superior izquierdo con catéter 18G, fueron administrados, por vía venosa, cefazolina (2 g, dipirona (2 g, dexametasona (10 mg y metoclopramida (10 mg. La anestesia peridural fue realizada con aguja Tuohy 16G, en el espacio L3-L4, en la línea mediana con la paciente en decúbito lateral izquierdo. Fueron administrados 15 mL de ropivacaína a 0,75% y 2 mg de morfina, a continuación posicionado catéter para analgesia postoperatoria. La intervención quirúrgica no tuvo intercurrencia, manteniendo a la paciente estable bajo el punto de vista cardiovascular. En la visita posanestésica, 8 horas después del procedimiento, la paciente no deambulaba y presentaba monoparesia en el miembro inferior izquierdo. Después de las investigaciones clínicas y radiológicas fue descartada la hipótesis diagnóstica de síndrome radicular. Al no haber regresión del cuadro, 30 días después fue realizada una electroneuromiografía que quedo compatible con plexopatía lumbar de posible origen traumática. CONCLUSIONES: El anestesiólogo debe estar atento a las complicaciones neurológicas que puedan surgir en el postoperatorio, participando de la elucidación de las causas, del tratamiento y de su evolución.BACKGROUND AND OBJECTIVES: Very often, neurological injuries diagnosed postoperatively are attributed to the

  9. Experiência da gravidez após os 35 anos de mulheres com baixa renda Experiencia del embarazo después de los 35 años de mujeres con ingreso bajo Experience of pregnancy beyond 35 years of age of women with low income

    Directory of Open Access Journals (Sweden)

    Cristina Maria Garcia de Lima Parada

    2009-06-01

    Full Text Available Objetivou-se apreender as representações sociais sobre gravidez após os 35 anos a partir de mulheres com baixa renda que vivenciaram essa experiência. A abordagem qualitativa foi empregada com base na Teoria das Representações Sociais. Foram realizadas entrevistas semiestruturadas com 25 gestantes usuárias de um serviço público de referência do interior paulista. Os dados foram sistematizados pela técnica do Discurso do Sujeito Coletivo. Verificou-se que a opção pela gravidez tardia se atrela ao desejo da mulher de consolidar suas relações em novas uniões conjugais, à estabilidade financeira e à maturidade do casal. As mulheres representam esta experiência como positiva, se houver planejamento prévio, envolvimento do companheiro e se for bem aceita pela família, após sua constatação. Sem a satisfação destas condições, as representações revestem-se de sentimentos negativos ligados a dor, sofrimento e morte. As conclusões deste estudo enfatizam a importância de os serviços públicos de saúde considerarem estes aspectos.El objetivo fue aprehender las representaciones sociales sobre el embarazo después de los 35 años de mujeres de bajo ingreso que han vivido esa experiencia. Se empleó el enfoque cualitativo y para el análisis de los datos, se utilizó el Discurso del Sujeto Colectivo. Fueron realizadas entrevistas semiestructuradas con 25 gestantes usuarias de un servicio público de referencia del interior de São Paulo. En los tres temas tratados: opción concientizada para la maternidad, conflictos y disgustos en el embarazo y la participación activa de la pareja, se puede verificar que la gestación después de los 35 años está fuertemente relacionada con el deseo de la mujer de consolidar sus relaciones en nuevas uniones conyugales, con la estabilidad financiera y con la madurez de la pareja. También, fue posible aprehender que las mujeres representan el embarazo tardío como experiencia positiva, si

  10. Methodological concerns for determining power output in the jump squat.

    Science.gov (United States)

    Cormie, Prue; Deane, Russell; McBride, Jeffrey M

    2007-05-01

    The purpose of this study was to investigate the validity of power measurement techniques during the jump squat (JS) utilizing various combinations of a force plate and linear position transducer (LPT) devices. Nine men with at least 6 months of prior resistance training experience participated in this acute investigation. One repetition maximums (1RM) in the squat were determined, followed by JS testing under 2 loading conditions (30% of 1RM [JS30] and 90% of 1RM [JS90]). Three different techniques were used simultaneously in data collection: (a) 1 linear position transducer (1-LPT); (b) 1 linear position transducer and a force plate (1-LPT + FP); and (c) 2 linear position transducers and a force place (2-LPT + FP). Vertical velocity-, force-, and power-time curves were calculated for each lift using these methodologies and were compared. Peak force and peak power were overestimated by 1-LPT in both JS30 and JS90 compared with 2-LPT + FP and 1-LPT + FP (p squat varies according to the measurement technique utilized. The 1-LPT methodology is not a valid means of determining power output in the jump squat. Furthermore, the 1-LPT + FP method may not accurately represent power output in free weight movements that involve a significant amount of horizontal motion.

  11. Multi-control modes for a master-slave manipulator with different configurations and its maneuverability

    International Nuclear Information System (INIS)

    Matsuhira, Nobuto; Asakura, Makoto; Bamba, Hiroyuki

    1995-01-01

    The new master-slave control method is proposed on multi-control modes for a master-slave manipulator with different configurations. A virtual internal model following control is applied to position symmetrical bilateral control. In our method, a master-slave control mode (MS-mode), a joystick control mode (JS-mode), a master arm offset mode (OM-mode), and a servo hold mode (LK-mode) are able to be realized by operating the desired output values of the virtual internal models in a common control algorithm. There is compliant characteristic between the master and slave models. In the result of evaluation experiments between the MS-mode and the JS-mode, although the MS-mode is superior to the JS-mode in manipulating a fine task, our JS-mode is found to be useful to carry out such a task compared with a conventional JS-mode which only directs the rates for the slave arm. In the JS-mode, the slave arm moves to the position where the reaction force of the slave arm and the operating force of the master arm are balanced. Thus, it is possible either to control an overload for an object and to control the contact force. The validity of the proposed method is verified. (author)

  12. The Mediating Role of Job Stress on The Effect of Mobbing on Burnout: An Analysis of Social Security Organization Employees in The District of Ankara

    Directory of Open Access Journals (Sweden)

    Yücel Erol

    2015-06-01

    Full Text Available In this study, due to the influence of Mobbing (MO on Burnout (BU, the mediating role of Job Stress (JS on employees is examined. Hence, 826 employees of public and private institutions in Ankara were included in the sample. The data obtained by a questionnaire that prepared by Leymann (1996’s MO scale, and Maslach (1981's BU scale and Haynes (1996's JS scale. Data was evaluated by using One-Way ANOVA, correlation, regression, and multiple regression SPSS. As can be seen from the results of research, applied and perceived MO has a significant impact on employees' JS’s levels and becomes effective in the creation of JS. On the other hand, BU syndrome were seen as a consequence of the resulting JS. These conditions affect each other and existence of one within the organizational structure, results emergence of the other two. Therefore, management of organization, all levels of managers, and employees as individuals should be aware of these psychological states and conduct studies aimed for its prevention.In this research, meaningful relationships have been identified in the mediating role of JS at the impact of MO on BU. On the other hand in terms of demographic variables, significant variations were found in the levels of MO, BU, and JS

  13. Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

    Science.gov (United States)

    Oksaharju, Anna; Kooistra, Teake; Kleemann, Robert; van Duyvenvoorde, Wim; Miettinen, Minja; Lappalainen, Jani; Lindstedt, Ken A; Kovanen, Petri T; Korpela, Riitta; Kekkonen, Riina A

    2013-07-14

    A high-fat diet disturbs the composition and function of the gut microbiota and generates local gut-associated and also systemic responses. Intestinal mast cells, for their part, secrete mediators which play a role in the orchestration of physiological and immunological functions of the intestine. Probiotic bacteria, again, help to maintain the homeostasis of the gut microbiota by protecting the gut epithelium and regulating the local immune system. In the present study, we explored the effects of two probiotic bacteria, Lactobacillus rhamnosus GG (GG) and Propionibacterium freudenreichii spp. shermanii JS (PJS), on high fat-fed ApoE*3Leiden mice by estimating the mast cell numbers and the immunoreactivity of TNF-α and IL-10 in the intestine, as well as plasma levels of several markers of inflammation and parameters of lipid metabolism. We found that mice that received GG and PJS exhibited significantly lower numbers of intestinal mast cells compared with control mice. PJS lowered intestinal immunoreactivity of TNF-α, while GG increased intestinal IL-10. PJS was also observed to lower the plasma levels of markers of inflammation including vascular cell adhesion molecule 1, and also the amount of gonadal adipose tissue. GG lowered alanine aminotransferase, a marker of hepatocellular activation. Collectively, these data demonstrate that probiotic GG and PJS tend to down-regulate both intestinal and systemic pro-inflammatory changes induced by a high-fat diet in this humanised mouse model.

  14. 77 FR 10761 - Agency Information Collection Activities: Screening Requirements for Carriers

    Science.gov (United States)

    2012-02-23

    ... the collection of information (a total capital/ startup costs and operations and maintenance costs... per Respondent: 100 hours. Estimated Total Annual Burden Hours: 6,500. Dated: February 17, 2012...

  15. Reafirmación de la vitalidad de los rituales a las montañas y a la lluvia después del paso de un huracán en el Altiplano Mam de Guatemala

    Directory of Open Access Journals (Sweden)

    Julie Hermesse

    2014-09-01

    Full Text Available Las condiciones meteorológicas de Mesoamérica se caracterizan por la alternancia sucesiva de temporadas secas y temporadas de lluvias. En las primeras, los agricultores deben enfrentarse a una escasez de agua, mientras que en las segundas, deben prepararse al peligro del exceso de lluvias, o incluso a tormentas tropicales y a huracanes. En el Altiplano Mam de Guatemala, región montañosa fundamentalmente agrícola, los cambios en los patrones de lluvias son las principales amenazas para los cultivos. No es pues extraño que, desde tiempos remotos, las poblaciones mam pidan a los ajq'ij (sacerdote maya que asuman el papel de intermediarios ante las «figuras invisibles» de la lluvia y de las montañas. Un trabajo etnográfico de larga duración, empezado en Guatemala después del paso del huracán Stan (2005, permitió observar la vivacidad y la continuidad de rituales tradicionales que tienen por objetivo controlar la lluvia y proteger las montañas. Esto, a pesar de la emergencia de un contexto de cambio de los sistemas simbólicos ante las conversiones masivas al evangelismo.

  16. Zn I spectra in the 1300–6500 cm−1 range

    International Nuclear Information System (INIS)

    Civiš, S.; Ferus, M.; Chernov, V.E.; Zanozina, E.M.; Juha, L.

    2014-01-01

    We study spectra of a plasma created by the laser ablation of ZnS targets in a vacuum and report 47 (not observed previously) Zn I lines in the range of 1300–6400 cm −1 . From the recorded spectra we determine energies of 5g, 6g, 7f, 6h, 7h and 8h Zn I levels. We also calculate a large list of transition probabilities and oscillator strengths for Zn I in the observed spectral range. -- Highlights: • We report 47 new Zn I lines in the range of 1300–6400 cm −1 . • We determine energies of 5g, 6g, 7f, 6h, 7h and 8h states of Zn I. • Using quantum defect theory, we calculate a large list of transition probabilities

  17. Therapeutics for Rare and Neglected Diseases

    Data.gov (United States)

    Federal Laboratory Consortium — There are more than 6,500 identified rare and neglected diseases, yet only about 250 treatments are available for these conditions. The limited numbers of patients...

  18. 76 FR 80375 - Agency Information Collection Activities: Screening Requirements for Carriers

    Science.gov (United States)

    2011-12-23

    ... keepers from the collection of information (a total capital/startup costs and operations and maintenance... per Respondent: 100 hours. Estimated Total Annual Burden Hours: 6,500. Dated: December 19, 2011...

  19. On atmospheric-pressure non-equilibrium plasma jets and plasma bullets

    International Nuclear Information System (INIS)

    Lu, X; Laroussi, M; Puech, V

    2012-01-01

    Atmospheric-pressure non-equilibrium plasma jets (APNP-Js), which generate plasma in open space rather than in a confined discharge gap, have recently been a topic of great interest. In this paper, the development of APNP-Js will be reviewed. Firstly, the APNP-Js are grouped based on the type of gas used to ignite them and their characteristics are discussed in detail. Secondly, one of the most interesting phenomena of APNP-Js, the ‘plasma bullet’, is discussed and its behavior described. Thirdly, the very recent developments on the behavior of plasma jets when launched in a controlled environment and pressure are also introduced. This is followed by a discussion on the interaction between plasma jets. Finally, perspectives on APNP-J research are presented. (paper)

  20. La administración oral de glicerol después de la inseminación incrementa el porcentaje de concepción en vacas Holstein

    Directory of Open Access Journals (Sweden)

    Alvaro Ortega León

    2010-01-01

    Full Text Available Se probó si un incremento en las concentraciones de insulina, provocado por la administración oral de una sustancia glucogénica (glicerol durante los primeros días posinseminación, aumenta el porcentaje de concepción (PC en vacas Holstein. Se utilizaron 190 vacas de uno a tres servicios, con condición corporal de 2.5 a 3. Al momento de la inseminación (día cero, se distribuyeron al azar en dos grupos: el grupo glicerol (n=95 recibió 1 L de solución de glicerol y agua (90:10, v/v, la cual se repitió en los días 2, 4 y 6 posinseminación. El grupo testigo (n=95 recibió 1 L de agua por vía oral en el mismo esquema. El diagnóstico de gestación se realizó por palpación rectal en el día 45 posinseminación. El PC se comparó con una prueba de Ji-cuadrada. En seis animales de cada grupo se determinaron las concentraciones plasmáticas de insulina mediante radioinmunoanálisis antes de la toma de glicerol y en los siguientes 15, 30, 60, 90, 120 y 240 min y se compararon mediante análisis de varianza para mediciones repetidas. El PC fue mayor (P<0.05 en el grupo glicerol (47.4 que en el testigo (31.6. Después de la administración del glicerol se observó un incremento de las concentraciones de insulina (P<0.05. Se concluye que la administración de glicerol durante los primeros seis días posinseminación aumenta el porcentaje de concepción en vacas Holstein; probablemente el incremento de la insulina posterior a la toma del glicerol esté involucrado en dicho efecto.

  1. Jump Squat is More Related to Sprinting and Jumping Abilities than Olympic Push Press.

    Science.gov (United States)

    Loturco, I; Kobal, R; Maldonado, T; Piazzi, A F; Bottino, A; Kitamura, K; Abad, C C C; Pereira, L A; Nakamura, F Y

    2017-07-01

    The aim of this study was to test the relationships between jump squat (JS) and Olympic push press (OPP) power outputs and performance in sprint, squat jump (SJ), countermovement jump (CMJ) and change of direction (COD) speed tests in elite soccer players. 27 athletes performed a maximum power load test to determine their bar mean propulsive power (MPP) and bar mean propulsive velocity (MPV) in the JS and OPP exercises. Magnitude-based inference was used to compare the exercises. The MPV was almost certainly higher in the OPP than in the JS. The MPP relative to body mass (MPP REL) was possibly higher in the OPP. Only the JS MPP REL presented very large correlations with linear speed ( r> 0.7, for speed in 5, 10, 20 and 30 m) and vertical jumping abilities ( r> 0.8, for SJ and CMJ), and moderate correlation with COD speed ( r= 0.45). Although significant (except for COD), the associations between OPP outcomes and field-based measurements (speed, SJ and CMJ) were all moderate, ranging from 0.40 to 0.48. In a group composed of elite soccer players, the JS exercise is more associated with jumping and sprinting abilities than the OPP. Longitudinal studies are needed to confirm if these strong relationships imply superior training effects in favor of the JS exercise. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

    Directory of Open Access Journals (Sweden)

    Anna E. Maciag

    2013-01-01

    Full Text Available JS-K is a nitric oxide (NO-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metabolic actions of JS-K was undertaken to investigate mechanisms of its cytotoxicity. Consistent with model chemical reactions, the activating step in the metabolism of JS-K in the cell is the dearylation of the diazeniumdiolate by glutathione (GSH via a nucleophilic aromatic substitution reaction. The resulting product (CEP/NO anion spontaneously hydrolyzes, releasing two equivalents of NO. The GSH/GSSG redox couple is considered to be the major redox buffer of the cell, helping maintain a reducing environment under basal conditions. We have quantified the effects of JS-K on cellular GSH content, and show that JS-K markedly depletes GSH, due to JS-K's rapid uptake and cascading release of NO and reactive nitrogen species. The depletion of GSH results in alterations in the redox potential of the cellular environment, initiating MAPK stress signaling pathways, and inducing apoptosis. Microarray analysis confirmed signaling gene changes at the transcriptional level and revealed alteration in the expression of several genes crucial for maintenance of cellular redox homeostasis, as well as cell proliferation and survival, including MYC. Pre-treating cells with the known GSH precursor and nucleophilic reducing agent N-acetylcysteine prevented the signaling events that lead to apoptosis. These data indicate that multiplicative depletion of the reduced glutathione pool and deregulation of intracellular redox balance are important initial steps in the mechanism of JS-K's cytotoxic action.

  3. El Papel de la Agricultura Familiar para la Diversificación y Valorización de la Producción de Alimentos Después de la Revolución Verde en Brasil

    Directory of Open Access Journals (Sweden)

    Alexandrina Benjamin Estevão de Farias

    2016-10-01

    Full Text Available Ese artigo pretende hacer una análisis de la cuestión de la producción de alimentos, después la revolución verde, y la eficacia del derecho a la alimentación en el país. A partir de los años 60, la modernización del campo a mantenido el modelo de los latifundios y del monocultivo en el escenario agrícola brasileiro y excluyendo la agricultura familiar del acceso a las nuevas tecnologías. Con eso, hubo una alteración en el modelo productivo de alimentos, reduciendo la diversidad de productos y comprometiendo el desarrollo de la relación hombre-alimento- sociedad. Considerando que, el modo de producción de alimentos tiene ligación directa a la relación del hombre con su medio y con la cultura en la cual está inmerso. Así, la agricultura familiar consistiría en una manera de explotación capaz de adaptar y persistir en ambientes con el predominio de las prácticas de naturaleza capitalista, así como es capaz de si adaptar a las nuevas exigencias de la sociedad (efectividad del derecho a la alimentación, el desarrollo sostenible agrícola, el combate a la hambre y miseria y la preservación ambiental.

  4. Using the MEAN Stack to implement a RESTful service for an Internet of Things Application

    OpenAIRE

    Poulter, Andrew J.; Johnston, Steven; Cox, Simon

    2016-01-01

    This paper examines the components of the MEAN development stack (MongoDb, Express.js, Angular.js, & Node.js), and demonstrate their benefits and appropriateness to be used in implementing RESTful web-service APIs for Inter- net of Things (IoT) appliances. In particular, we show an end- to-end example of this stack and discuss in detail the various components required. The paper also describes an approach to establishing a secure mechanism for communicating with IoT devices, using pull-co...

  5. Job satisfaction and its relationship with organisational commitment: A Democratic Republic of Congo organisational perspective

    Directory of Open Access Journals (Sweden)

    Jeremy Mitonga-Monga

    2018-06-01

    Full Text Available Orientation: The modern workplace, which is characterised by increasing turbulence and debilitating uncertainty, has led to renewed focus on whether employees experience satisfaction and how they commit themselves to the organisation. Research purpose: The aim of this study was to measure the nature of the relationship between employees’ levels of job satisfaction (JS and organisational commitment (OC in a public railway organisation in the Democratic Republic of Congo (DRC. Motivation for the study: Although previous researchers have found evidence of the relationship between JS and OC in Western countries, there seems to be a paucity of research on the relationship between JS and OC in a developing country context such as that of the DRC. The results could make a valuable contribution to the current literature debate on these two constructs (JS and OC and possibly employees’ intention to stay in their present organisation. Research design, approach and method: A cross-sectional survey design was used employing the Job Satisfaction Questionnaire and the Organisational Commitment Scale. The sample (n = 839 comprised permanently employed staff. Correlations and regression analyses were conducted. The results indicated that employees’ JS related positively to their level of OC and that JS predicted OC. Practical and managerial implications: The results should also have interesting implications for top management and human resource practitioners. They could use this information to study how organisational psychological attachment is fostered in order to potentially master other organisational dynamics. The information could also be used to create positive working conditions with a view to reinforcing OC. JS manifested as a critical driver of OC, which could result in superior business performance. Management could use the results to create a working environment that actively fosters satisfaction and boosts employees’ level of

  6. Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China.

    Science.gov (United States)

    Li, Fan; Li, Yuxueyun; Feng, Yi; Hu, Jing; Ruan, Yuhua; Xing, Hui; Shao, Yiming

    2017-07-01

    Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five sequences are all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, grouped into four new discovered recombinant forms, which show several very similar but not identical recombinant breakpoints. The four recombinant forms are also identified to be a sort of family or related viruses, seems to be the results of different recombination events. The emergence of a serious new closely related CRF07_BC/CRF01_AE recombinant strain indicates the increasing complexity of sexual transmission of the HIV-1 epidemic in China.

  7. Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē.

    OpenAIRE

    Afoņičeva, Oksana

    2016-01-01

    Maģistra darba: “Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē” mērķis ir, izvērtējot pārdošanas veicināšanas ietekmi uz patērētāju uzvedību, lēmuma pieņemšanas procesu un uz patērētāju lojalitātes veidošanu, rast priekšlikumus pārdošanas veicināšanas iespējām pārtikas produktu zīmoliem. Darbs sastāv no četrām nodaļām- divām teorētiskajām, analītiskās un empīriskās. Pirmā izvirzītā hipotēze tiek apstiprināta, pama...

  8. 20 CFR 658.413 - Initial handling of complaints by the State or local office.

    Science.gov (United States)

    2010-04-01

    ... related, or if non-JS related, it alleges violations of employment related laws enforced by ESA or OSHA.... The JS official shall send a confirming letter to this effect to the complainant and shall give the...

  9. J~S 3 :F ~: () - - -I =S

    African Journals Online (AJOL)

    played a crucial role. France,. Italy, Portugal,. Greece, Germany and many others have been ruled by army officers. From 1914 to 1923 Spain underwent 43 successful and unsuccessful military coups. Eventhe two superpowers, both committed to strict control of their military because of fear of nuclear war, have suffered from ...

  10. Web app testing using Knockout.JS

    CERN Document Server

    Messora, Roberto

    2014-01-01

    If you are a JavaScript developer, beginner, or an expert who wants to improve quality standards in terms of solutions design and functional verification, this book is for you. Basic understanding of web development, HTML, and JavaScript is required.

  11. Data visualization with d3.js

    CERN Document Server

    Teller, Swizec

    2013-01-01

    This book is a mini tutorial with plenty of code examples and strategies to give you many options when building your own visualizations.This book is ideal for anyone interested in data visualization. Some rudimentary knowledge of JavaScript is required.

  12. Machining Data Handbook. 3rd Edition. Volume 2

    Science.gov (United States)

    1980-01-01

    HY230 50 ORC age 250 Grade 7 ASTM A538: Grades A, B. C I 8. TOOL STEELS , WROUGHT r~n 5 05.05 1-. Group I 00 t oBOT5 A2 H13 L6 P20 8000 125 Finish: (Max...max 50 R ~ Maraged 0 Rough 112 8. TOOL STEELS , WROUGH4T Rough0 60/2 Group I to40 to 0 P2 H13 L6 P20 6500 !00 Finish- A3 H14 L7 P21 50 R Annealed 0005max...Over .0002 max. 50 Rc Maraged - s- . .__.. _ GroupRough: 8. TOOL STEELS , WROUGHT 1 5000 75 o.00 1/3 to to A60MV A2 H13 L6 P20 6500 200 Finish: A3 H14

  13. Bibliographic study of photophysical and photochemical properties of laser dyes

    International Nuclear Information System (INIS)

    Doizi, D.

    1986-06-01

    Laser isotope separation of uranium requires high power and precise wave length. This report is a bibliographic and experimental study of the photophysical and photochemical properties of seven commercial laser dyes which have an emission wavelength in the range 5500-6500 A: Rhodamine 110 or 560, rhodamine 6G or 590, rhodamine B or 610, rhodamine 101 or 640, sulforhodamine B or kiton red 620, sulforhodamine 101 or 640 and DCM or LC 6500. Absorption and emission cross section values, fluorescence lifetimes and quantum yields in various solvents are indicated. For each dye, a non exhaustive list of laboratory experiments made with two types of pump sources: Nd YAG (532) and copper vapor laser is given. When it is known, the toxicity of the dyes is mentioned [fr

  14. NCBI nr-aa BLAST: CBRC-DSIM-04-0090 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DSIM-04-0090 ref|YP_922866.1| putative ABC antibiotics transporter [Nocardioid...es sp. JS614] gb|ABL81179.1| putative ABC antibiotics transporter [Nocardioides sp. JS614] YP_922866.1 0.003 31% ...

  15. [The mediating role of organizational citizenship behavior between organizational justice and organizational effectiveness in nursing organizations].

    Science.gov (United States)

    Park, Wall Yun; Yoon, Sook Hee

    2009-04-01

    This study was a secondary analysis to verify the mediating role of organizational citizenship behavior (OCB) between organizational justice (OJ) and organizational effectiveness (OE) in nursing organizations. The RN-BSNs and their colleagues in Seoul and Busan were subjects. The data was collected for 20 days between September 13 and October 2, 2004. Two hundred eighty three data sets were used for the final analysis. The fitness of models were tested using AMOS 5. The fitness of hypothetical model was moderate. Procedural Justice (PJ), Interaction Justice (IJ) and Distributive Justice (DJ) had direct effects on Job Satisfaction (JS), Organizational Commitment (OC) and Turnover Intention (TI) in OE, and indirect effects on JS, OC and TI mediated by OCB. The modified model improved with ideal fitness showed the causal relations among OE. In modified model, PJ, IJ and DJ had direct positive effects on OCB and JS and OC in OE, and indirect effects on JS and OC mediated by OCB. JS and OC in OE had a direct negative effect on TI. OCB mediated the relationship between OJ and OE, so the nursing managers should enhance OCB of the nurses in order to improve OE.

  16. Angular distribution in proton-hydrogen charge-transfer collisions

    International Nuclear Information System (INIS)

    Glembocki, O.; Halpern, A.M.

    1977-01-01

    Theoretical angular distributions for p-H charge transfer to the 1s state for energies of 1 keV and above have been examined and compared for three approximation schemes: the plane-wave Born approximation of Jackson and Schiff (JS), the Coulomb projected Born approximation of Geltman (G), and the distorted-wave eikonal approximation of one of the authors (D). The sharp dip in the forward distribution characteristic of JS is found to exist in G and D as well. As expected, G and D give identical results for all but the lowest energies. In the cases of G and D the dip, which is located close to that of JS, disappears and then reappears as the energy rises. Analytic high-energy limits for the angular dependence in both the JS and G cases have been found and are discussed

  17. Influence of Waiting Time after Insertion of Base Chamber into Soil on Produced Greenhouse Gas Fluxes Influencia del Tiempo de Espera Después de la Inserción de la Base de la Cámara en el Suelo en los Flujos de Gases de Efecto Invernadero Producidos

    Directory of Open Access Journals (Sweden)

    Cristina Muñoz

    2011-12-01

    ámaras. Determinamos el efecto de la alteración del suelo asociada con la inserción de las cámaras sobre los flujos de óxido nitroso (N2O y metano (CH4 con y sin fertilización nitrogenada, desde un suelo con pradera en Nueva Zelandia. Colectamos muestras gaseosas desde las cámaras a 0, 2, 4, 24, 96 y 168 h después de la inserción de las cámaras. Nuestros resultados muestran elevados niveles de N2O al interior de las cámaras (1,7 veces las concentraciones atmosféricas del exterior de las cámaras y mayores flujos dentro de las primeras 4 h de instalación comparada a los valores observados a 24 h y posteriores; y flujos negativos de CH4 en el mismo período de tiempo, pero cercanos a cero después de 24 h. Nuestros resultados sugieren que para la medida exacta de los flujos de gases, la medición debe ser tomada después de 24 h de la inserción de las cámaras para evitar el efecto de la liberación de gases.

  18. About Eosinophilic Disorders

    Science.gov (United States)

    ... Matthew J. Ryan, MD Edisio J. Semeao, MD Raman Sreedharan, MBBS, DCH, MRCPCH Ritu Verma, MBChB Jessica ... 879-2467 Foundation 267-426-6500 Research 215-590-3800 Referring Physicians 1-800-879-2467 Explore ...

  19. NCBI nr-aa BLAST: CBRC-CREM-01-1327 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CREM-01-1327 ref|YP_922866.1| putative ABC antibiotics transporter [Nocardioid...es sp. JS614] gb|ABL81179.1| putative ABC antibiotics transporter [Nocardioides sp. JS614] YP_922866.1 3e-41 36% ...

  20. La representación popular y los desafíos del sistema electoral salvadoreño, 25 años después de la firma de los Acuerdos de Paz, un extracto

    Directory of Open Access Journals (Sweden)

    Félix Ulloa Garay

    2017-07-01

    Full Text Available Un cuarto de siglo después de la firma de los Acuerdos de Paz, El Salvador enfrenta una serie de desafíos democráticos que demandan reformas a su sistema político y electoral. Para comprender la urgencia de dichas reformas, se requiere un análisis prospectivo que proyecte ese nuevo sistema; pero que, a su vez, integre la visión retrospectiva donde se explican los hechos del pasado que dieron origen al conflicto armado. El sistema electoral fue uno de los 7 puntos de la Agenda de Caracas que guio la negociación hasta el acuerdo final de paz. Su desarrollo más pragmático que doctrinario, comprendió las reformas a la Constitución en 1991, cuando se creó la actual autoridad electoral, mediante un Tribunal Supremo Electoral, que sustituyó al viejo Consejo Central de Elecciones y un Código Electoral, que estableció rudimentarias reglas con las cuales se administraron cuatro elecciones presidenciales y seis elecciones legislativas y municipales. En este artículo se plantea la preocupación por la calidad de la representación popular y los mecanismos para su obtención, finalizando con recomendaciones para garantizar legítimamente su ejercicio. Estas propuestas, por venir del jurista italiano Luigi Ferrajoli, adquieren un valor universal y una aplicación a cualquier modelo de democracia liberal.

  1. Mastering web application development with Express

    CERN Document Server

    Vlăduțu, Alexandru

    2014-01-01

    If you are a Node.js developer who wants to take your Express skills to the next level and develop high performing, reliable web applications using best practices, this book is ideal for you. The only prerequisite is knowledge of Node.js.

  2. When family looks strange and strangers look normal : A case of impaired face perception and recognition after stroke

    NARCIS (Netherlands)

    Heutink, Joost; Brouwer, Wiebo H.; Kums, Evelien; Young, Andy; Bouma, Anke

    2012-01-01

    We describe a patient (JS) with impaired recognition and distorted visual perception of faces after an ischemic stroke. Strikingly, JS reports that the faces of family members look distorted, while faces of other people look normal. After neurological and neuropsychological examination, we assessed

  3. Animal remains of the Neolithic Ritual Burial Complex near Krum Village (Haskovo Region, SE Bulgaria

    Directory of Open Access Journals (Sweden)

    Zlatozar Boev

    2014-10-01

    Full Text Available From a total of 389 highly fragmented animal bone and tooth finds, dated ca. 6500-6300 B.P. have been identified 7 taxa: Lesser mole rat, Eurasian beaver, Cattle, Sheep, Goat, Pig, and Donkey.

  4. Infrared cross-sections and integrated band intensities of propylene: Temperature-dependent studies

    KAUST Repository

    Es-sebbar, Et-touhami; Alrefae, Majed; Farooq, Aamir

    2014-01-01

    intensities of propylene are essential for quantitative measurements and atmospheric modeling. We measured absolute IR cross-sections of propylene using Fourier Transform Infrared (FTIR) Spectroscopy over the wavenumber range of 400-6500cm-1 and at gas

  5. Jensen–Shannon information of the coherent system lifetime

    International Nuclear Information System (INIS)

    Asadi, Majid; Ebrahimi, Nader; Soofi, Ehsan S.; Zohrevand, Younes

    2016-01-01

    The signature of a coherent system with n components is an n-dimensional vector whose ith element is the probability that the ith failure of the components is fatal to the system. The signature depends only on the system design and provides useful tools for comparison of systems. We propose the Jensen–Shannon information (JS) criteria for comparison of systems, which is a scalar function of the signature and ranks systems based on their designs. The JS of a system is interpreted in terms of the remaining uncertainty about the system lifetime, the utility of dependence between the lifetime and the number of failures of components fatal to the system, and the Bayesian decision theory. The JS is non-negative and its minimum is attained by k-out-of-n systems, which are the least complex systems. This property offers JS as a measure of complexity of a system. Effects of expansion of a system on JS are studied. Application examples include comparisons of various sets of new systems and used but still working systems discussed in the literature. We also give an upper bound for the JS at the general level and compare it with a known upper bound. - Highlights: • Information criteria for comparing systems based on their structures are proposed. • The criteria only depend on the number of failures of its components. • The criteria rank systems based on the complexity of predicting their lifetimes. • The criteria apply to new system and system operating with failed components.

  6. Identification of flowering-related genes responsible for differences in bolting time between two radish inbred lines

    Directory of Open Access Journals (Sweden)

    Hye Sun Cho

    2016-12-01

    Full Text Available Late bolting after cold exposure is an economically important characteristic of radish (Raphanus sativus L., an important Brassicaceae root vegetable crop. However, little information is available regarding the genes and pathways that govern flowering time in this species. We performed high-throughput RNA sequencing analysis to elucidate the molecular mechanisms that determine the differences in flowering times between two radish lines, NH-JS1 (late bolting and NH-JS2 (early bolting. In total, 71,188 unigenes were identified by reference-guided assembly, of which 309, 788, and 980 genes were differentially expressed between the two inbred lines after 0, 15, and 35 days of vernalization, respectively. Among these genes, 218 homologs of Arabidopsis flowering-time (Ft genes were identified in the radish, and 49 of these genes were differentially expressed between the two radish lines in the presence or absence of vernalization treatment. Most of the Ft genes up-regulated in NH-JS1 vs NH-JS2 were repressors of flowering, such as RsFLC, consistent with the late-bolting phenotype of NH-JS1. Although the functions of genes down-regulated in NH-JS1 were less consistent with late-bolting characteristics than the up-regulated Ft genes, several Ft enhancer genes, including RsSOC1, a key floral integrator, showed an appropriate expression to the late-bolting phenotype. In addition, the patterns of gene expression related to the vernalization pathway closely corresponded with the different bolting times of the two inbred lines. These results suggest that the vernalization pathway is conserved between radish and Arabidopsis.

  7. Hematoma após raquianestesia tratado conservadoramente: relato de caso e revisão da literatura Hematoma después de raquianestesia tratado conservadoramente: relato de caso y revisión de la literatura Conservative treatment of hematoma after spinal anesthesia: case report and literature review

    Directory of Open Access Journals (Sweden)

    Daniel Segabinazzi

    2007-04-01

    objetivo de este trabajo fue describir un caso de hematoma después raquianestesia tratado de forma conservadora y revisar los trabajos en la literatura. RELATO DEL CASO: Paciente del sexo masculino, 73 años, 65 kg, 1,67 m, estado físico ASA III. Fue sometido a raquianestesia para retirada de catéter de diálisis peritoneal. Durante la realización de la punción hubo parestesias en el miembro inferior derecho. Se inyectaron 15 mg de bupivacaína hiperbárica a 0,5% sin vasoconstrictor. Veinte y cuatro horas después de la realización del bloqueo el paciente permanecía con anestesia en silla de montar y con dolor lumbar, y 48 horas después del procedimiento presentó una incontinencia urinaria. La resonancia nuclear magnética demostró la existencia de un proceso expansivo subaracnoideo, con compresión de raíces nerviosas (L4 a S1. Después de la evaluación del neurocirujano, se empieza el tratamiento conservador. El paciente recibió alta hospitalaria el 18° día de postoperatorio asintomático. CONCLUSIÓN: El caso presentado mostró una buena evolución con el tratamiento conservador.BACKGROUND AND OBJECTIVES: Spinal anesthesia caries the risk of bleeding. Compression of nervous tissue secondary to the formation of a hematoma can cause neurological damage, which, if not diagnosed and treated in a timely fashion, can be permanent. The identification of risk factors, diagnosis, and early treatment are important for the prognosis. The objective of this report was to describe the case of a hematoma after spinal anesthesia treated conservatively, and review the literature. CASE REPORT: Male patient, 73 years old, 65 kg, 1.67 m, and ASA physical status III, underwent spinal anesthesia for removal of a peritoneal dialysis catheter. During the puncture, the patient experienced paresthesia of the right lower limb. Fifteen milligrams of 0.5% hyperbaric bupivacaine without vasoconstrictor were administered. Twenty-four hours later, saddle anesthesia and lumbar pain

  8. 26 CFR 1.401-2 - Impossibility of diversion under the trust instrument.

    Science.gov (United States)

    2010-04-01

    ... than for the exclusive benefit of his employees or their beneficiaries” includes all objects or aims... employer, of the trust, or of some other person forming a part of the plan or connected with it. [T.D. 6500...

  9. 78 FR 69844 - Alaska Village Electric Cooperative, Inc.; Notice of Application Tendered for Filing With the...

    Science.gov (United States)

    2013-11-21

    ... CEO, AVEC, 4831 Eagle Street, Anchorage, AK 99503; Telephone (907) 561-1818. i. FERC Contact: Mary... system in Old Harbor. Transmission Line A 6,500-foot-long, 12.47-kV, 3-phase overhead power line will be...

  10. Smashing Nodejs JavaScript Everywhere

    CERN Document Server

    Rauch, Guillermo

    2012-01-01

    Learn to make more efficient apps, with just one language! Smashing Node.js: JavaScript Everywhere equips you with the necessary tools to understand Node.js and its uses in developing efficient web apps. With more traditional web servers becoming obsolete, having knowledge on servers that achieve high scalability and optimal resource consumption using Node.js is the key to your app development success. Teaching you the essentials to making event-driven server-side apps, this book demonstrates how you can use less space and take less time for communication between web client and server.Contains

  11. Joubert syndrome: large clinical variability and a unique neuroimaging aspect

    International Nuclear Information System (INIS)

    Leao, Emilia Katiane Embirucu; Lima, Marcilia Martyn; Kok, Fernando; Parizotto, Juliana; Maia Junior, Otacilio de Oliveira

    2010-01-01

    Joubert syndrome (JS) is an autosomal recessive inherited disorder characterized by hypotonia, cerebellar vermis hypoplasia, ocular abnormalities (e.g. pigmentary retinopathy, oculomotor apraxia and nystagmus), renal cysts and hepatic fibrosis. Respiratory abnormalities, as apnoea and hyperpnoea, may be present, as well as mental retardation. At least seven JS loci have been determined and five genes identified. Herein, we report five children, belonging to independent families, with JS: they shared the same typical MRI abnormality, known as molar tooth sign, but had an otherwise quite variable phenotype, regarding mostly their cognitive performance, visual abilities and extra-neurological compromise. (author)

  12. Joubert syndrome: large clinical variability and a unique neuroimaging aspect

    Energy Technology Data Exchange (ETDEWEB)

    Leao, Emilia Katiane Embirucu; Lima, Marcilia Martyn; Kok, Fernando; Parizotto, Juliana [University of Sao Paulo (USP), Sao Paulo, SP (Brazil). Clinical Hospital. Dept. of Child Neurology; Maia Junior, Otacilio de Oliveira [University of Sao Paulo (USP), Sao Paulo, SP (Brazil). Clinical Hospital. Dept. of Child Ophthalmology

    2010-04-15

    Joubert syndrome (JS) is an autosomal recessive inherited disorder characterized by hypotonia, cerebellar vermis hypoplasia, ocular abnormalities (e.g. pigmentary retinopathy, oculomotor apraxia and nystagmus), renal cysts and hepatic fibrosis. Respiratory abnormalities, as apnoea and hyperpnoea, may be present, as well as mental retardation. At least seven JS loci have been determined and five genes identified. Herein, we report five children, belonging to independent families, with JS: they shared the same typical MRI abnormality, known as molar tooth sign, but had an otherwise quite variable phenotype, regarding mostly their cognitive performance, visual abilities and extra-neurological compromise. (author)

  13. Production and characterization of human induced pluripotent stem cells (iPSCs from Joubert Syndrome: CSSi001-A (2850

    Directory of Open Access Journals (Sweden)

    Jessica Rosati

    2018-03-01

    Full Text Available Joubert Syndrome (JS is a rare autosomal recessive or X-linked condition characterized by a peculiar cerebellar malformation, known as the molar tooth sign (MTS, associated with other neurological phenotypes and multiorgan involvement. JS is a ciliopathy, a spectrum of disorders whose causative genes encode proteins involved in the primary cilium apparatus. In order to elucidate ciliopathy-associated molecular mechanisms, human induced pluripotent stem cells (hiPSCs were derived from a patient affected by JS carrying a homozygous missense mutation in the AHI1 gene (p.H896R that encodes a protein named Jouberin.

  14. Sapflow and water use of freshwater wetland trees exposed to saltwater incursion in a tidally influenced South Carolina watershed

    Science.gov (United States)

    Krauss, K.W.; Duberstein, J.A.

    2010-01-01

    Sea-level rise and anthropogenic activity promote salinity incursion into many tidal freshwater forested wetlands. Interestingly, individual trees can persist for decades after salt impact. To understand why, we documented sapflow (Js), reduction in Js with sapwood depth, and water use (F) of baldcypress (Taxodium distichum (L.) Rich.) trees undergoing exposure to salinity. The mean Js of individual trees was reduced by 2.8 g H2O??m-2??s-1 (or by 18%) in the outer sapwood on a saline site versus a freshwater site; however, the smallest trees, present only on the saline site, also registered the lowest Js. Hence, tree size significantly influenced the overall site effect on Js. Trees undergoing perennial exposure to salt used greater relative amounts of water in outer sapwood than in inner sapwood depths, which identifies a potentially different strategy for baldcypress trees coping with saline site conditions over decades. Overall, individual trees used 100 kg H2O??day-1 on a site that remained relatively fresh versus 23.9 kg H2O??day-1 on the saline site. We surmise that perennial salinization of coastal freshwater forests forces shifts in individual-tree osmotic balance and water-use strategy to extend survival time on suboptimal sites, which further influences growth and morphology.

  15. Comparison of crossover and jab step start techniques for base stealing in baseball.

    Science.gov (United States)

    Miyanishi, Tomohisa; Endo, So; Nagahara, Ryu

    2017-11-01

    Base stealing is an important tactic for increasing the chance of scoring in baseball. This study aimed to compare the crossover step (CS) and jab step (JS) starts for base stealing start performance and to clarify the differences between CS and JS starts in terms of three-dimensional lower extremity joint kinetics. Twelve male baseball players performed CS and JS starts, during which their motion and the force they applied to the ground were simultaneously recorded using a motion-capture system and two force platforms. The results showed that the normalised average forward external power, the average forward-backward force exerted by the left leg, and the forward velocities of the whole body centre of gravity generated by both legs and the left leg were significantly higher for the JS start than for the CS start. Moreover, the positive work done by hip extension during the left leg push-off was two-times greater for the JS start than the CS start. In conclusion, this study has demonstrated that the jab step start may be the better technique for a base stealing start and that greater positive work produced by left hip extension is probably responsible for producing its larger forward ground reaction force.

  16. Joubert syndrome: Clinical and radiological characteristics of nine patients

    Directory of Open Access Journals (Sweden)

    Ahmed Farag Elhassanien

    2013-01-01

    Full Text Available Background: Joubert Syndrome (JS is a rare genetic developmental disorder, first identified in 1969. In patients with JS, certain regions of the brain (mainly cerebellar vermis and brainstem are underdeveloped or malformed. This can lead to impaired attention, visual, spatial, motor, language and social functional skills. JS is characterized by a host of features, many of which do not occur in every patient. Aim of the Study: To spotlight and increase awareness of clinical profile and neuroimaging findings of children with Joubert syndrome. Methods: This is a retrospective case series study of patients with JS who attended the Pediatric Neurology Clinic in Aladan and Alfarawanya Hospitals in Kuwait, from September 2007 to September 2012. Clinical and radiological data were obtained from the patient medical records. Results: Cerebellar vermis hypoplasia/aplasia and apnea were present in all patients, polydactly in 3 of 16, renal problems with cysts in 5 patients and 11 of 16 had abnormal electroretinograms (ERGs. Blood investigations of organic acids, amino acids and very-long-chain fatty acid, were normal in the all the nine patients. Conclusion: JS is a rare genetic brain malformation with association of retinal dystrophy and renal abnormalities. The retinal dystrophy may be progressive. The prognosis of patients depends mainly on the degree of brain malformation.

  17. Conocimientos previos acerca de métodos anticonceptivos y su relación con conocimientos adquiridos después de una intervención educativa con simulador

    Directory of Open Access Journals (Sweden)

    María Neyfeth Posada Morales

    2015-01-01

    Full Text Available Introducción. El objetivo de este trabajo es relacionar conocimientos previos (pre-saberes acerca de métodos anticonceptivos con los conocimientos adquiridos (saberes, después una intervención educativa con simulador.Método. Es un estudio realizado con 295 adolescentes escolarizados que cursan noveno, décimo y undécimo en una institución educativa pública. Es de tipo descriptivo. El proceso estuvo compuesto por tres fases; en la primera se midió conocimientos o saberes previos acerca de métodos anticonceptivos, mediante un cuestionario auto-informado; en la segunda se definió los contenidos y actividades de intervención para mejorar los conocimientos previos, y en la tercera fase de post-intervención educativa, se reevaluó los saberes adquiridos con el simulador. Resultados. Se detectó que los pre-saberes en métodos anticonceptivos son deficientes independientemente de la edad y la escolaridad, lo cual requiere planeación, desarrollo y evaluación de la estrategia de aprendizaje colectivo y cooperativo mediante talleres. En cuanto a los post-saberes, se obtuvo una calificación de deficientes a regulares, en el caso del condón masculino, mientras que el reconocimiento de métodos modernos como parche, anillo vaginal, dispositivo intrauterino, entre otros, se dio gracias al contacto directo con el simulador.Conclusiones. Se recalca que a pesar de las  diferencias de edad y escolaridad, no hubo hallazgos relevantes que demostraran diferencias de conocimiento. En los pre-saberes, se encontró niveles de conocimiento deficientes sobre métodos anticonceptivos. El uso de simuladores como herramienta de aprendizaje demostró eficacia en los talleres; en cuanto a los simuladores posibilitan la ruptura de la barrera cognitiva, dado que el adolescente, en este caso, puede explorar y adquirir conocimiento al interaccionar con el objeto de aprendizaje.

  18. Determinação de dose absorvida em feixes de elétrons utilizado câmara de ionizacão de placas paralelas

    Directory of Open Access Journals (Sweden)

    Bulla Roseli T.

    2004-01-01

    Full Text Available OBJETIVO: O objetivo deste trabalho foi estabelecer um procedimento para a determinação dos fatores de calibração e de doses absorvidas em feixes de elétrons. MATERIAIS E MÉTODOS: Foram utilizados um irradiador de 60Co e um acelerador linear Varian, modelo Clinac 2100C, com feixes de fótons e de elétrons. Foram estudadas câmaras de ionização do tipo dedal e de placas paralelas. RESULTADOS: Os sistemas de medidas foram submetidos aos testes preliminares (estabilidade de resposta e corrente de fuga, com resultados muito bons. Quatro métodos de calibração de câmaras de ionização para utilização em feixes de elétrons foram testados. Para a determinação da dose absorvida em feixes de elétrons foram aplicadas três metodologias propostas pela Agência Internacional de Energia Atômica, com a obtenção de resultados concordantes em quase todos os casos. CONCLUSÃO: A maior parte das câmaras de ionização estudadas mostrou-se viável, com desempenho dentro dos limites internacionais estabelecidos.

  19. Manual versus automatic bladder wall thickness measurements: a method comparison study

    NARCIS (Netherlands)

    Oelke, M.; Mamoulakis, C.; Ubbink, D.T.; de la Rosette, J.J.; Wijkstra, H.

    2009-01-01

    Purpose To compare repeatability and agreement of conventional ultrasound bladder wall thickness (BWT) measurements with automatically obtained BWT measurements by the BVM 6500 device. Methods Adult patients with lower urinary tract symptoms, urinary incontinence, or postvoid residual urine were

  20. Murray Pittock, ed., The Edinburgh Companion to Scottish Romanticism.

    Directory of Open Access Journals (Sweden)

    Manfred Malzahn

    2013-10-01

    Full Text Available Murray Pittock, ed., The Edinburgh Companion to Scottish Romanticism. Edinburgh: Edinburgh University Press, 2011. Pp. 251. ISBN 978-0-7486-3845-1 (hardback. £ 65.00. ISBN 978-0-7486-3846-8 (paperback. £ 21.99.

  1. Reconstruction of the Sofia (Bulgaria) IRT-2000 research reactor

    International Nuclear Information System (INIS)

    Valenta, V.

    2006-01-01

    The history and structure of the original reactor are described, followed by a description of the new solution based on SKODA JS's design. The article focusses on the design of the reactor and spent fuel storage pool that have been developed and delivered by SKODA JS. (orig.)

  2. NCBI nr-aa BLAST: CBRC-XTRO-01-0887 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0887 ref|YP_548923.1| binding-protein-dependent transport systems inne...r membrane component [Polaromonas sp. JS666] gb|ABE44025.1| binding-protein-dependent transport systems inner membrane component [Polaromonas sp. JS666] YP_548923.1 5e-88 61% ...

  3. NCBI nr-aa BLAST: CBRC-LAFR-01-1532 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1532 ref|YP_987753.1| binding-protein-dependent transport systems inne...r membrane component [Acidovorax sp. JS42] gb|ABM43677.1| binding-protein-dependent transport systems inner membrane component [Acidovorax sp. JS42] YP_987753.1 0.61 25% ...

  4. Web-based hybrid-dimensional Visualization and Exploration of Cytological Localization Scenarios

    Directory of Open Access Journals (Sweden)

    Kovanci Gökhan

    2016-10-01

    Full Text Available The CELLmicrocosmos 4.2 PathwayIntegration (CmPI is a tool which provides hybriddimensional visualization and analysis of intracellular protein and gene localizations in the context of a virtual 3D environment. This tool is developed based on Java/Java3D/JOGL and provides a standalone application compatible to all relevant operating systems. However, it requires Java and the local installation of the software. Here we present the prototype of an alternative web-based visualization approach, using Three.js and D3.js. In this way it is possible to visualize and explore CmPI-generated localization scenarios including networks mapped to 3D cell components by just providing a URL to a collaboration partner. This publication describes the integration of the different technologies - Three.js, D3.js and PHP - as well as an application case: a localization scenario of the citrate cycle. The CmPI web viewer is available at: http://CmPIweb.CELLmicrocosmos.org.

  5. Comparison of the virulence of three H3N2 canine influenza virus isolates from Korea and China in mouse and Guinea pig models.

    Science.gov (United States)

    Xie, Xing; Na, Woonsung; Kang, Aram; Yeom, Minjoo; Yuk, Heejun; Moon, Hyoungjoon; Kim, Sung-Jae; Kim, Hyun-Woo; Kim, Jeong-Ki; Pang, Maoda; Wang, Yongshan; Liu, Yongjie; Song, Daesub

    2018-05-02

    Avian-origin H3N2 canine influenza virus (CIV) has been the most common subtype in Korea and China since 2007. Here, we compared the pathogenicity and transmissibility of three H3N2 CIV strains [Chinese CIV (JS/10), Korean CIV (KR/07), and Korean recombinant CIV between the classic H3N2 CIV and the pandemic H1N1 virus (MV/12)] in BALB/c mouse and guinea pig models. The pandemic H1N1 (CA/09) strain served as the control. BALB/c mice infected with H1N1 had high mortality and obvious body weight loss, whereas no overt disease symptoms were observed in mice inoculated with H3N2 CIV strains. The viral titers were higher in the group MV/12 than those in groups JS/10 and KR/07, while the mice infected with JS/10 showed higher viral titers in all tissues (except for the lung) than the mice infected with KR/07. The data obtained in guinea pigs also demonstrated that group MV/12 presented the highest loads in most of the tissues, followed by group JS/10 and KR/07. Also, direct contact transmissions of all the three CIV strains could be observed in guinea pigs, and for the inoculated and the contact groups, the viral titer of group MV/12 and KR/07 was higher than that of group JS/10 in nasal swabs. These findings indicated that the matrix (M) gene obtained from the pandemic H1N1 may enhance viral replication of classic H3N2 CIV; JS/10 has stronger viral replication ability in tissues as compared to KR/07, whereas KR/07 infected guinea pigs have more viral shedding than JS/10 infected guinea pigs. There exists a discrepancy in pathobiology among CIV isolates. Reverse genetics regarding the genomes of CIV isolates will be helpful to further explain the virus characteristics.

  6. Regeneración de un "aulagar" con Ulex europaeus después de un incendio en el norte de España

    Directory of Open Access Journals (Sweden)

    Vera de la Fuente, M. L.

    1994-12-01

    Full Text Available The recuperation of a shrubland characterized by the presence of Genista hispánica ssp. occidentalis, Ulex europaeus and Erica vagans after of a fire, near Oviedo (North Spain is studied. The regeneration strategy of Erica vagans was by means of vegetative regrowth. The recolonization of Ulex europaeus and Genista hispánica ssp. occidentalis was both vegetative and from seed, although in the last species the establishment by seedlings was very infrequent. The post-fire vegetation development was affected by floristic composition of shrubland previous to the fire.

    [es] Se estudia la recuperación de un matorral caracterizado por la presencia de Genista hispánica ssp. occidentalis, Ulex europaeus y Erica vagans después de un incendio, en las proximidades de Oviedo. La estrategia regenerativa de Erica vagans es mediante rebrote vegetativo, mientras Ulex europaeus y Genista hispánica ssp. occidentalis tienen capacidad de regenerarse por rebrote vegetativo y por semilla, aunque en este último taxon, el mecanismo de regeneración a través de plántulas fue muy escaso. El desarrollo de la vegetación está muy marcado por la composición florística previa al fuego.
    [fr] On à étudié la récupération de broussailles caractérisées par la présence de Genista hispánica ssp. occidentalis, Ulex europaeus et Erica vagans, après un incendie prés d’Oviedo (Nord de Espagne. La stratégie de régénération d’Erica vagans se fait moyennant des pousses végétatives, tandis que la régénération d’Ulex europaeus et Genista hispánica ssp. occidentalis s'esf faite par pousses végétatives et par graines, bien que pour ce dernier taxon, le mécanisme de régénération au travers de plantules a été très rare. Le développement de la végétation est très marqué par la composition floristique existante

  7. Effect of prolonged heating on the asphalt-aggregate bond strength of HMA containing liquid anti-strip additives

    Science.gov (United States)

    2008-09-01

    In this study, an attempt was made to determine the effect of prolonged heating on the bond strength between : aggregate and asphalt that contained anti-strip additives (LOF 6500 and Morelife 2200). On account of the : substantial decrease of anti-st...

  8. Impacts of Organizational Knowledge Sharing Practices on Employees' Job Satisfaction: Mediating Roles of Learning Commitment and Interpersonal Adaptability

    Science.gov (United States)

    Malik, Muhammad Shaukat; Kanwal, Maria

    2018-01-01

    Purpose: The purpose of this paper is to investigate empirically impacts of organizational knowledge-sharing practices (KSP) on employees' job satisfaction (JS), interpersonal adaptability (IA) and learning commitment (LC). Indirect effects of KSP on JS are also confirmed through mediating factors (LC and IA). Design/methodology/approach:…

  9. Impacts of DNAPL Source Treatment: Experimental and Modeling Assessment of the Benefits of Partial DNAPL Source Removal

    Science.gov (United States)

    2009-09-01

    this project: A. Noman M. Ahsanuzzaman, Steve Acree, Nandita Basu, Sten Berglund, Carol Bratt, Gordon Brown, Xaisong Chen, Jaehyun Cho, Pat Clark...A.S.C. Chen (eds). Chapelle, F.H., J.S. Widdowson, J.S. Bruner, E. Mendez , and C.C. Casey (2003). Methodology for Estimating Times of Remediation

  10. Performance of sorghum cultivars for biomass quality and biomethane yield grown in semi-arid area of Pakistan.

    Science.gov (United States)

    Hassan, Muhammad Umair; Chattha, Muhammad Umer; Mahmood, Athar; Sahi, Shahbaz Talib

    2018-05-01

    Biomass is a promising renewable energy source and its significance is escalating in the context of climate change and depletion of fossil foils. This study was conducted for two consecutive years 2016 and 2017, using five sorghum cultivars, i.e., JS-263, Jawar-2011, Hagari, JS-2002, and YS-2016, in order to determine the best cultivars in terms of dry matter yield, chemical composition, and biomethane yield grown under semi-arid conditions in Pakistan. The results revealed that sorghum cultivars responded differently in terms of growth, biomass yield, chemical composition, and methane yield. Cultivars Jawar-2011 produced maximum leaf area index, leaf area duration, crop growth rate, plant height, and leaves per plant, however, they were comparable with Sorghum-2016, whereas cultivar JS-2002 performed poorly among the tested cultivars. Similarly, cultivar Jawar-2011 produced maximum dry matter yield (16.37 t ha -1 ) similar to that of YS-2016, further cultivar JS-2002 performed poorly and gave lower dry matter yield (12.87 t ha -1 ). The maximum protein concentration (10.95), neutral detergent fibers (61.20), and lignin contents (5.55) found in Jawar-2011 were comparable with those in YS-2016, while the lowest neutral detergent fiber and lignin contents were found in JS-2002. Although JS-2002 produced the highest specific methane yield per kilogram of volatile solids, it was overcompensated by Jawar-2011 owing to higher dry matter yield per hectare. These results suggested that cultivar Jawar-2011 can be grown successfully in semi-arid conditions of Pakistan in order to get good biomass yield along with higher methane yield.

  11. Identification and application of biocontrol agents against Cotton leaf curl virus disease in Gossypium hirsutum under greenhouse conditions

    Directory of Open Access Journals (Sweden)

    Memoona Ramzan

    2016-05-01

    Full Text Available Biological control is a novel approach in crop protection. Bacteria, such as Bacillus spp. and Pseudomonas spp., are reported for this purpose and some of their products are already commercially available. In this study, the rhizosphere and phyllosphere of healthy cotton plants were used as a source of bacterial isolates with properties of potential biocontrol agents. The isolates were screened for phosphate solubilization activity, indole acetic acid (IAA production and antifungal activity. Two isolates, S1HL3 and S1HL4, showed phosphate solubilization and IAA production simultaneously, while another two, JS2HR4 and JS3HR2, demonstrated potential to inhibit fungal pathogens. These bacteria were identified as Pseudomonas aeruginosa (S1HL3, Burkholderia sp. (S1HL4 and Bacillus sp. (JS2HR4 and JS3HR2 based on biochemical and molecular characteristics. The isolates were tested against Cotton leaf curl virus (CLCuV in greenhouse conditions, both as individual bacterial isolates and consortia. Treated plants were healthy as compared to control plants, where up to 74% of the plants were symptomatic for CLCuV infection. Maximum inhibition of CLCuV was observed in the plants treated with a mixture of bacterial isolates: the viral load in the treated plants was only 0.4% vs. up to 74% in controls. This treatment consortium included P. aeruginosa S1HL3, Burkholderia sp. S1HL4 and Bacillus spp. isolates, JS2HR4 and JS3HR2. The principal-component biplot showed a highly significant correlation between the viral load percentage and the disease incidence.

  12. I Signori dell'annello

    CERN Multimedia

    Magrini, Marco

    2003-01-01

    They live as recluse, under the ground, for love of Science. They are 6'500 scientists of 80 countries who live in the greatest and most expensive Laboratory in the World. They aim to come back to the origins of Universe (2 pages)

  13. Temperature-dependent absorption cross-section measurements of 1-butene (1-C4H8) in VUV and IR

    KAUST Repository

    Es-sebbar, Et-touhami; Bé nilan, Yves; Farooq, Aamir

    2013-01-01

    synchrotron radiation as a tunable VUV light source. Fourier Transform Infrared (FTIR) spectroscopy is employed to measure absorption cross-section and band strengths in the IR region between 1.54 and 25μm (~6500-400cm-1). The measured room-temperature VUV

  14. 75 FR 19654 - U.S. Customs and Border Protection Agency Information Collection Activities: Customs-Trade...

    Science.gov (United States)

    2010-04-15

    ... change). Affected Public: Businesses, Individuals. Estimated Number of Respondents: 6,500. Estimated Time... previously approved. CBP is proposing that this information collection be extended with no change to the... other technological techniques or other forms of information. Title: Customs-Trade Partnership Against...

  15. Simulation of chamber experiments

    International Nuclear Information System (INIS)

    Ivanov, V.G.

    1981-01-01

    The description of the system of computer simulation of experiments conducted by means of track detectors with film data output is given. Considered is the principle of organization of computer model of the chamber experiment comprising the following stages: generation of events, generation of measurements, ge-- neration of scanning results, generation of distorbions, generated data calibration, filtration, events reconstruction, kinematic identification, total results tape formation, analysis of the results. Generation programs are formed as special RAM-files, where the RAM-file is the text of the program written in FORTRAN and divided into structural elements. All the programs are a ''part of the ''Hydra'' system. The system possibilities are considered on the base of the CDSC-6500 computer. The five-beam event generation, creation data structure for identification and calculation by the kinematic program take about 1s of CDC-6500 computer time [ru

  16. Examining a Proposed Job Retention Model for Adult Workers with Mental Retardation

    Science.gov (United States)

    Fornes, Sandra L.

    2008-01-01

    This research provides an analysis of factors predicting job retention (JR), job satisfaction (JS), and job performance (JP) of workers with mental retardation (MR). The findings highlight self-determination as a critical skill in influencing three important employee's outcomes, JR, JS, and JP. The intent of the study was to develop job retention…

  17. Relative Intensity Influences the Degree of Correspondence of Jump Squats and Push Jerks to Countermovement Jumps.

    Science.gov (United States)

    Cushion, Emily J; Goodwin, Jon E; Cleather, Daniel J

    2016-05-01

    The aim of this study was to determine the mechanical similarity between push jerk (PJ) and jump squat (JS) to countermovement jump (CMJ) and further understand the effect increasing external load may have on this relationship. Eight physically trained men (age 22 ± 3; height 176 ± 7 kg; weight 83 ± 8 kg) performed an unloaded CMJ followed by JS under a range of loads (10, 25, 35, and 50% 1RM back squat) and PJ (30, 50, 65, and 75% 1RM push jerk). A portable force platform and high-speed camera both collecting at 250 Hz were used to establish joint moments and impulse during the propulsive phase of the movements. A standard inverse dynamics model was used to determine joint moment and impulse at the hip, knee, and ankle. Significant correlations (p ≤ 0.05) were shown between CMJ knee joint moment and JS knee joint moment at 25% load and PJ knee joint moment at 30 and 50% load. Significant correlations were also observed between CMJ knee joint impulse and JS knee joint impulse at 10% load and PJ knee joint moment at 30 and 65% load. Significant correlation was also observed between CMJ hip joint impulse and PJ hip joint impulse at 30% load. No significant joint × load interaction was shown as load increased for either PJ or JS. Results from the study suggest partial correspondence between PJ and JS to CMJ, where a greater mechanical similarity was observed between the PJ and CMJ. This interaction is load and joint dependent where lower relative loads showed greatest mechanical similarity. Therefore using lower relative loads when programming may provide a greater transfer of training effect.

  18. Armigeres subalbatus colonization of damaged pit latrines

    NARCIS (Netherlands)

    Hiscox, A.; Hirooka, R.; Vongphayloth, K.; Hill, N.; Lindsay, S.W.; Grandadam, M.; Brey, P.T.

    2016-01-01

    During the resettlement of 6500 persons living around the Nam Theun 2 hydroelectric project in Laos, more than 1200 pour-flush latrines were constructed. To assess the role of these latrines as productive larval habitats for mosquitoes, entomological investigations using Centers for Disease

  19. Book Review: And then there were none: The demise of Desert Bighorn Sheep in the Pusch Ridge Wilderness

    Science.gov (United States)

    Cain, James W.

    2018-01-01

    And Then There Were None: The Demise of Desert Bighorn Sheep in the Pusch Ridge Wilderness. Paul R.Krausman. 2017. The University of New Mexico Press, Albuquerque, New Mexico, USA. 248 pp. $65.00 hardcover. ISBN 978‐0‐8263‐5785‐4.

  20. Effects of different enzymatic pre-press maceration treatments on the release of phenols into blackcurrant juice

    DEFF Research Database (Denmark)

    Bagger-Jørgensen, Rico; Meyer, Anne Boye Strunge

    2004-01-01

    ~6500 and 6650 mg gallic acid equivalents/L of total phenols, respectively. These levels correspond to increases of 14-15% compared to the juice extracted without enzymes, and were significantly higher than those achieved with Rapidase BE Super and Grindamyl pectinase treatments. Increased enzyme dosage...

  1. Human Impacts on Seals, Sea Lions, and Sea Otters: Integrating Archaeology and Ecology of the Northeast Pacific

    Directory of Open Access Journals (Sweden)

    Ray Pierotti

    2013-03-01

    Full Text Available Review of Human Impacts on Seals, Sea Lions, and Sea Otters: Integrating Archaeology and Ecology of the Northeast Pacific. Todd J. Braje and Torben C. Rick, editors. 2011. University of California Press, Berkeley. Pp. 328. $65.00 (hardcover. ISBN 9780520267268.

  2. Participative Decision-Making and Job Satisfaction for Teachers in the UAE

    Science.gov (United States)

    Al Nuaimi, Samira; Chowdhury, Hossan; Eleftheriou, Konstantinos; Katsioloudes, Marios I.

    2015-01-01

    Purpose: Knowledge of teachers' participative decision making (PDM) and job satisfaction (JS) is important, as teachers comprise most of a school's staff. The purpose of this paper is to examine the effect of teacher gender, nationality and school type on teachers' PDM and JS in Abu Dhabi's schools and to determine whether there any significant…

  3. Recoly, repositori de records : Webapp amb HTML5, CSS3 i JavaScript

    OpenAIRE

    Cantón Gavilán, Sergio

    2012-01-01

    Projecte d'implementació d'una aplicació web mòbil per enregistrar records amb LungoJS, PHP i MySQL. Estudi comparatiu de frameworks. Proyecto de implementación de una aplicación web móvil para grabar recuerdos con LungoJS, PHP y MySQL. Estudio comparativo de frameworks.

  4. Aptitud de padres para prevenir abuso sexual en menores después de una intervención educativa participativa Parental aptitude to prevent child sexual abuse after a participatory education intervention

    Directory of Open Access Journals (Sweden)

    Martha Alicia Higareda-Almaraz

    2011-04-01

    Full Text Available OBJETIVO: Evaluar la aptitud en los padres sobre el impacto de educar con equidad a los menores, para prevenir abuso sexual infantil con una estrategia educativa participativa. MATERIAL Y MÉTODOS: Diseño cuasiexperimental. Se incluyó a 92 padres con hijos menores en preescolar que recibieron una intervención educativa con estrategia promotora participativa por una hora durante 20 días. Para evaluar el cambio de aptitud se construyó previamente un cuestionario estructurado con 20 enunciados, que fue validado por expertos en educación y sexología infantil. Para comparar la diferencia intragrupos se utilizó Wilcoxon. RESULTADOS: Se encontraron diferencias estadísticamente significativas en las respuestas de los padres antes/después de la intervención educativa con un valor en la mediana (rango 10(2-12/18(6-20, pOBJECTIVE: To evaluate the aptitude of parents regarding the educational impact of equity education for children to prevent child sexual abuse using participatory strategies. MATERIAL AND METHODS: Quasi-experimental design. Ninety-two parents with children in preschool were included in the study. The parents were given a course using participatory educational strategies for one hour daily over a period of 20 days. Prior to the course, a group of experts in child education and sexology prepared a questionnaire with 20 sentences. A Wilcoxon test was used to compare intergroup differences RESULTS: We found statistically significant differences in the parents' responses before and after the educational intervention, with a median (range of 10(2-12/18(6-20, p<0.01. CONCLUSIONS: A significant change in aptitude was noted when parents attended classes using a participatory strategy to learn about the impact of educational equity for the prevention of child sexual abuse. Thus, it is imperative to continue evaluating different educational strategies.

  5. Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.).

    Science.gov (United States)

    Choi, Ji Won; Synytsya, Andriy; Capek, Peter; Bleha, Roman; Pohl, Radek; Park, Yong Il

    2016-08-01

    A water-soluble polysaccharide JS-MP-1 was isolated from Korean mulberry fruits Oddi (Morus alba L.). Sugar linkage analysis and NMR data confirmed that it is a rhamnogalacturonan type I (RG I) polymer carrying arabinan and arabinogalactan (AG II) side chains. JS-MP-1 reduced dose-dependently the viability of 3T3-L1 pre-adipocyte cells, significantly stimulated the cleavage of caspases 9 and 3 and poly (ADP-ribose) polymerase (PARP) and decreased the ratio of Bcl-2 to Bax expression level that led to mitochondrial dysfunction and apoptosis in pre-adipocyte cells. The apoptotic death was mediated by stimulation of MAPKs (ERK and p38) signalling pathway. These results suggest that JS-MP-1 is able to reduce the number of fat cells and the mass of adipose tissue via inhibition of pre-adipocyte proliferation and thus JS-MP-1 itself or a crude aqueous Oddi extract containing this polysaccharide can be used as functional ingredient of health-beneficial food supplements for the treatment or prevention of obesity disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Data visualization with D3.js cookbook

    CERN Document Server

    Zhu, Nick Qi

    2013-01-01

    Packed with practical recipes, this is a step-by-step guide to learning data visualization with D3 with the help of detailed illustrations and code samples.If you are a developer familiar with HTML, CSS, and JavaScript, and you wish to get the most out of D3, then this book is for you. This book can also serve as a desktop quick-reference guide for experienced data visualization developers.

  7. BatchJS: Implementing Batches in JavaScript

    NARCIS (Netherlands)

    D. Kasemier

    2014-01-01

    htmlabstractNone of our popular programming languages know how to handle distribution well. Yet our programs interact more and more with each other and our data resorts in databases and web services. Batches are a new addition to languages that can finally bring native support for distribution to

  8. Polarization Orientation Dependence of the Far Infrared Spectra of Oriented Single Crystals of 1,3,5-trinitro-S-triazine (RDX) using Terahertz Time-Domain Spectroscopy

    Science.gov (United States)

    2009-01-01

    BE, Hogbin MR, Kemp MC (2007) Proc IEEE 95:1559 14. Laman N, Sree Harsha S, Grischkowsky D, Melinger JS (2008) Opt Express 16:4094 15. Melinger JS... Laman N, Grischkowsky D (2008) Appl Phy Lett 93:011102 16. Tribe WR, Newnham DA, Taday PF, Kemp MC (2004) Proc SPIE 5354:168 17. Watters DG, Falconer DG

  9. Holocene flooding history of the Lower Tagus Valley (Portugal)

    NARCIS (Netherlands)

    Vis, G.-J.; Bohncke, S.J.P.; Schneider, H.; Kasse, C.; Coenraads-Nederveen, S.; Zuurbier, K.; Rozema, J.

    2010-01-01

    The present paper aims to reconstruct the Lower Tagus Valley flooding history for the last ca. 6500 a, to explore the suitability of pollen-based local vegetation development in supporting the reconstruction of flooding history, and to explain fluvial activity changes in terms of allogenic (climate,

  10. Remote input/output station

    CERN Multimedia

    1972-01-01

    A general view of the remote input/output station installed in building 112 (ISR) and used for submitting jobs to the CDC 6500 and 6600. The card reader on the left and the line printer on the right are operated by programmers on a self-service basis.

  11. SUPERCOLLIDER: String test success

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    On 14 August at the Superconducting Supercollider (SSC) Laboratory in Ellis County, Texas, the Accelerator Systems String Test (ASST) successfully met its objective by operating a half-cell of five collider dipole magnets, one quadrupole magnet, and two spool pieces at the design current of 6500 amperes

  12. "Star Wars" on Campus: Scientists Debate the Wisdom of SDI.

    Science.gov (United States)

    Rosenblatt, Jean

    1987-01-01

    President Reagan's Strategic Defense Initiative is opposed by many university scientists, but government officials have no problem placing research contracts. Specific arrangements and personal opinions are cited, and the text of the Star Wars Petition signed by 6,500 faculty and graduate student scientists is included. (MSE)

  13. Evaluatie bromfiets-theoriecertificaat : een onderzoek naar de korte-termijneffecten van de invoering van het theoriecertificaat.

    NARCIS (Netherlands)

    Twisk, D.A.M. Bijleveld, F.D. & Gundy, C.M.

    1998-01-01

    Since 1996, moped and low-speed moped riders have been required to possess a theory certificate, in the Netherlands. This evaluation study had focused on the intended and unintended side effects of introducing this measure. An average of 6,500 theory examinations for prospective moped riders are

  14. 26 CFR 1.6091-1 - Place for filing returns or other documents.

    Science.gov (United States)

    2010-04-01

    ... filing certain information returns. (1) For the place for filing returns of partnership income, see... filing information returns relating to formation or reorganization of foreign corporations, see paragraph... partnership taxable years beginning after April 29, 2008. [T.D. 6500, 25 FR 12108, Nov. 26, 1960, as amended...

  15. Program for calculating multi-component high-intense ion beam transport

    International Nuclear Information System (INIS)

    Kazarinov, N.Yu.; Prejzendorf, V.A.

    1985-01-01

    The CANAL program for calculating transport of high-intense beams containing ions with different charges in a channel consisting of dipole magnets and quadrupole lenses is described. The equations determined by the method of distribution function momenta and describing coordinate variations of the local mass centres and r.m.s. transverse sizes of beams with different charges form the basis of the calculation. The program is adapted for the CDC-6500 and SM-4 computers. The program functioning is organized in the interactive mode permitting to vary the parameters of any channel element and quickly choose the optimum version in the course of calculation. The calculation time for the CDC-6500 computer for the 30-40 m channel at the integration step of 1 cm is about 1 min. The program is used for calculating the channel for the uranium ion beam injection from the collective accelerator into the heavy-ion synchrotron

  16. Espirometria de incentivo com pressão positiva expiratória é benéfica após revascularização miocardio Espirometría incentivada con presión positiva espiratoria es beneficiosa después de revascularización de miocardio Incentive spirometry with expiratory positive airway pressure brings benefits after myocardial revascularization

    Directory of Open Access Journals (Sweden)

    Glória Menz Ferreira

    2010-02-01

    Full Text Available FUNDAMENTO: Pacientes que são submetidos à cirurgia de revascularização do miocárdio (CRM apresentam risco maior para desenvolver complicações pulmonares, como atelectasias, pneumonia e derrame pleural. Estas complicações podem aumentar o tempo de internação hospitalar, a necessidade de recursos financeiros e também se associam com a redução da qualidade de vida e da capacidade funcional a longo prazo. OBJETIVO: Testar se o uso de espirometria de incentivo (EI associada com pressão positiva expiratória na via aérea (EPAP, após CRM melhora a dispneia, a sensação de esforço percebido e a qualidade de vida 18 meses após a CRM. MÉTODOS: Dezesseis pacientes submetidos a CRM foram randomizados para o grupo controle (n=8 ou para o grupo EI+EPAP (n=8. O protocolo de EI+EPAP foi realizado no período pós-operatório imediato e durante mais 4 semanas no domicílio. Dezoito meses após a CRM foram avaliadas a força da musculatura respiratória, a capacidade funcional, a função pulmonar, a qualidade de vida e o nível de atividade física. RESULTADOS: Após o teste de caminhada de seis minutos (TC6, o escore para dispneia (1,6±0,6 vs 0,6±0,3, PFUNDAMENTO: Pacientes que son sometidos a cirugía de revascularización del miocardio (CRM presenta mayor riesgo de desarrollar complicaciones pulmonares, como atelectasias, neumonía y derrame pleural. Estas complicaciones pueden aumentar el tiempo de internación hospitalaria, la necesidad de recursos financieros y también se asocian con la reducción de la calidad de vida y de la capacidad funcional a largo plazo. OBJETIVO: Probar si el uso de espirometría incentivada (EI asociada con presión positiva espiratoria en la vía aérea (EPAP, después de la CRM mejora la disnea, la sensación de esfuerzo percibido y la calidad de vida 18 meses después de la CRM. MÉTODOS: Dieciocho pacientes sometidos a CRM fueron aleatorizados para el grupo control (n=8 o para el grupo EI+EPAP (n=8. El

  17. El médico de familia y el control de la sífilis después de una estrategia de intervención The family physician and the control of syphilis after an intervention strategy

    Directory of Open Access Journals (Sweden)

    Denis Berdasquera Corcho

    2006-09-01

    Full Text Available Se realizó un estudio experimental con control histórico antes y después de la intervención durante los meses de mayo de 2001 a agosto de 2003. El universo lo constituyeron los 39 Médicos de Familia que laboran en los consultorios del municipio. En Guanajay, desde hace varios años se han presentado dificultades en el tratamiento de las infecciones de transmisión sexual por parte de los Médicos de Familia, hecho que ha propiciado que se incumplan indicadores del Programa de Control de la Sífilis. Por tales razones se decidió intervenir, y realizar primeramente un estudio para determinar el nivel de conocimientos que sobre el control de la sífilis tenían los médicos del municipio, y aplicar posteriormente una intervención para disminuir las deficiencias encontradas. Solo el 43,6 % de los médicos obtuvieron evaluaciones satisfactorias antes de la intervención, que aumentaron a un 94,6 % de respuestas correctas después de aplicada la estrategia. Las mayores deficiencias se encontraron en el dominio de las funciones y objetivos del Programa, en el diagnóstico clínico y de laboratorio, en la vigilancia y grupos de riesgo, en el diagnóstico clínico y tratamiento, así como en las acciones de educación para la salud y la gravedad de la sífilis. El nivel de conocimientos sobre el Programa no era satisfactorio en la mayoría de los encuestados antes de la intervención. La estrategia empleada resultó ser eficaz en lograr conocimientos más sólidos por parte de los médicos en cuanto al control de la sífilis en su comunidad, lo que pudiera favorecer un mejor control de los pacientes que la padecen en el municipio.An experimental study with historical control before and after the intervention was conducted from May to August, 2003.The universe was composed of 39 family physicians working in the offices of the municipality. The family physicians have had difficulties to treat sexually transmitted diseases for some years, and as a

  18. Obstrução de vias aéreas superiores após drenagem de abscesso periamigdaliano: relato de caso Obstrucción de vías aéreas superiores después de drenaje de absceso periamigdaliano: relato de caso Upper airway obstruction after peritonsillar abscess drainage: case report

    Directory of Open Access Journals (Sweden)

    Deoclécio Tonelli

    2002-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O abscesso periamigdaliano é uma complicação incomum, porém predispõe a comprometimento grave das vias aéreas superiores. O objetivo deste relato é apresentar um caso de obstrução de vias aéreas após drenagem cirúrgica de abscesso periamigdaliano numa paciente jovem sem outras doenças de base. RELATO DO CASO: Trata-se de uma paciente de 26 anos com grave abscesso periamigdaliano que submeteu-se à anestesia geral para drenagem e após a extubação apresentou grave insuficiência respiratória, necessitando de reintubação traqueal e ventilação controlada mecânica por 24 horas. CONCLUSÕES: O planejamento anestésico e a adequada indicação cirúrgica são fundamentais para a prevenção de complicações em cirurgia otorrinolaringológica.JUSTIFICATIVA Y OBJETIVOS: El absceso periamigdaliano es una complicación incomún, sin embargo predisponen al comprometimiento grave de las vías aéreas superiores. El objetivo de este relato es presentar un caso de obstrucción de las vías aéreas después de drenaje quirúrgico de absceso periamigdaliano en una paciente joven sin otras enfermedades de base. RELATO DE CASO: Se trata de una paciente de 26 años con grave absceso periamigdaliano que se sometió a anestesia general para drenaje y después de la extubación presentó grave insuficiencia respiratoria, necesitando de reintubación traqueal y ventilación controlada mecánica por 24 horas. CONCLUSIONES: El planeamiento anestésico y la adecuada indicación quirúrgica son fundamentales para la prevención de complicaciones en cirugía otorrinolaringológica.BACKGROUND AND OBJECTIVES: Peritonsillar abscess is an unusual complication, but predisposes to severe upper airway complications. This report aimed at presenting a case of upper airway obstruction after surgical drainage of a peritonsillar abscess in a healthy young female patient. CASE REPORT: Young female patient, 26 years old, with severe

  19. Characterization of X-ray irradiator RS-2000; Caracterizacao do irradiador de raios X RS-2000

    Energy Technology Data Exchange (ETDEWEB)

    Mazaro, Sarah Jessica; Pavoni, Juliana Fernandes [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Departamento de Fisica; Silva, Maelson do Nascimento; Bianchini, Adriano L.B.; Amaral, Leonardo Lira do, E-mail: sarahmazaro@yahoo.com.br [Universidade de Sao Paulo (HC/FMRP/USP), Ribeirao Preto, SP (Brazil). Hospital das Clinicas. Faculdade de Medicina. Servico de Radioterapia

    2014-04-15

    Gamma irradiators are being replaced by the x - rays ones which are more economical and have greater safety benefits compared to the radionuclide irradiators. Some tests are usually performed to ensure quality control while working with radiation, as constancy, linearity, repeatability, reproducibility, radiometric survey and security tests. Evaluating the technical parameters and the instrument and equipment performance quickly. The irradiator characterization determines its operation, by ensuring that the deposited dose is the one desired. This study aims to characterize x-rays irradiators through dosimetric tests. The equipment used in this study stable in dose rate free space and regularity for safety test. Furthermore, the measurements were reproducible with a maximum variation of 10% and the radiometric survey showed that the results are consistent with the exemption requirements of radiological protection described in regulatory position 3.01/001:2011. (author)

  20. Targeting the UPR to Circumvent Endocrine Resistance in Breast Cancer

    Science.gov (United States)

    2016-12-01

    cells, and re-sensitize resistant cells, to both estrogen withdrawal (analogous to treatment with an AI ) and to two different classes of AE (TAM and...following hits for NPPTA-TsOH and JS20- TsOH: NPPTA-TsOH: c-KIT<PDGFRB<FLT-3 JS20-TsOH: MEK6<NEK1 Future directions and publication(s): Currently

  1. Zn I spectra in the 1300–6500 cm.sup.-1./sup. range

    Czech Academy of Sciences Publication Activity Database

    Civiš, Svatopluk; Ferus, Martin; Chernov, Vladislav E.; Zanozina, Ekaterina; Juha, Libor

    2014-01-01

    Roč. 134, FEB 2014 (2014), s. 64-73 ISSN 0022-4073 R&D Projects: GA ČR GAP208/10/2302; GA ČR(CZ) GAP108/11/1312; GA ČR GAP205/11/0571; GA ČR GA13-28721S Institutional support: RVO:61388955 ; RVO:68378271 Keywords : Rydberg states * Time-resolved FTIR spectroscopy * Transition probabilities Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.645, year: 2014

  2. Tratamiento de una sesión de la fobia específica a las arañas en niños

    Directory of Open Access Journals (Sweden)

    Graciela Bermúdez-Ornelas

    2008-01-01

    Full Text Available Este estudio se propuso explorar el efecto del tratamiento de una sesión conductual de la fobia específica, diseñado por Öst, sobre las conductas de acercamiento y manipulación de las arañas por parte de niños con diagnóstico de fobia específica y su ansiedad, según la percepción de sus padres, una semana, tres y seis meses después del tratamiento. El estudio cuasiexperimental empleó un diseño de serie temporal interrumpida simple. Se aplicó la intervención en forma individual a 10 niños, entre 7 y 12 años, diagnosticados con fobia específica a las arañas. Se evaluó, antes, una semana después del tratamiento, tres y seis meses después, la respuesta de aproximación de los niños a las arañas y su ansiedad/depresión de acuerdo con el informe de sus padres. Se observaron mejoras estadística y clínicamente significativas después del tratamiento y tres meses después en todos los niños. La mejoría se mantuvo a los seis meses después del tratamiento para seis de los siete niños que terminaron el estudio. Los hallazgos se discuten a la luz de su relevancia clínica. Se repiten los resultados de estudios anteriores sobre la eficacia del tratamiento de una sesión en niños latinoamericanos.

  3. 78 FR 40265 - Notice of Final Federal Agency Action on Proposed Bridge Replacement in Massachusetts

    Science.gov (United States)

    2013-07-03

    ...-3275, [email protected]dot.gov . For Massachusetts Department of Transportation (MassDOT) Highway Division: Michael Bastoni, Project Manager, MassDOT Highway Division, 10 Park Plaza, Room 6500, Boston, MA 02116, 9...-02157. The EA, FONSI and other project records are available by contacting MassDOT at the address...

  4. 76 FR 77111 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-12-12

    ..., 6500 South MacArthur Blvd., Oklahoma City, OK 73169 or 4. The National Archives and Records... to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., Amdt 3D, CANCELLED Fort Hood/Killeen, TX, Robert Gray AAF, RADAR-1, Orig New Market, VA, New Market...

  5. Special collection of used mercury batteries in Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Schaerer, J

    1979-01-01

    The organization and the performance of the Swiss Mercury Battery Collection Service are described. The amount of mercury batteries returned has increased from 1800 kg (600 kg Hg) in 1975 to 6500 kg (2200 kg Hg) in 1978; the percentage of batteries returned increased from 20 to 55%. (DLC)

  6. Carbon dioxide assist for non-aqueous sodium–oxygen batteries

    KAUST Repository

    Das, Shyamal K.; Xu, Shaomao; Archer, Lynden A.

    2013-01-01

    We report a novel non-aqueous Na-air battery that utilizes a gas mixture of CO2 and O2. The battery exhibits a high specific energy of 6500-7000 Whkg- 1 (based on the carbon mass) over a range of CO2 feed compositions. The energy density achieved

  7. Global dynamics of dispersal and diversification among passerine birds

    DEFF Research Database (Denmark)

    Kennedy, Jonathan David

    2017-01-01

    , and the capacity of different geographic areas to preserve taxa through time. Here, I assess the relationships among these processes, to elucidate the causes of geographic and taxonomic variation in species richness among the most speciose order of birds: the Passeriformes (c. 6,500 species). To achieve this, I...

  8. Quarantine treatment in eggs of Stenoma catenifer Walsingham (Lepidoptera: Elachistidae), with gamma radiation of Cobalt-60; Tratamento quarentenário em ovos de Stenoma catenifer Walsingham (Lepidoptera: Elachistidae), com radiação gama do Cobalto-60

    Energy Technology Data Exchange (ETDEWEB)

    Silva, L. K.F.; Arthur, V.; Nava, D. E.; Parra, J. R.P.

    2006-10-15

    The objective of this work has been to determine the lethal dose of gamma radiation of Cobalt-60 for the Stenoma catenifer eggs. For the irradiation of the eggs an irradiador Gammacell-220 (CO60) was utilized, (Rate dose: 1.054 kGY/h). The doses were: 0, 25, 50, 75, 100, 125 and 150 Gy, 90 eggs/dose (six repetitions). The number of caterpillars emerged was evaluated, and the survivors growed in seeds of avocado. The adults obtained were coupled with normal insects, growed in boxes with double face paper containing the food (10% honey) and a fruit of avocado. The experimental design was totally random, being the data submitted to the analysis of the varianza and the averages compared by the test of Tukey (P=5%). The emergence of caterpillars from the treated eggs with dose of 0, 25 and 50 Gy was verified. The dose of 50 Gy caused deformation in the caterpillars emerged. The effect of the gamma radiation in the viability of the eggs was proportional to the dose increase. The adults from the eggs dealt with 25 Gy presented non viabilty of 92,85 and 100% for male and female, respectively. A radiation gamma of 75 Gy is recommended for treatment quarantine for avocado fruits infested with of S. catenifer eggs.

  9. Quarantine treatment in eggs of Stenoma catenifer Walsingham (Lepidoptera: Elachistidae), with gamma radiation of Cobalt-60

    International Nuclear Information System (INIS)

    Silva, L.K.F.; Arthur, V.; Nava, D.E.; Parra, J.R.P.

    2006-01-01

    The objective of this work has been to determine the lethal dose of gamma radiation of Cobalt-60 for the Stenoma catenifer eggs. For the irradiation of the eggs an irradiador Gammacell-220 (CO60) was utilized, (Rate dose: 1.054 kGY/h). The doses were: 0, 25, 50, 75, 100, 125 and 150 Gy, 90 eggs/dose (six repetitions). The number of caterpillars emerged was evaluated, and the survivors growed in seeds of avocado. The adults obtained were coupled with normal insects, growed in boxes with double face paper containing the food (10% honey) and a fruit of avocado. The experimental design was totally random, being the data submitted to the analysis of the varianza and the averages compared by the test of Tukey (P=5%). The emergence of caterpillars from the treated eggs with dose of 0, 25 and 50 Gy was verified. The dose of 50 Gy caused deformation in the caterpillars emerged. The effect of the gamma radiation in the viability of the eggs was proportional to the dose increase. The adults from the eggs dealt with 25 Gy presented non viabilty of 92,85 and 100% for male and female, respectively. A radiation gamma of 75 Gy is recommended for treatment quarantine for avocado fruits infested with of S. catenifer eggs

  10. A comparison of job satisfaction of community health workers before and after local comprehensive medical care reform: a typical field investigation in Central China.

    Science.gov (United States)

    Ding, Hong; Sun, Xin; Chang, Wei-wei; Zhang, Liu; Xu, Xi-ping

    2013-01-01

    The government of China promulgated new medical care reform policies in March 2009. After that, provincial-level governments launched new medical care reform which focusing on local comprehensive medical care reform (LCMR). Anhui Province is an example of an area affected by LCMR, in which the LCMR was started in October 2009 and implemented in June 2010. The objective of this study was to compare the job satisfaction (JS) of community health workers (CHWs) before and after the reform in Anhui Province. A baseline survey was carried out among 813 community health workers (CHWs) of 57 community health centers (CHCs) (response rate: 94.1%) and an effect evaluation survey among 536 CHWs of 30 CHCs (response rate: 92.3%) in 2009 and 2012 respectively. A self-completion questionnaire was used to assess the JS of the CHWs (by the job satisfaction scale, JSS). The average scores of total JS and satisfaction with pay, contingent rewards, operating procedures and communication in the effect evaluation survey were statistically significantly higher than those of the baseline survey (Pwork reward of CHWs and pay more attention to CHWs' professional development to further increase their JS.

  11. The Shepherd's Crook Sign: A New Neuroimaging Pareidolia in Joubert Syndrome.

    Science.gov (United States)

    Manley, Andrew T; Maertens, Paul M

    2015-01-01

    By pareidolically recognizing specific patterns indicative of particular diseases, neuroimagers reinforce their mnemonic strategies and improve their neuroimaging diagnostic skills. Joubert Syndrome (JS) is an autosomal recessive disorder characterized clinically by mental retardation, episodes of abnormal deep and rapid breathing, abnormal eye movements, and ataxia. Many neuroimaging signs characteristic of JS have been reported. In retrospective case study, two consanguineous neonates diagnosed with JS were evaluated with brain magnetic resonance imaging (MRI), computed tomography (CT), and neurosonography. Both cranial ultrasound and MRI of the brain showed the characteristic molar tooth sign. There was a shepherd's crook in the sagittal views of the posterior fossa where the shaft of the crook is made by the brainstem and the pons. The arc of the crook is made by the abnormal superior cerebellar peduncle and cerebellar hemisphere. By ultrasound, the shepherd's crook sign was seen through the posterior fontanelle only. CT imaging also showed the shepherd's crook sign. Neuroimaging diagnosis of JS, which already involves the pareidolical recognition of specific patterns indicative of the disease, can be improved by recognition of the shepherd's crook sign on MRI, CT, and cranial ultrasound. Copyright © 2014 by the American Society of Neuroimaging.

  12. An effective inversion algorithm for retrieving bimodal aerosol particle size distribution from spectral extinction data

    International Nuclear Information System (INIS)

    He, Zhenzong; Qi, Hong; Yao, Yuchen; Ruan, Liming

    2014-01-01

    The Ant Colony Optimization algorithm based on the probability density function (PDF-ACO) is applied to estimate the bimodal aerosol particle size distribution (PSD). The direct problem is solved by the modified Anomalous Diffraction Approximation (ADA, as an approximation for optically large and soft spheres, i.e., χ⪢1 and |m−1|⪡1) and the Beer–Lambert law. First, a popular bimodal aerosol PSD and three other bimodal PSDs are retrieved in the dependent model by the multi-wavelength extinction technique. All the results reveal that the PDF-ACO algorithm can be used as an effective technique to investigate the bimodal PSD. Then, the Johnson's S B (J-S B ) function and the modified beta (M-β) function are employed as the general distribution function to retrieve the bimodal PSDs under the independent model. Finally, the J-S B and M-β functions are applied to recover actual measurement aerosol PSDs over Beijing and Shanghai obtained from the aerosol robotic network (AERONET). The numerical simulation and experimental results demonstrate that these two general functions, especially the J-S B function, can be used as a versatile distribution function to retrieve the bimodal aerosol PSD when no priori information about the PSD is available. - Highlights: • Bimodal PSDs are retrieved by ACO based on probability density function accurately. • J-S B and M-β functions can be used as the versatile function to recover bimodal PSDs. • Bimodal aerosol PSDs can be estimated by J-S B function more reasonably

  13. Anatomical explanations for acute depressions in radial pattern of axial sap flow in two diffuse-porous mangrove species: implications for water use.

    Science.gov (United States)

    Zhao, Hewei; Yang, Shengchang; Guo, Xudong; Peng, Congjiao; Gu, Xiaoxuan; Deng, Chuanyuan; Chen, Luzhen

    2018-02-01

    Mangrove species have developed uniquely efficient water-use strategies in order to survive in highly saline and anaerobic environments. Herein, we estimated the stand water use of two diffuse-porous mangrove species of the same age, Sonneratia apetala Buch. Ham and Sonneratia caseolaris (L.) Engl., growing in a similar intertidal environment. Specifically, to investigate the radial patterns of axial sap flow density (Js) and understand the anatomical traits associated with them, we measured axial sap flow density in situ together with micromorphological observations. A significant decrease of Js was observed for both species. This result was accompanied by the corresponding observations of wood structure and blockages in xylem sapwood, which appeared to influence and, hence, explained the acute radial reductions of axial sap flow in the stems of both species. However, higher radial resistance in sapwood of S. caseolaris caused a steeper decline of Js radially when compared with S. apetala, thus explaining the latter's more efficient use of water. Without first considering acute reductions in Js into the sapwood from the outer bark, a total of ~55% and 51% of water use would have been overestimated, corresponding to average discrepancies in stand water use of 5.6 mm day-1 for S. apetala trees and 2.5 mm day-1 for S. caseolaris trees. This suggests that measuring radial pattern of Js is a critical factor in determining whole-tree or stand water use. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Quantitative stress-redistribution planar T1-201 scintigraphy: Assessment of the extent of hypoperfused myocardium by relationship to angiographic findings

    International Nuclear Information System (INIS)

    Bassir, R.; Maddahi, J.; Garcia, E.

    1984-01-01

    The size of hypoperfused myocardium (HM) in coronary artery (CA) disease (D) potentially provides a prognostic index that may not be accurately assess by conventional angiographic classification. The authors studied 62 consecutive patients (pts) with planar stress-redistribution T1-201 scintigraphy (T1-201) and coronary arteriography who did not have prior myocardial infarction and achieved 85% predicted maximum heart rate on exercise. Of 62 pts, 42 had CAD (>50% stenosis). For T1-201 quantification of the size of HM, maximum count circumferential profiles of initial distribution and % washout were obtained and compared to previously established normal limits. The area enclosed between the normal limits and the abnormal portion of the pt's profiles represented a quantitative T1-201 jeopardy score (JS). Despite increasing T1-201 JS from 1 to 3 vessel (V) and left-main (LM) D, significant overlap between the different angiographic groups was observed; of 45 pts with mild JS (<300), 14 (31%) had 3VD and/or LMD. The angiographic extent of CAD was also analyzed using a method (CLASS) proposed by Gensini et al based on the CA territory, location and severity of stenosis, and collateral circulation. T1-201 JS correlated significantly with CLASS (r=.78, p<.01). Of the 45 pts with mild JS, only 5 (11%) had severe CLASS score. Thus, the size of the hypoperfused myocardium by quantitative stress- and redistribution T1-201 correlates better with a more complex angiographic estimate of myocardium at risk than conventional 1, 2, and 3 vessel disease classification

  15. Tamarisk (Tamarix spp.) water fluxes before, during and after episodic defoliation by the saltcedar leaf beetle

    Science.gov (United States)

    Hultine, K.R.; Nagler, P.L.; Dennison, P.E.; Bush, S.E.; Ehleringer, J.R.

    2009-01-01

    Tamarisk (Tamarix) species are among the most successful and economically costly plant invaders in the western United States, in part due to its potential to remove large amounts of water from shallow aquifers. Accordingly, local, state and federal agencies have released a new biological control - the saltcedar leaf beetle (Diorhabda elongata) along many watersheds in the western United States to reduce the spread of tamarisk. The beetle defoliates tamarisk for much of the growing season resulting in potentially large seasonal declines in productivity, fitness, and water loss from tamarisk stands. We measured sap flux density (Js) using heat dissipation sensors to investigate water use patterns of tamarisk before, during and after a single, six week beetle-induced defoliation event in southeastern, Utah, USA. Granier-style probes were installed on 20 dominant trees from May through September 2008, a period that covers almost the entire growing season. As the beetle emerged from dormancy in mid-June, daytime and nighttime Js measurably increased for approximately two weeks before declining to less than 20% of predicted values (predicted by modeling Js with atmospheric vapor pressure deficit in May and June before defoliation). Tamarisk trees in mid-August produced new leaves and Js returned to pre-defoliation levels. Total Js, summed over the duration of the study was 13% lower than predicted values. These data suggest that defoliation results in only small changes in seasonal water loss from tamarisk stands. Current research is focusing on long-term ecohydrological impacts of tamarisk defoliation over multiple growing seasons.

  16. Effects of tree-to-tree variations on sap flux-based transpiration estimates in a forested watershed

    Science.gov (United States)

    Kume, Tomonori; Tsuruta, Kenji; Komatsu, Hikaru; Kumagai, Tomo'omi; Higashi, Naoko; Shinohara, Yoshinori; Otsuki, Kyoichi

    2010-05-01

    To estimate forest stand-scale water use, we assessed how sample sizes affect confidence of stand-scale transpiration (E) estimates calculated from sap flux (Fd) and sapwood area (AS_tree) measurements of individual trees. In a Japanese cypress plantation, we measured Fd and AS_tree in all trees (n = 58) within a 20 × 20 m study plot, which was divided into four 10 × 10 subplots. We calculated E from stand AS_tree (AS_stand) and mean stand Fd (JS) values. Using Monte Carlo analyses, we examined potential errors associated with sample sizes in E, AS_stand, and JS by using the original AS_tree and Fd data sets. Consequently, we defined optimal sample sizes of 10 and 15 for AS_stand and JS estimates, respectively, in the 20 × 20 m plot. Sample sizes greater than the optimal sample sizes did not decrease potential errors. The optimal sample sizes for JS changed according to plot size (e.g., 10 × 10 m and 10 × 20 m), while the optimal sample sizes for AS_stand did not. As well, the optimal sample sizes for JS did not change in different vapor pressure deficit conditions. In terms of E estimates, these results suggest that the tree-to-tree variations in Fd vary among different plots, and that plot size to capture tree-to-tree variations in Fd is an important factor. This study also discusses planning balanced sampling designs to extrapolate stand-scale estimates to catchment-scale estimates.

  17. Sencha charts essentials

    CERN Document Server

    Kumar, Ajit

    2015-01-01

    If you are an Ext JS or Sencha Touch developer, designer, or architect who wants to build enterprise-scale data visualization capabilities using Sencha, then this book is ideal for you. You should have a knowledge of HTML, JavaScript, CSS, and Sencha Ext JS or Sencha Touch fundamentals, in particular. Some familiarity with SVG and HTML5 Canvas would be preferred, but not required.

  18. 77 FR 66194 - Notice of Applications for Deregistration Under Section 8(f) of the Investment Company Act of 1940

    Science.gov (United States)

    2012-11-02

    ... orders a hearing. Interested persons may request a hearing on any application by writing to the SEC's... certificate of service. Hearing requests should state the nature of the writer's interest, the reason for the... shareholders, based on net asset value. Expenses of $6,500 incurred in connection with the liquidation were...

  19. Ship motion effects in CTD-data from weakly stratified waters of the Puerto Rico trench

    NARCIS (Netherlands)

    van Haren, H.

    2015-01-01

    Shipborne SBE 911plus Conductivity Temperature Depth (CTD)-casts have been made to maximum 7220 m in the Puerto Rico Trench (PRT). In PRT-waters from 5500 m and deeper and specifically below the 6500 m transition to the hadal-zone, the vertical density stratification is found very weak, with

  20. 32 CFR 732.20 - Adjudication authorities.

    Science.gov (United States)

    2010-07-01

    ... Medical Affairs, Bethesda, MD 20814, Tele: (A/V) 295-5322 or (C) (301) 295-5322. (3) Mid-Atlantic Region... Medical Command, Mid-Atlantic Region, 6500 Hampton Boulevard, Norfolk, VA 23502, Attn: Office of Medical..., Roosevelt Roads, PR), for dental care rendered in Puerto Rico, the Virgin Islands, and other Caribbean...

  1. 26 CFR 1.306-2 - Exception.

    Science.gov (United States)

    2010-04-01

    ... is the avoidance of Federal income tax. [T.D. 6500, 25 FR 11607, Nov. 26, 1960, as amended by T.D... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Effects on Recipients § 1.306-2 Exception. (a) If a shareholder terminates his entire stock...

  2. 77 FR 29358 - Kenai National Wildlife Refuge, Soldotna, AK; Environmental Impact Statement for the Shadura...

    Science.gov (United States)

    2012-05-17

    ...: Meetings: We will locally announce any future meeting dates, times, and locations, at least 10 days prior... Mountains, with their glaciers, rise to more than 6,500 feet. Treeless alpine and subalpine habitats are... staging area and nesting habitat for shorebirds and waterfowl throughout the spring, summer, and fall. The...

  3. The Usumacinta-Grijalva beach-ridge plain in southern Mexico : A high-resolution archive of river discharge and precipitation

    NARCIS (Netherlands)

    Nooren, C.A.M.; Hoek, W.Z.; Winkels, T.G.; Huizinga, A.; van der Plicht, J.; Van Dam, R.; Van Heteren, S.; van Bergen, M.J.; Prins, M.A.; Reimann, T.; Wallinga, J.; Cohen, K.M.; Minderhoud, P.S.J.; Middelkoop, H.

    2017-01-01

    The beach-ridge sequence of the Usumacinta-Grijalva delta borders a 300 km long section of the southern Gulf of Mexico coast. With around 500 beach ridges formed in the last 6500 years, the sequence is unsurpassed in the world in terms of numbers of individual ridges preserved, continuity of the

  4. Cultivation and complete genome sequencing of Gloeobacter kilaueensis sp. nov., from a lava cave in Kīlauea Caldera, Hawai'i.

    Directory of Open Access Journals (Sweden)

    Jimmy H W Saw

    Full Text Available The ancestor of Gloeobacter violaceus PCC 7421(T is believed to have diverged from that of all known cyanobacteria before the evolution of thylakoid membranes and plant plastids. The long and largely independent evolutionary history of G. violaceus presents an organism retaining ancestral features of early oxygenic photoautotrophs, and in whom cyanobacteria evolution can be investigated. No other Gloeobacter species has been described since the genus was established in 1974 (Rippka et al., Arch Microbiol 100:435. Gloeobacter affiliated ribosomal gene sequences have been reported in environmental DNA libraries, but only the type strain's genome has been sequenced. However, we report here the cultivation of a new Gloeobacter species, G. kilaueensis JS1(T, from an epilithic biofilm in a lava cave in Kīlauea Caldera, Hawai'i. The strain's genome was sequenced from an enriched culture resembling a low-complexity metagenomic sample, using 9 kb paired-end 454 pyrosequences and 400 bp paired-end Illumina reads. The JS1(T and G. violaceus PCC 7421(T genomes have little gene synteny despite sharing 2842 orthologous genes; comparing the genomes shows they do not belong to the same species. Our results support establishing a new species to accommodate JS1(T, for which we propose the name Gloeobacter kilaueensis sp. nov. Strain JS1(T has been deposited in the American Type Culture Collection (BAA-2537, the Scottish Marine Institute's Culture Collection of Algae and Protozoa (CCAP 1431/1, and the Belgian Coordinated Collections of Microorganisms (ULC0316. The G. kilaueensis holotype has been deposited in the Algal Collection of the US National Herbarium (US# 217948. The JS1(T genome sequence has been deposited in GenBank under accession number CP003587. The G+C content of the genome is 60.54 mol%. The complete genome sequence of G. kilaueensis JS1(T may further understanding of cyanobacteria evolution, and the shift from anoxygenic to oxygenic photosynthesis.

  5. Seed rain after a fire in a xerophytic shrubland Lluvia de semillas después de un incendio en un matorral xerófilo

    Directory of Open Access Journals (Sweden)

    Yuriana Martínez-Orea

    2012-06-01

    Full Text Available Fire causes a reduction of plant cover due to the death of several structures, especially of those that are not isolated from high temperatures; such as seeds and fruits. After a disturbance the availability of diaspores is crucial for the recovery of the community. This work studied the composition and abundance of the seed rain in the xerophytic shrubland of the Pedregal de San Ángel Ecological Reserve, located at the Universidad Nacional Autónoma de México campus in Mexico City, which was affected by a surface fire. In order to understand the role of diaspores in the natural regeneration of a burned site, seed traps were placed on 2 sites, one affected by the fire and the other in an unburned location. During 1 year the dispersed seeds and fruits were collected and identified. Results showed that species richness, life forms, and dispersal syndromes were different between sites. The highest abundance and richness values were observed in the burned site. This work offers basic data on the availability of species as diaspores, information which is useful for potential restoration strategies especially in those areas under constant anthropogenic disturbances.El fuego causa la reducción de la cobertura vegetal debido a la muerte de diversas estructuras, especialmente de aquellas que no están aisladas de las altas temperaturas, tal es el caso de semillas y frutos. Dado que estas diásporas permiten la recuperación de la vegetación, resulta crucial entender su composición y abundancia sobre todo después de un disturbio. Este trabajo estudió la composición y abundancia de la lluvia de semillas en el matorral xerófilo Reserva ecológica del Pedregal de San Ángel, localizado en el campus de la Universidad Nacional Autónoma de México en la ciudad de México, el cual fue afectado por un incendio superficial. Con el fin de entender el papel de las diásporas en la regeneración natural se colocaron trampas de semillas en dos sitios, uno

  6. Monitoring and groundwater/gas sampling in sands densified with explosives

    Directory of Open Access Journals (Sweden)

    Carlos A. Vega-Posada

    2014-01-01

    Full Text Available Este manuscrito presenta los resultados de un estudio de densificación de suelos en campo utilizando explosivos y realizado en un relleno sanitario localizado en Carolina de Sur, Estados Unidos; este estudio se realizó con el objeto de determinar los tipos de gases que se liberan y sus respectivas concentraciones in situ después del proceso de densificación. Se utilizó un sistema de sonda BAT para recolectar las muestras de aguas subterráneas y de gas en la mitad del estrato en estudio, así como para medir la evolución de las presiones del agua durante y después de la detonación de las cargas explosivas. Adicionalmente, se hicieron mediciones topográficas a través del eje central longitudinal de la zona de estudio después de cada explosión para medir la magnitud y la efectividad de esta técnica de densificación en depósitos de arena sueltas. Los resultados de este estudio mostraron que: a el sistema de sonda BAT puede ser una técnica confiable para recolectar muestra de agua subterránea y gas en campo antes y después de la explosión; b la masa de suelo afectada por la detonación de los explosivos licuó por un periodo de 6 horas, mientras el esfuerzo vertical efectivo alcanzó sus valores iniciales después de 3 días; y c se observaron deformaciones verticales significativas en el área de estudio después de cada explosión, lo cual indica que la masa de suelo fue exitosamente densificada.

  7. Brote de rabia urbana transmitida por perros en el distrito de Santa Marta, Colombia, 2006-2008

    Directory of Open Access Journals (Sweden)

    Andrés Páez

    2009-09-01

    El control del brote se logró 20 meses después del primer caso en perros y 14 meses después de haberse iniciado la primera vacunación masiva en animales. Es necesario implementar y mantener acciones para el control de la rabia urbana y evitar su impacto en los humanos.

  8. La comprensión de la salud: punto de partida del enfoque sanológico en la promoción de la salud de la mujer adulta joven

    OpenAIRE

    MYRIAM PATRICIA PARDO TORRES; NICOLÁS ARTURO NÚÑEZ GÓMEZ

    2007-01-01

    Através de un estudio de intervención con diseño antes-después, se trabajó con un grupo de 100 mujeres en-tre 20 y 40 años residentes en la Localidad Cuarta del Distrito Capital de Bogotá (San Cristóbal), con el objetivo de identificar la comprensión de la salud antes de una intervención en promoción de la salud con enfoque sanológico, y la transformación que se genera después de la intervención. Para explorar el concepto de salud y las acciones para mantener la salud antes-después se utilizó...

  9. Fatiga del sistema nervioso después de una prueba de contrarreloj de 30’ en cicloergómetro en ciclistas jóvenes Fatigue of nervous system after a test trial of 30 'on a cycleergometer in young cyclists

    Directory of Open Access Journals (Sweden)

    V. J. Clemente

    2010-12-01

    Full Text Available

    Varios autores han estudiado la influencia del ejercicio sobre el sistema nervioso y el funcionamiento cognitivo en sujetos desentrenados y ante diferentes estímulos de ejercicio mediante los Umbrales Flicker Fusion (UFF. Aunque el efecto en el sistema nervioso central (SNC de estímulos máximos aeróbicos no está muy estudiado. El presente trabajo de investigación pretende estudiar los cambios en los UFF antes y después de realizar una contrareloj de 30’ en cicloergómetro, como medio para valorar la fatiga del SNC.
    La muestra la componen 9 sujetos varones (72.1±5.59 Kg., 180.3±6.43 cm, 17.4±0.7 años, 14.1±2.69 % grasa, 22.2±1.65 Kg./m2 de IMC, VO2max [ml/ Kg./min.] 83.24±4.06, VO2max [l]: 5.95±0.53.
    Se realizó una prueba de 30’ máximo en cicloergómetro. Previo al test y al finalizar éste, se realizaron las mediciones de los UFF ascendente, descendente y clásico, criterio subjetivo y sensibilidad sensorial. Cada sujeto realizó el test  de UFF en tres ocasiones obteniéndose un valor promedio.
    Los resultados muestran cómo los UFF aumentan después de la prueba. Con estos resultados podemos concluir que una prueba máxima de 30’ en cicloergómetro no parece que generen fatiga en el Sistema Nervioso Central medida con el sistema Flicker Fusion, al no disminuir los distintos UFF.
    Palabras clave:Sistema nervioso central, Fatiga, Umbrales Flicker Fusion, cicloergómetro

    Several authors have studied the influence of exercise on the nervous system and cognitive performance in untrained subjects and to different stimuli of exercise using the Flicker Fusion Threshold (UFF. Although the effect on the central nervous system (CNS of maximum aerobic stimuli is not well studied. This research aims to study changes in UFF before and after a time trial of 30 'on a cycloergometer, to evaluated the fatigue of the CNS.
    The sample consisted of nine male subjects (72.1±5.59 kg, 180.3±6.43 cm

  10. Comportamento subagudo da pressão arterial após o treinamento de força em hipertensos controlados Comportamiento sub-agudo de la presión arterial después del entrenamiento de fuerza en hipertensos controlados Subacute behavior of the blood pressure after power training in controlled hypertensive individuals

    Directory of Open Access Journals (Sweden)

    Mauro Felippe Felix Mediano

    2005-12-01

    Full Text Available Diversos estudos têm demonstrado um efeito benéfico do exercício de força sobre a redução da pressão arterial (PA pós-exercício, mas ainda são escassas as pesquisas envolvendo pessoas hipertensas. Dessa forma, o presente estudo tem como objetivo comparar as respostas de PA em sujeitos hipertensos medicados após duas sessões de exercício de força com diferentes volumes de treinamento. Para tal, foram estudados 20 indivíduos de ambos os gêneros (61 ± 12 anos com hipertensão controlada por fármacos e participantes de um programa de exercícios, porém sem experiência no treinamento de força. O estudo foi realizado em três dias não consecutivos. Primeiramente, foi determinada a carga de 10 repetições máximas em cada exercício da seqüência (supino reto, leg-press horizontal, remada em pé e rosca tríceps. Nos demais dias, os mesmos exercícios foram realizados com uma (SER1 ou três (SER3 séries. A aferição da PA foi executada pelo método auscultatório no momento pré-exercício, imediatamente após o término de cada sessão e durante 60 minutos após o término dos exercícios. A ANOVA de medidas repetidas identificou que em ambas as sessões os valores da PA sistólica (PAS e diastólica (PAD, medidos imediatamente após o término dos exercícios, foram mais elevados (p Varios estudios han estado demostrando un efecto beneficioso del ejercicio de fuerza en la reducción de la presión arterial (PA el pos ejercicio, pero todavía son escasos las investigaciones que han estudiado a las personas hipertensas. De esa manera, el estudio presente tiene como objetivo las comparaciones de las respuestas de PA en sujetos hipertensos en tratamiento medicamentoso, después de dos sesiones de ejercicio de fuerza con volúmenes de entrenamiento diferentes. Para ello, 20 individuos de ambos sexos se estudiaron (61 ± 12 años con hipertensión controlada por los fármacos y participantes de un programa de ejercicios, pero

  11. Incidencia de eventos vasculares mayores después de cirugía no cardiaca: impacto del monitoreo perioperatorio con troponina y electrocardiograma Incidence of major vascular events after cardiac surgery: impact of preoperative monitoring with troponin and electrocardiogram

    Directory of Open Access Journals (Sweden)

    Sandra M Quiroga

    2009-06-01

    Full Text Available Introducción: los cambios demográficos recientes condujeron a un aumento del riesgo de eventos vasculares mayores después de cirugía no cardiaca. El monitoreo con troponina y electrocardiografía identificaría más de estos eventos. Métodos: de manera prospectiva se recolectaron datos de pacientes elegibles (mayores de 45 años no seleccionados sometidos a cirugía no cardiaca, bajo anestesia regional o general, con estancia hospitalaria prevista mayor o igual a 24 horas en dos hospitales de Bucaramanga, durante dos períodos de tiempo, antes y después de monitoreo diagnóstico post-operatorio (evaluaciones seriadas de troponina T y electrocardiogramas sin conocimiento de datos clínicos. Para el componente de tiempo anterior a la intervención (cuidado clínico convencional, se tomaron historias clínicas de todos los pacientes elegibles de una muestra aleatoria de tres meses correspondientes a 2005. Para el componente de tiempo posterior al monitoreo, se siguieron 100 pacientes elegibles consecutivos. El desenlace primario fue la incidencia de eventos vasculares mayores intrahospitalarios, incluyendo infarto del miocardio (definido como troponina elevada asociada a cambios electrocardiográficos sugestivos, independiente de los síntomas. Resultados: se incluyeron 534 historias clínicas y 100 pacientes quirúrgicos prospectivos (edad media 62,2 años, DE 12,9; 56% mujeres. El tipo de cirugía más frecuente fue la ortopédica (26,8% seguida de la intra-abdominal (20,2%. La incidencia de eventos fue 2,8% en historias clínicas, en comparación con una incidencia de 7% en pacientes sometidos a monitoreo (p = 0,071. Los cuatro infartos del miocardio identificados en estos pacientes fueron silentes. Conclusión: el monitoreo diagnóstico post-operatorio con troponina y electrocardiografía, identificó una mayor proporción de eventos vasculares, principalmente infartos silentes del miocardio.Introduction: recent demographic changes have

  12. Book Review: 'Digital media sport: Technology, power and culture in the network society'

    OpenAIRE

    Sturm, DC

    2014-01-01

    Book Review for Gender and genre in sports documentaries: critical essays, edited by Zachary Ingle and David M. Sutera, Plymouth, Scarecrow Press, 2013, 204 pp., US$65.00/£39.95 (hardback), ISBN 978-0-8108-8788-6, US$64.99/£39.95 (eBook), ISBN 978-0-8108-5 8787-9

  13. Making Americans: UNO Charter Schools and Civic Education. Policy Brief 6

    Science.gov (United States)

    Feith, David

    2013-01-01

    This policy brief is the third in a series of in-depth case studies exploring how top-performing charter schools have incorporated civic learning in their school curriculum and school culture. The UNO Charter School Network includes 13 schools serving some 6,500 students across Chicago. Located in predominantly Hispanic neighborhoods, the…

  14. Effects of lithology on geothermal gradient on the southeast Nigeria ...

    African Journals Online (AJOL)

    A study of the effects of lithologic formations on geothermal gradients is carried out in the south-east Niger Delta, Nigeria, using continuous temperature and lithologic log data from closely-spaced petroleum wells. The gradient profiles obtained for the deep wells, logged to depths between 6500 ft (1981m) and 8500ft ...

  15. Counterterrorism

    Science.gov (United States)

    2009-11-13

    well as the resistance to conquest or occupation by a foreign power. (b) Ethnocentric . Groups of this persuasion view race as the defining...7 prepares publication for signature JSDS prepares JS staffing package JSDS staffs the publication via JSAP for signature LA selects...Primary Review Authority (PRA) to develop the first draft (FD) PRA/USJFCOM develops FD for staffing with JDDC FD comment matrix adjudication JS J-7

  16. Técnica de doble pedículo lateral en reconstrucción mamaria después de tumorectomía Double lateral pedicle technique in breast reconstruction after tumorectomy

    Directory of Open Access Journals (Sweden)

    Orlando Rafael Expósito Reyes

    2007-12-01

    Full Text Available Los tumores mamarios aparecen cada vez con mayor frecuencia, e igualmente las secuelas poco estéticas de la cirugía de estos. Se presenta la técnica quirúrgica de doble pedículo externo (superior e inferior en la reconstrucción mamaria después de una tumorectomía por fibroadenoma gigante de la mama izquierda. Se planificó la intervención tomando como referencia la técnica de Skoog (pedículo lateral externo, por la localización, el área ocupada por la masa mamaria (3/4 partes de la mama y para conservar la irrigación del complejo areola-pezón. Para llenar el vacío dejado por el tumor, se utilizó un segundo pedículo inferolateral que se liberó, rotó y fijó a la fascia muscular, con sutura no absorbible, en el área del cuadrante superior interno, lo cual sirvió de relleno o apoyo al complejo areola-pezón y a su pedículo. Se obtuvo un resultado estético bueno, que satisfizo las expectativas de la paciente y de los médicos, al conservarse la mama y su forma.Breast tumors are more and more frequent, as well as the little aesthetic sequelae of their surgery. The external double pedicle surgical technique (upper and lower in breast reconstruction after a tumorectomy due to giant fibroadenoma of the left breast was presented. The operation was planned taking Skoog’s technique as a reference (external lateral pedicle by the localization, the area occupied by the breast mass (3/4 parts of the breast and to preserve the irrigation of the areola-nipple complex. To fill the gap left by the tumor, it was used a second inferolateral pedicle that was released, rotated and fixed to the muscle fascia with non-absorbable suture in the area of the upper internal quadrant that served as a filling or support to the areola-nipple complex and to its pedicle. A good aesthetic result that satisfied the patients and specialists’ expectations was obtained on conserving the breast and its form.

  17. Qualidade de vida relacionada à saúde, antes e seis meses após a revascularização do miocárdio Calidad de vida relacionada con la salud antes y seis meses después de la revascularización miocárdica Health-related quality of life before and six months after coronary artery bypass graft surgery

    Directory of Open Access Journals (Sweden)

    Cristiane Franca Lisboa Gois

    2009-12-01

    Full Text Available A cirurgia de revascularização do miocárdio (CRM visa melhorar a qualidade de vida relacionada à saúde (QVRS, aliviar sintomas e aumentar a sobrevida. Objetivou-se comparar a QVRS antes e seis meses após CRM e avaliar a sua relação com idade, sexo, escolaridade e estado civil. Estudo descritivo e longitudinal que utilizou o SF-36 para avaliar a QVRS. Entre os 54 sujeitos, 53,7% eram homens, 66,7% casados, com idade média de 57,3+9,7 anos e 5,7+4 anos de escolaridade. Após a CRM as médias dos domínios do SF-36 variaram de 62 a 74,2 sendo o intervalo anterior de 17,1 a 58,1. Homens apresentaram melhor avaliação da QVRS antes e após a CRM do que as mulheres, mas as diferenças foram estatisticamente significantes apenas para Estado geral de saúde e Dor. Não se constatou associação entre QVRS, escolaridade e estado civil. Concluiu-se que a CRM melhorou a QVRS dos participantes.La cirugía de revascularización del miocardio (CRVM busca ofrecer una mejor calidad de vida relacionada con la salud (CVRS, aliviar los síntomas de angina y aumentar la sobrevida. Los objetivos foi comparar la CVRS antes y seis meses después de la CRVM y evaluar su relación con la edad, sexo, escolaridad y estado civil. Estudio descriptivo y longitudinal, que utilizó el SF-36 para evaluar la CVRS. Entre los 54 participantes, 53,7% eran hombres, 66,7% casados, con edad media de 57,3+9,7 años y 5,7+4 años de escolaridad. Después de la CRVM las medias de los dominios del SF-36 variaron de 62 a 74,2 siendo el intervalo anterior de 17,1 a 58,1. Hombres presentaron mejor evaluación de CVRS antes e después de la CRVM que las mujeres, entretanto las diferencias fueron estadísticamente significativas sólo para Estado General de salud y Dolor. No se encontró asociación entre CVRS, escolaridad y estado civil. Las conclusión es que la CRVM mejoró la CVRS de los participantes.Coronary artery bypass grafting (CABG surgery aims at offering a better health

  18. Perú, después de las elecciones

    Directory of Open Access Journals (Sweden)

    Luis PÁSARA

    2009-11-01

    Full Text Available RESUMEN: En este artículo se reflexiona sobre la elección presidencial peruana a partir de los resultados electorales de la primera y la segunda vuelta electoral. El autor sostiene que la elección de Alejandro Toledo no supone una recuperación del país y expone las características de los comicios en los que participó la mitad de la población. Asimismo, analiza el perfil del nuevo elector peruano «el cholo» y lo señala como el nuevo protagonista social del Perú; reflexiona respecto a la salida de Fujimori y Montesinos del poder y puntualiza el papel de Estados Unidos en la caída del régimen fujimorista.ABSTRACT: This article analyzes the Peruvian presidential election taking as a point of departure the electoral results of the first and second rounds. The author argues that the election of Alejandro Toledo does not imply a recovery of the country and he presents the characteristics of the electoral contest in which half of the population participated. He also analyzes the profile of the new Peruvian voter, the «cholo», and points to them as new social protagonists in Peru. The author reflects on the exit from power of Fujimori and Montesinos, specifying the role of the United States in the fall of the Fujimori regime.

  19. Peak power, force, and velocity during jump squats in professional rugby players.

    Science.gov (United States)

    Turner, Anthony P; Unholz, Cedric N; Potts, Neill; Coleman, Simon G S

    2012-06-01

    Training at the optimal load for peak power output (PPO) has been proposed as a method for enhancing power output, although others argue that the force, velocity, and PPO are of interest across the full range of loads. The aim of this study was to examine the influence of load on PPO, peak barbell velocity (BV), and peak vertical ground reaction force (VGRF) during the jump squat (JS) in a group of professional rugby players. Eleven male professional rugby players (age, 26 ± 3 years; height, 1.83 ± 6.12 m; mass, 97.3 ± 11.6 kg) performed loaded JS at loads of 20-100% of 1 repetition maximum (1RM) JS. A force plate and linear position transducer, with a mechanical braking unit, were used to measure PPO, VGRF, and BV. Load had very large significant effects on PPO (p < 0.001, partial η² = 0.915); peak VGRF (p < 0.001, partial η² = 0.854); and peak BV (p < 0.001, partial η² = 0.973). The PPO and peak BV were the highest at 20% 1RM, though PPO was not significantly greater than that at 30% 1RM. The peak VGRF was significantly greater at 1RM than all other loads, with no significant difference between 20 and 60% 1RM. In resistance trained professional rugby players, the optimal load for eliciting PPO during the loaded JS in the range measured occurs at 20% 1RM JS, with decreases in PPO and BV, and increases in VGRF, as the load is increased, although greater PPO likely occurs without any additional load.

  20. Cysteine-Rich Peptide Family with Unusual Disulfide Connectivity from Jasminum sambac.

    Science.gov (United States)

    Kumari, Geeta; Serra, Aida; Shin, Joon; Nguyen, Phuong Q T; Sze, Siu Kwan; Yoon, Ho Sup; Tam, James P

    2015-11-25

    Cysteine-rich peptides (CRPs) are natural products with privileged peptidyl structures that represent a potentially rich source of bioactive compounds. Here, the discovery and characterization of a novel plant CRP family, jasmintides from Jasminum sambac of the Oleaceae family, are described. Two 27-amino acid jasmintides (jS1 and jS2) were identified at the gene and protein levels. Disulfide bond mapping of jS1 by mass spectrometry and its confirmation by NMR spectroscopy revealed disulfide bond connectivity of C-1-C-5, C-2-C-4, and C-3-C-6, a cystine motif that has not been reported in plant CRPs. Structural determination showed that jS1 displays a well-defined structure framed by three short antiparallel β-sheets. Genomic analysis showed that jasmintides share a three-domain precursor arrangement with a C-terminal mature domain preceded by a long pro-domain of 46 residues and an intron cleavage site between the signal sequence and pro-domain. The compact cysteine-rich structure together with an N-terminal pyroglutamic acid residue confers jasmintides high resistance to heat and enzymatic degradation, including exopeptidase treatment. Collectively, these results reveal a new plant CRP structure with an unusual cystine connectivity, which could be useful as a scaffold for designing peptide drugs.